complex_id corr_pval t_count q_count qandt_count qandt_by_q qandt_by_t term_id t_type t_group t_name depth_in_group qandt_list 0 1.60e-08 24 3 3 1.000 0.125 GO:0071230 BP 1 cellular response to amino acid stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 1.82e-08 25 3 3 1.000 0.120 GO:0032008 BP 1 positive regulation of TOR signaling 1 Q9HB90,Q7L523,Q8NBW4 0 2.31e-08 27 3 3 1.000 0.111 GO:0043200 BP 1 response to amino acid 1 Q9HB90,Q7L523,Q8NBW4 0 2.57e-07 59 3 3 1.000 0.051 GO:0032006 BP 1 regulation of TOR signaling 1 Q9HB90,Q7L523,Q8NBW4 0 3.78e-07 67 3 3 1.000 0.045 GO:0031929 BP 1 TOR signaling 1 Q9HB90,Q7L523,Q8NBW4 0 5.12e-07 74 3 3 1.000 0.041 GO:0071229 BP 1 cellular response to acid chemical 1 Q9HB90,Q7L523,Q8NBW4 0 5.46e-07 4 3 2 0.667 0.500 GO:1990131 CC 1 Gtr1-Gtr2 GTPase complex 1 Q9HB90,Q7L523 0 9.10e-07 5 3 2 0.667 0.400 GO:0034448 CC 1 EGO complex 1 Q9HB90,Q7L523 0 1.02e-06 93 3 3 1.000 0.032 GO:0001101 BP 1 response to acid chemical 1 Q9HB90,Q7L523,Q8NBW4 0 7.10e-06 13 3 2 0.667 0.154 GO:1903432 BP 1 regulation of TORC1 signaling 1 Q9HB90,Q7L523 0 8.28e-06 14 3 2 0.667 0.143 GO:0038202 BP 1 TORC1 signaling 1 Q9HB90,Q7L523 0 1.39e-05 18 3 2 0.667 0.111 GO:0034198 BP 1 cellular response to amino acid starvation 1 Q9HB90,Q7L523 0 1.52e-05 227 3 3 1.000 0.013 GO:0044440 CC 1 endosomal part 1 Q9HB90,Q7L523,Q8NBW4 0 2.29e-05 260 3 3 1.000 0.012 GO:0071417 BP 1 cellular response to organonitrogen compound 1 Q9HB90,Q7L523,Q8NBW4 0 3.77e-05 307 3 3 1.000 0.010 GO:0010243 BP 1 response to organonitrogen compound 1 Q9HB90,Q7L523,Q8NBW4 0 4.07e-05 315 3 3 1.000 0.010 GO:1901699 BP 1 cellular response to nitrogen compound 1 Q9HB90,Q7L523,Q8NBW4 0 5.22e-05 342 3 3 1.000 0.009 GO:0000323 CC 1 lytic vacuole 1 Q9HB90,Q7L523,Q8NBW4 0 5.22e-05 342 3 3 1.000 0.009 GO:0005764 CC 1 lysosome 1 Q9HB90,Q7L523,Q8NBW4 0 6.21e-05 22 3 2 0.667 0.091 REAC:166208 rea 1 mTORC1-mediated signalling 1 Q9HB90,Q7L523 0 7.05e-05 378 3 3 1.000 0.008 GO:1901698 BP 1 response to nitrogen compound 1 Q9HB90,Q7L523,Q8NBW4 0 7.99e-05 394 3 3 1.000 0.008 GO:0005773 CC 1 vacuole 1 Q9HB90,Q7L523,Q8NBW4 0 9.44e-05 27 3 2 0.667 0.074 REAC:380972 rea 1 Energy dependent regulation of mTOR by LKB1-AMPK 1 Q9HB90,Q7L523 0 1.14e-04 444 3 3 1.000 0.007 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 Q9HB90,Q7L523,Q8NBW4 0 1.14e-04 444 3 3 1.000 0.007 GO:0098796 CC 1 membrane protein complex 1 Q9HB90,Q7L523,Q8NBW4 0 1.32e-04 466 3 3 1.000 0.006 GO:0005768 CC 1 endosome 1 Q9HB90,Q7L523,Q8NBW4 0 1.47e-04 483 3 3 1.000 0.006 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 1.63e-04 499 3 3 1.000 0.006 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q9HB90,Q7L523,Q8NBW4 0 1.89e-04 38 3 2 0.667 0.053 REAC:165159 rea 1 mTOR signalling 1 Q9HB90,Q7L523 0 1.95e-04 66 3 2 0.667 0.030 GO:0009267 BP 1 cellular response to starvation 1 Q9HB90,Q7L523 0 1.99e-04 39 3 2 0.667 0.051 REAC:109703 rea 1 PKB-mediated events 1 Q9HB90,Q7L523 0 2.32e-04 72 3 2 0.667 0.028 GO:0042594 BP 1 response to starvation 1 Q9HB90,Q7L523 0 2.63e-04 586 3 3 1.000 0.005 GO:1901700 BP 1 response to oxygen-containing compound 1 Q9HB90,Q7L523,Q8NBW4 0 3.08e-04 83 3 2 0.667 0.024 GO:0031669 BP 1 cellular response to nutrient levels 1 Q9HB90,Q7L523 0 3.48e-04 643 3 3 1.000 0.005 GO:0071495 BP 1 cellular response to endogenous stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 3.71e-04 91 3 2 0.667 0.022 GO:0031668 BP 1 cellular response to extracellular stimulus 1 Q9HB90,Q7L523 0 4.66e-04 102 3 2 0.667 0.020 GO:0005525 MF 1 GTP binding 1 Q9HB90,Q7L523 0 4.73e-04 712 3 3 1.000 0.004 GO:0009719 BP 1 response to endogenous stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 5.23e-04 108 3 2 0.667 0.019 GO:0031667 BP 1 response to nutrient levels 1 Q9HB90,Q7L523 0 5.25e-04 1 3 1 0.333 1.000 GO:0045919 BP 1 positive regulation of cytolysis 1 Q7L523 0 5.57e-04 65 3 2 0.667 0.031 REAC:109704 rea 1 PI3K Cascade 1 Q9HB90,Q7L523 0 5.73e-04 759 3 3 1.000 0.004 GO:0098805 CC 1 whole membrane 1 Q9HB90,Q7L523,Q8NBW4 0 5.75e-04 66 3 2 0.667 0.030 REAC:1632852 rea 1 Macroautophagy 1 Q9HB90,Q7L523 0 5.82e-04 763 3 3 1.000 0.004 GO:0009967 BP 1 positive regulation of signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 6.35e-04 119 3 2 0.667 0.017 GO:0009991 BP 1 response to extracellular stimulus 1 Q9HB90,Q7L523 0 6.35e-04 119 3 2 0.667 0.017 GO:0071496 BP 1 cellular response to external stimulus 1 Q9HB90,Q7L523 0 6.66e-04 798 3 3 1.000 0.004 GO:0010647 BP 1 positive regulation of cell communication 1 Q9HB90,Q7L523,Q8NBW4 0 6.78e-04 123 3 2 0.667 0.016 GO:0032561 MF 1 guanyl ribonucleotide binding 1 Q9HB90,Q7L523 0 6.81e-04 804 3 3 1.000 0.004 GO:0023056 BP 1 positive regulation of signaling 1 Q9HB90,Q7L523,Q8NBW4 0 6.90e-04 124 3 2 0.667 0.016 GO:0019001 MF 1 guanyl nucleotide binding 1 Q9HB90,Q7L523 0 8.25e-04 79 3 2 0.667 0.025 REAC:5628897 rea 1 TP53 Regulates Metabolic Genes 1 Q9HB90,Q7L523 0 9.88e-04 910 3 3 1.000 0.003 GO:0097708 CC 1 intracellular vesicle 1 Q9HB90,Q7L523,Q8NBW4 0 1.05e-03 2 3 1 0.333 0.500 GO:0042268 BP 1 regulation of cytolysis 1 Q7L523 0 1.06e-03 931 3 3 1.000 0.003 GO:0031410 CC 1 cytoplasmic vesicle 1 Q9HB90,Q7L523,Q8NBW4 0 1.11e-03 945 3 3 1.000 0.003 GO:0098588 CC 1 bounding membrane of organelle 1 Q9HB90,Q7L523,Q8NBW4 0 1.11e-03 1318 3 3 1.000 0.002 TF:M00693_0 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 1.12e-03 158 3 2 0.667 0.013 GO:0003924 MF 1 GTPase activity 1 Q9HB90,Q7L523 0 1.42e-03 1027 3 3 1.000 0.003 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 1.44e-03 179 3 2 0.667 0.011 GO:0046982 MF 1 protein heterodimerization activity 1 Q9HB90,Q7L523 0 1.45e-03 180 3 2 0.667 0.011 GO:0007050 BP 1 cell cycle arrest 1 Q9HB90,Q7L523 0 1.68e-03 1086 3 3 1.000 0.003 GO:0048584 BP 1 positive regulation of response to stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 1.85e-03 203 3 2 0.667 0.010 GO:0016236 BP 1 macroautophagy 1 Q9HB90,Q7L523 0 1.92e-03 207 3 2 0.667 0.010 GO:0010506 BP 1 regulation of autophagy 1 Q9HB90,Q7L523 0 2.03e-03 1157 3 3 1.000 0.003 GO:0071310 BP 1 cellular response to organic substance 1 Q9HB90,Q7L523,Q8NBW4 0 2.09e-03 216 3 2 0.667 0.009 GO:0005774 CC 1 vacuolar membrane 1 Q9HB90,Q7L523 0 2.10e-03 4 3 1 0.333 0.250 GO:1990130 CC 1 Iml1 complex 1 Q7L523 0 2.10e-03 4 3 1 0.333 0.250 GO:1904263 BP 1 positive regulation of TORC1 signaling 1 Q7L523 0 2.62e-03 5 3 1 0.333 0.200 GO:0019835 BP 1 cytolysis 1 Q7L523 0 3.15e-03 6 3 1 0.333 0.167 GO:0071986 CC 1 Ragulator complex 1 Q8NBW4 0 3.47e-03 279 3 2 0.667 0.007 GO:0044437 CC 1 vacuolar part 1 Q9HB90,Q7L523 0 3.56e-03 1394 3 3 1.000 0.002 GO:0010033 BP 1 response to organic substance 1 Q9HB90,Q7L523,Q8NBW4 0 3.71e-03 1414 3 3 1.000 0.002 GO:0031090 CC 1 organelle membrane 1 Q9HB90,Q7L523,Q8NBW4 0 3.78e-03 1423 3 3 1.000 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 4.24e-03 18 3 1 0.333 0.056 TF:M05948_0 tf 1 Factor: ZNF582; motif: NTGGAAGAACGC; match class: 0 1 Q9HB90 0 4.73e-03 1533 3 3 1.000 0.002 GO:0035556 BP 1 intracellular signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 4.76e-03 327 3 2 0.667 0.006 GO:0035639 MF 1 purine ribonucleoside triphosphate binding 1 Q9HB90,Q7L523 0 5.11e-03 1573 3 3 1.000 0.002 GO:0009966 BP 1 regulation of signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 5.15e-03 340 3 2 0.667 0.006 GO:0006914 BP 1 autophagy 1 Q9HB90,Q7L523 0 5.42e-03 349 3 2 0.667 0.006 GO:0032549 MF 1 ribonucleoside binding 1 Q9HB90,Q7L523 0 5.42e-03 349 3 2 0.667 0.006 GO:0032550 MF 1 purine ribonucleoside binding 1 Q9HB90,Q7L523 0 5.45e-03 350 3 2 0.667 0.006 GO:0001883 MF 1 purine nucleoside binding 1 Q9HB90,Q7L523 0 5.54e-03 353 3 2 0.667 0.006 GO:0001882 MF 1 nucleoside binding 1 Q9HB90,Q7L523 0 5.95e-03 366 3 2 0.667 0.005 GO:0032555 MF 1 purine ribonucleotide binding 1 Q9HB90,Q7L523 0 6.13e-03 585 3 2 0.667 0.003 TF:M00621_1 tf 1 Factor: C/EBPdelta; motif: MATTKCNTMAYY; match class: 1 1 Q7L523,Q8NBW4 0 6.15e-03 372 3 2 0.667 0.005 GO:0032553 MF 1 ribonucleotide binding 1 Q9HB90,Q7L523 0 6.28e-03 376 3 2 0.667 0.005 GO:0045786 BP 1 negative regulation of cell cycle 1 Q9HB90,Q7L523 0 6.30e-03 12 3 1 0.333 0.083 GO:0003333 BP 1 amino acid transmembrane transport 1 Q8NBW4 0 6.35e-03 378 3 2 0.667 0.005 GO:0017076 MF 1 purine nucleotide binding 1 Q9HB90,Q7L523 0 6.35e-03 1691 3 3 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 Q9HB90,Q7L523,Q8NBW4 0 6.41e-03 2365 3 3 1.000 0.001 TF:M07424_0 tf 1 Factor: MEF-2; motif: NNYTATTTTTAGN; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 6.78e-03 1728 3 3 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 Q9HB90,Q7L523,Q8NBW4 0 7.34e-03 14 3 1 0.333 0.071 GO:0035859 CC 1 Seh1-associated complex 1 Q7L523 0 7.56e-03 240 3 2 0.667 0.008 REAC:112399 rea 1 IRS-mediated signalling 1 Q9HB90,Q7L523 0 7.62e-03 241 3 2 0.667 0.008 REAC:2428924 rea 1 IGF1R signaling cascade 1 Q9HB90,Q7L523 0 7.62e-03 241 3 2 0.667 0.008 REAC:2428928 rea 1 IRS-related events triggered by IGF1R 1 Q9HB90,Q7L523 0 7.69e-03 242 3 2 0.667 0.008 REAC:74751 rea 1 Insulin receptor signalling cascade 1 Q9HB90,Q7L523 0 7.69e-03 242 3 2 0.667 0.008 REAC:2404192 rea 1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1 Q9HB90,Q7L523 0 7.71e-03 2515 3 3 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 Q9HB90,Q7L523,Q8NBW4 0 7.76e-03 33 3 1 0.333 0.030 TF:M05798_0 tf 1 Factor: ZNF517; motif: NGGGAAGGCGGC; match class: 0 1 Q8NBW4 0 8.76e-03 1882 3 3 1.000 0.002 GO:0042221 BP 1 response to chemical 1 Q9HB90,Q7L523,Q8NBW4 0 9.06e-03 263 3 2 0.667 0.008 REAC:74752 rea 1 Signaling by Insulin receptor 1 Q9HB90,Q7L523 0 9.09e-03 2657 3 3 1.000 0.001 TF:M00132_0 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 1.01e-02 479 3 2 0.667 0.004 GO:0000166 MF 1 nucleotide binding 1 Q9HB90,Q7L523 0 1.02e-02 480 3 2 0.667 0.004 GO:1901265 MF 1 nucleoside phosphate binding 1 Q9HB90,Q7L523 0 1.08e-02 46 3 1 0.333 0.022 TF:M00972_1 tf 1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 1 Q9HB90 0 1.21e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 Q9HB90,Q7L523,Q8NBW4 0 1.22e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 Q9HB90,Q7L523,Q8NBW4 0 1.28e-02 540 3 2 0.667 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 Q9HB90,Q7L523 0 1.35e-02 553 3 2 0.667 0.004 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 Q9HB90,Q7L523 0 1.38e-02 560 3 2 0.667 0.004 GO:0046983 MF 1 protein dimerization activity 1 Q9HB90,Q7L523 0 1.43e-02 331 3 2 0.667 0.006 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q9HB90,Q7L523 0 1.45e-02 62 3 1 0.333 0.016 TF:M02113_0 tf 1 Factor: OCA-B; motif: ATATGCAAATC; match class: 0 1 Q7L523 0 1.52e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 Q9HB90,Q7L523,Q8NBW4 0 1.53e-02 590 3 2 0.667 0.003 GO:0016462 MF 1 pyrophosphatase activity 1 Q9HB90,Q7L523 0 1.54e-02 592 3 2 0.667 0.003 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 Q9HB90,Q7L523 0 1.54e-02 592 3 2 0.667 0.003 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Q9HB90,Q7L523 0 1.55e-02 3176 3 3 1.000 0.001 TF:M01020_0 tf 1 Factor: Tbx5; motif: TNAGGTGTKV; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 1.57e-02 30 3 1 0.333 0.033 GO:0019048 BP 1 modulation by virus of host morphology or physiology 1 Q7L523 0 1.64e-02 612 3 2 0.667 0.003 GO:0036094 MF 1 small molecule binding 1 Q9HB90,Q7L523 0 1.66e-02 71 3 1 0.333 0.014 TF:M05497_0 tf 1 Factor: TBX20; motif: AGGTGTKAAAN; match class: 0 1 Q9HB90 0 1.68e-02 32 3 1 0.333 0.031 GO:1903825 BP 1 organic acid transmembrane transport 1 Q8NBW4 0 1.68e-02 32 3 1 0.333 0.031 GO:0051219 MF 1 phosphoprotein binding 1 Q7L523 0 1.68e-02 32 3 1 0.333 0.031 GO:1905039 BP 1 carboxylic acid transmembrane transport 1 Q8NBW4 0 1.83e-02 35 3 1 0.333 0.029 GO:0031902 CC 1 late endosome membrane 1 Q8NBW4 0 1.84e-02 1025 3 2 0.667 0.002 TF:M07123_0 tf 1 Factor: rfx5; motif: YNSCMTRGCAACAGN; match class: 0 1 Q7L523,Q8NBW4 0 1.84e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 Q9HB90,Q7L523,Q8NBW4 0 1.85e-02 378 3 2 0.667 0.005 REAC:2262752 rea 1 Cellular responses to stress 1 Q9HB90,Q7L523 0 1.88e-02 36 3 1 0.333 0.028 GO:0044003 BP 1 modification by symbiont of host morphology or physiology 1 Q7L523 0 1.99e-02 85 3 1 0.333 0.012 TF:M00634_1 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 1 1 Q9HB90 0 2.01e-02 86 3 1 0.333 0.012 TF:M07434_1 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 1 1 Q8NBW4 0 2.01e-02 86 3 1 0.333 0.012 TF:M04133_0 tf 1 Factor: TBX2; motif: GGTGTGANAWNTSACACC; match class: 0 1 Q8NBW4 0 2.01e-02 679 3 2 0.667 0.003 GO:0051726 BP 1 regulation of cell cycle 1 Q9HB90,Q7L523 0 2.09e-02 40 3 1 0.333 0.025 GO:0010507 BP 1 negative regulation of autophagy 1 Q7L523 0 2.13e-02 91 3 1 0.333 0.011 TF:M05748_0 tf 1 Factor: ZNF697; motif: NTGGGCRTCGGC; match class: 0 1 Q9HB90 0 2.14e-02 1109 3 2 0.667 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 Q7L523,Q8NBW4 0 2.20e-02 94 3 1 0.333 0.011 TF:M06523_0 tf 1 Factor: ZNF527; motif: KGGAGWATGCGM; match class: 0 1 Q8NBW4 0 2.25e-02 43 3 1 0.333 0.023 GO:0015171 MF 1 amino acid transmembrane transporter activity 1 Q8NBW4 0 2.30e-02 44 3 1 0.333 0.023 GO:0019003 MF 1 GDP binding 1 Q9HB90 0 2.34e-02 100 3 1 0.333 0.010 TF:M06541_0 tf 1 Factor: ZNF502; motif: NGKTAGGRAATC; match class: 0 1 Q7L523 0 2.39e-02 102 3 1 0.333 0.010 TF:M07089_1 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 1 1 Q8NBW4 0 2.48e-02 106 3 1 0.333 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 Q8NBW4 0 2.50e-02 107 3 1 0.333 0.009 TF:M04163_0 tf 1 Factor: BHLHE41; motif: NKCACGTGMC; match class: 0 1 Q9HB90 0 2.55e-02 109 3 1 0.333 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q9HB90 0 2.59e-02 111 3 1 0.333 0.009 TF:M05462_0 tf 1 Factor: znf581; motif: NTGTGGGCAC; match class: 0 1 Q7L523 0 2.72e-02 3828 3 3 1.000 0.001 TF:M03889_0 tf 1 Factor: TBX2; motif: AGGTGTGARM; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 2.72e-02 3829 3 3 1.000 0.001 TF:M01709_1 tf 1 Factor: MAFA; motif: TCAGCAN; match class: 1 1 Q9HB90,Q7L523,Q8NBW4 0 2.77e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 Q9HB90,Q7L523,Q8NBW4 0 2.80e-02 120 3 1 0.333 0.008 TF:M05297_0 tf 1 Factor: Sox-1; motif: TRAATATTWAA; match class: 0 1 Q7L523 0 2.87e-02 2795 3 3 1.000 0.001 GO:0031982 CC 1 vesicle 1 Q9HB90,Q7L523,Q8NBW4 0 2.94e-02 126 3 1 0.333 0.008 TF:M07417_1 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 1 1 Q8NBW4 0 2.95e-02 826 3 2 0.667 0.002 GO:0043168 MF 1 anion binding 1 Q9HB90,Q7L523 0 3.02e-02 835 3 2 0.667 0.002 GO:0009605 BP 1 response to external stimulus 1 Q9HB90,Q7L523 0 3.04e-02 3971 3 3 1.000 0.001 TF:M03565_0 tf 1 Factor: slug; motif: KCACCTGN; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 3.14e-02 114 3 1 0.333 0.009 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q9HB90 0 3.17e-02 1357 3 2 0.667 0.001 TF:M07391_1 tf 1 Factor: NKX2B; motif: ANNCACTTNA; match class: 1 1 Q9HB90,Q7L523 0 3.19e-02 4038 3 3 1.000 0.001 TF:M00790_0 tf 1 Factor: HNF1; motif: WRGTTAATNATTAACNNN; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 3.24e-02 139 3 1 0.333 0.007 TF:M05366_0 tf 1 Factor: Tbr-1; motif: TTNACACCTR; match class: 0 1 Q9HB90 0 3.24e-02 139 3 1 0.333 0.007 TF:M05321_0 tf 1 Factor: TBR2; motif: TTNACACCTR; match class: 0 1 Q9HB90 0 3.24e-02 139 3 1 0.333 0.007 TF:M05495_0 tf 1 Factor: T-bet; motif: TTAACACCTA; match class: 0 1 Q9HB90 0 3.29e-02 63 3 1 0.333 0.016 GO:0051817 BP 1 modification of morphology or physiology of other organism involved in symbiotic interaction 1 Q7L523 0 3.34e-02 64 3 1 0.333 0.016 GO:0006865 BP 1 amino acid transport 1 Q8NBW4 0 3.36e-02 144 3 1 0.333 0.007 TF:M07362_1 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 1 1 Q8NBW4 0 3.44e-02 4142 3 3 1.000 0.001 TF:M01665_1 tf 1 Factor: IRF-8; motif: AGTTTCW; match class: 1 1 Q9HB90,Q7L523,Q8NBW4 0 3.45e-02 1418 3 2 0.667 0.001 TF:M07434_0 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 0 1 Q9HB90,Q8NBW4 0 3.45e-02 66 3 1 0.333 0.015 GO:0035821 BP 1 modification of morphology or physiology of other organism 1 Q7L523 0 3.56e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 Q9HB90,Q7L523,Q8NBW4 0 3.60e-02 131 3 1 0.333 0.008 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 Q9HB90 0 3.63e-02 4215 3 3 1.000 0.001 TF:M02271_0 tf 1 Factor: HOXA5; motif: CDBWAATK; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 3.66e-02 157 3 1 0.333 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q9HB90 0 3.67e-02 3033 3 3 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 Q9HB90,Q7L523,Q8NBW4 0 3.71e-02 71 3 1 0.333 0.014 GO:0098656 BP 1 anion transmembrane transport 1 Q8NBW4 0 3.75e-02 161 3 1 0.333 0.006 TF:M03892_1 tf 1 Factor: VDR:RXR-alpha; motif: RRGGTCAN; match class: 1 1 Q9HB90 0 3.76e-02 407 3 2 0.667 0.005 MI:hsa-miR-921 mi 1 MI:hsa-miR-921 1 Q7L523,Q8NBW4 0 3.85e-02 1274 3 2 0.667 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q9HB90,Q7L523 0 3.86e-02 74 3 1 0.333 0.014 GO:0046943 MF 1 carboxylic acid transmembrane transporter activity 1 Q8NBW4 0 3.90e-02 952 3 2 0.667 0.002 GO:0022402 BP 1 cell cycle process 1 Q9HB90,Q7L523 0 3.91e-02 75 3 1 0.333 0.013 GO:0005342 MF 1 organic acid transmembrane transporter activity 1 Q8NBW4 0 4.09e-02 176 3 1 0.333 0.006 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 Q7L523 0 4.09e-02 4387 3 3 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 Q9HB90,Q7L523,Q8NBW4 0 4.41e-02 190 3 1 0.333 0.005 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 Q7L523 0 4.43e-02 442 3 2 0.667 0.005 MI:hsa-miR-182 mi 1 MI:hsa-miR-182 1 Q7L523,Q8NBW4 0 4.45e-02 443 3 2 0.667 0.005 MI:hsa-miR-553 mi 1 MI:hsa-miR-553 1 Q7L523,Q8NBW4 0 4.46e-02 192 3 1 0.333 0.005 TF:M04012_1 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 1 1 Q7L523 0 4.53e-02 1029 3 2 0.667 0.002 GO:0008219 BP 1 cell death 1 Q9HB90,Q7L523 0 4.56e-02 3262 3 3 1.000 0.001 GO:0007154 BP 1 cell communication 1 Q9HB90,Q7L523,Q8NBW4 0 4.59e-02 3268 3 3 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 Q9HB90,Q7L523,Q8NBW4 0 4.61e-02 3274 3 3 1.000 0.001 GO:0023052 BP 1 signaling 1 Q9HB90,Q7L523,Q8NBW4 0 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q9HB90,Q7L523,Q8NBW4 0 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9HB90,Q7L523 0 4.96e-02 468 3 2 0.667 0.004 MI:hsa-miR-802 mi 1 MI:hsa-miR-802 1 Q7L523,Q8NBW4 0 5.00e-02 96 3 1 0.333 0.010 GO:0008514 MF 1 organic anion transmembrane transporter activity 1 Q8NBW4 0 5.00e-02 134 3 3 1.000 0.022 KEGG:04150 keg 1 mTOR signaling pathway 1 Q9HB90,Q7L523,Q8NBW4 0 5.00e-02 470 3 2 0.667 0.004 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 Q7L523,Q8NBW4 1 1.80e-03 13 1 1 1.000 0.077 REAC:140342 rea 1 Apoptosis induced DNA fragmentation 1 Q02539 1 1.80e-03 13 1 1 1.000 0.077 REAC:211227 rea 1 Activation of DNA fragmentation factor 1 Q02539 1 2.21e-03 16 1 1 1.000 0.062 REAC:2559584 rea 1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1 Q02539 1 6.64e-03 48 1 1 1.000 0.021 REAC:2559586 rea 1 DNA Damage/Telomere Stress Induced Senescence 1 Q02539 1 7.06e-03 51 1 1 1.000 0.020 REAC:75153 rea 1 Apoptotic execution phase 1 Q02539 1 1.37e-02 148 1 1 1.000 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q02539 1 1.49e-02 161 1 1 1.000 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q02539 1 1.82e-02 8 1 1 1.000 0.125 CORUM:5609 cor 1 Emerin regulatory complex 1 Q02539 1 1.86e-02 201 1 1 1.000 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q02539 1 1.90e-02 205 1 1 1.000 0.005 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 Q02539 1 1.91e-02 138 1 1 1.000 0.007 REAC:2559583 rea 1 Cellular Senescence 1 Q02539 1 2.01e-02 217 1 1 1.000 0.005 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 Q02539 1 2.20e-02 159 1 1 1.000 0.006 REAC:109581 rea 1 Apoptosis 1 Q02539 1 2.24e-02 162 1 1 1.000 0.006 REAC:5357801 rea 1 Programmed Cell Death 1 Q02539 1 2.84e-02 307 1 1 1.000 0.003 HPA:004010_03 hpa 1 breast; adipocytes[Uncertain,High] 1 Q02539 1 2.95e-02 13 1 1 1.000 0.077 CORUM:5611 cor 1 Emerin complex 24 1 Q02539 1 3.05e-02 329 1 1 1.000 0.003 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 Q02539 1 3.17e-02 332 1 1 1.000 0.003 MI:hsa-miR-545* mi 1 MI:hsa-miR-545* 1 Q02539 1 3.23e-02 349 1 1 1.000 0.003 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 Q02539 1 3.25e-02 351 1 1 1.000 0.003 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 Q02539 1 3.33e-02 360 1 1 1.000 0.003 HPA:021010_03 hpa 1 liver; bile duct cells[Uncertain,High] 1 Q02539 1 3.36e-02 363 1 1 1.000 0.003 HPA:026020_03 hpa 1 ovary; ovarian stroma cells[Uncertain,High] 1 Q02539 1 3.42e-02 358 1 1 1.000 0.003 MI:hsa-miR-148a* mi 1 MI:hsa-miR-148a* 1 Q02539 1 3.47e-02 375 1 1 1.000 0.003 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 Q02539 1 3.57e-02 10 1 1 1.000 0.100 TF:M05857_0 tf 1 Factor: ZNF710; motif: CNCSAGAATTAAWA; match class: 0 1 Q02539 1 3.62e-02 391 1 1 1.000 0.003 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 Q02539 1 3.65e-02 394 1 1 1.000 0.003 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 Q02539 1 3.70e-02 399 1 1 1.000 0.003 HPA:002020_13 hpa 1 appendix; lymphoid tissue[Supportive,High] 1 Q02539 1 3.74e-02 404 1 1 1.000 0.002 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q02539 1 3.75e-02 393 1 1 1.000 0.003 MI:rno-miR-352 mi 1 MI:rno-miR-352 1 Q02539 1 3.78e-02 408 1 1 1.000 0.002 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q02539 1 3.87e-02 406 1 1 1.000 0.002 MI:mmu-miR-468 mi 1 MI:mmu-miR-468 1 Q02539 1 4.11e-02 431 1 1 1.000 0.002 MI:hsa-miR-433 mi 1 MI:hsa-miR-433 1 Q02539 1 4.14e-02 434 1 1 1.000 0.002 MI:hsa-miR-139-3p mi 1 MI:hsa-miR-139-3p 1 Q02539 1 4.21e-02 454 1 1 1.000 0.002 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q02539 1 4.32e-02 453 1 1 1.000 0.002 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 Q02539 1 4.41e-02 476 1 1 1.000 0.002 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 Q02539 1 4.43e-02 464 1 1 1.000 0.002 MI:hsa-miR-876-5p mi 1 MI:hsa-miR-876-5p 1 Q02539 1 4.48e-02 484 1 1 1.000 0.002 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q02539 1 4.50e-02 486 1 1 1.000 0.002 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q02539 1 4.53e-02 489 1 1 1.000 0.002 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q02539 1 4.55e-02 477 1 1 1.000 0.002 MI:hsa-miR-498 mi 1 MI:hsa-miR-498 1 Q02539 1 4.57e-02 479 1 1 1.000 0.002 MI:hsa-miR-516a-5p mi 1 MI:hsa-miR-516a-5p 1 Q02539 1 4.60e-02 482 1 1 1.000 0.002 MI:mmu-miR-464 mi 1 MI:mmu-miR-464 1 Q02539 1 4.68e-02 505 1 1 1.000 0.002 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q02539 1 4.78e-02 501 1 1 1.000 0.002 MI:mmu-miR-465a-3p mi 1 MI:mmu-miR-465a-3p 1 Q02539 1 4.83e-02 506 1 1 1.000 0.002 MI:mmu-miR-467b mi 1 MI:mmu-miR-467b 1 Q02539 1 4.83e-02 506 1 1 1.000 0.002 MI:hsa-miR-524-3p mi 1 MI:hsa-miR-524-3p 1 Q02539 1 4.97e-02 537 1 1 1.000 0.002 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q02539 1 5.00e-02 22 1 1 1.000 0.045 CORUM:5615 cor 1 Emerin complex 52 1 Q02539 1 5.00e-02 14 1 1 1.000 0.071 TF:M04024_0 tf 1 Factor: MEF-2D; motif: NCTAWAAATAGM; match class: 0 1 Q02539 1 5.00e-02 524 1 1 1.000 0.002 MI:mmu-miR-467d mi 1 MI:mmu-miR-467d 1 Q02539 1 5.00e-02 14 1 1 1.000 0.071 GO:0005719 CC 1 nuclear euchromatin 1 Q02539 2 7.01e-14 93 7 7 1.000 0.075 REAC:3214847 rea 1 HATs acetylate histones 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 1.06e-13 14 7 5 0.714 0.357 GO:0005671 CC 1 Ada2/Gcn5/Ada3 transcription activator complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.47e-11 211 7 7 1.000 0.033 REAC:4839726 rea 1 Chromatin organization 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 2.47e-11 211 7 7 1.000 0.033 REAC:3247509 rea 1 Chromatin modifying enzymes 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 2.64e-11 38 7 5 0.714 0.132 GO:1902562 CC 1 H4 histone acetyltransferase complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.23e-10 51 7 5 0.714 0.098 GO:0043966 BP 1 histone H3 acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.34e-09 81 7 5 0.714 0.062 GO:0000123 CC 1 histone acetyltransferase complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.42e-09 91 7 5 0.714 0.055 GO:1902493 CC 1 acetyltransferase complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.42e-09 91 7 5 0.714 0.055 GO:0031248 CC 1 protein acetyltransferase complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 4.56e-09 103 7 5 0.714 0.049 GO:0016573 BP 1 histone acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 5.02e-09 105 7 5 0.714 0.048 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 5.53e-09 107 7 5 0.714 0.047 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 6.36e-09 110 7 5 0.714 0.045 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.32e-08 127 7 5 0.714 0.039 GO:0006473 BP 1 protein acetylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.86e-08 148 7 5 0.714 0.034 GO:0043543 BP 1 protein acylation 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 4.63e-08 50 7 4 0.571 0.080 GO:0004402 MF 1 histone acetyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 5.02e-08 51 7 4 0.571 0.078 GO:0061733 MF 1 peptide-lysine-N-acetyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 8.51e-08 58 7 4 0.571 0.069 GO:0034212 MF 1 peptide N-acetyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 1.94e-07 71 7 4 0.571 0.056 GO:0008080 MF 1 N-acetyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 3.16e-07 80 7 4 0.571 0.050 GO:0016410 MF 1 N-acyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 3.49e-07 82 7 4 0.571 0.049 GO:0016407 MF 1 acetyltransferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 7.14e-07 281 7 5 0.714 0.018 GO:0016570 BP 1 histone modification 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 8.36e-07 290 7 5 0.714 0.017 GO:0016569 BP 1 covalent chromatin modification 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 9.26e-07 296 7 5 0.714 0.017 GO:0018205 BP 1 peptidyl-lysine modification 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.36e-06 30 7 3 0.429 0.100 GO:0070461 CC 1 SAGA-type complex 1 Q92830,Q92831,O75528 2 2.64e-06 10 7 3 0.429 0.300 CORUM:471 cor 1 PCAF complex 1 Q92831,O75528,O75478 2 2.64e-06 10 7 3 0.429 0.300 CORUM:477 cor 1 PCAF complex 1 Q92831,O75528,O75478 2 4.79e-06 157 7 4 0.571 0.025 GO:0016747 MF 1 transferase activity, transferring acyl groups other than amino-acyl groups 1 Q92830,Q92831,Q9H8E8,O75528 2 7.36e-06 449 7 5 0.714 0.011 GO:0006325 BP 1 chromatin organization 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 7.56e-06 176 7 4 0.571 0.023 GO:0016746 MF 1 transferase activity, transferring acyl groups 1 Q92830,Q92831,Q9H8E8,O75528 2 1.54e-05 521 7 5 0.714 0.010 GO:0044451 CC 1 nucleoplasm part 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 3.74e-05 624 7 5 0.714 0.008 GO:1990234 CC 1 transferase complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 5.43e-05 10 7 2 0.286 0.200 REAC:350054 rea 1 Notch-HLH transcription pathway 1 Q92830,Q92831 2 7.40e-05 11 7 2 0.286 0.182 GO:0030914 CC 1 STAGA complex 1 Q92830,O75528 2 7.55e-05 720 7 5 0.714 0.007 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.22e-04 14 7 2 0.286 0.143 GO:0033276 CC 1 transcription factor TFTC complex 1 Q92830,O75528 2 3.90e-04 26 7 2 0.286 0.077 REAC:1912408 rea 1 Pre-NOTCH Transcription and Translation 1 Q92830,Q92831 2 4.39e-04 1033 7 5 0.714 0.005 GO:1902494 CC 1 catalytic complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 4.54e-04 10 7 2 0.286 0.200 CORUM:438 cor 1 GCN5-TRRAP histone acetyltransferase complex 1 Q92830,O75528 2 6.63e-04 12 7 2 0.286 0.167 CORUM:475 cor 1 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q92830,O75528 2 7.33e-04 362 7 3 0.429 0.008 TF:M03847_1 tf 1 Factor: Sox15; motif: ACAAWGGG; match class: 1 1 Q8IYH5,Q9H8E8,O75528 2 7.83e-04 13 7 2 0.286 0.154 CORUM:476 cor 1 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q92830,O75528 2 9.29e-04 40 7 2 0.286 0.050 REAC:2122947 rea 1 NOTCH1 Intracellular Domain Regulates Transcription 1 Q92830,Q92831 2 1.02e-03 42 7 2 0.286 0.048 REAC:1912422 rea 1 Pre-NOTCH Expression and Processing 1 Q92830,Q92831 2 1.18e-03 45 7 2 0.286 0.044 REAC:5250924 rea 1 B-WICH complex positively regulates rRNA expression 1 Q92830,Q92831 2 1.20e-03 16 7 2 0.286 0.125 CORUM:456 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.20e-03 16 7 2 0.286 0.125 CORUM:462 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.20e-03 16 7 2 0.286 0.125 CORUM:455 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.20e-03 16 7 2 0.286 0.125 CORUM:445 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.20e-03 16 7 2 0.286 0.125 CORUM:459 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.22e-03 238 7 3 0.429 0.013 GO:0003713 MF 1 transcription coactivator activity 1 Q92830,Q92831,O75528 2 1.28e-03 47 7 2 0.286 0.043 REAC:2644606 rea 1 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1 Q92830,Q92831 2 1.28e-03 47 7 2 0.286 0.043 REAC:73762 rea 1 RNA Polymerase I Transcription Initiation 1 Q92830,Q92831 2 1.28e-03 47 7 2 0.286 0.043 REAC:2644602 rea 1 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1 Q92830,Q92831 2 1.28e-03 47 7 2 0.286 0.043 REAC:2894858 rea 1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1 Q92830,Q92831 2 1.28e-03 47 7 2 0.286 0.043 REAC:2644603 rea 1 Signaling by NOTCH1 in Cancer 1 Q92830,Q92831 2 1.28e-03 47 7 2 0.286 0.043 REAC:2894862 rea 1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1 Q92830,Q92831 2 1.36e-03 17 7 2 0.286 0.118 CORUM:513 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.36e-03 17 7 2 0.286 0.118 CORUM:470 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q92830,O75528 2 1.37e-03 348 7 4 0.571 0.011 MI:hsa-miR-518f* mi 1 MI:hsa-miR-518f* 1 Q8IYH5,Q92830,Q9H8E8,O75528 2 1.38e-03 105 7 2 0.286 0.019 TF:M07415_0 tf 1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 0 1 Q9ULM3,O75528 2 1.38e-03 46 7 2 0.286 0.043 GO:0045815 BP 1 positive regulation of gene expression, epigenetic 1 Q92830,Q92831 2 1.76e-03 39 7 2 0.286 0.051 KEGG:04330 keg 1 Notch signaling pathway 1 Q92830,Q92831 2 2.02e-03 59 7 2 0.286 0.034 REAC:1980143 rea 1 Signaling by NOTCH1 1 Q92830,Q92831 2 2.09e-03 60 7 2 0.286 0.033 REAC:5250913 rea 1 Positive epigenetic regulation of rRNA expression 1 Q92830,Q92831 2 2.30e-03 63 7 2 0.286 0.032 REAC:73854 rea 1 RNA Polymerase I Promoter Clearance 1 Q92830,Q92831 2 2.45e-03 65 7 2 0.286 0.031 REAC:73864 rea 1 RNA Polymerase I Transcription 1 Q92830,Q92831 2 2.59e-03 63 7 2 0.286 0.032 GO:0042826 MF 1 histone deacetylase binding 1 Q92830,Q92831 2 2.67e-03 5462 7 7 1.000 0.001 TF:M00240_1 tf 1 Factor: Nkx2-5; motif: TYAAGTG; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 3.33e-03 335 7 3 0.429 0.009 GO:0008134 MF 1 transcription factor binding 1 Q92830,Q92831,Q9ULM3 2 3.74e-03 1614 7 5 0.714 0.003 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 5.15e-03 89 7 2 0.286 0.022 GO:0090575 CC 1 RNA polymerase II transcription factor complex 1 Q92830,O75528 2 5.18e-03 95 7 2 0.286 0.021 REAC:157118 rea 1 Signaling by NOTCH 1 Q92830,Q92831 2 5.42e-03 396 7 3 0.429 0.008 GO:0003712 MF 1 transcription cofactor activity 1 Q92830,Q92831,O75528 2 5.47e-03 6050 7 7 1.000 0.001 TF:M02057_1 tf 1 Factor: Elf5; motif: CSMGGAARNN; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 5.49e-03 10 7 1 0.143 0.100 TF:M06562_0 tf 1 Factor: ZNF431; motif: NGTTAAGGCAGA; match class: 0 1 Q92830 2 5.50e-03 92 7 2 0.286 0.022 GO:0016591 CC 1 DNA-directed RNA polymerase II, holoenzyme 1 Q92830,O75528 2 5.51e-03 98 7 2 0.286 0.020 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 Q92830,Q92831 2 5.67e-03 2657 7 5 0.714 0.002 TF:M00132_0 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 0 1 Q8IYH5,Q9H8E8,Q9ULM3,O75528,O75478 2 5.85e-03 101 7 2 0.286 0.020 REAC:212165 rea 1 Epigenetic regulation of gene expression 1 Q92830,Q92831 2 6.04e-03 970 7 4 0.571 0.004 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q92830,Q92831,Q9ULM3,O75528 2 6.28e-03 2931 7 6 0.857 0.002 GO:0031981 CC 1 nuclear lumen 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 6.47e-03 421 7 3 0.429 0.007 GO:0000989 MF 1 transcription factor activity, transcription factor binding 1 Q92830,Q92831,O75528 2 6.62e-03 101 7 2 0.286 0.020 GO:0044798 CC 1 nuclear transcription factor complex 1 Q92830,O75528 2 6.74e-03 427 7 3 0.429 0.007 GO:0000988 MF 1 transcription factor activity, protein binding 1 Q92830,Q92831,O75528 2 7.62e-03 251 7 2 0.286 0.008 TF:M03899_1 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 1 1 Q8IYH5,Q92831 2 7.68e-03 14 7 1 0.143 0.071 TF:M04150_1 tf 1 Factor: TFAP2B; motif: NGCCTSAGGCN; match class: 1 1 O75478 2 7.75e-03 542 7 4 0.571 0.007 MI:hsa-miR-518d-5p mi 1 MI:hsa-miR-518d-5p 1 Q8IYH5,Q92830,Q9H8E8,O75528 2 7.78e-03 3 7 1 0.143 0.333 GO:0004468 MF 1 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor 1 Q92831 2 7.78e-03 3 7 1 0.143 0.333 GO:0010484 MF 1 H3 histone acetyltransferase activity 1 Q92830 2 7.78e-03 3 7 1 0.143 0.333 GO:0018076 BP 1 N-terminal peptidyl-lysine acetylation 1 Q92831 2 7.80e-03 2 7 1 0.143 0.500 CORUM:1338 cor 1 FOXO3-PCAF complex, oxidative stress stimulated 1 Q92831 2 7.92e-03 256 7 2 0.286 0.008 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q9ULM3,O75528 2 8.41e-03 114 7 2 0.286 0.018 GO:0000428 CC 1 DNA-directed RNA polymerase complex 1 Q92830,O75528 2 8.41e-03 114 7 2 0.286 0.018 GO:0055029 CC 1 nuclear DNA-directed RNA polymerase complex 1 Q92830,O75528 2 8.53e-03 266 7 2 0.286 0.008 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 O75528,O75478 2 8.56e-03 115 7 2 0.286 0.017 GO:0006338 BP 1 chromatin remodeling 1 Q92830,Q92831 2 8.71e-03 116 7 2 0.286 0.017 GO:0030880 CC 1 RNA polymerase complex 1 Q92830,O75528 2 9.31e-03 17 7 1 0.143 0.059 TF:M06785_0 tf 1 Factor: ZNF629; motif: NGWTAMGAAACC; match class: 0 1 Q92830 2 9.79e-03 3168 7 6 0.857 0.002 GO:0044428 CC 1 nuclear part 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.04e-02 4 7 1 0.143 0.250 GO:0000125 CC 1 PCAF complex 1 Q92831 2 1.04e-02 4 7 1 0.143 0.250 GO:0010835 BP 1 regulation of protein ADP-ribosylation 1 Q92831 2 1.09e-02 6678 7 7 1.000 0.001 TF:M02265_1 tf 1 Factor: NFATC2; motif: TTTTCCA; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 1.16e-02 4666 7 6 0.857 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9ULM3,O75528,O75478 2 1.16e-02 8 7 1 0.143 0.125 REAC:5578768 rea 1 Physiological factors 1 Q92831 2 1.17e-02 3 7 1 0.143 0.333 CORUM:478 cor 1 STAGA core complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q92830 2 1.17e-02 3 7 1 0.143 0.333 CORUM:2641 cor 1 p300/CBP-PCAF-MyoD complex 1 Q92831 2 1.17e-02 3 7 1 0.143 0.333 CORUM:5373 cor 1 Chromatin remodeling complex (TACC2, TACC3, PCAF) 1 Q92831 2 1.22e-02 321 7 2 0.286 0.006 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 Q92830,Q9ULM3 2 1.24e-02 105 7 2 0.286 0.019 KEGG:04919 keg 1 Thyroid hormone signaling pathway 1 Q92830,Q92831 2 1.25e-02 1177 7 4 0.571 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q92830,Q92831,Q9ULM3,O75528 2 1.28e-02 2096 7 5 0.714 0.002 GO:0043234 CC 1 protein complex 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.30e-02 5 7 1 0.143 0.200 GO:0030274 MF 1 LIM domain binding 1 Q9H8E8 2 1.42e-02 26 7 1 0.143 0.038 TF:M02268_1 tf 1 Factor: INSM1; motif: TGYCAGGGGGCR; match class: 1 1 Q92830 2 1.48e-02 354 7 2 0.286 0.006 TF:M01298_0 tf 1 Factor: MECP2; motif: CCGGSNNNANNAWWT; match class: 0 1 Q92830,O75478 2 1.53e-02 28 7 1 0.143 0.036 TF:M06008_1 tf 1 Factor: ZBTB40; motif: KTCSTATTY; match class: 1 1 Q8IYH5 2 1.55e-02 2047 7 4 0.571 0.002 TF:M01816_0 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 0 1 Q92830,Q92831,Q9ULM3,O75478 2 1.56e-02 4 7 1 0.143 0.250 CORUM:3062 cor 1 RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying 1 Q92831 2 1.56e-02 4 7 1 0.143 0.250 CORUM:4 cor 1 Multisubunit ACTR coactivator complex 1 Q92831 2 1.56e-02 364 7 2 0.286 0.005 TF:M03981_1 tf 1 Factor: ETV3; motif: ACCGGAAGTN; match class: 1 1 Q9ULM3,O75528 2 1.58e-02 29 7 1 0.143 0.034 TF:M06629_0 tf 1 Factor: ZNF578; motif: NGAACCWKCCGA; match class: 0 1 Q9H8E8 2 1.72e-02 384 7 2 0.286 0.005 TF:M02072_1 tf 1 Factor: Pet-1; motif: ACCGGAWRTN; match class: 1 1 Q9ULM3,O75528 2 1.74e-02 5021 7 6 0.857 0.001 TF:M07208_0 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 0 1 Q8IYH5,Q92830,Q92831,Q9ULM3,O75528,O75478 2 1.80e-02 168 7 2 0.286 0.012 GO:0005667 CC 1 transcription factor complex 1 Q92830,O75528 2 1.81e-02 3435 7 5 0.714 0.001 TF:M00483_0 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 0 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.84e-02 1125 7 3 0.429 0.003 TF:M04345_0 tf 1 Factor: HOXB13; motif: CCAATAAAAN; match class: 0 1 Q9H8E8,O75528,O75478 2 1.86e-02 2153 7 4 0.571 0.002 TF:M04341_0 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 0 1 Q92831,Q9H8E8,O75528,O75478 2 1.86e-02 34 7 1 0.143 0.029 TF:M05768_0 tf 1 Factor: ZNF544; motif: GTWAAAACGM; match class: 0 1 Q92831 2 1.87e-02 2275 7 5 0.714 0.002 GO:0036211 BP 1 protein modification process 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.87e-02 2275 7 5 0.714 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.87e-02 401 7 2 0.286 0.005 TF:M04322_0 tf 1 Factor: GBX1; motif: NCYAATTANN; match class: 0 1 Q92831,O75478 2 1.90e-02 3561 7 6 0.857 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.90e-02 3561 7 6 0.857 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.90e-02 3561 7 6 0.857 0.002 GO:0043233 CC 1 organelle lumen 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 1.91e-02 35 7 1 0.143 0.029 TF:M04418_0 tf 1 Factor: OTX1; motif: NNTAATCCGATTANN; match class: 0 1 Q9H8E8 2 2.09e-02 181 7 2 0.286 0.011 GO:0040029 BP 1 regulation of gene expression, epigenetic 1 Q92830,Q92831 2 2.13e-02 429 7 2 0.286 0.005 TF:M00797_0 tf 1 Factor: HIF1; motif: GNNKACGTGCGGNN; match class: 0 1 Q8IYH5,Q9ULM3 2 2.33e-02 6 7 1 0.143 0.167 CORUM:3061 cor 1 RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying 1 Q92831 2 2.33e-02 9 7 1 0.143 0.111 GO:0004861 MF 1 cyclin-dependent protein serine/threonine kinase inhibitor activity 1 Q92831 2 2.33e-02 9 7 1 0.143 0.111 GO:0060049 BP 1 regulation of protein glycosylation 1 Q92831 2 2.47e-02 2417 7 5 0.714 0.002 GO:0043412 BP 1 macromolecule modification 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 2.58e-02 1276 7 3 0.429 0.002 TF:M00136_0 tf 1 Factor: Oct-1; motif: NNGAATATKCANNNN; match class: 0 1 Q9H8E8,Q9ULM3,O75528 2 2.60e-02 5402 7 6 0.857 0.001 TF:M01104_1 tf 1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9ULM3,O75528,O75478 2 2.60e-02 2370 7 4 0.571 0.002 TF:M04624_0 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 0 1 Q8IYH5,Q9ULM3,O75528,O75478 2 2.61e-02 48 7 1 0.143 0.021 TF:M06103_0 tf 1 Factor: ZNF325; motif: NKGGCAAGAARM; match class: 0 1 Q92831 2 2.61e-02 48 7 1 0.143 0.021 TF:M04116_0 tf 1 Factor: EOMES; motif: TCACACCTNNNNAGGTGTGA; match class: 0 1 O75528 2 2.71e-02 7 7 1 0.143 0.143 CORUM:3137 cor 1 MASH1 promoter-coactivator complex 1 Q92831 2 2.83e-02 5486 7 6 0.857 0.001 TF:M02056_0 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 0 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 2.85e-02 501 7 2 0.286 0.004 TF:M01078_1 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 1 Q9ULM3,O75528 2 2.86e-02 162 7 2 0.286 0.012 KEGG:05203 keg 1 Viral carcinogenesis 1 Q92830,Q92831 2 2.88e-02 53 7 1 0.143 0.019 TF:M06549_0 tf 1 Factor: ZNF721; motif: NGARGTGGGGTG; match class: 0 1 O75528 2 2.94e-02 216 7 2 0.286 0.009 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q92830,O75528 2 2.99e-02 55 7 1 0.143 0.018 TF:M04420_0 tf 1 Factor: OTX2; motif: NNTAATCCGATTANN; match class: 0 1 Q9H8E8 2 2.99e-02 55 7 1 0.143 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q8IYH5 2 3.03e-02 2529 7 5 0.714 0.002 GO:0005654 CC 1 nucleoplasm 1 Q92830,Q92831,Q9H8E8,Q9ULM3,O75528 2 3.10e-02 8 7 1 0.143 0.125 CORUM:3142 cor 1 CAMK2-delta-MASH1 promoter-coactivator complex 1 Q92831 2 3.10e-02 12 7 1 0.143 0.083 GO:0016922 MF 1 ligand-dependent nuclear receptor binding 1 O75528 2 3.10e-02 12 7 1 0.143 0.083 GO:0000124 CC 1 SAGA complex 1 O75528 2 3.20e-02 59 7 1 0.143 0.017 TF:M03955_0 tf 1 Factor: ONECUT1; motif: NAAAAATCRATANN; match class: 0 1 Q92831 2 3.31e-02 61 7 1 0.143 0.016 TF:M00766_0 tf 1 Factor: LXR; motif: TGACCGNNAGTRACCC; match class: 0 1 O75528 2 3.36e-02 13 7 1 0.143 0.077 GO:0017025 MF 1 TBP-class protein binding 1 Q9ULM3 2 3.47e-02 64 7 1 0.143 0.016 TF:M05899_0 tf 1 Factor: ZNF454; motif: TTGAAAGCGTCTR; match class: 0 1 Q92831 2 3.47e-02 24 7 1 0.143 0.042 REAC:2032785 rea 1 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1 Q92831 2 3.49e-02 559 7 2 0.286 0.004 TF:M02063_1 tf 1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 1 Q9ULM3,O75528 2 3.60e-02 1446 7 3 0.429 0.002 TF:M07327_1 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 1 1 Q92830,Q92831,O75528 2 3.62e-02 14 7 1 0.143 0.071 GO:0006474 BP 1 N-terminal protein amino acid acetylation 1 Q92831 2 3.68e-02 68 7 1 0.143 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 Q9H8E8 2 3.71e-02 712 7 3 0.429 0.004 REAC:597592 rea 1 Post-translational protein modification 1 Q92830,Q92831,O75528 2 3.73e-02 1465 7 3 0.429 0.002 TF:M01284_1 tf 1 Factor: SOX9; motif: RNACAAAGGVN; match class: 1 1 Q8IYH5,Q9H8E8,O75528 2 3.73e-02 69 7 1 0.143 0.014 TF:M06709_0 tf 1 Factor: ZNF355P; motif: GWTAAAAMGC; match class: 0 1 Q92831 2 3.79e-02 70 7 1 0.143 0.014 TF:M06397_0 tf 1 Factor: ZNF761; motif: NGGTYGGGCAWA; match class: 0 1 O75478 2 3.82e-02 4078 7 5 0.714 0.001 TF:M07277_1 tf 1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 1 Q8IYH5,Q92830,Q92831,Q9ULM3,O75528 2 3.86e-02 10 7 1 0.143 0.100 CORUM:441 cor 1 TFTC-type histone acetyl transferase complex 1 Q92830 2 3.88e-02 592 7 2 0.286 0.003 TF:M01231_1 tf 1 Factor: ZNF515; motif: GTGGGGGGTM; match class: 1 1 Q92830,Q92831 2 3.90e-02 4097 7 5 0.714 0.001 TF:M03969_0 tf 1 Factor: ELF5; motif: ANSMGGAAGTN; match class: 0 1 Q92831,Q9H8E8,Q9ULM3,O75528,O75478 2 4.18e-02 1530 7 3 0.429 0.002 TF:M04363_0 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 0 1 Q9H8E8,O75528,O75478 2 4.18e-02 1530 7 3 0.429 0.002 TF:M04357_0 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 0 1 Q9H8E8,O75528,O75478 2 4.20e-02 618 7 2 0.286 0.003 TF:M01798_1 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 1 1 Q9H8E8,O75478 2 4.34e-02 629 7 2 0.286 0.003 TF:M03983_1 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 1 1 Q9ULM3,O75528 2 4.41e-02 1656 7 4 0.571 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q92830,Q92831,Q9ULM3,O75528 2 4.42e-02 635 7 2 0.286 0.003 TF:M04141_1 tf 1 Factor: TEAD1; motif: NRCATTCCWN; match class: 1 1 Q92831,Q9H8E8 2 4.42e-02 1563 7 3 0.429 0.002 TF:M04149_1 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 1 1 Q8IYH5,O75528,O75478 2 4.42e-02 82 7 1 0.143 0.012 TF:M06210_0 tf 1 Factor: ZNF33a; motif: NGGGHTTAMCGA; match class: 0 1 Q9ULM3 2 4.43e-02 5964 7 6 0.857 0.001 TF:M04027_0 tf 1 Factor: MEIS1; motif: NTGACAN; match class: 0 1 Q8IYH5,Q92830,Q92831,Q9H8E8,Q9ULM3,O75478 2 4.47e-02 1663 7 4 0.571 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q92830,Q92831,Q9ULM3,O75528 2 4.58e-02 85 7 1 0.143 0.012 TF:M06863_0 tf 1 Factor: ZNF789; motif: NGGTKAGGCGGW; match class: 0 1 Q92830 2 4.62e-02 651 7 2 0.286 0.003 TF:M03789_0 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 0 1 Q9H8E8,Q9ULM3 2 4.65e-02 1681 7 4 0.571 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q92830,Q92831,Q9ULM3,O75528 2 4.70e-02 1601 7 3 0.429 0.002 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 Q9H8E8,Q9ULM3,O75528 2 4.72e-02 1603 7 3 0.429 0.002 TF:M02055_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q9ULM3,O75528,O75478 2 4.72e-02 1603 7 3 0.429 0.002 TF:M01214_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q9ULM3,O75528,O75478 2 4.79e-02 89 7 1 0.143 0.011 TF:M04229_0 tf 1 Factor: FOXB1; motif: GAATGACACRGCGA; match class: 0 1 O75478 2 4.95e-02 92 7 1 0.143 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 Q9ULM3 2 5.00e-02 13 7 1 0.143 0.077 CORUM:3066 cor 1 RNA polymerase II complex, chromatin structure modifying 1 Q92831 2 5.00e-02 1715 7 4 0.571 0.002 GO:0016740 MF 1 transferase activity 1 Q92830,Q92831,Q9H8E8,O75528 2 5.00e-02 365 7 3 0.429 0.008 MI:hsa-miR-518e* mi 1 MI:hsa-miR-518e* 1 Q8IYH5,Q92830,O75528 2 5.00e-02 309 7 2 0.286 0.006 REAC:5663202 rea 1 Diseases of signal transduction 1 Q92830,Q92831 2 5.00e-02 218 7 2 0.286 0.009 KEGG:05166 keg 1 HTLV-I infection 1 Q92830,Q92831 3 1.98e-03 499 2 2 1.000 0.004 MI:hsa-miR-582-5p mi 1 MI:hsa-miR-582-5p 1 P31942,Q32P51 3 2.53e-02 147 2 1 0.500 0.007 GO:0005681 CC 1 spliceosomal complex 1 P31942 3 3.76e-02 219 2 1 0.500 0.005 GO:0030855 BP 1 epithelial cell differentiation 1 P31942 3 4.54e-02 265 2 1 0.500 0.004 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P31942 3 4.54e-02 265 2 1 0.500 0.004 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P31942 3 4.61e-02 269 2 1 0.500 0.004 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P31942 3 5.00e-02 128 2 1 0.500 0.008 KEGG:03040 keg 1 Spliceosome 1 Q32P51 3 5.00e-02 181 2 2 1.000 0.011 TF:M00420_0 tf 1 Factor: MEIS1A:HOXA9; motif: TGACAGKTTTAYGA; match class: 0 1 P31942,Q32P51 4 9.51e-06 13 3 2 0.667 0.154 GO:0030126 CC 1 COPI vesicle coat 1 Q9UBF2,P35606 4 1.11e-05 14 3 2 0.667 0.143 GO:0030663 CC 1 COPI-coated vesicle membrane 1 Q9UBF2,P35606 4 1.87e-05 18 3 2 0.667 0.111 GO:0030137 CC 1 COPI-coated vesicle 1 Q9UBF2,P35606 4 5.67e-05 31 3 2 0.667 0.065 GO:0006891 BP 1 intra-Golgi vesicle-mediated transport 1 Q9UBF2,P35606 4 6.40e-05 332 3 3 1.000 0.009 GO:0000139 CC 1 Golgi membrane 1 Q9UBF2,P35606,Q9NTJ5 4 7.25e-05 35 3 2 0.667 0.057 GO:0030660 CC 1 Golgi-associated vesicle membrane 1 Q9UBF2,P35606 4 7.67e-05 36 3 2 0.667 0.056 GO:0030120 CC 1 vesicle coat 1 Q9UBF2,P35606 4 1.81e-04 55 3 2 0.667 0.036 GO:0005798 CC 1 Golgi-associated vesicle 1 Q9UBF2,P35606 4 1.96e-04 482 3 3 1.000 0.006 GO:0044431 CC 1 Golgi apparatus part 1 Q9UBF2,P35606,Q9NTJ5 4 2.01e-04 58 3 2 0.667 0.034 GO:0048475 CC 1 coated membrane 1 Q9UBF2,P35606 4 2.01e-04 58 3 2 0.667 0.034 GO:0030117 CC 1 membrane coat 1 Q9UBF2,P35606 4 2.58e-04 528 3 3 1.000 0.006 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q9UBF2,P35606,Q9NTJ5 4 2.67e-04 534 3 3 1.000 0.006 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q9UBF2,P35606,Q9NTJ5 4 3.37e-04 75 3 2 0.667 0.027 GO:0006890 BP 1 retrograde vesicle-mediated transport, Golgi to ER 1 Q9UBF2,P35606 4 5.00e-04 658 3 3 1.000 0.005 GO:0044432 CC 1 endoplasmic reticulum part 1 Q9UBF2,P35606,Q9NTJ5 4 5.36e-04 73 3 2 0.667 0.027 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 Q9UBF2,P35606 4 5.65e-04 97 3 2 0.667 0.021 GO:0030662 CC 1 coated vesicle membrane 1 Q9UBF2,P35606 4 6.13e-04 78 3 2 0.667 0.026 REAC:6811434 rea 1 COPI-dependent Golgi-to-ER retrograde traffic 1 Q9UBF2,P35606 4 1.06e-03 846 3 3 1.000 0.004 GO:0005794 CC 1 Golgi apparatus 1 Q9UBF2,P35606,Q9NTJ5 4 1.15e-03 107 3 2 0.667 0.019 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 Q9UBF2,P35606 4 1.41e-03 153 3 2 0.667 0.013 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 Q9UBF2,P35606 4 1.41e-03 2 3 1 0.333 0.500 GO:0043812 MF 1 phosphatidylinositol-4-phosphate phosphatase activity 1 Q9NTJ5 4 1.43e-03 119 3 2 0.667 0.017 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 Q9UBF2,P35606 4 1.43e-03 933 3 3 1.000 0.003 GO:0005783 CC 1 endoplasmic reticulum 1 Q9UBF2,P35606,Q9NTJ5 4 1.48e-03 945 3 3 1.000 0.003 GO:0098588 CC 1 bounding membrane of organelle 1 Q9UBF2,P35606,Q9NTJ5 4 1.48e-03 2 3 1 0.333 0.500 REAC:1483248 rea 1 Synthesis of PIPs at the ER membrane 1 Q9NTJ5 4 1.54e-03 160 3 2 0.667 0.013 GO:0030135 CC 1 coated vesicle 1 Q9UBF2,P35606 4 2.03e-03 142 3 2 0.667 0.014 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 Q9UBF2,P35606 4 2.21e-03 192 3 2 0.667 0.010 GO:0030133 CC 1 transport vesicle 1 Q9UBF2,P35606 4 2.94e-03 171 3 2 0.667 0.012 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 Q9UBF2,P35606 4 3.07e-03 412 3 2 0.667 0.005 TF:M00102_0 tf 1 Factor: CDP; motif: NWNATCGATTANYNN; match class: 0 1 P35606,Q9NTJ5 4 3.26e-03 374 3 2 0.667 0.005 MI:hsa-miR-633 mi 1 MI:hsa-miR-633 1 P35606,Q9NTJ5 4 3.35e-03 379 3 2 0.667 0.005 MI:hsa-miR-654-3p mi 1 MI:hsa-miR-654-3p 1 P35606,Q9NTJ5 4 3.60e-03 245 3 2 0.667 0.008 GO:0030659 CC 1 cytoplasmic vesicle membrane 1 Q9UBF2,P35606 4 3.89e-03 255 3 2 0.667 0.008 GO:0012506 CC 1 vesicle membrane 1 Q9UBF2,P35606 4 4.62e-03 278 3 2 0.667 0.007 GO:0048193 BP 1 Golgi vesicle transport 1 Q9UBF2,P35606 4 4.83e-03 2153 3 3 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 4.83e-03 2153 3 3 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 4.96e-03 525 3 2 0.667 0.004 TF:M07140_0 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 0 1 P35606,Q9NTJ5 4 4.98e-03 1414 3 3 1.000 0.002 GO:0031090 CC 1 organelle membrane 1 Q9UBF2,P35606,Q9NTJ5 4 5.63e-03 8 3 1 0.333 0.125 GO:0034596 MF 1 phosphatidylinositol phosphate 4-phosphatase activity 1 Q9NTJ5 4 6.15e-03 248 3 2 0.667 0.008 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q9UBF2,P35606 4 6.32e-03 594 3 2 0.667 0.003 TF:M00935_1 tf 1 Factor: NF-AT; motif: NWGGAAANWN; match class: 1 1 Q9UBF2,Q9NTJ5 4 7.67e-03 2511 3 3 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 8.44e-03 12 3 1 0.333 0.083 GO:0046856 BP 1 phosphatidylinositol dephosphorylation 1 Q9NTJ5 4 8.44e-03 12 3 1 0.333 0.083 GO:0052744 MF 1 phosphatidylinositol monophosphate phosphatase activity 1 Q9NTJ5 4 8.44e-03 12 3 1 0.333 0.083 GO:0004438 MF 1 phosphatidylinositol-3-phosphatase activity 1 Q9NTJ5 4 8.70e-03 37 3 1 0.333 0.027 TF:M06085_0 tf 1 Factor: ZNF26; motif: NCTTAAATACGM; match class: 0 1 Q9NTJ5 4 9.11e-03 2659 3 3 1.000 0.001 TF:M04440_0 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 1.03e-02 44 3 1 0.333 0.023 TF:M00102_1 tf 1 Factor: CDP; motif: NWNATCGATTANYNN; match class: 1 1 P35606 4 1.11e-02 15 3 1 0.333 0.067 REAC:1660514 rea 1 Synthesis of PIPs at the Golgi membrane 1 Q9NTJ5 4 1.17e-02 444 3 2 0.667 0.005 GO:0098796 CC 1 membrane protein complex 1 Q9UBF2,P35606 4 1.24e-02 2943 3 3 1.000 0.001 TF:M01307_1 tf 1 Factor: Oct3; motif: NATGCAANNN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 1.27e-02 2971 3 3 1.000 0.001 TF:M01017_1 tf 1 Factor: Pbx-1; motif: NNATCAATCANN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 1.34e-02 19 3 1 0.333 0.053 GO:0046839 BP 1 phospholipid dephosphorylation 1 Q9NTJ5 4 1.36e-02 58 3 1 0.333 0.017 TF:M03912_0 tf 1 Factor: KLF13; motif: NTGMCACGCCCCTTTTTG; match class: 0 1 Q9UBF2 4 1.38e-02 885 3 2 0.667 0.002 TF:M07287_1 tf 1 Factor: FOXO3A; motif: NNNRTAAACANNN; match class: 1 1 Q9UBF2,P35606 4 1.38e-02 59 3 1 0.333 0.017 TF:M06072_0 tf 1 Factor: ZNF623; motif: KGGGGAAGMTGM; match class: 0 1 Q9UBF2 4 1.38e-02 59 3 1 0.333 0.017 TF:M01834_1 tf 1 Factor: Hoxd9; motif: AVNCATWAAA; match class: 1 1 Q9UBF2 4 1.47e-02 499 3 2 0.667 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q9UBF2,P35606 4 1.55e-02 3176 3 3 1.000 0.001 TF:M01020_0 tf 1 Factor: Tbx5; motif: TNAGGTGTKV; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 1.56e-02 3179 3 3 1.000 0.001 TF:M01197_0 tf 1 Factor: Elf5; motif: WNAAGGAARTW; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 1.65e-02 3239 3 3 1.000 0.001 TF:M07378_0 tf 1 Factor: cdx; motif: NNTTTATNN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 1.73e-02 993 3 2 0.667 0.002 TF:M00001_0 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 0 1 Q9UBF2,Q9NTJ5 4 1.90e-02 27 3 1 0.333 0.037 GO:0052866 MF 1 phosphatidylinositol phosphate phosphatase activity 1 Q9NTJ5 4 1.92e-02 82 3 1 0.333 0.012 TF:M06271_0 tf 1 Factor: ZNF284; motif: NGGTCRGKAAGA; match class: 0 1 Q9NTJ5 4 1.97e-02 3440 3 3 1.000 0.001 TF:M04306_1 tf 1 Factor: DPRX; motif: NNGGATTANN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 2.03e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 Q9UBF2,P35606,Q9NTJ5 4 2.07e-02 3498 3 3 1.000 0.001 TF:M07433_0 tf 1 Factor: TCF-1; motif: NNNSWWCAAAGN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 2.41e-02 103 3 1 0.333 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 Q9NTJ5 4 2.47e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 Q9UBF2,P35606,Q9NTJ5 4 2.60e-02 1225 3 2 0.667 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 Q9UBF2,Q9NTJ5 4 2.66e-02 522 3 2 0.667 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q9UBF2,P35606 4 2.69e-02 115 3 1 0.333 0.009 TF:M07103_0 tf 1 Factor: JunB; motif: NRRTGASTCAK; match class: 0 1 Q9NTJ5 4 2.70e-02 3821 3 3 1.000 0.001 TF:M04415_0 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 2.73e-02 3835 3 3 1.000 0.001 TF:M02909_0 tf 1 Factor: SOX4; motif: NNNNNAATTGTTNNNNN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 2.81e-02 3869 3 3 1.000 0.001 TF:M01718_1 tf 1 Factor: NF-AT2; motif: TTTCCWN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 2.83e-02 3879 3 3 1.000 0.001 TF:M03873_0 tf 1 Factor: HOXA10; motif: ANTTTATG; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 2.87e-02 123 3 1 0.333 0.008 TF:M04181_1 tf 1 Factor: MYF6; motif: AACARCTGTT; match class: 1 1 Q9UBF2 4 2.87e-02 123 3 1 0.333 0.008 TF:M04570_0 tf 1 Factor: MSC; motif: AACAGCTGTT; match class: 0 1 Q9UBF2 4 2.87e-02 123 3 1 0.333 0.008 TF:M04181_0 tf 1 Factor: MYF6; motif: AACARCTGTT; match class: 0 1 Q9UBF2 4 2.87e-02 123 3 1 0.333 0.008 TF:M04570_1 tf 1 Factor: MSC; motif: AACAGCTGTT; match class: 1 1 Q9UBF2 4 2.89e-02 1294 3 2 0.667 0.002 TF:M04147_0 tf 1 Factor: TFAP2A; motif: NGCCYSAGGCN; match class: 0 1 P35606,Q9NTJ5 4 2.93e-02 549 3 2 0.667 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9UBF2,P35606 4 2.98e-02 1316 3 2 0.667 0.002 TF:M04182_0 tf 1 Factor: NEUROD2; motif: RMCATATGKY; match class: 0 1 Q9UBF2,Q9NTJ5 4 3.13e-02 134 3 1 0.333 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q9UBF2 4 3.24e-02 139 3 1 0.333 0.007 TF:M05366_0 tf 1 Factor: Tbr-1; motif: TTNACACCTR; match class: 0 1 Q9NTJ5 4 3.24e-02 139 3 1 0.333 0.007 TF:M05495_0 tf 1 Factor: T-bet; motif: TTAACACCTA; match class: 0 1 Q9NTJ5 4 3.24e-02 139 3 1 0.333 0.007 TF:M05321_0 tf 1 Factor: TBR2; motif: TTNACACCTR; match class: 0 1 Q9NTJ5 4 3.24e-02 1374 3 2 0.667 0.001 TF:M00478_0 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 0 1 Q9UBF2,P35606 4 3.36e-02 759 3 2 0.667 0.003 GO:0098805 CC 1 whole membrane 1 Q9UBF2,P35606 4 3.36e-02 4107 3 3 1.000 0.001 TF:M00729_0 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 3.43e-02 147 3 1 0.333 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 P35606 4 3.49e-02 150 3 1 0.333 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 Q9UBF2 4 3.61e-02 1453 3 2 0.667 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 Q9UBF2,Q9NTJ5 4 3.67e-02 4229 3 3 1.000 0.001 TF:M01250_1 tf 1 Factor: E2F-1; motif: CGTTTCNN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 3.75e-02 4260 3 3 1.000 0.001 TF:M00474_0 tf 1 Factor: FOXO1; motif: GNNTTGTTTACNTT; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 3.79e-02 163 3 1 0.333 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 Q9UBF2 4 3.86e-02 4302 3 3 1.000 0.001 TF:M04402_1 tf 1 Factor: MIXL1; motif: NNYAATTANN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 3.94e-02 4332 3 3 1.000 0.001 TF:M04073_0 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 0 1 Q9UBF2,P35606,Q9NTJ5 4 4.00e-02 172 3 1 0.333 0.006 TF:M04314_1 tf 1 Factor: EMX2; motif: NNTAATTANN; match class: 1 1 Q9NTJ5 4 4.00e-02 4354 3 3 1.000 0.001 TF:M04334_1 tf 1 Factor: HMX2; motif: ANCAMTTAANN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 4.16e-02 179 3 1 0.333 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 P35606 4 4.22e-02 1576 3 2 0.667 0.001 TF:M00086_1 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 1 1 P35606,Q9NTJ5 4 4.30e-02 185 3 1 0.333 0.005 TF:M06608_0 tf 1 Factor: ZNF486; motif: NGRGGCTTGGGA; match class: 0 1 P35606 4 4.42e-02 1616 3 2 0.667 0.001 TF:M03833_1 tf 1 Factor: NKX3A; motif: NCACTTANTYN; match class: 1 1 Q9UBF2,P35606 4 4.44e-02 191 3 1 0.333 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 Q9NTJ5 4 4.44e-02 191 3 1 0.333 0.005 TF:M04323_1 tf 1 Factor: GBX2; motif: TAATTGNNCAATTA; match class: 1 1 Q9NTJ5 4 4.48e-02 1626 3 2 0.667 0.001 TF:M06119_0 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 0 1 Q9UBF2,Q9NTJ5 4 4.64e-02 200 3 1 0.333 0.005 TF:M07403_0 tf 1 Factor: FOXP2; motif: NWGTAAACARN; match class: 0 1 P35606 4 4.64e-02 4575 3 3 1.000 0.001 TF:M04443_1 tf 1 Factor: UNCX; motif: NYAATTAN; match class: 1 1 Q9UBF2,P35606,Q9NTJ5 4 4.78e-02 910 3 2 0.667 0.002 GO:0097708 CC 1 intracellular vesicle 1 Q9UBF2,P35606 4 4.86e-02 712 3 2 0.667 0.003 REAC:597592 rea 1 Post-translational protein modification 1 Q9UBF2,P35606 4 4.91e-02 212 3 1 0.333 0.005 TF:M05770_0 tf 1 Factor: ZNFpT1; motif: GTWTTTTCGA; match class: 0 1 Q9UBF2 4 4.94e-02 213 3 1 0.333 0.005 TF:M04417_1 tf 1 Factor: NOTO; motif: NYTAATTANN; match class: 1 1 Q9NTJ5 4 5.00e-02 11 3 1 0.333 0.091 CORUM:5230 cor 1 CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex 1 P35606 4 5.00e-02 931 3 2 0.667 0.002 GO:0031410 CC 1 cytoplasmic vesicle 1 Q9UBF2,P35606 4 5.00e-02 68 3 1 0.333 0.015 REAC:1483255 rea 1 PI Metabolism 1 Q9NTJ5 5 1.99e-03 331 3 2 0.667 0.006 TF:M07308_1 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 1 1 O60869,Q9BY44 5 4.10e-03 2 3 1 0.333 0.500 GO:0045504 MF 1 dynein heavy chain binding 1 Q9Y6G9 5 4.17e-03 481 3 2 0.667 0.004 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 O60869,Q9Y6G9 5 4.47e-03 19 3 1 0.333 0.053 TF:M05967_0 tf 1 Factor: ZFP30; motif: KGGTWTACCAAA; match class: 0 1 Q9Y6G9 5 6.15e-03 3 3 1 0.333 0.333 GO:0005850 CC 1 eukaryotic translation initiation factor 2 complex 1 Q9BY44 5 6.35e-03 27 3 1 0.333 0.037 TF:M06269_0 tf 1 Factor: ZNF569; motif: NGTGTTAAAAAA; match class: 0 1 Q9Y6G9 5 7.99e-03 34 3 1 0.333 0.029 TF:M06729_0 tf 1 Factor: ZNF282; motif: CTGGGGWAGTTG; match class: 0 1 Q9BY44 5 9.26e-03 2674 3 3 1.000 0.001 TF:M07308_0 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 1.13e-02 2861 3 3 1.000 0.001 TF:M02053_0 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 1.20e-02 2470 3 3 1.000 0.001 HPA:026010_02 hpa 1 ovary; follicle cells[Uncertain,Medium] 1 O60869,Q9Y6G9,Q9BY44 5 1.22e-02 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 O60869,Q9Y6G9,Q9BY44 5 1.27e-02 54 3 1 0.333 0.019 TF:M05980_0 tf 1 Factor: zfp64; motif: NATACGGMTC; match class: 0 1 Q9BY44 5 1.32e-02 3009 3 3 1.000 0.001 TF:M01590_1 tf 1 Factor: SMAD1; motif: NANRACAAARGN; match class: 1 1 O60869,Q9Y6G9,Q9BY44 5 1.43e-02 7 3 1 0.333 0.143 GO:0090267 BP 1 positive regulation of mitotic cell cycle spindle assembly checkpoint 1 Q9Y6G9 5 1.45e-02 62 3 1 0.333 0.016 TF:M01163_0 tf 1 Factor: Elk-1; motif: AACCGGAAGTR; match class: 0 1 Q9BY44 5 1.48e-02 63 3 1 0.333 0.016 TF:M06189_0 tf 1 Factor: ZNF91; motif: KGKTAGGRCAKA; match class: 0 1 O60869 5 1.57e-02 67 3 1 0.333 0.015 TF:M06624_0 tf 1 Factor: ZNF2; motif: NSATCGATCCGA; match class: 0 1 O60869 5 1.64e-02 8 3 1 0.333 0.125 GO:0090232 BP 1 positive regulation of spindle checkpoint 1 Q9Y6G9 5 1.66e-02 972 3 2 0.667 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 O60869,Q9BY44 5 1.73e-02 993 3 2 0.667 0.002 TF:M00001_0 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 0 1 O60869,Q9BY44 5 1.78e-02 76 3 1 0.333 0.013 TF:M01208_1 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 1 1 Q9BY44 5 1.80e-02 3335 3 3 1.000 0.001 TF:M02017_0 tf 1 Factor: HSF1; motif: GAANNTTCTRGNAN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 1.80e-02 77 3 1 0.333 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 Q9BY44 5 1.84e-02 9 3 1 0.333 0.111 GO:1901978 BP 1 positive regulation of cell cycle checkpoint 1 Q9Y6G9 5 1.85e-02 872 3 2 0.667 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 Q9Y6G9,Q9BY44 5 1.85e-02 79 3 1 0.333 0.013 TF:M03974_1 tf 1 Factor: ERF; motif: ACCGGAAGTR; match class: 1 1 Q9BY44 5 1.88e-02 1037 3 2 0.667 0.002 TF:M07281_0 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 0 1 O60869,Q9BY44 5 1.90e-02 1042 3 2 0.667 0.002 TF:M00672_0 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 0 1 Q9Y6G9,Q9BY44 5 2.16e-02 3547 3 3 1.000 0.001 TF:M00413_0 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 2.18e-02 93 3 1 0.333 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 Q9Y6G9 5 2.18e-02 93 3 1 0.333 0.011 TF:M00260_1 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 1 1 Q9BY44 5 2.18e-02 93 3 1 0.333 0.011 TF:M06674_0 tf 1 Factor: znf587; motif: NGGGRCTGATGA; match class: 0 1 Q9Y6G9 5 2.25e-02 11 3 1 0.333 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q9Y6G9 5 2.25e-02 11 3 1 0.333 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q9Y6G9 5 2.27e-02 97 3 1 0.333 0.010 TF:M07420_1 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 1 1 Q9BY44 5 2.34e-02 100 3 1 0.333 0.010 TF:M06551_0 tf 1 Factor: znf417; motif: NGGGRCTGATGA; match class: 0 1 Q9Y6G9 5 2.36e-02 3653 3 3 1.000 0.001 TF:M01247_1 tf 1 Factor: Nanog; motif: NNWNNANAACAAWRGNNNNN; match class: 1 1 O60869,Q9Y6G9,Q9BY44 5 2.41e-02 103 3 1 0.333 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q9BY44 5 2.45e-02 105 3 1 0.333 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 Q9Y6G9 5 2.50e-02 107 3 1 0.333 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 Q9BY44 5 2.66e-02 13 3 1 0.333 0.077 GO:0005868 CC 1 cytoplasmic dynein complex 1 Q9Y6G9 5 2.80e-02 120 3 1 0.333 0.008 TF:M06463_0 tf 1 Factor: ZNF595; motif: NGKGGCGGCMGM; match class: 0 1 O60869 5 2.87e-02 14 3 1 0.333 0.071 GO:0090231 BP 1 regulation of spindle checkpoint 1 Q9Y6G9 5 2.94e-02 126 3 1 0.333 0.008 TF:M00045_0 tf 1 Factor: E4BP4; motif: NRTTAYGTAAYN; match class: 0 1 Q9BY44 5 2.99e-02 1317 3 2 0.667 0.002 TF:M01208_0 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 0 1 O60869,Q9BY44 5 3.49e-02 381 3 2 0.667 0.005 MI:hsa-miR-622 mi 1 MI:hsa-miR-622 1 O60869,Q9BY44 5 3.49e-02 381 3 2 0.667 0.005 MI:hsa-miR-511 mi 1 MI:hsa-miR-511 1 O60869,Q9BY44 5 3.56e-02 153 3 1 0.333 0.007 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 O60869 5 3.58e-02 3559 3 3 1.000 0.001 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 O60869,Q9Y6G9,Q9BY44 5 3.67e-02 4229 3 3 1.000 0.001 TF:M01250_1 tf 1 Factor: E2F-1; motif: CGTTTCNN; match class: 1 1 O60869,Q9Y6G9,Q9BY44 5 3.70e-02 159 3 1 0.333 0.006 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 O60869 5 3.79e-02 397 3 2 0.667 0.005 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 O60869,Q9BY44 5 3.87e-02 4307 3 3 1.000 0.001 TF:M00172_0 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 4.02e-02 409 3 2 0.667 0.005 MI:hsa-miR-375 mi 1 MI:hsa-miR-375 1 O60869,Q9BY44 5 4.04e-02 3704 3 3 1.000 0.001 HPA:026010_01 hpa 1 ovary; follicle cells[Uncertain,Low] 1 O60869,Q9Y6G9,Q9BY44 5 4.09e-02 4387 3 3 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 4.09e-02 20 3 1 0.333 0.050 GO:0043388 BP 1 positive regulation of DNA binding 1 O60869 5 4.17e-02 4414 3 3 1.000 0.001 TF:M00188_0 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 0 1 O60869,Q9Y6G9,Q9BY44 5 4.23e-02 182 3 1 0.333 0.005 TF:M06292_0 tf 1 Factor: ZNF766; motif: NCGTGAAGGAAA; match class: 0 1 Q9BY44 5 4.27e-02 184 3 1 0.333 0.005 TF:M05438_0 tf 1 Factor: Osx; motif: WGGGCGGGTS; match class: 0 1 Q9Y6G9 5 4.37e-02 188 3 1 0.333 0.005 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 Q9BY44 5 4.45e-02 431 3 2 0.667 0.005 MI:hsa-miR-29a* mi 1 MI:hsa-miR-29a* 1 O60869,Q9BY44 5 4.48e-02 1380 3 2 0.667 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q9Y6G9,Q9BY44 5 4.50e-02 194 3 1 0.333 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 Q9Y6G9 5 4.71e-02 23 3 1 0.333 0.043 GO:0045502 MF 1 dynein binding 1 Q9Y6G9 5 4.71e-02 23 3 1 0.333 0.043 GO:0007094 BP 1 mitotic spindle assembly checkpoint 1 Q9Y6G9 5 4.72e-02 444 3 2 0.667 0.005 MI:hsa-miR-507 mi 1 MI:hsa-miR-507 1 Q9Y6G9,Q9BY44 5 4.72e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 O60869,Q9Y6G9,Q9BY44 5 4.72e-02 4602 3 3 1.000 0.001 TF:M01855_1 tf 1 Factor: AHR; motif: CACGCN; match class: 1 1 O60869,Q9Y6G9,Q9BY44 5 4.84e-02 1694 3 2 0.667 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 O60869,Q9Y6G9 5 4.86e-02 3939 3 3 1.000 0.001 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 O60869,Q9Y6G9,Q9BY44 5 4.87e-02 210 3 1 0.333 0.005 TF:M06245_0 tf 1 Factor: ZNF763; motif: NGAATAAGCCNT; match class: 0 1 O60869 5 4.91e-02 24 3 1 0.333 0.042 GO:0030286 CC 1 dynein complex 1 Q9Y6G9 5 4.91e-02 24 3 1 0.333 0.042 GO:0071173 BP 1 spindle assembly checkpoint 1 Q9Y6G9 5 5.00e-02 1723 3 2 0.667 0.001 TF:M02069_0 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 0 1 O60869,Q9BY44 5 5.00e-02 2136 3 3 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 O60869,Q9Y6G9,Q9BY44 5 5.00e-02 457 3 2 0.667 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 O60869,Q9BY44 6 3.54e-04 1 2 1 0.500 1.000 GO:0006343 BP 1 establishment of chromatin silencing 1 Q96EB6 6 3.54e-04 1 2 1 0.500 1.000 GO:0071441 BP 1 negative regulation of histone H3-K14 acetylation 1 Q96EB6 6 3.54e-04 1 2 1 0.500 1.000 GO:2000654 BP 1 regulation of cellular response to testosterone stimulus 1 Q96EB6 6 3.54e-04 1 2 1 0.500 1.000 GO:2000655 BP 1 negative regulation of cellular response to testosterone stimulus 1 Q96EB6 6 3.54e-04 1 2 1 0.500 1.000 GO:0000720 BP 1 pyrimidine dimer repair by nucleotide-excision repair 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0031392 BP 1 regulation of prostaglandin biosynthetic process 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0043398 MF 1 HLH domain binding 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:1904177 BP 1 regulation of adipose tissue development 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0006344 BP 1 maintenance of chromatin silencing 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:1904179 BP 1 positive regulation of adipose tissue development 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:2000619 BP 1 negative regulation of histone H4-K16 acetylation 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0031393 BP 1 negative regulation of prostaglandin biosynthetic process 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0045348 BP 1 positive regulation of MHC class II biosynthetic process 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0032129 MF 1 histone deacetylase activity (H3-K9 specific) 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0046969 MF 1 NAD-dependent histone deacetylase activity (H3-K9 specific) 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:2001279 BP 1 regulation of unsaturated fatty acid biosynthetic process 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0046628 BP 1 positive regulation of insulin receptor signaling pathway 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0006290 BP 1 pyrimidine dimer repair 1 Q96EB6 6 7.09e-04 2 2 1 0.500 0.500 GO:0006642 BP 1 triglyceride mobilization 1 Q96EB6 6 7.20e-04 217 2 2 1.000 0.009 GO:0006260 BP 1 DNA replication 1 Q96EB6,Q8NAP3 6 8.52e-04 236 2 2 1.000 0.008 GO:0051052 BP 1 regulation of DNA metabolic process 1 Q96EB6,Q8NAP3 6 1.06e-03 3 2 1 0.500 0.333 GO:0034390 BP 1 smooth muscle cell apoptotic process 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0090241 BP 1 negative regulation of histone H4 acetylation 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:2000111 BP 1 positive regulation of macrophage apoptotic process 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0051097 BP 1 negative regulation of helicase activity 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0033574 BP 1 response to testosterone 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0045346 BP 1 regulation of MHC class II biosynthetic process 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0071394 BP 1 cellular response to testosterone stimulus 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0045342 BP 1 MHC class II biosynthetic process 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0035356 BP 1 cellular triglyceride homeostasis 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0034391 BP 1 regulation of smooth muscle cell apoptotic process 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0090335 BP 1 regulation of brown fat cell differentiation 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:0071440 BP 1 regulation of histone H3-K14 acetylation 1 Q96EB6 6 1.06e-03 3 2 1 0.500 0.333 GO:1990254 MF 1 keratin filament binding 1 Q96EB6 6 1.08e-03 419 2 2 1.000 0.005 TF:M05469_0 tf 1 Factor: Sall1; motif: CAWTGCGYA; match class: 0 1 Q96EB6,Q8NAP3 6 1.42e-03 4 2 1 0.500 0.250 GO:0033553 CC 1 rDNA heterochromatin 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:0017136 MF 1 NAD-dependent histone deacetylase activity 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:2000481 BP 1 positive regulation of cAMP-dependent protein kinase activity 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:0070857 BP 1 regulation of bile acid biosynthetic process 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:0044154 BP 1 histone H3-K14 acetylation 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:2000774 BP 1 positive regulation of cellular senescence 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:0050872 BP 1 white fat cell differentiation 1 Q96EB6 6 1.42e-03 4 2 1 0.500 0.250 GO:0033034 BP 1 positive regulation of myeloid cell apoptotic process 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:0051574 BP 1 positive regulation of histone H3-K9 methylation 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:0034979 MF 1 NAD-dependent protein deacetylase activity 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:1904251 BP 1 regulation of bile acid metabolic process 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:2000109 BP 1 regulation of macrophage apoptotic process 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:0090343 BP 1 positive regulation of cell aging 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:2000773 BP 1 negative regulation of cellular senescence 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:0090400 BP 1 stress-induced premature senescence 1 Q96EB6 6 1.77e-03 5 2 1 0.500 0.200 GO:2000618 BP 1 regulation of histone H4-K16 acetylation 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0000012 BP 1 single strand break repair 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:2000480 BP 1 negative regulation of cAMP-dependent protein kinase activity 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0010934 BP 1 macrophage cytokine production 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0071888 BP 1 macrophage apoptotic process 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0035358 BP 1 regulation of peroxisome proliferator activated receptor signaling pathway 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0033210 BP 1 leptin-mediated signaling pathway 1 Q96EB6 6 2.13e-03 6 2 1 0.500 0.167 GO:0055089 BP 1 fatty acid homeostasis 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0031937 BP 1 positive regulation of chromatin silencing 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0032071 BP 1 regulation of endodeoxyribonuclease activity 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0005677 CC 1 chromatin silencing complex 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:1900078 BP 1 positive regulation of cellular response to insulin stimulus 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0050873 BP 1 brown fat cell differentiation 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0006925 BP 1 inflammatory cell apoptotic process 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0044320 BP 1 cellular response to leptin stimulus 1 Q96EB6 6 2.48e-03 7 2 1 0.500 0.143 GO:0034983 BP 1 peptidyl-lysine deacetylation 1 Q96EB6 6 2.83e-03 18 2 1 0.500 0.056 TF:M06374_0 tf 1 Factor: ZNF626; motif: CCTGCTGAWGSA; match class: 0 1 Q8NAP3 6 2.83e-03 8 2 1 0.500 0.125 GO:0061082 BP 1 myeloid leukocyte cytokine production 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0019215 MF 1 intermediate filament binding 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0090344 BP 1 negative regulation of cell aging 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0033032 BP 1 regulation of myeloid cell apoptotic process 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0044321 BP 1 response to leptin 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0033158 BP 1 regulation of protein import into nucleus, translocation 1 Q96EB6 6 2.83e-03 8 2 1 0.500 0.125 GO:0032070 BP 1 regulation of deoxyribonuclease activity 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0051095 BP 1 regulation of helicase activity 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0045717 BP 1 negative regulation of fatty acid biosynthetic process 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0070914 BP 1 UV-damage excision repair 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0035067 BP 1 negative regulation of histone acetylation 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0060766 BP 1 negative regulation of androgen receptor signaling pathway 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0060612 BP 1 adipose tissue development 1 Q96EB6 6 3.19e-03 9 2 1 0.500 0.111 GO:0090239 BP 1 regulation of histone H4 acetylation 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:0043518 BP 1 negative regulation of DNA damage response, signal transduction by p53 class mediator 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:2000479 BP 1 regulation of cAMP-dependent protein kinase activity 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:0033028 BP 1 myeloid cell apoptotic process 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:0035357 BP 1 peroxisome proliferator activated receptor signaling pathway 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:0000183 BP 1 chromatin silencing at rDNA 1 Q96EB6 6 3.54e-03 10 2 1 0.500 0.100 GO:2000757 BP 1 negative regulation of peptidyl-lysine acetylation 1 Q96EB6 6 3.54e-03 758 2 2 1.000 0.003 TF:M04318_1 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 1 1 Q96EB6,Q8NAP3 6 3.90e-03 11 2 1 0.500 0.091 GO:1901984 BP 1 negative regulation of protein acetylation 1 Q96EB6 6 3.90e-03 11 2 1 0.500 0.091 GO:1902166 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q96EB6 6 3.90e-03 11 2 1 0.500 0.091 GO:1902165 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q96EB6 6 4.08e-03 516 2 2 1.000 0.004 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 Q96EB6,Q8NAP3 6 4.16e-03 821 2 2 1.000 0.002 TF:M02013_1 tf 1 Factor: HNF-1alpha; motif: RGTTAATNWTT; match class: 1 1 Q96EB6,Q8NAP3 6 4.25e-03 12 2 1 0.500 0.083 GO:0001516 BP 1 prostaglandin biosynthetic process 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0070932 BP 1 histone H3 deacetylation 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0010657 BP 1 muscle cell apoptotic process 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0046457 BP 1 prostanoid biosynthetic process 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0010660 BP 1 regulation of muscle cell apoptotic process 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0010875 BP 1 positive regulation of cholesterol efflux 1 Q96EB6 6 4.25e-03 12 2 1 0.500 0.083 GO:0051570 BP 1 regulation of histone H3-K9 methylation 1 Q96EB6 6 4.60e-03 13 2 1 0.500 0.077 GO:2000108 BP 1 positive regulation of leukocyte apoptotic process 1 Q96EB6 6 4.60e-03 13 2 1 0.500 0.077 GO:1902254 BP 1 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 Q96EB6 6 4.60e-03 13 2 1 0.500 0.077 GO:0055090 BP 1 acylglycerol homeostasis 1 Q96EB6 6 4.60e-03 13 2 1 0.500 0.077 GO:0030225 BP 1 macrophage differentiation 1 Q96EB6 6 4.60e-03 13 2 1 0.500 0.077 GO:0070328 BP 1 triglyceride homeostasis 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0032376 BP 1 positive regulation of cholesterol transport 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0051019 MF 1 mitogen-activated protein kinase binding 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0010874 BP 1 regulation of cholesterol efflux 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0045922 BP 1 negative regulation of fatty acid metabolic process 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0032373 BP 1 positive regulation of sterol transport 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:1902253 BP 1 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 Q96EB6 6 4.96e-03 14 2 1 0.500 0.071 GO:0005719 CC 1 nuclear euchromatin 1 Q96EB6 6 5.31e-03 15 2 1 0.500 0.067 GO:2000772 BP 1 regulation of cellular senescence 1 Q96EB6 6 5.31e-03 15 2 1 0.500 0.067 GO:0006346 BP 1 methylation-dependent chromatin silencing 1 Q96EB6 6 5.31e-03 15 2 1 0.500 0.067 GO:0043425 MF 1 bHLH transcription factor binding 1 Q96EB6 6 5.31e-03 15 2 1 0.500 0.067 GO:1902176 BP 1 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 Q96EB6 6 5.37e-03 592 2 2 1.000 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q96EB6,Q8NAP3 6 5.66e-03 16 2 1 0.500 0.062 GO:0008327 MF 1 methyl-CpG binding 1 Q8NAP3 6 5.66e-03 16 2 1 0.500 0.062 GO:0006699 BP 1 bile acid biosynthetic process 1 Q96EB6 6 5.66e-03 16 2 1 0.500 0.062 GO:0003950 MF 1 NAD+ ADP-ribosyltransferase activity 1 Q96EB6 6 5.66e-03 16 2 1 0.500 0.062 GO:0051567 BP 1 histone H3-K9 methylation 1 Q96EB6 6 5.66e-03 16 2 1 0.500 0.062 GO:0035098 CC 1 ESC/E(Z) complex 1 Q96EB6 6 5.66e-03 16 2 1 0.500 0.062 GO:0006693 BP 1 prostaglandin metabolic process 1 Q96EB6 6 5.66e-03 16 2 1 0.500 0.062 GO:0006692 BP 1 prostanoid metabolic process 1 Q96EB6 6 5.88e-03 619 2 2 1.000 0.003 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 Q96EB6,Q8NAP3 6 5.95e-03 623 2 2 1.000 0.003 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 Q96EB6,Q8NAP3 6 6.02e-03 17 2 1 0.500 0.059 GO:0000791 CC 1 euchromatin 1 Q96EB6 6 6.12e-03 632 2 2 1.000 0.003 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 Q96EB6,Q8NAP3 6 6.37e-03 18 2 1 0.500 0.056 GO:0005720 CC 1 nuclear heterochromatin 1 Q96EB6 6 6.42e-03 647 2 2 1.000 0.003 GO:0042802 MF 1 identical protein binding 1 Q96EB6,Q8NAP3 6 6.73e-03 19 2 1 0.500 0.053 GO:0042304 BP 1 regulation of fatty acid biosynthetic process 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:1901797 BP 1 negative regulation of signal transduction by p53 class mediator 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:0090342 BP 1 regulation of cell aging 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:1901655 BP 1 cellular response to ketone 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:0031935 BP 1 regulation of chromatin silencing 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:0032069 BP 1 regulation of nuclease activity 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:1901570 BP 1 fatty acid derivative biosynthetic process 1 Q96EB6 6 6.73e-03 19 2 1 0.500 0.053 GO:0046456 BP 1 icosanoid biosynthetic process 1 Q96EB6 6 6.82e-03 667 2 2 1.000 0.003 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 Q96EB6,Q8NAP3 6 6.88e-03 670 2 2 1.000 0.003 GO:0006259 BP 1 DNA metabolic process 1 Q96EB6,Q8NAP3 6 7.08e-03 20 2 1 0.500 0.050 GO:0032370 BP 1 positive regulation of lipid transport 1 Q96EB6 6 7.08e-03 20 2 1 0.500 0.050 GO:0060765 BP 1 regulation of androgen receptor signaling pathway 1 Q96EB6 6 7.08e-03 20 2 1 0.500 0.050 GO:0006471 BP 1 protein ADP-ribosylation 1 Q96EB6 6 7.08e-03 20 2 1 0.500 0.050 GO:0055081 BP 1 anion homeostasis 1 Q96EB6 6 7.43e-03 21 2 1 0.500 0.048 GO:0061647 BP 1 histone H3-K9 modification 1 Q96EB6 6 7.43e-03 21 2 1 0.500 0.048 GO:0008206 BP 1 bile acid metabolic process 1 Q96EB6 6 7.43e-03 21 2 1 0.500 0.048 GO:0050810 BP 1 regulation of steroid biosynthetic process 1 Q96EB6 6 7.43e-03 21 2 1 0.500 0.048 GO:1902230 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 Q96EB6 6 7.43e-03 21 2 1 0.500 0.048 GO:0043516 BP 1 regulation of DNA damage response, signal transduction by p53 class mediator 1 Q96EB6 6 7.79e-03 22 2 1 0.500 0.045 GO:0031648 BP 1 protein destabilization 1 Q96EB6 6 7.79e-03 22 2 1 0.500 0.045 GO:1902175 BP 1 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 Q96EB6 6 7.79e-03 22 2 1 0.500 0.045 GO:0051898 BP 1 negative regulation of protein kinase B signaling 1 Q96EB6 6 7.79e-03 22 2 1 0.500 0.045 GO:0033144 BP 1 negative regulation of intracellular steroid hormone receptor signaling pathway 1 Q96EB6 6 7.79e-03 22 2 1 0.500 0.045 GO:0031057 BP 1 negative regulation of histone modification 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:0031062 BP 1 positive regulation of histone methylation 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:0045599 BP 1 negative regulation of fat cell differentiation 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:1900408 BP 1 negative regulation of cellular response to oxidative stress 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:1903202 BP 1 negative regulation of oxidative stress-induced cell death 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:0090568 CC 1 nuclear transcriptional repressor complex 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:1902883 BP 1 negative regulation of response to oxidative stress 1 Q96EB6 6 8.14e-03 23 2 1 0.500 0.043 GO:0005637 CC 1 nuclear inner membrane 1 Q96EB6 6 8.42e-03 741 2 2 1.000 0.003 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 Q96EB6,Q8NAP3 6 8.42e-03 741 2 2 1.000 0.003 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 Q96EB6,Q8NAP3 6 8.49e-03 24 2 1 0.500 0.042 GO:0043984 BP 1 histone H4-K16 acetylation 1 Q96EB6 6 8.49e-03 24 2 1 0.500 0.042 GO:1902229 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 Q96EB6 6 8.70e-03 753 2 2 1.000 0.003 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 Q96EB6,Q8NAP3 6 8.84e-03 1197 2 2 1.000 0.002 TF:M04405_0 tf 1 Factor: MSX1; motif: NCAATTAN; match class: 0 1 Q96EB6,Q8NAP3 6 8.85e-03 25 2 1 0.500 0.040 GO:0046626 BP 1 regulation of insulin receptor signaling pathway 1 Q96EB6 6 8.85e-03 25 2 1 0.500 0.040 GO:0032374 BP 1 regulation of cholesterol transport 1 Q96EB6 6 8.85e-03 25 2 1 0.500 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 Q96EB6 6 8.85e-03 25 2 1 0.500 0.040 GO:0032371 BP 1 regulation of sterol transport 1 Q96EB6 6 8.91e-03 762 2 2 1.000 0.003 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 Q96EB6,Q8NAP3 6 8.94e-03 57 2 1 0.500 0.018 TF:M01650_0 tf 1 Factor: PNR; motif: RAGRTCAAARRTCA; match class: 0 1 Q8NAP3 6 8.98e-03 765 2 2 1.000 0.003 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 Q96EB6,Q8NAP3 6 9.20e-03 26 2 1 0.500 0.038 GO:0000060 BP 1 protein import into nucleus, translocation 1 Q96EB6 6 9.20e-03 26 2 1 0.500 0.038 GO:0042771 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q96EB6 6 9.55e-03 27 2 1 0.500 0.037 GO:0010883 BP 1 regulation of lipid storage 1 Q96EB6 6 9.55e-03 27 2 1 0.500 0.037 GO:0032007 BP 1 negative regulation of TOR signaling 1 Q96EB6 6 9.60e-03 791 2 2 1.000 0.003 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 Q96EB6,Q8NAP3 6 9.67e-03 794 2 2 1.000 0.003 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 Q96EB6,Q8NAP3 6 9.91e-03 28 2 1 0.500 0.036 GO:0002821 BP 1 positive regulation of adaptive immune response 1 Q96EB6 6 9.91e-03 28 2 1 0.500 0.036 GO:0006636 BP 1 unsaturated fatty acid biosynthetic process 1 Q96EB6 6 1.03e-02 29 2 1 0.500 0.034 GO:0014068 BP 1 positive regulation of phosphatidylinositol 3-kinase signaling 1 Q96EB6 6 1.04e-02 822 2 2 1.000 0.002 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 Q96EB6,Q8NAP3 6 1.06e-02 30 2 1 0.500 0.033 GO:0016239 BP 1 positive regulation of macroautophagy 1 Q96EB6 6 1.06e-02 30 2 1 0.500 0.033 GO:1900076 BP 1 regulation of cellular response to insulin stimulus 1 Q96EB6 6 1.06e-02 30 2 1 0.500 0.033 GO:1905268 BP 1 negative regulation of chromatin organization 1 Q96EB6 6 1.06e-02 30 2 1 0.500 0.033 GO:0033344 BP 1 cholesterol efflux 1 Q96EB6 6 1.06e-02 30 2 1 0.500 0.033 GO:0035065 BP 1 regulation of histone acetylation 1 Q96EB6 6 1.07e-02 834 2 2 1.000 0.002 GO:0009890 BP 1 negative regulation of biosynthetic process 1 Q96EB6,Q8NAP3 6 1.10e-02 31 2 1 0.500 0.032 GO:2000756 BP 1 regulation of peptidyl-lysine acetylation 1 Q96EB6 6 1.10e-02 31 2 1 0.500 0.032 GO:0008631 BP 1 intrinsic apoptotic signaling pathway in response to oxidative stress 1 Q96EB6 6 1.11e-02 852 2 2 1.000 0.002 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 Q96EB6,Q8NAP3 6 1.13e-02 32 2 1 0.500 0.031 GO:0002367 BP 1 cytokine production involved in immune response 1 Q96EB6 6 1.14e-02 861 2 2 1.000 0.002 GO:0010629 BP 1 negative regulation of gene expression 1 Q96EB6,Q8NAP3 6 1.17e-02 33 2 1 0.500 0.030 GO:0001938 BP 1 positive regulation of endothelial cell proliferation 1 Q96EB6 6 1.17e-02 33 2 1 0.500 0.030 GO:1901654 BP 1 response to ketone 1 Q96EB6 6 1.17e-02 33 2 1 0.500 0.030 GO:0070301 BP 1 cellular response to hydrogen peroxide 1 Q96EB6 6 1.17e-02 33 2 1 0.500 0.030 GO:0090398 BP 1 cellular senescence 1 Q96EB6 6 1.20e-02 34 2 1 0.500 0.029 GO:1901983 BP 1 regulation of protein acetylation 1 Q96EB6 6 1.20e-02 34 2 1 0.500 0.029 GO:0071479 BP 1 cellular response to ionizing radiation 1 Q96EB6 6 1.20e-02 34 2 1 0.500 0.029 GO:1903201 BP 1 regulation of oxidative stress-induced cell death 1 Q96EB6 6 1.20e-02 34 2 1 0.500 0.029 GO:0031060 BP 1 regulation of histone methylation 1 Q96EB6 6 1.20e-02 34 2 1 0.500 0.029 GO:0019218 BP 1 regulation of steroid metabolic process 1 Q96EB6 6 1.21e-02 22 2 1 0.500 0.045 REAC:427359 rea 1 SIRT1 negatively regulates rRNA Expression 1 Q96EB6 6 1.23e-02 896 2 2 1.000 0.002 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q96EB6,Q8NAP3 6 1.24e-02 79 2 1 0.500 0.013 TF:M00105_0 tf 1 Factor: CDP; motif: CACCRATANNTATBG; match class: 0 1 Q96EB6 6 1.24e-02 35 2 1 0.500 0.029 GO:0042632 BP 1 cholesterol homeostasis 1 Q96EB6 6 1.24e-02 35 2 1 0.500 0.029 GO:0055092 BP 1 sterol homeostasis 1 Q96EB6 6 1.24e-02 35 2 1 0.500 0.029 GO:0045739 BP 1 positive regulation of DNA repair 1 Q96EB6 6 1.27e-02 23 2 1 0.500 0.043 REAC:1368082 rea 1 RORA activates gene expression 1 Q96EB6 6 1.27e-02 36 2 1 0.500 0.028 GO:2000106 BP 1 regulation of leukocyte apoptotic process 1 Q96EB6 6 1.30e-02 922 2 2 1.000 0.002 GO:0010628 BP 1 positive regulation of gene expression 1 Q96EB6,Q8NAP3 6 1.31e-02 37 2 1 0.500 0.027 GO:0043124 BP 1 negative regulation of I-kappaB kinase/NF-kappaB signaling 1 Q96EB6 6 1.31e-02 37 2 1 0.500 0.027 GO:0004407 MF 1 histone deacetylase activity 1 Q96EB6 6 1.31e-02 37 2 1 0.500 0.027 GO:0019915 BP 1 lipid storage 1 Q96EB6 6 1.34e-02 933 2 2 1.000 0.002 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 Q96EB6,Q8NAP3 6 1.34e-02 38 2 1 0.500 0.026 GO:1903845 BP 1 negative regulation of cellular response to transforming growth factor beta stimulus 1 Q96EB6 6 1.34e-02 38 2 1 0.500 0.026 GO:0033558 MF 1 protein deacetylase activity 1 Q96EB6 6 1.34e-02 38 2 1 0.500 0.026 GO:0030512 BP 1 negative regulation of transforming growth factor beta receptor signaling pathway 1 Q96EB6 6 1.38e-02 39 2 1 0.500 0.026 GO:0000792 CC 1 heterochromatin 1 Q96EB6 6 1.40e-02 956 2 2 1.000 0.002 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q96EB6,Q8NAP3 6 1.41e-02 90 2 1 0.500 0.011 TF:M06087_0 tf 1 Factor: ZNF21; motif: NANTCCTAAAGA; match class: 0 1 Q96EB6 6 1.41e-02 40 2 1 0.500 0.025 GO:2001021 BP 1 negative regulation of response to DNA damage stimulus 1 Q96EB6 6 1.41e-02 40 2 1 0.500 0.025 GO:1900407 BP 1 regulation of cellular response to oxidative stress 1 Q96EB6 6 1.41e-02 40 2 1 0.500 0.025 GO:0045833 BP 1 negative regulation of lipid metabolic process 1 Q96EB6 6 1.44e-02 970 2 2 1.000 0.002 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q96EB6,Q8NAP3 6 1.45e-02 971 2 2 1.000 0.002 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q96EB6,Q8NAP3 6 1.49e-02 42 2 1 0.500 0.024 GO:1902882 BP 1 regulation of response to oxidative stress 1 Q96EB6 6 1.49e-02 42 2 1 0.500 0.024 GO:0016763 MF 1 transferase activity, transferring pentosyl groups 1 Q96EB6 6 1.49e-02 42 2 1 0.500 0.024 GO:0032922 BP 1 circadian regulation of gene expression 1 Q96EB6 6 1.51e-02 993 2 2 1.000 0.002 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q96EB6,Q8NAP3 6 1.52e-02 43 2 1 0.500 0.023 GO:0032368 BP 1 regulation of lipid transport 1 Q96EB6 6 1.52e-02 43 2 1 0.500 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 Q96EB6 6 1.52e-02 43 2 1 0.500 0.023 GO:0072332 BP 1 intrinsic apoptotic signaling pathway by p53 class mediator 1 Q96EB6 6 1.52e-02 43 2 1 0.500 0.023 GO:0031519 CC 1 PcG protein complex 1 Q96EB6 6 1.52e-02 43 2 1 0.500 0.023 GO:0071887 BP 1 leukocyte apoptotic process 1 Q96EB6 6 1.52e-02 43 2 1 0.500 0.023 GO:0033143 BP 1 regulation of intracellular steroid hormone receptor signaling pathway 1 Q96EB6 6 1.53e-02 98 2 1 0.500 0.010 TF:M07233_1 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 1 1 Q96EB6 6 1.55e-02 99 2 1 0.500 0.010 TF:M04162_0 tf 1 Factor: BHLHE40; motif: NKCACGTGMC; match class: 0 1 Q96EB6 6 1.55e-02 99 2 1 0.500 0.010 TF:M04188_0 tf 1 Factor: SREBF2; motif: ATCACGTGAY; match class: 0 1 Q96EB6 6 1.56e-02 44 2 1 0.500 0.023 GO:0036473 BP 1 cell death in response to oxidative stress 1 Q96EB6 6 1.56e-02 44 2 1 0.500 0.023 GO:0042542 BP 1 response to hydrogen peroxide 1 Q96EB6 6 1.56e-02 44 2 1 0.500 0.023 GO:0016575 BP 1 histone deacetylation 1 Q96EB6 6 1.56e-02 44 2 1 0.500 0.023 GO:0060968 BP 1 regulation of gene silencing 1 Q96EB6 6 1.59e-02 45 2 1 0.500 0.022 GO:0010906 BP 1 regulation of glucose metabolic process 1 Q96EB6 6 1.59e-02 45 2 1 0.500 0.022 GO:0019217 BP 1 regulation of fatty acid metabolic process 1 Q96EB6 6 1.59e-02 45 2 1 0.500 0.022 GO:0032088 BP 1 negative regulation of NF-kappaB transcription factor activity 1 Q96EB6 6 1.59e-02 45 2 1 0.500 0.022 GO:0019213 MF 1 deacetylase activity 1 Q96EB6 6 1.63e-02 46 2 1 0.500 0.022 GO:0045598 BP 1 regulation of fat cell differentiation 1 Q96EB6 6 1.63e-02 46 2 1 0.500 0.022 GO:0002819 BP 1 regulation of adaptive immune response 1 Q96EB6 6 1.67e-02 1 2 1 0.500 1.000 CORUM:2592 cor 1 SIRT1 homotrimer complex 1 Q96EB6 6 1.73e-02 49 2 1 0.500 0.020 GO:0034644 BP 1 cellular response to UV 1 Q96EB6 6 1.73e-02 49 2 1 0.500 0.020 GO:0030301 BP 1 cholesterol transport 1 Q96EB6 6 1.77e-02 50 2 1 0.500 0.020 GO:0006690 BP 1 icosanoid metabolic process 1 Q96EB6 6 1.77e-02 50 2 1 0.500 0.020 GO:1901568 BP 1 fatty acid derivative metabolic process 1 Q96EB6 6 1.77e-02 50 2 1 0.500 0.020 GO:0002039 MF 1 p53 binding 1 Q96EB6 6 1.77e-02 50 2 1 0.500 0.020 GO:0007569 BP 1 cell aging 1 Q96EB6 6 1.80e-02 51 2 1 0.500 0.020 GO:0015918 BP 1 sterol transport 1 Q96EB6 6 1.80e-02 51 2 1 0.500 0.020 GO:0043966 BP 1 histone H3 acetylation 1 Q96EB6 6 1.84e-02 52 2 1 0.500 0.019 GO:0016605 CC 1 PML body 1 Q96EB6 6 1.84e-02 52 2 1 0.500 0.019 GO:0031058 BP 1 positive regulation of histone modification 1 Q96EB6 6 1.84e-02 52 2 1 0.500 0.019 GO:0045766 BP 1 positive regulation of angiogenesis 1 Q96EB6 6 1.86e-02 1737 2 2 1.000 0.001 TF:M01011_1 tf 1 Factor: HNF1; motif: NNNNGNTAAWNATTAACYNNN; match class: 1 1 Q96EB6,Q8NAP3 6 1.87e-02 53 2 1 0.500 0.019 GO:0043967 BP 1 histone H4 acetylation 1 Q96EB6 6 1.87e-02 53 2 1 0.500 0.019 GO:0030521 BP 1 androgen receptor signaling pathway 1 Q96EB6 6 1.87e-02 53 2 1 0.500 0.019 GO:0001936 BP 1 regulation of endothelial cell proliferation 1 Q96EB6 6 1.87e-02 53 2 1 0.500 0.019 GO:0006342 BP 1 chromatin silencing 1 Q96EB6 6 1.91e-02 122 2 1 0.500 0.008 TF:M04178_0 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 0 1 Q96EB6 6 1.91e-02 54 2 1 0.500 0.019 GO:0090101 BP 1 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q96EB6 6 1.91e-02 54 2 1 0.500 0.019 GO:2001022 BP 1 positive regulation of response to DNA damage stimulus 1 Q96EB6 6 1.91e-02 54 2 1 0.500 0.019 GO:0006476 BP 1 protein deacetylation 1 Q96EB6 6 1.98e-02 56 2 1 0.500 0.018 GO:0034968 BP 1 histone lysine methylation 1 Q96EB6 6 2.01e-02 57 2 1 0.500 0.018 GO:1905269 BP 1 positive regulation of chromatin organization 1 Q96EB6 6 2.05e-02 58 2 1 0.500 0.017 GO:0035601 BP 1 protein deacylation 1 Q96EB6 6 2.05e-02 58 2 1 0.500 0.017 GO:2001243 BP 1 negative regulation of intrinsic apoptotic signaling pathway 1 Q96EB6 6 2.05e-02 58 2 1 0.500 0.017 GO:0006641 BP 1 triglyceride metabolic process 1 Q96EB6 6 2.05e-02 58 2 1 0.500 0.017 GO:0098732 BP 1 macromolecule deacylation 1 Q96EB6 6 2.05e-02 58 2 1 0.500 0.017 GO:0002440 BP 1 production of molecular mediator of immune response 1 Q96EB6 6 2.08e-02 59 2 1 0.500 0.017 GO:0017015 BP 1 regulation of transforming growth factor beta receptor signaling pathway 1 Q96EB6 6 2.08e-02 59 2 1 0.500 0.017 GO:0032006 BP 1 regulation of TOR signaling 1 Q96EB6 6 2.08e-02 59 2 1 0.500 0.017 GO:0050679 BP 1 positive regulation of epithelial cell proliferation 1 Q96EB6 6 2.08e-02 59 2 1 0.500 0.017 GO:1903844 BP 1 regulation of cellular response to transforming growth factor beta stimulus 1 Q96EB6 6 2.08e-02 59 2 1 0.500 0.017 GO:0010675 BP 1 regulation of cellular carbohydrate metabolic process 1 Q96EB6 6 2.12e-02 60 2 1 0.500 0.017 GO:0051896 BP 1 regulation of protein kinase B signaling 1 Q96EB6 6 2.12e-02 60 2 1 0.500 0.017 GO:0010508 BP 1 positive regulation of autophagy 1 Q96EB6 6 2.12e-02 60 2 1 0.500 0.017 GO:0007568 BP 1 aging 1 Q96EB6 6 2.13e-02 1177 2 2 1.000 0.002 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q96EB6,Q8NAP3 6 2.16e-02 61 2 1 0.500 0.016 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 Q96EB6 6 2.16e-02 61 2 1 0.500 0.016 GO:0001935 BP 1 endothelial cell proliferation 1 Q96EB6 6 2.16e-02 61 2 1 0.500 0.016 GO:1904018 BP 1 positive regulation of vasculature development 1 Q96EB6 6 2.19e-02 62 2 1 0.500 0.016 GO:0016811 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1 Q96EB6 6 2.23e-02 63 2 1 0.500 0.016 GO:0090288 BP 1 negative regulation of cellular response to growth factor stimulus 1 Q96EB6 6 2.23e-02 143 2 1 0.500 0.007 TF:M04202_0 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 0 1 Q8NAP3 6 2.25e-02 1212 2 2 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 Q96EB6,Q8NAP3 6 2.26e-02 64 2 1 0.500 0.016 GO:0017053 CC 1 transcriptional repressor complex 1 Q96EB6 6 2.26e-02 64 2 1 0.500 0.016 GO:0061448 BP 1 connective tissue development 1 Q96EB6 6 2.30e-02 65 2 1 0.500 0.015 GO:0006633 BP 1 fatty acid biosynthetic process 1 Q96EB6 6 2.30e-02 65 2 1 0.500 0.015 GO:0034614 BP 1 cellular response to reactive oxygen species 1 Q96EB6 6 2.30e-02 65 2 1 0.500 0.015 GO:0018022 BP 1 peptidyl-lysine methylation 1 Q96EB6 6 2.33e-02 66 2 1 0.500 0.015 GO:0033559 BP 1 unsaturated fatty acid metabolic process 1 Q96EB6 6 2.33e-02 66 2 1 0.500 0.015 GO:0006282 BP 1 regulation of DNA repair 1 Q96EB6 6 2.33e-02 66 2 1 0.500 0.015 GO:0009267 BP 1 cellular response to starvation 1 Q96EB6 6 2.37e-02 67 2 1 0.500 0.015 GO:0000731 BP 1 DNA synthesis involved in DNA repair 1 Q96EB6 6 2.37e-02 67 2 1 0.500 0.015 GO:0043491 BP 1 protein kinase B signaling 1 Q96EB6 6 2.37e-02 67 2 1 0.500 0.015 GO:0031929 BP 1 TOR signaling 1 Q96EB6 6 2.40e-02 68 2 1 0.500 0.015 GO:0035097 CC 1 histone methyltransferase complex 1 Q96EB6 6 2.40e-02 68 2 1 0.500 0.015 GO:0046890 BP 1 regulation of lipid biosynthetic process 1 Q96EB6 6 2.40e-02 68 2 1 0.500 0.015 GO:0071482 BP 1 cellular response to light stimulus 1 Q96EB6 6 2.44e-02 69 2 1 0.500 0.014 GO:0045814 BP 1 negative regulation of gene expression, epigenetic 1 Q96EB6 6 2.44e-02 69 2 1 0.500 0.014 GO:0055088 BP 1 lipid homeostasis 1 Q96EB6 6 2.44e-02 69 2 1 0.500 0.014 GO:0002573 BP 1 myeloid leukocyte differentiation 1 Q96EB6 6 2.45e-02 54 2 1 0.500 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 Q96EB6 6 2.47e-02 70 2 1 0.500 0.014 GO:0006639 BP 1 acylglycerol metabolic process 1 Q96EB6 6 2.47e-02 70 2 1 0.500 0.014 GO:0071901 BP 1 negative regulation of protein serine/threonine kinase activity 1 Q96EB6 6 2.47e-02 70 2 1 0.500 0.014 GO:0006638 BP 1 neutral lipid metabolic process 1 Q96EB6 6 2.54e-02 72 2 1 0.500 0.014 GO:0016571 BP 1 histone methylation 1 Q96EB6 6 2.54e-02 72 2 1 0.500 0.014 GO:0071456 BP 1 cellular response to hypoxia 1 Q96EB6 6 2.54e-02 72 2 1 0.500 0.014 GO:0042594 BP 1 response to starvation 1 Q96EB6 6 2.58e-02 73 2 1 0.500 0.014 GO:1900034 BP 1 regulation of cellular response to heat 1 Q96EB6 6 2.58e-02 57 2 1 0.500 0.018 KEGG:04213 keg 1 Longevity regulating pathway - multiple species 1 Q96EB6 6 2.63e-02 1310 2 2 1.000 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 Q96EB6,Q8NAP3 6 2.65e-02 75 2 1 0.500 0.013 GO:0036294 BP 1 cellular response to decreased oxygen levels 1 Q96EB6 6 2.65e-02 75 2 1 0.500 0.013 GO:0006694 BP 1 steroid biosynthetic process 1 Q96EB6 6 2.65e-02 75 2 1 0.500 0.013 GO:0043280 BP 1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 Q96EB6 6 2.66e-02 1317 2 2 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 Q96EB6,Q8NAP3 6 2.68e-02 76 2 1 0.500 0.013 GO:0006275 BP 1 regulation of DNA replication 1 Q8NAP3 6 2.68e-02 172 2 1 0.500 0.006 TF:M00006_1 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 1 1 Q96EB6 6 2.72e-02 77 2 1 0.500 0.013 GO:0031056 BP 1 regulation of histone modification 1 Q96EB6 6 2.72e-02 77 2 1 0.500 0.013 GO:0006109 BP 1 regulation of carbohydrate metabolic process 1 Q96EB6 6 2.79e-02 79 2 1 0.500 0.013 GO:0008286 BP 1 insulin receptor signaling pathway 1 Q96EB6 6 2.79e-02 79 2 1 0.500 0.013 GO:0010212 BP 1 response to ionizing radiation 1 Q96EB6 6 2.79e-02 79 2 1 0.500 0.013 GO:0071453 BP 1 cellular response to oxygen levels 1 Q96EB6 6 2.82e-02 80 2 1 0.500 0.013 GO:0033500 BP 1 carbohydrate homeostasis 1 Q96EB6 6 2.82e-02 80 2 1 0.500 0.013 GO:0042593 BP 1 glucose homeostasis 1 Q96EB6 6 2.86e-02 81 2 1 0.500 0.012 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 Q96EB6 6 2.87e-02 184 2 1 0.500 0.005 TF:M00998_1 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 1 1 Q8NAP3 6 2.89e-02 82 2 1 0.500 0.012 GO:0045444 BP 1 fat cell differentiation 1 Q96EB6 6 2.89e-02 82 2 1 0.500 0.012 GO:0043433 BP 1 negative regulation of sequence-specific DNA binding transcription factor activity 1 Q96EB6 6 2.93e-02 83 2 1 0.500 0.012 GO:0072562 CC 1 blood microparticle 1 Q8NAP3 6 2.93e-02 83 2 1 0.500 0.012 GO:2001056 BP 1 positive regulation of cysteine-type endopeptidase activity 1 Q96EB6 6 2.93e-02 83 2 1 0.500 0.012 GO:0031669 BP 1 cellular response to nutrient levels 1 Q96EB6 6 3.00e-02 85 2 1 0.500 0.012 GO:0034605 BP 1 cellular response to heat 1 Q96EB6 6 3.02e-02 2213 2 2 1.000 0.001 TF:M00724_1 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 1 1 Q96EB6,Q8NAP3 6 3.07e-02 87 2 1 0.500 0.011 GO:0030330 BP 1 DNA damage response, signal transduction by p53 class mediator 1 Q96EB6 6 3.07e-02 87 2 1 0.500 0.011 GO:0034708 CC 1 methyltransferase complex 1 Q96EB6 6 3.11e-02 1424 2 2 1.000 0.001 GO:0009892 BP 1 negative regulation of metabolic process 1 Q96EB6,Q8NAP3 6 3.18e-02 90 2 1 0.500 0.011 GO:0030518 BP 1 intracellular steroid hormone receptor signaling pathway 1 Q96EB6 6 3.18e-02 90 2 1 0.500 0.011 GO:0010950 BP 1 positive regulation of endopeptidase activity 1 Q96EB6 6 3.21e-02 91 2 1 0.500 0.011 GO:0031668 BP 1 cellular response to extracellular stimulus 1 Q96EB6 6 3.22e-02 2283 2 2 1.000 0.001 TF:M04324_1 tf 1 Factor: GBX2; motif: NNYAATTANN; match class: 1 1 Q96EB6,Q8NAP3 6 3.26e-02 209 2 1 0.500 0.005 TF:M04201_0 tf 1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 0 1 Q8NAP3 6 3.28e-02 93 2 1 0.500 0.011 GO:2001242 BP 1 regulation of intrinsic apoptotic signaling pathway 1 Q96EB6 6 3.28e-02 93 2 1 0.500 0.011 GO:0009411 BP 1 response to UV 1 Q96EB6 6 3.28e-02 93 2 1 0.500 0.011 GO:0043401 BP 1 steroid hormone mediated signaling pathway 1 Q96EB6 6 3.30e-02 60 2 1 0.500 0.017 REAC:400253 rea 1 Circadian Clock 1 Q96EB6 6 3.32e-02 94 2 1 0.500 0.011 GO:0010952 BP 1 positive regulation of peptidase activity 1 Q96EB6 6 3.32e-02 94 2 1 0.500 0.011 GO:0014065 BP 1 phosphatidylinositol 3-kinase signaling 1 Q96EB6 6 3.32e-02 94 2 1 0.500 0.011 GO:0006479 BP 1 protein methylation 1 Q96EB6 6 3.32e-02 94 2 1 0.500 0.011 GO:0042306 BP 1 regulation of protein import into nucleus 1 Q96EB6 6 3.32e-02 94 2 1 0.500 0.011 GO:0008213 BP 1 protein alkylation 1 Q96EB6 6 3.33e-02 2 2 1 0.500 0.500 CORUM:2821 cor 1 hSIR2-p53 complex 1 Q96EB6 6 3.33e-02 2 2 1 0.500 0.500 CORUM:2593 cor 1 FOXO3-SIRT1 complex, oxidative stress stimulated 1 Q96EB6 6 3.35e-02 95 2 1 0.500 0.011 GO:0035257 MF 1 nuclear hormone receptor binding 1 Q96EB6 6 3.35e-02 95 2 1 0.500 0.011 GO:0002250 BP 1 adaptive immune response 1 Q96EB6 6 3.39e-02 96 2 1 0.500 0.010 GO:0071478 BP 1 cellular response to radiation 1 Q96EB6 6 3.39e-02 96 2 1 0.500 0.010 GO:1904589 BP 1 regulation of protein import 1 Q96EB6 6 3.42e-02 97 2 1 0.500 0.010 GO:1902275 BP 1 regulation of chromatin organization 1 Q96EB6 6 3.42e-02 97 2 1 0.500 0.010 GO:0007623 BP 1 circadian rhythm 1 Q96EB6 6 3.46e-02 98 2 1 0.500 0.010 GO:0000302 BP 1 response to reactive oxygen species 1 Q96EB6 6 3.47e-02 63 2 1 0.500 0.016 REAC:5250941 rea 1 Negative epigenetic regulation of rRNA expression 1 Q96EB6 6 3.49e-02 99 2 1 0.500 0.010 GO:0042770 BP 1 signal transduction in response to DNA damage 1 Q96EB6 6 3.49e-02 99 2 1 0.500 0.010 GO:0016241 BP 1 regulation of macroautophagy 1 Q96EB6 6 3.49e-02 99 2 1 0.500 0.010 GO:0016810 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Q96EB6 6 3.53e-02 100 2 1 0.500 0.010 GO:0015850 BP 1 organic hydroxy compound transport 1 Q96EB6 6 3.53e-02 100 2 1 0.500 0.010 GO:0072330 BP 1 monocarboxylic acid biosynthetic process 1 Q96EB6 6 3.53e-02 100 2 1 0.500 0.010 GO:0009408 BP 1 response to heat 1 Q96EB6 6 3.53e-02 100 2 1 0.500 0.010 GO:0030308 BP 1 negative regulation of cell growth 1 Q96EB6 6 3.60e-02 102 2 1 0.500 0.010 GO:1901617 BP 1 organic hydroxy compound biosynthetic process 1 Q96EB6 6 3.63e-02 103 2 1 0.500 0.010 GO:0016573 BP 1 histone acetylation 1 Q96EB6 6 3.70e-02 105 2 1 0.500 0.010 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q96EB6 6 3.70e-02 105 2 1 0.500 0.010 GO:0051427 MF 1 hormone receptor binding 1 Q96EB6 6 3.70e-02 105 2 1 0.500 0.010 GO:0045765 BP 1 regulation of angiogenesis 1 Q96EB6 6 3.70e-02 238 2 1 0.500 0.004 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 Q8NAP3 6 3.74e-02 2461 2 2 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q96EB6,Q8NAP3 6 3.75e-02 83 2 1 0.500 0.012 KEGG:04211 keg 1 Longevity regulating pathway 1 Q96EB6 6 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q8NAP3 6 3.77e-02 242 2 1 0.500 0.004 TF:M05961_1 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 1 1 Q96EB6 6 3.77e-02 107 2 1 0.500 0.009 GO:0006289 BP 1 nucleotide-excision repair 1 Q96EB6 6 3.77e-02 107 2 1 0.500 0.009 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0010565 BP 1 regulation of cellular ketone metabolic process 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0008022 MF 1 protein C-terminus binding 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0031667 BP 1 response to nutrient levels 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0007179 BP 1 transforming growth factor beta receptor signaling pathway 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0071383 BP 1 cellular response to steroid hormone stimulus 1 Q96EB6 6 3.81e-02 108 2 1 0.500 0.009 GO:0009755 BP 1 hormone-mediated signaling pathway 1 Q96EB6 6 3.84e-02 109 2 1 0.500 0.009 GO:0032869 BP 1 cellular response to insulin stimulus 1 Q96EB6 6 3.84e-02 247 2 1 0.500 0.004 TF:M01029_1 tf 1 Factor: TFE; motif: TCATGTGN; match class: 1 1 Q8NAP3 6 3.88e-02 110 2 1 0.500 0.009 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q96EB6 6 3.88e-02 110 2 1 0.500 0.009 GO:0006006 BP 1 glucose metabolic process 1 Q96EB6 6 3.89e-02 2511 2 2 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q96EB6,Q8NAP3 6 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 Q96EB6,Q8NAP3 6 3.91e-02 111 2 1 0.500 0.009 GO:0090092 BP 1 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q96EB6 6 3.98e-02 113 2 1 0.500 0.009 GO:0050678 BP 1 regulation of epithelial cell proliferation 1 Q96EB6 6 4.02e-02 89 2 1 0.500 0.011 KEGG:04922 keg 1 Glucagon signaling pathway 1 Q96EB6 6 4.02e-02 114 2 1 0.500 0.009 GO:0032868 BP 1 response to insulin 1 Q96EB6 6 4.04e-02 260 2 1 0.500 0.004 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 Q8NAP3 6 4.05e-02 115 2 1 0.500 0.009 GO:0001666 BP 1 response to hypoxia 1 Q96EB6 6 4.05e-02 115 2 1 0.500 0.009 GO:0090287 BP 1 regulation of cellular response to growth factor stimulus 1 Q96EB6 6 4.09e-02 263 2 1 0.500 0.004 TF:M06419_0 tf 1 Factor: ZNF493; motif: NGKTAYKGGMGA; match class: 0 1 Q96EB6 6 4.10e-02 1635 2 2 1.000 0.001 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q96EB6,Q8NAP3 6 4.13e-02 75 2 1 0.500 0.013 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 Q96EB6 6 4.14e-02 266 2 1 0.500 0.004 TF:M04196_1 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 1 1 Q96EB6 6 4.14e-02 266 2 1 0.500 0.004 TF:M04196_0 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 0 1 Q96EB6 6 4.15e-02 1644 2 2 1.000 0.001 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q96EB6,Q8NAP3 6 4.16e-02 118 2 1 0.500 0.008 GO:0048511 BP 1 rhythmic process 1 Q96EB6 6 4.16e-02 118 2 1 0.500 0.008 GO:0036293 BP 1 response to decreased oxygen levels 1 Q96EB6 6 4.16e-02 118 2 1 0.500 0.008 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:0071496 BP 1 cellular response to external stimulus 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:0009991 BP 1 response to extracellular stimulus 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:0048017 BP 1 inositol lipid-mediated signaling 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:2001020 BP 1 regulation of response to DNA damage stimulus 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:0009266 BP 1 response to temperature stimulus 1 Q96EB6 6 4.19e-02 119 2 1 0.500 0.008 GO:1900180 BP 1 regulation of protein localization to nucleus 1 Q96EB6 6 4.21e-02 1656 2 2 1.000 0.001 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q96EB6,Q8NAP3 6 4.23e-02 120 2 1 0.500 0.008 GO:1901342 BP 1 regulation of vasculature development 1 Q96EB6 6 4.23e-02 120 2 1 0.500 0.008 GO:2001234 BP 1 negative regulation of apoptotic signaling pathway 1 Q96EB6 6 4.24e-02 2622 2 2 1.000 0.001 TF:M04072_0 tf 1 Factor: POU2F2; motif: NTATGCWAATN; match class: 0 1 Q96EB6,Q8NAP3 6 4.24e-02 1663 2 2 1.000 0.001 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q96EB6,Q8NAP3 6 4.25e-02 2624 2 2 1.000 0.001 TF:M04088_0 tf 1 Factor: POU5F1B; motif: TATGCWAAT; match class: 0 1 Q96EB6,Q8NAP3 6 4.26e-02 121 2 1 0.500 0.008 GO:0043281 BP 1 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 Q96EB6 6 4.30e-02 122 2 1 0.500 0.008 GO:0034599 BP 1 cellular response to oxidative stress 1 Q96EB6 6 4.30e-02 122 2 1 0.500 0.008 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 Q96EB6 6 4.30e-02 122 2 1 0.500 0.008 GO:0045926 BP 1 negative regulation of growth 1 Q96EB6 6 4.30e-02 122 2 1 0.500 0.008 GO:0070482 BP 1 response to oxygen levels 1 Q96EB6 6 4.34e-02 1681 2 2 1.000 0.001 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q96EB6,Q8NAP3 6 4.44e-02 126 2 1 0.500 0.008 GO:0044262 BP 1 cellular carbohydrate metabolic process 1 Q96EB6 6 4.47e-02 127 2 1 0.500 0.008 GO:0006473 BP 1 protein acetylation 1 Q96EB6 6 4.47e-02 127 2 1 0.500 0.008 GO:0048545 BP 1 response to steroid hormone 1 Q96EB6 6 4.51e-02 128 2 1 0.500 0.008 GO:0071560 BP 1 cellular response to transforming growth factor beta stimulus 1 Q96EB6 6 4.51e-02 128 2 1 0.500 0.008 GO:0051054 BP 1 positive regulation of DNA metabolic process 1 Q96EB6 6 4.54e-02 129 2 1 0.500 0.008 GO:0042393 MF 1 histone binding 1 Q96EB6 6 4.54e-02 129 2 1 0.500 0.008 GO:0071559 BP 1 response to transforming growth factor beta 1 Q96EB6 6 4.65e-02 132 2 1 0.500 0.008 GO:0030099 BP 1 myeloid cell differentiation 1 Q96EB6 6 4.67e-02 1745 2 2 1.000 0.001 GO:0009893 BP 1 positive regulation of metabolic process 1 Q96EB6,Q8NAP3 6 4.68e-02 133 2 1 0.500 0.008 GO:0050673 BP 1 epithelial cell proliferation 1 Q96EB6 6 4.68e-02 133 2 1 0.500 0.008 GO:0006469 BP 1 negative regulation of protein kinase activity 1 Q96EB6 6 4.79e-02 136 2 1 0.500 0.007 GO:0071356 BP 1 cellular response to tumor necrosis factor 1 Q96EB6 6 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q96EB6,Q8NAP3 6 4.82e-02 107 2 1 0.500 0.009 KEGG:04152 keg 1 AMPK signaling pathway 1 Q96EB6 6 4.82e-02 137 2 1 0.500 0.007 GO:0019318 BP 1 hexose metabolic process 1 Q96EB6 6 4.84e-02 1775 2 2 1.000 0.001 GO:0051252 BP 1 regulation of RNA metabolic process 1 Q96EB6,Q8NAP3 6 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 Q96EB6 6 4.90e-02 139 2 1 0.500 0.007 GO:1901796 BP 1 regulation of signal transduction by p53 class mediator 1 Q96EB6 6 4.90e-02 139 2 1 0.500 0.007 GO:2000116 BP 1 regulation of cysteine-type endopeptidase activity 1 Q96EB6 6 4.93e-02 140 2 1 0.500 0.007 GO:0071897 BP 1 DNA biosynthetic process 1 Q96EB6 6 4.93e-02 140 2 1 0.500 0.007 GO:0008202 BP 1 steroid metabolic process 1 Q96EB6 6 4.95e-02 319 2 1 0.500 0.003 TF:M01830_0 tf 1 Factor: MAX; motif: CNNGMCACGTGN; match class: 0 1 Q96EB6 6 4.97e-02 2837 2 2 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 Q96EB6,Q8NAP3 6 4.97e-02 2837 2 2 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 Q96EB6,Q8NAP3 6 5.00e-02 142 2 1 0.500 0.007 GO:0042180 BP 1 cellular ketone metabolic process 1 Q96EB6 6 5.00e-02 3 2 1 0.500 0.333 CORUM:2590 cor 1 FOXO1-FHL2-SIRT1 complex 1 Q96EB6 6 5.00e-02 3 2 1 0.500 0.333 CORUM:1177 cor 1 Polycomb repressive complex 4 (PRC4) 1 Q96EB6 6 5.00e-02 111 2 1 0.500 0.009 KEGG:04068 keg 1 FoxO signaling pathway 1 Q96EB6 7 8.72e-03 872 6 3 0.500 0.003 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 A6ZKI3,Q9BWD3,Q17RB0 7 2.33e-02 24 6 1 0.167 0.042 REAC:4085001 rea 1 Sialic acid metabolism 1 Q9BXD5 7 3.09e-02 1380 6 3 0.500 0.002 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 A6ZKI3,Q9BWD3,Q17RB0 7 3.12e-02 408 6 2 0.333 0.005 MI:mmu-miR-677 mi 1 MI:mmu-miR-677 1 A6ZKI3,Q9BXD5 7 3.47e-02 432 6 2 0.333 0.005 MI:hsa-miR-887 mi 1 MI:hsa-miR-887 1 A6ZKI3,O95751 7 3.96e-02 463 6 2 0.333 0.004 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 Q9BXD5,O95751 7 4.07e-02 470 6 2 0.333 0.004 MI:hsa-miR-18a mi 1 MI:hsa-miR-18a 1 A6ZKI3,Q9BXD5 7 4.16e-02 475 6 2 0.333 0.004 MI:hsa-miR-196b mi 1 MI:hsa-miR-196b 1 A6ZKI3,O95751 7 4.16e-02 1042 6 4 0.667 0.004 TF:M00672_0 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 0 1 A6ZKI3,Q9BXD5,Q9BWD3,Q17RB0 7 4.21e-02 1550 6 3 0.500 0.002 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 A6ZKI3,Q9BWD3,Q17RB0 7 4.60e-02 501 6 2 0.333 0.004 MI:hsa-miR-196a mi 1 MI:hsa-miR-196a 1 A6ZKI3,O95751 7 4.98e-02 523 6 2 0.333 0.004 MI:hsa-miR-582-3p mi 1 MI:hsa-miR-582-3p 1 A6ZKI3,Q9BXD5 7 5.00e-02 1 6 1 0.167 1.000 GO:0008747 MF 1 N-acetylneuraminate lyase activity 1 Q9BXD5 7 5.00e-02 52 6 1 0.167 0.019 REAC:446219 rea 1 Synthesis of substrates in N-glycan biosythesis 1 Q9BXD5 7 5.00e-02 1093 6 4 0.667 0.004 TF:M07064_1 tf 1 Factor: STAT1; motif: TTCNRGGAAN; match class: 1 1 A6ZKI3,O95751,Q17RB0,Q86TG7 8 2.36e-03 15 2 1 0.500 0.067 TF:M06743_0 tf 1 Factor: ZNF287; motif: NTGTTAAGACGM; match class: 0 1 Q15696 8 2.53e-03 564 2 2 1.000 0.004 MI:hsa-miR-518e mi 1 MI:hsa-miR-518e 1 Q96F63,Q15696 8 3.86e-03 791 2 2 1.000 0.003 TF:M01259_0 tf 1 Factor: CTCF; motif: NNNNNNCCASNAGRKGGCRS; match class: 0 1 Q96F63,Q15696 8 5.18e-03 33 2 1 0.500 0.030 TF:M06597_1 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 1 1 Q96F63 8 5.81e-03 37 2 1 0.500 0.027 TF:M06762_0 tf 1 Factor: ZNF222; motif: NGGTCRAAACGA; match class: 0 1 Q96F63 8 8.00e-03 51 2 1 0.500 0.020 TF:M06454_0 tf 1 Factor: ZNF786; motif: KGGWTYAGGGGA; match class: 0 1 Q15696 8 8.34e-03 4 2 1 0.500 0.250 GO:0089701 CC 1 U2AF 1 Q15696 8 8.69e-03 1187 2 2 1.000 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 Q96F63,Q15696 8 9.17e-03 1219 2 2 1.000 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q96F63,Q15696 8 1.00e-02 64 2 1 0.500 0.016 TF:M05826_0 tf 1 Factor: ZNF66; motif: GTSTTCAACTWA; match class: 0 1 Q15696 8 1.04e-02 5 2 1 0.500 0.200 GO:0030628 MF 1 pre-mRNA 3'-splice site binding 1 Q15696 8 1.32e-02 84 2 1 0.500 0.012 TF:M05865_0 tf 1 Factor: ZNF709; motif: NGYTCCAACACC; match class: 0 1 Q96F63 8 1.39e-02 89 2 1 0.500 0.011 TF:M00778_0 tf 1 Factor: AhR; motif: NTNGCGTGNNN; match class: 0 1 Q96F63 8 1.46e-02 93 2 1 0.500 0.011 TF:M00260_1 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 1 1 Q15696 8 1.78e-02 114 2 1 0.500 0.009 TF:M01774_1 tf 1 Factor: TBR2; motif: AGGTGTGAA; match class: 1 1 Q96F63 8 1.92e-02 1765 2 2 1.000 0.001 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q96F63,Q15696 8 2.36e-02 151 2 1 0.500 0.007 TF:M04619_1 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 1 Q96F63 8 2.48e-02 159 2 1 0.500 0.006 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 Q96F63 8 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q15696 8 2.98e-02 191 2 1 0.500 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 Q96F63 8 3.23e-02 1941 2 2 1.000 0.001 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q96F63,Q15696 8 3.24e-02 599 2 2 1.000 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q96F63,Q15696 8 3.25e-02 600 2 2 1.000 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 Q96F63,Q15696 8 3.47e-02 2372 2 2 1.000 0.001 TF:M04627_0 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 0 1 Q96F63,Q15696 8 3.75e-02 18 2 1 0.500 0.056 GO:0036002 MF 1 pre-mRNA binding 1 Q15696 8 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 Q96F63 8 3.78e-02 243 2 1 0.500 0.004 TF:M00641_0 tf 1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 0 1 Q96F63 8 3.96e-02 19 2 1 0.500 0.053 GO:0005686 CC 1 U2 snRNP 1 Q96F63 8 4.23e-02 2617 2 2 1.000 0.001 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 Q96F63,Q15696 8 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 Q15696 8 4.52e-02 291 2 1 0.500 0.003 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 Q15696 8 4.55e-02 2716 2 2 1.000 0.001 TF:M03562_0 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 0 1 Q96F63,Q15696 8 4.64e-02 2743 2 2 1.000 0.001 TF:M04084_0 tf 1 Factor: POU3F4; motif: TGCATAAWTTA; match class: 0 1 Q96F63,Q15696 8 4.67e-02 301 2 1 0.500 0.003 TF:M04134_1 tf 1 Factor: TBX2; motif: NAGGTGTGAAN; match class: 1 1 Q96F63 8 4.78e-02 308 2 1 0.500 0.003 TF:M07305_1 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 1 1 Q15696 8 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q96F63,Q15696 8 4.80e-02 309 2 1 0.500 0.003 TF:M05390_0 tf 1 Factor: TBPL2; motif: CTTTTAAATC; match class: 0 1 Q15696 8 5.00e-02 23 2 1 0.500 0.043 CORUM:430 cor 1 18S U11/U12 snRNP 1 Q15696 8 5.00e-02 51 2 1 0.500 0.020 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q15696 8 5.00e-02 24 2 1 0.500 0.042 GO:0005689 CC 1 U12-type spliceosomal complex 1 Q15696 9 1.69e-07 20 4 3 0.750 0.150 REAC:212676 rea 1 Dopamine Neurotransmitter Release Cycle 1 Q9HAP6,O14936,Q9NUP9 9 9.69e-07 35 4 3 0.750 0.086 REAC:112310 rea 1 Neurotransmitter Release Cycle 1 Q9HAP6,O14936,Q9NUP9 9 1.92e-06 320 4 4 1.000 0.013 GO:0098590 CC 1 plasma membrane region 1 Q9HAP6,O75970,O14936,Q9NUP9 9 2.97e-06 5 4 2 0.500 0.400 GO:1903361 BP 1 protein localization to basolateral plasma membrane 1 Q9HAP6,Q9NUP9 9 3.90e-06 78 4 3 0.750 0.038 GO:0007269 BP 1 neurotransmitter secretion 1 Q9HAP6,O14936,Q9NUP9 9 3.90e-06 78 4 3 0.750 0.038 GO:0099643 BP 1 signal release from synapse 1 Q9HAP6,O14936,Q9NUP9 9 5.43e-06 87 4 3 0.750 0.034 GO:0099531 BP 1 presynaptic process involved in chemical synaptic transmission 1 Q9HAP6,O14936,Q9NUP9 9 6.24e-06 7 4 2 0.500 0.286 GO:0045199 BP 1 maintenance of epithelial cell apical/basal polarity 1 Q9HAP6,Q9NUP9 9 6.24e-06 7 4 2 0.500 0.286 GO:0035090 BP 1 maintenance of apical/basal cell polarity 1 Q9HAP6,Q9NUP9 9 8.28e-06 100 4 3 0.750 0.030 GO:0006836 BP 1 neurotransmitter transport 1 Q9HAP6,O14936,Q9NUP9 9 1.07e-05 109 4 3 0.750 0.028 GO:0001505 BP 1 regulation of neurotransmitter levels 1 Q9HAP6,O14936,Q9NUP9 9 1.34e-05 10 4 2 0.500 0.200 GO:0030011 BP 1 maintenance of cell polarity 1 Q9HAP6,Q9NUP9 9 2.46e-05 3 4 2 0.500 0.667 CORUM:617 cor 1 CASK-LIN7C-APBA1 complex 1 O14936,Q9NUP9 9 5.20e-05 184 4 3 0.750 0.016 GO:0023061 BP 1 signal release 1 Q9HAP6,O14936,Q9NUP9 9 5.64e-05 20 4 2 0.500 0.100 GO:0045197 BP 1 establishment or maintenance of epithelial cell apical/basal polarity 1 Q9HAP6,Q9NUP9 9 7.50e-05 23 4 2 0.500 0.087 GO:0035088 BP 1 establishment or maintenance of apical/basal cell polarity 1 Q9HAP6,Q9NUP9 9 7.50e-05 23 4 2 0.500 0.087 GO:0061245 BP 1 establishment or maintenance of bipolar cell polarity 1 Q9HAP6,Q9NUP9 9 1.05e-04 164 4 3 0.750 0.018 REAC:112315 rea 1 Transmission across Chemical Synapses 1 Q9HAP6,O14936,Q9NUP9 9 1.62e-04 269 4 3 0.750 0.011 GO:0099536 BP 1 synaptic signaling 1 Q9HAP6,O14936,Q9NUP9 9 1.62e-04 269 4 3 0.750 0.011 GO:0098916 BP 1 anterograde trans-synaptic signaling 1 Q9HAP6,O14936,Q9NUP9 9 1.62e-04 269 4 3 0.750 0.011 GO:0007268 BP 1 chemical synaptic transmission 1 Q9HAP6,O14936,Q9NUP9 9 1.62e-04 269 4 3 0.750 0.011 GO:0099537 BP 1 trans-synaptic signaling 1 Q9HAP6,O14936,Q9NUP9 9 3.81e-04 252 4 3 0.750 0.012 REAC:112316 rea 1 Neuronal System 1 Q9HAP6,O14936,Q9NUP9 9 4.85e-04 1272 4 4 1.000 0.003 GO:0044459 CC 1 plasma membrane part 1 Q9HAP6,O75970,O14936,Q9NUP9 9 6.15e-04 420 4 3 0.750 0.007 GO:0005911 CC 1 cell-cell junction 1 Q9HAP6,O14936,Q9NUP9 9 8.18e-04 75 4 2 0.500 0.027 GO:0016323 CC 1 basolateral plasma membrane 1 Q9HAP6,Q9NUP9 9 8.27e-04 464 4 3 0.750 0.006 GO:0032940 BP 1 secretion by cell 1 Q9HAP6,O14936,Q9NUP9 9 9.79e-04 491 4 3 0.750 0.006 GO:0046903 BP 1 secretion 1 Q9HAP6,O14936,Q9NUP9 9 1.51e-03 102 4 2 0.500 0.020 GO:0007163 BP 1 establishment or maintenance of cell polarity 1 Q9HAP6,Q9NUP9 9 3.25e-03 64 4 2 0.500 0.031 HP:0009879 hp 1 Cortical gyral simplification 1 O75970,O14936 9 3.35e-03 152 4 2 0.500 0.013 GO:1990778 BP 1 protein localization to cell periphery 1 Q9HAP6,Q9NUP9 9 3.38e-03 746 4 3 0.750 0.004 GO:0030054 CC 1 cell junction 1 Q9HAP6,O14936,Q9NUP9 9 3.43e-03 3 4 1 0.250 0.333 GO:0097025 CC 1 MPP7-DLG1-LIN7 complex 1 Q9NUP9 9 3.43e-03 3 4 1 0.250 0.333 GO:0097016 MF 1 L27 domain binding 1 Q9NUP9 9 3.49e-03 754 4 3 0.750 0.004 GO:0007267 BP 1 cell-cell signaling 1 Q9HAP6,O14936,Q9NUP9 9 4.46e-03 3 4 1 0.250 0.333 HP:0000300 hp 1 Oval face 1 O14936 9 4.57e-03 4 4 1 0.250 0.250 GO:0016327 CC 1 apicolateral plasma membrane 1 O75970 9 4.57e-03 4 4 1 0.250 0.250 GO:0005652 CC 1 nuclear lamina 1 O14936 9 5.71e-03 5 4 1 0.250 0.200 GO:0010839 BP 1 negative regulation of keratinocyte proliferation 1 O14936 9 6.29e-03 2412 4 4 1.000 0.002 GO:0044425 CC 1 membrane part 1 Q9HAP6,O75970,O14936,Q9NUP9 9 6.37e-03 2420 4 4 1.000 0.002 GO:0005886 CC 1 plasma membrane 1 Q9HAP6,O75970,O14936,Q9NUP9 9 6.90e-03 2469 4 4 1.000 0.002 GO:0071944 CC 1 cell periphery 1 Q9HAP6,O75970,O14936,Q9NUP9 9 8.57e-03 244 4 2 0.500 0.008 GO:0006887 BP 1 exocytosis 1 Q9HAP6,Q9NUP9 9 1.03e-02 8 4 1 0.250 0.125 REAC:5666185 rea 1 RHO GTPases Activate Rhotekin and Rhophilins 1 Q9HAP6 9 1.25e-02 2 4 1 0.250 0.500 CORUM:3208 cor 1 LIN2-LIN7 complex 1 O14936 9 1.26e-02 11 4 1 0.250 0.091 GO:0004385 MF 1 guanylate kinase activity 1 O14936 9 1.27e-02 298 4 2 0.500 0.007 GO:0019904 MF 1 protein domain specific binding 1 Q9HAP6,Q9NUP9 9 1.63e-02 11 4 1 0.250 0.091 HP:0007227 hp 1 Macrogyria 1 O14936 9 1.67e-02 1 4 1 0.250 1.000 OMIM:300422 omi 1 FG SYNDROME 4; FGS4MENTAL RETARDATION, X-LINKED, WITH OR WITHOUT NYSTAGMUS, INCLUDED 1 O14936 9 1.67e-02 1 4 1 0.250 1.000 OMIM:615219 omi 1 HYDROCEPHALUS, NONSYNDROMIC, AUTOSOMAL RECESSIVE 2; HYC2 1 O75970 9 1.67e-02 1 4 1 0.250 1.000 OMIM:300749 omi 1 MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLAR HYPOPLASIA;MICPCH;;MICPCH SYNDROME;;MENTAL RETARDATION, X-LINKED, SYNDROMIC, NAJM TYPE; MRXSNA 1 O14936 9 1.71e-02 288 4 2 0.500 0.007 MI:hsa-miR-424* mi 1 MI:hsa-miR-424* 1 O75970,O14936 9 1.82e-02 16 4 1 0.250 0.062 GO:0010837 BP 1 regulation of keratinocyte proliferation 1 O14936 9 1.93e-02 369 4 2 0.500 0.005 GO:0072657 BP 1 protein localization to membrane 1 Q9HAP6,Q9NUP9 9 2.19e-02 170 4 2 0.500 0.012 HP:0002536 hp 1 Abnormal cortical gyration 1 O75970,O14936 9 2.28e-02 20 4 1 0.250 0.050 GO:0001953 BP 1 negative regulation of cell-matrix adhesion 1 O14936 9 2.32e-02 18 4 1 0.250 0.056 REAC:3000170 rea 1 Syndecan interactions 1 O14936 9 2.51e-02 4 4 1 0.250 0.250 CORUM:3207 cor 1 LIN2-LIN7-SAP97-MINT1 complex 1 O14936 9 2.51e-02 22 4 1 0.250 0.045 GO:0019201 MF 1 nucleotide kinase activity 1 O14936 9 2.51e-02 22 4 1 0.250 0.045 GO:0043616 BP 1 keratinocyte proliferation 1 O14936 9 2.58e-02 1493 4 3 0.750 0.002 GO:0051649 BP 1 establishment of localization in cell 1 Q9HAP6,O14936,Q9NUP9 9 2.60e-02 1498 4 3 0.750 0.002 GO:0044765 BP 1 single-organism transport 1 Q9HAP6,O14936,Q9NUP9 9 2.62e-02 23 4 1 0.250 0.043 GO:0042734 CC 1 presynaptic membrane 1 O14936 9 2.63e-02 187 4 2 0.500 0.011 HP:0002538 hp 1 Abnormality of the cerebral cortex 1 O75970,O14936 9 2.69e-02 363 4 2 0.500 0.006 MI:mmu-miR-295 mi 1 MI:mmu-miR-295 1 Q9HAP6,O14936 9 2.76e-02 368 4 2 0.500 0.005 MI:hsa-miR-372 mi 1 MI:hsa-miR-372 1 Q9HAP6,O14936 9 2.80e-02 19 4 1 0.250 0.053 HP:0010851 hp 1 EEG with burst suppression 1 O14936 9 2.83e-02 22 4 1 0.250 0.045 REAC:373753 rea 1 Nephrin interactions 1 O14936 9 3.03e-02 386 4 2 0.500 0.005 MI:hsa-miR-765 mi 1 MI:hsa-miR-765 1 Q9HAP6,O75970 9 3.09e-02 21 4 1 0.250 0.048 HP:0010818 hp 1 Generalized tonic seizures 1 O14936 9 3.30e-02 29 4 1 0.250 0.034 GO:0060170 CC 1 ciliary membrane 1 O14936 9 3.35e-02 406 4 2 0.500 0.005 MI:hsa-miR-544 mi 1 MI:hsa-miR-544 1 O75970,O14936 9 3.38e-02 23 4 1 0.250 0.043 HP:0007105 hp 1 Infantile encephalopathy 1 O14936 9 3.42e-02 30 4 1 0.250 0.033 GO:0002011 BP 1 morphogenesis of an epithelial sheet 1 Q9NUP9 9 3.45e-02 1652 4 3 0.750 0.002 GO:1902578 BP 1 single-organism localization 1 Q9HAP6,O14936,Q9NUP9 9 3.53e-02 31 4 1 0.250 0.032 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 O14936 9 3.63e-02 2392 4 3 0.750 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q9HAP6,O75970,Q9NUP9 9 3.68e-02 426 4 2 0.500 0.005 MI:hsa-miR-576-5p mi 1 MI:hsa-miR-576-5p 1 O75970,O14936 9 3.82e-02 26 4 1 0.250 0.038 HP:0001151 hp 1 Impaired horizontal smooth pursuit 1 O14936 9 3.90e-02 439 4 2 0.500 0.005 MI:hsa-miR-363 mi 1 MI:hsa-miR-363 1 O75970,O14936 9 3.98e-02 35 4 1 0.250 0.029 GO:0005604 CC 1 basement membrane 1 O14936 9 4.04e-02 447 4 2 0.500 0.004 MI:hsa-miR-216b mi 1 MI:hsa-miR-216b 1 O75970,O14936 9 4.10e-02 36 4 1 0.250 0.028 GO:0016776 MF 1 phosphotransferase activity, phosphate group as acceptor 1 O14936 9 4.21e-02 37 4 1 0.250 0.027 GO:0061045 BP 1 negative regulation of wound healing 1 O14936 9 4.22e-02 240 4 2 0.500 0.008 HP:0002269 hp 1 Abnormality of neuronal migration 1 O75970,O14936 9 4.23e-02 2527 4 3 0.750 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 Q9HAP6,O75970,Q9NUP9 9 4.39e-02 30 4 1 0.250 0.033 HP:0012469 hp 1 Infantile spasms 1 O14936 9 4.43e-02 4954 4 4 1.000 0.001 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 Q9HAP6,O75970,O14936,Q9NUP9 9 4.45e-02 470 4 2 0.500 0.004 MI:hsa-miR-195 mi 1 MI:hsa-miR-195 1 O75970,O14936 9 4.66e-02 41 4 1 0.250 0.024 GO:1903035 BP 1 negative regulation of response to wounding 1 O14936 9 4.68e-02 1836 4 3 0.750 0.002 GO:0051641 BP 1 cellular localization 1 Q9HAP6,O14936,Q9NUP9 9 4.69e-02 582 4 2 0.500 0.003 GO:0005912 CC 1 adherens junction 1 O14936,Q9NUP9 9 4.75e-02 5041 4 4 1.000 0.001 HPA:020010_01 hpa 1 lateral ventricle; glial cells[Uncertain,Low] 1 Q9HAP6,O75970,O14936,Q9NUP9 9 4.83e-02 33 4 1 0.250 0.030 HP:0011097 hp 1 Epileptic spasms 1 O14936 9 4.83e-02 33 4 1 0.250 0.030 HP:0006808 hp 1 Cerebral hypomyelination 1 O14936 9 4.84e-02 591 4 2 0.500 0.003 GO:0070161 CC 1 anchoring junction 1 O14936,Q9NUP9 9 4.85e-02 491 4 2 0.500 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 Q9HAP6,O14936 9 5.00e-02 111 4 2 0.500 0.018 KEGG:04530 keg 1 Tight junction 1 O75970,O14936 9 5.00e-02 3 4 1 0.250 0.333 OMIM:236600 omi 1 Congenital Hydrocephalus 1 O75970 9 5.00e-02 8 4 1 0.250 0.125 CORUM:848 cor 1 RICH1/AMOT polarity complex, Flag-Amot precipitated 1 O75970 9 5.00e-02 499 4 2 0.500 0.004 MI:hsa-miR-582-5p mi 1 MI:hsa-miR-582-5p 1 O75970,O14936 9 5.00e-02 521 4 3 0.750 0.006 TF:M07205_0 tf 1 Factor: CEBPA; motif: ATTGCAYAAYN; match class: 0 1 Q9HAP6,O75970,O14936 9 5.00e-02 44 4 1 0.250 0.023 GO:0019205 MF 1 nucleobase-containing compound kinase activity 1 O14936 9 5.00e-02 3 4 1 0.250 0.333 OMIM:305450 omi 1 FG Syndrome 1 O14936 9 5.00e-02 39 4 1 0.250 0.026 REAC:3000171 rea 1 Non-integrin membrane-ECM interactions 1 O14936 10 1.12e-02 416 4 2 0.500 0.005 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 O75071,Q6P4E1 10 1.25e-02 1492 4 3 0.750 0.002 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 1.53e-02 1600 4 3 0.750 0.002 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 1.60e-02 1622 4 3 0.750 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 1.60e-02 1622 4 3 0.750 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 1.60e-02 1623 4 3 0.750 0.002 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 1.85e-02 1707 4 3 0.750 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 1.96e-02 555 4 2 0.500 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 O75071,Q6P4E1 10 2.08e-02 1780 4 3 0.750 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.14e-02 1797 4 3 0.750 0.002 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 2.22e-02 1820 4 3 0.750 0.002 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 2.43e-02 1880 4 3 0.750 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.45e-02 1885 4 3 0.750 0.002 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.46e-02 624 4 2 0.500 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 O75071,Q6P4E1 10 2.52e-02 1904 4 3 0.750 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.54e-02 1909 4 3 0.750 0.002 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.63e-02 1932 4 3 0.750 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.64e-02 1933 4 3 0.750 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.68e-02 653 4 2 0.500 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 O75071,Q6P4E1 10 2.70e-02 1950 4 3 0.750 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 2.80e-02 1974 4 3 0.750 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.85e-02 1986 4 3 0.750 0.002 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.86e-02 1989 4 3 0.750 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 2.90e-02 1998 4 3 0.750 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.00e-02 2024 4 3 0.750 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.01e-02 2026 4 3 0.750 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.07e-02 2039 4 3 0.750 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.08e-02 2043 4 3 0.750 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.12e-02 2051 4 3 0.750 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.16e-02 2060 4 3 0.750 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.21e-02 2071 4 3 0.750 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.21e-02 2072 4 3 0.750 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 Q96HH9,O75071,Q6P4E1 10 3.30e-02 2092 4 3 0.750 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.38e-02 2110 4 3 0.750 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.42e-02 2119 4 3 0.750 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.51e-02 2139 4 3 0.750 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.55e-02 2146 4 3 0.750 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 Q3KR37,O75071,Q6P4E1 10 3.57e-02 2151 4 3 0.750 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.58e-02 2154 4 3 0.750 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.61e-02 2159 4 3 0.750 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.65e-02 2168 4 3 0.750 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.69e-02 2176 4 3 0.750 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.72e-02 775 4 2 0.500 0.003 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 O75071,Q6P4E1 10 3.72e-02 2183 4 3 0.750 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.74e-02 2188 4 3 0.750 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.79e-02 2197 4 3 0.750 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.81e-02 2202 4 3 0.750 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.82e-02 4447 4 4 1.000 0.001 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 Q3KR37,Q96HH9,O75071,Q6P4E1 10 3.85e-02 2209 4 3 0.750 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.88e-02 2215 4 3 0.750 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 3.93e-02 798 4 2 0.500 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 O75071,Q6P4E1 10 3.94e-02 2227 4 3 0.750 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.94e-02 2227 4 3 0.750 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q96HH9,O75071,Q6P4E1 10 3.95e-02 4485 4 4 1.000 0.001 HPA:011010_01 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Low] 1 Q3KR37,Q96HH9,O75071,Q6P4E1 10 4.15e-02 2270 4 3 0.750 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.16e-02 2271 4 3 0.750 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.17e-02 2274 4 3 0.750 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.18e-02 2276 4 3 0.750 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.20e-02 2279 4 3 0.750 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.21e-02 2281 4 3 0.750 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.24e-02 2286 4 3 0.750 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.26e-02 2290 4 3 0.750 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.29e-02 836 4 2 0.500 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 O75071,Q6P4E1 10 4.35e-02 2308 4 3 0.750 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.36e-02 2310 4 3 0.750 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.46e-02 2328 4 3 0.750 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.54e-02 2342 4 3 0.750 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.60e-02 867 4 2 0.500 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 O75071,Q6P4E1 10 4.67e-02 2366 4 3 0.750 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.67e-02 874 4 2 0.500 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q96HH9,Q6P4E1 10 4.77e-02 2385 4 3 0.750 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.83e-02 2395 4 3 0.750 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.84e-02 2397 4 3 0.750 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 4.95e-02 2417 4 3 0.750 0.001 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 5.00e-02 906 4 2 0.500 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 O75071,Q6P4E1 10 5.00e-02 2425 4 3 0.750 0.001 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q96HH9,O75071,Q6P4E1 10 5.00e-02 35 4 1 0.250 0.029 GO:0005881 CC 1 cytoplasmic microtubule 1 Q96HH9 10 5.00e-02 1557 4 4 1.000 0.003 TF:M07044_1 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 1 Q3KR37,Q96HH9,O75071,Q6P4E1 10 5.00e-02 435 4 2 0.500 0.005 MI:hsa-miR-32 mi 1 MI:hsa-miR-32 1 Q3KR37,Q96HH9 11 1.27e-04 68 2 2 1.000 0.029 GO:0060205 CC 1 cytoplasmic vesicle lumen 1 P04114,O43707 11 1.31e-04 69 2 2 1.000 0.029 GO:0031983 CC 1 vesicle lumen 1 P04114,O43707 11 6.43e-04 1 2 1 0.500 1.000 GO:0034360 CC 1 chylomicron remnant 1 P04114 11 6.43e-04 1 2 1 0.500 1.000 GO:0034359 CC 1 mature chylomicron 1 P04114 11 1.20e-03 3 2 1 0.500 0.333 REAC:3000497 rea 1 Scavenging by Class H Receptors 1 P04114 11 1.20e-03 3 2 1 0.500 0.333 REAC:3000471 rea 1 Scavenging by Class B Receptors 1 P04114 11 1.29e-03 2 2 1 0.500 0.500 GO:0032417 BP 1 positive regulation of sodium:proton antiporter activity 1 O43707 11 1.29e-03 2 2 1 0.500 0.500 GO:0035473 MF 1 lipase binding 1 P04114 11 1.93e-03 3 2 1 0.500 0.333 GO:0032415 BP 1 regulation of sodium:proton antiporter activity 1 O43707 11 1.93e-03 3 2 1 0.500 0.333 GO:0034363 CC 1 intermediate-density lipoprotein particle 1 P04114 11 2.40e-03 6 2 1 0.500 0.167 REAC:3000484 rea 1 Scavenging by Class F Receptors 1 P04114 11 2.57e-03 4 2 1 0.500 0.250 GO:0030050 BP 1 vesicle transport along actin filament 1 O43707 11 2.57e-03 4 2 1 0.500 0.250 GO:0010886 BP 1 positive regulation of cholesterol storage 1 P04114 11 2.57e-03 4 2 1 0.500 0.250 GO:0034362 CC 1 low-density lipoprotein particle 1 P04114 11 2.60e-03 306 2 2 1.000 0.007 GO:0015629 CC 1 actin cytoskeleton 1 P04114,O43707 11 3.21e-03 5 2 1 0.500 0.200 GO:0042627 CC 1 chylomicron 1 P04114 11 3.21e-03 5 2 1 0.500 0.200 GO:0010155 BP 1 regulation of proton transport 1 O43707 11 3.58e-03 1 2 1 0.500 1.000 OMIM:144010 omi 1 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, TYPE B;;APOLIPOPROTEIN B-100, FAMILIAL LIGAND-DEFECTIVE;;HYPERCHOLESTEROLEMIA, FAMILIAL, DUE TO LIGAND-DEFECTIVE APOLIPOPROTEINB;;APOLIPOPROTEIN B-100, FAMILIAL DEFECTIVE 1 P04114 11 3.58e-03 1 2 1 0.500 1.000 OMIM:615558 omi 1 Familial Hypobetalipoproteinemia 1 P04114 11 3.86e-03 6 2 1 0.500 0.167 GO:0042159 BP 1 lipoprotein catabolic process 1 P04114 11 3.86e-03 6 2 1 0.500 0.167 GO:0034374 BP 1 low-density lipoprotein particle remodeling 1 P04114 11 3.86e-03 6 2 1 0.500 0.167 GO:0010744 BP 1 positive regulation of macrophage derived foam cell differentiation 1 P04114 11 3.86e-03 6 2 1 0.500 0.167 GO:0099515 BP 1 actin filament-based transport 1 O43707 11 3.86e-03 6 2 1 0.500 0.167 GO:0034379 BP 1 very-low-density lipoprotein particle assembly 1 P04114 11 5.14e-03 8 2 1 0.500 0.125 GO:0010885 BP 1 regulation of cholesterol storage 1 P04114 11 5.14e-03 8 2 1 0.500 0.125 GO:0034361 CC 1 very-low-density lipoprotein particle 1 P04114 11 5.14e-03 8 2 1 0.500 0.125 GO:0034385 CC 1 triglyceride-rich lipoprotein particle 1 P04114 11 5.45e-03 444 2 2 1.000 0.005 REAC:109582 rea 1 Hemostasis 1 P04114,O43707 11 5.78e-03 9 2 1 0.500 0.111 GO:1900025 BP 1 negative regulation of substrate adhesion-dependent cell spreading 1 O43707 11 5.78e-03 9 2 1 0.500 0.111 GO:2000651 BP 1 positive regulation of sodium ion transmembrane transporter activity 1 O43707 11 5.78e-03 9 2 1 0.500 0.111 GO:0031143 CC 1 pseudopodium 1 O43707 11 6.00e-03 15 2 1 0.500 0.067 REAC:3000480 rea 1 Scavenging by Class A Receptors 1 P04114 11 6.00e-03 15 2 1 0.500 0.067 REAC:171052 rea 1 LDL-mediated lipid transport 1 P04114 11 6.40e-03 16 2 1 0.500 0.062 REAC:432142 rea 1 Platelet sensitization by LDL 1 P04114 11 6.43e-03 10 2 1 0.500 0.100 GO:0035357 BP 1 peroxisome proliferator activated receptor signaling pathway 1 O43707 11 6.43e-03 10 2 1 0.500 0.100 GO:0034383 BP 1 low-density lipoprotein particle clearance 1 P04114 11 6.43e-03 10 2 1 0.500 0.100 GO:0010878 BP 1 cholesterol storage 1 P04114 11 6.80e-03 17 2 1 0.500 0.059 REAC:174800 rea 1 Chylomicron-mediated lipid transport 1 P04114 11 6.92e-03 499 2 2 1.000 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 P04114,O43707 11 7.07e-03 11 2 1 0.500 0.091 GO:0017127 MF 1 cholesterol transporter activity 1 P04114 11 7.07e-03 11 2 1 0.500 0.091 GO:0010884 BP 1 positive regulation of lipid storage 1 P04114 11 7.07e-03 11 2 1 0.500 0.091 GO:0034358 CC 1 plasma lipoprotein particle 1 P04114 11 7.07e-03 11 2 1 0.500 0.091 GO:1990777 CC 1 lipoprotein particle 1 P04114 11 7.07e-03 11 2 1 0.500 0.091 GO:0070971 CC 1 endoplasmic reticulum exit site 1 P04114 11 7.71e-03 12 2 1 0.500 0.083 GO:0034367 BP 1 macromolecular complex remodeling 1 P04114 11 7.71e-03 12 2 1 0.500 0.083 GO:0034369 BP 1 plasma lipoprotein particle remodeling 1 P04114 11 7.71e-03 12 2 1 0.500 0.083 GO:0050750 MF 1 low-density lipoprotein particle receptor binding 1 P04114 11 7.71e-03 12 2 1 0.500 0.083 GO:0034368 BP 1 protein-lipid complex remodeling 1 P04114 11 7.71e-03 12 2 1 0.500 0.083 GO:1902307 BP 1 positive regulation of sodium ion transmembrane transport 1 O43707 11 8.11e-03 540 2 2 1.000 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 P04114,O43707 11 8.35e-03 13 2 1 0.500 0.077 GO:0071682 CC 1 endocytic vesicle lumen 1 P04114 11 8.35e-03 13 2 1 0.500 0.077 GO:0034377 BP 1 plasma lipoprotein particle assembly 1 P04114 11 8.35e-03 13 2 1 0.500 0.077 GO:0032994 CC 1 protein-lipid complex 1 P04114 11 8.79e-03 22 2 1 0.500 0.045 REAC:373753 rea 1 Nephrin interactions 1 O43707 11 8.99e-03 14 2 1 0.500 0.071 GO:0042974 MF 1 retinoic acid receptor binding 1 O43707 11 9.64e-03 15 2 1 0.500 0.067 GO:0065005 BP 1 protein-lipid complex assembly 1 P04114 11 9.64e-03 15 2 1 0.500 0.067 GO:0034381 BP 1 plasma lipoprotein particle clearance 1 P04114 11 9.64e-03 15 2 1 0.500 0.067 GO:0048384 BP 1 retinoic acid receptor signaling pathway 1 O43707 11 9.64e-03 15 2 1 0.500 0.067 GO:0010743 BP 1 regulation of macrophage derived foam cell differentiation 1 P04114 11 1.03e-02 16 2 1 0.500 0.062 GO:0015248 MF 1 sterol transporter activity 1 P04114 11 1.03e-02 16 2 1 0.500 0.062 GO:0070325 MF 1 lipoprotein particle receptor binding 1 P04114 11 1.08e-02 15 2 1 0.500 0.067 KEGG:04977 keg 1 Vitamin digestion and absorption 1 P04114 11 1.09e-02 17 2 1 0.500 0.059 GO:0031904 CC 1 endosome lumen 1 P04114 11 1.10e-02 11 2 1 0.500 0.091 TF:M03856_1 tf 1 Factor: Tbx5; motif: YMTYCTCWCACYTGN; match class: 1 1 O43707 11 1.14e-02 640 2 2 1.000 0.003 GO:0016477 BP 1 cell migration 1 P04114,O43707 11 1.20e-02 30 2 1 0.500 0.033 REAC:2173782 rea 1 Binding and Uptake of Ligands by Scavenger Receptors 1 P04114 11 1.24e-02 668 2 2 1.000 0.003 GO:0005615 CC 1 extracellular space 1 P04114,O43707 11 1.28e-02 20 2 1 0.500 0.050 GO:0090077 BP 1 foam cell differentiation 1 P04114 11 1.28e-02 20 2 1 0.500 0.050 GO:0071827 BP 1 plasma lipoprotein particle organization 1 P04114 11 1.28e-02 20 2 1 0.500 0.050 GO:0010765 BP 1 positive regulation of sodium ion transport 1 O43707 11 1.28e-02 20 2 1 0.500 0.050 GO:0010742 BP 1 macrophage derived foam cell differentiation 1 P04114 11 1.32e-02 33 2 1 0.500 0.030 REAC:975634 rea 1 Retinoid metabolism and transport 1 P04114 11 1.35e-02 21 2 1 0.500 0.048 GO:1901224 BP 1 positive regulation of NIK/NF-kappaB signaling 1 O43707 11 1.36e-02 700 2 2 1.000 0.003 GO:0045595 BP 1 regulation of cell differentiation 1 P04114,O43707 11 1.41e-02 711 2 2 1.000 0.003 GO:0051674 BP 1 localization of cell 1 P04114,O43707 11 1.41e-02 711 2 2 1.000 0.003 GO:0048870 BP 1 cell motility 1 P04114,O43707 11 1.41e-02 22 2 1 0.500 0.045 GO:0071825 BP 1 protein-lipid complex subunit organization 1 P04114 11 1.48e-02 23 2 1 0.500 0.043 GO:2000649 BP 1 regulation of sodium ion transmembrane transporter activity 1 O43707 11 1.49e-02 731 2 2 1.000 0.003 GO:0005102 MF 1 receptor binding 1 P04114,O43707 11 1.58e-02 22 2 1 0.500 0.045 KEGG:04975 keg 1 Fat digestion and absorption 1 P04114 11 1.64e-02 41 2 1 0.500 0.024 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 P04114 11 1.67e-02 651 2 2 1.000 0.003 TF:M01123_0 tf 1 Factor: Nanog; motif: GGGNCCATTKCC; match class: 0 1 P04114,O43707 11 1.67e-02 3 2 1 0.500 0.333 CORUM:5655 cor 1 Ternary complex (LRRC7, CAMK2a, ACTN4) 1 O43707 11 1.73e-02 27 2 1 0.500 0.037 GO:0010883 BP 1 regulation of lipid storage 1 P04114 11 1.84e-02 814 2 2 1.000 0.002 GO:0040011 BP 1 locomotion 1 P04114,O43707 11 1.86e-02 29 2 1 0.500 0.034 GO:1901222 BP 1 regulation of NIK/NF-kappaB signaling 1 O43707 11 1.86e-02 29 2 1 0.500 0.034 GO:0097006 BP 1 regulation of plasma lipoprotein particle levels 1 P04114 11 1.95e-02 49 2 1 0.500 0.020 REAC:174824 rea 1 Lipoprotein metabolism 1 P04114 11 1.99e-02 31 2 1 0.500 0.032 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 O43707 11 2.05e-02 32 2 1 0.500 0.031 GO:1902305 BP 1 regulation of sodium ion transmembrane transport 1 O43707 11 2.10e-02 21 2 1 0.500 0.048 TF:M00665_1 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 1 P04114 11 2.12e-02 33 2 1 0.500 0.030 GO:1900024 BP 1 regulation of substrate adhesion-dependent cell spreading 1 O43707 11 2.18e-02 34 2 1 0.500 0.029 GO:0099518 BP 1 vesicle cytoskeletal trafficking 1 O43707 11 2.25e-02 35 2 1 0.500 0.029 GO:0032414 BP 1 positive regulation of ion transmembrane transporter activity 1 O43707 11 2.25e-02 35 2 1 0.500 0.029 GO:0055092 BP 1 sterol homeostasis 1 P04114 11 2.25e-02 35 2 1 0.500 0.029 GO:0042632 BP 1 cholesterol homeostasis 1 P04114 11 2.31e-02 910 2 2 1.000 0.002 GO:0097708 CC 1 intracellular vesicle 1 P04114,O43707 11 2.37e-02 37 2 1 0.500 0.027 GO:0019915 BP 1 lipid storage 1 P04114 11 2.41e-02 931 2 2 1.000 0.002 GO:0031410 CC 1 cytoplasmic vesicle 1 P04114,O43707 11 2.44e-02 38 2 1 0.500 0.026 GO:0030669 CC 1 clathrin-coated endocytic vesicle membrane 1 P04114 11 2.47e-02 62 2 1 0.500 0.016 REAC:2187338 rea 1 Visual phototransduction 1 P04114 11 2.55e-02 958 2 2 1.000 0.002 GO:0016192 BP 1 vesicle-mediated transport 1 P04114,O43707 11 2.57e-02 40 2 1 0.500 0.025 GO:1904064 BP 1 positive regulation of cation transmembrane transport 1 O43707 11 2.63e-02 41 2 1 0.500 0.024 GO:0032411 BP 1 positive regulation of transporter activity 1 O43707 11 2.70e-02 42 2 1 0.500 0.024 GO:0031093 CC 1 platelet alpha granule lumen 1 O43707 11 2.76e-02 43 2 1 0.500 0.023 GO:0030374 MF 1 ligand-dependent nuclear receptor transcription coactivator activity 1 O43707 11 2.79e-02 70 2 1 0.500 0.014 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 P04114 11 2.81e-02 28 2 1 0.500 0.036 TF:M06846_1 tf 1 Factor: ZFHX2; motif: WGWGGTCCCCC; match class: 1 1 P04114 11 2.87e-02 72 2 1 0.500 0.014 REAC:418346 rea 1 Platelet homeostasis 1 P04114 11 2.87e-02 1016 2 2 1.000 0.002 GO:0006928 BP 1 movement of cell or subcellular component 1 P04114,O43707 11 2.89e-02 45 2 1 0.500 0.022 GO:0010771 BP 1 negative regulation of cell morphogenesis involved in differentiation 1 O43707 11 2.91e-02 73 2 1 0.500 0.014 REAC:73923 rea 1 Lipid digestion, mobilization, and transport 1 P04114 11 2.95e-02 46 2 1 0.500 0.022 GO:0045334 CC 1 clathrin-coated endocytic vesicle 1 P04114 11 2.95e-02 46 2 1 0.500 0.022 GO:0002028 BP 1 regulation of sodium ion transport 1 O43707 11 2.96e-02 161 2 1 0.500 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 O43707 11 3.01e-02 30 2 1 0.500 0.033 TF:M06475_1 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 1 1 P04114 11 3.02e-02 47 2 1 0.500 0.021 GO:0034767 BP 1 positive regulation of ion transmembrane transport 1 O43707 11 3.02e-02 47 2 1 0.500 0.021 GO:0001523 BP 1 retinoid metabolic process 1 P04114 11 3.14e-02 49 2 1 0.500 0.020 GO:0016101 BP 1 diterpenoid metabolic process 1 P04114 11 3.14e-02 49 2 1 0.500 0.020 GO:0030301 BP 1 cholesterol transport 1 P04114 11 3.17e-02 1067 2 2 1.000 0.002 GO:0050793 BP 1 regulation of developmental process 1 P04114,O43707 11 3.27e-02 51 2 1 0.500 0.020 GO:0015918 BP 1 sterol transport 1 P04114 11 3.34e-02 52 2 1 0.500 0.019 GO:0034764 BP 1 positive regulation of transmembrane transport 1 O43707 11 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P04114,O43707 11 3.40e-02 53 2 1 0.500 0.019 GO:0015992 BP 1 proton transport 1 O43707 11 3.46e-02 54 2 1 0.500 0.019 GO:0030665 CC 1 clathrin-coated vesicle membrane 1 P04114 11 3.46e-02 54 2 1 0.500 0.019 GO:0006721 BP 1 terpenoid metabolic process 1 P04114 11 3.46e-02 54 2 1 0.500 0.019 GO:0005178 MF 1 integrin binding 1 O43707 11 3.53e-02 55 2 1 0.500 0.018 GO:0006818 BP 1 hydrogen transport 1 O43707 11 3.54e-02 949 2 2 1.000 0.002 TF:M04071_1 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 1 1 P04114,O43707 11 3.59e-02 56 2 1 0.500 0.018 GO:0031091 CC 1 platelet alpha granule 1 O43707 11 3.65e-02 51 2 1 0.500 0.020 KEGG:05322 keg 1 Systemic lupus erythematosus 1 O43707 11 3.66e-02 57 2 1 0.500 0.018 GO:0031490 MF 1 chromatin DNA binding 1 O43707 11 3.66e-02 57 2 1 0.500 0.018 GO:0034774 CC 1 secretory granule lumen 1 O43707 11 3.66e-02 57 2 1 0.500 0.018 GO:0008201 MF 1 heparin binding 1 P04114 11 3.68e-02 2072 2 2 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P04114,O43707 11 3.74e-02 94 2 1 0.500 0.011 REAC:1500931 rea 1 Cell-Cell communication 1 O43707 11 3.78e-02 59 2 1 0.500 0.017 GO:0034446 BP 1 substrate adhesion-dependent cell spreading 1 O43707 11 3.94e-02 99 2 1 0.500 0.010 REAC:114608 rea 1 Platelet degranulation 1 O43707 11 3.97e-02 62 2 1 0.500 0.016 GO:0035725 BP 1 sodium ion transmembrane transport 1 O43707 11 3.99e-02 451 2 2 1.000 0.004 MI:hsa-miR-892b mi 1 MI:hsa-miR-892b 1 P04114,O43707 11 4.04e-02 1204 2 2 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 P04114,O43707 11 4.09e-02 2183 2 2 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P04114,O43707 11 4.13e-02 459 2 2 1.000 0.004 MI:hsa-miR-769-5p mi 1 MI:hsa-miR-769-5p 1 P04114,O43707 11 4.13e-02 104 2 1 0.500 0.010 REAC:76005 rea 1 Response to elevated platelet cytosolic Ca2+ 1 O43707 11 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P04114,O43707 11 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P04114,O43707 11 4.29e-02 67 2 1 0.500 0.015 GO:0008203 BP 1 cholesterol metabolic process 1 P04114 11 4.29e-02 67 2 1 0.500 0.015 GO:1902652 BP 1 secondary alcohol metabolic process 1 P04114 11 4.29e-02 67 2 1 0.500 0.015 GO:0044325 MF 1 ion channel binding 1 O43707 11 4.36e-02 68 2 1 0.500 0.015 GO:0042158 BP 1 lipoprotein biosynthetic process 1 P04114 11 4.36e-02 68 2 1 0.500 0.015 GO:0006720 BP 1 isoprenoid metabolic process 1 P04114 11 4.42e-02 69 2 1 0.500 0.014 GO:0055088 BP 1 lipid homeostasis 1 P04114 11 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P04114,O43707 11 4.50e-02 63 2 1 0.500 0.016 KEGG:05412 keg 1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1 O43707 11 4.51e-02 45 2 1 0.500 0.022 TF:M06555_0 tf 1 Factor: ZNF721; motif: NGGTGTGGGTGC; match class: 0 1 P04114 11 4.55e-02 71 2 1 0.500 0.014 GO:0016125 BP 1 sterol metabolic process 1 P04114 11 4.61e-02 46 2 1 0.500 0.022 TF:M06889_0 tf 1 Factor: znf658b; motif: NTGGNGAAGAGC; match class: 0 1 P04114 11 4.61e-02 46 2 1 0.500 0.022 TF:M06890_0 tf 1 Factor: ZNF658; motif: NTGGNGAAGAGC; match class: 0 1 P04114 11 4.61e-02 72 2 1 0.500 0.014 GO:0005319 MF 1 lipid transporter activity 1 P04114 11 4.91e-02 49 2 1 0.500 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 P04114 11 4.93e-02 77 2 1 0.500 0.013 GO:0030048 BP 1 actin filament-based movement 1 O43707 11 4.98e-02 1125 2 2 1.000 0.002 TF:M04345_0 tf 1 Factor: HOXB13; motif: CCAATAAAAN; match class: 0 1 P04114,O43707 11 5.00e-02 78 2 1 0.500 0.013 GO:0002576 BP 1 platelet degranulation 1 O43707 11 5.00e-02 70 2 1 0.500 0.014 KEGG:04520 keg 1 Adherens junction 1 O43707 11 5.00e-02 1127 2 2 1.000 0.002 TF:M01045_0 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 0 1 P04114,O43707 11 5.00e-02 9 2 1 0.500 0.111 CORUM:725 cor 1 P2X7 receptor signalling complex 1 O43707 11 5.00e-02 126 2 1 0.500 0.008 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P04114 11 5.00e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 P04114,O43707 11 5.00e-02 14 2 1 0.500 0.071 OMIM:603278 omi 1 Focal Segmental Glomerulosclerosis and Nephrotic Syndrome 1 O43707 11 5.00e-02 123 2 2 1.000 0.016 HP:0003119 hp 1 Abnormality of lipid metabolism 1 P04114,O43707 11 5.00e-02 505 2 2 1.000 0.004 MI:hsa-miR-548a-5p mi 1 MI:hsa-miR-548a-5p 1 P04114,O43707 12 1.29e-05 24 2 2 1.000 0.083 GO:0042348 BP 1 NF-kappaB import into nucleus 1 Q9NQC7,Q9NYA1 12 1.29e-05 24 2 2 1.000 0.083 GO:0042345 BP 1 regulation of NF-kappaB import into nucleus 1 Q9NQC7,Q9NYA1 12 3.65e-05 40 2 2 1.000 0.050 GO:0010803 BP 1 regulation of tumor necrosis factor-mediated signaling pathway 1 Q9NQC7,Q9NYA1 12 6.21e-05 52 2 2 1.000 0.038 GO:0042990 BP 1 regulation of transcription factor import into nucleus 1 Q9NQC7,Q9NYA1 12 6.95e-05 55 2 2 1.000 0.036 GO:0042991 BP 1 transcription factor import into nucleus 1 Q9NQC7,Q9NYA1 12 9.14e-05 63 2 2 1.000 0.032 GO:0031503 BP 1 protein complex localization 1 Q9NQC7,Q9NYA1 12 1.79e-04 88 2 2 1.000 0.023 GO:0001959 BP 1 regulation of cytokine-mediated signaling pathway 1 Q9NQC7,Q9NYA1 12 2.05e-04 94 2 2 1.000 0.021 GO:0060759 BP 1 regulation of response to cytokine stimulus 1 Q9NQC7,Q9NYA1 12 2.05e-04 94 2 2 1.000 0.021 GO:0042306 BP 1 regulation of protein import into nucleus 1 Q9NQC7,Q9NYA1 12 2.13e-04 96 2 2 1.000 0.021 GO:1904589 BP 1 regulation of protein import 1 Q9NQC7,Q9NYA1 12 2.65e-04 107 2 2 1.000 0.019 GO:0033209 BP 1 tumor necrosis factor-mediated signaling pathway 1 Q9NQC7,Q9NYA1 12 3.29e-04 119 2 2 1.000 0.017 GO:1900180 BP 1 regulation of protein localization to nucleus 1 Q9NQC7,Q9NYA1 12 3.45e-04 122 2 2 1.000 0.016 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 Q9NQC7,Q9NYA1 12 4.30e-04 136 2 2 1.000 0.015 GO:0071356 BP 1 cellular response to tumor necrosis factor 1 Q9NQC7,Q9NYA1 12 5.02e-04 147 2 2 1.000 0.014 GO:0034612 BP 1 response to tumor necrosis factor 1 Q9NQC7,Q9NYA1 12 5.40e-04 1 2 1 0.500 1.000 GO:0046521 BP 1 sphingoid catabolic process 1 Q9NYA1 12 6.10e-04 162 2 2 1.000 0.012 GO:0043122 BP 1 regulation of I-kappaB kinase/NF-kappaB signaling 1 Q9NQC7,Q9NYA1 12 6.49e-04 167 2 2 1.000 0.012 GO:0044744 BP 1 protein targeting to nucleus 1 Q9NQC7,Q9NYA1 12 6.49e-04 167 2 2 1.000 0.012 GO:0006606 BP 1 protein import into nucleus 1 Q9NQC7,Q9NYA1 12 6.49e-04 167 2 2 1.000 0.012 GO:1902593 BP 1 single-organism nuclear import 1 Q9NQC7,Q9NYA1 12 7.37e-04 178 2 2 1.000 0.011 GO:0007249 BP 1 I-kappaB kinase/NF-kappaB signaling 1 Q9NQC7,Q9NYA1 12 7.79e-04 183 2 2 1.000 0.011 GO:1903533 BP 1 regulation of protein targeting 1 Q9NQC7,Q9NYA1 12 7.88e-04 184 2 2 1.000 0.011 GO:0051170 BP 1 nuclear import 1 Q9NQC7,Q9NYA1 12 1.01e-03 208 2 2 1.000 0.010 GO:0017038 BP 1 protein import 1 Q9NQC7,Q9NYA1 12 1.08e-03 2 2 1 0.500 0.500 GO:0017050 MF 1 D-erythro-sphingosine kinase activity 1 Q9NYA1 12 1.08e-03 2 2 1 0.500 0.500 GO:1990108 BP 1 protein linear deubiquitination 1 Q9NQC7 12 1.08e-03 2 2 1 0.500 0.500 GO:0008481 MF 1 sphinganine kinase activity 1 Q9NYA1 12 1.14e-03 221 2 2 1.000 0.009 GO:0034504 BP 1 protein localization to nucleus 1 Q9NQC7,Q9NYA1 12 1.31e-03 237 2 2 1.000 0.008 GO:0033157 BP 1 regulation of intracellular protein transport 1 Q9NQC7,Q9NYA1 12 1.32e-03 238 2 2 1.000 0.008 GO:0051090 BP 1 regulation of sequence-specific DNA binding transcription factor activity 1 Q9NQC7,Q9NYA1 12 1.62e-03 3 2 1 0.500 0.333 GO:0034312 BP 1 diol biosynthetic process 1 Q9NYA1 12 1.62e-03 3 2 1 0.500 0.333 GO:0038036 MF 1 sphingosine-1-phosphate receptor activity 1 Q9NYA1 12 1.62e-03 3 2 1 0.500 0.333 GO:0001727 MF 1 lipid kinase activity 1 Q9NYA1 12 1.62e-03 3 2 1 0.500 0.333 GO:0046512 BP 1 sphingosine biosynthetic process 1 Q9NYA1 12 1.74e-03 273 2 2 1.000 0.007 GO:0019221 BP 1 cytokine-mediated signaling pathway 1 Q9NQC7,Q9NYA1 12 2.16e-03 4 2 1 0.500 0.250 GO:0034311 BP 1 diol metabolic process 1 Q9NYA1 12 2.16e-03 4 2 1 0.500 0.250 GO:0006670 BP 1 sphingosine metabolic process 1 Q9NYA1 12 2.16e-03 4 2 1 0.500 0.250 GO:0046520 BP 1 sphingoid biosynthetic process 1 Q9NYA1 12 2.24e-03 310 2 2 1.000 0.006 GO:0032386 BP 1 regulation of intracellular transport 1 Q9NQC7,Q9NYA1 12 2.36e-03 318 2 2 1.000 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q9NQC7,Q9NYA1 12 2.45e-03 324 2 2 1.000 0.006 GO:0051169 BP 1 nuclear transport 1 Q9NQC7,Q9NYA1 12 2.70e-03 5 2 1 0.500 0.200 GO:0045125 MF 1 bioactive lipid receptor activity 1 Q9NYA1 12 2.70e-03 5 2 1 0.500 0.200 GO:0061578 MF 1 Lys63-specific deubiquitinase activity 1 Q9NQC7 12 2.71e-03 341 2 2 1.000 0.006 GO:0071345 BP 1 cellular response to cytokine stimulus 1 Q9NQC7,Q9NYA1 12 3.07e-03 363 2 2 1.000 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q9NQC7,Q9NYA1 12 3.16e-03 368 2 2 1.000 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 Q9NQC7,Q9NYA1 12 3.24e-03 6 2 1 0.500 0.167 GO:0046519 BP 1 sphingoid metabolic process 1 Q9NYA1 12 3.59e-03 392 2 2 1.000 0.005 GO:0034097 BP 1 response to cytokine 1 Q9NQC7,Q9NYA1 12 3.78e-03 7 2 1 0.500 0.143 GO:0045987 BP 1 positive regulation of smooth muscle contraction 1 Q9NYA1 12 3.87e-03 407 2 2 1.000 0.005 GO:0051223 BP 1 regulation of protein transport 1 Q9NQC7,Q9NYA1 12 5.09e-03 467 2 2 1.000 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 Q9NQC7,Q9NYA1 12 5.29e-03 10 2 1 0.500 0.100 REAC:5357786 rea 1 TNFR1-induced proapoptotic signaling 1 Q9NQC7 12 5.49e-03 485 2 2 1.000 0.004 GO:0072594 BP 1 establishment of protein localization to organelle 1 Q9NQC7,Q9NYA1 12 5.54e-03 487 2 2 1.000 0.004 GO:0006605 BP 1 protein targeting 1 Q9NQC7,Q9NYA1 12 5.94e-03 11 2 1 0.500 0.091 GO:0042346 BP 1 positive regulation of NF-kappaB import into nucleus 1 Q9NYA1 12 6.07e-03 510 2 2 1.000 0.004 GO:0060341 BP 1 regulation of cellular localization 1 Q9NQC7,Q9NYA1 12 6.47e-03 12 2 1 0.500 0.083 GO:0045933 BP 1 positive regulation of muscle contraction 1 Q9NYA1 12 6.47e-03 12 2 1 0.500 0.083 GO:0070064 MF 1 proline-rich region binding 1 Q9NQC7 12 6.91e-03 544 2 2 1.000 0.004 GO:0032880 BP 1 regulation of protein localization 1 Q9NQC7,Q9NYA1 12 7.55e-03 14 2 1 0.500 0.071 GO:0010800 BP 1 positive regulation of peptidyl-threonine phosphorylation 1 Q9NYA1 12 7.55e-03 14 2 1 0.500 0.071 GO:0030149 BP 1 sphingolipid catabolic process 1 Q9NYA1 12 7.70e-03 574 2 2 1.000 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 Q9NQC7,Q9NYA1 12 8.21e-03 593 2 2 1.000 0.003 GO:0046872 MF 1 metal ion binding 1 Q9NQC7,Q9NYA1 12 8.63e-03 16 2 1 0.500 0.062 GO:0042347 BP 1 negative regulation of NF-kappaB import into nucleus 1 Q9NQC7 12 8.63e-03 16 2 1 0.500 0.062 GO:0006940 BP 1 regulation of smooth muscle contraction 1 Q9NYA1 12 8.63e-03 16 2 1 0.500 0.062 GO:0046466 BP 1 membrane lipid catabolic process 1 Q9NYA1 12 9.17e-03 17 2 1 0.500 0.059 GO:0046173 BP 1 polyol biosynthetic process 1 Q9NYA1 12 9.71e-03 18 2 1 0.500 0.056 GO:0051721 MF 1 protein phosphatase 2A binding 1 Q9NYA1 12 9.99e-03 654 2 2 1.000 0.003 GO:0043169 MF 1 cation binding 1 Q9NQC7,Q9NYA1 12 1.01e-02 657 2 2 1.000 0.003 GO:0033365 BP 1 protein localization to organelle 1 Q9NQC7,Q9NYA1 12 1.02e-02 662 2 2 1.000 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q9NQC7,Q9NYA1 12 1.08e-02 679 2 2 1.000 0.003 GO:0051726 BP 1 regulation of cell cycle 1 Q9NQC7,Q9NYA1 12 1.17e-02 709 2 2 1.000 0.003 GO:0006886 BP 1 intracellular protein transport 1 Q9NQC7,Q9NYA1 12 1.19e-02 22 2 1 0.500 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 Q9NYA1 12 1.19e-02 22 2 1 0.500 0.045 GO:2001238 BP 1 positive regulation of extrinsic apoptotic signaling pathway 1 Q9NQC7 12 1.21e-02 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q9NQC7,Q9NYA1 12 1.22e-02 23 2 1 0.500 0.043 REAC:5357956 rea 1 TNFR1-induced NFkappaB signaling pathway 1 Q9NQC7 12 1.24e-02 23 2 1 0.500 0.043 GO:0010799 BP 1 regulation of peptidyl-threonine phosphorylation 1 Q9NYA1 12 1.24e-02 23 2 1 0.500 0.043 GO:0070536 BP 1 protein K63-linked deubiquitination 1 Q9NQC7 12 1.24e-02 23 2 1 0.500 0.043 GO:0070266 BP 1 necroptotic process 1 Q9NQC7 12 1.30e-02 746 2 2 1.000 0.003 GO:0042981 BP 1 regulation of apoptotic process 1 Q9NQC7,Q9NYA1 12 1.34e-02 756 2 2 1.000 0.003 GO:0043067 BP 1 regulation of programmed cell death 1 Q9NQC7,Q9NYA1 12 1.35e-02 25 2 1 0.500 0.040 GO:0097300 BP 1 programmed necrotic cell death 1 Q9NQC7 12 1.36e-02 763 2 2 1.000 0.003 GO:0009967 BP 1 positive regulation of signal transduction 1 Q9NQC7,Q9NYA1 12 1.39e-02 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 Q9NQC7,Q9NYA1 12 1.43e-02 27 2 1 0.500 0.037 REAC:936440 rea 1 Negative regulators of RIG-I/MDA5 signaling 1 Q9NQC7 12 1.46e-02 27 2 1 0.500 0.037 GO:0032480 BP 1 negative regulation of type I interferon production 1 Q9NQC7 12 1.46e-02 27 2 1 0.500 0.037 GO:0042992 BP 1 negative regulation of transcription factor import into nucleus 1 Q9NQC7 12 1.48e-02 28 2 1 0.500 0.036 REAC:5357905 rea 1 Regulation of TNFR1 signaling 1 Q9NQC7 12 1.49e-02 798 2 2 1.000 0.003 GO:0010647 BP 1 positive regulation of cell communication 1 Q9NQC7,Q9NYA1 12 1.51e-02 28 2 1 0.500 0.036 GO:0042993 BP 1 positive regulation of transcription factor import into nucleus 1 Q9NYA1 12 1.51e-02 804 2 2 1.000 0.002 GO:0023056 BP 1 positive regulation of signaling 1 Q9NQC7,Q9NYA1 12 1.54e-02 811 2 2 1.000 0.002 GO:0010941 BP 1 regulation of cell death 1 Q9NQC7,Q9NYA1 12 1.58e-02 30 2 1 0.500 0.033 REAC:168638 rea 1 NOD1/2 Signaling Pathway 1 Q9NQC7 12 1.62e-02 30 2 1 0.500 0.033 GO:0070423 BP 1 nucleotide-binding oligomerization domain containing signaling pathway 1 Q9NQC7 12 1.67e-02 31 2 1 0.500 0.032 GO:0035872 BP 1 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 1 Q9NQC7 12 1.72e-02 32 2 1 0.500 0.031 GO:0006939 BP 1 smooth muscle contraction 1 Q9NYA1 12 1.74e-02 33 2 1 0.500 0.030 REAC:1660661 rea 1 Sphingolipid de novo biosynthesis 1 Q9NYA1 12 1.83e-02 34 2 1 0.500 0.029 GO:0070265 BP 1 necrotic cell death 1 Q9NQC7 12 1.89e-02 35 2 1 0.500 0.029 GO:0005881 CC 1 cytoplasmic microtubule 1 Q9NQC7 12 1.95e-02 37 2 1 0.500 0.027 REAC:390471 rea 1 Association of TriC/CCT with target proteins during biosynthesis 1 Q9NYA1 12 1.99e-02 37 2 1 0.500 0.027 GO:0043124 BP 1 negative regulation of I-kappaB kinase/NF-kappaB signaling 1 Q9NQC7 12 1.99e-02 37 2 1 0.500 0.027 GO:0048145 BP 1 regulation of fibroblast proliferation 1 Q9NYA1 12 2.01e-02 38 2 1 0.500 0.026 REAC:75893 rea 1 TNF signaling 1 Q9NQC7 12 2.05e-02 936 2 2 1.000 0.002 GO:0006915 BP 1 apoptotic process 1 Q9NQC7,Q9NYA1 12 2.05e-02 936 2 2 1.000 0.002 GO:0051049 BP 1 regulation of transport 1 Q9NQC7,Q9NYA1 12 2.05e-02 38 2 1 0.500 0.026 GO:0048144 BP 1 fibroblast proliferation 1 Q9NYA1 12 2.14e-02 956 2 2 1.000 0.002 GO:0012501 BP 1 programmed cell death 1 Q9NQC7,Q9NYA1 12 2.16e-02 40 2 1 0.500 0.025 GO:1904590 BP 1 negative regulation of protein import 1 Q9NQC7 12 2.16e-02 40 2 1 0.500 0.025 GO:0042308 BP 1 negative regulation of protein import into nucleus 1 Q9NQC7 12 2.17e-02 964 2 2 1.000 0.002 GO:0015031 BP 1 protein transport 1 Q9NQC7,Q9NYA1 12 2.21e-02 41 2 1 0.500 0.024 GO:0097542 CC 1 ciliary tip 1 Q9NQC7 12 2.26e-02 42 2 1 0.500 0.024 GO:0002753 BP 1 cytoplasmic pattern recognition receptor signaling pathway 1 Q9NQC7 12 2.27e-02 43 2 1 0.500 0.023 REAC:73887 rea 1 Death Receptor Signalling 1 Q9NQC7 12 2.32e-02 43 2 1 0.500 0.023 GO:1900181 BP 1 negative regulation of protein localization to nucleus 1 Q9NQC7 12 2.32e-02 44 2 1 0.500 0.023 REAC:168643 rea 1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 1 Q9NQC7 12 2.42e-02 45 2 1 0.500 0.022 GO:0032088 BP 1 negative regulation of NF-kappaB transcription factor activity 1 Q9NQC7 12 2.47e-02 1027 2 2 1.000 0.002 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q9NQC7,Q9NYA1 12 2.48e-02 1029 2 2 1.000 0.002 GO:0008219 BP 1 cell death 1 Q9NQC7,Q9NYA1 12 2.48e-02 46 2 1 0.500 0.022 GO:0046823 BP 1 negative regulation of nucleocytoplasmic transport 1 Q9NQC7 12 2.59e-02 48 2 1 0.500 0.021 GO:1902017 BP 1 regulation of cilium assembly 1 Q9NQC7 12 2.75e-02 51 2 1 0.500 0.020 GO:0042307 BP 1 positive regulation of protein import into nucleus 1 Q9NYA1 12 2.76e-02 1086 2 2 1.000 0.002 GO:0048584 BP 1 positive regulation of response to stimulus 1 Q9NQC7,Q9NYA1 12 2.80e-02 52 2 1 0.500 0.019 GO:1904591 BP 1 positive regulation of protein import 1 Q9NYA1 12 2.80e-02 52 2 1 0.500 0.019 GO:0045766 BP 1 positive regulation of angiogenesis 1 Q9NYA1 12 2.83e-02 1100 2 2 1.000 0.002 GO:0045184 BP 1 establishment of protein localization 1 Q9NQC7,Q9NYA1 12 2.89e-02 1111 2 2 1.000 0.002 GO:0034613 BP 1 cellular protein localization 1 Q9NQC7,Q9NYA1 12 2.94e-02 1121 2 2 1.000 0.002 GO:0070727 BP 1 cellular macromolecule localization 1 Q9NQC7,Q9NYA1 12 2.97e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 Q9NQC7,Q9NYA1 12 3.07e-02 57 2 1 0.500 0.018 GO:0090317 BP 1 negative regulation of intracellular protein transport 1 Q9NQC7 12 3.12e-02 58 2 1 0.500 0.017 GO:0005516 MF 1 calmodulin binding 1 Q9NYA1 12 3.12e-02 58 2 1 0.500 0.017 GO:0018107 BP 1 peptidyl-threonine phosphorylation 1 Q9NYA1 12 3.13e-02 1157 2 2 1.000 0.002 GO:0071310 BP 1 cellular response to organic substance 1 Q9NQC7,Q9NYA1 12 3.27e-02 62 2 1 0.500 0.016 REAC:168928 rea 1 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 1 Q9NQC7 12 3.28e-02 61 2 1 0.500 0.016 GO:0019751 BP 1 polyol metabolic process 1 Q9NYA1 12 3.28e-02 61 2 1 0.500 0.016 GO:0018210 BP 1 peptidyl-threonine modification 1 Q9NYA1 12 3.28e-02 61 2 1 0.500 0.016 GO:1904018 BP 1 positive regulation of vasculature development 1 Q9NYA1 12 3.34e-02 62 2 1 0.500 0.016 GO:0046165 BP 1 alcohol biosynthetic process 1 Q9NYA1 12 3.39e-02 63 2 1 0.500 0.016 GO:0036064 CC 1 ciliary basal body 1 Q9NQC7 12 3.45e-02 64 2 1 0.500 0.016 GO:0030148 BP 1 sphingolipid biosynthetic process 1 Q9NYA1 12 3.45e-02 64 2 1 0.500 0.016 GO:0004843 MF 1 thiol-dependent ubiquitin-specific protease activity 1 Q9NQC7 12 3.45e-02 64 2 1 0.500 0.016 GO:0036459 MF 1 thiol-dependent ubiquitinyl hydrolase activity 1 Q9NQC7 12 3.50e-02 65 2 1 0.500 0.015 GO:0046824 BP 1 positive regulation of nucleocytoplasmic transport 1 Q9NYA1 12 3.54e-02 1230 2 2 1.000 0.002 GO:0019899 MF 1 enzyme binding 1 Q9NQC7,Q9NYA1 12 3.55e-02 66 2 1 0.500 0.015 GO:0032387 BP 1 negative regulation of intracellular transport 1 Q9NQC7 12 3.58e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 Q9NQC7,Q9NYA1 12 3.61e-02 67 2 1 0.500 0.015 GO:0101005 MF 1 ubiquitinyl hydrolase activity 1 Q9NQC7 12 3.66e-02 68 2 1 0.500 0.015 GO:0006937 BP 1 regulation of muscle contraction 1 Q9NYA1 12 3.71e-02 69 2 1 0.500 0.014 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 Q9NYA1 12 3.73e-02 1263 2 2 1.000 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 Q9NQC7,Q9NYA1 12 3.79e-02 72 2 1 0.500 0.014 REAC:428157 rea 1 Sphingolipid metabolism 1 Q9NYA1 12 3.82e-02 71 2 1 0.500 0.014 GO:0019903 MF 1 protein phosphatase binding 1 Q9NYA1 12 3.87e-02 72 2 1 0.500 0.014 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 Q9NYA1 12 3.87e-02 72 2 1 0.500 0.014 GO:0031234 CC 1 extrinsic component of cytoplasmic side of plasma membrane 1 Q9NQC7 12 3.90e-02 1291 2 2 1.000 0.002 GO:0043167 MF 1 ion binding 1 Q9NQC7,Q9NYA1 12 3.97e-02 5 2 1 0.500 0.200 TF:M06849_1 tf 1 Factor: ZNF528; motif: NSTCCGGAAGA; match class: 1 1 Q9NYA1 12 4.04e-02 75 2 1 0.500 0.013 GO:0019783 MF 1 ubiquitin-like protein-specific protease activity 1 Q9NQC7 12 4.14e-02 77 2 1 0.500 0.013 GO:0019722 BP 1 calcium-mediated signaling 1 Q9NYA1 12 4.20e-02 78 2 1 0.500 0.013 GO:0032606 BP 1 type I interferon production 1 Q9NQC7 12 4.20e-02 78 2 1 0.500 0.013 GO:0032479 BP 1 regulation of type I interferon production 1 Q9NQC7 12 4.20e-02 78 2 1 0.500 0.013 GO:0030307 BP 1 positive regulation of cell growth 1 Q9NYA1 12 4.20e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 Q9NQC7,Q9NYA1 12 4.41e-02 82 2 1 0.500 0.012 GO:0043433 BP 1 negative regulation of sequence-specific DNA binding transcription factor activity 1 Q9NQC7 12 4.43e-02 1377 2 2 1.000 0.001 GO:0071702 BP 1 organic substance transport 1 Q9NQC7,Q9NYA1 12 4.46e-02 83 2 1 0.500 0.012 GO:2001236 BP 1 regulation of extrinsic apoptotic signaling pathway 1 Q9NQC7 12 4.50e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 Q9NQC7,Q9NYA1 12 4.52e-02 84 2 1 0.500 0.012 GO:0070507 BP 1 regulation of microtubule cytoskeleton organization 1 Q9NQC7 12 4.52e-02 86 2 1 0.500 0.012 REAC:390466 rea 1 Chaperonin-mediated protein folding 1 Q9NYA1 12 4.54e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 Q9NQC7,Q9NYA1 12 4.54e-02 1394 2 2 1.000 0.001 GO:0010033 BP 1 response to organic substance 1 Q9NQC7,Q9NYA1 12 4.57e-02 85 2 1 0.500 0.012 GO:0090257 BP 1 regulation of muscle system process 1 Q9NYA1 12 4.63e-02 86 2 1 0.500 0.012 GO:1903828 BP 1 negative regulation of cellular protein localization 1 Q9NQC7 12 4.63e-02 86 2 1 0.500 0.012 GO:0016579 BP 1 protein deubiquitination 1 Q9NQC7 12 4.69e-02 1416 2 2 1.000 0.001 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q9NQC7,Q9NYA1 12 4.73e-02 88 2 1 0.500 0.011 GO:0046467 BP 1 membrane lipid biosynthetic process 1 Q9NYA1 12 4.73e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q9NQC7,Q9NYA1 12 4.84e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 Q9NQC7,Q9NYA1 12 4.84e-02 92 2 1 0.500 0.011 REAC:391251 rea 1 Protein folding 1 Q9NYA1 12 5.00e-02 1 2 1 0.500 1.000 OMIM:605041 omi 1 BROOKE-SPIEGLER SYNDROME; BRSS;;BSS;;SPIEGLER-BROOKE SYNDROME; SBS 1 Q9NQC7 12 5.00e-02 14 2 1 0.500 0.071 HP:0001056 hp 1 Milia 1 Q9NQC7 12 5.00e-02 93 2 1 0.500 0.011 GO:2001242 BP 1 regulation of intrinsic apoptotic signaling pathway 1 Q9NQC7 12 5.00e-02 38 2 1 0.500 0.026 KEGG:00600 keg 1 Sphingolipid metabolism 1 Q9NYA1 12 5.00e-02 1 2 1 0.500 1.000 OMIM:132700 omi 1 CYLINDROMATOSIS, FAMILIAL;;ANCELL-SPIEGLER CYLINDROMAS;;'TURBAN TUMOR' SYNDROME;;CYLINDROMAS, DERMAL ECCRINE 1 Q9NQC7 12 5.00e-02 1169 2 2 1.000 0.002 REAC:392499 rea 1 Metabolism of proteins 1 Q9NQC7,Q9NYA1 12 5.00e-02 349 2 2 1.000 0.006 MI:hsa-miR-197 mi 1 MI:hsa-miR-197 1 Q9NQC7,Q9NYA1 12 5.00e-02 401 2 2 1.000 0.005 TF:M04322_0 tf 1 Factor: GBX1; motif: NCYAATTANN; match class: 0 1 Q9NQC7,Q9NYA1 12 5.00e-02 1 2 1 0.500 1.000 OMIM:601606 omi 1 TRICHOEPITHELIOMA, MULTIPLE FAMILIAL, 1;;MFT1;;EPITHELIOMA ADENOIDES CYSTICUM OF BROOKE; EAC;;EPITHELIOMA, HEREDITARY MULTIPLE BENIGN CYSTIC;;BROOKE-FORDYCE TRICHOEPITHELIOMAS 1 Q9NQC7 13 8.35e-03 2 6 1 0.167 0.500 GO:0050220 MF 1 prostaglandin-E synthase activity 1 O14684 13 1.13e-02 1932 6 4 0.667 0.002 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 Q9UI14,Q9HBL7,O14684,O94919 13 1.28e-02 1998 6 4 0.667 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q9UI14,Q9HBL7,O14684,O94919 13 1.54e-02 376 6 2 0.333 0.005 MI:hsa-miR-218-2* mi 1 MI:hsa-miR-218-2* 1 Q9HBL7,O14684 13 1.61e-02 385 6 2 0.333 0.005 MI:hsa-miR-635 mi 1 MI:hsa-miR-635 1 Q9HBL7,O14684 13 1.68e-02 393 6 2 0.333 0.005 MI:rno-miR-352 mi 1 MI:rno-miR-352 1 Q9UI14,Q9UBU6 13 1.80e-02 408 6 2 0.333 0.005 MI:hsa-miR-570 mi 1 MI:hsa-miR-570 1 Q9HBL7,Q9Y3E0 13 1.81e-02 2200 6 4 0.667 0.002 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 Q9UI14,Q9HBL7,O14684,O94919 13 1.85e-02 414 6 2 0.333 0.005 MI:hsa-miR-331-5p mi 1 MI:hsa-miR-331-5p 1 Q9UI14,O14684 13 2.04e-02 2274 6 4 0.667 0.002 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.09e-02 2290 6 4 0.667 0.002 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.11e-02 2295 6 4 0.667 0.002 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.14e-02 447 6 2 0.333 0.004 MI:hsa-miR-517a mi 1 MI:hsa-miR-517a 1 Q9Y3E0,O14684 13 2.21e-02 4187 6 6 1.000 0.001 TF:M00712_1 tf 1 Factor: myogenin; motif: RGCAGSTG; match class: 1 1 Q9UI14,Q9HBL7,Q9Y3E0,Q9UBU6,O14684,O94919 13 2.30e-02 464 6 2 0.333 0.004 MI:hsa-miR-517c mi 1 MI:hsa-miR-517c 1 Q9Y3E0,O14684 13 2.36e-02 2366 6 4 0.667 0.002 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.37e-02 454 6 2 0.333 0.004 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q9UI14,Q9HBL7 13 2.40e-02 475 6 2 0.333 0.004 MI:hsa-miR-425 mi 1 MI:hsa-miR-425 1 Q9UI14,Q9Y3E0 13 2.46e-02 2395 6 4 0.667 0.002 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.50e-02 6 6 1 0.167 0.167 GO:0019371 BP 1 cyclooxygenase pathway 1 O14684 13 2.52e-02 548 6 3 0.500 0.005 TF:M00194_0 tf 1 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN; match class: 0 1 Q9UI14,Q9HBL7,O14684 13 2.61e-02 2435 6 4 0.667 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 2.67e-02 1307 6 3 0.500 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q9UI14,Q9HBL7,O94919 13 2.72e-02 1317 6 3 0.500 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 Q9UI14,Q9HBL7,O94919 13 2.89e-02 2505 6 4 0.667 0.002 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 Q9UI14,Q9HBL7,O14684,O94919 13 3.04e-02 538 6 2 0.333 0.004 MI:mmu-miR-291a-5p mi 1 MI:mmu-miR-291a-5p 1 Q9UI14,Q9HBL7 13 3.09e-02 543 6 2 0.333 0.004 MI:mmu-miR-291b-5p mi 1 MI:mmu-miR-291b-5p 1 Q9UI14,Q9HBL7 13 3.18e-02 2574 6 4 0.667 0.002 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 Q9UI14,Q9HBL7,O14684,O94919 13 3.55e-02 1453 6 3 0.500 0.002 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9UI14,Q9HBL7,O94919 13 3.59e-02 567 6 2 0.333 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 Q9HBL7,O94919 13 3.69e-02 2697 6 5 0.833 0.002 TF:M07046_0 tf 1 Factor: LEF-1; motif: ANNWWCAAAGN; match class: 0 1 Q9UI14,Q9HBL7,Q9Y3E0,Q9UBU6,O14684 13 3.75e-02 9 6 1 0.167 0.111 GO:0043295 MF 1 glutathione binding 1 O14684 13 3.90e-02 615 6 2 0.333 0.003 MI:hsa-miR-548a-3p mi 1 MI:hsa-miR-548a-3p 1 Q9HBL7,Q9Y3E0 13 4.17e-02 10 6 1 0.167 0.100 GO:1900750 MF 1 oligopeptide binding 1 O14684 13 4.28e-02 624 6 2 0.333 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q9HBL7,O14684 13 4.46e-02 1583 6 3 0.500 0.002 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 Q9UI14,Q9HBL7,O94919 13 4.48e-02 2839 6 4 0.667 0.001 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 Q9UI14,Q9HBL7,O14684,O94919 13 4.62e-02 650 6 2 0.333 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q9HBL7,O14684 13 4.73e-02 1619 6 3 0.500 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O94919 13 4.74e-02 1621 6 3 0.500 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q9UI14,Q9HBL7,O94919 13 4.76e-02 1623 6 3 0.500 0.002 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q9UI14,Q9HBL7,O94919 13 4.91e-02 2914 6 4 0.667 0.001 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 Q9UI14,Q9HBL7,O14684,O94919 13 5.00e-02 12 6 1 0.167 0.083 GO:0001516 BP 1 prostaglandin biosynthetic process 1 O14684 13 5.00e-02 36 6 1 0.167 0.028 KEGG:00590 keg 1 Arachidonic acid metabolism 1 O14684 13 5.00e-02 12 6 1 0.167 0.083 GO:0046457 BP 1 prostanoid biosynthetic process 1 O14684 13 5.00e-02 1576 6 4 0.667 0.003 TF:M00086_1 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 1 1 Q9UI14,Q9HBL7,Q9UBU6,O14684 14 1.25e-19 48 8 8 1.000 0.167 GO:0008023 CC 1 transcription elongation factor complex 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 6.76e-12 57 8 6 0.750 0.105 REAC:75955 rea 1 RNA Polymerase II Transcription Elongation 1 Q9UHB7,O60583,O60563,Q03111,P50750,P42568 14 6.76e-12 57 8 6 0.750 0.105 REAC:112382 rea 1 Formation of RNA Pol II elongation complex 1 Q9UHB7,O60583,O60563,Q03111,P50750,P42568 14 4.22e-11 521 8 8 1.000 0.015 GO:0044451 CC 1 nucleoplasm part 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 5.15e-11 79 8 6 0.750 0.076 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 Q9UHB7,O60583,O60563,Q03111,P50750,P42568 14 1.71e-09 140 8 6 0.750 0.043 REAC:73857 rea 1 RNA Polymerase II Transcription 1 Q9UHB7,O60583,O60563,Q03111,P50750,P42568 14 1.12e-08 6 8 3 0.375 0.500 GO:0097322 MF 1 7SK snRNA binding 1 O60583,O60563,P50750 14 1.12e-08 6 8 3 0.375 0.500 GO:0008024 CC 1 cyclin/CDK positive transcription elongation factor complex 1 O60583,O60563,P50750 14 2.04e-07 14 8 3 0.375 0.214 GO:0019908 CC 1 nuclear cyclin-dependent protein kinase holoenzyme complex 1 O60583,O60563,P50750 14 2.19e-07 70 8 4 0.500 0.057 GO:0009301 BP 1 snRNA transcription 1 O60583,O00472,O60563,P50750 14 2.19e-07 70 8 4 0.500 0.057 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 O60583,O00472,O60563,P50750 14 4.59e-07 84 8 4 0.500 0.048 GO:0016073 BP 1 snRNA metabolic process 1 O60583,O00472,O60563,P50750 14 5.80e-07 89 8 4 0.500 0.045 GO:0006368 BP 1 transcription elongation from RNA polymerase II promoter 1 O60583,O00472,O60563,P50750 14 6.36e-07 20 8 3 0.375 0.150 GO:0032806 CC 1 carboxy-terminal domain protein kinase complex 1 O60583,O60563,P50750 14 6.64e-07 92 8 4 0.500 0.043 GO:0098781 BP 1 ncRNA transcription 1 O60583,O00472,O60563,P50750 14 7.29e-07 70 8 4 0.500 0.057 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 O60583,O00472,O60563,P50750 14 1.63e-06 115 8 4 0.500 0.035 GO:0006354 BP 1 DNA-templated transcription, elongation 1 O60583,O00472,O60563,P50750 14 2.26e-06 30 8 3 0.375 0.100 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 O60583,O60563,P50750 14 2.50e-06 31 8 3 0.375 0.097 GO:0017069 MF 1 snRNA binding 1 O60583,O60563,P50750 14 3.01e-06 2096 8 8 1.000 0.004 GO:0043234 CC 1 protein complex 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 4.27e-06 29 8 3 0.375 0.103 REAC:2173796 rea 1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1 O60583,O60563,P50750 14 4.27e-06 3 8 2 0.250 0.667 REAC:176034 rea 1 Interactions of Tat with host cellular proteins 1 O60563,P50750 14 5.78e-06 32 8 3 0.375 0.094 REAC:167287 rea 1 HIV elongation arrest and recovery 1 O60583,O60563,P50750 14 5.78e-06 32 8 3 0.375 0.094 REAC:167290 rea 1 Pausing and recovery of HIV elongation 1 O60583,O60563,P50750 14 1.08e-05 5 8 2 0.250 0.400 GO:0001223 MF 1 transcription coactivator binding 1 O60583,P50750 14 1.24e-05 41 8 3 0.375 0.073 REAC:2173793 rea 1 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1 O60583,O60563,P50750 14 1.36e-05 2529 8 8 1.000 0.003 GO:0005654 CC 1 nucleoplasm 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 1.53e-05 44 8 3 0.375 0.068 REAC:167152 rea 1 Formation of HIV elongation complex in the absence of HIV Tat 1 O60583,O60563,P50750 14 1.54e-05 2 8 2 0.250 1.000 CORUM:1082 cor 1 P-TEFb.1 complex 1 O60563,P50750 14 1.54e-05 2 8 2 0.250 1.000 CORUM:1080 cor 1 P-TEFb.2 complex 1 O60583,P50750 14 1.54e-05 2 8 2 0.250 1.000 CORUM:1079 cor 1 P-TEFb.1 complex 1 O60563,P50750 14 3.01e-05 70 8 3 0.375 0.043 GO:1902554 CC 1 serine/threonine protein kinase complex 1 O60583,O60563,P50750 14 3.01e-05 8 8 2 0.250 0.250 GO:1900364 BP 1 negative regulation of mRNA polyadenylation 1 O60563,P50750 14 3.01e-05 8 8 2 0.250 0.250 GO:1901409 BP 1 positive regulation of phosphorylation of RNA polymerase II C-terminal domain 1 O60583,O60563 14 3.01e-05 8 8 2 0.250 0.250 GO:0001221 MF 1 transcription cofactor binding 1 O60583,P50750 14 3.87e-05 9 8 2 0.250 0.222 GO:0031441 BP 1 negative regulation of mRNA 3'-end processing 1 O60563,P50750 14 3.87e-05 9 8 2 0.250 0.222 GO:1901407 BP 1 regulation of phosphorylation of RNA polymerase II C-terminal domain 1 O60583,O60563 14 3.93e-05 60 8 3 0.375 0.050 REAC:6796648 rea 1 TP53 Regulates Transcription of DNA Repair Genes 1 O60583,O60563,P50750 14 4.42e-05 2931 8 8 1.000 0.003 GO:0031981 CC 1 nuclear lumen 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2873 cor 1 P-TEFb-7SKRNA-HEXIM1 complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2604 cor 1 P-TEFb-SKP2 complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2877 cor 1 BRD4-P-TEFb complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2878 cor 1 P-TEFb-7SKRNA-HEXIM1 complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2605 cor 1 Heterotrimeric complex (CCNT1, CDK9, GRN) 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2603 cor 1 Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2875 cor 1 BRD4-P-TEFb complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:2602 cor 1 P-TEFb-7SKRNA-HEXIM1 complex 1 O60563,P50750 14 4.62e-05 3 8 2 0.250 0.667 CORUM:1457 cor 1 AFF1-MLLT1-CBX8 complex 1 Q03111,P51825 14 4.67e-05 81 8 3 0.375 0.037 GO:1902911 CC 1 protein kinase complex 1 O60583,O60563,P50750 14 5.48e-05 67 8 3 0.375 0.045 REAC:170834 rea 1 Signaling by TGF-beta Receptor Complex 1 O60583,O60563,P50750 14 5.92e-05 11 8 2 0.250 0.182 GO:1900363 BP 1 regulation of mRNA polyadenylation 1 O60563,P50750 14 5.99e-05 69 8 3 0.375 0.043 REAC:167172 rea 1 Transcription of the HIV genome 1 O60583,O60563,P50750 14 6.68e-05 1177 8 6 0.750 0.005 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 8.24e-05 3168 8 8 1.000 0.003 GO:0044428 CC 1 nuclear part 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 9.23e-05 4 8 2 0.250 0.500 CORUM:2601 cor 1 P-TEFb-BRD4-TRAP220 complex 1 O60563,P50750 14 9.78e-05 14 8 2 0.250 0.143 GO:0070816 BP 1 phosphorylation of RNA polymerase II C-terminal domain 1 O60583,O60563 14 1.34e-04 1485 8 7 0.875 0.005 REAC:74160 rea 1 Gene Expression 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568 14 1.50e-04 3415 8 8 1.000 0.002 GO:0032991 CC 1 macromolecular complex 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 1.54e-04 5 8 2 0.250 0.400 CORUM:2599 cor 1 POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex 1 O60563,P50750 14 1.64e-04 18 8 2 0.250 0.111 GO:0031440 BP 1 regulation of mRNA 3'-end processing 1 O60563,P50750 14 2.10e-04 3561 8 8 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 2.10e-04 3561 8 8 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 2.10e-04 3561 8 8 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 2.25e-04 21 8 2 0.250 0.095 GO:0016538 MF 1 cyclin-dependent protein serine/threonine kinase regulator activity 1 O60583,O60563 14 2.71e-04 23 8 2 0.250 0.087 GO:0050686 BP 1 negative regulation of mRNA processing 1 O60563,P50750 14 3.21e-04 25 8 2 0.250 0.080 GO:0045737 BP 1 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1 O60583,O60563 14 3.21e-04 25 8 2 0.250 0.080 GO:1904031 BP 1 positive regulation of cyclin-dependent protein kinase activity 1 O60583,O60563 14 3.75e-04 27 8 2 0.250 0.074 GO:1903312 BP 1 negative regulation of mRNA metabolic process 1 O60563,P50750 14 3.84e-04 164 8 3 0.375 0.018 GO:0019083 BP 1 viral transcription 1 O60583,O60563,P50750 14 3.87e-04 129 8 3 0.375 0.023 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 O60583,O60563,P50750 14 4.28e-04 8 8 2 0.250 0.250 CORUM:2600 cor 1 BRD4 complex 1 O60563,P50750 14 4.66e-04 175 8 3 0.375 0.017 GO:0019080 BP 1 viral gene expression 1 O60583,O60563,P50750 14 4.93e-04 140 8 3 0.375 0.021 REAC:162587 rea 1 HIV Life Cycle 1 O60583,O60563,P50750 14 5.12e-04 492 8 4 0.500 0.008 GO:0034660 BP 1 ncRNA metabolic process 1 O60583,O00472,O60563,P50750 14 6.22e-04 193 8 3 0.375 0.016 GO:0044033 BP 1 multi-organism metabolic process 1 O60583,O60563,P50750 14 6.52e-04 31 8 2 0.250 0.065 REAC:167243 rea 1 Tat-mediated HIV elongation arrest and recovery 1 O60563,P50750 14 6.52e-04 31 8 2 0.250 0.065 REAC:167238 rea 1 Pausing and recovery of Tat-mediated HIV elongation 1 O60563,P50750 14 7.10e-04 37 8 2 0.250 0.054 GO:0050434 BP 1 positive regulation of viral transcription 1 O60563,P50750 14 7.49e-04 38 8 2 0.250 0.053 GO:0070063 MF 1 RNA polymerase binding 1 O60583,O60563 14 7.49e-04 38 8 2 0.250 0.053 GO:0006378 BP 1 mRNA polyadenylation 1 O60563,P50750 14 7.89e-04 39 8 2 0.250 0.051 GO:0043631 BP 1 RNA polyadenylation 1 O60563,P50750 14 8.55e-04 215 8 3 0.375 0.014 GO:0045787 BP 1 positive regulation of cell cycle 1 O60583,O60563,P50750 14 8.67e-04 216 8 3 0.375 0.014 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 O60583,O60563,P50750 14 9.46e-04 1865 8 6 0.750 0.003 GO:0006351 BP 1 transcription, DNA-templated 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 9.67e-04 1872 8 6 0.750 0.003 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 1.18e-03 13 8 2 0.250 0.154 CORUM:2639 cor 1 HES1 promoter-Notch enhancer complex 1 O60563,P50750 14 1.21e-03 4430 8 8 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 1.26e-03 43 8 2 0.250 0.047 REAC:167246 rea 1 Tat-mediated elongation of the HIV-1 transcript 1 O60563,P50750 14 1.26e-03 43 8 2 0.250 0.047 REAC:167169 rea 1 HIV Transcription Elongation 1 O60563,P50750 14 1.26e-03 43 8 2 0.250 0.047 REAC:167200 rea 1 Formation of HIV-1 elongation complex containing HIV-1 Tat 1 O60563,P50750 14 1.33e-03 1980 8 6 0.750 0.003 GO:0032774 BP 1 RNA biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 1.35e-03 51 8 2 0.250 0.039 GO:0046782 BP 1 regulation of viral transcription 1 O60563,P50750 14 1.78e-03 1 8 1 0.125 1.000 GO:1903837 BP 1 regulation of mRNA 3'-UTR binding 1 P50750 14 1.78e-03 1 8 1 0.125 1.000 GO:1903839 BP 1 positive regulation of mRNA 3'-UTR binding 1 P50750 14 1.82e-03 219 8 3 0.375 0.014 REAC:162906 rea 1 HIV Infection 1 O60583,O60563,P50750 14 2.00e-03 62 8 2 0.250 0.032 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 O60583,O60563 14 2.00e-03 62 8 2 0.250 0.032 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 O60583,O60563 14 2.54e-03 70 8 2 0.250 0.029 GO:0050684 BP 1 regulation of mRNA processing 1 O60563,P50750 14 2.85e-03 2267 8 6 0.750 0.003 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 2.97e-03 329 8 3 0.375 0.009 GO:0004674 MF 1 protein serine/threonine kinase activity 1 O60583,O60563,P50750 14 3.13e-03 335 8 3 0.375 0.009 GO:0008134 MF 1 transcription factor binding 1 O60583,O60563,P50750 14 3.13e-03 2305 8 6 0.750 0.003 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.16e-03 78 8 2 0.250 0.026 GO:1903902 BP 1 positive regulation of viral life cycle 1 O60563,P50750 14 3.17e-03 2310 8 6 0.750 0.003 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.29e-03 341 8 3 0.375 0.009 GO:0019058 BP 1 viral life cycle 1 O60583,O60563,P50750 14 3.32e-03 349 8 3 0.375 0.009 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 O60583,O60563,P50750 14 3.55e-03 2 8 1 0.125 0.500 GO:1905216 BP 1 positive regulation of RNA binding 1 P50750 14 3.55e-03 2 8 1 0.125 0.500 GO:1902415 BP 1 regulation of mRNA binding 1 P50750 14 3.55e-03 2 8 1 0.125 0.500 GO:0019085 BP 1 early viral transcription 1 O60583 14 3.55e-03 2 8 1 0.125 0.500 GO:1902416 BP 1 positive regulation of mRNA binding 1 P50750 14 3.57e-03 83 8 2 0.250 0.024 GO:0031124 BP 1 mRNA 3'-end processing 1 O60563,P50750 14 3.57e-03 83 8 2 0.250 0.024 GO:0048524 BP 1 positive regulation of viral process 1 O60563,P50750 14 3.69e-03 2374 8 6 0.750 0.003 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 4.19e-03 90 8 2 0.250 0.022 GO:1903311 BP 1 regulation of mRNA metabolic process 1 O60563,P50750 14 4.27e-03 373 8 3 0.375 0.008 GO:0016032 BP 1 viral process 1 O60583,O60563,P50750 14 4.33e-03 375 8 3 0.375 0.008 GO:0044764 BP 1 multi-organism cellular process 1 O60583,O60563,P50750 14 4.66e-03 95 8 2 0.250 0.021 GO:0043902 BP 1 positive regulation of multi-organism process 1 O60563,P50750 14 4.71e-03 386 8 3 0.375 0.008 GO:0044419 BP 1 interspecies interaction between organisms 1 O60583,O60563,P50750 14 4.71e-03 386 8 3 0.375 0.008 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 O60583,O60563,P50750 14 5.33e-03 3 8 1 0.125 0.333 GO:2000096 BP 1 positive regulation of Wnt signaling pathway, planar cell polarity pathway 1 P42568 14 5.33e-03 3 8 1 0.125 0.333 GO:1905214 BP 1 regulation of RNA binding 1 P50750 14 5.94e-03 114 8 2 0.250 0.018 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 O60583,P50750 14 5.96e-03 331 8 3 0.375 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 O60583,O60563,P50750 14 6.12e-03 109 8 2 0.250 0.018 GO:0031123 BP 1 RNA 3'-end processing 1 O60563,P50750 14 6.42e-03 1663 8 5 0.625 0.003 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 Q9UHB7,O60583,O00472,P50750,P42568 14 6.45e-03 112 8 2 0.250 0.018 GO:0019887 MF 1 protein kinase regulator activity 1 O60583,O60563 14 6.47e-03 2627 8 6 0.750 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 6.76e-03 346 8 3 0.375 0.009 REAC:5663205 rea 1 Infectious disease 1 O60583,O60563,P50750 14 7.10e-03 4 8 1 0.125 0.250 GO:2001168 BP 1 positive regulation of histone H2B ubiquitination 1 P50750 14 7.10e-03 4 8 1 0.125 0.250 GO:0019086 BP 1 late viral transcription 1 O60583 14 7.10e-03 4 8 1 0.125 0.250 GO:2000095 BP 1 regulation of Wnt signaling pathway, planar cell polarity pathway 1 P42568 14 7.10e-03 4 8 1 0.125 0.250 GO:2001166 BP 1 regulation of histone H2B ubiquitination 1 P50750 14 7.63e-03 2707 8 6 0.750 0.002 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 7.74e-03 459 8 3 0.375 0.007 GO:0001934 BP 1 positive regulation of protein phosphorylation 1 O60583,O60563,P50750 14 7.89e-03 124 8 2 0.250 0.016 GO:0019207 MF 1 kinase regulator activity 1 O60583,O60563 14 8.38e-03 472 8 3 0.375 0.006 GO:0004672 MF 1 protein kinase activity 1 O60583,O60563,P50750 14 8.39e-03 136 8 2 0.250 0.015 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 O60583,P50750 14 8.66e-03 2770 8 6 0.750 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 8.88e-03 5 8 1 0.125 0.200 GO:0033129 BP 1 positive regulation of histone phosphorylation 1 P50750 14 8.88e-03 5 8 1 0.125 0.200 GO:0033184 BP 1 positive regulation of histone ubiquitination 1 P50750 14 8.91e-03 3 8 1 0.125 0.333 HP:0100874 hp 1 Thick hair 1 Q9UHB7 14 9.00e-03 484 8 3 0.375 0.006 GO:0042327 BP 1 positive regulation of phosphorylation 1 O60583,O60563,P50750 14 9.18e-03 134 8 2 0.250 0.015 GO:1903900 BP 1 regulation of viral life cycle 1 O60563,P50750 14 9.76e-03 509 8 3 0.375 0.006 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 Q9UHB7,O60583,P50750 14 1.01e-02 2 8 1 0.125 0.500 CORUM:3229 cor 1 Heterodimer complex (CDK9, IL6ST) 1 P50750 14 1.01e-02 2 8 1 0.125 0.500 CORUM:1083 cor 1 P-TEFb.4 complex 1 P50750 14 1.03e-02 5787 8 8 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 1.03e-02 125 8 2 0.250 0.016 REAC:162909 rea 1 Host Interactions of HIV factors 1 O60563,P50750 14 1.05e-02 2869 8 6 0.750 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 1.06e-02 144 8 2 0.250 0.014 GO:0050792 BP 1 regulation of viral process 1 O60563,P50750 14 1.06e-02 6 8 1 0.125 0.167 GO:2000052 BP 1 positive regulation of non-canonical Wnt signaling pathway 1 P42568 14 1.08e-02 516 8 3 0.375 0.006 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 O60583,O60563,P50750 14 1.16e-02 529 8 3 0.375 0.006 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 O60583,O60563,P50750 14 1.16e-02 529 8 3 0.375 0.006 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 O60583,O60563,P50750 14 1.16e-02 5877 8 8 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 1.19e-02 153 8 2 0.250 0.013 GO:0043903 BP 1 regulation of symbiosis, encompassing mutualism through parasitism 1 O60563,P50750 14 1.37e-02 3013 8 6 0.750 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 1.38e-02 165 8 2 0.250 0.012 GO:0071902 BP 1 positive regulation of protein serine/threonine kinase activity 1 O60583,O60563 14 1.42e-02 8 8 1 0.125 0.125 GO:0033127 BP 1 regulation of histone phosphorylation 1 P50750 14 1.45e-02 169 8 2 0.250 0.012 GO:0043900 BP 1 regulation of multi-organism process 1 O60563,P50750 14 1.49e-02 3058 8 6 0.750 0.002 GO:0010467 BP 1 gene expression 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 1.49e-02 578 8 3 0.375 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 O60583,O60563,P50750 14 1.60e-02 9 8 1 0.125 0.111 GO:0033182 BP 1 regulation of histone ubiquitination 1 P50750 14 1.67e-02 616 8 3 0.375 0.005 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 O60583,O60563,P50750 14 1.77e-02 10 8 1 0.125 0.100 GO:0033523 BP 1 histone H2B ubiquitination 1 P50750 14 1.77e-02 10 8 1 0.125 0.100 GO:2000050 BP 1 regulation of non-canonical Wnt signaling pathway 1 P42568 14 1.78e-02 631 8 3 0.375 0.005 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 O60583,O60563,P50750 14 1.84e-02 624 8 3 0.375 0.005 GO:1990234 CC 1 transferase complex 1 O60583,O60563,P50750 14 1.89e-02 630 8 3 0.375 0.005 GO:0016301 MF 1 kinase activity 1 O60583,O60563,P50750 14 1.94e-02 4407 8 7 0.875 0.002 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568 14 1.95e-02 652 8 3 0.375 0.005 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q9UHB7,O60583,P50750 14 2.07e-02 650 8 3 0.375 0.005 GO:0031401 BP 1 positive regulation of protein modification process 1 O60583,O60563,P50750 14 2.07e-02 650 8 3 0.375 0.005 GO:0051704 BP 1 multi-organism process 1 O60583,O60563,P50750 14 2.07e-02 7 8 1 0.125 0.143 HP:0011951 hp 1 Aspiration pneumonia 1 Q9UHB7 14 2.08e-02 217 8 2 0.250 0.009 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 O60563,P50750 14 2.15e-02 221 8 2 0.250 0.009 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 O60583,P50750 14 2.21e-02 682 8 3 0.375 0.004 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 Q9UHB7,O60583,P50750 14 2.30e-02 13 8 1 0.125 0.077 GO:0071157 BP 1 negative regulation of cell cycle arrest 1 P50750 14 2.30e-02 13 8 1 0.125 0.077 GO:0043923 BP 1 positive regulation by host of viral transcription 1 O60563 14 2.33e-02 679 8 3 0.375 0.004 GO:0051726 BP 1 regulation of cell cycle 1 O60583,O60563,P50750 14 2.48e-02 14 8 1 0.125 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 P50750 14 2.48e-02 14 8 1 0.125 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 P50750 14 2.52e-02 5 8 1 0.125 0.200 CORUM:1191 cor 1 RNA pol II containing coactivator complex Tat-SF 1 P50750 14 2.54e-02 700 8 3 0.375 0.004 GO:0001932 BP 1 regulation of protein phosphorylation 1 O60583,O60563,P50750 14 2.58e-02 363 8 2 0.250 0.006 MI:hsa-miR-504 mi 1 MI:hsa-miR-504 1 Q9UHB7,Q03111 14 2.60e-02 3328 8 6 0.750 0.002 HPA:004010_01 hpa 1 breast; adipocytes[Uncertain,Low] 1 Q9UHB7,O60583,O00472,O60563,P50750,P42568 14 2.66e-02 15 8 1 0.125 0.067 GO:0008353 MF 1 RNA polymerase II carboxy-terminal domain kinase activity 1 P50750 14 2.67e-02 2286 8 5 0.625 0.002 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 O60583,O00472,O60563,P50750,P42568 14 2.81e-02 3443 8 6 0.750 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 2.83e-02 16 8 1 0.125 0.062 GO:0035327 CC 1 transcriptionally active chromatin 1 Q9UHB7 14 2.85e-02 240 8 2 0.250 0.008 GO:0003682 MF 1 chromatin binding 1 O60583,P50750 14 2.97e-02 741 8 3 0.375 0.004 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 O60583,O60563,P50750 14 2.97e-02 741 8 3 0.375 0.004 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 O60583,O60563,P50750 14 3.01e-02 17 8 1 0.125 0.059 GO:0052312 BP 1 modulation of transcription in other organism involved in symbiotic interaction 1 O60563 14 3.01e-02 17 8 1 0.125 0.059 GO:0052472 BP 1 modulation by host of symbiont transcription 1 O60563 14 3.01e-02 17 8 1 0.125 0.059 GO:0043921 BP 1 modulation by host of viral transcription 1 O60563 14 3.05e-02 265 8 2 0.250 0.008 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 O60583,P50750 14 3.05e-02 265 8 2 0.250 0.008 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 O60583,P50750 14 3.06e-02 3499 8 6 0.750 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.13e-02 755 8 3 0.375 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 O60583,O60563,P50750 14 3.13e-02 252 8 2 0.250 0.008 GO:0045860 BP 1 positive regulation of protein kinase activity 1 O60583,O60563 14 3.14e-02 775 8 3 0.375 0.004 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 O60583,O60563,P50750 14 3.18e-02 760 8 3 0.375 0.004 GO:0042325 BP 1 regulation of phosphorylation 1 O60583,O60563,P50750 14 3.20e-02 6671 8 8 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568,P51825 14 3.21e-02 762 8 3 0.375 0.004 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 O60583,O60563,P50750 14 3.33e-02 3554 8 6 0.750 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.36e-02 3561 8 6 0.750 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.38e-02 420 8 2 0.250 0.005 MI:hsa-miR-651 mi 1 MI:hsa-miR-651 1 Q9UHB7,P42568 14 3.40e-02 798 8 3 0.375 0.004 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 O60583,O60563,P50750 14 3.40e-02 3569 8 6 0.750 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.45e-02 802 8 3 0.375 0.004 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 O60583,O00472,P50750 14 3.47e-02 804 8 3 0.375 0.004 HPA:019010_03 hpa 1 kidney; cells in glomeruli[Uncertain,High] 1 O60583,O60563,P50750 14 3.49e-02 628 8 3 0.375 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 O60583,O60563,P50750 14 3.53e-02 20 8 1 0.125 0.050 GO:0016572 BP 1 histone phosphorylation 1 P50750 14 3.55e-02 791 8 3 0.375 0.004 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 O60583,O60563,P50750 14 3.65e-02 273 8 2 0.250 0.007 GO:0033674 BP 1 positive regulation of kinase activity 1 O60583,O60563 14 3.67e-02 3620 8 6 0.750 0.002 GO:0009058 BP 1 biosynthetic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 3.68e-02 4872 8 7 0.875 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750,P42568 14 3.72e-02 276 8 2 0.250 0.007 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 O60583,O60563 14 3.79e-02 447 8 2 0.250 0.004 MI:hsa-miR-216b mi 1 MI:hsa-miR-216b 1 Q9UHB7,O60583 14 3.86e-02 836 8 3 0.375 0.004 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 O60583,O60563,P50750 14 3.89e-02 1578 8 4 0.500 0.003 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 O60583,O00472,O60563,P50750 14 3.92e-02 455 8 2 0.250 0.004 MI:mmu-miR-714 mi 1 MI:mmu-miR-714 1 Q9UHB7,Q03111 14 4.00e-02 3681 8 6 0.750 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q9UHB7,O60583,O00472,O60563,Q03111,P50750 14 4.08e-02 832 8 3 0.375 0.004 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 O60583,O60563,P50750 14 4.11e-02 467 8 2 0.250 0.004 MI:hsa-miR-891a mi 1 MI:hsa-miR-891a 1 O60583,P42568 14 4.13e-02 468 8 2 0.250 0.004 MI:hsa-miR-220 mi 1 MI:hsa-miR-220 1 Q9UHB7,O00472 14 4.19e-02 472 8 2 0.250 0.004 MI:hsa-miR-574-3p mi 1 MI:hsa-miR-574-3p 1 O60583,O00472 14 4.24e-02 24 8 1 0.125 0.042 GO:0031297 BP 1 replication fork processing 1 P50750 14 4.25e-02 867 8 3 0.375 0.003 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 O60583,O00472,P50750 14 4.28e-02 317 8 2 0.250 0.006 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 O60583,P50750 14 4.32e-02 850 8 3 0.375 0.004 GO:0044093 BP 1 positive regulation of molecular function 1 O60583,O60563,P50750 14 4.35e-02 874 8 3 0.375 0.003 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 O60583,O60563,P50750 14 4.56e-02 494 8 2 0.250 0.004 MI:hsa-miR-139-5p mi 1 MI:hsa-miR-139-5p 1 Q9UHB7,O60583 14 4.68e-02 501 8 2 0.250 0.004 MI:hsa-miR-142-3p mi 1 MI:hsa-miR-142-3p 1 Q9UHB7,O60583 14 4.69e-02 333 8 2 0.250 0.006 HPA:020010_13 hpa 1 lateral ventricle; glial cells[Supportive,High] 1 O60583,P50750 14 4.73e-02 902 8 3 0.375 0.003 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 O60583,O60563,P50750 14 4.75e-02 880 8 3 0.375 0.003 GO:0051247 BP 1 positive regulation of protein metabolic process 1 O60583,O60563,P50750 14 4.76e-02 27 8 1 0.125 0.037 GO:0045005 BP 1 DNA-dependent DNA replication maintenance of fidelity 1 P50750 14 4.79e-02 906 8 3 0.375 0.003 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 O60583,O60563,P50750 14 4.82e-02 885 8 3 0.375 0.003 GO:0019220 BP 1 regulation of phosphate metabolic process 1 O60583,O60563,P50750 14 4.83e-02 338 8 2 0.250 0.006 HPA:041010_13 hpa 1 spleen; cells in red pulp[Supportive,High] 1 O60583,P50750 14 4.91e-02 341 8 2 0.250 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 O60583,P50750 14 4.93e-02 516 8 2 0.250 0.004 MI:hsa-miR-199a-3p mi 1 MI:hsa-miR-199a-3p 1 Q9UHB7,O60583 14 4.97e-02 919 8 3 0.375 0.003 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 O60583,O60563,P50750 14 4.98e-02 896 8 3 0.375 0.003 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 O60583,O60563,P50750 14 5.00e-02 720 8 3 0.375 0.004 REAC:1643685 rea 1 Disease 1 O60583,O60563,P50750 14 5.00e-02 115 8 6 0.750 0.052 KEGG:05202 keg 1 Transcriptional misregulation in cancer 1 O60583,O60563,Q03111,P50750,P42568,P51825 14 5.00e-02 266 8 3 0.375 0.011 TF:M04196_0 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 0 1 Q9UHB7,O60583,O60563 14 5.00e-02 921 8 3 0.375 0.003 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 O60583,O60563,P50750 14 5.00e-02 10 8 1 0.125 0.100 CORUM:1239 cor 1 EBAFb complex 1 Q03111 14 5.00e-02 266 8 3 0.375 0.011 TF:M04196_1 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 1 1 Q9UHB7,O60583,O60563 14 5.00e-02 10 8 1 0.125 0.100 CORUM:1252 cor 1 EBAFa complex 1 Q03111 14 5.00e-02 897 8 3 0.375 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 O60583,O60563,P50750 14 5.00e-02 1 8 1 0.125 1.000 OMIM:616368 omi 1 CHOPS SYNDROME; CHOPS;;COGNITIVE IMPAIRMENT, COARSE FACIES, HEART DEFECTS, OBESITY, PULMONARYINVOLVEMENT, SHORT STATURE, AND SKELETAL DYSPLASIA 1 Q9UHB7 15 1.79e-06 11 2 2 1.000 0.182 GO:0051974 BP 1 negative regulation of telomerase activity 1 P54274,Q96BK5 15 1.79e-06 11 2 2 1.000 0.182 GO:0032211 BP 1 negative regulation of telomere maintenance via telomerase 1 P54274,Q96BK5 15 2.96e-06 14 2 2 1.000 0.143 GO:1904357 BP 1 negative regulation of telomere maintenance via telomere lengthening 1 P54274,Q96BK5 15 7.52e-06 22 2 2 1.000 0.091 GO:2000279 BP 1 negative regulation of DNA biosynthetic process 1 P54274,Q96BK5 15 8.98e-06 24 2 2 1.000 0.083 GO:0032205 BP 1 negative regulation of telomere maintenance 1 P54274,Q96BK5 15 1.06e-05 26 2 2 1.000 0.077 GO:0070198 BP 1 protein localization to chromosome, telomeric region 1 P54274,Q96BK5 15 1.83e-05 34 2 2 1.000 0.059 GO:0051972 BP 1 regulation of telomerase activity 1 P54274,Q96BK5 15 2.54e-05 40 2 2 1.000 0.050 GO:0032210 BP 1 regulation of telomere maintenance via telomerase 1 P54274,Q96BK5 15 3.08e-05 44 2 2 1.000 0.045 GO:1904356 BP 1 regulation of telomere maintenance via telomere lengthening 1 P54274,Q96BK5 15 4.15e-05 51 2 2 1.000 0.039 GO:0007004 BP 1 telomere maintenance via telomerase 1 P54274,Q96BK5 15 4.31e-05 52 2 2 1.000 0.038 GO:2001251 BP 1 negative regulation of chromosome organization 1 P54274,Q96BK5 15 4.31e-05 52 2 2 1.000 0.038 GO:0006278 BP 1 RNA-dependent DNA biosynthetic process 1 P54274,Q96BK5 15 4.83e-05 55 2 2 1.000 0.036 GO:0034502 BP 1 protein localization to chromosome 1 P54274,Q96BK5 15 5.01e-05 56 2 2 1.000 0.036 GO:0010833 BP 1 telomere maintenance via telomere lengthening 1 P54274,Q96BK5 15 5.57e-05 59 2 2 1.000 0.034 GO:0032204 BP 1 regulation of telomere maintenance 1 P54274,Q96BK5 15 7.63e-05 69 2 2 1.000 0.029 GO:2000278 BP 1 regulation of DNA biosynthetic process 1 P54274,Q96BK5 15 1.03e-04 80 2 2 1.000 0.025 GO:0051053 BP 1 negative regulation of DNA metabolic process 1 P54274,Q96BK5 15 1.27e-04 89 2 2 1.000 0.022 GO:0032845 BP 1 negative regulation of homeostatic process 1 P54274,Q96BK5 15 1.61e-04 100 2 2 1.000 0.020 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 P54274,Q96BK5 15 1.92e-04 109 2 2 1.000 0.018 GO:0000723 BP 1 telomere maintenance 1 P54274,Q96BK5 15 1.95e-04 110 2 2 1.000 0.018 GO:0032200 BP 1 telomere organization 1 P54274,Q96BK5 15 2.02e-04 112 2 2 1.000 0.018 GO:0000781 CC 1 chromosome, telomeric region 1 P54274,Q96BK5 15 2.21e-04 117 2 2 1.000 0.017 GO:0033044 BP 1 regulation of chromosome organization 1 P54274,Q96BK5 15 3.17e-04 140 2 2 1.000 0.014 GO:0071897 BP 1 DNA biosynthetic process 1 P54274,Q96BK5 15 3.75e-04 1 2 1 0.500 1.000 GO:1904913 BP 1 regulation of establishment of macromolecular complex localization to telomere 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904792 BP 1 positive regulation of telosome assembly 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:0071573 BP 1 telosome assembly 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904910 BP 1 regulation of establishment of RNA localization to telomere 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904850 BP 1 negative regulation of establishment of protein localization to telomere 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904790 BP 1 regulation of telosome assembly 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904914 BP 1 negative regulation of establishment of macromolecular complex localization to telomere 1 P54274 15 3.75e-04 1 2 1 0.500 1.000 GO:1904911 BP 1 negative regulation of establishment of RNA localization to telomere 1 P54274 15 4.73e-04 171 2 2 1.000 0.012 GO:0010639 BP 1 negative regulation of organelle organization 1 P54274,Q96BK5 15 6.41e-04 199 2 2 1.000 0.010 GO:0060249 BP 1 anatomical structure homeostasis 1 P54274,Q96BK5 15 7.51e-04 2 2 1 0.500 0.500 GO:0032213 BP 1 regulation of telomere maintenance via semi-conservative replication 1 P54274 15 7.51e-04 2 2 1 0.500 0.500 GO:0032214 BP 1 negative regulation of telomere maintenance via semi-conservative replication 1 P54274 15 7.51e-04 2 2 1 0.500 0.500 GO:1904815 BP 1 negative regulation of protein localization to chromosome, telomeric region 1 P54274 15 7.51e-04 2 2 1 0.500 0.500 GO:1904744 BP 1 positive regulation of telomeric DNA binding 1 Q96BK5 15 8.05e-04 223 2 2 1.000 0.009 GO:0032844 BP 1 regulation of homeostatic process 1 P54274,Q96BK5 15 8.57e-04 230 2 2 1.000 0.009 GO:0098687 CC 1 chromosomal region 1 P54274,Q96BK5 15 8.64e-04 231 2 2 1.000 0.009 GO:0051348 BP 1 negative regulation of transferase activity 1 P54274,Q96BK5 15 9.02e-04 236 2 2 1.000 0.008 GO:0051052 BP 1 regulation of DNA metabolic process 1 P54274,Q96BK5 15 1.13e-03 3 2 1 0.500 0.333 GO:1902576 BP 1 negative regulation of nuclear cell cycle DNA replication 1 P54274 15 1.13e-03 3 2 1 0.500 0.333 GO:0097695 BP 1 establishment of macromolecular complex localization to telomere 1 P54274 15 1.13e-03 3 2 1 0.500 0.333 GO:0031627 BP 1 telomeric loop formation 1 P54274 15 1.13e-03 3 2 1 0.500 0.333 GO:1904749 BP 1 regulation of protein localization to nucleolus 1 Q96BK5 15 1.13e-03 3 2 1 0.500 0.333 GO:0097694 BP 1 establishment of RNA localization to telomere 1 P54274 15 1.13e-03 3 2 1 0.500 0.333 GO:1904751 BP 1 positive regulation of protein localization to nucleolus 1 Q96BK5 15 1.13e-03 3 2 1 0.500 0.333 GO:1904742 BP 1 regulation of telomeric DNA binding 1 Q96BK5 15 1.50e-03 4 2 1 0.500 0.250 GO:1902570 BP 1 protein localization to nucleolus 1 Q96BK5 15 2.07e-03 357 2 2 1.000 0.006 GO:0044454 CC 1 nuclear chromosome part 1 P54274,Q96BK5 15 2.09e-03 359 2 2 1.000 0.006 GO:0051129 BP 1 negative regulation of cellular component organization 1 P54274,Q96BK5 15 2.20e-03 368 2 2 1.000 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 P54274,Q96BK5 15 2.25e-03 6 2 1 0.500 0.167 GO:0032201 BP 1 telomere maintenance via semi-conservative replication 1 P54274 15 2.25e-03 6 2 1 0.500 0.167 GO:0070187 CC 1 telosome 1 P54274 15 2.38e-03 383 2 2 1.000 0.005 GO:0000228 CC 1 nuclear chromosome 1 P54274,Q96BK5 15 2.63e-03 7 2 1 0.500 0.143 GO:0003964 MF 1 RNA-directed DNA polymerase activity 1 P54274 15 2.63e-03 7 2 1 0.500 0.143 GO:0010521 MF 1 telomerase inhibitor activity 1 Q96BK5 15 2.63e-03 7 2 1 0.500 0.143 GO:0098505 MF 1 G-rich strand telomeric DNA binding 1 P54274 15 2.63e-03 7 2 1 0.500 0.143 GO:0003720 MF 1 telomerase activity 1 P54274 15 2.85e-03 419 2 2 1.000 0.005 GO:0043086 BP 1 negative regulation of catalytic activity 1 P54274,Q96BK5 15 3.00e-03 8 2 1 0.500 0.125 GO:0003691 MF 1 double-stranded telomeric DNA binding 1 P54274 15 3.23e-03 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 P54274,Q96BK5 15 3.38e-03 9 2 1 0.500 0.111 GO:0033262 BP 1 regulation of nuclear cell cycle DNA replication 1 P54274 15 3.75e-03 10 2 1 0.500 0.100 GO:0070202 BP 1 regulation of establishment of protein localization to chromosome 1 P54274 15 3.75e-03 10 2 1 0.500 0.100 GO:0098847 MF 1 sequence-specific single stranded DNA binding 1 P54274 15 3.75e-03 10 2 1 0.500 0.100 GO:0008301 MF 1 DNA binding, bending 1 P54274 15 3.75e-03 10 2 1 0.500 0.100 GO:0070203 BP 1 regulation of establishment of protein localization to telomere 1 P54274 15 3.75e-03 10 2 1 0.500 0.100 GO:0043047 MF 1 single-stranded telomeric DNA binding 1 P54274 15 4.22e-03 510 2 2 1.000 0.004 GO:0060341 BP 1 regulation of cellular localization 1 P54274,Q96BK5 15 4.50e-03 12 2 1 0.500 0.083 GO:0000783 CC 1 nuclear telomere cap complex 1 P54274 15 4.50e-03 12 2 1 0.500 0.083 GO:0000782 CC 1 telomere cap complex 1 P54274 15 4.81e-03 544 2 2 1.000 0.004 GO:0032880 BP 1 regulation of protein localization 1 P54274,Q96BK5 15 4.88e-03 13 2 1 0.500 0.077 GO:1904814 BP 1 regulation of protein localization to chromosome, telomeric region 1 P54274 15 5.18e-03 565 2 2 1.000 0.004 GO:0044427 CC 1 chromosomal part 1 P54274,Q96BK5 15 5.28e-03 570 2 2 1.000 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 P54274,Q96BK5 15 5.41e-03 577 2 2 1.000 0.003 GO:0051338 BP 1 regulation of transferase activity 1 P54274,Q96BK5 15 5.63e-03 15 2 1 0.500 0.067 GO:0070200 BP 1 establishment of protein localization to telomere 1 P54274 15 5.63e-03 15 2 1 0.500 0.067 GO:2000104 BP 1 negative regulation of DNA-dependent DNA replication 1 P54274 15 6.00e-03 16 2 1 0.500 0.062 GO:0070034 MF 1 telomerase RNA binding 1 Q96BK5 15 6.02e-03 609 2 2 1.000 0.003 GO:0005694 CC 1 chromosome 1 P54274,Q96BK5 15 6.76e-03 645 2 2 1.000 0.003 GO:0005730 CC 1 nucleolus 1 P54274,Q96BK5 15 7.01e-03 657 2 2 1.000 0.003 GO:0033365 BP 1 protein localization to organelle 1 P54274,Q96BK5 15 7.15e-03 1 2 1 0.500 1.000 CORUM:2219 cor 1 TERF1 homodimer complex 1 P54274 15 7.29e-03 670 2 2 1.000 0.003 GO:0006259 BP 1 DNA metabolic process 1 P54274,Q96BK5 15 7.50e-03 20 2 1 0.500 0.050 GO:0043388 BP 1 positive regulation of DNA binding 1 Q96BK5 15 7.67e-03 21 2 1 0.500 0.048 REAC:171306 rea 1 Packaging Of Telomere Ends 1 P54274 15 7.87e-03 21 2 1 0.500 0.048 GO:0033260 BP 1 nuclear DNA replication 1 P54274 15 8.12e-03 707 2 2 1.000 0.003 GO:0033043 BP 1 regulation of organelle organization 1 P54274,Q96BK5 15 8.25e-03 22 2 1 0.500 0.045 GO:0070199 BP 1 establishment of protein localization to chromosome 1 P54274 15 9.21e-03 753 2 2 1.000 0.003 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 P54274,Q96BK5 15 9.51e-03 765 2 2 1.000 0.003 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 P54274,Q96BK5 15 9.75e-03 26 2 1 0.500 0.038 GO:0034061 MF 1 DNA polymerase activity 1 P54274 15 9.96e-03 783 2 2 1.000 0.003 GO:0042592 BP 1 homeostatic process 1 P54274,Q96BK5 15 1.01e-02 27 2 1 0.500 0.037 GO:0008156 BP 1 negative regulation of DNA replication 1 P54274 15 1.02e-02 794 2 2 1.000 0.003 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 P54274,Q96BK5 15 1.09e-02 29 2 1 0.500 0.034 GO:0044786 BP 1 cell cycle DNA replication 1 P54274 15 1.10e-02 822 2 2 1.000 0.002 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 P54274,Q96BK5 15 1.12e-02 30 2 1 0.500 0.033 GO:0042162 MF 1 telomeric DNA binding 1 P54274 15 1.13e-02 834 2 2 1.000 0.002 GO:0009890 BP 1 negative regulation of biosynthetic process 1 P54274,Q96BK5 15 1.18e-02 852 2 2 1.000 0.002 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 P54274,Q96BK5 15 1.20e-02 32 2 1 0.500 0.031 GO:0016233 BP 1 telomere capping 1 P54274 15 1.31e-02 35 2 1 0.500 0.029 GO:0090329 BP 1 regulation of DNA-dependent DNA replication 1 P54274 15 1.47e-02 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 P54274,Q96BK5 15 1.54e-02 41 2 1 0.500 0.024 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q96BK5 15 1.57e-02 43 2 1 0.500 0.023 REAC:1221632 rea 1 Meiotic synapsis 1 P54274 15 1.75e-02 48 2 1 0.500 0.021 REAC:2559586 rea 1 DNA Damage/Telomere Stress Induced Senescence 1 P54274 15 1.80e-02 48 2 1 0.500 0.021 GO:0051310 BP 1 metaphase plate congression 1 Q96BK5 15 1.80e-02 48 2 1 0.500 0.021 GO:0051101 BP 1 regulation of DNA binding 1 Q96BK5 15 1.86e-02 51 2 1 0.500 0.020 REAC:157579 rea 1 Telomere Maintenance 1 P54274 15 1.86e-02 1071 2 2 1.000 0.002 GO:0050790 BP 1 regulation of catalytic activity 1 P54274,Q96BK5 15 2.01e-02 1111 2 2 1.000 0.002 GO:0034613 BP 1 cellular protein localization 1 P54274,Q96BK5 15 2.04e-02 1121 2 2 1.000 0.002 GO:0070727 BP 1 cellular macromolecule localization 1 P54274,Q96BK5 15 2.06e-02 55 2 1 0.500 0.018 GO:0051303 BP 1 establishment of chromosome localization 1 Q96BK5 15 2.07e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 P54274,Q96BK5 15 2.10e-02 56 2 1 0.500 0.018 GO:0050000 BP 1 chromosome localization 1 Q96BK5 15 2.14e-02 3 2 1 0.500 0.333 CORUM:1219 cor 1 Tankyrin 1-tankyrin 2-TRF1 complex 1 P54274 15 2.14e-02 3 2 1 0.500 0.333 CORUM:1202 cor 1 TRF1 telomere length regulation complex 1 P54274 15 2.22e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 P54274,Q96BK5 15 2.43e-02 65 2 1 0.500 0.015 GO:0051099 BP 1 positive regulation of binding 1 Q96BK5 15 2.48e-02 68 2 1 0.500 0.015 REAC:1500620 rea 1 Meiosis 1 P54274 15 2.62e-02 70 2 1 0.500 0.014 GO:0003697 MF 1 single-stranded DNA binding 1 P54274 15 2.69e-02 72 2 1 0.500 0.014 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 Q96BK5 15 2.73e-02 73 2 1 0.500 0.014 GO:0032993 CC 1 protein-DNA complex 1 P54274 15 2.79e-02 1310 2 2 1.000 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 P54274,Q96BK5 15 2.82e-02 1317 2 2 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 P54274,Q96BK5 15 2.84e-02 78 2 1 0.500 0.013 REAC:73886 rea 1 Chromosome Maintenance 1 P54274 15 2.84e-02 76 2 1 0.500 0.013 GO:0006275 BP 1 regulation of DNA replication 1 P54274 15 2.86e-02 4 2 1 0.500 0.250 CORUM:1201 cor 1 TRF1-TIN2 complex 1 P54274 15 2.92e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 P54274,Q96BK5 15 3.13e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 P54274,Q96BK5 15 3.15e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 P54274,Q96BK5 15 3.22e-02 86 2 1 0.500 0.012 GO:1903828 BP 1 negative regulation of cellular protein localization 1 P54274 15 3.30e-02 1424 2 2 1.000 0.001 GO:0009892 BP 1 negative regulation of metabolic process 1 P54274,Q96BK5 15 3.36e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 P54274,Q96BK5 15 3.40e-02 91 2 1 0.500 0.011 GO:0000776 CC 1 kinetochore 1 Q96BK5 15 3.51e-02 94 2 1 0.500 0.011 GO:0043130 MF 1 ubiquitin binding 1 P54274 15 3.92e-02 105 2 1 0.500 0.010 GO:0032182 MF 1 ubiquitin-like protein binding 1 P54274 15 3.92e-02 105 2 1 0.500 0.010 GO:0016779 MF 1 nucleotidyltransferase activity 1 P54274 15 4.03e-02 108 2 1 0.500 0.009 GO:0031397 BP 1 negative regulation of protein ubiquitination 1 Q96BK5 15 4.22e-02 113 2 1 0.500 0.009 GO:1903321 BP 1 negative regulation of protein modification by small protein conjugation or removal 1 Q96BK5 15 4.22e-02 113 2 1 0.500 0.009 GO:1904950 BP 1 negative regulation of establishment of protein localization 1 P54274 15 4.26e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 P54274,Q96BK5 15 4.29e-02 6 2 1 0.500 0.167 CORUM:138 cor 1 Telosome complex 1 P54274 15 4.29e-02 6 2 1 0.500 0.167 CORUM:1197 cor 1 TRF1-TIN2 complex 1 P54274 15 4.29e-02 6 2 1 0.500 0.167 CORUM:1206 cor 1 TRF-Rap1 complex I, 2MD 1 P54274 15 4.44e-02 119 2 1 0.500 0.008 GO:0006261 BP 1 DNA-dependent DNA replication 1 P54274 15 4.44e-02 119 2 1 0.500 0.008 GO:1900180 BP 1 regulation of protein localization to nucleus 1 Q96BK5 15 4.44e-02 119 2 1 0.500 0.008 GO:0000070 BP 1 mitotic sister chromatid segregation 1 Q96BK5 15 4.52e-02 121 2 1 0.500 0.008 GO:0000775 CC 1 chromosome, centromeric region 1 Q96BK5 15 4.78e-02 128 2 1 0.500 0.008 GO:0051236 BP 1 establishment of RNA localization 1 P54274 15 5.00e-02 138 2 1 0.500 0.007 REAC:2559583 rea 1 Cellular Senescence 1 P54274 15 5.00e-02 7 2 1 0.500 0.143 CORUM:1204 cor 1 Rap1 complex 1 P54274 15 5.00e-02 274 2 2 1.000 0.007 TF:M00622_1 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 1 1 P54274,Q96BK5 15 5.00e-02 394 2 2 1.000 0.005 MI:hsa-miR-595 mi 1 MI:hsa-miR-595 1 P54274,Q96BK5 16 2.14e-02 3 3 1 0.333 0.333 GO:0035563 BP 1 positive regulation of chromatin binding 1 Q6NT76 16 2.55e-02 1028 3 2 0.667 0.002 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 Q7Z6J8,Q9Y316 16 2.59e-02 322 3 2 0.667 0.006 MI:hsa-miR-24-2* mi 1 MI:hsa-miR-24-2* 1 Q7Z6J8,Q9Y316 16 3.48e-02 3524 3 3 1.000 0.001 HPA:038010_02 hpa 1 smooth muscle; smooth muscle cells[Uncertain,Medium] 1 Q7Z6J8,Q6NT76,Q9Y316 16 3.58e-02 379 3 2 0.667 0.005 MI:hsa-miR-30b* mi 1 MI:hsa-miR-30b* 1 Q7Z6J8,Q6NT76 16 4.08e-02 405 3 2 0.667 0.005 MI:hsa-miR-943 mi 1 MI:hsa-miR-943 1 Q7Z6J8,Q6NT76 16 4.29e-02 6 3 1 0.333 0.167 GO:0035561 BP 1 regulation of chromatin binding 1 Q6NT76 16 5.00e-02 11 3 1 0.333 0.091 REAC:6785631 rea 1 ERBB2 Regulates Cell Motility 1 Q9Y316 16 5.00e-02 449 3 2 0.667 0.004 MI:hsa-miR-888 mi 1 MI:hsa-miR-888 1 Q6NT76,Q9Y316 16 5.00e-02 3 3 1 0.333 0.333 CORUM:2528 cor 1 ERBB2-MEMO-SHC complex 1 Q9Y316 16 5.00e-02 7 3 1 0.333 0.143 GO:0003964 MF 1 RNA-directed DNA polymerase activity 1 Q6NT76 16 5.00e-02 7 3 1 0.333 0.143 GO:0003720 MF 1 telomerase activity 1 Q6NT76 16 5.00e-02 4 3 1 0.333 0.250 TF:M06934_0 tf 1 Factor: DUX1; motif: ATAATCTGATTAT; match class: 0 1 Q7Z6J8 16 5.00e-02 4 3 1 0.333 0.250 TF:M06974_0 tf 1 Factor: PRRX2; motif: WTAATCTGATTAT; match class: 0 1 Q7Z6J8 16 5.00e-02 4 3 1 0.333 0.250 TF:M06925_0 tf 1 Factor: DUXA; motif: ATAATCTGATTAT; match class: 0 1 Q7Z6J8 17 3.59e-03 1 3 1 0.333 1.000 OMIM:614700 omi 1 IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY; CVID8 1 P50851 17 3.59e-03 1 3 1 0.333 1.000 OMIM:610612 omi 1 LEBER CONGENITAL AMAUROSIS 12; LCA12 1 Q7Z3Z2 17 7.50e-03 2492 3 3 1.000 0.001 TF:M05347_0 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 7.76e-03 33 3 1 0.333 0.030 TF:M07307_1 tf 1 Factor: Sox18; motif: ACAAWGBSNNN; match class: 1 1 Q7Z3Z2 17 9.16e-03 39 3 1 0.333 0.026 TF:M03930_0 tf 1 Factor: ZIC1; motif: GACCCCCYGCTGTG; match class: 0 1 Q7Z3Z2 17 1.11e-02 792 3 2 0.667 0.003 TF:M07378_1 tf 1 Factor: cdx; motif: NNTTTATNN; match class: 1 1 Q8NFP9,P50851 17 1.11e-02 10 3 1 0.333 0.100 HP:0011734 hp 1 Central adrenal insufficiency 1 P50851 17 1.16e-02 808 3 2 0.667 0.002 TF:M00993_0 tf 1 Factor: Tal-1; motif: TCCAKCTGNY; match class: 0 1 Q8NFP9,P50851 17 1.22e-02 11 3 1 0.333 0.091 HP:0005263 hp 1 Gastritis 1 P50851 17 1.22e-02 11 3 1 0.333 0.091 HP:0001904 hp 1 Autoimmune neutropenia 1 P50851 17 1.34e-02 57 3 1 0.333 0.018 TF:M05912_0 tf 1 Factor: FLJ20557; motif: NGGKGYTAMASA; match class: 0 1 P50851 17 1.36e-02 58 3 1 0.333 0.017 TF:M03566_1 tf 1 Factor: SNA; motif: GCCACCTGNCNGYN; match class: 1 1 Q7Z3Z2 17 1.67e-02 15 3 1 0.333 0.067 HP:0002850 hp 1 IgM deficiency 1 P50851 17 1.67e-02 15 3 1 0.333 0.067 HP:0100723 hp 1 Gastrointestinal stroma tumor 1 P50851 17 1.78e-02 16 3 1 0.333 0.062 HP:0003296 hp 1 Hyperthreoninuria 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0030211 hp 1 Slow pupillary light response 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0003354 hp 1 Hyperthreoninemia 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0010900 hp 1 Abnormality of threonine metabolism 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0001116 hp 1 Macular coloboma 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0007695 hp 1 Abnormal pupillary light reflex 1 Q7Z3Z2 17 1.78e-02 16 3 1 0.333 0.062 HP:0001483 hp 1 Eye poking 1 Q7Z3Z2 17 2.00e-02 18 3 1 0.333 0.056 HP:0005435 hp 1 Impaired T cell function 1 P50851 17 2.01e-02 86 3 1 0.333 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 P50851 17 2.11e-02 19 3 1 0.333 0.053 HP:0010976 hp 1 B lymphocytopenia 1 P50851 17 2.11e-02 19 3 1 0.333 0.053 HP:0002720 hp 1 IgA deficiency 1 P50851 17 2.18e-02 93 3 1 0.333 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 P50851 17 2.22e-02 20 3 1 0.333 0.050 HP:0001890 hp 1 Autoimmune hemolytic anemia 1 P50851 17 2.22e-02 95 3 1 0.333 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 Q7Z3Z2 17 2.33e-02 21 3 1 0.333 0.048 HP:0008499 hp 1 High-grade hypermetropia 1 Q7Z3Z2 17 2.33e-02 21 3 1 0.333 0.048 HP:0100759 hp 1 Clubbing of fingers 1 P50851 17 2.33e-02 3635 3 3 1.000 0.001 TF:M00927_0 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 2.44e-02 22 3 1 0.333 0.045 HP:0010975 hp 1 Abnormality of B cell number 1 P50851 17 2.48e-02 106 3 1 0.333 0.009 TF:M06254_0 tf 1 Factor: znf267; motif: NGCWACTGGCGC; match class: 0 1 P50851 17 2.51e-02 7 3 1 0.333 0.143 OMIM:607594 omi 1 Common Variable Immunodeficiency 1 P50851 17 2.52e-02 108 3 1 0.333 0.009 TF:M07049_1 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 1 1 Q8NFP9 17 2.55e-02 23 3 1 0.333 0.043 HP:0006528 hp 1 Chronic lung disease 1 P50851 17 2.62e-02 112 3 1 0.333 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 Q7Z3Z2 17 2.71e-02 116 3 1 0.333 0.009 TF:M05880_0 tf 1 Factor: ZNF676; motif: NGGGTAGGGTGA; match class: 0 1 Q7Z3Z2 17 2.73e-02 3835 3 3 1.000 0.001 TF:M02909_0 tf 1 Factor: SOX4; motif: NNNNNAATTGTTNNNNN; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 2.99e-02 27 3 1 0.333 0.037 HP:0000480 hp 1 Retinal coloboma 1 Q7Z3Z2 17 3.09e-02 3995 3 3 1.000 0.001 TF:M00426_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 3.20e-02 29 3 1 0.333 0.034 HP:0002583 hp 1 Colitis 1 P50851 17 3.26e-02 140 3 1 0.333 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 P50851 17 3.31e-02 30 3 1 0.333 0.033 HP:0001581 hp 1 Recurrent skin infections 1 P50851 17 3.31e-02 30 3 1 0.333 0.033 HP:0001211 hp 1 Abnormality of the fingertips 1 P50851 17 3.42e-02 31 3 1 0.333 0.032 HP:0000979 hp 1 Purpura 1 P50851 17 3.42e-02 31 3 1 0.333 0.032 HP:0007686 hp 1 Abnormal pupillary function 1 Q7Z3Z2 17 3.45e-02 148 3 1 0.333 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 P50851 17 3.53e-02 32 3 1 0.333 0.031 HP:0010899 hp 1 Abnormality of aspartate family amino acid metabolism 1 Q7Z3Z2 17 3.53e-02 1437 3 2 0.667 0.001 TF:M01279_0 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 0 1 Q7Z3Z2,P50851 17 3.55e-02 1221 3 2 0.667 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q8NFP9,P50851 17 3.67e-02 4230 3 3 1.000 0.001 TF:M03867_0 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 3.72e-02 1476 3 2 0.667 0.001 TF:M02110_1 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 1 1 Q8NFP9,P50851 17 3.75e-02 34 3 1 0.333 0.029 HP:0004315 hp 1 IgG deficiency 1 P50851 17 3.75e-02 34 3 1 0.333 0.029 HP:0002028 hp 1 Chronic diarrhea 1 P50851 17 3.75e-02 34 3 1 0.333 0.029 HP:0040088 hp 1 Abnormal lymphocyte count 1 P50851 17 3.75e-02 34 3 1 0.333 0.029 HP:0002097 hp 1 Emphysema 1 P50851 17 3.80e-02 1493 3 2 0.667 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 Q8NFP9,Q7Z3Z2 17 3.87e-02 4305 3 3 1.000 0.001 TF:M04081_0 tf 1 Factor: POU3F3; motif: WTGMATAAWTWA; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 3.88e-02 4310 3 3 1.000 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 Q8NFP9,Q7Z3Z2,P50851 17 3.97e-02 36 3 1 0.333 0.028 HP:0011840 hp 1 Abnormality of T cell physiology 1 P50851 17 4.07e-02 175 3 1 0.333 0.006 TF:M07228_0 tf 1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 0 1 Q8NFP9 17 4.08e-02 37 3 1 0.333 0.027 HP:0002037 hp 1 Inflammation of the large intestine 1 P50851 17 4.08e-02 37 3 1 0.333 0.027 HP:0008002 hp 1 Abnormality of macular pigmentation 1 Q7Z3Z2 17 4.11e-02 177 3 1 0.333 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q8NFP9 17 4.12e-02 1557 3 2 0.667 0.001 TF:M07044_1 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 1 Q8NFP9,P50851 17 4.22e-02 1337 3 2 0.667 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q8NFP9,P50851 17 4.27e-02 184 3 1 0.333 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 Q7Z3Z2 17 4.29e-02 39 3 1 0.333 0.026 HP:0005425 hp 1 Recurrent sinopulmonary infections 1 P50851 17 4.44e-02 191 3 1 0.333 0.005 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 P50851 17 4.44e-02 191 3 1 0.333 0.005 TF:M04323_1 tf 1 Factor: GBX2; motif: TAATTGNNCAATTA; match class: 1 1 Q8NFP9 17 4.44e-02 4506 3 3 1.000 0.001 TF:M07267_0 tf 1 Factor: SF-1; motif: TGRCCTTGR; match class: 0 1 Q8NFP9,Q7Z3Z2,P50851 17 4.57e-02 197 3 1 0.333 0.005 TF:M01212_0 tf 1 Factor: STAT1:STAT1; motif: NTTTCCMGGAAAA; match class: 0 1 Q8NFP9 17 4.62e-02 42 3 1 0.333 0.024 HP:0004295 hp 1 Abnormality of the gastric mucosa 1 P50851 17 4.69e-02 352 3 2 0.667 0.006 HP:0002240 hp 1 Hepatomegaly 1 Q7Z3Z2,P50851 17 4.71e-02 203 3 1 0.333 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 P50851 17 4.72e-02 1672 3 2 0.667 0.001 TF:M01725_0 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 0 1 Q7Z3Z2,P50851 17 4.73e-02 43 3 1 0.333 0.023 HP:0011108 hp 1 Recurrent sinusitis 1 P50851 17 4.73e-02 1419 3 2 0.667 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q8NFP9,P50851 17 4.81e-02 1688 3 2 0.667 0.001 TF:M07426_0 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 0 1 Q8NFP9,P50851 17 4.83e-02 44 3 1 0.333 0.023 HP:0002633 hp 1 Vasculitis 1 P50851 17 4.91e-02 1707 3 2 0.667 0.001 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q8NFP9,P50851 17 4.94e-02 45 3 1 0.333 0.022 HP:0001888 hp 1 Lymphopenia 1 P50851 17 4.98e-02 1459 3 2 0.667 0.001 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q8NFP9,P50851 17 5.00e-02 14 3 1 0.333 0.071 OMIM:204000 omi 1 Leber Congenital Amaurosis 1 Q7Z3Z2 17 5.00e-02 147 3 1 0.333 0.007 GO:0005802 CC 1 trans-Golgi network 1 Q8NFP9 18 9.34e-06 117 3 3 1.000 0.026 GO:0008154 BP 1 actin polymerization or depolymerization 1 O43639,O00401,Q9UPY6 18 2.87e-05 22 3 2 0.667 0.091 REAC:373753 rea 1 Nephrin interactions 1 O43639,O00401 18 5.62e-05 212 3 3 1.000 0.014 GO:0007015 BP 1 actin filament organization 1 O43639,O00401,Q9UPY6 18 7.82e-05 36 3 2 0.667 0.056 REAC:5663213 rea 1 RHO GTPases Activate WASPs and WAVEs 1 O00401,Q9UPY6 18 2.12e-04 59 3 2 0.667 0.034 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 O00401,Q9UPY6 18 2.72e-04 358 3 3 1.000 0.008 GO:0030036 BP 1 actin cytoskeleton organization 1 O43639,O00401,Q9UPY6 18 3.05e-04 50 3 2 0.667 0.040 KEGG:05130 keg 1 Pathogenic Escherichia coli infection 1 O43639,O00401 18 4.01e-04 81 3 2 0.667 0.025 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 O00401,Q9UPY6 18 4.21e-04 83 3 2 0.667 0.024 REAC:2682334 rea 1 EPH-Ephrin signaling 1 O43639,O00401 18 4.37e-04 419 3 3 1.000 0.007 GO:0030029 BP 1 actin filament-based process 1 O43639,O00401,Q9UPY6 18 5.40e-04 94 3 2 0.667 0.021 REAC:1500931 rea 1 Cell-Cell communication 1 O43639,O00401 18 6.01e-04 70 3 2 0.667 0.029 KEGG:04520 keg 1 Adherens junction 1 O00401,Q9UPY6 18 8.86e-04 85 3 2 0.667 0.024 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 O00401,Q9UPY6 18 9.07e-04 86 3 2 0.667 0.023 KEGG:05231 keg 1 Choline metabolism in cancer 1 O00401,Q9UPY6 18 1.05e-03 72 3 2 0.667 0.028 GO:0048013 BP 1 ephrin receptor signaling pathway 1 O43639,O00401 18 1.80e-03 94 3 2 0.667 0.021 GO:0030041 BP 1 actin filament polymerization 1 O43639,Q9UPY6 18 2.25e-03 5 3 1 0.333 0.200 REAC:203641 rea 1 NOSTRIN mediated eNOS trafficking 1 O00401 18 2.60e-03 758 3 3 1.000 0.004 GO:0007010 BP 1 cytoskeleton organization 1 O43639,O00401,Q9UPY6 18 3.24e-03 231 3 2 0.667 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 O00401,Q9UPY6 18 3.56e-03 842 3 3 1.000 0.004 GO:0006461 BP 1 protein complex assembly 1 O43639,O00401,Q9UPY6 18 3.56e-03 842 3 3 1.000 0.004 GO:0070271 BP 1 protein complex biogenesis 1 O43639,O00401,Q9UPY6 18 4.48e-03 272 3 2 0.667 0.007 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 O43639,Q9UPY6 18 4.59e-03 150 3 2 0.667 0.013 GO:0051258 BP 1 protein polymerization 1 O43639,Q9UPY6 18 4.67e-03 278 3 2 0.667 0.007 REAC:194138 rea 1 Signaling by VEGF 1 O43639,Q9UPY6 18 4.78e-03 2 3 1 0.333 0.500 GO:2000402 BP 1 negative regulation of lymphocyte migration 1 O00401 18 4.78e-03 2 3 1 0.333 0.500 GO:1903526 BP 1 negative regulation of membrane tubulation 1 O00401 18 6.24e-03 1015 3 3 1.000 0.003 GO:0071822 BP 1 protein complex subunit organization 1 O43639,O00401,Q9UPY6 18 6.29e-03 14 3 1 0.333 0.071 REAC:418885 rea 1 DCC mediated attractive signaling 1 O00401 18 6.29e-03 14 3 1 0.333 0.071 REAC:428540 rea 1 Activation of Rac 1 O43639 18 6.87e-03 338 3 2 0.667 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 O00401,Q9UPY6 18 7.17e-03 3 3 1 0.333 0.333 GO:1903912 BP 1 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 1 O43639 18 7.63e-03 17 3 1 0.333 0.059 REAC:3928664 rea 1 Ephrin signaling 1 O43639 18 8.23e-03 1113 3 3 1.000 0.003 GO:0065003 BP 1 macromolecular complex assembly 1 O43639,O00401,Q9UPY6 18 8.53e-03 19 3 1 0.333 0.053 REAC:202131 rea 1 Metabolism of nitric oxide 1 O00401 18 8.53e-03 19 3 1 0.333 0.053 REAC:203765 rea 1 eNOS activation and regulation 1 O00401 18 9.52e-03 1168 3 3 1.000 0.003 GO:1902589 BP 1 single-organism organelle organization 1 O43639,O00401,Q9UPY6 18 9.55e-03 4 3 1 0.333 0.250 GO:0030050 BP 1 vesicle transport along actin filament 1 O00401 18 9.55e-03 4 3 1 0.333 0.250 GO:1903525 BP 1 regulation of membrane tubulation 1 O00401 18 1.12e-02 1575 3 3 1.000 0.002 REAC:162582 rea 1 Signal Transduction 1 O43639,O00401,Q9UPY6 18 1.19e-02 5 3 1 0.333 0.200 GO:0036491 BP 1 regulation of translation initiation in response to endoplasmic reticulum stress 1 O43639 18 1.19e-02 5 3 1 0.333 0.200 GO:0036492 BP 1 eiF2alpha phosphorylation in response to endoplasmic reticulum stress 1 O43639 18 1.19e-02 5 3 1 0.333 0.200 GO:2000370 BP 1 positive regulation of clathrin-dependent endocytosis 1 O00401 18 1.25e-02 459 3 2 0.667 0.004 REAC:422475 rea 1 Axon guidance 1 O43639,O00401 18 1.39e-02 31 3 1 0.333 0.032 REAC:376176 rea 1 Signaling by Robo receptor 1 O43639 18 1.42e-02 264 3 2 0.667 0.008 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 O43639,O00401 18 1.43e-02 6 3 1 0.333 0.167 GO:0099515 BP 1 actin filament-based transport 1 O00401 18 1.43e-02 6 3 1 0.333 0.167 GO:0036490 BP 1 regulation of translation in response to endoplasmic reticulum stress 1 O43639 18 1.67e-02 7 3 1 0.333 0.143 GO:0010998 BP 1 regulation of translational initiation by eIF2 alpha phosphorylation 1 O43639 18 1.67e-02 7 3 1 0.333 0.143 GO:0007172 BP 1 signal complex assembly 1 O43639 18 1.70e-02 38 3 1 0.333 0.026 REAC:373752 rea 1 Netrin-1 signaling 1 O00401 18 1.75e-02 39 3 1 0.333 0.026 REAC:3928662 rea 1 EPHB-mediated forward signaling 1 O00401 18 1.78e-02 1438 3 3 1.000 0.002 GO:0051128 BP 1 regulation of cellular component organization 1 O43639,O00401,Q9UPY6 18 1.85e-02 872 3 2 0.667 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 O43639,Q9UPY6 18 1.91e-02 8 3 1 0.333 0.125 GO:0002686 BP 1 negative regulation of leukocyte migration 1 O00401 18 2.50e-02 1 3 1 0.333 1.000 CORUM:2513 cor 1 N-WASp homomer 1 O00401 18 2.51e-02 1614 3 3 1.000 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 O43639,O00401,Q9UPY6 18 2.86e-02 12 3 1 0.333 0.083 GO:0043558 BP 1 regulation of translational initiation in response to stress 1 O43639 18 2.97e-02 1706 3 3 1.000 0.002 GO:0022607 BP 1 cellular component assembly 1 O43639,O00401,Q9UPY6 18 2.99e-02 718 3 2 0.667 0.003 REAC:1266738 rea 1 Developmental Biology 1 O43639,O00401 18 3.09e-02 391 3 2 0.667 0.005 GO:0043623 BP 1 cellular protein complex assembly 1 O43639,Q9UPY6 18 3.10e-02 13 3 1 0.333 0.077 GO:2000369 BP 1 regulation of clathrin-dependent endocytosis 1 O00401 18 3.34e-02 14 3 1 0.333 0.071 GO:0007176 BP 1 regulation of epidermal growth factor-activated receptor activity 1 O43639 18 3.34e-02 14 3 1 0.333 0.071 GO:0008093 MF 1 cytoskeletal adaptor activity 1 O43639 18 3.48e-02 3524 3 3 1.000 0.001 HPA:038010_02 hpa 1 smooth muscle; smooth muscle cells[Uncertain,Medium] 1 O43639,O00401,Q9UPY6 18 3.58e-02 15 3 1 0.333 0.067 GO:0051491 BP 1 positive regulation of filopodium assembly 1 O00401 18 3.58e-02 15 3 1 0.333 0.067 GO:2000401 BP 1 regulation of lymphocyte migration 1 O00401 18 3.58e-02 15 3 1 0.333 0.067 GO:0005086 MF 1 ARF guanyl-nucleotide exchange factor activity 1 O43639 18 3.58e-02 15 3 1 0.333 0.067 GO:0097320 BP 1 membrane tubulation 1 O00401 18 3.76e-02 432 3 2 0.667 0.005 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 O43639,O00401 18 3.82e-02 16 3 1 0.333 0.062 GO:0033137 BP 1 negative regulation of peptidyl-serine phosphorylation 1 O43639 18 3.82e-02 16 3 1 0.333 0.062 GO:0043555 BP 1 regulation of translation in response to stress 1 O43639 18 3.89e-02 62 3 1 0.333 0.016 KEGG:05131 keg 1 Shigellosis 1 O00401 18 3.94e-02 3675 3 3 1.000 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 O43639,O00401,Q9UPY6 18 4.20e-02 67 3 1 0.333 0.015 KEGG:05132 keg 1 Salmonella infection 1 O00401 18 4.29e-02 18 3 1 0.333 0.056 GO:0030159 MF 1 receptor signaling complex scaffold activity 1 O43639 18 4.31e-02 1932 3 3 1.000 0.002 GO:0044085 BP 1 cellular component biogenesis 1 O43639,O00401,Q9UPY6 18 4.48e-02 1380 3 2 0.667 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 O43639,Q9UPY6 18 4.57e-02 73 3 1 0.333 0.014 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 O00401 18 5.00e-02 80 3 1 0.333 0.013 KEGG:04012 keg 1 ErbB signaling pathway 1 O43639 18 5.00e-02 499 3 2 0.667 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 O43639,O00401 18 5.00e-02 575 3 3 1.000 0.005 TF:M03913_0 tf 1 Factor: KLF14; motif: NRCCACGCCCMCYN; match class: 0 1 O43639,O00401,Q9UPY6 18 5.00e-02 2 3 1 0.333 0.500 CORUM:2297 cor 1 ABI1-WASL complex 1 O00401 18 5.00e-02 938 3 2 0.667 0.002 REAC:168249 rea 1 Innate Immune System 1 O00401,Q9UPY6 19 1.58e-03 507 2 2 1.000 0.004 TF:M01249_0 tf 1 Factor: HIF2alpha; motif: NNACGTGCNN; match class: 0 1 P53667,Q5JXC2 19 3.45e-03 22 2 1 0.500 0.045 TF:M04222_0 tf 1 Factor: NFE2; motif: NATGACTCATS; match class: 0 1 P53667 19 3.77e-03 24 2 1 0.500 0.042 TF:M04174_1 tf 1 Factor: ID4; motif: NRCACCTGNN; match class: 1 1 P53667 19 6.17e-03 1000 2 2 1.000 0.002 TF:M01241_0 tf 1 Factor: BEN; motif: CWGCGAYA; match class: 0 1 P53667,Q5JXC2 19 8.62e-03 55 2 1 0.500 0.018 TF:M06393_0 tf 1 Factor: ZNF765; motif: NTGGYAAGGRSA; match class: 0 1 P53667 19 9.78e-03 7 2 1 0.500 0.143 HP:0010794 hp 1 Impaired visuospatial constructive cognition 1 P53667 19 9.78e-03 7 2 1 0.500 0.143 HP:0004764 hp 1 Myxomatous mitral valve degeneration 1 P53667 19 9.78e-03 7 2 1 0.500 0.143 HP:0005145 hp 1 Coronary artery stenosis 1 P53667 19 9.89e-03 15 2 1 0.500 0.067 GO:0045773 BP 1 positive regulation of axon extension 1 P53667 19 9.92e-03 16 2 1 0.500 0.062 REAC:399954 rea 1 Sema3A PAK dependent Axon repulsion 1 P53667 19 1.05e-02 67 2 1 0.500 0.015 TF:M07372_1 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 1 1 Q5JXC2 19 1.05e-02 17 2 1 0.500 0.059 REAC:5627117 rea 1 RHO GTPases Activate ROCKs 1 P53667 19 1.12e-02 8 2 1 0.500 0.125 HP:0012450 hp 1 Chronic constipation 1 P53667 19 1.12e-02 8 2 1 0.500 0.125 HP:0001136 hp 1 Retinal arteriolar tortuosity 1 P53667 19 1.12e-02 8 2 1 0.500 0.125 HP:0004381 hp 1 Supravalvular aortic stenosis 1 P53667 19 1.24e-02 20 2 1 0.500 0.050 REAC:5627123 rea 1 RHO GTPases activate PAKs 1 P53667 19 1.26e-02 9 2 1 0.500 0.111 HP:0002608 hp 1 Celiac disease 1 P53667 19 1.26e-02 9 2 1 0.500 0.111 HP:0004428 hp 1 Elfin facies 1 P53667 19 1.26e-02 9 2 1 0.500 0.111 HP:0008770 hp 1 Obsessive-compulsive trait 1 P53667 19 1.36e-02 87 2 1 0.500 0.011 TF:M01724_0 tf 1 Factor: T3RALPHA; motif: NNTSRGGTCAN; match class: 0 1 Q5JXC2 19 1.39e-02 1499 2 2 1.000 0.001 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 P53667,Q5JXC2 19 1.40e-02 10 2 1 0.500 0.100 HP:0007720 hp 1 Flat cornea 1 P53667 19 1.40e-02 10 2 1 0.500 0.100 HP:0001605 hp 1 Vocal cord paralysis 1 P53667 19 1.40e-02 10 2 1 0.500 0.100 HP:0100785 hp 1 Insomnia 1 P53667 19 1.43e-02 23 2 1 0.500 0.043 REAC:416572 rea 1 Sema4D induced cell migration and growth-cone collapse 1 P53667 19 1.44e-02 1529 2 2 1.000 0.001 TF:M07384_0 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 0 1 P53667,Q5JXC2 19 1.51e-02 1565 2 2 1.000 0.001 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 P53667,Q5JXC2 19 1.53e-02 11 2 1 0.500 0.091 HP:0100817 hp 1 Renovascular hypertension 1 P53667 19 1.53e-02 11 2 1 0.500 0.091 HP:0010780 hp 1 Hyperacusis 1 P53667 19 1.55e-02 1584 2 2 1.000 0.001 TF:M00284_0 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 0 1 P53667,Q5JXC2 19 1.58e-02 1598 2 2 1.000 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 P53667,Q5JXC2 19 1.61e-02 26 2 1 0.500 0.038 REAC:400685 rea 1 Sema4D in semaphorin signaling 1 P53667 19 1.65e-02 25 2 1 0.500 0.040 GO:0050772 BP 1 positive regulation of axonogenesis 1 P53667 19 1.66e-02 106 2 1 0.500 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 P53667 19 1.67e-02 12 2 1 0.500 0.083 HP:0002623 hp 1 Overriding aorta 1 P53667 19 1.67e-02 12 2 1 0.500 0.083 HP:0007099 hp 1 Arnold-Chiari type I malformation 1 P53667 19 1.77e-02 113 2 1 0.500 0.009 TF:M00284_1 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 1 1 Q5JXC2 19 1.78e-02 27 2 1 0.500 0.037 GO:0032233 BP 1 positive regulation of actin filament bundle assembly 1 P53667 19 1.81e-02 13 2 1 0.500 0.077 HP:0000075 hp 1 Renal duplication 1 P53667 19 1.81e-02 13 2 1 0.500 0.077 HP:0002183 hp 1 Phonophobia 1 P53667 19 1.95e-02 14 2 1 0.500 0.071 HP:0004969 hp 1 Peripheral pulmonary artery stenosis 1 P53667 19 1.97e-02 126 2 1 0.500 0.008 TF:M03835_1 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 1 1 P53667 19 2.11e-02 135 2 1 0.500 0.007 TF:M03904_0 tf 1 Factor: GLIS2; motif: GACCCCCCGCRANG; match class: 0 1 P53667 19 2.13e-02 136 2 1 0.500 0.007 TF:M06262_0 tf 1 Factor: ZNF415; motif: NGGGGAAWCAGA; match class: 0 1 P53667 19 2.21e-02 1894 2 2 1.000 0.001 TF:M04385_0 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 0 1 P53667,Q5JXC2 19 2.23e-02 16 2 1 0.500 0.062 HP:0000629 hp 1 Periorbital fullness 1 P53667 19 2.23e-02 16 2 1 0.500 0.062 HP:0000015 hp 1 Bladder diverticulum 1 P53667 19 2.27e-02 1916 2 2 1.000 0.001 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 P53667,Q5JXC2 19 2.37e-02 17 2 1 0.500 0.059 HP:0001920 hp 1 Renal artery stenosis 1 P53667 19 2.37e-02 17 2 1 0.500 0.059 HP:0008776 hp 1 Abnormality of the renal artery 1 P53667 19 2.37e-02 152 2 1 0.500 0.007 TF:M02263_0 tf 1 Factor: NFE2L2; motif: RTGACWCAGCA; match class: 0 1 P53667 19 2.41e-02 39 2 1 0.500 0.026 REAC:3928662 rea 1 EPHB-mediated forward signaling 1 P53667 19 2.51e-02 18 2 1 0.500 0.056 HP:0002253 hp 1 Colonic diverticula 1 P53667 19 2.64e-02 2070 2 2 1.000 0.001 TF:M05961_0 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 0 1 P53667,Q5JXC2 19 2.65e-02 19 2 1 0.500 0.053 HP:0200021 hp 1 Down-sloping shoulders 1 P53667 19 2.79e-02 20 2 1 0.500 0.050 HP:0010880 hp 1 Increased nuchal translucency 1 P53667 19 2.79e-02 20 2 1 0.500 0.050 HP:0002035 hp 1 Rectal prolapse 1 P53667 19 2.79e-02 20 2 1 0.500 0.050 HP:0009748 hp 1 Large earlobe 1 P53667 19 2.86e-02 2153 2 2 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 P53667,Q5JXC2 19 2.86e-02 2153 2 2 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 P53667,Q5JXC2 19 2.90e-02 44 2 1 0.500 0.023 GO:0032231 BP 1 regulation of actin filament bundle assembly 1 P53667 19 2.92e-02 21 2 1 0.500 0.048 HP:0008661 hp 1 Urethral stenosis 1 P53667 19 2.93e-02 188 2 1 0.500 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 Q5JXC2 19 2.96e-02 45 2 1 0.500 0.022 GO:0030516 BP 1 regulation of axon extension 1 P53667 19 3.10e-02 47 2 1 0.500 0.021 GO:0061387 BP 1 regulation of extent of cell growth 1 P53667 19 3.12e-02 200 2 1 0.500 0.005 TF:M00997_1 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 1 1 P53667 19 3.12e-02 361 2 2 1.000 0.006 MI:mmu-miR-712 mi 1 MI:mmu-miR-712 1 P53667,Q5JXC2 19 3.20e-02 23 2 1 0.500 0.043 HP:0004415 hp 1 Pulmonary artery stenosis 1 P53667 19 3.20e-02 23 2 1 0.500 0.043 HP:0005222 hp 1 Bowel diverticulosis 1 P53667 19 3.23e-02 49 2 1 0.500 0.020 GO:0048639 BP 1 positive regulation of developmental growth 1 P53667 19 3.33e-02 85 2 1 0.500 0.012 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 P53667 19 3.34e-02 24 2 1 0.500 0.042 HP:0000796 hp 1 Urethral obstruction 1 P53667 19 3.34e-02 24 2 1 0.500 0.042 HP:0012841 hp 1 Retinal vascular tortuosity 1 P53667 19 3.36e-02 51 2 1 0.500 0.020 GO:0031072 MF 1 heat shock protein binding 1 P53667 19 3.48e-02 25 2 1 0.500 0.040 HP:0005344 hp 1 Abnormality of the carotid arteries 1 P53667 19 3.49e-02 2378 2 2 1.000 0.001 TF:M07305_0 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 0 1 P53667,Q5JXC2 19 3.65e-02 59 2 1 0.500 0.017 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 P53667 19 3.65e-02 59 2 1 0.500 0.017 REAC:373755 rea 1 Semaphorin interactions 1 P53667 19 3.68e-02 2443 2 2 1.000 0.001 TF:M07066_0 tf 1 Factor: STAT6; motif: TTCYYNGGAAN; match class: 0 1 P53667,Q5JXC2 19 3.76e-02 27 2 1 0.500 0.037 HP:0010747 hp 1 Medial flaring of the eyebrow 1 P53667 19 3.76e-02 27 2 1 0.500 0.037 HP:0002141 hp 1 Gait imbalance 1 P53667 19 3.76e-02 27 2 1 0.500 0.037 HP:0010662 hp 1 Abnormality of the diencephalon 1 P53667 19 3.79e-02 2478 2 2 1.000 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 P53667,Q5JXC2 19 3.89e-02 28 2 1 0.500 0.036 HP:0001409 hp 1 Portal hypertension 1 P53667 19 3.89e-02 28 2 1 0.500 0.036 HP:0002999 hp 1 Patellar dislocation 1 P53667 19 3.89e-02 28 2 1 0.500 0.036 HP:0000635 hp 1 Blue irides 1 P53667 19 3.95e-02 60 2 1 0.500 0.017 GO:0010770 BP 1 positive regulation of cell morphogenesis involved in differentiation 1 P53667 19 4.02e-02 61 2 1 0.500 0.016 GO:0048675 BP 1 axon extension 1 P53667 19 4.03e-02 29 2 1 0.500 0.034 HP:0000627 hp 1 Posterior embryotoxon 1 P53667 19 4.03e-02 29 2 1 0.500 0.034 HP:0000833 hp 1 Glucose intolerance 1 P53667 19 4.09e-02 263 2 1 0.500 0.004 TF:M06419_0 tf 1 Factor: ZNF493; motif: NGKTAYKGGMGA; match class: 0 1 Q5JXC2 19 4.17e-02 30 2 1 0.500 0.033 HP:0006707 hp 1 Abnormality of the hepatic vasculature 1 P53667 19 4.17e-02 30 2 1 0.500 0.033 HP:0000125 hp 1 Pelvic kidney 1 P53667 19 4.17e-02 30 2 1 0.500 0.033 HP:0008048 hp 1 Abnormality of the line of Schwalbe 1 P53667 19 4.19e-02 2606 2 2 1.000 0.001 TF:M04149_0 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 0 1 P53667,Q5JXC2 19 4.21e-02 64 2 1 0.500 0.016 GO:0007266 BP 1 Rho protein signal transduction 1 P53667 19 4.29e-02 276 2 1 0.500 0.004 TF:M00235_0 tf 1 Factor: AhR:Arnt; motif: KNNKNNTYGCGTGCMS; match class: 0 1 Q5JXC2 19 4.32e-02 2647 2 2 1.000 0.001 TF:M04343_0 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 0 1 P53667,Q5JXC2 19 4.35e-02 280 2 1 0.500 0.004 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 Q5JXC2 19 4.36e-02 2659 2 2 1.000 0.001 TF:M04440_0 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 0 1 P53667,Q5JXC2 19 4.37e-02 281 2 1 0.500 0.004 TF:M03919_1 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 1 1 P53667 19 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 Q5JXC2 19 4.45e-02 32 2 1 0.500 0.031 HP:0003072 hp 1 Hypercalcemia 1 P53667 19 4.48e-02 68 2 1 0.500 0.015 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 P53667 19 4.48e-02 68 2 1 0.500 0.015 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 P53667 19 4.48e-02 68 2 1 0.500 0.015 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 P53667 19 4.49e-02 289 2 1 0.500 0.003 TF:M06379_0 tf 1 Factor: ZNF770; motif: NWGGGGCGAG; match class: 0 1 P53667 19 4.57e-02 294 2 1 0.500 0.003 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 P53667 19 4.59e-02 33 2 1 0.500 0.030 HP:0002150 hp 1 Hypercalciuria 1 P53667 19 4.61e-02 70 2 1 0.500 0.014 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 P53667 19 4.67e-02 71 2 1 0.500 0.014 GO:0008361 BP 1 regulation of cell size 1 P53667 19 4.72e-02 34 2 1 0.500 0.029 HP:0001952 hp 1 Abnormal glucose tolerance 1 P53667 19 4.77e-02 2781 2 2 1.000 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 P53667,Q5JXC2 19 4.87e-02 74 2 1 0.500 0.014 GO:0051444 BP 1 negative regulation of ubiquitin-protein transferase activity 1 P53667 19 4.98e-02 321 2 1 0.500 0.003 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 Q5JXC2 19 5.00e-02 36 2 1 0.500 0.028 HP:0011280 hp 1 Abnormality of urine calcium concentration 1 P53667 19 5.00e-02 81 2 1 0.500 0.012 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 P53667 19 5.00e-02 36 2 1 0.500 0.028 HP:0002370 hp 1 Poor coordination 1 P53667 19 5.00e-02 457 2 2 1.000 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 P53667,Q5JXC2 19 5.00e-02 36 2 1 0.500 0.028 HP:0100539 hp 1 Periorbital edema 1 P53667 19 5.00e-02 76 2 1 0.500 0.013 GO:0050770 BP 1 regulation of axonogenesis 1 P53667 20 2.59e-03 11 3 1 0.333 0.091 TF:M06110_0 tf 1 Factor: Kox1; motif: NTKKATTGCCGC; match class: 0 1 Q9NRU3 20 3.77e-03 16 3 1 0.333 0.062 TF:M00185_1 tf 1 Factor: NF-Y; motif: TRRCCAATSRN; match class: 1 1 P01920 20 4.71e-03 20 3 1 0.333 0.050 TF:M06147_0 tf 1 Factor: ZNF41; motif: NRATAAATGGGA; match class: 0 1 P01920 20 6.11e-03 2328 3 3 1.000 0.001 TF:M03834_0 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 7.52e-03 32 3 1 0.333 0.031 TF:M06679_0 tf 1 Factor: ZNF251; motif: KATAAGACGA; match class: 0 1 Q9NRU3 20 9.87e-03 42 3 1 0.333 0.024 TF:M05410_0 tf 1 Factor: ZSCAN1; motif: GGGKACAYKAGGC; match class: 0 1 P01920 20 1.23e-02 11 3 1 0.333 0.091 KEGG:05310 keg 1 Asthma 1 P01920 20 1.23e-02 13 3 1 0.333 0.077 REAC:202430 rea 1 Translocation of ZAP-70 to Immunological synapse 1 P01920 20 1.32e-02 3008 3 3 1.000 0.001 TF:M00232_0 tf 1 Factor: MEF-2A; motif: NNNNNWKCTAWAAATAGMNNNN; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 1.42e-02 15 3 1 0.333 0.067 REAC:202427 rea 1 Phosphorylation of CD3 and TCR zeta chains 1 P01920 20 1.45e-02 62 3 1 0.333 0.016 TF:M04055_1 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 1 1 P01920 20 1.45e-02 62 3 1 0.333 0.016 TF:M04055_0 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 0 1 P01920 20 1.52e-02 16 3 1 0.333 0.062 REAC:389948 rea 1 PD-1 signaling 1 P01920 20 1.57e-02 67 3 1 0.333 0.015 TF:M00287_1 tf 1 Factor: NF-Y; motif: NNNRRCCAATSRGNNN; match class: 1 1 P01920 20 1.57e-02 946 3 2 0.667 0.002 TF:M00729_1 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 1 1 Q9NRU3,P01920 20 1.80e-02 77 3 1 0.333 0.013 TF:M06650_0 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 0 1 Q9NRU3 20 1.85e-02 3364 3 3 1.000 0.001 TF:M01875_0 tf 1 Factor: ER-beta; motif: GTCANASTGRCCYNR; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 2.01e-02 18 3 1 0.333 0.056 KEGG:05330 keg 1 Allograft rejection 1 P01920 20 2.04e-02 87 3 1 0.333 0.011 TF:M01724_0 tf 1 Factor: T3RALPHA; motif: NNTSRGGTCAN; match class: 0 1 P01920 20 2.23e-02 20 3 1 0.333 0.050 KEGG:05332 keg 1 Graft-versus-host disease 1 P01920 20 2.34e-02 21 3 1 0.333 0.048 KEGG:04672 keg 1 Intestinal immune network for IgA production 1 P01920 20 2.46e-02 26 3 1 0.333 0.038 REAC:202433 rea 1 Generation of second messenger molecules 1 P01920 20 2.57e-02 23 3 1 0.333 0.043 KEGG:04940 keg 1 Type I diabetes mellitus 1 P01920 20 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q9NRU3 20 2.94e-02 126 3 1 0.333 0.008 TF:M00045_0 tf 1 Factor: E4BP4; motif: NRTTAYGTAAYN; match class: 0 1 P01920 20 3.01e-02 27 3 1 0.333 0.037 KEGG:05320 keg 1 Autoimmune thyroid disease 1 P01920 20 3.17e-02 4029 3 3 1.000 0.001 TF:M01199_1 tf 1 Factor: RNF96; motif: BCCCGCRGCC; match class: 1 1 Q9NRU3,Q8NE01,P01920 20 3.17e-02 136 3 1 0.333 0.007 TF:M00157_1 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 1 1 P01920 20 3.22e-02 138 3 1 0.333 0.007 TF:M02091_0 tf 1 Factor: E4F1; motif: RTGACGTAAC; match class: 0 1 Q8NE01 20 3.34e-02 30 3 1 0.333 0.033 KEGG:05150 keg 1 Staphylococcus aureus infection 1 P01920 20 3.36e-02 4107 3 3 1.000 0.001 TF:M00729_0 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 3.40e-02 146 3 1 0.333 0.007 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 Q8NE01 20 3.54e-02 1220 3 2 0.667 0.002 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 Q8NE01,P01920 20 3.61e-02 4206 3 3 1.000 0.001 TF:M01243_1 tf 1 Factor: MTF-1; motif: TGCGCAC; match class: 1 1 Q9NRU3,Q8NE01,P01920 20 3.61e-02 1453 3 2 0.667 0.001 TF:M00147_1 tf 1 Factor: HSF2; motif: NGAANNWTCK; match class: 1 1 Q9NRU3,Q8NE01 20 3.63e-02 4214 3 3 1.000 0.001 TF:M07261_0 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 3.63e-02 4215 3 3 1.000 0.001 TF:M02271_0 tf 1 Factor: HOXA5; motif: CDBWAATK; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 3.75e-02 4260 3 3 1.000 0.001 TF:M00474_0 tf 1 Factor: FOXO1; motif: GNNTTGTTTACNTT; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 3.79e-02 34 3 1 0.333 0.029 KEGG:05321 keg 1 Inflammatory bowel disease (IBD) 1 P01920 20 3.93e-02 1519 3 2 0.667 0.001 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 Q9NRU3,P01920 20 4.11e-02 177 3 1 0.333 0.006 TF:M00694_0 tf 1 Factor: E4F1; motif: SYTACGTCAC; match class: 0 1 Q8NE01 20 4.12e-02 37 3 1 0.333 0.027 KEGG:04640 keg 1 Hematopoietic cell lineage 1 P01920 20 4.41e-02 161 3 1 0.333 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q8NE01 20 4.41e-02 1614 3 2 0.667 0.001 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 Q9NRU3,P01920 20 4.46e-02 192 3 1 0.333 0.005 TF:M01119_0 tf 1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 0 1 P01920 20 4.58e-02 1645 3 2 0.667 0.001 TF:M07420_0 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 0 1 Q8NE01,P01920 20 4.73e-02 4603 3 3 1.000 0.001 TF:M03924_0 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 0 1 Q9NRU3,Q8NE01,P01920 20 4.73e-02 1674 3 2 0.667 0.001 TF:M00157_0 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 0 1 Q8NE01,P01920 20 4.89e-02 44 3 1 0.333 0.023 KEGG:05416 keg 1 Viral myocarditis 1 P01920 20 4.94e-02 1712 3 2 0.667 0.001 TF:M04619_0 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 0 1 Q9NRU3,P01920 20 5.00e-02 4 3 1 0.333 0.250 HP:0002494 hp 1 Abnormal rapid eye movement sleep 1 P01920 20 5.00e-02 4 3 1 0.333 0.250 HP:0001370 hp 1 Rheumatoid arthritis 1 P01920 20 5.00e-02 4 3 1 0.333 0.250 HP:0002519 hp 1 Hypnagogic hallucinations 1 P01920 20 5.00e-02 4 3 1 0.333 0.250 HP:0006896 hp 1 Hypnopompic hallucinations 1 P01920 20 5.00e-02 53 3 1 0.333 0.019 REAC:388841 rea 1 Costimulation by the CD28 family 1 P01920 20 5.00e-02 45 3 1 0.333 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P01920 20 5.00e-02 4 3 1 0.333 0.250 HP:0002330 hp 1 Paroxysmal drowsiness 1 P01920 21 3.14e-03 20 2 1 0.500 0.050 TF:M06331_0 tf 1 Factor: ZNF343; motif: KGGTCCGGCCGA; match class: 0 1 Q9NX36 21 5.28e-03 16 2 1 0.500 0.062 REAC:163210 rea 1 Formation of ATP by chemiosmotic coupling 1 P24539 21 5.81e-03 37 2 1 0.500 0.027 TF:M05993_0 tf 1 Factor: ZNF711; motif: NTGCGTGCGC; match class: 0 1 Q9NX36 21 7.06e-03 45 2 1 0.500 0.022 TF:M06272_0 tf 1 Factor: ZNF569; motif: KGKGGGTGRATM; match class: 0 1 P24539 21 8.00e-03 51 2 1 0.500 0.020 TF:M06296_0 tf 1 Factor: ZNF568; motif: NTGGGKAAAAGA; match class: 0 1 P24539 21 8.00e-03 51 2 1 0.500 0.020 TF:M06981_0 tf 1 Factor: PRDM12; motif: NGACAGNTKACC; match class: 0 1 Q9NX36 21 1.03e-02 66 2 1 0.500 0.015 TF:M05546_1 tf 1 Factor: EOS; motif: TGGTTATM; match class: 1 1 Q9NX36 21 1.07e-02 68 2 1 0.500 0.015 TF:M05617_0 tf 1 Factor: ZNF500; motif: NGTTCCGGGGRW; match class: 0 1 Q9NX36 21 1.08e-02 69 2 1 0.500 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 P24539 21 1.34e-02 1474 2 2 1.000 0.001 TF:M01211_0 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 0 1 P24539,Q9NX36 21 1.40e-02 1507 2 2 1.000 0.001 TF:M07325_1 tf 1 Factor: MaFA; motif: TCTGCTGASCNN; match class: 1 1 P24539,Q9NX36 21 1.42e-02 91 2 1 0.500 0.011 TF:M01716_1 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 1 1 Q9NX36 21 1.56e-02 1588 2 2 1.000 0.001 TF:M03796_1 tf 1 Factor: MafA; motif: GGTCAGCAGH; match class: 1 1 P24539,Q9NX36 21 1.64e-02 1632 2 2 1.000 0.001 TF:M03877_0 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 0 1 P24539,Q9NX36 21 1.67e-02 2 2 1 0.500 0.500 GO:0048213 BP 1 Golgi vesicle prefusion complex stabilization 1 Q9NX36 21 1.78e-02 114 2 1 0.500 0.009 TF:M04218_1 tf 1 Factor: MAFK; motif: NTGCTGANTCAGCRN; match class: 1 1 Q9NX36 21 1.86e-02 119 2 1 0.500 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 Q9NX36 21 1.94e-02 1775 2 2 1.000 0.001 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 P24539,Q9NX36 21 2.17e-02 139 2 1 0.500 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q9NX36 21 2.19e-02 140 2 1 0.500 0.007 TF:M00437_0 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 0 1 P24539 21 2.30e-02 147 2 1 0.500 0.007 TF:M05926_0 tf 1 Factor: ZNF700; motif: NACKACTAGTSN; match class: 0 1 P24539 21 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q9NX36 21 2.50e-02 3 2 1 0.500 0.333 GO:0045263 CC 1 proton-transporting ATP synthase complex, coupling factor F(o) 1 P24539 21 2.50e-02 3 2 1 0.500 0.333 GO:0000276 CC 1 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 1 P24539 21 2.54e-02 1722 2 2 1.000 0.001 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P24539,Q9NX36 21 2.73e-02 394 2 2 1.000 0.005 MI:mmu-miR-706 mi 1 MI:mmu-miR-706 1 P24539,Q9NX36 21 2.75e-02 176 2 1 0.500 0.006 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 P24539 21 3.00e-02 2204 2 2 1.000 0.001 TF:M01107_1 tf 1 Factor: RUSH-1alpha; motif: NNMCWTNKNN; match class: 1 1 P24539,Q9NX36 21 3.02e-02 2213 2 2 1.000 0.001 TF:M00724_1 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 1 1 P24539,Q9NX36 21 3.09e-02 2238 2 2 1.000 0.001 TF:M00918_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 P24539,Q9NX36 21 3.15e-02 2261 2 2 1.000 0.001 TF:M03548_0 tf 1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 0 1 P24539,Q9NX36 21 3.30e-02 2314 2 2 1.000 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 P24539,Q9NX36 21 3.33e-02 4 2 1 0.500 0.250 GO:0033177 CC 1 proton-transporting two-sector ATPase complex, proton-transporting domain 1 P24539 21 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 P24539,Q9NX36 21 3.61e-02 110 2 1 0.500 0.009 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P24539 21 3.71e-02 2451 2 2 1.000 0.001 TF:M00076_1 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 1 1 P24539,Q9NX36 21 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 P24539,Q9NX36 21 3.89e-02 250 2 1 0.500 0.004 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 P24539 21 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 P24539,Q9NX36 21 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 P24539 21 4.19e-02 2605 2 2 1.000 0.001 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 P24539,Q9NX36 21 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 P24539 21 4.24e-02 2620 2 2 1.000 0.001 TF:M04430_0 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 0 1 P24539,Q9NX36 21 4.26e-02 2628 2 2 1.000 0.001 TF:M04393_1 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 1 1 P24539,Q9NX36 21 4.32e-02 2646 2 2 1.000 0.001 TF:M00632_0 tf 1 Factor: GATA-4; motif: AGATADMAGGGA; match class: 0 1 P24539,Q9NX36 21 4.40e-02 283 2 1 0.500 0.004 TF:M00424_0 tf 1 Factor: Nkx6-1; motif: TWTTTAATTGGTT; match class: 0 1 P24539 21 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 P24539 21 4.51e-02 290 2 1 0.500 0.003 TF:M04233_1 tf 1 Factor: FOXC1; motif: NGTMAATATTKACN; match class: 1 1 P24539 21 4.54e-02 292 2 1 0.500 0.003 TF:M04259_1 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 1 1 P24539 21 4.54e-02 292 2 1 0.500 0.003 TF:M04255_1 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 1 1 P24539 21 4.54e-02 292 2 1 0.500 0.003 TF:M04247_1 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 1 1 P24539 21 4.54e-02 292 2 1 0.500 0.003 TF:M07138_0 tf 1 Factor: p63; motif: NNRCAWGYNCARRCWTGYNN; match class: 0 1 P24539 21 4.63e-02 513 2 2 1.000 0.004 MI:hsa-miR-106b mi 1 MI:hsa-miR-106b 1 P24539,Q9NX36 21 4.63e-02 513 2 2 1.000 0.004 MI:hsa-miR-495 mi 1 MI:hsa-miR-495 1 P24539,Q9NX36 21 4.80e-02 309 2 1 0.500 0.003 TF:M05390_0 tf 1 Factor: TBPL2; motif: CTTTTAAATC; match class: 0 1 P24539 21 4.90e-02 316 2 1 0.500 0.003 TF:M00651_0 tf 1 Factor: NF-muE1; motif: CGGCCATCT; match class: 0 1 P24539 21 4.94e-02 270 2 1 0.500 0.004 HPA:040040_03 hpa 1 soft tissue 2; peripheral nerve[Uncertain,High] 1 Q9NX36 21 4.97e-02 2837 2 2 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 P24539,Q9NX36 21 4.97e-02 2837 2 2 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 P24539,Q9NX36 21 5.00e-02 153 2 1 0.500 0.007 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P24539 21 5.00e-02 533 2 2 1.000 0.004 MI:hsa-miR-17 mi 1 MI:hsa-miR-17 1 P24539,Q9NX36 21 5.00e-02 15 2 1 0.500 0.067 CORUM:563 cor 1 F1F0-ATP synthase (EC 3.6.3.14), mitochondrial 1 P24539 21 5.00e-02 6 2 1 0.500 0.167 GO:0046933 MF 1 proton-transporting ATP synthase activity, rotational mechanism 1 P24539 22 1.34e-02 6 2 1 0.500 0.167 GO:0001672 BP 1 regulation of chromatin assembly or disassembly 1 Q86UE8 22 1.56e-02 7 2 1 0.500 0.143 GO:0030915 CC 1 Smc5-Smc6 complex 1 Q8N140 22 2.23e-02 10 2 1 0.500 0.100 GO:0071480 BP 1 cellular response to gamma radiation 1 Q86UE8 22 3.56e-02 16 2 1 0.500 0.062 GO:0032435 BP 1 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1 Q86UE8 22 3.58e-02 75 2 1 0.500 0.013 REAC:3108214 rea 1 SUMOylation of DNA damage response and repair proteins 1 Q8N140 22 3.79e-02 17 2 1 0.500 0.059 GO:0010332 BP 1 response to gamma radiation 1 Q86UE8 22 4.23e-02 19 2 1 0.500 0.053 GO:1901799 BP 1 negative regulation of proteasomal protein catabolic process 1 Q86UE8 22 4.72e-02 99 2 1 0.500 0.010 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 Q8N140 22 5.00e-02 720 2 2 1.000 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q86UE8,Q8N140 22 5.00e-02 105 2 1 0.500 0.010 REAC:2990846 rea 1 SUMOylation 1 Q8N140 23 1.66e-02 347 3 2 0.667 0.006 TF:M06902_0 tf 1 Factor: ZNF611; motif: NTTAKAAAAANC; match class: 0 1 Q00688,P23193 23 1.97e-02 11 3 1 0.333 0.091 TF:M06110_0 tf 1 Factor: Kox1; motif: NTKKATTGCCGC; match class: 0 1 Q00688 23 2.16e-02 397 3 2 0.667 0.005 TF:M07309_1 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 1 1 Q00688,Q9ULC4 23 2.86e-02 16 3 1 0.333 0.062 TF:M06236_0 tf 1 Factor: znf267; motif: NTGGGAAGGATA; match class: 0 1 Q9ULC4 23 2.99e-02 31 3 1 0.333 0.032 REAC:167243 rea 1 Tat-mediated HIV elongation arrest and recovery 1 P23193 23 2.99e-02 31 3 1 0.333 0.032 REAC:167238 rea 1 Pausing and recovery of Tat-mediated HIV elongation 1 P23193 23 3.09e-02 32 3 1 0.333 0.031 REAC:167287 rea 1 HIV elongation arrest and recovery 1 P23193 23 3.09e-02 32 3 1 0.333 0.031 REAC:167290 rea 1 Pausing and recovery of HIV elongation 1 P23193 23 3.28e-02 490 3 2 0.667 0.004 TF:M00070_0 tf 1 Factor: Tal-1beta:ITF-2; motif: NNNAACAGATGKTNNN; match class: 0 1 Q00688,Q9ULC4 23 3.28e-02 490 3 2 0.667 0.004 TF:M00066_0 tf 1 Factor: Tal-1alpha:E47; motif: NNNAACAGATGKTNNN; match class: 0 1 Q00688,Q9ULC4 23 3.86e-02 443 3 2 0.667 0.005 MI:hsa-miR-629 mi 1 MI:hsa-miR-629 1 Q00688,Q9ULC4 23 3.95e-02 448 3 2 0.667 0.004 MI:hsa-miR-151-3p mi 1 MI:hsa-miR-151-3p 1 Q00688,Q9ULC4 23 4.14e-02 43 3 1 0.333 0.023 REAC:167169 rea 1 HIV Transcription Elongation 1 P23193 23 4.14e-02 43 3 1 0.333 0.023 REAC:167200 rea 1 Formation of HIV-1 elongation complex containing HIV-1 Tat 1 P23193 23 4.14e-02 43 3 1 0.333 0.023 REAC:167246 rea 1 Tat-mediated elongation of the HIV-1 transcript 1 P23193 23 4.24e-02 44 3 1 0.333 0.023 REAC:167152 rea 1 Formation of HIV elongation complex in the absence of HIV Tat 1 P23193 23 4.29e-02 24 3 1 0.333 0.042 TF:M05699_0 tf 1 Factor: ZNF816A; motif: NGCWYAATAACA; match class: 0 1 Q00688 23 4.38e-02 7 3 1 0.333 0.143 GO:0032790 BP 1 ribosome disassembly 1 Q9ULC4 23 4.39e-02 473 3 2 0.667 0.004 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 Q00688,Q9ULC4 23 4.43e-02 475 3 2 0.667 0.004 MI:hsa-miR-590-3p mi 1 MI:hsa-miR-590-3p 1 Q00688,Q9ULC4 23 4.56e-02 482 3 2 0.667 0.004 MI:mmu-miR-464 mi 1 MI:mmu-miR-464 1 Q00688,Q9ULC4 23 4.64e-02 26 3 1 0.333 0.038 TF:M05461_0 tf 1 Factor: ZBTB4; motif: ATTTATGGCAC; match class: 0 1 Q9ULC4 23 4.82e-02 595 3 2 0.667 0.003 TF:M00065_0 tf 1 Factor: Tal-1beta:E47; motif: NNNAACAGATGKTNNN; match class: 0 1 Q00688,Q9ULC4 23 5.00e-02 8 3 1 0.333 0.125 GO:0001731 BP 1 formation of translation preinitiation complex 1 Q9ULC4 23 5.00e-02 505 3 2 0.667 0.004 MI:hsa-miR-548a-5p mi 1 MI:hsa-miR-548a-5p 1 Q00688,Q9ULC4 23 5.00e-02 28 3 1 0.333 0.036 TF:M06940_0 tf 1 Factor: ATF-3; motif: TCTATGTAATMW; match class: 0 1 Q9ULC4 24 1.19e-04 45 3 2 0.667 0.044 GO:0031338 BP 1 regulation of vesicle fusion 1 Q9Y3P9,B7ZAP0 24 1.36e-04 48 3 2 0.667 0.042 GO:1902017 BP 1 regulation of cilium assembly 1 Q9Y3P9,B7ZAP0 24 1.85e-04 56 3 2 0.667 0.036 GO:0090630 BP 1 activation of GTPase activity 1 Q9Y3P9,B7ZAP0 24 4.92e-04 91 3 2 0.667 0.022 GO:0017137 MF 1 Rab GTPase binding 1 Q9Y3P9,B7ZAP0 24 6.94e-04 108 3 2 0.667 0.019 GO:0060491 BP 1 regulation of cell projection assembly 1 Q9Y3P9,B7ZAP0 24 6.94e-04 108 3 2 0.667 0.019 GO:0006906 BP 1 vesicle fusion 1 Q9Y3P9,B7ZAP0 24 7.07e-04 109 3 2 0.667 0.018 GO:0090174 BP 1 organelle membrane fusion 1 Q9Y3P9,B7ZAP0 24 7.33e-04 111 3 2 0.667 0.018 GO:0043547 BP 1 positive regulation of GTPase activity 1 Q9Y3P9,B7ZAP0 24 1.01e-03 130 3 2 0.667 0.015 GO:1902115 BP 1 regulation of organelle assembly 1 Q9Y3P9,B7ZAP0 24 1.04e-03 132 3 2 0.667 0.015 GO:0044801 BP 1 single-organism membrane fusion 1 Q9Y3P9,B7ZAP0 24 1.20e-03 142 3 2 0.667 0.014 GO:0044782 BP 1 cilium organization 1 Q9Y3P9,B7ZAP0 24 1.27e-03 146 3 2 0.667 0.014 GO:0048284 BP 1 organelle fusion 1 Q9Y3P9,B7ZAP0 24 1.36e-03 151 3 2 0.667 0.013 GO:0043087 BP 1 regulation of GTPase activity 1 Q9Y3P9,B7ZAP0 24 1.47e-03 157 3 2 0.667 0.013 GO:0061025 BP 1 membrane fusion 1 Q9Y3P9,B7ZAP0 24 1.66e-03 167 3 2 0.667 0.012 GO:0005096 MF 1 GTPase activator activity 1 Q9Y3P9,B7ZAP0 24 1.70e-03 169 3 2 0.667 0.012 GO:0017016 MF 1 Ras GTPase binding 1 Q9Y3P9,B7ZAP0 24 2.01e-03 184 3 2 0.667 0.011 GO:0031267 MF 1 small GTPase binding 1 Q9Y3P9,B7ZAP0 24 2.26e-03 195 3 2 0.667 0.010 GO:0030695 MF 1 GTPase regulator activity 1 Q9Y3P9,B7ZAP0 24 2.40e-03 201 3 2 0.667 0.010 GO:0051020 MF 1 GTPase binding 1 Q9Y3P9,B7ZAP0 24 2.52e-03 206 3 2 0.667 0.010 GO:0060271 BP 1 cilium assembly 1 Q9Y3P9,B7ZAP0 24 2.93e-03 222 3 2 0.667 0.009 GO:0060589 MF 1 nucleoside-triphosphatase regulator activity 1 Q9Y3P9,B7ZAP0 24 3.36e-03 238 3 2 0.667 0.008 GO:0030031 BP 1 cell projection assembly 1 Q9Y3P9,B7ZAP0 24 4.68e-03 281 3 2 0.667 0.007 GO:0016050 BP 1 vesicle organization 1 Q9Y3P9,B7ZAP0 24 4.81e-03 285 3 2 0.667 0.007 GO:0060627 BP 1 regulation of vesicle-mediated transport 1 Q9Y3P9,B7ZAP0 24 5.05e-03 292 3 2 0.667 0.007 GO:0051345 BP 1 positive regulation of hydrolase activity 1 Q9Y3P9,B7ZAP0 24 5.22e-03 297 3 2 0.667 0.007 GO:0008047 MF 1 enzyme activator activity 1 Q9Y3P9,B7ZAP0 24 5.47e-03 304 3 2 0.667 0.007 GO:0031344 BP 1 regulation of cell projection organization 1 Q9Y3P9,B7ZAP0 24 1.16e-02 445 3 2 0.667 0.004 GO:0070925 BP 1 organelle assembly 1 Q9Y3P9,B7ZAP0 24 1.49e-02 504 3 2 0.667 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9Y3P9,B7ZAP0 24 1.50e-02 3 3 1 0.333 0.333 TF:M03935_0 tf 1 Factor: ZKSCAN3; motif: TGGKCTARCCTCGA; match class: 0 1 Q5TGL8 24 1.50e-02 506 3 2 0.667 0.004 GO:0051336 BP 1 regulation of hydrolase activity 1 Q9Y3P9,B7ZAP0 24 1.97e-02 582 3 2 0.667 0.003 GO:0030234 MF 1 enzyme regulator activity 1 Q9Y3P9,B7ZAP0 24 2.31e-02 630 3 2 0.667 0.003 GO:0044802 BP 1 single-organism membrane organization 1 Q9Y3P9,B7ZAP0 24 2.45e-02 650 3 2 0.667 0.003 GO:0030030 BP 1 cell projection organization 1 Q9Y3P9,B7ZAP0 24 2.53e-02 256 3 2 0.667 0.008 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q9Y3P9,B7ZAP0 24 2.61e-02 671 3 2 0.667 0.003 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q9Y3P9,B7ZAP0 24 2.89e-02 707 3 2 0.667 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q9Y3P9,B7ZAP0 24 2.91e-02 709 3 2 0.667 0.003 GO:0006886 BP 1 intracellular protein transport 1 Q9Y3P9,B7ZAP0 24 2.99e-02 6 3 1 0.333 0.167 TF:M06585_0 tf 1 Factor: ZNF479; motif: NGGTACTGMCKT; match class: 0 1 Q5TGL8 24 3.24e-02 749 3 2 0.667 0.003 GO:0061024 BP 1 membrane organization 1 Q9Y3P9,B7ZAP0 24 3.94e-02 828 3 2 0.667 0.002 GO:0098772 MF 1 molecular function regulator 1 Q9Y3P9,B7ZAP0 24 4.14e-02 850 3 2 0.667 0.002 GO:0044093 BP 1 positive regulation of molecular function 1 Q9Y3P9,B7ZAP0 24 4.49e-02 9 3 1 0.333 0.111 TF:M07310_1 tf 1 Factor: Sp5; motif: ACCSCGCCKCCSS; match class: 1 1 Q5TGL8 24 4.84e-02 355 3 2 0.667 0.006 TF:M04144_1 tf 1 Factor: TEAD3; motif: RCATTCCW; match class: 1 1 Q9Y3P9,Q5TGL8 24 5.00e-02 361 3 2 0.667 0.006 TF:M03829_1 tf 1 Factor: HNF-6; motif: AATCAATA; match class: 1 1 Q9Y3P9,B7ZAP0 24 5.00e-02 936 3 2 0.667 0.002 GO:0051049 BP 1 regulation of transport 1 Q9Y3P9,B7ZAP0 25 2.65e-08 2 2 2 1.000 1.000 GO:0047150 MF 1 betaine-homocysteine S-methyltransferase activity 1 Q9H2M3,Q93088 25 2.65e-07 5 2 2 1.000 0.400 GO:0008172 MF 1 S-methyltransferase activity 1 Q9H2M3,Q93088 25 1.19e-06 10 2 2 1.000 0.200 GO:0071267 BP 1 L-methionine salvage 1 Q9H2M3,Q93088 25 1.19e-06 10 2 2 1.000 0.200 GO:0043102 BP 1 amino acid salvage 1 Q9H2M3,Q93088 25 1.46e-06 11 2 2 1.000 0.182 GO:0006577 BP 1 amino-acid betaine metabolic process 1 Q9H2M3,Q93088 25 1.46e-06 11 2 2 1.000 0.182 GO:0046500 BP 1 S-adenosylmethionine metabolic process 1 Q9H2M3,Q93088 25 1.46e-06 11 2 2 1.000 0.182 GO:0071265 BP 1 L-methionine biosynthetic process 1 Q9H2M3,Q93088 25 2.41e-06 14 2 2 1.000 0.143 GO:0009086 BP 1 methionine biosynthetic process 1 Q9H2M3,Q93088 25 3.60e-06 17 2 2 1.000 0.118 GO:0000097 BP 1 sulfur amino acid biosynthetic process 1 Q9H2M3,Q93088 25 5.56e-06 21 2 2 1.000 0.095 GO:0006555 BP 1 methionine metabolic process 1 Q9H2M3,Q93088 25 6.69e-06 23 2 2 1.000 0.087 GO:0009067 BP 1 aspartate family amino acid biosynthetic process 1 Q9H2M3,Q93088 25 1.67e-05 36 2 2 1.000 0.056 GO:0043094 BP 1 cellular metabolic compound salvage 1 Q9H2M3,Q93088 25 1.67e-05 36 2 2 1.000 0.056 GO:0000096 BP 1 sulfur amino acid metabolic process 1 Q9H2M3,Q93088 25 2.13e-05 25 2 2 1.000 0.080 REAC:1614635 rea 1 Sulfur amino acid metabolism 1 Q9H2M3,Q93088 25 3.24e-05 50 2 2 1.000 0.040 GO:1901607 BP 1 alpha-amino acid biosynthetic process 1 Q9H2M3,Q93088 25 3.24e-05 50 2 2 1.000 0.040 GO:0009066 BP 1 aspartate family amino acid metabolic process 1 Q9H2M3,Q93088 25 4.84e-05 61 2 2 1.000 0.033 GO:0008652 BP 1 cellular amino acid biosynthetic process 1 Q9H2M3,Q93088 25 8.23e-05 43 2 2 1.000 0.047 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 Q9H2M3,Q93088 25 2.76e-04 145 2 2 1.000 0.014 GO:0008168 MF 1 methyltransferase activity 1 Q9H2M3,Q93088 25 3.05e-04 1 2 1 0.500 1.000 GO:0050666 BP 1 regulation of homocysteine metabolic process 1 Q93088 25 3.05e-04 1 2 1 0.500 1.000 GO:0061627 MF 1 S-methylmethionine-homocysteine S-methyltransferase activity 1 Q9H2M3 25 3.05e-04 1 2 1 0.500 1.000 GO:0008898 MF 1 S-adenosylmethionine-homocysteine S-methyltransferase activity 1 Q93088 25 3.05e-04 1 2 1 0.500 1.000 GO:0033477 BP 1 S-methylmethionine metabolic process 1 Q9H2M3 25 3.05e-04 1 2 1 0.500 1.000 GO:0031335 BP 1 regulation of sulfur amino acid metabolic process 1 Q93088 25 3.08e-04 153 2 2 1.000 0.013 GO:0016741 MF 1 transferase activity, transferring one-carbon groups 1 Q9H2M3,Q93088 25 3.12e-04 154 2 2 1.000 0.013 GO:1901605 BP 1 alpha-amino acid metabolic process 1 Q9H2M3,Q93088 25 3.49e-04 163 2 2 1.000 0.012 GO:0044272 BP 1 sulfur compound biosynthetic process 1 Q9H2M3,Q93088 25 3.76e-04 169 2 2 1.000 0.012 GO:0046394 BP 1 carboxylic acid biosynthetic process 1 Q9H2M3,Q93088 25 3.76e-04 169 2 2 1.000 0.012 GO:0016053 BP 1 organic acid biosynthetic process 1 Q9H2M3,Q93088 25 6.03e-04 214 2 2 1.000 0.009 GO:0006732 BP 1 coenzyme metabolic process 1 Q9H2M3,Q93088 25 6.32e-04 219 2 2 1.000 0.009 GO:0008270 MF 1 zinc ion binding 1 Q9H2M3,Q93088 25 9.40e-04 267 2 2 1.000 0.007 GO:0051186 BP 1 cofactor metabolic process 1 Q9H2M3,Q93088 25 1.06e-03 283 2 2 1.000 0.007 GO:0006520 BP 1 cellular amino acid metabolic process 1 Q9H2M3,Q93088 25 1.09e-03 287 2 2 1.000 0.007 GO:0006790 BP 1 sulfur compound metabolic process 1 Q9H2M3,Q93088 25 1.20e-03 375 2 2 1.000 0.005 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 Q9H2M3,Q93088 25 1.22e-03 304 2 2 1.000 0.007 GO:0044283 BP 1 small molecule biosynthetic process 1 Q9H2M3,Q93088 25 1.30e-03 314 2 2 1.000 0.006 GO:0046914 MF 1 transition metal ion binding 1 Q9H2M3,Q93088 25 1.83e-03 6 2 1 0.500 0.167 GO:0042426 BP 1 choline catabolic process 1 Q93088 25 2.14e-03 7 2 1 0.500 0.143 GO:0019695 BP 1 choline metabolic process 1 Q93088 25 2.67e-03 17 2 1 0.500 0.059 TF:M06774_0 tf 1 Factor: ZNF629; motif: NWAATAAGMATA; match class: 0 1 Q93088 25 2.75e-03 9 2 1 0.500 0.111 GO:0050667 BP 1 homocysteine metabolic process 1 Q93088 25 3.08e-03 6 2 1 0.500 0.167 REAC:6798163 rea 1 Choline catabolism 1 Q93088 25 3.70e-03 323 2 2 1.000 0.006 REAC:71291 rea 1 Metabolism of amino acids and derivatives 1 Q9H2M3,Q93088 25 4.64e-03 593 2 2 1.000 0.003 GO:0046872 MF 1 metal ion binding 1 Q9H2M3,Q93088 25 5.02e-03 32 2 1 0.500 0.031 TF:M05971_0 tf 1 Factor: ZNF860; motif: NTGGMCGAAAGA; match class: 0 1 Q9H2M3 25 5.18e-03 17 2 1 0.500 0.059 GO:0042762 BP 1 regulation of sulfur metabolic process 1 Q93088 25 5.49e-03 18 2 1 0.500 0.056 GO:0042402 BP 1 cellular biogenic amine catabolic process 1 Q93088 25 5.58e-03 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q9H2M3,Q93088 25 5.65e-03 654 2 2 1.000 0.003 GO:0043169 MF 1 cation binding 1 Q9H2M3,Q93088 25 5.79e-03 19 2 1 0.500 0.053 GO:0009310 BP 1 amine catabolic process 1 Q93088 25 6.70e-03 1042 2 2 1.000 0.002 TF:M00672_0 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 0 1 Q9H2M3,Q93088 25 7.02e-03 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 Q9H2M3,Q93088 25 7.16e-03 914 2 2 1.000 0.002 HPA:040020_10 hpa 1 soft tissue 2; chondrocytes[Supportive,Not detected] 1 Q9H2M3,Q93088 25 7.22e-03 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 Q9H2M3,Q93088 25 8.18e-03 977 2 2 1.000 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q9H2M3,Q93088 25 8.84e-03 1197 2 2 1.000 0.002 TF:M04405_0 tf 1 Factor: MSX1; motif: NCAATTAN; match class: 0 1 Q9H2M3,Q93088 25 9.25e-03 59 2 1 0.500 0.017 TF:M04046_0 tf 1 Factor: MYBL2; motif: AACSGTTAACSGNY; match class: 0 1 Q93088 25 9.57e-03 851 2 2 1.000 0.002 GO:0044711 BP 1 single-organism biosynthetic process 1 Q9H2M3,Q93088 25 1.04e-02 34 2 1 0.500 0.029 GO:0006576 BP 1 cellular biogenic amine metabolic process 1 Q93088 25 1.05e-02 1108 2 2 1.000 0.002 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 Q9H2M3,Q93088 25 1.23e-02 965 2 2 1.000 0.002 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q9H2M3,Q93088 25 1.44e-02 92 2 1 0.500 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 Q93088 25 1.47e-02 94 2 1 0.500 0.011 TF:M06523_0 tf 1 Factor: ZNF527; motif: KGGAGWATGCGM; match class: 0 1 Q93088 25 1.51e-02 1329 2 2 1.000 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 Q9H2M3,Q93088 25 1.61e-02 53 2 1 0.500 0.019 GO:0006521 BP 1 regulation of cellular amino acid metabolic process 1 Q93088 25 1.70e-02 37 2 1 0.500 0.027 KEGG:00260 keg 1 Glycine, serine and threonine metabolism 1 Q93088 25 1.71e-02 56 2 1 0.500 0.018 GO:0033238 BP 1 regulation of cellular amine metabolic process 1 Q93088 25 1.86e-02 119 2 1 0.500 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 Q93088 25 1.88e-02 120 2 1 0.500 0.008 TF:M05297_0 tf 1 Factor: Sox-1; motif: TRAATATTWAA; match class: 0 1 Q9H2M3 25 1.97e-02 1785 2 2 1.000 0.001 TF:M00626_1 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 1 1 Q9H2M3,Q93088 25 2.20e-02 1291 2 2 1.000 0.002 GO:0043167 MF 1 ion binding 1 Q9H2M3,Q93088 25 2.35e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 Q9H2M3,Q93088 25 2.55e-02 84 2 1 0.500 0.012 GO:0044106 BP 1 cellular amine metabolic process 1 Q93088 25 2.68e-02 172 2 1 0.500 0.006 TF:M01204_0 tf 1 Factor: Spi-B; motif: AAAAWGMGGAAGTWNSN; match class: 0 1 Q9H2M3 25 2.74e-02 90 2 1 0.500 0.011 GO:0009308 BP 1 amine metabolic process 1 Q93088 25 2.86e-02 94 2 1 0.500 0.011 GO:0006479 BP 1 protein methylation 1 Q93088 25 2.86e-02 94 2 1 0.500 0.011 GO:0008213 BP 1 protein alkylation 1 Q93088 25 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 Q9H2M3,Q93088 25 3.14e-02 2255 2 2 1.000 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 Q9H2M3,Q93088 25 3.24e-02 1565 2 2 1.000 0.001 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q9H2M3,Q93088 25 3.28e-02 108 2 1 0.500 0.009 GO:0097164 BP 1 ammonium ion metabolic process 1 Q93088 25 3.28e-02 108 2 1 0.500 0.009 GO:0010565 BP 1 regulation of cellular ketone metabolic process 1 Q93088 25 3.52e-02 116 2 1 0.500 0.009 GO:0006575 BP 1 cellular modified amino acid metabolic process 1 Q9H2M3 25 3.64e-02 2060 2 2 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 Q9H2M3,Q93088 25 3.67e-02 121 2 1 0.500 0.008 GO:0008757 MF 1 S-adenosylmethionine-dependent methyltransferase activity 1 Q93088 25 3.68e-02 2072 2 2 1.000 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 Q9H2M3,Q93088 25 3.78e-02 243 2 1 0.500 0.004 TF:M05454_0 tf 1 Factor: ZBTB3; motif: KGGTKYCAAC; match class: 0 1 Q9H2M3 25 3.89e-02 1715 2 2 1.000 0.001 GO:0016740 MF 1 transferase activity 1 Q9H2M3,Q93088 25 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 Q9H2M3,Q93088 25 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q9H2M3,Q93088 25 4.19e-02 2605 2 2 1.000 0.001 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 Q9H2M3,Q93088 25 4.31e-02 142 2 1 0.500 0.007 GO:0042180 BP 1 cellular ketone metabolic process 1 Q93088 25 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 Q93088 25 4.49e-02 2697 2 2 1.000 0.001 TF:M07046_0 tf 1 Factor: LEF-1; motif: ANNWWCAAAGN; match class: 0 1 Q9H2M3,Q93088 25 4.54e-02 292 2 1 0.500 0.003 TF:M05837_0 tf 1 Factor: ZFP2; motif: NCCWCGGGRATA; match class: 0 1 Q93088 25 4.62e-02 2737 2 2 1.000 0.001 TF:M01255_0 tf 1 Factor: ipf1; motif: RNWCATTAANWN; match class: 0 1 Q9H2M3,Q93088 25 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 Q93088 25 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q93088 25 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q9H2M3,Q93088 25 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q9H2M3,Q93088 25 4.97e-02 2837 2 2 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 Q9H2M3,Q93088 25 4.97e-02 2837 2 2 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 Q9H2M3,Q93088 25 5.00e-02 165 2 1 0.500 0.006 GO:0043414 BP 1 macromolecule methylation 1 Q93088 25 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 Q9H2M3,Q93088 25 5.00e-02 98 2 1 0.500 0.010 REAC:1483206 rea 1 Glycerophospholipid biosynthesis 1 Q93088 26 2.18e-03 1 2 1 0.500 1.000 GO:0070364 MF 1 mitochondrial heavy strand promoter sense binding 1 P36776 26 2.18e-03 1 2 1 0.500 1.000 GO:0070362 MF 1 mitochondrial heavy strand promoter anti-sense binding 1 P36776 26 2.18e-03 1 2 1 0.500 1.000 GO:0070407 BP 1 oxidation-dependent protein catabolic process 1 P36776 26 2.18e-03 1 2 1 0.500 1.000 GO:0070361 MF 1 mitochondrial light strand promoter anti-sense binding 1 P36776 26 4.35e-03 2 2 1 0.500 0.500 GO:0070363 MF 1 mitochondrial light strand promoter sense binding 1 P36776 26 1.00e-02 2 2 1 0.500 0.500 HP:0005242 hp 1 Extrahepatic biliary duct atresia 1 P36776 26 1.31e-02 6 2 1 0.500 0.167 GO:0051880 MF 1 G-quadruplex DNA binding 1 P36776 26 1.31e-02 6 2 1 0.500 0.167 GO:0004176 MF 1 ATP-dependent peptidase activity 1 P36776 26 1.50e-02 3 2 1 0.500 0.333 HP:0002682 hp 1 Broad skull 1 P36776 26 2.00e-02 4 2 1 0.500 0.250 HP:0003177 hp 1 Squared iliac bones 1 P36776 26 2.39e-02 11 2 1 0.500 0.091 GO:0070182 MF 1 DNA polymerase binding 1 P36776 26 2.61e-02 12 2 1 0.500 0.083 GO:0051131 BP 1 chaperone-mediated protein complex assembly 1 P36776 26 2.61e-02 12 2 1 0.500 0.083 GO:0032042 BP 1 mitochondrial DNA metabolic process 1 P36776 26 3.50e-02 7 2 1 0.500 0.143 HP:0001604 hp 1 Vocal cord paresis 1 P36776 26 4.00e-02 8 2 1 0.500 0.125 HP:0003417 hp 1 Coronal cleft vertebrae 1 P36776 26 4.35e-02 20 2 1 0.500 0.050 GO:0000002 BP 1 mitochondrial genome maintenance 1 P36776 26 4.50e-02 9 2 1 0.500 0.111 HP:0000143 hp 1 Rectovaginal fistula 1 P36776 26 5.00e-02 10 2 1 0.500 0.100 HP:0100590 hp 1 Rectal fistula 1 P36776 26 5.00e-02 357 2 2 1.000 0.006 MI:hsa-miR-149 mi 1 MI:hsa-miR-149 1 Q32P51,P36776 26 5.00e-02 10 2 1 0.500 0.100 HP:0100255 hp 1 Metaphyseal dysplasia 1 P36776 26 5.00e-02 10 2 1 0.500 0.100 HP:0001216 hp 1 Delayed ossification of carpal bones 1 P36776 26 5.00e-02 277 2 2 1.000 0.007 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q32P51,P36776 26 5.00e-02 23 2 1 0.500 0.043 GO:0043531 MF 1 ADP binding 1 P36776 26 5.00e-02 1 2 1 0.500 1.000 OMIM:600373 omi 1 CODAS SYNDROME;;CEREBRAL, OCULAR, DENTAL, AURICULAR, AND SKELETAL ANOMALIES SYNDROME 1 P36776 26 5.00e-02 23 2 1 0.500 0.043 GO:0006515 BP 1 misfolded or incompletely synthesized protein catabolic process 1 P36776 26 5.00e-02 10 2 1 0.500 0.100 HP:0004320 hp 1 Vaginal fistula 1 P36776 26 5.00e-02 128 2 1 0.500 0.008 KEGG:03040 keg 1 Spliceosome 1 Q32P51 27 8.44e-08 26 4 3 0.750 0.115 GO:1903513 BP 1 endoplasmic reticulum to cytosol transport 1 Q96DZ1,Q9UBV2,Q13438 27 8.44e-08 26 4 3 0.750 0.115 GO:0030970 BP 1 retrograde protein transport, ER to cytosol 1 Q96DZ1,Q9UBV2,Q13438 27 2.74e-07 38 4 3 0.750 0.079 GO:0032527 BP 1 protein exit from endoplasmic reticulum 1 Q96DZ1,Q9UBV2,Q13438 27 1.57e-06 54 4 3 0.750 0.056 REAC:5387390 rea 1 Hh mutants abrogate ligand secretion 1 Q96DZ1,Q9UBV2,Q13438 27 1.57e-06 54 4 3 0.750 0.056 REAC:5362768 rea 1 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 1 Q96DZ1,Q9UBV2,Q13438 27 1.87e-06 5 4 2 0.500 0.400 GO:0000836 CC 1 Hrd1p ubiquitin ligase complex 1 Q9UBV2,Q13438 27 1.95e-06 58 4 3 0.750 0.052 REAC:5358346 rea 1 Hedgehog ligand biogenesis 1 Q96DZ1,Q9UBV2,Q13438 27 2.06e-06 59 4 3 0.750 0.051 REAC:5678895 rea 1 Defective CFTR causes cystic fibrosis 1 Q96DZ1,Q9UBV2,Q13438 27 2.63e-06 64 4 3 0.750 0.047 REAC:5619084 rea 1 ABC transporter disorders 1 Q96DZ1,Q9UBV2,Q13438 27 2.81e-06 6 4 2 0.500 0.333 GO:0000835 CC 1 ER ubiquitin ligase complex 1 Q9UBV2,Q13438 27 2.86e-06 82 4 3 0.750 0.037 GO:0036503 BP 1 ERAD pathway 1 Q96DZ1,Q9UBV2,Q13438 27 3.17e-06 68 4 3 0.750 0.044 REAC:5619115 rea 1 Disorders of transmembrane transporters 1 Q96DZ1,Q9UBV2,Q13438 27 3.93e-06 7 4 2 0.500 0.286 GO:0070862 BP 1 negative regulation of protein exit from endoplasmic reticulum 1 Q96DZ1,Q13438 27 3.93e-06 7 4 2 0.500 0.286 GO:1904153 BP 1 negative regulation of retrograde protein transport, ER to cytosol 1 Q96DZ1,Q13438 27 8.43e-06 10 4 2 0.500 0.200 GO:1904293 BP 1 negative regulation of ERAD pathway 1 Q96DZ1,Q13438 27 8.43e-06 10 4 2 0.500 0.200 GO:1904380 BP 1 endoplasmic reticulum mannose trimming 1 Q9UBV2,Q13438 27 8.43e-06 10 4 2 0.500 0.200 GO:0000153 CC 1 cytoplasmic ubiquitin ligase complex 1 Q9UBV2,Q13438 27 1.02e-05 100 4 3 0.750 0.030 REAC:382556 rea 1 ABC-family proteins mediated transport 1 Q96DZ1,Q9UBV2,Q13438 27 1.03e-05 11 4 2 0.500 0.182 GO:1904152 BP 1 regulation of retrograde protein transport, ER to cytosol 1 Q96DZ1,Q13438 27 1.46e-05 13 4 2 0.500 0.154 GO:0036508 BP 1 protein alpha-1,2-demannosylation 1 Q9UBV2,Q13438 27 1.46e-05 13 4 2 0.500 0.154 GO:0036507 BP 1 protein demannosylation 1 Q9UBV2,Q13438 27 1.90e-05 123 4 3 0.750 0.024 REAC:5358351 rea 1 Signaling by Hedgehog 1 Q96DZ1,Q9UBV2,Q13438 27 2.55e-05 17 4 2 0.500 0.118 GO:0070861 BP 1 regulation of protein exit from endoplasmic reticulum 1 Q96DZ1,Q13438 27 3.92e-05 19 4 2 0.500 0.105 REAC:901032 rea 1 ER Quality Control Compartment (ERQC) 1 Q9UBV2,Q13438 27 4.73e-05 23 4 2 0.500 0.087 GO:0006517 BP 1 protein deglycosylation 1 Q9UBV2,Q13438 27 4.81e-05 209 4 3 0.750 0.014 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 Q96DZ1,Q9UBV2,Q13438 27 5.16e-05 24 4 2 0.500 0.083 GO:1904292 BP 1 regulation of ERAD pathway 1 Q96DZ1,Q13438 27 6.08e-05 26 4 2 0.500 0.077 GO:1903573 BP 1 negative regulation of response to endoplasmic reticulum stress 1 Q96DZ1,Q13438 27 6.32e-05 24 4 2 0.500 0.083 REAC:901042 rea 1 Calnexin/calreticulin cycle 1 Q9UBV2,Q13438 27 1.21e-04 33 4 2 0.500 0.061 REAC:532668 rea 1 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 1 Q9UBV2,Q13438 27 2.97e-04 57 4 2 0.500 0.035 GO:0090317 BP 1 negative regulation of intracellular protein transport 1 Q96DZ1,Q13438 27 3.00e-04 309 4 3 0.750 0.010 REAC:5663202 rea 1 Diseases of signal transduction 1 Q96DZ1,Q9UBV2,Q13438 27 3.19e-04 59 4 2 0.500 0.034 GO:0042177 BP 1 negative regulation of protein catabolic process 1 Q96DZ1,Q13438 27 3.41e-04 61 4 2 0.500 0.033 GO:0001948 MF 1 glycoprotein binding 1 Q96DZ1,Q13438 27 3.99e-04 66 4 2 0.500 0.030 GO:0032387 BP 1 negative regulation of intracellular transport 1 Q96DZ1,Q13438 27 4.11e-04 67 4 2 0.500 0.030 GO:0030433 BP 1 ER-associated ubiquitin-dependent protein catabolic process 1 Q9UBV2,Q13438 27 6.79e-04 86 4 2 0.500 0.023 GO:0009895 BP 1 negative regulation of catabolic process 1 Q96DZ1,Q13438 27 6.79e-04 86 4 2 0.500 0.023 GO:1903828 BP 1 negative regulation of cellular protein localization 1 Q96DZ1,Q13438 27 9.12e-04 560 4 3 0.750 0.005 GO:0030163 BP 1 protein catabolic process 1 Q96DZ1,Q9UBV2,Q13438 27 9.71e-04 572 4 3 0.750 0.005 GO:0044712 BP 1 single-organism catabolic process 1 Q96DZ1,Q9UBV2,Q13438 27 1.01e-03 105 4 2 0.500 0.019 GO:0051224 BP 1 negative regulation of protein transport 1 Q96DZ1,Q13438 27 1.17e-03 113 4 2 0.500 0.018 GO:1904950 BP 1 negative regulation of establishment of protein localization 1 Q96DZ1,Q13438 27 1.20e-03 493 4 3 0.750 0.006 REAC:382551 rea 1 Transmembrane transport of small molecules 1 Q96DZ1,Q9UBV2,Q13438 27 1.47e-03 658 4 3 0.750 0.005 GO:0044432 CC 1 endoplasmic reticulum part 1 Q96DZ1,Q9UBV2,Q13438 27 1.48e-03 127 4 2 0.500 0.016 GO:0005788 CC 1 endoplasmic reticulum lumen 1 Q96DZ1,Q13438 27 1.83e-03 709 4 3 0.750 0.004 GO:0006886 BP 1 intracellular protein transport 1 Q96DZ1,Q9UBV2,Q13438 27 2.16e-03 3 4 1 0.250 0.333 GO:0000839 CC 1 Hrd1p ubiquitin ligase ERAD-L complex 1 Q9UBV2 27 2.21e-03 2342 4 4 1.000 0.002 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q96DZ1,Q9UBV2,Q13438,Q68DX3 27 3.42e-03 876 4 3 0.750 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 Q96DZ1,Q9UBV2,Q13438 27 3.60e-03 5 4 1 0.250 0.200 GO:0006621 BP 1 protein retention in ER lumen 1 Q13438 27 3.65e-03 720 4 3 0.750 0.004 REAC:1643685 rea 1 Disease 1 Q96DZ1,Q9UBV2,Q13438 27 3.74e-03 285 4 2 0.500 0.007 MI:hsa-miR-18a* mi 1 MI:hsa-miR-18a* 1 Q13438,Q68DX3 27 4.12e-03 933 4 3 0.750 0.003 GO:0005783 CC 1 endoplasmic reticulum 1 Q96DZ1,Q9UBV2,Q13438 27 4.32e-03 6 4 1 0.250 0.167 GO:0035437 BP 1 maintenance of protein localization in endoplasmic reticulum 1 Q13438 27 4.44e-03 221 4 2 0.500 0.009 GO:0051051 BP 1 negative regulation of transport 1 Q96DZ1,Q13438 27 4.54e-03 964 4 3 0.750 0.003 GO:0015031 BP 1 protein transport 1 Q96DZ1,Q9UBV2,Q13438 27 4.64e-03 226 4 2 0.500 0.009 GO:0000151 CC 1 ubiquitin ligase complex 1 Q9UBV2,Q13438 27 5.04e-03 7 4 1 0.250 0.143 GO:0044322 CC 1 endoplasmic reticulum quality control compartment 1 Q96DZ1 27 5.05e-03 332 4 2 0.500 0.006 MI:hsa-miR-23a* mi 1 MI:hsa-miR-23a* 1 Q13438,Q68DX3 27 5.10e-03 237 4 2 0.500 0.008 GO:0033157 BP 1 regulation of intracellular protein transport 1 Q96DZ1,Q13438 27 6.45e-03 267 4 2 0.500 0.007 GO:0042176 BP 1 regulation of protein catabolic process 1 Q96DZ1,Q13438 27 6.68e-03 1100 4 3 0.750 0.003 GO:0045184 BP 1 establishment of protein localization 1 Q96DZ1,Q9UBV2,Q13438 27 6.72e-03 248 4 2 0.500 0.008 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q9UBV2,Q13438 27 6.88e-03 1111 4 3 0.750 0.003 GO:0034613 BP 1 cellular protein localization 1 Q96DZ1,Q9UBV2,Q13438 27 7.06e-03 1121 4 3 0.750 0.003 GO:0070727 BP 1 cellular macromolecule localization 1 Q96DZ1,Q9UBV2,Q13438 27 7.92e-03 11 4 1 0.250 0.091 GO:0036513 CC 1 Derlin-1 retrotranslocation complex 1 Q9UBV2 27 8.50e-03 307 4 2 0.500 0.007 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 Q9UBV2,Q13438 27 8.66e-03 310 4 2 0.500 0.006 GO:0032386 BP 1 regulation of intracellular transport 1 Q96DZ1,Q13438 27 8.87e-03 1212 4 3 0.750 0.002 GO:0033554 BP 1 cellular response to stress 1 Q96DZ1,Q9UBV2,Q13438 27 9.41e-03 1237 4 3 0.750 0.002 GO:0046907 BP 1 intracellular transport 1 Q96DZ1,Q9UBV2,Q13438 27 9.51e-03 325 4 2 0.500 0.006 GO:0010498 BP 1 proteasomal protein catabolic process 1 Q9UBV2,Q13438 27 9.93e-03 18 4 1 0.250 0.056 REAC:1912420 rea 1 Pre-NOTCH Processing in Golgi 1 Q9UBV2 27 1.06e-02 1290 4 3 0.750 0.002 GO:1901575 BP 1 organic substance catabolic process 1 Q96DZ1,Q9UBV2,Q13438 27 1.06e-02 486 4 2 0.500 0.004 MI:mmu-miR-465c-5p mi 1 MI:mmu-miR-465c-5p 1 Q13438,Q68DX3 27 1.08e-02 15 4 1 0.250 0.067 GO:0005545 MF 1 1-phosphatidylinositol binding 1 Q68DX3 27 1.08e-02 490 4 2 0.500 0.004 MI:mmu-miR-465b-5p mi 1 MI:mmu-miR-465b-5p 1 Q13438,Q68DX3 27 1.10e-02 350 4 2 0.500 0.006 GO:0009894 BP 1 regulation of catabolic process 1 Q96DZ1,Q13438 27 1.21e-02 368 4 2 0.500 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 Q96DZ1,Q13438 27 1.23e-02 1633 4 3 0.750 0.002 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q96DZ1,Q9UBV2,Q13438 27 1.24e-02 527 4 2 0.500 0.004 MI:hsa-miR-337-5p mi 1 MI:hsa-miR-337-5p 1 Q13438,Q68DX3 27 1.25e-02 1362 4 3 0.750 0.002 GO:0009056 BP 1 catabolic process 1 Q96DZ1,Q9UBV2,Q13438 27 1.29e-02 1377 4 3 0.750 0.002 GO:0071702 BP 1 organic substance transport 1 Q96DZ1,Q9UBV2,Q13438 27 1.33e-02 1393 4 3 0.750 0.002 GO:0008104 BP 1 protein localization 1 Q96DZ1,Q9UBV2,Q13438 27 1.33e-02 1394 4 3 0.750 0.002 GO:0010033 BP 1 response to organic substance 1 Q96DZ1,Q9UBV2,Q13438 27 1.36e-02 531 4 2 0.500 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q96DZ1,Q13438 27 1.46e-02 404 4 2 0.500 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q9UBV2,Q13438 27 1.46e-02 404 4 2 0.500 0.005 GO:0080135 BP 1 regulation of cellular response to stress 1 Q96DZ1,Q13438 27 1.48e-02 555 4 2 0.500 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 Q96DZ1,Q13438 27 1.48e-02 407 4 2 0.500 0.005 GO:0051223 BP 1 regulation of protein transport 1 Q96DZ1,Q13438 27 1.48e-02 408 4 2 0.500 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q9UBV2,Q13438 27 1.54e-02 416 4 2 0.500 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q9UBV2,Q13438 27 1.58e-02 22 4 1 0.250 0.045 GO:0072595 BP 1 maintenance of protein localization in organelle 1 Q13438 27 1.63e-02 1493 4 3 0.750 0.002 GO:0051649 BP 1 establishment of localization in cell 1 Q96DZ1,Q9UBV2,Q13438 27 1.67e-02 2 4 1 0.250 0.500 CORUM:5277 cor 1 HIF1A-OS9-EGLN3 complex 1 Q13438 27 1.76e-02 608 4 2 0.500 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q96DZ1,Q13438 27 1.87e-02 459 4 2 0.500 0.004 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q9UBV2,Q13438 27 1.93e-02 467 4 2 0.500 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 Q96DZ1,Q13438 27 2.01e-02 1941 4 3 0.750 0.002 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q96DZ1,Q13438,Q68DX3 27 2.05e-02 658 4 2 0.500 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 Q96DZ1,Q13438 27 2.05e-02 1618 4 3 0.750 0.002 GO:0033036 BP 1 macromolecule localization 1 Q96DZ1,Q9UBV2,Q13438 27 2.07e-02 484 4 2 0.500 0.004 GO:0044257 BP 1 cellular protein catabolic process 1 Q9UBV2,Q13438 27 2.08e-02 29 4 1 0.250 0.034 GO:0051220 BP 1 cytoplasmic sequestering of protein 1 Q13438 27 2.14e-02 1985 4 3 0.750 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q96DZ1,Q9UBV2,Q13438 27 2.15e-02 30 4 1 0.250 0.033 GO:0070830 BP 1 bicellular tight junction assembly 1 Q68DX3 27 2.29e-02 510 4 2 0.500 0.004 GO:0060341 BP 1 regulation of cellular localization 1 Q96DZ1,Q13438 27 2.31e-02 42 4 1 0.250 0.024 REAC:1912422 rea 1 Pre-NOTCH Expression and Processing 1 Q9UBV2 27 2.45e-02 528 4 2 0.500 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q9UBV2,Q13438 27 2.50e-02 730 4 2 0.500 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q96DZ1,Q13438 27 2.50e-02 3 4 1 0.250 0.333 CORUM:5276 cor 1 HIF1A-OS9-EGLN1 complex 1 Q13438 27 2.51e-02 534 4 2 0.500 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q9UBV2,Q13438 27 2.53e-02 4308 4 4 1.000 0.001 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 Q96DZ1,Q9UBV2,Q13438,Q68DX3 27 2.56e-02 540 4 2 0.500 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 Q96DZ1,Q13438 27 2.60e-02 544 4 2 0.500 0.004 GO:0032880 BP 1 regulation of protein localization 1 Q96DZ1,Q13438 27 2.65e-02 753 4 2 0.500 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q96DZ1,Q13438 27 2.65e-02 37 4 1 0.250 0.027 GO:0043297 BP 1 apical junction assembly 1 Q68DX3 27 2.67e-02 755 4 2 0.500 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q96DZ1,Q13438 27 2.87e-02 40 4 1 0.250 0.025 GO:0005923 CC 1 bicellular tight junction 1 Q68DX3 27 2.94e-02 41 4 1 0.250 0.024 GO:0070160 CC 1 occluding junction 1 Q68DX3 27 2.95e-02 1836 4 3 0.750 0.002 GO:0051641 BP 1 cellular localization 1 Q96DZ1,Q9UBV2,Q13438 27 3.17e-02 1882 4 3 0.750 0.002 GO:0042221 BP 1 response to chemical 1 Q96DZ1,Q9UBV2,Q13438 27 3.21e-02 607 4 2 0.500 0.003 GO:0051248 BP 1 negative regulation of protein metabolic process 1 Q96DZ1,Q13438 27 3.23e-02 836 4 2 0.500 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 Q96DZ1,Q13438 27 3.39e-02 624 4 2 0.500 0.003 GO:1990234 CC 1 transferase complex 1 Q9UBV2,Q13438 27 3.46e-02 1575 4 3 0.750 0.002 REAC:162582 rea 1 Signal Transduction 1 Q96DZ1,Q9UBV2,Q13438 27 3.50e-02 871 4 2 0.500 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 Q96DZ1,Q13438 27 3.54e-02 877 4 2 0.500 0.002 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q96DZ1,Q13438 27 3.79e-02 53 4 1 0.250 0.019 GO:0043296 CC 1 apical junction complex 1 Q68DX3 27 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q96DZ1,Q13438 27 3.94e-02 55 4 1 0.250 0.018 GO:0007043 BP 1 cell-cell junction assembly 1 Q68DX3 27 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q96DZ1,Q13438 27 4.15e-02 58 4 1 0.250 0.017 GO:0006641 BP 1 triglyceride metabolic process 1 Q9UBV2 27 4.16e-02 2071 4 3 0.750 0.001 GO:0006950 BP 1 response to stress 1 Q96DZ1,Q9UBV2,Q13438 27 4.18e-02 958 4 2 0.500 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q96DZ1,Q13438 27 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q96DZ1,Q13438 27 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q96DZ1,Q13438 27 4.49e-02 2582 4 3 0.750 0.001 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 Q96DZ1,Q13438,Q68DX3 27 4.54e-02 727 4 2 0.500 0.003 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q9UBV2,Q13438 27 4.93e-02 69 4 1 0.250 0.014 GO:0032507 BP 1 maintenance of protein location in cell 1 Q13438 27 5.00e-02 70 4 1 0.250 0.014 GO:0006638 BP 1 neutral lipid metabolic process 1 Q9UBV2 27 5.00e-02 6 4 1 0.250 0.167 CORUM:4999 cor 1 p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex 1 Q9UBV2 27 5.00e-02 70 4 1 0.250 0.014 GO:0051082 MF 1 unfolded protein binding 1 Q96DZ1 27 5.00e-02 152 4 3 0.750 0.020 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 Q96DZ1,Q9UBV2,Q13438 27 5.00e-02 497 4 3 0.750 0.006 TF:M00992_0 tf 1 Factor: FOXP3; motif: RWARTGTTGTTTCAKAC; match class: 0 1 Q9UBV2,Q13438,Q68DX3 27 5.00e-02 70 4 1 0.250 0.014 GO:0006639 BP 1 acylglycerol metabolic process 1 Q9UBV2 28 2.33e-02 7 2 1 0.500 0.143 GO:0004865 MF 1 protein serine/threonine phosphatase inhibitor activity 1 Q13522 28 2.55e-02 577 2 2 1.000 0.003 TF:M04064_0 tf 1 Factor: PAX5; motif: NGTCACGCWTSANTGMNY; match class: 0 1 Q13522,Q8N4L4 28 2.68e-02 592 2 2 1.000 0.003 TF:M01231_1 tf 1 Factor: ZNF515; motif: GTGGGGGGTM; match class: 1 1 Q13522,Q8N4L4 28 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 Q8N4L4 28 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 Q13522 28 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 Q13522 28 5.00e-02 59 2 1 0.500 0.017 KEGG:04720 keg 1 Long-term potentiation 1 Q13522 28 5.00e-02 808 2 2 1.000 0.002 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 Q13522,Q8N4L4 29 6.76e-03 23 2 1 0.500 0.043 TF:M00987_1 tf 1 Factor: FOXP1; motif: TTATTTGTRTTKKYTWKTWT; match class: 1 1 Q8IX12 29 7.35e-03 25 2 1 0.500 0.040 TF:M06496_0 tf 1 Factor: ZNF808; motif: KGGTAAAACCGM; match class: 0 1 Q8IX12 29 7.35e-03 25 2 1 0.500 0.040 TF:M06485_0 tf 1 Factor: ZNF808; motif: NGGKGAAATAGA; match class: 0 1 Q8IX12 29 7.65e-03 26 2 1 0.500 0.038 TF:M05712_0 tf 1 Factor: ZNF134; motif: NGGGGCGGCGGM; match class: 0 1 Q8IX12 29 7.67e-03 3 2 1 0.500 0.333 GO:0005606 CC 1 laminin-1 complex 1 P11047 29 7.67e-03 3 2 1 0.500 0.333 GO:0043259 CC 1 laminin-10 complex 1 P11047 29 7.67e-03 3 2 1 0.500 0.333 GO:0043260 CC 1 laminin-11 complex 1 P11047 29 1.23e-02 333 2 2 1.000 0.006 GO:0008284 BP 1 positive regulation of cell proliferation 1 Q8IX12,P11047 29 1.23e-02 42 2 1 0.500 0.024 TF:M03838_1 tf 1 Factor: Otx1; motif: WASTAATCC; match class: 1 1 P11047 29 1.28e-02 5 2 1 0.500 0.200 GO:0043256 CC 1 laminin complex 1 P11047 29 1.41e-02 48 2 1 0.500 0.021 TF:M03916_0 tf 1 Factor: PRDM1; motif: NRAAAGTGAAAGTNN; match class: 0 1 P11047 29 1.64e-02 56 2 1 0.500 0.018 TF:M05881_0 tf 1 Factor: ZNF676; motif: NGATTTGGGTGA; match class: 0 1 Q8IX12 29 1.65e-02 22 2 1 0.500 0.045 KEGG:05020 keg 1 Prion diseases 1 P11047 29 1.85e-02 63 2 1 0.500 0.016 TF:M06647_0 tf 1 Factor: ZNF665; motif: NGGKCTTKATGA; match class: 0 1 P11047 29 2.08e-02 71 2 1 0.500 0.014 TF:M05616_0 tf 1 Factor: ZNF73; motif: NCTTGGATCAKA; match class: 0 1 P11047 29 2.30e-02 9 2 1 0.500 0.111 GO:0005605 CC 1 basal lamina 1 P11047 29 2.34e-02 1422 2 2 1.000 0.001 TF:M01882_0 tf 1 Factor: IRF-2; motif: NNRAAAGTGAAASNNA; match class: 0 1 Q8IX12,P11047 29 2.37e-02 1663 2 2 1.000 0.001 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 Q8IX12,P11047 29 2.50e-02 5 2 1 0.500 0.200 CORUM:2318 cor 1 ITGA6-ITGB4-Laminin10/12 complex 1 P11047 29 2.50e-02 5 2 1 0.500 0.200 CORUM:2319 cor 1 ITGA6-ITGB4-Laminin10/12 complex 1 P11047 29 2.56e-02 10 2 1 0.500 0.100 GO:0031581 BP 1 hemidesmosome assembly 1 P11047 29 2.83e-02 1565 2 2 1.000 0.001 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 Q8IX12,P11047 29 2.90e-02 99 2 1 0.500 0.010 TF:M04188_0 tf 1 Factor: SREBF2; motif: ATCACGTGAY; match class: 0 1 Q8IX12 29 2.90e-02 99 2 1 0.500 0.010 TF:M04162_0 tf 1 Factor: BHLHE40; motif: NKCACGTGMC; match class: 0 1 Q8IX12 29 3.11e-02 106 2 1 0.500 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 P11047 29 3.57e-02 122 2 1 0.500 0.008 TF:M04178_0 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 0 1 Q8IX12 29 3.58e-02 1761 2 2 1.000 0.001 TF:M04437_1 tf 1 Factor: RHOXF1; motif: NTRATCCN; match class: 1 1 Q8IX12,P11047 29 4.10e-02 1883 2 2 1.000 0.001 TF:M04505_0 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 0 1 Q8IX12,P11047 29 4.10e-02 1883 2 2 1.000 0.001 TF:M04623_0 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 0 1 Q8IX12,P11047 29 4.10e-02 140 2 1 0.500 0.007 TF:M04091_0 tf 1 Factor: POU6F2; motif: GCTAATTANN; match class: 0 1 Q8IX12 29 4.16e-02 142 2 1 0.500 0.007 TF:M07048_0 tf 1 Factor: MafG; motif: CMATGACTCAGCAGA; match class: 0 1 P11047 29 4.30e-02 147 2 1 0.500 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 Q8IX12 29 4.41e-02 1953 2 2 1.000 0.001 TF:M00428_1 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 1 Q8IX12,P11047 29 4.45e-02 152 2 1 0.500 0.007 TF:M05756_0 tf 1 Factor: ZNF470; motif: NTGTTTAWKAWA; match class: 0 1 P11047 29 4.45e-02 152 2 1 0.500 0.007 TF:M02263_0 tf 1 Factor: NFE2L2; motif: RTGACWCAGCA; match class: 0 1 P11047 29 4.46e-02 1964 2 2 1.000 0.001 TF:M04325_1 tf 1 Factor: GSC2; motif: NNTAATCCNN; match class: 1 1 Q8IX12,P11047 29 4.53e-02 640 2 2 1.000 0.003 GO:0016477 BP 1 cell migration 1 Q8IX12,P11047 29 5.00e-02 23 2 1 0.500 0.043 REAC:3000157 rea 1 Laminin interactions 1 P11047 29 5.00e-02 67 2 1 0.500 0.015 KEGG:04512 keg 1 ECM-receptor interaction 1 P11047 29 5.00e-02 171 2 1 0.500 0.006 TF:M00926_1 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 1 1 P11047 29 5.00e-02 10 2 1 0.500 0.100 CORUM:5286 cor 1 TNF-alpha/NF-kappa B signaling complex 10 1 Q8IX12 29 5.00e-02 171 2 1 0.500 0.006 TF:M01267_1 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 1 1 P11047 29 5.00e-02 672 2 2 1.000 0.003 GO:0042127 BP 1 regulation of cell proliferation 1 Q8IX12,P11047 30 1.09e-06 7 2 2 1.000 0.286 GO:1900262 BP 1 regulation of DNA-directed DNA polymerase activity 1 Q9BVC3,P0CG13 30 1.09e-06 7 2 2 1.000 0.286 GO:0033170 MF 1 protein-DNA loading ATPase activity 1 Q9BVC3,P0CG13 30 1.09e-06 7 2 2 1.000 0.286 GO:1900264 BP 1 positive regulation of DNA-directed DNA polymerase activity 1 Q9BVC3,P0CG13 30 1.09e-06 7 2 2 1.000 0.286 GO:0003689 MF 1 DNA clamp loader activity 1 Q9BVC3,P0CG13 30 1.45e-06 8 2 2 1.000 0.250 GO:0031390 CC 1 Ctf18 RFC-like complex 1 Q9BVC3,P0CG13 30 4.05e-06 13 2 2 1.000 0.154 GO:0043142 MF 1 single-stranded DNA-dependent ATPase activity 1 Q9BVC3,P0CG13 30 3.09e-05 35 2 2 1.000 0.057 GO:0090329 BP 1 regulation of DNA-dependent DNA replication 1 Q9BVC3,P0CG13 30 5.38e-05 46 2 2 1.000 0.043 GO:2000573 BP 1 positive regulation of DNA biosynthetic process 1 Q9BVC3,P0CG13 30 1.22e-04 69 2 2 1.000 0.029 GO:2000278 BP 1 regulation of DNA biosynthetic process 1 Q9BVC3,P0CG13 30 1.29e-04 71 2 2 1.000 0.028 GO:0008094 MF 1 DNA-dependent ATPase activity 1 Q9BVC3,P0CG13 30 1.48e-04 76 2 2 1.000 0.026 GO:0006275 BP 1 regulation of DNA replication 1 Q9BVC3,P0CG13 30 3.65e-04 119 2 2 1.000 0.017 GO:0006261 BP 1 DNA-dependent DNA replication 1 Q9BVC3,P0CG13 30 4.22e-04 128 2 2 1.000 0.016 GO:0051054 BP 1 positive regulation of DNA metabolic process 1 Q9BVC3,P0CG13 30 5.05e-04 140 2 2 1.000 0.014 GO:0071897 BP 1 DNA biosynthetic process 1 Q9BVC3,P0CG13 30 1.22e-03 217 2 2 1.000 0.009 GO:0006260 BP 1 DNA replication 1 Q9BVC3,P0CG13 30 1.44e-03 236 2 2 1.000 0.008 GO:0051052 BP 1 regulation of DNA metabolic process 1 Q9BVC3,P0CG13 30 1.80e-03 3 2 1 0.500 0.333 GO:0034421 BP 1 post-translational protein acetylation 1 Q9BVC3 30 1.80e-03 264 2 2 1.000 0.008 GO:0042623 MF 1 ATPase activity, coupled 1 Q9BVC3,P0CG13 30 2.79e-03 592 2 2 1.000 0.003 MI:hsa-miR-518a-3p mi 1 MI:hsa-miR-518a-3p 1 Q9BVC3,P0CG13 30 3.25e-03 354 2 2 1.000 0.006 GO:0016887 MF 1 ATPase activity 1 Q9BVC3,P0CG13 30 3.94e-03 390 2 2 1.000 0.005 GO:0051347 BP 1 positive regulation of transferase activity 1 Q9BVC3,P0CG13 30 6.59e-03 11 2 1 0.500 0.091 GO:0034086 BP 1 maintenance of sister chromatid cohesion 1 Q9BVC3 30 6.59e-03 11 2 1 0.500 0.091 GO:0034088 BP 1 maintenance of mitotic sister chromatid cohesion 1 Q9BVC3 30 7.93e-03 553 2 2 1.000 0.004 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 Q9BVC3,P0CG13 30 8.28e-03 565 2 2 1.000 0.004 GO:0044427 CC 1 chromosomal part 1 Q9BVC3,P0CG13 30 8.34e-03 1 2 1 0.500 1.000 CORUM:2805 cor 1 CTF8-DCC1 subcomplex 1 Q9BVC3 30 8.63e-03 577 2 2 1.000 0.003 GO:0051338 BP 1 regulation of transferase activity 1 Q9BVC3,P0CG13 30 9.03e-03 590 2 2 1.000 0.003 GO:0016462 MF 1 pyrophosphatase activity 1 Q9BVC3,P0CG13 30 9.09e-03 592 2 2 1.000 0.003 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 Q9BVC3,P0CG13 30 9.09e-03 592 2 2 1.000 0.003 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Q9BVC3,P0CG13 30 9.62e-03 609 2 2 1.000 0.003 GO:0005694 CC 1 chromosome 1 Q9BVC3,P0CG13 30 1.16e-02 670 2 2 1.000 0.003 GO:0006259 BP 1 DNA metabolic process 1 Q9BVC3,P0CG13 30 1.17e-02 671 2 2 1.000 0.003 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q9BVC3,P0CG13 30 1.26e-02 21 2 1 0.500 0.048 GO:0007064 BP 1 mitotic sister chromatid cohesion 1 Q9BVC3 30 1.67e-02 2 2 1 0.500 0.500 CORUM:2806 cor 1 CTF8-CTF18-DCC1 subcomplex 1 Q9BVC3 30 1.67e-02 2 2 1 0.500 0.500 CORUM:612 cor 1 CTF18-CTF8-DCC1 complex 1 Q9BVC3 30 1.87e-02 850 2 2 1.000 0.002 GO:0044093 BP 1 positive regulation of molecular function 1 Q9BVC3,P0CG13 30 2.08e-02 896 2 2 1.000 0.002 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q9BVC3,P0CG13 30 2.09e-02 35 2 1 0.500 0.029 GO:0043687 BP 1 post-translational protein modification 1 Q9BVC3 30 2.21e-02 922 2 2 1.000 0.002 GO:0003677 MF 1 DNA binding 1 Q9BVC3,P0CG13 30 2.26e-02 933 2 2 1.000 0.002 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 Q9BVC3,P0CG13 30 2.37e-02 956 2 2 1.000 0.002 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q9BVC3,P0CG13 30 2.40e-02 12 2 1 0.500 0.083 TF:M05937_0 tf 1 Factor: ZNF582; motif: NKGGTATGAAGM; match class: 0 1 P0CG13 30 2.45e-02 971 2 2 1.000 0.002 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q9BVC3,P0CG13 30 2.50e-02 3 2 1 0.500 0.333 CORUM:613 cor 1 CTF18-CTF8-DCC1-RFC3 complex 1 Q9BVC3 30 2.56e-02 993 2 2 1.000 0.002 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q9BVC3,P0CG13 30 2.71e-02 588 2 2 1.000 0.003 TF:M01252_1 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 1 1 Q9BVC3,P0CG13 30 2.98e-02 1071 2 2 1.000 0.002 GO:0050790 BP 1 regulation of catalytic activity 1 Q9BVC3,P0CG13 30 3.40e-02 17 2 1 0.500 0.059 TF:M04331_0 tf 1 Factor: HESX1; motif: NTAATTGGYAATTAN; match class: 0 1 Q9BVC3 30 5.00e-02 25 2 1 0.500 0.040 TF:M03952_1 tf 1 Factor: CDP; motif: TRATCRATAN; match class: 1 1 Q9BVC3 30 5.00e-02 6 2 1 0.500 0.167 CORUM:2804 cor 1 CTF18-cohesion-RFC complex 1 Q9BVC3 30 5.00e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 Q9BVC3,P0CG13 31 1.77e-04 77 2 2 1.000 0.026 GO:0000922 CC 1 spindle pole 1 Q8TC44,Q9C0F1 31 9.09e-04 174 2 2 1.000 0.011 GO:0005819 CC 1 spindle 1 Q8TC44,Q9C0F1 31 4.18e-03 1 2 1 0.500 1.000 OMIM:615973 omi 1 CONE-ROD DYSTROPHY 20; CORD20 1 Q8TC44 31 5.04e-03 409 2 2 1.000 0.005 GO:0005813 CC 1 centrosome 1 Q8TC44,Q9C0F1 31 6.52e-03 872 2 2 1.000 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 Q8TC44,Q9C0F1 31 6.77e-03 474 2 2 1.000 0.004 GO:0005815 CC 1 microtubule organizing center 1 Q8TC44,Q9C0F1 31 1.26e-02 17 2 1 0.500 0.059 HP:0030493 hp 1 Abnormality of foveal pigmentation 1 Q8TC44 31 1.26e-02 17 2 1 0.500 0.059 HP:0008001 hp 1 Foveal hyperpigmentation 1 Q8TC44 31 1.34e-02 18 2 1 0.500 0.056 HP:0200056 hp 1 Macular scarring 1 Q8TC44 31 1.45e-02 13 2 1 0.500 0.077 TF:M06614_0 tf 1 Factor: ZNF594; motif: TGTTAAAAASGC; match class: 0 1 Q8TC44 31 1.48e-02 20 2 1 0.500 0.050 HP:0030478 hp 1 Abnormal amplitude of dark-adapted bright flash electroretinogram 1 Q8TC44 31 1.48e-02 20 2 1 0.500 0.050 HP:0030470 hp 1 Abnormal dark-adapted bright flash electroretinogram 1 Q8TC44 31 1.48e-02 20 2 1 0.500 0.050 HP:0007984 hp 1 Reduced amplitude of dark-adapted bright flash electroretinogram b-wave 1 Q8TC44 31 1.48e-02 20 2 1 0.500 0.050 HP:0030469 hp 1 Abnormal dark-adapted electroretinogram 1 Q8TC44 31 1.56e-02 21 2 1 0.500 0.048 HP:0007924 hp 1 Slow decrease in visual acuity 1 Q8TC44 31 1.60e-02 605 2 2 1.000 0.003 TF:M01967_0 tf 1 Factor: Pbx; motif: NKTGATTGACRKSN; match class: 0 1 Q8TC44,Q9C0F1 31 1.63e-02 22 2 1 0.500 0.045 HP:0011504 hp 1 Bull's eye maculopathy 1 Q8TC44 31 1.63e-02 1380 2 2 1.000 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q8TC44,Q9C0F1 31 1.78e-02 769 2 2 1.000 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 Q8TC44,Q9C0F1 31 2.00e-02 27 2 1 0.500 0.037 HP:0000493 hp 1 Abnormality of the fovea 1 Q8TC44 31 2.15e-02 29 2 1 0.500 0.034 HP:0009926 hp 1 Increased lacrimation 1 Q8TC44 31 2.63e-02 933 2 2 1.000 0.002 GO:0044430 CC 1 cytoskeletal part 1 Q8TC44,Q9C0F1 31 2.74e-02 37 2 1 0.500 0.027 HP:0008002 hp 1 Abnormality of macular pigmentation 1 Q8TC44 31 2.78e-02 25 2 1 0.500 0.040 TF:M06861_0 tf 1 Factor: ZNF484; motif: NGRTAGGGGAAA; match class: 0 1 Q8TC44 31 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 Q8TC44,Q9C0F1 31 2.99e-02 43 2 1 0.500 0.023 GO:0001895 BP 1 retina homeostasis 1 Q8TC44 31 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 Q8TC44,Q9C0F1 31 4.37e-02 1204 2 2 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 Q8TC44,Q9C0F1 31 4.38e-02 63 2 1 0.500 0.016 GO:0036064 CC 1 ciliary basal body 1 Q8TC44 31 4.42e-02 60 2 1 0.500 0.017 HP:0007994 hp 1 Peripheral visual field loss 1 Q8TC44 31 4.42e-02 60 2 1 0.500 0.017 HP:0008043 hp 1 Retinal arteriolar constriction 1 Q8TC44 31 4.43e-02 1007 2 2 1.000 0.002 TF:M03974_0 tf 1 Factor: ERF; motif: ACCGGAAGTR; match class: 0 1 Q8TC44,Q9C0F1 31 4.64e-02 63 2 1 0.500 0.016 HP:0012045 hp 1 Retinal flecks 1 Q8TC44 31 4.85e-02 66 2 1 0.500 0.015 HP:0000603 hp 1 Central scotoma 1 Q8TC44 31 4.85e-02 66 2 1 0.500 0.015 HP:0007843 hp 1 Attenuation of retinal blood vessels 1 Q8TC44 31 4.85e-02 66 2 1 0.500 0.015 HP:0007688 hp 1 Undetectable light- and dark-adapted electroretinogram 1 Q8TC44 31 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q9C0F1 31 5.00e-02 68 2 1 0.500 0.015 HP:0011003 hp 1 Severe Myopia 1 Q8TC44 31 5.00e-02 72 2 1 0.500 0.014 GO:0005814 CC 1 centriole 1 Q8TC44 31 5.00e-02 45 2 1 0.500 0.022 TF:M00095_1 tf 1 Factor: CDP; motif: CCAATAATCGAT; match class: 1 1 Q8TC44 31 5.00e-02 12 2 1 0.500 0.083 OMIM:120970 omi 1 Autosomal Cone-Rod Dystrophy 1 Q8TC44 32 1.97e-05 22 2 2 1.000 0.091 GO:0046540 CC 1 U4/U6 x U5 tri-snRNP complex 1 O43172,O43290 32 2.99e-05 27 2 2 1.000 0.074 GO:0097526 CC 1 spliceosomal tri-snRNP complex 1 O43172,O43290 32 4.78e-05 34 2 2 1.000 0.059 GO:0015030 CC 1 Cajal body 1 O43172,O43290 32 1.22e-04 54 2 2 1.000 0.037 GO:0097525 CC 1 spliceosomal snRNP complex 1 O43172,O43290 32 1.56e-04 61 2 2 1.000 0.033 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 O43172,O43290 32 6.75e-04 173 2 2 1.000 0.012 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 O43172,O43290 32 7.31e-04 180 2 2 1.000 0.011 REAC:72172 rea 1 mRNA Splicing 1 O43172,O43290 32 9.14e-04 147 2 2 1.000 0.014 GO:0005681 CC 1 spliceosomal complex 1 O43172,O43290 32 9.83e-04 1 2 1 0.500 1.000 GO:0000481 BP 1 maturation of 5S rRNA 1 O43290 32 1.17e-03 228 2 2 1.000 0.009 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 O43172,O43290 32 1.36e-03 179 2 2 1.000 0.011 GO:0016604 CC 1 nuclear body 1 O43172,O43290 32 1.96e-03 2 2 1 0.500 0.500 GO:0045583 BP 1 regulation of cytotoxic T cell differentiation 1 O43290 32 1.96e-03 2 2 1 0.500 0.500 GO:0045065 BP 1 cytotoxic T cell differentiation 1 O43290 32 1.96e-03 2 2 1 0.500 0.500 GO:0045585 BP 1 positive regulation of cytotoxic T cell differentiation 1 O43290 32 2.73e-03 564 2 2 1.000 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 O43172,O43290 32 2.95e-03 3 2 1 0.500 0.333 GO:0071001 CC 1 U4/U6 snRNP 1 O43172 32 2.98e-03 265 2 2 1.000 0.008 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 O43172,O43290 32 2.98e-03 265 2 2 1.000 0.008 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 O43172,O43290 32 3.07e-03 269 2 2 1.000 0.007 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 O43172,O43290 32 4.51e-03 326 2 2 1.000 0.006 GO:0008380 BP 1 RNA splicing 1 O43172,O43290 32 4.60e-03 733 2 2 1.000 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 O43172,O43290 32 4.91e-03 5 2 1 0.500 0.200 GO:0030621 MF 1 U4 snRNA binding 1 O43172 32 4.97e-03 342 2 2 1.000 0.006 GO:0006397 BP 1 mRNA processing 1 O43172,O43290 32 7.04e-03 906 2 2 1.000 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 O43172,O43290 32 7.54e-03 938 2 2 1.000 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 O43172,O43290 32 7.98e-03 965 2 2 1.000 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 O43172,O43290 32 8.49e-03 995 2 2 1.000 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 O43172,O43290 32 9.82e-03 10 2 1 0.500 0.100 GO:0017070 MF 1 U6 snRNA binding 1 O43172 32 1.15e-02 521 2 2 1.000 0.004 GO:0044451 CC 1 nucleoplasm part 1 O43172,O43290 32 1.16e-02 522 2 2 1.000 0.004 GO:0016071 BP 1 mRNA metabolic process 1 O43172,O43290 32 1.35e-02 1256 2 2 1.000 0.002 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 O43172,O43290 32 1.53e-02 599 2 2 1.000 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 O43172,O43290 32 1.53e-02 600 2 2 1.000 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 O43172,O43290 32 1.57e-02 16 2 1 0.500 0.062 GO:0045292 BP 1 mRNA cis splicing, via spliceosome 1 O43290 32 1.67e-02 1396 2 2 1.000 0.001 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 O43172,O43290 32 1.85e-02 1470 2 2 1.000 0.001 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 O43172,O43290 32 1.93e-02 1499 2 2 1.000 0.001 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 O43172,O43290 32 1.96e-02 1513 2 2 1.000 0.001 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 O43172,O43290 32 1.98e-02 1521 2 2 1.000 0.001 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 O43172,O43290 32 2.13e-02 1576 2 2 1.000 0.001 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 O43172,O43290 32 2.16e-02 22 2 1 0.500 0.045 GO:0045582 BP 1 positive regulation of T cell differentiation 1 O43290 32 2.36e-02 1659 2 2 1.000 0.001 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 O43172,O43290 32 2.39e-02 1670 2 2 1.000 0.001 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 O43172,O43290 32 2.41e-02 752 2 2 1.000 0.003 GO:0006396 BP 1 RNA processing 1 O43172,O43290 32 2.74e-02 1787 2 2 1.000 0.001 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 O43172,O43290 32 2.75e-02 28 2 1 0.500 0.036 GO:0045621 BP 1 positive regulation of lymphocyte differentiation 1 O43290 32 2.79e-02 1802 2 2 1.000 0.001 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 O43172,O43290 32 2.79e-02 1804 2 2 1.000 0.001 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 O43172,O43290 32 2.83e-02 1818 2 2 1.000 0.001 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 O43172,O43290 32 2.86e-02 1825 2 2 1.000 0.001 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 O43172,O43290 32 2.92e-02 7 2 1 0.500 0.143 TF:M05874_1 tf 1 Factor: ZNF564; motif: KGGWHGTGAACM; match class: 1 1 O43290 32 2.94e-02 160 2 1 0.500 0.006 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 O43172 32 2.96e-02 1857 2 2 1.000 0.001 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 O43172,O43290 32 3.04e-02 31 2 1 0.500 0.032 GO:0017069 MF 1 snRNA binding 1 O43172 32 3.05e-02 1885 2 2 1.000 0.001 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 O43172,O43290 32 3.18e-02 1924 2 2 1.000 0.001 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 O43172,O43290 32 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 O43172,O43290 32 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 O43172,O43290 32 3.42e-02 1998 2 2 1.000 0.001 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 O43172,O43290 32 3.53e-02 36 2 1 0.500 0.028 GO:0000387 BP 1 spliceosomal snRNP assembly 1 O43290 32 3.53e-02 36 2 1 0.500 0.028 GO:0045580 BP 1 regulation of T cell differentiation 1 O43290 32 3.54e-02 48 2 1 0.500 0.021 HP:0007830 hp 1 Adult-onset night blindness 1 O43172 32 3.54e-02 48 2 1 0.500 0.021 HP:0008028 hp 1 Cystoid macular degeneration 1 O43172 32 3.54e-02 48 2 1 0.500 0.021 HP:0200070 hp 1 Peripheral retinal atrophy 1 O43172 32 3.54e-02 48 2 1 0.500 0.021 HP:0007987 hp 1 Progressive visual field defects 1 O43172 32 3.60e-02 2049 2 2 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 O43172,O43290 32 3.61e-02 2051 2 2 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 O43172,O43290 32 3.61e-02 49 2 1 0.500 0.020 HP:0007950 hp 1 Peripapillary chorioretinal atrophy 1 O43172 32 3.68e-02 2072 2 2 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 O43172,O43290 32 3.69e-02 50 2 1 0.500 0.020 HP:0000552 hp 1 Tritanomaly 1 O43172 32 3.69e-02 50 2 1 0.500 0.020 HP:0011505 hp 1 Cystoid macular edema 1 O43172 32 3.69e-02 50 2 1 0.500 0.020 HP:0011519 hp 1 Anomalous trichromacy 1 O43172 32 3.73e-02 2086 2 2 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 O43172,O43290 32 3.76e-02 51 2 1 0.500 0.020 HP:0040049 hp 1 Macular edema 1 O43172 32 3.76e-02 51 2 1 0.500 0.020 HP:0000642 hp 1 Red-green dyschromatopsia 1 O43172 32 3.76e-02 51 2 1 0.500 0.020 HP:0007722 hp 1 Retinal pigment epithelial atrophy 1 O43172 32 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 O43172,O43290 32 3.83e-02 52 2 1 0.500 0.019 HP:0030498 hp 1 Macular thickening 1 O43172 32 3.83e-02 52 2 1 0.500 0.019 HP:0008020 hp 1 Progressive cone degeneration 1 O43172 32 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 O43172,O43290 32 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 O43172,O43290 32 3.91e-02 53 2 1 0.500 0.019 HP:0001146 hp 1 Pigmentary retinal degeneration 1 O43172 32 3.92e-02 2139 2 2 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 O43172,O43290 32 3.98e-02 2153 2 2 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 O43172,O43290 32 3.98e-02 54 2 1 0.500 0.019 HP:0007737 hp 1 Bone spicule pigmentation of the retina 1 O43172 32 3.98e-02 2154 2 2 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 O43172,O43290 32 4.00e-02 2159 2 2 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 O43172,O43290 32 4.05e-02 221 2 1 0.500 0.005 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 O43172 32 4.11e-02 2188 2 2 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 O43172,O43290 32 4.13e-02 56 2 1 0.500 0.018 HP:0001099 hp 1 Fundus atrophy 1 O43172 32 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 O43172,O43290 32 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 O43172,O43290 32 4.19e-02 2209 2 2 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 O43172,O43290 32 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 O43172,O43290 32 4.25e-02 2227 2 2 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 O43172,O43290 32 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 O43172,O43290 32 4.27e-02 58 2 1 0.500 0.017 HP:0007787 hp 1 Posterior subcapsular cataract 1 O43172 32 4.27e-02 58 2 1 0.500 0.017 HP:0002527 hp 1 Falls 1 O43172 32 4.34e-02 59 2 1 0.500 0.017 HP:0007641 hp 1 Dyschromatopsia 1 O43172 32 4.34e-02 59 2 1 0.500 0.017 HP:0000622 hp 1 Blurred vision 1 O43172 32 4.42e-02 60 2 1 0.500 0.017 HP:0001115 hp 1 Posterior polar cataract 1 O43172 32 4.42e-02 60 2 1 0.500 0.017 HP:0008043 hp 1 Retinal arteriolar constriction 1 O43172 32 4.42e-02 60 2 1 0.500 0.017 HP:0007994 hp 1 Peripheral visual field loss 1 O43172 32 4.42e-02 60 2 1 0.500 0.017 HP:0007894 hp 1 Hypopigmentation of the fundus 1 O43172 32 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 O43172,O43290 32 4.44e-02 2274 2 2 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 O43172,O43290 32 4.44e-02 2274 2 2 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 O43172,O43290 32 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 O43172,O43290 32 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 O43172,O43290 32 4.63e-02 513 2 2 1.000 0.004 MI:hsa-miR-20b mi 1 MI:hsa-miR-20b 1 O43172,O43290 32 4.64e-02 63 2 1 0.500 0.016 HP:0012045 hp 1 Retinal flecks 1 O43172 32 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 O43172,O43290 32 4.71e-02 48 2 1 0.500 0.021 GO:0045619 BP 1 regulation of lymphocyte differentiation 1 O43290 32 4.71e-02 64 2 1 0.500 0.016 HP:0001105 hp 1 Retinal atrophy 1 O43172 32 4.78e-02 65 2 1 0.500 0.015 HP:0000523 hp 1 Subcapsular cataract 1 O43172 32 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 O43172,O43290 32 4.85e-02 66 2 1 0.500 0.015 HP:0007688 hp 1 Undetectable light- and dark-adapted electroretinogram 1 O43172 32 4.85e-02 66 2 1 0.500 0.015 HP:0007843 hp 1 Attenuation of retinal blood vessels 1 O43172 32 4.85e-02 66 2 1 0.500 0.015 HP:0000603 hp 1 Central scotoma 1 O43172 32 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 O43172,O43290 32 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 O43172,O43290 32 4.93e-02 67 2 1 0.500 0.015 HP:0040214 hp 1 Abnormal insulin level 1 O43172 32 4.93e-02 67 2 1 0.500 0.015 HP:0040215 hp 1 Abnormal circulating insulin level 1 O43172 32 4.93e-02 67 2 1 0.500 0.015 HP:0000842 hp 1 Hyperinsulinemia 1 O43172 32 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 O43172,O43290 32 5.00e-02 128 2 2 1.000 0.016 KEGG:03040 keg 1 Spliceosome 1 O43172,O43290 32 5.00e-02 1485 2 2 1.000 0.001 REAC:74160 rea 1 Gene Expression 1 O43172,O43290 32 5.00e-02 12 2 1 0.500 0.083 TF:M06228_0 tf 1 Factor: ZNF543; motif: KGGWATRTGGGA; match class: 0 1 O43290 32 5.00e-02 533 2 2 1.000 0.004 MI:hsa-miR-17 mi 1 MI:hsa-miR-17 1 O43172,O43290 32 5.00e-02 141 2 2 1.000 0.014 CORUM:351 cor 1 Spliceosome 1 O43172,O43290 32 5.00e-02 51 2 1 0.500 0.020 GO:1902107 BP 1 positive regulation of leukocyte differentiation 1 O43290 32 5.00e-02 1 2 1 0.500 1.000 OMIM:615922 omi 1 RETINITIS PIGMENTOSA 70; RP70 1 O43172 33 1.18e-05 8 4 2 0.500 0.250 GO:0031209 CC 1 SCAR complex 1 Q8IZP0,Q8WUW1 33 3.26e-04 5 4 2 0.500 0.400 CORUM:186 cor 1 Wave-2 complex 1 Q8IZP0,Q8WUW1 33 5.85e-04 36 4 2 0.500 0.056 REAC:5663213 rea 1 RHO GTPases Activate WASPs and WAVEs 1 Q8IZP0,Q8WUW1 33 9.57e-04 68 4 2 0.500 0.029 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 Q8IZP0,Q8WUW1 33 9.57e-04 68 4 2 0.500 0.029 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 Q8IZP0,Q8WUW1 33 9.57e-04 68 4 2 0.500 0.029 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 Q8IZP0,Q8WUW1 33 1.01e-03 70 4 2 0.500 0.029 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 Q8IZP0,Q8WUW1 33 1.04e-03 71 4 2 0.500 0.028 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 Q8IZP0,Q8WUW1 33 1.58e-03 59 4 2 0.500 0.034 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 Q8IZP0,Q8WUW1 33 1.68e-03 90 4 2 0.500 0.022 GO:0030027 CC 1 lamellipodium 1 Q8IZP0,Q8WUW1 33 1.79e-03 2618 4 4 1.000 0.002 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.11e-03 242 4 2 0.500 0.008 TF:M01009_1 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 1 1 Q70E73,Q6T4R5 33 2.28e-03 252 4 2 0.500 0.008 TF:M01220_0 tf 1 Factor: STAT3:STAT3; motif: TTKMCGGGAAMTSC; match class: 0 1 Q70E73,Q8WUW1 33 2.83e-03 117 4 2 0.500 0.017 GO:0008154 BP 1 actin polymerization or depolymerization 1 Q8IZP0,Q8WUW1 33 2.99e-03 81 4 2 0.500 0.025 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 Q8IZP0,Q8WUW1 33 2.99e-03 289 4 2 0.500 0.007 TF:M05950_0 tf 1 Factor: ZNF700; motif: NSGWGTARTTCS; match class: 0 1 Q8IZP0,Q70E73 33 4.17e-03 142 4 2 0.500 0.014 GO:0006909 BP 1 phagocytosis 1 Q8IZP0,Q8WUW1 33 5.62e-03 165 4 2 0.500 0.012 GO:0038093 BP 1 Fc receptor signaling pathway 1 Q8IZP0,Q8WUW1 33 6.27e-03 3582 4 4 1.000 0.001 TF:M01587_0 tf 1 Factor: FPM315; motif: SRGGGAGGAGGN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 6.39e-03 176 4 2 0.500 0.011 GO:0031252 CC 1 cell leading edge 1 Q8IZP0,Q8WUW1 33 6.90e-03 22 4 1 0.250 0.045 TF:M06010_0 tf 1 Factor: ZNF701; motif: NTGGGCANAAGA; match class: 0 1 Q8WUW1 33 8.00e-03 477 4 2 0.500 0.004 TF:M05304_0 tf 1 Factor: Zbtb5; motif: AGGRAGCTTC; match class: 0 1 Q8IZP0,Q6T4R5 33 8.13e-03 481 4 2 0.500 0.004 TF:M02053_1 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 1 Q70E73,Q6T4R5 33 8.13e-03 5 4 1 0.250 0.200 GO:2000601 BP 1 positive regulation of Arp2/3 complex-mediated actin nucleation 1 Q8WUW1 33 8.80e-03 501 4 2 0.500 0.004 TF:M02075_1 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 1 1 Q70E73,Q8WUW1 33 9.24e-03 212 4 2 0.500 0.009 GO:0007015 BP 1 actin filament organization 1 Q8IZP0,Q8WUW1 33 9.59e-03 216 4 2 0.500 0.009 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 Q8IZP0,Q8WUW1 33 9.71e-03 31 4 1 0.250 0.032 TF:M06910_0 tf 1 Factor: ZNF224; motif: ARAGTSAGTCC; match class: 0 1 Q70E73 33 1.10e-02 1856 4 3 0.750 0.002 TF:M02021_0 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 0 1 Q8IZP0,Q70E73,Q8WUW1 33 1.13e-02 235 4 2 0.500 0.009 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 Q8IZP0,Q8WUW1 33 1.17e-02 4190 4 4 1.000 0.001 TF:M00747_1 tf 1 Factor: IRF-1; motif: TTCACTT; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 1.25e-02 40 4 1 0.250 0.025 TF:M00615_1 tf 1 Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1 1 Q6T4R5 33 1.25e-02 40 4 1 0.250 0.025 TF:M00615_0 tf 1 Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 0 1 Q6T4R5 33 1.36e-02 1994 4 3 0.750 0.002 TF:M00980_1 tf 1 Factor: TBP; motif: TTTATAN; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5 33 1.46e-02 9 4 1 0.250 0.111 GO:0010592 BP 1 positive regulation of lamellipodium assembly 1 Q8WUW1 33 1.47e-02 47 4 1 0.250 0.021 TF:M07207_1 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 1 1 Q6T4R5 33 1.63e-02 10 4 1 0.250 0.100 GO:0034315 BP 1 regulation of Arp2/3 complex-mediated actin nucleation 1 Q8WUW1 33 1.71e-02 705 4 2 0.500 0.003 TF:M07052_1 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 1 Q8IZP0,Q8WUW1 33 1.72e-02 55 4 1 0.250 0.018 TF:M06393_0 tf 1 Factor: ZNF765; motif: NTGGYAAGGRSA; match class: 0 1 Q8IZP0 33 1.75e-02 4627 4 4 1.000 0.001 TF:M03579_1 tf 1 Factor: PEA3; motif: AGGAAGT; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 1.75e-02 4627 4 4 1.000 0.001 TF:M07382_1 tf 1 Factor: Fli-1; motif: MGGAAGT; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 1.75e-02 4627 4 4 1.000 0.001 TF:M01870_1 tf 1 Factor: C-ets-1; motif: AGGAAGN; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 1.75e-02 4627 4 4 1.000 0.001 TF:M02278_1 tf 1 Factor: SPI1; motif: AGGAAGT; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 1.75e-02 56 4 1 0.250 0.018 TF:M06018_0 tf 1 Factor: ZNF233; motif: NRWTAAAARACA; match class: 0 1 Q6T4R5 33 1.79e-02 11 4 1 0.250 0.091 GO:0051127 BP 1 positive regulation of actin nucleation 1 Q8WUW1 33 1.79e-02 11 4 1 0.250 0.091 GO:0070207 BP 1 protein homotrimerization 1 Q8WUW1 33 1.87e-02 303 4 2 0.500 0.007 GO:0002757 BP 1 immune response-activating signal transduction 1 Q8IZP0,Q8WUW1 33 1.93e-02 62 4 1 0.250 0.016 TF:M05714_0 tf 1 Factor: Evi-1; motif: KGGTCMMAACTN; match class: 0 1 Q8IZP0 33 2.02e-02 653 4 2 0.500 0.003 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 Q70E73,Q6T4R5 33 2.02e-02 4802 4 4 1.000 0.001 TF:M07437_0 tf 1 Factor: ZBTB2; motif: TCCKCCTSR; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.04e-02 317 4 2 0.500 0.006 GO:0002252 BP 1 immune effector process 1 Q8IZP0,Q8WUW1 33 2.11e-02 322 4 2 0.500 0.006 GO:0002764 BP 1 immune response-regulating signaling pathway 1 Q8IZP0,Q8WUW1 33 2.19e-02 4895 4 4 1.000 0.001 TF:M07435_0 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.24e-02 72 4 1 0.250 0.014 TF:M04183_0 tf 1 Factor: NEUROG2; motif: RACATATGTC; match class: 0 1 Q8IZP0 33 2.27e-02 73 4 1 0.250 0.014 TF:M05974_0 tf 1 Factor: ZNF701; motif: KGGGAATGCAGM; match class: 0 1 Q6T4R5 33 2.30e-02 337 4 2 0.500 0.006 GO:0002253 BP 1 activation of immune response 1 Q8IZP0,Q8WUW1 33 2.37e-02 76 4 1 0.250 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q70E73 33 2.38e-02 231 4 2 0.500 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 Q8IZP0,Q8WUW1 33 2.40e-02 77 4 1 0.250 0.013 TF:M05715_0 tf 1 Factor: ZNF133; motif: KGGTAAAAAAAA; match class: 0 1 Q8WUW1 33 2.47e-02 2461 4 3 0.750 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q70E73,Q6T4R5,Q8WUW1 33 2.54e-02 354 4 2 0.500 0.006 GO:0006897 BP 1 endocytosis 1 Q8IZP0,Q8WUW1 33 2.59e-02 358 4 2 0.500 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 Q8IZP0,Q8WUW1 33 2.60e-02 5113 4 4 1.000 0.001 TF:M04344_0 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.64e-02 2519 4 3 0.750 0.001 TF:M00744_1 tf 1 Factor: POU1F1; motif: ATGAATAAWT; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5 33 2.73e-02 5173 4 4 1.000 0.001 TF:M04299_0 tf 1 Factor: DLX1; motif: NNTAATTANN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.74e-02 903 4 2 0.500 0.002 TF:M04415_1 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 1 1 Q8IZP0,Q70E73 33 2.76e-02 17 4 1 0.250 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 Q8WUW1 33 2.76e-02 17 4 1 0.250 0.059 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 Q8WUW1 33 2.79e-02 5202 4 4 1.000 0.001 TF:M04514_1 tf 1 Factor: CPEB1; motif: AATAAAAA; match class: 1 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 2.83e-02 91 4 1 0.250 0.011 TF:M06051_0 tf 1 Factor: ZNF208; motif: NGGGGGGGTGGA; match class: 0 1 Q70E73 33 2.83e-02 91 4 1 0.250 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 Q6T4R5 33 2.86e-02 92 4 1 0.250 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 Q8WUW1 33 2.87e-02 925 4 2 0.500 0.002 TF:M01587_1 tf 1 Factor: FPM315; motif: SRGGGAGGAGGN; match class: 1 1 Q8IZP0,Q6T4R5 33 2.95e-02 95 4 1 0.250 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 Q8IZP0 33 2.98e-02 384 4 2 0.500 0.005 GO:0032403 MF 1 protein complex binding 1 Q8IZP0,Q8WUW1 33 3.02e-02 387 4 2 0.500 0.005 GO:0050778 BP 1 positive regulation of immune response 1 Q8IZP0,Q8WUW1 33 3.03e-02 2647 4 3 0.750 0.001 TF:M04343_0 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5 33 3.08e-02 19 4 1 0.250 0.053 GO:0051125 BP 1 regulation of actin nucleation 1 Q8WUW1 33 3.08e-02 19 4 1 0.250 0.053 GO:0070206 BP 1 protein trimerization 1 Q8WUW1 33 3.08e-02 19 4 1 0.250 0.053 GO:0016601 BP 1 Rac protein signal transduction 1 Q8WUW1 33 3.17e-02 102 4 1 0.250 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 Q8WUW1 33 3.20e-02 103 4 1 0.250 0.010 TF:M00264_1 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 1 1 Q8IZP0 33 3.23e-02 985 4 2 0.500 0.002 TF:M02102_1 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 1 Q8IZP0,Q8WUW1 33 3.28e-02 272 4 2 0.500 0.007 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q8IZP0,Q8WUW1 33 3.33e-02 5439 4 4 1.000 0.001 TF:M04312_0 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 3.36e-02 1006 4 2 0.500 0.002 TF:M07141_1 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 1 1 Q8IZP0,Q6T4R5 33 3.41e-02 21 4 1 0.250 0.048 GO:0034314 BP 1 Arp2/3 complex-mediated actin nucleation 1 Q8WUW1 33 3.41e-02 5471 4 4 1.000 0.001 TF:M00252_0 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 3.42e-02 278 4 2 0.500 0.007 REAC:194138 rea 1 Signaling by VEGF 1 Q8IZP0,Q8WUW1 33 3.53e-02 419 4 2 0.500 0.005 GO:0030029 BP 1 actin filament-based process 1 Q8IZP0,Q8WUW1 33 3.67e-02 1054 4 2 0.500 0.002 TF:M00769_0 tf 1 Factor: AML; motif: NNGKNTGTGGTTWNC; match class: 0 1 Q70E73,Q6T4R5 33 3.68e-02 1055 4 2 0.500 0.002 TF:M00201_1 tf 1 Factor: C/EBP; motif: NGWVTKNKGYAAKNSAYA; match class: 1 1 Q70E73,Q6T4R5 33 3.72e-02 1061 4 2 0.500 0.002 TF:M07297_1 tf 1 Factor: MAZ; motif: CCCTCCCYCYN; match class: 1 1 Q70E73,Q8WUW1 33 3.72e-02 120 4 1 0.250 0.008 TF:M04108_1 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 1 1 Q70E73 33 3.75e-02 432 4 2 0.500 0.005 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q8IZP0,Q8WUW1 33 3.90e-02 126 4 1 0.250 0.008 TF:M03835_1 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 1 1 Q8WUW1 33 3.92e-02 5666 4 4 1.000 0.001 TF:M04321_0 tf 1 Factor: EVX2; motif: NNTNATTANN; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 4.04e-02 1109 4 2 0.500 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 Q8IZP0,Q70E73 33 4.06e-02 25 4 1 0.250 0.040 GO:0048365 MF 1 Rac GTPase binding 1 Q8WUW1 33 4.12e-02 133 4 1 0.250 0.008 TF:M06033_0 tf 1 Factor: ZNF878; motif: NGGTTTTANTCM; match class: 0 1 Q6T4R5 33 4.12e-02 2953 4 3 0.750 0.001 TF:M00231_0 tf 1 Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 0 1 Q8IZP0,Q70E73,Q8WUW1 33 4.18e-02 135 4 1 0.250 0.007 TF:M03904_0 tf 1 Factor: GLIS2; motif: GACCCCCCGCRANG; match class: 0 1 Q70E73 33 4.18e-02 135 4 1 0.250 0.007 TF:M01224_1 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 1 Q70E73 33 4.32e-02 3003 4 3 0.750 0.001 TF:M00432_1 tf 1 Factor: TTF1; motif: ASTCAAGTRK; match class: 1 1 Q8IZP0,Q70E73,Q8WUW1 33 4.38e-02 27 4 1 0.250 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q8WUW1 33 4.49e-02 2582 4 3 0.750 0.001 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 Q8IZP0,Q70E73,Q6T4R5 33 4.59e-02 1187 4 2 0.500 0.002 TF:M00410_1 tf 1 Factor: SOX9; motif: NNNNAACAATRGNN; match class: 1 1 Q70E73,Q6T4R5 33 4.68e-02 1200 4 2 0.500 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q8IZP0,Q6T4R5 33 4.73e-02 3103 4 3 0.750 0.001 TF:M02075_0 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 0 1 Q8IZP0,Q70E73,Q8WUW1 33 4.81e-02 156 4 1 0.250 0.006 TF:M04515_0 tf 1 Factor: E2F1; motif: WWTGGCGCCAAA; match class: 0 1 Q6T4R5 33 4.82e-02 1219 4 2 0.500 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q8IZP0,Q8WUW1 33 4.86e-02 30 4 1 0.250 0.033 GO:0045010 BP 1 actin nucleation 1 Q8WUW1 33 4.87e-02 158 4 1 0.250 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 Q8IZP0 33 4.88e-02 5983 4 4 1.000 0.001 TF:M00216_0 tf 1 Factor: TATA; motif: NCTATAAAAR; match class: 0 1 Q8IZP0,Q70E73,Q6T4R5,Q8WUW1 33 4.93e-02 160 4 1 0.250 0.006 TF:M06001_0 tf 1 Factor: ZNF316; motif: RTTGAAAAGM; match class: 0 1 Q8WUW1 33 4.96e-02 499 4 2 0.500 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 Q8IZP0,Q8WUW1 33 5.00e-02 2 4 1 0.250 0.500 CORUM:2297 cor 1 ABI1-WASL complex 1 Q8IZP0 33 5.00e-02 2 4 1 0.250 0.500 CORUM:2294 cor 1 ABI1-WASF2 complex 1 Q8IZP0 33 5.00e-02 1 4 1 0.250 1.000 HP:0006346 hp 1 Screwdriver-shaped incisors 1 Q6T4R5 33 5.00e-02 1 4 1 0.250 1.000 HP:0006332 hp 1 Supernumerary maxillary incisor 1 Q6T4R5 33 5.00e-02 501 4 2 0.500 0.004 GO:0050776 BP 1 regulation of immune response 1 Q8IZP0,Q8WUW1 33 5.00e-02 1 4 1 0.250 1.000 OMIM:302200 omi 1 CATARACT 40; CTRCT40;;CATARACT 40 WITH OR WITHOUT MICROCORNEA;;CATARACT, CONGENITAL, X-LINKED; CXN;;CATARACT, CONGENITAL TOTAL, WITH POSTERIOR SUTURAL OPACITIES IN HETEROZYGOTES;CCT 1 Q6T4R5 33 5.00e-02 1 4 1 0.250 1.000 OMIM:302350 omi 1 NANCE-HORAN SYNDROME; NHS;;CATARACT-DENTAL SYNDROME;;CATARACT, X-LINKED, WITH HUTCHINSONIAN TEETH;;MESIODENS-CATARACT SYNDROME 1 Q6T4R5 33 5.00e-02 338 4 2 0.500 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q8IZP0,Q8WUW1 34 1.92e-03 491 2 2 1.000 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 P49759,Q13595 34 1.99e-03 500 2 2 1.000 0.004 MI:hsa-miR-524-5p mi 1 MI:hsa-miR-524-5p 1 P49759,Q13595 34 5.00e-02 287 2 2 1.000 0.007 TF:M04416_1 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 1 1 P49759,Q13595 34 5.00e-02 42 2 1 0.500 0.024 KEGG:05134 keg 1 Legionellosis 1 P49759 34 5.00e-02 287 2 2 1.000 0.007 TF:M04381_1 tf 1 Factor: ISX; motif: NYAATTAN; match class: 1 1 P49759,Q13595 34 5.00e-02 326 2 2 1.000 0.006 GO:0008380 BP 1 RNA splicing 1 P49759,Q13595 35 1.26e-03 4 4 1 0.250 0.250 TF:M06441_0 tf 1 Factor: ZSCAN30; motif: KGGTGCGGGATA; match class: 0 1 P54819 35 1.88e-03 1 4 1 0.250 1.000 OMIM:267500 omi 1 RETICULAR DYSGENESIS;;RETICULAR DYSGENESIA;;CONGENITAL ALEUKIA;;SEVERE COMBINED IMMUNODEFICIENCY WITH LEUKOPENIA;;DE VAAL DISEASE;;HEMATOPOIETIC HYPOPLASIA, GENERALIZED;;ALEUKOCYTOSIS 1 P54819 35 1.88e-03 1 4 1 0.250 1.000 OMIM:610505 omi 1 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 3; COXPD3;;ENCEPHALOMYOPATHY, RESPIRATORY FAILURE, AND LACTIC ACIDOSIS;;CONCENTRIC CARDIOMYOPATHY, HYPOTONIA, AND LACTIC ACIDOSIS 1 P43897 35 3.77e-03 12 4 1 0.250 0.083 TF:M03865_1 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 1 1 P43897 35 4.39e-03 14 4 1 0.250 0.071 TF:M00956_1 tf 1 Factor: AR; motif: NNNNNNRGNACRNNGTGTTCTNNNNNN; match class: 1 1 P43897 35 6.86e-03 388 4 2 0.500 0.005 MI:mmu-miR-698 mi 1 MI:mmu-miR-698 1 P54819,P43897 35 6.90e-03 22 4 1 0.250 0.045 TF:M06723_0 tf 1 Factor: ZNF492; motif: KGGTRAGGAAGA; match class: 0 1 P54819 35 8.04e-03 421 4 2 0.500 0.005 MI:hsa-miR-607 mi 1 MI:hsa-miR-607 1 P43897,P07205 35 1.31e-02 42 4 1 0.250 0.024 TF:M05410_0 tf 1 Factor: ZSCAN1; motif: GGGKACAYKAGGC; match class: 0 1 Q9BRA2 35 1.38e-02 44 4 1 0.250 0.023 TF:M06021_0 tf 1 Factor: ZNF98; motif: NTGGAWAGAAGA; match class: 0 1 P07205 35 1.49e-02 2061 4 3 0.750 0.001 TF:M00777_0 tf 1 Factor: STAT; motif: NNNNNTTCTKGGA; match class: 0 1 P43897,Q9BRA2,P07205 35 1.56e-02 50 4 1 0.250 0.020 TF:M06764_0 tf 1 Factor: ZNF228; motif: NCCGCCGAACCC; match class: 0 1 Q9BRA2 35 1.62e-02 52 4 1 0.250 0.019 TF:M05427_1 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 1 1 Q9BRA2 35 1.84e-02 59 4 1 0.250 0.017 TF:M04046_0 tf 1 Factor: MYBL2; motif: AACSGTTAACSGNY; match class: 0 1 P07205 35 1.98e-02 4778 4 4 1.000 0.001 TF:M00160_1 tf 1 Factor: SRY; motif: NWWAACAAWANN; match class: 1 1 P54819,P43897,Q9BRA2,P07205 35 2.09e-02 67 4 1 0.250 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 P43897 35 2.18e-02 70 4 1 0.250 0.014 TF:M06184_0 tf 1 Factor: ZNF85; motif: NGGGATGGAAGM; match class: 0 1 P07205 35 2.37e-02 76 4 1 0.250 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 P43897 35 2.41e-02 5016 4 4 1.000 0.001 TF:M00517_0 tf 1 Factor: AP-1; motif: NNNTGAGTCAKCN; match class: 0 1 P54819,P43897,Q9BRA2,P07205 35 2.48e-02 5050 4 4 1.000 0.001 TF:M01968_0 tf 1 Factor: FOXO1; motif: TGTTKAC; match class: 0 1 P54819,P43897,Q9BRA2,P07205 35 2.50e-02 1 4 1 0.250 1.000 GO:0047134 MF 1 protein-disulfide reductase activity 1 Q9BRA2 35 2.50e-02 1 4 1 0.250 1.000 HP:0005354 hp 1 Absent cellular immunity 1 P54819 35 2.71e-02 87 4 1 0.250 0.011 TF:M06727_1 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 1 1 Q9BRA2 35 2.95e-02 2620 4 3 0.750 0.001 TF:M07309_0 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 0 1 P43897,Q9BRA2,P07205 35 2.95e-02 95 4 1 0.250 0.011 TF:M06130_0 tf 1 Factor: ZNF254; motif: KGGTWCKAAGGM; match class: 0 1 Q9BRA2 35 2.98e-02 96 4 1 0.250 0.010 TF:M00929_1 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 1 1 Q9BRA2 35 2.98e-02 96 4 1 0.250 0.010 TF:M04204_0 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 0 1 Q9BRA2 35 3.04e-02 954 4 2 0.500 0.002 TF:M02378_0 tf 1 Factor: HIF1A:ARNT; motif: VNACGTGN; match class: 0 1 P54819,Q9BRA2 35 3.11e-02 100 4 1 0.250 0.010 TF:M06541_0 tf 1 Factor: ZNF502; motif: NGKTAGGRAATC; match class: 0 1 P07205 35 3.14e-02 101 4 1 0.250 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 P43897 35 3.18e-02 2690 4 3 0.750 0.001 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 P54819,Q9BRA2,P07205 35 3.26e-02 105 4 1 0.250 0.010 TF:M06407_0 tf 1 Factor: ZNF677; motif: NKTTAAAAAACA; match class: 0 1 P07205 35 3.41e-02 110 4 1 0.250 0.009 TF:M06215_0 tf 1 Factor: ZNF33b; motif: NTGTCCAANGGA; match class: 0 1 Q9BRA2 35 3.54e-02 114 4 1 0.250 0.009 TF:M07314_1 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 1 1 P43897 35 3.54e-02 114 4 1 0.250 0.009 TF:M04218_1 tf 1 Factor: MAFK; motif: NTGCTGANTCAGCRN; match class: 1 1 P54819 35 3.57e-02 115 4 1 0.250 0.009 TF:M07103_0 tf 1 Factor: JunB; motif: NRRTGASTCAK; match class: 0 1 P07205 35 3.61e-02 2816 4 3 0.750 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 P54819,Q9BRA2,P07205 35 3.81e-02 1075 4 2 0.500 0.002 TF:M04291_0 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 0 1 P54819,P07205 35 3.84e-02 124 4 1 0.250 0.008 TF:M05358_0 tf 1 Factor: RLF; motif: GCATCRWCATT; match class: 0 1 P43897 35 3.91e-02 25 4 1 0.250 0.040 REAC:499943 rea 1 Synthesis and interconversion of nucleotide di- and triphosphates 1 P54819 35 4.04e-02 1109 4 2 0.500 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 P43897,P07205 35 4.16e-02 1127 4 2 0.500 0.002 TF:M01045_0 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 0 1 P54819,Q9BRA2 35 4.26e-02 1140 4 2 0.500 0.002 TF:M00472_1 tf 1 Factor: FOXO4; motif: RWAAACAANNN; match class: 1 1 P54819,P07205 35 4.27e-02 1142 4 2 0.500 0.002 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 P54819,P43897 35 4.27e-02 2990 4 3 0.750 0.001 TF:M00042_1 tf 1 Factor: SOX5; motif: NNAACAATNN; match class: 1 1 P54819,P43897,P07205 35 4.30e-02 139 4 1 0.250 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 P54819 35 4.42e-02 143 4 1 0.250 0.007 TF:M04202_0 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 0 1 Q9BRA2 35 4.56e-02 3061 4 3 0.750 0.001 TF:M00222_0 tf 1 Factor: Hand1:E47; motif: NNNNGNRTCTGGMWTT; match class: 0 1 P54819,P43897,P07205 35 4.59e-02 1187 4 2 0.500 0.002 TF:M00410_1 tf 1 Factor: SOX9; motif: NNNNAACAATRGNN; match class: 1 1 P54819,Q9BRA2 35 4.74e-02 5939 4 4 1.000 0.001 TF:M04077_0 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 0 1 P54819,P43897,Q9BRA2,P07205 35 4.90e-02 1229 4 2 0.500 0.002 TF:M01116_0 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 0 1 P54819,Q9BRA2 35 5.00e-02 2 4 1 0.250 0.500 HP:0005157 hp 1 Concentric hypertrophic cardiomyopathy 1 P43897 35 5.00e-02 2 4 1 0.250 0.500 HP:0005541 hp 1 Congenital agranulocytosis 1 P54819 35 5.00e-02 2 4 1 0.250 0.500 GO:0004618 MF 1 phosphoglycerate kinase activity 1 P07205 35 5.00e-02 2 4 1 0.250 0.500 HP:0012234 hp 1 Agranulocytosis 1 P54819 35 5.00e-02 32 4 1 0.250 0.031 REAC:70171 rea 1 Glycolysis 1 P07205 35 5.00e-02 14 4 1 0.250 0.071 KEGG:00730 keg 1 Thiamine metabolism 1 P54819 35 5.00e-02 3 4 1 0.250 0.333 CORUM:5856 cor 1 AK2-FADD-caspase-10 (AFAC10) complex 1 P54819 35 5.00e-02 32 4 1 0.250 0.031 REAC:70263 rea 1 Gluconeogenesis 1 P07205 35 5.00e-02 2 4 1 0.250 0.500 HP:0008347 hp 1 Decreased activity of mitochondrial complex IV 1 P43897 36 4.53e-04 37 3 2 0.667 0.054 GO:0007565 BP 1 female pregnancy 1 Q9UQ72,Q00888 36 5.57e-04 41 3 2 0.667 0.049 GO:0044706 BP 1 multi-multicellular organism process 1 Q9UQ72,Q00888 36 2.11e-03 264 3 3 1.000 0.011 TF:M01217_1 tf 1 Factor: NUR77; motif: NTGACCTTBN; match class: 1 1 Q99999,Q9UQ72,Q00888 36 3.28e-03 375 3 2 0.667 0.005 MI:hsa-miR-431 mi 1 MI:hsa-miR-431 1 Q99999,Q00888 36 3.67e-03 397 3 2 0.667 0.005 MI:mmu-miR-684 mi 1 MI:mmu-miR-684 1 Q99999,Q00888 36 1.51e-02 508 3 3 1.000 0.006 TF:M03568_1 tf 1 Factor: TR4; motif: STGACCTTT; match class: 1 1 Q99999,Q9UQ72,Q00888 36 1.73e-02 63 3 2 0.667 0.032 TF:M06224_0 tf 1 Factor: ZNF415; motif: NGGGTGAAAMGA; match class: 0 1 Q9UQ72,Q00888 36 1.93e-02 240 3 2 0.667 0.008 GO:0044703 BP 1 multi-organism reproductive process 1 Q9UQ72,Q00888 36 5.00e-02 107 3 2 0.667 0.019 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 Q9UQ72,Q00888 36 5.00e-02 388 3 2 0.667 0.005 GO:0022414 BP 1 reproductive process 1 Q9UQ72,Q00888 36 5.00e-02 29 3 1 0.333 0.034 KEGG:00565 keg 1 Ether lipid metabolism 1 Q99999 37 2.84e-03 249 3 2 0.667 0.008 TF:M07105_0 tf 1 Factor: JunD; motif: NNNRATGAYGTCATN; match class: 0 1 Q5T5S1,P49715 37 4.12e-03 1502 3 3 1.000 0.002 TF:M00763_0 tf 1 Factor: PPAR; motif: TGACCTTTGNCCY; match class: 0 1 Q15276,Q5T5S1,P49715 37 7.82e-03 1859 3 3 1.000 0.002 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 Q15276,Q5T5S1,P49715 37 8.16e-03 1886 3 3 1.000 0.002 TF:M00217_1 tf 1 Factor: USF; motif: NCACGTGN; match class: 1 1 Q15276,Q5T5S1,P49715 37 9.46e-03 16 3 1 0.333 0.062 TF:M06012_0 tf 1 Factor: ZNF586; motif: ATGGCGTGMTG; match class: 0 1 Q5T5S1 37 1.48e-02 25 3 1 0.333 0.040 TF:M01666_1 tf 1 Factor: STAT4; motif: TTCMNAGAADHNMA; match class: 1 1 Q15276 37 1.67e-02 1 3 1 0.333 1.000 CORUM:746 cor 1 C/EBPalpha-HNF6 complex 1 P49715 37 1.71e-02 29 3 1 0.333 0.034 TF:M03917_0 tf 1 Factor: SCRT1; motif: RNGCAACAGGTGGNN; match class: 0 1 Q5T5S1 37 1.94e-02 657 3 2 0.667 0.003 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 Q15276,Q5T5S1 37 1.95e-02 33 3 1 0.333 0.030 TF:M07307_1 tf 1 Factor: Sox18; motif: ACAAWGBSNNN; match class: 1 1 Q5T5S1 37 2.24e-02 38 3 1 0.333 0.026 TF:M06666_0 tf 1 Factor: ZNF442; motif: KGKTTGTGSCGA; match class: 0 1 Q5T5S1 37 2.99e-02 10 3 1 0.333 0.100 GO:0045945 BP 1 positive regulation of transcription from RNA polymerase III promoter 1 P49715 37 3.01e-02 51 3 1 0.333 0.020 TF:M06391_0 tf 1 Factor: ZNF836; motif: NGGGGYTCCAGM; match class: 0 1 P49715 37 3.05e-02 52 3 1 0.333 0.019 KEGG:05221 keg 1 Acute myeloid leukemia 1 P49715 37 3.36e-02 57 3 1 0.333 0.018 TF:M05335_0 tf 1 Factor: egr-3; motif: GGGCGKGGGCGG; match class: 0 1 P49715 37 3.48e-02 59 3 1 0.333 0.017 TF:M01728_1 tf 1 Factor: EAR2; motif: YGNNCTTTGNCCTK; match class: 1 1 P49715 37 3.48e-02 59 3 1 0.333 0.017 TF:M04631_1 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 1 1 P49715 37 3.53e-02 3073 3 3 1.000 0.001 TF:M00121_0 tf 1 Factor: USF; motif: NNRYCACGTGRYNN; match class: 0 1 Q15276,Q5T5S1,P49715 37 3.53e-02 3073 3 3 1.000 0.001 TF:M00121_1 tf 1 Factor: USF; motif: NNRYCACGTGRYNN; match class: 1 1 Q15276,Q5T5S1,P49715 37 3.59e-02 12 3 1 0.333 0.083 GO:0030851 BP 1 granulocyte differentiation 1 P49715 37 3.59e-02 12 3 1 0.333 0.083 GO:0036158 BP 1 outer dynein arm assembly 1 Q5T5S1 37 3.60e-02 3091 3 3 1.000 0.001 TF:M00796_0 tf 1 Factor: USF; motif: NRCCACGTGASN; match class: 0 1 Q15276,Q5T5S1,P49715 37 3.61e-02 903 3 2 0.667 0.002 TF:M00977_0 tf 1 Factor: EBF; motif: KTCCCYWGRGA; match class: 0 1 Q15276,Q5T5S1 37 3.71e-02 63 3 1 0.333 0.016 TF:M06611_0 tf 1 Factor: ZNF560; motif: NNGTGGGKCAGC; match class: 0 1 P49715 37 3.71e-02 916 3 2 0.667 0.002 TF:M03889_1 tf 1 Factor: TBX2; motif: AGGTGTGARM; match class: 1 1 Q15276,Q5T5S1 37 4.09e-02 3226 3 3 1.000 0.001 TF:M00765_0 tf 1 Factor: COUP; motif: TGACCTTTGACCC; match class: 0 1 Q15276,Q5T5S1,P49715 37 4.19e-02 14 3 1 0.333 0.071 GO:0045736 BP 1 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1 P49715 37 4.19e-02 14 3 1 0.333 0.071 GO:1904030 BP 1 negative regulation of cyclin-dependent protein kinase activity 1 P49715 37 4.67e-02 1031 3 2 0.667 0.002 TF:M03998_1 tf 1 Factor: GATA4; motif: WGATAANN; match class: 1 1 Q5T5S1,P49715 37 4.84e-02 1050 3 2 0.667 0.002 TF:M02004_1 tf 1 Factor: GATA-1; motif: NNNNNWGATARNNNN; match class: 1 1 Q5T5S1,P49715 37 5.00e-02 17 3 1 0.333 0.059 OMIM:601626 omi 1 LEUKEMIA, ACUTE MYELOID; AML;;LEUKEMIA, ACUTE MYELOGENOUSLEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO, INCLUDED 1 P49715 37 5.00e-02 85 3 1 0.333 0.012 TF:M00236_0 tf 1 Factor: Arnt; motif: NDDNNCACGTGNNNNN; match class: 0 1 Q5T5S1 37 5.00e-02 29 3 1 0.333 0.034 HP:0004808 hp 1 Acute myeloid leukemia 1 P49715 37 5.00e-02 68 3 1 0.333 0.015 REAC:381340 rea 1 Transcriptional regulation of white adipocyte differentiation 1 P49715 37 5.00e-02 445 3 2 0.667 0.004 GO:0042803 MF 1 protein homodimerization activity 1 Q15276,P49715 37 5.00e-02 3 3 1 0.333 0.333 CORUM:1090 cor 1 APLG1-Rababtin5 complex 1 Q15276 38 2.48e-10 244 13 8 0.615 0.033 GO:0005635 CC 1 nuclear envelope 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9HC62,O14524,P18754 38 1.64e-09 10 13 4 0.308 0.400 REAC:3215018 rea 1 Processing and activation of SUMO 1 P63279,P63165,Q9HC62,P61956 38 1.02e-08 44 13 5 0.385 0.114 REAC:4615885 rea 1 SUMOylation of DNA replication proteins 1 Q9BTX1,Q9NRG9,P63279,P63165,P61956 38 1.07e-08 120 13 6 0.462 0.050 GO:0016925 BP 1 protein sumoylation 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 1.15e-08 45 13 5 0.385 0.111 REAC:4570464 rea 1 SUMOylation of RNA binding proteins 1 Q9BTX1,Q9NRG9,P63279,P63165,P61956 38 1.60e-08 105 13 6 0.462 0.057 REAC:2990846 rea 1 SUMOylation 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 2.58e-08 61 13 5 0.385 0.082 GO:0005643 CC 1 nuclear pore 1 Q9BTX1,Q9NRG9,P63165,Q53GS7,Q9HC62 38 1.13e-07 6 13 3 0.231 0.500 REAC:3065679 rea 1 SUMO is proteolytically processed 1 P63165,Q9HC62,P61956 38 1.58e-07 75 13 5 0.385 0.067 REAC:3108214 rea 1 SUMOylation of DNA damage response and repair proteins 1 Q9BTX1,Q9NRG9,P63279,P63165,P61956 38 1.97e-07 7 13 3 0.231 0.429 REAC:3065678 rea 1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 P63279,P63165,P61956 38 6.40e-07 99 13 5 0.385 0.051 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 Q9BTX1,Q9NRG9,P63279,P63165,P61956 38 6.88e-07 665 13 8 0.615 0.012 GO:0031967 CC 1 organelle envelope 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9HC62,O14524,P18754 38 7.13e-07 668 13 8 0.615 0.012 GO:0031975 CC 1 envelope 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9HC62,O14524,P18754 38 1.51e-06 52 13 4 0.308 0.077 GO:0016605 CC 1 PML body 1 P63279,P63165,Q9HC62,P61956 38 2.37e-06 296 13 6 0.462 0.020 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 3.79e-06 17 13 3 0.231 0.176 REAC:3232118 rea 1 SUMOylation of transcription factors 1 P63279,P63165,P61956 38 5.86e-06 179 13 5 0.385 0.028 GO:0016604 CC 1 nuclear body 1 P63279,P63165,Q9UBU9,Q9HC62,P61956 38 2.12e-05 100 13 4 0.308 0.040 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.12e-05 100 13 4 0.308 0.040 GO:0006406 BP 1 mRNA export from nucleus 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.23e-05 4 13 2 0.154 0.500 REAC:4551638 rea 1 SUMOylation of chromatin organization proteins 1 P63279,P61956 38 2.48e-05 104 13 4 0.308 0.038 GO:0051028 BP 1 mRNA transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.72e-05 32 13 3 0.231 0.094 REAC:180746 rea 1 Nuclear import of Rev protein 1 Q9BTX1,Q9NRG9,P18754 38 2.72e-05 32 13 3 0.231 0.094 REAC:159227 rea 1 Transport of the SLBP independent Mature mRNA 1 Q9BTX1,Q9NRG9,Q9UBU9 38 2.92e-05 31 13 3 0.231 0.097 GO:0070911 BP 1 global genome nucleotide-excision repair 1 P63279,P63165,P61956 38 2.99e-05 33 13 3 0.231 0.091 REAC:165054 rea 1 Rev-mediated nuclear export of HIV RNA 1 Q9BTX1,Q9NRG9,P18754 38 2.99e-05 33 13 3 0.231 0.091 REAC:159230 rea 1 Transport of the SLBP Dependant Mature mRNA 1 Q9BTX1,Q9NRG9,Q9UBU9 38 3.21e-05 111 13 4 0.308 0.036 GO:0006405 BP 1 RNA export from nucleus 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 3.33e-05 112 13 4 0.308 0.036 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 3.58e-05 35 13 3 0.231 0.086 REAC:177243 rea 1 Interactions of Rev with host cellular proteins 1 Q9BTX1,Q9NRG9,P18754 38 3.70e-05 115 13 4 0.308 0.035 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 3.71e-05 5 13 2 0.154 0.400 REAC:3065676 rea 1 SUMO is conjugated to E1 (UBA2:SAE1) 1 P63165,P61956 38 4.25e-05 37 13 3 0.231 0.081 REAC:159231 rea 1 Transport of Mature mRNA Derived from an Intronless Transcript 1 Q9BTX1,Q9NRG9,Q9UBU9 38 4.60e-05 38 13 3 0.231 0.079 REAC:159234 rea 1 Transport of Mature mRNAs Derived from Intronless Transcripts 1 Q9BTX1,Q9NRG9,Q9UBU9 38 5.15e-05 125 13 4 0.308 0.032 GO:0050658 BP 1 RNA transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 5.15e-05 125 13 4 0.308 0.032 GO:0050657 BP 1 nucleic acid transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 5.66e-05 128 13 4 0.308 0.031 GO:0051236 BP 1 establishment of RNA localization 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 6.24e-05 42 13 3 0.231 0.071 REAC:5696395 rea 1 Formation of Incision Complex in GG-NER 1 P63279,P63165,P61956 38 7.73e-05 2260 13 10 0.769 0.004 GO:0012505 CC 1 endomembrane system 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9HC62,O14524,P18754 38 8.54e-05 142 13 4 0.308 0.028 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 9.79e-05 147 13 4 0.308 0.027 GO:0031965 CC 1 nuclear membrane 1 Q9BTX1,Q9NRG9,P63165,P18754 38 1.04e-04 6 13 2 0.154 0.333 GO:0031386 MF 1 protein tag 1 P63165,P61956 38 1.10e-04 573 13 6 0.462 0.010 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 1.15e-04 153 13 4 0.308 0.026 GO:0051168 BP 1 nuclear export 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 1.30e-04 158 13 4 0.308 0.025 GO:0006403 BP 1 RNA localization 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.50e-04 662 13 6 0.462 0.009 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 2.65e-04 68 13 3 0.231 0.044 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 Q9BTX1,Q9NRG9,Q9UBU9 38 3.41e-04 74 13 3 0.231 0.041 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 P63279,P63165,P61956 38 3.55e-04 75 13 3 0.231 0.040 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 Q9BTX1,Q9NRG9,Q9UBU9 38 4.02e-04 720 13 6 0.462 0.008 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 4.79e-04 83 13 3 0.231 0.036 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 P63279,P63165,P61956 38 9.28e-04 104 13 3 0.231 0.029 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 P63279,P63165,P61956 38 1.04e-03 521 13 5 0.385 0.010 GO:0044451 CC 1 nucleoplasm part 1 P63279,P63165,Q9UBU9,Q9HC62,P61956 38 1.04e-03 712 13 6 0.462 0.008 REAC:597592 rea 1 Post-translational protein modification 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 1.06e-03 109 13 3 0.231 0.028 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P63279,P63165,P61956 38 1.09e-03 110 13 3 0.231 0.027 REAC:5693538 rea 1 Homology Directed Repair 1 P63279,P63165,P61956 38 1.23e-03 107 13 3 0.231 0.028 GO:0006289 BP 1 nucleotide-excision repair 1 P63279,P63165,P61956 38 1.36e-03 7661 13 13 1.000 0.002 TF:M00380_0 tf 1 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.57e-03 30 13 2 0.154 0.067 REAC:168333 rea 1 NEP/NS2 Interacts with the Cellular Export Machinery 1 Q9BTX1,Q9NRG9 38 1.57e-03 30 13 2 0.154 0.067 REAC:170822 rea 1 Regulation of Glucokinase by Glucokinase Regulatory Protein 1 Q9BTX1,Q9NRG9 38 1.57e-03 30 13 2 0.154 0.067 REAC:168274 rea 1 Export of Viral Ribonucleoproteins from Nucleus 1 Q9BTX1,Q9NRG9 38 1.57e-03 30 13 2 0.154 0.067 REAC:168271 rea 1 Transport of Ribonucleoproteins into the Host Nucleus 1 Q9BTX1,Q9NRG9 38 1.58e-03 125 13 3 0.231 0.024 REAC:162909 rea 1 Host Interactions of HIV factors 1 Q9BTX1,Q9NRG9,P18754 38 1.73e-03 129 13 3 0.231 0.023 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 Q9BTX1,Q9NRG9,P18754 38 1.74e-03 3168 13 10 0.769 0.003 GO:0044428 CC 1 nuclear part 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.79e-03 32 13 2 0.154 0.062 REAC:180910 rea 1 Vpr-mediated nuclear import of PICs 1 Q9BTX1,Q9NRG9 38 1.97e-03 318 13 4 0.308 0.013 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.02e-03 34 13 2 0.154 0.059 REAC:3301854 rea 1 Nuclear Pore Complex (NPC) Disassembly 1 Q9BTX1,Q9NRG9 38 2.06e-03 137 13 3 0.231 0.022 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 P63279,P63165,P61956 38 2.11e-03 324 13 4 0.308 0.012 GO:0051169 BP 1 nuclear transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 2.14e-03 35 13 2 0.154 0.057 REAC:176033 rea 1 Interactions of Vpr with host cellular proteins 1 Q9BTX1,Q9NRG9 38 2.20e-03 140 13 3 0.231 0.021 REAC:162587 rea 1 HIV Life Cycle 1 Q9BTX1,Q9NRG9,P18754 38 2.58e-03 148 13 3 0.231 0.020 REAC:913531 rea 1 Interferon Signaling 1 Q9BTX1,Q9NRG9,P63165 38 2.65e-03 39 13 2 0.154 0.051 REAC:70153 rea 1 Glucose transport 1 Q9BTX1,Q9NRG9 38 2.65e-03 39 13 2 0.154 0.051 REAC:168276 rea 1 NS1 Mediated Effects on Host Pathways 1 Q9BTX1,Q9NRG9 38 2.93e-03 41 13 2 0.154 0.049 REAC:168253 rea 1 Host Interactions with Influenza Factors 1 Q9BTX1,Q9NRG9 38 3.06e-03 3 13 1 0.077 0.333 TF:M04056_1 tf 1 Factor: NF-1A; motif: TTGGCANNNTGCCAR; match class: 1 1 Q9HC62 38 3.06e-03 3 13 1 0.077 0.333 TF:M04056_0 tf 1 Factor: NF-1A; motif: TTGGCANNNTGCCAR; match class: 0 1 Q9HC62 38 3.07e-03 42 13 2 0.154 0.048 REAC:168325 rea 1 Viral Messenger RNA Synthesis 1 Q9BTX1,Q9NRG9 38 3.17e-03 31 13 2 0.154 0.065 GO:0071431 BP 1 tRNA-containing ribonucleoprotein complex export from nucleus 1 Q9BTX1,Q9NRG9 38 3.17e-03 31 13 2 0.154 0.065 GO:0006409 BP 1 tRNA export from nucleus 1 Q9BTX1,Q9NRG9 38 3.22e-03 43 13 2 0.154 0.047 REAC:189200 rea 1 Hexose transport 1 Q9BTX1,Q9NRG9 38 3.59e-03 33 13 2 0.154 0.061 GO:0051031 BP 1 tRNA transport 1 Q9BTX1,Q9NRG9 38 3.59e-03 877 13 7 0.538 0.008 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 P63279,P63165,Q53GS7,Q9UBU9,Q9HC62,P18754,P61956 38 3.64e-03 374 13 4 0.308 0.011 GO:0071705 BP 1 nitrogen compound transport 1 Q9BTX1,Q9NRG9,Q53GS7,Q9UBU9 38 4.34e-03 50 13 2 0.154 0.040 REAC:194441 rea 1 Metabolism of non-coding RNA 1 Q9BTX1,Q9NRG9 38 4.34e-03 50 13 2 0.154 0.040 REAC:2980766 rea 1 Nuclear Envelope Breakdown 1 Q9BTX1,Q9NRG9 38 4.34e-03 50 13 2 0.154 0.040 REAC:191859 rea 1 snRNP Assembly 1 Q9BTX1,Q9NRG9 38 4.86e-03 53 13 2 0.154 0.038 REAC:5693565 rea 1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 P63279,P63165 38 5.05e-03 54 13 2 0.154 0.037 REAC:5693606 rea 1 DNA Double Strand Break Response 1 P63279,P63165 38 5.10e-03 5 13 1 0.077 0.200 TF:M04058_1 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 1 1 Q9HC62 38 5.23e-03 55 13 2 0.154 0.036 REAC:6784531 rea 1 tRNA processing in the nucleus 1 Q9BTX1,Q9NRG9 38 5.65e-03 3184 13 8 0.615 0.003 TF:M01798_0 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 0 1 Q9BTX1,P63165,Q53GS7,Q6NUQ4,Q96SK2,Q9UBU9,O14524,P18754 38 5.72e-03 113 13 2 0.154 0.018 TF:M00284_1 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 1 1 Q9UBU9,P18754 38 5.82e-03 42 13 2 0.154 0.048 GO:0007077 BP 1 mitotic nuclear envelope disassembly 1 Q9BTX1,Q9NRG9 38 5.83e-03 7114 13 12 0.923 0.002 TF:M07056_1 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 1 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9HC62,O14524,P18754,P61956 38 5.83e-03 7114 13 12 0.923 0.002 TF:M02114_1 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 1 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9HC62,O14524,P18754,P61956 38 6.00e-03 59 13 2 0.154 0.034 REAC:5578749 rea 1 Transcriptional regulation by small RNAs 1 Q9BTX1,Q9NRG9 38 6.26e-03 8617 13 13 1.000 0.002 TF:M01104_0 tf 1 Factor: MOVO-B; motif: GNGGGGG; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 6.32e-03 119 13 2 0.154 0.017 TF:M04470_1 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 1 1 P63165,O14524 38 6.39e-03 44 13 2 0.154 0.045 GO:0051081 BP 1 nuclear envelope disassembly 1 Q9BTX1,Q9NRG9 38 6.39e-03 44 13 2 0.154 0.045 GO:0030397 BP 1 membrane disassembly 1 Q9BTX1,Q9NRG9 38 6.66e-03 1 13 1 0.077 1.000 GO:1903755 BP 1 positive regulation of SUMO transferase activity 1 P63279 38 6.66e-03 1 13 1 0.077 1.000 GO:1903182 BP 1 regulation of SUMO transferase activity 1 P63279 38 6.66e-03 1 13 1 0.077 1.000 GO:0061656 MF 1 SUMO conjugating enzyme activity 1 P63279 38 6.66e-03 1 13 1 0.077 1.000 GO:0070762 CC 1 nuclear pore transmembrane ring 1 Q9BTX1 38 6.66e-03 1 13 1 0.077 1.000 GO:1990356 CC 1 sumoylated E2 ligase complex 1 P63279 38 6.66e-03 1 13 1 0.077 1.000 GO:0050290 MF 1 sphingomyelin phosphodiesterase D activity 1 Q9NXE4 38 6.66e-03 1 13 1 0.077 1.000 GO:0045759 BP 1 negative regulation of action potential 1 P63165 38 7.47e-03 66 13 2 0.154 0.030 REAC:1169408 rea 1 ISG15 antiviral mechanism 1 Q9BTX1,Q9NRG9 38 7.47e-03 66 13 2 0.154 0.030 REAC:1169410 rea 1 Antiviral mechanism by IFN-stimulated genes 1 Q9BTX1,Q9NRG9 38 7.80e-03 219 13 3 0.231 0.014 REAC:162906 rea 1 HIV Infection 1 Q9BTX1,Q9NRG9,P18754 38 8.43e-03 1 13 1 0.077 1.000 OMIM:231550 omi 1 ACHALASIA-ADDISONIANISM-ALACRIMA SYNDROME; AAAS;;TRIPLE-A SYNDROME;;ALACRIMA-ACHALASIA-ADRENAL INSUFFICIENCY NEUROLOGIC DISORDER;;GLUCOCORTICOID DEFICIENCY AND ACHALASIA;;ALLGROVE SYNDROME;;ADDISONIAN-ACHALASIA SYNDROME;;HYPOADRENALISM WITH ACHALASIA;;ALACRIMA-ACHALASIA-ADDISONIANISM;;ACTH-RESISTANT ADRENAL INSUFFICIENCY, ACHALASIA AND ALACRIMAACHALASIA-ALACRIMA SYNDROME, INCLUDED 1 Q9NRG9 38 8.43e-03 1 13 1 0.077 1.000 OMIM:613705 omi 1 OROFACIAL CLEFT 10; OFC10;;CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 10 1 P63165 38 8.43e-03 1 13 1 0.077 1.000 OMIM:611890 omi 1 LETHAL ARTHROGRYPOSIS WITH ANTERIOR HORN CELL DISEASE; LAAHD 1 Q53GS7 38 8.73e-03 228 13 3 0.231 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q9BTX1,Q9NRG9,Q9UBU9 38 8.91e-03 52 13 2 0.154 0.038 GO:0032436 BP 1 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1 P63165,P61956 38 9.37e-03 392 13 3 0.231 0.008 MI:hsa-miR-652 mi 1 MI:hsa-miR-652 1 P63279,Q53GS7,Q9UBU9 38 9.58e-03 449 13 3 0.231 0.007 TF:M03866_1 tf 1 Factor: c-Fos:c-Jun; motif: NTGACTCAN; match class: 1 1 Q9NRG9,Q53GS7,Q9NXE4 38 9.58e-03 75 13 2 0.154 0.027 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 Q9BTX1,Q9NRG9 38 9.96e-03 55 13 2 0.154 0.036 GO:0000794 CC 1 condensed nuclear chromosome 1 P63279,P18754 38 1.03e-02 153 13 2 0.154 0.013 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 Q96SK2,P18754 38 1.03e-02 56 13 2 0.154 0.036 GO:1901800 BP 1 positive regulation of proteasomal protein catabolic process 1 P63165,P61956 38 1.04e-02 5787 13 12 0.923 0.002 GO:0044446 CC 1 intracellular organelle part 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.07e-02 225 13 3 0.231 0.013 GO:0031625 MF 1 ubiquitin protein ligase binding 1 P63279,P63165,P61956 38 1.10e-02 2062 13 6 0.462 0.003 TF:M07052_0 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 0 1 Q9BTX1,Q53GS7,Q9NXE4,Q9UBU9,Q9HC62,P18754 38 1.11e-02 159 13 2 0.154 0.013 TF:M01248_1 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 1 1 Q96SK2,P18754 38 1.11e-02 58 13 2 0.154 0.034 GO:0010827 BP 1 regulation of glucose transport 1 Q9BTX1,Q9NRG9 38 1.13e-02 229 13 3 0.231 0.013 GO:0044389 MF 1 ubiquitin-like protein ligase binding 1 P63279,P63165,P61956 38 1.19e-02 428 13 3 0.231 0.007 MI:mmu-miR-666-3p mi 1 MI:mmu-miR-666-3p 1 P63279,Q6NUQ4,P18754 38 1.20e-02 9057 13 13 1.000 0.001 TF:M00794_0 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.21e-02 430 13 3 0.231 0.007 MI:mmu-miR-686 mi 1 MI:mmu-miR-686 1 Q9NRG9,Q9UBU9,P18754 38 1.24e-02 5877 13 12 0.923 0.002 GO:0044422 CC 1 organelle part 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.25e-02 86 13 2 0.154 0.023 REAC:211000 rea 1 Gene Silencing by RNA 1 Q9BTX1,Q9NRG9 38 1.32e-02 13 13 1 0.077 0.077 TF:M06811_0 tf 1 Factor: ZNF528; motif: KGTTAMGGCCGM; match class: 0 1 Q53GS7 38 1.33e-02 2 13 1 0.077 0.500 GO:0070631 BP 1 spindle pole body localization 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0031081 BP 1 nuclear pore distribution 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0051664 BP 1 nuclear pore localization 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0070632 BP 1 establishment of spindle pole body localization 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0030474 BP 1 spindle pole body duplication 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0051300 BP 1 spindle pole body organization 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0071790 BP 1 establishment of spindle pole body localization to nuclear envelope 1 Q9BTX1 38 1.33e-02 2 13 1 0.077 0.500 GO:0071789 BP 1 spindle pole body localization to nuclear envelope 1 Q9BTX1 38 1.35e-02 1169 13 6 0.462 0.005 REAC:392499 rea 1 Metabolism of proteins 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9HC62,P61956 38 1.38e-02 6510 13 11 0.846 0.002 TF:M07053_0 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754 38 1.39e-02 65 13 2 0.154 0.031 GO:0075733 BP 1 intracellular transport of virus 1 Q9BTX1,Q9NRG9 38 1.39e-02 91 13 2 0.154 0.022 REAC:3371556 rea 1 Cellular response to heat stress 1 Q9BTX1,Q9NRG9 38 1.42e-02 272 13 3 0.231 0.011 REAC:73894 rea 1 DNA Repair 1 P63279,P63165,P61956 38 1.42e-02 14 13 1 0.077 0.071 TF:M04060_0 tf 1 Factor: PAX1; motif: CGTCACGCWTGANTGMN; match class: 0 1 P63279 38 1.42e-02 14 13 1 0.077 0.071 TF:M00490_1 tf 1 Factor: Bach2; motif: SRTGAGTCANC; match class: 1 1 Q9NXE4 38 1.43e-02 66 13 2 0.154 0.030 GO:1902581 BP 1 multi-organism cellular localization 1 Q9BTX1,Q9NRG9 38 1.43e-02 66 13 2 0.154 0.030 GO:1902583 BP 1 multi-organism intracellular transport 1 Q9BTX1,Q9NRG9 38 1.45e-02 2 13 1 0.077 0.500 CORUM:1056 cor 1 ZNF198-SUMO1 complex 1 P63165 38 1.45e-02 93 13 2 0.154 0.022 REAC:68875 rea 1 Mitotic Prophase 1 Q9BTX1,Q9NRG9 38 1.47e-02 67 13 2 0.154 0.030 GO:0046794 BP 1 transport of virus 1 Q9BTX1,Q9NRG9 38 1.49e-02 4563 13 9 0.692 0.002 TF:M00414_0 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9NXE4,O14524,P18754,P61956 38 1.51e-02 68 13 2 0.154 0.029 GO:0006998 BP 1 nuclear envelope organization 1 Q9BTX1,Q9NRG9 38 1.52e-02 188 13 2 0.154 0.011 TF:M03877_1 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 1 1 P63279,Q9NXE4 38 1.59e-02 4605 13 9 0.692 0.002 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q9BTX1,Q9NRG9,P63165,Q53GS7,Q6NUQ4,Q96SK2,Q9HC62,O14524,P61956 38 1.60e-02 70 13 2 0.154 0.029 GO:0044766 BP 1 multi-organism transport 1 Q9BTX1,Q9NRG9 38 1.60e-02 70 13 2 0.154 0.029 GO:1902579 BP 1 multi-organism localization 1 Q9BTX1,Q9NRG9 38 1.63e-02 195 13 2 0.154 0.010 TF:M06602_0 tf 1 Factor: ZNF669; motif: NCGATTTTAWTT; match class: 0 1 Q96SK2,P61956 38 1.63e-02 4622 13 9 0.692 0.002 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 1.66e-02 547 13 4 0.308 0.007 REAC:1640170 rea 1 Cell Cycle 1 Q9BTX1,Q9NRG9,P63279,P63165 38 1.73e-02 559 13 3 0.231 0.005 TF:M02063_1 tf 1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 1 Q9NRG9,P63165,P18754 38 1.74e-02 73 13 2 0.154 0.027 GO:1900034 BP 1 regulation of cellular response to heat 1 Q9BTX1,Q9NRG9 38 1.79e-02 3011 13 7 0.538 0.002 TF:M02102_0 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 0 1 Q9BTX1,Q53GS7,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,P18754 38 1.89e-02 76 13 2 0.154 0.026 GO:0032434 BP 1 regulation of proteasomal ubiquitin-dependent protein catabolic process 1 P63165,P61956 38 1.92e-02 19 13 1 0.077 0.053 TF:M06041_0 tf 1 Factor: ZNF276; motif: NATGAGACGM; match class: 0 1 O14524 38 1.98e-02 78 13 2 0.154 0.026 GO:0008645 BP 1 hexose transport 1 Q9BTX1,Q9NRG9 38 1.98e-02 78 13 2 0.154 0.026 GO:0015758 BP 1 glucose transport 1 Q9BTX1,Q9NRG9 38 2.00e-02 3 13 1 0.077 0.333 GO:0044614 CC 1 nuclear pore cytoplasmic filaments 1 Q53GS7 38 2.00e-02 3 13 1 0.077 0.333 GO:0071535 MF 1 RING-like zinc finger domain binding 1 P63279 38 2.00e-02 3 13 1 0.077 0.333 GO:0070139 MF 1 SUMO-specific endopeptidase activity 1 Q9HC62 38 2.00e-02 3 13 1 0.077 0.333 GO:0000822 MF 1 inositol hexakisphosphate binding 1 Q53GS7 38 2.00e-02 3 13 1 0.077 0.333 GO:1903817 BP 1 negative regulation of voltage-gated potassium channel activity 1 P63165 38 2.00e-02 3 13 1 0.077 0.333 GO:1902260 BP 1 negative regulation of delayed rectifier potassium channel activity 1 P63165 38 2.00e-02 3 13 1 0.077 0.333 GO:0070137 MF 1 ubiquitin-like protein-specific endopeptidase activity 1 Q9HC62 38 2.00e-02 9421 13 13 1.000 0.001 TF:M00803_1 tf 1 Factor: E2F; motif: GGCGSG; match class: 1 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 2.02e-02 20 13 1 0.077 0.050 TF:M06616_0 tf 1 Factor: ZNF594; motif: CAGGGCCACGGA; match class: 0 1 P63165 38 2.03e-02 79 13 2 0.154 0.025 GO:0015749 BP 1 monosaccharide transport 1 Q9BTX1,Q9NRG9 38 2.09e-02 9455 13 13 1.000 0.001 TF:M02114_0 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 2.09e-02 9455 13 13 1.000 0.001 TF:M07056_0 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 0 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 2.10e-02 113 13 2 0.154 0.018 REAC:72306 rea 1 tRNA processing 1 Q9BTX1,Q9NRG9 38 2.16e-02 3114 13 7 0.538 0.002 TF:M03983_0 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 0 1 Q9NRG9,P63279,P63165,Q6NUQ4,Q96SK2,Q9UBU9,P18754 38 2.17e-02 3 13 1 0.077 0.333 CORUM:5755 cor 1 SUMO1-SUA1-UBA2 complex 1 P63165 38 2.17e-02 3 13 1 0.077 0.333 CORUM:1552 cor 1 TNPO2-RAN-NXF1 complex 1 Q9UBU9 38 2.17e-02 3 13 1 0.077 0.333 CORUM:3634 cor 1 NR3C2-UBC9-SRC-1 complex 1 P63279 38 2.17e-02 3 13 1 0.077 0.333 CORUM:1348 cor 1 GLE1-NUPL2-NUP155 complex 1 Q53GS7 38 2.19e-02 228 13 2 0.154 0.009 TF:M01306_1 tf 1 Factor: ZABC1; motif: ATTCCNAC; match class: 1 1 P63165,P18754 38 2.24e-02 83 13 2 0.154 0.024 GO:0008643 BP 1 carbohydrate transport 1 Q9BTX1,Q9NRG9 38 2.32e-02 23 13 1 0.077 0.043 TF:M03993_0 tf 1 Factor: SPDEF; motif: GCAGNAAGAMGTAAMM; match class: 0 1 Q96SK2 38 2.35e-02 85 13 2 0.154 0.024 GO:0034605 BP 1 cellular response to heat 1 Q9BTX1,Q9NRG9 38 2.36e-02 2096 13 7 0.538 0.003 GO:0043234 CC 1 protein complex 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9UBU9,Q9HC62 38 2.39e-02 239 13 2 0.154 0.008 TF:M06564_0 tf 1 Factor: ZNF578; motif: KGGACGKGAAAA; match class: 0 1 Q9NXE4,O14524 38 2.44e-02 11 13 1 0.077 0.091 REAC:877312 rea 1 Regulation of IFNG signaling 1 P63165 38 2.62e-02 26 13 1 0.077 0.038 TF:M06260_0 tf 1 Factor: ZNF91; motif: GTKAAGCCRM; match class: 0 1 P61956 38 2.70e-02 3247 13 7 0.538 0.002 TF:M02119_1 tf 1 Factor: T3Rbeta; motif: RRGNNANNNGAGGWCAN; match class: 1 1 Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P61956 38 2.71e-02 346 13 3 0.231 0.009 REAC:5663205 rea 1 Infectious disease 1 Q9BTX1,Q9NRG9,P18754 38 2.72e-02 27 13 1 0.077 0.037 TF:M06269_0 tf 1 Factor: ZNF569; motif: NGTGTTAAAAAA; match class: 0 1 P18754 38 2.76e-02 1193 13 4 0.308 0.003 TF:M00998_0 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 0 1 Q53GS7,Q6NUQ4,O14524,P61956 38 2.82e-02 132 13 2 0.154 0.015 REAC:168273 rea 1 Influenza Viral RNA Transcription and Replication 1 Q9BTX1,Q9NRG9 38 2.88e-02 264 13 2 0.154 0.008 TF:M00482_1 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 1 1 Q53GS7,Q96SK2 38 2.92e-02 29 13 1 0.077 0.034 TF:M06686_1 tf 1 Factor: PRDM9; motif: TTTGTGGAGA; match class: 1 1 Q9BTX1 38 2.95e-02 684 13 3 0.231 0.004 TF:M04148_0 tf 1 Factor: TFAP2A; motif: NGCCCYNNGGGCN; match class: 0 1 P63279,Q9NXE4,Q9UBU9 38 2.98e-02 96 13 2 0.154 0.021 GO:0061136 BP 1 regulation of proteasomal protein catabolic process 1 P63165,P61956 38 3.10e-02 98 13 2 0.154 0.020 GO:0000793 CC 1 condensed chromosome 1 P63279,P18754 38 3.14e-02 140 13 2 0.154 0.014 REAC:168255 rea 1 Influenza Life Cycle 1 Q9BTX1,Q9NRG9 38 3.16e-02 1244 13 4 0.308 0.003 TF:M00929_0 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 0 1 Q9BTX1,P63279,Q9NXE4,O14524 38 3.19e-02 4185 13 8 0.615 0.002 TF:M03797_1 tf 1 Factor: Msx-2; motif: TWWTTGGDGABN; match class: 1 1 P63165,Q53GS7,Q9NXE4,Q96SK2,Q9HC62,O14524,P18754,P61956 38 3.22e-02 100 13 2 0.154 0.020 GO:0009408 BP 1 response to heat 1 Q9BTX1,Q9NRG9 38 3.27e-02 4430 13 10 0.769 0.002 GO:0005634 CC 1 nucleus 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 3.32e-02 33 13 1 0.077 0.030 TF:M06334_0 tf 1 Factor: ZNF782; motif: NGTTAAAAAASA; match class: 0 1 Q9HC62 38 3.33e-02 5 13 1 0.077 0.200 GO:0005087 MF 1 Ran guanyl-nucleotide exchange factor activity 1 P18754 38 3.33e-02 5 13 1 0.077 0.200 GO:0006685 BP 1 sphingomyelin catabolic process 1 Q9NXE4 38 3.33e-02 5 13 1 0.077 0.200 GO:0004767 MF 1 sphingomyelin phosphodiesterase activity 1 Q9NXE4 38 3.38e-02 288 13 2 0.154 0.007 TF:M01209_1 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 1 1 P63279,P63165 38 3.42e-02 103 13 2 0.154 0.019 GO:0006997 BP 1 nucleus organization 1 Q9BTX1,Q9NRG9 38 3.53e-02 5164 13 9 0.692 0.002 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q9BTX1,P63279,P63165,Q53GS7,Q9NXE4,Q96SK2,Q9HC62,O14524,P18754 38 3.59e-02 738 13 3 0.231 0.004 TF:M06537_0 tf 1 Factor: CTCFL; motif: NSGTGGGCGG; match class: 0 1 Q9BTX1,Q9UBU9,Q9HC62 38 3.59e-02 5 13 1 0.077 0.200 CORUM:5260 cor 1 TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex 1 P63165 38 3.59e-02 2649 13 6 0.462 0.002 TF:M04632_1 tf 1 Factor: SREBP-1; motif: NNNGTGGGGTGAN; match class: 1 1 P63165,Q53GS7,Q6NUQ4,Q9HC62,P18754,P61956 38 3.62e-02 36 13 1 0.077 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 Q96SK2 38 3.62e-02 151 13 2 0.154 0.013 REAC:168254 rea 1 Influenza Infection 1 Q9BTX1,Q9NRG9 38 3.80e-02 307 13 2 0.154 0.007 TF:M01816_1 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 1 P63279,P63165 38 3.85e-02 2689 13 6 0.462 0.002 TF:M04144_0 tf 1 Factor: TEAD3; motif: RCATTCCW; match class: 0 1 P63165,Q53GS7,Q9UBU9,Q9HC62,O14524,P18754 38 3.88e-02 110 13 2 0.154 0.018 GO:0031047 BP 1 gene silencing by RNA 1 Q9BTX1,Q9NRG9 38 3.91e-02 39 13 1 0.077 0.026 TF:M03930_0 tf 1 Factor: ZIC1; motif: GACCCCCYGCTGTG; match class: 0 1 Q6NUQ4 38 3.99e-02 6 13 1 0.077 0.167 GO:0006449 BP 1 regulation of translational termination 1 Q53GS7 38 4.07e-02 319 13 2 0.154 0.006 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q9NRG9,Q9NXE4 38 4.10e-02 874 13 6 0.462 0.007 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 P63279,P63165,Q9UBU9,Q9HC62,P18754,P61956 38 4.11e-02 41 13 1 0.077 0.024 TF:M05512_0 tf 1 Factor: ZNF575; motif: NGGTGGGGGGGC; match class: 0 1 Q9NXE4 38 4.21e-02 7364 13 11 0.846 0.001 TF:M00448_1 tf 1 Factor: Zic1; motif: KGGGTGGTC; match class: 1 1 Q9BTX1,Q9NRG9,P63279,Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P18754 38 4.28e-02 1366 13 4 0.308 0.003 TF:M00264_0 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 0 1 Q9BTX1,P63165,Q6NUQ4,Q9NXE4 38 4.31e-02 43 13 1 0.077 0.023 TF:M05637_0 tf 1 Factor: ZNF189; motif: KGTTGSGGGATY; match class: 0 1 Q6NUQ4 38 4.32e-02 7385 13 11 0.846 0.001 TF:M00033_1 tf 1 Factor: p300; motif: NNNGGGAGTNNNNS; match class: 1 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q9NXE4,Q96SK2,Q9UBU9,Q9HC62,O14524,P61956 38 4.34e-02 2032 13 5 0.385 0.002 TF:M07375_0 tf 1 Factor: BCL-6; motif: TTCCTAGAAA; match class: 0 1 Q9BTX1,Q9NRG9,Q6NUQ4,Q9NXE4,Q96SK2 38 4.40e-02 333 13 2 0.154 0.006 TF:M06526_0 tf 1 Factor: ZNF555; motif: GAGCHGGCCC; match class: 0 1 Q9BTX1,Q9HC62 38 4.46e-02 373 13 3 0.231 0.008 GO:0016032 BP 1 viral process 1 Q9BTX1,Q9NRG9,P18754 38 4.46e-02 2047 13 5 0.385 0.002 TF:M01816_0 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 0 1 P63279,P63165,Q53GS7,Q9UBU9,Q9HC62 38 4.49e-02 6342 13 10 0.769 0.002 TF:M01692_0 tf 1 Factor: LTF; motif: GKVACTTNC; match class: 0 1 Q9BTX1,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9UBU9,Q9HC62,P18754,P61956 38 4.49e-02 3578 13 7 0.538 0.002 TF:M04141_0 tf 1 Factor: TEAD1; motif: NRCATTCCWN; match class: 0 1 P63279,P63165,Q53GS7,Q9UBU9,Q9HC62,O14524,P18754 38 4.50e-02 45 13 1 0.077 0.022 TF:M06555_0 tf 1 Factor: ZNF721; motif: NGGTGTGGGTGC; match class: 0 1 Q9NXE4 38 4.50e-02 45 13 1 0.077 0.022 TF:M07090_0 tf 1 Factor: c-Fos; motif: NNTGASTCATN; match class: 0 1 Q53GS7 38 4.52e-02 119 13 2 0.154 0.017 GO:0009266 BP 1 response to temperature stimulus 1 Q9BTX1,Q9NRG9 38 4.52e-02 338 13 2 0.154 0.006 TF:M03548_1 tf 1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 1 P63165,Q96SK2 38 4.52e-02 375 13 3 0.231 0.008 GO:0044764 BP 1 multi-organism cellular process 1 Q9BTX1,Q9NRG9,P18754 38 4.70e-02 1212 13 5 0.385 0.004 GO:0033554 BP 1 cellular response to stress 1 Q9BTX1,Q9NRG9,P63279,P63165,P61956 38 4.80e-02 48 13 1 0.077 0.021 TF:M06545_0 tf 1 Factor: ZNF485; motif: NGGGAKGGGGGW; match class: 0 1 P63279 38 4.83e-02 384 13 3 0.231 0.008 GO:0006281 BP 1 DNA repair 1 P63279,P63165,P61956 38 4.90e-02 386 13 3 0.231 0.008 GO:0044419 BP 1 interspecies interaction between organisms 1 Q9BTX1,Q9NRG9,P18754 38 4.90e-02 386 13 3 0.231 0.008 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q9BTX1,Q9NRG9,P18754 38 4.95e-02 3647 13 7 0.538 0.002 TF:M00380_1 tf 1 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC; match class: 1 1 Q53GS7,Q6NUQ4,Q9NXE4,Q96SK2,Q9HC62,O14524,P18754 38 5.00e-02 6671 13 12 0.923 0.002 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q9BTX1,Q9NRG9,P63279,P63165,Q53GS7,Q6NUQ4,Q9NXE4,Q9UBU9,Q9HC62,O14524,P18754,P61956 38 5.00e-02 152 13 7 0.538 0.046 KEGG:03013 keg 1 RNA transport 1 Q9BTX1,Q9NRG9,P63279,P63165,Q9UBU9,Q9HC62,P61956 38 5.00e-02 1 13 1 0.077 1.000 HP:0100334 hp 1 Unilateral cleft palate 1 P63165 38 5.00e-02 1 13 1 0.077 1.000 HP:0007277 hp 1 Paucity of anterior horn motor neurons 1 Q53GS7 38 5.00e-02 7 13 1 0.077 0.143 CORUM:814 cor 1 Postsplicing complex 1 Q9UBU9 38 5.00e-02 180 13 2 0.154 0.011 REAC:425407 rea 1 SLC-mediated transmembrane transport 1 Q9BTX1,Q9NRG9 38 5.00e-02 1 13 1 0.077 1.000 HP:0004571 hp 1 Widening of cervical spinal canal 1 Q53GS7 38 5.00e-02 6 13 1 0.077 0.167 OMIM:253310 omi 1 Lethal Congenital Contracture Syndrome 1 Q53GS7 38 5.00e-02 906 13 6 0.462 0.007 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P63279,P63165,Q9UBU9,Q9HC62,P18754,P61956 38 5.00e-02 1 13 1 0.077 1.000 HP:0100333 hp 1 Unilateral cleft lip 1 P63165 39 1.08e-02 661 3 2 0.667 0.003 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 O43156,Q6YHU6 39 2.55e-02 362 3 2 0.667 0.006 MI:hsa-miR-34b* mi 1 MI:hsa-miR-34b* 1 O43156,Q96QU8 39 3.31e-02 413 3 2 0.667 0.005 MI:hsa-miR-541 mi 1 MI:hsa-miR-541 1 O43156,Q96QU8 39 3.78e-02 442 3 2 0.667 0.005 MI:hsa-miR-182 mi 1 MI:hsa-miR-182 1 O43156,Q96QU8 39 4.38e-02 7 3 1 0.333 0.143 GO:0031931 CC 1 TORC1 complex 1 O43156 39 5.00e-02 509 3 2 0.667 0.004 MI:hsa-miR-885-3p mi 1 MI:hsa-miR-885-3p 1 O43156,Q96QU8 39 5.00e-02 94 3 2 0.667 0.021 TF:M06284_0 tf 1 Factor: Cos52; motif: NNGTSSTAAAGC; match class: 0 1 O43156,Q6YHU6 39 5.00e-02 8 3 1 0.333 0.125 GO:0031932 CC 1 TORC2 complex 1 O43156 40 4.97e-04 1 2 1 0.500 1.000 GO:0004476 MF 1 mannose-6-phosphate isomerase activity 1 P34949 40 9.94e-04 2 2 1 0.500 0.500 GO:0042584 CC 1 chromaffin granule membrane 1 P30626 40 9.94e-04 2 2 1 0.500 0.500 GO:0042583 CC 1 chromaffin granule 1 P30626 40 1.26e-03 8 2 1 0.500 0.125 TF:M04622_1 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 1 1 P34949 40 1.49e-03 3 2 1 0.500 0.333 GO:0009298 BP 1 GDP-mannose biosynthetic process 1 P34949 40 1.49e-03 3 2 1 0.500 0.333 GO:0010459 BP 1 negative regulation of heart rate 1 P30626 40 1.99e-03 4 2 1 0.500 0.250 GO:0097577 BP 1 sequestering of iron ion 1 P30626 40 1.99e-03 4 2 1 0.500 0.250 GO:1901844 BP 1 regulation of cell communication by electrical coupling involved in cardiac conduction 1 P30626 40 1.99e-03 4 2 1 0.500 0.250 GO:1901841 BP 1 regulation of high voltage-gated calcium channel activity 1 P30626 40 1.99e-03 4 2 1 0.500 0.250 GO:0006880 BP 1 intracellular sequestering of iron ion 1 P30626 40 1.99e-03 4 2 1 0.500 0.250 GO:1901077 BP 1 regulation of relaxation of muscle 1 P30626 40 2.49e-03 5 2 1 0.500 0.200 GO:0019673 BP 1 GDP-mannose metabolic process 1 P34949 40 2.51e-03 16 2 1 0.500 0.062 TF:M07427_1 tf 1 Factor: NURR1; motif: AAAGGTCANN; match class: 1 1 P34949 40 2.70e-03 5 2 1 0.500 0.200 REAC:446205 rea 1 Synthesis of GDP-mannose 1 P34949 40 3.25e-03 6 2 1 0.500 0.167 REAC:425561 rea 1 Sodium/Calcium exchangers 1 P30626 40 3.48e-03 7 2 1 0.500 0.143 GO:0010649 BP 1 regulation of cell communication by electrical coupling 1 P30626 40 3.48e-03 7 2 1 0.500 0.143 GO:0045822 BP 1 negative regulation of heart contraction 1 P30626 40 3.98e-03 8 2 1 0.500 0.125 GO:0060315 BP 1 negative regulation of ryanodine-sensitive calcium-release channel activity 1 P30626 40 3.98e-03 8 2 1 0.500 0.125 GO:0051280 BP 1 negative regulation of release of sequestered calcium ion into cytosol 1 P30626 40 4.45e-03 850 2 2 1.000 0.002 TF:M04333_1 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 1 1 P30626,P34949 40 4.47e-03 9 2 1 0.500 0.111 GO:0051284 BP 1 positive regulation of sequestering of calcium ion 1 P30626 40 4.47e-03 9 2 1 0.500 0.111 GO:0010523 BP 1 negative regulation of calcium ion transport into cytosol 1 P30626 40 4.71e-03 30 2 1 0.500 0.033 TF:M06475_1 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 1 1 P30626 40 4.97e-03 10 2 1 0.500 0.100 GO:0016861 MF 1 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1 P34949 40 5.47e-03 11 2 1 0.500 0.091 GO:0090281 BP 1 negative regulation of calcium ion import 1 P30626 40 5.47e-03 11 2 1 0.500 0.091 GO:1903523 BP 1 negative regulation of blood circulation 1 P30626 40 5.95e-03 11 2 1 0.500 0.091 REAC:418359 rea 1 Reduction of cytosolic Ca++ levels 1 P30626 40 5.96e-03 12 2 1 0.500 0.083 GO:1901385 BP 1 regulation of voltage-gated calcium channel activity 1 P30626 40 5.96e-03 12 2 1 0.500 0.083 GO:0090075 BP 1 relaxation of muscle 1 P30626 40 5.96e-03 12 2 1 0.500 0.083 GO:0050849 BP 1 negative regulation of calcium-mediated signaling 1 P30626 40 7.15e-03 1 2 1 0.500 1.000 OMIM:602579 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ib; CDG1B;;CDG Ib; CDGIb;;CDG, GASTROINTESTINAL TYPE;;MANNOSEPHOSPHATE ISOMERASE DEFICIENCY;;MPI DEFICIENCY;;PROTEIN-LOSING ENTEROPATHY-HEPATIC FIBROSIS SYNDROME;;SAGUENAY-LAC SAINT-JEAN SYNDROME; SLSJ SYNDROME 1 P34949 40 7.45e-03 15 2 1 0.500 0.067 GO:1901020 BP 1 negative regulation of calcium ion transmembrane transporter activity 1 P30626 40 7.45e-03 15 2 1 0.500 0.067 GO:1903170 BP 1 negative regulation of calcium ion transmembrane transport 1 P30626 40 7.92e-03 3 2 1 0.500 0.333 HP:0002243 hp 1 Protein-losing enteropathy 1 P34949 40 7.95e-03 16 2 1 0.500 0.062 GO:0086064 BP 1 cell communication by electrical coupling involved in cardiac conduction 1 P30626 40 7.95e-03 16 2 1 0.500 0.062 GO:0010880 BP 1 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1 P30626 40 7.95e-03 16 2 1 0.500 0.062 GO:2001258 BP 1 negative regulation of cation channel activity 1 P30626 40 8.45e-03 17 2 1 0.500 0.059 GO:2000272 BP 1 negative regulation of receptor activity 1 P30626 40 8.45e-03 17 2 1 0.500 0.059 GO:0014808 BP 1 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1 P30626 40 8.45e-03 17 2 1 0.500 0.059 GO:1903514 BP 1 calcium ion transport from endoplasmic reticulum to cytosol 1 P30626 40 8.94e-03 18 2 1 0.500 0.056 GO:0070296 BP 1 sarcoplasmic reticulum calcium ion transport 1 P30626 40 8.94e-03 18 2 1 0.500 0.056 GO:0060314 BP 1 regulation of ryanodine-sensitive calcium-release channel activity 1 P30626 40 8.94e-03 18 2 1 0.500 0.056 GO:0004198 MF 1 calcium-dependent cysteine-type endopeptidase activity 1 P30626 40 9.44e-03 19 2 1 0.500 0.053 GO:0030315 CC 1 T-tubule 1 P30626 40 9.44e-03 19 2 1 0.500 0.053 GO:0086004 BP 1 regulation of cardiac muscle cell contraction 1 P30626 40 9.44e-03 19 2 1 0.500 0.053 GO:0009226 BP 1 nucleotide-sugar biosynthetic process 1 P34949 40 9.44e-03 19 2 1 0.500 0.053 GO:0010644 BP 1 cell communication by electrical coupling 1 P30626 40 1.04e-02 21 2 1 0.500 0.048 GO:1903115 BP 1 regulation of actin filament-based movement 1 P30626 40 1.04e-02 21 2 1 0.500 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 P30626 40 1.07e-02 68 2 1 0.500 0.015 TF:M06425_0 tf 1 Factor: ZNF227; motif: NSAAGGGTGARA; match class: 0 1 P30626 40 1.09e-02 22 2 1 0.500 0.045 GO:0005246 MF 1 calcium channel regulator activity 1 P30626 40 1.13e-02 21 2 1 0.500 0.048 REAC:418360 rea 1 Platelet calcium homeostasis 1 P30626 40 1.18e-02 75 2 1 0.500 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 P30626 40 1.24e-02 25 2 1 0.500 0.040 GO:0009225 BP 1 nucleotide-sugar metabolic process 1 P34949 40 1.28e-02 82 2 1 0.500 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 P34949 40 1.30e-02 83 2 1 0.500 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 P34949 40 1.32e-02 5 2 1 0.500 0.200 HP:0001929 hp 1 Reduced factor XI activity 1 P34949 40 1.34e-02 27 2 1 0.500 0.037 GO:0086003 BP 1 cardiac muscle cell contraction 1 P30626 40 1.34e-02 1476 2 2 1.000 0.001 TF:M02110_1 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 1 1 P30626,P34949 40 1.39e-02 28 2 1 0.500 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 P30626 40 1.49e-02 30 2 1 0.500 0.033 GO:1904063 BP 1 negative regulation of cation transmembrane transport 1 P30626 40 1.49e-02 30 2 1 0.500 0.033 GO:0016529 CC 1 sarcoplasmic reticulum 1 P30626 40 1.54e-02 31 2 1 0.500 0.032 GO:0086065 BP 1 cell communication involved in cardiac conduction 1 P30626 40 1.59e-02 32 2 1 0.500 0.031 GO:0006879 BP 1 cellular iron ion homeostasis 1 P30626 40 1.60e-02 102 2 1 0.500 0.010 TF:M01841_1 tf 1 Factor: ERR1; motif: MCNTGACCTTKRRNN; match class: 1 1 P34949 40 1.63e-02 104 2 1 0.500 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 P30626 40 1.64e-02 33 2 1 0.500 0.030 GO:0016528 CC 1 sarcoplasm 1 P30626 40 1.72e-02 1672 2 2 1.000 0.001 TF:M01725_0 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 0 1 P30626,P34949 40 1.74e-02 35 2 1 0.500 0.029 GO:0055117 BP 1 regulation of cardiac muscle contraction 1 P30626 40 1.74e-02 35 2 1 0.500 0.029 GO:0051279 BP 1 regulation of release of sequestered calcium ion into cytosol 1 P30626 40 1.74e-02 35 2 1 0.500 0.029 GO:0032410 BP 1 negative regulation of transporter activity 1 P30626 40 1.76e-02 1688 2 2 1.000 0.001 TF:M07426_0 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 0 1 P30626,P34949 40 1.79e-02 36 2 1 0.500 0.028 GO:0055072 BP 1 iron ion homeostasis 1 P30626 40 1.79e-02 36 2 1 0.500 0.028 GO:0034766 BP 1 negative regulation of ion transmembrane transport 1 P30626 40 1.84e-02 37 2 1 0.500 0.027 GO:0050848 BP 1 regulation of calcium-mediated signaling 1 P30626 40 1.85e-02 7 2 1 0.500 0.143 HP:0001976 hp 1 Reduced antithrombin III activity 1 P34949 40 1.89e-02 38 2 1 0.500 0.026 GO:0042383 CC 1 sarcolemma 1 P30626 40 1.89e-02 38 2 1 0.500 0.026 GO:0034763 BP 1 negative regulation of transmembrane transport 1 P30626 40 1.94e-02 39 2 1 0.500 0.026 GO:1901019 BP 1 regulation of calcium ion transmembrane transporter activity 1 P30626 40 1.94e-02 39 2 1 0.500 0.026 GO:0002027 BP 1 regulation of heart rate 1 P30626 40 1.99e-02 40 2 1 0.500 0.025 GO:0010522 BP 1 regulation of calcium ion transport into cytosol 1 P30626 40 2.05e-02 38 2 1 0.500 0.026 REAC:5578775 rea 1 Ion homeostasis 1 P30626 40 2.08e-02 42 2 1 0.500 0.024 GO:0016860 MF 1 intramolecular oxidoreductase activity 1 P34949 40 2.08e-02 42 2 1 0.500 0.024 GO:0030667 CC 1 secretory granule membrane 1 P30626 40 2.13e-02 43 2 1 0.500 0.023 GO:0090279 BP 1 regulation of calcium ion import 1 P30626 40 2.19e-02 140 2 1 0.500 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 P34949 40 2.23e-02 45 2 1 0.500 0.022 GO:0030018 CC 1 Z disc 1 P30626 40 2.23e-02 45 2 1 0.500 0.022 GO:1903779 BP 1 regulation of cardiac conduction 1 P30626 40 2.28e-02 46 2 1 0.500 0.022 GO:0006942 BP 1 regulation of striated muscle contraction 1 P30626 40 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 P34949 40 2.37e-02 9 2 1 0.500 0.111 HP:0000825 hp 1 Hyperinsulinemic hypoglycemia 1 P34949 40 2.37e-02 9 2 1 0.500 0.111 HP:0010988 hp 1 Abnormality of the extrinsic pathway 1 P34949 40 2.43e-02 45 2 1 0.500 0.022 REAC:936837 rea 1 Ion transport by P-type ATPases 1 P30626 40 2.48e-02 50 2 1 0.500 0.020 GO:0051282 BP 1 regulation of sequestering of calcium ion 1 P30626 40 2.48e-02 50 2 1 0.500 0.020 GO:0051209 BP 1 release of sequestered calcium ion into cytosol 1 P30626 40 2.48e-02 50 2 1 0.500 0.020 GO:0051283 BP 1 negative regulation of sequestering of calcium ion 1 P30626 40 2.50e-02 1 2 1 0.500 1.000 CORUM:5372 cor 1 SRI homodimer complex 1 P30626 40 2.53e-02 51 2 1 0.500 0.020 GO:1902656 BP 1 calcium ion import into cytosol 1 P30626 40 2.53e-02 51 2 1 0.500 0.020 GO:0097553 BP 1 calcium ion transmembrane import into cytosol 1 P30626 40 2.57e-02 2042 2 2 1.000 0.001 TF:M01067_0 tf 1 Factor: Gfi1; motif: NNAAATCANNGSN; match class: 0 1 P30626,P34949 40 2.58e-02 52 2 1 0.500 0.019 GO:0043271 BP 1 negative regulation of ion transport 1 P30626 40 2.58e-02 52 2 1 0.500 0.019 GO:1903169 BP 1 regulation of calcium ion transmembrane transport 1 P30626 40 2.63e-02 53 2 1 0.500 0.019 GO:0051208 BP 1 sequestering of calcium ion 1 P30626 40 2.63e-02 53 2 1 0.500 0.019 GO:0031674 CC 1 I band 1 P30626 40 2.64e-02 2068 2 2 1.000 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 P30626,P34949 40 2.73e-02 55 2 1 0.500 0.018 GO:2001257 BP 1 regulation of cation channel activity 1 P30626 40 2.76e-02 177 2 1 0.500 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 P30626 40 2.78e-02 56 2 1 0.500 0.018 GO:0046916 BP 1 cellular transition metal ion homeostasis 1 P30626 40 2.80e-02 52 2 1 0.500 0.019 REAC:446219 rea 1 Synthesis of substrates in N-glycan biosythesis 1 P34949 40 2.83e-02 57 2 1 0.500 0.018 GO:0099106 MF 1 ion channel regulator activity 1 P30626 40 2.83e-02 57 2 1 0.500 0.018 GO:0060048 BP 1 cardiac muscle contraction 1 P30626 40 2.86e-02 4 2 1 0.500 0.250 OMIM:212065 omi 1 Congenital Disorder of Glycosylation Type I 1 P34949 40 2.98e-02 60 2 1 0.500 0.017 GO:0060402 BP 1 calcium ion transport into cytosol 1 P30626 40 3.03e-02 61 2 1 0.500 0.016 GO:0070252 BP 1 actin-mediated cell contraction 1 P30626 40 3.17e-02 64 2 1 0.500 0.016 GO:0055076 BP 1 transition metal ion homeostasis 1 P30626 40 3.27e-02 66 2 1 0.500 0.015 GO:0010469 BP 1 regulation of receptor activity 1 P30626 40 3.32e-02 67 2 1 0.500 0.015 GO:0044325 MF 1 ion channel binding 1 P30626 40 3.32e-02 67 2 1 0.500 0.015 GO:0051238 BP 1 sequestering of metal ion 1 P30626 40 3.37e-02 68 2 1 0.500 0.015 GO:0006937 BP 1 regulation of muscle contraction 1 P30626 40 3.40e-02 218 2 1 0.500 0.005 TF:M07139_0 tf 1 Factor: USF2; motif: RYCAYGTGACY; match class: 0 1 P34949 40 3.42e-02 69 2 1 0.500 0.014 GO:0001508 BP 1 action potential 1 P30626 40 3.42e-02 69 2 1 0.500 0.014 GO:0060401 BP 1 cytosolic calcium ion transport 1 P30626 40 3.42e-02 13 2 1 0.500 0.077 HP:0003642 hp 1 Type I transferrin isoform profile 1 P34949 40 3.50e-02 65 2 1 0.500 0.015 REAC:446193 rea 1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 1 P34949 40 3.50e-02 65 2 1 0.500 0.015 REAC:425393 rea 1 Transport of inorganic cations/anions and amino acids/oligopeptides 1 P30626 40 3.67e-02 74 2 1 0.500 0.014 GO:0004197 MF 1 cysteine-type endopeptidase activity 1 P30626 40 3.72e-02 75 2 1 0.500 0.013 GO:0006941 BP 1 striated muscle contraction 1 P30626 40 3.77e-02 76 2 1 0.500 0.013 GO:0016247 MF 1 channel regulator activity 1 P30626 40 3.77e-02 76 2 1 0.500 0.013 GO:0070509 BP 1 calcium ion import 1 P30626 40 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 P30626 40 3.82e-02 77 2 1 0.500 0.013 GO:0019722 BP 1 calcium-mediated signaling 1 P30626 40 3.82e-02 77 2 1 0.500 0.013 GO:0002020 MF 1 protease binding 1 P30626 40 3.82e-02 77 2 1 0.500 0.013 GO:0030048 BP 1 actin filament-based movement 1 P30626 40 3.84e-02 247 2 1 0.500 0.004 TF:M05755_0 tf 1 Factor: ZNF718; motif: GTTAAGGARA; match class: 0 1 P30626 40 3.88e-02 72 2 1 0.500 0.014 REAC:418346 rea 1 Platelet homeostasis 1 P30626 40 3.96e-02 80 2 1 0.500 0.013 GO:0051651 BP 1 maintenance of location in cell 1 P30626 40 4.01e-02 81 2 1 0.500 0.012 GO:0051924 BP 1 regulation of calcium ion transport 1 P30626 40 4.04e-02 260 2 1 0.500 0.004 TF:M00251_0 tf 1 Factor: XBP-1; motif: NNGNTGACGTGKNNNWT; match class: 0 1 P34949 40 4.11e-02 264 2 1 0.500 0.004 TF:M01217_1 tf 1 Factor: NUR77; motif: NTGACCTTBN; match class: 1 1 P34949 40 4.11e-02 83 2 1 0.500 0.012 GO:0030017 CC 1 sarcomere 1 P30626 40 4.21e-02 85 2 1 0.500 0.012 GO:0090257 BP 1 regulation of muscle system process 1 P30626 40 4.21e-02 16 2 1 0.500 0.062 HP:0011473 hp 1 Villous atrophy 1 P34949 40 4.21e-02 16 2 1 0.500 0.062 HP:0011472 hp 1 Abnormality of small intestinal villus morphology 1 P34949 40 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 P30626,P34949 40 4.30e-02 80 2 1 0.500 0.013 REAC:2672351 rea 1 Stimuli-sensing channels 1 P30626 40 4.31e-02 2644 2 2 1.000 0.001 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 P30626,P34949 40 4.36e-02 88 2 1 0.500 0.011 GO:0061337 BP 1 cardiac conduction 1 P30626 40 4.36e-02 88 2 1 0.500 0.011 GO:2000021 BP 1 regulation of ion homeostasis 1 P30626 40 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 P34949 40 4.41e-02 89 2 1 0.500 0.011 GO:0032845 BP 1 negative regulation of homeostatic process 1 P30626 40 4.51e-02 290 2 1 0.500 0.003 TF:M04233_1 tf 1 Factor: FOXC1; motif: NGTMAATATTKACN; match class: 1 1 P30626 40 4.60e-02 296 2 1 0.500 0.003 TF:M07080_0 tf 1 Factor: C/EBPbeta; motif: KATTGCAYMAY; match class: 0 1 P30626 40 4.65e-02 94 2 1 0.500 0.011 GO:0030016 CC 1 myofibril 1 P30626 40 4.70e-02 95 2 1 0.500 0.011 GO:0044449 CC 1 contractile fiber part 1 P30626 40 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 P34949 40 4.80e-02 97 2 1 0.500 0.010 GO:0007204 BP 1 positive regulation of cytosolic calcium ion concentration 1 P30626 40 5.00e-02 101 2 1 0.500 0.010 GO:0043292 CC 1 contractile fiber 1 P30626 40 5.00e-02 19 2 1 0.500 0.053 HP:0012346 hp 1 Abnormal protein glycosylation 1 P34949 40 5.00e-02 407 2 2 1.000 0.005 MI:hsa-miR-921 mi 1 MI:hsa-miR-921 1 P30626,P34949 40 5.00e-02 19 2 1 0.500 0.053 HP:0012347 hp 1 Abnormal protein N-linked glycosylation 1 P34949 40 5.00e-02 101 2 1 0.500 0.010 GO:0032846 BP 1 positive regulation of homeostatic process 1 P30626 40 5.00e-02 2 2 1 0.500 0.500 CORUM:5371 cor 1 Grancalcin-sorcin complex 1 P30626 40 5.00e-02 7 2 1 0.500 0.143 OMIM:236750 omi 1 Hydrops Fetalis 1 P34949 40 5.00e-02 19 2 1 0.500 0.053 HP:0012345 hp 1 Abnormal glycosylation 1 P34949 40 5.00e-02 19 2 1 0.500 0.053 HP:0003160 hp 1 Abnormal isoelectric focusing of serum transferrin 1 P34949 40 5.00e-02 93 2 1 0.500 0.011 REAC:5576891 rea 1 Cardiac conduction 1 P30626 40 5.00e-02 32 2 1 0.500 0.031 KEGG:00051 keg 1 Fructose and mannose metabolism 1 P34949 41 1.44e-04 31 3 2 0.667 0.065 GO:0017069 MF 1 snRNA binding 1 Q8TEQ6,P83369 41 6.34e-04 522 3 3 1.000 0.006 GO:0016071 BP 1 mRNA metabolic process 1 Q8TEQ6,P47974,P83369 41 2.95e-03 1121 3 3 1.000 0.003 TF:M04146_1 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 1 1 Q8TEQ6,P47974,P83369 41 5.10e-03 469 3 2 0.667 0.004 MI:hsa-miR-513-3p mi 1 MI:hsa-miR-513-3p 1 Q8TEQ6,P83369 41 5.37e-03 3 3 1 0.333 0.333 GO:0071209 MF 1 U7 snRNA binding 1 P83369 41 6.14e-03 515 3 2 0.667 0.004 MI:hsa-miR-424 mi 1 MI:hsa-miR-424 1 Q8TEQ6,P83369 41 6.70e-03 2 3 1 0.333 0.500 CORUM:3298 cor 1 SMN complex (GEMIN2,5, SMN) 1 Q8TEQ6 41 7.16e-03 4 3 1 0.333 0.250 GO:1904627 BP 1 response to phorbol 13-acetate 12-myristate 1 P47974 41 7.16e-03 4 3 1 0.333 0.250 GO:1904628 BP 1 cellular response to phorbol 13-acetate 12-myristate 1 P47974 41 7.16e-03 4 3 1 0.333 0.250 GO:0097012 BP 1 response to granulocyte macrophage colony-stimulating factor 1 P47974 41 7.16e-03 4 3 1 0.333 0.250 GO:0097011 BP 1 cellular response to granulocyte macrophage colony-stimulating factor stimulus 1 P47974 41 7.99e-03 1563 3 3 1.000 0.002 TF:M04149_1 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 1 1 Q8TEQ6,P47974,P83369 41 8.25e-03 10 3 1 0.333 0.100 REAC:111367 rea 1 SLBP independent Processing of Histone Pre-mRNAs 1 P83369 41 8.35e-03 234 3 2 0.667 0.009 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 P47974,P83369 41 8.95e-03 5 3 1 0.333 0.200 GO:0060216 BP 1 definitive hemopoiesis 1 P47974 41 8.95e-03 5 3 1 0.333 0.200 GO:0006398 BP 1 mRNA 3'-end processing by stem-loop binding and cleavage 1 P83369 41 8.95e-03 5 3 1 0.333 0.200 GO:0071204 CC 1 histone pre-mRNA 3'end processing complex 1 P83369 41 9.00e-03 243 3 2 0.667 0.008 GO:1901987 BP 1 regulation of cell cycle phase transition 1 P47974,P83369 41 9.08e-03 11 3 1 0.333 0.091 REAC:77588 rea 1 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 1 P83369 41 1.01e-02 3 3 1 0.333 0.333 CORUM:3296 cor 1 SMN complex (GEMIN5,4,3), SMN-independent intermediate 1 Q8TEQ6 41 1.02e-02 10 3 1 0.333 0.100 TF:M00774_1 tf 1 Factor: NF-kappaB; motif: NNNNKGGRAANTCCCN; match class: 1 1 P47974 41 1.07e-02 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 Q8TEQ6,P47974,P83369 41 1.25e-02 7 3 1 0.333 0.143 GO:0005683 CC 1 U7 snRNP 1 P83369 41 1.34e-02 4 3 1 0.333 0.250 CORUM:3284 cor 1 SMN complex (GEMIN5,2,3,4, SMN) 1 Q8TEQ6 41 1.43e-02 8 3 1 0.333 0.125 GO:2000737 BP 1 negative regulation of stem cell differentiation 1 P47974 41 1.61e-02 9 3 1 0.333 0.111 GO:0061158 BP 1 3'-UTR-mediated mRNA destabilization 1 P47974 41 1.61e-02 9 3 1 0.333 0.111 GO:0071385 BP 1 cellular response to glucocorticoid stimulus 1 P47974 41 1.61e-02 9 3 1 0.333 0.111 GO:0035925 MF 1 mRNA 3'-UTR AU-rich region binding 1 P47974 41 1.73e-02 17 3 1 0.333 0.059 TF:M05932_0 tf 1 Factor: ZNF714; motif: NGGTGGGGACGM; match class: 0 1 P47974 41 1.77e-02 342 3 2 0.667 0.006 GO:0006397 BP 1 mRNA processing 1 Q8TEQ6,P83369 41 1.79e-02 10 3 1 0.333 0.100 GO:0071384 BP 1 cellular response to corticosteroid stimulus 1 P47974 41 1.97e-02 11 3 1 0.333 0.091 GO:0032797 CC 1 SMN complex 1 Q8TEQ6 41 1.97e-02 11 3 1 0.333 0.091 GO:0048103 BP 1 somatic stem cell division 1 P47974 41 2.00e-02 363 3 2 0.667 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 P47974,P83369 41 2.01e-02 6 3 1 0.333 0.167 CORUM:1752 cor 1 SMN complex 1 Q8TEQ6 41 2.06e-02 25 3 1 0.333 0.040 REAC:75067 rea 1 Processing of Capped Intronless Pre-mRNA 1 P83369 41 2.08e-02 2151 3 3 1.000 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 Q8TEQ6,P47974,P83369 41 2.15e-02 12 3 1 0.333 0.083 GO:1900153 BP 1 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 P47974 41 2.15e-02 12 3 1 0.333 0.083 GO:1900151 BP 1 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 P47974 41 2.15e-02 12 3 1 0.333 0.083 GO:1900087 BP 1 positive regulation of G1/S transition of mitotic cell cycle 1 P83369 41 2.32e-02 13 3 1 0.333 0.077 GO:0061157 BP 1 mRNA destabilization 1 P47974 41 2.32e-02 13 3 1 0.333 0.077 GO:0045577 BP 1 regulation of B cell differentiation 1 P47974 41 2.34e-02 7 3 1 0.333 0.143 CORUM:2757 cor 1 SMN complex, U7 snRNA specific 1 P83369 41 2.44e-02 402 3 2 0.667 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 P47974,P83369 41 2.49e-02 2282 3 3 1.000 0.001 TF:M04361_0 tf 1 Factor: HOXD12; motif: GTAATAAAA; match class: 0 1 Q8TEQ6,P47974,P83369 41 2.50e-02 14 3 1 0.333 0.071 GO:0050779 BP 1 RNA destabilization 1 P47974 41 2.53e-02 2296 3 3 1.000 0.001 TF:M07037_1 tf 1 Factor: C/EBPalpha; motif: NNNNNTTKCNNAAN; match class: 1 1 Q8TEQ6,P47974,P83369 41 2.55e-02 411 3 2 0.667 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P47974,P83369 41 2.64e-02 26 3 1 0.333 0.038 TF:M06341_0 tf 1 Factor: ZNF790; motif: NGGTGCAWATGA; match class: 0 1 P47974 41 2.68e-02 15 3 1 0.333 0.067 GO:0034719 CC 1 SMN-Sm protein complex 1 Q8TEQ6 41 2.68e-02 15 3 1 0.333 0.067 GO:0017145 BP 1 stem cell division 1 P47974 41 2.68e-02 15 3 1 0.333 0.067 GO:1902808 BP 1 positive regulation of cell cycle G1/S phase transition 1 P83369 41 2.73e-02 425 3 2 0.667 0.005 GO:0044770 BP 1 cell cycle phase transition 1 P47974,P83369 41 3.01e-02 9 3 1 0.333 0.111 CORUM:1751 cor 1 SMN complex 1 Q8TEQ6 41 3.04e-02 17 3 1 0.333 0.059 GO:0051384 BP 1 response to glucocorticoid 1 P47974 41 3.22e-02 18 3 1 0.333 0.056 GO:2000736 BP 1 regulation of stem cell differentiation 1 P47974 41 3.22e-02 18 3 1 0.333 0.056 GO:0031960 BP 1 response to corticosteroid 1 P47974 41 3.22e-02 18 3 1 0.333 0.056 GO:0071364 BP 1 cellular response to epidermal growth factor stimulus 1 P47974 41 3.40e-02 19 3 1 0.333 0.053 GO:0017091 MF 1 AU-rich element binding 1 P47974 41 3.57e-02 20 3 1 0.333 0.050 GO:0033077 BP 1 T cell differentiation in thymus 1 P47974 41 3.57e-02 20 3 1 0.333 0.050 GO:0061014 BP 1 positive regulation of mRNA catabolic process 1 P47974 41 3.57e-02 20 3 1 0.333 0.050 GO:0071594 BP 1 thymocyte aggregation 1 P47974 41 3.71e-02 2606 3 3 1.000 0.001 TF:M04149_0 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 0 1 Q8TEQ6,P47974,P83369 41 3.75e-02 21 3 1 0.333 0.048 GO:0005697 CC 1 telomerase holoenzyme complex 1 P83369 41 3.75e-02 21 3 1 0.333 0.048 GO:0070849 BP 1 response to epidermal growth factor 1 P47974 41 3.76e-02 37 3 1 0.333 0.027 TF:M00056_0 tf 1 Factor: myogenin; motif: CRSCTGTTBNNTTTGGCACGSNGCCARCH; match class: 0 1 P47974 41 3.93e-02 22 3 1 0.333 0.045 GO:0061013 BP 1 regulation of mRNA catabolic process 1 P47974 41 4.10e-02 50 3 1 0.333 0.020 REAC:194441 rea 1 Metabolism of non-coding RNA 1 Q8TEQ6 41 4.10e-02 50 3 1 0.333 0.020 REAC:191859 rea 1 snRNP Assembly 1 Q8TEQ6 41 4.11e-02 23 3 1 0.333 0.043 GO:0045599 BP 1 negative regulation of fat cell differentiation 1 P47974 41 4.16e-02 41 3 1 0.333 0.024 TF:M06857_0 tf 1 Factor: ZNF611; motif: KGGWCTGTAAAA; match class: 0 1 P47974 41 4.36e-02 2136 3 3 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 Q8TEQ6,P47974,P83369 41 4.37e-02 43 3 1 0.333 0.023 TF:M05966_0 tf 1 Factor: ZFP14; motif: NNRGGAATAAAA; match class: 0 1 Q8TEQ6 41 4.51e-02 2781 3 3 1.000 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 Q8TEQ6,P47974,P83369 41 4.68e-02 2816 3 3 1.000 0.001 TF:M07315_1 tf 1 Factor: C/EBPbeta; motif: NNTTKCNNMAN; match class: 1 1 Q8TEQ6,P47974,P83369 41 4.71e-02 3899 3 3 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q8TEQ6,P47974,P83369 41 4.72e-02 3902 3 3 1.000 0.001 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 Q8TEQ6,P47974,P83369 41 5.00e-02 15 3 1 0.333 0.067 CORUM:1143 cor 1 SMN complex 1 Q8TEQ6 41 5.00e-02 61 3 1 0.333 0.016 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 P83369 41 5.00e-02 15 3 1 0.333 0.067 CORUM:1745 cor 1 SMN complex 1 Q8TEQ6 41 5.00e-02 61 3 1 0.333 0.016 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 P83369 41 5.00e-02 28 3 1 0.333 0.036 GO:0008334 BP 1 histone mRNA metabolic process 1 P83369 42 3.04e-03 361 3 2 0.667 0.006 MI:hsa-miR-600 mi 1 MI:hsa-miR-600 1 Q9HCN8,B2RC85 42 4.07e-03 418 3 2 0.667 0.005 MI:hsa-miR-100 mi 1 MI:hsa-miR-100 1 Q9HCN8,B2RC85 42 1.31e-02 6 3 1 0.333 0.167 GO:0004169 MF 1 dolichyl-phosphate-mannose-protein mannosyltransferase activity 1 Q9HCN8 42 2.61e-02 12 3 1 0.333 0.083 GO:0071712 BP 1 ER-associated misfolded protein catabolic process 1 Q9HCN8 42 3.70e-02 17 3 1 0.333 0.059 GO:0071218 BP 1 cellular response to misfolded protein 1 Q9HCN8 42 3.91e-02 18 3 1 0.333 0.056 GO:0000030 MF 1 mannosyltransferase activity 1 Q9HCN8 42 4.35e-02 20 3 1 0.333 0.050 GO:0051788 BP 1 response to misfolded protein 1 Q9HCN8 42 5.00e-02 685 3 3 1.000 0.004 TF:M00665_0 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 0 1 Q9HCN8,B2RC85,Q6PCB0 42 5.00e-02 23 3 1 0.333 0.043 GO:0006515 BP 1 misfolded or incompletely synthesized protein catabolic process 1 Q9HCN8 43 3.54e-03 200 9 3 0.333 0.015 REAC:72312 rea 1 rRNA processing 1 P27635,P47914,Q9HC36 43 4.69e-03 14 9 2 0.222 0.143 CORUM:1230 cor 1 WINAC complex 1 Q9UIG0,Q02880 43 6.08e-03 1118 9 6 0.667 0.005 GO:0044822 MF 1 poly(A) RNA binding 1 O00411,Q9Y520,Q86XZ4,P27635,P47914,Q9HC36 43 7.21e-03 1 9 1 0.111 1.000 OMIM:300847 omi 1 AUTISM, SUSCEPTIBILITY TO, X-LINKED 5; AUTSX5 1 P27635 43 8.53e-03 3 9 1 0.111 0.333 REAC:163282 rea 1 Mitochondrial transcription initiation 1 O00411 43 1.14e-02 4 9 1 0.111 0.250 REAC:75944 rea 1 Transcription from mitochondrial promoters 1 O00411 43 1.14e-02 88 9 2 0.222 0.023 REAC:156902 rea 1 Peptide chain elongation 1 P27635,P47914 43 1.14e-02 88 9 2 0.222 0.023 REAC:192823 rea 1 Viral mRNA Translation 1 P27635,P47914 43 1.20e-02 639 9 3 0.333 0.005 MI:hsa-miR-548b-3p mi 1 MI:hsa-miR-548b-3p 1 Q02880,Q9Y520,Q9HC36 43 1.22e-02 91 9 2 0.222 0.022 REAC:2408557 rea 1 Selenocysteine synthesis 1 P27635,P47914 43 1.24e-02 92 9 2 0.222 0.022 REAC:156842 rea 1 Eukaryotic Translation Elongation 1 P27635,P47914 43 1.24e-02 92 9 2 0.222 0.022 REAC:72764 rea 1 Eukaryotic Translation Termination 1 P27635,P47914 43 1.30e-02 94 9 2 0.222 0.021 REAC:975956 rea 1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1 P27635,P47914 43 1.46e-02 100 9 2 0.222 0.020 REAC:72689 rea 1 Formation of a pool of free 40S subunits 1 P27635,P47914 43 1.68e-02 1336 9 6 0.667 0.004 GO:0003723 MF 1 RNA binding 1 O00411,Q9Y520,Q86XZ4,P27635,P47914,Q9HC36 43 1.76e-02 110 9 2 0.222 0.018 REAC:156827 rea 1 L13a-mediated translational silencing of Ceruloplasmin expression 1 P27635,P47914 43 1.79e-02 111 9 2 0.222 0.018 REAC:1799339 rea 1 SRP-dependent cotranslational protein targeting to membrane 1 P27635,P47914 43 1.79e-02 111 9 2 0.222 0.018 REAC:72706 rea 1 GTP hydrolysis and joining of the 60S ribosomal subunit 1 P27635,P47914 43 1.86e-02 113 9 2 0.222 0.018 REAC:975957 rea 1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1 P27635,P47914 43 1.86e-02 113 9 2 0.222 0.018 REAC:927802 rea 1 Nonsense-Mediated Decay (NMD) 1 P27635,P47914 43 1.92e-02 115 9 2 0.222 0.017 REAC:2408522 rea 1 Selenoamino acid metabolism 1 P27635,P47914 43 2.02e-02 118 9 2 0.222 0.017 REAC:72737 rea 1 Cap-dependent Translation Initiation 1 P27635,P47914 43 2.02e-02 118 9 2 0.222 0.017 REAC:72613 rea 1 Eukaryotic Translation Initiation 1 P27635,P47914 43 2.32e-02 7 9 1 0.111 0.143 HP:0004764 hp 1 Myxomatous mitral valve degeneration 1 Q9UIG0 43 2.32e-02 7 9 1 0.111 0.143 HP:0010794 hp 1 Impaired visuospatial constructive cognition 1 Q9UIG0 43 2.32e-02 7 9 1 0.111 0.143 HP:0005145 hp 1 Coronary artery stenosis 1 Q9UIG0 43 2.51e-02 132 9 2 0.222 0.015 REAC:168273 rea 1 Influenza Viral RNA Transcription and Replication 1 P27635,P47914 43 2.53e-02 4080 9 8 0.889 0.002 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 Q9UIG0,O00411,Q9Y520,Q86XZ4,P27635,P47914,Q9H6W3,Q9HC36 43 2.65e-02 8 9 1 0.111 0.125 HP:0012450 hp 1 Chronic constipation 1 Q9UIG0 43 2.65e-02 8 9 1 0.111 0.125 HP:0001136 hp 1 Retinal arteriolar tortuosity 1 Q9UIG0 43 2.65e-02 8 9 1 0.111 0.125 HP:0004381 hp 1 Supravalvular aortic stenosis 1 Q9UIG0 43 2.80e-02 140 9 2 0.222 0.014 REAC:168255 rea 1 Influenza Life Cycle 1 P27635,P47914 43 2.98e-02 9 9 1 0.111 0.111 HP:0002608 hp 1 Celiac disease 1 Q9UIG0 43 2.98e-02 9 9 1 0.111 0.111 HP:0008770 hp 1 Obsessive-compulsive trait 1 Q9UIG0 43 2.98e-02 9 9 1 0.111 0.111 HP:0004428 hp 1 Elfin facies 1 Q9UIG0 43 3.03e-02 2 9 1 0.111 0.500 CORUM:236 cor 1 WICH complex 1 Q9UIG0 43 3.24e-02 151 9 2 0.222 0.013 REAC:168254 rea 1 Influenza Infection 1 P27635,P47914 43 3.30e-02 10 9 1 0.111 0.100 HP:0100785 hp 1 Insomnia 1 Q9UIG0 43 3.30e-02 10 9 1 0.111 0.100 HP:0007720 hp 1 Flat cornea 1 Q9UIG0 43 3.30e-02 10 9 1 0.111 0.100 HP:0001605 hp 1 Vocal cord paralysis 1 Q9UIG0 43 3.41e-02 155 9 2 0.222 0.013 REAC:72766 rea 1 Translation 1 P27635,P47914 43 3.63e-02 11 9 1 0.111 0.091 HP:0100817 hp 1 Renovascular hypertension 1 Q9UIG0 43 3.63e-02 11 9 1 0.111 0.091 HP:0010780 hp 1 Hyperacusis 1 Q9UIG0 43 3.95e-02 12 9 1 0.111 0.083 HP:0007099 hp 1 Arnold-Chiari type I malformation 1 Q9UIG0 43 3.95e-02 12 9 1 0.111 0.083 HP:0002623 hp 1 Overriding aorta 1 Q9UIG0 43 4.22e-02 419 9 2 0.222 0.005 MI:hsa-miR-192 mi 1 MI:hsa-miR-192 1 Q86XZ4,Q9HC36 43 4.28e-02 13 9 1 0.111 0.077 HP:0000075 hp 1 Renal duplication 1 Q9UIG0 43 4.28e-02 13 9 1 0.111 0.077 HP:0002183 hp 1 Phonophobia 1 Q9UIG0 43 4.60e-02 14 9 1 0.111 0.071 HP:0004969 hp 1 Peripheral pulmonary artery stenosis 1 Q9UIG0 43 4.81e-02 450 9 2 0.222 0.004 MI:hsa-miR-215 mi 1 MI:hsa-miR-215 1 Q86XZ4,Q9HC36 43 4.93e-02 456 9 2 0.222 0.004 MI:hsa-miR-542-3p mi 1 MI:hsa-miR-542-3p 1 Q02880,Q86XZ4 43 5.00e-02 2 9 1 0.111 0.500 TF:M06290_1 tf 1 Factor: Cos52; motif: NGGTCCDCCWGW; match class: 1 1 P47914 43 5.00e-02 7 9 1 0.111 0.143 OMIM:209850 omi 1 Autism 1 P27635 43 5.00e-02 129 9 2 0.222 0.016 KEGG:03010 keg 1 Ribosome 1 P27635,P47914 43 5.00e-02 1485 9 5 0.556 0.003 REAC:74160 rea 1 Gene Expression 1 Q9UIG0,O00411,P27635,P47914,Q9HC36 43 5.00e-02 41 9 2 0.222 0.049 GO:0009295 CC 1 nucleoid 1 Q02880,O00411 43 5.00e-02 1220 9 6 0.667 0.005 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 Q02880,O00411,Q86XZ4,P27635,P47914,Q9HC36 43 5.00e-02 46 9 2 0.222 0.043 CORUM:308 cor 1 60S ribosomal subunit, cytoplasmic 1 P27635,P47914 44 3.17e-17 16 7 6 0.857 0.375 GO:0005942 CC 1 phosphatidylinositol 3-kinase complex 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.35e-15 30 7 6 0.857 0.200 GO:0016303 MF 1 1-phosphatidylinositol-3-kinase activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.24e-15 17 7 6 0.857 0.353 REAC:912631 rea 1 Regulation of signaling by CBL 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.41e-15 35 7 6 0.857 0.171 GO:0052742 MF 1 phosphatidylinositol kinase activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.70e-14 46 7 6 0.857 0.130 GO:0035004 MF 1 phosphatidylinositol 3-kinase activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.24e-13 35 7 6 0.857 0.171 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.07e-13 37 7 6 0.857 0.162 REAC:114604 rea 1 GPVI-mediated activation cascade 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.21e-13 38 7 6 0.857 0.158 REAC:397795 rea 1 G-protein beta:gamma signalling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.68e-13 31 7 6 0.857 0.194 KEGG:04960 keg 1 Aldosterone-regulated sodium reabsorption 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.15e-12 33 7 6 0.857 0.182 KEGG:04973 keg 1 Carbohydrate digestion and absorption 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.18e-12 80 7 6 0.857 0.075 GO:0006661 BP 1 phosphatidylinositol biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.84e-12 44 7 6 0.857 0.136 REAC:2219530 rea 1 Constitutive Signaling by Aberrant PI3K in Cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.84e-12 44 7 6 0.857 0.136 REAC:1660499 rea 1 Synthesis of PIPs at the plasma membrane 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.87e-12 38 7 6 0.857 0.158 KEGG:04923 keg 1 Regulation of lipolysis in adipocytes 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.20e-12 94 7 6 0.857 0.064 GO:0014065 BP 1 phosphatidylinositol 3-kinase signaling 1 P42338,O00459,P42336,Q9P242,P27986,O00329 44 5.29e-12 102 7 6 0.857 0.059 GO:0046488 BP 1 phosphatidylinositol metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.46e-12 42 7 6 0.857 0.143 KEGG:04930 keg 1 Type II diabetes mellitus 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.29e-11 118 7 6 0.857 0.051 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 P42338,O00459,P42336,Q9P242,P27986,O00329 44 1.31e-11 39 7 5 0.714 0.128 GO:0046934 MF 1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1 P42338,O00459,P42336,P27986,O00329 44 1.36e-11 119 7 6 0.857 0.050 GO:0048017 BP 1 inositol lipid-mediated signaling 1 P42338,O00459,P42336,Q9P242,P27986,O00329 44 1.45e-11 49 7 6 0.857 0.122 KEGG:05213 keg 1 Endometrial cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.93e-11 42 7 5 0.714 0.119 GO:0052813 MF 1 phosphatidylinositol bisphosphate kinase activity 1 P42338,O00459,P42336,P27986,O00329 44 1.95e-11 64 7 6 0.857 0.094 REAC:6811558 rea 1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.11e-11 52 7 6 0.857 0.115 KEGG:05223 keg 1 Non-small cell lung cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.11e-11 52 7 6 0.857 0.115 KEGG:05221 keg 1 Acute myeloid leukemia 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.60e-11 67 7 6 0.857 0.090 REAC:2219528 rea 1 PI3K/AKT Signaling in Cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.68e-11 54 7 6 0.857 0.111 KEGG:04370 keg 1 VEGF signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.68e-11 54 7 6 0.857 0.111 KEGG:05218 keg 1 Melanoma 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.68e-11 54 7 6 0.857 0.111 KEGG:04664 keg 1 Fc epsilon RI signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.85e-11 68 7 6 0.857 0.088 REAC:1483255 rea 1 PI Metabolism 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.37e-11 56 7 6 0.857 0.107 KEGG:04917 keg 1 Prolactin signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.73e-11 71 7 6 0.857 0.085 REAC:199418 rea 1 Negative regulation of the PI3K/AKT network 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.77e-11 57 7 6 0.857 0.105 KEGG:04213 keg 1 Longevity regulating pathway - multiple species 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.77e-11 57 7 6 0.857 0.105 KEGG:05214 keg 1 Glioma 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.20e-11 58 7 6 0.857 0.103 KEGG:05210 keg 1 Colorectal cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.36e-11 144 7 6 0.857 0.042 GO:0046474 BP 1 glycerophospholipid biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.67e-11 59 7 6 0.857 0.102 KEGG:05211 keg 1 Renal cell carcinoma 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.67e-11 59 7 6 0.857 0.102 KEGG:04662 keg 1 B cell receptor signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.76e-11 61 7 6 0.857 0.098 KEGG:05212 keg 1 Pancreatic cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.68e-11 158 7 6 0.857 0.038 GO:0008654 BP 1 phospholipid biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.77e-11 64 7 6 0.857 0.094 KEGG:05230 keg 1 Central carbon metabolism in cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 9.28e-11 163 7 6 0.857 0.037 GO:0045017 BP 1 glycerolipid biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.24e-10 69 7 6 0.857 0.087 KEGG:05220 keg 1 Chronic myeloid leukemia 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.36e-10 70 7 6 0.857 0.086 KEGG:04620 keg 1 Toll-like receptor signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.48e-10 176 7 6 0.857 0.034 GO:0019898 CC 1 extrinsic component of membrane 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.48e-10 71 7 6 0.857 0.085 KEGG:01524 keg 1 Platinum drug resistance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.62e-10 72 7 6 0.857 0.083 KEGG:04750 keg 1 Inflammatory mediator regulation of TRP channels 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.76e-10 73 7 6 0.857 0.082 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.76e-10 73 7 6 0.857 0.082 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.26e-10 76 7 6 0.857 0.079 KEGG:04670 keg 1 Leukocyte transendothelial migration 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.26e-10 76 7 6 0.857 0.079 KEGG:05146 keg 1 Amoebiasis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.43e-10 191 7 6 0.857 0.031 GO:0006650 BP 1 glycerophospholipid metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.45e-10 77 7 6 0.857 0.078 KEGG:05215 keg 1 Prostate cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.66e-10 78 7 6 0.857 0.077 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.87e-10 79 7 6 0.857 0.076 KEGG:04668 keg 1 TNF signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:5654720 rea 1 PI-3K cascade:FGFR4 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:1250342 rea 1 PI3K events in ERBB4 signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:1257604 rea 1 PIP3 activates AKT signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:5654710 rea 1 PI-3K cascade:FGFR3 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:5654695 rea 1 PI-3K cascade:FGFR2 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-10 100 7 6 0.857 0.060 REAC:5654689 rea 1 PI-3K cascade:FGFR1 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.11e-10 80 7 6 0.857 0.075 KEGG:04012 keg 1 ErbB signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.11e-10 80 7 6 0.857 0.075 KEGG:04915 keg 1 Estrogen signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.35e-10 81 7 6 0.857 0.074 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.49e-10 102 7 6 0.857 0.059 REAC:198203 rea 1 PI3K/AKT activation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.62e-10 82 7 6 0.857 0.073 KEGG:04630 keg 1 Jak-STAT signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.71e-10 103 7 6 0.857 0.058 REAC:180292 rea 1 GAB1 signalosome 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.90e-10 83 7 6 0.857 0.072 KEGG:04211 keg 1 Longevity regulating pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.17e-10 105 7 6 0.857 0.057 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.20e-10 84 7 6 0.857 0.071 KEGG:04650 keg 1 Natural killer cell mediated cytotoxicity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.20e-10 84 7 6 0.857 0.071 KEGG:05222 keg 1 Small cell lung cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.20e-10 84 7 6 0.857 0.071 KEGG:04660 keg 1 T cell receptor signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.52e-10 85 7 6 0.857 0.071 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.86e-10 86 7 6 0.857 0.070 KEGG:05231 keg 1 Choline metabolism in cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.86e-10 86 7 6 0.857 0.070 KEGG:04933 keg 1 AGE-RAGE signaling pathway in diabetic complications 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.86e-10 86 7 6 0.857 0.070 KEGG:04066 keg 1 HIF-1 signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.12e-10 216 7 6 0.857 0.028 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.21e-10 87 7 6 0.857 0.069 KEGG:01522 keg 1 Endocrine resistance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.59e-10 88 7 6 0.857 0.068 KEGG:04725 keg 1 Cholinergic synapse 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.78e-10 81 7 5 0.714 0.062 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 P42338,O00459,P42336,P27986,O00329 44 6.00e-10 89 7 6 0.857 0.067 KEGG:04070 keg 1 Phosphatidylinositol signaling system 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.43e-10 90 7 6 0.857 0.067 KEGG:04380 keg 1 Osteoclast differentiation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.36e-10 92 7 6 0.857 0.065 KEGG:05160 keg 1 Hepatitis C 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 8.96e-10 95 7 6 0.857 0.063 KEGG:05145 keg 1 Toxoplasmosis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 9.45e-10 239 7 6 0.857 0.025 GO:0046486 BP 1 glycerolipid metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 9.56e-10 96 7 6 0.857 0.062 KEGG:04931 keg 1 Insulin resistance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 9.69e-10 240 7 6 0.857 0.025 GO:0006644 BP 1 phospholipid metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.01e-09 4 7 3 0.429 0.750 GO:0035014 MF 1 phosphatidylinositol 3-kinase regulator activity 1 O00459,Q92569,P27986 44 1.01e-09 4 7 3 0.429 0.750 GO:0046935 MF 1 1-phosphatidylinositol-3-kinase regulator activity 1 O00459,Q92569,P27986 44 1.08e-09 98 7 6 0.857 0.061 KEGG:05162 keg 1 Measles 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.47e-09 103 7 6 0.857 0.058 KEGG:04611 keg 1 Platelet activation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.56e-09 104 7 6 0.857 0.058 KEGG:04722 keg 1 Neurotrophin signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.56e-09 104 7 6 0.857 0.058 KEGG:04071 keg 1 Sphingolipid signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.66e-09 105 7 6 0.857 0.057 KEGG:04919 keg 1 Thyroid hormone signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.86e-09 107 7 6 0.857 0.056 KEGG:04152 keg 1 AMPK signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.97e-09 108 7 6 0.857 0.056 KEGG:04550 keg 1 Signaling pathways regulating pluripotency of stem cells 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.33e-09 111 7 6 0.857 0.054 KEGG:04068 keg 1 FoxO signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.46e-09 112 7 6 0.857 0.054 KEGG:05224 keg 1 Breast cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.53e-09 5 7 3 0.429 0.600 GO:2001275 BP 1 positive regulation of glucose import in response to insulin stimulus 1 O00459,Q92569,P27986 44 3.21e-09 117 7 6 0.857 0.051 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.38e-09 118 7 6 0.857 0.051 KEGG:04210 keg 1 Apoptosis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.75e-09 120 7 6 0.857 0.050 KEGG:04062 keg 1 Chemokine signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.95e-09 121 7 6 0.857 0.050 KEGG:04910 keg 1 Insulin signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.13e-09 16 7 4 0.571 0.250 REAC:210993 rea 1 Tie2 Signaling 1 P42338,O00459,P42336,P27986 44 4.15e-09 122 7 6 0.857 0.049 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.58e-09 124 7 6 0.857 0.048 KEGG:05161 keg 1 Hepatitis B 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.81e-09 125 7 6 0.857 0.048 KEGG:04932 keg 1 Non-alcoholic fatty liver disease (NAFLD) 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.05e-09 124 7 5 0.714 0.040 GO:0050852 BP 1 T cell receptor signaling pathway 1 P42338,O00459,P42336,P27986,O00329 44 5.05e-09 6 7 3 0.429 0.500 GO:0044381 BP 1 glucose import in response to insulin stimulus 1 O00459,Q92569,P27986 44 5.05e-09 6 7 3 0.429 0.500 GO:2001273 BP 1 regulation of glucose import in response to insulin stimulus 1 O00459,Q92569,P27986 44 5.40e-09 17 7 4 0.571 0.235 REAC:389357 rea 1 CD28 dependent PI3K/Akt signaling 1 O00459,Q92569,P42336,P27986 44 5.83e-09 129 7 6 0.857 0.047 KEGG:05164 keg 1 Influenza A 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.11e-09 130 7 6 0.857 0.046 KEGG:04921 keg 1 Oxytocin signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.58e-09 165 7 6 0.857 0.036 REAC:1483257 rea 1 Phospholipid metabolism 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.12e-09 334 7 6 0.857 0.018 GO:0090407 BP 1 organophosphate biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.34e-09 168 7 6 0.857 0.036 REAC:1168372 rea 1 Downstream signaling events of B Cell Receptor (BCR) 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.35e-09 134 7 6 0.857 0.045 KEGG:04150 keg 1 mTOR signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.69e-09 135 7 6 0.857 0.044 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 8.84e-09 7 7 3 0.429 0.429 GO:0035005 MF 1 1-phosphatidylinositol-4-phosphate 3-kinase activity 1 P42338,P42336,O00329 44 8.84e-09 7 7 3 0.429 0.429 GO:1900078 BP 1 positive regulation of cellular response to insulin stimulus 1 O00459,Q92569,P27986 44 1.04e-08 143 7 5 0.714 0.035 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 P42338,O00459,P42336,P27986,O00329 44 1.24e-08 146 7 6 0.857 0.041 KEGG:04024 keg 1 cAMP signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.25e-08 367 7 6 0.857 0.016 GO:0008610 BP 1 lipid biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.36e-08 21 7 4 0.571 0.190 REAC:2029485 rea 1 Role of phospholipids in phagocytosis 1 P42338,O00459,P42336,P27986 44 1.40e-08 149 7 6 0.857 0.040 KEGG:04360 keg 1 Axon guidance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.41e-08 187 7 6 0.857 0.032 REAC:983705 rea 1 Signaling by the B Cell Receptor (BCR) 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.66e-08 22 7 4 0.571 0.182 REAC:373753 rea 1 Nephrin interactions 1 P42338,O00459,P42336,P27986 44 1.78e-08 155 7 6 0.857 0.039 KEGG:04015 keg 1 Rap1 signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.20e-08 166 7 5 0.714 0.030 GO:0050900 BP 1 leukocyte migration 1 P42338,O00459,P42336,P27986,O00329 44 2.31e-08 203 7 6 0.857 0.030 REAC:912526 rea 1 Interleukin receptor SHC signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.33e-08 162 7 6 0.857 0.037 KEGG:05203 keg 1 Viral carcinogenesis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.70e-08 166 7 6 0.857 0.036 KEGG:04014 keg 1 Ras signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.76e-08 209 7 6 0.857 0.029 REAC:451927 rea 1 Interleukin-2 signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.09e-08 213 7 6 0.857 0.028 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.47e-08 173 7 6 0.857 0.035 KEGG:05205 keg 1 Proteoglycans in cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.56e-08 218 7 6 0.857 0.028 REAC:512988 rea 1 Interleukin-3, 5 and GM-CSF signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.72e-08 175 7 6 0.857 0.034 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.27e-08 179 7 6 0.857 0.034 KEGG:04510 keg 1 Focal adhesion 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.41e-08 180 7 6 0.857 0.033 KEGG:05169 keg 1 Epstein-Barr virus infection 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.63e-08 28 7 4 0.571 0.143 REAC:389356 rea 1 CD28 co-stimulation 1 O00459,Q92569,P42336,P27986 44 5.55e-08 12 7 3 0.429 0.250 GO:0046854 BP 1 phosphatidylinositol phosphorylation 1 O00459,P42336,P27986 44 7.05e-08 68 7 4 0.571 0.059 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 P42338,O00459,P42336,P27986 44 7.05e-08 68 7 4 0.571 0.059 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 P42338,O00459,P42336,P27986 44 7.05e-08 68 7 4 0.571 0.059 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 P42338,O00459,P42336,P27986 44 7.93e-08 70 7 4 0.571 0.057 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 P42338,O00459,P42336,P27986 44 8.27e-08 216 7 5 0.714 0.023 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 P42338,O00459,P42336,P27986,O00329 44 8.40e-08 71 7 4 0.571 0.056 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 P42338,O00459,P42336,P27986 44 9.18e-08 14 7 3 0.429 0.214 GO:0016307 MF 1 phosphatidylinositol phosphate kinase activity 1 P42338,P42336,O00329 44 1.15e-07 15 7 3 0.429 0.200 GO:0046326 BP 1 positive regulation of glucose import 1 O00459,Q92569,P27986 44 1.26e-07 235 7 5 0.714 0.021 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 P42338,O00459,P42336,P27986,O00329 44 1.30e-07 79 7 4 0.571 0.051 GO:0008286 BP 1 insulin receptor signaling pathway 1 O00459,Q92569,P42336,P27986 44 1.32e-07 271 7 6 0.857 0.022 REAC:1433557 rea 1 Signaling by SCF-KIT 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.35e-07 272 7 6 0.857 0.022 REAC:1236394 rea 1 Signaling by ERBB4 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.40e-07 218 7 6 0.857 0.028 KEGG:05166 keg 1 HTLV-I infection 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.61e-07 280 7 6 0.857 0.021 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.61e-07 280 7 6 0.857 0.021 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.61e-07 280 7 6 0.857 0.021 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.64e-07 281 7 6 0.857 0.021 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.71e-07 17 7 3 0.429 0.176 GO:0010828 BP 1 positive regulation of glucose transport 1 O00459,Q92569,P27986 44 1.72e-07 283 7 6 0.857 0.021 REAC:5654743 rea 1 Signaling by FGFR4 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.72e-07 283 7 6 0.857 0.021 REAC:5654741 rea 1 Signaling by FGFR3 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.79e-07 285 7 6 0.857 0.021 REAC:5654736 rea 1 Signaling by FGFR1 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.87e-07 287 7 6 0.857 0.021 REAC:449147 rea 1 Signaling by Interleukins 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.91e-07 578 7 6 0.857 0.010 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.99e-07 290 7 6 0.857 0.021 REAC:2424491 rea 1 DAP12 signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.07e-07 292 7 6 0.857 0.021 REAC:186763 rea 1 Downstream signal transduction 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.16e-07 294 7 6 0.857 0.020 REAC:2172127 rea 1 DAP12 interactions 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.64e-07 304 7 6 0.857 0.020 REAC:177929 rea 1 Signaling by EGFR 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.69e-07 305 7 6 0.857 0.020 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.87e-07 20 7 3 0.429 0.150 GO:0046834 BP 1 lipid phosphorylation 1 O00459,P42336,P27986 44 2.91e-07 309 7 6 0.857 0.019 REAC:5663202 rea 1 Diseases of signal transduction 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.91e-07 309 7 6 0.857 0.019 REAC:5654738 rea 1 Signaling by FGFR2 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.02e-07 624 7 6 0.857 0.010 GO:1990234 CC 1 transferase complex 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.03e-07 311 7 6 0.857 0.019 REAC:190236 rea 1 Signaling by FGFR 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.08e-07 312 7 6 0.857 0.019 REAC:186797 rea 1 Signaling by PDGF 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.20e-07 630 7 6 0.857 0.010 GO:0016301 MF 1 kinase activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.29e-07 633 7 6 0.857 0.009 GO:0044255 BP 1 cellular lipid metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.35e-07 21 7 3 0.429 0.143 GO:0043551 BP 1 regulation of phosphatidylinositol 3-kinase activity 1 O00459,Q92569,P27986 44 3.73e-07 322 7 6 0.857 0.019 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.78e-07 257 7 6 0.857 0.023 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.45e-07 23 7 3 0.429 0.130 GO:0046324 BP 1 regulation of glucose import 1 O00459,Q92569,P27986 44 4.50e-07 303 7 5 0.714 0.017 GO:0002757 BP 1 immune response-activating signal transduction 1 P42338,O00459,P42336,P27986,O00329 44 4.77e-07 109 7 4 0.571 0.037 GO:0032869 BP 1 cellular response to insulin stimulus 1 O00459,Q92569,P42336,P27986 44 4.79e-07 674 7 6 0.857 0.009 GO:0019637 BP 1 organophosphate metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.32e-07 112 7 4 0.571 0.036 GO:0038095 BP 1 Fc-epsilon receptor signaling pathway 1 P42338,O00459,P42336,P27986 44 5.35e-07 342 7 6 0.857 0.018 REAC:388396 rea 1 GPCR downstream signaling 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.63e-07 317 7 5 0.714 0.016 GO:0002252 BP 1 immune effector process 1 P42338,O00459,P42336,P27986,O00329 44 5.72e-07 114 7 4 0.571 0.035 GO:0032868 BP 1 response to insulin 1 O00459,Q92569,P42336,P27986 44 5.83e-07 2 7 2 0.286 1.000 GO:0005943 CC 1 phosphatidylinositol 3-kinase complex, class IA 1 P42336,P27986 44 6.09e-07 322 7 5 0.714 0.016 GO:0002764 BP 1 immune response-regulating signaling pathway 1 P42338,O00459,P42336,P27986,O00329 44 6.57e-07 53 7 4 0.571 0.075 REAC:388841 rea 1 Costimulation by the CD28 family 1 O00459,Q92569,P42336,P27986 44 7.35e-07 27 7 3 0.429 0.111 GO:0043550 BP 1 regulation of lipid kinase activity 1 O00459,Q92569,P27986 44 7.64e-07 337 7 5 0.714 0.015 GO:0002253 BP 1 activation of immune response 1 P42338,O00459,P42336,P27986,O00329 44 9.02e-07 12 7 3 0.429 0.250 REAC:1266695 rea 1 Interleukin-7 signaling 1 O00459,Q92569,P27986 44 9.17e-07 29 7 3 0.429 0.103 GO:0046323 BP 1 glucose import 1 O00459,Q92569,P27986 44 9.42e-07 755 7 6 0.857 0.008 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.02e-06 30 7 3 0.429 0.100 GO:1900076 BP 1 regulation of cellular response to insulin stimulus 1 O00459,Q92569,P27986 44 1.02e-06 765 7 6 0.857 0.008 GO:0006629 BP 1 lipid metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.13e-06 31 7 3 0.429 0.097 GO:1903725 BP 1 regulation of phospholipid metabolic process 1 O00459,Q92569,P27986 44 1.25e-06 394 7 6 0.857 0.015 REAC:166520 rea 1 Signalling by NGF 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.38e-06 142 7 4 0.571 0.028 GO:0006909 BP 1 phagocytosis 1 P42338,O00459,P42336,P27986 44 1.51e-06 65 7 4 0.571 0.062 REAC:109704 rea 1 PI3K Cascade 1 P42338,O00459,P42336,P27986 44 1.52e-06 387 7 5 0.714 0.013 GO:0050778 BP 1 positive regulation of immune response 1 P42338,O00459,P42336,P27986,O00329 44 1.55e-06 325 7 6 0.857 0.018 KEGG:05200 keg 1 Pathways in cancer 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.75e-06 3 7 2 0.286 0.667 GO:0097651 CC 1 phosphatidylinositol 3-kinase complex, class I 1 P42336,P27986 44 1.92e-06 851 7 6 0.857 0.007 GO:0044711 BP 1 single-organism biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.04e-06 70 7 4 0.571 0.057 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 P42338,O00459,P42336,P27986 44 2.42e-06 73 7 4 0.571 0.055 REAC:416482 rea 1 G alpha (12/13) signalling events 1 O00459,Q92569,P42336,P27986 44 2.52e-06 165 7 4 0.571 0.024 GO:0038093 BP 1 Fc receptor signaling pathway 1 P42338,O00459,P42336,P27986 44 2.56e-06 444 7 6 0.857 0.014 REAC:109582 rea 1 Hemostasis 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.59e-06 166 7 4 0.571 0.024 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 O00459,Q92569,P42336,P27986 44 2.62e-06 432 7 5 0.714 0.012 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 P42338,O00459,Q92569,P42336,P27986 44 2.63e-06 446 7 6 0.857 0.013 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.98e-06 172 7 4 0.571 0.023 GO:1901653 BP 1 cellular response to peptide 1 O00459,Q92569,P42336,P27986 44 3.12e-06 459 7 6 0.857 0.013 REAC:422475 rea 1 Axon guidance 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.65e-06 181 7 4 0.571 0.022 GO:0043434 BP 1 response to peptide hormone 1 O00459,Q92569,P42336,P27986 44 3.70e-06 81 7 4 0.571 0.049 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 P42338,O00459,P42336,P27986 44 4.44e-06 190 7 4 0.571 0.021 GO:1901652 BP 1 response to peptide 1 O00459,Q92569,P42336,P27986 44 5.17e-06 88 7 4 0.571 0.045 REAC:416476 rea 1 G alpha (q) signalling events 1 O00459,Q92569,P42336,P27986 44 5.36e-06 499 7 5 0.714 0.010 GO:0002684 BP 1 positive regulation of immune system process 1 P42338,O00459,P42336,P27986,O00329 44 5.41e-06 89 7 4 0.571 0.045 REAC:202424 rea 1 Downstream TCR signaling 1 P42338,O00459,P42336,P27986 44 5.47e-06 501 7 5 0.714 0.010 GO:0050776 BP 1 regulation of immune response 1 P42338,O00459,P42336,P27986,O00329 44 6.08e-06 1033 7 6 0.857 0.006 GO:1902494 CC 1 catalytic complex 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.74e-06 94 7 4 0.571 0.043 REAC:1500931 rea 1 Cell-Cell communication 1 P42338,O00459,P42336,P27986 44 7.69e-06 58 7 3 0.429 0.052 GO:0010827 BP 1 regulation of glucose transport 1 O00459,Q92569,P27986 44 8.18e-06 1086 7 6 0.857 0.006 GO:0048584 BP 1 positive regulation of response to stimulus 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.09e-05 106 7 4 0.571 0.038 REAC:202403 rea 1 TCR signaling 1 P42338,O00459,P42336,P27986 44 1.22e-05 577 7 6 0.857 0.010 REAC:372790 rea 1 Signaling by GPCR 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.26e-05 593 7 5 0.714 0.008 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 P42338,O00459,Q92569,P42336,P27986 44 1.55e-05 260 7 4 0.571 0.015 GO:0071417 BP 1 cellular response to organonitrogen compound 1 O00459,Q92569,P42336,P27986 44 1.63e-05 606 7 6 0.857 0.010 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.77e-05 614 7 6 0.857 0.010 REAC:1280218 rea 1 Adaptive Immune System 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.83e-05 640 7 5 0.714 0.008 GO:0016477 BP 1 cell migration 1 P42338,O00459,P42336,P27986,O00329 44 1.88e-05 2 7 2 0.286 1.000 CORUM:3133 cor 1 Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) 1 P42336,P27986 44 1.89e-05 78 7 3 0.429 0.038 GO:0008645 BP 1 hexose transport 1 O00459,Q92569,P27986 44 1.89e-05 78 7 3 0.429 0.038 GO:0015758 BP 1 glucose transport 1 O00459,Q92569,P27986 44 1.96e-05 79 7 3 0.429 0.038 GO:0015749 BP 1 monosaccharide transport 1 O00459,Q92569,P27986 44 2.03e-05 1266 7 6 0.857 0.005 GO:0016310 BP 1 phosphorylation 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.27e-05 83 7 3 0.429 0.036 GO:0008643 BP 1 carbohydrate transport 1 O00459,Q92569,P27986 44 2.65e-05 690 7 5 0.714 0.007 GO:0002682 BP 1 regulation of immune system process 1 P42338,O00459,P42336,P27986,O00329 44 2.99e-05 307 7 4 0.571 0.013 GO:0010243 BP 1 response to organonitrogen compound 1 O00459,Q92569,P42336,P27986 44 3.07e-05 711 7 5 0.714 0.007 GO:0051674 BP 1 localization of cell 1 P42338,O00459,P42336,P27986,O00329 44 3.07e-05 711 7 5 0.714 0.007 GO:0048870 BP 1 cell motility 1 P42338,O00459,P42336,P27986,O00329 44 3.14e-05 311 7 4 0.571 0.013 GO:0032870 BP 1 cellular response to hormone stimulus 1 O00459,Q92569,P42336,P27986 44 3.31e-05 315 7 4 0.571 0.013 GO:1901699 BP 1 cellular response to nitrogen compound 1 O00459,Q92569,P42336,P27986 44 3.71e-05 739 7 5 0.714 0.007 GO:0006955 BP 1 immune response 1 P42338,O00459,P42336,P27986,O00329 44 3.92e-05 1416 7 6 0.857 0.004 GO:0007166 BP 1 cell surface receptor signaling pathway 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.17e-05 334 7 4 0.571 0.012 GO:0016337 BP 1 single organismal cell-cell adhesion 1 P42338,P42336,P27986,O00329 44 4.47e-05 718 7 6 0.857 0.008 REAC:1266738 rea 1 Developmental Biology 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.55e-05 720 7 6 0.857 0.008 REAC:1643685 rea 1 Disease 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.02e-05 108 7 3 0.429 0.028 GO:0030168 BP 1 platelet activation 1 P42338,P42336,P27986 44 5.12e-05 352 7 4 0.571 0.011 GO:0009725 BP 1 response to hormone 1 O00459,Q92569,P42336,P27986 44 5.24e-05 354 7 4 0.571 0.011 GO:0006897 BP 1 endocytosis 1 P42338,O00459,P42336,P27986 44 5.47e-05 1498 7 6 0.857 0.004 GO:0044765 BP 1 single-organism transport 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 5.95e-05 814 7 5 0.714 0.006 GO:0040011 BP 1 locomotion 1 P42338,O00459,P42336,P27986,O00329 44 6.24e-05 370 7 4 0.571 0.011 GO:0098602 BP 1 single organism cell adhesion 1 P42338,P42336,P27986,O00329 44 6.26e-05 1533 7 6 0.857 0.004 GO:0035556 BP 1 intracellular signal transduction 1 P42338,O00459,P42336,Q9P242,P27986,O00329 44 6.78e-05 378 7 4 0.571 0.011 GO:1901698 BP 1 response to nitrogen compound 1 O00459,Q92569,P42336,P27986 44 7.06e-05 121 7 3 0.429 0.025 GO:0030258 BP 1 lipid modification 1 O00459,P42336,P27986 44 7.29e-05 385 7 4 0.571 0.010 GO:0001775 BP 1 cell activation 1 P42338,P42336,P27986,O00329 44 7.60e-05 389 7 4 0.571 0.010 GO:0098609 BP 1 cell-cell adhesion 1 P42338,P42336,P27986,O00329 44 7.60e-05 124 7 3 0.429 0.024 GO:0019207 MF 1 kinase regulator activity 1 O00459,Q92569,P27986 44 9.72e-05 1652 7 6 0.857 0.004 GO:1902578 BP 1 single-organism localization 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.21e-04 1715 7 6 0.857 0.003 GO:0016740 MF 1 transferase activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.22e-04 439 7 4 0.571 0.009 GO:0043549 BP 1 regulation of kinase activity 1 P42338,O00459,Q92569,P27986 44 1.26e-04 147 7 3 0.429 0.020 GO:0019216 BP 1 regulation of lipid metabolic process 1 O00459,Q92569,P27986 44 1.28e-04 444 7 4 0.571 0.009 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 O00459,Q92569,P42336,P27986 44 1.32e-04 958 7 5 0.714 0.005 GO:0016192 BP 1 vesicle-mediated transport 1 P42338,O00459,P42336,P27986,O00329 44 1.49e-04 3004 7 7 1.000 0.002 GO:0007165 BP 1 signal transduction 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 1.75e-04 1016 7 5 0.714 0.005 GO:0006928 BP 1 movement of cell or subcellular component 1 P42338,O00459,P42336,P27986,O00329 44 1.85e-04 1027 7 5 0.714 0.005 GO:1902531 BP 1 regulation of intracellular signal transduction 1 P42338,O00459,P42336,P27986,O00329 44 1.89e-04 1851 7 6 0.857 0.003 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.02e-04 172 7 3 0.429 0.017 GO:0042110 BP 1 T cell activation 1 P42336,P27986,O00329 44 2.02e-04 172 7 3 0.429 0.017 GO:0070489 BP 1 T cell aggregation 1 P42336,P27986,O00329 44 2.05e-04 173 7 3 0.429 0.017 GO:0071593 BP 1 lymphocyte aggregation 1 P42336,P27986,O00329 44 2.08e-04 1882 7 6 0.857 0.003 GO:0042221 BP 1 response to chemical 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.17e-04 938 7 6 0.857 0.006 REAC:168249 rea 1 Innate Immune System 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.19e-04 28 7 2 0.286 0.071 GO:0042993 BP 1 positive regulation of transcription factor import into nucleus 1 O00459,P27986 44 2.23e-04 178 7 3 0.429 0.017 GO:0070486 BP 1 leukocyte aggregation 1 P42336,P27986,O00329 44 2.36e-04 1923 7 6 0.857 0.003 GO:0006793 BP 1 phosphorus metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.49e-04 66 7 3 0.429 0.045 KEGG:00562 keg 1 Inositol phosphate metabolism 1 P42338,P42336,O00329 44 2.66e-04 3262 7 7 1.000 0.002 GO:0007154 BP 1 cell communication 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.67e-04 10 7 2 0.286 0.200 REAC:8853334 rea 1 Signaling by FGFR3 fusions in cancer 1 P42336,P27986 44 2.69e-04 31 7 2 0.286 0.065 GO:0038128 BP 1 ERBB2 signaling pathway 1 P42336,P27986 44 2.69e-04 3268 7 7 1.000 0.002 GO:0044700 BP 1 single organism signaling 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.73e-04 3274 7 7 1.000 0.002 GO:0023052 BP 1 signaling 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.84e-04 240 7 4 0.571 0.017 REAC:112399 rea 1 IRS-mediated signalling 1 P42338,O00459,P42336,P27986 44 2.89e-04 241 7 4 0.571 0.017 REAC:2428924 rea 1 IGF1R signaling cascade 1 P42338,O00459,P42336,P27986 44 2.89e-04 241 7 4 0.571 0.017 REAC:2428928 rea 1 IRS-related events triggered by IGF1R 1 P42338,O00459,P42336,P27986 44 2.93e-04 242 7 4 0.571 0.017 REAC:2404192 rea 1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1 P42338,O00459,P42336,P27986 44 2.93e-04 242 7 4 0.571 0.017 REAC:74751 rea 1 Insulin receptor signalling cascade 1 P42338,O00459,P42336,P27986 44 3.06e-04 198 7 3 0.429 0.015 GO:0007159 BP 1 leukocyte cell-cell adhesion 1 P42336,P27986,O00329 44 3.26e-04 11 7 2 0.286 0.182 REAC:5655291 rea 1 Signaling by FGFR4 in disease 1 P42336,P27986 44 3.40e-04 1165 7 5 0.714 0.004 GO:0002376 BP 1 immune system process 1 P42338,O00459,P42336,P27986,O00329 44 3.55e-04 577 7 4 0.571 0.007 GO:0051338 BP 1 regulation of transferase activity 1 P42338,O00459,Q92569,P27986 44 3.64e-04 36 7 2 0.286 0.056 GO:1990782 MF 1 protein tyrosine kinase binding 1 O00459,P27986 44 3.64e-04 36 7 2 0.286 0.056 GO:0030971 MF 1 receptor tyrosine kinase binding 1 O00459,P27986 44 3.77e-04 586 7 4 0.571 0.007 GO:1901700 BP 1 response to oxygen-containing compound 1 O00459,Q92569,P42336,P27986 44 3.91e-04 12 7 2 0.286 0.167 REAC:1963642 rea 1 PI3K events in ERBB2 signaling 1 P42336,P27986 44 3.96e-04 2101 7 6 0.857 0.003 GO:0048583 BP 1 regulation of response to stimulus 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.07e-04 263 7 4 0.571 0.015 REAC:74752 rea 1 Signaling by Insulin receptor 1 P42338,O00459,P42336,P27986 44 4.24e-04 221 7 3 0.429 0.014 GO:0007596 BP 1 blood coagulation 1 P42338,P42336,P27986 44 4.27e-04 39 7 2 0.286 0.051 GO:0031294 BP 1 lymphocyte costimulation 1 P42336,P27986 44 4.27e-04 39 7 2 0.286 0.051 GO:0031295 BP 1 T cell costimulation 1 P42336,P27986 44 4.35e-04 223 7 3 0.429 0.013 GO:0007599 BP 1 hemostasis 1 P42338,P42336,P27986 44 4.41e-04 224 7 3 0.429 0.013 GO:0050817 BP 1 coagulation 1 P42338,P42336,P27986 44 4.65e-04 272 7 4 0.571 0.015 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 P42338,O00459,P42336,P27986 44 5.06e-04 278 7 4 0.571 0.014 REAC:194138 rea 1 Signaling by VEGF 1 P42338,O00459,P42336,P27986 44 5.20e-04 43 7 2 0.286 0.047 GO:0001678 BP 1 cellular glucose homeostasis 1 O00459,P27986 44 5.27e-04 238 7 3 0.429 0.013 GO:0046649 BP 1 lymphocyte activation 1 P42336,P27986,O00329 44 5.38e-04 14 7 2 0.286 0.143 REAC:5637810 rea 1 Constitutive Signaling by EGFRvIII 1 P42336,P27986 44 5.38e-04 14 7 2 0.286 0.143 REAC:5655332 rea 1 Signaling by FGFR3 in disease 1 P42336,P27986 44 5.38e-04 14 7 2 0.286 0.143 REAC:5637812 rea 1 Signaling by EGFRvIII in Cancer 1 P42336,P27986 44 5.38e-04 14 7 2 0.286 0.143 REAC:8853338 rea 1 Signaling by FGFR3 point mutants in cancer 1 P42336,P27986 44 5.40e-04 643 7 4 0.571 0.006 GO:0071495 BP 1 cellular response to endogenous stimulus 1 O00459,Q92569,P42336,P27986 44 5.74e-04 287 7 4 0.571 0.014 REAC:881907 rea 1 Gastrin-CREB signalling pathway via PKC and MAPK 1 O00459,Q92569,P42336,P27986 44 6.63e-04 678 7 4 0.571 0.006 GO:0007155 BP 1 cell adhesion 1 P42338,P42336,P27986,O00329 44 6.66e-04 1340 7 5 0.714 0.004 GO:0032879 BP 1 regulation of localization 1 P42338,O00459,Q92569,P27986,O00329 44 6.86e-04 684 7 4 0.571 0.006 GO:0022610 BP 1 biological adhesion 1 P42338,P42336,P27986,O00329 44 7.13e-04 3755 7 7 1.000 0.002 GO:0051716 BP 1 cellular response to stimulus 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 7.33e-04 51 7 2 0.286 0.039 GO:0042307 BP 1 positive regulation of protein import into nucleus 1 O00459,P27986 44 7.48e-04 268 7 3 0.429 0.011 GO:0050878 BP 1 regulation of body fluid levels 1 P42338,P42336,P27986 44 7.62e-04 52 7 2 0.286 0.038 GO:1904591 BP 1 positive regulation of protein import 1 O00459,P27986 44 7.62e-04 52 7 2 0.286 0.038 GO:0042990 BP 1 regulation of transcription factor import into nucleus 1 O00459,P27986 44 8.01e-04 712 7 4 0.571 0.006 GO:0009719 BP 1 response to endogenous stimulus 1 O00459,Q92569,P42336,P27986 44 8.03e-04 17 7 2 0.286 0.118 REAC:1236382 rea 1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1 P42336,P27986 44 8.03e-04 17 7 2 0.286 0.118 REAC:5637815 rea 1 Signaling by Ligand-Responsive EGFR Variants in Cancer 1 P42336,P27986 44 8.03e-04 17 7 2 0.286 0.118 REAC:1643713 rea 1 Signaling by EGFR in Cancer 1 P42336,P27986 44 8.53e-04 55 7 2 0.286 0.036 GO:0042991 BP 1 transcription factor import into nucleus 1 O00459,P27986 44 8.83e-04 2412 7 6 0.857 0.002 GO:0044425 CC 1 membrane part 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 8.88e-04 1423 7 5 0.714 0.004 GO:0070887 BP 1 cellular response to chemical stimulus 1 O00459,Q92569,P42336,P27986,O00329 44 8.96e-04 285 7 3 0.429 0.011 GO:0045321 BP 1 leukocyte activation 1 P42336,P27986,O00329 44 9.03e-04 18 7 2 0.286 0.111 REAC:1839117 rea 1 Signaling by cytosolic FGFR1 fusion mutants 1 P42336,P27986 44 1.03e-03 760 7 4 0.571 0.005 GO:0042325 BP 1 regulation of phosphorylation 1 P42338,O00459,Q92569,P27986 44 1.03e-03 299 7 3 0.429 0.010 GO:0030155 BP 1 regulation of cell adhesion 1 P42338,P42336,P27986 44 1.04e-03 300 7 3 0.429 0.010 GO:0042060 BP 1 wound healing 1 P42338,P42336,P27986 44 1.19e-03 65 7 2 0.286 0.031 GO:0046824 BP 1 positive regulation of nucleocytoplasmic transport 1 O00459,P27986 44 1.25e-03 2560 7 6 0.857 0.002 GO:0044710 BP 1 single-organism metabolic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.42e-03 71 7 2 0.286 0.028 GO:0019903 MF 1 protein phosphatase binding 1 O00459,P27986 44 1.43e-03 334 7 3 0.429 0.009 GO:0009611 BP 1 response to wounding 1 P42338,P42336,P27986 44 1.43e-03 1573 7 5 0.714 0.003 GO:0009966 BP 1 regulation of signal transduction 1 P42338,O00459,P42336,P27986,O00329 44 1.46e-03 72 7 2 0.286 0.028 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 O00459,P27986 44 1.50e-03 2644 7 6 0.857 0.002 GO:0006810 BP 1 transport 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.72e-03 2707 7 6 0.857 0.002 GO:0005829 CC 1 cytosol 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.77e-03 25 7 2 0.286 0.080 REAC:1839124 rea 1 FGFR1 mutant receptor activation 1 P42336,P27986 44 1.80e-03 80 7 2 0.286 0.025 GO:0033500 BP 1 carbohydrate homeostasis 1 O00459,P27986 44 1.80e-03 80 7 2 0.286 0.025 GO:0042593 BP 1 glucose homeostasis 1 O00459,P27986 44 1.84e-03 885 7 4 0.571 0.005 GO:0019220 BP 1 regulation of phosphate metabolic process 1 P42338,O00459,Q92569,P27986 44 1.87e-03 2748 7 6 0.857 0.002 GO:0051234 BP 1 establishment of localization 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.91e-03 26 7 2 0.286 0.077 REAC:983695 rea 1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1 P27986,O00329 44 1.93e-03 2761 7 6 0.857 0.002 GO:0048522 BP 1 positive regulation of cellular process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.94e-03 897 7 4 0.571 0.004 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 P42338,O00459,Q92569,P27986 44 2.02e-03 1691 7 5 0.714 0.003 GO:0010646 BP 1 regulation of cell communication 1 P42338,O00459,P42336,P27986,O00329 44 2.02e-03 4356 7 7 1.000 0.002 GO:0050896 BP 1 response to stimulus 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.15e-03 922 7 4 0.571 0.004 GO:0010628 BP 1 positive regulation of gene expression 1 P42338,O00459,P27986,O00329 44 2.23e-03 1728 7 5 0.714 0.003 GO:0023051 BP 1 regulation of signaling 1 P42338,O00459,P42336,P27986,O00329 44 2.24e-03 2 7 1 0.143 0.500 GO:0002551 BP 1 mast cell chemotaxis 1 O00329 44 2.24e-03 2 7 1 0.143 0.500 GO:0035747 BP 1 natural killer cell chemotaxis 1 O00329 44 2.24e-03 2 7 1 0.143 0.500 GO:0060374 BP 1 mast cell differentiation 1 O00329 44 2.24e-03 2 7 1 0.143 0.500 GO:0097531 BP 1 mast cell migration 1 O00329 44 2.28e-03 936 7 4 0.571 0.004 GO:0051049 BP 1 regulation of transport 1 P42338,O00459,Q92569,P27986 44 2.43e-03 93 7 2 0.286 0.022 GO:0050870 BP 1 positive regulation of T cell activation 1 P42336,P27986 44 2.48e-03 94 7 2 0.286 0.021 GO:0042306 BP 1 regulation of protein import into nucleus 1 O00459,P27986 44 2.53e-03 95 7 2 0.286 0.021 GO:1903039 BP 1 positive regulation of leukocyte cell-cell adhesion 1 P42336,P27986 44 2.59e-03 96 7 2 0.286 0.021 GO:1904589 BP 1 regulation of protein import 1 O00459,P27986 44 2.64e-03 97 7 2 0.286 0.021 GO:0007173 BP 1 epidermal growth factor receptor signaling pathway 1 P42336,P27986 44 2.85e-03 1457 7 6 0.857 0.004 REAC:168256 rea 1 Immune System 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 2.86e-03 101 7 2 0.286 0.020 GO:0019902 MF 1 phosphatase binding 1 O00459,P27986 44 2.91e-03 32 7 2 0.286 0.062 REAC:5655302 rea 1 Signaling by FGFR1 in disease 1 P42336,P27986 44 3.20e-03 161 7 2 0.286 0.012 TF:M05322_0 tf 1 Factor: T-box; motif: TTCACACCTR; match class: 0 1 P42338,P27986 44 3.29e-03 34 7 2 0.286 0.059 REAC:5655253 rea 1 Signaling by FGFR2 in disease 1 P42336,P27986 44 3.30e-03 3033 7 6 0.857 0.002 GO:0048518 BP 1 positive regulation of biological process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.33e-03 109 7 2 0.286 0.018 GO:0022409 BP 1 positive regulation of cell-cell adhesion 1 P42336,P27986 44 3.36e-03 3 7 1 0.143 0.333 GO:0038028 BP 1 insulin receptor signaling pathway via phosphatidylinositol 3-kinase 1 P42336 44 3.64e-03 114 7 2 0.286 0.018 GO:0038127 BP 1 ERBB signaling pathway 1 P42336,P27986 44 3.70e-03 115 7 2 0.286 0.017 GO:0051251 BP 1 positive regulation of lymphocyte activation 1 P42336,P27986 44 3.80e-03 1071 7 4 0.571 0.004 GO:0050790 BP 1 regulation of catalytic activity 1 P42338,O00459,Q92569,P27986 44 3.90e-03 1 7 1 0.143 1.000 OMIM:615214 omi 1 AGAMMAGLOBULINEMIA 7, AUTOSOMAL RECESSIVE; AGM7;;AGAMMAGLOBULINEMIA, AUTOSOMAL RECESSIVE, DUE TO PIK3R1 DEFECT 1 P27986 44 3.90e-03 1 7 1 0.143 1.000 OMIM:612918 omi 1 CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, AND EPIDERMALNEVI;;CLOVE SYNDROME;;CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, EPIDERMALNEVI, AND SKELETAL/SPINAL ABNORMALITIES;;CLOVES SYNDROME 1 P42336 44 3.90e-03 1 7 1 0.143 1.000 OMIM:615513 omi 1 IMMUNODEFICIENCY 14; IMD14;;ACTIVATED PI3K-DELTA SYNDROME; APDS;;p110-DELTA-ACTIVATING MUTATION CAUSING SENESCENT T CELLS, LYMPHADENOPATHY,AND IMMUNODEFICIENCY; PASLI 1 O00329 44 3.90e-03 1 7 1 0.143 1.000 OMIM:603387 omi 1 MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 1;MPPH1;;MEGALENCEPHALY, POLYMICROGYRIA, MEGA CORPUS CALLOSUM SYNDROME; MPPH;;MEG-PMG-MEGACC SYNDROME;;MEGALENCEPHALY, MEGA CORPUS CALLOSUM, AND COMPLETE LACK OF MOTOR DEVELOPMENT 1 O00459 44 3.90e-03 1 7 1 0.143 1.000 OMIM:615108 omi 1 COWDEN SYNDROME 5; CWS5 1 P42336 44 3.90e-03 1 7 1 0.143 1.000 OMIM:182000 omi 1 KERATOSIS, SEBORRHEIC 1 P42336 44 3.90e-03 1 7 1 0.143 1.000 OMIM:602501 omi 1 MEGALENCEPHALY-CAPILLARY MALFORMATION-POLYMICROGYRIA SYNDROME; MCAP;;MACROCEPHALY-CAPILLARY MALFORMATION; MCM;;MEGALENCEPHALY-CAPILLARY MALFORMATION SYNDROME;;MACROCEPHALY-CUTIS MARMORATA TELANGIECTATICA CONGENITA; MCMTC;;MEGALENCEPHALY-CUTIS MARMORATA TELANGIECTATICA CONGENITA 1 P42336 44 3.90e-03 1 7 1 0.143 1.000 OMIM:269880 omi 1 SHORT SYNDROME;;SHORT STATURE, HYPEREXTENSIBILITY, HERNIA, OCULAR DEPRESSION, RIEGERANOMALY, AND TEETHING DELAY;;LIPODYSTROPHY, PARTIAL, WITH RIEGER ANOMALY AND SHORT STATURE 1 P27986 44 3.90e-03 1 7 1 0.143 1.000 OMIM:616005 omi 1 IMMUNODEFICIENCY 36; IMD36 1 P27986 44 3.96e-03 119 7 2 0.286 0.017 GO:1900180 BP 1 regulation of protein localization to nucleus 1 O00459,P27986 44 3.96e-03 119 7 2 0.286 0.017 GO:0050863 BP 1 regulation of T cell activation 1 P42336,P27986 44 4.16e-03 122 7 2 0.286 0.016 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 O00459,P27986 44 4.16e-03 483 7 3 0.429 0.006 GO:0051050 BP 1 positive regulation of transport 1 O00459,Q92569,P27986 44 4.22e-03 123 7 2 0.286 0.016 GO:1903037 BP 1 regulation of leukocyte cell-cell adhesion 1 P42336,P27986 44 4.48e-03 4 7 1 0.143 0.250 GO:0035754 BP 1 B cell chemotaxis 1 O00329 44 4.48e-03 4 7 1 0.143 0.250 GO:0072672 BP 1 neutrophil extravasation 1 O00329 44 4.48e-03 4 7 1 0.143 0.250 GO:0001779 BP 1 natural killer cell differentiation 1 O00329 44 4.48e-03 4 7 1 0.143 0.250 GO:0043125 MF 1 ErbB-3 class receptor binding 1 P27986 44 4.48e-03 4 7 1 0.143 0.250 GO:0043559 MF 1 insulin binding 1 P27986 44 4.48e-03 1575 7 6 0.857 0.004 REAC:162582 rea 1 Signal Transduction 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 4.50e-03 127 7 2 0.286 0.016 GO:0002696 BP 1 positive regulation of leukocyte activation 1 P42336,P27986 44 4.86e-03 132 7 2 0.286 0.015 GO:0050867 BP 1 positive regulation of cell activation 1 P42336,P27986 44 4.94e-03 9 7 1 0.143 0.111 TF:M00532_0 tf 1 Factor: RP58; motif: NNAACATCTGGA; match class: 0 1 P27986 44 5.08e-03 1157 7 4 0.571 0.003 GO:0071310 BP 1 cellular response to organic substance 1 O00459,Q92569,P42336,P27986 44 5.22e-03 2071 7 5 0.714 0.002 GO:0006950 BP 1 response to stress 1 P42338,O00459,P42336,P27986,O00329 44 5.27e-03 43 7 2 0.286 0.047 REAC:1227986 rea 1 Signaling by ERBB2 1 P42336,P27986 44 5.49e-03 10 7 1 0.143 0.100 TF:M06406_0 tf 1 Factor: ZNF534; motif: NTGTCAAGCTGC; match class: 0 1 O00329 44 5.60e-03 5 7 1 0.143 0.200 GO:0005168 MF 1 neurotrophin TRKA receptor binding 1 P27986 44 5.60e-03 5 7 1 0.143 0.200 GO:0005167 MF 1 neurotrophin TRK receptor binding 1 P27986 44 5.60e-03 5 7 1 0.143 0.200 GO:0002679 BP 1 respiratory burst involved in defense response 1 O00329 44 6.10e-03 756 7 3 0.429 0.004 TF:M00425_1 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 1 1 P42338,P42336,O00329 44 6.33e-03 3401 7 6 0.857 0.002 GO:0051179 BP 1 localization 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.36e-03 2724 7 5 0.714 0.002 TF:M04134_0 tf 1 Factor: TBX2; motif: NAGGTGTGAAN; match class: 0 1 P42338,Q92569,Q9P242,P27986,O00329 44 6.48e-03 3415 7 6 0.857 0.002 GO:0032991 CC 1 macromolecular complex 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 6.49e-03 153 7 2 0.286 0.013 GO:0051249 BP 1 regulation of lymphocyte activation 1 P42336,P27986 44 6.72e-03 6 7 1 0.143 0.167 GO:0043560 MF 1 insulin receptor substrate binding 1 P27986 44 6.72e-03 6 7 1 0.143 0.167 GO:0005068 MF 1 transmembrane receptor protein tyrosine kinase adaptor activity 1 P27986 44 6.82e-03 574 7 3 0.429 0.005 GO:1902582 BP 1 single-organism intracellular transport 1 O00459,P27986,O00329 44 7.09e-03 582 7 3 0.429 0.005 GO:0030234 MF 1 enzyme regulator activity 1 O00459,Q92569,P27986 44 7.40e-03 1718 7 6 0.857 0.003 REAC:1430728 rea 1 Metabolism 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.43e-03 3499 7 6 0.857 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 7.61e-03 166 7 2 0.286 0.012 GO:0090316 BP 1 positive regulation of intracellular protein transport 1 O00459,P27986 44 7.70e-03 167 7 2 0.286 0.012 GO:0044744 BP 1 protein targeting to nucleus 1 O00459,P27986 44 7.70e-03 167 7 2 0.286 0.012 GO:1902593 BP 1 single-organism nuclear import 1 O00459,P27986 44 7.70e-03 167 7 2 0.286 0.012 GO:0006606 BP 1 protein import into nucleus 1 O00459,P27986 44 7.70e-03 167 7 2 0.286 0.012 GO:0022407 BP 1 regulation of cell-cell adhesion 1 P42336,P27986 44 7.80e-03 168 7 2 0.286 0.012 GO:0045785 BP 1 positive regulation of cell adhesion 1 P42336,P27986 44 7.83e-03 7 7 1 0.143 0.143 GO:0010818 BP 1 T cell chemotaxis 1 O00329 44 8.31e-03 54 7 2 0.286 0.037 REAC:1226099 rea 1 Signaling by FGFR in disease 1 P42336,P27986 44 8.31e-03 3569 7 6 0.857 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 8.77e-03 16 7 1 0.143 0.062 TF:M06012_0 tf 1 Factor: ZNF586; motif: ATGGCGTGMTG; match class: 0 1 Q92569 44 8.82e-03 179 7 2 0.286 0.011 GO:0002694 BP 1 regulation of leukocyte activation 1 P42336,P27986 44 8.95e-03 8 7 1 0.143 0.125 GO:0005165 MF 1 neurotrophin receptor binding 1 P27986 44 9.01e-03 3620 7 6 0.857 0.002 GO:0009058 BP 1 biosynthetic process 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 9.21e-03 183 7 2 0.286 0.011 GO:1903533 BP 1 regulation of protein targeting 1 O00459,P27986 44 9.31e-03 184 7 2 0.286 0.011 GO:0051170 BP 1 nuclear import 1 O00459,P27986 44 9.81e-03 189 7 2 0.286 0.011 GO:0032388 BP 1 positive regulation of intracellular transport 1 O00459,P27986 44 9.99e-03 1388 7 4 0.571 0.003 GO:0065009 BP 1 regulation of molecular function 1 P42338,O00459,Q92569,P27986 44 1.00e-02 289 7 2 0.286 0.007 TF:M06379_0 tf 1 Factor: ZNF770; motif: NWGGGGCGAG; match class: 0 1 Q92569,P27986 44 1.01e-02 9 7 1 0.143 0.111 GO:0048009 BP 1 insulin-like growth factor receptor signaling pathway 1 P27986 44 1.01e-02 9 7 1 0.143 0.111 GO:0005159 MF 1 insulin-like growth factor receptor binding 1 P27986 44 1.01e-02 1394 7 4 0.571 0.003 GO:0010033 BP 1 response to organic substance 1 O00459,Q92569,P42336,P27986 44 1.07e-02 198 7 2 0.286 0.010 GO:0050865 BP 1 regulation of cell activation 1 P42336,P27986 44 1.08e-02 5533 7 7 1.000 0.001 GO:0050794 BP 1 regulation of cellular process 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 1.12e-02 10 7 1 0.143 0.100 GO:1900103 BP 1 positive regulation of endoplasmic reticulum unfolded protein response 1 P27986 44 1.17e-02 3 7 1 0.143 0.333 OMIM:601495 omi 1 Autosomal Agammaglobulinemia 1 P27986 44 1.17e-02 207 7 2 0.286 0.010 GO:0010506 BP 1 regulation of autophagy 1 P42338,O00459 44 1.18e-02 208 7 2 0.286 0.010 GO:0017038 BP 1 protein import 1 O00459,P27986 44 1.19e-02 209 7 2 0.286 0.010 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 O00459,P27986 44 1.23e-02 11 7 1 0.143 0.091 GO:0017046 MF 1 peptide hormone binding 1 P27986 44 1.23e-02 322 7 2 0.286 0.006 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 P42338,P27986 44 1.30e-02 6847 7 7 1.000 0.001 TF:M00098_1 tf 1 Factor: Pax-2; motif: NNNNGTCANGNRTKANNNN; match class: 1 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 1.33e-02 221 7 2 0.286 0.009 GO:0034504 BP 1 protein localization to nucleus 1 O00459,P27986 44 1.34e-02 12 7 1 0.143 0.083 GO:0048247 BP 1 lymphocyte chemotaxis 1 O00329 44 1.45e-02 13 7 1 0.143 0.077 GO:2000811 BP 1 negative regulation of anoikis 1 P42336 44 1.45e-02 13 7 1 0.143 0.077 GO:0043548 MF 1 phosphatidylinositol 3-kinase binding 1 P27986 44 1.45e-02 13 7 1 0.143 0.077 GO:0005158 MF 1 insulin receptor binding 1 P27986 44 1.45e-02 13 7 1 0.143 0.077 GO:2000369 BP 1 regulation of clathrin-dependent endocytosis 1 P42338 44 1.48e-02 1040 7 3 0.429 0.003 TF:M05882_0 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 0 1 Q92569,Q9P242,P27986 44 1.52e-02 237 7 2 0.286 0.008 GO:0033157 BP 1 regulation of intracellular protein transport 1 O00459,P27986 44 1.54e-02 362 7 2 0.286 0.006 TF:M03847_1 tf 1 Factor: Sox15; motif: ACAAWGGG; match class: 1 1 Q92569,O00329 44 1.55e-02 4 7 1 0.143 0.250 OMIM:162900 omi 1 NEVUS, EPIDERMAL;;NEVUS, KERATINOCYTIC, NONEPIDERMOLYTICNEVUS SEBACEOUS, INCLUDED;;NEVUS, WOOLLY HAIR, INCLUDED 1 P42336 44 1.56e-02 14 7 1 0.143 0.071 GO:0045730 BP 1 respiratory burst 1 O00329 44 1.57e-02 771 7 3 0.429 0.004 GO:1902580 BP 1 single-organism cellular localization 1 O00459,P27986,O00329 44 1.57e-02 5839 7 7 1.000 0.001 GO:0050789 BP 1 regulation of biological process 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 1.61e-02 244 7 2 0.286 0.008 GO:0051222 BP 1 positive regulation of protein transport 1 O00459,P27986 44 1.62e-02 4019 7 6 0.857 0.001 GO:0003824 MF 1 catalytic activity 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 1.64e-02 246 7 2 0.286 0.008 GO:0042330 BP 1 taxis 1 P42338,O00329 44 1.64e-02 246 7 2 0.286 0.008 GO:0006935 BP 1 chemotaxis 1 P42338,O00329 44 1.64e-02 246 7 2 0.286 0.008 GO:1903829 BP 1 positive regulation of cellular protein localization 1 O00459,P27986 44 1.64e-02 30 7 1 0.143 0.033 TF:M06185_0 tf 1 Factor: ZNF92; motif: NGTTRTGGAGGM; match class: 0 1 P42338 44 1.65e-02 2083 7 4 0.571 0.002 TF:M01871_0 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 0 1 P42336,Q9P242,P27986,O00329 44 1.68e-02 15 7 1 0.143 0.067 GO:0033120 BP 1 positive regulation of RNA splicing 1 P27986 44 1.68e-02 4986 7 6 0.857 0.001 TF:M02108_0 tf 1 Factor: Nkx2.5; motif: NNCACTTGNRN; match class: 0 1 P42338,O00459,Q92569,Q9P242,P27986,O00329 44 1.69e-02 2096 7 4 0.571 0.002 TF:M00053_0 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 0 1 P42338,Q92569,P27986,O00329 44 1.78e-02 2706 7 5 0.714 0.002 GO:0044707 BP 1 single-multicellular organism process 1 P42338,P42336,Q9P242,P27986,O00329 44 1.79e-02 16 7 1 0.143 0.062 GO:0072678 BP 1 T cell migration 1 O00329 44 1.79e-02 16 7 1 0.143 0.062 GO:1900101 BP 1 regulation of endoplasmic reticulum unfolded protein response 1 P27986 44 1.79e-02 16 7 1 0.143 0.062 GO:0071378 BP 1 cellular response to growth hormone stimulus 1 P27986 44 1.79e-02 16 7 1 0.143 0.062 GO:0060396 BP 1 growth hormone receptor signaling pathway 1 P27986 44 1.80e-02 33 7 1 0.143 0.030 TF:M03940_0 tf 1 Factor: ZNF75A; motif: GCTTTTCCCACA; match class: 0 1 Q92569 44 1.82e-02 1121 7 3 0.429 0.003 TF:M04146_1 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 1 1 P42338,O00459,O00329 44 1.85e-02 1128 7 3 0.429 0.003 TF:M04115_0 tf 1 Factor: EOMES; motif: NAGGTGTGAANNN; match class: 0 1 P42338,P27986,O00329 44 1.85e-02 1644 7 4 0.571 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 P42338,O00459,P27986,O00329 44 1.89e-02 3470 7 5 0.714 0.001 TF:M01082_1 tf 1 Factor: BRCA1:USF2; motif: KTNNGTTG; match class: 1 1 P42338,P42336,Q9P242,P27986,O00329 44 1.91e-02 828 7 3 0.429 0.004 GO:0098772 MF 1 molecular function regulator 1 O00459,Q92569,P27986 44 1.94e-02 5 7 1 0.143 0.200 OMIM:613659 omi 1 GASTRIC CANCERGASTRIC CANCER, INTESTINAL, INCLUDED 1 P42336 44 1.95e-02 12 7 2 0.286 0.167 HP:0001355 hp 1 Megalencephaly 1 O00459,P42336 44 2.01e-02 18 7 1 0.143 0.056 GO:2000209 BP 1 regulation of anoikis 1 P42336 44 2.01e-02 18 7 1 0.143 0.056 GO:0060416 BP 1 response to growth hormone 1 P27986 44 2.15e-02 3 7 1 0.143 0.333 CORUM:2577 cor 1 Sam68-p85 P13K-IRS-1-IR signaling complex 1 P27986 44 2.15e-02 3 7 1 0.143 0.333 CORUM:2470 cor 1 p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex 1 P27986 44 2.15e-02 3 7 1 0.143 0.333 CORUM:2574 cor 1 CD19-Vav-PI 3-kinase (p85 subunit) complex 1 P27986 44 2.15e-02 3 7 1 0.143 0.333 CORUM:2944 cor 1 Notch1-p56lck-PI3K complex 1 P27986 44 2.17e-02 1196 7 3 0.429 0.003 TF:M03846_1 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 1 1 O00459,P42336,O00329 44 2.23e-02 20 7 1 0.143 0.050 GO:0043276 BP 1 anoikis 1 P42336 44 2.29e-02 293 7 2 0.286 0.007 GO:1904951 BP 1 positive regulation of establishment of protein localization 1 O00459,P27986 44 2.30e-02 1745 7 4 0.571 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 P42338,O00459,P27986,O00329 44 2.31e-02 1224 7 3 0.429 0.002 TF:M03996_0 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 0 1 Q92569,Q9P242,O00329 44 2.33e-02 6 7 1 0.143 0.167 OMIM:167000 omi 1 OVARIAN CANCEROVARIAN CANCER, EPITHELIAL, INCLUDED 1 P42336 44 2.34e-02 21 7 1 0.143 0.048 GO:0002279 BP 1 mast cell activation involved in immune response 1 O00329 44 2.34e-02 21 7 1 0.143 0.048 GO:0045123 BP 1 cellular extravasation 1 O00329 44 2.34e-02 21 7 1 0.143 0.048 GO:0043303 BP 1 mast cell degranulation 1 O00329 44 2.45e-02 22 7 1 0.143 0.045 GO:0002448 BP 1 mast cell mediated immunity 1 O00329 44 2.46e-02 393 7 2 0.286 0.005 HPA:041020_13 hpa 1 spleen; cells in white pulp[Supportive,High] 1 P42336,P27986 44 2.51e-02 6242 7 7 1.000 0.001 GO:0065007 BP 1 biological regulation 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.55e-02 310 7 2 0.286 0.006 GO:0032386 BP 1 regulation of intracellular transport 1 O00459,P27986 44 2.56e-02 47 7 1 0.143 0.021 TF:M07207_1 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 1 1 Q9P242 44 2.56e-02 23 7 1 0.143 0.043 GO:0045576 BP 1 mast cell activation 1 O00329 44 2.56e-02 23 7 1 0.143 0.043 GO:0090004 BP 1 positive regulation of establishment of protein localization to plasma membrane 1 P27986 44 2.57e-02 6266 7 7 1.000 0.001 GO:0044763 BP 1 single-organism cellular process 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.58e-02 1276 7 3 0.429 0.002 TF:M00136_0 tf 1 Factor: Oct-1; motif: NNGAATATKCANNNN; match class: 0 1 P42336,Q9P242,P27986 44 2.61e-02 48 7 1 0.143 0.021 TF:M04386_1 tf 1 Factor: LHX2; motif: YAATTANNCTAATTR; match class: 1 1 P42338 44 2.61e-02 48 7 1 0.143 0.021 TF:M06545_0 tf 1 Factor: ZNF485; motif: NGGGAKGGGGGW; match class: 0 1 Q92569 44 2.61e-02 7563 7 7 1.000 0.001 TF:M00087_0 tf 1 Factor: Ik-2; motif: NNNTGGGAWNNC; match class: 0 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 2.64e-02 481 7 2 0.286 0.004 TF:M02053_1 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 1 O00459,P27986 44 2.66e-02 1291 7 3 0.429 0.002 TF:M00071_0 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 0 1 O00459,Q92569,P42336 44 2.67e-02 24 7 1 0.143 0.042 GO:0030593 BP 1 neutrophil chemotaxis 1 O00329 44 2.67e-02 24 7 1 0.143 0.042 GO:0050853 BP 1 B cell receptor signaling pathway 1 O00329 44 2.68e-02 318 7 2 0.286 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 O00459,P27986 44 2.72e-02 50 7 1 0.143 0.020 TF:M06764_0 tf 1 Factor: ZNF228; motif: NCCGCCGAACCC; match class: 0 1 P42338 44 2.77e-02 51 7 1 0.143 0.020 TF:M06972_0 tf 1 Factor: DUX3; motif: TTAATTTAATTAA; match class: 0 1 P42338 44 2.77e-02 51 7 1 0.143 0.020 TF:M06988_0 tf 1 Factor: DUX4; motif: TTAATTTAATTAA; match class: 0 1 P42338 44 2.78e-02 324 7 2 0.286 0.006 GO:0051169 BP 1 nuclear transport 1 O00459,P27986 44 2.78e-02 25 7 1 0.143 0.040 GO:0072676 BP 1 lymphocyte migration 1 O00329 44 2.78e-02 25 7 1 0.143 0.040 GO:1903078 BP 1 positive regulation of protein localization to plasma membrane 1 P27986 44 2.78e-02 25 7 1 0.143 0.040 GO:1904377 BP 1 positive regulation of protein localization to cell periphery 1 P27986 44 2.86e-02 2436 7 4 0.571 0.002 TF:M01001_0 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 0 1 P42338,O00459,Q92569,P42336 44 2.87e-02 4 7 1 0.143 0.250 CORUM:2551 cor 1 PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated 1 P27986 44 2.87e-02 4 7 1 0.143 0.250 CORUM:2922 cor 1 LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated 1 P27986 44 2.90e-02 26 7 1 0.143 0.038 GO:0030101 BP 1 natural killer cell activation 1 O00329 44 3.01e-02 27 7 1 0.143 0.037 GO:0042562 MF 1 hormone binding 1 P27986 44 3.01e-02 338 7 2 0.286 0.006 GO:0055082 BP 1 cellular chemical homeostasis 1 O00459,P27986 44 3.03e-02 339 7 2 0.286 0.006 GO:0019901 MF 1 protein kinase binding 1 O00459,P27986 44 3.04e-02 7727 7 7 1.000 0.001 TF:M02065_1 tf 1 Factor: ER81; motif: RCCGGAARYN; match class: 1 1 P42338,O00459,Q92569,P42336,Q9P242,P27986,O00329 44 3.05e-02 340 7 2 0.286 0.006 GO:0006914 BP 1 autophagy 1 P42338,O00459 44 3.10e-02 8 7 1 0.143 0.125 OMIM:114550 omi 1 HEPATOCELLULAR CARCINOMA;;HCC;;CANCER, HEPATOCELLULAR;;LIVER CANCER;;LIVER CELL CARCINOMA; LCC;;HEPATOMAHEPATOBLASTOMA, INCLUDED;;HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION, INCLUDED 1 P42336 44 3.12e-02 28 7 1 0.143 0.036 GO:1990266 BP 1 neutrophil migration 1 O00329 44 3.15e-02 3073 7 5 0.714 0.002 GO:0032501 BP 1 multicellular organismal process 1 P42338,P42336,Q9P242,P27986,O00329 44 3.17e-02 2510 7 4 0.571 0.002 TF:M00691_0 tf 1 Factor: ATF1; motif: CYYTGACGTCA; match class: 0 1 P42338,Q92569,Q9P242,P27986 44 3.20e-02 59 7 1 0.143 0.017 TF:M01657_1 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 1 1 O00329 44 3.26e-02 1924 7 4 0.571 0.002 GO:0065008 BP 1 regulation of biological quality 1 P42338,O00459,P42336,P27986 44 3.34e-02 30 7 1 0.143 0.033 GO:0071621 BP 1 granulocyte chemotaxis 1 O00329 44 3.34e-02 30 7 1 0.143 0.033 GO:0043299 BP 1 leukocyte degranulation 1 O00329 44 3.37e-02 5666 7 6 0.857 0.001 TF:M04321_0 tf 1 Factor: EVX2; motif: NNTNATTANN; match class: 0 1 P42338,Q92569,P42336,Q9P242,P27986,O00329 44 3.42e-02 4600 7 6 0.857 0.001 GO:0016020 CC 1 membrane 1 P42338,O00459,Q92569,P42336,P27986,O00329 44 3.45e-02 31 7 1 0.143 0.032 GO:0002275 BP 1 myeloid cell activation involved in immune response 1 O00329 44 3.52e-02 16 7 2 0.286 0.125 HP:0100658 hp 1 Cellulitis 1 P27986,O00329 44 3.54e-02 368 7 2 0.286 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 O00459,P27986 44 3.67e-02 4039 7 5 0.714 0.001 TF:M07354_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 P42338,O00459,P42336,P27986,O00329 44 3.67e-02 33 7 1 0.143 0.030 GO:0002444 BP 1 myeloid leukocyte mediated immunity 1 O00329 44 3.68e-02 2620 7 4 0.571 0.002 TF:M07309_0 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 0 1 P42338,Q92569,Q9P242,O00329 44 3.68e-02 68 7 1 0.143 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 O00459 44 3.69e-02 2622 7 4 0.571 0.002 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 P42338,O00459,Q9P242,P27986 44 3.78e-02 34 7 1 0.143 0.029 GO:0097530 BP 1 granulocyte migration 1 O00329 44 3.79e-02 2644 7 4 0.571 0.002 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 O00459,Q92569,P42336,O00329 44 3.84e-02 71 7 1 0.143 0.014 TF:M05556_0 tf 1 Factor: ZNF784; motif: WSTATAAAGAAA; match class: 0 1 P27986 44 3.86e-02 385 7 2 0.286 0.005 GO:0019725 BP 1 cellular homeostasis 1 O00459,P27986 44 3.88e-02 386 7 2 0.286 0.005 GO:0019900 MF 1 kinase binding 1 O00459,P27986 44 3.89e-02 35 7 1 0.143 0.029 GO:0090003 BP 1 regulation of establishment of protein localization to plasma membrane 1 P27986 44 3.94e-02 4107 7 5 0.714 0.001 TF:M00729_0 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 0 1 P42338,O00459,Q92569,P42336,P27986 44 4.00e-02 36 7 1 0.143 0.028 GO:0045171 CC 1 intercellular bridge 1 P42338 44 4.06e-02 607 7 2 0.286 0.003 TF:M04430_1 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 1 1 P42338,Q9P242 44 4.11e-02 3263 7 5 0.714 0.002 GO:0019222 BP 1 regulation of metabolic process 1 P42338,O00459,Q92569,P27986,O00329 44 4.11e-02 37 7 1 0.143 0.027 GO:0032418 BP 1 lysosome localization 1 O00329 44 4.11e-02 37 7 1 0.143 0.027 GO:0072583 BP 1 clathrin-dependent endocytosis 1 P42338 44 4.28e-02 407 7 2 0.286 0.005 GO:0051223 BP 1 regulation of protein transport 1 O00459,P27986 44 4.29e-02 6 7 1 0.143 0.167 CORUM:2529 cor 1 LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated 1 P27986 44 4.30e-02 408 7 2 0.286 0.005 GO:0043066 BP 1 negative regulation of apoptotic process 1 P42336,P27986 44 4.42e-02 1563 7 3 0.429 0.002 TF:M04149_1 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 1 1 P42338,O00459,O00329 44 4.42e-02 82 7 1 0.143 0.012 TF:M07410_1 tf 1 Factor: RFX2; motif: GTYNCCATGGCAACNGNNN; match class: 1 1 O00459 44 4.46e-02 416 7 2 0.286 0.005 GO:0043069 BP 1 negative regulation of programmed cell death 1 P42336,P27986 44 4.50e-02 2781 7 4 0.571 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 P42338,O00459,P27986,O00329 44 4.61e-02 4263 7 5 0.714 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 Q92569,P42336,Q9P242,P27986,O00329 44 4.63e-02 2804 7 4 0.571 0.001 TF:M04298_0 tf 1 Factor: Cdx-2; motif: GYMATAAAA; match class: 0 1 P42338,O00459,Q92569,P27986 44 4.64e-02 86 7 1 0.143 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 O00459 44 4.66e-02 42 7 1 0.143 0.024 GO:0070527 BP 1 platelet aggregation 1 P42338 44 4.69e-02 87 7 1 0.143 0.011 TF:M02106_1 tf 1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 1 Q92569 44 4.82e-02 1616 7 3 0.429 0.002 TF:M01774_0 tf 1 Factor: TBR2; motif: AGGTGTGAA; match class: 0 1 P42338,P27986,O00329 44 4.83e-02 4310 7 5 0.714 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 O00459,Q92569,P42336,P27986,O00329 44 4.95e-02 92 7 1 0.143 0.011 TF:M04400_1 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 1 1 P42338 44 5.00e-02 2173 7 4 0.571 0.002 GO:0010468 BP 1 regulation of gene expression 1 P42338,O00459,P27986,O00329 44 5.00e-02 323 7 3 0.429 0.009 MI:hsa-miR-143* mi 1 MI:hsa-miR-143* 1 O00459,P42336,O00329 44 5.00e-02 7 7 1 0.143 0.143 CORUM:2480 cor 1 CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) 1 P27986 44 5.00e-02 13 7 1 0.143 0.077 OMIM:211980 omi 1 LUNG CANCERALVEOLAR CELL CARCINOMA, INCLUDED;;ADENOCARCINOMA OF LUNG, INCLUDED;;NONSMALL CELL LUNG CANCER, INCLUDED;;LUNG CANCER, PROTECTION AGAINST, INCLUDED 1 P42336 44 5.00e-02 19 7 2 0.286 0.105 HP:0200043 hp 1 Verrucae 1 P42336,P27986 44 5.00e-02 139 7 2 0.286 0.014 KEGG:05206 keg 1 MicroRNAs in cancer 1 O00459,P42336 45 2.83e-03 12 3 1 0.333 0.083 TF:M05937_0 tf 1 Factor: ZNF582; motif: NKGGTATGAAGM; match class: 0 1 P0CG13 45 3.57e-03 445 3 2 0.667 0.004 TF:M04084_1 tf 1 Factor: POU3F4; motif: TGCATAAWTTA; match class: 1 1 P36537,P22314 45 4.62e-03 446 3 2 0.667 0.004 MI:mmu-miR-670 mi 1 MI:mmu-miR-670 1 P36537,P0CG13 45 5.28e-03 477 3 2 0.667 0.004 MI:hsa-miR-498 mi 1 MI:hsa-miR-498 1 P22314,P0CG13 45 6.79e-03 542 3 2 0.667 0.004 MI:hsa-miR-518d-5p mi 1 MI:hsa-miR-518d-5p 1 P22314,P0CG13 45 6.82e-03 29 3 1 0.333 0.034 TF:M05368_0 tf 1 Factor: ZNF746; motif: NGTGGGTGGGWC; match class: 0 1 P0CG13 45 7.22e-03 2461 3 3 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 P36537,P22314,P0CG13 45 7.80e-03 7 3 1 0.333 0.143 HP:0002828 hp 1 Multiple joint contractures 1 P22314 45 8.23e-03 35 3 1 0.333 0.029 TF:M05525_0 tf 1 Factor: ZBTB41; motif: TGGGCCCCCGA; match class: 0 1 P22314 45 8.93e-03 38 3 1 0.333 0.026 TF:M04044_1 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 1 1 P0CG13 45 8.98e-03 710 3 2 0.667 0.003 TF:M04187_0 tf 1 Factor: OLIG3; motif: AMCATATGNY; match class: 0 1 P36537,P22314 45 1.13e-02 2855 3 3 1.000 0.001 TF:M00955_0 tf 1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 0 1 P36537,P22314,P0CG13 45 1.15e-02 49 3 1 0.333 0.020 TF:M00672_1 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 1 1 P36537 45 1.22e-02 52 3 1 0.333 0.019 TF:M06066_0 tf 1 Factor: ZNF264; motif: NGGGTAWGAGGA; match class: 0 1 P22314 45 1.22e-02 52 3 1 0.333 0.019 TF:M06294_0 tf 1 Factor: ZNF805; motif: NGKGTATGAGGM; match class: 0 1 P22314 45 1.34e-02 57 3 1 0.333 0.018 TF:M06605_0 tf 1 Factor: ZNF681; motif: SGGGGTAAAGM; match class: 0 1 P36537 45 1.39e-02 889 3 2 0.667 0.002 TF:M04044_0 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 0 1 P22314,P0CG13 45 1.55e-02 939 3 2 0.667 0.002 TF:M03843_1 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 1 1 P36537,P22314 45 1.71e-02 987 3 2 0.667 0.002 TF:M04068_1 tf 1 Factor: POU1F1; motif: NNNATGMATAWTTAATN; match class: 1 1 P36537,P22314 45 1.71e-02 73 3 1 0.333 0.014 TF:M03996_1 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 1 1 P36537 45 1.78e-02 76 3 1 0.333 0.013 TF:M04087_1 tf 1 Factor: POU4F3; motif: NTGMATWATTAATGNN; match class: 1 1 P22314 45 1.78e-02 76 3 1 0.333 0.013 TF:M00639_0 tf 1 Factor: HNF-6; motif: HWAAATCAATAW; match class: 0 1 P36537 45 1.85e-02 79 3 1 0.333 0.013 TF:M01111_1 tf 1 Factor: RBP-Jkappa; motif: TTCCCACK; match class: 1 1 P0CG13 45 1.98e-02 3443 3 3 1.000 0.001 TF:M00935_0 tf 1 Factor: NF-AT; motif: NWGGAAANWN; match class: 0 1 P36537,P22314,P0CG13 45 2.05e-02 3485 3 3 1.000 0.001 TF:M04611_0 tf 1 Factor: FOXM1; motif: NAGASTGATTA; match class: 0 1 P36537,P22314,P0CG13 45 2.14e-02 3 3 1 0.333 0.333 GO:0004839 MF 1 ubiquitin activating enzyme activity 1 P22314 45 2.20e-02 1124 3 2 0.667 0.002 TF:M04078_1 tf 1 Factor: POU3F2; motif: NWTGCATAAWTTA; match class: 1 1 P36537,P22314 45 2.22e-02 20 3 1 0.333 0.050 HP:0007269 hp 1 Spinal muscular atrophy 1 P22314 45 2.33e-02 21 3 1 0.333 0.048 HP:0009623 hp 1 Proximal placement of thumb 1 P22314 45 2.39e-02 1174 3 2 0.667 0.002 TF:M04081_1 tf 1 Factor: POU3F3; motif: WTGMATAAWTWA; match class: 1 1 P36537,P22314 45 2.41e-02 103 3 1 0.333 0.010 TF:M00264_1 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 1 1 P22314 45 2.43e-02 3685 3 3 1.000 0.001 TF:M03573_0 tf 1 Factor: FKHL5; motif: ATGTTTAT; match class: 0 1 P36537,P22314,P0CG13 45 2.43e-02 104 3 1 0.333 0.010 TF:M05700_0 tf 1 Factor: ZNF19; motif: KGGGGCTGCTGC; match class: 0 1 P22314 45 2.44e-02 22 3 1 0.333 0.045 HP:0002058 hp 1 Myopathic facies 1 P22314 45 2.55e-02 23 3 1 0.333 0.043 HP:0009603 hp 1 Deviation of the thumb 1 P22314 45 2.58e-02 1220 3 2 0.667 0.002 TF:M04292_1 tf 1 Factor: BSX; motif: NYNATTAN; match class: 1 1 P36537,P0CG13 45 2.62e-02 112 3 1 0.333 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 P22314 45 2.88e-02 3902 3 3 1.000 0.001 TF:M04068_0 tf 1 Factor: POU1F1; motif: NNNATGMATAWTTAATN; match class: 0 1 P36537,P22314,P0CG13 45 2.89e-02 124 3 1 0.333 0.008 TF:M00421_0 tf 1 Factor: MEIS1B:HOXA9; motif: TGACASTTTWAYRR; match class: 0 1 P22314 45 2.98e-02 1316 3 2 0.667 0.002 TF:M04182_0 tf 1 Factor: NEUROD2; motif: RMCATATGKY; match class: 0 1 P36537,P0CG13 45 3.25e-02 4062 3 3 1.000 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 P36537,P22314,P0CG13 45 3.64e-02 33 3 1 0.333 0.030 HP:0000474 hp 1 Thickened nuchal skin fold 1 P22314 45 3.70e-02 159 3 1 0.333 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 P0CG13 45 3.75e-02 4260 3 3 1.000 0.001 TF:M00474_0 tf 1 Factor: FOXO1; motif: GNNTTGTTTACNTT; match class: 0 1 P36537,P22314,P0CG13 45 3.86e-02 35 3 1 0.333 0.029 HP:0002398 hp 1 Degeneration of anterior horn cells 1 P22314 45 3.86e-02 35 3 1 0.333 0.029 HP:0001308 hp 1 Tongue fasciculations 1 P22314 45 3.93e-02 169 3 1 0.333 0.006 TF:M04085_1 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 1 1 P22314 45 3.93e-02 1519 3 2 0.667 0.001 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 P36537,P0CG13 45 3.97e-02 36 3 1 0.333 0.028 HP:0006802 hp 1 Abnormal anterior horn cell morphology 1 P22314 45 3.98e-02 1529 3 2 0.667 0.001 TF:M07384_0 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 0 1 P22314,P0CG13 45 4.00e-02 20 3 1 0.333 0.050 KEGG:00053 keg 1 Ascorbate and aldarate metabolism 1 P36537 45 4.08e-02 37 3 1 0.333 0.027 HP:0010546 hp 1 Muscle fibrillation 1 P22314 45 4.09e-02 4385 3 3 1.000 0.001 TF:M07058_0 tf 1 Factor: POU2F1; motif: ATTTGCATN; match class: 0 1 P36537,P22314,P0CG13 45 4.14e-02 178 3 1 0.333 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 P22314 45 4.16e-02 179 3 1 0.333 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 P0CG13 45 4.18e-02 38 3 1 0.333 0.026 HP:0006829 hp 1 Severe muscular hypotonia 1 P22314 45 4.41e-02 1614 3 2 0.667 0.001 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 P36537,P0CG13 45 4.44e-02 191 3 1 0.333 0.005 TF:M07230_0 tf 1 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG; match class: 0 1 P22314 45 4.64e-02 4573 3 3 1.000 0.001 TF:M00138_0 tf 1 Factor: Oct-1; motif: NNNNNNNWATGCAAATNNNWNNA; match class: 0 1 P36537,P22314,P0CG13 45 4.65e-02 1659 3 2 0.667 0.001 TF:M01013_0 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 0 1 P36537,P22314 45 4.83e-02 44 3 1 0.333 0.023 HP:0007373 hp 1 Motor neuron atrophy 1 P22314 45 4.87e-02 210 3 1 0.333 0.005 TF:M06245_0 tf 1 Factor: ZNF763; motif: NGAATAAGCCNT; match class: 0 1 P36537 45 5.00e-02 7 3 1 0.333 0.143 GO:1900262 BP 1 regulation of DNA-directed DNA polymerase activity 1 P0CG13 45 5.00e-02 1 3 1 0.333 1.000 OMIM:301830 omi 1 SPINAL MUSCULAR ATROPHY, X-LINKED 2; SMAX2;;SPINAL MUSCULAR ATROPHY, X-LINKED LETHAL INFANTILE;;SPINAL MUSCULAR ATROPHY, INFANTILE X-LINKED; XLSMA;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, X-LINKED;;AMC, DISTAL, X-LINKED;;ARTHROGRYPOSIS, X-LINKED, TYPE I; AMCX1 1 P22314 45 5.00e-02 25 3 1 0.333 0.040 KEGG:00040 keg 1 Pentose and glucuronate interconversions 1 P36537 45 5.00e-02 7 3 1 0.333 0.143 GO:0003689 MF 1 DNA clamp loader activity 1 P0CG13 45 5.00e-02 7 3 1 0.333 0.143 GO:0033170 MF 1 protein-DNA loading ATPase activity 1 P0CG13 45 5.00e-02 7 3 1 0.333 0.143 GO:1900264 BP 1 positive regulation of DNA-directed DNA polymerase activity 1 P0CG13 45 5.00e-02 15 3 1 0.333 0.067 REAC:156588 rea 1 Glucuronidation 1 P36537 46 1.31e-06 3 4 2 0.500 0.667 GO:0052812 MF 1 phosphatidylinositol-3,4-bisphosphate 5-kinase activity 1 Q99755,O60331 46 4.35e-06 5 4 2 0.500 0.400 GO:0052811 MF 1 1-phosphatidylinositol-3-phosphate 4-kinase activity 1 Q99755,O60331 46 6.52e-06 6 4 2 0.500 0.333 GO:0016308 MF 1 1-phosphatidylinositol-4-phosphate 5-kinase activity 1 Q99755,O60331 46 3.95e-05 14 4 2 0.500 0.143 GO:0016307 MF 1 phosphatidylinositol phosphate kinase activity 1 Q99755,O60331 46 1.82e-04 246 4 3 0.750 0.012 GO:0042330 BP 1 taxis 1 Q9HDB5,Q99755,O60331 46 1.82e-04 246 4 3 0.750 0.012 GO:0006935 BP 1 chemotaxis 1 Q9HDB5,Q99755,O60331 46 2.87e-04 44 4 2 0.500 0.045 REAC:1660499 rea 1 Synthesis of PIPs at the plasma membrane 1 Q99755,O60331 46 3.73e-04 42 4 2 0.500 0.048 GO:0052813 MF 1 phosphatidylinositol bisphosphate kinase activity 1 Q99755,O60331 46 5.74e-04 52 4 2 0.500 0.038 GO:0034333 BP 1 adherens junction assembly 1 Q99755,O60331 46 6.09e-04 64 4 2 0.500 0.031 REAC:6811558 rea 1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1 Q99755,O60331 46 6.88e-04 68 4 2 0.500 0.029 REAC:1483255 rea 1 PI Metabolism 1 Q99755,O60331 46 7.50e-04 71 4 2 0.500 0.028 REAC:199418 rea 1 Negative regulation of the PI3K/AKT network 1 Q99755,O60331 46 9.88e-04 66 4 2 0.500 0.030 KEGG:00562 keg 1 Inositol phosphate metabolism 1 Q99755,O60331 46 1.13e-03 73 4 2 0.500 0.027 GO:0034332 BP 1 adherens junction organization 1 Q99755,O60331 46 1.36e-03 80 4 2 0.500 0.025 GO:0006661 BP 1 phosphatidylinositol biosynthetic process 1 Q99755,O60331 46 1.40e-03 81 4 2 0.500 0.025 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:5654689 rea 1 PI-3K cascade:FGFR1 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:1257604 rea 1 PIP3 activates AKT signaling 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:5654720 rea 1 PI-3K cascade:FGFR4 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:1250342 rea 1 PI3K events in ERBB4 signaling 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:5654710 rea 1 PI-3K cascade:FGFR3 1 Q99755,O60331 46 1.49e-03 100 4 2 0.500 0.020 REAC:5654695 rea 1 PI-3K cascade:FGFR2 1 Q99755,O60331 46 1.55e-03 102 4 2 0.500 0.020 REAC:198203 rea 1 PI3K/AKT activation 1 Q99755,O60331 46 1.58e-03 103 4 2 0.500 0.019 REAC:180292 rea 1 GAB1 signalosome 1 Q99755,O60331 46 1.64e-03 85 4 2 0.500 0.024 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 Q99755,O60331 46 1.64e-03 105 4 2 0.500 0.019 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 Q99755,O60331 46 1.68e-03 86 4 2 0.500 0.023 KEGG:05231 keg 1 Choline metabolism in cancer 1 Q99755,O60331 46 1.79e-03 89 4 2 0.500 0.022 KEGG:04070 keg 1 Phosphatidylinositol signaling system 1 Q99755,O60331 46 1.88e-03 94 4 2 0.500 0.021 GO:0014065 BP 1 phosphatidylinositol 3-kinase signaling 1 Q99755,O60331 46 2.17e-03 101 4 2 0.500 0.020 GO:0060326 BP 1 cell chemotaxis 1 Q99755,O60331 46 2.22e-03 102 4 2 0.500 0.020 GO:0046488 BP 1 phosphatidylinositol metabolic process 1 Q99755,O60331 46 2.96e-03 118 4 2 0.500 0.017 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 Q99755,O60331 46 3.01e-03 119 4 2 0.500 0.017 GO:0048017 BP 1 inositol lipid-mediated signaling 1 Q99755,O60331 46 3.04e-03 614 4 3 0.750 0.005 REAC:1280218 rea 1 Adaptive Immune System 1 Q99755,Q8WV44,O60331 46 3.08e-03 117 4 2 0.500 0.017 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 Q99755,O60331 46 3.35e-03 2 4 1 0.250 0.500 GO:0052810 MF 1 1-phosphatidylinositol-5-kinase activity 1 Q99755 46 3.35e-03 2 4 1 0.250 0.500 GO:0000285 MF 1 1-phosphatidylinositol-3-phosphate 5-kinase activity 1 Q99755 46 3.43e-03 127 4 2 0.500 0.016 GO:0034329 BP 1 cell junction assembly 1 Q99755,O60331 46 3.71e-03 132 4 2 0.500 0.015 GO:0045216 BP 1 cell-cell junction organization 1 Q99755,O60331 46 3.73e-03 678 4 3 0.750 0.004 GO:0007155 BP 1 cell adhesion 1 Q9HDB5,Q99755,O60331 46 3.83e-03 684 4 3 0.750 0.004 GO:0022610 BP 1 biological adhesion 1 Q9HDB5,Q99755,O60331 46 4.01e-03 165 4 2 0.500 0.012 REAC:1483257 rea 1 Phospholipid metabolism 1 Q99755,O60331 46 4.16e-03 168 4 2 0.500 0.012 REAC:1168372 rea 1 Downstream signaling events of B Cell Receptor (BCR) 1 Q99755,O60331 46 4.29e-03 142 4 2 0.500 0.014 GO:0006909 BP 1 phagocytosis 1 Q99755,O60331 46 4.41e-03 144 4 2 0.500 0.014 GO:0046474 BP 1 glycerophospholipid biosynthetic process 1 Q99755,O60331 46 5.14e-03 187 4 2 0.500 0.011 REAC:983705 rea 1 Signaling by the B Cell Receptor (BCR) 1 Q99755,O60331 46 5.17e-03 156 4 2 0.500 0.013 GO:0034330 BP 1 cell junction organization 1 Q99755,O60331 46 5.30e-03 158 4 2 0.500 0.013 GO:0008654 BP 1 phospholipid biosynthetic process 1 Q99755,O60331 46 5.64e-03 163 4 2 0.500 0.012 GO:0045017 BP 1 glycerolipid biosynthetic process 1 Q99755,O60331 46 6.09e-03 3017 4 4 1.000 0.001 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 Q9HDB5,Q99755,Q8WV44,O60331 46 6.40e-03 814 4 3 0.750 0.004 GO:0040011 BP 1 locomotion 1 Q9HDB5,Q99755,O60331 46 6.69e-03 4 4 1 0.250 0.250 GO:0097109 MF 1 neuroligin family protein binding 1 Q9HDB5 46 6.81e-03 175 4 2 0.500 0.011 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 Q99755,O60331 46 6.90e-03 835 4 3 0.750 0.004 GO:0009605 BP 1 response to external stimulus 1 Q9HDB5,Q99755,O60331 46 7.72e-03 191 4 2 0.500 0.010 GO:0006650 BP 1 glycerophospholipid metabolic process 1 Q99755,O60331 46 8.36e-03 1 4 1 0.250 1.000 OMIM:611369 omi 1 LETHAL CONGENITAL CONTRACTURE SYNDROME 3; LCCS3;;MULTIPLE CONTRACTURE SYNDROME, ISRAELI BEDOUIN TYPE B 1 O60331 46 9.36e-03 455 4 2 0.500 0.004 MI:mmu-miR-714 mi 1 MI:mmu-miR-714 1 Q99755,O60331 46 9.55e-03 13 4 1 0.250 0.077 REAC:399955 rea 1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1 O60331 46 1.00e-02 6 4 1 0.250 0.167 GO:0031254 CC 1 cell trailing edge 1 O60331 46 1.00e-02 6 4 1 0.250 0.167 GO:0001931 CC 1 uropod 1 O60331 46 1.06e-02 271 4 2 0.500 0.007 REAC:1433557 rea 1 Signaling by SCF-KIT 1 Q99755,O60331 46 1.07e-02 272 4 2 0.500 0.007 REAC:1236394 rea 1 Signaling by ERBB4 1 Q99755,O60331 46 1.13e-02 280 4 2 0.500 0.007 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 Q99755,O60331 46 1.13e-02 280 4 2 0.500 0.007 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 Q99755,O60331 46 1.13e-02 280 4 2 0.500 0.007 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 Q99755,O60331 46 1.14e-02 281 4 2 0.500 0.007 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 Q99755,O60331 46 1.15e-02 229 4 2 0.500 0.009 KEGG:04144 keg 1 Endocytosis 1 Q99755,O60331 46 1.16e-02 283 4 2 0.500 0.007 REAC:5654741 rea 1 Signaling by FGFR3 1 Q99755,O60331 46 1.16e-02 283 4 2 0.500 0.007 REAC:5654743 rea 1 Signaling by FGFR4 1 Q99755,O60331 46 1.17e-02 285 4 2 0.500 0.007 REAC:5654736 rea 1 Signaling by FGFR1 1 Q99755,O60331 46 1.20e-02 239 4 2 0.500 0.008 GO:0046486 BP 1 glycerolipid metabolic process 1 Q99755,O60331 46 1.21e-02 240 4 2 0.500 0.008 GO:0006644 BP 1 phospholipid metabolic process 1 Q99755,O60331 46 1.21e-02 290 4 2 0.500 0.007 REAC:2424491 rea 1 DAP12 signaling 1 Q99755,O60331 46 1.23e-02 1016 4 3 0.750 0.003 GO:0006928 BP 1 movement of cell or subcellular component 1 Q9HDB5,Q99755,O60331 46 1.23e-02 292 4 2 0.500 0.007 REAC:186763 rea 1 Downstream signal transduction 1 Q99755,O60331 46 1.25e-02 294 4 2 0.500 0.007 REAC:2172127 rea 1 DAP12 interactions 1 Q99755,O60331 46 1.33e-02 304 4 2 0.500 0.007 REAC:177929 rea 1 Signaling by EGFR 1 Q99755,O60331 46 1.34e-02 8 4 1 0.250 0.125 GO:0071625 BP 1 vocalization behavior 1 Q9HDB5 46 1.34e-02 305 4 2 0.500 0.007 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 Q99755,O60331 46 1.37e-02 309 4 2 0.500 0.006 REAC:5654738 rea 1 Signaling by FGFR2 1 Q99755,O60331 46 1.39e-02 311 4 2 0.500 0.006 REAC:190236 rea 1 Signaling by FGFR 1 Q99755,O60331 46 1.40e-02 312 4 2 0.500 0.006 REAC:186797 rea 1 Signaling by PDGF 1 Q99755,O60331 46 1.49e-02 322 4 2 0.500 0.006 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 Q99755,O60331 46 1.84e-02 11 4 1 0.250 0.091 GO:0007158 BP 1 neuron cell-cell adhesion 1 Q9HDB5 46 2.17e-02 13 4 1 0.250 0.077 GO:0005847 CC 1 mRNA cleavage and polyadenylation specificity factor complex 1 Q99755 46 2.17e-02 13 4 1 0.250 0.077 GO:0048488 BP 1 synaptic vesicle endocytosis 1 O60331 46 2.20e-02 394 4 2 0.500 0.005 REAC:166520 rea 1 Signalling by NGF 1 Q99755,O60331 46 2.31e-02 333 4 2 0.500 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 Q99755,O60331 46 2.31e-02 333 4 2 0.500 0.006 GO:0005925 CC 1 focal adhesion 1 Q99755,O60331 46 2.33e-02 334 4 2 0.500 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 Q99755,O60331 46 2.33e-02 334 4 2 0.500 0.006 GO:0016337 BP 1 single organismal cell-cell adhesion 1 Q9HDB5,O60331 46 2.37e-02 337 4 2 0.500 0.006 GO:0030055 CC 1 cell-substrate junction 1 Q99755,O60331 46 2.50e-02 15 4 1 0.250 0.067 GO:0097178 BP 1 ruffle assembly 1 Q99755 46 2.61e-02 354 4 2 0.500 0.006 GO:0006897 BP 1 endocytosis 1 Q99755,O60331 46 2.67e-02 358 4 2 0.500 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 Q99755,O60331 46 2.80e-02 367 4 2 0.500 0.005 GO:0008610 BP 1 lipid biosynthetic process 1 Q99755,O60331 46 2.84e-02 17 4 1 0.250 0.059 GO:0072661 BP 1 protein targeting to plasma membrane 1 Q99755 46 2.84e-02 17 4 1 0.250 0.059 GO:0036465 BP 1 synaptic vesicle recycling 1 O60331 46 2.84e-02 17 4 1 0.250 0.059 GO:0005849 CC 1 mRNA cleavage factor complex 1 Q99755 46 2.85e-02 370 4 2 0.500 0.005 GO:0098602 BP 1 single organism cell adhesion 1 Q9HDB5,O60331 46 3.14e-02 389 4 2 0.500 0.005 GO:0098609 BP 1 cell-cell adhesion 1 Q9HDB5,O60331 46 3.17e-02 19 4 1 0.250 0.053 GO:0035176 BP 1 social behavior 1 Q9HDB5 46 3.17e-02 19 4 1 0.250 0.053 GO:0051703 BP 1 intraspecies interaction between organisms 1 Q9HDB5 46 3.50e-02 21 4 1 0.250 0.048 GO:0051705 BP 1 multi-organism behavior 1 Q9HDB5 46 3.63e-02 419 4 2 0.500 0.005 GO:0030029 BP 1 actin filament-based process 1 Q99755,O60331 46 3.70e-02 1457 4 3 0.750 0.002 REAC:168256 rea 1 Immune System 1 Q99755,Q8WV44,O60331 46 4.00e-02 24 4 1 0.250 0.042 GO:0031529 BP 1 ruffle organization 1 Q99755 46 4.00e-02 24 4 1 0.250 0.042 GO:0030593 BP 1 neutrophil chemotaxis 1 O60331 46 4.29e-02 59 4 1 0.250 0.017 REAC:373755 rea 1 Semaphorin interactions 1 O60331 46 4.50e-02 27 4 1 0.250 0.037 GO:0030534 BP 1 adult behavior 1 Q9HDB5 46 4.67e-02 28 4 1 0.250 0.036 GO:1990266 BP 1 neutrophil migration 1 O60331 46 5.00e-02 606 4 2 0.500 0.003 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 Q99755,O60331 46 5.00e-02 1 4 1 0.250 1.000 TF:M04528_1 tf 1 Factor: SOX14; motif: TCAATANCATTGA; match class: 1 1 O60331 46 5.00e-02 10 4 1 0.250 0.100 HP:0005684 hp 1 Distal arthrogryposis 1 O60331 46 5.00e-02 1 4 1 0.250 1.000 TF:M04537_1 tf 1 Factor: SOX21; motif: TCAATGNTATTGA; match class: 1 1 O60331 46 5.00e-02 6 4 1 0.250 0.167 OMIM:253310 omi 1 Lethal Congenital Contracture Syndrome 1 O60331 46 5.00e-02 1 4 1 0.250 1.000 TF:M04557_1 tf 1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 1 O60331 46 5.00e-02 30 4 1 0.250 0.033 GO:0071621 BP 1 granulocyte chemotaxis 1 O60331 47 5.99e-04 394 8 4 0.500 0.010 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 P22087,Q8IWA0,Q96RS0,Q15061 47 9.36e-04 1502 8 5 0.625 0.003 TF:M01783_0 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,P35789 47 1.88e-03 3 8 1 0.125 0.333 TF:M04508_0 tf 1 Factor: PRDM4; motif: TTTCAAGGCCCCC; match class: 0 1 Q8IWA0 47 2.18e-03 1016 8 4 0.500 0.004 TF:M06727_0 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 0 1 Q9Y2T7,Q8IWA0,Q15061,P35789 47 2.22e-03 116 8 2 0.250 0.017 TF:M05781_0 tf 1 Factor: ZNF699; motif: NTGTCGGGCAGM; match class: 0 1 P22087,Q15061 47 2.86e-03 229 8 3 0.375 0.013 GO:0006364 BP 1 rRNA processing 1 P22087,Q8IWA0,Q15061 47 2.92e-03 45 8 2 0.250 0.044 GO:0008173 MF 1 RNA methyltransferase activity 1 P22087,Q96RS0 47 2.97e-03 232 8 3 0.375 0.013 GO:0016072 BP 1 rRNA metabolic process 1 P22087,Q8IWA0,Q15061 47 3.47e-03 49 8 2 0.250 0.041 GO:0001510 BP 1 RNA methylation 1 P22087,Q96RS0 47 3.63e-03 3013 8 7 0.875 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 4.03e-03 645 8 4 0.500 0.006 GO:0005730 CC 1 nucleolus 1 Q9Y2T7,P22087,Q15061,Q96BK5 47 4.06e-03 53 8 2 0.250 0.038 GO:0044452 CC 1 nucleolar part 1 P22087,Q15061 47 4.94e-03 1 8 1 0.125 1.000 GO:0000494 BP 1 box C/D snoRNA 3'-end processing 1 P22087 47 4.94e-03 1 8 1 0.125 1.000 GO:1990258 BP 1 histone glutamine methylation 1 P22087 47 4.94e-03 1 8 1 0.125 1.000 GO:0071164 MF 1 RNA trimethylguanosine synthase activity 1 Q96RS0 47 4.94e-03 1 8 1 0.125 1.000 GO:0036261 BP 1 7-methylguanosine cap hypermethylation 1 Q96RS0 47 4.94e-03 1 8 1 0.125 1.000 GO:0034963 BP 1 box C/D snoRNA processing 1 P22087 47 4.94e-03 1 8 1 0.125 1.000 GO:0033967 BP 1 box C/D snoRNA metabolic process 1 P22087 47 4.94e-03 1 8 1 0.125 1.000 GO:1990259 MF 1 histone-glutamine methyltransferase activity 1 P22087 47 4.94e-03 1 8 1 0.125 1.000 GO:0036009 MF 1 protein-glutamine N-methyltransferase activity 1 P22087 47 5.05e-03 278 8 3 0.375 0.011 GO:0042254 BP 1 ribosome biogenesis 1 P22087,Q8IWA0,Q15061 47 6.89e-03 11 8 1 0.125 0.091 TF:M01182_1 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 1 1 Q9Y2T7 47 7.23e-03 752 8 4 0.500 0.005 GO:0006396 BP 1 RNA processing 1 P22087,Q8IWA0,Q96RS0,Q15061 47 7.52e-03 12 8 1 0.125 0.083 TF:M06400_0 tf 1 Factor: ZNF497; motif: NCSTCCGTCRSA; match class: 0 1 Q9Y2T7 47 8.14e-03 13 8 1 0.125 0.077 TF:M05515_0 tf 1 Factor: ZNF280B; motif: NRATCMAATAGA; match class: 0 1 Q96BK5 47 8.85e-03 3443 8 7 0.875 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 9.07e-03 1499 8 4 0.500 0.003 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 Q9Y2T7,P22087,Q15061,Q96BK5 47 9.22e-03 80 8 2 0.250 0.025 GO:0051053 BP 1 negative regulation of DNA metabolic process 1 P35789,Q96BK5 47 9.70e-03 348 8 3 0.375 0.009 GO:0034470 BP 1 ncRNA processing 1 P22087,Q8IWA0,Q15061 47 9.88e-03 2 8 1 0.125 0.500 GO:0070894 BP 1 regulation of transposon integration 1 P35789 47 9.88e-03 2 8 1 0.125 0.500 GO:0070893 BP 1 transposon integration 1 P35789 47 9.88e-03 2 8 1 0.125 0.500 GO:0071167 BP 1 ribonucleoprotein complex import into nucleus 1 Q96RS0 47 9.88e-03 2 8 1 0.125 0.500 GO:1904744 BP 1 positive regulation of telomeric DNA binding 1 Q96BK5 47 9.88e-03 2 8 1 0.125 0.500 GO:0009386 BP 1 translational attenuation 1 Q9Y2T7 47 9.88e-03 2 8 1 0.125 0.500 GO:0070895 BP 1 negative regulation of transposon integration 1 P35789 47 1.03e-02 254 8 2 0.250 0.008 TF:M02010_1 tf 1 Factor: Gfi1; motif: CNSNGATTTN; match class: 1 1 Q15061,Q96BK5 47 1.09e-02 3554 8 7 0.875 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 1.11e-02 3561 8 7 0.875 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 1.13e-02 18 8 1 0.125 0.056 TF:M06970_0 tf 1 Factor: ZNF740; motif: TGGGGATCCCCC; match class: 0 1 Q8IWA0 47 1.13e-02 18 8 1 0.125 0.056 TF:M04164_1 tf 1 Factor: BHLHE22; motif: AAACATATGKTN; match class: 1 1 Q9ULW6 47 1.13e-02 18 8 1 0.125 0.056 TF:M04164_0 tf 1 Factor: BHLHE22; motif: AAACATATGKTN; match class: 0 1 Q9ULW6 47 1.13e-02 18 8 1 0.125 0.056 TF:M06992_0 tf 1 Factor: PLAGL2; motif: GGGGGATCCCCA; match class: 0 1 Q8IWA0 47 1.17e-02 2618 8 5 0.625 0.002 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q9ULW6 47 1.19e-02 91 8 2 0.250 0.022 GO:0000776 CC 1 kinetochore 1 Q15061,Q96BK5 47 1.32e-02 290 8 2 0.250 0.007 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 Q9Y2T7,Q96BK5 47 1.34e-02 1672 8 4 0.500 0.002 TF:M01725_0 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,P35789 47 1.37e-02 22 8 1 0.125 0.045 TF:M06256_0 tf 1 Factor: ZNF177; motif: NCYGGCGGRYCC; match class: 0 1 Q15061 47 1.38e-02 3681 8 7 0.875 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 1.48e-02 1719 8 4 0.500 0.002 TF:M07323_1 tf 1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 1 P22087,Q8IWA0,Q96RS0,Q9ULW6 47 1.48e-02 3 8 1 0.125 0.333 GO:1904749 BP 1 regulation of protein localization to nucleolus 1 Q96BK5 47 1.48e-02 3 8 1 0.125 0.333 GO:0018364 BP 1 peptidyl-glutamine methylation 1 P22087 47 1.48e-02 3 8 1 0.125 0.333 GO:1904751 BP 1 positive regulation of protein localization to nucleolus 1 Q96BK5 47 1.48e-02 3 8 1 0.125 0.333 GO:0001094 MF 1 TFIID-class transcription factor binding 1 P22087 47 1.48e-02 3 8 1 0.125 0.333 GO:1904742 BP 1 regulation of telomeric DNA binding 1 Q96BK5 47 1.48e-02 3 8 1 0.125 0.333 GO:0001650 CC 1 fibrillar center 1 Q15061 47 1.48e-02 308 8 2 0.250 0.006 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q8IWA0,Q9ULW6 47 1.52e-02 103 8 2 0.250 0.019 GO:0009451 BP 1 RNA modification 1 P22087,Q96RS0 47 1.53e-02 5576 8 7 0.875 0.001 TF:M07323_0 tf 1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,Q9ULW6,Q96BK5 47 1.55e-02 909 8 3 0.375 0.003 TF:M00258_0 tf 1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 0 1 Q15061,P35789,Q9ULW6 47 1.56e-02 25 8 1 0.125 0.040 TF:M06029_0 tf 1 Factor: ZNF197; motif: NATACCAYCATA; match class: 0 1 P35789 47 1.78e-02 339 8 2 0.250 0.006 TF:M01201_0 tf 1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 0 1 Q96RS0,Q96BK5 47 1.80e-02 2627 8 6 0.750 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789 47 1.80e-02 341 8 2 0.250 0.006 TF:M00322_1 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 1 1 Q96RS0,Q15061 47 1.83e-02 4185 8 6 0.750 0.001 TF:M03797_1 tf 1 Factor: Msx-2; motif: TWWTTGGDGABN; match class: 1 1 P22087,Q8IWA0,Q96RS0,Q15061,Q9ULW6,Q96BK5 47 1.94e-02 1859 8 4 0.500 0.002 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 Q9Y2T7,Q8IWA0,Q15061,Q96BK5 47 1.97e-02 4 8 1 0.125 0.250 GO:1902570 BP 1 protein localization to nucleolus 1 Q96BK5 47 1.97e-02 4 8 1 0.125 0.250 GO:0001091 MF 1 RNA polymerase II basal transcription factor binding 1 P22087 47 1.99e-02 32 8 1 0.125 0.031 TF:M06687_0 tf 1 Factor: ZNF334; motif: NGGGRTTYCATW; match class: 0 1 Q15061 47 2.02e-02 449 8 3 0.375 0.007 GO:0006325 BP 1 chromatin organization 1 P22087,Q8IWA0,Q9ULW6 47 2.03e-02 1882 8 4 0.500 0.002 TF:M01058_0 tf 1 Factor: Gfi1b; motif: TAAATCACTGCW; match class: 0 1 Q8IWA0,Q15061,P35789,Q96BK5 47 2.04e-02 5838 8 7 0.875 0.001 TF:M00791_1 tf 1 Factor: HNF3; motif: NWRARYAAAYANN; match class: 1 1 Q9Y2T7,Q8IWA0,Q96RS0,Q15061,P35789,Q9ULW6,Q96BK5 47 2.09e-02 121 8 2 0.250 0.017 GO:0000775 CC 1 chromosome, centromeric region 1 Q15061,Q96BK5 47 2.14e-02 374 8 2 0.250 0.005 TF:M03902_0 tf 1 Factor: GLI2; motif: GCGACCACMCTR; match class: 0 1 Q96RS0,P35789 47 2.19e-02 3948 8 7 0.875 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 2.24e-02 36 8 1 0.125 0.028 TF:M04161_0 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 0 1 Q9ULW6 47 2.24e-02 36 8 1 0.125 0.028 TF:M04161_1 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 1 1 Q9ULW6 47 2.25e-02 382 8 3 0.375 0.008 MI:hsa-miR-500 mi 1 MI:hsa-miR-500 1 Q9Y2T7,Q15061,Q96BK5 47 2.37e-02 394 8 2 0.250 0.005 TF:M00953_0 tf 1 Factor: AR; motif: NNNGNRRGNACANNGTGTTCTNNNNNN; match class: 0 1 Q9ULW6,Q96BK5 47 2.44e-02 1076 8 3 0.375 0.003 TF:M00623_1 tf 1 Factor: Crx; motif: YNNNTAATCYSMN; match class: 1 1 Q96RS0,Q15061,Q9ULW6 47 2.47e-02 5 8 1 0.125 0.200 GO:0031428 CC 1 box C/D snoRNP complex 1 P22087 47 2.47e-02 5 8 1 0.125 0.200 GO:0048254 BP 1 snoRNA localization 1 P22087 47 2.54e-02 409 8 2 0.250 0.005 TF:M07321_1 tf 1 Factor: HNF-4A; motif: NGNNCAAAGKYCAN; match class: 1 1 P35789,Q96BK5 47 2.55e-02 41 8 1 0.125 0.024 TF:M00650_0 tf 1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 0 1 Q9ULW6 47 2.59e-02 3143 8 5 0.625 0.002 TF:M01744_0 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 0 1 Q9Y2T7,Q96RS0,Q15061,P35789,Q9ULW6 47 2.61e-02 42 8 1 0.125 0.024 TF:M05917_0 tf 1 Factor: ZNF768; motif: NRGTCAAGMAGA; match class: 0 1 Q96BK5 47 2.62e-02 492 8 3 0.375 0.006 GO:0034660 BP 1 ncRNA metabolic process 1 P22087,Q8IWA0,Q15061 47 2.78e-02 3197 8 5 0.625 0.002 TF:M04399_1 tf 1 Factor: MEOX2; motif: NSTAATTANN; match class: 1 1 P22087,Q96RS0,P35789,Q9ULW6,Q96BK5 47 2.79e-02 45 8 1 0.125 0.022 TF:M06367_0 tf 1 Factor: ZNF530; motif: KGGGGAAAAAKA; match class: 0 1 P35789 47 2.88e-02 438 8 2 0.250 0.005 TF:M00956_0 tf 1 Factor: AR; motif: NNNNNNRGNACRNNGTGTTCTNNNNNN; match class: 0 1 Q9ULW6,Q96BK5 47 2.88e-02 438 8 2 0.250 0.005 TF:M05480_0 tf 1 Factor: TLX; motif: AAAAATCARK; match class: 0 1 Q8IWA0,Q9ULW6 47 2.96e-02 6 8 1 0.125 0.167 GO:0010528 BP 1 regulation of transposition 1 P35789 47 2.96e-02 6 8 1 0.125 0.167 GO:2000574 BP 1 regulation of microtubule motor activity 1 Q15061 47 2.96e-02 6 8 1 0.125 0.167 GO:0015074 BP 1 DNA integration 1 P35789 47 2.96e-02 6 8 1 0.125 0.167 GO:0010529 BP 1 negative regulation of transposition 1 P35789 47 2.98e-02 145 8 2 0.250 0.014 GO:0008168 MF 1 methyltransferase activity 1 P22087,Q96RS0 47 3.04e-02 49 8 1 0.125 0.020 TF:M06325_0 tf 1 Factor: ZNF585A; motif: ATGTNTAAAAWC; match class: 0 1 Q96RS0 47 3.06e-02 1171 8 3 0.375 0.003 TF:M07057_1 tf 1 Factor: Pitx3; motif: GATTANA; match class: 1 1 Q15061,P35789,Q9ULW6 47 3.10e-02 1177 8 3 0.375 0.003 TF:M05546_0 tf 1 Factor: EOS; motif: TGGTTATM; match class: 0 1 P22087,Q96RS0,Q15061 47 3.16e-02 460 8 2 0.250 0.004 TF:M01031_1 tf 1 Factor: HNF-4; motif: NGGNCAAAGKYCAN; match class: 1 1 P35789,Q96BK5 47 3.28e-02 2931 8 6 0.750 0.002 GO:0031981 CC 1 nuclear lumen 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,Q96BK5 47 3.29e-02 2166 8 4 0.500 0.002 TF:M03891_1 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 1 1 P22087,Q15061,Q9ULW6,Q96BK5 47 3.31e-02 153 8 2 0.250 0.013 GO:0016741 MF 1 transferase activity, transferring one-carbon groups 1 P22087,Q96RS0 47 3.31e-02 8315 8 8 1.000 0.001 TF:M01035_0 tf 1 Factor: YY1; motif: NYNKCCATNTT; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q9ULW6,Q96BK5 47 3.35e-02 1932 8 5 0.625 0.003 GO:0044085 BP 1 cellular component biogenesis 1 P22087,Q8IWA0,Q96RS0,Q15061,Q9ULW6 47 3.39e-02 3351 8 5 0.625 0.001 TF:M04332_0 tf 1 Factor: HMBOX1; motif: MYTAGTTAMN; match class: 0 1 Q8IWA0,Q96RS0,P35789,Q9ULW6,Q96BK5 47 3.45e-02 7 8 1 0.125 0.143 GO:0010521 MF 1 telomerase inhibitor activity 1 Q96BK5 47 3.45e-02 7 8 1 0.125 0.143 GO:0031126 BP 1 snoRNA 3'-end processing 1 P22087 47 3.45e-02 7 8 1 0.125 0.143 GO:0007097 BP 1 nuclear migration 1 Q15061 47 3.54e-02 4759 8 6 0.750 0.001 TF:M07370_1 tf 1 Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 1 Q9Y2T7,P22087,Q96RS0,Q15061,P35789,Q9ULW6 47 3.59e-02 58 8 1 0.125 0.017 TF:M06232_0 tf 1 Factor: ZNF234; motif: NGTGCAAAAYKG; match class: 0 1 Q15061 47 3.63e-02 4264 8 7 0.875 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 3.63e-02 3408 8 5 0.625 0.001 TF:M07257_1 tf 1 Factor: HOXA10; motif: TTATNNYWN; match class: 1 1 Q8IWA0,Q96RS0,P35789,Q9ULW6,Q96BK5 47 3.69e-02 2242 8 4 0.500 0.002 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q9Y2T7,Q8IWA0,Q15061,Q96BK5 47 3.75e-02 6433 8 7 0.875 0.001 TF:M00724_0 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 0 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789,Q96BK5 47 3.78e-02 3440 8 5 0.625 0.001 TF:M04306_1 tf 1 Factor: DPRX; motif: NNGGATTANN; match class: 1 1 P22087,Q96RS0,P35789,Q9ULW6,Q96BK5 47 3.83e-02 62 8 1 0.125 0.016 TF:M02113_0 tf 1 Factor: OCA-B; motif: ATATGCAAATC; match class: 0 1 Q96RS0 47 3.83e-02 165 8 2 0.250 0.012 GO:0043414 BP 1 macromolecule methylation 1 P22087,Q96RS0 47 3.94e-02 8 8 1 0.125 0.125 GO:0040023 BP 1 establishment of nucleus localization 1 Q15061 47 3.94e-02 8 8 1 0.125 0.125 GO:0032196 BP 1 transposition 1 P35789 47 3.95e-02 64 8 1 0.125 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 Q9ULW6 47 3.98e-02 466 8 3 0.375 0.006 MI:hsa-miR-627 mi 1 MI:hsa-miR-627 1 Q9Y2T7,P22087,Q96BK5 47 4.10e-02 2314 8 4 0.500 0.002 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 Q96RS0,Q15061,P35789,Q9ULW6 47 4.13e-02 3058 8 6 0.750 0.002 GO:0010467 BP 1 gene expression 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,P35789 47 4.14e-02 67 8 1 0.125 0.015 TF:M00979_0 tf 1 Factor: Pax-6; motif: CTGACCTGGAACTM; match class: 0 1 Q8IWA0 47 4.25e-02 1328 8 3 0.375 0.002 TF:M04085_0 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 0 1 Q9Y2T7,Q96RS0,P35789 47 4.26e-02 69 8 1 0.125 0.014 TF:M06089_0 tf 1 Factor: ZNF26; motif: NAMTCAAGSGTA; match class: 0 1 Q96BK5 47 4.43e-02 9 8 1 0.125 0.111 GO:0043144 BP 1 snoRNA processing 1 P22087 47 4.45e-02 554 8 2 0.250 0.004 TF:M04323_0 tf 1 Factor: GBX2; motif: TAATTGNNCAATTA; match class: 0 1 Q15061,Q9ULW6 47 4.50e-02 73 8 1 0.125 0.014 TF:M03949_1 tf 1 Factor: TFCP2; motif: ACCGGTTNAAACYGGT; match class: 1 1 P35789 47 4.51e-02 1359 8 3 0.375 0.002 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q15061,P35789,Q9ULW6 47 4.56e-02 5003 8 6 0.750 0.001 TF:M04633_0 tf 1 Factor: TCF-4; motif: NCTTTGAWNN; match class: 0 1 Q8IWA0,Q96RS0,Q15061,P35789,Q9ULW6,Q96BK5 47 4.65e-02 4430 8 7 0.875 0.002 GO:0005634 CC 1 nucleus 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,Q9ULW6,Q96BK5 47 4.74e-02 184 8 2 0.250 0.011 GO:0032259 BP 1 methylation 1 P22087,Q96RS0 47 4.93e-02 10 8 1 0.125 0.100 GO:0016074 BP 1 snoRNA metabolic process 1 P22087 47 4.99e-02 1414 8 3 0.375 0.002 TF:M07067_1 tf 1 Factor: USF1; motif: NNNNGTCACGTGGN; match class: 1 1 Q9Y2T7,Q15061,Q96BK5 47 5.00e-02 505 8 3 0.375 0.006 MI:mmu-miR-743a mi 1 MI:mmu-miR-743a 1 Q8IWA0,Q96RS0,Q15061 47 5.00e-02 6 8 1 0.125 0.167 CORUM:1231 cor 1 FIB-associated protein complex 1 P22087 47 5.00e-02 3168 8 6 0.750 0.002 GO:0044428 CC 1 nuclear part 1 Q9Y2T7,P22087,Q8IWA0,Q96RS0,Q15061,Q96BK5 47 5.00e-02 200 8 3 0.375 0.015 REAC:72312 rea 1 rRNA processing 1 P22087,Q8IWA0,Q15061 47 5.00e-02 74 8 3 0.375 0.041 KEGG:03008 keg 1 Ribosome biogenesis in eukaryotes 1 P22087,Q8IWA0,Q15061 48 2.41e-03 5 3 1 0.333 0.200 REAC:3065676 rea 1 SUMO is conjugated to E1 (UBA2:SAE1) 1 Q9UBE0 48 3.38e-03 7 3 1 0.333 0.143 REAC:3065678 rea 1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 Q9UBE0 48 4.81e-03 455 3 2 0.667 0.004 MI:hsa-miR-646 mi 1 MI:hsa-miR-646 1 Q8WU10,Q9UBE0 48 4.83e-03 10 3 1 0.333 0.100 REAC:3215018 rea 1 Processing and activation of SUMO 1 Q9UBE0 48 4.98e-03 463 3 2 0.667 0.004 MI:hsa-miR-194 mi 1 MI:hsa-miR-194 1 Q8WU10,Q99988 48 5.23e-03 475 3 2 0.667 0.004 MI:hsa-miR-125a-5p mi 1 MI:hsa-miR-125a-5p 1 Q99988,Q9UBE0 48 6.84e-03 544 3 2 0.667 0.004 MI:hsa-miR-590-5p mi 1 MI:hsa-miR-590-5p 1 Q8WU10,Q99988 48 3.33e-02 2 3 1 0.333 0.500 CORUM:5756 cor 1 SUA1-UBA2 complex 1 Q9UBE0 48 3.87e-02 141 3 1 0.333 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 Q9UBE0 48 5.00e-02 3 3 1 0.333 0.333 CORUM:5755 cor 1 SUMO1-SUA1-UBA2 complex 1 Q9UBE0 48 5.00e-02 3 3 1 0.333 0.333 TF:M06772_0 tf 1 Factor: ZNF780B; motif: AWTAGGACGTCKTCGTARS; match class: 0 1 Q99988 48 5.00e-02 2 3 1 0.333 0.500 GO:0019948 MF 1 SUMO activating enzyme activity 1 Q9UBE0 48 5.00e-02 105 3 1 0.333 0.010 REAC:2990846 rea 1 SUMOylation 1 Q9UBE0 48 5.00e-02 2 3 1 0.333 0.500 GO:0031510 CC 1 SUMO activating enzyme complex 1 Q9UBE0 49 1.29e-03 402 2 2 1.000 0.005 MI:hsa-miR-411 mi 1 MI:hsa-miR-411 1 Q7Z4L5,Q14183 49 1.55e-03 441 2 2 1.000 0.005 MI:hsa-miR-147b mi 1 MI:hsa-miR-147b 1 Q7Z4L5,Q14183 49 4.18e-03 1 2 1 0.500 1.000 OMIM:613819 omi 1 SHORT-RIB THORACIC DYSPLASIA 4 WITH OR WITHOUT POLYDACTYLY; SRTD4;;ASPHYXIATING THORACIC DYSTROPHY 4; ATD4 1 Q7Z4L5 49 4.18e-03 1 2 1 0.500 1.000 OMIM:613820 omi 1 NEPHRONOPHTHISIS 12; NPHP12JOUBERT SYNDROME 11, INCLUDED; JBTS11, INCLUDED 1 Q7Z4L5 49 1.22e-02 9 2 1 0.500 0.111 HP:0008797 hp 1 Early ossification of capital femoral epiphyses 1 Q7Z4L5 49 1.22e-02 9 2 1 0.500 0.111 HP:0011315 hp 1 Unicoronal synostosis 1 Q7Z4L5 49 1.36e-02 10 2 1 0.500 0.100 HP:0004743 hp 1 Chronic tubulointerstitial nephritis 1 Q7Z4L5 49 1.36e-02 10 2 1 0.500 0.100 HP:0100866 hp 1 Short iliac bones 1 Q7Z4L5 49 1.49e-02 11 2 1 0.500 0.091 HP:0006644 hp 1 Thoracic dysplasia 1 Q7Z4L5 49 1.63e-02 12 2 1 0.500 0.083 HP:0006557 hp 1 Polycystic liver disease 1 Q7Z4L5 49 1.63e-02 12 2 1 0.500 0.083 HP:0009817 hp 1 Aplasia involving bones of the lower limbs 1 Q7Z4L5 49 1.63e-02 12 2 1 0.500 0.083 HP:0009556 hp 1 Absent tibia 1 Q7Z4L5 49 1.76e-02 13 2 1 0.500 0.077 HP:0005054 hp 1 Metaphyseal spurs 1 Q7Z4L5 49 1.76e-02 13 2 1 0.500 0.077 HP:0000888 hp 1 Horizontal ribs 1 Q7Z4L5 49 1.76e-02 13 2 1 0.500 0.077 HP:0010454 hp 1 Acetabular spurs 1 Q7Z4L5 49 1.76e-02 13 2 1 0.500 0.077 HP:0009107 hp 1 Abnormal ossification involving the femoral head and neck 1 Q7Z4L5 49 2.17e-02 16 2 1 0.500 0.062 HP:0002908 hp 1 Conjugated hyperbilirubinemia 1 Q7Z4L5 49 2.31e-02 17 2 1 0.500 0.059 HP:0010444 hp 1 Pulmonary insufficiency 1 Q7Z4L5 49 2.44e-02 18 2 1 0.500 0.056 HP:0003027 hp 1 Mesomelia 1 Q7Z4L5 49 2.44e-02 18 2 1 0.500 0.056 HP:0003259 hp 1 Elevated serum creatinine 1 Q7Z4L5 49 2.44e-02 18 2 1 0.500 0.056 HP:0012100 hp 1 Abnormal circulating creatinine level 1 Q7Z4L5 49 2.71e-02 20 2 1 0.500 0.050 HP:0009825 hp 1 Aplasia involving bones of the extremities 1 Q7Z4L5 49 2.80e-02 8 2 1 0.500 0.125 GO:0030991 CC 1 intraciliary transport particle A 1 Q7Z4L5 49 2.80e-02 8 2 1 0.500 0.125 GO:0035721 BP 1 intraciliary retrograde transport 1 Q7Z4L5 49 2.85e-02 21 2 1 0.500 0.048 HP:0008839 hp 1 Hypoplastic pelvis 1 Q7Z4L5 49 2.85e-02 21 2 1 0.500 0.048 HP:0005772 hp 1 Aplasia/Hypoplasia of the tibia 1 Q7Z4L5 49 2.85e-02 21 2 1 0.500 0.048 HP:0000895 hp 1 Lateral clavicle hook 1 Q7Z4L5 49 2.85e-02 21 2 1 0.500 0.048 HP:0004440 hp 1 Coronal craniosynostosis 1 Q7Z4L5 49 2.85e-02 21 2 1 0.500 0.048 HP:0003180 hp 1 Flat acetabular roof 1 Q7Z4L5 49 2.98e-02 22 2 1 0.500 0.045 HP:0000105 hp 1 Enlarged kidneys 1 Q7Z4L5 49 3.12e-02 23 2 1 0.500 0.043 HP:0010297 hp 1 Bifid tongue 1 Q7Z4L5 49 3.52e-02 26 2 1 0.500 0.038 HP:0002866 hp 1 Hypoplastic iliac wing 1 Q7Z4L5 49 3.52e-02 26 2 1 0.500 0.038 HP:0010582 hp 1 Irregular epiphyses 1 Q7Z4L5 49 3.66e-02 27 2 1 0.500 0.037 HP:0100732 hp 1 Pancreatic fibrosis 1 Q7Z4L5 49 3.79e-02 28 2 1 0.500 0.036 HP:0001169 hp 1 Broad palm 1 Q7Z4L5 49 3.92e-02 29 2 1 0.500 0.034 HP:0000833 hp 1 Glucose intolerance 1 Q7Z4L5 49 3.92e-02 29 2 1 0.500 0.034 HP:0003025 hp 1 Metaphyseal irregularity 1 Q7Z4L5 49 4.19e-02 31 2 1 0.500 0.032 HP:0003038 hp 1 Fibular hypoplasia 1 Q7Z4L5 49 4.46e-02 33 2 1 0.500 0.030 HP:0010230 hp 1 Cone-shaped epiphyses of the phalanges of the hand 1 Q7Z4L5 49 4.58e-02 11 2 1 0.500 0.091 OMIM:256100 omi 1 Nephronophthisis 1 Q7Z4L5 49 4.60e-02 34 2 1 0.500 0.029 HP:0001737 hp 1 Pancreatic cysts 1 Q7Z4L5 49 4.60e-02 34 2 1 0.500 0.029 HP:0001952 hp 1 Abnormal glucose tolerance 1 Q7Z4L5 49 4.60e-02 34 2 1 0.500 0.029 HP:0006492 hp 1 Aplasia/Hypoplasia of the fibula 1 Q7Z4L5 49 4.73e-02 35 2 1 0.500 0.029 HP:0001970 hp 1 Tubulointerstitial nephritis 1 Q7Z4L5 49 4.87e-02 36 2 1 0.500 0.028 HP:0000695 hp 1 Natal tooth 1 Q7Z4L5 49 5.00e-02 37 2 1 0.500 0.027 HP:0000308 hp 1 Microretrognathia 1 Q7Z4L5 49 5.00e-02 348 2 2 1.000 0.006 TF:M02242_0 tf 1 Factor: CTCF; motif: YNRCCASYAGRKGGCRSYN; match class: 0 1 Q7Z4L5,Q14183 49 5.00e-02 37 2 1 0.500 0.027 HP:0001408 hp 1 Bile duct proliferation 1 Q7Z4L5 49 5.00e-02 12 2 1 0.500 0.083 OMIM:208500 omi 1 Asphyxiating Thoracic Dysplasia 1 Q7Z4L5 49 5.00e-02 37 2 1 0.500 0.027 HP:0001830 hp 1 Postaxial foot polydactyly 1 Q7Z4L5 49 5.00e-02 39 2 1 0.500 0.026 REAC:5620924 rea 1 Intraflagellar transport 1 Q7Z4L5 49 5.00e-02 574 2 2 1.000 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 Q7Z4L5,Q14183 50 3.73e-07 2 5 2 0.400 1.000 GO:0046166 BP 1 glyceraldehyde-3-phosphate biosynthetic process 1 P60174,P29401 50 2.97e-06 58 5 3 0.600 0.052 GO:0046364 BP 1 monosaccharide biosynthetic process 1 P06733,P60174,P29401 50 9.83e-06 86 5 3 0.600 0.035 GO:0046496 BP 1 nicotinamide nucleotide metabolic process 1 P06733,P60174,P29401 50 9.83e-06 86 5 3 0.600 0.035 GO:0019362 BP 1 pyridine nucleotide metabolic process 1 P06733,P60174,P29401 50 1.04e-05 8 5 2 0.400 0.250 GO:0046184 BP 1 aldehyde biosynthetic process 1 P60174,P29401 50 1.29e-05 94 5 3 0.600 0.032 GO:0006733 BP 1 oxidoreduction coenzyme metabolic process 1 P06733,P60174,P29401 50 1.41e-05 97 5 3 0.600 0.031 GO:0072524 BP 1 pyridine-containing compound metabolic process 1 P06733,P60174,P29401 50 2.36e-05 115 5 3 0.600 0.026 GO:0016051 BP 1 carbohydrate biosynthetic process 1 P06733,P60174,P29401 50 4.68e-05 69 5 3 0.600 0.043 KEGG:01230 keg 1 Biosynthesis of amino acids 1 P06733,P60174,P29401 50 7.07e-05 20 5 2 0.400 0.100 GO:0019682 BP 1 glyceraldehyde-3-phosphate metabolic process 1 P60174,P29401 50 7.64e-05 170 5 3 0.600 0.018 GO:0005996 BP 1 monosaccharide metabolic process 1 P06733,P60174,P29401 50 1.21e-04 26 5 2 0.400 0.077 GO:0061615 BP 1 glycolytic process through fructose-6-phosphate 1 P06733,P60174 50 1.21e-04 26 5 2 0.400 0.077 GO:0006735 BP 1 NADH regeneration 1 P06733,P60174 50 1.21e-04 26 5 2 0.400 0.077 GO:0061718 BP 1 glucose catabolic process to pyruvate 1 P06733,P60174 50 1.21e-04 26 5 2 0.400 0.077 GO:0061620 BP 1 glycolytic process through glucose-6-phosphate 1 P06733,P60174 50 1.21e-04 26 5 2 0.400 0.077 GO:0061621 BP 1 canonical glycolysis 1 P06733,P60174 50 1.40e-04 28 5 2 0.400 0.071 GO:0006007 BP 1 glucose catabolic process 1 P06733,P60174 50 1.52e-04 214 5 3 0.600 0.014 GO:0006732 BP 1 coenzyme metabolic process 1 P06733,P60174,P29401 50 1.62e-04 30 5 2 0.400 0.067 GO:0006734 BP 1 NADH metabolic process 1 P06733,P60174 50 1.75e-04 107 5 3 0.600 0.028 KEGG:01200 keg 1 Carbon metabolism 1 P06733,P60174,P29401 50 1.88e-04 32 5 2 0.400 0.062 REAC:70171 rea 1 Glycolysis 1 P06733,P60174 50 1.88e-04 32 5 2 0.400 0.062 REAC:70263 rea 1 Gluconeogenesis 1 P06733,P60174 50 2.94e-04 267 5 3 0.600 0.011 GO:0051186 BP 1 cofactor metabolic process 1 P06733,P60174,P29401 50 3.19e-04 42 5 2 0.400 0.048 GO:0019674 BP 1 NAD metabolic process 1 P06733,P60174 50 3.28e-04 277 5 3 0.600 0.011 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 P06733,P60174,P29401 50 3.50e-04 44 5 2 0.400 0.045 GO:0019320 BP 1 hexose catabolic process 1 P06733,P60174 50 3.71e-04 246 5 3 0.600 0.012 REAC:71387 rea 1 Metabolism of carbohydrates 1 P06733,P60174,P29401 50 4.33e-04 304 5 3 0.600 0.010 GO:0044283 BP 1 small molecule biosynthetic process 1 P06733,P60174,P29401 50 4.35e-04 49 5 2 0.400 0.041 GO:0006096 BP 1 glycolytic process 1 P06733,P60174 50 4.53e-04 50 5 2 0.400 0.040 GO:0006757 BP 1 ATP generation from ADP 1 P06733,P60174 50 4.72e-04 51 5 2 0.400 0.039 GO:0006094 BP 1 gluconeogenesis 1 P06733,P60174 50 4.91e-04 52 5 2 0.400 0.038 GO:0046365 BP 1 monosaccharide catabolic process 1 P06733,P60174 50 4.91e-04 52 5 2 0.400 0.038 GO:0046031 BP 1 ADP metabolic process 1 P06733,P60174 50 4.99e-04 319 5 3 0.600 0.009 GO:0019693 BP 1 ribose phosphate metabolic process 1 P06733,P60174,P29401 50 5.23e-04 324 5 3 0.600 0.009 GO:0005975 BP 1 carbohydrate metabolic process 1 P06733,P60174,P29401 50 5.29e-04 54 5 2 0.400 0.037 GO:0019319 BP 1 hexose biosynthetic process 1 P06733,P60174 50 5.29e-04 54 5 2 0.400 0.037 GO:0009179 BP 1 purine ribonucleoside diphosphate metabolic process 1 P06733,P60174 50 5.29e-04 54 5 2 0.400 0.037 GO:0009135 BP 1 purine nucleoside diphosphate metabolic process 1 P06733,P60174 50 5.69e-04 56 5 2 0.400 0.036 GO:0006165 BP 1 nucleoside diphosphate phosphorylation 1 P06733,P60174 50 5.69e-04 56 5 2 0.400 0.036 GO:0009185 BP 1 ribonucleoside diphosphate metabolic process 1 P06733,P60174 50 5.90e-04 57 5 2 0.400 0.035 GO:0046939 BP 1 nucleotide phosphorylation 1 P06733,P60174 50 6.98e-04 62 5 2 0.400 0.032 GO:0009132 BP 1 nucleoside diphosphate metabolic process 1 P06733,P60174 50 8.91e-04 388 5 3 0.600 0.008 GO:0009117 BP 1 nucleotide metabolic process 1 P06733,P60174,P29401 50 9.16e-04 71 5 2 0.400 0.028 GO:0006081 BP 1 cellular aldehyde metabolic process 1 P60174,P29401 50 9.61e-04 398 5 3 0.600 0.008 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P06733,P60174,P29401 50 1.05e-03 76 5 2 0.400 0.026 GO:0006090 BP 1 pyruvate metabolic process 1 P06733,P60174 50 1.08e-03 1 5 1 0.200 1.000 GO:0019563 BP 1 glycerol catabolic process 1 P60174 50 1.08e-03 1 5 1 0.200 1.000 GO:0004802 MF 1 transketolase activity 1 P29401 50 1.08e-03 1 5 1 0.200 1.000 GO:0004807 MF 1 triose-phosphate isomerase activity 1 P60174 50 1.10e-03 77 5 2 0.400 0.026 REAC:70326 rea 1 Glucose metabolism 1 P06733,P60174 50 1.38e-03 450 5 3 0.600 0.007 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P06733,P60174,P29401 50 1.38e-03 2 5 1 0.200 0.500 REAC:163754 rea 1 Insulin effects increased synthesis of Xylulose-5-Phosphate 1 P29401 50 1.71e-03 97 5 2 0.400 0.021 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 P06733,P60174 50 1.89e-03 102 5 2 0.400 0.020 GO:0016052 BP 1 carbohydrate catabolic process 1 P06733,P60174 50 2.15e-03 2 5 1 0.200 0.500 GO:0019405 BP 1 alditol catabolic process 1 P60174 50 2.15e-03 2 5 1 0.200 0.500 GO:0016744 MF 1 transferase activity, transferring aldehyde or ketonic groups 1 P29401 50 2.15e-03 2 5 1 0.200 0.500 GO:0005999 BP 1 xylulose biosynthetic process 1 P29401 50 2.20e-03 110 5 2 0.400 0.018 GO:0006006 BP 1 glucose metabolic process 1 P06733,P60174 50 2.84e-03 62 5 2 0.400 0.032 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P06733,P60174 50 3.23e-03 3 5 1 0.200 0.333 GO:0004719 MF 1 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 1 P22061 50 3.23e-03 3 5 1 0.200 0.333 GO:0004634 MF 1 phosphopyruvate hydratase activity 1 P06733 50 3.23e-03 3 5 1 0.200 0.333 GO:0019322 BP 1 pentose biosynthetic process 1 P29401 50 3.23e-03 3 5 1 0.200 0.333 GO:0009052 BP 1 pentose-phosphate shunt, non-oxidative branch 1 P29401 50 3.40e-03 137 5 2 0.400 0.015 GO:0019318 BP 1 hexose metabolic process 1 P06733,P60174 50 3.46e-03 5 5 1 0.200 0.200 REAC:5676934 rea 1 Protein repair 1 P22061 50 4.30e-03 4 5 1 0.200 0.250 GO:0005997 BP 1 xylulose metabolic process 1 P29401 50 4.51e-03 674 5 3 0.600 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 P06733,P60174,P29401 50 5.70e-03 178 5 2 0.400 0.011 GO:0046034 BP 1 ATP metabolic process 1 P06733,P60174 50 6.21e-03 9 5 1 0.200 0.111 REAC:71336 rea 1 Pentose phosphate pathway (hexose monophosphate shunt) 1 P29401 50 6.42e-03 189 5 2 0.400 0.011 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P06733,P60174 50 6.45e-03 6 5 1 0.200 0.167 GO:0010340 MF 1 carboxyl-O-methyltransferase activity 1 P22061 50 6.45e-03 6 5 1 0.200 0.167 GO:0051998 MF 1 protein carboxyl O-methyltransferase activity 1 P22061 50 6.45e-03 6 5 1 0.200 0.167 GO:0030091 BP 1 protein repair 1 P22061 50 6.48e-03 190 5 2 0.400 0.011 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P06733,P60174 50 6.69e-03 193 5 2 0.400 0.010 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P06733,P60174 50 7.25e-03 201 5 2 0.400 0.010 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P06733,P60174 50 7.25e-03 201 5 2 0.400 0.010 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P06733,P60174 50 7.37e-03 798 5 3 0.600 0.004 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P06733,P60174,P29401 50 7.39e-03 203 5 2 0.400 0.010 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P06733,P60174 50 7.60e-03 206 5 2 0.400 0.010 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P06733,P60174 50 7.90e-03 210 5 2 0.400 0.010 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P06733,P60174 50 8.60e-03 8 5 1 0.200 0.125 GO:0006071 BP 1 glycerol metabolic process 1 P60174 50 8.60e-03 8 5 1 0.200 0.125 GO:0019321 BP 1 pentose metabolic process 1 P29401 50 8.87e-03 851 5 3 0.600 0.004 GO:0044711 BP 1 single-organism biosynthetic process 1 P06733,P60174,P29401 50 9.67e-03 9 5 1 0.200 0.111 GO:0019400 BP 1 alditol metabolic process 1 P60174 50 1.03e-02 240 5 2 0.400 0.008 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P06733,P60174 50 1.05e-02 243 5 2 0.400 0.008 GO:0042278 BP 1 purine nucleoside metabolic process 1 P06733,P60174 50 1.07e-02 10 5 1 0.200 0.100 GO:0016861 MF 1 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1 P60174 50 1.08e-02 246 5 2 0.400 0.008 GO:0044282 BP 1 small molecule catabolic process 1 P06733,P60174 50 1.12e-02 251 5 2 0.400 0.008 GO:0009119 BP 1 ribonucleoside metabolic process 1 P06733,P60174 50 1.17e-02 257 5 2 0.400 0.008 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P06733,P60174 50 1.18e-02 11 5 1 0.200 0.091 GO:0046174 BP 1 polyol catabolic process 1 P60174 50 1.30e-02 271 5 2 0.400 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 P06733,P22061 50 1.34e-02 275 5 2 0.400 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 P06733,P22061 50 1.36e-02 277 5 2 0.400 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 P06733,P22061 50 1.37e-02 2194 5 4 0.800 0.002 GO:0070062 CC 1 extracellular exosome 1 P06733,P60174,P22061,P29401 50 1.40e-02 281 5 2 0.400 0.007 GO:0009116 BP 1 nucleoside metabolic process 1 P06733,P60174 50 1.40e-02 2205 5 4 0.800 0.002 GO:1903561 CC 1 extracellular vesicle 1 P06733,P60174,P22061,P29401 50 1.40e-02 2205 5 4 0.800 0.002 GO:0043230 CC 1 extracellular organelle 1 P06733,P60174,P22061,P29401 50 1.41e-02 282 5 2 0.400 0.007 GO:0045296 MF 1 cadherin binding 1 P06733,P22061 50 1.53e-02 294 5 2 0.400 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 P06733,P22061 50 1.58e-02 299 5 2 0.400 0.007 GO:1901657 BP 1 glycosyl compound metabolic process 1 P06733,P60174 50 1.61e-02 15 5 1 0.200 0.067 GO:0006098 BP 1 pentose-phosphate shunt 1 P29401 50 1.62e-02 303 5 2 0.400 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P06733,P60174 50 1.66e-02 307 5 2 0.400 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 P06733,P60174 50 1.72e-02 16 5 1 0.200 0.062 GO:0008171 MF 1 O-methyltransferase activity 1 P22061 50 1.82e-02 17 5 1 0.200 0.059 GO:0051156 BP 1 glucose 6-phosphate metabolic process 1 P29401 50 1.85e-02 324 5 2 0.400 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 P06733,P60174 50 1.96e-02 334 5 2 0.400 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 P60174,P29401 50 2.14e-02 350 5 2 0.400 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 P06733,P60174 50 2.18e-02 353 5 2 0.400 0.006 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P06733,P60174 50 2.25e-02 21 5 1 0.200 0.048 GO:0046164 BP 1 alcohol catabolic process 1 P60174 50 2.28e-02 364 5 3 0.600 0.008 MI:hsa-miR-497* mi 1 MI:hsa-miR-497* 1 P06733,P60174,P22061 50 2.38e-02 369 5 2 0.400 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 P06733,P22061 50 2.45e-02 375 5 2 0.400 0.005 GO:0055114 BP 1 oxidation-reduction process 1 P06733,P60174 50 2.57e-02 24 5 1 0.200 0.042 GO:0006739 BP 1 NADP metabolic process 1 P29401 50 2.73e-02 2627 5 4 0.800 0.002 GO:0044421 CC 1 extracellular region part 1 P06733,P60174,P22061,P29401 50 2.79e-02 26 5 1 0.200 0.038 GO:1901616 BP 1 organic hydroxy compound catabolic process 1 P60174 50 2.89e-02 27 5 1 0.200 0.037 GO:0044275 BP 1 cellular carbohydrate catabolic process 1 P60174 50 3.05e-02 420 5 2 0.400 0.005 GO:0005911 CC 1 cell-cell junction 1 P06733,P22061 50 3.05e-02 2707 5 4 0.800 0.001 GO:0005829 CC 1 cytosol 1 P06733,P60174,P22061,P29401 50 3.19e-02 1333 5 3 0.600 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P06733,P60174,P29401 50 3.21e-02 2743 5 4 0.800 0.001 GO:0005576 CC 1 extracellular region 1 P06733,P60174,P22061,P29401 50 3.44e-02 2795 5 4 0.800 0.001 GO:0031982 CC 1 vesicle 1 P06733,P60174,P22061,P29401 50 3.73e-02 466 5 2 0.400 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P60174,P29401 50 3.98e-02 730 5 2 0.400 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 P06733,P29401 50 4.02e-02 441 5 3 0.600 0.007 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 P60174,P22061,A8MPS7 50 4.17e-02 39 5 1 0.200 0.026 GO:0016836 MF 1 hydro-lyase activity 1 P06733 50 4.49e-02 42 5 1 0.200 0.024 GO:0016860 MF 1 intramolecular oxidoreductase activity 1 P60174 50 4.51e-02 781 5 2 0.400 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P06733,P29401 50 4.57e-02 786 5 2 0.400 0.003 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 P06733,P60174 50 4.62e-02 1985 5 3 0.600 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 P06733,P60174,P29401 50 4.70e-02 798 5 2 0.400 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P06733,P29401 50 5.00e-02 1 5 1 0.200 1.000 OMIM:615512 omi 1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY; TPID 1 P60174 50 5.00e-02 1 5 1 0.200 1.000 TF:M04457_0 tf 1 Factor: ESRRA; motif: AAGGTCATNCAAGGTCA; match class: 0 1 P29401 50 5.00e-02 475 5 3 0.600 0.006 MI:hsa-miR-425 mi 1 MI:hsa-miR-425 1 P06733,P60174,P22061 50 5.00e-02 8 5 1 0.200 0.125 HP:0001082 hp 1 Cholecystitis 1 P60174 50 5.00e-02 26 5 1 0.200 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 P29401 50 5.00e-02 8 5 1 0.200 0.125 HP:0012438 hp 1 Abnormal gallbladder physiology 1 P60174 50 5.00e-02 1565 5 3 0.600 0.002 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P06733,P60174,P29401 51 3.57e-03 1 2 1 0.500 1.000 GO:0035508 BP 1 positive regulation of myosin-light-chain-phosphatase activity 1 O14974 51 1.05e-02 67 2 1 0.500 0.015 TF:M06141_0 tf 1 Factor: ZNF708; motif: NGKGGAAAAGGW; match class: 0 1 O14974 51 1.36e-02 87 2 1 0.500 0.011 TF:M06727_1 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 1 1 Q9BWX1 51 1.46e-02 93 2 1 0.500 0.011 TF:M01235_0 tf 1 Factor: ipf1; motif: NVSTAATTAC; match class: 0 1 O14974 51 1.50e-02 96 2 1 0.500 0.010 TF:M07120_0 tf 1 Factor: Oct-2; motif: NNNATTTGCATRT; match class: 0 1 O14974 51 1.52e-02 1569 2 2 1.000 0.001 TF:M01233_0 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 0 1 Q9BWX1,O14974 51 1.63e-02 104 2 1 0.500 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 O14974 51 1.75e-02 112 2 1 0.500 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 Q9BWX1 51 1.80e-02 115 2 1 0.500 0.009 TF:M01588_1 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 1 Q9BWX1 51 1.81e-02 17 2 1 0.500 0.059 REAC:5627117 rea 1 RHO GTPases Activate ROCKs 1 O14974 51 2.13e-02 1856 2 2 1.000 0.001 TF:M04425_0 tf 1 Factor: PDX1; motif: NYAATTAN; match class: 0 1 Q9BWX1,O14974 51 2.13e-02 1856 2 2 1.000 0.001 TF:M04316_0 tf 1 Factor: EN1; motif: NYAATTAN; match class: 0 1 Q9BWX1,O14974 51 2.13e-02 20 2 1 0.500 0.050 REAC:5627123 rea 1 RHO GTPases activate PAKs 1 O14974 51 2.14e-02 137 2 1 0.500 0.007 TF:M04352_1 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 1 1 O14974 51 2.14e-02 137 2 1 0.500 0.007 TF:M04339_1 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 1 1 O14974 51 2.14e-02 6 2 1 0.500 0.167 GO:0035507 BP 1 regulation of myosin-light-chain-phosphatase activity 1 O14974 51 2.14e-02 6 2 1 0.500 0.167 GO:0032516 BP 1 positive regulation of phosphoprotein phosphatase activity 1 O14974 51 2.31e-02 1933 2 2 1.000 0.001 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 Q9BWX1,O14974 51 2.34e-02 150 2 1 0.500 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 Q9BWX1 51 2.47e-02 158 2 1 0.500 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 O14974 51 2.50e-02 7 2 1 0.500 0.143 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 O14974 51 2.50e-02 7 2 1 0.500 0.143 GO:1903140 BP 1 regulation of establishment of endothelial barrier 1 O14974 51 2.50e-02 7 2 1 0.500 0.143 GO:1901550 BP 1 regulation of endothelial cell development 1 O14974 51 2.51e-02 161 2 1 0.500 0.006 TF:M07361_1 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 1 1 Q9BWX1 51 2.62e-02 2062 2 2 1.000 0.001 TF:M07052_0 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 0 1 Q9BWX1,O14974 51 2.82e-02 181 2 1 0.500 0.006 TF:M07227_0 tf 1 Factor: SRF; motif: NNTKNCCAWATAWGGNAA; match class: 0 1 O14974 51 2.83e-02 2140 2 2 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 Q9BWX1,O14974 51 2.89e-02 2166 2 2 1.000 0.001 TF:M03891_1 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 1 1 Q9BWX1,O14974 51 2.96e-02 190 2 1 0.500 0.005 TF:M01592_1 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 1 Q9BWX1 51 3.21e-02 9 2 1 0.500 0.111 GO:0010922 BP 1 positive regulation of phosphatase activity 1 O14974 51 3.21e-02 9 2 1 0.500 0.111 GO:0045601 BP 1 regulation of endothelial cell differentiation 1 O14974 51 3.24e-02 208 2 1 0.500 0.005 TF:M06154_0 tf 1 Factor: ZNF132; motif: NTTRGAAATGTTYM; match class: 0 1 O14974 51 3.33e-02 85 2 1 0.500 0.012 KEGG:04270 keg 1 Vascular smooth muscle contraction 1 O14974 51 3.33e-02 2 2 1 0.500 0.500 CORUM:817 cor 1 MRIP-MBS complex 1 O14974 51 3.38e-02 217 2 1 0.500 0.005 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 O14974 51 3.38e-02 217 2 1 0.500 0.005 TF:M00141_1 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 1 1 Q9BWX1 51 3.47e-02 474 2 2 1.000 0.004 GO:0005815 CC 1 microtubule organizing center 1 Q9BWX1,O14974 51 3.58e-02 230 2 1 0.500 0.004 TF:M04364_0 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 0 1 O14974 51 3.73e-02 2459 2 2 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q9BWX1,O14974 51 3.82e-02 2487 2 2 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q9BWX1,O14974 51 3.82e-02 2487 2 2 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q9BWX1,O14974 51 3.82e-02 2487 2 2 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q9BWX1,O14974 51 3.91e-02 251 2 1 0.500 0.004 TF:M01066_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN; match class: 0 1 O14974 51 3.93e-02 11 2 1 0.500 0.091 GO:0031672 CC 1 A band 1 O14974 51 3.94e-02 2528 2 2 1.000 0.001 TF:M02117_0 tf 1 Factor: STAT4; motif: TTMNNRGAAA; match class: 0 1 Q9BWX1,O14974 51 4.03e-02 103 2 1 0.500 0.010 KEGG:04611 keg 1 Platelet activation 1 O14974 51 4.06e-02 2565 2 2 1.000 0.001 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 Q9BWX1,O14974 51 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 O14974 51 4.17e-02 268 2 1 0.500 0.004 TF:M04362_0 tf 1 Factor: HOXD12; motif: RGTCGTAAAAN; match class: 0 1 O14974 51 4.23e-02 2617 2 2 1.000 0.001 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 Q9BWX1,O14974 51 4.26e-02 2626 2 2 1.000 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q9BWX1,O14974 51 4.34e-02 279 2 1 0.500 0.004 TF:M04290_0 tf 1 Factor: BARX1; motif: CNATTAAAWANCNATTA; match class: 0 1 O14974 51 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 Q9BWX1,O14974 51 4.49e-02 289 2 1 0.500 0.003 TF:M06379_0 tf 1 Factor: ZNF770; motif: NWGGGGCGAG; match class: 0 1 Q9BWX1 51 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 O14974 51 4.59e-02 2727 2 2 1.000 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 Q9BWX1,O14974 51 4.60e-02 296 2 1 0.500 0.003 TF:M07080_0 tf 1 Factor: C/EBPbeta; motif: KATTGCAYMAY; match class: 0 1 O14974 51 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q9BWX1 51 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-877* mi 1 MI:hsa-miR-877* 1 Q9BWX1 51 4.90e-02 278 2 1 0.500 0.004 MI:hsa-miR-550* mi 1 MI:hsa-miR-550* 1 Q9BWX1 51 4.98e-02 321 2 1 0.500 0.003 TF:M04342_0 tf 1 Factor: HOXA13; motif: NCTCGTAAAAN; match class: 0 1 O14974 51 5.00e-02 3 2 1 0.500 0.333 CORUM:815 cor 1 MRIP-MBS-RHOA complex 1 O14974 51 5.00e-02 47 2 1 0.500 0.021 REAC:5625740 rea 1 RHO GTPases activate PKNs 1 O14974 51 5.00e-02 14 2 1 0.500 0.071 GO:0071889 MF 1 14-3-3 protein binding 1 O14974 52 1.44e-05 1813 7 7 1.000 0.004 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 7.03e-05 2274 7 7 1.000 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 7.85e-05 2310 7 7 1.000 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.22e-04 11 7 2 0.286 0.182 GO:0001533 CC 1 cornified envelope 1 P07476,Q92817 52 2.02e-04 14 7 2 0.286 0.143 GO:0018149 BP 1 peptide cross-linking 1 P07476,Q92817 52 3.06e-04 1659 7 6 0.857 0.004 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 52 8.44e-04 1974 7 6 0.857 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 52 8.53e-04 3247 7 7 1.000 0.002 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.03e-03 3334 7 7 1.000 0.002 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.05e-03 3344 7 7 1.000 0.002 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.05e-03 3344 7 7 1.000 0.002 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.07e-03 3355 7 7 1.000 0.002 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.09e-03 3361 7 7 1.000 0.002 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.10e-03 3368 7 7 1.000 0.002 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.11e-03 3370 7 7 1.000 0.002 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.13e-03 3379 7 7 1.000 0.002 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.14e-03 3386 7 7 1.000 0.002 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.14e-03 3386 7 7 1.000 0.002 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.14e-03 3386 7 7 1.000 0.002 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.15e-03 3390 7 7 1.000 0.002 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.19e-03 3403 7 7 1.000 0.002 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.19e-03 3405 7 7 1.000 0.002 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.19e-03 3407 7 7 1.000 0.002 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.19e-03 3407 7 7 1.000 0.002 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.21e-03 3412 7 7 1.000 0.002 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.21e-03 3413 7 7 1.000 0.002 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.21e-03 3415 7 7 1.000 0.002 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.22e-03 3416 7 7 1.000 0.002 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.22e-03 3416 7 7 1.000 0.002 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.22e-03 3416 7 7 1.000 0.002 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.22e-03 3418 7 7 1.000 0.002 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3420 7 7 1.000 0.002 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3421 7 7 1.000 0.002 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3422 7 7 1.000 0.002 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3422 7 7 1.000 0.002 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3423 7 7 1.000 0.002 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.23e-03 3423 7 7 1.000 0.002 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.24e-03 3424 7 7 1.000 0.002 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.24e-03 3426 7 7 1.000 0.002 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.24e-03 3426 7 7 1.000 0.002 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.25e-03 3428 7 7 1.000 0.002 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.25e-03 3429 7 7 1.000 0.002 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.25e-03 3429 7 7 1.000 0.002 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.25e-03 3429 7 7 1.000 0.002 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.25e-03 3430 7 7 1.000 0.002 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3431 7 7 1.000 0.002 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3432 7 7 1.000 0.002 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3433 7 7 1.000 0.002 HPA:032010_10 hpa 1 salivary gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3433 7 7 1.000 0.002 HPA:007030_10 hpa 1 cerebral cortex; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3433 7 7 1.000 0.002 HPA:018020_10 hpa 1 hippocampus; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:037010_10 hpa 1 small intestine; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:030010_10 hpa 1 prostate; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:011020_10 hpa 1 endometrium 1; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:038010_10 hpa 1 smooth muscle; smooth muscle cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:021020_10 hpa 1 liver; hepatocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:044010_10 hpa 1 testis; Leydig cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:007020_10 hpa 1 cerebral cortex; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.26e-03 3434 7 7 1.000 0.002 HPA:022010_10 hpa 1 lung; macrophages[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:044020_10 hpa 1 testis; cells in seminiferous ducts[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:027010_10 hpa 1 pancreas; exocrine glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:029020_10 hpa 1 placenta; trophoblastic cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:015010_10 hpa 1 fallopian tube; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:045010_10 hpa 1 thyroid gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:017010_10 hpa 1 heart muscle; myocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:022020_10 hpa 1 lung; pneumocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:019020_10 hpa 1 kidney; cells in tubules[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:041010_10 hpa 1 spleen; cells in red pulp[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.27e-03 3435 7 7 1.000 0.002 HPA:010010_10 hpa 1 duodenum; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 1.31e-03 2130 7 6 0.857 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 52 1.58e-03 2200 7 6 0.857 0.003 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P19971,Q14134,P80188,P07476,P06702,Q92817 52 1.65e-03 2215 7 6 0.857 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 52 1.90e-03 42 7 2 0.286 0.048 GO:0030216 BP 1 keratinocyte differentiation 1 P07476,Q92817 52 1.90e-03 2271 7 6 0.857 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 52 2.85e-03 2435 7 6 0.857 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P80188,P07476,Q92817 52 2.96e-03 271 7 3 0.429 0.011 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 O60437,Q14134,Q92817 52 3.09e-03 275 7 3 0.429 0.011 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 O60437,Q14134,Q92817 52 3.15e-03 277 7 3 0.429 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 O60437,Q14134,Q92817 52 3.32e-03 282 7 3 0.429 0.011 GO:0045296 MF 1 cadherin binding 1 O60437,Q14134,Q92817 52 3.38e-03 56 7 2 0.286 0.036 GO:0046916 BP 1 cellular transition metal ion homeostasis 1 P80188,P06702 52 3.63e-03 58 7 2 0.286 0.034 GO:0009913 BP 1 epidermal cell differentiation 1 P07476,Q92817 52 3.73e-03 338 7 3 0.429 0.009 HPA:041010_13 hpa 1 spleen; cells in red pulp[Supportive,High] 1 P19971,P80188,P06702 52 3.76e-03 294 7 3 0.429 0.010 GO:0005913 CC 1 cell-cell adherens junction 1 O60437,Q14134,Q92817 52 3.92e-03 2574 7 6 0.857 0.002 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 O60437,Q14134,P80188,P07476,P06702,Q92817 52 4.29e-03 1 7 1 0.143 1.000 GO:0018153 BP 1 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine 1 P07476 52 4.29e-03 1 7 1 0.143 1.000 GO:0015891 BP 1 siderophore transport 1 P80188 52 4.29e-03 1 7 1 0.143 1.000 GO:0018262 BP 1 isopeptide cross-linking 1 P07476 52 4.29e-03 1 7 1 0.143 1.000 GO:0015688 BP 1 iron chelate transport 1 P80188 52 4.42e-03 64 7 2 0.286 0.031 GO:0055076 BP 1 transition metal ion homeostasis 1 P80188,P06702 52 6.55e-03 78 7 2 0.286 0.026 GO:0043588 BP 1 skin development 1 P07476,Q92817 52 6.88e-03 2839 7 6 0.857 0.002 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,Q92817 52 7.30e-03 369 7 3 0.429 0.008 GO:0050839 MF 1 cell adhesion molecule binding 1 O60437,Q14134,Q92817 52 7.34e-03 1782 7 5 0.714 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P19971,O60437,Q14134,P07476,P06702 52 7.59e-03 84 7 2 0.286 0.024 GO:0045111 CC 1 intermediate filament cytoskeleton 1 Q14134,Q92817 52 7.98e-03 2914 7 6 0.857 0.002 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,Q92817 52 8.06e-03 1818 7 5 0.714 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702,Q92817 52 8.57e-03 2 7 1 0.143 0.500 GO:0070488 BP 1 neutrophil aggregation 1 P06702 52 8.57e-03 2 7 1 0.143 0.500 GO:0035606 BP 1 peptidyl-cysteine S-trans-nitrosylation 1 P06702 52 1.02e-02 414 7 3 0.429 0.007 GO:0005198 MF 1 structural molecule activity 1 O60437,P07476,Q92817 52 1.03e-02 3045 7 6 0.857 0.002 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 P19971,O60437,Q14134,P80188,P07476,Q92817 52 1.06e-02 420 7 3 0.429 0.007 GO:0005911 CC 1 cell-cell junction 1 O60437,Q14134,Q92817 52 1.09e-02 101 7 2 0.286 0.020 GO:0008544 BP 1 epidermis development 1 P07476,Q92817 52 1.19e-02 505 7 3 0.429 0.006 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q14134,P07476,P06702 52 1.20e-02 106 7 2 0.286 0.019 GO:0030674 MF 1 protein binding, bridging 1 P07476,Q92817 52 1.29e-02 3 7 1 0.143 0.333 GO:0050542 MF 1 icosanoid binding 1 P06702 52 1.29e-02 3 7 1 0.143 0.333 GO:0002523 BP 1 leukocyte migration involved in inflammatory response 1 P06702 52 1.29e-02 3 7 1 0.143 0.333 GO:0018199 BP 1 peptidyl-glutamine modification 1 P07476 52 1.29e-02 3 7 1 0.143 0.333 GO:0050544 MF 1 arachidonic acid binding 1 P06702 52 1.29e-02 3 7 1 0.143 0.333 GO:1901567 MF 1 fatty acid derivative binding 1 P06702 52 1.29e-02 3 7 1 0.143 0.333 GO:0050543 MF 1 icosatetraenoic acid binding 1 P06702 52 1.38e-02 3208 7 6 0.857 0.002 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P19971,Q14134,P80188,P07476,P06702,Q92817 52 1.48e-02 2072 7 5 0.714 0.002 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 O60437,Q14134,P80188,P07476,Q92817 52 1.54e-02 120 7 2 0.286 0.017 GO:0060090 MF 1 binding, bridging 1 P07476,Q92817 52 1.63e-02 564 7 3 0.429 0.005 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q14134,P07476,P06702 52 1.69e-02 3326 7 6 0.857 0.002 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P19971,O60437,P80188,P07476,P06702,Q92817 52 1.71e-02 4 7 1 0.143 0.250 GO:0035662 MF 1 Toll-like receptor 4 binding 1 P06702 52 1.71e-02 4 7 1 0.143 0.250 GO:1901678 BP 1 iron coordination entity transport 1 P80188 52 1.94e-02 2197 7 5 0.714 0.002 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702 52 2.25e-02 1204 7 4 0.571 0.003 GO:0005856 CC 1 cytoskeleton 1 O60437,Q14134,P06702,Q92817 52 2.44e-02 650 7 3 0.429 0.005 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q14134,P06702,Q92817 52 2.51e-02 3 7 1 0.143 0.333 HP:0002254 hp 1 Intermittent diarrhea 1 P19971 52 2.51e-02 3 7 1 0.143 0.333 HP:0100613 hp 1 Death in early adulthood 1 P19971 52 2.57e-02 6 7 1 0.143 0.167 GO:0050832 BP 1 defense response to fungus 1 P06702 52 2.57e-02 6 7 1 0.143 0.167 GO:0004645 MF 1 phosphorylase activity 1 P19971 52 2.61e-02 2194 7 5 0.714 0.002 GO:0070062 CC 1 extracellular exosome 1 O60437,P80188,P07476,P06702,Q92817 52 2.67e-02 2205 7 5 0.714 0.002 GO:1903561 CC 1 extracellular vesicle 1 O60437,P80188,P07476,P06702,Q92817 52 2.67e-02 2205 7 5 0.714 0.002 GO:0043230 CC 1 extracellular organelle 1 O60437,P80188,P07476,P06702,Q92817 52 2.71e-02 1396 7 4 0.571 0.003 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702 52 2.71e-02 582 7 3 0.429 0.005 GO:0005912 CC 1 adherens junction 1 O60437,Q14134,Q92817 52 2.83e-02 591 7 3 0.429 0.005 GO:0070161 CC 1 anchoring junction 1 O60437,Q14134,Q92817 52 2.94e-02 5381 7 7 1.000 0.001 HPA:004010 hpa 1 breast; adipocytes 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 3.00e-02 7 7 1 0.143 0.143 GO:0036041 MF 1 long-chain fatty acid binding 1 P06702 52 3.23e-02 2456 7 5 0.714 0.002 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P80188,Q92817 52 3.35e-02 5483 7 7 1.000 0.001 HPA:046030_02 hpa 1 tonsil; squamous epithelial cells[Uncertain,Medium] 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 3.41e-02 733 7 3 0.429 0.004 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q14134,P06702,Q92817 52 3.42e-02 8 7 1 0.143 0.125 GO:0035325 MF 1 Toll-like receptor binding 1 P06702 52 3.42e-02 8 7 1 0.143 0.125 GO:0050786 MF 1 RAGE receptor binding 1 P06702 52 3.63e-02 1513 7 4 0.571 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702 52 3.83e-02 1535 7 4 0.571 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P19971,Q14134,P07476,P06702 52 3.85e-02 9 7 1 0.143 0.111 GO:0010224 BP 1 response to UV-B 1 P07476 52 3.85e-02 9 7 1 0.143 0.111 GO:0018119 BP 1 peptidyl-cysteine S-nitrosylation 1 P06702 52 3.85e-02 9 7 1 0.143 0.111 GO:0009620 BP 1 response to fungus 1 P06702 52 3.85e-02 9 7 1 0.143 0.111 GO:0017014 BP 1 protein nitrosylation 1 P06702 52 4.17e-02 5 7 1 0.143 0.200 HP:0003434 hp 1 Sensory ataxic neuropathy 1 P19971 52 4.28e-02 10 7 1 0.143 0.100 GO:0032119 BP 1 sequestering of zinc ion 1 P06702 52 4.40e-02 803 7 3 0.429 0.004 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 P19971,P80188,P06702 52 5.00e-02 35 7 1 0.143 0.029 KEGG:00983 keg 1 Drug metabolism - other enzymes 1 P19971 52 5.00e-02 11 7 1 0.143 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 P19971 52 5.00e-02 1920 7 6 0.857 0.003 TF:M07292_1 tf 1 Factor: GLI; motif: NTGGGTGGTN; match class: 1 1 P19971,Q14134,P80188,P07476,P06702,Q92817 52 5.00e-02 10 7 1 0.143 0.100 REAC:73614 rea 1 Pyrimidine salvage reactions 1 P19971 52 5.00e-02 6 7 1 0.143 0.167 HP:0002578 hp 1 Gastroparesis 1 P19971 52 5.00e-02 219 7 2 0.286 0.009 GO:0030855 BP 1 epithelial cell differentiation 1 P07476,Q92817 52 5.00e-02 5806 7 7 1.000 0.001 HPA:040010 hpa 1 soft tissue 2; adipocytes 1 P19971,O60437,Q14134,P80188,P07476,P06702,Q92817 52 5.00e-02 386 7 3 0.429 0.008 MI:hsa-miR-940 mi 1 MI:hsa-miR-940 1 P19971,P80188,P06702 53 2.30e-03 1 4 1 0.250 1.000 OMIM:604370 omi 1 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED;;OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED 1 P38398 53 2.30e-03 1 4 1 0.250 1.000 OMIM:612651 omi 1 ENDOCRINE-CEREBROOSTEODYSPLASIA; ECO 1 Q9UPZ9 53 2.30e-03 1 4 1 0.250 1.000 OMIM:614320 omi 1 PANCREATIC CANCER, SUSCEPTIBILITY TO, 4; PNCA4 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:2824 cor 1 BRCA1-RAD51 complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:2811 cor 1 BRCA1-cABL complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:2820 cor 1 BRCA1-VCP complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:201 cor 1 HUIC complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:242 cor 1 BRCA1-BACH1 complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:2776 cor 1 RAD50-BRCA1 complex 1 P38398 53 3.91e-03 2 4 1 0.250 0.500 CORUM:2813 cor 1 BRCA1-SMAD3 complex 1 P38398 53 4.48e-03 472 4 3 0.750 0.006 GO:0004672 MF 1 protein kinase activity 1 Q00537,Q00536,Q9UPZ9 53 5.86e-03 3 4 1 0.250 0.333 CORUM:436 cor 1 BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex) 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2783 cor 1 BARD1-BRCA1-CSTF64 complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2823 cor 1 BRCA1-BARD1-UbcH7c complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:240 cor 1 BRCA1-CTIP-ZBRK1 repressor complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2819 cor 1 BRCA1-CtIP-CtBP complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2213 cor 1 BRCA1-BARD1-POLR2A complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2788 cor 1 BRCA1 B complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2818 cor 1 BRCA1-BARD1-BRCA2-DNA damage complex III 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2822 cor 1 BRCA1-BARD1-UbcH5c complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2215 cor 1 BRCA1-LMO4-CTIP complex 1 P38398 53 5.86e-03 3 4 1 0.250 0.333 CORUM:2814 cor 1 BRCA1-HDAC1-HDAC2 complex 1 P38398 53 5.88e-03 1 4 1 0.250 1.000 GO:0035720 BP 1 intraciliary anterograde transport 1 Q9UPZ9 53 5.88e-03 1 4 1 0.250 1.000 GO:0070510 BP 1 regulation of histone H4-K20 methylation 1 P38398 53 5.88e-03 1 4 1 0.250 1.000 GO:0070512 BP 1 positive regulation of histone H4-K20 methylation 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:2786 cor 1 BRCA1 A complex 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:2210 cor 1 BRCA1-IRIS-pre-replication complex 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:2214 cor 1 LMO4-BRCA1-CTIP-LDB1 complex 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:2787 cor 1 BRCA1 C complex 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:964 cor 1 BRCA1-RAD50-MRE11-NBS1 complex 1 P38398 53 7.80e-03 4 4 1 0.250 0.250 CORUM:202 cor 1 BRCA1-RAD50-MRE11-NBS1 complex 1 P38398 53 8.18e-03 578 4 3 0.750 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 Q00537,Q00536,Q9UPZ9 53 8.26e-03 1715 4 4 1.000 0.002 GO:0016740 MF 1 transferase activity 1 P38398,Q00537,Q00536,Q9UPZ9 53 9.75e-03 5 4 1 0.250 0.200 CORUM:5400 cor 1 BRCC complex 1 P38398 53 9.75e-03 5 4 1 0.250 0.200 CORUM:2211 cor 1 BARD1-BRCA1-CSTF complex 1 P38398 53 1.06e-02 630 4 3 0.750 0.005 GO:0016301 MF 1 kinase activity 1 Q00537,Q00536,Q9UPZ9 53 1.17e-02 6 4 1 0.250 0.167 CORUM:2817 cor 1 BRCA1-BARD1-BACH1-DNA damage complex I 1 P38398 53 1.17e-02 6 4 1 0.250 0.167 CORUM:435 cor 1 BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) 1 P38398 53 1.18e-02 2 4 1 0.250 0.500 GO:0031436 CC 1 BRCA1-BARD1 complex 1 P38398 53 1.18e-02 2 4 1 0.250 0.500 GO:0009048 BP 1 dosage compensation by inactivation of X chromosome 1 P38398 53 1.18e-02 2 4 1 0.250 0.500 GO:0034770 BP 1 histone H4-K20 methylation 1 P38398 53 1.18e-02 2 4 1 0.250 0.500 GO:2000620 BP 1 positive regulation of histone H4-K16 acetylation 1 P38398 53 1.56e-02 8 4 1 0.250 0.125 CORUM:2815 cor 1 BRCA1-BARD1-BACH1-DNA damage complex II 1 P38398 53 1.56e-02 8 4 1 0.250 0.125 CORUM:434 cor 1 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) 1 P38398 53 1.80e-02 755 4 3 0.750 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q00537,Q00536,Q9UPZ9 53 1.90e-02 769 4 3 0.750 0.004 GO:0015630 CC 1 microtubule cytoskeleton 1 P38398,Q00536,Q9UPZ9 53 1.94e-02 10 4 1 0.250 0.100 CORUM:438 cor 1 GCN5-TRRAP histone acetyltransferase complex 1 P38398 53 2.14e-02 11 4 1 0.250 0.091 CORUM:238 cor 1 SWI-SNF chromatin remodeling-related-BRCA1 complex 1 P38398 53 2.33e-02 12 4 1 0.250 0.083 CORUM:433 cor 1 BASC complex (BRCA1-associated genome surveillance complex) 1 P38398 53 2.35e-02 4 4 1 0.250 0.250 GO:0007549 BP 1 dosage compensation 1 P38398 53 2.35e-02 4 4 1 0.250 0.250 GO:2000617 BP 1 positive regulation of histone H3-K9 acetylation 1 P38398 53 2.39e-02 713 4 2 0.500 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P38398,Q00536 53 2.42e-02 26 4 1 0.250 0.038 REAC:5693554 rea 1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 P38398 53 2.52e-02 13 4 1 0.250 0.077 CORUM:2686 cor 1 BRCA1-core RNA polymerase II complex 1 P38398 53 2.56e-02 2275 4 4 1.000 0.002 GO:0006464 BP 1 cellular protein modification process 1 P38398,Q00537,Q00536,Q9UPZ9 53 2.56e-02 2275 4 4 1.000 0.002 GO:0036211 BP 1 protein modification process 1 P38398,Q00537,Q00536,Q9UPZ9 53 2.64e-02 9 4 1 0.250 0.111 HP:0000437 hp 1 Depressed nasal tip 1 Q9UPZ9 53 2.67e-02 2146 4 3 0.750 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 Q00537,Q00536,Q9UPZ9 53 2.70e-02 29 4 1 0.250 0.034 REAC:5693568 rea 1 Resolution of D-loop Structures through Holliday Junction Intermediates 1 P38398 53 2.79e-02 30 4 1 0.250 0.033 REAC:5693537 rea 1 Resolution of D-Loop Structures 1 P38398 53 2.94e-02 5 4 1 0.250 0.200 GO:0000800 CC 1 lateral element 1 P38398 53 2.94e-02 5 4 1 0.250 0.200 GO:0051573 BP 1 negative regulation of histone H3-K9 methylation 1 P38398 53 2.94e-02 5 4 1 0.250 0.200 GO:2000618 BP 1 regulation of histone H4-K16 acetylation 1 P38398 53 2.94e-02 5 4 1 0.250 0.200 GO:0071681 BP 1 cellular response to indole-3-methanol 1 P38398 53 2.94e-02 5 4 1 0.250 0.200 GO:0030252 BP 1 growth hormone secretion 1 Q00536 53 2.94e-02 5 4 1 0.250 0.200 GO:0071680 BP 1 response to indole-3-methanol 1 P38398 53 3.10e-02 4530 4 4 1.000 0.001 HPA:008010_02 hpa 1 cervix, uterine; glandular cells[Uncertain,Medium] 1 P38398,Q00537,Q00536,Q9UPZ9 53 3.22e-02 4574 4 4 1.000 0.001 HPA:021010_01 hpa 1 liver; bile duct cells[Uncertain,Low] 1 P38398,Q00537,Q00536,Q9UPZ9 53 3.22e-02 11 4 1 0.250 0.091 HP:0100787 hp 1 Prostate neoplasm 1 P38398 53 3.22e-02 11 4 1 0.250 0.091 HP:0012125 hp 1 Prostate cancer 1 P38398 53 3.26e-02 2417 4 4 1.000 0.002 GO:0043412 BP 1 macromolecule modification 1 P38398,Q00537,Q00536,Q9UPZ9 53 3.35e-02 36 4 1 0.250 0.028 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 P38398 53 3.53e-02 6 4 1 0.250 0.167 GO:0046600 BP 1 negative regulation of centriole replication 1 P38398 53 3.53e-02 6 4 1 0.250 0.167 GO:0090240 BP 1 positive regulation of histone H4 acetylation 1 P38398 53 3.53e-02 38 4 1 0.250 0.026 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 P38398 53 3.81e-02 41 4 1 0.250 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 P38398 53 3.81e-02 41 4 1 0.250 0.024 REAC:912446 rea 1 Meiotic recombination 1 P38398 53 3.93e-02 927 4 2 0.500 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 P38398,Q00536 53 3.99e-02 43 4 1 0.250 0.023 REAC:1221632 rea 1 Meiotic synapsis 1 P38398 53 4.11e-02 7 4 1 0.250 0.143 GO:0008274 CC 1 gamma-tubulin ring complex 1 P38398 53 4.11e-02 7 4 1 0.250 0.143 GO:0000931 CC 1 gamma-tubulin large complex 1 P38398 53 4.11e-02 7 4 1 0.250 0.143 GO:0070531 CC 1 BRCA1-A complex 1 P38398 53 4.11e-02 7 4 1 0.250 0.143 GO:0033147 BP 1 negative regulation of intracellular estrogen receptor signaling pathway 1 P38398 53 4.11e-02 7 4 1 0.250 0.143 GO:0085020 BP 1 protein K6-linked ubiquitination 1 P38398 53 4.27e-02 46 4 1 0.250 0.022 REAC:5693571 rea 1 Nonhomologous End-Joining (NHEJ) 1 P38398 53 4.39e-02 15 4 1 0.250 0.067 HP:0008775 hp 1 Abnormality of the prostate 1 P38398 53 4.39e-02 15 4 1 0.250 0.067 HP:0000914 hp 1 Shield chest 1 Q9UPZ9 53 4.67e-02 16 4 1 0.250 0.062 HP:0030260 hp 1 Microphallus 1 Q9UPZ9 53 4.70e-02 8 4 1 0.250 0.125 GO:0010826 BP 1 negative regulation of centrosome duplication 1 P38398 53 4.70e-02 8 4 1 0.250 0.125 GO:0043970 BP 1 histone H3-K9 acetylation 1 P38398 53 4.70e-02 8 4 1 0.250 0.125 GO:0035721 BP 1 intraciliary retrograde transport 1 Q9UPZ9 53 4.70e-02 8 4 1 0.250 0.125 GO:0046606 BP 1 negative regulation of centrosome cycle 1 P38398 53 4.70e-02 8 4 1 0.250 0.125 GO:2000615 BP 1 regulation of histone H3-K9 acetylation 1 P38398 53 4.91e-02 53 4 1 0.250 0.019 REAC:5693565 rea 1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 P38398 53 4.96e-02 17 4 1 0.250 0.059 HP:0002585 hp 1 Abnormality of the peritoneum 1 P38398 53 5.00e-02 391 4 3 0.750 0.008 TF:M04088_1 tf 1 Factor: POU5F1B; motif: TATGCWAAT; match class: 1 1 P38398,Q00537,Q00536 53 5.00e-02 40 4 1 0.250 0.025 KEGG:03440 keg 1 Homologous recombination 1 P38398 53 5.00e-02 391 4 3 0.750 0.008 TF:M04072_1 tf 1 Factor: POU2F2; motif: NTATGCWAATN; match class: 1 1 P38398,Q00537,Q00536 53 5.00e-02 1068 4 3 0.750 0.003 GO:0006468 BP 1 protein phosphorylation 1 Q00537,Q00536,Q9UPZ9 53 5.00e-02 22 4 1 0.250 0.045 OMIM:260350 omi 1 Pancreatic Cancer 1 P38398 53 5.00e-02 26 4 1 0.250 0.038 CORUM:2825 cor 1 BRCA1-RNA polymerase II complex 1 P38398 53 5.00e-02 54 4 1 0.250 0.019 REAC:5693606 rea 1 DNA Double Strand Break Response 1 P38398 54 3.51e-03 2 4 1 0.250 0.500 CORUM:180 cor 1 PNUTS-PP1 complex 1 P62136 54 6.65e-03 382 4 2 0.500 0.005 MI:hsa-miR-637 mi 1 MI:hsa-miR-637 1 P62136,Q8IX15 54 1.57e-02 9 4 1 0.250 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P62136 54 3.10e-02 4530 4 4 1.000 0.001 HPA:008010_02 hpa 1 cervix, uterine; glandular cells[Uncertain,Medium] 1 O75864,P62136,Q8IX15,A8MZ97 54 4.16e-02 4876 4 4 1.000 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 O75864,P62136,Q8IX15,A8MZ97 54 4.20e-02 54 4 1 0.250 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 P62136 54 4.58e-02 59 4 1 0.250 0.017 KEGG:04720 keg 1 Long-term potentiation 1 P62136 54 5.00e-02 29 4 1 0.250 0.034 CORUM:1183 cor 1 CDC5L complex 1 P62136 54 5.00e-02 72 4 2 0.500 0.028 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 O75864,P62136 54 5.00e-02 14 4 1 0.250 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P62136 54 5.00e-02 1 4 1 0.250 1.000 GO:0036496 BP 1 regulation of translational initiation by eIF2 alpha dephosphorylation 1 P62136 55 1.94e-03 1 3 1 0.333 1.000 OMIM:614874 omi 1 CILIARY DYSKINESIA, PRIMARY, 18; CILD18;;CILIARY DYSKINESIA, PRIMARY, 18, WITH OR WITHOUT SITUS INVERSUS 1 Q86Y56 55 1.94e-03 1 3 1 0.333 1.000 OMIM:208900 omi 1 ATAXIA-TELANGIECTASIA; AT;;AT1;;LOUIS-BAR SYNDROMEAT, COMPLEMENTATION GROUP A, INCLUDED; ATA, INCLUDED;;AT, COMPLEMENTATION GROUP C, INCLUDED; ATC, INCLUDED;;AT, COMPLEMENTATION GROUP D, INCLUDED; ATD, INCLUDED;;AT, COMPLEMENTATION GROUP E, INCLUDED; ATE, INCLUDED;;ATAXIA-TELANGIECTASIA VARIANT, INCLUDED 1 Q13315 55 3.53e-03 6 3 1 0.333 0.167 REAC:5693548 rea 1 Sensing of DNA Double Strand Breaks 1 Q13315 55 4.19e-03 1 3 1 0.333 1.000 CORUM:5369 cor 1 ATM homodimer complex 1 Q13315 55 5.29e-03 9 3 1 0.333 0.111 REAC:6803207 rea 1 TP53 Regulates Transcription of Caspase Activators and Caspases 1 Q13315 55 5.84e-03 502 3 2 0.667 0.004 MI:mmu-miR-703 mi 1 MI:mmu-miR-703 1 Q9UIA9,Q86Y56 55 6.08e-03 3 3 1 0.333 0.333 TF:M05498_1 tf 1 Factor: DRRS; motif: NGTAGTCAGC; match class: 1 1 Q13315 55 8.37e-03 2 3 1 0.333 0.500 CORUM:2723 cor 1 ATM-NBS1 complex 1 Q13315 55 8.81e-03 15 3 1 0.333 0.067 REAC:6803204 rea 1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:0002331 BP 1 pre-B cell allelic exclusion 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:1904882 BP 1 regulation of telomerase catalytic core complex assembly 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:1905323 BP 1 telomerase holoenzyme complex assembly 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:1904868 BP 1 telomerase catalytic core complex assembly 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:0072425 BP 1 signal transduction involved in G2 DNA damage checkpoint 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:1904884 BP 1 positive regulation of telomerase catalytic core complex assembly 1 Q13315 55 9.10e-03 2 3 1 0.333 0.500 GO:0072434 BP 1 signal transduction involved in mitotic G2 DNA damage checkpoint 1 Q13315 55 1.06e-02 18 3 1 0.333 0.056 REAC:6804760 rea 1 Regulation of TP53 Activity through Methylation 1 Q13315 55 1.36e-02 3 3 1 0.333 0.333 GO:0097695 BP 1 establishment of macromolecular complex localization to telomere 1 Q13315 55 1.36e-02 3 3 1 0.333 0.333 GO:0071500 BP 1 cellular response to nitrosative stress 1 Q13315 55 1.36e-02 3 3 1 0.333 0.333 GO:0002329 BP 1 pre-B cell differentiation 1 Q13315 55 1.36e-02 3 3 1 0.333 0.333 GO:0097694 BP 1 establishment of RNA localization to telomere 1 Q13315 55 1.36e-02 3 3 1 0.333 0.333 GO:0004677 MF 1 DNA-dependent protein kinase activity 1 Q13315 55 1.52e-02 26 3 1 0.333 0.038 REAC:5693554 rea 1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 Q13315 55 1.70e-02 29 3 1 0.333 0.034 REAC:5693568 rea 1 Resolution of D-loop Structures through Holliday Junction Intermediates 1 Q13315 55 1.76e-02 30 3 1 0.333 0.033 REAC:5693537 rea 1 Resolution of D-Loop Structures 1 Q13315 55 1.82e-02 4 3 1 0.333 0.250 GO:0002327 BP 1 immature B cell differentiation 1 Q13315 55 1.82e-02 4 3 1 0.333 0.250 GO:0051409 BP 1 response to nitrosative stress 1 Q13315 55 1.82e-02 4 3 1 0.333 0.250 GO:0036289 BP 1 peptidyl-serine autophosphorylation 1 Q13315 55 1.82e-02 4 3 1 0.333 0.250 GO:0030889 BP 1 negative regulation of B cell proliferation 1 Q13315 55 1.87e-02 52 3 2 0.667 0.038 HP:0002837 hp 1 Recurrent bronchitis 1 Q13315,Q86Y56 55 1.87e-02 32 3 1 0.333 0.031 REAC:6804757 rea 1 Regulation of TP53 Degradation 1 Q13315 55 1.92e-02 1 3 1 0.333 1.000 HP:0009067 hp 1 Progressive spinal muscular atrophy 1 Q13315 55 1.92e-02 1 3 1 0.333 1.000 HP:0000134 hp 1 Female hypogonadism 1 Q13315 55 1.92e-02 1 3 1 0.333 1.000 HP:0005357 hp 1 Defective B cell differentiation 1 Q13315 55 1.93e-02 33 3 1 0.333 0.030 REAC:5633008 rea 1 TP53 Regulates Transcription of Cell Death Genes 1 Q13315 55 1.93e-02 33 3 1 0.333 0.030 REAC:6806003 rea 1 Regulation of TP53 Expression and Degradation 1 Q13315 55 1.95e-02 354 3 2 0.667 0.006 TF:M07380_1 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 1 Q9UIA9,Q86Y56 55 2.11e-02 36 3 1 0.333 0.028 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 Q13315 55 2.22e-02 38 3 1 0.333 0.026 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 Q13315 55 2.23e-02 11 3 1 0.333 0.091 TF:M04069_1 tf 1 Factor: POU1F1; motif: AWTATGCWAATKAG; match class: 1 1 Q9UIA9 55 2.27e-02 5 3 1 0.333 0.200 GO:1904354 BP 1 negative regulation of telomere capping 1 Q13315 55 2.27e-02 5 3 1 0.333 0.200 GO:0045505 MF 1 dynein intermediate chain binding 1 Q86Y56 55 2.27e-02 5 3 1 0.333 0.200 GO:0071481 BP 1 cellular response to X-ray 1 Q13315 55 2.40e-02 41 3 1 0.333 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 Q13315 55 2.40e-02 41 3 1 0.333 0.024 REAC:912446 rea 1 Meiotic recombination 1 Q13315 55 2.41e-02 59 3 2 0.667 0.034 HP:0002110 hp 1 Bronchiectasis 1 Q13315,Q86Y56 55 2.49e-02 60 3 2 0.667 0.033 HP:0012387 hp 1 Bronchitis 1 Q13315,Q86Y56 55 2.51e-02 6 3 1 0.333 0.167 CORUM:2217 cor 1 MDC1-MRN-ATM-FANCD2 complex 1 Q13315 55 2.51e-02 6 3 1 0.333 0.167 CORUM:435 cor 1 BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) 1 Q13315 55 2.69e-02 46 3 1 0.333 0.022 REAC:5693571 rea 1 Nonhomologous End-Joining (NHEJ) 1 Q13315 55 2.81e-02 48 3 1 0.333 0.021 REAC:2559586 rea 1 DNA Damage/Telomere Stress Induced Senescence 1 Q13315 55 2.83e-02 40 3 1 0.333 0.025 KEGG:03440 keg 1 Homologous recombination 1 Q13315 55 2.98e-02 51 3 1 0.333 0.020 REAC:349425 rea 1 Autodegradation of the E3 ubiquitin ligase COP1 1 Q13315 55 3.04e-02 15 3 1 0.333 0.067 TF:M04079_1 tf 1 Factor: POU3F2; motif: WTATGCWAATKA; match class: 1 1 Q9UIA9 55 3.04e-02 52 3 1 0.333 0.019 REAC:69613 rea 1 p53-Independent G1/S DNA damage checkpoint 1 Q13315 55 3.04e-02 52 3 1 0.333 0.019 REAC:69610 rea 1 p53-Independent DNA Damage Response 1 Q13315 55 3.04e-02 52 3 1 0.333 0.019 REAC:69601 rea 1 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1 Q13315 55 3.07e-02 445 3 2 0.667 0.004 TF:M02044_0 tf 1 Factor: YY1; motif: GCCGCCATTTTG; match class: 0 1 Q9UIA9,Q86Y56 55 3.10e-02 53 3 1 0.333 0.019 REAC:5693565 rea 1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 Q13315 55 3.15e-02 54 3 1 0.333 0.019 REAC:5693606 rea 1 DNA Double Strand Break Response 1 Q13315 55 3.15e-02 54 3 1 0.333 0.019 REAC:69541 rea 1 Stabilization of p53 1 Q13315 55 3.50e-02 60 3 1 0.333 0.017 REAC:6796648 rea 1 TP53 Regulates Transcription of DNA Repair Genes 1 Q13315 55 3.56e-02 61 3 1 0.333 0.016 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q13315 55 3.64e-02 8 3 1 0.333 0.125 GO:0005049 MF 1 nuclear export signal receptor activity 1 Q9UIA9 55 3.64e-02 8 3 1 0.333 0.125 GO:0006975 BP 1 DNA damage induced protein phosphorylation 1 Q13315 55 3.64e-02 8 3 1 0.333 0.125 GO:1904262 BP 1 negative regulation of TORC1 signaling 1 Q13315 55 3.64e-02 8 3 1 0.333 0.125 GO:0090399 BP 1 replicative senescence 1 Q13315 55 3.67e-02 63 3 1 0.333 0.016 REAC:69580 rea 1 p53-Dependent G1/S DNA damage checkpoint 1 Q13315 55 3.67e-02 63 3 1 0.333 0.016 REAC:69563 rea 1 p53-Dependent G1 DNA Damage Response 1 Q13315 55 3.79e-02 65 3 1 0.333 0.015 REAC:69615 rea 1 G1/S DNA Damage Checkpoints 1 Q13315 55 3.84e-02 2 3 1 0.333 0.500 HP:0005384 hp 1 Defective B cell activation 1 Q13315 55 3.90e-02 75 3 2 0.667 0.027 HP:0000246 hp 1 Sinusitis 1 Q13315,Q86Y56 55 3.96e-02 56 3 1 0.333 0.018 KEGG:04115 keg 1 p53 signaling pathway 1 Q13315 55 3.96e-02 68 3 1 0.333 0.015 REAC:1500620 rea 1 Meiosis 1 Q13315 55 4.05e-02 21 3 1 0.333 0.048 OMIM:114480 omi 1 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED 1 Q13315 55 4.09e-02 9 3 1 0.333 0.111 GO:0050869 BP 1 negative regulation of B cell activation 1 Q13315 55 4.09e-02 9 3 1 0.333 0.111 GO:0043517 BP 1 positive regulation of DNA damage response, signal transduction by p53 class mediator 1 Q13315 55 4.19e-02 72 3 1 0.333 0.014 REAC:69473 rea 1 G2/M DNA damage checkpoint 1 Q13315 55 4.24e-02 22 3 1 0.333 0.045 OMIM:260350 omi 1 Pancreatic Cancer 1 Q13315 55 4.31e-02 74 3 1 0.333 0.014 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 Q13315 55 4.37e-02 75 3 1 0.333 0.013 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 Q13315 55 4.43e-02 80 3 2 0.667 0.025 HP:0000025 hp 1 Functional abnormality of male internal genitalia 1 Q13315,Q86Y56 55 4.54e-02 81 3 2 0.667 0.025 HP:0002109 hp 1 Abnormality of the bronchi 1 Q13315,Q86Y56 55 4.55e-02 10 3 1 0.333 0.100 GO:0071480 BP 1 cellular response to gamma radiation 1 Q13315 55 4.55e-02 10 3 1 0.333 0.100 GO:0036159 BP 1 inner dynein arm assembly 1 Q86Y56 55 4.68e-02 551 3 2 0.667 0.004 TF:M00223_0 tf 1 Factor: STAT; motif: TTCCCGKAA; match class: 0 1 Q9UIA9,Q13315 55 4.79e-02 68 3 1 0.333 0.015 KEGG:04064 keg 1 NF-kappa B signaling pathway 1 Q13315 55 5.00e-02 71 3 1 0.333 0.014 KEGG:01524 keg 1 Platinum drug resistance 1 Q13315 55 5.00e-02 2290 3 3 1.000 0.001 TF:M07347_0 tf 1 Factor: AhR; motif: NNNKNGCGTGNSNNNNN; match class: 0 1 Q9UIA9,Q13315,Q86Y56 55 5.00e-02 26 3 1 0.333 0.038 OMIM:244400 omi 1 Primary Ciliary Dyskinesia 1 Q86Y56 55 5.00e-02 86 3 1 0.333 0.012 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q13315 55 5.00e-02 11 3 1 0.333 0.091 GO:0007095 BP 1 mitotic G2 DNA damage checkpoint 1 Q13315 55 5.00e-02 12 3 1 0.333 0.083 CORUM:433 cor 1 BASC complex (BRCA1-associated genome surveillance complex) 1 Q13315 55 5.00e-02 85 3 2 0.667 0.024 HP:0000245 hp 1 Abnormality of the paranasal sinuses 1 Q13315,Q86Y56 56 4.75e-03 13 2 1 0.500 0.077 REAC:211227 rea 1 Activation of DNA fragmentation factor 1 P10412 56 4.75e-03 13 2 1 0.500 0.077 REAC:140342 rea 1 Apoptosis induced DNA fragmentation 1 P10412 56 5.02e-03 32 2 1 0.500 0.031 TF:M04133_1 tf 1 Factor: TBX2; motif: GGTGTGANAWNTSACACC; match class: 1 1 P10412 56 5.85e-03 16 2 1 0.500 0.062 REAC:2559584 rea 1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1 P10412 56 6.44e-03 867 2 2 1.000 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 P10412,Q8N655 56 8.53e-03 1176 2 2 1.000 0.002 TF:M01124_0 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 0 1 P10412,Q8N655 56 9.25e-03 59 2 1 0.500 0.017 TF:M06346_0 tf 1 Factor: E4F1; motif: GTSCCGTAATNM; match class: 0 1 Q8N655 56 9.87e-03 1265 2 2 1.000 0.002 TF:M00423_0 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 0 1 P10412,Q8N655 56 1.02e-02 65 2 1 0.500 0.015 TF:M06433_0 tf 1 Factor: ZNF571; motif: NTGTCAASATSM; match class: 0 1 Q8N655 56 1.27e-02 1437 2 2 1.000 0.001 TF:M01279_0 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 0 1 P10412,Q8N655 56 1.35e-02 86 2 1 0.500 0.012 TF:M04133_0 tf 1 Factor: TBX2; motif: GGTGTGANAWNTSACACC; match class: 0 1 P10412 56 1.37e-02 1490 2 2 1.000 0.001 TF:M04013_0 tf 1 Factor: HSFY1; motif: TTCGAANSRTTCGAA; match class: 0 1 P10412,Q8N655 56 1.59e-02 1603 2 2 1.000 0.001 TF:M02055_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 P10412,Q8N655 56 1.59e-02 1603 2 2 1.000 0.001 TF:M01214_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 P10412,Q8N655 56 1.75e-02 48 2 1 0.500 0.021 REAC:2559586 rea 1 DNA Damage/Telomere Stress Induced Senescence 1 P10412 56 1.78e-02 114 2 1 0.500 0.009 TF:M06155_0 tf 1 Factor: ZNF135; motif: NGTKGTGWAATC; match class: 0 1 P10412 56 1.86e-02 51 2 1 0.500 0.020 REAC:75153 rea 1 Apoptotic execution phase 1 P10412 56 1.96e-02 1784 2 2 1.000 0.001 TF:M07299_1 tf 1 Factor: c-Myb; motif: NNNNCMGTTNNN; match class: 1 1 P10412,Q8N655 56 2.11e-02 135 2 1 0.500 0.007 TF:M01882_1 tf 1 Factor: IRF-2; motif: NNRAAAGTGAAASNNA; match class: 1 1 Q8N655 56 2.13e-02 136 2 1 0.500 0.007 TF:M05522_0 tf 1 Factor: ZNF341; motif: NTGGGGGGGGGG; match class: 0 1 P10412 56 2.14e-02 1578 2 2 1.000 0.001 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 P10412,Q8N655 56 2.15e-02 1583 2 2 1.000 0.001 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 P10412,Q8N655 56 2.23e-02 121 2 1 0.500 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 P10412 56 2.41e-02 1976 2 2 1.000 0.001 TF:M06069_0 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 0 1 P10412,Q8N655 56 2.41e-02 131 2 1 0.500 0.008 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 P10412 56 2.47e-02 158 2 1 0.500 0.006 TF:M06398_0 tf 1 Factor: ZNF761; motif: GGKWAATCAGA; match class: 0 1 P10412 56 2.50e-02 136 2 1 0.500 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 P10412 56 2.58e-02 165 2 1 0.500 0.006 TF:M03842_0 tf 1 Factor: POU3F1; motif: RNYBCATTTGCATTWCAA; match class: 0 1 Q8N655 56 2.61e-02 167 2 1 0.500 0.006 TF:M06226_0 tf 1 Factor: ZNF460; motif: KGGGACAGCGGA; match class: 0 1 Q8N655 56 2.64e-02 2068 2 2 1.000 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 P10412,Q8N655 56 2.71e-02 147 2 1 0.500 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 P10412 56 2.72e-02 148 2 1 0.500 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 P10412 56 2.87e-02 1830 2 2 1.000 0.001 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 P10412,Q8N655 56 2.94e-02 160 2 1 0.500 0.006 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 P10412 56 2.98e-02 191 2 1 0.500 0.005 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 P10412 56 3.16e-02 203 2 1 0.500 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 Q8N655 56 3.27e-02 210 2 1 0.500 0.005 TF:M01117_1 tf 1 Factor: OTX; motif: GATTANNT; match class: 1 1 P10412 56 3.35e-02 215 2 1 0.500 0.005 TF:M07082_0 tf 1 Factor: DUX4; motif: TAAYYYAATCA; match class: 0 1 P10412 56 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 P10412,Q8N655 56 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 P10412,Q8N655 56 3.67e-02 200 2 1 0.500 0.005 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 P10412 56 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 P10412 56 3.76e-02 205 2 1 0.500 0.005 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 P10412 56 3.98e-02 217 2 1 0.500 0.005 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 P10412 56 4.01e-02 258 2 1 0.500 0.004 TF:M06576_0 tf 1 Factor: ZNF419; motif: GGGTGGCCGC; match class: 0 1 P10412 56 4.01e-02 258 2 1 0.500 0.004 TF:M06377_0 tf 1 Factor: ZNF773; motif: GGGTGGCCGC; match class: 0 1 P10412 56 4.05e-02 2173 2 2 1.000 0.001 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 P10412,Q8N655 56 4.05e-02 221 2 1 0.500 0.005 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 P10412 56 4.21e-02 238 2 1 0.500 0.004 MI:hsa-miR-32* mi 1 MI:hsa-miR-32* 1 Q8N655 56 4.23e-02 272 2 1 0.500 0.004 TF:M06208_0 tf 1 Factor: ZNF460; motif: NGGGGGGGGGGG; match class: 0 1 P10412 56 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 P10412,Q8N655 56 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 P10412 56 4.32e-02 278 2 1 0.500 0.004 TF:M07363_0 tf 1 Factor: NF-1; motif: NNNGCCAANN; match class: 0 1 P10412 56 4.48e-02 2695 2 2 1.000 0.001 TF:M01258_0 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 0 1 P10412,Q8N655 56 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q8N655 56 4.80e-02 309 2 1 0.500 0.003 TF:M01148_0 tf 1 Factor: DMRT3; motif: NWWTTGWTACAWTKT; match class: 0 1 P10412 56 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 P10412 56 4.85e-02 265 2 1 0.500 0.004 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 P10412 56 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 P10412,Q8N655 56 4.94e-02 270 2 1 0.500 0.004 HPA:040040_03 hpa 1 soft tissue 2; peripheral nerve[Uncertain,High] 1 P10412 56 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 P10412,Q8N655 56 5.00e-02 16 2 1 0.500 0.062 CORUM:642 cor 1 CtBP complex 1 Q8N655 56 5.00e-02 18 2 1 0.500 0.056 GO:0005720 CC 1 nuclear heterochromatin 1 P10412 56 5.00e-02 138 2 1 0.500 0.007 REAC:2559583 rea 1 Cellular Senescence 1 P10412 57 1.66e-03 302 3 2 0.667 0.007 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 P49593,O14578 57 3.06e-03 13 3 1 0.333 0.077 TF:M04138_1 tf 1 Factor: Tbx5; motif: AGGTGTKANWTNTSACACCT; match class: 1 1 P49593 57 3.77e-03 16 3 1 0.333 0.062 TF:M04138_0 tf 1 Factor: Tbx5; motif: AGGTGTKANWTNTSACACCT; match class: 0 1 P49593 57 4.57e-03 504 3 2 0.667 0.004 TF:M06531_0 tf 1 Factor: ZNF555; motif: NCRWGTTTGKCC; match class: 0 1 O14578,Q8IY26 57 5.65e-03 24 3 1 0.333 0.042 TF:M04136_1 tf 1 Factor: TBX4; motif: AGGTGTGANAWNTNACACCT; match class: 1 1 P49593 57 7.19e-03 634 3 2 0.667 0.003 TF:M00413_1 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 1 1 P49593,O14578 57 7.20e-03 2459 3 3 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 P49593,O14578,Q8IY26 57 7.42e-03 4 3 1 0.333 0.250 GO:0033192 MF 1 calmodulin-dependent protein phosphatase activity 1 P49593 57 7.52e-03 32 3 1 0.333 0.031 TF:M04133_1 tf 1 Factor: TBX2; motif: GGTGTGANAWNTSACACC; match class: 1 1 P49593 57 9.60e-03 2706 3 3 1.000 0.001 TF:M01856_0 tf 1 Factor: AML3; motif: AACCACAN; match class: 0 1 P49593,O14578,Q8IY26 57 9.60e-03 2706 3 3 1.000 0.001 TF:M01759_0 tf 1 Factor: AML2; motif: AACCRCAA; match class: 0 1 P49593,O14578,Q8IY26 57 1.11e-02 6 3 1 0.333 0.167 GO:0004723 MF 1 calcium-dependent protein serine/threonine phosphatase activity 1 P49593 57 1.11e-02 6 3 1 0.333 0.167 GO:0044387 BP 1 negative regulation of protein kinase activity by regulation of protein phosphorylation 1 P49593 57 1.13e-02 48 3 1 0.333 0.021 TF:M01037_1 tf 1 Factor: GLI; motif: NBTGGGTGGTCN; match class: 1 1 P49593 57 1.15e-02 804 3 2 0.667 0.002 TF:M00734_0 tf 1 Factor: CIZ; motif: SAAAAANNN; match class: 0 1 P49593,Q8IY26 57 1.38e-02 59 3 1 0.333 0.017 TF:M04136_0 tf 1 Factor: TBX4; motif: AGGTGTGANAWNTNACACCT; match class: 0 1 P49593 57 1.48e-02 8 3 1 0.333 0.125 GO:0035970 BP 1 peptidyl-threonine dephosphorylation 1 P49593 57 1.55e-02 940 3 2 0.667 0.002 TF:M06080_0 tf 1 Factor: ZNF99; motif: KGGKGTGAGA; match class: 0 1 O14578,Q8IY26 57 1.85e-02 10 3 1 0.333 0.100 GO:0051894 BP 1 positive regulation of focal adhesion assembly 1 P49593 57 1.94e-02 3420 3 3 1.000 0.001 TF:M04237_0 tf 1 Factor: FOXC2; motif: WAWGTAAACAWW; match class: 0 1 P49593,O14578,Q8IY26 57 2.01e-02 86 3 1 0.333 0.012 TF:M04133_0 tf 1 Factor: TBX2; motif: GGTGTGANAWNTSACACC; match class: 0 1 P49593 57 2.01e-02 86 3 1 0.333 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 Q8IY26 57 2.04e-02 11 3 1 0.333 0.091 GO:1903393 BP 1 positive regulation of adherens junction organization 1 P49593 57 2.16e-02 3547 3 3 1.000 0.001 TF:M00413_0 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 0 1 P49593,O14578,Q8IY26 57 2.55e-02 109 3 1 0.333 0.009 TF:M07098_1 tf 1 Factor: HNF-4gamma; motif: NNRGNNCAAAGKYCA; match class: 1 1 Q8IY26 57 2.76e-02 3848 3 3 1.000 0.001 TF:M03888_1 tf 1 Factor: Sox6; motif: NARACAAAARN; match class: 1 1 P49593,O14578,Q8IY26 57 2.78e-02 15 3 1 0.333 0.067 GO:1901890 BP 1 positive regulation of cell junction assembly 1 P49593 57 2.81e-02 1276 3 2 0.667 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 O14578,Q8IY26 57 2.87e-02 123 3 1 0.333 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 P49593 57 2.97e-02 16 3 1 0.333 0.062 GO:0033137 BP 1 negative regulation of peptidyl-serine phosphorylation 1 P49593 57 3.13e-02 134 3 1 0.333 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q8IY26 57 3.15e-02 17 3 1 0.333 0.059 GO:0001954 BP 1 positive regulation of cell-matrix adhesion 1 P49593 57 3.17e-02 1357 3 2 0.667 0.001 TF:M07391_1 tf 1 Factor: NKX2B; motif: ANNCACTTNA; match class: 1 1 O14578,Q8IY26 57 3.31e-02 142 3 1 0.333 0.007 TF:M07115_0 tf 1 Factor: NF-YB; motif: NNNYNRRCCAATCAG; match class: 0 1 O14578 57 3.49e-02 150 3 1 0.333 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 P49593 57 3.75e-02 161 3 1 0.333 0.006 TF:M05322_0 tf 1 Factor: T-box; motif: TTCACACCTR; match class: 0 1 P49593 57 3.80e-02 1493 3 2 0.667 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 O14578,Q8IY26 57 4.01e-02 4357 3 3 1.000 0.001 TF:M02028_0 tf 1 Factor: Pbx1; motif: ATCAATCAN; match class: 0 1 P49593,O14578,Q8IY26 57 4.01e-02 4359 3 3 1.000 0.001 TF:M00083_0 tf 1 Factor: MZF-1; motif: NGNGGGGA; match class: 0 1 P49593,O14578,Q8IY26 57 4.08e-02 22 3 1 0.333 0.045 GO:0051496 BP 1 positive regulation of stress fiber assembly 1 P49593 57 4.16e-02 179 3 1 0.333 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 O14578 57 4.26e-02 4447 3 3 1.000 0.001 TF:M07304_0 tf 1 Factor: Pbx; motif: NTGATTGANN; match class: 0 1 P49593,O14578,Q8IY26 57 4.45e-02 24 3 1 0.333 0.042 GO:0035690 BP 1 cellular response to drug 1 P49593 57 4.63e-02 25 3 1 0.333 0.040 GO:0032467 BP 1 positive regulation of cytokinesis 1 O14578 57 4.74e-02 3907 3 3 1.000 0.001 HPA:012010_01 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Low] 1 P49593,O14578,Q8IY26 57 5.00e-02 16 3 1 0.333 0.062 REAC:5625900 rea 1 RHO GTPases activate CIT 1 O14578 58 2.07e-02 12 2 1 0.500 0.083 GO:0045879 BP 1 negative regulation of smoothened signaling pathway 1 Q9UMX1 58 2.37e-02 58 2 1 0.500 0.017 REAC:5610783 rea 1 Degradation of GLI2 by the proteasome 1 Q9UMX1 58 2.37e-02 58 2 1 0.500 0.017 REAC:5610780 rea 1 Degradation of GLI1 by the proteasome 1 Q9UMX1 58 2.41e-02 59 2 1 0.500 0.017 REAC:5610785 rea 1 GLI3 is processed to GLI3R by the proteasome 1 Q9UMX1 58 2.59e-02 15 2 1 0.500 0.067 GO:0042994 BP 1 cytoplasmic sequestering of transcription factor 1 Q9UMX1 58 2.60e-02 141 2 1 0.500 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 Q9UMX1 58 2.76e-02 16 2 1 0.500 0.062 GO:0007218 BP 1 neuropeptide signaling pathway 1 O95157 58 2.93e-02 17 2 1 0.500 0.059 GO:0097546 CC 1 ciliary base 1 Q9UMX1 58 3.00e-02 3 2 1 0.500 0.333 OMIM:109400 omi 1 BASAL CELL NEVUS SYNDROME; BCNS;;GORLIN SYNDROME;;GORLIN-GOLTZ SYNDROME;;NEVOID BASAL CELL CARCINOMA SYNDROME; NBCCS;;MULTIPLE BASAL CELL NEVI, ODONTOGENIC KERATOCYSTS, AND SKELETAL ANOMALIES 1 Q9UMX1 58 3.00e-02 3 2 1 0.500 0.333 OMIM:155255 omi 1 MEDULLOBLASTOMA; MDBMEDULLOBLASTOMA, DESMOPLASTIC, INCLUDED;;MEDULLOBLASTOMA WITH EXTENSIVE NODULARITY, INCLUDED; MBEN, INCLUDED 1 Q9UMX1 58 3.06e-02 75 2 1 0.500 0.013 REAC:5632684 rea 1 Hedgehog 'on' state 1 Q9UMX1 58 3.10e-02 18 2 1 0.500 0.056 GO:0045668 BP 1 negative regulation of osteoblast differentiation 1 Q9UMX1 58 3.23e-02 565 2 2 1.000 0.004 TF:M07402_0 tf 1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 0 1 Q9UMX1,O95157 58 3.28e-02 19 2 1 0.500 0.053 GO:0008589 BP 1 regulation of smoothened signaling pathway 1 Q9UMX1 58 3.95e-02 97 2 1 0.500 0.010 REAC:5610787 rea 1 Hedgehog 'off' state 1 Q9UMX1 58 4.64e-02 18 2 1 0.500 0.056 TF:M05919_0 tf 1 Factor: ZIM3; motif: ATTAGGWAGWGS; match class: 0 1 Q9UMX1 58 4.66e-02 27 2 1 0.500 0.037 GO:0042992 BP 1 negative regulation of transcription factor import into nucleus 1 Q9UMX1 58 5.00e-02 29 2 1 0.500 0.034 GO:0030279 BP 1 negative regulation of ossification 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0005449 hp 1 Bridged sella turcica 1 Q9UMX1 58 5.00e-02 37 2 1 0.500 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0010617 hp 1 Cardiac fibroma 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0004795 hp 1 Hamartomatous stomach polyps 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0009650 hp 1 Short distal phalanx of the thumb 1 Q9UMX1 58 5.00e-02 5 2 1 0.500 0.200 OMIM:607174 omi 1 MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO 1 Q9UMX1 58 5.00e-02 123 2 1 0.500 0.008 REAC:5358351 rea 1 Signaling by Hedgehog 1 Q9UMX1 58 5.00e-02 29 2 1 0.500 0.034 GO:0051220 BP 1 cytoplasmic sequestering of protein 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0001144 hp 1 Orbital cyst 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0009641 hp 1 Aplasia/Hypoplasia of the distal phalanx of the thumb 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0010618 hp 1 Ovarian fibroma 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0010603 hp 1 Odontogenic keratocysts of the jaw 1 Q9UMX1 58 5.00e-02 3 2 1 0.500 0.333 HP:0004280 hp 1 Irregular ossification of hand bones 1 Q9UMX1 58 5.00e-02 703 2 2 1.000 0.003 TF:M01854_1 tf 1 Factor: AML2; motif: CCRCACCAYDN; match class: 1 1 Q9UMX1,O95157 58 5.00e-02 37 2 1 0.500 0.027 KEGG:05217 keg 1 Basal cell carcinoma 1 Q9UMX1 59 6.91e-03 25 2 1 0.500 0.040 REAC:5673000 rea 1 RAF activation 1 P27448 59 9.66e-03 35 2 1 0.500 0.029 REAC:5675221 rea 1 Negative regulation of MAPK pathway 1 P27448 59 1.02e-02 37 2 1 0.500 0.027 REAC:5674135 rea 1 MAP2K and MAPK activation 1 P27448 59 1.36e-02 329 2 2 1.000 0.006 GO:0004674 MF 1 protein serine/threonine kinase activity 1 P27448,P11309 59 1.46e-02 5 2 1 0.500 0.200 GO:0070561 BP 1 vitamin D receptor signaling pathway 1 P11309 59 1.75e-02 6 2 1 0.500 0.167 GO:0071305 BP 1 cellular response to vitamin D 1 P11309 59 2.33e-02 8 2 1 0.500 0.125 GO:0071295 BP 1 cellular response to vitamin 1 P11309 59 2.62e-02 9 2 1 0.500 0.111 GO:0033280 BP 1 response to vitamin D 1 P11309 59 2.81e-02 472 2 2 1.000 0.004 GO:0004672 MF 1 protein kinase activity 1 P27448,P11309 59 3.18e-02 52 2 1 0.500 0.019 KEGG:05221 keg 1 Acute myeloid leukemia 1 P11309 59 3.49e-02 12 2 1 0.500 0.083 GO:0043024 MF 1 ribosomal small subunit binding 1 P11309 59 3.78e-02 13 2 1 0.500 0.077 GO:0033273 BP 1 response to vitamin 1 P11309 59 4.07e-02 14 2 1 0.500 0.071 GO:0031670 BP 1 cellular response to nutrient 1 P11309 59 4.21e-02 578 2 2 1.000 0.003 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P27448,P11309 59 5.00e-02 82 2 1 0.500 0.012 KEGG:04630 keg 1 Jak-STAT signaling pathway 1 P11309 59 5.00e-02 630 2 2 1.000 0.003 GO:0016301 MF 1 kinase activity 1 P27448,P11309 60 6.79e-16 8 6 5 0.833 0.625 GO:0000808 CC 1 origin recognition complex 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 6.79e-16 8 6 5 0.833 0.625 GO:0005664 CC 1 nuclear origin of replication recognition complex 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.72e-12 30 6 5 0.833 0.167 GO:0006270 BP 1 DNA replication initiation 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 6.67e-12 6 6 4 0.667 0.667 REAC:68616 rea 1 Assembly of the ORC complex at the origin of replication 1 Q13415,Q9Y5N6,Q13416,O43913 60 9.33e-11 10 6 4 0.667 0.400 REAC:113507 rea 1 E2F-enabled inhibition of pre-replication complex formation 1 Q13415,Q9Y5N6,Q13416,O43913 60 1.47e-10 11 6 4 0.667 0.364 REAC:68689 rea 1 CDC6 association with the ORC:origin complex 1 Q13415,Q9Y5N6,Q13416,O43913 60 9.29e-10 6 6 4 0.667 0.667 CORUM:1033 cor 1 ORC complex (origin recognition complex) 1 Q13415,Q9Y5N6,Q13416,O43913 60 9.29e-10 6 6 4 0.667 0.667 CORUM:1031 cor 1 ORC complex (origin recognition complex) 1 Q13415,Q9Y5N6,Q13416,O43913 60 9.29e-10 6 6 4 0.667 0.667 CORUM:389 cor 1 ORC complex (origin recognition complex) 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.20e-09 119 6 5 0.833 0.042 GO:0006261 BP 1 DNA-dependent DNA replication 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.39e-08 31 6 4 0.667 0.129 REAC:68962 rea 1 Activation of the pre-replicative complex 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.05e-08 34 6 4 0.667 0.118 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.25e-08 9 6 3 0.500 0.333 GO:0003688 MF 1 DNA replication origin binding 1 Q9Y5N6,Q13416,O43913 60 2.60e-08 36 6 4 0.667 0.111 REAC:176187 rea 1 Activation of ATR in response to replication stress 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.57e-08 217 6 5 0.833 0.023 GO:0006260 BP 1 DNA replication 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.86e-07 58 6 4 0.667 0.069 REAC:68827 rea 1 CDT1 association with the CDC6:ORC:origin complex 1 Q13415,Q9Y5N6,Q13416,O43913 60 3.36e-07 67 6 4 0.667 0.060 REAC:68867 rea 1 Assembly of the pre-replicative complex 1 Q13415,Q9Y5N6,Q13416,O43913 60 3.88e-07 14 6 3 0.500 0.214 REAC:69298 rea 1 Association of licensing factors with the pre-replicative complex 1 Q13415,Q13416,O43913 60 4.02e-07 70 6 4 0.667 0.057 REAC:69052 rea 1 Switching of origins to a post-replicative state 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.02e-07 70 6 4 0.667 0.057 REAC:68949 rea 1 Orc1 removal from chromatin 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.28e-07 112 6 4 0.667 0.036 GO:0000781 CC 1 chromosome, telomeric region 1 Q13415,Q13416,Q9UFC0,O43913 60 4.51e-07 72 6 4 0.667 0.056 REAC:69300 rea 1 Removal of licensing factors from origins 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.74e-07 5 6 3 0.500 0.600 CORUM:1038 cor 1 ORC 1-5 complex (origin recognition 1-5 complex) 1 Q13415,Q13416,O43913 60 5.32e-07 75 6 4 0.667 0.053 REAC:69304 rea 1 Regulation of DNA replication 1 Q13415,Q9Y5N6,Q13416,O43913 60 5.55e-07 357 6 5 0.833 0.014 GO:0044454 CC 1 nuclear chromosome part 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 7.89e-07 383 6 5 0.833 0.013 GO:0000228 CC 1 nuclear chromosome 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 8.03e-07 83 6 4 0.667 0.048 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 Q13415,Q9Y5N6,Q13416,O43913 60 8.03e-07 83 6 4 0.667 0.048 REAC:68874 rea 1 M/G1 Transition 1 Q13415,Q9Y5N6,Q13416,O43913 60 1.64e-06 99 6 4 0.667 0.040 REAC:69239 rea 1 Synthesis of DNA 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.16e-06 106 6 4 0.667 0.038 REAC:69306 rea 1 DNA Replication 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.76e-06 178 6 4 0.667 0.022 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 Q13415,Q9Y5N6,Q13416,O43913 60 3.00e-06 115 6 4 0.667 0.035 REAC:69206 rea 1 G1/S Transition 1 Q13415,Q9Y5N6,Q13416,O43913 60 3.22e-06 185 6 4 0.667 0.022 GO:0044843 BP 1 cell cycle G1/S phase transition 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.33e-06 126 6 4 0.667 0.032 REAC:69242 rea 1 S Phase 1 Q13415,Q9Y5N6,Q13416,O43913 60 5.48e-06 565 6 5 0.833 0.009 GO:0044427 CC 1 chromosomal part 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 6.24e-06 138 6 4 0.667 0.029 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 Q13415,Q9Y5N6,Q13416,O43913 60 7.20e-06 143 6 4 0.667 0.028 REAC:69481 rea 1 G2/M Checkpoints 1 Q13415,Q9Y5N6,Q13416,O43913 60 7.69e-06 230 6 4 0.667 0.017 GO:0098687 CC 1 chromosomal region 1 Q13415,Q13416,Q9UFC0,O43913 60 7.96e-06 609 6 5 0.833 0.008 GO:0005694 CC 1 chromosome 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.28e-05 670 6 5 0.833 0.007 GO:0006259 BP 1 DNA metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.58e-05 174 6 4 0.667 0.023 REAC:69620 rea 1 Cell Cycle Checkpoints 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.73e-05 2 6 2 0.333 1.000 CORUM:2205 cor 1 ORC5-ORC1 complex 1 Q13415,O43913 60 4.26e-05 100 6 3 0.500 0.030 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 Q13415,Q13416,O43913 60 6.22e-05 922 6 5 0.833 0.005 GO:0003677 MF 1 DNA binding 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 7.73e-05 411 6 4 0.667 0.010 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q13415,Q9Y5N6,Q13416,O43913 60 8.83e-05 425 6 4 0.667 0.009 GO:0044770 BP 1 cell cycle phase transition 1 Q13415,Q9Y5N6,Q13416,O43913 60 1.35e-04 473 6 4 0.667 0.008 GO:0043565 MF 1 sequence-specific DNA binding 1 Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.63e-04 5 6 2 0.333 0.400 HP:0006591 hp 1 Absent glenoid fossa 1 Q13415,Q9Y5N6 60 1.63e-04 4 6 2 0.333 0.500 CORUM:1034 cor 1 ORC 2-5 complex (origin recognition 2-5 complex) 1 Q13416,O43913 60 2.44e-04 6 6 2 0.333 0.333 HP:0006628 hp 1 Absent sternal ossification 1 Q13415,Q9Y5N6 60 2.44e-04 6 6 2 0.333 0.333 HP:0000911 hp 1 Flat glenoid fossa 1 Q13415,Q9Y5N6 60 3.41e-04 7 6 2 0.333 0.286 HP:0000385 hp 1 Small earlobe 1 Q13415,Q9Y5N6 60 4.07e-04 6 6 2 0.333 0.333 CORUM:5251 cor 1 Ku-ORC complex 1 Q9Y5N6,Q13416 60 4.54e-04 8 6 2 0.333 0.250 HP:0000064 hp 1 Hypoplastic labia minora 1 Q13415,Q9Y5N6 60 4.54e-04 8 6 2 0.333 0.250 HP:0040252 hp 1 Abnormal size of the clitoris 1 Q13415,Q9Y5N6 60 4.54e-04 8 6 2 0.333 0.250 HP:0008665 hp 1 Clitoral hypertrophy 1 Q13415,Q9Y5N6 60 4.54e-04 8 6 2 0.333 0.250 HP:0011912 hp 1 Abnormality of the glenoid fossa 1 Q13415,Q9Y5N6 60 4.54e-04 8 6 2 0.333 0.250 HP:0040253 hp 1 Increased size of the clitoris 1 Q13415,Q9Y5N6 60 4.90e-04 657 6 4 0.667 0.006 GO:1903047 BP 1 mitotic cell cycle process 1 Q13415,Q9Y5N6,Q13416,O43913 60 5.69e-04 39 6 2 0.333 0.051 GO:0000792 CC 1 heterochromatin 1 Q13416,Q9UFC0 60 6.66e-04 448 6 4 0.667 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q13415,Q9Y5N6,Q13416,O43913 60 7.05e-04 721 6 4 0.667 0.006 GO:0000278 BP 1 mitotic cell cycle 1 Q13415,Q9Y5N6,Q13416,O43913 60 7.28e-04 10 6 2 0.333 0.200 HP:0011863 hp 1 Abnormal sternal ossification 1 Q13415,Q9Y5N6 60 7.28e-04 10 6 2 0.333 0.200 HP:0003187 hp 1 Breast hypoplasia 1 Q13415,Q9Y5N6 60 7.28e-04 10 6 2 0.333 0.200 HP:0003561 hp 1 Birth length less than 3rd percentile 1 Q13415,Q9Y5N6 60 8.89e-04 11 6 2 0.333 0.182 HP:0006361 hp 1 Irregular femoral epiphysis 1 Q13415,Q9Y5N6 60 9.75e-04 5 6 2 0.333 0.400 OMIM:224690 omi 1 Meier-Gorlin Syndrome 1 Q13415,Q9Y5N6 60 1.26e-03 13 6 2 0.333 0.154 HP:0003090 hp 1 Hypoplasia of the capital femoral epiphysis 1 Q13415,Q9Y5N6 60 1.26e-03 13 6 2 0.333 0.154 HP:0002780 hp 1 Bronchomalacia 1 Q13415,Q9Y5N6 60 1.42e-03 324 6 3 0.500 0.009 GO:1990837 MF 1 sequence-specific double-stranded DNA binding 1 Q9Y5N6,Q13416,O43913 60 1.45e-03 547 6 4 0.667 0.007 REAC:1640170 rea 1 Cell Cycle 1 Q13415,Q9Y5N6,Q13416,O43913 60 1.47e-03 14 6 2 0.333 0.143 HP:0000237 hp 1 Small anterior fontanelle 1 Q13415,Q9Y5N6 60 1.47e-03 14 6 2 0.333 0.143 HP:0001795 hp 1 Hyperconvex nail 1 Q13415,Q9Y5N6 60 1.69e-03 15 6 2 0.333 0.133 HP:0012880 hp 1 Abnormality of the labia minora 1 Q13415,Q9Y5N6 60 1.69e-03 15 6 2 0.333 0.133 HP:0005003 hp 1 Aplasia/Hypoplasia of the capital femoral epiphysis 1 Q13415,Q9Y5N6 60 1.69e-03 15 6 2 0.333 0.133 HP:0010577 hp 1 Absent epiphyses 1 Q13415,Q9Y5N6 60 1.69e-03 15 6 2 0.333 0.133 HP:0000056 hp 1 Abnormality of the clitoris 1 Q13415,Q9Y5N6 60 2.08e-03 952 6 4 0.667 0.004 GO:0022402 BP 1 cell cycle process 1 Q13415,Q9Y5N6,Q13416,O43913 60 2.19e-03 17 6 2 0.333 0.118 HP:0000049 hp 1 Shawl scrotum 1 Q13415,Q9Y5N6 60 2.33e-03 384 6 3 0.500 0.008 GO:0003690 MF 1 double-stranded DNA binding 1 Q9Y5N6,Q13416,O43913 60 2.46e-03 18 6 2 0.333 0.111 HP:0100783 hp 1 Breast aplasia 1 Q13415,Q9Y5N6 60 2.50e-03 1960 6 5 0.833 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 2.50e-03 1960 6 5 0.833 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 3.04e-03 20 6 2 0.333 0.100 HP:0000059 hp 1 Hypoplastic labia majora 1 Q13415,Q9Y5N6 60 3.04e-03 20 6 2 0.333 0.100 HP:0002779 hp 1 Tracheomalacia 1 Q13415,Q9Y5N6 60 3.04e-03 20 6 2 0.333 0.100 HP:0006443 hp 1 Patellar aplasia 1 Q13415,Q9Y5N6 60 3.36e-03 21 6 2 0.333 0.095 HP:0000895 hp 1 Lateral clavicle hook 1 Q13415,Q9Y5N6 60 3.36e-03 21 6 2 0.333 0.095 HP:0012881 hp 1 Abnormality of the labia majora 1 Q13415,Q9Y5N6 60 3.45e-03 2096 6 5 0.833 0.002 GO:0043234 CC 1 protein complex 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 3.69e-03 22 6 2 0.333 0.091 HP:0006498 hp 1 Aplasia/Hypoplasia of the patella 1 Q13415,Q9Y5N6 60 3.69e-03 22 6 2 0.333 0.091 HP:0010311 hp 1 Aplasia/Hypoplasia of the breasts 1 Q13415,Q9Y5N6 60 3.78e-03 2136 6 5 0.833 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 3.99e-03 1128 6 4 0.667 0.004 GO:0007049 BP 1 cell cycle 1 Q13415,Q9Y5N6,Q13416,O43913 60 4.78e-03 25 6 2 0.333 0.080 HP:0000066 hp 1 Labial hypoplasia 1 Q13415,Q9Y5N6 60 4.78e-03 25 6 2 0.333 0.080 HP:0005487 hp 1 Prominent metopic ridge 1 Q13415,Q9Y5N6 60 5.18e-03 26 6 2 0.333 0.077 HP:0012815 hp 1 Hypoplastic female external genitalia 1 Q13415,Q9Y5N6 60 5.18e-03 26 6 2 0.333 0.077 HP:0010582 hp 1 Irregular epiphyses 1 Q13415,Q9Y5N6 60 5.58e-03 27 6 2 0.333 0.074 HP:0006714 hp 1 Aplasia/Hypoplasia of the sternum 1 Q13415,Q9Y5N6 60 6.01e-03 28 6 2 0.333 0.071 HP:0002970 hp 1 Genu varum 1 Q13415,Q9Y5N6 60 6.45e-03 29 6 2 0.333 0.069 HP:0005556 hp 1 Abnormality of the metopic suture 1 Q13415,Q9Y5N6 60 6.90e-03 30 6 2 0.333 0.067 HP:0002816 hp 1 Genu recurvatum 1 Q13415,Q9Y5N6 60 6.90e-03 30 6 2 0.333 0.067 HP:0010458 hp 1 Female pseudohermaphroditism 1 Q13415,Q9Y5N6 60 7.14e-03 4 6 1 0.167 0.250 GO:0031933 CC 1 telomeric heterochromatin 1 Q9UFC0 60 7.52e-03 259 6 2 0.333 0.008 MI:hsa-miR-191* mi 1 MI:hsa-miR-191* 1 Q13415,Q9Y5N6 60 7.58e-03 2 6 1 0.167 0.500 TF:M06718_0 tf 1 Factor: ZNF624; motif: NTGTATGGATSC; match class: 0 1 Q13416 60 7.85e-03 32 6 2 0.333 0.062 HP:0009906 hp 1 Aplasia/Hypoplasia of the earlobes 1 Q13415,Q9Y5N6 60 7.85e-03 32 6 2 0.333 0.062 HP:0000883 hp 1 Thin ribs 1 Q13415,Q9Y5N6 60 7.85e-03 32 6 2 0.333 0.062 HP:0010554 hp 1 Cutaneous finger syndactyly 1 Q13415,Q9Y5N6 60 8.35e-03 33 6 2 0.333 0.061 HP:0002937 hp 1 Hemivertebrae 1 Q13415,Q9Y5N6 60 8.86e-03 34 6 2 0.333 0.059 HP:0002097 hp 1 Emphysema 1 Q13415,Q9Y5N6 60 9.39e-03 35 6 2 0.333 0.057 HP:0012725 hp 1 Cutaneous syndactyly 1 Q13415,Q9Y5N6 60 9.93e-03 2612 6 5 0.833 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.05e-02 37 6 2 0.333 0.054 HP:0003100 hp 1 Slender long bone 1 Q13415,Q9Y5N6 60 1.05e-02 37 6 2 0.333 0.054 HP:0000046 hp 1 Scrotal hypoplasia 1 Q13415,Q9Y5N6 60 1.05e-02 37 6 2 0.333 0.054 HP:0000308 hp 1 Microretrognathia 1 Q13415,Q9Y5N6 60 1.05e-02 37 6 2 0.333 0.054 HP:0000058 hp 1 Abnormality of the labia 1 Q13415,Q9Y5N6 60 1.08e-02 2660 6 5 0.833 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.16e-02 39 6 2 0.333 0.051 HP:0002812 hp 1 Coxa vara 1 Q13415,Q9Y5N6 60 1.16e-02 39 6 2 0.333 0.051 HP:0010574 hp 1 Abnormality of the epiphysis of the femoral head 1 Q13415,Q9Y5N6 60 1.22e-02 40 6 2 0.333 0.050 HP:0010306 hp 1 Short thorax 1 Q13415,Q9Y5N6 60 1.22e-02 40 6 2 0.333 0.050 HP:0006499 hp 1 Abnormality of femoral epiphysis 1 Q13415,Q9Y5N6 60 1.25e-02 7 6 1 0.167 0.143 GO:0071169 BP 1 establishment of protein localization to chromatin 1 Q9UFC0 60 1.29e-02 41 6 2 0.333 0.049 HP:0006500 hp 1 Abnormality of lower limb epiphysis morphology 1 Q13415,Q9Y5N6 60 1.31e-02 2770 6 5 0.833 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.35e-02 42 6 2 0.333 0.048 HP:0001623 hp 1 Breech presentation 1 Q13415,Q9Y5N6 60 1.35e-02 351 6 2 0.333 0.006 MI:hsa-miR-614 mi 1 MI:hsa-miR-614 1 O43913,Q96ND0 60 1.41e-02 43 6 2 0.333 0.047 HP:0001620 hp 1 High pitched voice 1 Q13415,Q9Y5N6 60 1.55e-02 2869 6 5 0.833 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.61e-02 9 6 1 0.167 0.111 GO:0005721 CC 1 pericentric heterochromatin 1 Q9UFC0 60 1.62e-02 46 6 2 0.333 0.043 HP:0003043 hp 1 Abnormality of the shoulder 1 Q13415,Q9Y5N6 60 1.72e-02 2931 6 5 0.833 0.002 GO:0031981 CC 1 nuclear lumen 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.74e-02 400 6 2 0.333 0.005 MI:hsa-miR-640 mi 1 MI:hsa-miR-640 1 Q13415,Q9Y5N6 60 1.76e-02 48 6 2 0.333 0.042 HP:0000527 hp 1 Long eyelashes 1 Q13415,Q9Y5N6 60 1.76e-02 48 6 2 0.333 0.042 HP:0000773 hp 1 Short ribs 1 Q13415,Q9Y5N6 60 1.76e-02 48 6 2 0.333 0.042 HP:0003045 hp 1 Abnormality of the patella 1 Q13415,Q9Y5N6 60 1.83e-02 49 6 2 0.333 0.041 HP:0003368 hp 1 Abnormality of the femoral head 1 Q13415,Q9Y5N6 60 1.90e-02 50 6 2 0.333 0.040 HP:0000376 hp 1 Incomplete partition of the cochlea type II 1 Q13415,Q9Y5N6 60 1.90e-02 50 6 2 0.333 0.040 HP:0011373 hp 1 Incomplete partition of the cochlea 1 Q13415,Q9Y5N6 60 1.91e-02 421 6 2 0.333 0.005 MI:hsa-miR-603 mi 1 MI:hsa-miR-603 1 Q13416,Q96ND0 60 1.96e-02 3013 6 5 0.833 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 1.97e-02 428 6 2 0.333 0.005 MI:hsa-miR-25 mi 1 MI:hsa-miR-25 1 Q13415,Q13416 60 2.05e-02 437 6 2 0.333 0.005 MI:hsa-miR-302d* mi 1 MI:hsa-miR-302d* 1 Q13415,Q96ND0 60 2.06e-02 52 6 2 0.333 0.038 HP:0008554 hp 1 Cochlear malformation 1 Q13415,Q9Y5N6 60 2.09e-02 441 6 2 0.333 0.005 MI:hsa-miR-10a mi 1 MI:hsa-miR-10a 1 Q13415,O43913 60 2.10e-02 442 6 2 0.333 0.005 MI:hsa-miR-182 mi 1 MI:hsa-miR-182 1 Q13415,O43913 60 2.12e-02 444 6 2 0.333 0.005 MI:hsa-miR-383 mi 1 MI:hsa-miR-383 1 Q13415,O43913 60 2.14e-02 12 6 1 0.167 0.083 GO:0071168 BP 1 protein localization to chromatin 1 Q9UFC0 60 2.22e-02 455 6 2 0.333 0.004 MI:mmu-miR-714 mi 1 MI:mmu-miR-714 1 Q9Y5N6,O43913 60 2.33e-02 467 6 2 0.333 0.004 MI:hsa-miR-891a mi 1 MI:hsa-miR-891a 1 Q13415,Q96ND0 60 2.38e-02 56 6 2 0.333 0.036 HP:0000963 hp 1 Thin skin 1 Q13415,Q9Y5N6 60 2.40e-02 475 6 2 0.333 0.004 MI:hsa-miR-196b mi 1 MI:hsa-miR-196b 1 O43913,Q96ND0 60 2.45e-02 480 6 2 0.333 0.004 MI:hsa-miR-450a mi 1 MI:hsa-miR-450a 1 Q9UFC0,O43913 60 2.46e-02 57 6 2 0.333 0.035 HP:0001787 hp 1 Abnormal delivery 1 Q13415,Q9Y5N6 60 2.47e-02 482 6 2 0.333 0.004 MI:hsa-miR-191 mi 1 MI:hsa-miR-191 1 Q13415,Q9Y5N6 60 2.48e-02 3168 6 5 0.833 0.002 GO:0044428 CC 1 nuclear part 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 2.53e-02 488 6 2 0.333 0.004 MI:hsa-miR-155 mi 1 MI:hsa-miR-155 1 Q9Y5N6,Q96ND0 60 2.66e-02 501 6 2 0.333 0.004 MI:hsa-miR-196a mi 1 MI:hsa-miR-196a 1 O43913,Q96ND0 60 2.81e-02 61 6 2 0.333 0.033 HP:0000413 hp 1 Atresia of the external auditory canal 1 Q13415,Q9Y5N6 60 2.85e-02 16 6 1 0.167 0.062 GO:0008327 MF 1 methyl-CpG binding 1 Q9UFC0 60 2.90e-02 62 6 2 0.333 0.032 HP:0012745 hp 1 Short palpebral fissure 1 Q13415,Q9Y5N6 60 3.09e-02 64 6 2 0.333 0.031 HP:0006532 hp 1 Recurrent pneumonia 1 Q13415,Q9Y5N6 60 3.09e-02 64 6 2 0.333 0.031 HP:0000327 hp 1 Hypoplasia of the maxilla 1 Q13415,Q9Y5N6 60 3.12e-02 294 6 2 0.333 0.007 GO:0000785 CC 1 chromatin 1 Q13416,Q9UFC0 60 3.53e-02 3415 6 5 0.833 0.001 GO:0032991 CC 1 macromolecular complex 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 3.66e-02 3443 6 5 0.833 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 3.67e-02 1785 6 4 0.667 0.002 TF:M00626_1 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 1 1 Q13415,Q9Y5N6,O43913,Q96ND0 60 3.68e-02 70 6 2 0.333 0.029 HP:0000326 hp 1 Abnormality of the maxilla 1 Q13415,Q9Y5N6 60 3.68e-02 70 6 2 0.333 0.029 HP:0000045 hp 1 Abnormality of the scrotum 1 Q13415,Q9Y5N6 60 3.75e-02 3 6 1 0.167 0.333 CORUM:1032 cor 1 ORC 2-4 complex (origin recognition 2-4 complex) 1 Q13416 60 3.75e-02 3 6 1 0.167 0.333 CORUM:2204 cor 1 MCM8-ORC2-CDC6 complex 1 Q13416 60 3.78e-02 71 6 2 0.333 0.028 HP:0000319 hp 1 Smooth philtrum 1 Q13415,Q9Y5N6 60 3.78e-02 71 6 2 0.333 0.028 HP:0003042 hp 1 Elbow dislocation 1 Q13415,Q9Y5N6 60 3.78e-02 71 6 2 0.333 0.028 HP:0200055 hp 1 Small hand 1 Q13415,Q9Y5N6 60 3.78e-02 10 6 1 0.167 0.100 TF:M06406_0 tf 1 Factor: ZNF534; motif: NTGTCAAGCTGC; match class: 0 1 Q13415 60 3.79e-02 827 6 3 0.500 0.004 TF:M01251_1 tf 1 Factor: E2F-1; motif: CGAAAMGT; match class: 1 1 Q13416,O43913,Q96ND0 60 3.88e-02 834 6 3 0.500 0.004 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 Q9Y5N6,O43913,Q96ND0 60 3.89e-02 72 6 2 0.333 0.028 HP:0000372 hp 1 Abnormality of the auditory canal 1 Q13415,Q9Y5N6 60 3.89e-02 72 6 2 0.333 0.028 HP:0030310 hp 1 Upper extremity joint dislocation 1 Q13415,Q9Y5N6 60 3.91e-02 22 6 1 0.167 0.045 GO:0070199 BP 1 establishment of protein localization to chromosome 1 Q9UFC0 60 3.91e-02 22 6 1 0.167 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 Q13415 60 3.95e-02 3499 6 5 0.833 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.21e-02 75 6 2 0.333 0.027 HP:0000375 hp 1 Abnormality of cochlea 1 Q13415,Q9Y5N6 60 4.25e-02 3554 6 5 0.833 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.29e-02 3561 6 5 0.833 0.001 GO:0043233 CC 1 organelle lumen 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.29e-02 3561 6 5 0.833 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.29e-02 3561 6 5 0.833 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.29e-02 3561 6 5 0.833 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.33e-02 3569 6 5 0.833 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.43e-02 77 6 2 0.333 0.026 HP:0011390 hp 1 Morphological abnormality of the inner ear 1 Q13415,Q9Y5N6 60 4.43e-02 77 6 2 0.333 0.026 HP:0002783 hp 1 Recurrent lower respiratory tract infections 1 Q13415,Q9Y5N6 60 4.43e-02 77 6 2 0.333 0.026 HP:0006505 hp 1 Abnormality of limb epiphysis morphology 1 Q13415,Q9Y5N6 60 4.48e-02 1883 6 4 0.667 0.002 TF:M04505_0 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 0 1 Q13415,Q9Y5N6,O43913,Q96ND0 60 4.48e-02 1883 6 4 0.667 0.002 TF:M04623_0 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 0 1 Q13415,Q9Y5N6,O43913,Q96ND0 60 4.54e-02 78 6 2 0.333 0.026 HP:0000889 hp 1 Abnormality of the clavicle 1 Q13415,Q9Y5N6 60 4.63e-02 3620 6 5 0.833 0.001 GO:0009058 BP 1 biosynthetic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 4.77e-02 80 6 2 0.333 0.025 HP:0000236 hp 1 Abnormality of the anterior fontanelle 1 Q13415,Q9Y5N6 60 4.77e-02 80 6 2 0.333 0.025 HP:0004279 hp 1 Short palm 1 Q13415,Q9Y5N6 60 4.80e-02 27 6 1 0.167 0.037 GO:0016235 CC 1 aggresome 1 Q9Y5N6 60 4.88e-02 81 6 2 0.333 0.025 HP:0002109 hp 1 Abnormality of the bronchi 1 Q13415,Q9Y5N6 60 5.00e-02 117 6 4 0.667 0.034 KEGG:04110 keg 1 Cell cycle 1 Q13415,Q9Y5N6,Q13416,O43913 60 5.00e-02 3387 6 5 0.833 0.001 TF:M07352_0 tf 1 Factor: Crx; motif: NYTAATCNN; match class: 0 1 Q13415,Q9Y5N6,Q13416,O43913,Q96ND0 60 5.00e-02 1 6 1 0.167 1.000 OMIM:613803 omi 1 MEIER-GORLIN SYNDROME 3; MGORS3 1 Q9Y5N6 60 5.00e-02 18 6 1 0.167 0.056 REAC:69205 rea 1 G1/S-Specific Transcription 1 Q13415 60 5.00e-02 82 6 2 0.333 0.024 HP:0000430 hp 1 Underdeveloped nasal alae 1 Q13415,Q9Y5N6 60 5.00e-02 3387 6 5 0.833 0.001 TF:M04429_0 tf 1 Factor: PITX3; motif: NNTAATCCN; match class: 0 1 Q13415,Q9Y5N6,Q13416,O43913,Q96ND0 60 5.00e-02 3681 6 5 0.833 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q13415,Q9Y5N6,Q13416,Q9UFC0,O43913 60 5.00e-02 4 6 1 0.167 0.250 CORUM:2210 cor 1 BRCA1-IRIS-pre-replication complex 1 Q13415 61 5.68e-07 4 7 3 0.429 0.750 CORUM:190 cor 1 Mitotic checkpoint complex (MCC) 1 Q12834,O43684,O60566 61 7.59e-07 19 7 3 0.429 0.158 REAC:141405 rea 1 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 1 Q12834,O43684,O60566 61 7.59e-07 19 7 3 0.429 0.158 REAC:141430 rea 1 Inactivation of APC/C via direct inhibition of the APC/C complex 1 Q12834,O43684,O60566 61 8.92e-07 20 7 3 0.429 0.150 REAC:69618 rea 1 Mitotic Spindle Checkpoint 1 Q12834,O43684,O60566 61 1.38e-06 23 7 3 0.429 0.130 REAC:179409 rea 1 APC-Cdc20 mediated degradation of Nek2A 1 Q12834,O43684,O60566 61 1.93e-05 68 7 3 0.429 0.044 GO:0051436 BP 1 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1 Q12834,O43684,O60566 61 2.02e-05 69 7 3 0.429 0.043 GO:0051439 BP 1 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1 Q12834,O43684,O60566 61 2.02e-05 69 7 3 0.429 0.043 GO:1904667 BP 1 negative regulation of ubiquitin protein ligase activity 1 Q12834,O43684,O60566 61 2.49e-05 74 7 3 0.429 0.041 GO:0051437 BP 1 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition 1 Q12834,O43684,O60566 61 2.49e-05 74 7 3 0.429 0.041 GO:0051444 BP 1 negative regulation of ubiquitin-protein transferase activity 1 Q12834,O43684,O60566 61 2.81e-05 77 7 3 0.429 0.039 GO:0031145 BP 1 anaphase-promoting complex-dependent catabolic process 1 Q12834,O43684,O60566 61 2.81e-05 77 7 3 0.429 0.039 GO:1904668 BP 1 positive regulation of ubiquitin protein ligase activity 1 Q12834,O43684,O60566 61 3.04e-05 79 7 3 0.429 0.038 GO:1904666 BP 1 regulation of ubiquitin protein ligase activity 1 Q12834,O43684,O60566 61 3.52e-05 83 7 3 0.429 0.036 GO:2000060 BP 1 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q12834,O43684,O60566 61 4.20e-05 70 7 3 0.429 0.043 REAC:174184 rea 1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1 Q12834,O43684,O60566 61 4.35e-05 89 7 3 0.429 0.034 GO:2000058 BP 1 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q12834,O43684,O60566 61 4.38e-05 71 7 3 0.429 0.042 REAC:179419 rea 1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 1 Q12834,O43684,O60566 61 4.65e-05 91 7 3 0.429 0.033 GO:0051443 BP 1 positive regulation of ubiquitin-protein transferase activity 1 Q12834,O43684,O60566 61 4.76e-05 73 7 3 0.429 0.041 REAC:176409 rea 1 APC/C:Cdc20 mediated degradation of mitotic proteins 1 Q12834,O43684,O60566 61 4.96e-05 74 7 3 0.429 0.041 REAC:176814 rea 1 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1 Q12834,O43684,O60566 61 5.81e-05 78 7 3 0.429 0.038 REAC:176408 rea 1 Regulation of APC/C activators between G1/S and early anaphase 1 Q12834,O43684,O60566 61 6.75e-05 103 7 3 0.429 0.029 GO:0051438 BP 1 regulation of ubiquitin-protein transferase activity 1 Q12834,O43684,O60566 61 7.26e-05 84 7 3 0.429 0.036 REAC:453276 rea 1 Regulation of mitotic cell cycle 1 Q12834,O43684,O60566 61 7.26e-05 84 7 3 0.429 0.036 REAC:174143 rea 1 APC/C-mediated degradation of cell cycle proteins 1 Q12834,O43684,O60566 61 7.78e-05 108 7 3 0.429 0.028 GO:0031397 BP 1 negative regulation of protein ubiquitination 1 Q12834,O43684,O60566 61 8.91e-05 113 7 3 0.429 0.027 GO:1903321 BP 1 negative regulation of protein modification by small protein conjugation or removal 1 Q12834,O43684,O60566 61 9.64e-05 116 7 3 0.429 0.026 GO:0007062 BP 1 sister chromatid cohesion 1 Q12834,O43684,O60566 61 1.19e-04 99 7 3 0.429 0.030 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q12834,O43684,O60566 61 1.42e-04 1635 7 6 0.857 0.004 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 1.50e-04 107 7 3 0.429 0.028 REAC:68877 rea 1 Mitotic Prometaphase 1 Q12834,O43684,O60566 61 1.62e-04 138 7 3 0.429 0.022 GO:1903052 BP 1 positive regulation of proteolysis involved in cellular protein catabolic process 1 Q12834,O43684,O60566 61 1.71e-04 20 7 2 0.286 0.100 GO:0005680 CC 1 anaphase-promoting complex 1 Q12834,O60566 61 1.73e-04 141 7 3 0.429 0.021 GO:0031398 BP 1 positive regulation of protein ubiquitination 1 Q12834,O43684,O60566 61 1.76e-04 113 7 3 0.429 0.027 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 Q12834,O43684,O60566 61 1.96e-04 147 7 3 0.429 0.020 GO:1903364 BP 1 positive regulation of cellular protein catabolic process 1 Q12834,O43684,O60566 61 2.08e-04 1745 7 6 0.857 0.003 GO:0009893 BP 1 positive regulation of metabolic process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 2.29e-04 155 7 3 0.429 0.019 GO:1903322 BP 1 positive regulation of protein modification by small protein conjugation or removal 1 Q12834,O43684,O60566 61 3.40e-04 177 7 3 0.429 0.017 GO:1903050 BP 1 regulation of proteolysis involved in cellular protein catabolic process 1 Q12834,O43684,O60566 61 3.88e-04 185 7 3 0.429 0.016 GO:0042787 BP 1 protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q12834,O43684,O60566 61 4.20e-04 190 7 3 0.429 0.016 GO:0031396 BP 1 regulation of protein ubiquitination 1 Q12834,O43684,O60566 61 4.26e-04 191 7 3 0.429 0.016 GO:0045732 BP 1 positive regulation of protein catabolic process 1 Q12834,O43684,O60566 61 4.26e-04 191 7 3 0.429 0.016 GO:1903362 BP 1 regulation of cellular protein catabolic process 1 Q12834,O43684,O60566 61 4.60e-04 196 7 3 0.429 0.015 GO:0000819 BP 1 sister chromatid segregation 1 Q12834,O43684,O60566 61 4.89e-04 200 7 3 0.429 0.015 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 Q12834,O43684,O60566 61 5.04e-04 161 7 3 0.429 0.019 REAC:2467813 rea 1 Separation of Sister Chromatids 1 Q12834,O43684,O60566 61 5.24e-04 4 7 2 0.286 0.500 HP:0006849 hp 1 Hypodysplasia of the corpus callosum 1 O43684,O60566 61 5.57e-04 209 7 3 0.429 0.014 GO:1903320 BP 1 regulation of protein modification by small protein conjugation or removal 1 Q12834,O43684,O60566 61 6.12e-04 172 7 3 0.429 0.017 REAC:68882 rea 1 Mitotic Anaphase 1 Q12834,O43684,O60566 61 6.23e-04 173 7 3 0.429 0.017 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 Q12834,O43684,O60566 61 6.29e-04 38 7 2 0.286 0.053 GO:0000152 CC 1 nuclear ubiquitin ligase complex 1 Q12834,O60566 61 6.33e-04 174 7 3 0.429 0.017 REAC:69620 rea 1 Cell Cycle Checkpoints 1 Q12834,O43684,O60566 61 7.01e-04 226 7 3 0.429 0.013 GO:0098813 BP 1 nuclear chromosome segregation 1 Q12834,O43684,O60566 61 7.48e-04 231 7 3 0.429 0.013 GO:0051348 BP 1 negative regulation of transferase activity 1 Q12834,O43684,O60566 61 7.77e-04 234 7 3 0.429 0.013 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 Q12834,O43684,O60566 61 8.07e-04 237 7 3 0.429 0.013 GO:0009896 BP 1 positive regulation of catabolic process 1 Q12834,O43684,O60566 61 8.69e-04 243 7 3 0.429 0.012 GO:1901987 BP 1 regulation of cell cycle phase transition 1 Q12834,O43684,O60566 61 8.72e-04 5 7 2 0.286 0.400 HP:0100650 hp 1 Vaginal neoplasm 1 O43684,O60566 61 1.01e-03 256 7 3 0.429 0.012 GO:0045862 BP 1 positive regulation of proteolysis 1 Q12834,O43684,O60566 61 1.10e-03 263 7 3 0.429 0.011 GO:0007059 BP 1 chromosome segregation 1 Q12834,O43684,O60566 61 1.15e-03 267 7 3 0.429 0.011 GO:0042176 BP 1 regulation of protein catabolic process 1 Q12834,O43684,O60566 61 1.21e-03 272 7 3 0.429 0.011 GO:0031329 BP 1 regulation of cellular catabolic process 1 Q12834,O43684,O60566 61 1.45e-03 231 7 3 0.429 0.013 REAC:195258 rea 1 RHO GTPase Effectors 1 Q12834,O43684,O60566 61 1.73e-03 307 7 3 0.429 0.010 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 Q12834,O43684,O60566 61 1.74e-03 1 7 1 0.143 1.000 GO:1990298 CC 1 bub1-bub3 complex 1 O43684 61 1.74e-03 1 7 1 0.143 1.000 GO:0033597 CC 1 mitotic checkpoint complex 1 O43684 61 1.74e-03 1 7 1 0.143 1.000 GO:0008124 MF 1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity 1 P61457 61 1.83e-03 7 7 2 0.286 0.286 HP:0200024 hp 1 Premature chromatid separation 1 O43684,O60566 61 1.89e-03 253 7 3 0.429 0.012 REAC:68886 rea 1 M Phase 1 Q12834,O43684,O60566 61 2.04e-03 325 7 3 0.429 0.009 GO:0010498 BP 1 proteasomal protein catabolic process 1 Q12834,O43684,O60566 61 2.53e-03 350 7 3 0.429 0.009 GO:0009894 BP 1 regulation of catabolic process 1 Q12834,O43684,O60566 61 2.82e-03 363 7 3 0.429 0.008 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q12834,O43684,O60566 61 2.98e-03 370 7 3 0.429 0.008 GO:0031400 BP 1 negative regulation of protein modification process 1 Q12834,O43684,O60566 61 2.98e-03 2761 7 6 0.857 0.002 GO:0048522 BP 1 positive regulation of cellular process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 3.47e-03 390 7 3 0.429 0.008 GO:0051347 BP 1 positive regulation of transferase activity 1 Q12834,O43684,O60566 61 3.47e-03 2 7 1 0.143 0.500 GO:0031915 BP 1 positive regulation of synaptic plasticity 1 Q12834 61 3.61e-03 91 7 2 0.286 0.022 GO:0000776 CC 1 kinetochore 1 O43684,O60566 61 3.79e-03 402 7 3 0.429 0.007 GO:0010564 BP 1 regulation of cell cycle process 1 Q12834,O43684,O60566 61 3.85e-03 404 7 3 0.429 0.007 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q12834,O43684,O60566 61 3.90e-03 10 7 2 0.286 0.200 HP:0200040 hp 1 Epidermoid cyst 1 O43684,O60566 61 3.96e-03 408 7 3 0.429 0.007 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q12834,O43684,O60566 61 4.04e-03 411 7 3 0.429 0.007 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q12834,O43684,O60566 61 4.19e-03 416 7 3 0.429 0.007 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q12834,O43684,O60566 61 4.21e-03 417 7 3 0.429 0.007 GO:0030162 BP 1 regulation of proteolysis 1 Q12834,O43684,O60566 61 4.27e-03 419 7 3 0.429 0.007 GO:0043086 BP 1 negative regulation of catalytic activity 1 Q12834,O43684,O60566 61 4.37e-03 338 7 3 0.429 0.009 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q12834,O43684,O60566 61 4.45e-03 425 7 3 0.429 0.007 GO:0044770 BP 1 cell cycle phase transition 1 Q12834,O43684,O60566 61 5.01e-03 3022 7 6 0.857 0.002 GO:0031323 BP 1 regulation of cellular metabolic process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 5.11e-03 3033 7 6 0.857 0.002 GO:0048518 BP 1 positive regulation of biological process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 5.12e-03 446 7 3 0.429 0.007 GO:0051276 BP 1 chromosome organization 1 Q12834,O43684,O60566 61 5.56e-03 459 7 3 0.429 0.007 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q12834,O43684,O60566 61 5.67e-03 462 7 3 0.429 0.006 GO:0016567 BP 1 protein ubiquitination 1 Q12834,O43684,O60566 61 6.34e-03 121 7 2 0.286 0.017 GO:0000775 CC 1 chromosome, centromeric region 1 O43684,O60566 61 6.48e-03 484 7 3 0.429 0.006 GO:0044257 BP 1 cellular protein catabolic process 1 Q12834,O43684,O60566 61 6.74e-03 13 7 2 0.286 0.154 HP:0002247 hp 1 Duodenal atresia 1 O43684,O60566 61 7.08e-03 128 7 2 0.286 0.016 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 O43684,O60566 61 7.47e-03 1141 7 4 0.571 0.004 GO:0044248 BP 1 cellular catabolic process 1 Q12834,O43684,O60566,P61457 61 7.75e-03 3263 7 6 0.857 0.002 GO:0019222 BP 1 regulation of metabolic process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 8.09e-03 137 7 2 0.286 0.015 GO:0031461 CC 1 cullin-RING ubiquitin ligase complex 1 Q12834,O60566 61 8.12e-03 117 7 3 0.429 0.026 KEGG:04110 keg 1 Cell cycle 1 Q12834,O43684,O60566 61 8.21e-03 6 7 1 0.143 0.167 REAC:176417 rea 1 Phosphorylation of Emi1 1 Q12834 61 8.67e-03 5 7 1 0.143 0.200 GO:0044342 BP 1 type B pancreatic cell proliferation 1 Q9BSF8 61 9.05e-03 15 7 2 0.286 0.133 HP:0001682 hp 1 Subaortic stenosis 1 O43684,O60566 61 9.05e-03 15 7 2 0.286 0.133 HP:0011103 hp 1 Abnormality of the left ventricular outflow tract 1 O43684,O60566 61 9.05e-03 15 7 2 0.286 0.133 HP:0011100 hp 1 Intestinal atresia 1 O43684,O60566 61 9.72e-03 448 7 3 0.429 0.007 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q12834,O43684,O60566 61 9.84e-03 560 7 3 0.429 0.005 GO:0030163 BP 1 protein catabolic process 1 Q12834,O43684,O60566 61 1.03e-02 16 7 2 0.286 0.125 HP:0002859 hp 1 Rhabdomyosarcoma 1 O43684,O60566 61 1.04e-02 570 7 3 0.429 0.005 GO:0044092 BP 1 negative regulation of molecular function 1 Q12834,O43684,O60566 61 1.05e-02 572 7 3 0.429 0.005 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 Q12834,O43684,O60566 61 1.05e-02 573 7 3 0.429 0.005 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q12834,O43684,O60566 61 1.07e-02 577 7 3 0.429 0.005 GO:0051338 BP 1 regulation of transferase activity 1 Q12834,O43684,O60566 61 1.17e-02 17 7 2 0.286 0.118 HP:0005387 hp 1 Combined immunodeficiency 1 O43684,O60566 61 1.18e-02 1290 7 4 0.571 0.003 GO:1901575 BP 1 organic substance catabolic process 1 Q12834,O43684,O60566,P61457 61 1.21e-02 7 7 1 0.143 0.143 GO:0090129 BP 1 positive regulation of synapse maturation 1 Q12834 61 1.21e-02 7 7 1 0.143 0.143 GO:0090128 BP 1 regulation of synapse maturation 1 Q12834 61 1.24e-02 170 7 2 0.286 0.012 GO:0045930 BP 1 negative regulation of mitotic cell cycle 1 O43684,O60566 61 1.24e-02 607 7 3 0.429 0.005 GO:0051248 BP 1 negative regulation of protein metabolic process 1 Q12834,O43684,O60566 61 1.27e-02 4019 7 6 0.857 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 1.29e-02 174 7 2 0.286 0.011 GO:0005819 CC 1 spindle 1 Q12834,O60566 61 1.31e-02 18 7 2 0.286 0.111 HP:0000879 hp 1 Short sternum 1 O43684,O60566 61 1.37e-02 10 7 1 0.143 0.100 REAC:71182 rea 1 Phenylalanine and tyrosine catabolism 1 P61457 61 1.43e-02 183 7 2 0.286 0.011 GO:0000075 BP 1 cell cycle checkpoint 1 O43684,O60566 61 1.44e-02 1362 7 4 0.571 0.003 GO:0009056 BP 1 catabolic process 1 Q12834,O43684,O60566,P61457 61 1.47e-02 19 7 2 0.286 0.105 HP:0002101 hp 1 Abnormal lung lobation 1 O43684,O60566 61 1.50e-02 650 7 3 0.429 0.005 GO:0031401 BP 1 positive regulation of protein modification process 1 Q12834,O43684,O60566 61 1.55e-02 657 7 3 0.429 0.005 GO:1903047 BP 1 mitotic cell cycle process 1 Q12834,O43684,O60566 61 1.56e-02 9 7 1 0.143 0.111 GO:0060074 BP 1 synapse maturation 1 Q12834 61 1.58e-02 662 7 3 0.429 0.005 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q12834,O43684,O60566 61 1.63e-02 20 7 2 0.286 0.100 HP:0010880 hp 1 Increased nuchal translucency 1 O43684,O60566 61 1.63e-02 20 7 2 0.286 0.100 HP:0000048 hp 1 Bifid scrotum 1 O43684,O60566 61 1.65e-02 671 7 3 0.429 0.004 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q12834,O43684,O60566 61 1.70e-02 547 7 3 0.429 0.005 REAC:1640170 rea 1 Cell Cycle 1 Q12834,O43684,O60566 61 1.70e-02 679 7 3 0.429 0.004 GO:0051726 BP 1 regulation of cell cycle 1 Q12834,O43684,O60566 61 1.73e-02 10 7 1 0.143 0.100 GO:0006558 BP 1 L-phenylalanine metabolic process 1 P61457 61 1.73e-02 10 7 1 0.143 0.100 GO:0006559 BP 1 L-phenylalanine catabolic process 1 P61457 61 1.73e-02 10 7 1 0.143 0.100 GO:1902221 BP 1 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 1 P61457 61 1.73e-02 10 7 1 0.143 0.100 GO:1902222 BP 1 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 1 P61457 61 1.80e-02 21 7 2 0.286 0.095 HP:0009728 hp 1 Neoplasm of striated muscle 1 O43684,O60566 61 2.01e-02 721 7 3 0.429 0.004 GO:0000278 BP 1 mitotic cell cycle 1 Q12834,O43684,O60566 61 2.06e-02 727 7 3 0.429 0.004 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q12834,O43684,O60566 61 2.08e-02 12 7 1 0.143 0.083 GO:0000940 CC 1 condensed chromosome outer kinetochore 1 O60566 61 2.10e-02 4407 7 6 0.857 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 2.15e-02 226 7 2 0.286 0.009 GO:0000151 CC 1 ubiquitin ligase complex 1 Q12834,O60566 61 2.16e-02 23 7 2 0.286 0.087 HP:0000207 hp 1 Triangular mouth 1 O43684,O60566 61 2.23e-02 230 7 2 0.286 0.009 GO:0098687 CC 1 chromosomal region 1 O43684,O60566 61 2.23e-02 1025 7 3 0.429 0.003 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q7Z5Y7,O43684,O60566 61 2.25e-02 13 7 1 0.143 0.077 GO:0034501 BP 1 protein localization to kinetochore 1 O60566 61 2.33e-02 4491 7 6 0.857 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 2.34e-02 236 7 2 0.286 0.008 GO:0007067 BP 1 mitotic nuclear division 1 O43684,O60566 61 2.35e-02 24 7 2 0.286 0.083 HP:0006872 hp 1 Cerebral hypoplasia 1 O43684,O60566 61 2.45e-02 18 7 1 0.143 0.056 REAC:176407 rea 1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1 Q12834 61 2.55e-02 25 7 2 0.286 0.080 HP:0001659 hp 1 Aortic regurgitation 1 O43684,O60566 61 2.59e-02 4578 7 6 0.857 0.001 HPA:003010_02 hpa 1 bone marrow; hematopoietic cells[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 2.77e-02 16 7 1 0.143 0.062 GO:0071459 BP 1 protein localization to chromosome, centromeric region 1 O60566 61 2.85e-02 3233 7 5 0.714 0.002 HPA:041010_02 hpa 1 spleen; cells in red pulp[Uncertain,Medium] 1 Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 2.86e-02 21 7 1 0.143 0.048 REAC:174048 rea 1 APC/C:Cdc20 mediated degradation of Cyclin B 1 Q12834 61 2.87e-02 1644 7 4 0.571 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q12834,Q9H0N5,O43684,O60566 61 2.94e-02 17 7 1 0.143 0.059 GO:0009074 BP 1 aromatic amino acid family catabolic process 1 P61457 61 2.96e-02 6530 7 7 1.000 0.001 HPA:015010_02 hpa 1 fallopian tube; glandular cells[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566,P61457 61 2.98e-02 27 7 2 0.286 0.074 HP:0006714 hp 1 Aplasia/Hypoplasia of the sternum 1 O43684,O60566 61 3.01e-02 832 7 3 0.429 0.004 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 Q12834,O43684,O60566 61 3.19e-02 850 7 3 0.429 0.004 GO:0044093 BP 1 positive regulation of molecular function 1 Q12834,O43684,O60566 61 3.44e-02 29 7 2 0.286 0.069 HP:0000445 hp 1 Wide nose 1 O43684,O60566 61 3.47e-02 876 7 3 0.429 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 Q12834,O43684,O60566 61 3.51e-02 880 7 3 0.429 0.003 GO:0051247 BP 1 positive regulation of protein metabolic process 1 Q12834,O43684,O60566 61 3.62e-02 4872 7 6 0.857 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566 61 3.63e-02 21 7 1 0.143 0.048 GO:0009072 BP 1 aromatic amino acid family metabolic process 1 P61457 61 3.67e-02 2837 7 6 0.857 0.002 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 Q7Z5Y7,Q9H0N5,Q9BSF8,O43684,O60566,P61457 61 3.67e-02 2837 7 6 0.857 0.002 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 Q7Z5Y7,Q9H0N5,Q9BSF8,O43684,O60566,P61457 61 3.68e-02 30 7 2 0.286 0.067 HP:0002916 hp 1 Abnormality of chromosome segregation 1 O43684,O60566 61 3.68e-02 30 7 2 0.286 0.067 HP:0100867 hp 1 Duodenal stenosis 1 O43684,O60566 61 3.68e-02 30 7 2 0.286 0.067 HP:0012848 hp 1 Small intestinal stenosis 1 O43684,O60566 61 3.68e-02 30 7 2 0.286 0.067 HP:0005266 hp 1 Intestinal polyp 1 O43684,O60566 61 3.68e-02 30 7 2 0.286 0.067 HP:0200008 hp 1 Intestinal polyposis 1 O43684,O60566 61 3.80e-02 22 7 1 0.143 0.045 GO:0051233 CC 1 spindle midzone 1 O60566 61 3.84e-02 1256 7 3 0.429 0.002 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 Q9BSF8,O43684,O60566 61 3.93e-02 309 7 2 0.286 0.006 GO:0000280 BP 1 nuclear division 1 O43684,O60566 61 3.97e-02 23 7 1 0.143 0.043 GO:0000777 CC 1 condensed chromosome kinetochore 1 O60566 61 3.97e-02 23 7 1 0.143 0.043 GO:0007094 BP 1 mitotic spindle assembly checkpoint 1 O43684 61 4.14e-02 6299 7 7 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566,P61457 61 4.14e-02 24 7 1 0.143 0.042 GO:0071173 BP 1 spindle assembly checkpoint 1 O43684 61 4.17e-02 937 7 3 0.429 0.003 GO:0006508 BP 1 proteolysis 1 Q12834,O43684,O60566 61 4.31e-02 25 7 1 0.143 0.040 GO:0071174 BP 1 mitotic spindle checkpoint 1 O43684 61 4.31e-02 25 7 1 0.143 0.040 GO:0045841 BP 1 negative regulation of mitotic metaphase/anaphase transition 1 O43684 61 4.31e-02 25 7 1 0.143 0.040 GO:2000816 BP 1 negative regulation of mitotic sister chromatid separation 1 O43684 61 4.36e-02 952 7 3 0.429 0.003 GO:0022402 BP 1 cell cycle process 1 Q12834,O43684,O60566 61 4.45e-02 33 7 2 0.286 0.061 HP:0002667 hp 1 Nephroblastoma 1 O43684,O60566 61 4.49e-02 26 7 1 0.143 0.038 GO:1902100 BP 1 negative regulation of metaphase/anaphase transition of cell cycle 1 O43684 61 4.55e-02 967 7 3 0.429 0.003 GO:0031399 BP 1 regulation of protein modification process 1 Q12834,O43684,O60566 61 4.66e-02 27 7 1 0.143 0.037 GO:0008608 BP 1 attachment of spindle microtubules to kinetochore 1 O43684 61 4.66e-02 27 7 1 0.143 0.037 GO:0033048 BP 1 negative regulation of mitotic sister chromatid segregation 1 O43684 61 4.72e-02 340 7 2 0.286 0.006 GO:0048285 BP 1 organelle fission 1 O43684,O60566 61 4.72e-02 34 7 2 0.286 0.059 HP:0011794 hp 1 Embryonal renal neoplasm 1 O43684,O60566 61 5.00e-02 35 7 2 0.286 0.057 HP:0002589 hp 1 Gastrointestinal atresia 1 O43684,O60566 61 5.00e-02 218 7 3 0.429 0.014 KEGG:05166 keg 1 HTLV-I infection 1 Q12834,O43684,O60566 61 5.00e-02 1 7 1 0.143 1.000 OMIM:257300 omi 1 MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 1; MVA1;;MVA SYNDROME 1 O60566 61 5.00e-02 2 7 1 0.143 0.500 CORUM:1851 cor 1 BUB1-BUB3 complex 1 O43684 61 5.00e-02 1 7 1 0.143 1.000 OMIM:264070 omi 1 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, D; HPABH4D;;HYPERPHENYLALANINEMIA, TETRAHYDROBIOPTERIN-DEFICIENT, DUE TO PTERIN-4-ALPHA-CARBINOLAMINEDEHYDRATASE DEFICIENCY;;HYPERPHENYLALANINEMIA WITH PRIMAPTERINURIA;;CADH DEFICIENCY;;PCBD DEFICIENCY 1 P61457 61 5.00e-02 37 7 1 0.143 0.027 REAC:6788656 rea 1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 1 P61457 61 5.00e-02 4707 7 7 1.000 0.001 TF:M04292_0 tf 1 Factor: BSX; motif: NYNATTAN; match class: 0 1 Q7Z5Y7,Q12834,Q9H0N5,Q9BSF8,O43684,O60566,P61457 61 5.00e-02 2 7 1 0.143 0.500 CORUM:2718 cor 1 MAD2-CDC20 complex 1 Q12834 61 5.00e-02 29 7 1 0.143 0.034 GO:0033046 BP 1 negative regulation of sister chromatid segregation 1 O43684 61 5.00e-02 1 7 1 0.143 1.000 OMIM:176430 omi 1 PREMATURE CHROMATID SEPARATION TRAIT; PCS;;TOTAL PREMATURE CHROMATID SEPARATION TRAIT 1 O60566 61 5.00e-02 386 7 3 0.429 0.008 MI:hsa-miR-624 mi 1 MI:hsa-miR-624 1 Q9H0N5,O43684,O60566 62 2.78e-13 15 6 5 0.833 0.333 REAC:446353 rea 1 Cell-extracellular matrix interactions 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 1.17e-11 7 6 4 0.667 0.571 REAC:446388 rea 1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 1 P49023,Q15404,P48059,Q9HBI1 62 2.39e-10 52 6 5 0.833 0.096 REAC:446728 rea 1 Cell junction organization 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 5.03e-09 94 6 5 0.833 0.053 REAC:1500931 rea 1 Cell-Cell communication 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 1.57e-06 333 6 5 0.833 0.015 GO:0005924 CC 1 cell-substrate adherens junction 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 1.57e-06 333 6 5 0.833 0.015 GO:0005925 CC 1 focal adhesion 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 1.66e-06 337 6 5 0.833 0.015 GO:0030055 CC 1 cell-substrate junction 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 4.36e-06 3 6 2 0.333 0.667 REAC:446343 rea 1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1 P49023,Q13418 62 9.40e-06 171 6 4 0.667 0.023 GO:0031589 BP 1 cell-substrate adhesion 1 Q9HBI0,Q15404,Q13418,P48059 62 2.54e-05 582 6 5 0.833 0.009 GO:0005912 CC 1 adherens junction 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 2.74e-05 591 6 5 0.833 0.008 GO:0070161 CC 1 anchoring junction 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 2.99e-05 3 6 2 0.333 0.667 CORUM:5498 cor 1 ILK-PARVB-ARHGEF6 complex 1 Q13418,Q9HBI1 62 5.43e-05 678 6 5 0.833 0.007 GO:0007155 BP 1 cell adhesion 1 P49023,Q9HBI0,Q15404,Q13418,P48059 62 5.67e-05 684 6 5 0.833 0.007 GO:0022610 BP 1 biological adhesion 1 P49023,Q9HBI0,Q15404,Q13418,P48059 62 8.72e-05 746 6 5 0.833 0.007 GO:0030054 CC 1 cell junction 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 2.46e-04 113 6 3 0.500 0.027 GO:0007160 BP 1 cell-matrix adhesion 1 Q9HBI0,Q13418,P48059 62 3.62e-04 179 6 4 0.667 0.022 KEGG:04510 keg 1 Focal adhesion 1 P49023,Q9HBI0,Q13418,Q9HBI1 62 1.77e-03 588 6 3 0.500 0.005 TF:M01252_1 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 1 1 P49023,Q15404,Q9HBI1 62 2.77e-03 43 6 2 0.333 0.047 GO:0010811 BP 1 positive regulation of cell-substrate adhesion 1 Q15404,P48059 62 4.24e-03 9 6 1 0.167 0.111 TF:M04205_0 tf 1 Factor: CREB3L1; motif: TGCCACGTGGCA; match class: 0 1 Q9HBI0 62 4.71e-03 10 6 1 0.167 0.100 TF:M06621_1 tf 1 Factor: ZNF479; motif: NSKACAAAMAGC; match class: 1 1 Q9HBI0 62 5.18e-03 11 6 1 0.167 0.091 TF:M06416_0 tf 1 Factor: ZNF429; motif: KGGAATTGGAKM; match class: 0 1 Q15404 62 5.24e-03 59 6 2 0.333 0.034 GO:0034446 BP 1 substrate adhesion-dependent cell spreading 1 Q13418,P48059 62 7.15e-03 1 6 1 0.167 1.000 GO:0071963 BP 1 establishment or maintenance of cell polarity regulating cell shape 1 Q9HBI1 62 8.46e-03 18 6 1 0.167 0.056 TF:M05832_0 tf 1 Factor: ZNF620; motif: NGCTKWAAACGM; match class: 0 1 Q15404 62 9.18e-03 2 6 1 0.167 0.500 CORUM:764 cor 1 Dysferlin-affixin complex 1 Q9HBI1 62 9.18e-03 2 6 1 0.167 0.500 CORUM:4025 cor 1 Affixin-actinin(alpha) complex 1 Q9HBI1 62 9.18e-03 2 6 1 0.167 0.500 CORUM:5499 cor 1 PARVB-ARHGEF6 complex 1 Q9HBI1 62 1.00e-02 341 6 2 0.333 0.006 TF:M06845_0 tf 1 Factor: ZBTB38; motif: NTYRATGCAMY; match class: 0 1 Q9HBI0,Q9HBI1 62 1.18e-02 371 6 2 0.333 0.005 TF:M06192_0 tf 1 Factor: ZNF135; motif: NTGTKGTSCAKA; match class: 0 1 Q13418,Q9HBI1 62 1.22e-02 90 6 2 0.333 0.022 GO:0010810 BP 1 regulation of cell-substrate adhesion 1 Q15404,P48059 62 1.22e-02 90 6 2 0.333 0.022 GO:0030027 CC 1 lamellipodium 1 P49023,Q9HBI1 62 1.22e-02 26 6 1 0.167 0.038 TF:M00984_1 tf 1 Factor: PEBP; motif: GNTNACCACARANNK; match class: 1 1 Q9HBI1 62 1.23e-02 2331 6 4 0.667 0.002 TF:M01223_0 tf 1 Factor: P50:P50; motif: NRGGGAMTNCCCN; match class: 0 1 P49023,Q9HBI0,Q13418,Q9HBI1 62 1.38e-02 3 6 1 0.167 0.333 CORUM:2726 cor 1 PXN-ITGB5-PTK2 complex 1 P49023 62 1.38e-02 3 6 1 0.167 0.333 CORUM:1810 cor 1 ITGA4-PXN-GIT1 complex 1 P49023 62 1.38e-02 3 6 1 0.167 0.333 CORUM:5318 cor 1 DDEF1-CTTN-PXN complex 1 P49023 62 1.52e-02 2472 6 4 0.667 0.002 TF:M03557_1 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 1 P49023,Q9HBI0,Q13418,Q9HBI1 62 1.68e-02 1301 6 3 0.500 0.002 TF:M02219_0 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 0 1 P49023,Q15404,Q9HBI1 62 1.73e-02 37 6 1 0.167 0.027 TF:M04511_0 tf 1 Factor: ZNF282; motif: CTTTCCCMYAACACGAN; match class: 0 1 P49023 62 1.74e-02 475 6 3 0.500 0.006 GO:0000902 BP 1 cell morphogenesis 1 Q13418,P48059,Q9HBI1 62 1.83e-02 4 6 1 0.167 0.250 CORUM:2363 cor 1 ITGAV-ITGB3-PXN-PTK2b complex 1 P49023 62 1.85e-02 111 6 2 0.333 0.018 GO:0043547 BP 1 positive regulation of GTPase activity 1 Q15404,P48059 62 1.87e-02 40 6 1 0.167 0.025 TF:M00068_1 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 1 1 Q13418 62 1.91e-02 4307 6 5 0.833 0.001 TF:M00172_0 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 0 1 P49023,Q9HBI0,Q15404,Q13418,Q9HBI1 62 1.96e-02 42 6 1 0.167 0.024 TF:M06218_0 tf 1 Factor: ZNF169; motif: NRGTYCAGRATA; match class: 0 1 Q9HBI0 62 2.20e-02 515 6 3 0.500 0.006 GO:0032989 BP 1 cellular component morphogenesis 1 Q13418,P48059,Q9HBI1 62 2.29e-02 49 6 1 0.167 0.020 TF:M05632_0 tf 1 Factor: ZNF286B; motif: NGYTTWGAAARA; match class: 0 1 P49023 62 2.32e-02 1464 6 3 0.500 0.002 TF:M00327_0 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 0 1 Q9HBI0,Q13418,Q9HBI1 62 2.39e-02 538 6 2 0.333 0.004 TF:M01595_1 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 1 1 Q15404,Q13418 62 2.41e-02 127 6 2 0.333 0.016 GO:0034329 BP 1 cell junction assembly 1 Q13418,P48059 62 2.45e-02 128 6 2 0.333 0.016 GO:0071560 BP 1 cellular response to transforming growth factor beta stimulus 1 P49023,P48059 62 2.49e-02 129 6 2 0.333 0.016 GO:0071559 BP 1 response to transforming growth factor beta 1 P49023,P48059 62 2.52e-02 54 6 1 0.167 0.019 TF:M04459_0 tf 1 Factor: ESRRB; motif: TCAAGGTCAWN; match class: 0 1 Q9HBI1 62 2.61e-02 56 6 1 0.167 0.018 TF:M03951_0 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 0 1 Q9HBI1 62 2.75e-02 59 6 1 0.167 0.017 TF:M04228_0 tf 1 Factor: XBP1; motif: WNNGMCACGTCATC; match class: 0 1 Q15404 62 3.16e-02 68 6 1 0.167 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q13418 62 3.18e-02 3035 6 4 0.667 0.001 TF:M02100_0 tf 1 Factor: MyoD; motif: CASCTGNCN; match class: 0 1 P49023,Q9HBI0,Q15404,Q9HBI1 62 3.22e-02 3045 6 4 0.667 0.001 TF:M07321_0 tf 1 Factor: HNF-4A; motif: NGNNCAAAGKYCAN; match class: 0 1 P49023,Q9HBI0,Q13418,Q9HBI1 62 3.35e-02 72 6 1 0.167 0.014 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 Q13418 62 3.39e-02 151 6 2 0.333 0.013 GO:0043087 BP 1 regulation of GTPase activity 1 Q15404,P48059 62 3.47e-02 657 6 2 0.333 0.003 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 P49023,Q9HBI0 62 3.58e-02 77 6 1 0.167 0.013 TF:M06650_0 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 0 1 Q9HBI0 62 3.62e-02 156 6 2 0.333 0.013 GO:0034330 BP 1 cell junction organization 1 Q13418,P48059 62 3.70e-02 1740 6 3 0.500 0.002 TF:M04412_1 tf 1 Factor: NKX2-8; motif: NCACTTSAN; match class: 1 1 P49023,Q15404,Q9HBI1 62 3.80e-02 82 6 1 0.167 0.012 TF:M03980_0 tf 1 Factor: ETV2; motif: AACCGGAAATR; match class: 0 1 Q15404 62 3.81e-02 3194 6 4 0.667 0.001 TF:M01031_0 tf 1 Factor: HNF-4; motif: NGGNCAAAGKYCAN; match class: 0 1 P49023,Q9HBI0,Q13418,Q9HBI1 62 3.94e-02 85 6 1 0.167 0.012 TF:M00634_1 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 1 1 Q9HBI1 62 4.19e-02 168 6 2 0.333 0.012 GO:0045785 BP 1 positive regulation of cell adhesion 1 Q15404,P48059 62 4.31e-02 93 6 1 0.167 0.011 TF:M00114_0 tf 1 Factor: Tax/CREB; motif: GGGGGTTGACGYANA; match class: 0 1 Q13418 62 4.34e-02 1848 6 3 0.500 0.002 TF:M00175_1 tf 1 Factor: AP-4; motif: VDCAGCTGNN; match class: 1 1 P49023,Q13418,Q9HBI1 62 4.40e-02 308 6 2 0.333 0.006 MI:hsa-miR-432* mi 1 MI:hsa-miR-432* 1 Q15404,Q13418 62 4.49e-02 97 6 1 0.167 0.010 TF:M00068_0 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 0 1 Q13418 62 4.49e-02 97 6 1 0.167 0.010 TF:M06106_0 tf 1 Factor: ZNF14; motif: KGGWCCATCAGT; match class: 0 1 P49023 62 4.51e-02 3354 6 4 0.667 0.001 TF:M01860_1 tf 1 Factor: AP-4; motif: NCAGCTGYNGNCN; match class: 1 1 P49023,Q9HBI0,Q15404,Q13418 62 4.53e-02 98 6 1 0.167 0.010 TF:M02219_1 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 1 Q9HBI1 62 4.59e-02 176 6 2 0.333 0.011 GO:0031252 CC 1 cell leading edge 1 P49023,Q9HBI1 62 4.71e-02 2707 6 5 0.833 0.002 GO:0005829 CC 1 cytosol 1 P49023,Q15404,Q13418,P48059,Q9HBI1 62 4.89e-02 1933 6 3 0.500 0.002 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 P49023,Q15404,Q9HBI1 62 4.90e-02 3435 6 4 0.667 0.001 TF:M00483_0 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 0 1 Q9HBI0,Q15404,Q13418,Q9HBI1 62 5.00e-02 73 6 2 0.333 0.027 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 P49023,Q13418 62 5.00e-02 24 6 1 0.167 0.042 REAC:8849471 rea 1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 P49023 62 5.00e-02 7 6 1 0.167 0.143 GO:0007172 BP 1 signal complex assembly 1 P49023 62 5.00e-02 11 6 1 0.167 0.091 CORUM:5177 cor 1 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 1 P49023 62 5.00e-02 24 6 1 0.167 0.042 REAC:445355 rea 1 Smooth Muscle Contraction 1 P49023 62 5.00e-02 329 6 2 0.333 0.006 MI:hsa-miR-363* mi 1 MI:hsa-miR-363* 1 Q13418,P48059 63 1.12e-03 20 4 2 0.500 0.100 CORUM:1332 cor 1 Large Drosha complex 1 P35637,Q01844 63 2.97e-03 1 4 1 0.250 1.000 OMIM:612219 omi 1 EWING SARCOMA; ESNEUROEPITHELIOMA, PERIPHERAL, INCLUDED; PNE, INCLUDED;;ASKIN TUMOR, INCLUDED 1 Q01844 63 2.97e-03 1 4 1 0.250 1.000 OMIM:614782 omi 1 TREMOR, HEREDITARY ESSENTIAL, 4; ETM4 1 P35637 63 2.97e-03 1 4 1 0.250 1.000 OMIM:608030 omi 1 AMYOTROPHIC LATERAL SCLEROSIS 6 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA;ALS6 1 P35637 63 3.38e-03 338 4 3 0.750 0.009 HPA:041010_13 hpa 1 spleen; cells in red pulp[Supportive,High] 1 Q13492,P35637,Q01844 63 3.58e-03 1 4 1 0.250 1.000 GO:1902961 BP 1 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 63 3.58e-03 1 4 1 0.250 1.000 GO:1905247 BP 1 positive regulation of aspartic-type peptidase activity 1 Q13492 63 3.72e-03 349 4 3 0.750 0.009 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 Q13492,P35637,Q01844 63 4.61e-03 375 4 3 0.750 0.008 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 Q13492,P35637,Q01844 63 5.55e-03 399 4 3 0.750 0.008 HPA:002020_13 hpa 1 appendix; lymphoid tissue[Supportive,High] 1 Q13492,P35637,Q01844 63 5.61e-03 41 4 2 0.500 0.049 HP:0100526 hp 1 Neoplasm of the lung 1 P35637,Q01844 63 5.93e-03 408 4 3 0.750 0.007 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q13492,P35637,Q01844 63 5.93e-03 2 4 1 0.250 0.500 OMIM:190300 omi 1 Essential Tremor 1 P35637 63 6.46e-03 44 4 2 0.500 0.045 HP:0100606 hp 1 Neoplasm of the respiratory system 1 P35637,Q01844 63 7.15e-03 2 4 1 0.250 0.500 GO:1902959 BP 1 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 63 7.15e-03 2 4 1 0.250 0.500 GO:1902962 BP 1 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 63 7.15e-03 2 4 1 0.250 0.500 GO:1905245 BP 1 regulation of aspartic-type peptidase activity 1 Q13492 63 7.15e-03 2 4 1 0.250 0.500 GO:1902963 BP 1 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 63 9.98e-03 486 4 3 0.750 0.006 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q13492,P35637,Q01844 63 1.25e-02 2 4 1 0.250 0.500 HP:0012268 hp 1 Myxoid liposarcoma 1 P35637 63 1.25e-02 2 4 1 0.250 0.500 HP:0012034 hp 1 Liposarcoma 1 P35637 63 1.37e-02 541 4 3 0.750 0.006 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 Q13492,P35637,Q01844 63 1.43e-02 4 4 1 0.250 0.250 GO:1902004 BP 1 positive regulation of beta-amyloid formation 1 Q13492 63 1.43e-02 4 4 1 0.250 0.250 GO:1902993 BP 1 positive regulation of amyloid precursor protein catabolic process 1 Q13492 63 1.43e-02 4 4 1 0.250 0.250 GO:0097459 BP 1 iron ion import into cell 1 Q13492 63 1.43e-02 4 4 1 0.250 0.250 GO:0032050 MF 1 clathrin heavy chain binding 1 Q13492 63 1.43e-02 4 4 1 0.250 0.250 GO:1904684 BP 1 negative regulation of metalloendopeptidase activity 1 Q13492 63 1.43e-02 4 4 1 0.250 0.250 GO:1905049 BP 1 negative regulation of metallopeptidase activity 1 Q13492 63 1.55e-02 564 4 3 0.750 0.005 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 1.72e-02 4 4 1 0.250 0.250 TF:M06760_0 tf 1 Factor: znf443; motif: KGTGCCCGTTGA; match class: 0 1 Q13492 63 1.77e-02 589 4 3 0.750 0.005 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 Q13492,P35637,Q01844 63 1.79e-02 5 4 1 0.250 0.200 GO:1905048 BP 1 regulation of metallopeptidase activity 1 Q13492 63 1.79e-02 5 4 1 0.250 0.200 GO:1904683 BP 1 regulation of metalloendopeptidase activity 1 Q13492 63 1.79e-02 5 4 1 0.250 0.200 GO:0097418 CC 1 neurofibrillary tangle 1 Q13492 63 1.79e-02 5 4 1 0.250 0.200 GO:0016188 BP 1 synaptic vesicle maturation 1 Q13492 63 1.83e-02 596 4 3 0.750 0.005 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 2.10e-02 625 4 3 0.750 0.005 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 2.12e-02 80 4 2 0.500 0.025 HP:0001428 hp 1 Somatic mutation 1 P35637,Q01844 63 2.15e-02 6 4 1 0.250 0.167 GO:0097286 BP 1 iron ion import 1 Q13492 63 2.15e-02 6 4 1 0.250 0.167 GO:1902992 BP 1 negative regulation of amyloid precursor protein catabolic process 1 Q13492 63 2.16e-02 5 4 1 0.250 0.200 TF:M05479_1 tf 1 Factor: znf580; motif: NGGGCGGTGTS; match class: 1 1 Q13492 63 2.40e-02 653 4 3 0.750 0.005 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 2.49e-02 4 4 1 0.250 0.250 HP:0012254 hp 1 Ewing's sarcoma 1 Q01844 63 2.50e-02 7 4 1 0.250 0.143 GO:0035459 BP 1 cargo loading into vesicle 1 Q13492 63 2.50e-02 7 4 1 0.250 0.143 GO:0048268 BP 1 clathrin coat assembly 1 Q13492 63 2.63e-02 674 4 3 0.750 0.004 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 Q13492,P35637,Q01844 63 2.67e-02 1890 4 4 1.000 0.002 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 Q13492,P35637,O60256,Q01844 63 2.74e-02 6 4 1 0.250 0.167 CORUM:1768 cor 1 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex 1 Q01844 63 2.86e-02 8 4 1 0.250 0.125 GO:0034205 BP 1 beta-amyloid formation 1 Q13492 63 2.86e-02 8 4 1 0.250 0.125 GO:1902003 BP 1 regulation of beta-amyloid formation 1 Q13492 63 3.11e-02 5 4 1 0.250 0.200 HP:0002501 hp 1 Spasticity of pharyngeal muscles 1 P35637 63 3.11e-02 5 4 1 0.250 0.200 HP:0002193 hp 1 Pseudobulbar behavioral symptoms 1 P35637 63 3.11e-02 5 4 1 0.250 0.200 HP:0002491 hp 1 Spasticity of facial muscles 1 P35637 63 3.13e-02 148 4 2 0.500 0.014 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 P35637,Q01844 63 3.22e-02 9 4 1 0.250 0.111 GO:0098748 MF 1 endocytic adaptor activity 1 Q13492 63 3.22e-02 9 4 1 0.250 0.111 GO:0035615 MF 1 clathrin adaptor activity 1 Q13492 63 3.54e-02 12 4 1 0.250 0.083 OMIM:600274 omi 1 Frontotemporal Lobar Degeneration 1 P35637 63 3.57e-02 10 4 1 0.250 0.100 GO:0030122 CC 1 AP-2 adaptor complex 1 Q13492 63 3.57e-02 10 4 1 0.250 0.100 GO:1902991 BP 1 regulation of amyloid precursor protein catabolic process 1 Q13492 63 3.57e-02 10 4 1 0.250 0.100 GO:0030128 CC 1 clathrin coat of endocytic vesicle 1 Q13492 63 3.68e-02 755 4 3 0.750 0.004 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q13492,P35637,Q01844 63 3.70e-02 161 4 2 0.500 0.012 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q13492,P35637 63 3.73e-02 6 4 1 0.250 0.167 HP:0002464 hp 1 Spastic dysarthria 1 P35637 63 3.73e-02 6 4 1 0.250 0.167 HP:0002425 hp 1 Anarthria 1 P35637 63 3.76e-02 761 4 3 0.750 0.004 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 3.90e-02 56 4 1 0.250 0.018 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 Q13492 63 3.93e-02 11 4 1 0.250 0.091 GO:0030132 CC 1 clathrin coat of coated pit 1 Q13492 63 3.93e-02 11 4 1 0.250 0.091 GO:0048261 BP 1 negative regulation of receptor-mediated endocytosis 1 Q13492 63 4.17e-02 113 4 2 0.500 0.018 HP:0002027 hp 1 Abdominal pain 1 P35637,Q01844 63 4.25e-02 294 4 2 0.500 0.007 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q13492,Q01844 63 4.26e-02 3006 4 4 1.000 0.001 TF:M03920_1 tf 1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 1 Q13492,P35637,O60256,Q01844 63 4.27e-02 794 4 3 0.750 0.004 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 Q13492,P35637,Q01844 63 4.33e-02 798 4 3 0.750 0.004 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 Q13492,P35637,Q01844 63 4.41e-02 803 4 3 0.750 0.004 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 Q13492,P35637,Q01844 63 4.43e-02 804 4 3 0.750 0.004 HPA:019010_03 hpa 1 kidney; cells in glomeruli[Uncertain,High] 1 Q13492,P35637,Q01844 63 4.44e-02 2146 4 4 1.000 0.002 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 Q13492,P35637,O60256,Q01844 63 4.64e-02 13 4 1 0.250 0.077 GO:0050435 BP 1 beta-amyloid metabolic process 1 Q13492 63 4.97e-02 8 4 1 0.250 0.125 HP:0000182 hp 1 Movement abnormality of the tongue 1 P35637 63 4.97e-02 8 4 1 0.250 0.125 HP:0003444 hp 1 EMG: chronic denervation signs 1 P35637 63 4.97e-02 8 4 1 0.250 0.125 HP:0000183 hp 1 Difficulty in tongue movements 1 P35637 63 5.00e-02 124 4 2 0.500 0.016 HP:0100242 hp 1 Sarcoma 1 P35637,Q01844 63 5.00e-02 14 4 1 0.250 0.071 GO:0030131 CC 1 clathrin adaptor complex 1 Q13492 63 5.00e-02 17 4 1 0.250 0.059 OMIM:601626 omi 1 LEUKEMIA, ACUTE MYELOID; AML;;LEUKEMIA, ACUTE MYELOGENOUSLEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO, INCLUDED 1 Q13492 63 5.00e-02 72 4 1 0.250 0.014 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 Q13492 63 5.00e-02 438 4 3 0.750 0.007 MI:hsa-miR-935 mi 1 MI:hsa-miR-935 1 P35637,O60256,Q01844 63 5.00e-02 838 4 3 0.750 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 Q13492,P35637,Q01844 63 5.00e-02 115 4 2 0.500 0.017 KEGG:05202 keg 1 Transcriptional misregulation in cancer 1 P35637,Q01844 63 5.00e-02 1267 4 3 0.750 0.002 TF:M07242_0 tf 1 Factor: AML1; motif: NNACCACAN; match class: 0 1 Q13492,P35637,Q01844 63 5.00e-02 72 4 1 0.250 0.014 REAC:421837 rea 1 Clathrin derived vesicle budding 1 Q13492 63 5.00e-02 11 4 1 0.250 0.091 CORUM:3082 cor 1 DGCR8 multiprotein complex 1 P35637 64 4.68e-05 7 7 2 0.286 0.286 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 O94842,Q96QC0 64 1.52e-04 330 7 4 0.571 0.012 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q9P270,O95359,O75410,Q14008 64 1.73e-04 13 7 2 0.286 0.154 GO:0035371 CC 1 microtubule plus-end 1 Q9P270,Q14008 64 1.96e-04 3 7 2 0.286 0.667 CORUM:631 cor 1 Tacc1-chTOG-AuroraA complex 1 O75410,Q14008 64 3.80e-04 19 7 2 0.286 0.105 GO:1990752 CC 1 microtubule end 1 Q9P270,Q14008 64 5.56e-04 459 7 4 0.571 0.009 GO:0007017 BP 1 microtubule-based process 1 Q9P270,O95359,O75410,Q14008 64 9.62e-04 30 7 2 0.286 0.067 GO:0021987 BP 1 cerebral cortex development 1 O95359,O75410 64 1.39e-03 36 7 2 0.286 0.056 GO:0008287 CC 1 protein serine/threonine phosphatase complex 1 O94842,Q96QC0 64 1.39e-03 36 7 2 0.286 0.056 GO:1903293 CC 1 phosphatase complex 1 O94842,Q96QC0 64 1.47e-03 37 7 2 0.286 0.054 GO:0021543 BP 1 pallium development 1 O95359,O75410 64 1.82e-03 230 7 3 0.429 0.013 GO:0098687 CC 1 chromosomal region 1 O94842,Q14008,Q96QC0 64 3.88e-03 60 7 2 0.286 0.033 GO:0021537 BP 1 telencephalon development 1 O95359,O75410 64 3.90e-03 758 7 4 0.571 0.005 GO:0007010 BP 1 cytoskeleton organization 1 Q9P270,O95359,O75410,Q14008 64 4.12e-03 769 7 4 0.571 0.005 GO:0015630 CC 1 microtubule cytoskeleton 1 Q9P270,O95359,O75410,Q14008 64 6.04e-03 11 7 1 0.143 0.091 TF:M05701_0 tf 1 Factor: ZNF30; motif: KGTGGKACCMGM; match class: 0 1 Q9P270 64 7.01e-03 674 7 3 0.429 0.004 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 O95359,Q14008,Q96QC0 64 8.14e-03 87 7 2 0.286 0.023 GO:0030900 BP 1 forebrain development 1 O95359,O75410 64 8.22e-03 15 7 1 0.143 0.067 TF:M05977_0 tf 1 Factor: ZNF257; motif: NTGTGCGGMSGA; match class: 0 1 Q14008 64 8.22e-03 15 7 1 0.143 0.067 TF:M06652_0 tf 1 Factor: ZNF696; motif: KGGTCMGAAAGM; match class: 0 1 Q9P270 64 1.07e-02 100 7 2 0.286 0.020 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 O94842,Q96QC0 64 1.15e-02 21 7 1 0.143 0.048 TF:M06250_0 tf 1 Factor: ZNF345; motif: NCGGGGTGYYGC; match class: 0 1 O75410 64 1.22e-02 272 7 2 0.286 0.007 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 O95359,Q14008 64 1.23e-02 972 7 3 0.429 0.003 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q9P270,O95359,Q8ND83 64 1.29e-02 3 7 1 0.143 0.333 GO:0030951 BP 1 establishment or maintenance of microtubule cytoskeleton polarity 1 Q14008 64 1.34e-02 112 7 2 0.286 0.018 GO:0000781 CC 1 chromosome, telomeric region 1 O94842,Q96QC0 64 1.37e-02 25 7 1 0.143 0.040 TF:M06240_0 tf 1 Factor: ZNF616; motif: NGGGTGGAACGM; match class: 0 1 Q9P270 64 1.42e-02 26 7 1 0.143 0.038 TF:M05364_0 tf 1 Factor: OZF; motif: NSGTCAAKAATC; match class: 0 1 O95359 64 1.44e-02 872 7 3 0.429 0.003 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 O95359,Q8ND83,Q14008 64 1.48e-02 27 7 1 0.143 0.037 TF:M06630_0 tf 1 Factor: ZNF2; motif: NGGGGAAGCCGA; match class: 0 1 Q9P270 64 1.52e-02 4895 7 6 0.857 0.001 TF:M07435_0 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 0 1 Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 1.54e-02 1960 7 5 0.714 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 O94842,Q9P270,O95359,Q14008,Q96QC0 64 1.54e-02 1960 7 5 0.714 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 O94842,Q9P270,O95359,Q14008,Q96QC0 64 1.81e-02 394 7 2 0.286 0.005 TF:M00953_0 tf 1 Factor: AR; motif: NNNGNRRGNACANNGTGTTCTNNNNNN; match class: 0 1 Q9P270,O75410 64 1.89e-02 965 7 3 0.429 0.003 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 O95359,Q14008,Q96QC0 64 1.95e-02 5123 7 6 0.857 0.001 TF:M03925_0 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 0 1 Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 1.96e-02 977 7 3 0.429 0.003 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 O95359,Q14008,Q96QC0 64 2.01e-02 1168 7 4 0.571 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q9P270,O95359,O75410,Q14008 64 2.04e-02 420 7 2 0.286 0.005 TF:M07270_1 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 1 O75410,Q96QC0 64 2.09e-02 1890 7 4 0.571 0.002 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 O95359,Q8ND83,Q14008,Q96QC0 64 2.10e-02 1182 7 3 0.429 0.003 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 O75410,Q14008,Q96QC0 64 2.13e-02 39 7 1 0.143 0.026 TF:M00707_1 tf 1 Factor: TFIIA; motif: TMTRWRAGGRSS; match class: 1 1 Q96QC0 64 2.21e-02 438 7 2 0.286 0.005 TF:M00956_0 tf 1 Factor: AR; motif: NNNNNNRGNACRNNGTGTTCTNNNNNN; match class: 0 1 Q9P270,O75410 64 2.23e-02 41 7 1 0.143 0.024 TF:M05512_0 tf 1 Factor: ZNF575; motif: NGGTGGGGGGGC; match class: 0 1 Q9P270 64 2.23e-02 41 7 1 0.143 0.024 TF:M06276_0 tf 1 Factor: ZNF642; motif: KGTAGYGAGATG; match class: 0 1 O75410 64 2.25e-02 3061 7 5 0.714 0.002 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 Q9P270,Q8ND83,O75410,Q14008,Q96QC0 64 2.25e-02 1204 7 4 0.571 0.003 GO:0005856 CC 1 cytoskeleton 1 Q9P270,O95359,O75410,Q14008 64 2.33e-02 4491 7 6 0.857 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 O94842,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 2.34e-02 451 7 2 0.286 0.004 TF:M06766_0 tf 1 Factor: ZNF835; motif: RCWAAGATW; match class: 0 1 Q8ND83,Q96QC0 64 2.49e-02 565 7 3 0.429 0.005 GO:0044427 CC 1 chromosomal part 1 O94842,Q14008,Q96QC0 64 2.57e-02 6 7 1 0.143 0.167 GO:0030952 BP 1 establishment or maintenance of cytoskeleton polarity 1 Q14008 64 2.64e-02 1091 7 3 0.429 0.003 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 O95359,Q14008,Q96QC0 64 2.66e-02 49 7 1 0.143 0.020 TF:M05632_0 tf 1 Factor: ZNF286B; motif: NGYTTWGAAARA; match class: 0 1 Q8ND83 64 2.77e-02 51 7 1 0.143 0.020 TF:M06391_0 tf 1 Factor: ZNF836; motif: NGGGGYTCCAGM; match class: 0 1 O95359 64 2.77e-02 51 7 1 0.143 0.020 TF:M06296_0 tf 1 Factor: ZNF568; motif: NTGGGKAAAAGA; match class: 0 1 Q8ND83 64 2.83e-02 52 7 1 0.143 0.019 TF:M07123_1 tf 1 Factor: rfx5; motif: YNSCMTRGCAACAGN; match class: 1 1 Q96QC0 64 2.91e-02 166 7 2 0.286 0.012 GO:0005874 CC 1 microtubule 1 Q9P270,Q14008 64 2.93e-02 54 7 1 0.143 0.019 TF:M04459_0 tf 1 Factor: ESRRB; motif: TCAAGGTCAWN; match class: 0 1 Q9P270 64 2.94e-02 1339 7 3 0.429 0.002 TF:M03925_1 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 1 Q8ND83,Q14008,Q96QC0 64 2.94e-02 510 7 2 0.286 0.004 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 O95359,Q8ND83 64 3.09e-02 609 7 3 0.429 0.005 GO:0005694 CC 1 chromosome 1 O94842,Q14008,Q96QC0 64 3.16e-02 530 7 2 0.286 0.004 TF:M07247_1 tf 1 Factor: CLOCK; motif: CCACSTGW; match class: 1 1 O95359,Q8ND83 64 3.17e-02 531 7 2 0.286 0.004 TF:M00447_0 tf 1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 0 1 Q9P270,O75410 64 3.21e-02 6607 7 7 1.000 0.001 HPA:002010_02 hpa 1 appendix; glandular cells[Uncertain,Medium] 1 O94842,Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 3.25e-02 456 7 2 0.286 0.004 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 O95359,Q14008 64 3.31e-02 61 7 1 0.143 0.016 TF:M06332_0 tf 1 Factor: ZNF585A; motif: CACCTGGCTAAC; match class: 0 1 Q14008 64 3.39e-02 53 7 1 0.143 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q14008 64 3.42e-02 2565 7 4 0.571 0.002 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 Q9P270,O95359,Q8ND83,O75410 64 3.61e-02 6719 7 7 1.000 0.001 HPA:024010_02 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,Medium] 1 O94842,Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 3.68e-02 68 7 1 0.143 0.015 TF:M07223_1 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 1 1 O75410 64 3.73e-02 69 7 1 0.143 0.014 TF:M01132_1 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 1 1 Q9P270 64 3.73e-02 69 7 1 0.143 0.014 TF:M07253_1 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 1 1 Q9P270 64 3.76e-02 1247 7 3 0.429 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 O95359,Q14008,Q96QC0 64 3.92e-02 505 7 2 0.286 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q14008,Q96QC0 64 4.09e-02 5877 7 6 0.857 0.001 TF:M04437_0 tf 1 Factor: RHOXF1; motif: NTRATCCN; match class: 0 1 Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 4.32e-02 80 7 1 0.143 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 Q8ND83 64 4.33e-02 628 7 2 0.286 0.003 TF:M04611_1 tf 1 Factor: FOXM1; motif: NAGASTGATTA; match class: 1 1 Q8ND83,Q96QC0 64 4.40e-02 634 7 2 0.286 0.003 TF:M03939_0 tf 1 Factor: ZNF740; motif: CCCCCCCCAC; match class: 0 1 Q8ND83,Q96QC0 64 4.48e-02 83 7 1 0.143 0.012 TF:M04473_0 tf 1 Factor: NR2F1; motif: RRGGTCAARAGGTCAN; match class: 0 1 Q96QC0 64 4.61e-02 210 7 2 0.286 0.010 GO:0007420 BP 1 brain development 1 O95359,O75410 64 4.61e-02 4263 7 5 0.714 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 Q9P270,O95359,Q8ND83,O75410,Q14008 64 4.66e-02 555 7 2 0.286 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 O95359,Q14008 64 4.69e-02 87 7 1 0.143 0.011 TF:M05412_0 tf 1 Factor: ZNF579; motif: NGYGGGGWGGGG; match class: 0 1 O75410 64 4.70e-02 11 7 1 0.143 0.091 GO:0031116 BP 1 positive regulation of microtubule polymerization 1 Q9P270 64 4.81e-02 6057 7 6 0.857 0.001 TF:M00412_0 tf 1 Factor: AREB6; motif: NNYNYACCTGWVT; match class: 0 1 Q9P270,O95359,Q8ND83,O75410,Q14008,Q96QC0 64 4.90e-02 1380 7 3 0.429 0.002 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 O95359,Q8ND83,Q14008 64 5.00e-02 2 7 1 0.143 0.500 CORUM:180 cor 1 PNUTS-PP1 complex 1 Q96QC0 64 5.00e-02 219 7 2 0.286 0.009 GO:0060322 BP 1 head development 1 O95359,O75410 64 5.00e-02 560 7 4 0.571 0.007 MI:hsa-miR-19a mi 1 MI:hsa-miR-19a 1 O95359,Q8ND83,Q14008,Q96QC0 65 1.01e-03 101 3 2 0.667 0.020 GO:0007088 BP 1 regulation of mitotic nuclear division 1 Q15013,Q13257 65 1.13e-03 107 3 2 0.667 0.019 GO:0051783 BP 1 regulation of nuclear division 1 Q15013,Q13257 65 1.62e-03 128 3 2 0.667 0.016 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 Q15013,Q13257 65 2.86e-03 170 3 2 0.667 0.012 GO:0045930 BP 1 negative regulation of mitotic cell cycle 1 Q15013,Q13257 65 3.31e-03 183 3 2 0.667 0.011 GO:0000075 BP 1 cell cycle checkpoint 1 Q15013,Q13257 65 3.48e-03 3 3 1 0.333 0.333 GO:2000467 BP 1 positive regulation of glycogen (starch) synthase activity 1 Q7L775 65 5.01e-03 2 3 1 0.333 0.500 REAC:141444 rea 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1 Q13257 65 5.01e-03 2 3 1 0.333 0.500 REAC:141424 rea 1 Amplification of signal from the kinetochores 1 Q13257 65 5.41e-03 234 3 2 0.667 0.009 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 Q15013,Q13257 65 5.50e-03 236 3 2 0.667 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q15013,Q13257 65 5.83e-03 243 3 2 0.667 0.008 GO:1901987 BP 1 regulation of cell cycle phase transition 1 Q15013,Q13257 65 6.95e-03 6 3 1 0.333 0.167 GO:2000465 BP 1 regulation of glycogen (starch) synthase activity 1 Q7L775 65 8.11e-03 7 3 1 0.333 0.143 GO:0090267 BP 1 positive regulation of mitotic cell cycle spindle assembly checkpoint 1 Q13257 65 9.27e-03 8 3 1 0.333 0.125 GO:0090232 BP 1 positive regulation of spindle checkpoint 1 Q13257 65 9.27e-03 8 3 1 0.333 0.125 GO:0045725 BP 1 positive regulation of glycogen biosynthetic process 1 Q7L775 65 9.39e-03 309 3 2 0.667 0.006 GO:0000280 BP 1 nuclear division 1 Q15013,Q13257 65 1.04e-02 9 3 1 0.333 0.111 GO:1901978 BP 1 positive regulation of cell cycle checkpoint 1 Q13257 65 1.04e-02 9 3 1 0.333 0.111 GO:0070875 BP 1 positive regulation of glycogen metabolic process 1 Q7L775 65 1.14e-02 340 3 2 0.667 0.006 GO:0048285 BP 1 organelle fission 1 Q15013,Q13257 65 1.27e-02 11 3 1 0.333 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q13257 65 1.27e-02 11 3 1 0.333 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q13257 65 1.29e-02 363 3 2 0.667 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q15013,Q13257 65 1.39e-02 376 3 2 0.667 0.005 GO:0045786 BP 1 negative regulation of cell cycle 1 Q15013,Q13257 65 1.39e-02 12 3 1 0.333 0.083 GO:0010907 BP 1 positive regulation of glucose metabolic process 1 Q7L775 65 1.49e-02 390 3 2 0.667 0.005 GO:0051347 BP 1 positive regulation of transferase activity 1 Q13257,Q7L775 65 1.51e-02 13 3 1 0.333 0.077 GO:0007096 BP 1 regulation of exit from mitosis 1 Q15013 65 1.58e-02 402 3 2 0.667 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 Q15013,Q13257 65 1.62e-02 14 3 1 0.333 0.071 GO:0090231 BP 1 regulation of spindle checkpoint 1 Q13257 65 1.65e-02 411 3 2 0.667 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q15013,Q13257 65 1.74e-02 15 3 1 0.333 0.067 GO:0010962 BP 1 regulation of glucan biosynthetic process 1 Q7L775 65 1.74e-02 15 3 1 0.333 0.067 GO:0005979 BP 1 regulation of glycogen biosynthetic process 1 Q7L775 65 1.77e-02 425 3 2 0.667 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q15013,Q13257 65 1.97e-02 17 3 1 0.333 0.059 GO:0070873 BP 1 regulation of glycogen metabolic process 1 Q7L775 65 2.31e-02 20 3 1 0.333 0.050 GO:0032885 BP 1 regulation of polysaccharide biosynthetic process 1 Q7L775 65 2.43e-02 21 3 1 0.333 0.048 GO:0010676 BP 1 positive regulation of cellular carbohydrate metabolic process 1 Q7L775 65 2.50e-02 2 3 1 0.333 0.500 CORUM:1814 cor 1 MAD1L1-MAD2L1 complex 1 Q13257 65 2.50e-02 2 3 1 0.333 0.500 CORUM:2718 cor 1 MAD2-CDC20 complex 1 Q13257 65 2.55e-02 22 3 1 0.333 0.045 GO:0032881 BP 1 regulation of polysaccharide metabolic process 1 Q7L775 65 2.66e-02 23 3 1 0.333 0.043 GO:0007094 BP 1 mitotic spindle assembly checkpoint 1 Q13257 65 2.78e-02 24 3 1 0.333 0.042 GO:0010458 BP 1 exit from mitosis 1 Q15013 65 2.78e-02 24 3 1 0.333 0.042 GO:0071173 BP 1 spindle assembly checkpoint 1 Q13257 65 2.89e-02 25 3 1 0.333 0.040 GO:1901976 BP 1 regulation of cell cycle checkpoint 1 Q13257 65 2.89e-02 25 3 1 0.333 0.040 GO:0071174 BP 1 mitotic spindle checkpoint 1 Q13257 65 2.89e-02 25 3 1 0.333 0.040 GO:2000816 BP 1 negative regulation of mitotic sister chromatid separation 1 Q13257 65 2.89e-02 25 3 1 0.333 0.040 GO:0045841 BP 1 negative regulation of mitotic metaphase/anaphase transition 1 Q13257 65 3.01e-02 26 3 1 0.333 0.038 GO:1902100 BP 1 negative regulation of metaphase/anaphase transition of cell cycle 1 Q13257 65 3.12e-02 27 3 1 0.333 0.037 GO:0033048 BP 1 negative regulation of mitotic sister chromatid segregation 1 Q13257 65 3.23e-02 577 3 2 0.667 0.003 GO:0051338 BP 1 regulation of transferase activity 1 Q13257,Q7L775 65 3.35e-02 29 3 1 0.333 0.034 GO:0033046 BP 1 negative regulation of sister chromatid segregation 1 Q13257 65 3.47e-02 30 3 1 0.333 0.033 GO:0031577 BP 1 spindle checkpoint 1 Q13257 65 3.47e-02 30 3 1 0.333 0.033 GO:0045913 BP 1 positive regulation of carbohydrate metabolic process 1 Q7L775 65 3.47e-02 30 3 1 0.333 0.033 GO:0051985 BP 1 negative regulation of chromosome segregation 1 Q13257 65 3.56e-02 420 3 2 0.667 0.005 MI:hsa-miR-651 mi 1 MI:hsa-miR-651 1 Q15013,Q13257 65 3.58e-02 31 3 1 0.333 0.032 GO:0009250 BP 1 glucan biosynthetic process 1 Q7L775 65 3.58e-02 31 3 1 0.333 0.032 GO:0005978 BP 1 glycogen biosynthetic process 1 Q7L775 65 3.81e-02 33 3 1 0.333 0.030 GO:0045839 BP 1 negative regulation of mitotic nuclear division 1 Q13257 65 3.87e-02 438 3 2 0.667 0.005 MI:hsa-miR-935 mi 1 MI:hsa-miR-935 1 Q15013,Q13257 65 4.04e-02 35 3 1 0.333 0.029 GO:0030071 BP 1 regulation of mitotic metaphase/anaphase transition 1 Q13257 65 4.16e-02 36 3 1 0.333 0.028 GO:1902099 BP 1 regulation of metaphase/anaphase transition of cell cycle 1 Q13257 65 4.17e-02 657 3 2 0.667 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q15013,Q13257 65 4.28e-02 37 3 1 0.333 0.027 GO:0010965 BP 1 regulation of mitotic sister chromatid separation 1 Q13257 65 4.28e-02 37 3 1 0.333 0.027 GO:0007091 BP 1 metaphase/anaphase transition of mitotic cell cycle 1 Q13257 65 4.28e-02 37 3 1 0.333 0.027 GO:0051784 BP 1 negative regulation of nuclear division 1 Q13257 65 4.34e-02 671 3 2 0.667 0.003 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q13257,Q7L775 65 4.39e-02 38 3 1 0.333 0.026 GO:0044784 BP 1 metaphase/anaphase transition of cell cycle 1 Q13257 65 4.39e-02 38 3 1 0.333 0.026 GO:0051306 BP 1 mitotic sister chromatid separation 1 Q13257 65 4.45e-02 679 3 2 0.667 0.003 GO:0051726 BP 1 regulation of cell cycle 1 Q15013,Q13257 65 4.55e-02 78 3 1 0.333 0.013 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 Q13257 65 4.62e-02 40 3 1 0.333 0.025 GO:0043255 BP 1 regulation of carbohydrate biosynthetic process 1 Q7L775 65 4.75e-02 19 3 1 0.333 0.053 REAC:141405 rea 1 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 1 Q13257 65 4.75e-02 19 3 1 0.333 0.053 REAC:141430 rea 1 Inactivation of APC/C via direct inhibition of the APC/C complex 1 Q13257 65 4.81e-02 707 3 2 0.667 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q15013,Q13257 65 4.85e-02 42 3 1 0.333 0.024 GO:0033692 BP 1 cellular polysaccharide biosynthetic process 1 Q7L775 65 4.97e-02 43 3 1 0.333 0.023 GO:0072686 CC 1 mitotic spindle 1 Q13257 65 5.00e-02 721 3 2 0.667 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q15013,Q13257 65 5.00e-02 20 3 1 0.333 0.050 REAC:69618 rea 1 Mitotic Spindle Checkpoint 1 Q13257 65 5.00e-02 6 3 1 0.333 0.167 TF:M03959_1 tf 1 Factor: E2F2; motif: NNTTTTGGCGCCAAAAWN; match class: 1 1 Q7L775 65 5.00e-02 499 3 2 0.667 0.004 MI:hsa-miR-582-5p mi 1 MI:hsa-miR-582-5p 1 Q15013,Q13257 65 5.00e-02 4 3 1 0.333 0.250 CORUM:190 cor 1 Mitotic checkpoint complex (MCC) 1 Q13257 65 5.00e-02 6 3 1 0.333 0.167 TF:M03962_1 tf 1 Factor: E2F3; motif: NNTTTTGGCGCCAAAACT; match class: 1 1 Q7L775 66 8.71e-05 3 5 2 0.400 0.667 CORUM:631 cor 1 Tacc1-chTOG-AuroraA complex 1 O75410,Q14008 66 5.79e-04 30 5 2 0.400 0.067 GO:0021987 BP 1 cerebral cortex development 1 O95359,O75410 66 8.85e-04 37 5 2 0.400 0.054 GO:0021543 BP 1 pallium development 1 O95359,O75410 66 1.98e-03 330 5 3 0.600 0.009 GO:0000226 BP 1 microtubule cytoskeleton organization 1 O95359,O75410,Q14008 66 2.34e-03 60 5 2 0.400 0.033 GO:0021537 BP 1 telencephalon development 1 O95359,O75410 66 4.64e-03 872 5 3 0.600 0.003 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 O95359,Q8ND83,Q14008 66 4.93e-03 87 5 2 0.400 0.023 GO:0030900 BP 1 forebrain development 1 O95359,O75410 66 5.24e-03 459 5 3 0.600 0.007 GO:0007017 BP 1 microtubule-based process 1 O95359,O75410,Q14008 66 5.88e-03 15 5 1 0.200 0.067 TF:M05977_0 tf 1 Factor: ZNF257; motif: NTGTGCGGMSGA; match class: 0 1 Q14008 66 6.02e-03 272 5 2 0.400 0.007 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 O95359,Q14008 66 8.22e-03 21 5 1 0.200 0.048 TF:M06250_0 tf 1 Factor: ZNF345; motif: NCGGGGTGYYGC; match class: 0 1 O75410 66 1.02e-02 26 5 1 0.200 0.038 TF:M05364_0 tf 1 Factor: OZF; motif: NSGTCAAKAATC; match class: 0 1 O95359 66 1.06e-02 2875 5 4 0.800 0.001 TF:M03788_0 tf 1 Factor: CAR_RXR; motif: CYNNNNTGAMCTYW; match class: 0 1 O95359,Q8ND83,O75410,Q14008 66 1.16e-02 3 5 1 0.200 0.333 GO:0030951 BP 1 establishment or maintenance of microtubule cytoskeleton polarity 1 Q14008 66 1.24e-02 4491 5 5 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 1.32e-02 2582 5 4 0.800 0.002 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 O95359,Q8ND83,O75410,Q14008 66 1.48e-02 510 5 2 0.400 0.004 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 O95359,Q8ND83 66 1.59e-02 530 5 2 0.400 0.004 TF:M07247_1 tf 1 Factor: CLOCK; motif: CCACSTGW; match class: 1 1 O95359,Q8ND83 66 1.60e-02 41 5 1 0.200 0.024 TF:M06276_0 tf 1 Factor: ZNF642; motif: KGTAGYGAGATG; match class: 0 1 O75410 66 1.64e-02 456 5 2 0.400 0.004 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 O95359,Q14008 66 1.71e-02 1380 5 3 0.600 0.002 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 O95359,Q8ND83,Q14008 66 1.91e-02 49 5 1 0.200 0.020 TF:M05632_0 tf 1 Factor: ZNF286B; motif: NGYTTWGAAARA; match class: 0 1 Q8ND83 66 1.99e-02 51 5 1 0.200 0.020 TF:M06296_0 tf 1 Factor: ZNF568; motif: NTGGGKAAAAGA; match class: 0 1 Q8ND83 66 1.99e-02 51 5 1 0.200 0.020 TF:M06391_0 tf 1 Factor: ZNF836; motif: NGGGGYTCCAGM; match class: 0 1 O95359 66 2.10e-02 1488 5 3 0.600 0.002 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 Q8ND83,O75410,Q14008 66 2.27e-02 758 5 3 0.600 0.004 GO:0007010 BP 1 cytoskeleton organization 1 O95359,O75410,Q14008 66 2.31e-02 6 5 1 0.200 0.167 GO:0030952 BP 1 establishment or maintenance of cytoskeleton polarity 1 Q14008 66 2.37e-02 769 5 3 0.600 0.004 GO:0015630 CC 1 microtubule cytoskeleton 1 O95359,O75410,Q14008 66 2.37e-02 61 5 1 0.200 0.016 TF:M06332_0 tf 1 Factor: ZNF585A; motif: CACCTGGCTAAC; match class: 0 1 Q14008 66 2.38e-02 555 5 2 0.400 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 O95359,Q14008 66 2.43e-02 53 5 1 0.200 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q14008 66 2.64e-02 68 5 1 0.200 0.015 TF:M07223_1 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 1 1 O75410 66 2.70e-02 7 5 1 0.200 0.143 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 O94842 66 2.73e-02 1635 5 3 0.600 0.002 HPA:039020_02 hpa 1 soft tissue 1; chondrocytes[Uncertain,Medium] 1 O95359,Q8ND83,Q14008 66 2.83e-02 210 5 2 0.400 0.010 GO:0007420 BP 1 brain development 1 O95359,O75410 66 3.07e-02 219 5 2 0.400 0.009 GO:0060322 BP 1 head development 1 O95359,O75410 66 3.10e-02 80 5 1 0.200 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 Q8ND83 66 3.33e-02 5469 5 5 1.000 0.001 HPA:007020_01 hpa 1 cerebral cortex; glial cells[Uncertain,Low] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 3.37e-02 87 5 1 0.200 0.011 TF:M05412_0 tf 1 Factor: ZNF579; motif: NGYGGGGWGGGG; match class: 0 1 O75410 66 3.38e-02 230 5 2 0.400 0.009 GO:0098687 CC 1 chromosomal region 1 O94842,Q14008 66 3.40e-02 3924 5 4 0.800 0.001 TF:M04318_0 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 0 1 O95359,Q8ND83,O75410,Q14008 66 3.43e-02 674 5 2 0.400 0.003 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 O95359,Q14008 66 3.45e-02 2101 5 3 0.600 0.001 TF:M03793_0 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 0 1 O95359,Q8ND83,O75410 66 3.60e-02 93 5 1 0.200 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 O95359 66 3.64e-02 3999 5 4 0.800 0.001 TF:M07255_1 tf 1 Factor: Foxm1; motif: NTGTTTRT; match class: 1 1 O95359,Q8ND83,O75410,Q14008 66 3.76e-02 1838 5 3 0.600 0.002 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 O95359,Q8ND83,Q14008 66 3.79e-02 98 5 1 0.200 0.010 TF:M07050_1 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 1 1 O95359 66 3.79e-02 98 5 1 0.200 0.010 TF:M02219_1 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 1 O75410 66 3.86e-02 5632 5 5 1.000 0.001 HPA:004020_02 hpa 1 breast; glandular cells[Uncertain,Medium] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 3.88e-02 5636 5 5 1.000 0.001 HPA:014010_02 hpa 1 esophagus; squamous epithelial cells[Uncertain,Medium] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 4.05e-02 1890 5 3 0.600 0.002 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 O95359,Q8ND83,Q14008 66 4.06e-02 105 5 1 0.200 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 O75410 66 4.13e-02 107 5 1 0.200 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 Q8ND83 66 4.21e-02 109 5 1 0.200 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q8ND83 66 4.29e-02 5752 5 5 1.000 0.001 HPA:022020_01 hpa 1 lung; pneumocytes[Uncertain,Low] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 4.33e-02 900 5 2 0.400 0.002 TF:M03565_1 tf 1 Factor: slug; motif: KCACCTGN; match class: 1 1 O95359,Q8ND83 66 4.40e-02 5782 5 5 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 4.44e-02 2305 5 3 0.600 0.001 TF:M00289_1 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 1 O95359,O75410,Q14008 66 4.49e-02 66 5 1 0.200 0.015 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 Q14008 66 4.49e-02 66 5 1 0.200 0.015 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 Q14008 66 4.49e-02 4233 5 4 0.800 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 O95359,Q8ND83,O75410,Q14008 66 4.52e-02 922 5 2 0.400 0.002 TF:M04231_0 tf 1 Factor: FOXB1; motif: TGTAAAYAN; match class: 0 1 O95359,Q8ND83 66 4.55e-02 5819 5 5 1.000 0.001 HPA:033010_02 hpa 1 seminal vesicle; glandular cells[Uncertain,Medium] 1 O94842,O95359,Q8ND83,O75410,Q14008 66 4.60e-02 4263 5 4 0.800 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 O95359,Q8ND83,O75410,Q14008 66 4.68e-02 939 5 2 0.400 0.002 TF:M03843_1 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 1 1 Q8ND83,Q14008 66 4.69e-02 69 5 1 0.200 0.014 REAC:8854518 rea 1 AURKA Activation by TPX2 1 Q14008 66 4.85e-02 126 5 1 0.200 0.008 TF:M00478_1 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 1 1 Q14008 66 4.99e-02 972 5 2 0.400 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 O95359,Q8ND83 66 5.00e-02 13 5 1 0.200 0.077 GO:0035371 CC 1 microtubule plus-end 1 Q14008 66 5.00e-02 3 5 1 0.200 0.333 CORUM:5373 cor 1 Chromatin remodeling complex (TACC2, TACC3, PCAF) 1 O95359 66 5.00e-02 560 5 3 0.600 0.005 MI:hsa-miR-19a mi 1 MI:hsa-miR-19a 1 O95359,Q8ND83,Q14008 67 3.51e-03 2 4 1 0.250 0.500 CORUM:180 cor 1 PNUTS-PP1 complex 1 P62136 67 3.97e-03 1107 4 3 0.750 0.003 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 7.00e-03 392 4 2 0.500 0.005 MI:hsa-miR-551a mi 1 MI:hsa-miR-551a 1 Q9GZN8,P62136 67 7.00e-03 392 4 2 0.500 0.005 MI:hsa-miR-551b mi 1 MI:hsa-miR-551b 1 Q9GZN8,P62136 67 7.23e-03 1360 4 3 0.750 0.002 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 7.78e-03 399 4 2 0.500 0.005 HPA:002020_13 hpa 1 appendix; lymphoid tissue[Supportive,High] 1 Q12972,Q8NI77 67 7.97e-03 404 4 2 0.500 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q12972,Q8NI77 67 7.99e-03 1408 4 3 0.750 0.002 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 8.50e-03 433 4 2 0.500 0.005 MI:hsa-miR-552 mi 1 MI:hsa-miR-552 1 Q12972,P62136 67 9.00e-03 446 4 2 0.500 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q9GZN8,P62136 67 9.56e-03 460 4 2 0.500 0.004 MI:hsa-miR-26b mi 1 MI:hsa-miR-26b 1 Q9GZN8,Q8NI77 67 9.60e-03 461 4 2 0.500 0.004 MI:hsa-miR-589 mi 1 MI:hsa-miR-589 1 Q8NI77,P62136 67 9.93e-03 469 4 2 0.500 0.004 MI:hsa-miR-26a mi 1 MI:hsa-miR-26a 1 Q9GZN8,Q8NI77 67 1.07e-02 1559 4 3 0.750 0.002 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.10e-02 1574 4 3 0.750 0.002 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.13e-02 1589 4 3 0.750 0.002 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.20e-02 1621 4 3 0.750 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 1.28e-02 1659 4 3 0.750 0.002 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.39e-02 537 4 2 0.500 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q12972,Q8NI77 67 1.48e-02 555 4 2 0.500 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 Q12972,Q8NI77 67 1.52e-02 564 4 2 0.500 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q12972,Q8NI77 67 1.53e-02 1765 4 3 0.750 0.002 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 1.54e-02 1769 4 3 0.750 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.57e-02 9 4 1 0.250 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P62136 67 1.65e-02 1813 4 3 0.750 0.002 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 1.69e-02 1825 4 3 0.750 0.002 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 1.83e-02 1880 4 3 0.750 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.04e-02 1950 4 3 0.750 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.05e-02 658 4 2 0.500 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 Q12972,Q8NI77 67 2.14e-02 1986 4 3 0.750 0.002 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.15e-02 1989 4 3 0.750 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.18e-02 1996 4 3 0.750 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.18e-02 1998 4 3 0.750 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.25e-02 217 4 2 0.500 0.009 TF:M04307_1 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 1 1 Q9GZN8,Q8NI77 67 2.26e-02 2024 4 3 0.750 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.32e-02 2043 4 3 0.750 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.36e-02 2055 4 3 0.750 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.42e-02 2072 4 3 0.750 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.50e-02 730 4 2 0.500 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q12972,Q8NI77 67 2.52e-02 733 4 2 0.500 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q12972,Q8NI77 67 2.55e-02 2110 4 3 0.750 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.58e-02 2119 4 3 0.750 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.62e-02 2130 4 3 0.750 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.69e-02 2151 4 3 0.750 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.70e-02 2154 4 3 0.750 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.72e-02 2159 4 3 0.750 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.78e-02 2176 4 3 0.750 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.82e-02 2188 4 3 0.750 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.83e-02 2191 4 3 0.750 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.84e-02 781 4 2 0.500 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q12972,Q8NI77 67 2.85e-02 2197 4 3 0.750 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.90e-02 2209 4 3 0.750 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 2.92e-02 2215 4 3 0.750 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 2.93e-02 794 4 2 0.500 0.003 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 Q12972,Q8NI77 67 2.96e-02 798 4 2 0.500 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 Q12972,Q8NI77 67 2.97e-02 2227 4 3 0.750 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q12972,Q8NI77,P62136 67 3.13e-02 2270 4 3 0.750 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.15e-02 2274 4 3 0.750 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.15e-02 2274 4 3 0.750 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.17e-02 2279 4 3 0.750 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.17e-02 2281 4 3 0.750 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.19e-02 2286 4 3 0.750 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.23e-02 2295 4 3 0.750 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 Q12972,Q8NI77 67 3.28e-02 2308 4 3 0.750 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.29e-02 2310 4 3 0.750 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.36e-02 2328 4 3 0.750 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.42e-02 2342 4 3 0.750 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.52e-02 2366 4 3 0.750 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.56e-02 879 4 2 0.500 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q12972,Q8NI77 67 3.60e-02 2385 4 3 0.750 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.65e-02 2397 4 3 0.750 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.77e-02 2425 4 3 0.750 0.001 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.79e-02 2429 4 3 0.750 0.001 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.81e-02 2435 4 3 0.750 0.001 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q12972,Q8NI77 67 3.87e-02 919 4 2 0.500 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q12972,Q8NI77 67 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 Q12972,Q8NI77 67 3.90e-02 2454 4 3 0.750 0.001 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.90e-02 2456 4 3 0.750 0.001 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.91e-02 2458 4 3 0.750 0.001 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.96e-02 930 4 2 0.500 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q12972,Q8NI77 67 3.96e-02 2469 4 3 0.750 0.001 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 3.98e-02 2472 4 3 0.750 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.00e-02 2477 4 3 0.750 0.001 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q12972,Q8NI77 67 4.08e-02 2495 4 3 0.750 0.001 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.08e-02 2496 4 3 0.750 0.001 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.13e-02 2505 4 3 0.750 0.001 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.17e-02 10 4 1 0.250 0.100 TF:M06973_1 tf 1 Factor: Smad5; motif: AKGTCTAGACCW; match class: 1 1 P62136 67 4.17e-02 10 4 1 0.250 0.100 TF:M06929_1 tf 1 Factor: Smad8; motif: AKGTCTAGACCW; match class: 1 1 P62136 67 4.17e-02 10 4 1 0.250 0.100 TF:M06929_0 tf 1 Factor: Smad8; motif: AKGTCTAGACCW; match class: 0 1 P62136 67 4.18e-02 958 4 2 0.500 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q12972,Q8NI77 67 4.20e-02 54 4 1 0.250 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 P62136 67 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q12972,Q8NI77 67 4.32e-02 2547 4 3 0.750 0.001 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q12972,Q8NI77,P62136 67 4.34e-02 977 4 2 0.500 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q12972,Q8NI77 67 4.55e-02 1002 4 2 0.500 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q12972,Q8NI77 67 4.58e-02 59 4 1 0.250 0.017 KEGG:04720 keg 1 Long-term potentiation 1 P62136 67 4.72e-02 1256 4 3 0.750 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 Q9GZN8,Q8NI77,P62136 67 5.00e-02 1 4 1 0.250 1.000 GO:0036496 BP 1 regulation of translational initiation by eIF2 alpha dephosphorylation 1 P62136 67 5.00e-02 12 4 1 0.250 0.083 TF:M03865_1 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 1 1 Q8NI77 67 5.00e-02 14 4 1 0.250 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P62136 67 5.00e-02 1 4 1 0.250 1.000 GO:0070463 MF 1 tubulin-dependent ATPase activity 1 Q8NI77 67 5.00e-02 29 4 1 0.250 0.034 CORUM:1183 cor 1 CDC5L complex 1 P62136 67 5.00e-02 1 4 1 0.250 1.000 GO:0008995 MF 1 ribonuclease E activity 1 Q12972 68 1.79e-03 1 3 1 0.333 1.000 GO:0042658 MF 1 MHC class II protein binding, via antigen binding groove 1 P04233 68 1.79e-03 1 3 1 0.333 1.000 GO:0035718 MF 1 macrophage migration inhibitory factor binding 1 P04233 68 3.58e-03 2 3 1 0.333 0.500 GO:0035692 CC 1 macrophage migration inhibitory factor receptor complex 1 P04233 68 3.58e-03 2 3 1 0.333 0.500 GO:0042289 MF 1 MHC class II protein binding 1 P04233 68 5.37e-03 3 3 1 0.333 0.333 GO:0060907 BP 1 positive regulation of macrophage cytokine production 1 P04233 68 5.37e-03 3 3 1 0.333 0.333 GO:2000343 BP 1 positive regulation of chemokine (C-X-C motif) ligand 2 production 1 P04233 68 7.16e-03 4 3 1 0.333 0.250 GO:0061081 BP 1 positive regulation of myeloid leukocyte cytokine production involved in immune response 1 P04233 68 8.95e-03 5 3 1 0.333 0.200 GO:0010935 BP 1 regulation of macrophage cytokine production 1 P04233 68 8.95e-03 5 3 1 0.333 0.200 GO:2000341 BP 1 regulation of chemokine (C-X-C motif) ligand 2 production 1 P04233 68 1.07e-02 6 3 1 0.333 0.167 GO:0010934 BP 1 macrophage cytokine production 1 P04233 68 1.25e-02 7 3 1 0.333 0.143 GO:0072567 BP 1 chemokine (C-X-C motif) ligand 2 production 1 P04233 68 1.43e-02 8 3 1 0.333 0.125 GO:0061082 BP 1 myeloid leukocyte cytokine production 1 P04233 68 1.61e-02 9 3 1 0.333 0.111 GO:0042613 CC 1 MHC class II protein complex 1 P04233 68 1.61e-02 9 3 1 0.333 0.111 GO:0019883 BP 1 antigen processing and presentation of endogenous antigen 1 P04233 68 1.61e-02 9 3 1 0.333 0.111 GO:0090023 BP 1 positive regulation of neutrophil chemotaxis 1 P04233 68 1.79e-02 10 3 1 0.333 0.100 GO:0044183 MF 1 protein binding involved in protein folding 1 P04233 68 1.79e-02 10 3 1 0.333 0.100 GO:1902624 BP 1 positive regulation of neutrophil migration 1 P04233 68 1.79e-02 10 3 1 0.333 0.100 GO:0045058 BP 1 T cell selection 1 P04233 68 1.79e-02 10 3 1 0.333 0.100 GO:0043518 BP 1 negative regulation of DNA damage response, signal transduction by p53 class mediator 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:1902165 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:0023023 MF 1 MHC protein complex binding 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:0043030 BP 1 regulation of macrophage activation 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:0071624 BP 1 positive regulation of granulocyte chemotaxis 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:1902166 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 P04233 68 1.97e-02 11 3 1 0.333 0.091 GO:0023026 MF 1 MHC class II protein complex binding 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0090022 BP 1 regulation of neutrophil chemotaxis 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0001516 BP 1 prostaglandin biosynthetic process 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0042287 MF 1 MHC protein binding 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0046457 BP 1 prostanoid biosynthetic process 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0030890 BP 1 positive regulation of B cell proliferation 1 P04233 68 2.15e-02 12 3 1 0.333 0.083 GO:0042611 CC 1 MHC protein complex 1 P04233 68 2.32e-02 13 3 1 0.333 0.077 GO:0002792 BP 1 negative regulation of peptide secretion 1 P04233 68 2.32e-02 13 3 1 0.333 0.077 GO:1902254 BP 1 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 P04233 68 2.50e-02 14 3 1 0.333 0.071 GO:1902253 BP 1 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 P04233 68 2.50e-02 14 3 1 0.333 0.071 GO:1902622 BP 1 regulation of neutrophil migration 1 P04233 68 2.68e-02 15 3 1 0.333 0.067 GO:0001961 BP 1 positive regulation of cytokine-mediated signaling pathway 1 P04233 68 2.68e-02 15 3 1 0.333 0.067 GO:0002720 BP 1 positive regulation of cytokine production involved in immune response 1 P04233 68 2.68e-02 15 3 1 0.333 0.067 GO:0071622 BP 1 regulation of granulocyte chemotaxis 1 P04233 68 2.86e-02 16 3 1 0.333 0.062 GO:0006692 BP 1 prostanoid metabolic process 1 P04233 68 2.86e-02 16 3 1 0.333 0.062 GO:0060760 BP 1 positive regulation of response to cytokine stimulus 1 P04233 68 2.86e-02 16 3 1 0.333 0.062 GO:0006693 BP 1 prostaglandin metabolic process 1 P04233 68 3.22e-02 18 3 1 0.333 0.056 GO:0030888 BP 1 regulation of B cell proliferation 1 P04233 68 3.22e-02 18 3 1 0.333 0.056 GO:0001540 MF 1 beta-amyloid binding 1 P04233 68 3.40e-02 19 3 1 0.333 0.053 GO:1901797 BP 1 negative regulation of signal transduction by p53 class mediator 1 P04233 68 3.40e-02 19 3 1 0.333 0.053 GO:0046456 BP 1 icosanoid biosynthetic process 1 P04233 68 3.40e-02 19 3 1 0.333 0.053 GO:1901570 BP 1 fatty acid derivative biosynthetic process 1 P04233 68 3.57e-02 20 3 1 0.333 0.050 GO:0098553 CC 1 lumenal side of endoplasmic reticulum membrane 1 P04233 68 3.57e-02 20 3 1 0.333 0.050 GO:0071556 CC 1 integral component of lumenal side of endoplasmic reticulum membrane 1 P04233 68 3.70e-02 70 3 1 0.333 0.014 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 P04233 68 3.75e-02 21 3 1 0.333 0.048 GO:1902230 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 P04233 68 3.75e-02 21 3 1 0.333 0.048 GO:0043516 BP 1 regulation of DNA damage response, signal transduction by p53 class mediator 1 P04233 68 3.93e-02 22 3 1 0.333 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 P04233 68 3.93e-02 22 3 1 0.333 0.045 GO:0042116 BP 1 macrophage activation 1 P04233 68 4.11e-02 23 3 1 0.333 0.043 GO:0002702 BP 1 positive regulation of production of molecular mediator of immune response 1 P04233 68 4.11e-02 23 3 1 0.333 0.043 GO:0016064 BP 1 immunoglobulin mediated immune response 1 P04233 68 4.11e-02 23 3 1 0.333 0.043 GO:0004896 MF 1 cytokine receptor activity 1 P04233 68 4.11e-02 23 3 1 0.333 0.043 GO:0032722 BP 1 positive regulation of chemokine production 1 P04233 68 4.19e-02 528 3 2 0.667 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 P04233,Q53R12 68 4.28e-02 534 3 2 0.667 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 P04233,Q53R12 68 4.29e-02 24 3 1 0.333 0.042 GO:0050871 BP 1 positive regulation of B cell activation 1 P04233 68 4.29e-02 24 3 1 0.333 0.042 GO:0030593 BP 1 neutrophil chemotaxis 1 P04233 68 4.29e-02 24 3 1 0.333 0.042 GO:1902229 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 P04233 68 4.29e-02 24 3 1 0.333 0.042 GO:0019724 BP 1 B cell mediated immunity 1 P04233 68 4.47e-02 25 3 1 0.333 0.040 GO:0002718 BP 1 regulation of cytokine production involved in immune response 1 P04233 68 4.64e-02 26 3 1 0.333 0.038 GO:0042771 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 P04233 68 5.00e-02 45 3 1 0.333 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P04233 68 5.00e-02 95 3 1 0.333 0.011 REAC:2132295 rea 1 MHC class II antigen presentation 1 P04233 68 5.00e-02 145 3 2 0.667 0.014 TF:M00978_1 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 1 1 P04233,Q3SXM5 68 5.00e-02 28 3 1 0.333 0.036 GO:0006636 BP 1 unsaturated fatty acid biosynthetic process 1 P04233 68 5.00e-02 28 3 1 0.333 0.036 GO:1990266 BP 1 neutrophil migration 1 P04233 68 5.00e-02 1 3 1 0.333 1.000 OMIM:615432 omi 1 SPECIFIC LANGUAGE IMPAIRMENT 5; SLI5 1 Q53R12 69 2.81e-07 3 2 2 1.000 0.667 GO:0005971 CC 1 ribonucleoside-diphosphate reductase complex 1 Q7LG56,P31350 69 2.81e-07 3 2 2 1.000 0.667 GO:0016728 MF 1 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 1 Q7LG56,P31350 69 2.81e-07 3 2 2 1.000 0.667 GO:0061731 MF 1 ribonucleoside-diphosphate reductase activity 1 Q7LG56,P31350 69 2.81e-07 3 2 2 1.000 0.667 GO:0004748 MF 1 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 1 Q7LG56,P31350 69 1.97e-06 7 2 2 1.000 0.286 GO:0009263 BP 1 deoxyribonucleotide biosynthetic process 1 Q7LG56,P31350 69 1.97e-06 7 2 2 1.000 0.286 GO:0016725 MF 1 oxidoreductase activity, acting on CH or CH2 groups 1 Q7LG56,P31350 69 2.17e-05 22 2 2 1.000 0.091 GO:0009262 BP 1 deoxyribonucleotide metabolic process 1 Q7LG56,P31350 69 2.64e-05 25 2 2 1.000 0.080 REAC:499943 rea 1 Synthesis and interconversion of nucleotide di- and triphosphates 1 Q7LG56,P31350 69 3.05e-05 26 2 2 1.000 0.077 GO:0015949 BP 1 nucleobase-containing small molecule interconversion 1 Q7LG56,P31350 69 9.02e-05 45 2 2 1.000 0.044 KEGG:00480 keg 1 Glutathione metabolism 1 Q7LG56,P31350 69 1.40e-04 56 2 2 1.000 0.036 KEGG:04115 keg 1 p53 signaling pathway 1 Q7LG56,P31350 69 2.82e-04 78 2 2 1.000 0.026 GO:1990204 CC 1 oxidoreductase complex 1 Q7LG56,P31350 69 3.45e-04 89 2 2 1.000 0.022 REAC:15869 rea 1 Metabolism of nucleotides 1 Q7LG56,P31350 69 4.07e-04 95 2 2 1.000 0.021 KEGG:00240 keg 1 Pyrimidine metabolism 1 Q7LG56,P31350 69 8.36e-04 134 2 2 1.000 0.015 GO:0009165 BP 1 nucleotide biosynthetic process 1 Q7LG56,P31350 69 1.02e-03 148 2 2 1.000 0.014 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 Q7LG56,P31350 69 1.03e-03 151 2 2 1.000 0.013 KEGG:00230 keg 1 Purine metabolism 1 Q7LG56,P31350 69 1.85e-03 199 2 2 1.000 0.010 GO:0044445 CC 1 cytosolic part 1 Q7LG56,P31350 69 4.55e-03 1 2 1 0.500 1.000 OMIM:613077 omi 1 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT 5; PEOA5;;PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, AUTOSOMAL DOMINANT 5 1 Q7LG56 69 4.55e-03 1 2 1 0.500 1.000 OMIM:612075 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 8A (ENCEPHALOMYOPATHIC TYPE WITHRENAL TUBULOPATHY); MTDPS8A;;MITOCHONDRIAL DNA DEPLETION SYNDROME, ENCEPHALOMYOPATHIC, WITH RENALTUBULOPATHY, AUTOSOMAL RECESSIVEMITOCHONDRIAL DNA DEPLETION SYNDROME 8B (MNGIE TYPE), INCLUDED; MTDPS8B,INCLUDED;;MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME, RRM2B-RELATED,INCLUDED;;MNGIE, RRM2B-RELATED, INCLUDED 1 Q7LG56 69 5.22e-03 334 2 2 1.000 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 Q7LG56,P31350 69 7.04e-03 388 2 2 1.000 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 Q7LG56,P31350 69 7.41e-03 398 2 2 1.000 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 Q7LG56,P31350 69 9.48e-03 450 2 2 1.000 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 Q7LG56,P31350 69 1.02e-02 466 2 2 1.000 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q7LG56,P31350 69 1.08e-02 480 2 2 1.000 0.004 GO:0016491 MF 1 oxidoreductase activity 1 Q7LG56,P31350 69 1.14e-02 18 2 1 0.500 0.056 REAC:69205 rea 1 G1/S-Specific Transcription 1 P31350 69 1.37e-02 3 2 1 0.500 0.333 HP:0002254 hp 1 Intermittent diarrhea 1 Q7LG56 69 1.37e-02 3 2 1 0.500 0.333 HP:0100613 hp 1 Death in early adulthood 1 Q7LG56 69 2.13e-02 674 2 2 1.000 0.003 GO:0019637 BP 1 organophosphate metabolic process 1 Q7LG56,P31350 69 2.16e-02 34 2 1 0.500 0.029 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 P31350 69 2.28e-02 5 2 1 0.500 0.200 HP:0003434 hp 1 Sensory ataxic neuropathy 1 Q7LG56 69 2.38e-02 22 2 1 0.500 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 P31350 69 2.73e-02 6 2 1 0.500 0.167 HP:0006858 hp 1 Impaired distal proprioception 1 Q7LG56 69 2.73e-02 6 2 1 0.500 0.167 HP:0002578 hp 1 Gastroparesis 1 Q7LG56 69 2.73e-02 6 2 1 0.500 0.167 OMIM:157640 omi 1 Autosomal Dominant Progressive External Ophthalmoplegia with DNA Deletions 1 Q7LG56 69 2.98e-02 798 2 2 1.000 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q7LG56,P31350 69 3.18e-02 7 2 1 0.500 0.143 HP:0004326 hp 1 Cachexia 1 Q7LG56 69 3.18e-02 7 2 1 0.500 0.143 HP:0001709 hp 1 Third degree atrioventricular block 1 Q7LG56 69 3.18e-02 7 2 1 0.500 0.143 HP:0003689 hp 1 Multiple mitochondrial DNA deletions 1 Q7LG56 69 3.18e-02 7 2 1 0.500 0.143 HP:0009141 hp 1 Depletion of mitochondrial DNA in muscle tissue 1 Q7LG56 69 3.39e-02 851 2 2 1.000 0.002 GO:0044711 BP 1 single-organism biosynthetic process 1 Q7LG56,P31350 69 3.64e-02 8 2 1 0.500 0.125 HP:0003548 hp 1 Subsarcolemmal accumulations of abnormally shaped mitochondria 1 Q7LG56 69 4.55e-02 10 2 1 0.500 0.100 HP:0003713 hp 1 Muscle fiber necrosis 1 Q7LG56 69 4.55e-02 10 2 1 0.500 0.100 HP:0003750 hp 1 Increased muscle fatiguability 1 Q7LG56 69 4.55e-02 10 2 1 0.500 0.100 HP:0004395 hp 1 Malnutrition 1 Q7LG56 69 5.00e-02 1033 2 2 1.000 0.002 GO:1902494 CC 1 catalytic complex 1 Q7LG56,P31350 69 5.00e-02 11 2 1 0.500 0.091 HP:0006886 hp 1 Impaired distal vibration sensation 1 Q7LG56 69 5.00e-02 11 2 1 0.500 0.091 HP:0001924 hp 1 Sideroblastic anemia 1 Q7LG56 69 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 Q7LG56,P31350 69 5.00e-02 11 2 1 0.500 0.091 HP:0010871 hp 1 Sensory ataxia 1 Q7LG56 69 5.00e-02 348 2 2 1.000 0.006 TF:M01001_1 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 1 1 Q7LG56,P31350 69 5.00e-02 79 2 1 0.500 0.013 REAC:5628897 rea 1 TP53 Regulates Metabolic Genes 1 Q7LG56 69 5.00e-02 11 2 1 0.500 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 Q7LG56 70 2.03e-03 1 4 1 0.250 1.000 OMIM:615490 omi 1 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R; CMT2R;;CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 2R;;CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL RECESSIVE, TYPE 2R 1 Q9C040 70 2.14e-02 3 4 1 0.250 0.333 TF:M05774_0 tf 1 Factor: ZNF697; motif: KGGTACGAGGGM; match class: 0 1 Q15649 70 4.65e-02 1040 4 3 0.750 0.003 TF:M05882_0 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 0 1 Q9UHK0,Q8TAC9,Q15649 70 5.00e-02 22 4 1 0.250 0.045 HP:0002136 hp 1 Broad-based gait 1 Q9C040 70 5.00e-02 7 4 1 0.250 0.143 TF:M00023_1 tf 1 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN; match class: 1 1 Q9C040 70 5.00e-02 1 4 1 0.250 1.000 GO:0005726 CC 1 perichromatin fibrils 1 Q9UHK0 70 5.00e-02 25 4 1 0.250 0.040 OMIM:118210 omi 1 Charcot-Marie-Tooth Disease Type 2 1 Q9C040 70 5.00e-02 66 4 1 0.250 0.015 REAC:877300 rea 1 Interferon gamma signaling 1 Q9C040 71 9.11e-05 15 2 2 1.000 0.133 GO:0031163 BP 1 metallo-sulfur cluster assembly 1 O76071,Q9H5X1 71 9.11e-05 15 2 2 1.000 0.133 GO:0016226 BP 1 iron-sulfur cluster assembly 1 O76071,Q9H5X1 71 6.51e-03 123 2 2 1.000 0.016 GO:0051188 BP 1 cofactor biosynthetic process 1 O76071,Q9H5X1 71 3.08e-02 267 2 2 1.000 0.007 GO:0051186 BP 1 cofactor metabolic process 1 O76071,Q9H5X1 71 3.56e-02 287 2 2 1.000 0.007 GO:0006790 BP 1 sulfur compound metabolic process 1 O76071,Q9H5X1 71 4.00e-02 4 2 1 0.500 0.250 GO:0097361 CC 1 CIA complex 1 O76071 71 4.98e-02 469 2 2 1.000 0.004 MI:hsa-miR-891b mi 1 MI:hsa-miR-891b 1 O76071,Q9H5X1 71 5.00e-02 5 2 1 0.500 0.200 GO:0071817 CC 1 MMXD complex 1 O76071 71 5.00e-02 12 2 1 0.500 0.083 REAC:2564830 rea 1 Cytosolic iron-sulfur cluster assembly 1 O76071 71 5.00e-02 321 2 2 1.000 0.006 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 O76071,Q9H5X1 71 5.00e-02 470 2 2 1.000 0.004 MI:mmu-miR-710 mi 1 MI:mmu-miR-710 1 O76071,Q9H5X1 72 2.83e-03 467 2 2 1.000 0.004 TF:M01258_1 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 1 1 Q8IVD9,O94889 72 3.45e-03 516 2 2 1.000 0.004 TF:M02054_1 tf 1 Factor: ELF2; motif: CCCGGAARYN; match class: 1 1 Q8IVD9,O94889 72 7.27e-03 22 2 1 0.500 0.045 TF:M06216_0 tf 1 Factor: ZNF33a; motif: NTGTGCAAMGGA; match class: 0 1 O94889 72 1.00e-02 879 2 2 1.000 0.002 TF:M02066_1 tf 1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 1 Q8IVD9,O94889 72 1.46e-02 1062 2 2 1.000 0.002 TF:M07209_0 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 0 1 Q8IVD9,O94889 72 1.78e-02 1169 2 2 1.000 0.002 TF:M03972_0 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 0 1 Q8IVD9,O94889 72 1.85e-02 56 2 1 0.500 0.018 TF:M02058_1 tf 1 Factor: SAP1A; motif: NCCGGAARYN; match class: 1 1 Q8IVD9 72 1.85e-02 56 2 1 0.500 0.018 TF:M03990_1 tf 1 Factor: GABPA; motif: ACCGGAAGTN; match class: 1 1 Q8IVD9 72 2.12e-02 1277 2 2 1.000 0.002 TF:M03987_0 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 0 1 Q8IVD9,O94889 72 2.24e-02 68 2 1 0.500 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 Q8IVD9 72 2.44e-02 74 2 1 0.500 0.014 TF:M02059_1 tf 1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 1 Q8IVD9 72 2.46e-02 1375 2 2 1.000 0.001 TF:M02074_1 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 1 Q8IVD9,O94889 72 2.61e-02 79 2 1 0.500 0.013 TF:M00991_1 tf 1 Factor: Cdx; motif: NAYNRHNARAKTHATAAA; match class: 1 1 O94889 72 3.10e-02 94 2 1 0.500 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 Q8IVD9 72 3.16e-02 96 2 1 0.500 0.010 TF:M05944_0 tf 1 Factor: ZNF552; motif: NWTTGCTGRMGA; match class: 0 1 Q8IVD9 72 3.34e-02 1603 2 2 1.000 0.001 TF:M01214_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q8IVD9,O94889 72 3.34e-02 1603 2 2 1.000 0.001 TF:M02055_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q8IVD9,O94889 72 3.50e-02 49 2 1 0.500 0.020 GO:0031463 CC 1 Cul3-RING ubiquitin ligase complex 1 O94889 72 3.62e-02 110 2 1 0.500 0.009 TF:M04097_1 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 1 1 O94889 72 3.79e-02 115 2 1 0.500 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 Q8IVD9 72 3.82e-02 1714 2 2 1.000 0.001 TF:M01752_0 tf 1 Factor: ERG; motif: ACCGGAART; match class: 0 1 Q8IVD9,O94889 72 3.86e-02 1723 2 2 1.000 0.001 TF:M02069_0 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 0 1 Q8IVD9,O94889 72 4.01e-02 1757 2 2 1.000 0.001 TF:M02056_1 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 1 Q8IVD9,O94889 72 4.18e-02 1793 2 2 1.000 0.001 TF:M04137_1 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 1 1 Q8IVD9,O94889 72 4.18e-02 1793 2 2 1.000 0.001 TF:M04122_1 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 1 1 Q8IVD9,O94889 72 4.18e-02 1793 2 2 1.000 0.001 TF:M04126_1 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 1 1 Q8IVD9,O94889 72 4.18e-02 1793 2 2 1.000 0.001 TF:M04135_1 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 1 1 Q8IVD9,O94889 72 4.18e-02 1793 2 2 1.000 0.001 TF:M04117_1 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 1 1 Q8IVD9,O94889 72 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q8IVD9 72 4.94e-02 1949 2 2 1.000 0.001 TF:M02067_1 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 1 1 Q8IVD9,O94889 72 4.97e-02 1956 2 2 1.000 0.001 TF:M07235_0 tf 1 Factor: ZEB1; motif: NCWCACCTG; match class: 0 1 Q8IVD9,O94889 72 5.00e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q8IVD9 72 5.00e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q8IVD9 72 5.00e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q8IVD9 72 5.00e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q8IVD9 72 5.00e-02 70 2 1 0.500 0.014 GO:0051082 MF 1 unfolded protein binding 1 Q8IVD9 73 1.39e-03 2459 4 4 1.000 0.002 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 3.14e-03 10 4 1 0.250 0.100 TF:M06338_0 tf 1 Factor: ZNF813; motif: NGGTTGGGCAGA; match class: 0 1 Q9UGP4 73 4.30e-03 3261 4 4 1.000 0.001 TF:M04030_0 tf 1 Factor: MEIS3; motif: NTGACAGN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 4.41e-03 1 4 1 0.250 1.000 GO:2000119 BP 1 negative regulation of sodium-dependent phosphate transport 1 Q6FHJ7 73 5.21e-03 383 4 2 0.500 0.005 TF:M00922_0 tf 1 Factor: SRF; motif: CCAWATAWGGMNMNG; match class: 0 1 Q9UGP4,Q93052 73 7.81e-03 118 4 2 0.500 0.017 GO:0090090 BP 1 negative regulation of canonical Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 73 8.82e-03 2 4 1 0.250 0.500 GO:0010966 BP 1 regulation of phosphate transport 1 Q6FHJ7 73 8.82e-03 2 4 1 0.250 0.500 GO:0044341 BP 1 sodium-dependent phosphate transport 1 Q6FHJ7 73 8.82e-03 2 4 1 0.250 0.500 GO:2000118 BP 1 regulation of sodium-dependent phosphate transport 1 Q6FHJ7 73 1.05e-02 137 4 2 0.500 0.015 GO:0030178 BP 1 negative regulation of Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 73 1.09e-02 4118 4 4 1.000 0.001 TF:M00471_0 tf 1 Factor: TBP; motif: TATAAATW; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 1.32e-02 3 4 1 0.250 0.333 GO:1902174 BP 1 positive regulation of keratinocyte apoptotic process 1 Q6FHJ7 73 1.44e-02 46 4 1 0.250 0.022 TF:M06596_0 tf 1 Factor: ZNF486; motif: GKGCCAACGC; match class: 0 1 Q6FHJ7 73 1.46e-02 2044 4 3 0.750 0.001 TF:M04326_0 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 0 1 Q06190,Q6FHJ7,Q93052 73 1.47e-02 162 4 2 0.500 0.012 GO:0060828 BP 1 regulation of canonical Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 73 1.59e-02 51 4 1 0.250 0.020 TF:M06129_0 tf 1 Factor: GLI4; motif: TGGTRAGRAARC; match class: 0 1 Q6FHJ7 73 1.61e-02 684 4 2 0.500 0.003 TF:M01591_1 tf 1 Factor: Tal-1; motif: CTTCCTTMTCTSY; match class: 1 1 Q6FHJ7,Q93052 73 1.63e-02 689 4 2 0.500 0.003 TF:M01596_0 tf 1 Factor: Gli3; motif: STGGGTGGYCY; match class: 0 1 Q9UGP4,Q93052 73 1.64e-02 4559 4 4 1.000 0.001 TF:M07409_0 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 1.93e-02 62 4 1 0.250 0.016 TF:M06525_0 tf 1 Factor: ZNF431; motif: NGKTWGGGCAGA; match class: 0 1 Q9UGP4 73 1.96e-02 2270 4 3 0.750 0.001 TF:M01739_0 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4 73 2.03e-02 771 4 2 0.500 0.003 TF:M01219_1 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 1 Q06190,Q9UGP4 73 2.04e-02 191 4 2 0.500 0.010 GO:0060070 BP 1 canonical Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 73 2.04e-02 773 4 2 0.500 0.003 TF:M07204_0 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 0 1 Q06190,Q6FHJ7 73 2.10e-02 786 4 2 0.500 0.003 TF:M00773_1 tf 1 Factor: c-MYB; motif: NNNGNCAGTTN; match class: 1 1 Q6FHJ7,Q93052 73 2.11e-02 2328 4 3 0.750 0.001 TF:M03834_0 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4 73 2.12e-02 27 4 1 0.250 0.037 KEGG:04392 keg 1 Hippo signaling pathway -multiple species 1 Q9UGP4 73 2.20e-02 5 4 1 0.250 0.200 GO:0006817 BP 1 phosphate ion transport 1 Q6FHJ7 73 2.26e-02 2384 4 3 0.750 0.001 TF:M00802_0 tf 1 Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 0 1 Q6FHJ7,Q9UGP4,Q93052 73 2.34e-02 75 4 1 0.250 0.013 TF:M05310_1 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 1 1 Q9UGP4 73 2.46e-02 210 4 2 0.500 0.010 GO:0030111 BP 1 regulation of Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 73 2.55e-02 82 4 1 0.250 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 Q9UGP4 73 2.63e-02 884 4 2 0.500 0.002 TF:M02090_0 tf 1 Factor: E2F-4; motif: GCGGGAAANA; match class: 0 1 Q06190,Q6FHJ7 73 2.64e-02 6 4 1 0.250 0.167 GO:0035331 BP 1 negative regulation of hippo signaling 1 Q9UGP4 73 2.64e-02 6 4 1 0.250 0.167 GO:1902172 BP 1 regulation of keratinocyte apoptotic process 1 Q6FHJ7 73 2.64e-02 6 4 1 0.250 0.167 GO:0097283 BP 1 keratinocyte apoptotic process 1 Q6FHJ7 73 2.64e-02 6 4 1 0.250 0.167 GO:0002076 BP 1 osteoblast development 1 Q9UGP4 73 2.68e-02 86 4 1 0.250 0.012 TF:M06108_0 tf 1 Factor: ZNF43; motif: NCTKGTTGGTGM; match class: 0 1 Q93052 73 2.71e-02 87 4 1 0.250 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 Q6FHJ7 73 2.74e-02 5180 4 4 1.000 0.001 TF:M03563_0 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 2.94e-02 2618 4 3 0.750 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q06190,Q6FHJ7,Q93052 73 2.96e-02 940 4 2 0.500 0.002 TF:M00513_1 tf 1 Factor: ATF3; motif: CBCTGACGTCANCS; match class: 1 1 Q6FHJ7,Q93052 73 3.08e-02 7 4 1 0.250 0.143 GO:0072505 BP 1 divalent inorganic anion homeostasis 1 Q6FHJ7 73 3.08e-02 7 4 1 0.250 0.143 GO:0055062 BP 1 phosphate ion homeostasis 1 Q6FHJ7 73 3.08e-02 7 4 1 0.250 0.143 GO:0072506 BP 1 trivalent inorganic anion homeostasis 1 Q6FHJ7 73 3.32e-02 107 4 1 0.250 0.009 TF:M01007_0 tf 1 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN; match class: 0 1 Q93052 73 3.35e-02 108 4 1 0.250 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q06190 73 3.50e-02 113 4 1 0.250 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q9UGP4 73 3.52e-02 5512 4 4 1.000 0.001 TF:M00806_0 tf 1 Factor: NF-1; motif: NTGGNNNNNNGCCAANN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 3.52e-02 8 4 1 0.250 0.125 GO:0035330 BP 1 regulation of hippo signaling 1 Q9UGP4 73 3.57e-02 115 4 1 0.250 0.009 TF:M01588_1 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 1 Q93052 73 3.62e-02 5554 4 4 1.000 0.001 TF:M01284_0 tf 1 Factor: SOX9; motif: RNACAAAGGVN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 3.77e-02 2861 4 3 0.750 0.001 TF:M02095_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 Q06190,Q6FHJ7,Q93052 73 3.88e-02 1086 4 2 0.500 0.002 TF:M01719_0 tf 1 Factor: OTX2; motif: NRANGGATTARNN; match class: 0 1 Q06190,Q93052 73 3.96e-02 9 4 1 0.250 0.111 GO:0016442 CC 1 RISC complex 1 Q9UGP4 73 3.96e-02 9 4 1 0.250 0.111 GO:0055083 BP 1 monovalent inorganic anion homeostasis 1 Q6FHJ7 73 3.96e-02 9 4 1 0.250 0.111 GO:0031332 CC 1 RNAi effector complex 1 Q9UGP4 73 3.96e-02 9 4 1 0.250 0.111 GO:0045606 BP 1 positive regulation of epidermal cell differentiation 1 Q6FHJ7 73 3.99e-02 1102 4 2 0.500 0.002 TF:M00471_1 tf 1 Factor: TBP; motif: TATAAATW; match class: 1 1 Q06190,Q6FHJ7 73 4.13e-02 1122 4 2 0.500 0.002 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 Q9UGP4,Q93052 73 4.15e-02 134 4 1 0.250 0.007 TF:M00186_0 tf 1 Factor: SRF; motif: GNCCAWATAWGGMN; match class: 0 1 Q93052 73 4.18e-02 135 4 1 0.250 0.007 TF:M06508_0 tf 1 Factor: ZNF114; motif: GGCCGGSTAA; match class: 0 1 Q06190 73 4.33e-02 140 4 1 0.250 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q06190 73 4.33e-02 3006 4 3 0.750 0.001 TF:M03920_1 tf 1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 1 Q06190,Q6FHJ7,Q93052 73 4.39e-02 1159 4 2 0.500 0.002 TF:M01588_0 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 0 1 Q06190,Q93052 73 4.40e-02 10 4 1 0.250 0.100 GO:1904037 BP 1 positive regulation of epithelial cell apoptotic process 1 Q6FHJ7 73 4.44e-02 63 4 1 0.250 0.016 REAC:1234176 rea 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 1 Q9UGP4 73 4.48e-02 145 4 1 0.250 0.007 TF:M07264_1 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 1 1 Q6FHJ7 73 4.72e-02 153 4 1 0.250 0.007 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 Q93052 73 4.82e-02 5964 4 4 1.000 0.001 TF:M04027_0 tf 1 Factor: MEIS1; motif: NTGACAN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 4.83e-02 5967 4 4 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 Q06190,Q6FHJ7,Q9UGP4,Q93052 73 4.84e-02 11 4 1 0.250 0.091 GO:1903792 BP 1 negative regulation of anion transport 1 Q6FHJ7 73 4.84e-02 11 4 1 0.250 0.091 GO:0045684 BP 1 positive regulation of epidermis development 1 Q6FHJ7 73 5.00e-02 162 4 1 0.250 0.006 TF:M00249_1 tf 1 Factor: CHOP:C/EBPalpha; motif: NNRTGCAATMCCC; match class: 1 1 Q93052 73 5.00e-02 29 4 1 0.250 0.034 HP:0004808 hp 1 Acute myeloid leukemia 1 Q93052 73 5.00e-02 71 4 1 0.250 0.014 REAC:1234174 rea 1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 1 Q9UGP4 73 5.00e-02 301 4 2 0.500 0.007 GO:0198738 BP 1 cell-cell signaling by wnt 1 Q6FHJ7,Q9UGP4 73 5.00e-02 71 4 1 0.250 0.014 REAC:2262749 rea 1 Cellular response to hypoxia 1 Q9UGP4 73 5.00e-02 17 4 1 0.250 0.059 OMIM:601626 omi 1 LEUKEMIA, ACUTE MYELOID; AML;;LEUKEMIA, ACUTE MYELOGENOUSLEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO, INCLUDED 1 Q93052 73 5.00e-02 3 4 1 0.250 0.333 CORUM:1544 cor 1 PPP2CA-PPP2R1A-PPP2R3A complex 1 Q06190 73 5.00e-02 301 4 2 0.500 0.007 GO:0016055 BP 1 Wnt signaling pathway 1 Q6FHJ7,Q9UGP4 74 4.94e-07 24 6 3 0.500 0.125 GO:0090383 BP 1 phagosome acidification 1 Q9Y5K8,P15313,P36543 74 9.26e-07 22 6 3 0.500 0.136 REAC:77387 rea 1 Insulin receptor recycling 1 Q9Y5K8,P15313,P36543 74 9.90e-07 30 6 3 0.500 0.100 GO:0033572 BP 1 transferrin transport 1 Q9Y5K8,P15313,P36543 74 9.90e-07 30 6 3 0.500 0.100 GO:0015682 BP 1 ferric iron transport 1 Q9Y5K8,P15313,P36543 74 9.90e-07 30 6 3 0.500 0.100 GO:0072512 BP 1 trivalent inorganic cation transport 1 Q9Y5K8,P15313,P36543 74 9.90e-07 30 6 3 0.500 0.100 GO:0051452 BP 1 intracellular pH reduction 1 Q9Y5K8,P15313,P36543 74 1.10e-06 31 6 3 0.500 0.097 GO:0045851 BP 1 pH reduction 1 Q9Y5K8,P15313,P36543 74 1.10e-06 31 6 3 0.500 0.097 GO:0090382 BP 1 phagosome maturation 1 Q9Y5K8,P15313,P36543 74 1.38e-06 25 6 3 0.500 0.120 REAC:917977 rea 1 Transferrin endocytosis and recycling 1 Q9Y5K8,P15313,P36543 74 1.46e-06 34 6 3 0.500 0.088 GO:0016469 CC 1 proton-transporting two-sector ATPase complex 1 Q9Y5K8,P15313,P36543 74 1.56e-06 26 6 3 0.500 0.115 REAC:1222556 rea 1 ROS, RNS production in response to bacteria 1 Q9Y5K8,P15313,P36543 74 1.74e-06 36 6 3 0.500 0.083 GO:0006826 BP 1 iron ion transport 1 Q9Y5K8,P15313,P36543 74 2.78e-06 23 6 3 0.500 0.130 KEGG:04966 keg 1 Collecting duct acid secretion 1 Q9Y5K8,P15313,P36543 74 4.65e-06 37 6 3 0.500 0.081 REAC:917937 rea 1 Iron uptake and transport 1 Q9Y5K8,P15313,P36543 74 7.10e-06 57 6 3 0.500 0.053 GO:0051453 BP 1 regulation of intracellular pH 1 Q9Y5K8,P15313,P36543 74 7.48e-06 58 6 3 0.500 0.052 GO:0030641 BP 1 regulation of cellular pH 1 Q9Y5K8,P15313,P36543 74 8.29e-06 60 6 3 0.500 0.050 GO:0000041 BP 1 transition metal ion transport 1 Q9Y5K8,P15313,P36543 74 8.72e-06 61 6 3 0.500 0.049 GO:0006885 BP 1 regulation of pH 1 Q9Y5K8,P15313,P36543 74 1.50e-05 73 6 3 0.500 0.041 GO:0030004 BP 1 cellular monovalent inorganic cation homeostasis 1 Q9Y5K8,P15313,P36543 74 1.91e-05 79 6 3 0.500 0.038 GO:0008286 BP 1 insulin receptor signaling pathway 1 Q9Y5K8,P15313,P36543 74 2.20e-05 45 6 3 0.500 0.067 KEGG:05110 keg 1 Vibrio cholerae infection 1 Q9Y5K8,P15313,P36543 74 2.30e-05 84 6 3 0.500 0.036 GO:0055067 BP 1 monovalent inorganic cation homeostasis 1 Q9Y5K8,P15313,P36543 74 3.22e-05 51 6 3 0.500 0.059 KEGG:05323 keg 1 Rheumatoid arthritis 1 Q9Y5K8,P15313,P36543 74 3.25e-05 338 6 4 0.667 0.012 GO:0055082 BP 1 cellular chemical homeostasis 1 Q9Y5K8,P15313,P36543,P19367 74 3.42e-05 52 6 3 0.500 0.058 KEGG:04721 keg 1 Synaptic vesicle cycle 1 Q9Y5K8,P15313,P36543 74 3.77e-05 99 6 3 0.500 0.030 GO:0016241 BP 1 regulation of macroautophagy 1 Q9Y5K8,P15313,P36543 74 3.88e-05 11 6 2 0.333 0.182 GO:0033176 CC 1 proton-transporting V-type ATPase complex 1 Q9Y5K8,P15313 74 4.76e-05 58 6 3 0.500 0.052 KEGG:05120 keg 1 Epithelial cell signaling in Helicobacter pylori infection 1 Q9Y5K8,P15313,P36543 74 5.04e-05 109 6 3 0.500 0.028 GO:0032869 BP 1 cellular response to insulin stimulus 1 Q9Y5K8,P15313,P36543 74 5.45e-05 385 6 4 0.667 0.010 GO:0019725 BP 1 cellular homeostasis 1 Q9Y5K8,P15313,P36543,P19367 74 5.77e-05 114 6 3 0.500 0.026 GO:0032868 BP 1 response to insulin 1 Q9Y5K8,P15313,P36543 74 1.68e-04 512 6 4 0.667 0.008 GO:0048878 BP 1 chemical homeostasis 1 Q9Y5K8,P15313,P36543,P19367 74 1.78e-04 166 6 3 0.500 0.018 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 Q9Y5K8,P15313,P36543 74 1.98e-04 172 6 3 0.500 0.017 GO:1901653 BP 1 cellular response to peptide 1 Q9Y5K8,P15313,P36543 74 2.30e-04 181 6 3 0.500 0.017 GO:0043434 BP 1 response to peptide hormone 1 Q9Y5K8,P15313,P36543 74 2.66e-04 190 6 3 0.500 0.016 GO:1901652 BP 1 response to peptide 1 Q9Y5K8,P15313,P36543 74 3.17e-04 109 6 3 0.500 0.028 KEGG:00190 keg 1 Oxidative phosphorylation 1 Q9Y5K8,P15313,P36543 74 3.24e-04 203 6 3 0.500 0.015 GO:0016236 BP 1 macroautophagy 1 Q9Y5K8,P15313,P36543 74 3.43e-04 207 6 3 0.500 0.014 GO:0010506 BP 1 regulation of autophagy 1 Q9Y5K8,P15313,P36543 74 3.65e-04 157 6 3 0.500 0.019 REAC:983712 rea 1 Ion channel transport 1 Q9Y5K8,P15313,P36543 74 3.89e-04 216 6 3 0.500 0.014 GO:0005774 CC 1 vacuolar membrane 1 Q9Y5K8,P15313,P36543 74 4.64e-04 124 6 3 0.500 0.024 KEGG:04145 keg 1 Phagosome 1 Q9Y5K8,P15313,P36543 74 5.47e-04 493 6 4 0.667 0.008 REAC:382551 rea 1 Transmembrane transport of small molecules 1 Q9Y5K8,P15313,P36543,P19367 74 5.85e-04 134 6 3 0.500 0.022 KEGG:04150 keg 1 mTOR signaling pathway 1 Q9Y5K8,P15313,P36543 74 6.75e-04 260 6 3 0.500 0.012 GO:0071417 BP 1 cellular response to organonitrogen compound 1 Q9Y5K8,P15313,P36543 74 8.31e-04 279 6 3 0.500 0.011 GO:0044437 CC 1 vacuolar part 1 Q9Y5K8,P15313,P36543 74 8.85e-04 285 6 3 0.500 0.011 GO:0030003 BP 1 cellular cation homeostasis 1 Q9Y5K8,P15313,P36543 74 8.87e-04 783 6 4 0.667 0.005 GO:0042592 BP 1 homeostatic process 1 Q9Y5K8,P15313,P36543,P19367 74 9.41e-04 291 6 3 0.500 0.010 GO:0006873 BP 1 cellular ion homeostasis 1 Q9Y5K8,P15313,P36543 74 9.62e-04 53 6 2 0.333 0.038 GO:0015992 BP 1 proton transport 1 P15313,P36543 74 1.04e-03 55 6 2 0.333 0.036 GO:0006818 BP 1 hydrogen transport 1 P15313,P36543 74 1.10e-03 307 6 3 0.500 0.010 GO:0010243 BP 1 response to organonitrogen compound 1 Q9Y5K8,P15313,P36543 74 1.15e-03 311 6 3 0.500 0.010 GO:0055080 BP 1 cation homeostasis 1 Q9Y5K8,P15313,P36543 74 1.15e-03 311 6 3 0.500 0.010 GO:0032870 BP 1 cellular response to hormone stimulus 1 Q9Y5K8,P15313,P36543 74 1.19e-03 315 6 3 0.500 0.010 GO:1901699 BP 1 cellular response to nitrogen compound 1 Q9Y5K8,P15313,P36543 74 1.23e-03 319 6 3 0.500 0.009 GO:0098771 BP 1 inorganic ion homeostasis 1 Q9Y5K8,P15313,P36543 74 1.49e-03 340 6 3 0.500 0.009 GO:0006914 BP 1 autophagy 1 Q9Y5K8,P15313,P36543 74 1.57e-03 346 6 3 0.500 0.009 GO:0030001 BP 1 metal ion transport 1 Q9Y5K8,P15313,P36543 74 1.58e-03 347 6 3 0.500 0.009 GO:0050801 BP 1 ion homeostasis 1 Q9Y5K8,P15313,P36543 74 1.65e-03 352 6 3 0.500 0.009 GO:0009725 BP 1 response to hormone 1 Q9Y5K8,P15313,P36543 74 1.67e-03 263 6 3 0.500 0.011 REAC:74752 rea 1 Signaling by Insulin receptor 1 Q9Y5K8,P15313,P36543 74 2.03e-03 378 6 3 0.500 0.008 GO:1901698 BP 1 response to nitrogen compound 1 Q9Y5K8,P15313,P36543 74 2.08e-03 2689 6 5 0.833 0.002 TF:M06190_1 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 1 1 O75391,Q9Y5K8,P36543,P19367,Q9BW30 74 2.08e-03 2689 6 5 0.833 0.002 TF:M06191_1 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 1 1 O75391,Q9Y5K8,P36543,P19367,Q9BW30 74 2.30e-03 394 6 3 0.500 0.008 GO:0005773 CC 1 vacuole 1 Q9Y5K8,P15313,P36543 74 2.47e-03 85 6 2 0.333 0.024 GO:0016324 CC 1 apical plasma membrane 1 P15313,P36543 74 2.69e-03 416 6 3 0.500 0.007 GO:0034220 BP 1 ion transmembrane transport 1 Q9Y5K8,P15313,P36543 74 3.00e-03 432 6 3 0.500 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q9Y5K8,P15313,P36543 74 3.17e-03 440 6 3 0.500 0.007 GO:0006812 BP 1 cation transport 1 Q9Y5K8,P15313,P36543 74 3.25e-03 444 6 3 0.500 0.007 GO:0098796 CC 1 membrane protein complex 1 Q9Y5K8,P15313,P36543 74 3.25e-03 444 6 3 0.500 0.007 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 Q9Y5K8,P15313,P36543 74 3.30e-03 1100 6 4 0.667 0.004 GO:0045184 BP 1 establishment of protein localization 1 Q9Y5K8,P15313,P36543,P19367 74 3.63e-03 103 6 2 0.333 0.019 GO:0045177 CC 1 apical part of cell 1 P15313,P36543 74 4.16e-03 1477 6 4 0.667 0.003 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 4.71e-03 10 6 1 0.167 0.100 TF:M06520_0 tf 1 Factor: ZNF721; motif: NGTKGNGGGGGA; match class: 0 1 Q9BW30 74 4.89e-03 3 6 1 0.167 0.333 GO:0072656 BP 1 maintenance of protein location in mitochondrion 1 P19367 74 4.93e-03 840 6 3 0.500 0.004 TF:M00172_1 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 1 1 O75391,Q9Y5K8,P15313 74 5.04e-03 1 6 1 0.167 1.000 OMIM:267300 omi 1 RENAL TUBULAR ACIDOSIS, DISTAL, WITH PROGRESSIVE NERVE DEAFNESS;;RENAL TUBULAR ACIDOSIS, AUTOSOMAL RECESSIVE, WITH PROGRESSIVE NERVEDEAFNESS;;RENAL TUBULAR ACIDOSIS WITH PROGRESSIVE NERVE DEAFNESS;;RTA WITH PROGRESSIVE NERVE DEAFNESS 1 P15313 74 5.04e-03 1 6 1 0.167 1.000 OMIM:235700 omi 1 HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY 1 P19367 74 5.04e-03 1 6 1 0.167 1.000 OMIM:605285 omi 1 NEUROPATHY, HEREDITARY MOTOR AND SENSORY, RUSSE TYPE; HMSNR;;CHARCOT-MARIE-TOOTH DISEASE, TYPE 4G; CMT4G;;CHARCOT-MARIE-TOOTH DISEASE, AUTOSOMAL RECESSIVE, TYPE 4G;;HEREDITARY MOTOR AND SENSORY NEUROPATHY, RUSSE TYPE;;CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 4G 1 P19367 74 5.42e-03 529 6 3 0.500 0.006 GO:0055085 BP 1 transmembrane transport 1 Q9Y5K8,P15313,P36543 74 6.79e-03 798 6 3 0.500 0.004 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 Q9Y5K8,P36543,P19367 74 6.86e-03 944 6 3 0.500 0.003 TF:M00188_1 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 1 1 O75391,Q9Y5K8,P15313 74 7.22e-03 2018 6 4 0.667 0.002 TF:M07283_1 tf 1 Factor: ER-alpha; motif: GNCNNNNTGACCYN; match class: 1 1 O75391,P15313,P19367,Q9BW30 74 7.28e-03 586 6 3 0.500 0.005 GO:1901700 BP 1 response to oxygen-containing compound 1 Q9Y5K8,P15313,P36543 74 7.54e-03 593 6 3 0.500 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q9Y5K8,P15313,P36543 74 7.79e-03 1377 6 4 0.667 0.003 GO:0071702 BP 1 organic substance transport 1 Q9Y5K8,P15313,P36543,P19367 74 8.14e-03 1393 6 4 0.667 0.003 GO:0008104 BP 1 protein localization 1 Q9Y5K8,P15313,P36543,P19367 74 8.14e-03 5 6 1 0.167 0.200 GO:0008865 MF 1 fructokinase activity 1 P19367 74 8.14e-03 5 6 1 0.167 0.200 GO:0004340 MF 1 glucokinase activity 1 P19367 74 8.14e-03 5 6 1 0.167 0.200 GO:0019158 MF 1 mannokinase activity 1 P19367 74 8.14e-03 5 6 1 0.167 0.200 GO:0004396 MF 1 hexokinase activity 1 P19367 74 8.16e-03 307 6 2 0.333 0.007 TF:M06527_0 tf 1 Factor: ZNF675; motif: TGAAAGGGGA; match class: 0 1 P15313,P19367 74 9.52e-03 643 6 3 0.500 0.005 GO:0071495 BP 1 cellular response to endogenous stimulus 1 Q9Y5K8,P15313,P36543 74 9.62e-03 2181 6 4 0.667 0.002 TF:M03890_0 tf 1 Factor: TFEA; motif: GYCASVTGACYN; match class: 0 1 O75391,Q9Y5K8,P36543,Q9BW30 74 9.86e-03 21 6 1 0.167 0.048 TF:M06875_0 tf 1 Factor: ZNF224; motif: NTTGGAAAATGM; match class: 0 1 Q9Y5K8 74 1.01e-02 5 6 1 0.167 0.200 KEGG:00524 keg 1 Neomycin, kanamycin and gentamicin biosynthesis 1 P19367 74 1.13e-02 1932 6 4 0.667 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 1.20e-02 977 6 3 0.500 0.003 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q9Y5K8,P15313,P36543 74 1.21e-02 190 6 2 0.333 0.011 GO:0005765 CC 1 lysosomal membrane 1 Q9Y5K8,P36543 74 1.21e-02 190 6 2 0.333 0.011 GO:0098852 CC 1 lytic vacuole membrane 1 Q9Y5K8,P36543 74 1.27e-02 712 6 3 0.500 0.004 GO:0009719 BP 1 response to endogenous stimulus 1 Q9Y5K8,P15313,P36543 74 1.36e-02 201 6 2 0.333 0.010 GO:0015672 BP 1 monovalent inorganic cation transport 1 P15313,P36543 74 1.38e-02 2039 6 4 0.667 0.002 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 1.39e-02 733 6 3 0.500 0.004 GO:0006811 BP 1 ion transport 1 Q9Y5K8,P15313,P36543 74 1.40e-02 2049 6 4 0.667 0.002 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 1.43e-02 1618 6 4 0.667 0.002 GO:0033036 BP 1 macromolecule localization 1 Q9Y5K8,P15313,P36543,P19367 74 1.46e-02 1235 6 3 0.500 0.002 TF:M07210_0 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 0 1 P15313,P19367,Q9BW30 74 1.50e-02 32 6 1 0.167 0.031 TF:M05757_0 tf 1 Factor: ZNF648; motif: NGKGGCAGAATS; match class: 0 1 P36543 74 1.53e-02 759 6 3 0.500 0.004 GO:0098805 CC 1 whole membrane 1 Q9Y5K8,P15313,P36543 74 1.63e-02 10 6 1 0.167 0.100 GO:0016471 CC 1 vacuolar proton-transporting V-type ATPase complex 1 P15313 74 1.76e-02 1324 6 3 0.500 0.002 TF:M07231_0 tf 1 Factor: TFAP2A; motif: NNNNGCCYSAGGGCA; match class: 0 1 O75391,P15313,Q9BW30 74 1.80e-02 1333 6 3 0.500 0.002 TF:M07372_0 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 0 1 P15313,P36543,P19367 74 1.82e-02 1338 6 3 0.500 0.002 TF:M07054_1 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 1 P15313,P36543,Q9BW30 74 1.82e-02 2202 6 4 0.667 0.002 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q9Y5K8,P15313,P36543,P19367 74 1.83e-02 2601 6 4 0.667 0.002 TF:M02280_1 tf 1 Factor: AP1; motif: TGACTCA; match class: 1 1 O75391,Q9Y5K8,P15313,P19367 74 2.06e-02 2279 6 4 0.667 0.002 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 2.07e-02 2281 6 4 0.667 0.002 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 2.10e-02 45 6 1 0.167 0.022 TF:M06219_0 tf 1 Factor: ZNF266; motif: NGGWAAGTCCGY; match class: 0 1 Q9BW30 74 2.10e-02 503 6 2 0.333 0.004 TF:M03810_1 tf 1 Factor: RXR:PXR; motif: NNNTGAMCTYNNNTGAMCYN; match class: 1 1 O75391,P19367 74 2.11e-02 2295 6 4 0.667 0.002 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 2.11e-02 13 6 1 0.167 0.077 GO:0042472 BP 1 inner ear morphogenesis 1 P15313 74 2.15e-02 2308 6 4 0.667 0.002 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 2.16e-02 6716 6 6 1.000 0.001 TF:M06191_0 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 0 1 O75391,Q9Y5K8,P15313,P36543,P19367,Q9BW30 74 2.16e-02 6716 6 6 1.000 0.001 TF:M06190_0 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 0 1 O75391,Q9Y5K8,P15313,P36543,P19367,Q9BW30 74 2.24e-02 48 6 1 0.167 0.021 TF:M06103_0 tf 1 Factor: ZNF325; motif: NKGGCAAGAARM; match class: 0 1 Q9BW30 74 2.26e-02 1230 6 3 0.500 0.002 HPA:041010_12 hpa 1 spleen; cells in red pulp[Supportive,Medium] 1 P15313,P36543,P19367 74 2.38e-02 51 6 1 0.167 0.020 TF:M06423_0 tf 1 Factor: ZNF571; motif: NGKGWGGGCTGC; match class: 0 1 P15313 74 2.42e-02 2385 6 4 0.667 0.002 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 2.60e-02 16 6 1 0.167 0.062 GO:0042471 BP 1 ear morphogenesis 1 P15313 74 2.73e-02 1924 6 4 0.667 0.002 GO:0065008 BP 1 regulation of biological quality 1 Q9Y5K8,P15313,P36543,P19367 74 2.75e-02 580 6 2 0.333 0.003 TF:M04232_0 tf 1 Factor: FOXC1; motif: AARTAAAYAAACA; match class: 0 1 O75391,P36543 74 2.76e-02 2917 6 4 0.667 0.001 TF:M02078_1 tf 1 Factor: SPI1; motif: NGRGGAAGTN; match class: 1 1 Q9Y5K8,P15313,P36543,Q9BW30 74 2.80e-02 1568 6 3 0.500 0.002 TF:M03815_1 tf 1 Factor: c-Fos; motif: TGACTCAN; match class: 1 1 Q9Y5K8,P15313,P19367 74 2.85e-02 945 6 3 0.500 0.003 GO:0098588 CC 1 bounding membrane of organelle 1 Q9Y5K8,P15313,P36543 74 3.01e-02 964 6 3 0.500 0.003 GO:0015031 BP 1 protein transport 1 Q9Y5K8,P15313,P36543 74 3.06e-02 2547 6 4 0.667 0.002 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q9Y5K8,P15313,P36543,P19367 74 3.09e-02 19 6 1 0.167 0.053 GO:0019200 MF 1 carbohydrate kinase activity 1 P19367 74 3.16e-02 68 6 1 0.167 0.015 TF:M07223_1 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 1 1 P36543 74 3.18e-02 2574 6 4 0.667 0.002 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 Q9Y5K8,P15313,P36543,P19367 74 3.22e-02 1652 6 3 0.500 0.002 TF:M03820_1 tf 1 Factor: ER-alpha; motif: GGNNNNNNTGACCYN; match class: 1 1 P15313,P19367,Q9BW30 74 3.27e-02 1048 6 4 0.667 0.004 KEGG:01100 keg 1 Metabolic pathways 1 Q9Y5K8,P15313,P36543,P19367 74 3.29e-02 1665 6 3 0.500 0.002 TF:M01224_0 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 0 1 P15313,P36543,Q9BW30 74 3.33e-02 1672 6 3 0.500 0.002 TF:M04029_0 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 0 1 Q9Y5K8,P15313,P19367 74 3.33e-02 7222 6 6 1.000 0.001 TF:M01172_0 tf 1 Factor: PU.1; motif: NNNNYYYACTTCCTCTTTY; match class: 0 1 O75391,Q9Y5K8,P15313,P36543,P19367,Q9BW30 74 3.35e-02 72 6 1 0.167 0.014 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 Q9BW30 74 3.35e-02 320 6 2 0.333 0.006 GO:0098590 CC 1 plasma membrane region 1 P15313,P36543 74 3.41e-02 21 6 1 0.167 0.048 GO:0061512 BP 1 protein localization to cilium 1 Q9Y5K8 74 3.41e-02 21 6 1 0.167 0.048 GO:0048839 BP 1 inner ear development 1 P15313 74 3.43e-02 3100 6 4 0.667 0.001 TF:M00377_1 tf 1 Factor: Pax-4; motif: NAAWAATTANS; match class: 1 1 O75391,Q9Y5K8,P36543,P19367 74 3.43e-02 653 6 2 0.333 0.003 TF:M00173_1 tf 1 Factor: AP-1; motif: RSTGACTNANW; match class: 1 1 O75391,Q9Y5K8 74 3.44e-02 74 6 1 0.167 0.014 TF:M06627_0 tf 1 Factor: ZNF570; motif: NTGTWAARCATA; match class: 0 1 Q9Y5K8 74 3.47e-02 3111 6 4 0.667 0.001 TF:M03866_0 tf 1 Factor: c-Fos:c-Jun; motif: NTGACTCAN; match class: 0 1 O75391,Q9Y5K8,P15313,P19367 74 3.54e-02 1712 6 3 0.500 0.002 TF:M04619_0 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 0 1 P36543,P19367,Q9BW30 74 3.55e-02 1453 6 3 0.500 0.002 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9Y5K8,P15313,P36543 74 3.57e-02 22 6 1 0.167 0.045 GO:0072595 BP 1 maintenance of protein localization in organelle 1 P19367 74 3.67e-02 79 6 1 0.167 0.013 TF:M03974_1 tf 1 Factor: ERF; motif: ACCGGAAGTR; match class: 1 1 Q9Y5K8 74 3.71e-02 7351 6 6 1.000 0.001 TF:M00281_0 tf 1 Factor: RFX1; motif: NNGTNRCNATRGYAACNN; match class: 0 1 O75391,Q9Y5K8,P15313,P36543,P19367,Q9BW30 74 3.71e-02 80 6 1 0.167 0.013 TF:M07281_1 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 1 1 Q9BW30 74 3.73e-02 23 6 1 0.167 0.043 GO:0007588 BP 1 excretion 1 P15313 74 3.73e-02 23 6 1 0.167 0.043 GO:0016328 CC 1 lateral plasma membrane 1 P15313 74 3.81e-02 342 6 2 0.333 0.006 GO:0005764 CC 1 lysosome 1 Q9Y5K8,P36543 74 3.81e-02 342 6 2 0.333 0.006 GO:0000323 CC 1 lytic vacuole 1 Q9Y5K8,P36543 74 3.85e-02 694 6 2 0.333 0.003 TF:M03973_0 tf 1 Factor: ELK4; motif: ACCGGAARTN; match class: 0 1 O75391,Q9Y5K8 74 3.99e-02 86 6 1 0.167 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 P15313 74 3.99e-02 86 6 1 0.167 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 P19367 74 4.03e-02 87 6 1 0.167 0.011 TF:M07204_1 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 1 P36543 74 4.03e-02 712 6 2 0.333 0.003 TF:M04263_0 tf 1 Factor: FOXO4; motif: TTTCCCCACACG; match class: 0 1 Q9Y5K8,P15313 74 4.12e-02 720 6 2 0.333 0.003 TF:M02268_0 tf 1 Factor: INSM1; motif: TGYCAGGGGGCR; match class: 0 1 P15313,Q9BW30 74 4.15e-02 5107 6 5 0.833 0.001 TF:M03805_1 tf 1 Factor: YB-1; motif: CCAMTCNGMR; match class: 1 1 O75391,P15313,P36543,P19367,Q9BW30 74 4.20e-02 343 6 3 0.500 0.009 MI:mmu-miR-711 mi 1 MI:mmu-miR-711 1 P15313,P36543,P19367 74 4.22e-02 26 6 1 0.167 0.038 GO:0061621 BP 1 canonical glycolysis 1 P19367 74 4.22e-02 26 6 1 0.167 0.038 GO:0061615 BP 1 glycolytic process through fructose-6-phosphate 1 P19367 74 4.22e-02 26 6 1 0.167 0.038 GO:0006735 BP 1 NADH regeneration 1 P19367 74 4.22e-02 26 6 1 0.167 0.038 GO:0043583 BP 1 ear development 1 P15313 74 4.22e-02 26 6 1 0.167 0.038 GO:0061718 BP 1 glucose catabolic process to pyruvate 1 P19367 74 4.22e-02 26 6 1 0.167 0.038 GO:0061620 BP 1 glycolytic process through glucose-6-phosphate 1 P19367 74 4.30e-02 5147 6 5 0.833 0.001 TF:M00630_0 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 0 1 O75391,P15313,P36543,P19367,Q9BW30 74 4.39e-02 1574 6 3 0.500 0.002 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P15313,P36543,P19367 74 4.42e-02 2194 6 4 0.667 0.002 GO:0070062 CC 1 extracellular exosome 1 Q9Y5K8,P15313,P36543,Q9BW30 74 4.44e-02 750 6 2 0.333 0.003 TF:M03821_1 tf 1 Factor: ER-beta; motif: ANNSTGACCYRGNN; match class: 1 1 O75391,P15313 74 4.44e-02 96 6 1 0.167 0.010 TF:M00929_1 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 1 1 P15313 74 4.48e-02 2839 6 4 0.667 0.001 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 Q9Y5K8,P15313,P36543,P19367 74 4.49e-02 97 6 1 0.167 0.010 TF:M00068_0 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 0 1 Q9BW30 74 4.50e-02 2205 6 4 0.667 0.002 GO:1903561 CC 1 extracellular vesicle 1 Q9Y5K8,P15313,P36543,Q9BW30 74 4.50e-02 2205 6 4 0.667 0.002 GO:0043230 CC 1 extracellular organelle 1 Q9Y5K8,P15313,P36543,Q9BW30 74 4.54e-02 28 6 1 0.167 0.036 GO:0006007 BP 1 glucose catabolic process 1 P19367 74 4.62e-02 100 6 1 0.167 0.010 TF:M05668_0 tf 1 Factor: ZNF154; motif: NGTGAAATCAGA; match class: 0 1 P15313 74 4.69e-02 773 6 2 0.333 0.003 TF:M07204_0 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 0 1 O75391,P36543 74 4.70e-02 29 6 1 0.167 0.034 GO:0051220 BP 1 cytoplasmic sequestering of protein 1 P19367 74 4.70e-02 29 6 1 0.167 0.034 GO:0005902 CC 1 microvillus 1 P15313 74 4.71e-02 3396 6 4 0.667 0.001 TF:M00621_0 tf 1 Factor: C/EBPdelta; motif: MATTKCNTMAYY; match class: 0 1 O75391,Q9Y5K8,P19367,Q9BW30 74 4.85e-02 105 6 1 0.167 0.010 TF:M03984_0 tf 1 Factor: ETV6; motif: CCGGAASCGGAAGTR; match class: 0 1 Q9Y5K8 74 4.86e-02 30 6 1 0.167 0.033 GO:0006734 BP 1 NADH metabolic process 1 P19367 74 4.91e-02 2914 6 4 0.667 0.001 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 Q9Y5K8,P15313,P36543,P19367 74 4.94e-02 2262 6 4 0.667 0.002 GO:0006996 BP 1 organelle organization 1 Q9Y5K8,P15313,P36543,Q9BW30 74 5.00e-02 1157 6 3 0.500 0.003 GO:0071310 BP 1 cellular response to organic substance 1 Q9Y5K8,P15313,P36543 74 5.00e-02 25 6 1 0.167 0.040 KEGG:00052 keg 1 Galactose metabolism 1 P19367 74 5.00e-02 32 6 1 0.167 0.031 REAC:70171 rea 1 Glycolysis 1 P19367 74 5.00e-02 5 6 1 0.167 0.200 HP:0008341 hp 1 Distal renal tubular acidosis 1 P15313 74 5.00e-02 10 6 1 0.167 0.100 OMIM:214400 omi 1 Charcot-Marie-Tooth Disease Type 4 1 P19367 74 5.00e-02 5 6 1 0.167 0.200 HP:0001930 hp 1 Nonspherocytic hemolytic anemia 1 P19367 74 5.00e-02 364 6 3 0.500 0.008 MI:mmu-miR-689 mi 1 MI:mmu-miR-689 1 P15313,P19367,Q9BW30 74 5.00e-02 5 6 1 0.167 0.200 HP:0003450 hp 1 Axonal regeneration 1 P19367 75 6.81e-06 17 2 2 1.000 0.118 GO:0031904 CC 1 endosome lumen 1 Q9Y587,Q9Y6B7 75 9.79e-06 6 2 2 1.000 0.333 HP:0012811 hp 1 Wide nasal ridge 1 Q9Y587,Q9Y6B7 75 1.37e-05 7 2 2 1.000 0.286 HP:0000297 hp 1 Facial hypotonia 1 Q9Y587,Q9Y6B7 75 1.37e-05 7 2 2 1.000 0.286 HP:0000395 hp 1 Prominent antihelix 1 Q9Y587,Q9Y6B7 75 7.38e-05 35 2 2 1.000 0.057 REAC:432720 rea 1 Lysosome Vesicle Biogenesis 1 Q9Y587,Q9Y6B7 75 8.87e-05 17 2 2 1.000 0.118 HP:0100021 hp 1 Cerebral palsy 1 Q9Y587,Q9Y6B7 75 1.24e-04 71 2 2 1.000 0.028 GO:0032588 CC 1 trans-Golgi network membrane 1 Q9Y587,Q9Y6B7 75 1.37e-04 21 2 2 1.000 0.095 HP:0003189 hp 1 Long nose 1 Q9Y587,Q9Y6B7 75 1.80e-04 24 2 2 1.000 0.083 HP:0009738 hp 1 Abnormality of the antihelix 1 Q9Y587,Q9Y6B7 75 2.84e-04 30 2 2 1.000 0.067 HP:0002816 hp 1 Genu recurvatum 1 Q9Y587,Q9Y6B7 75 3.17e-04 72 2 2 1.000 0.028 REAC:421837 rea 1 Clathrin derived vesicle budding 1 Q9Y587,Q9Y6B7 75 3.17e-04 72 2 2 1.000 0.028 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 Q9Y587,Q9Y6B7 75 3.44e-04 33 2 2 1.000 0.061 HP:0003199 hp 1 Decreased muscle mass 1 Q9Y587,Q9Y6B7 75 4.11e-04 36 2 2 1.000 0.056 HP:0002518 hp 1 Abnormality of the periventricular white matter 1 Q9Y587,Q9Y6B7 75 4.35e-04 37 2 2 1.000 0.054 HP:0006957 hp 1 Loss of ability to walk 1 Q9Y587,Q9Y6B7 75 5.37e-04 147 2 2 1.000 0.014 GO:0005802 CC 1 trans-Golgi network 1 Q9Y587,Q9Y6B7 75 5.62e-04 42 2 2 1.000 0.048 HP:0002505 hp 1 Progressive inability to walk 1 Q9Y587,Q9Y6B7 75 7.11e-04 169 2 2 1.000 0.012 GO:0098791 CC 1 Golgi subcompartment 1 Q9Y587,Q9Y6B7 75 7.99e-04 50 2 2 1.000 0.040 HP:0002200 hp 1 Pseudobulbar signs 1 Q9Y587,Q9Y6B7 75 8.24e-04 182 2 2 1.000 0.011 GO:0031984 CC 1 organelle subcompartment 1 Q9Y587,Q9Y6B7 75 9.34e-04 54 2 2 1.000 0.037 HP:0001181 hp 1 Adducted thumb 1 Q9Y587,Q9Y6B7 75 9.69e-04 55 2 2 1.000 0.036 HP:0002307 hp 1 Drooling 1 Q9Y587,Q9Y6B7 75 1.00e-03 56 2 2 1.000 0.036 HP:0002515 hp 1 Waddling gait 1 Q9Y587,Q9Y6B7 75 1.12e-03 59 2 2 1.000 0.034 HP:0003781 hp 1 Excessive salivation 1 Q9Y587,Q9Y6B7 75 1.27e-03 63 2 2 1.000 0.032 HP:0000307 hp 1 Pointed chin 1 Q9Y587,Q9Y6B7 75 1.28e-03 227 2 2 1.000 0.009 GO:0044440 CC 1 endosomal part 1 Q9Y587,Q9Y6B7 75 1.71e-03 73 2 2 1.000 0.027 HP:0002352 hp 1 Leukoencephalopathy 1 Q9Y587,Q9Y6B7 75 1.71e-03 73 2 2 1.000 0.027 HP:0000448 hp 1 Prominent nose 1 Q9Y587,Q9Y6B7 75 1.71e-03 73 2 2 1.000 0.027 HP:0100755 hp 1 Abnormality of salivation 1 Q9Y587,Q9Y6B7 75 1.91e-03 77 2 2 1.000 0.026 HP:0002510 hp 1 Spastic tetraplegia 1 Q9Y587,Q9Y6B7 75 2.01e-03 79 2 2 1.000 0.025 HP:0000414 hp 1 Bulbous nose 1 Q9Y587,Q9Y6B7 75 2.06e-03 80 2 2 1.000 0.025 HP:0001258 hp 1 Spastic paraplegia 1 Q9Y587,Q9Y6B7 75 2.17e-03 82 2 2 1.000 0.024 HP:0010550 hp 1 Paraplegia 1 Q9Y587,Q9Y6B7 75 2.33e-03 85 2 2 1.000 0.024 HP:0006887 hp 1 Intellectual disability, progressive 1 Q9Y587,Q9Y6B7 75 2.44e-03 87 2 2 1.000 0.023 HP:0000275 hp 1 Narrow face 1 Q9Y587,Q9Y6B7 75 2.75e-03 332 2 2 1.000 0.006 GO:0000139 CC 1 Golgi membrane 1 Q9Y587,Q9Y6B7 75 2.89e-03 5 2 1 0.500 0.200 GO:0030023 MF 1 extracellular matrix constituent conferring elasticity 1 Q9Y6B7 75 3.10e-03 98 2 2 1.000 0.020 HP:0000274 hp 1 Small face 1 Q9Y587,Q9Y6B7 75 3.43e-03 103 2 2 1.000 0.019 HP:0002171 hp 1 Gliosis 1 Q9Y587,Q9Y6B7 75 3.46e-03 6 2 1 0.500 0.167 GO:0097493 MF 1 structural molecule activity conferring elasticity 1 Q9Y6B7 75 3.49e-03 104 2 2 1.000 0.019 HP:0000341 hp 1 Narrow forehead 1 Q9Y587,Q9Y6B7 75 3.63e-03 106 2 2 1.000 0.019 HP:0002061 hp 1 Lower limb spasticity 1 Q9Y587,Q9Y6B7 75 3.77e-03 108 2 2 1.000 0.019 HP:0002540 hp 1 Inability to walk 1 Q9Y587,Q9Y6B7 75 4.06e-03 112 2 2 1.000 0.018 HP:0010551 hp 1 Paraplegia/paraparesis 1 Q9Y587,Q9Y6B7 75 4.09e-03 477 2 2 1.000 0.004 TF:M01197_1 tf 1 Factor: Elf5; motif: WNAAGGAARTW; match class: 1 1 Q9Y587,Q9Y6B7 75 4.20e-03 114 2 2 1.000 0.018 HP:0003677 hp 1 Slow progression 1 Q9Y587,Q9Y6B7 75 4.43e-03 117 2 2 1.000 0.017 HP:0000154 hp 1 Wide mouth 1 Q9Y587,Q9Y6B7 75 4.82e-03 122 2 2 1.000 0.016 HP:0001319 hp 1 Neonatal hypotonia 1 Q9Y587,Q9Y6B7 75 5.14e-03 126 2 2 1.000 0.016 HP:0100705 hp 1 Abnormality of the glial cells 1 Q9Y587,Q9Y6B7 75 5.39e-03 129 2 2 1.000 0.016 HP:0000322 hp 1 Short philtrum 1 Q9Y587,Q9Y6B7 75 5.42e-03 466 2 2 1.000 0.004 GO:0005768 CC 1 endosome 1 Q9Y587,Q9Y6B7 75 5.80e-03 482 2 2 1.000 0.004 GO:0044431 CC 1 Golgi apparatus part 1 Q9Y587,Q9Y6B7 75 6.22e-03 499 2 2 1.000 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q9Y587,Q9Y6B7 75 7.69e-03 154 2 2 1.000 0.013 HP:0000301 hp 1 Abnormality of facial musculature 1 Q9Y587,Q9Y6B7 75 7.99e-03 157 2 2 1.000 0.013 HP:0000280 hp 1 Coarse facial features 1 Q9Y587,Q9Y6B7 75 8.09e-03 158 2 2 1.000 0.013 HP:0011119 hp 1 Abnormality of the nasal dorsum 1 Q9Y587,Q9Y6B7 75 8.83e-03 165 2 2 1.000 0.012 HP:0000303 hp 1 Mandibular prognathia 1 Q9Y587,Q9Y6B7 75 9.04e-03 167 2 2 1.000 0.012 HP:0001763 hp 1 Pes planus 1 Q9Y587,Q9Y6B7 75 9.48e-03 171 2 2 1.000 0.012 HP:0010864 hp 1 Intellectual disability, severe 1 Q9Y587,Q9Y6B7 75 9.48e-03 171 2 2 1.000 0.012 HP:0000436 hp 1 Abnormality of the nasal tip 1 Q9Y587,Q9Y6B7 75 1.18e-02 191 2 2 1.000 0.010 HP:0002815 hp 1 Abnormality of the knee 1 Q9Y587,Q9Y6B7 75 1.34e-02 203 2 2 1.000 0.010 HP:0002120 hp 1 Cerebral cortical atrophy 1 Q9Y587,Q9Y6B7 75 1.41e-02 750 2 2 1.000 0.003 GO:0005215 MF 1 transporter activity 1 Q9Y587,Q9Y6B7 75 1.43e-02 210 2 2 1.000 0.010 HP:0011337 hp 1 Abnormality of mouth size 1 Q9Y587,Q9Y6B7 75 1.46e-02 212 2 2 1.000 0.009 HP:0001762 hp 1 Talipes equinovarus 1 Q9Y587,Q9Y6B7 75 1.47e-02 213 2 2 1.000 0.009 HP:0003487 hp 1 Babinski sign 1 Q9Y587,Q9Y6B7 75 1.49e-02 214 2 2 1.000 0.009 HP:0011799 hp 1 Abnormality of facial soft tissue 1 Q9Y587,Q9Y6B7 75 1.66e-02 226 2 2 1.000 0.009 HP:0000306 hp 1 Abnormality of the chin 1 Q9Y587,Q9Y6B7 75 1.69e-02 522 2 2 1.000 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q9Y587,Q9Y6B7 75 1.70e-02 229 2 2 1.000 0.009 HP:0001272 hp 1 Cerebellar atrophy 1 Q9Y587,Q9Y6B7 75 1.79e-02 846 2 2 1.000 0.002 GO:0005794 CC 1 Golgi apparatus 1 Q9Y587,Q9Y6B7 75 1.79e-02 235 2 2 1.000 0.009 HP:0001172 hp 1 Abnormality of the thumb 1 Q9Y587,Q9Y6B7 75 1.87e-02 549 2 2 1.000 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9Y587,Q9Y6B7 75 1.88e-02 1022 2 2 1.000 0.002 TF:M04426_0 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 0 1 Q9Y587,Q9Y6B7 75 2.07e-02 910 2 2 1.000 0.002 GO:0097708 CC 1 intracellular vesicle 1 Q9Y587,Q9Y6B7 75 2.17e-02 931 2 2 1.000 0.002 GO:0031410 CC 1 cytoplasmic vesicle 1 Q9Y587,Q9Y6B7 75 2.20e-02 260 2 2 1.000 0.008 HP:0007256 hp 1 Abnormal pyramidal signs 1 Q9Y587,Q9Y6B7 75 2.21e-02 261 2 2 1.000 0.008 HP:0002079 hp 1 Hypoplasia of the corpus callosum 1 Q9Y587,Q9Y6B7 75 2.22e-02 1111 2 2 1.000 0.002 TF:M04282_0 tf 1 Factor: ARX; motif: NTAATYNAATTAN; match class: 0 1 Q9Y587,Q9Y6B7 75 2.23e-02 945 2 2 1.000 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 Q9Y587,Q9Y6B7 75 2.32e-02 267 2 2 1.000 0.007 HP:0001883 hp 1 Talipes 1 Q9Y587,Q9Y6B7 75 2.32e-02 267 2 2 1.000 0.007 HP:0000431 hp 1 Wide nasal bridge 1 Q9Y587,Q9Y6B7 75 2.33e-02 268 2 2 1.000 0.007 HP:0005656 hp 1 Positional foot deformity 1 Q9Y587,Q9Y6B7 75 2.40e-02 272 2 2 1.000 0.007 HP:0003577 hp 1 Congenital onset 1 Q9Y587,Q9Y6B7 75 2.47e-02 54 2 1 0.500 0.019 TF:M04345_1 tf 1 Factor: HOXB13; motif: CCAATAAAAN; match class: 1 1 Q9Y587 75 2.50e-02 1 2 1 0.500 1.000 OMIM:614067 omi 1 SPASTIC PARAPLEGIA 52, AUTOSOMAL RECESSIVE; SPG52;;CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 6, FORMERLY; CPSQ6, FORMERLY 1 Q9Y587 75 2.50e-02 1 2 1 0.500 1.000 OMIM:614066 omi 1 SPASTIC PARAPLEGIA 47, AUTOSOMAL RECESSIVE; SPG47;;CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 5, FORMERLY; CPSQ5, FORMERLY 1 Q9Y6B7 75 2.54e-02 44 2 1 0.500 0.023 GO:0005201 MF 1 extracellular matrix structural constituent 1 Q9Y6B7 75 2.60e-02 283 2 2 1.000 0.007 HP:0001332 hp 1 Dystonia 1 Q9Y587,Q9Y6B7 75 2.62e-02 284 2 2 1.000 0.007 HP:0010549 hp 1 Weakness due to upper motor neuron dysfunction 1 Q9Y587,Q9Y6B7 75 2.70e-02 288 2 2 1.000 0.007 HP:0000494 hp 1 Downslanted palpebral fissures 1 Q9Y587,Q9Y6B7 75 2.79e-02 1804 2 2 1.000 0.001 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q9Y587,Q9Y6B7 75 3.17e-02 312 2 2 1.000 0.006 HP:0100491 hp 1 Abnormality of lower limb joint 1 Q9Y587,Q9Y6B7 75 3.25e-02 71 2 1 0.500 0.014 TF:M05556_0 tf 1 Factor: ZNF784; motif: WSTATAAAGAAA; match class: 0 1 Q9Y587 75 3.34e-02 73 2 1 0.500 0.014 TF:M03996_1 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 1 1 Q9Y6B7 75 3.37e-02 322 2 2 1.000 0.006 HP:0001260 hp 1 Dysarthria 1 Q9Y587,Q9Y6B7 75 3.46e-02 313 2 2 1.000 0.006 MI:hsa-miR-26a-2* mi 1 MI:hsa-miR-26a-2* 1 Q9Y587,Q9Y6B7 75 3.49e-02 190 2 1 0.500 0.005 HPA:040020_03 hpa 1 soft tissue 2; chondrocytes[Uncertain,High] 1 Q9Y6B7 75 3.50e-02 328 2 2 1.000 0.006 HP:0002119 hp 1 Ventriculomegaly 1 Q9Y587,Q9Y6B7 75 3.52e-02 329 2 2 1.000 0.006 HP:0000288 hp 1 Abnormality of the philtrum 1 Q9Y587,Q9Y6B7 75 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q9Y587,Q9Y6B7 75 3.95e-02 2146 2 2 1.000 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 Q9Y587,Q9Y6B7 75 3.96e-02 349 2 2 1.000 0.006 HP:0000218 hp 1 High palate 1 Q9Y587,Q9Y6B7 75 4.11e-02 90 2 1 0.500 0.011 TF:M06038_0 tf 1 Factor: TCF17; motif: NGKGGAAWAAKM; match class: 0 1 Q9Y587 75 4.33e-02 365 2 2 1.000 0.005 HP:0002059 hp 1 Cerebral atrophy 1 Q9Y587,Q9Y6B7 75 4.34e-02 95 2 1 0.500 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 Q9Y6B7 75 4.41e-02 368 2 2 1.000 0.005 HP:0007369 hp 1 Atrophy/Degeneration affecting the cerebrum 1 Q9Y587,Q9Y6B7 75 4.48e-02 2286 2 2 1.000 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q9Y587,Q9Y6B7 75 4.60e-02 376 2 2 1.000 0.005 HP:0012444 hp 1 Brain atrophy 1 Q9Y587,Q9Y6B7 75 4.60e-02 376 2 2 1.000 0.005 HP:0001322 hp 1 Brain very small 1 Q9Y587,Q9Y6B7 75 5.00e-02 4 2 2 1.000 0.500 CORUM:67 cor 1 AP4 adaptor complex 1 Q9Y587,Q9Y6B7 75 5.00e-02 1414 2 2 1.000 0.001 GO:0031090 CC 1 organelle membrane 1 Q9Y587,Q9Y6B7 75 5.00e-02 2 2 1 0.500 0.500 OMIM:603513 omi 1 Spastic Quadriplegic Cerebral Palsy 1 Q9Y587 75 5.00e-02 111 2 2 1.000 0.018 KEGG:04142 keg 1 Lysosome 1 Q9Y587,Q9Y6B7 75 5.00e-02 376 2 2 1.000 0.005 MI:mmu-miR-687 mi 1 MI:mmu-miR-687 1 Q9Y587,Q9Y6B7 75 5.00e-02 1666 2 2 1.000 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q9Y587,Q9Y6B7 75 5.00e-02 56 2 1 0.500 0.018 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 Q9Y6B7 75 5.00e-02 392 2 2 1.000 0.005 HP:0003679 hp 1 Pace of progression 1 Q9Y587,Q9Y6B7 76 8.48e-03 49 2 1 0.500 0.020 GO:0031463 CC 1 Cul3-RING ubiquitin ligase complex 1 Q9H0H3 76 9.69e-03 56 2 1 0.500 0.018 GO:0006446 BP 1 regulation of translational initiation 1 Q9H0H3 76 1.78e-02 1440 2 2 1.000 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9H0H3,Q96A84 76 1.96e-02 421 2 2 1.000 0.005 TF:M00143_0 tf 1 Factor: Pax-5; motif: BCNNNRNGCANBGNTGNRTAGCSGCHNB; match class: 0 1 Q9H0H3,Q96A84 76 2.36e-02 137 2 1 0.500 0.007 GO:0031461 CC 1 cullin-RING ubiquitin ligase complex 1 Q9H0H3 76 2.82e-02 164 2 1 0.500 0.006 GO:0006413 BP 1 translational initiation 1 Q9H0H3 76 3.18e-02 185 2 1 0.500 0.005 GO:0042787 BP 1 protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q9H0H3 76 3.54e-02 206 2 1 0.500 0.005 GO:0006417 BP 1 regulation of translation 1 Q9H0H3 76 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q9H0H3,Q96A84 76 3.88e-02 226 2 1 0.500 0.004 GO:0000151 CC 1 ubiquitin ligase complex 1 Q9H0H3 76 3.93e-02 229 2 1 0.500 0.004 GO:0034248 BP 1 regulation of cellular amide metabolic process 1 Q9H0H3 76 4.51e-02 16 2 1 0.500 0.062 TF:M04037_0 tf 1 Factor: PKNOX2; motif: TGACAGGTGTCA; match class: 0 1 Q9H0H3 76 4.51e-02 16 2 1 0.500 0.062 TF:M04036_0 tf 1 Factor: PKNOX1; motif: TGACAGSTGTCA; match class: 0 1 Q9H0H3 76 4.55e-02 258 2 1 0.500 0.004 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 Q96A84 76 5.00e-02 672 2 2 1.000 0.003 TF:M07207_0 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 0 1 Q9H0H3,Q96A84 77 6.26e-03 2 3 1 0.333 0.500 GO:0046167 BP 1 glycerol-3-phosphate biosynthetic process 1 Q14410 77 6.26e-03 2 3 1 0.333 0.500 GO:0004370 MF 1 glycerol kinase activity 1 Q14410 77 6.26e-03 2 3 1 0.333 0.500 GO:2000349 BP 1 negative regulation of CD40 signaling pathway 1 Q13291 77 9.39e-03 3 3 1 0.333 0.333 GO:0006072 BP 1 glycerol-3-phosphate metabolic process 1 Q14410 77 9.39e-03 3 3 1 0.333 0.333 GO:2000348 BP 1 regulation of CD40 signaling pathway 1 Q13291 77 9.39e-03 3 3 1 0.333 0.333 GO:0002277 BP 1 myeloid dendritic cell activation involved in immune response 1 Q13291 77 1.25e-02 4 3 1 0.333 0.250 GO:0023035 BP 1 CD40 signaling pathway 1 Q13291 77 1.25e-02 4 3 1 0.333 0.250 GO:0052646 BP 1 alditol phosphate metabolic process 1 Q14410 77 1.88e-02 6 3 1 0.333 0.167 GO:0032695 BP 1 negative regulation of interleukin-12 production 1 Q13291 77 2.50e-02 8 3 1 0.333 0.125 GO:0001773 BP 1 myeloid dendritic cell activation 1 Q13291 77 2.50e-02 8 3 1 0.333 0.125 GO:0006071 BP 1 glycerol metabolic process 1 Q14410 77 2.68e-02 3233 3 3 1.000 0.001 HPA:041010_02 hpa 1 spleen; cells in red pulp[Uncertain,Medium] 1 Q13291,O60281,Q14410 77 2.81e-02 9 3 1 0.333 0.111 GO:0019400 BP 1 alditol metabolic process 1 Q14410 77 5.00e-02 1 3 1 0.333 1.000 TF:M05420_0 tf 1 Factor: ZNF339; motif: KACGGCCGGTACM; match class: 0 1 O60281 77 5.00e-02 16 3 1 0.333 0.062 GO:0032715 BP 1 negative regulation of interleukin-6 production 1 Q13291 77 5.00e-02 356 3 2 0.667 0.006 MI:hsa-miR-616* mi 1 MI:hsa-miR-616* 1 Q13291,O60281 77 5.00e-02 1 3 1 0.333 1.000 TF:M06488_1 tf 1 Factor: ZNF595; motif: NGGGAGGGMWTC; match class: 1 1 Q13291 77 5.00e-02 48 3 1 0.333 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 Q14410 77 5.00e-02 64 3 1 0.333 0.016 REAC:75109 rea 1 Triglyceride Biosynthesis 1 Q14410 78 1.08e-04 23 3 2 0.667 0.087 GO:0000154 BP 1 rRNA modification 1 Q9NXG2,Q9BRP7 78 8.12e-04 211 3 2 0.667 0.009 TF:M05594_0 tf 1 Factor: Staf; motif: GTTTACAAACG; match class: 0 1 Q05682,Q9BRP7 78 2.22e-03 103 3 2 0.667 0.019 GO:0009451 BP 1 RNA modification 1 Q9NXG2,Q9BRP7 78 2.46e-03 1 3 1 0.333 1.000 GO:0070042 MF 1 rRNA (uridine-N3-)-methyltransferase activity 1 Q9BRP7 78 4.66e-03 149 3 2 0.667 0.013 GO:0006399 BP 1 tRNA metabolic process 1 Q9NXG2,Q9BRP7 78 4.71e-03 20 3 1 0.333 0.050 TF:M04026_0 tf 1 Factor: SMAD3; motif: YGTCTAGACA; match class: 0 1 Q9BRP7 78 4.82e-03 2151 3 3 1.000 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 5.57e-03 2257 3 3 1.000 0.001 TF:M05445_1 tf 1 Factor: GATA-5; motif: TTAMCAR; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 5.57e-03 2257 3 3 1.000 0.001 TF:M05725_1 tf 1 Factor: GATA-2; motif: KTAMCAR; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 5.63e-03 493 3 2 0.667 0.004 MI:mmu-miR-350 mi 1 MI:mmu-miR-350 1 Q9NXG2,Q9BRP7 78 7.37e-03 3 3 1 0.333 0.333 GO:0016436 MF 1 rRNA (uridine) methyltransferase activity 1 Q9BRP7 78 1.06e-02 45 3 1 0.333 0.022 TF:M06367_0 tf 1 Factor: ZNF530; motif: KGGGGAAAAAKA; match class: 0 1 Q9BRP7 78 1.08e-02 2816 3 3 1.000 0.001 TF:M07315_1 tf 1 Factor: C/EBPbeta; motif: NNTTKCNNMAN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 1.10e-02 229 3 2 0.667 0.009 GO:0006364 BP 1 rRNA processing 1 Q9NXG2,Q9BRP7 78 1.13e-02 232 3 2 0.667 0.009 GO:0016072 BP 1 rRNA metabolic process 1 Q9NXG2,Q9BRP7 78 1.16e-02 2880 3 3 1.000 0.001 TF:M00088_1 tf 1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 1.23e-02 5 3 1 0.333 0.200 GO:0004826 MF 1 phenylalanine-tRNA ligase activity 1 Q9BRP7 78 1.23e-02 5 3 1 0.333 0.200 GO:0006432 BP 1 phenylalanyl-tRNA aminoacylation 1 Q9BRP7 78 1.27e-02 2967 3 3 1.000 0.001 TF:M00116_1 tf 1 Factor: C/EBPalpha; motif: NNATTRCNNAANNN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 1.50e-02 64 3 1 0.333 0.016 TF:M00237_0 tf 1 Factor: AhR:Arnt; motif: GRGKATYGCGTGMCWNSCC; match class: 0 1 Q9BRP7 78 1.52e-02 3152 3 3 1.000 0.001 TF:M04379_1 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 1.55e-02 939 3 2 0.667 0.002 TF:M03843_1 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 1 1 Q05682,Q9BRP7 78 1.59e-02 68 3 1 0.333 0.015 TF:M06636_0 tf 1 Factor: ZNF599; motif: NRGAGTGTGGGC; match class: 0 1 Q9NXG2 78 1.60e-02 3206 3 3 1.000 0.001 TF:M03997_1 tf 1 Factor: GATA3; motif: NGATAANN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 1.61e-02 278 3 2 0.667 0.007 GO:0042254 BP 1 ribosome biogenesis 1 Q9NXG2,Q9BRP7 78 1.71e-02 73 3 1 0.333 0.014 TF:M05974_0 tf 1 Factor: ZNF701; motif: KGGGAATGCAGM; match class: 0 1 Q9BRP7 78 1.83e-02 1021 3 2 0.667 0.002 TF:M03566_0 tf 1 Factor: SNA; motif: GCCACCTGNCNGYN; match class: 0 1 Q9NXG2,Q9BRP7 78 1.85e-02 3370 3 3 1.000 0.001 TF:M00192_0 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 1.92e-02 82 3 1 0.333 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 Q9BRP7 78 1.96e-02 8 3 1 0.333 0.125 GO:0070475 BP 1 rRNA base methylation 1 Q9BRP7 78 2.12e-02 1102 3 2 0.667 0.002 TF:M00471_1 tf 1 Factor: TBP; motif: TATAAATW; match class: 1 1 Q05682,Q9BRP7 78 2.45e-02 10 3 1 0.333 0.100 GO:0005523 MF 1 tropomyosin binding 1 Q05682 78 2.46e-02 1191 3 2 0.667 0.002 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q9NXG2,Q9BRP7 78 2.49e-02 1197 3 2 0.667 0.002 TF:M04405_0 tf 1 Factor: MSX1; motif: NCAATTAN; match class: 0 1 Q9NXG2,Q05682 78 2.52e-02 348 3 2 0.667 0.006 GO:0034470 BP 1 ncRNA processing 1 Q9NXG2,Q9BRP7 78 2.62e-02 3782 3 3 1.000 0.001 TF:M07300_1 tf 1 Factor: NF-1C; motif: TTGGCNN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 2.76e-02 118 3 1 0.333 0.008 TF:M00054_1 tf 1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 1 Q9NXG2 78 2.80e-02 120 3 1 0.333 0.008 TF:M05473_0 tf 1 Factor: DRRS; motif: NTTTTCNATTGA; match class: 0 1 Q05682 78 2.82e-02 1277 3 2 0.667 0.002 TF:M01820_0 tf 1 Factor: CREM; motif: TGACGTCASYN; match class: 0 1 Q9NXG2,Q05682 78 3.01e-02 1322 3 2 0.667 0.002 TF:M00113_0 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 0 1 Q9NXG2,Q05682 78 3.03e-02 130 3 1 0.333 0.008 TF:M07210_1 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 1 1 Q9BRP7 78 3.09e-02 3996 3 3 1.000 0.001 TF:M00917_0 tf 1 Factor: CREB; motif: CNNTGACGTMA; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 3.13e-02 4010 3 3 1.000 0.001 TF:M03544_0 tf 1 Factor: CREB1; motif: NNNNACGTCANN; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 3.19e-02 13 3 1 0.333 0.077 GO:0008649 MF 1 rRNA methyltransferase activity 1 Q9BRP7 78 3.22e-02 394 3 2 0.667 0.005 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 Q9NXG2,Q9BRP7 78 3.25e-02 4063 3 3 1.000 0.001 TF:M02269_0 tf 1 Factor: FEV; motif: CAGGAART; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 3.27e-02 4071 3 3 1.000 0.001 TF:M00109_1 tf 1 Factor: C/EBPbeta; motif: RNRTKDNGMAAKNN; match class: 1 1 Q9NXG2,Q05682,Q9BRP7 78 3.38e-02 145 3 1 0.333 0.007 TF:M02377_1 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 1 1 Q9BRP7 78 3.38e-02 145 3 1 0.333 0.007 TF:M00978_1 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 1 1 Q9BRP7 78 3.38e-02 4117 3 3 1.000 0.001 TF:M03921_0 tf 1 Factor: SP3; motif: NCCACGCCCMC; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 3.64e-02 1460 3 2 0.667 0.001 TF:M00528_0 tf 1 Factor: PPAR; motif: WASNRGGNCAAAGGTCA; match class: 0 1 Q9NXG2,Q05682 78 3.66e-02 157 3 1 0.333 0.006 TF:M04404_0 tf 1 Factor: MSX1; motif: NCAATTAAANNSCAATTA; match class: 0 1 Q05682 78 3.68e-02 15 3 1 0.333 0.067 GO:0031167 BP 1 rRNA methylation 1 Q9BRP7 78 4.01e-02 4357 3 3 1.000 0.001 TF:M02028_0 tf 1 Factor: Pbx1; motif: ATCAATCAN; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 4.03e-02 147 3 1 0.333 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q05682 78 4.05e-02 1543 3 2 0.667 0.001 TF:M04074_0 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 0 1 Q9NXG2,Q05682 78 4.07e-02 4378 3 3 1.000 0.001 TF:M07285_0 tf 1 Factor: ESE-1; motif: NNYTTCCTG; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 4.25e-02 183 3 1 0.333 0.005 TF:M06623_0 tf 1 Factor: ZNF778; motif: NTMAGWTTGCGC; match class: 0 1 Q9NXG2 78 4.26e-02 4447 3 3 1.000 0.001 TF:M07304_0 tf 1 Factor: Pbx; motif: NTGATTGANN; match class: 0 1 Q9NXG2,Q05682,Q9BRP7 78 4.27e-02 184 3 1 0.333 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 Q9NXG2 78 4.50e-02 194 3 1 0.333 0.005 TF:M06135_0 tf 1 Factor: ZNF28; motif: GCKAAAGGAWA; match class: 0 1 Q9BRP7 78 4.50e-02 194 3 1 0.333 0.005 TF:M06860_0 tf 1 Factor: ZNF549; motif: NCTTTTWTGGGA; match class: 0 1 Q05682 78 4.92e-02 1708 3 2 0.667 0.001 TF:M00203_0 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 0 1 Q05682,Q9BRP7 78 5.00e-02 24 3 1 0.333 0.042 REAC:445355 rea 1 Smooth Muscle Contraction 1 Q05682 78 5.00e-02 492 3 2 0.667 0.004 GO:0034660 BP 1 ncRNA metabolic process 1 Q9NXG2,Q9BRP7 78 5.00e-02 85 3 1 0.333 0.012 KEGG:04270 keg 1 Vascular smooth muscle contraction 1 Q05682 79 8.09e-03 1 4 1 0.250 1.000 TF:M05893_1 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 1 1 P08235 79 9.44e-03 457 4 2 0.500 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 Q6SZW1,Q8N4J0 79 1.74e-02 626 4 2 0.500 0.003 MI:mmu-miR-291b-3p mi 1 MI:mmu-miR-291b-3p 1 Q6SZW1,Q8N4J0 79 2.50e-02 1 4 1 0.250 1.000 HP:0040085 hp 1 Abnormal circulating aldosterone 1 P08235 79 2.50e-02 1 4 1 0.250 1.000 HP:0002924 hp 1 Decreased circulating aldosterone level 1 P08235 79 4.04e-02 5 4 1 0.250 0.200 TF:M04342_1 tf 1 Factor: HOXA13; motif: NCTCGTAAAAN; match class: 1 1 Q96B70 79 4.04e-02 5 4 1 0.250 0.200 TF:M04346_1 tf 1 Factor: HOXB13; motif: NCTCGTAAAAN; match class: 1 1 Q96B70 79 4.04e-02 5 4 1 0.250 0.200 TF:M04358_1 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 1 1 Q96B70 79 4.52e-02 2606 4 4 1.000 0.002 TF:M04149_0 tf 1 Factor: TFAP2B; motif: NGCCCNNRGGCA; match class: 0 1 Q6SZW1,P08235,Q8N4J0,Q96B70 79 5.00e-02 6 4 1 0.250 0.167 REAC:70921 rea 1 Histidine catabolism 1 Q8N4J0 79 5.00e-02 1 4 1 0.250 1.000 OMIM:605115 omi 1 HYPERTENSION, EARLY-ONSET, AUTOSOMAL DOMINANT, WITH SEVERE EXACERBATIONIN PREGNANCY 1 P08235 79 5.00e-02 18 4 1 0.250 0.056 KEGG:00340 keg 1 Histidine metabolism 1 Q8N4J0 79 5.00e-02 1 4 1 0.250 1.000 OMIM:177735 omi 1 PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT; PHA1A;;PHA I, AUTOSOMAL DOMINANT 1 P08235 79 5.00e-02 2 4 1 0.250 0.500 HP:0008071 hp 1 Maternal hypertension 1 P08235 79 5.00e-02 3 4 1 0.250 0.333 CORUM:786 cor 1 MR-UBC9-SRC1 complex 1 P08235 79 5.00e-02 2673 4 4 1.000 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 Q6SZW1,P08235,Q8N4J0,Q96B70 79 5.00e-02 2673 4 4 1.000 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 Q6SZW1,P08235,Q8N4J0,Q96B70 79 5.00e-02 3 4 1 0.250 0.333 CORUM:3634 cor 1 NR3C2-UBC9-SRC-1 complex 1 P08235 79 5.00e-02 1 4 1 0.250 1.000 GO:0030735 MF 1 carnosine N-methyltransferase activity 1 Q8N4J0 80 1.41e-03 6 3 1 0.333 0.167 TF:M06585_0 tf 1 Factor: ZNF479; motif: NGGTACTGMCKT; match class: 0 1 Q9UKT8 80 2.12e-03 9 3 1 0.333 0.111 TF:M05778_0 tf 1 Factor: ZNF311; motif: NRGTAWGAAAGA; match class: 0 1 Q5MJ09 80 4.96e-03 525 3 2 0.667 0.004 TF:M07357_0 tf 1 Factor: HNF-6; motif: RNNWAAATCAATAAN; match class: 0 1 Q5MJ09,Q96EF6 80 6.12e-03 26 3 1 0.333 0.038 TF:M06989_0 tf 1 Factor: ZNF236; motif: MGTAATATTRA; match class: 0 1 Q9UKT8 80 7.05e-03 30 3 1 0.333 0.033 TF:M06724_0 tf 1 Factor: ZNF331; motif: NTGTTTGGTCGC; match class: 0 1 Q96EF6 80 7.76e-03 2521 3 3 1.000 0.001 TF:M05883_0 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 8.80e-03 703 3 2 0.667 0.003 TF:M01854_1 tf 1 Factor: AML2; motif: CCRCACCAYDN; match class: 1 1 Q9UKT8,Q5MJ09 80 9.97e-03 2740 3 3 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 1.01e-02 272 3 2 0.667 0.007 REAC:983168 rea 1 Antigen processing: Ubiquitination & Proteasome degradation 1 Q9UKT8,Q96EF6 80 1.31e-02 56 3 1 0.333 0.018 TF:M03975_1 tf 1 Factor: ERG; motif: ACCGGAARTN; match class: 1 1 Q9UKT8 80 1.32e-02 3009 3 3 1.000 0.001 TF:M01590_1 tf 1 Factor: SMAD1; motif: NANRACAAARGN; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 1.41e-02 322 3 2 0.667 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q9UKT8,Q96EF6 80 1.55e-02 940 3 2 0.667 0.002 TF:M06475_0 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 0 1 Q9UKT8,Q5MJ09 80 1.59e-02 68 3 1 0.333 0.015 TF:M06425_0 tf 1 Factor: ZNF227; motif: NSAAGGGTGARA; match class: 0 1 Q9UKT8 80 1.66e-02 972 3 2 0.667 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q9UKT8,Q96EF6 80 1.73e-02 74 3 1 0.333 0.014 TF:M03979_1 tf 1 Factor: ETV1; motif: ACCGGAAGTN; match class: 1 1 Q9UKT8 80 1.78e-02 76 3 1 0.333 0.013 TF:M04087_1 tf 1 Factor: POU4F3; motif: NTGMATWATTAATGNN; match class: 1 1 Q5MJ09 80 1.83e-02 78 3 1 0.333 0.013 TF:M02073_1 tf 1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 1 Q9UKT8 80 2.01e-02 86 3 1 0.333 0.012 TF:M03977_1 tf 1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 1 Q9UKT8 80 2.55e-02 109 3 1 0.333 0.009 TF:M03934_0 tf 1 Factor: ZBTB18; motif: NATCCAGATGTKN; match class: 0 1 Q5MJ09 80 2.72e-02 3829 3 3 1.000 0.001 TF:M01709_1 tf 1 Factor: MAFA; motif: TCAGCAN; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 2.81e-02 1276 3 2 0.667 0.002 TF:M00136_0 tf 1 Factor: Oct-1; motif: NNGAATATKCANNNN; match class: 0 1 Q9UKT8,Q5MJ09 80 2.83e-02 3879 3 3 1.000 0.001 TF:M03873_0 tf 1 Factor: HOXA10; motif: ANTTTATG; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 2.89e-02 124 3 1 0.333 0.008 TF:M00421_0 tf 1 Factor: MEIS1B:HOXA9; motif: TGACASTTTWAYRR; match class: 0 1 Q5MJ09 80 3.10e-02 133 3 1 0.333 0.008 TF:M06159_0 tf 1 Factor: ZNF83; motif: NTGGCAAARARM; match class: 0 1 Q9UKT8 80 3.15e-02 135 3 1 0.333 0.007 TF:M02064_1 tf 1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 1 1 Q9UKT8 80 3.25e-02 4064 3 3 1.000 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 3.49e-02 150 3 1 0.333 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 Q5MJ09 80 3.62e-02 4212 3 3 1.000 0.001 TF:M04075_0 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 3.66e-02 157 3 1 0.333 0.006 TF:M04404_0 tf 1 Factor: MSX1; motif: NCAATTAAANNSCAATTA; match class: 0 1 Q5MJ09 80 3.71e-02 1474 3 2 0.667 0.001 TF:M01211_0 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 0 1 Q5MJ09,Q96EF6 80 3.75e-02 37 3 1 0.333 0.027 REAC:390471 rea 1 Association of TriC/CCT with target proteins during biosynthesis 1 Q9UKT8 80 3.80e-02 1493 3 2 0.667 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 Q9UKT8,Q5MJ09 80 3.84e-02 1500 3 2 0.667 0.001 TF:M01108_1 tf 1 Factor: HOXA7; motif: YCAATCT; match class: 1 1 Q9UKT8,Q5MJ09 80 3.86e-02 1504 3 2 0.667 0.001 TF:M05313_0 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 0 1 Q9UKT8,Q5MJ09 80 3.93e-02 169 3 1 0.333 0.006 TF:M04085_1 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 1 1 Q5MJ09 80 3.94e-02 4332 3 3 1.000 0.001 TF:M04073_0 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 3.96e-02 1524 3 2 0.667 0.001 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q9UKT8,Q5MJ09 80 4.05e-02 174 3 1 0.333 0.006 TF:M06320_0 tf 1 Factor: ZNF791; motif: NGGTTATGAMGA; match class: 0 1 Q9UKT8 80 4.14e-02 178 3 1 0.333 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 Q96EF6 80 4.29e-02 4457 3 3 1.000 0.001 TF:M07282_0 tf 1 Factor: ER71; motif: CWTCCTGT; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 4.29e-02 4457 3 3 1.000 0.001 TF:M03844_0 tf 1 Factor: SAP-1a; motif: CWTCCKGT; match class: 0 1 Q9UKT8,Q5MJ09,Q96EF6 80 4.33e-02 1598 3 2 0.667 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 Q5MJ09,Q96EF6 80 4.44e-02 191 3 1 0.333 0.005 TF:M07217_0 tf 1 Factor: MAX; motif: RRGCACATGK; match class: 0 1 Q96EF6 80 4.46e-02 192 3 1 0.333 0.005 TF:M04012_1 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 1 1 Q96EF6 80 4.64e-02 200 3 1 0.333 0.005 TF:M01752_1 tf 1 Factor: ERG; motif: ACCGGAART; match class: 1 1 Q9UKT8 80 4.72e-02 4601 3 3 1.000 0.001 TF:M07268_1 tf 1 Factor: SOX4; motif: BCWTTGT; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q9UKT8,Q5MJ09,Q96EF6 80 4.91e-02 212 3 1 0.333 0.005 TF:M04042_1 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 1 1 Q5MJ09 80 5.00e-02 3 3 1 0.333 0.333 CORUM:390 cor 1 Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) 1 Q9UKT8 80 5.00e-02 614 3 2 0.667 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 Q9UKT8,Q96EF6 81 7.71e-04 1 2 1 0.500 1.000 GO:0034338 MF 1 short-chain carboxylesterase activity 1 Q9HAT2 81 7.71e-04 1 2 1 0.500 1.000 GO:0008126 MF 1 acetylesterase activity 1 Q9HAT2 81 7.71e-04 1 2 1 0.500 1.000 GO:0001681 MF 1 sialate O-acetylesterase activity 1 Q9HAT2 81 5.00e-02 398 2 2 1.000 0.005 MI:hsa-miR-302a* mi 1 MI:hsa-miR-302a* 1 Q9HAT2,Q5VSG8 81 5.00e-02 65 2 1 0.500 0.015 GO:0052689 MF 1 carboxylic ester hydrolase activity 1 Q9HAT2 81 5.00e-02 5 2 1 0.500 0.200 TF:M05479_1 tf 1 Factor: znf580; motif: NGGGCGGTGTS; match class: 1 1 Q5VSG8 81 5.00e-02 1 2 1 0.500 1.000 OMIM:613551 omi 1 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6; AIS6 1 Q9HAT2 82 2.86e-03 2 2 1 0.500 0.500 GO:0050220 MF 1 prostaglandin-E synthase activity 1 Q15185 82 4.97e-03 9 2 1 0.500 0.111 REAC:2162123 rea 1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1 Q15185 82 5.72e-03 4 2 1 0.500 0.250 GO:0070389 BP 1 chaperone cofactor-dependent protein refolding 1 Q15185 82 8.58e-03 6 2 1 0.500 0.167 GO:0019371 BP 1 cyclooxygenase pathway 1 Q15185 82 1.00e-02 7 2 1 0.500 0.143 GO:0003964 MF 1 RNA-directed DNA polymerase activity 1 Q15185 82 1.00e-02 7 2 1 0.500 0.143 GO:0003720 MF 1 telomerase activity 1 Q15185 82 1.21e-02 22 2 1 0.500 0.045 REAC:3371568 rea 1 Attenuation phase 1 Q15185 82 1.38e-02 25 2 1 0.500 0.040 REAC:3371511 rea 1 HSF1 activation 1 Q15185 82 1.61e-02 409 2 2 1.000 0.005 TF:M00731_1 tf 1 Factor: Osf2; motif: ACCACANM; match class: 1 1 Q15185,Q9H009 82 1.66e-02 30 2 1 0.500 0.033 REAC:3371571 rea 1 HSF1-dependent transactivation 1 Q15185 82 1.72e-02 12 2 1 0.500 0.083 GO:0046457 BP 1 prostanoid biosynthetic process 1 Q15185 82 1.72e-02 12 2 1 0.500 0.083 GO:0001516 BP 1 prostaglandin biosynthetic process 1 Q15185 82 1.77e-02 32 2 1 0.500 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 Q15185 82 2.29e-02 16 2 1 0.500 0.062 GO:0006693 BP 1 prostaglandin metabolic process 1 Q15185 82 2.29e-02 16 2 1 0.500 0.062 GO:0006692 BP 1 prostanoid metabolic process 1 Q15185 82 2.57e-02 18 2 1 0.500 0.056 GO:0042026 BP 1 protein refolding 1 Q15185 82 2.72e-02 19 2 1 0.500 0.053 GO:1901570 BP 1 fatty acid derivative biosynthetic process 1 Q15185 82 2.72e-02 19 2 1 0.500 0.053 GO:0046456 BP 1 icosanoid biosynthetic process 1 Q15185 82 2.87e-02 546 2 2 1.000 0.004 TF:M07306_0 tf 1 Factor: RORalpha; motif: NNWNNAWNTRGGTCAG; match class: 0 1 Q15185,Q9H009 82 3.00e-02 21 2 1 0.500 0.048 GO:0005697 CC 1 telomerase holoenzyme complex 1 Q15185 82 3.72e-02 26 2 1 0.500 0.038 GO:0034061 MF 1 DNA polymerase activity 1 Q15185 82 4.00e-02 28 2 1 0.500 0.036 GO:0006636 BP 1 unsaturated fatty acid biosynthetic process 1 Q15185 82 4.18e-02 17 2 1 0.500 0.059 TF:M06785_0 tf 1 Factor: ZNF629; motif: NGWTAMGAAACC; match class: 0 1 Q15185 82 4.29e-02 30 2 1 0.500 0.033 GO:0019369 BP 1 arachidonic acid metabolic process 1 Q15185 82 4.87e-02 276 2 1 0.500 0.004 MI:hsa-miR-96* mi 1 MI:hsa-miR-96* 1 Q15185 82 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q15185 82 5.00e-02 35 2 1 0.500 0.029 GO:0061077 BP 1 chaperone-mediated protein folding 1 Q15185 82 5.00e-02 36 2 1 0.500 0.028 KEGG:00590 keg 1 Arachidonic acid metabolism 1 Q15185 82 5.00e-02 720 2 2 1.000 0.003 TF:M02268_0 tf 1 Factor: INSM1; motif: TGYCAGGGGGCR; match class: 0 1 Q15185,Q9H009 82 5.00e-02 3 2 1 0.500 0.333 CORUM:999 cor 1 p23 protein complex 1 Q15185 83 2.72e-03 2 9 1 0.111 0.500 GO:0070853 MF 1 myosin VI binding 1 Q8IWU2 83 3.72e-03 420 9 3 0.333 0.007 MI:hsa-miR-604 mi 1 MI:hsa-miR-604 1 Q8N350,Q8IWU2,Q9H792 83 5.44e-03 4 9 1 0.111 0.250 GO:1901386 BP 1 negative regulation of voltage-gated calcium channel activity 1 Q8N350 83 5.68e-03 413 9 3 0.333 0.007 GO:0097458 CC 1 neuron part 1 Q9Y6H5,Q8N350,Q9ULJ8 83 8.15e-03 6 9 1 0.111 0.167 GO:0045955 BP 1 negative regulation of calcium ion-dependent exocytosis 1 Q8N350 83 9.51e-03 7 9 1 0.111 0.143 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 P36873 83 9.51e-03 7 9 1 0.111 0.143 GO:1903306 BP 1 negative regulation of regulated secretory pathway 1 Q8N350 83 1.09e-02 8 9 1 0.111 0.125 GO:0070688 CC 1 MLL5-L complex 1 P36873 83 1.27e-02 170 9 2 0.222 0.012 GO:0044456 CC 1 synapse part 1 Q9Y6H5,Q9ULJ8 83 1.31e-02 173 9 2 0.222 0.012 GO:0036477 CC 1 somatodendritic compartment 1 Q9Y6H5,Q9ULJ8 83 1.40e-02 179 9 2 0.222 0.011 GO:0046777 BP 1 protein autophosphorylation 1 Q8IWU2,Q9H792 83 1.63e-02 12 9 1 0.111 0.083 GO:1901385 BP 1 regulation of voltage-gated calcium channel activity 1 Q8N350 83 1.63e-02 12 9 1 0.111 0.083 GO:0090083 BP 1 regulation of inclusion body assembly 1 Q9Y6H5 83 1.89e-02 272 9 2 0.222 0.007 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 Q9GZN8,Q96PV6 83 1.96e-02 213 9 2 0.222 0.009 GO:0045202 CC 1 synapse 1 Q9Y6H5,Q9ULJ8 83 2.03e-02 15 9 1 0.111 0.067 GO:0004864 MF 1 protein phosphatase inhibitor activity 1 Q8IWU2 83 2.03e-02 15 9 1 0.111 0.067 GO:0045920 BP 1 negative regulation of exocytosis 1 Q8N350 83 2.03e-02 15 9 1 0.111 0.067 GO:0043153 BP 1 entrainment of circadian clock by photoperiod 1 P36873 83 2.03e-02 15 9 1 0.111 0.067 GO:0042417 BP 1 dopamine metabolic process 1 Q9Y6H5 83 2.03e-02 15 9 1 0.111 0.067 GO:1901020 BP 1 negative regulation of calcium ion transmembrane transporter activity 1 Q8N350 83 2.03e-02 15 9 1 0.111 0.067 GO:1903170 BP 1 negative regulation of calcium ion transmembrane transport 1 Q8N350 83 2.03e-02 15 9 1 0.111 0.067 GO:0070841 BP 1 inclusion body assembly 1 Q9Y6H5 83 2.06e-02 219 9 2 0.222 0.009 GO:0016311 BP 1 dephosphorylation 1 Q9H175,P36873 83 2.15e-02 224 9 2 0.222 0.009 GO:0099503 CC 1 secretory vesicle 1 Q9Y6H5,Q8N350 83 2.17e-02 16 9 1 0.111 0.062 GO:0009648 BP 1 photoperiodism 1 P36873 83 2.17e-02 16 9 1 0.111 0.062 GO:2001258 BP 1 negative regulation of cation channel activity 1 Q8N350 83 2.30e-02 17 9 1 0.111 0.059 GO:0019212 MF 1 phosphatase inhibitor activity 1 Q8IWU2 83 2.35e-02 305 9 2 0.222 0.007 MI:mmu-miR-718 mi 1 MI:mmu-miR-718 1 Q8N350,Q8IWU2 83 2.44e-02 18 9 1 0.111 0.056 GO:0009649 BP 1 entrainment of circadian clock 1 P36873 83 2.46e-02 313 9 2 0.222 0.006 MI:hsa-miR-668 mi 1 MI:hsa-miR-668 1 Q9GZN8,Q9H792 83 2.55e-02 319 9 2 0.222 0.006 MI:hsa-miR-106b* mi 1 MI:hsa-miR-106b* 1 Q9ULJ8,Q8IWU2 83 2.70e-02 329 9 2 0.222 0.006 MI:hsa-miR-363* mi 1 MI:hsa-miR-363* 1 Q9Y6H5,Q8IWU2 83 2.70e-02 20 9 1 0.111 0.050 GO:0001881 BP 1 receptor recycling 1 Q8IWU2 83 2.84e-02 21 9 1 0.111 0.048 GO:0006584 BP 1 catecholamine metabolic process 1 Q9Y6H5 83 2.84e-02 21 9 1 0.111 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 Q8N350 83 2.84e-02 21 9 1 0.111 0.048 GO:0009712 BP 1 catechol-containing compound metabolic process 1 Q9Y6H5 83 2.97e-02 346 9 2 0.222 0.006 MI:hsa-miR-624* mi 1 MI:hsa-miR-624* 1 Q9Y6H5,Q8N350 83 2.97e-02 22 9 1 0.111 0.045 GO:0046928 BP 1 regulation of neurotransmitter secretion 1 Q9Y6H5 83 3.08e-02 270 9 2 0.222 0.007 GO:1903530 BP 1 regulation of secretion by cell 1 Q9Y6H5,Q8N350 83 3.11e-02 23 9 1 0.111 0.043 GO:0042734 CC 1 presynaptic membrane 1 Q9Y6H5 83 3.24e-02 363 9 2 0.222 0.006 MI:hsa-miR-504 mi 1 MI:hsa-miR-504 1 Q8N350,Q9GZN8 83 3.39e-02 372 9 2 0.222 0.005 MI:mmu-miR-704 mi 1 MI:mmu-miR-704 1 Q9ULJ8,P36873 83 3.41e-02 285 9 2 0.222 0.007 GO:0051046 BP 1 regulation of secretion 1 Q9Y6H5,Q8N350 83 3.43e-02 286 9 2 0.222 0.007 GO:0043005 CC 1 neuron projection 1 Q8N350,Q9ULJ8 83 3.50e-02 1635 9 4 0.444 0.002 HPA:039020_02 hpa 1 soft tissue 1; chondrocytes[Uncertain,Medium] 1 Q9Y6H5,Q9H175,Q9H792,P36873 83 3.51e-02 26 9 1 0.111 0.038 GO:0032456 BP 1 endocytic recycling 1 Q8IWU2 83 3.53e-02 380 9 2 0.222 0.005 MI:hsa-miR-662 mi 1 MI:hsa-miR-662 1 Q9Y6H5,Q8N350 83 3.56e-02 382 9 2 0.222 0.005 MI:mmu-miR-676 mi 1 MI:mmu-miR-676 1 Q9Y6H5,Q8N350 83 3.56e-02 382 9 2 0.222 0.005 MI:hsa-miR-637 mi 1 MI:hsa-miR-637 1 Q8IWU2,Q96PV6 83 3.65e-02 387 9 2 0.222 0.005 MI:hsa-miR-933 mi 1 MI:hsa-miR-933 1 Q9GZN8,Q8IWU2 83 3.69e-02 389 9 2 0.222 0.005 MI:hsa-miR-92a-2* mi 1 MI:hsa-miR-92a-2* 1 Q9GZN8,Q9ULJ8 83 3.74e-02 392 9 2 0.222 0.005 MI:hsa-miR-652 mi 1 MI:hsa-miR-652 1 Q9GZN8,Q8IWU2 83 3.78e-02 28 9 1 0.111 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 Q8N350 83 3.81e-02 396 9 2 0.222 0.005 MI:mmu-miR-688 mi 1 MI:mmu-miR-688 1 Q96PV6,Q9H792 83 3.83e-02 397 9 2 0.222 0.005 MI:hsa-miR-939 mi 1 MI:hsa-miR-939 1 Q8IWU2,Q9H792 83 3.86e-02 399 9 2 0.222 0.005 MI:hsa-miR-612 mi 1 MI:hsa-miR-612 1 Q9GZN8,Q8IWU2 83 3.89e-02 306 9 2 0.222 0.007 GO:0015629 CC 1 actin cytoskeleton 1 Q9ULJ8,Q9H792 83 3.91e-02 29 9 1 0.111 0.034 GO:0019208 MF 1 phosphatase regulator activity 1 Q8IWU2 83 3.95e-02 404 9 2 0.222 0.005 MI:hsa-miR-210 mi 1 MI:hsa-miR-210 1 Q8IWU2,P36873 83 4.04e-02 30 9 1 0.111 0.033 GO:1904063 BP 1 negative regulation of cation transmembrane transport 1 Q8N350 83 4.04e-02 30 9 1 0.111 0.033 GO:0072512 BP 1 trivalent inorganic cation transport 1 Q8IWU2 83 4.04e-02 30 9 1 0.111 0.033 GO:0015682 BP 1 ferric iron transport 1 Q8IWU2 83 4.04e-02 30 9 1 0.111 0.033 GO:0033572 BP 1 transferrin transport 1 Q8IWU2 83 4.06e-02 410 9 2 0.222 0.005 MI:hsa-miR-610 mi 1 MI:hsa-miR-610 1 Q9Y6H5,Q9ULJ8 83 4.08e-02 411 9 2 0.222 0.005 MI:hsa-miR-92a mi 1 MI:hsa-miR-92a 1 Q9GZN8,Q9H792 83 4.30e-02 423 9 2 0.222 0.005 MI:hsa-miR-342-5p mi 1 MI:hsa-miR-342-5p 1 Q9ULJ8,Q8IWU2 83 4.33e-02 425 9 2 0.222 0.005 MI:hsa-miR-615-3p mi 1 MI:hsa-miR-615-3p 1 Q8N350,Q8IWU2 83 4.37e-02 427 9 2 0.222 0.005 MI:hsa-miR-560 mi 1 MI:hsa-miR-560 1 Q8N350,Q8IWU2 83 4.39e-02 428 9 2 0.222 0.005 MI:hsa-miR-25 mi 1 MI:hsa-miR-25 1 Q9GZN8,Q9H792 83 4.44e-02 33 9 1 0.111 0.030 GO:0045022 BP 1 early endosome to late endosome transport 1 Q8IWU2 83 4.44e-02 33 9 1 0.111 0.030 GO:0051588 BP 1 regulation of neurotransmitter transport 1 Q9Y6H5 83 4.48e-02 433 9 2 0.222 0.005 MI:hsa-miR-423-3p mi 1 MI:hsa-miR-423-3p 1 Q8IWU2,Q96PV6 83 4.54e-02 436 9 2 0.222 0.005 MI:hsa-miR-122 mi 1 MI:hsa-miR-122 1 Q9Y6H5,Q8N350 83 4.56e-02 333 9 2 0.222 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 Q9H792,P36873 83 4.56e-02 333 9 2 0.222 0.006 GO:0005925 CC 1 focal adhesion 1 Q9H792,P36873 83 4.58e-02 34 9 1 0.111 0.029 GO:0018958 BP 1 phenol-containing compound metabolic process 1 Q9Y6H5 83 4.67e-02 337 9 2 0.222 0.006 GO:0030055 CC 1 cell-substrate junction 1 Q9H792,P36873 83 4.71e-02 35 9 1 0.111 0.029 GO:0032410 BP 1 negative regulation of transporter activity 1 Q8N350 83 4.71e-02 35 9 1 0.111 0.029 GO:0098927 BP 1 vesicle-mediated transport between endosomal compartments 1 Q8IWU2 83 4.73e-02 446 9 2 0.222 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q9GZN8,Q96PV6 83 4.75e-02 447 9 2 0.222 0.004 MI:hsa-miR-876-3p mi 1 MI:hsa-miR-876-3p 1 Q9Y6H5,P36873 83 4.79e-02 449 9 2 0.222 0.004 MI:hsa-miR-505 mi 1 MI:hsa-miR-505 1 Q9Y6H5,Q8N350 83 4.84e-02 36 9 1 0.111 0.028 GO:0008287 CC 1 protein serine/threonine phosphatase complex 1 P36873 83 4.84e-02 36 9 1 0.111 0.028 GO:1903293 CC 1 phosphatase complex 1 P36873 83 4.84e-02 36 9 1 0.111 0.028 GO:0004715 MF 1 non-membrane spanning protein tyrosine kinase activity 1 Q9H792 83 4.84e-02 36 9 1 0.111 0.028 GO:0006826 BP 1 iron ion transport 1 Q8IWU2 83 4.84e-02 36 9 1 0.111 0.028 GO:0034766 BP 1 negative regulation of ion transmembrane transport 1 Q8N350 83 4.85e-02 452 9 2 0.222 0.004 MI:mmu-miR-717 mi 1 MI:mmu-miR-717 1 Q9GZN8,P36873 83 4.87e-02 453 9 2 0.222 0.004 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 Q8N350,Q8IWU2 83 4.90e-02 346 9 2 0.222 0.006 GO:0030001 BP 1 metal ion transport 1 Q8N350,Q8IWU2 83 4.95e-02 457 9 2 0.222 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 Q9ULJ8,Q8IWU2 83 4.97e-02 458 9 2 0.222 0.004 MI:hsa-miR-296-5p mi 1 MI:hsa-miR-296-5p 1 Q8N350,Q8IWU2 83 4.97e-02 37 9 1 0.111 0.027 GO:0017022 MF 1 myosin binding 1 Q8IWU2 83 4.97e-02 37 9 1 0.111 0.027 GO:0017158 BP 1 regulation of calcium ion-dependent exocytosis 1 Q8N350 83 4.99e-02 459 9 2 0.222 0.004 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q9Y6H5,P36873 83 4.99e-02 459 9 2 0.222 0.004 MI:mmu-miR-762 mi 1 MI:mmu-miR-762 1 Q9GZN8,Q96PV6 83 5.00e-02 910 9 3 0.333 0.003 GO:0097708 CC 1 intracellular vesicle 1 Q9Y6H5,Q8N350,Q8IWU2 83 5.00e-02 9 9 1 0.111 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P36873 83 5.00e-02 1989 9 7 0.778 0.004 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q8N350,Q9GZN8,Q9H175,Q9ULJ8,Q8IWU2,Q9H792,P36873 83 5.00e-02 14 9 1 0.111 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P36873 84 3.35e-05 48 2 2 1.000 0.042 GO:0051310 BP 1 metaphase plate congression 1 Q53EZ4,Q8WVT3 84 4.41e-05 55 2 2 1.000 0.036 GO:0051303 BP 1 establishment of chromosome localization 1 Q53EZ4,Q8WVT3 84 4.57e-05 56 2 2 1.000 0.036 GO:0050000 BP 1 chromosome localization 1 Q53EZ4,Q8WVT3 84 2.08e-04 119 2 2 1.000 0.017 GO:0000070 BP 1 mitotic sister chromatid segregation 1 Q53EZ4,Q8WVT3 84 3.42e-04 1 2 1 0.500 1.000 GO:1902426 BP 1 deactivation of mitotic spindle assembly checkpoint 1 Q8WVT3 84 3.42e-04 1 2 1 0.500 1.000 GO:0090233 BP 1 negative regulation of spindle checkpoint 1 Q8WVT3 84 5.67e-04 196 2 2 1.000 0.010 GO:0000819 BP 1 sister chromatid segregation 1 Q53EZ4,Q8WVT3 84 6.85e-04 2 2 1 0.500 0.500 GO:1905340 BP 1 regulation of protein localization to kinetochore 1 Q8WVT3 84 6.85e-04 2 2 1 0.500 0.500 GO:1905342 BP 1 positive regulation of protein localization to kinetochore 1 Q8WVT3 84 7.55e-04 226 2 2 1.000 0.009 GO:0098813 BP 1 nuclear chromosome segregation 1 Q53EZ4,Q8WVT3 84 8.23e-04 236 2 2 1.000 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q53EZ4,Q8WVT3 84 1.02e-03 263 2 2 1.000 0.008 GO:0007059 BP 1 chromosome segregation 1 Q53EZ4,Q8WVT3 84 1.03e-03 3 2 1 0.500 0.333 GO:0090234 BP 1 regulation of kinetochore assembly 1 Q8WVT3 84 1.24e-03 289 2 2 1.000 0.007 GO:0051656 BP 1 establishment of organelle localization 1 Q53EZ4,Q8WVT3 84 1.37e-03 4 2 1 0.500 0.250 GO:1901977 BP 1 negative regulation of cell cycle checkpoint 1 Q8WVT3 84 1.37e-03 4 2 1 0.500 0.250 GO:0090230 BP 1 regulation of centromere complex assembly 1 Q8WVT3 84 1.41e-03 309 2 2 1.000 0.006 GO:0000280 BP 1 nuclear division 1 Q53EZ4,Q8WVT3 84 1.62e-03 331 2 2 1.000 0.006 GO:0051640 BP 1 organelle localization 1 Q53EZ4,Q8WVT3 84 1.71e-03 340 2 2 1.000 0.006 GO:0048285 BP 1 organelle fission 1 Q53EZ4,Q8WVT3 84 2.01e-03 503 2 2 1.000 0.004 MI:mmu-miR-693-3p mi 1 MI:mmu-miR-693-3p 1 Q53EZ4,Q8WVT3 84 2.05e-03 6 2 1 0.500 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q8WVT3 84 2.05e-03 6 2 1 0.500 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q8WVT3 84 2.05e-03 6 2 1 0.500 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q8WVT3 84 2.95e-03 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 Q53EZ4,Q8WVT3 84 3.47e-03 750 2 2 1.000 0.003 TF:M03923_1 tf 1 Factor: SP8; motif: RCCACGCCCMCY; match class: 1 1 Q53EZ4,Q8WVT3 84 3.76e-03 11 2 1 0.500 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q8WVT3 84 3.76e-03 11 2 1 0.500 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q8WVT3 84 3.76e-03 11 2 1 0.500 0.091 GO:0051382 BP 1 kinetochore assembly 1 Q8WVT3 84 4.11e-03 12 2 1 0.500 0.083 GO:0051383 BP 1 kinetochore organization 1 Q8WVT3 84 4.40e-03 28 2 1 0.500 0.036 TF:M06522_0 tf 1 Factor: ZNF519; motif: NGGGAGGGCGGM; match class: 0 1 Q8WVT3 84 4.45e-03 13 2 1 0.500 0.077 GO:0034501 BP 1 protein localization to kinetochore 1 Q8WVT3 84 4.79e-03 14 2 1 0.500 0.071 GO:0090231 BP 1 regulation of spindle checkpoint 1 Q8WVT3 84 5.47e-03 16 2 1 0.500 0.062 GO:0071459 BP 1 protein localization to chromosome, centromeric region 1 Q8WVT3 84 5.82e-03 17 2 1 0.500 0.059 GO:0000920 BP 1 cell separation after cytokinesis 1 Q53EZ4 84 6.40e-03 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q53EZ4,Q8WVT3 84 6.84e-03 20 2 1 0.500 0.050 GO:0051984 BP 1 positive regulation of chromosome segregation 1 Q8WVT3 84 7.70e-03 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q53EZ4,Q8WVT3 84 7.87e-03 23 2 1 0.500 0.043 GO:0007094 BP 1 mitotic spindle assembly checkpoint 1 Q8WVT3 84 8.00e-03 51 2 1 0.500 0.020 TF:M06981_0 tf 1 Factor: PRDM12; motif: NGACAGNTKACC; match class: 0 1 Q53EZ4 84 8.15e-03 52 2 1 0.500 0.019 TF:M06656_0 tf 1 Factor: ZNF436; motif: NTGGTGGGCGGA; match class: 0 1 Q8WVT3 84 8.21e-03 24 2 1 0.500 0.042 GO:0071173 BP 1 spindle assembly checkpoint 1 Q8WVT3 84 8.55e-03 25 2 1 0.500 0.040 GO:0045841 BP 1 negative regulation of mitotic metaphase/anaphase transition 1 Q8WVT3 84 8.55e-03 25 2 1 0.500 0.040 GO:1901976 BP 1 regulation of cell cycle checkpoint 1 Q8WVT3 84 8.55e-03 25 2 1 0.500 0.040 GO:0071174 BP 1 mitotic spindle checkpoint 1 Q8WVT3 84 8.55e-03 25 2 1 0.500 0.040 GO:2000816 BP 1 negative regulation of mitotic sister chromatid separation 1 Q8WVT3 84 8.55e-03 25 2 1 0.500 0.040 GO:0045840 BP 1 positive regulation of mitotic nuclear division 1 Q8WVT3 84 8.89e-03 26 2 1 0.500 0.038 GO:1902100 BP 1 negative regulation of metaphase/anaphase transition of cell cycle 1 Q8WVT3 84 9.23e-03 27 2 1 0.500 0.037 GO:0033048 BP 1 negative regulation of mitotic sister chromatid segregation 1 Q8WVT3 84 9.41e-03 60 2 1 0.500 0.017 TF:M06411_0 tf 1 Factor: ZNF662; motif: KGGGTAAAATGA; match class: 0 1 Q53EZ4 84 9.92e-03 29 2 1 0.500 0.034 GO:0051785 BP 1 positive regulation of nuclear division 1 Q8WVT3 84 9.92e-03 29 2 1 0.500 0.034 GO:0033046 BP 1 negative regulation of sister chromatid segregation 1 Q8WVT3 84 1.03e-02 30 2 1 0.500 0.033 GO:0051985 BP 1 negative regulation of chromosome segregation 1 Q8WVT3 84 1.03e-02 30 2 1 0.500 0.033 GO:0031577 BP 1 spindle checkpoint 1 Q8WVT3 84 1.05e-02 67 2 1 0.500 0.015 TF:M06487_0 tf 1 Factor: ZNF695; motif: NTKTAAGGAGNT; match class: 0 1 Q53EZ4 84 1.05e-02 67 2 1 0.500 0.015 TF:M00979_0 tf 1 Factor: Pax-6; motif: CTGACCTGGAACTM; match class: 0 1 Q8WVT3 84 1.06e-02 31 2 1 0.500 0.032 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 Q8WVT3 84 1.09e-02 32 2 1 0.500 0.031 GO:0000281 BP 1 mitotic cytokinesis 1 Q53EZ4 84 1.13e-02 33 2 1 0.500 0.030 GO:0045839 BP 1 negative regulation of mitotic nuclear division 1 Q8WVT3 84 1.16e-02 34 2 1 0.500 0.029 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 Q8WVT3 84 1.18e-02 75 2 1 0.500 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 Q8WVT3 84 1.20e-02 35 2 1 0.500 0.029 GO:0030071 BP 1 regulation of mitotic metaphase/anaphase transition 1 Q8WVT3 84 1.23e-02 36 2 1 0.500 0.028 GO:1902099 BP 1 regulation of metaphase/anaphase transition of cell cycle 1 Q8WVT3 84 1.26e-02 37 2 1 0.500 0.027 GO:0061640 BP 1 cytoskeleton-dependent cytokinesis 1 Q53EZ4 84 1.26e-02 37 2 1 0.500 0.027 GO:0007091 BP 1 metaphase/anaphase transition of mitotic cell cycle 1 Q8WVT3 84 1.26e-02 37 2 1 0.500 0.027 GO:0010965 BP 1 regulation of mitotic sister chromatid separation 1 Q8WVT3 84 1.26e-02 37 2 1 0.500 0.027 GO:0051784 BP 1 negative regulation of nuclear division 1 Q8WVT3 84 1.30e-02 38 2 1 0.500 0.026 GO:0051306 BP 1 mitotic sister chromatid separation 1 Q8WVT3 84 1.30e-02 38 2 1 0.500 0.026 GO:0034508 BP 1 centromere complex assembly 1 Q8WVT3 84 1.30e-02 38 2 1 0.500 0.026 GO:0044784 BP 1 metaphase/anaphase transition of cell cycle 1 Q8WVT3 84 1.34e-02 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 Q53EZ4,Q8WVT3 84 1.35e-02 1478 2 2 1.000 0.001 TF:M00630_1 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 1 1 Q53EZ4,Q8WVT3 84 1.40e-02 41 2 1 0.500 0.024 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q53EZ4 84 1.50e-02 44 2 1 0.500 0.023 GO:0033047 BP 1 regulation of mitotic sister chromatid segregation 1 Q8WVT3 84 1.57e-02 100 2 1 0.500 0.010 TF:M05668_0 tf 1 Factor: ZNF154; motif: NGTGAAATCAGA; match class: 0 1 Q53EZ4 84 1.58e-02 1601 2 2 1.000 0.001 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 Q53EZ4,Q8WVT3 84 1.78e-02 52 2 1 0.500 0.019 GO:2001251 BP 1 negative regulation of chromosome organization 1 Q8WVT3 84 1.81e-02 53 2 1 0.500 0.019 GO:0033045 BP 1 regulation of sister chromatid segregation 1 Q8WVT3 84 1.81e-02 53 2 1 0.500 0.019 GO:0051304 BP 1 chromosome separation 1 Q8WVT3 84 1.88e-02 55 2 1 0.500 0.018 GO:0034502 BP 1 protein localization to chromosome 1 Q8WVT3 84 1.89e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 Q53EZ4,Q8WVT3 84 1.98e-02 58 2 1 0.500 0.017 GO:2001252 BP 1 positive regulation of chromosome organization 1 Q8WVT3 84 2.02e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 Q53EZ4,Q8WVT3 84 2.13e-02 136 2 1 0.500 0.007 TF:M00157_1 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 1 1 Q53EZ4 84 2.17e-02 139 2 1 0.500 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 Q8WVT3 84 2.36e-02 69 2 1 0.500 0.014 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 Q8WVT3 84 2.36e-02 69 2 1 0.500 0.014 GO:0051983 BP 1 regulation of chromosome segregation 1 Q8WVT3 84 2.51e-02 161 2 1 0.500 0.006 TF:M05322_0 tf 1 Factor: T-box; motif: TTCACACCTR; match class: 0 1 Q8WVT3 84 2.63e-02 2066 2 2 1.000 0.001 TF:M05956_0 tf 1 Factor: CTIP-2; motif: RTMGTACAA; match class: 0 1 Q53EZ4,Q8WVT3 84 2.88e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 Q53EZ4,Q8WVT3 84 2.92e-02 2174 2 2 1.000 0.001 TF:M04303_0 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 0 1 Q53EZ4,Q8WVT3 84 2.99e-02 192 2 1 0.500 0.005 TF:M01119_0 tf 1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 0 1 Q53EZ4 84 3.10e-02 91 2 1 0.500 0.011 GO:0000776 CC 1 kinetochore 1 Q8WVT3 84 3.14e-02 2255 2 2 1.000 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 Q53EZ4,Q8WVT3 84 3.31e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 Q53EZ4,Q8WVT3 84 3.34e-02 98 2 1 0.500 0.010 GO:0030496 CC 1 midbody 1 Q53EZ4 84 3.44e-02 101 2 1 0.500 0.010 GO:0007088 BP 1 regulation of mitotic nuclear division 1 Q8WVT3 84 3.51e-02 103 2 1 0.500 0.010 GO:0006997 BP 1 nucleus organization 1 Q53EZ4 84 3.54e-02 227 2 1 0.500 0.004 TF:M00465_0 tf 1 Factor: POU6F1; motif: GCATAAWTTAT; match class: 0 1 Q8WVT3 84 3.65e-02 107 2 1 0.500 0.009 GO:0051783 BP 1 regulation of nuclear division 1 Q8WVT3 84 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q53EZ4,Q8WVT3 84 3.82e-02 112 2 1 0.500 0.009 GO:0000910 BP 1 cytokinesis 1 Q53EZ4 84 3.88e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 Q53EZ4,Q8WVT3 84 3.89e-02 250 2 1 0.500 0.004 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 Q53EZ4 84 3.99e-02 117 2 1 0.500 0.009 GO:1901991 BP 1 negative regulation of mitotic cell cycle phase transition 1 Q8WVT3 84 3.99e-02 117 2 1 0.500 0.009 GO:0033044 BP 1 regulation of chromosome organization 1 Q8WVT3 84 4.09e-02 120 2 1 0.500 0.008 GO:1901988 BP 1 negative regulation of cell cycle phase transition 1 Q8WVT3 84 4.10e-02 2578 2 2 1.000 0.001 TF:M02088_0 tf 1 Factor: E2A; motif: NRMCASCTGCNNN; match class: 0 1 Q53EZ4,Q8WVT3 84 4.12e-02 265 2 1 0.500 0.004 TF:M00775_1 tf 1 Factor: NF-Y; motif: NNNNRRCCAATSR; match class: 1 1 Q53EZ4 84 4.12e-02 121 2 1 0.500 0.008 GO:0000775 CC 1 chromosome, centromeric region 1 Q8WVT3 84 4.23e-02 272 2 1 0.500 0.004 TF:M06208_0 tf 1 Factor: ZNF460; motif: NGGGGGGGGGGG; match class: 0 1 Q53EZ4 84 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q53EZ4,Q8WVT3 84 4.36e-02 128 2 1 0.500 0.008 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 Q8WVT3 84 4.43e-02 130 2 1 0.500 0.008 GO:1902115 BP 1 regulation of organelle assembly 1 Q8WVT3 84 4.47e-02 288 2 1 0.500 0.003 TF:M07394_1 tf 1 Factor: slug; motif: CACCTGNNN; match class: 1 1 Q8WVT3 84 4.56e-02 134 2 1 0.500 0.007 GO:0065004 BP 1 protein-DNA complex assembly 1 Q8WVT3 84 4.66e-02 300 2 1 0.500 0.003 TF:M01182_0 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 0 1 Q8WVT3 84 4.95e-02 319 2 1 0.500 0.003 TF:M01022_1 tf 1 Factor: LEF-1; motif: NWTCAAAGNN; match class: 1 1 Q53EZ4 84 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q8WVT3 84 5.00e-02 1836 2 2 1.000 0.001 GO:0051641 BP 1 cellular localization 1 Q53EZ4,Q8WVT3 85 6.40e-04 219 4 3 0.750 0.014 GO:0016311 BP 1 dephosphorylation 1 Q9H175,Q6PJW8,P36873 85 2.97e-03 53 4 2 0.500 0.038 GO:0010923 BP 1 negative regulation of phosphatase activity 1 Q9H175,Q6PJW8 85 3.69e-03 59 4 2 0.500 0.034 GO:0035305 BP 1 negative regulation of dephosphorylation 1 Q9H175,Q6PJW8 85 5.20e-03 70 4 2 0.500 0.029 GO:0010921 BP 1 regulation of phosphatase activity 1 Q9H175,Q6PJW8 85 8.98e-03 92 4 2 0.500 0.022 GO:0035303 BP 1 regulation of dephosphorylation 1 Q9H175,Q6PJW8 85 9.24e-03 452 4 2 0.500 0.004 MI:mmu-miR-717 mi 1 MI:mmu-miR-717 1 Q6PJW8,P36873 85 9.52e-03 459 4 2 0.500 0.004 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q6PJW8,P36873 85 1.00e-02 164 4 2 0.500 0.012 TF:M07439_0 tf 1 Factor: TEF; motif: GTTACGTAAT; match class: 0 1 Q6PJW8,P36873 85 1.08e-02 101 4 2 0.500 0.020 GO:0019902 MF 1 phosphatase binding 1 Q9H175,Q6PJW8 85 1.11e-02 570 4 3 0.750 0.005 GO:0044092 BP 1 negative regulation of molecular function 1 Q8N350,Q9H175,Q6PJW8 85 1.25e-02 528 4 2 0.500 0.004 MI:hsa-miR-29a mi 1 MI:hsa-miR-29a 1 Q6PJW8,P36873 85 1.37e-02 553 4 2 0.500 0.004 MI:hsa-miR-29c mi 1 MI:hsa-miR-29c 1 Q6PJW8,P36873 85 1.67e-02 2 4 1 0.250 0.500 GO:0071253 MF 1 connexin binding 1 Q6PJW8 85 2.31e-02 250 4 2 0.500 0.008 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 Q8N350,Q9H175 85 2.50e-02 3 4 1 0.250 0.333 GO:0042998 BP 1 positive regulation of Golgi to plasma membrane protein transport 1 Q6PJW8 85 2.58e-02 8 4 1 0.250 0.125 TF:M05830_0 tf 1 Factor: ZNF66; motif: CAGCGGCGCCGCCG; match class: 0 1 P36873 85 3.06e-02 170 4 2 0.500 0.012 GO:0051346 BP 1 negative regulation of hydrolase activity 1 Q9H175,Q6PJW8 85 3.33e-02 1217 4 3 0.750 0.002 TF:M07226_1 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 1 Q8N350,Q9H175,P36873 85 3.33e-02 4 4 1 0.250 0.250 GO:1901386 BP 1 negative regulation of voltage-gated calcium channel activity 1 Q8N350 85 3.56e-02 879 4 2 0.500 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q9H175,Q6PJW8 85 4.20e-02 54 4 1 0.250 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 P36873 85 4.52e-02 14 4 1 0.250 0.071 TF:M07439_1 tf 1 Factor: TEF; motif: GTTACGTAAT; match class: 1 1 Q6PJW8 85 4.58e-02 59 4 1 0.250 0.017 KEGG:04720 keg 1 Long-term potentiation 1 P36873 85 5.00e-02 6 4 1 0.250 0.167 GO:0042996 BP 1 regulation of Golgi to plasma membrane protein transport 1 Q6PJW8 85 5.00e-02 14 4 1 0.250 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P36873 85 5.00e-02 9 4 1 0.250 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P36873 85 5.00e-02 370 4 2 0.500 0.005 TF:M06479_0 tf 1 Factor: HZF12; motif: NYCTCCGGRTGA; match class: 0 1 Q8N350,Q6PJW8 85 5.00e-02 6 4 1 0.250 0.167 GO:0045955 BP 1 negative regulation of calcium ion-dependent exocytosis 1 Q8N350 86 3.51e-03 2 4 1 0.250 0.500 CORUM:180 cor 1 PNUTS-PP1 complex 1 P62136 86 7.00e-03 392 4 2 0.500 0.005 MI:mmu-miR-702 mi 1 MI:mmu-miR-702 1 O75864,Q96S65 86 8.27e-03 427 4 2 0.500 0.005 MI:mmu-miR-697 mi 1 MI:mmu-miR-697 1 O75864,Q96S65 86 8.54e-03 434 4 2 0.500 0.005 MI:rno-miR-336 mi 1 MI:rno-miR-336 1 O75864,Q96S65 86 1.01e-02 472 4 2 0.500 0.004 MI:hsa-miR-525-5p mi 1 MI:hsa-miR-525-5p 1 O75864,Q96S65 86 1.41e-02 563 4 2 0.500 0.004 MI:hsa-miR-520a-5p mi 1 MI:hsa-miR-520a-5p 1 O75864,Q96S65 86 1.57e-02 9 4 1 0.250 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P62136 86 2.40e-02 2144 4 3 0.750 0.001 MI:rno-miR-000 mi 1 rno miRBase microRNAs 1 O75864,Q96S65,P62136 86 4.16e-02 4876 4 4 1.000 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 O75864,Q96S65,P62136,A8MZ97 86 4.20e-02 54 4 1 0.250 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 P62136 86 4.58e-02 59 4 1 0.250 0.017 KEGG:04720 keg 1 Long-term potentiation 1 P62136 86 5.00e-02 72 4 2 0.500 0.028 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 O75864,P62136 86 5.00e-02 14 4 1 0.250 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P62136 86 5.00e-02 29 4 1 0.250 0.034 CORUM:1183 cor 1 CDC5L complex 1 P62136 86 5.00e-02 1 4 1 0.250 1.000 GO:0036496 BP 1 regulation of translational initiation by eIF2 alpha dephosphorylation 1 P62136 87 8.85e-06 5 3 2 0.667 0.400 GO:0035032 CC 1 phosphatidylinositol 3-kinase complex, class III 1 Q6ZNE5,Q96F24 87 1.06e-04 16 3 2 0.667 0.125 GO:0005942 CC 1 phosphatidylinositol 3-kinase complex 1 Q6ZNE5,Q96F24 87 7.41e-03 1187 3 3 1.000 0.003 TF:M00410_1 tf 1 Factor: SOX9; motif: NNNNAACAATRGNN; match class: 1 1 Q6ZNE5,Q96F24,Q5TF21 87 1.02e-02 2 3 1 0.333 0.500 GO:0097629 CC 1 extrinsic component of omegasome membrane 1 Q6ZNE5 87 1.02e-02 2 3 1 0.333 0.500 GO:0097632 CC 1 extrinsic component of pre-autophagosomal structure membrane 1 Q6ZNE5 87 1.35e-02 176 3 2 0.667 0.011 GO:0019898 CC 1 extrinsic component of membrane 1 Q6ZNE5,Q96F24 87 1.53e-02 3 3 1 0.333 0.333 GO:1903349 CC 1 omegasome membrane 1 Q6ZNE5 87 2.03e-02 216 3 2 0.667 0.009 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q6ZNE5,Q96F24 87 2.43e-02 1764 3 3 1.000 0.002 TF:M04194_0 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 0 1 Q6ZNE5,Q96F24,Q5TF21 87 2.48e-02 1776 3 3 1.000 0.002 TF:M01843_1 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 1 1 Q6ZNE5,Q96F24,Q5TF21 87 2.55e-02 5 3 1 0.333 0.200 GO:0061635 BP 1 regulation of protein complex stability 1 Q6ZNE5 87 3.82e-02 2050 3 3 1.000 0.001 TF:M04571_0 tf 1 Factor: TFEC; motif: RNCACRTGAY; match class: 0 1 Q6ZNE5,Q96F24,Q5TF21 87 5.00e-02 32 3 1 0.333 0.031 REAC:383280 rea 1 Nuclear Receptor transcription pathway 1 Q96F24 87 5.00e-02 31 3 1 0.333 0.032 KEGG:04140 keg 1 Autophagy 1 Q6ZNE5 87 5.00e-02 2242 3 3 1.000 0.001 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q6ZNE5,Q96F24,Q5TF21 88 8.41e-04 2935 7 6 0.857 0.002 TF:M01889_1 tf 1 Factor: Smad4; motif: TGTCTGN; match class: 1 1 Q9C040,P63215,Q8N3J6,O00408,Q8TAC9,Q15649 88 1.65e-03 3 7 1 0.143 0.333 TF:M05774_0 tf 1 Factor: ZNF697; motif: KGGTACGAGGGM; match class: 0 1 Q15649 88 3.48e-03 168 7 2 0.286 0.012 TF:M06322_0 tf 1 Factor: ZNF181; motif: NCGGAAAGACGC; match class: 0 1 P63215,Q8TAC9 88 3.84e-03 7 7 1 0.143 0.143 TF:M00023_1 tf 1 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN; match class: 1 1 Q9C040 88 5.49e-03 10 7 1 0.143 0.100 TF:M04498_0 tf 1 Factor: VDR; motif: GRGTTCATYGRGTTCA; match class: 0 1 P63215 88 5.55e-03 731 7 3 0.429 0.004 TF:M04309_0 tf 1 Factor: DUXA; motif: NTRAYYTAATCAN; match class: 0 1 Q9C040,Q8N3J6,Q15649 88 5.64e-03 215 7 2 0.286 0.009 TF:M03948_1 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 1 Q9UHK0,O00408 88 6.54e-03 4208 7 6 0.857 0.001 TF:M00761_1 tf 1 Factor: p53; motif: RGRCAWGNCY; match class: 1 1 Q9UHK0,P63215,Q8N3J6,O00408,Q8TAC9,Q15649 88 7.24e-03 1658 7 4 0.571 0.002 TF:M07368_1 tf 1 Factor: Smad4; motif: NCAGACAN; match class: 1 1 P63215,Q8N3J6,O00408,Q15649 88 9.31e-03 17 7 1 0.143 0.059 TF:M03926_0 tf 1 Factor: ZBED1; motif: CTRTCGCGACATR; match class: 0 1 Q8N3J6 88 9.31e-03 17 7 1 0.143 0.059 TF:M06386_0 tf 1 Factor: ZNF836; motif: NGGTGAAGCCAG; match class: 0 1 O00408 88 1.48e-02 1040 7 3 0.429 0.003 TF:M05882_0 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 0 1 Q9UHK0,Q8TAC9,Q15649 88 1.53e-02 28 7 1 0.143 0.036 TF:M06695_0 tf 1 Factor: ZNF160; motif: CTAAATCCGC; match class: 0 1 Q9C040 88 1.61e-02 3348 7 5 0.714 0.001 TF:M01252_0 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 0 1 Q9UHK0,Q9C040,Q8N3J6,Q8TAC9,Q15649 88 1.72e-02 1 7 1 0.143 1.000 GO:0005726 CC 1 perichromatin fibrils 1 Q9UHK0 88 1.75e-02 387 7 2 0.286 0.005 TF:M04069_0 tf 1 Factor: POU1F1; motif: AWTATGCWAATKAG; match class: 0 1 Q8N3J6,Q15649 88 1.96e-02 36 7 1 0.143 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 Q9C040 88 2.04e-02 5169 7 6 0.857 0.001 TF:M02016_0 tf 1 Factor: HNF-4alpha; motif: GNNCAAAGKYCANNN; match class: 0 1 Q9UHK0,Q9C040,Q8N3J6,O00408,Q8TAC9,Q15649 88 2.14e-02 2242 7 4 0.571 0.002 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q9C040,P63215,O00408,Q8TAC9 88 2.24e-02 441 7 2 0.286 0.005 TF:M04079_0 tf 1 Factor: POU3F2; motif: WTATGCWAATKA; match class: 0 1 Q8N3J6,Q15649 88 2.28e-02 1219 7 3 0.429 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q9C040,P63215,Q15649 88 2.34e-02 43 7 1 0.143 0.023 TF:M07392_1 tf 1 Factor: Pitx3; motif: GGATTANNNNY; match class: 1 1 Q8N3J6 88 2.40e-02 44 7 1 0.143 0.023 TF:M04406_0 tf 1 Factor: MSX2; motif: GCAATTAAAWWSCAATTA; match class: 0 1 Q15649 88 2.45e-02 45 7 1 0.143 0.022 TF:M06367_0 tf 1 Factor: ZNF530; motif: KGGGGAAAAAKA; match class: 0 1 P63215 88 2.45e-02 407 7 2 0.286 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 P63215,O00408 88 2.47e-02 5351 7 6 0.857 0.001 TF:M00126_1 tf 1 Factor: GATA-1; motif: NNNNNGATANKGGN; match class: 1 1 Q9UHK0,Q9C040,P63215,O00408,Q8TAC9,Q15649 88 2.50e-02 46 7 1 0.143 0.022 TF:M05482_0 tf 1 Factor: ZFP202; motif: NGGGGCGAAT; match class: 0 1 Q15649 88 2.61e-02 48 7 1 0.143 0.021 TF:M06308_1 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 1 1 Q9C040 88 2.62e-02 5411 7 6 0.857 0.001 TF:M01888_0 tf 1 Factor: Smad3; motif: NGNCAGACASNNN; match class: 0 1 Q9UHK0,Q9C040,P63215,Q8N3J6,O00408,Q8TAC9 88 2.66e-02 49 7 1 0.143 0.020 TF:M03995_0 tf 1 Factor: SPIB; motif: NAAAAGMGGAAGTN; match class: 0 1 Q9C040 88 2.74e-02 2405 7 4 0.571 0.002 TF:M04071_0 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 0 1 Q9UHK0,Q9C040,Q8N3J6,O00408 88 2.93e-02 5521 7 6 0.857 0.001 TF:M02220_0 tf 1 Factor: HNF4A; motif: RGGNCAAAGKYCA; match class: 0 1 Q9UHK0,Q9C040,P63215,O00408,Q8TAC9,Q15649 88 3.03e-02 2478 7 4 0.571 0.002 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q9UHK0,Q8N3J6,Q8TAC9,Q15649 88 3.20e-02 59 7 1 0.143 0.017 TF:M04631_1 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 1 1 O00408 88 3.47e-02 64 7 1 0.143 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 Q8N3J6 88 3.54e-02 4006 7 5 0.714 0.001 TF:M00792_1 tf 1 Factor: SMAD; motif: AGACNBCNN; match class: 1 1 Q9C040,P63215,Q8N3J6,O00408,Q15649 88 3.60e-02 568 7 2 0.286 0.004 TF:M03948_0 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 0 1 Q9UHK0,O00408 88 3.62e-02 4027 7 5 0.714 0.001 TF:M07429_1 tf 1 Factor: SMAD3; motif: CAGACAS; match class: 1 1 Q9C040,P63215,Q8N3J6,O00408,Q15649 88 3.63e-02 67 7 1 0.143 0.015 TF:M06141_0 tf 1 Factor: ZNF708; motif: NGKGGAAAAGGW; match class: 0 1 Q8TAC9 88 3.71e-02 578 7 2 0.286 0.003 TF:M04013_1 tf 1 Factor: HSFY1; motif: TTCGAANSRTTCGAA; match class: 1 1 Q8TAC9,Q15649 88 3.73e-02 69 7 1 0.143 0.014 TF:M01256_0 tf 1 Factor: REST; motif: NNNNGGNGCTGTCCATGGTGCT; match class: 0 1 Q8TAC9 88 3.81e-02 497 7 2 0.286 0.004 HPA:007040_03 hpa 1 cerebral cortex; neuropil[Uncertain,High] 1 Q8N3J6,Q8TAC9 88 3.88e-02 592 7 2 0.286 0.003 TF:M01231_1 tf 1 Factor: ZNF515; motif: GTGGGGGGTM; match class: 1 1 Q9C040,O00408 88 3.89e-02 72 7 1 0.143 0.014 TF:M06225_0 tf 1 Factor: ZNF271; motif: NGGTCMAGACGM; match class: 0 1 Q15649 88 3.98e-02 4117 7 5 0.714 0.001 TF:M03921_0 tf 1 Factor: SP3; motif: NCCACGCCCMC; match class: 0 1 Q9C040,P63215,Q8N3J6,O00408,Q15649 88 4.10e-02 1519 7 3 0.429 0.002 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 Q9UHK0,Q9C040,Q15649 88 4.17e-02 5896 7 6 0.857 0.001 TF:M00626_0 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 0 1 Q9UHK0,Q9C040,Q8N3J6,O00408,Q8TAC9,Q15649 88 4.19e-02 1531 7 3 0.429 0.002 TF:M00806_1 tf 1 Factor: NF-1; motif: NTGGNNNNNNGCCAANN; match class: 1 1 Q9C040,O00408,Q15649 88 4.53e-02 644 7 2 0.286 0.003 TF:M05962_0 tf 1 Factor: PRDM16; motif: NGKGCCSGCMT; match class: 0 1 O00408,Q15649 88 4.69e-02 87 7 1 0.143 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 P63215 88 4.80e-02 1614 7 3 0.429 0.002 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 Q9UHK0,Q9C040,Q15649 88 4.90e-02 672 7 2 0.286 0.003 TF:M07207_0 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 0 1 P63215,O00408 88 4.95e-02 92 7 1 0.143 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 Q8N3J6 88 4.95e-02 92 7 1 0.143 0.011 TF:M04400_1 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 1 1 Q8N3J6 88 4.99e-02 4343 7 5 0.714 0.001 TF:M00807_0 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 0 1 Q9UHK0,P63215,Q8N3J6,O00408,Q15649 88 5.00e-02 72 7 2 0.286 0.028 KEGG:05032 keg 1 Morphine addiction 1 P63215,O00408 88 5.00e-02 108 7 2 0.286 0.019 GO:0098793 CC 1 presynapse 1 Q9UHK0,O00408 88 5.00e-02 1 7 1 0.143 1.000 OMIM:615490 omi 1 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R; CMT2R;;CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 2R;;CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL RECESSIVE, TYPE 2R 1 Q9C040 88 5.00e-02 67 7 2 0.286 0.030 REAC:418555 rea 1 G alpha (s) signalling events 1 P63215,O00408 89 6.93e-04 1 2 1 0.500 1.000 GO:0046452 BP 1 dihydrofolate metabolic process 1 P00374 89 6.93e-04 1 2 1 0.500 1.000 GO:0031427 BP 1 response to methotrexate 1 P00374 89 6.93e-04 1 2 1 0.500 1.000 GO:0051870 MF 1 methotrexate binding 1 P00374 89 6.93e-04 1 2 1 0.500 1.000 GO:0033560 MF 1 folate reductase activity 1 P00374 89 1.39e-03 2 2 1 0.500 0.500 GO:0046654 BP 1 tetrahydrofolate biosynthetic process 1 P00374 89 1.39e-03 2 2 1 0.500 0.500 GO:0004146 MF 1 dihydrofolate reductase activity 1 P00374 89 2.77e-03 4 2 1 0.500 0.250 GO:0005542 MF 1 folic acid binding 1 P00374 89 2.77e-03 4 2 1 0.500 0.250 GO:0006729 BP 1 tetrahydrobiopterin biosynthetic process 1 P00374 89 2.77e-03 4 2 1 0.500 0.250 GO:0046146 BP 1 tetrahydrobiopterin metabolic process 1 P00374 89 3.46e-03 5 2 1 0.500 0.200 GO:0009396 BP 1 folic acid-containing compound biosynthetic process 1 P00374 89 4.85e-03 7 2 1 0.500 0.143 GO:2000121 BP 1 regulation of removal of superoxide radicals 1 P00374 89 5.26e-03 9 2 1 0.500 0.111 REAC:1474151 rea 1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 1 P00374 89 5.54e-03 8 2 1 0.500 0.125 GO:0042559 BP 1 pteridine-containing compound biosynthetic process 1 P00374 89 6.92e-03 10 2 1 0.500 0.100 GO:0034497 BP 1 protein localization to pre-autophagosomal structure 1 Q5MNZ6 89 6.92e-03 10 2 1 0.500 0.100 GO:0051000 BP 1 positive regulation of nitric-oxide synthase activity 1 P00374 89 6.92e-03 10 2 1 0.500 0.100 GO:0070402 MF 1 NADPH binding 1 P00374 89 7.61e-03 11 2 1 0.500 0.091 GO:0031103 BP 1 axon regeneration 1 P00374 89 7.61e-03 11 2 1 0.500 0.091 GO:0034045 CC 1 pre-autophagosomal structure membrane 1 Q5MNZ6 89 8.31e-03 12 2 1 0.500 0.083 GO:0046653 BP 1 tetrahydrofolate metabolic process 1 P00374 89 9.00e-03 13 2 1 0.500 0.077 GO:0071451 BP 1 cellular response to superoxide 1 P00374 89 9.00e-03 13 2 1 0.500 0.077 GO:0071450 BP 1 cellular response to oxygen radical 1 P00374 89 9.00e-03 13 2 1 0.500 0.077 GO:0031102 BP 1 neuron projection regeneration 1 P00374 89 9.00e-03 13 2 1 0.500 0.077 GO:0000303 BP 1 response to superoxide 1 P00374 89 9.00e-03 13 2 1 0.500 0.077 GO:0019430 BP 1 removal of superoxide radicals 1 P00374 89 9.35e-03 16 2 1 0.500 0.062 REAC:196757 rea 1 Metabolism of folate and pterines 1 P00374 89 9.69e-03 14 2 1 0.500 0.071 GO:0090322 BP 1 regulation of superoxide metabolic process 1 P00374 89 9.69e-03 14 2 1 0.500 0.071 GO:0000305 BP 1 response to oxygen radical 1 P00374 89 9.69e-03 14 2 1 0.500 0.071 GO:0032770 BP 1 positive regulation of monooxygenase activity 1 P00374 89 9.69e-03 14 2 1 0.500 0.071 GO:0048678 BP 1 response to axon injury 1 P00374 89 1.04e-02 15 2 1 0.500 0.067 GO:0098869 BP 1 cellular oxidant detoxification 1 P00374 89 1.05e-02 18 2 1 0.500 0.056 REAC:69205 rea 1 G1/S-Specific Transcription 1 P00374 89 1.11e-02 16 2 1 0.500 0.062 GO:0046655 BP 1 folic acid metabolic process 1 P00374 89 1.11e-02 19 2 1 0.500 0.053 REAC:202131 rea 1 Metabolism of nitric oxide 1 P00374 89 1.11e-02 19 2 1 0.500 0.053 REAC:203765 rea 1 eNOS activation and regulation 1 P00374 89 1.18e-02 17 2 1 0.500 0.059 GO:0016646 MF 1 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1 P00374 89 1.25e-02 18 2 1 0.500 0.056 GO:0044804 BP 1 nucleophagy 1 Q5MNZ6 89 1.25e-02 18 2 1 0.500 0.056 GO:1990748 BP 1 cellular detoxification 1 P00374 89 1.25e-02 751 2 2 1.000 0.003 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 Q5MNZ6,P00374 89 1.31e-02 19 2 1 0.500 0.053 GO:0080025 MF 1 phosphatidylinositol-3,5-bisphosphate binding 1 Q5MNZ6 89 1.31e-02 19 2 1 0.500 0.053 GO:0019842 MF 1 vitamin binding 1 P00374 89 1.33e-02 774 2 2 1.000 0.003 TF:M03914_1 tf 1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 1 Q5MNZ6,P00374 89 1.38e-02 20 2 1 0.500 0.050 GO:0006760 BP 1 folic acid-containing compound metabolic process 1 P00374 89 1.38e-02 20 2 1 0.500 0.050 GO:0098754 BP 1 detoxification 1 P00374 89 1.38e-02 20 2 1 0.500 0.050 GO:1901031 BP 1 regulation of response to reactive oxygen species 1 P00374 89 1.41e-02 25 2 1 0.500 0.040 TF:M00516_1 tf 1 Factor: E2F; motif: TTTSGCGCGMNR; match class: 1 1 P00374 89 1.52e-02 22 2 1 0.500 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 P00374 89 1.58e-02 28 2 1 0.500 0.036 TF:M06846_1 tf 1 Factor: ZFHX2; motif: WGWGGTCCCCC; match class: 1 1 Q5MNZ6 89 1.59e-02 23 2 1 0.500 0.043 GO:0042398 BP 1 cellular modified amino acid biosynthetic process 1 P00374 89 1.66e-02 24 2 1 0.500 0.042 GO:0051353 BP 1 positive regulation of oxidoreductase activity 1 P00374 89 1.66e-02 24 2 1 0.500 0.042 GO:0042558 BP 1 pteridine-containing compound metabolic process 1 P00374 89 1.66e-02 24 2 1 0.500 0.042 GO:0032266 MF 1 phosphatidylinositol-3-phosphate binding 1 Q5MNZ6 89 1.66e-02 24 2 1 0.500 0.042 GO:0016645 MF 1 oxidoreductase activity, acting on the CH-NH group of donors 1 P00374 89 1.67e-02 13 2 1 0.500 0.077 HP:0001889 hp 1 Megaloblastic anemia 1 P00374 89 1.73e-02 25 2 1 0.500 0.040 GO:0050661 MF 1 NADP binding 1 P00374 89 1.73e-02 25 2 1 0.500 0.040 GO:0000407 CC 1 pre-autophagosomal structure 1 Q5MNZ6 89 1.80e-02 26 2 1 0.500 0.038 GO:0031099 BP 1 regeneration 1 P00374 89 1.81e-02 904 2 2 1.000 0.002 TF:M01273_1 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 1 Q5MNZ6,P00374 89 1.94e-02 28 2 1 0.500 0.036 GO:0006801 BP 1 superoxide metabolic process 1 P00374 89 1.97e-02 35 2 1 0.500 0.029 TF:M05525_0 tf 1 Factor: ZBTB41; motif: TGGGCCCCCGA; match class: 0 1 Q5MNZ6 89 1.98e-02 34 2 1 0.500 0.029 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 P00374 89 2.01e-02 29 2 1 0.500 0.034 GO:0050999 BP 1 regulation of nitric-oxide synthase activity 1 P00374 89 2.05e-02 826 2 2 1.000 0.002 GO:0043168 MF 1 anion binding 1 Q5MNZ6,P00374 89 2.42e-02 35 2 1 0.500 0.029 GO:0072341 MF 1 modified amino acid binding 1 P00374 89 2.49e-02 36 2 1 0.500 0.028 GO:0032768 BP 1 regulation of monooxygenase activity 1 P00374 89 2.63e-02 38 2 1 0.500 0.026 GO:0009636 BP 1 response to toxic substance 1 P00374 89 2.77e-02 40 2 1 0.500 0.025 GO:1900407 BP 1 regulation of cellular response to oxidative stress 1 P00374 89 2.90e-02 42 2 1 0.500 0.024 GO:1902882 BP 1 regulation of response to oxidative stress 1 P00374 89 3.14e-02 1191 2 2 1.000 0.002 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q5MNZ6,P00374 89 3.21e-02 25 2 1 0.500 0.040 HP:0002121 hp 1 Absence seizures 1 P00374 89 3.28e-02 1217 2 2 1.000 0.002 TF:M07226_1 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 1 Q5MNZ6,P00374 89 3.59e-02 52 2 1 0.500 0.019 GO:0008144 MF 1 drug binding 1 P00374 89 3.66e-02 53 2 1 0.500 0.019 GO:0051341 BP 1 regulation of oxidoreductase activity 1 P00374 89 3.84e-02 66 2 1 0.500 0.015 REAC:1632852 rea 1 Macroautophagy 1 Q5MNZ6 89 3.89e-02 14 2 1 0.500 0.071 KEGG:00790 keg 1 Folate biosynthesis 1 P00374 89 4.08e-02 59 2 1 0.500 0.017 GO:1902936 MF 1 phosphatidylinositol bisphosphate binding 1 Q5MNZ6 89 4.35e-02 63 2 1 0.500 0.016 GO:0006497 BP 1 protein lipidation 1 Q5MNZ6 89 4.42e-02 64 2 1 0.500 0.016 GO:0043648 BP 1 dicarboxylic acid metabolic process 1 P00374 89 4.49e-02 65 2 1 0.500 0.015 GO:0034614 BP 1 cellular response to reactive oxygen species 1 P00374 89 4.56e-02 66 2 1 0.500 0.015 GO:0000422 BP 1 mitophagy 1 Q5MNZ6 89 4.56e-02 66 2 1 0.500 0.015 GO:0061726 BP 1 mitochondrion disassembly 1 Q5MNZ6 89 4.70e-02 68 2 1 0.500 0.015 GO:0042158 BP 1 lipoprotein biosynthetic process 1 Q5MNZ6 89 4.76e-02 69 2 1 0.500 0.014 GO:0000045 BP 1 autophagosome assembly 1 Q5MNZ6 89 4.83e-02 70 2 1 0.500 0.014 GO:0006767 BP 1 water-soluble vitamin metabolic process 1 P00374 89 4.83e-02 70 2 1 0.500 0.014 GO:1905037 BP 1 autophagosome organization 1 Q5MNZ6 89 4.87e-02 38 2 1 0.500 0.026 HP:0002421 hp 1 Poor head control 1 P00374 89 5.00e-02 1 2 1 0.500 1.000 OMIM:613839 omi 1 MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY;;DHFR DEFICIENCY 1 P00374 89 5.00e-02 86 2 1 0.500 0.012 REAC:196849 rea 1 Metabolism of water-soluble vitamins and cofactors 1 P00374 89 5.00e-02 1291 2 2 1.000 0.002 GO:0043167 MF 1 ion binding 1 Q5MNZ6,P00374 89 5.00e-02 39 2 1 0.500 0.026 HP:0001972 hp 1 Macrocytic anemia 1 P00374 89 5.00e-02 1503 2 2 1.000 0.001 TF:M00976_0 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 0 1 Q5MNZ6,P00374 89 5.00e-02 18 2 1 0.500 0.056 KEGG:00670 keg 1 One carbon pool by folate 1 P00374 90 2.93e-07 23 5 3 0.600 0.130 GO:0034451 CC 1 centriolar satellite 1 O75665,Q15154,Q49A88 90 3.21e-05 409 5 4 0.800 0.010 GO:0005813 CC 1 centrosome 1 O75665,Q15154,Q1MSJ5,Q49A88 90 3.93e-05 114 5 3 0.600 0.026 GO:0044450 CC 1 microtubule organizing center part 1 O75665,Q15154,Q49A88 90 5.78e-05 474 5 4 0.800 0.008 GO:0005815 CC 1 microtubule organizing center 1 O75665,Q15154,Q1MSJ5,Q49A88 90 8.65e-05 17 5 2 0.400 0.118 GO:1905508 BP 1 protein localization to microtubule organizing center 1 Q15154,Q49A88 90 8.65e-05 17 5 2 0.400 0.118 GO:0071539 BP 1 protein localization to centrosome 1 Q15154,Q49A88 90 1.90e-04 25 5 2 0.400 0.080 GO:0072698 BP 1 protein localization to microtubule cytoskeleton 1 Q15154,Q49A88 90 2.23e-04 27 5 2 0.400 0.074 GO:0044380 BP 1 protein localization to cytoskeleton 1 Q15154,Q49A88 90 3.94e-04 769 5 4 0.800 0.005 GO:0015630 CC 1 microtubule cytoskeleton 1 O75665,Q15154,Q1MSJ5,Q49A88 90 8.44e-04 933 5 4 0.800 0.004 GO:0044430 CC 1 cytoskeletal part 1 O75665,Q15154,Q1MSJ5,Q49A88 90 1.19e-03 66 5 2 0.400 0.030 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 O75665,Q15154 90 1.19e-03 66 5 2 0.400 0.030 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 O75665,Q15154 90 1.30e-03 69 5 2 0.400 0.029 REAC:8854518 rea 1 AURKA Activation by TPX2 1 O75665,Q15154 90 1.54e-03 75 5 2 0.400 0.027 REAC:380287 rea 1 Centrosome maturation 1 O75665,Q15154 90 1.54e-03 75 5 2 0.400 0.027 REAC:380270 rea 1 Recruitment of mitotic centrosome proteins and complexes 1 O75665,Q15154 90 1.88e-03 83 5 2 0.400 0.024 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 O75665,Q15154 90 2.30e-03 1204 5 4 0.800 0.003 GO:0005856 CC 1 cytoskeleton 1 O75665,Q15154,Q1MSJ5,Q49A88 90 2.31e-03 92 5 2 0.400 0.022 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 O75665,Q15154 90 2.38e-03 16 5 2 0.400 0.125 HP:0000180 hp 1 Lobulated tongue 1 O75665,Q1MSJ5 90 2.92e-03 97 5 2 0.400 0.021 GO:0051297 BP 1 centrosome organization 1 O75665,Q15154 90 3.48e-03 106 5 2 0.400 0.019 GO:0031023 BP 1 microtubule organizing center organization 1 O75665,Q15154 90 5.51e-03 3 5 1 0.200 0.333 GO:0022027 BP 1 interkinetic nuclear migration 1 Q15154 90 6.23e-03 142 5 2 0.400 0.014 GO:0044782 BP 1 cilium organization 1 O75665,Q15154 90 7.31e-03 154 5 2 0.400 0.013 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 O75665,Q15154 90 7.44e-03 28 5 2 0.400 0.071 HP:0002419 hp 1 Molar tooth sign on MRI 1 O75665,Q1MSJ5 90 7.85e-03 171 5 2 0.400 0.012 REAC:69275 rea 1 G2/M Transition 1 O75665,Q15154 90 7.99e-03 161 5 2 0.400 0.012 GO:0044839 BP 1 cell cycle G2/M phase transition 1 O75665,Q15154 90 8.03e-03 173 5 2 0.400 0.012 REAC:5617833 rea 1 Assembly of the primary cilium 1 O75665,Q15154 90 8.03e-03 173 5 2 0.400 0.012 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 O75665,Q15154 90 9.00e-03 171 5 2 0.400 0.012 GO:0007018 BP 1 microtubule-based movement 1 O75665,Q15154 90 9.13e-03 31 5 2 0.400 0.065 HP:0007973 hp 1 Retinal dysplasia 1 O75665,Q1MSJ5 90 9.18e-03 5 5 1 0.200 0.200 GO:0035735 BP 1 intraciliary transport involved in cilium assembly 1 Q15154 90 9.20e-03 351 5 2 0.400 0.006 MI:hsa-miR-135b* mi 1 MI:hsa-miR-135b* 1 Q15154,Q96KV7 90 1.07e-02 380 5 2 0.400 0.005 MI:hsa-miR-662 mi 1 MI:hsa-miR-662 1 O75665,Q96KV7 90 1.10e-02 34 5 2 0.400 0.059 HP:0001737 hp 1 Pancreatic cysts 1 O75665,Q1MSJ5 90 1.10e-02 6 5 1 0.200 0.167 GO:0034454 BP 1 microtubule anchoring at centrosome 1 Q15154 90 1.11e-02 386 5 2 0.400 0.005 MI:hsa-miR-624 mi 1 MI:hsa-miR-624 1 Q96KV7,Q49A88 90 1.22e-02 406 5 2 0.400 0.005 MI:mmu-miR-468 mi 1 MI:mmu-miR-468 1 O75665,Q96KV7 90 1.29e-02 7 5 1 0.200 0.143 GO:0060287 BP 1 epithelial cilium movement involved in determination of left/right asymmetry 1 O75665 90 1.30e-02 206 5 2 0.400 0.010 GO:0060271 BP 1 cilium assembly 1 O75665,Q15154 90 1.35e-02 210 5 2 0.400 0.010 GO:0007420 BP 1 brain development 1 Q15154,Q49A88 90 1.37e-02 38 5 2 0.400 0.053 HP:0006706 hp 1 Cystic liver disease 1 O75665,Q1MSJ5 90 1.47e-02 219 5 2 0.400 0.009 GO:0060322 BP 1 head development 1 Q15154,Q49A88 90 1.47e-02 8 5 1 0.200 0.125 GO:0072393 BP 1 microtubule anchoring at microtubule organizing center 1 Q15154 90 1.47e-02 8 5 1 0.200 0.125 GO:0021846 BP 1 cell proliferation in forebrain 1 Q15154 90 1.48e-02 220 5 2 0.400 0.009 GO:0044441 CC 1 ciliary part 1 O75665,Q15154 90 1.52e-02 40 5 2 0.400 0.050 HP:0002418 hp 1 Abnormality of midbrain morphology 1 O75665,Q1MSJ5 90 1.52e-02 1960 5 4 0.800 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 O75665,Q15154,Q1MSJ5,Q49A88 90 1.52e-02 1960 5 4 0.800 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 O75665,Q15154,Q1MSJ5,Q49A88 90 1.54e-02 459 5 2 0.400 0.004 MI:hsa-miR-299-5p mi 1 MI:hsa-miR-299-5p 1 Q1MSJ5,Q96KV7 90 1.54e-02 459 5 2 0.400 0.004 MI:hsa-miR-33b mi 1 MI:hsa-miR-33b 1 Q15154,Q96KV7 90 1.56e-02 462 5 2 0.400 0.004 MI:hsa-miR-485-3p mi 1 MI:hsa-miR-485-3p 1 O75665,Q96KV7 90 1.58e-02 464 5 2 0.400 0.004 MI:hsa-miR-545 mi 1 MI:hsa-miR-545 1 O75665,Q1MSJ5 90 1.62e-02 470 5 2 0.400 0.004 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 Q15154,Q49A88 90 1.73e-02 238 5 2 0.400 0.008 GO:0030031 BP 1 cell projection assembly 1 O75665,Q15154 90 1.87e-02 507 5 2 0.400 0.004 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 Q1MSJ5,Q96KV7 90 2.01e-02 46 5 2 0.400 0.043 HP:0001177 hp 1 Preaxial hand polydactyly 1 O75665,Q1MSJ5 90 2.02e-02 11 5 1 0.200 0.091 GO:0003351 BP 1 epithelial cilium movement 1 O75665 90 2.02e-02 11 5 1 0.200 0.091 GO:0051647 BP 1 nucleus localization 1 Q15154 90 2.09e-02 952 5 3 0.600 0.003 GO:0022402 BP 1 cell cycle process 1 O75665,Q15154,Q1MSJ5 90 2.10e-02 47 5 2 0.400 0.043 HP:0001746 hp 1 Asplenia 1 O75665,Q1MSJ5 90 2.16e-02 267 5 2 0.400 0.007 GO:0005929 CC 1 cilium 1 O75665,Q15154 90 2.19e-02 48 5 2 0.400 0.042 HP:0002435 hp 1 Meningocele 1 O75665,Q1MSJ5 90 2.20e-02 12 5 1 0.200 0.083 GO:0043014 MF 1 alpha-tubulin binding 1 O75665 90 2.55e-02 314 5 2 0.400 0.006 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 O75665,Q15154 90 2.57e-02 14 5 1 0.200 0.071 GO:0034453 BP 1 microtubule anchoring 1 Q15154 90 2.57e-02 14 5 1 0.200 0.071 GO:0000242 CC 1 pericentriolar material 1 Q15154 90 2.66e-02 53 5 2 0.400 0.038 HP:0010451 hp 1 Aplasia/Hypoplasia of the spleen 1 O75665,Q1MSJ5 90 2.76e-02 54 5 2 0.400 0.037 HP:0009799 hp 1 Supernumerary spleens 1 O75665,Q1MSJ5 90 2.84e-02 307 5 2 0.400 0.007 GO:0007417 BP 1 central nervous system development 1 Q15154,Q49A88 90 2.97e-02 56 5 2 0.400 0.036 HP:0011425 hp 1 Fetal ultrasound soft marker 1 O75665,Q1MSJ5 90 2.97e-02 56 5 2 0.400 0.036 HP:0012090 hp 1 Abnormality of pancreas morphology 1 O75665,Q1MSJ5 90 3.23e-02 653 5 2 0.400 0.003 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 O75665,Q15154 90 3.27e-02 330 5 2 0.400 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 O75665,Q15154 90 3.30e-02 18 5 1 0.200 0.056 GO:0043015 MF 1 gamma-tubulin binding 1 O75665 90 3.40e-02 1128 5 3 0.600 0.003 GO:0007049 BP 1 cell cycle 1 O75665,Q15154,Q1MSJ5 90 3.74e-02 63 5 2 0.400 0.032 HP:0100258 hp 1 Preaxial polydactyly 1 O75665,Q1MSJ5 90 3.85e-02 21 5 1 0.200 0.048 GO:0099118 BP 1 microtubule-based protein transport 1 Q15154 90 3.85e-02 21 5 1 0.200 0.048 GO:0042073 BP 1 intraciliary transport 1 Q15154 90 3.85e-02 21 5 1 0.200 0.048 GO:0098840 BP 1 protein transport along microtubule 1 Q15154 90 3.85e-02 21 5 1 0.200 0.048 GO:1905515 BP 1 non-motile cilium assembly 1 Q15154 90 4.04e-02 3 5 1 0.200 0.333 HP:0009085 hp 1 Alveolar ridge overgrowth 1 O75665 90 4.04e-02 3 5 1 0.200 0.333 HP:0000199 hp 1 Tongue nodules 1 O75665 90 4.23e-02 67 5 2 0.400 0.030 HP:0010651 hp 1 Abnormality of the meninges 1 O75665,Q1MSJ5 90 4.58e-02 25 5 1 0.200 0.040 GO:0032467 BP 1 positive regulation of cytokinesis 1 Q1MSJ5 90 4.94e-02 27 5 1 0.200 0.037 GO:0007099 BP 1 centriole replication 1 O75665 90 4.95e-02 409 5 2 0.400 0.005 GO:0044463 CC 1 cell projection part 1 O75665,Q15154 90 5.00e-02 73 5 2 0.400 0.027 HP:0000657 hp 1 Oculomotor apraxia 1 O75665,Q1MSJ5 90 5.00e-02 20 5 2 0.400 0.100 OMIM:213300 omi 1 Joubert Syndrome 1 O75665,Q1MSJ5 90 5.00e-02 448 5 2 0.400 0.004 REAC:69278 rea 1 Cell Cycle, Mitotic 1 O75665,Q15154 90 5.00e-02 103 5 2 0.400 0.019 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q15154,Q96KV7 90 5.00e-02 411 5 2 0.400 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 O75665,Q15154 91 8.38e-04 1 3 1 0.333 1.000 GO:0030238 BP 1 male sex determination 1 Q9UIU6 91 8.38e-04 1 3 1 0.333 1.000 GO:0061551 BP 1 trigeminal ganglion development 1 Q9UIU6 91 8.38e-04 1 3 1 0.333 1.000 GO:0061055 BP 1 myotome development 1 Q9UIU6 91 8.38e-04 1 3 1 0.333 1.000 GO:0061550 BP 1 cranial ganglion development 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:0098528 BP 1 skeletal muscle fiber differentiation 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:1902725 BP 1 negative regulation of satellite cell differentiation 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:0071699 BP 1 olfactory placode morphogenesis 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:0072095 BP 1 regulation of branch elongation involved in ureteric bud branching 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:0030910 BP 1 olfactory placode formation 1 Q9UIU6 91 1.68e-03 2 3 1 0.333 0.500 GO:0071698 BP 1 olfactory placode development 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0014816 BP 1 skeletal muscle satellite cell differentiation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0060681 BP 1 branch elongation involved in ureteric bud branching 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0061197 BP 1 fungiform papilla morphogenesis 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0072172 BP 1 mesonephric tubule formation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0061196 BP 1 fungiform papilla development 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0072106 BP 1 regulation of ureteric bud formation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0072107 BP 1 positive regulation of ureteric bud formation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:1905278 BP 1 positive regulation of epithelial tube formation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:0060676 BP 1 ureteric bud formation 1 Q9UIU6 91 2.51e-03 3 3 1 0.333 0.333 GO:2001015 BP 1 negative regulation of skeletal muscle cell differentiation 1 Q9UIU6 91 2.59e-03 11 3 1 0.333 0.091 TF:M05486_0 tf 1 Factor: Blimp-1; motif: NTGTTTTGGATA; match class: 0 1 Q86VP3 91 2.87e-03 1111 3 3 1.000 0.003 GO:0034613 BP 1 cellular protein localization 1 Q9UIU6,Q96FV0,Q86VP3 91 2.95e-03 1121 3 3 1.000 0.003 GO:0070727 BP 1 cellular macromolecule localization 1 Q9UIU6,Q96FV0,Q86VP3 91 3.35e-03 4 3 1 0.333 0.250 GO:0060677 BP 1 ureteric bud elongation 1 Q9UIU6 91 3.35e-03 4 3 1 0.333 0.250 GO:0072079 BP 1 nephron tubule formation 1 Q9UIU6 91 3.35e-03 4 3 1 0.333 0.250 GO:0043587 BP 1 tongue morphogenesis 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0060602 BP 1 branch elongation of an epithelium 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0060788 BP 1 ectodermal placode formation 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0048642 BP 1 negative regulation of skeletal muscle tissue development 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0071696 BP 1 ectodermal placode development 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0071697 BP 1 ectodermal placode morphogenesis 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0043584 BP 1 nose development 1 Q9UIU6 91 4.19e-03 5 3 1 0.333 0.200 GO:0043586 BP 1 tongue development 1 Q9UIU6 91 5.02e-03 6 3 1 0.333 0.167 GO:0007530 BP 1 sex determination 1 Q9UIU6 91 5.43e-03 550 3 2 0.667 0.004 TF:M00490_0 tf 1 Factor: Bach2; motif: SRTGAGTCANC; match class: 0 1 Q9UIU6,Q86VP3 91 5.66e-03 1393 3 3 1.000 0.002 GO:0008104 BP 1 protein localization 1 Q9UIU6,Q96FV0,Q86VP3 91 5.86e-03 7 3 1 0.333 0.143 GO:0072074 BP 1 kidney mesenchyme development 1 Q9UIU6 91 5.86e-03 7 3 1 0.333 0.143 GO:1905276 BP 1 regulation of epithelial tube formation 1 Q9UIU6 91 5.86e-03 7 3 1 0.333 0.143 GO:0072075 BP 1 metanephric mesenchyme development 1 Q9UIU6 91 6.70e-03 8 3 1 0.333 0.125 GO:0003401 BP 1 axis elongation 1 Q9UIU6 91 6.70e-03 8 3 1 0.333 0.125 GO:0061548 BP 1 ganglion development 1 Q9UIU6 91 6.70e-03 8 3 1 0.333 0.125 GO:0090189 BP 1 regulation of branching involved in ureteric bud morphogenesis 1 Q9UIU6 91 6.70e-03 8 3 1 0.333 0.125 GO:0090190 BP 1 positive regulation of branching involved in ureteric bud morphogenesis 1 Q9UIU6 91 7.05e-03 30 3 1 0.333 0.033 TF:M06732_0 tf 1 Factor: ZNF304; motif: GGGGCTTTGCTG; match class: 0 1 Q96FV0 91 7.29e-03 31 3 1 0.333 0.032 TF:M06248_0 tf 1 Factor: ZNF91; motif: NKGTGARAAAGM; match class: 0 1 Q96FV0 91 7.52e-03 32 3 1 0.333 0.031 TF:M06613_0 tf 1 Factor: ZNF514; motif: NGTTGATTMAGM; match class: 0 1 Q96FV0 91 7.53e-03 9 3 1 0.333 0.111 GO:1905332 BP 1 positive regulation of morphogenesis of an epithelium 1 Q9UIU6 91 7.53e-03 9 3 1 0.333 0.111 GO:0061217 BP 1 regulation of mesonephros development 1 Q9UIU6 91 7.53e-03 9 3 1 0.333 0.111 GO:0061213 BP 1 positive regulation of mesonephros development 1 Q9UIU6 91 7.53e-03 9 3 1 0.333 0.111 GO:0021545 BP 1 cranial nerve development 1 Q9UIU6 91 8.37e-03 10 3 1 0.333 0.100 GO:0060037 BP 1 pharyngeal system development 1 Q9UIU6 91 8.37e-03 10 3 1 0.333 0.100 GO:0034497 BP 1 protein localization to pre-autophagosomal structure 1 Q86VP3 91 8.87e-03 1618 3 3 1.000 0.002 GO:0033036 BP 1 macromolecule localization 1 Q9UIU6,Q96FV0,Q86VP3 91 9.21e-03 11 3 1 0.333 0.091 GO:2001014 BP 1 regulation of skeletal muscle cell differentiation 1 Q9UIU6 91 1.06e-02 45 3 1 0.333 0.022 TF:M06556_0 tf 1 Factor: znf383; motif: KGGAAGGTAAGC; match class: 0 1 Q9UIU6 91 1.09e-02 13 3 1 0.333 0.077 GO:0045214 BP 1 sarcomere organization 1 Q9UIU6 91 1.10e-02 47 3 1 0.333 0.021 TF:M00184_1 tf 1 Factor: MyoD; motif: NNCACCTGNY; match class: 1 1 Q86VP3 91 1.17e-02 14 3 1 0.333 0.071 GO:0072171 BP 1 mesonephric tubule morphogenesis 1 Q9UIU6 91 1.17e-02 14 3 1 0.333 0.071 GO:0060675 BP 1 ureteric bud morphogenesis 1 Q9UIU6 91 1.17e-02 14 3 1 0.333 0.071 GO:0001658 BP 1 branching involved in ureteric bud morphogenesis 1 Q9UIU6 91 1.25e-02 15 3 1 0.333 0.067 GO:0035914 BP 1 skeletal muscle cell differentiation 1 Q9UIU6 91 1.25e-02 15 3 1 0.333 0.067 GO:0060688 BP 1 regulation of morphogenesis of a branching structure 1 Q9UIU6 91 1.25e-02 15 3 1 0.333 0.067 GO:0045843 BP 1 negative regulation of striated muscle tissue development 1 Q9UIU6 91 1.25e-02 15 3 1 0.333 0.067 GO:1901862 BP 1 negative regulation of muscle tissue development 1 Q9UIU6 91 1.30e-02 1836 3 3 1.000 0.002 GO:0051641 BP 1 cellular localization 1 Q9UIU6,Q96FV0,Q86VP3 91 1.34e-02 16 3 1 0.333 0.062 GO:0040019 BP 1 positive regulation of embryonic development 1 Q9UIU6 91 1.34e-02 16 3 1 0.333 0.062 GO:0048635 BP 1 negative regulation of muscle organ development 1 Q9UIU6 91 1.40e-02 445 3 2 0.667 0.004 GO:0070925 BP 1 organelle assembly 1 Q9UIU6,Q86VP3 91 1.42e-02 17 3 1 0.333 0.059 GO:0072661 BP 1 protein targeting to plasma membrane 1 Q86VP3 91 1.42e-02 17 3 1 0.333 0.059 GO:0021675 BP 1 nerve development 1 Q9UIU6 91 1.42e-02 17 3 1 0.333 0.059 GO:0090184 BP 1 positive regulation of kidney development 1 Q9UIU6 91 1.42e-02 17 3 1 0.333 0.059 GO:0072078 BP 1 nephron tubule morphogenesis 1 Q9UIU6 91 1.51e-02 18 3 1 0.333 0.056 GO:0072028 BP 1 nephron morphogenesis 1 Q9UIU6 91 1.51e-02 18 3 1 0.333 0.056 GO:0072088 BP 1 nephron epithelium morphogenesis 1 Q9UIU6 91 1.59e-02 19 3 1 0.333 0.053 GO:0048641 BP 1 regulation of skeletal muscle tissue development 1 Q9UIU6 91 1.66e-02 972 3 2 0.667 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q9UIU6,Q86VP3 91 1.67e-02 487 3 2 0.667 0.004 GO:0006605 BP 1 protein targeting 1 Q96FV0,Q86VP3 91 1.67e-02 20 3 1 0.333 0.050 GO:0061053 BP 1 somite development 1 Q9UIU6 91 1.67e-02 20 3 1 0.333 0.050 GO:0061333 BP 1 renal tubule morphogenesis 1 Q9UIU6 91 1.76e-02 21 3 1 0.333 0.048 GO:0001657 BP 1 ureteric bud development 1 Q9UIU6 91 1.80e-02 77 3 1 0.333 0.013 TF:M05715_0 tf 1 Factor: ZNF133; motif: KGGTAAAAAAAA; match class: 0 1 Q9UIU6 91 1.84e-02 22 3 1 0.333 0.045 GO:0090183 BP 1 regulation of kidney development 1 Q9UIU6 91 1.84e-02 22 3 1 0.333 0.045 GO:0072164 BP 1 mesonephric tubule development 1 Q9UIU6 91 1.84e-02 22 3 1 0.333 0.045 GO:0072163 BP 1 mesonephric epithelium development 1 Q9UIU6 91 1.92e-02 23 3 1 0.333 0.043 GO:0060993 BP 1 kidney morphogenesis 1 Q9UIU6 91 1.99e-02 3450 3 3 1.000 0.001 TF:M00750_1 tf 1 Factor: HMGIY; motif: GGAAAWT; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 2.01e-02 24 3 1 0.333 0.042 GO:0001823 BP 1 mesonephros development 1 Q9UIU6 91 2.01e-02 24 3 1 0.333 0.042 GO:0072080 BP 1 nephron tubule development 1 Q9UIU6 91 2.01e-02 24 3 1 0.333 0.042 GO:0046546 BP 1 development of primary male sexual characteristics 1 Q9UIU6 91 2.01e-02 24 3 1 0.333 0.042 GO:0008584 BP 1 male gonad development 1 Q9UIU6 91 2.09e-02 25 3 1 0.333 0.040 GO:0061326 BP 1 renal tubule development 1 Q9UIU6 91 2.13e-02 91 3 1 0.333 0.011 TF:M05748_0 tf 1 Factor: ZNF697; motif: NTGGGCRTCGGC; match class: 0 1 Q86VP3 91 2.16e-02 3548 3 3 1.000 0.001 TF:M00174_0 tf 1 Factor: AP-1; motif: NNTGACTCANN; match class: 0 1 Q9UIU6,Q96FV0,Q86VP3 91 2.17e-02 26 3 1 0.333 0.038 GO:0001656 BP 1 metanephros development 1 Q9UIU6 91 2.17e-02 26 3 1 0.333 0.038 GO:0046661 BP 1 male sex differentiation 1 Q9UIU6 91 2.26e-02 27 3 1 0.333 0.037 GO:0030239 BP 1 myofibril assembly 1 Q9UIU6 91 2.27e-02 3602 3 3 1.000 0.001 TF:M07353_0 tf 1 Factor: E2A; motif: CAGNTGNN; match class: 0 1 Q9UIU6,Q96FV0,Q86VP3 91 2.36e-02 3653 3 3 1.000 0.001 TF:M01247_1 tf 1 Factor: Nanog; motif: NNWNNANAACAAWRGNNNNN; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 2.43e-02 2262 3 3 1.000 0.001 GO:0006996 BP 1 organelle organization 1 Q9UIU6,Q96FV0,Q86VP3 91 2.45e-02 1187 3 2 0.667 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 Q96FV0,Q86VP3 91 2.57e-02 1217 3 2 0.667 0.002 TF:M07226_1 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 1 Q9UIU6,Q86VP3 91 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q86VP3 91 2.69e-02 115 3 1 0.333 0.009 TF:M01588_1 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 1 Q86VP3 91 2.73e-02 1256 3 2 0.667 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 Q96FV0,Q86VP3 91 2.73e-02 117 3 1 0.333 0.009 TF:M06285_0 tf 1 Factor: ZNF124; motif: NGGTACTTGGGA; match class: 0 1 Q86VP3 91 2.76e-02 33 3 1 0.333 0.030 GO:0001838 BP 1 embryonic epithelial tube formation 1 Q9UIU6 91 2.84e-02 34 3 1 0.333 0.029 GO:0072009 BP 1 nephron epithelium development 1 Q9UIU6 91 2.84e-02 34 3 1 0.333 0.029 GO:0072175 BP 1 epithelial tube formation 1 Q9UIU6 91 2.88e-02 3901 3 3 1.000 0.001 TF:M01269_1 tf 1 Factor: NURR1; motif: YRRCCTT; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 3.01e-02 36 3 1 0.333 0.028 GO:0048754 BP 1 branching morphogenesis of an epithelial tube 1 Q9UIU6 91 3.01e-02 657 3 2 0.667 0.003 GO:0033365 BP 1 protein localization to organelle 1 Q9UIU6,Q96FV0 91 3.03e-02 130 3 1 0.333 0.008 TF:M07210_1 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 1 1 Q96FV0 91 3.09e-02 37 3 1 0.333 0.027 GO:0060541 BP 1 respiratory system development 1 Q9UIU6 91 3.09e-02 37 3 1 0.333 0.027 GO:0014902 BP 1 myotube differentiation 1 Q9UIU6 91 3.09e-02 37 3 1 0.333 0.027 GO:0007519 BP 1 skeletal muscle tissue development 1 Q9UIU6 91 3.12e-02 4006 3 3 1.000 0.001 TF:M00792_1 tf 1 Factor: SMAD; motif: AGACNBCNN; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 3.15e-02 135 3 1 0.333 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 Q9UIU6 91 3.17e-02 38 3 1 0.333 0.026 GO:0016331 BP 1 morphogenesis of embryonic epithelium 1 Q9UIU6 91 3.26e-02 39 3 1 0.333 0.026 GO:0061138 BP 1 morphogenesis of a branching epithelium 1 Q9UIU6 91 3.32e-02 1392 3 2 0.667 0.001 TF:M04315_1 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 1 1 Q9UIU6,Q96FV0 91 3.34e-02 40 3 1 0.333 0.025 GO:0060538 BP 1 skeletal muscle organ development 1 Q9UIU6 91 3.34e-02 40 3 1 0.333 0.025 GO:0035148 BP 1 tube formation 1 Q9UIU6 91 3.34e-02 40 3 1 0.333 0.025 GO:0072073 BP 1 kidney epithelium development 1 Q9UIU6 91 3.36e-02 144 3 1 0.333 0.007 TF:M07362_1 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 1 1 Q9UIU6 91 3.38e-02 145 3 1 0.333 0.007 TF:M02377_1 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 1 1 Q96FV0 91 3.42e-02 4131 3 3 1.000 0.001 TF:M07287_0 tf 1 Factor: FOXO3A; motif: NNNRTAAACANNN; match class: 0 1 Q9UIU6,Q96FV0,Q86VP3 91 3.50e-02 709 3 2 0.667 0.003 GO:0006886 BP 1 intracellular protein transport 1 Q96FV0,Q86VP3 91 3.51e-02 42 3 1 0.333 0.024 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 Q9UIU6 91 3.51e-02 42 3 1 0.333 0.024 GO:0008406 BP 1 gonad development 1 Q9UIU6 91 3.56e-02 153 3 1 0.333 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 Q96FV0 91 3.59e-02 43 3 1 0.333 0.023 GO:0045137 BP 1 development of primary sexual characteristics 1 Q9UIU6 91 3.75e-02 45 3 1 0.333 0.022 GO:1901861 BP 1 regulation of muscle tissue development 1 Q9UIU6 91 3.75e-02 45 3 1 0.333 0.022 GO:0055002 BP 1 striated muscle cell development 1 Q9UIU6 91 3.75e-02 45 3 1 0.333 0.022 GO:0001763 BP 1 morphogenesis of a branching structure 1 Q9UIU6 91 3.75e-02 45 3 1 0.333 0.022 GO:0043524 BP 1 negative regulation of neuron apoptotic process 1 Q9UIU6 91 3.75e-02 45 3 1 0.333 0.022 GO:0016202 BP 1 regulation of striated muscle tissue development 1 Q9UIU6 91 3.84e-02 46 3 1 0.333 0.022 GO:0048634 BP 1 regulation of muscle organ development 1 Q9UIU6 91 3.84e-02 165 3 1 0.333 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 Q96FV0 91 3.88e-02 4310 3 3 1.000 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 4.02e-02 173 3 1 0.333 0.006 TF:M07374_0 tf 1 Factor: Bach1; motif: GCTGAGTCAYGNT; match class: 0 1 Q96FV0 91 4.09e-02 49 3 1 0.333 0.020 GO:0045995 BP 1 regulation of embryonic development 1 Q9UIU6 91 4.09e-02 4387 3 3 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 Q9UIU6,Q96FV0,Q86VP3 91 4.25e-02 51 3 1 0.333 0.020 GO:0072006 BP 1 nephron development 1 Q9UIU6 91 4.27e-02 184 3 1 0.333 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 Q96FV0 91 4.50e-02 54 3 1 0.333 0.019 GO:0055001 BP 1 muscle cell development 1 Q9UIU6 91 4.78e-02 4619 3 3 1.000 0.001 TF:M06202_1 tf 1 Factor: ZXDB; motif: NAGGGTG; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 4.78e-02 4619 3 3 1.000 0.001 TF:M06203_1 tf 1 Factor: ZXDA; motif: NAGGGTG; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 4.79e-02 4622 3 3 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 Q9UIU6,Q96FV0,Q86VP3 91 4.83e-02 58 3 1 0.333 0.017 GO:0090596 BP 1 sensory organ morphogenesis 1 Q9UIU6 91 4.91e-02 212 3 1 0.333 0.005 TF:M05770_0 tf 1 Factor: ZNFpT1; motif: GTWTTTTCGA; match class: 0 1 Q86VP3 91 5.00e-02 370 3 2 0.667 0.005 MI:hsa-miR-510 mi 1 MI:hsa-miR-510 1 Q96FV0,Q86VP3 91 5.00e-02 60 3 1 0.333 0.017 GO:0007548 BP 1 sex differentiation 1 Q9UIU6 92 1.77e-04 26 4 2 0.500 0.077 KEGG:00410 keg 1 beta-Alanine metabolism 1 P30837,P80404 92 5.60e-04 46 4 2 0.500 0.043 KEGG:00280 keg 1 Valine, leucine and isoleucine degradation 1 P30837,P80404 92 6.22e-04 324 4 3 0.750 0.009 GO:0005975 BP 1 carbohydrate metabolic process 1 P36871,P30837,Q01415 92 1.02e-03 62 4 2 0.500 0.032 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P36871,P30837 92 2.24e-03 2 4 1 0.250 0.500 REAC:916853 rea 1 Degradation of GABA 1 P80404 92 2.38e-03 2813 4 4 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 P36871,P30837,Q01415,P80404 92 2.51e-03 1 4 1 0.250 1.000 GO:0032144 CC 1 4-aminobutyrate transaminase complex 1 P80404 92 2.51e-03 1 4 1 0.250 1.000 GO:0003867 MF 1 4-aminobutyrate transaminase activity 1 P80404 92 2.51e-03 1 4 1 0.250 1.000 GO:0032145 MF 1 succinate-semialdehyde dehydrogenase binding 1 P80404 92 2.83e-03 9 4 1 0.250 0.111 TF:M04171_1 tf 1 Factor: HES-7; motif: YGGCACGTGCCR; match class: 1 1 Q01415 92 2.83e-03 9 4 1 0.250 0.111 TF:M04171_0 tf 1 Factor: HES-7; motif: YGGCACGTGCCR; match class: 0 1 Q01415 92 3.98e-03 1108 4 3 0.750 0.003 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 P36871,P30837,P80404 92 5.01e-03 2 4 1 0.250 0.500 GO:0004335 MF 1 galactokinase activity 1 Q01415 92 5.01e-03 2 4 1 0.250 0.500 GO:0009450 BP 1 gamma-aminobutyric acid catabolic process 1 P80404 92 5.01e-03 2 4 1 0.250 0.500 GO:0009448 BP 1 gamma-aminobutyric acid metabolic process 1 P80404 92 5.39e-03 3450 4 4 1.000 0.001 TF:M00750_1 tf 1 Factor: HMGIY; motif: GGAAAWT; match class: 1 1 P36871,P30837,Q01415,P80404 92 5.60e-03 5 4 1 0.250 0.200 REAC:70370 rea 1 Galactose catabolism 1 P36871 92 6.89e-03 375 4 2 0.500 0.005 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P36871,P80404 92 7.52e-03 3 4 1 0.250 0.333 GO:0048148 BP 1 behavioral response to cocaine 1 P80404 92 7.52e-03 3 4 1 0.250 0.333 GO:0004614 MF 1 phosphoglucomutase activity 1 P36871 92 7.83e-03 25 4 1 0.250 0.040 TF:M06861_0 tf 1 Factor: ZNF484; motif: NGRTAGGGGAAA; match class: 0 1 P30837 92 8.87e-03 503 4 2 0.500 0.004 TF:M07213_0 tf 1 Factor: GATA2; motif: NNNTTCTTATCTSN; match class: 0 1 P36871,P30837 92 8.96e-03 8 4 1 0.250 0.125 REAC:71384 rea 1 Ethanol oxidation 1 P30837 92 8.96e-03 3917 4 4 1.000 0.001 TF:M04333_0 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 0 1 P36871,P30837,Q01415,P80404 92 1.00e-02 4 4 1 0.250 0.250 GO:0042220 BP 1 response to cocaine 1 P80404 92 1.00e-02 4 4 1 0.250 0.250 GO:0042135 BP 1 neurotransmitter catabolic process 1 P80404 92 1.04e-02 4067 4 4 1.000 0.001 TF:M00346_1 tf 1 Factor: GATA-1; motif: NCWGATAACA; match class: 1 1 P36871,P30837,Q01415,P80404 92 1.05e-02 548 4 2 0.500 0.004 TF:M07291_0 tf 1 Factor: GLI2; motif: TGGGTGGTCNS; match class: 0 1 P30837,P80404 92 1.14e-02 4160 4 4 1.000 0.001 TF:M01722_1 tf 1 Factor: RORbeta; motif: TGACCYA; match class: 1 1 P36871,P30837,Q01415,P80404 92 1.16e-02 508 4 2 0.500 0.004 MI:hsa-miR-451 mi 1 MI:hsa-miR-451 1 P30837,Q01415 92 1.16e-02 1889 4 3 0.750 0.002 TF:M00775_0 tf 1 Factor: NF-Y; motif: NNNNRRCCAATSR; match class: 0 1 P36871,Q01415,P80404 92 1.22e-02 592 4 2 0.500 0.003 TF:M01042_0 tf 1 Factor: GLI1; motif: GACCACCCAV; match class: 0 1 P30837,P80404 92 1.23e-02 11 4 1 0.250 0.091 REAC:888590 rea 1 GABA synthesis, release, reuptake and degradation 1 P80404 92 1.25e-02 1939 4 3 0.750 0.002 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 P36871,P30837,Q01415 92 1.29e-02 610 4 2 0.500 0.003 TF:M03871_0 tf 1 Factor: GLI; motif: MCVNNGACCACCCAV; match class: 0 1 P30837,P80404 92 1.31e-02 42 4 1 0.250 0.024 TF:M04338_0 tf 1 Factor: HNF1B; motif: NRTTAATNATTAACN; match class: 0 1 P30837 92 1.46e-02 2048 4 3 0.750 0.001 TF:M02011_1 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 1 P36871,P30837,Q01415 92 1.48e-02 555 4 2 0.500 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 P36871,P80404 92 1.57e-02 14 4 1 0.250 0.071 REAC:3322077 rea 1 Glycogen synthesis 1 P36871 92 1.57e-02 14 4 1 0.250 0.071 REAC:70221 rea 1 Glycogen breakdown (glycogenolysis) 1 P36871 92 1.59e-02 51 4 1 0.250 0.020 TF:M06454_0 tf 1 Factor: ZNF786; motif: KGGWTYAGGGGA; match class: 0 1 P30837 92 1.62e-02 52 4 1 0.250 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 P30837 92 1.63e-02 689 4 2 0.500 0.003 TF:M01596_0 tf 1 Factor: Gli3; motif: STGGGTGGYCY; match class: 0 1 P30837,P80404 92 1.65e-02 18 4 1 0.250 0.056 KEGG:00340 keg 1 Histidine metabolism 1 P30837 92 1.65e-02 18 4 1 0.250 0.056 KEGG:00650 keg 1 Butanoate metabolism 1 P80404 92 1.67e-02 4 4 1 0.250 0.250 HP:0005305 hp 1 Cerebral venous thrombosis 1 P36871 92 1.73e-02 711 4 2 0.500 0.003 TF:M07136_0 tf 1 Factor: TCF-4; motif: NNASATCAAAGNNN; match class: 0 1 P30837,P80404 92 1.75e-02 7 4 1 0.250 0.143 GO:0019388 BP 1 galactose catabolic process 1 P36871 92 1.84e-02 20 4 1 0.250 0.050 KEGG:00053 keg 1 Ascorbate and aldarate metabolism 1 P30837 92 1.90e-02 61 4 1 0.250 0.016 TF:M01239_1 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 1 1 P80404 92 1.91e-02 246 4 2 0.500 0.008 GO:0044282 BP 1 small molecule catabolic process 1 P36871,P80404 92 2.00e-02 8 4 1 0.250 0.125 GO:0006067 BP 1 ethanol metabolic process 1 P30837 92 2.00e-02 8 4 1 0.250 0.125 GO:0006069 BP 1 ethanol oxidation 1 P30837 92 2.00e-02 8 4 1 0.250 0.125 GO:0006012 BP 1 galactose metabolic process 1 P36871 92 2.09e-02 67 4 1 0.250 0.015 TF:M06487_0 tf 1 Factor: ZNF695; motif: NTKTAAGGAGNT; match class: 0 1 Q01415 92 2.18e-02 802 4 2 0.500 0.002 TF:M03573_1 tf 1 Factor: FKHL5; motif: ATGTTTAT; match class: 1 1 P36871,P80404 92 2.21e-02 71 4 1 0.250 0.014 TF:M04337_0 tf 1 Factor: HNF1B; motif: GTTAATNATTAAY; match class: 0 1 P30837 92 2.23e-02 2013 4 3 0.750 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 P36871,P30837,P80404 92 2.24e-02 72 4 1 0.250 0.014 TF:M01124_1 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1 P36871 92 2.29e-02 25 4 1 0.250 0.040 KEGG:00052 keg 1 Galactose metabolism 1 P36871 92 2.34e-02 75 4 1 0.250 0.013 TF:M06462_0 tf 1 Factor: ZNF441; motif: KGKTCTTGMTSG; match class: 0 1 P30837 92 2.38e-02 26 4 1 0.250 0.038 KEGG:00500 keg 1 Starch and sucrose metabolism 1 P36871 92 2.38e-02 26 4 1 0.250 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 P36871 92 2.43e-02 78 4 1 0.250 0.013 TF:M06741_0 tf 1 Factor: ZNF70; motif: NGGWCAAAAAGM; match class: 0 1 Q01415 92 2.46e-02 854 4 2 0.500 0.002 TF:M07095_0 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 0 1 P36871,P80404 92 2.49e-02 80 4 1 0.250 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 P36871 92 2.50e-02 10 4 1 0.250 0.100 GO:0016868 MF 1 intramolecular transferase activity, phosphotransferases 1 P36871 92 2.58e-02 2498 4 3 0.750 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 P36871,P30837,P80404 92 2.58e-02 2498 4 3 0.750 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 P36871,P30837,P80404 92 2.58e-02 83 4 1 0.250 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 P36871 92 2.66e-02 29 4 1 0.250 0.034 KEGG:00250 keg 1 Alanine, aspartate and glutamate metabolism 1 P80404 92 2.73e-02 2551 4 3 0.750 0.001 TF:M01022_0 tf 1 Factor: LEF-1; motif: NWTCAAAGNN; match class: 0 1 P30837,Q01415,P80404 92 2.75e-02 30 4 1 0.250 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 P30837 92 2.78e-02 2565 4 3 0.750 0.001 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 P30837,Q01415,P80404 92 2.79e-02 911 4 2 0.500 0.002 TF:M01037_0 tf 1 Factor: GLI; motif: NBTGGGTGGTCN; match class: 0 1 P30837,P80404 92 2.84e-02 31 4 1 0.250 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P80404 92 2.85e-02 2588 4 3 0.750 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 P30837,Q01415,P80404 92 2.86e-02 92 4 1 0.250 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 P30837 92 2.92e-02 7 4 1 0.250 0.143 HP:0001976 hp 1 Reduced antithrombin III activity 1 P36871 92 2.96e-02 5282 4 4 1.000 0.001 TF:M00913_0 tf 1 Factor: MYB; motif: NAACNGNCN; match class: 0 1 P36871,P30837,Q01415,P80404 92 3.14e-02 101 4 1 0.250 0.010 TF:M06317_0 tf 1 Factor: ZNF829; motif: KGGGSCARACGC; match class: 0 1 P36871 92 3.17e-02 102 4 1 0.250 0.010 TF:M04336_0 tf 1 Factor: HNF1A; motif: NRTTAATNATTAACN; match class: 0 1 P30837 92 3.19e-02 978 4 2 0.500 0.002 TF:M01239_0 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 0 1 P30837,P80404 92 3.23e-02 104 4 1 0.250 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 P30837 92 3.39e-02 1010 4 2 0.500 0.002 TF:M00727_1 tf 1 Factor: SF-1; motif: TGACCTTG; match class: 1 1 P36871,P80404 92 3.39e-02 1010 4 2 0.500 0.002 TF:M02000_1 tf 1 Factor: ERR3; motif: CAAGGTCA; match class: 1 1 P36871,P80404 92 3.41e-02 5471 4 4 1.000 0.001 TF:M00252_0 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 0 1 P36871,P30837,Q01415,P80404 92 3.42e-02 2762 4 3 0.750 0.001 TF:M04317_1 tf 1 Factor: EN1; motif: TAATTRSNYAATTA; match class: 1 1 P36871,Q01415,P80404 92 3.47e-02 38 4 1 0.250 0.026 KEGG:00071 keg 1 Fatty acid degradation 1 P30837 92 3.47e-02 38 4 1 0.250 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P30837 92 3.50e-02 871 4 2 0.500 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P36871,P80404 92 3.50e-02 1048 4 3 0.750 0.003 KEGG:01100 keg 1 Metabolic pathways 1 P36871,P30837,P80404 92 3.50e-02 14 4 1 0.250 0.071 GO:0042133 BP 1 neurotransmitter metabolic process 1 P80404 92 3.54e-02 114 4 1 0.250 0.009 TF:M06155_0 tf 1 Factor: ZNF135; motif: NGTKGTGWAATC; match class: 0 1 P80404 92 3.58e-02 2808 4 3 0.750 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 P36871,P30837,Q01415 92 3.65e-02 1050 4 2 0.500 0.002 TF:M02004_1 tf 1 Factor: GATA-1; motif: NNNNNWGATARNNNN; match class: 1 1 P36871,P80404 92 3.70e-02 344 4 2 0.500 0.006 GO:0005759 CC 1 mitochondrial matrix 1 P30837,P80404 92 3.76e-02 9 4 1 0.250 0.111 HP:0010988 hp 1 Abnormality of the extrinsic pathway 1 P36871 92 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 P36871,P80404 92 3.89e-02 353 4 2 0.500 0.006 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P36871,P80404 92 3.90e-02 35 4 1 0.250 0.029 REAC:112310 rea 1 Neurotransmitter Release Cycle 1 P80404 92 3.92e-02 43 4 1 0.250 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 P30837 92 3.92e-02 5666 4 4 1.000 0.001 TF:M04321_0 tf 1 Factor: EVX2; motif: NNTNATTANN; match class: 0 1 P36871,P30837,Q01415,P80404 92 3.95e-02 2909 4 3 0.750 0.001 TF:M04435_0 tf 1 Factor: RAX; motif: NNYAATTANN; match class: 0 1 P36871,P30837,Q01415 92 4.07e-02 1333 4 3 0.750 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P36871,P30837,P80404 92 4.15e-02 134 4 1 0.250 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q01415 92 4.18e-02 135 4 1 0.250 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 P30837 92 4.19e-02 46 4 1 0.250 0.022 KEGG:00520 keg 1 Amino sugar and nucleotide sugar metabolism 1 P36871 92 4.25e-02 17 4 1 0.250 0.059 GO:0000272 BP 1 polysaccharide catabolic process 1 P36871 92 4.25e-02 17 4 1 0.250 0.059 GO:0009251 BP 1 glucan catabolic process 1 P36871 92 4.25e-02 17 4 1 0.250 0.059 GO:0008483 MF 1 transaminase activity 1 P80404 92 4.25e-02 17 4 1 0.250 0.059 GO:0044247 BP 1 cellular polysaccharide catabolic process 1 P36871 92 4.25e-02 17 4 1 0.250 0.059 GO:0004029 MF 1 aldehyde dehydrogenase (NAD) activity 1 P30837 92 4.25e-02 17 4 1 0.250 0.059 GO:0005980 BP 1 glycogen catabolic process 1 P36871 92 4.30e-02 139 4 1 0.250 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 P30837 92 4.37e-02 48 4 1 0.250 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 P30837 92 4.38e-02 375 4 2 0.500 0.005 GO:0055114 BP 1 oxidation-reduction process 1 P36871,P30837 92 4.39e-02 142 4 1 0.250 0.007 TF:M07115_0 tf 1 Factor: NF-YB; motif: NNNYNRRCCAATCAG; match class: 0 1 P36871 92 4.51e-02 1176 4 2 0.500 0.002 TF:M01261_0 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 0 1 P36871,P80404 92 4.54e-02 147 4 1 0.250 0.007 TF:M00203_1 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 1 1 P36871 92 4.65e-02 1196 4 2 0.500 0.002 TF:M03846_1 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 1 1 P36871,P80404 92 4.66e-02 5915 4 4 1.000 0.001 TF:M00348_1 tf 1 Factor: GATA-2; motif: NNWGATAASA; match class: 1 1 P36871,P30837,Q01415,P80404 92 4.66e-02 1197 4 2 0.500 0.002 TF:M01125_0 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 0 1 P36871,Q01415 92 4.73e-02 3103 4 3 0.750 0.001 TF:M02075_0 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 0 1 P36871,P30837,P80404 92 4.75e-02 19 4 1 0.250 0.053 GO:0019200 MF 1 carbohydrate kinase activity 1 Q01415 92 4.75e-02 19 4 1 0.250 0.053 GO:0016769 MF 1 transferase activity, transferring nitrogenous groups 1 P80404 92 4.75e-02 154 4 1 0.250 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 Q01415 92 4.83e-02 5967 4 4 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 P36871,P30837,Q01415,P80404 92 4.97e-02 161 4 1 0.250 0.006 TF:M07361_1 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 1 1 P80404 92 5.00e-02 1 4 1 0.250 1.000 OMIM:613163 omi 1 GABA-TRANSAMINASE DEFICIENCY 1 P80404 92 5.00e-02 55 4 1 0.250 0.018 KEGG:00310 keg 1 Lysine degradation 1 P30837 92 5.00e-02 20 4 1 0.250 0.050 GO:0034308 BP 1 primary alcohol metabolic process 1 P30837 92 5.00e-02 45 4 1 0.250 0.022 REAC:211945 rea 1 Phase 1 - Functionalization of compounds 1 P30837 92 5.00e-02 12 4 1 0.250 0.083 HP:0000201 hp 1 Pierre-Robin sequence 1 P36871 92 5.00e-02 1 4 1 0.250 1.000 OMIM:614921 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE It; CDG1T;;CDG It; CDGIt;;PHOSPHOGLUCOMUTASE 1 DEFICIENCY;;PGM1 DEFICIENCY;;GLYCOGEN STORAGE DISEASE XIV; GSD14;;GSD XIV 1 P36871 93 4.18e-03 1 3 1 0.333 1.000 OMIM:616340 omi 1 DEAFNESS, AUTOSOMAL DOMINANT 67; DFNA67 1 Q9H1P3 93 6.94e-03 1079 3 3 1.000 0.003 TF:M07267_1 tf 1 Factor: SF-1; motif: TGRCCTTGR; match class: 1 1 Q9H1P3,Q9H3U1,Q92870 93 1.57e-02 802 3 2 0.667 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q9H1P3,Q9H3U1 93 1.61e-02 6 3 1 0.333 0.167 TF:M07213_1 tf 1 Factor: GATA2; motif: NNNTTCTTATCTSN; match class: 1 1 Q92870 93 2.67e-02 1690 3 3 1.000 0.002 TF:M03802_1 tf 1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 1 Q9H1P3,Q9H3U1,Q92870 93 2.84e-02 3293 3 3 1.000 0.001 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 Q9H1P3,Q9H3U1,Q92870 93 3.00e-02 1757 3 3 1.000 0.002 TF:M02056_1 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 1 Q9H1P3,Q9H3U1,Q92870 93 3.04e-02 1765 3 3 1.000 0.002 TF:M00280_1 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 1 1 Q9H1P3,Q9H3U1,Q92870 93 3.47e-02 3521 3 3 1.000 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q9H1P3,Q9H3U1,Q92870 93 3.54e-02 1220 3 2 0.667 0.002 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 Q9H1P3,Q92870 93 4.03e-02 15 3 1 0.333 0.067 TF:M05745_0 tf 1 Factor: ZNF718; motif: NGGGRATWGCGM; match class: 0 1 Q9H3U1 93 4.15e-02 29 3 1 0.333 0.034 HP:0005102 hp 1 Cochlear degeneration 1 Q9H1P3 93 4.15e-02 29 3 1 0.333 0.034 HP:0008615 hp 1 Adult onset sensorineural hearing impairment 1 Q9H1P3 93 4.15e-02 29 3 1 0.333 0.034 HP:0008542 hp 1 Low-frequency hearing loss 1 Q9H1P3 93 4.15e-02 29 3 1 0.333 0.034 HP:0008573 hp 1 Low-frequency sensorineural hearing impairment 1 Q9H1P3 93 4.15e-02 29 3 1 0.333 0.034 HP:0040113 hp 1 Old-aged sensorineural hearing impairment 1 Q9H1P3 93 4.29e-02 24 3 1 0.333 0.042 REAC:192105 rea 1 Synthesis of bile acids and bile salts 1 Q9H1P3 93 4.29e-02 30 3 1 0.333 0.033 HP:0008596 hp 1 Postlingual sensorineural hearing impairment 1 Q9H1P3 93 4.29e-02 30 3 1 0.333 0.033 HP:0001963 hp 1 Abnormal speech discrimination 1 Q9H1P3 93 4.57e-02 17 3 1 0.333 0.059 TF:M05887_0 tf 1 Factor: ZNF837; motif: KGGGWAGGCCGC; match class: 0 1 Q9H1P3 93 4.72e-02 33 3 1 0.333 0.030 HP:0005101 hp 1 High-frequency hearing impairment 1 Q9H1P3 93 5.00e-02 12 3 1 0.333 0.083 OMIM:104300 omi 1 Alzheimer Disease 1 Q92870 93 5.00e-02 35 3 1 0.333 0.029 HP:0009591 hp 1 Abnormality of the vestibulocochlear nerve 1 Q9H1P3 93 5.00e-02 2083 3 3 1.000 0.001 TF:M01871_0 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 0 1 Q9H1P3,Q9H3U1,Q92870 93 5.00e-02 28 3 1 0.333 0.036 REAC:194068 rea 1 Bile acid and bile salt metabolism 1 Q9H1P3 93 5.00e-02 18 3 1 0.333 0.056 GO:0001540 MF 1 beta-amyloid binding 1 Q92870 94 4.84e-03 3 2 1 0.500 0.333 GO:0071008 CC 1 U2-type post-mRNA release spliceosomal complex 1 O43143 94 6.46e-03 4 2 1 0.500 0.250 GO:2001137 BP 1 positive regulation of endocytic recycling 1 Q9NZN4 94 8.07e-03 5 2 1 0.500 0.200 GO:1901741 BP 1 positive regulation of myoblast fusion 1 Q9NZN4 94 9.09e-03 58 2 1 0.500 0.017 TF:M06719_1 tf 1 Factor: ZNF430; motif: NCGTAMAAAAGA; match class: 1 1 O43143 94 9.69e-03 6 2 1 0.500 0.167 GO:2001135 BP 1 regulation of endocytic recycling 1 Q9NZN4 94 9.69e-03 6 2 1 0.500 0.167 GO:1901739 BP 1 regulation of myoblast fusion 1 Q9NZN4 94 9.72e-03 62 2 1 0.500 0.016 TF:M06179_0 tf 1 Factor: ZNF445; motif: NGGATAAAGGA; match class: 0 1 O43143 94 1.00e-02 1276 2 2 1.000 0.002 TF:M00136_0 tf 1 Factor: Oct-1; motif: NNGAATATKCANNNN; match class: 0 1 Q9NZN4,O43143 94 1.05e-02 67 2 1 0.500 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 O43143 94 1.13e-02 7 2 1 0.500 0.143 GO:0060143 BP 1 positive regulation of syncytium formation by plasma membrane fusion 1 Q9NZN4 94 1.13e-02 7 2 1 0.500 0.143 GO:0071014 CC 1 post-mRNA release spliceosomal complex 1 O43143 94 1.28e-02 1442 2 2 1.000 0.001 TF:M04470_0 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 0 1 Q9NZN4,O43143 94 1.29e-02 8 2 1 0.500 0.125 GO:0060142 BP 1 regulation of syncytium formation by plasma membrane fusion 1 Q9NZN4 94 1.39e-02 1502 2 2 1.000 0.001 TF:M01783_0 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 0 1 Q9NZN4,O43143 94 1.45e-02 9 2 1 0.500 0.111 GO:0010831 BP 1 positive regulation of myotube differentiation 1 Q9NZN4 94 1.49e-02 1554 2 2 1.000 0.001 TF:M04012_0 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 0 1 Q9NZN4,O43143 94 1.55e-02 99 2 1 0.500 0.010 TF:M01236_0 tf 1 Factor: ipf1; motif: CATTAATMGG; match class: 0 1 O43143 94 1.57e-02 100 2 1 0.500 0.010 TF:M06541_0 tf 1 Factor: ZNF502; motif: NGKTAGGRAATC; match class: 0 1 O43143 94 1.67e-02 107 2 1 0.500 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 O43143 94 1.78e-02 11 2 1 0.500 0.091 GO:0007520 BP 1 myoblast fusion 1 Q9NZN4 94 1.80e-02 1709 2 2 1.000 0.001 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q9NZN4,O43143 94 1.86e-02 119 2 1 0.500 0.008 TF:M04470_1 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 1 1 O43143 94 1.91e-02 1761 2 2 1.000 0.001 TF:M04437_1 tf 1 Factor: RHOXF1; motif: NTRATCCN; match class: 1 1 Q9NZN4,O43143 94 2.26e-02 14 2 1 0.500 0.071 GO:0000768 BP 1 syncytium formation by plasma membrane fusion 1 Q9NZN4 94 2.26e-02 14 2 1 0.500 0.071 GO:0006949 BP 1 syncytium formation 1 Q9NZN4 94 2.27e-02 1920 2 2 1.000 0.001 TF:M00145_0 tf 1 Factor: Brn-2; motif: NNCATNSRWAATNMRN; match class: 0 1 Q9NZN4,O43143 94 2.42e-02 15 2 1 0.500 0.067 GO:0097320 BP 1 membrane tubulation 1 Q9NZN4 94 2.58e-02 16 2 1 0.500 0.062 GO:0051155 BP 1 positive regulation of striated muscle cell differentiation 1 Q9NZN4 94 2.61e-02 2057 2 2 1.000 0.001 TF:M00482_0 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 0 1 Q9NZN4,O43143 94 3.10e-02 199 2 1 0.500 0.005 TF:M06027_0 tf 1 Factor: ZNF891; motif: NNMACAAGGCAA; match class: 0 1 Q9NZN4 94 3.21e-02 117 2 1 0.500 0.009 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 Q9NZN4 94 3.23e-02 20 2 1 0.500 0.050 GO:0055038 CC 1 recycling endosome membrane 1 Q9NZN4 94 3.27e-02 210 2 1 0.500 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 O43143 94 3.35e-02 2330 2 2 1.000 0.001 TF:M07141_0 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 0 1 Q9NZN4,O43143 94 3.55e-02 22 2 1 0.500 0.045 GO:0010830 BP 1 regulation of myotube differentiation 1 Q9NZN4 94 3.60e-02 231 2 1 0.500 0.004 TF:M05479_0 tf 1 Factor: znf580; motif: NGGGCGGTGTS; match class: 0 1 Q9NZN4 94 3.71e-02 2451 2 2 1.000 0.001 TF:M00076_1 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 1 1 Q9NZN4,O43143 94 3.87e-02 24 2 1 0.500 0.042 GO:0005689 CC 1 U12-type spliceosomal complex 1 O43143 94 4.07e-02 262 2 1 0.500 0.004 TF:M06077_0 tf 1 Factor: ZNF716; motif: NCAGGCARAWCC; match class: 0 1 O43143 94 4.19e-02 26 2 1 0.500 0.038 GO:0032456 BP 1 endocytic recycling 1 Q9NZN4 94 4.24e-02 2622 2 2 1.000 0.001 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 Q9NZN4,O43143 94 4.24e-02 273 2 1 0.500 0.004 TF:M05501_0 tf 1 Factor: ZBTB8B; motif: NRGGGGATAGN; match class: 0 1 Q9NZN4 94 4.25e-02 2625 2 2 1.000 0.001 TF:M00706_1 tf 1 Factor: TFII-I; motif: RGAGGKAGG; match class: 1 1 Q9NZN4,O43143 94 4.33e-02 2649 2 2 1.000 0.001 TF:M04632_1 tf 1 Factor: SREBP-1; motif: NNNGTGGGGTGAN; match class: 1 1 Q9NZN4,O43143 94 4.35e-02 20 2 1 0.500 0.050 CORUM:1332 cor 1 Large Drosha complex 1 O43143 94 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 O43143 94 4.58e-02 2724 2 2 1.000 0.001 TF:M04134_0 tf 1 Factor: TBX2; motif: NAGGTGTGAAN; match class: 0 1 Q9NZN4,O43143 94 4.73e-02 173 2 1 0.500 0.006 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 O43143 94 4.77e-02 307 2 1 0.500 0.003 TF:M01816_1 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 1 O43143 94 4.92e-02 180 2 1 0.500 0.006 REAC:72172 rea 1 mRNA Splicing 1 O43143 94 5.00e-02 128 2 1 0.500 0.008 KEGG:03040 keg 1 Spliceosome 1 O43143 94 5.00e-02 31 2 1 0.500 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 O43143 94 5.00e-02 23 2 1 0.500 0.043 CORUM:430 cor 1 18S U11/U12 snRNP 1 O43143 95 7.82e-46 31 27 19 0.704 0.613 GO:0006409 BP 1 tRNA export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.82e-46 31 27 19 0.704 0.613 GO:0071431 BP 1 tRNA-containing ribonucleoprotein complex export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.47e-45 32 27 20 0.741 0.625 REAC:159227 rea 1 Transport of the SLBP independent Mature mRNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 4.53e-45 33 27 19 0.704 0.576 GO:0051031 BP 1 tRNA transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.13e-44 33 27 20 0.741 0.606 REAC:159230 rea 1 Transport of the SLBP Dependant Mature mRNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.82e-44 61 27 21 0.778 0.344 GO:0005643 CC 1 nuclear pore 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,P49792,Q92621,Q8NFH5,O14715 95 3.14e-43 37 27 20 0.741 0.541 REAC:159231 rea 1 Transport of Mature mRNA Derived from an Intronless Transcript 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 6.61e-43 38 27 20 0.741 0.526 REAC:159234 rea 1 Transport of Mature mRNAs Derived from Intronless Transcripts 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 9.74e-43 30 27 19 0.704 0.633 REAC:168271 rea 1 Transport of Ribonucleoproteins into the Host Nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.74e-43 30 27 19 0.704 0.633 REAC:170822 rea 1 Regulation of Glucokinase by Glucokinase Regulatory Protein 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.74e-43 30 27 19 0.704 0.633 REAC:168333 rea 1 NEP/NS2 Interacts with the Cellular Export Machinery 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.74e-43 30 27 19 0.704 0.633 REAC:168274 rea 1 Export of Viral Ribonucleoproteins from Nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.46e-42 42 27 19 0.704 0.452 GO:0007077 BP 1 mitotic nuclear envelope disassembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.18e-42 32 27 19 0.704 0.594 REAC:180746 rea 1 Nuclear import of Rev protein 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.18e-42 32 27 19 0.704 0.594 REAC:180910 rea 1 Vpr-mediated nuclear import of PICs 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.74e-42 44 27 19 0.704 0.432 GO:0030397 BP 1 membrane disassembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.74e-42 44 27 19 0.704 0.432 GO:0051081 BP 1 nuclear envelope disassembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.46e-41 33 27 19 0.704 0.576 REAC:165054 rea 1 Rev-mediated nuclear export of HIV RNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.30e-41 34 27 19 0.704 0.559 REAC:3301854 rea 1 Nuclear Pore Complex (NPC) Disassembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.45e-41 44 27 20 0.741 0.455 REAC:4615885 rea 1 SUMOylation of DNA replication proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.20e-41 45 27 20 0.741 0.444 REAC:4570464 rea 1 SUMOylation of RNA binding proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.20e-41 35 27 19 0.704 0.543 REAC:176033 rea 1 Interactions of Vpr with host cellular proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.20e-41 35 27 19 0.704 0.543 REAC:177243 rea 1 Interactions of Rev with host cellular proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.22e-39 39 27 19 0.704 0.487 REAC:70153 rea 1 Glucose transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.22e-39 39 27 19 0.704 0.487 REAC:168276 rea 1 NS1 Mediated Effects on Host Pathways 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.31e-39 41 27 19 0.704 0.463 REAC:168253 rea 1 Host Interactions with Influenza Factors 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.63e-39 100 27 21 0.778 0.210 GO:0006406 BP 1 mRNA export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 4.63e-39 100 27 21 0.778 0.210 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 5.16e-39 58 27 19 0.704 0.328 GO:0010827 BP 1 regulation of glucose transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.87e-39 42 27 19 0.704 0.452 REAC:168325 rea 1 Viral Messenger RNA Synthesis 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.16e-38 104 27 21 0.778 0.202 GO:0051028 BP 1 mRNA transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.41e-38 43 27 19 0.704 0.442 REAC:189200 rea 1 Hexose transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.24e-38 111 27 21 0.778 0.189 GO:0006405 BP 1 RNA export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 6.44e-38 112 27 21 0.778 0.188 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 6.68e-38 65 27 19 0.704 0.292 GO:0075733 BP 1 intracellular transport of virus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.37e-38 66 27 19 0.704 0.288 GO:1902581 BP 1 multi-organism cellular localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.37e-38 66 27 19 0.704 0.288 GO:1902583 BP 1 multi-organism intracellular transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.18e-37 115 27 21 0.778 0.183 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.31e-37 67 27 19 0.704 0.284 GO:0046794 BP 1 transport of virus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.81e-37 68 27 19 0.704 0.279 GO:0006998 BP 1 nuclear envelope organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.43e-37 70 27 19 0.704 0.271 GO:1902579 BP 1 multi-organism localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.43e-37 70 27 19 0.704 0.271 GO:0044766 BP 1 multi-organism transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.31e-37 50 27 19 0.704 0.380 REAC:2980766 rea 1 Nuclear Envelope Breakdown 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.31e-37 50 27 19 0.704 0.380 REAC:194441 rea 1 Metabolism of non-coding RNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.31e-37 50 27 19 0.704 0.380 REAC:191859 rea 1 snRNP Assembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 8.01e-37 125 27 21 0.778 0.168 GO:0050657 BP 1 nucleic acid transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 8.01e-37 125 27 21 0.778 0.168 GO:0050658 BP 1 RNA transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 8.58e-37 73 27 19 0.704 0.260 GO:1900034 BP 1 regulation of cellular response to heat 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.38e-36 128 27 21 0.778 0.164 GO:0051236 BP 1 establishment of RNA localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.57e-36 68 27 20 0.741 0.294 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 3.61e-36 78 27 19 0.704 0.244 GO:0015758 BP 1 glucose transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.61e-36 78 27 19 0.704 0.244 GO:0008645 BP 1 hexose transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.74e-36 79 27 19 0.704 0.241 GO:0015749 BP 1 monosaccharide transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.87e-36 55 27 19 0.704 0.345 REAC:6784531 rea 1 tRNA processing in the nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.37e-35 83 27 19 0.704 0.229 GO:0008643 BP 1 carbohydrate transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.45e-35 142 27 21 0.778 0.148 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.53e-35 75 27 20 0.741 0.267 REAC:3108214 rea 1 SUMOylation of DNA damage response and repair proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.53e-35 75 27 20 0.741 0.267 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.27e-35 85 27 19 0.704 0.224 GO:0034605 BP 1 cellular response to heat 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.42e-35 59 27 19 0.704 0.322 REAC:5578749 rea 1 Transcriptional regulation by small RNAs 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.75e-35 153 27 21 0.778 0.137 GO:0051168 BP 1 nuclear export 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.08e-34 120 27 20 0.741 0.167 GO:0016925 BP 1 protein sumoylation 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.59e-34 158 27 21 0.778 0.133 GO:0006403 BP 1 RNA localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.97e-34 66 27 19 0.704 0.288 REAC:1169410 rea 1 Antiviral mechanism by IFN-stimulated genes 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.97e-34 66 27 19 0.704 0.288 REAC:1169408 rea 1 ISG15 antiviral mechanism 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.01e-34 100 27 19 0.704 0.190 GO:0009408 BP 1 response to heat 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.30e-33 103 27 19 0.704 0.184 GO:0006997 BP 1 nucleus organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.88e-33 75 27 19 0.704 0.253 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.08e-33 110 27 19 0.704 0.173 GO:0031047 BP 1 gene silencing by RNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.98e-33 99 27 20 0.741 0.202 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.25e-32 244 27 22 0.815 0.090 GO:0005635 CC 1 nuclear envelope 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,O14715 95 2.57e-32 119 27 19 0.704 0.160 GO:0009266 BP 1 response to temperature stimulus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.92e-32 105 27 20 0.741 0.190 REAC:2990846 rea 1 SUMOylation 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.18e-32 86 27 19 0.704 0.221 REAC:211000 rea 1 Gene Silencing by RNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.03e-31 91 27 19 0.704 0.209 REAC:3371556 rea 1 Cellular response to heat stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.79e-31 93 27 19 0.704 0.204 REAC:68875 rea 1 Mitotic Prophase 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.70e-29 164 27 19 0.704 0.116 GO:0019083 BP 1 viral transcription 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.92e-29 165 27 19 0.704 0.115 GO:0016458 BP 1 gene silencing 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.75e-29 113 27 19 0.704 0.168 REAC:72306 rea 1 tRNA processing 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.84e-29 148 27 20 0.741 0.135 REAC:913531 rea 1 Interferon Signaling 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.23e-29 175 27 19 0.704 0.109 GO:0019080 BP 1 viral gene expression 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.18e-28 125 27 19 0.704 0.152 REAC:162909 rea 1 Host Interactions of HIV factors 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.13e-28 129 27 19 0.704 0.147 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.36e-28 193 27 19 0.704 0.098 GO:0044033 BP 1 multi-organism metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.59e-28 132 27 19 0.704 0.144 REAC:168273 rea 1 Influenza Viral RNA Transcription and Replication 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.20e-28 318 27 21 0.778 0.066 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.08e-27 324 27 21 0.778 0.065 GO:0051169 BP 1 nuclear transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.17e-27 140 27 19 0.704 0.136 REAC:168255 rea 1 Influenza Life Cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.17e-27 140 27 19 0.704 0.136 REAC:162587 rea 1 HIV Life Cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.94e-27 151 27 19 0.704 0.126 REAC:168254 rea 1 Influenza Infection 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.88e-26 296 27 20 0.741 0.068 GO:0018205 BP 1 peptidyl-lysine modification 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.34e-26 374 27 21 0.778 0.056 GO:0071705 BP 1 nitrogen compound transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 3.31e-25 180 27 19 0.704 0.106 REAC:425407 rea 1 SLC-mediated transmembrane transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.14e-25 228 27 20 0.741 0.088 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 6.75e-24 15 27 10 0.370 0.667 GO:0017056 MF 1 structural constituent of nuclear pore 1 Q9BTX1,Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,Q92621 95 1.58e-23 219 27 19 0.704 0.087 REAC:162906 rea 1 HIV Infection 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.94e-23 341 27 19 0.704 0.056 GO:0019058 BP 1 viral life cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.09e-23 426 27 20 0.741 0.047 GO:0022411 BP 1 cellular component disassembly 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.40e-23 665 27 22 0.815 0.033 GO:0031967 CC 1 organelle envelope 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,O14715 95 8.17e-23 668 27 22 0.815 0.033 GO:0031975 CC 1 envelope 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,O14715 95 1.53e-22 246 27 19 0.704 0.077 REAC:71387 rea 1 Metabolism of carbohydrates 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.66e-22 373 27 19 0.704 0.051 GO:0016032 BP 1 viral process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.83e-22 375 27 19 0.704 0.051 GO:0044764 BP 1 multi-organism cellular process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.63e-22 253 27 19 0.704 0.075 REAC:68886 rea 1 M Phase 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.20e-22 386 27 19 0.704 0.049 GO:0044419 BP 1 interspecies interaction between organisms 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.20e-22 386 27 19 0.704 0.049 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.66e-22 404 27 19 0.704 0.047 GO:0010256 BP 1 endomembrane system organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.66e-22 404 27 19 0.704 0.047 GO:0080135 BP 1 regulation of cellular response to stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.88e-21 14 27 9 0.333 0.643 GO:0006999 BP 1 nuclear pore organization 1 Q9BTX1,Q8WUM0,Q96EE3,Q8N1F7,P52948,P57740,P49790,Q92621,Q8NFH5 95 1.20e-20 573 27 20 0.741 0.035 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.95e-20 10 27 8 0.296 0.800 GO:0031080 CC 1 nuclear pore outer ring 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 9.10e-20 519 27 19 0.704 0.037 GO:0009628 BP 1 response to abiotic stimulus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.10e-19 346 27 19 0.704 0.055 REAC:5663205 rea 1 Infectious disease 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.13e-19 662 27 20 0.741 0.030 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.45e-19 446 27 20 0.741 0.045 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.96e-19 378 27 19 0.704 0.050 REAC:2262752 rea 1 Cellular responses to stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.13e-19 574 27 19 0.704 0.033 GO:1902582 BP 1 single-organism intracellular transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.13e-18 720 27 20 0.741 0.028 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.55e-18 630 27 19 0.704 0.030 GO:0044802 BP 1 single-organism membrane organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.40e-18 650 27 19 0.704 0.029 GO:0051704 BP 1 multi-organism process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.83e-18 657 27 19 0.704 0.029 GO:1903047 BP 1 mitotic cell cycle process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.28e-17 814 27 20 0.741 0.025 GO:0080134 BP 1 regulation of response to stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.50e-17 448 27 19 0.704 0.042 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.01e-17 547 27 20 0.741 0.037 REAC:1640170 rea 1 Cell Cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.86e-17 861 27 20 0.741 0.023 GO:0010629 BP 1 negative regulation of gene expression 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.48e-17 721 27 19 0.704 0.026 GO:0000278 BP 1 mitotic cell cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.09e-17 493 27 19 0.704 0.039 REAC:382551 rea 1 Transmembrane transport of small molecules 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.15e-17 749 27 19 0.704 0.025 GO:0061024 BP 1 membrane organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.57e-16 771 27 19 0.704 0.025 GO:1902580 BP 1 single-organism cellular localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.00e-16 936 27 20 0.741 0.021 GO:0051049 BP 1 regulation of transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.79e-15 1237 27 21 0.778 0.017 GO:0046907 BP 1 intracellular transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.21e-15 9 27 8 0.296 0.889 CORUM:87 cor 1 Nup 107-160 subcomplex 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 3.60e-15 712 27 20 0.741 0.028 REAC:597592 rea 1 Post-translational protein modification 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.93e-15 952 27 19 0.704 0.020 GO:0022402 BP 1 cell cycle process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.60e-14 1377 27 21 0.778 0.015 GO:0071702 BP 1 organic substance transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.84e-14 1618 27 22 0.815 0.014 GO:0033036 BP 1 macromolecule localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 3.08e-14 1212 27 20 0.741 0.017 GO:0033554 BP 1 cellular response to stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.32e-14 147 27 11 0.407 0.075 GO:0031965 CC 1 nuclear membrane 1 Q9BTX1,Q8WUM0,Q9NRG9,Q8N1F7,P52948,P57740,P63165,P49790,P49792,Q92621,Q8NFH5 95 4.49e-14 2260 27 24 0.889 0.011 GO:0012505 CC 1 endomembrane system 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5,O14715 95 5.81e-14 10 27 6 0.222 0.600 GO:0051292 BP 1 nuclear pore complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P49790,Q92621 95 8.30e-14 1493 27 21 0.778 0.014 GO:0051649 BP 1 establishment of localization in cell 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.05e-13 720 27 19 0.704 0.026 REAC:1643685 rea 1 Disease 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.21e-13 23 27 7 0.259 0.304 GO:0005487 MF 1 nucleocytoplasmic transporter activity 1 Q12769,Q8WUM0,P52948,P57740,P49790,O15504,Q8NFH5 95 1.38e-13 167 27 11 0.407 0.066 GO:1902593 BP 1 single-organism nuclear import 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 1.38e-13 167 27 11 0.407 0.066 GO:0044744 BP 1 protein targeting to nucleus 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 1.38e-13 167 27 11 0.407 0.066 GO:0006606 BP 1 protein import into nucleus 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 1.54e-13 1317 27 20 0.741 0.015 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.81e-13 1128 27 19 0.704 0.017 GO:0007049 BP 1 cell cycle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.15e-13 1340 27 20 0.741 0.015 GO:0032879 BP 1 regulation of localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.55e-13 12 27 6 0.222 0.500 GO:0046931 BP 1 pore complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P49790,Q92621 95 4.04e-13 184 27 11 0.407 0.060 GO:0051170 BP 1 nuclear import 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 6.91e-13 1424 27 20 0.741 0.014 GO:0009892 BP 1 negative regulation of metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.57e-12 208 27 11 0.407 0.053 GO:0017038 BP 1 protein import 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 1.83e-12 1498 27 20 0.741 0.013 GO:0044765 BP 1 single-organism transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.05e-12 221 27 11 0.407 0.050 GO:0034504 BP 1 protein localization to nucleus 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 4.48e-12 2096 27 22 0.815 0.010 GO:0043234 CC 1 protein complex 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,P49792,Q92621,Q9UBU9,Q8NFH5,O14715 95 5.39e-12 1836 27 21 0.778 0.011 GO:0051641 BP 1 cellular localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 9.50e-12 116 27 9 0.333 0.078 GO:0007062 BP 1 sister chromatid cohesion 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.18e-11 1652 27 20 0.741 0.012 GO:1902578 BP 1 single-organism localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 5.02e-11 1169 27 20 0.741 0.017 REAC:392499 rea 1 Metabolism of proteins 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.11e-11 99 27 9 0.333 0.091 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 6.62e-11 91 27 8 0.296 0.088 GO:0000776 CC 1 kinetochore 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 1.15e-10 3168 27 24 0.889 0.008 GO:0044428 CC 1 nuclear part 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 1.24e-10 107 27 9 0.333 0.084 REAC:68877 rea 1 Mitotic Prometaphase 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.55e-10 2173 27 21 0.778 0.010 GO:0010468 BP 1 regulation of gene expression 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.04e-10 113 27 9 0.333 0.080 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 3.61e-10 1980 27 20 0.741 0.010 GO:0032774 BP 1 RNA biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.66e-10 1485 27 21 0.778 0.014 REAC:74160 rea 1 Gene Expression 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 3.82e-10 2275 27 21 0.778 0.009 GO:0006464 BP 1 cellular protein modification process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 3.82e-10 2275 27 21 0.778 0.009 GO:0036211 BP 1 protein modification process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 5.72e-10 2644 27 22 0.815 0.008 GO:0006810 BP 1 transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 6.70e-10 121 27 8 0.296 0.066 GO:0000775 CC 1 chromosome, centromeric region 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 8.36e-10 2071 27 20 0.741 0.010 GO:0006950 BP 1 response to stress 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.31e-10 2707 27 22 0.815 0.008 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 1.09e-09 196 27 9 0.333 0.046 GO:0000819 BP 1 sister chromatid segregation 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.09e-09 2101 27 20 0.741 0.010 GO:0048583 BP 1 regulation of response to stimulus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.09e-09 6 27 4 0.148 0.667 GO:0000972 BP 1 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery 1 Q8WUM0,P52948,P57740,O75694 95 1.26e-09 2417 27 21 0.778 0.009 GO:0043412 BP 1 macromolecule modification 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 1.27e-09 2748 27 22 0.815 0.008 GO:0051234 BP 1 establishment of localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 2.55e-09 7 27 4 0.148 0.571 GO:0044615 CC 1 nuclear pore nuclear basket 1 P52948,P49790,P49792,Q8NFH5 95 3.08e-09 1457 27 20 0.741 0.014 REAC:168256 rea 1 Immune System 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.85e-09 226 27 9 0.333 0.040 GO:0098813 BP 1 nuclear chromosome segregation 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 4.48e-09 2267 27 20 0.741 0.009 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.89e-09 161 27 9 0.333 0.056 REAC:2467813 rea 1 Separation of Sister Chromatids 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 6.09e-09 2305 27 20 0.741 0.009 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.34e-09 2310 27 20 0.741 0.009 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 7.18e-09 2990 27 22 0.815 0.007 GO:0044267 BP 1 cellular protein metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 8.78e-09 172 27 9 0.333 0.052 REAC:68882 rea 1 Mitotic Anaphase 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 9.24e-09 173 27 9 0.333 0.052 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.05e-08 2374 27 20 0.741 0.008 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.14e-08 3058 27 22 0.815 0.007 GO:0010467 BP 1 gene expression 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.17e-08 3063 27 22 0.815 0.007 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 1.41e-08 485 27 11 0.407 0.023 GO:0072594 BP 1 establishment of protein localization to organelle 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 1.46e-08 263 27 9 0.333 0.034 GO:0007059 BP 1 chromosome segregation 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.47e-08 487 27 11 0.407 0.023 GO:0006605 BP 1 protein targeting 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 2.60e-08 3185 27 22 0.815 0.007 GO:0019538 BP 1 protein metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 3.23e-08 4 27 4 0.148 1.000 CORUM:1347 cor 1 NPC subcomplex (NUP98, NUP107, NUP133, NUP160) 1 Q12769,Q8WUM0,P52948,P57740 95 3.50e-08 2869 27 21 0.778 0.007 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 3.51e-08 3 27 3 0.111 1.000 GO:0044611 CC 1 nuclear pore inner ring 1 Q5SRE5,O75694,Q92621 95 3.51e-08 3 27 3 0.111 1.000 GO:0044614 CC 1 nuclear pore cytoplasmic filaments 1 P52948,Q53GS7,P49792 95 4.24e-08 3263 27 22 0.815 0.007 GO:0019222 BP 1 regulation of metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 4.52e-08 2262 27 19 0.704 0.008 GO:0006996 BP 1 organelle organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.77e-08 414 27 10 0.370 0.024 GO:0005198 MF 1 structural molecule activity 1 Q9BTX1,Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,Q92621 95 6.02e-08 709 27 12 0.444 0.017 GO:0006886 BP 1 intracellular protein transport 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 6.26e-08 2618 27 20 0.741 0.008 GO:0048519 BP 1 negative regulation of biological process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 6.26e-08 1718 27 20 0.741 0.012 REAC:1430728 rea 1 Metabolism 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 6.66e-08 2627 27 20 0.741 0.008 GO:0016070 BP 1 RNA metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 9.69e-08 446 27 10 0.370 0.022 GO:0051276 BP 1 chromosome organization 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,O75694,Q8NFH3,Q9BW27,P49792 95 9.78e-08 3401 27 22 0.815 0.006 GO:0051179 BP 1 localization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5 95 1.01e-07 1111 27 14 0.519 0.013 GO:0034613 BP 1 cellular protein localization 1 Q9BTX1,Q8WUM0,Q96EE3,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 1.06e-07 3415 27 22 0.815 0.006 GO:0032991 CC 1 macromolecular complex 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,P49792,Q92621,Q9UBU9,Q8NFH5,O14715 95 1.09e-07 230 27 8 0.296 0.035 GO:0098687 CC 1 chromosomal region 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 1.13e-07 1121 27 14 0.519 0.012 GO:0070727 BP 1 cellular macromolecule localization 1 Q9BTX1,Q8WUM0,Q96EE3,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 1.15e-07 231 27 9 0.333 0.039 REAC:195258 rea 1 RHO GTPase Effectors 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 1.73e-07 3499 27 22 0.815 0.006 GO:0044249 BP 1 cellular biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 1.82e-07 964 27 13 0.481 0.013 GO:0015031 BP 1 protein transport 1 Q9BTX1,Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 2.04e-07 1393 27 15 0.556 0.011 GO:0008104 BP 1 protein localization 1 Q9BTX1,Q8WUM0,Q96EE3,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 2.32e-07 4430 27 24 0.889 0.005 GO:0005634 CC 1 nucleus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 2.57e-07 3569 27 22 0.815 0.006 GO:1901576 BP 1 organic substance biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 3.26e-07 657 27 11 0.407 0.017 GO:0033365 BP 1 protein localization to organelle 1 Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,P49792,Q92621,Q8NFH5 95 3.41e-07 3620 27 22 0.815 0.006 GO:0009058 BP 1 biosynthetic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 6.80e-07 5787 27 26 0.963 0.004 GO:0044446 CC 1 intracellular organelle part 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 7.81e-07 3013 27 20 0.741 0.007 GO:0090304 BP 1 nucleic acid metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 8.67e-07 1100 27 13 0.481 0.012 GO:0045184 BP 1 establishment of protein localization 1 Q9BTX1,Q8WUM0,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P49790,Q9BW27,O15504,P49792,Q92621,Q8NFH5 95 1.00e-06 5877 27 26 0.963 0.004 GO:0044422 CC 1 organelle part 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 1.10e-06 65 27 5 0.185 0.077 GO:0034399 CC 1 nuclear periphery 1 Q8N1F7,P52948,P57740,P49790,Q92621 95 1.90e-06 3948 27 22 0.815 0.006 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 2.91e-06 338 27 9 0.333 0.027 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 3.09e-06 3 27 3 0.111 1.000 CORUM:1348 cor 1 GLE1-NUPL2-NUP155 complex 1 O75694,Q53GS7,O15504 95 5.55e-06 3755 27 21 0.778 0.006 GO:0051716 BP 1 cellular response to stimulus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 5.73e-06 11 27 3 0.111 0.273 GO:0042405 CC 1 nuclear inclusion body 1 P52948,P49790,P49792 95 8.10e-06 3443 27 20 0.741 0.006 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 8.51e-06 4264 27 22 0.815 0.005 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 1.02e-05 3882 27 21 0.778 0.005 GO:0016043 BP 1 cellular component organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.40e-05 3554 27 20 0.741 0.006 GO:0046483 BP 1 heterocycle metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.45e-05 3561 27 20 0.741 0.006 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 1.62e-05 2 27 2 0.074 1.000 GO:0031081 BP 1 nuclear pore distribution 1 Q9BTX1,Q8WUM0 95 1.62e-05 2 27 2 0.074 1.000 GO:0000973 BP 1 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery 1 P52948,P57740 95 1.62e-05 2 27 2 0.074 1.000 GO:0051664 BP 1 nuclear pore localization 1 Q9BTX1,Q8WUM0 95 1.83e-05 609 27 9 0.333 0.015 GO:0005694 CC 1 chromosome 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,Q69YH5 95 1.86e-05 4013 27 21 0.778 0.005 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 2.34e-05 17 27 3 0.111 0.176 GO:0034629 BP 1 cellular protein complex localization 1 Q9BTX1,Q8WUM0,Q96EE3 95 2.36e-05 6671 27 26 0.963 0.004 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 2.48e-05 1015 27 11 0.407 0.011 GO:0071822 BP 1 protein complex subunit organization 1 Q9BTX1,Q8WUM0,Q96EE3,Q8N1F7,P52948,P57740,P63165,Q53GS7,P49790,Q92621,Q8NFH5 95 2.55e-05 3681 27 20 0.741 0.005 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5 95 4.86e-05 3 27 2 0.074 0.667 GO:0090521 BP 1 glomerular visceral epithelial cell migration 1 Q5SRE5,Q8N1F7 95 8.09e-05 4356 27 21 0.778 0.005 GO:0050896 BP 1 response to stimulus 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 9.40e-05 565 27 8 0.296 0.014 GO:0044427 CC 1 chromosomal part 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27 95 9.57e-05 5319 27 23 0.852 0.004 GO:0043170 BP 1 macromolecule metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5,Q69YH5 95 1.68e-04 4990 27 22 0.815 0.004 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 2.42e-04 6 27 2 0.074 0.333 GO:0044613 CC 1 nuclear pore central transport channel 1 P49790,Q8NFH5 95 4.46e-04 7517 27 26 0.963 0.003 GO:0043229 CC 1 intracellular organelle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 4.50e-04 8 27 2 0.074 0.250 GO:0000059 BP 1 protein import into nucleus, docking 1 P52948,Q92621 95 5.55e-04 1414 27 11 0.407 0.008 GO:0031090 CC 1 organelle membrane 1 Q9BTX1,Q8WUM0,Q9NRG9,Q8N1F7,P52948,P57740,P63165,P49790,P49792,Q92621,Q8NFH5 95 5.63e-04 1168 27 10 0.370 0.009 GO:1902589 BP 1 single-organism organelle organization 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,P52948,P57740,Q8NFH3,Q9BW27,P49792 95 6.92e-04 750 27 8 0.296 0.011 GO:0005215 MF 1 transporter activity 1 Q12769,Q8WUM0,P52948,P57740,O75694,P49790,O15504,Q8NFH5 95 7.21e-04 10 27 2 0.074 0.200 GO:0016973 BP 1 poly(A)+ mRNA export from nucleus 1 Q8N1F7,Q9UBU9 95 7.25e-04 391 27 6 0.222 0.015 GO:0043623 BP 1 cellular protein complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P49790,Q92621 95 8.05e-04 54 27 3 0.111 0.056 GO:0016234 CC 1 inclusion body 1 P52948,P49790,P49792 95 8.63e-04 6484 27 24 0.889 0.004 GO:0071704 BP 1 organic substance metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,Q69YH5 95 1.10e-03 5533 27 22 0.815 0.004 GO:0050794 BP 1 regulation of cellular process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 1.27e-03 63 27 3 0.111 0.048 GO:0031503 BP 1 protein complex localization 1 Q9BTX1,Q8WUM0,Q96EE3 95 1.41e-03 6642 27 24 0.889 0.004 GO:0008152 BP 1 metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,Q69YH5 95 1.50e-03 6128 27 23 0.852 0.004 GO:0044238 BP 1 primary metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5,Q69YH5 95 1.51e-03 7906 27 26 0.963 0.003 GO:0043227 CC 1 membrane-bounded organelle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 1.80e-03 1614 27 11 0.407 0.007 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q9BTX1,Q8WUM0,Q96EE3,Q8N1F7,P52948,P57740,P63165,Q53GS7,P49790,Q92621,Q8NFH5 95 2.16e-03 17 27 2 0.074 0.118 GO:0008536 MF 1 Ran GTPase binding 1 P49792,O14715 95 2.41e-03 1960 27 12 0.444 0.006 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,P52948,P57740,P63165,Q8NFH3,P49790,Q9BW27,Q69YH5 95 2.41e-03 1960 27 12 0.444 0.006 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q12769,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,P52948,P57740,P63165,Q8NFH3,P49790,Q9BW27,Q69YH5 95 2.52e-03 6299 27 23 0.852 0.004 GO:0044237 BP 1 cellular metabolic process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5,Q69YH5 95 2.85e-03 5839 27 22 0.815 0.004 GO:0050789 BP 1 regulation of biological process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 3.31e-03 21 27 2 0.074 0.095 GO:0006607 BP 1 NLS-bearing protein import into nucleus 1 P49792,Q8NFH5 95 3.64e-03 22 27 2 0.074 0.091 GO:0008139 MF 1 nuclear localization sequence binding 1 P52948,P49790 95 6.18e-03 8385 27 26 0.963 0.003 GO:0043226 CC 1 organelle 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 7.19e-03 1 27 1 0.037 1.000 GO:0070762 CC 1 nuclear pore transmembrane ring 1 Q9BTX1 95 7.19e-03 1 27 1 0.037 1.000 GO:0045759 BP 1 negative regulation of action potential 1 P63165 95 7.19e-03 1 27 1 0.037 1.000 GO:0050290 MF 1 sphingomyelin phosphodiesterase D activity 1 Q9NXE4 95 8.06e-03 842 27 7 0.259 0.008 GO:0006461 BP 1 protein complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P63165,P49790,Q92621 95 8.06e-03 842 27 7 0.259 0.008 GO:0070271 BP 1 protein complex biogenesis 1 Q9BTX1,Q8N1F7,P52948,P57740,P63165,P49790,Q92621 95 8.62e-03 122 27 3 0.111 0.025 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 Q9NRG9,Q8N1F7,P49790 95 8.68e-03 34 27 2 0.074 0.059 GO:0005048 MF 1 signal sequence binding 1 P52948,P49790 95 8.68e-03 34 27 2 0.074 0.059 GO:0051668 BP 1 localization within membrane 1 Q9BTX1,Q8WUM0 95 8.92e-03 6242 27 22 0.815 0.004 GO:0065007 BP 1 biological regulation 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q8NFH5,Q69YH5 95 9.51e-03 6266 27 22 0.815 0.004 GO:0044763 BP 1 single-organism cellular process 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q8NFH5 95 1.27e-02 1 27 1 0.037 1.000 OMIM:613705 omi 1 OROFACIAL CLEFT 10; OFC10;;CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 10 1 P63165 95 1.27e-02 1 27 1 0.037 1.000 OMIM:231550 omi 1 ACHALASIA-ADDISONIANISM-ALACRIMA SYNDROME; AAAS;;TRIPLE-A SYNDROME;;ALACRIMA-ACHALASIA-ADRENAL INSUFFICIENCY NEUROLOGIC DISORDER;;GLUCOCORTICOID DEFICIENCY AND ACHALASIA;;ALLGROVE SYNDROME;;ADDISONIAN-ACHALASIA SYNDROME;;HYPOADRENALISM WITH ACHALASIA;;ALACRIMA-ACHALASIA-ADDISONIANISM;;ACTH-RESISTANT ADRENAL INSUFFICIENCY, ACHALASIA AND ALACRIMAACHALASIA-ALACRIMA SYNDROME, INCLUDED 1 Q9NRG9 95 1.27e-02 1 27 1 0.037 1.000 OMIM:608033 omi 1 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3; IIAE3;;ENCEPHALOPATHY, ACUTE NECROTIZING, SUSCEPTIBILITY TO; ANE 1 P49792 95 1.27e-02 1 27 1 0.037 1.000 OMIM:615770 omi 1 ATRIAL FIBRILLATION, FAMILIAL, 15; ATFB15 1 O75694 95 1.27e-02 1 27 1 0.037 1.000 OMIM:611890 omi 1 LETHAL ARTHROGRYPOSIS WITH ANTERIOR HORN CELL DISEASE; LAAHD 1 Q53GS7 95 1.37e-02 689 27 6 0.222 0.009 GO:0034622 BP 1 cellular macromolecular complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P49790,Q92621 95 1.44e-02 2 27 1 0.037 0.500 GO:0051300 BP 1 spindle pole body organization 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0071789 BP 1 spindle pole body localization to nuclear envelope 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0046832 BP 1 negative regulation of RNA export from nucleus 1 P49790 95 1.44e-02 2 27 1 0.037 0.500 GO:0030474 BP 1 spindle pole body duplication 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0071790 BP 1 establishment of spindle pole body localization to nuclear envelope 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0070631 BP 1 spindle pole body localization 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0090526 BP 1 regulation of gluconeogenesis involved in cellular glucose homeostasis 1 P49792 95 1.44e-02 2 27 1 0.037 0.500 GO:0070632 BP 1 establishment of spindle pole body localization 1 Q9BTX1 95 1.44e-02 2 27 1 0.037 0.500 GO:0032240 BP 1 negative regulation of nucleobase-containing compound transport 1 P49790 95 1.44e-02 2 27 1 0.037 0.500 GO:0036228 BP 1 protein targeting to nuclear inner membrane 1 O75694 95 1.76e-02 1396 27 8 0.296 0.006 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,P49792,Q9UBU9,Q8NFH5 95 2.15e-02 3 27 1 0.037 0.333 GO:1902260 BP 1 negative regulation of delayed rectifier potassium channel activity 1 P63165 95 2.15e-02 3 27 1 0.037 0.333 GO:0000822 MF 1 inositol hexakisphosphate binding 1 Q53GS7 95 2.15e-02 3 27 1 0.037 0.333 GO:0033132 BP 1 negative regulation of glucokinase activity 1 P49792 95 2.15e-02 3 27 1 0.037 0.333 GO:1903817 BP 1 negative regulation of voltage-gated potassium channel activity 1 P63165 95 2.15e-02 3 27 1 0.037 0.333 GO:1903300 BP 1 negative regulation of hexokinase activity 1 P49792 95 2.31e-02 56 27 2 0.074 0.036 GO:0050000 BP 1 chromosome localization 1 Q96EE3,P52948 95 2.52e-02 5 27 1 0.037 0.200 REAC:3065676 rea 1 SUMO is conjugated to E1 (UBA2:SAE1) 1 P63165 95 2.53e-02 2 27 1 0.037 0.500 OMIM:610551 omi 1 Susceptibility to Acute Infection-Induced Encephalopathy, including Herpes Simplex Encephalitis 1 P49792 95 2.57e-02 8911 27 26 0.963 0.003 GO:0044424 CC 1 intracellular part 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 2.87e-02 4 27 1 0.037 0.250 GO:0034398 BP 1 telomere tethering at nuclear periphery 1 P52948 95 2.87e-02 4 27 1 0.037 0.250 GO:0034397 BP 1 telomere localization 1 P52948 95 2.87e-02 4 27 1 0.037 0.250 GO:1904263 BP 1 positive regulation of TORC1 signaling 1 Q96EE3 95 3.00e-02 1247 27 7 0.259 0.006 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 P63165,Q53GS7,P49790,Q9BW27,P49792,Q9UBU9,Q8NFH5 95 3.02e-02 6 27 1 0.037 0.167 REAC:3065679 rea 1 SUMO is proteolytically processed 1 P63165 95 3.09e-02 8982 27 26 0.963 0.003 GO:0005622 CC 1 intracellular 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 3.18e-02 4682 27 17 0.630 0.004 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 Q8WUM0,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P57740,P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q9UBU9,Q8NFH5,Q69YH5 95 3.33e-02 1274 27 7 0.259 0.005 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P63165,Q53GS7,Q8NFH3,P49790,P49792,Q9UBU9,Q8NFH5 95 3.37e-02 9455 27 27 1.000 0.003 TF:M07056_0 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 0 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,Q96SK2,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 3.37e-02 9455 27 27 1.000 0.003 TF:M02114_0 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 0 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,Q6NUQ4,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,Q9NXE4,Q96SK2,P49792,Q92621,Q9UBU9,Q8NFH5,O14715,Q69YH5 95 3.43e-02 1576 27 8 0.296 0.005 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,P49792,Q9UBU9,Q8NFH5 95 3.52e-02 7 27 1 0.037 0.143 REAC:3065678 rea 1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 P63165 95 3.58e-02 5 27 1 0.037 0.200 GO:0004767 MF 1 sphingomyelin phosphodiesterase activity 1 Q9NXE4 95 3.58e-02 5 27 1 0.037 0.200 GO:0033131 BP 1 regulation of glucokinase activity 1 P49792 95 3.58e-02 5 27 1 0.037 0.200 GO:0043495 MF 1 protein anchor 1 P49790 95 3.58e-02 5 27 1 0.037 0.200 GO:0006685 BP 1 sphingomyelin catabolic process 1 Q9NXE4 95 3.65e-02 753 27 5 0.185 0.007 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P63165,Q8NFH3,P49790,P49792,Q9UBU9 95 3.71e-02 1113 27 7 0.259 0.006 GO:0065003 BP 1 macromolecular complex assembly 1 Q9BTX1,Q8N1F7,P52948,P57740,P63165,P49790,Q92621 95 3.95e-02 4600 27 17 0.630 0.004 GO:0016020 CC 1 membrane 1 Q9BTX1,Q8WUM0,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q53GS7,P49790,Q9BW27,Q8TEM1,Q9NXE4,P49792,Q92621,Q8NFH5 95 4.14e-02 531 27 4 0.148 0.008 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 P63165,P49790,P49792,Q9UBU9 95 4.29e-02 6 27 1 0.037 0.167 GO:0090435 BP 1 protein localization to nuclear envelope 1 O75694 95 4.29e-02 6 27 1 0.037 0.167 GO:0031386 MF 1 protein tag 1 P63165 95 4.29e-02 6 27 1 0.037 0.167 GO:0006449 BP 1 regulation of translational termination 1 Q53GS7 95 4.29e-02 6 27 1 0.037 0.167 GO:1903299 BP 1 regulation of hexokinase activity 1 P49792 95 4.49e-02 1659 27 8 0.296 0.005 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P63165,Q53GS7,Q8NFH3,P49790,Q9BW27,P49792,Q9UBU9,Q8NFH5 95 4.66e-02 1078 27 6 0.222 0.006 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P63165,Q53GS7,Q8NFH3,P49790,P49792,Q9UBU9 95 4.89e-02 1091 27 6 0.222 0.005 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 P63165,Q53GS7,P49790,Q9BW27,P49792,Q9UBU9 95 5.00e-02 1 27 1 0.037 1.000 HP:0100333 hp 1 Unilateral cleft lip 1 P63165 95 5.00e-02 1 27 1 0.037 1.000 HP:0004571 hp 1 Widening of cervical spinal canal 1 Q53GS7 95 5.00e-02 7 27 1 0.037 0.143 GO:0060391 BP 1 positive regulation of SMAD protein import into nucleus 1 Q8N1F7 95 5.00e-02 4 27 1 0.037 0.250 OMIM:608583 omi 1 Familial Atrial Fibrillation 1 O75694 95 5.00e-02 152 27 22 0.815 0.145 KEGG:03013 keg 1 RNA transport 1 Q12769,Q9BTX1,Q8WUM0,Q8NFH4,Q96EE3,Q9NRG9,Q5SRE5,Q8N1F7,P52948,P57740,O75694,P63165,Q8NFH3,P49790,Q9BW27,Q8TEM1,O15504,P49792,Q92621,Q9UBU9,Q8NFH5,O14715 95 5.00e-02 1 27 1 0.037 1.000 HP:0007277 hp 1 Paucity of anterior horn motor neurons 1 Q53GS7 95 5.00e-02 2 27 1 0.037 0.500 CORUM:1056 cor 1 ZNF198-SUMO1 complex 1 P63165 95 5.00e-02 500 27 7 0.259 0.014 MI:hsa-miR-524-5p mi 1 MI:hsa-miR-524-5p 1 Q8NFH4,Q8N1F7,P57740,Q9BW27,O15504,Q92621,Q9UBU9 95 5.00e-02 10 27 1 0.037 0.100 REAC:3215018 rea 1 Processing and activation of SUMO 1 P63165 95 5.00e-02 1 27 1 0.037 1.000 HP:0100334 hp 1 Unilateral cleft palate 1 P63165 95 5.00e-02 1176 27 9 0.333 0.008 TF:M01261_0 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 0 1 Q9BTX1,Q8WUM0,Q8NFH4,Q5SRE5,P52948,P63165,Q53GS7,Q8TEM1,O14715 96 9.66e-06 19 2 2 1.000 0.105 GO:0003887 MF 1 DNA-directed DNA polymerase activity 1 P54098,Q9UHN1 96 1.00e-05 6 2 2 1.000 0.333 HP:0006858 hp 1 Impaired distal proprioception 1 P54098,Q9UHN1 96 1.00e-05 6 2 2 1.000 0.333 HP:0002578 hp 1 Gastroparesis 1 P54098,Q9UHN1 96 1.40e-05 7 2 2 1.000 0.286 HP:0009141 hp 1 Depletion of mitochondrial DNA in muscle tissue 1 P54098,Q9UHN1 96 1.40e-05 7 2 2 1.000 0.286 HP:0003689 hp 1 Multiple mitochondrial DNA deletions 1 P54098,Q9UHN1 96 1.84e-05 26 2 2 1.000 0.077 GO:0034061 MF 1 DNA polymerase activity 1 P54098,Q9UHN1 96 1.87e-05 8 2 2 1.000 0.250 HP:0003548 hp 1 Subsarcolemmal accumulations of abnormally shaped mitochondria 1 P54098,Q9UHN1 96 2.67e-05 6 2 2 1.000 0.333 OMIM:157640 omi 1 Autosomal Dominant Progressive External Ophthalmoplegia with DNA Deletions 1 P54098,Q9UHN1 96 3.01e-05 10 2 2 1.000 0.200 HP:0003750 hp 1 Increased muscle fatiguability 1 P54098,Q9UHN1 96 3.01e-05 10 2 2 1.000 0.200 HP:0003713 hp 1 Muscle fiber necrosis 1 P54098,Q9UHN1 96 3.67e-05 11 2 2 1.000 0.182 HP:0006886 hp 1 Impaired distal vibration sensation 1 P54098,Q9UHN1 96 3.67e-05 11 2 2 1.000 0.182 HP:0010871 hp 1 Sensory ataxia 1 P54098,Q9UHN1 96 4.19e-05 39 2 2 1.000 0.051 GO:0042645 CC 1 mitochondrial nucleoid 1 P54098,Q9UHN1 96 4.63e-05 41 2 2 1.000 0.049 GO:0009295 CC 1 nucleoid 1 P54098,Q9UHN1 96 6.08e-05 14 2 2 1.000 0.143 HP:0000590 hp 1 Progressive external ophthalmoplegia 1 P54098,Q9UHN1 96 7.02e-05 15 2 2 1.000 0.133 HP:0012378 hp 1 Fatigue 1 P54098,Q9UHN1 96 1.40e-04 21 2 2 1.000 0.095 HP:0003390 hp 1 Sensory axonal neuropathy 1 P54098,Q9UHN1 96 1.40e-04 21 2 2 1.000 0.095 HP:0010831 hp 1 Impaired proprioception 1 P54098,Q9UHN1 96 1.54e-04 22 2 2 1.000 0.091 HP:0003557 hp 1 Increased variability in muscle fiber diameter 1 P54098,Q9UHN1 96 1.54e-04 22 2 2 1.000 0.091 HP:0002548 hp 1 Parkinsonism with favorable response to dopaminergic medication 1 P54098,Q9UHN1 96 1.54e-04 22 2 2 1.000 0.091 HP:0002322 hp 1 Resting tremor 1 P54098,Q9UHN1 96 1.54e-04 22 2 2 1.000 0.091 HP:0003688 hp 1 Decreased activity of cytochrome C oxidase in muscle tissue 1 P54098,Q9UHN1 96 1.84e-04 24 2 2 1.000 0.083 HP:0008209 hp 1 Premature ovarian failure 1 P54098,Q9UHN1 96 1.84e-04 24 2 2 1.000 0.083 HP:0000869 hp 1 Secondary amenorrhea 1 P54098,Q9UHN1 96 2.00e-04 25 2 2 1.000 0.080 HP:0012084 hp 1 Abnormality of skeletal muscle fiber size 1 P54098,Q9UHN1 96 2.53e-04 28 2 2 1.000 0.071 HP:0000029 hp 1 Testicular atrophy 1 P54098,Q9UHN1 96 2.71e-04 29 2 2 1.000 0.069 HP:0000833 hp 1 Glucose intolerance 1 P54098,Q9UHN1 96 2.71e-04 29 2 2 1.000 0.069 HP:0003800 hp 1 Muscle abnormality related to mitochondrial dysfunction 1 P54098,Q9UHN1 96 3.08e-04 105 2 2 1.000 0.019 GO:0016779 MF 1 nucleotidyltransferase activity 1 P54098,Q9UHN1 96 3.11e-04 31 2 2 1.000 0.065 HP:0003458 hp 1 EMG: myopathic abnormalities 1 P54098,Q9UHN1 96 3.53e-04 33 2 2 1.000 0.061 HP:0001662 hp 1 Bradycardia 1 P54098,Q9UHN1 96 3.75e-04 34 2 2 1.000 0.059 HP:0001952 hp 1 Abnormal glucose tolerance 1 P54098,Q9UHN1 96 3.97e-04 119 2 2 1.000 0.017 GO:0006261 BP 1 DNA-dependent DNA replication 1 P54098,Q9UHN1 96 3.98e-04 35 2 2 1.000 0.057 HP:0002495 hp 1 Impaired vibratory sensation 1 P54098,Q9UHN1 96 4.21e-04 36 2 2 1.000 0.056 HP:0003323 hp 1 Progressive muscle weakness 1 P54098,Q9UHN1 96 4.70e-04 38 2 2 1.000 0.053 HP:0000544 hp 1 External ophthalmoplegia 1 P54098,Q9UHN1 96 4.70e-04 38 2 2 1.000 0.053 HP:0003200 hp 1 Ragged-red muscle fibers 1 P54098,Q9UHN1 96 6.32e-04 44 2 2 1.000 0.045 HP:0100704 hp 1 Cortical visual impairment 1 P54098,Q9UHN1 96 6.32e-04 44 2 2 1.000 0.045 HP:0000815 hp 1 Hypergonadotropic hypogonadism 1 P54098,Q9UHN1 96 6.51e-04 1 2 1 0.500 1.000 GO:0000262 CC 1 mitochondrial chromosome 1 Q9UHN1 96 6.92e-04 46 2 2 1.000 0.043 HP:0000786 hp 1 Primary amenorrhea 1 P54098,Q9UHN1 96 7.86e-04 49 2 2 1.000 0.041 HP:0003324 hp 1 Generalized muscle weakness 1 P54098,Q9UHN1 96 1.10e-03 58 2 2 1.000 0.034 HP:0002067 hp 1 Bradykinesia 1 P54098,Q9UHN1 96 1.14e-03 59 2 2 1.000 0.034 HP:0001618 hp 1 Dysphonia 1 P54098,Q9UHN1 96 1.18e-03 60 2 2 1.000 0.033 HP:0000141 hp 1 Amenorrhea 1 P54098,Q9UHN1 96 1.30e-03 2 2 1 0.500 0.500 GO:0006426 BP 1 glycyl-tRNA aminoacylation 1 Q9UHN1 96 1.30e-03 2 2 1 0.500 0.500 GO:0000229 CC 1 cytoplasmic chromosome 1 Q9UHN1 96 1.30e-03 2 2 1 0.500 0.500 GO:0004820 MF 1 glycine-tRNA ligase activity 1 Q9UHN1 96 1.32e-03 217 2 2 1.000 0.009 GO:0006260 BP 1 DNA replication 1 P54098,Q9UHN1 96 1.52e-03 68 2 2 1.000 0.029 HP:0002066 hp 1 Gait ataxia 1 P54098,Q9UHN1 96 1.52e-03 68 2 2 1.000 0.029 HP:0001300 hp 1 Parkinsonism 1 P54098,Q9UHN1 96 1.57e-03 69 2 2 1.000 0.029 HP:0003477 hp 1 Peripheral axonal neuropathy 1 P54098,Q9UHN1 96 1.61e-03 70 2 2 1.000 0.029 HP:0000716 hp 1 Depression 1 P54098,Q9UHN1 96 1.79e-03 1 2 1 0.500 1.000 HP:0006964 hp 1 Cerebral cortical neurodegeneration 1 P54098 96 1.95e-03 3 2 1 0.500 0.333 GO:0006287 BP 1 base-excision repair, gap-filling 1 P54098 96 2.06e-03 79 2 2 1.000 0.025 HP:0003326 hp 1 Myalgia 1 P54098,Q9UHN1 96 2.56e-03 88 2 2 1.000 0.023 HP:0000763 hp 1 Sensory neuropathy 1 P54098,Q9UHN1 96 2.80e-03 92 2 2 1.000 0.022 HP:0002063 hp 1 Rigidity 1 P54098,Q9UHN1 96 2.86e-03 93 2 2 1.000 0.022 HP:0000140 hp 1 Abnormality of the menstrual cycle 1 P54098,Q9UHN1 96 2.98e-03 95 2 2 1.000 0.021 HP:0002020 hp 1 Gastroesophageal reflux 1 P54098,Q9UHN1 96 3.11e-03 97 2 2 1.000 0.021 HP:0003690 hp 1 Limb muscle weakness 1 P54098,Q9UHN1 96 3.18e-03 98 2 2 1.000 0.020 HP:0000739 hp 1 Anxiety 1 P54098,Q9UHN1 96 3.18e-03 98 2 2 1.000 0.020 HP:0001730 hp 1 Progressive hearing impairment 1 P54098,Q9UHN1 96 3.24e-03 99 2 2 1.000 0.020 HP:0002936 hp 1 Distal sensory impairment 1 P54098,Q9UHN1 96 3.33e-03 344 2 2 1.000 0.006 GO:0005759 CC 1 mitochondrial matrix 1 P54098,Q9UHN1 96 3.37e-03 101 2 2 1.000 0.020 HP:0000858 hp 1 Menstrual irregularities 1 P54098,Q9UHN1 96 3.37e-03 101 2 2 1.000 0.020 HP:0000764 hp 1 Peripheral axonal degeneration 1 P54098,Q9UHN1 96 3.37e-03 101 2 2 1.000 0.020 HP:0100852 hp 1 Abnormal fear/anxiety-related behavior 1 P54098,Q9UHN1 96 3.44e-03 102 2 2 1.000 0.020 HP:0003546 hp 1 Exercise intolerance 1 P54098,Q9UHN1 96 3.51e-03 103 2 2 1.000 0.019 HP:0000602 hp 1 Ophthalmoplegia 1 P54098,Q9UHN1 96 3.59e-03 2 2 1 0.500 0.500 HP:0012847 hp 1 Epilepsia partialis continua 1 P54098 96 3.86e-03 108 2 2 1.000 0.019 HP:0002151 hp 1 Increased serum lactate 1 P54098,Q9UHN1 96 4.15e-03 384 2 2 1.000 0.005 GO:0006281 BP 1 DNA repair 1 P54098,Q9UHN1 96 4.38e-03 115 2 2 1.000 0.017 HP:0010827 hp 1 Abnormality of the seventh cranial nerve 1 P54098,Q9UHN1 96 4.38e-03 115 2 2 1.000 0.017 HP:0000137 hp 1 Abnormality of the ovary 1 P54098,Q9UHN1 96 4.38e-03 115 2 2 1.000 0.017 HP:0010628 hp 1 Facial palsy 1 P54098,Q9UHN1 96 4.46e-03 116 2 2 1.000 0.017 HP:0000726 hp 1 Dementia 1 P54098,Q9UHN1 96 4.46e-03 116 2 2 1.000 0.017 HP:0030319 hp 1 Weakness of facial musculature 1 P54098,Q9UHN1 96 4.55e-03 1 2 1 0.500 1.000 OMIM:607459 omi 1 SENSORY ATAXIC NEUROPATHY, DYSARTHRIA, AND OPHTHALMOPARESIS; SANDO;;SENSORY ATAXIC NEUROPATHY WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMALRECESSIVESPINOCEREBELLAR ATAXIA WITH EPILEPSY, INCLUDED; SCAE, INCLUDED 1 P54098 96 4.55e-03 1 2 1 0.500 1.000 OMIM:613662 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 4B (MNGIE TYPE); MTDPS4B;;MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME, POLG-RELATED;;MNGIE, POLG-RELATED 1 P54098 96 4.55e-03 1 2 1 0.500 1.000 OMIM:610131 omi 1 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT 4; PEOA4;;PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, AUTOSOMAL DOMINANT 4 1 Q9UHN1 96 4.55e-03 1 2 1 0.500 1.000 OMIM:203700 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 4A (ALPERS TYPE); MTDPS4A;;ALPERS DIFFUSE DEGENERATION OF CEREBRAL GRAY MATTER WITH HEPATIC CIRRHOSIS;;ALPERS PROGRESSIVE INFANTILE POLIODYSTROPHY;;ALPERS SYNDROME;;ALPERS-HUTTENLOCHER SYNDROME;;NEURONAL DEGENERATION OF CHILDHOOD WITH LIVER DISEASE, PROGRESSIVE;PNDC 1 P54098 96 5.38e-03 3 2 1 0.500 0.333 HP:0100613 hp 1 Death in early adulthood 1 P54098 96 5.38e-03 3 2 1 0.500 0.333 HP:0002254 hp 1 Intermittent diarrhea 1 P54098 96 5.60e-03 130 2 2 1.000 0.015 HP:0002910 hp 1 Elevated hepatic transaminases 1 P54098,Q9UHN1 96 6.04e-03 135 2 2 1.000 0.015 HP:0004303 hp 1 Abnormality of muscle fibers 1 P54098,Q9UHN1 96 6.04e-03 135 2 2 1.000 0.015 HP:0003457 hp 1 EMG abnormality 1 P54098,Q9UHN1 96 6.51e-03 10 2 1 0.500 0.100 GO:0006264 BP 1 mitochondrial DNA replication 1 P54098 96 7.17e-03 4 2 1 0.500 0.250 HP:0007344 hp 1 Atrophy/Degeneration involving the spinal cord 1 P54098 96 7.17e-03 4 2 1 0.500 0.250 HP:0004389 hp 1 Intestinal pseudo-obstruction 1 P54098 96 7.33e-03 510 2 2 1.000 0.004 GO:0007005 BP 1 mitochondrion organization 1 P54098,Q9UHN1 96 7.47e-03 150 2 2 1.000 0.013 HP:0000135 hp 1 Hypogonadism 1 P54098,Q9UHN1 96 7.57e-03 151 2 2 1.000 0.013 HP:0003474 hp 1 Sensory impairment 1 P54098,Q9UHN1 96 7.81e-03 12 2 1 0.500 0.083 GO:0032042 BP 1 mitochondrial DNA metabolic process 1 P54098 96 7.87e-03 154 2 2 1.000 0.013 HP:0003198 hp 1 Myopathy 1 P54098,Q9UHN1 96 7.87e-03 154 2 2 1.000 0.013 HP:0000301 hp 1 Abnormality of facial musculature 1 P54098,Q9UHN1 96 8.39e-03 159 2 2 1.000 0.013 HP:0006824 hp 1 Cranial nerve paralysis 1 P54098,Q9UHN1 96 8.82e-03 163 2 2 1.000 0.012 HP:0002071 hp 1 Abnormality of extrapyramidal motor function 1 P54098,Q9UHN1 96 8.97e-03 5 2 1 0.500 0.200 HP:0003434 hp 1 Sensory ataxic neuropathy 1 P54098 96 9.11e-03 2 2 1 0.500 0.500 OMIM:258450 omi 1 Autosomal Recessive External Ophthalmoplegia with Mitochondrial DNA Deletions 1 P54098 96 9.26e-03 167 2 2 1.000 0.012 HP:0001761 hp 1 Pes cavus 1 P54098,Q9UHN1 96 9.88e-03 592 2 2 1.000 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P54098,Q9UHN1 96 1.01e-02 174 2 2 1.000 0.011 HP:0003236 hp 1 Elevated serum creatine phosphokinase 1 P54098,Q9UHN1 96 1.01e-02 174 2 2 1.000 0.011 HP:0011021 hp 1 Abnormality of circulating enzyme level 1 P54098,Q9UHN1 96 1.01e-02 174 2 2 1.000 0.011 HP:0040081 hp 1 Abnormal levels of creatine kinase in blood 1 P54098,Q9UHN1 96 1.04e-02 177 2 2 1.000 0.011 HP:0001284 hp 1 Areflexia 1 P54098,Q9UHN1 96 1.05e-02 178 2 2 1.000 0.011 HP:0002019 hp 1 Constipation 1 P54098,Q9UHN1 96 1.05e-02 178 2 2 1.000 0.011 HP:0000597 hp 1 Ophthalmoparesis 1 P54098,Q9UHN1 96 1.06e-02 179 2 2 1.000 0.011 HP:0001268 hp 1 Mental deterioration 1 P54098,Q9UHN1 96 1.08e-02 6 2 1 0.500 0.167 HP:0007240 hp 1 Progressive gait ataxia 1 P54098 96 1.08e-02 6 2 1 0.500 0.167 HP:0003219 hp 1 Ethylmalonic aciduria 1 P54098 96 1.08e-02 180 2 2 1.000 0.011 HP:0003701 hp 1 Proximal muscle weakness 1 P54098,Q9UHN1 96 1.15e-02 186 2 2 1.000 0.011 HP:0002015 hp 1 Dysphagia 1 P54098,Q9UHN1 96 1.17e-02 188 2 2 1.000 0.011 HP:0000820 hp 1 Abnormality of the thyroid gland 1 P54098,Q9UHN1 96 1.25e-02 7 2 1 0.500 0.143 HP:0004326 hp 1 Cachexia 1 P54098 96 1.27e-02 670 2 2 1.000 0.003 GO:0006259 BP 1 DNA metabolic process 1 P54098,Q9UHN1 96 1.28e-02 674 2 2 1.000 0.003 GO:0044429 CC 1 mitochondrial part 1 P54098,Q9UHN1 96 1.30e-02 20 2 1 0.500 0.050 GO:0000002 BP 1 mitochondrial genome maintenance 1 P54098 96 1.33e-02 200 2 2 1.000 0.010 HP:0000819 hp 1 Diabetes mellitus 1 P54098,Q9UHN1 96 1.36e-02 202 2 2 1.000 0.010 HP:0001291 hp 1 Abnormality of the cranial nerves 1 P54098,Q9UHN1 96 1.47e-02 210 2 2 1.000 0.010 HP:0003676 hp 1 Progressive 1 P54098,Q9UHN1 96 1.49e-02 212 2 2 1.000 0.009 HP:0000501 hp 1 Glaucoma 1 P54098,Q9UHN1 96 1.51e-02 213 2 2 1.000 0.009 HP:0003581 hp 1 Adult onset 1 P54098,Q9UHN1 96 1.52e-02 214 2 2 1.000 0.009 HP:0011799 hp 1 Abnormality of facial soft tissue 1 P54098,Q9UHN1 96 1.58e-02 218 2 2 1.000 0.009 HP:0004302 hp 1 Functional motor problems 1 P54098,Q9UHN1 96 1.61e-02 755 2 2 1.000 0.003 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P54098,Q9UHN1 96 1.64e-02 222 2 2 1.000 0.009 HP:0009127 hp 1 Abnormality of the musculature of the limbs 1 P54098,Q9UHN1 96 1.73e-02 228 2 2 1.000 0.009 HP:0010876 hp 1 Abnormality of circulating protein level 1 P54098,Q9UHN1 96 1.74e-02 229 2 2 1.000 0.009 HP:0001272 hp 1 Cerebellar atrophy 1 P54098,Q9UHN1 96 1.76e-02 230 2 2 1.000 0.009 HP:0000080 hp 1 Abnormality of reproductive system physiology 1 P54098,Q9UHN1 96 1.79e-02 10 2 1 0.500 0.100 HP:0002446 hp 1 Astrocytosis 1 P54098 96 1.79e-02 10 2 1 0.500 0.100 HP:0004395 hp 1 Malnutrition 1 P54098 96 1.87e-02 237 2 2 1.000 0.008 HP:0001265 hp 1 Hyporeflexia 1 P54098,Q9UHN1 96 1.88e-02 238 2 2 1.000 0.008 HP:0001941 hp 1 Acidosis 1 P54098,Q9UHN1 96 2.00e-02 245 2 2 1.000 0.008 HP:0002577 hp 1 Abnormality of the stomach 1 P54098,Q9UHN1 96 2.03e-02 247 2 2 1.000 0.008 HP:0001608 hp 1 Abnormality of the voice 1 P54098,Q9UHN1 96 2.06e-02 249 2 2 1.000 0.008 HP:0004360 hp 1 Abnormality of acid-base homeostasis 1 P54098,Q9UHN1 96 2.08e-02 32 2 1 0.500 0.031 GO:0006284 BP 1 base-excision repair 1 P54098 96 2.15e-02 12 2 1 0.500 0.083 HP:0007103 hp 1 Hypointensity of cerebral white matter on MRI 1 P54098 96 2.15e-02 12 2 1 0.500 0.083 HP:0002403 hp 1 Positive Romberg sign 1 P54098 96 2.15e-02 12 2 1 0.500 0.083 HP:0000114 hp 1 Proximal tubulopathy 1 P54098 96 2.18e-02 256 2 2 1.000 0.008 HP:0003828 hp 1 Variable expressivity 1 P54098,Q9UHN1 96 2.23e-02 259 2 2 1.000 0.008 HP:0011675 hp 1 Arrhythmia 1 P54098,Q9UHN1 96 2.34e-02 265 2 2 1.000 0.008 HP:0008373 hp 1 Puberty and gonadal disorders 1 P54098,Q9UHN1 96 2.51e-02 14 2 1 0.500 0.071 HP:0003535 hp 1 3-Methylglutaconic aciduria 1 P54098 96 2.69e-02 15 2 1 0.500 0.067 HP:0001413 hp 1 Micronodular cirrhosis 1 P54098 96 2.73e-02 42 2 1 0.500 0.024 GO:0016875 MF 1 ligase activity, forming carbon-oxygen bonds 1 Q9UHN1 96 2.73e-02 42 2 1 0.500 0.024 GO:0016876 MF 1 ligase activity, forming aminoacyl-tRNA and related compounds 1 Q9UHN1 96 2.73e-02 42 2 1 0.500 0.024 GO:0004812 MF 1 aminoacyl-tRNA ligase activity 1 Q9UHN1 96 2.86e-02 44 2 1 0.500 0.023 GO:0008408 MF 1 3'-5' exonuclease activity 1 P54098 96 2.86e-02 16 2 1 0.500 0.062 HP:0003737 hp 1 Mitochondrial myopathy 1 P54098 96 2.86e-02 16 2 1 0.500 0.062 HP:0001414 hp 1 Microvesicular hepatic steatosis 1 P54098 96 2.99e-02 1029 2 2 1.000 0.002 GO:0005739 CC 1 mitochondrion 1 P54098,Q9UHN1 96 3.06e-02 47 2 1 0.500 0.021 GO:0006418 BP 1 tRNA aminoacylation for protein translation 1 Q9UHN1 96 3.08e-02 304 2 2 1.000 0.007 HP:0000008 hp 1 Abnormality of female internal genitalia 1 P54098,Q9UHN1 96 3.12e-02 306 2 2 1.000 0.007 HP:0001337 hp 1 Tremor 1 P54098,Q9UHN1 96 3.25e-02 50 2 1 0.500 0.020 GO:0043039 BP 1 tRNA aminoacylation 1 Q9UHN1 96 3.25e-02 50 2 1 0.500 0.020 GO:0043038 BP 1 amino acid activation 1 Q9UHN1 96 3.45e-02 322 2 2 1.000 0.006 HP:0001260 hp 1 Dysarthria 1 P54098,Q9UHN1 96 3.54e-02 326 2 2 1.000 0.006 HP:0009830 hp 1 Peripheral neuropathy 1 P54098,Q9UHN1 96 3.58e-02 20 2 1 0.500 0.050 HP:0002922 hp 1 Increased CSF protein 1 P54098 96 3.65e-02 331 2 2 1.000 0.006 HP:0002031 hp 1 Abnormality of the esophagus 1 P54098,Q9UHN1 96 3.67e-02 332 2 2 1.000 0.006 HP:0001315 hp 1 Reduced tendon reflexes 1 P54098,Q9UHN1 96 3.69e-02 333 2 2 1.000 0.006 HP:0001638 hp 1 Cardiomyopathy 1 P54098,Q9UHN1 96 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 P54098,Q9UHN1 96 3.83e-02 339 2 2 1.000 0.006 HP:0000812 hp 1 Abnormal internal genitalia 1 P54098,Q9UHN1 96 3.85e-02 340 2 2 1.000 0.006 HP:0010460 hp 1 Abnormality of the female genitalia 1 P54098,Q9UHN1 96 3.99e-02 346 2 2 1.000 0.006 HP:0011014 hp 1 Abnormal glucose homeostasis 1 P54098,Q9UHN1 96 4.08e-02 350 2 2 1.000 0.006 HP:0001637 hp 1 Abnormality of the myocardium 1 P54098,Q9UHN1 96 4.12e-02 42 2 1 0.500 0.024 REAC:2151201 rea 1 Transcriptional activation of mitochondrial biogenesis 1 Q9UHN1 96 4.15e-02 1212 2 2 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 P54098,Q9UHN1 96 4.22e-02 65 2 1 0.500 0.015 GO:0004527 MF 1 exonuclease activity 1 P54098 96 4.34e-02 361 2 2 1.000 0.006 HP:0000508 hp 1 Ptosis 1 P54098,Q9UHN1 96 4.44e-02 365 2 2 1.000 0.005 HP:0002059 hp 1 Cerebral atrophy 1 P54098,Q9UHN1 96 4.51e-02 368 2 2 1.000 0.005 HP:0007369 hp 1 Atrophy/Degeneration affecting the cerebrum 1 P54098,Q9UHN1 96 4.71e-02 376 2 2 1.000 0.005 HP:0001322 hp 1 Brain very small 1 P54098,Q9UHN1 96 4.71e-02 376 2 2 1.000 0.005 HP:0012444 hp 1 Brain atrophy 1 P54098,Q9UHN1 96 4.82e-02 27 2 1 0.500 0.037 HP:0002344 hp 1 Progressive neurologic deterioration 1 P54098 96 4.86e-02 382 2 2 1.000 0.005 HP:0003202 hp 1 Skeletal muscle atrophy 1 P54098,Q9UHN1 96 5.00e-02 585 2 2 1.000 0.003 TF:M02085_1 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 1 1 P54098,Q9UHN1 96 5.00e-02 51 2 1 0.500 0.020 REAC:1592230 rea 1 Mitochondrial biogenesis 1 Q9UHN1 96 5.00e-02 11 2 1 0.500 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 P54098 96 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 P54098,Q9UHN1 96 5.00e-02 28 2 1 0.500 0.036 HP:0003376 hp 1 Steppage gait 1 P54098 96 5.00e-02 28 2 1 0.500 0.036 HP:0003700 hp 1 Generalized amyotrophy 1 P54098 96 5.00e-02 77 2 1 0.500 0.013 GO:0002020 MF 1 protease binding 1 P54098 97 7.27e-05 8 4 2 0.500 0.250 GO:0099078 CC 1 BORC complex 1 Q96GS4,Q96FH0 97 7.42e-03 404 4 2 0.500 0.005 MI:hsa-miR-611 mi 1 MI:hsa-miR-611 1 Q2TAC2,Q96GS4 97 8.54e-03 434 4 2 0.500 0.005 MI:hsa-miR-139-3p mi 1 MI:hsa-miR-139-3p 1 Q2TAC2,Q96GS4 97 8.91e-03 1462 4 3 0.750 0.002 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 Q2TAC2,Q96GS4,Q96FH0 97 2.20e-02 682 4 2 0.500 0.003 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 Q96GS4,Q96FH0 97 2.99e-02 4491 4 4 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q9ULJ1,Q2TAC2,Q96GS4,Q96FH0 97 4.15e-02 4872 4 4 1.000 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q9ULJ1,Q2TAC2,Q96GS4,Q96FH0 97 4.15e-02 1736 4 4 1.000 0.002 TF:M00187_1 tf 1 Factor: USF; motif: GYCACGTGNC; match class: 1 1 Q9ULJ1,Q2TAC2,Q96GS4,Q96FH0 97 4.43e-02 4954 4 4 1.000 0.001 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 Q9ULJ1,Q2TAC2,Q96GS4,Q96FH0 97 5.00e-02 199 4 2 0.500 0.010 GO:0044445 CC 1 cytosolic part 1 Q96GS4,Q96FH0 97 5.00e-02 107 4 2 0.500 0.019 TF:M04163_0 tf 1 Factor: BHLHE41; motif: NKCACGTGMC; match class: 0 1 Q96GS4,Q96FH0 98 7.12e-08 3 2 2 1.000 0.667 GO:0047023 MF 1 androsterone dehydrogenase activity 1 P42330,P17516 98 1.42e-07 4 2 2 1.000 0.500 GO:0009753 BP 1 response to jasmonic acid 1 P42330,P17516 98 1.42e-07 4 2 2 1.000 0.500 GO:0071395 BP 1 cellular response to jasmonic acid stimulus 1 P42330,P17516 98 2.37e-07 5 2 2 1.000 0.400 GO:0001758 MF 1 retinal dehydrogenase activity 1 P42330,P17516 98 6.65e-07 8 2 2 1.000 0.250 GO:0030638 BP 1 polyketide metabolic process 1 P42330,P17516 98 6.65e-07 8 2 2 1.000 0.250 GO:0044597 BP 1 daunorubicin metabolic process 1 P42330,P17516 98 6.65e-07 8 2 2 1.000 0.250 GO:0030647 BP 1 aminoglycoside antibiotic metabolic process 1 P42330,P17516 98 6.65e-07 8 2 2 1.000 0.250 GO:0044598 BP 1 doxorubicin metabolic process 1 P42330,P17516 98 1.82e-06 10 2 2 1.000 0.200 REAC:193807 rea 1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1 P42330,P17516 98 1.82e-06 10 2 2 1.000 0.200 REAC:193775 rea 1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 1 P42330,P17516 98 1.85e-06 13 2 2 1.000 0.154 GO:0016137 BP 1 glycoside metabolic process 1 P42330,P17516 98 3.23e-06 17 2 2 1.000 0.118 GO:0033764 MF 1 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P42330,P17516 98 3.63e-06 18 2 2 1.000 0.111 GO:0016229 MF 1 steroid dehydrogenase activity 1 P42330,P17516 98 4.51e-06 20 2 2 1.000 0.100 GO:1901661 BP 1 quinone metabolic process 1 P42330,P17516 98 5.49e-06 22 2 2 1.000 0.091 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 P42330,P17516 98 5.49e-06 17 2 2 1.000 0.118 REAC:193368 rea 1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1 P42330,P17516 98 9.64e-06 29 2 2 1.000 0.069 GO:0016620 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1 P42330,P17516 98 1.03e-05 30 2 2 1.000 0.067 GO:0019748 BP 1 secondary metabolic process 1 P42330,P17516 98 1.11e-05 24 2 2 1.000 0.083 REAC:192105 rea 1 Synthesis of bile acids and bile salts 1 P42330,P17516 98 1.52e-05 28 2 2 1.000 0.071 REAC:194068 rea 1 Bile acid and bile salt metabolism 1 P42330,P17516 98 2.04e-05 42 2 2 1.000 0.048 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P42330,P17516 98 2.13e-05 33 2 2 1.000 0.061 REAC:975634 rea 1 Retinoid metabolism and transport 1 P42330,P17516 98 2.57e-05 47 2 2 1.000 0.043 GO:0001523 BP 1 retinoid metabolic process 1 P42330,P17516 98 2.57e-05 47 2 2 1.000 0.043 GO:0034754 BP 1 cellular hormone metabolic process 1 P42330,P17516 98 2.79e-05 49 2 2 1.000 0.041 GO:0016101 BP 1 diterpenoid metabolic process 1 P42330,P17516 98 3.03e-05 51 2 2 1.000 0.039 GO:0016655 MF 1 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1 P42330,P17516 98 3.31e-05 41 2 2 1.000 0.049 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 P42330,P17516 98 3.40e-05 54 2 2 1.000 0.037 GO:0006721 BP 1 terpenoid metabolic process 1 P42330,P17516 98 5.11e-05 34 2 2 1.000 0.059 KEGG:00140 keg 1 Steroid hormone biosynthesis 1 P42330,P17516 98 5.41e-05 68 2 2 1.000 0.029 GO:0006720 BP 1 isoprenoid metabolic process 1 P42330,P17516 98 6.41e-05 74 2 2 1.000 0.027 GO:0071229 BP 1 cellular response to acid chemical 1 P42330,P17516 98 6.59e-05 75 2 2 1.000 0.027 GO:0006694 BP 1 steroid biosynthetic process 1 P42330,P17516 98 7.13e-05 78 2 2 1.000 0.026 GO:0016651 MF 1 oxidoreductase activity, acting on NAD(P)H 1 P42330,P17516 98 7.50e-05 80 2 2 1.000 0.025 GO:0042445 BP 1 hormone metabolic process 1 P42330,P17516 98 7.63e-05 62 2 2 1.000 0.032 REAC:2187338 rea 1 Visual phototransduction 1 P42330,P17516 98 9.51e-05 90 2 2 1.000 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P42330,P17516 98 1.02e-04 93 2 2 1.000 0.022 GO:0001101 BP 1 response to acid chemical 1 P42330,P17516 98 1.13e-04 98 2 2 1.000 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P42330,P17516 98 1.18e-04 100 2 2 1.000 0.020 GO:0072330 BP 1 monocarboxylic acid biosynthetic process 1 P42330,P17516 98 1.22e-04 102 2 2 1.000 0.020 GO:1901617 BP 1 organic hydroxy compound biosynthetic process 1 P42330,P17516 98 1.37e-04 108 2 2 1.000 0.019 GO:0097164 BP 1 ammonium ion metabolic process 1 P42330,P17516 98 2.31e-04 140 2 2 1.000 0.014 GO:0008202 BP 1 steroid metabolic process 1 P42330,P17516 98 2.38e-04 142 2 2 1.000 0.014 GO:0042180 BP 1 cellular ketone metabolic process 1 P42330,P17516 98 2.74e-04 1 2 1 0.500 1.000 GO:0035410 MF 1 dihydrotestosterone 17-beta-dehydrogenase activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0036131 MF 1 prostaglandin D2 11-ketoreductase activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:1900052 BP 1 regulation of retinoic acid biosynthetic process 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0071276 BP 1 cellular response to cadmium ion 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0047020 MF 1 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0036130 MF 1 prostaglandin H2 endoperoxidase reductase activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0035671 MF 1 enone reductase activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0045703 MF 1 ketoreductase activity 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:1900053 BP 1 negative regulation of retinoic acid biosynthetic process 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0045827 BP 1 negative regulation of isoprenoid metabolic process 1 P42330 98 2.74e-04 1 2 1 0.500 1.000 GO:0047787 MF 1 delta4-3-oxosteroid 5beta-reductase activity 1 P42330 98 3.18e-04 126 2 2 1.000 0.016 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P42330,P17516 98 3.37e-04 169 2 2 1.000 0.012 GO:0046394 BP 1 carboxylic acid biosynthetic process 1 P42330,P17516 98 3.37e-04 169 2 2 1.000 0.012 GO:0016053 BP 1 organic acid biosynthetic process 1 P42330,P17516 98 4.45e-04 194 2 2 1.000 0.010 GO:0010817 BP 1 regulation of hormone levels 1 P42330,P17516 98 5.48e-04 2 2 1 0.500 0.500 GO:0016487 BP 1 farnesol metabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0006714 BP 1 sesquiterpenoid metabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0032351 BP 1 negative regulation of hormone metabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0019747 BP 1 regulation of isoprenoid metabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0046686 BP 1 response to cadmium ion 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0002138 BP 1 retinoic acid biosynthetic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:2000224 BP 1 regulation of testosterone biosynthetic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0016115 BP 1 terpenoid catabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0016107 BP 1 sesquiterpenoid catabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0016488 BP 1 farnesol catabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0016095 BP 1 polyprenol catabolic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0061370 BP 1 testosterone biosynthetic process 1 P42330 98 5.48e-04 2 2 1 0.500 0.500 GO:0045550 MF 1 geranylgeranyl reductase activity 1 P42330 98 6.31e-04 231 2 2 1.000 0.009 GO:1901615 BP 1 organic hydroxy compound metabolic process 1 P42330,P17516 98 8.22e-04 3 2 1 0.500 0.333 GO:0046137 BP 1 negative regulation of vitamin metabolic process 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0034310 BP 1 primary alcohol catabolic process 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0071799 BP 1 cellular response to prostaglandin D stimulus 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0047086 MF 1 ketosteroid monooxygenase activity 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0018636 MF 1 phenanthrene 9,10-monooxygenase activity 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0016102 BP 1 diterpenoid biosynthetic process 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0071798 BP 1 response to prostaglandin D 1 P42330 98 8.22e-04 3 2 1 0.500 0.333 GO:0008300 BP 1 isoprenoid catabolic process 1 P42330 98 8.43e-04 267 2 2 1.000 0.007 GO:0051186 BP 1 cofactor metabolic process 1 P42330,P17516 98 1.06e-03 299 2 2 1.000 0.007 GO:1901657 BP 1 glycosyl compound metabolic process 1 P42330,P17516 98 1.09e-03 304 2 2 1.000 0.007 GO:0044283 BP 1 small molecule biosynthetic process 1 P42330,P17516 98 1.10e-03 4 2 1 0.500 0.250 GO:0016114 BP 1 terpenoid biosynthetic process 1 P42330 98 1.14e-03 311 2 2 1.000 0.006 GO:0032870 BP 1 cellular response to hormone stimulus 1 P42330,P17516 98 1.37e-03 5 2 1 0.500 0.200 GO:0010566 BP 1 regulation of ketone biosynthetic process 1 P42330 98 1.37e-03 5 2 1 0.500 0.200 GO:0015125 MF 1 bile acid transmembrane transporter activity 1 P17516 98 1.37e-03 5 2 1 0.500 0.200 GO:0030656 BP 1 regulation of vitamin metabolic process 1 P42330 98 1.47e-03 352 2 2 1.000 0.006 GO:0009725 BP 1 response to hormone 1 P42330,P17516 98 1.48e-03 353 2 2 1.000 0.006 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P42330,P17516 98 1.59e-03 367 2 2 1.000 0.005 GO:0008610 BP 1 lipid biosynthetic process 1 P42330,P17516 98 1.64e-03 6 2 1 0.500 0.167 GO:0016093 BP 1 polyprenol metabolic process 1 P42330 98 1.64e-03 6 2 1 0.500 0.167 GO:0019371 BP 1 cyclooxygenase pathway 1 P42330 98 1.64e-03 6 2 1 0.500 0.167 GO:0042448 BP 1 progesterone metabolic process 1 P42330 98 1.64e-03 6 2 1 0.500 0.167 GO:2000353 BP 1 positive regulation of endothelial cell apoptotic process 1 P42330 98 1.64e-03 6 2 1 0.500 0.167 GO:0004032 MF 1 alditol:NADP+ 1-oxidoreductase activity 1 P42330 98 1.92e-03 7 2 1 0.500 0.143 GO:0052650 MF 1 NADP-retinol dehydrogenase activity 1 P42330 98 2.19e-03 8 2 1 0.500 0.125 GO:0071379 BP 1 cellular response to prostaglandin stimulus 1 P42330 98 2.19e-03 8 2 1 0.500 0.125 GO:0042574 BP 1 retinal metabolic process 1 P42330 98 2.34e-03 444 2 2 1.000 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P42330,P17516 98 2.46e-03 9 2 1 0.500 0.111 GO:0042573 BP 1 retinoic acid metabolic process 1 P42330 98 2.46e-03 9 2 1 0.500 0.111 GO:0034694 BP 1 response to prostaglandin 1 P42330 98 2.46e-03 9 2 1 0.500 0.111 GO:0048385 BP 1 regulation of retinoic acid receptor signaling pathway 1 P42330 98 2.62e-03 9 2 1 0.500 0.111 REAC:2162123 rea 1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1 P42330 98 2.73e-03 480 2 2 1.000 0.004 GO:0016491 MF 1 oxidoreductase activity 1 P42330,P17516 98 2.74e-03 10 2 1 0.500 0.100 GO:1904037 BP 1 positive regulation of epithelial cell apoptotic process 1 P42330 98 2.74e-03 10 2 1 0.500 0.100 GO:0071384 BP 1 cellular response to corticosteroid stimulus 1 P42330 98 3.01e-03 11 2 1 0.500 0.091 GO:0032350 BP 1 regulation of hormone metabolic process 1 P42330 98 3.01e-03 11 2 1 0.500 0.091 GO:0070293 BP 1 renal absorption 1 P42330 98 3.29e-03 12 2 1 0.500 0.083 GO:0008209 BP 1 androgen metabolic process 1 P17516 98 3.29e-03 12 2 1 0.500 0.083 GO:0001516 BP 1 prostaglandin biosynthetic process 1 P42330 98 3.29e-03 12 2 1 0.500 0.083 GO:0046457 BP 1 prostanoid biosynthetic process 1 P42330 98 3.29e-03 12 2 1 0.500 0.083 GO:0004745 MF 1 retinol dehydrogenase activity 1 P42330 98 3.56e-03 13 2 1 0.500 0.077 GO:0008106 MF 1 alcohol dehydrogenase (NADP+) activity 1 P42330 98 3.56e-03 13 2 1 0.500 0.077 GO:0015721 BP 1 bile acid and bile salt transport 1 P17516 98 3.56e-03 13 2 1 0.500 0.077 GO:0008299 BP 1 isoprenoid biosynthetic process 1 P42330 98 3.83e-03 14 2 1 0.500 0.071 GO:0071398 BP 1 cellular response to fatty acid 1 P42330 98 4.07e-03 586 2 2 1.000 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 P42330,P17516 98 4.08e-03 14 2 1 0.500 0.071 REAC:5365859 rea 1 RA biosynthesis pathway 1 P42330 98 4.11e-03 15 2 1 0.500 0.067 GO:0070542 BP 1 response to fatty acid 1 P42330 98 4.11e-03 15 2 1 0.500 0.067 GO:0042181 BP 1 ketone biosynthetic process 1 P42330 98 4.11e-03 15 2 1 0.500 0.067 GO:0048384 BP 1 retinoic acid receptor signaling pathway 1 P42330 98 4.38e-03 16 2 1 0.500 0.062 GO:0006699 BP 1 bile acid biosynthetic process 1 P17516 98 4.38e-03 16 2 1 0.500 0.062 GO:0006692 BP 1 prostanoid metabolic process 1 P42330 98 4.38e-03 16 2 1 0.500 0.062 GO:0006693 BP 1 prostaglandin metabolic process 1 P42330 98 4.61e-03 10 2 1 0.500 0.100 KEGG:00120 keg 1 Primary bile acid biosynthesis 1 P17516 98 4.65e-03 17 2 1 0.500 0.059 GO:0008028 MF 1 monocarboxylic acid transmembrane transporter activity 1 P17516 98 4.65e-03 17 2 1 0.500 0.059 GO:0008207 BP 1 C21-steroid hormone metabolic process 1 P42330 98 4.65e-03 17 2 1 0.500 0.059 GO:0016628 MF 1 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1 P42330 98 4.75e-03 633 2 2 1.000 0.003 GO:0044255 BP 1 cellular lipid metabolic process 1 P42330,P17516 98 4.90e-03 643 2 2 1.000 0.003 GO:0071495 BP 1 cellular response to endogenous stimulus 1 P42330,P17516 98 4.93e-03 18 2 1 0.500 0.056 GO:0031960 BP 1 response to corticosteroid 1 P42330 98 5.01e-03 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 P42330,P17516 98 5.20e-03 19 2 1 0.500 0.053 GO:1901570 BP 1 fatty acid derivative biosynthetic process 1 P42330 98 5.20e-03 19 2 1 0.500 0.053 GO:0046456 BP 1 icosanoid biosynthetic process 1 P42330 98 5.47e-03 20 2 1 0.500 0.050 GO:0034308 BP 1 primary alcohol metabolic process 1 P42330 98 5.75e-03 21 2 1 0.500 0.048 GO:0016709 MF 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1 P42330 98 5.75e-03 21 2 1 0.500 0.048 GO:0050810 BP 1 regulation of steroid biosynthetic process 1 P42330 98 5.75e-03 21 2 1 0.500 0.048 GO:2000351 BP 1 regulation of endothelial cell apoptotic process 1 P42330 98 5.75e-03 21 2 1 0.500 0.048 GO:0046164 BP 1 alcohol catabolic process 1 P42330 98 5.75e-03 21 2 1 0.500 0.048 GO:0008206 BP 1 bile acid metabolic process 1 P17516 98 6.01e-03 712 2 2 1.000 0.003 GO:0009719 BP 1 response to endogenous stimulus 1 P42330,P17516 98 6.29e-03 23 2 1 0.500 0.043 GO:1901618 MF 1 organic hydroxy compound transmembrane transporter activity 1 P17516 98 6.30e-03 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 P42330,P17516 98 6.48e-03 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 P42330,P17516 98 6.57e-03 24 2 1 0.500 0.042 GO:0046546 BP 1 development of primary male sexual characteristics 1 P42330 98 6.57e-03 24 2 1 0.500 0.042 GO:0008584 BP 1 male gonad development 1 P42330 98 6.84e-03 25 2 1 0.500 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 P42330 98 6.84e-03 25 2 1 0.500 0.040 GO:0072577 BP 1 endothelial cell apoptotic process 1 P42330 98 6.94e-03 765 2 2 1.000 0.003 GO:0006629 BP 1 lipid metabolic process 1 P42330,P17516 98 7.11e-03 26 2 1 0.500 0.038 GO:1901616 BP 1 organic hydroxy compound catabolic process 1 P42330 98 7.11e-03 26 2 1 0.500 0.038 GO:0000060 BP 1 protein import into nucleus, translocation 1 P42330 98 7.11e-03 26 2 1 0.500 0.038 GO:0046661 BP 1 male sex differentiation 1 P42330 98 7.11e-03 26 2 1 0.500 0.038 GO:0071277 BP 1 cellular response to calcium ion 1 P42330 98 7.11e-03 26 2 1 0.500 0.038 GO:0007584 BP 1 response to nutrient 1 P42330 98 7.39e-03 606 2 2 1.000 0.003 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 P42330,P17516 98 7.55e-03 798 2 2 1.000 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P42330,P17516 98 7.66e-03 28 2 1 0.500 0.036 GO:0006636 BP 1 unsaturated fatty acid biosynthetic process 1 P42330 98 8.21e-03 30 2 1 0.500 0.033 GO:0019369 BP 1 arachidonic acid metabolic process 1 P42330 98 8.59e-03 851 2 2 1.000 0.002 GO:0044711 BP 1 single-organism biosynthetic process 1 P42330,P17516 98 9.03e-03 33 2 1 0.500 0.030 GO:1904035 BP 1 regulation of epithelial cell apoptotic process 1 P42330 98 9.30e-03 34 2 1 0.500 0.029 GO:0019218 BP 1 regulation of steroid metabolic process 1 P42330 98 9.31e-03 32 2 1 0.500 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 P42330 98 9.89e-03 34 2 1 0.500 0.029 REAC:5362517 rea 1 Signaling by Retinoic Acid 1 P42330 98 1.01e-02 37 2 1 0.500 0.027 GO:0051897 BP 1 positive regulation of protein kinase B signaling 1 P42330 98 1.04e-02 38 2 1 0.500 0.026 GO:1904019 BP 1 epithelial cell apoptotic process 1 P42330 98 1.09e-02 40 2 1 0.500 0.025 GO:0045833 BP 1 negative regulation of lipid metabolic process 1 P42330 98 1.15e-02 42 2 1 0.500 0.024 GO:0030216 BP 1 keratinocyte differentiation 1 P42330 98 1.15e-02 42 2 1 0.500 0.024 GO:0008406 BP 1 gonad development 1 P42330 98 1.18e-02 43 2 1 0.500 0.023 GO:0045137 BP 1 development of primary sexual characteristics 1 P42330 98 1.23e-02 45 2 1 0.500 0.022 GO:0071248 BP 1 cellular response to metal ion 1 P42330 98 1.23e-02 45 2 1 0.500 0.022 GO:2000379 BP 1 positive regulation of reactive oxygen species metabolic process 1 P42330 98 1.23e-02 45 2 1 0.500 0.022 GO:0016627 MF 1 oxidoreductase activity, acting on the CH-CH group of donors 1 P42330 98 1.28e-02 47 2 1 0.500 0.021 GO:0004497 MF 1 monooxygenase activity 1 P42330 98 1.29e-02 381 2 2 1.000 0.005 TF:M00132_1 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 1 1 P42330,P17516 98 1.37e-02 50 2 1 0.500 0.020 GO:0006690 BP 1 icosanoid metabolic process 1 P42330 98 1.37e-02 50 2 1 0.500 0.020 GO:1901568 BP 1 fatty acid derivative metabolic process 1 P42330 98 1.48e-02 54 2 1 0.500 0.019 GO:0051592 BP 1 response to calcium ion 1 P42330 98 1.50e-02 55 2 1 0.500 0.018 GO:0003014 BP 1 renal system process 1 P42330 98 1.52e-02 33 2 1 0.500 0.030 KEGG:04913 keg 1 Ovarian steroidogenesis 1 P42330 98 1.53e-02 56 2 1 0.500 0.018 GO:0001676 BP 1 long-chain fatty acid metabolic process 1 P42330 98 1.56e-02 57 2 1 0.500 0.018 GO:0071241 BP 1 cellular response to inorganic substance 1 P42330 98 1.58e-02 58 2 1 0.500 0.017 GO:0009913 BP 1 epidermal cell differentiation 1 P42330 98 1.59e-02 1157 2 2 1.000 0.002 GO:0071310 BP 1 cellular response to organic substance 1 P42330,P17516 98 1.64e-02 60 2 1 0.500 0.017 GO:0007548 BP 1 sex differentiation 1 P42330 98 1.64e-02 60 2 1 0.500 0.017 GO:0051896 BP 1 regulation of protein kinase B signaling 1 P42330 98 1.65e-02 36 2 1 0.500 0.028 KEGG:00590 keg 1 Arachidonic acid metabolism 1 P42330 98 1.72e-02 63 2 1 0.500 0.016 GO:0015718 BP 1 monocarboxylic acid transport 1 P17516 98 1.78e-02 65 2 1 0.500 0.015 GO:0034614 BP 1 cellular response to reactive oxygen species 1 P42330 98 1.78e-02 65 2 1 0.500 0.015 GO:0006633 BP 1 fatty acid biosynthetic process 1 P42330 98 1.80e-02 66 2 1 0.500 0.015 GO:0009267 BP 1 cellular response to starvation 1 P42330 98 1.80e-02 66 2 1 0.500 0.015 GO:0033559 BP 1 unsaturated fatty acid metabolic process 1 P42330 98 1.81e-02 8 2 1 0.500 0.125 TF:M07298_1 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 1 P42330 98 1.83e-02 67 2 1 0.500 0.015 GO:0043491 BP 1 protein kinase B signaling 1 P42330 98 1.86e-02 68 2 1 0.500 0.015 GO:0046890 BP 1 regulation of lipid biosynthetic process 1 P42330 98 1.88e-02 69 2 1 0.500 0.014 GO:0044259 BP 1 multicellular organismal macromolecule metabolic process 1 P42330 98 1.94e-02 71 2 1 0.500 0.014 GO:0006081 BP 1 cellular aldehyde metabolic process 1 P42330 98 1.97e-02 72 2 1 0.500 0.014 GO:0042594 BP 1 response to starvation 1 P42330 98 1.97e-02 72 2 1 0.500 0.014 GO:0044236 BP 1 multicellular organism metabolic process 1 P42330 98 1.97e-02 72 2 1 0.500 0.014 GO:0009055 MF 1 electron carrier activity 1 P17516 98 1.97e-02 72 2 1 0.500 0.014 GO:0005319 MF 1 lipid transporter activity 1 P17516 98 2.00e-02 2 2 1 0.500 0.500 OMIM:614279 omi 1 46,XY SEX REVERSAL 8; SRXY8;;MALE PSEUDOHERMAPHRODITISM DUE TO DEFICIENCY OF TESTICULAR 17,20-DESMOLASE;TDD 1 P17516 98 2.02e-02 74 2 1 0.500 0.014 GO:0046943 MF 1 carboxylic acid transmembrane transporter activity 1 P17516 98 2.05e-02 75 2 1 0.500 0.013 GO:0005342 MF 1 organic acid transmembrane transporter activity 1 P17516 98 2.11e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P42330,P17516 98 2.13e-02 78 2 1 0.500 0.013 GO:2000377 BP 1 regulation of reactive oxygen species metabolic process 1 P42330 98 2.13e-02 78 2 1 0.500 0.013 GO:0043588 BP 1 skin development 1 P42330 98 2.24e-02 82 2 1 0.500 0.012 GO:0048608 BP 1 reproductive structure development 1 P42330 98 2.24e-02 82 2 1 0.500 0.012 GO:0061458 BP 1 reproductive system development 1 P42330 98 2.25e-02 1377 2 2 1.000 0.001 GO:0071702 BP 1 organic substance transport 1 P42330,P17516 98 2.27e-02 83 2 1 0.500 0.012 GO:0031669 BP 1 cellular response to nutrient levels 1 P42330 98 2.31e-02 1394 2 2 1.000 0.001 GO:0010033 BP 1 response to organic substance 1 P42330,P17516 98 2.37e-02 87 2 1 0.500 0.011 GO:0016705 MF 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1 P42330 98 2.40e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 P42330,P17516 98 2.48e-02 91 2 1 0.500 0.011 GO:0031668 BP 1 cellular response to extracellular stimulus 1 P42330 98 2.51e-02 92 2 1 0.500 0.011 GO:0006766 BP 1 vitamin metabolic process 1 P42330 98 2.54e-02 1722 2 2 1.000 0.001 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P42330,P17516 98 2.62e-02 96 2 1 0.500 0.010 GO:0008514 MF 1 organic anion transmembrane transporter activity 1 P17516 98 2.62e-02 96 2 1 0.500 0.010 GO:0010038 BP 1 response to metal ion 1 P42330 98 2.66e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 P42330,P17516 98 2.67e-02 98 2 1 0.500 0.010 GO:0000302 BP 1 response to reactive oxygen species 1 P42330 98 2.73e-02 100 2 1 0.500 0.010 GO:0015850 BP 1 organic hydroxy compound transport 1 P17516 98 2.75e-02 101 2 1 0.500 0.010 GO:0008544 BP 1 epidermis development 1 P42330 98 2.94e-02 108 2 1 0.500 0.009 GO:0031667 BP 1 response to nutrient levels 1 P42330 98 2.94e-02 108 2 1 0.500 0.009 GO:0010565 BP 1 regulation of cellular ketone metabolic process 1 P42330 98 2.94e-02 108 2 1 0.500 0.009 GO:0071383 BP 1 cellular response to steroid hormone stimulus 1 P42330 98 3.11e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 P42330,P17516 98 3.24e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 P42330,P17516 98 3.24e-02 119 2 1 0.500 0.008 GO:0009991 BP 1 response to extracellular stimulus 1 P42330 98 3.24e-02 119 2 1 0.500 0.008 GO:0071496 BP 1 cellular response to external stimulus 1 P42330 98 3.30e-02 121 2 1 0.500 0.008 GO:0072593 BP 1 reactive oxygen species metabolic process 1 P42330 98 3.32e-02 122 2 1 0.500 0.008 GO:0034599 BP 1 cellular response to oxidative stress 1 P42330 98 3.41e-02 125 2 1 0.500 0.008 GO:0044242 BP 1 cellular lipid catabolic process 1 P42330 98 3.46e-02 127 2 1 0.500 0.008 GO:0048545 BP 1 response to steroid hormone 1 P42330 98 3.62e-02 133 2 1 0.500 0.008 GO:0046942 BP 1 carboxylic acid transport 1 P17516 98 3.62e-02 133 2 1 0.500 0.008 GO:0015849 BP 1 organic acid transport 1 P17516 98 3.62e-02 16 2 1 0.500 0.062 TF:M01300_1 tf 1 Factor: HMGA2; motif: ATATTSSSSNWWATT; match class: 1 1 P42330 98 3.84e-02 657 2 2 1.000 0.003 TF:M03826_1 tf 1 Factor: HNF-1beta; motif: NNNYAAHCATTAACYN; match class: 1 1 P42330,P17516 98 3.87e-02 142 2 1 0.500 0.007 GO:0016042 BP 1 lipid catabolic process 1 P42330 98 3.89e-02 143 2 1 0.500 0.007 GO:0006869 BP 1 lipid transport 1 P17516 98 3.94e-02 348 2 2 1.000 0.006 MI:hsa-miR-937 mi 1 MI:hsa-miR-937 1 P42330,P17516 98 4.00e-02 147 2 1 0.500 0.007 GO:0019216 BP 1 regulation of lipid metabolic process 1 P42330 98 4.08e-02 150 2 1 0.500 0.007 GO:0003006 BP 1 developmental process involved in reproduction 1 P42330 98 4.20e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 P42330,P17516 98 4.30e-02 158 2 1 0.500 0.006 GO:0006066 BP 1 alcohol metabolic process 1 P42330 98 4.33e-02 159 2 1 0.500 0.006 GO:0030522 BP 1 intracellular receptor signaling pathway 1 P42330 98 4.35e-02 160 2 1 0.500 0.006 GO:0010035 BP 1 response to inorganic substance 1 P42330 98 4.39e-02 703 2 2 1.000 0.003 TF:M03872_1 tf 1 Factor: HNF-1beta; motif: GTTAATYATTAACY; match class: 1 1 P42330,P17516 98 4.39e-02 1924 2 2 1.000 0.001 GO:0065008 BP 1 regulation of biological quality 1 P42330,P17516 98 4.46e-02 164 2 1 0.500 0.006 GO:0010876 BP 1 lipid localization 1 P17516 98 4.53e-02 20 2 1 0.500 0.050 TF:M06147_0 tf 1 Factor: ZNF41; motif: NRATAAATGGGA; match class: 0 1 P17516 98 4.54e-02 167 2 1 0.500 0.006 GO:1902593 BP 1 single-organism nuclear import 1 P42330 98 4.54e-02 167 2 1 0.500 0.006 GO:0006606 BP 1 protein import into nucleus 1 P42330 98 4.54e-02 167 2 1 0.500 0.006 GO:0044744 BP 1 protein targeting to nucleus 1 P42330 98 4.57e-02 168 2 1 0.500 0.006 GO:0008509 MF 1 anion transmembrane transporter activity 1 P17516 98 5.00e-02 10 2 1 0.500 0.100 HP:0012245 hp 1 Sex reversal 1 P17516 98 5.00e-02 392 2 2 1.000 0.005 MI:hsa-miR-190 mi 1 MI:hsa-miR-190 1 P42330,P17516 98 5.00e-02 10 2 1 0.500 0.100 HP:0012244 hp 1 Abnormal sex determination 1 P17516 98 5.00e-02 5 2 1 0.500 0.200 OMIM:400044 omi 1 46,XY Sex Reversal 1 P17516 98 5.00e-02 1575 2 2 1.000 0.001 REAC:162582 rea 1 Signal Transduction 1 P42330,P17516 98 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 P42330,P17516 98 5.00e-02 750 2 2 1.000 0.003 TF:M03821_1 tf 1 Factor: ER-beta; motif: ANNSTGACCYRGNN; match class: 1 1 P42330,P17516 98 5.00e-02 184 2 1 0.500 0.005 GO:0051170 BP 1 nuclear import 1 P42330 99 7.87e-07 5 2 2 1.000 0.400 GO:0032133 CC 1 chromosome passenger complex 1 O15392,Q53HL2 99 1.63e-05 3 2 2 1.000 0.667 CORUM:2582 cor 1 Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) 1 O15392,Q53HL2 99 1.63e-05 3 2 2 1.000 0.667 CORUM:1120 cor 1 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) 1 O15392,Q53HL2 99 3.26e-05 4 2 2 1.000 0.500 CORUM:1119 cor 1 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) 1 O15392,Q53HL2 99 3.26e-05 4 2 2 1.000 0.500 CORUM:1118 cor 1 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) 1 O15392,Q53HL2 99 3.82e-05 44 2 2 1.000 0.045 REAC:4615885 rea 1 SUMOylation of DNA replication proteins 1 O15392,Q53HL2 99 1.96e-04 99 2 2 1.000 0.020 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 O15392,Q53HL2 99 1.96e-04 99 2 2 1.000 0.020 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 O15392,Q53HL2 99 2.20e-04 105 2 2 1.000 0.019 REAC:2990846 rea 1 SUMOylation 1 O15392,Q53HL2 99 2.29e-04 107 2 2 1.000 0.019 REAC:68877 rea 1 Mitotic Prometaphase 1 O15392,Q53HL2 99 2.55e-04 113 2 2 1.000 0.018 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 O15392,Q53HL2 99 3.74e-04 98 2 2 1.000 0.020 GO:0030496 CC 1 midbody 1 O15392,Q53HL2 99 5.20e-04 161 2 2 1.000 0.012 REAC:2467813 rea 1 Separation of Sister Chromatids 1 O15392,Q53HL2 99 5.25e-04 116 2 2 1.000 0.017 GO:0007062 BP 1 sister chromatid cohesion 1 O15392,Q53HL2 99 5.34e-04 117 2 2 1.000 0.017 GO:0005875 CC 1 microtubule associated complex 1 O15392,Q53HL2 99 5.62e-04 120 2 2 1.000 0.017 GO:0016925 BP 1 protein sumoylation 1 O15392,Q53HL2 99 5.71e-04 121 2 2 1.000 0.017 GO:0000775 CC 1 chromosome, centromeric region 1 O15392,Q53HL2 99 5.93e-04 172 2 2 1.000 0.012 REAC:68882 rea 1 Mitotic Anaphase 1 O15392,Q53HL2 99 6.00e-04 173 2 2 1.000 0.012 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 O15392,Q53HL2 99 1.07e-03 231 2 2 1.000 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 O15392,Q53HL2 99 1.29e-03 253 2 2 1.000 0.008 REAC:68886 rea 1 M Phase 1 O15392,Q53HL2 99 1.50e-03 196 2 2 1.000 0.010 GO:0000819 BP 1 sister chromatid segregation 1 O15392,Q53HL2 99 2.00e-03 226 2 2 1.000 0.009 GO:0098813 BP 1 nuclear chromosome segregation 1 O15392,Q53HL2 99 2.07e-03 230 2 2 1.000 0.009 GO:0098687 CC 1 chromosomal region 1 O15392,Q53HL2 99 2.18e-03 236 2 2 1.000 0.008 GO:0007067 BP 1 mitotic nuclear division 1 O15392,Q53HL2 99 2.30e-03 338 2 2 1.000 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 O15392,Q53HL2 99 2.71e-03 263 2 2 1.000 0.008 GO:0007059 BP 1 chromosome segregation 1 O15392,Q53HL2 99 3.43e-03 296 2 2 1.000 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 O15392,Q53HL2 99 3.49e-03 12 2 1 0.500 0.083 REAC:6803205 rea 1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1 O15392 99 3.74e-03 309 2 2 1.000 0.006 GO:0000280 BP 1 nuclear division 1 O15392,Q53HL2 99 4.04e-03 448 2 2 1.000 0.004 REAC:69278 rea 1 Cell Cycle, Mitotic 1 O15392,Q53HL2 99 4.53e-03 340 2 2 1.000 0.006 GO:0048285 BP 1 organelle fission 1 O15392,Q53HL2 99 6.02e-03 547 2 2 1.000 0.004 REAC:1640170 rea 1 Cell Cycle 1 O15392,Q53HL2 99 6.35e-03 7 2 1 0.500 0.143 GO:0097341 BP 1 zymogen inhibition 1 O15392 99 6.35e-03 7 2 1 0.500 0.143 GO:0097340 BP 1 inhibition of cysteine-type endopeptidase activity 1 O15392 99 6.35e-03 7 2 1 0.500 0.143 GO:1990001 BP 1 inhibition of cysteine-type endopeptidase activity involved in apoptotic process 1 O15392 99 7.81e-03 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 O15392,Q53HL2 99 9.60e-03 33 2 1 0.500 0.030 REAC:5633008 rea 1 TP53 Regulates Transcription of Cell Death Genes 1 O15392 99 1.02e-02 712 2 2 1.000 0.003 REAC:597592 rea 1 Post-translational protein modification 1 O15392,Q53HL2 99 1.25e-02 1 2 1 0.500 1.000 CORUM:2580 cor 1 Survivin homodimer complex 1 O15392 99 1.25e-02 565 2 2 1.000 0.004 GO:0044427 CC 1 chromosomal part 1 O15392,Q53HL2 99 1.29e-02 573 2 2 1.000 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 O15392,Q53HL2 99 1.46e-02 609 2 2 1.000 0.003 GO:0005694 CC 1 chromosome 1 O15392,Q53HL2 99 1.54e-02 17 2 1 0.500 0.059 GO:0008536 MF 1 Ran GTPase binding 1 O15392 99 1.70e-02 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 O15392,Q53HL2 99 1.70e-02 1408 2 2 1.000 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 O15392,Q53HL2 99 1.72e-02 662 2 2 1.000 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 O15392,Q53HL2 99 1.72e-02 19 2 1 0.500 0.053 GO:0010955 BP 1 negative regulation of protein processing 1 O15392 99 1.72e-02 19 2 1 0.500 0.053 GO:1903318 BP 1 negative regulation of protein maturation 1 O15392 99 1.76e-02 20 2 1 0.500 0.050 TF:M04026_0 tf 1 Factor: SMAD3; motif: YGTCTAGACA; match class: 0 1 O15392 99 1.96e-02 1513 2 2 1.000 0.001 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 O15392,Q53HL2 99 1.99e-02 22 2 1 0.500 0.045 GO:0051233 CC 1 spindle midzone 1 Q53HL2 99 2.04e-02 720 2 2 1.000 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 O15392,Q53HL2 99 2.04e-02 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 O15392,Q53HL2 99 2.08e-02 23 2 1 0.500 0.043 GO:0000777 CC 1 condensed chromosome kinetochore 1 O15392 99 2.12e-02 30 2 1 0.500 0.033 KEGG:04215 keg 1 Apoptosis - multiple species 1 O15392 99 2.17e-02 1589 2 2 1.000 0.001 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 O15392,Q53HL2 99 2.20e-02 1600 2 2 1.000 0.001 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 O15392,Q53HL2 99 2.32e-02 769 2 2 1.000 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 O15392,Q53HL2 99 2.37e-02 828 2 2 1.000 0.002 TF:M04223_0 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 0 1 O15392,Q53HL2 99 2.50e-02 2 2 1 0.500 0.500 CORUM:1117 cor 1 CRM1-Survivin mitotic complex 1 O15392 99 2.72e-02 31 2 1 0.500 0.032 TF:M06971_0 tf 1 Factor: ZNF521; motif: TGGGGKCCCCCA; match class: 0 1 O15392 99 2.72e-02 1782 2 2 1.000 0.001 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 O15392,Q53HL2 99 2.75e-02 1169 2 2 1.000 0.002 REAC:392499 rea 1 Metabolism of proteins 1 O15392,Q53HL2 99 2.81e-02 31 2 1 0.500 0.032 GO:0000779 CC 1 condensed chromosome, centromeric region 1 O15392 99 3.26e-02 36 2 1 0.500 0.028 GO:0045171 CC 1 intercellular bridge 1 Q53HL2 99 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 O15392,Q53HL2 99 3.42e-02 933 2 2 1.000 0.002 GO:0044430 CC 1 cytoskeletal part 1 O15392,Q53HL2 99 3.56e-02 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 O15392,Q53HL2 99 3.60e-02 41 2 1 0.500 0.024 TF:M05350_0 tf 1 Factor: OZF; motif: KGTTAAAGGARA; match class: 0 1 O15392 99 3.71e-02 41 2 1 0.500 0.024 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q53HL2 99 3.75e-02 3 2 1 0.500 0.333 CORUM:1116 cor 1 CRM1-Survivin-AuroraB mitotic complex 1 O15392 99 3.75e-02 3 2 1 0.500 0.333 CORUM:2579 cor 1 Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) 1 O15392 99 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 O15392,Q53HL2 99 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 O15392,Q53HL2 99 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 O15392,Q53HL2 99 4.08e-02 45 2 1 0.500 0.022 GO:1903317 BP 1 regulation of protein maturation 1 O15392 99 4.08e-02 45 2 1 0.500 0.022 GO:0070613 BP 1 regulation of protein processing 1 O15392 99 4.09e-02 58 2 1 0.500 0.017 KEGG:05210 keg 1 Colorectal cancer 1 O15392 99 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 O15392,Q53HL2 99 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 O15392,Q53HL2 99 4.17e-02 46 2 1 0.500 0.022 GO:0043154 BP 1 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 O15392 99 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 O15392,Q53HL2 99 4.35e-02 48 2 1 0.500 0.021 GO:0051310 BP 1 metaphase plate congression 1 Q53HL2 99 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 O15392,Q53HL2 99 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 O15392,Q53HL2 99 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 O15392,Q53HL2 99 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 O15392,Q53HL2 99 4.80e-02 53 2 1 0.500 0.019 GO:0090307 BP 1 mitotic spindle assembly 1 O15392 99 4.89e-02 54 2 1 0.500 0.019 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 O15392 99 4.98e-02 55 2 1 0.500 0.018 GO:0051303 BP 1 establishment of chromosome localization 1 Q53HL2 99 5.00e-02 4 2 1 0.500 0.250 CORUM:1087 cor 1 BIRC5-AURKB-INCENP-EVI5 complex 1 O15392 99 5.00e-02 4 2 1 0.500 0.250 CORUM:2581 cor 1 RasGAP-AURKA/AURKB-survivin complex 1 O15392 99 5.00e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 O15392,Q53HL2 99 5.00e-02 1575 2 2 1.000 0.001 REAC:162582 rea 1 Signal Transduction 1 O15392,Q53HL2 99 5.00e-02 71 2 1 0.500 0.014 KEGG:01524 keg 1 Platinum drug resistance 1 O15392 99 5.00e-02 57 2 1 0.500 0.018 TF:M05912_0 tf 1 Factor: FLJ20557; motif: NGGKGYTAMASA; match class: 0 1 Q53HL2 100 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-454* mi 1 MI:hsa-miR-454* 1 Q9H6D8 100 4.78e-02 271 2 1 0.500 0.004 MI:hsa-miR-526b* mi 1 MI:hsa-miR-526b* 1 Q6NUK4 100 4.96e-02 281 2 1 0.500 0.004 MI:hsa-miR-144* mi 1 MI:hsa-miR-144* 1 Q9H6D8 100 5.00e-02 458 2 2 1.000 0.004 TF:M04625_1 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 1 1 Q9H6D8,Q6NUK4 100 5.00e-02 10 2 1 0.500 0.100 GO:0007084 BP 1 mitotic nuclear envelope reassembly 1 Q6NUK4 101 9.56e-03 26 2 1 0.500 0.038 REAC:5693554 rea 1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 Q96B01 101 1.07e-02 29 2 1 0.500 0.034 REAC:5693568 rea 1 Resolution of D-loop Structures through Holliday Junction Intermediates 1 Q96B01 101 1.10e-02 30 2 1 0.500 0.033 REAC:5693537 rea 1 Resolution of D-Loop Structures 1 Q96B01 101 1.25e-02 1 2 1 0.500 1.000 OMIM:613227 omi 1 CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME3; CAMRQ3;;CEREBELLAR ATAXIA AND MENTAL RETARDATION WITH OR WITHOUT QUADRUPEDALLOCOMOTION 3 1 P35219 101 1.25e-02 4 2 1 0.500 0.250 HP:0007063 hp 1 Aplasia of the inferior half of the cerebellar vermis 1 P35219 101 1.41e-02 11 2 1 0.500 0.091 GO:0004089 MF 1 carbonate dehydratase activity 1 P35219 101 1.51e-02 41 2 1 0.500 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 Q96B01 101 1.57e-02 5 2 1 0.500 0.200 HP:0007047 hp 1 Atrophy of the dentate nucleus 1 P35219 101 1.93e-02 15 2 1 0.500 0.067 GO:0010569 BP 1 regulation of double-strand break repair via homologous recombination 1 Q96B01 101 2.24e-02 61 2 1 0.500 0.016 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q96B01 101 2.50e-02 8 2 1 0.500 0.125 HP:0007371 hp 1 Corpus callosum atrophy 1 P35219 101 2.82e-02 9 2 1 0.500 0.111 HP:0012762 hp 1 Cerebral white matter atrophy 1 P35219 101 3.34e-02 26 2 1 0.500 0.038 GO:0000732 BP 1 strand displacement 1 Q96B01 101 3.44e-02 11 2 1 0.500 0.091 HP:0001350 hp 1 Slurred speech 1 P35219 101 3.75e-02 12 2 1 0.500 0.083 HP:0002943 hp 1 Thoracic scoliosis 1 P35219 101 3.80e-02 104 2 1 0.500 0.010 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q96B01 101 3.98e-02 31 2 1 0.500 0.032 GO:2000779 BP 1 regulation of double-strand break repair 1 Q96B01 101 4.02e-02 110 2 1 0.500 0.009 REAC:5693538 rea 1 Homology Directed Repair 1 Q96B01 101 4.23e-02 33 2 1 0.500 0.030 GO:0000018 BP 1 regulation of DNA recombination 1 Q96B01 101 4.36e-02 34 2 1 0.500 0.029 GO:0071479 BP 1 cellular response to ionizing radiation 1 Q96B01 101 4.87e-02 38 2 1 0.500 0.026 GO:0036297 BP 1 interstrand cross-link repair 1 Q96B01 101 5.00e-02 137 2 1 0.500 0.007 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 Q96B01 101 5.00e-02 16 2 1 0.500 0.062 HP:0002942 hp 1 Thoracic kyphosis 1 P35219 101 5.00e-02 4 2 1 0.500 0.250 OMIM:224050 omi 1 CAMRQ 1 P35219 101 5.00e-02 39 2 1 0.500 0.026 GO:0016836 MF 1 hydro-lyase activity 1 P35219 101 5.00e-02 14 2 1 0.500 0.071 KEGG:00910 keg 1 Nitrogen metabolism 1 P35219 101 5.00e-02 433 2 2 1.000 0.005 MI:hsa-miR-613 mi 1 MI:hsa-miR-613 1 Q96B01,P35219 101 5.00e-02 309 2 2 1.000 0.006 TF:M02117_1 tf 1 Factor: STAT4; motif: TTMNNRGAAA; match class: 1 1 Q96B01,P35219 102 7.27e-03 42 2 1 0.500 0.024 GO:0005089 MF 1 Rho guanyl-nucleotide exchange factor activity 1 Q96PE2 102 2.50e-02 145 2 1 0.500 0.007 GO:0005088 MF 1 Ras guanyl-nucleotide exchange factor activity 1 Q96PE2 102 2.82e-02 164 2 1 0.500 0.006 GO:0051056 BP 1 regulation of small GTPase mediated signal transduction 1 Q96PE2 102 2.99e-02 46 2 1 0.500 0.022 REAC:193648 rea 1 NRAGE signals death through JNK 1 Q96PE2 102 3.27e-02 190 2 1 0.500 0.005 GO:0005085 MF 1 guanyl-nucleotide exchange factor activity 1 Q96PE2 102 3.84e-02 59 2 1 0.500 0.017 REAC:204998 rea 1 Cell death signalling via NRAGE, NRIF and NADE 1 Q96PE2 102 4.58e-02 267 2 1 0.500 0.004 GO:0007264 BP 1 small GTPase mediated signal transduction 1 Q96PE2 102 4.74e-02 73 2 1 0.500 0.014 REAC:416482 rea 1 G alpha (12/13) signalling events 1 Q96PE2 102 5.00e-02 565 2 2 1.000 0.004 TF:M02261_1 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 1 1 Q9NYN1,Q96PE2 103 1.20e-08 22 8 4 0.500 0.182 REAC:983170 rea 1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1 Q15436,O94979,O95487,P55735 103 3.21e-08 37 8 4 0.500 0.108 GO:0012507 CC 1 ER to Golgi transport vesicle membrane 1 Q15436,O94979,O95487,P55735 103 1.35e-07 160 8 5 0.625 0.031 GO:0030135 CC 1 coated vesicle 1 Q15436,Q01968,O94979,O95487,P55735 103 1.53e-07 54 8 4 0.500 0.074 GO:0048208 BP 1 COPII vesicle coating 1 Q15436,O94979,O95487,P55735 103 1.53e-07 54 8 4 0.500 0.074 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 Q15436,O94979,O95487,P55735 103 1.53e-07 54 8 4 0.500 0.074 GO:0030134 CC 1 ER to Golgi transport vesicle 1 Q15436,O94979,O95487,P55735 103 1.78e-07 56 8 4 0.500 0.071 GO:0006901 BP 1 vesicle coating 1 Q15436,O94979,O95487,P55735 103 1.91e-07 57 8 4 0.500 0.070 GO:0090114 BP 1 COPII-coated vesicle budding 1 Q15436,O94979,O95487,P55735 103 2.20e-07 59 8 4 0.500 0.068 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 Q15436,O94979,O95487,P55735 103 3.70e-07 67 8 4 0.500 0.060 GO:0006903 BP 1 vesicle targeting 1 Q15436,O94979,O95487,P55735 103 5.24e-07 73 8 4 0.500 0.055 GO:0030658 CC 1 transport vesicle membrane 1 Q15436,O94979,O95487,P55735 103 6.17e-07 76 8 4 0.500 0.053 GO:0002474 BP 1 antigen processing and presentation of peptide antigen via MHC class I 1 Q15436,O94979,O95487,P55735 103 7.85e-07 60 8 4 0.500 0.067 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 Q15436,O94979,O95487,P55735 103 7.99e-07 81 8 4 0.500 0.049 GO:0019886 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class II 1 Q15436,O94979,O95487,P55735 103 8.40e-07 82 8 4 0.500 0.049 GO:0002495 BP 1 antigen processing and presentation of peptide antigen via MHC class II 1 Q15436,O94979,O95487,P55735 103 8.82e-07 83 8 4 0.500 0.048 GO:0002504 BP 1 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1 Q15436,O94979,O95487,P55735 103 1.59e-06 96 8 4 0.500 0.042 GO:0006900 BP 1 membrane budding 1 Q15436,O94979,O95487,P55735 103 1.66e-06 97 8 4 0.500 0.041 GO:0030662 CC 1 coated vesicle membrane 1 Q15436,O94979,O95487,P55735 103 5.05e-06 95 8 4 0.500 0.042 REAC:2132295 rea 1 MHC class II antigen presentation 1 Q15436,O94979,O95487,P55735 103 7.89e-06 143 8 4 0.500 0.028 GO:0002478 BP 1 antigen processing and presentation of exogenous peptide antigen 1 Q15436,O94979,O95487,P55735 103 8.11e-06 144 8 4 0.500 0.028 GO:0019884 BP 1 antigen processing and presentation of exogenous antigen 1 Q15436,O94979,O95487,P55735 103 9.55e-06 150 8 4 0.500 0.027 GO:0048002 BP 1 antigen processing and presentation of peptide antigen 1 Q15436,O94979,O95487,P55735 103 1.03e-05 153 8 4 0.500 0.026 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 Q15436,O94979,O95487,P55735 103 1.25e-05 119 8 4 0.500 0.034 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 Q15436,O94979,O95487,P55735 103 1.43e-05 166 8 4 0.500 0.024 GO:0051650 BP 1 establishment of vesicle localization 1 Q15436,O94979,O95487,P55735 103 1.69e-05 173 8 4 0.500 0.023 GO:0019882 BP 1 antigen processing and presentation 1 Q15436,O94979,O95487,P55735 103 1.77e-05 175 8 4 0.500 0.023 GO:0051648 BP 1 vesicle localization 1 Q15436,O94979,O95487,P55735 103 2.52e-05 142 8 4 0.500 0.028 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 Q15436,O94979,O95487,P55735 103 2.56e-05 192 8 4 0.500 0.021 GO:0030133 CC 1 transport vesicle 1 Q15436,O94979,O95487,P55735 103 6.08e-05 8 8 2 0.250 0.250 GO:0045095 CC 1 keratin filament 1 P48729,Q6ZRV2 103 6.72e-05 245 8 4 0.500 0.016 GO:0030659 CC 1 cytoplasmic vesicle membrane 1 Q15436,O94979,O95487,P55735 103 7.87e-05 255 8 4 0.500 0.016 GO:0012506 CC 1 vesicle membrane 1 Q15436,O94979,O95487,P55735 103 1.11e-04 278 8 4 0.500 0.014 GO:0048193 BP 1 Golgi vesicle transport 1 Q15436,O94979,O95487,P55735 103 1.15e-04 281 8 4 0.500 0.014 GO:0016050 BP 1 vesicle organization 1 Q15436,O94979,O95487,P55735 103 1.29e-04 289 8 4 0.500 0.014 GO:0051656 BP 1 establishment of organelle localization 1 Q15436,O94979,O95487,P55735 103 2.20e-04 331 8 4 0.500 0.012 GO:0051640 BP 1 organelle localization 1 Q15436,O94979,O95487,P55735 103 2.28e-04 248 8 4 0.500 0.016 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q15436,O94979,O95487,P55735 103 2.41e-04 522 8 5 0.625 0.010 REAC:199991 rea 1 Membrane Trafficking 1 Q15436,Q01968,O94979,O95487,P55735 103 2.80e-04 749 8 5 0.625 0.007 GO:0061024 BP 1 membrane organization 1 Q15436,O94979,O95487,P55735,Q9Y446 103 3.07e-04 549 8 5 0.625 0.009 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q15436,Q01968,O94979,O95487,P55735 103 4.54e-04 21 8 2 0.250 0.095 GO:0045104 BP 1 intermediate filament cytoskeleton organization 1 P48729,Q6ZRV2 103 4.54e-04 21 8 2 0.250 0.095 GO:0045103 BP 1 intermediate filament-based process 1 P48729,Q6ZRV2 103 4.92e-04 842 8 5 0.625 0.006 GO:0070271 BP 1 protein complex biogenesis 1 Q15436,P48729,O94979,O95487,P55735 103 4.92e-04 842 8 5 0.625 0.006 GO:0006461 BP 1 protein complex assembly 1 Q15436,P48729,O94979,O95487,P55735 103 6.29e-04 322 8 4 0.500 0.012 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q15436,O94979,O95487,P55735 103 7.15e-04 910 8 5 0.625 0.005 GO:0097708 CC 1 intracellular vesicle 1 Q15436,Q01968,O94979,O95487,P55735 103 7.98e-04 931 8 5 0.625 0.005 GO:0031410 CC 1 cytoplasmic vesicle 1 Q15436,Q01968,O94979,O95487,P55735 103 9.15e-04 958 8 5 0.625 0.005 GO:0016192 BP 1 vesicle-mediated transport 1 Q15436,P48729,O94979,O95487,P55735 103 9.94e-04 27 8 2 0.250 0.074 REAC:5694530 rea 1 Cargo concentration in the ER 1 Q15436,O95487 103 1.09e-03 499 8 4 0.500 0.008 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q15436,O94979,O95487,P55735 103 1.15e-03 1706 8 6 0.750 0.004 GO:0022607 BP 1 cellular component assembly 1 Q15436,P48729,O94979,O95487,P55735,Q9Y446 103 1.21e-03 1015 8 5 0.625 0.005 GO:0071822 BP 1 protein complex subunit organization 1 Q15436,P48729,O94979,O95487,P55735 103 1.36e-03 528 8 4 0.500 0.008 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q15436,O94979,O95487,P55735 103 1.42e-03 534 8 4 0.500 0.007 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q15436,O94979,O95487,P55735 103 1.75e-03 1836 8 6 0.750 0.003 GO:0051641 BP 1 cellular localization 1 Q15436,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 1.87e-03 1113 8 5 0.625 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 Q15436,P48729,O94979,O95487,P55735 103 2.03e-03 44 8 2 0.250 0.045 GO:0005882 CC 1 intermediate filament 1 P48729,Q6ZRV2 103 2.33e-03 1932 8 6 0.750 0.003 GO:0044085 BP 1 cellular component biogenesis 1 Q15436,P48729,O94979,O95487,P55735,Q9Y446 103 3.16e-03 658 8 4 0.500 0.006 GO:0044432 CC 1 endoplasmic reticulum part 1 Q15436,O94979,O95487,P55735 103 3.43e-03 50 8 2 0.250 0.040 REAC:1655829 rea 1 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1 Q15436,O95487 103 3.89e-03 487 8 3 0.375 0.006 MI:hsa-miR-520h mi 1 MI:hsa-miR-520h 1 P48729,Q01968,P55735 103 4.19e-03 500 8 3 0.375 0.006 MI:hsa-miR-519e mi 1 MI:hsa-miR-519e 1 P48729,O95487,P55735 103 5.43e-03 759 8 4 0.500 0.005 GO:0098805 CC 1 whole membrane 1 Q15436,O94979,O95487,P55735 103 5.68e-03 2262 8 6 0.750 0.003 GO:0006996 BP 1 organelle organization 1 Q15436,P48729,O94979,O95487,P55735,Q6ZRV2 103 5.92e-03 3401 8 7 0.875 0.002 GO:0051179 BP 1 localization 1 Q15436,P48729,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 7.33e-03 614 8 4 0.500 0.007 REAC:1280218 rea 1 Adaptive Immune System 1 Q15436,O94979,O95487,P55735 103 7.37e-03 84 8 2 0.250 0.024 GO:0045111 CC 1 intermediate filament cytoskeleton 1 P48729,Q6ZRV2 103 1.07e-02 1614 8 5 0.625 0.003 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q15436,P48729,O94979,O95487,P55735 103 1.08e-02 3 8 1 0.125 0.333 GO:1904424 BP 1 regulation of GTP binding 1 P48729 103 1.08e-02 3 8 1 0.125 0.333 GO:1990254 MF 1 keratin filament binding 1 Q6ZRV2 103 1.18e-02 933 8 4 0.500 0.004 GO:0005783 CC 1 endoplasmic reticulum 1 Q15436,O94979,O95487,P55735 103 1.24e-02 945 8 4 0.500 0.004 GO:0098588 CC 1 bounding membrane of organelle 1 Q15436,O94979,O95487,P55735 103 1.27e-02 712 8 4 0.500 0.006 REAC:597592 rea 1 Post-translational protein modification 1 Q15436,O94979,O95487,P55735 103 1.42e-02 3882 8 7 0.875 0.002 GO:0016043 BP 1 cellular component organization 1 Q15436,P48729,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 1.43e-02 4 8 1 0.125 0.250 GO:0002159 BP 1 desmosome assembly 1 Q9Y446 103 1.43e-02 4 8 1 0.125 0.250 GO:0052658 MF 1 inositol-1,4,5-trisphosphate 5-phosphatase activity 1 Q01968 103 1.54e-02 2707 8 6 0.750 0.002 GO:0005829 CC 1 cytosol 1 Q15436,P48729,Q01968,O94979,O95487,P55735 103 1.67e-02 2748 8 6 0.750 0.002 GO:0051234 BP 1 establishment of localization 1 Q15436,P48729,O94979,O95487,P55735,Q9Y446 103 1.69e-02 290 8 2 0.250 0.007 MI:hsa-miR-132* mi 1 MI:hsa-miR-132* 1 P55735,Q6ZRV2 103 1.77e-02 4013 8 7 0.875 0.002 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q15436,P48729,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 1.79e-02 5 8 1 0.125 0.200 GO:0030127 CC 1 COPII vesicle coat 1 O94979 103 1.79e-02 5 8 1 0.125 0.200 GO:1904885 BP 1 beta-catenin destruction complex assembly 1 P48729 103 2.07e-02 323 8 2 0.250 0.006 MI:hsa-miR-488* mi 1 MI:hsa-miR-488* 1 P48729,P55735 103 2.13e-02 867 8 3 0.375 0.003 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 Q01968,O94979,Q9Y446 103 2.15e-02 6 8 1 0.125 0.167 GO:0052659 MF 1 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity 1 Q01968 103 2.15e-02 6 8 1 0.125 0.167 GO:0002934 BP 1 desmosome organization 1 Q9Y446 103 2.23e-02 336 8 2 0.250 0.006 MI:hsa-miR-508-5p mi 1 MI:hsa-miR-508-5p 1 Q6ZRV2,Q9Y446 103 2.32e-02 343 8 2 0.250 0.006 MI:mmu-miR-711 mi 1 MI:mmu-miR-711 1 P55735,Q6ZRV2 103 2.50e-02 1 8 1 0.125 1.000 OMIM:130900 omi 1 AMELOGENESIS IMPERFECTA, TYPE III; AI3;;AMELOGENESIS IMPERFECTA, HYPOCALCIFICATION TYPE, AUTOSOMAL DOMINANT;ADHCAI;;AMELOGENESIS IMPERFECTA, HYPOMINERALIZATION TYPE 1 Q6ZRV2 103 2.50e-02 1 8 1 0.125 1.000 OMIM:309000 omi 1 LOWE OCULOCEREBRORENAL SYNDROME; OCRL;;OCRL1;;LOWE SYNDROME;;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE DEFICIENCY 1 Q01968 103 2.50e-02 1 8 1 0.125 1.000 OMIM:607812 omi 1 CRANIOLENTICULOSUTURAL DYSPLASIA; CLSD;;BOYADJIEV-JABS SYNDROME 1 Q15436 103 2.50e-02 1 8 1 0.125 1.000 OMIM:300555 omi 1 DENT DISEASE 2 1 Q01968 103 2.51e-02 7 8 1 0.125 0.143 GO:0045294 MF 1 alpha-catenin binding 1 Q9Y446 103 2.51e-02 7 8 1 0.125 0.143 GO:0004439 MF 1 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1 Q01968 103 2.68e-02 1165 8 4 0.500 0.003 GO:0002376 BP 1 immune system process 1 Q15436,O94979,O95487,P55735 103 2.75e-02 376 8 2 0.250 0.005 MI:mmu-miR-687 mi 1 MI:mmu-miR-687 1 P48729,Q9Y446 103 2.86e-02 8 8 1 0.125 0.125 GO:0019215 MF 1 intermediate filament binding 1 Q6ZRV2 103 2.86e-02 8 8 1 0.125 0.125 GO:0052743 MF 1 inositol tetrakisphosphate phosphatase activity 1 Q01968 103 2.95e-02 390 8 2 0.250 0.005 MI:hsa-miR-154 mi 1 MI:hsa-miR-154 1 P48729,O95487 103 2.95e-02 10 8 1 0.125 0.100 REAC:1855183 rea 1 Synthesis of IP2, IP, and Ins in the cytosol 1 Q01968 103 3.09e-02 1804 8 4 0.500 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q01968,P55735,Q6ZRV2,Q9Y446 103 3.09e-02 400 8 2 0.250 0.005 MI:hsa-miR-601 mi 1 MI:hsa-miR-601 1 P48729,Q9Y446 103 3.12e-02 402 8 2 0.250 0.005 MI:mmu-miR-546 mi 1 MI:mmu-miR-546 1 Q6ZRV2,Q9Y446 103 3.18e-02 406 8 2 0.250 0.005 MI:mmu-miR-680 mi 1 MI:mmu-miR-680 1 O95487,P55735 103 3.21e-02 2805 8 5 0.625 0.002 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 Q01968,O94979,O95487,Q6ZRV2,Q9Y446 103 3.31e-02 415 8 2 0.250 0.005 MI:hsa-miR-491-5p mi 1 MI:hsa-miR-491-5p 1 P48729,P55735 103 3.34e-02 1237 8 4 0.500 0.003 GO:0046907 BP 1 intracellular transport 1 Q15436,O94979,O95487,P55735 103 3.41e-02 422 8 2 0.250 0.005 MI:hsa-miR-598 mi 1 MI:hsa-miR-598 1 O95487,Q9Y446 103 3.47e-02 426 8 2 0.250 0.005 MI:mmu-miR-471 mi 1 MI:mmu-miR-471 1 P48729,P55735 103 3.54e-02 12 8 1 0.125 0.083 REAC:5635838 rea 1 Activation of SMO 1 P48729 103 3.58e-02 10 8 1 0.125 0.100 GO:0061700 CC 1 GATOR2 complex 1 P55735 103 3.58e-02 10 8 1 0.125 0.100 GO:0031080 CC 1 nuclear pore outer ring 1 P55735 103 3.58e-02 10 8 1 0.125 0.100 GO:0046030 MF 1 inositol trisphosphate phosphatase activity 1 Q01968 103 3.59e-02 434 8 2 0.250 0.005 MI:mmu-miR-434-3p mi 1 MI:mmu-miR-434-3p 1 P48729,Q9Y446 103 3.79e-02 447 8 2 0.250 0.004 MI:hsa-miR-502-5p mi 1 MI:hsa-miR-502-5p 1 Q6ZRV2,Q9Y446 103 3.81e-02 448 8 2 0.250 0.004 MI:hsa-miR-30c-2* mi 1 MI:hsa-miR-30c-2* 1 O94979,P55735 103 3.91e-02 6266 8 8 1.000 0.001 GO:0044763 BP 1 single-organism cellular process 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 3.93e-02 11 8 1 0.125 0.091 GO:0070971 CC 1 endoplasmic reticulum exit site 1 O94979 103 4.12e-02 14 8 1 0.125 0.071 REAC:5467340 rea 1 AXIN missense mutants destabilize the destruction complex 1 P48729 103 4.12e-02 14 8 1 0.125 0.071 REAC:4839744 rea 1 truncated APC mutants destabilize the destruction complex 1 P48729 103 4.12e-02 14 8 1 0.125 0.071 REAC:5467337 rea 1 APC truncation mutants have impaired AXIN binding 1 P48729 103 4.12e-02 14 8 1 0.125 0.071 REAC:5467348 rea 1 Truncations of AMER1 destabilize the destruction complex 1 P48729 103 4.12e-02 14 8 1 0.125 0.071 REAC:4839748 rea 1 AMER1 mutants destabilize the destruction complex 1 P48729 103 4.12e-02 14 8 1 0.125 0.071 REAC:4839735 rea 1 AXIN mutants destabilize the destruction complex, activating WNT signaling 1 P48729 103 4.19e-02 472 8 2 0.250 0.004 MI:hsa-miR-525-5p mi 1 MI:hsa-miR-525-5p 1 Q6ZRV2,Q9Y446 103 4.19e-02 472 8 2 0.250 0.004 MI:hsa-miR-515-3p mi 1 MI:hsa-miR-515-3p 1 O95487,P55735 103 4.28e-02 6336 8 8 1.000 0.001 GO:0005515 MF 1 protein binding 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 4.29e-02 12 8 1 0.125 0.083 GO:0034595 MF 1 phosphatidylinositol phosphate 5-phosphatase activity 1 Q01968 103 4.31e-02 4600 8 7 0.875 0.002 GO:0016020 CC 1 membrane 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q9Y446 103 4.36e-02 482 8 2 0.250 0.004 MI:mmu-miR-464 mi 1 MI:mmu-miR-464 1 P48729,Q9Y446 103 4.36e-02 482 8 2 0.250 0.004 MI:hsa-miR-191 mi 1 MI:hsa-miR-191 1 O95487,P55735 103 4.42e-02 15 8 1 0.125 0.067 REAC:1660514 rea 1 Synthesis of PIPs at the Golgi membrane 1 Q01968 103 4.42e-02 15 8 1 0.125 0.067 REAC:5339716 rea 1 Misspliced GSK3beta mutants stabilize beta-catenin 1 P48729 103 4.42e-02 15 8 1 0.125 0.067 REAC:5358752 rea 1 T41 mutants of beta-catenin aren't phosphorylated 1 P48729 103 4.42e-02 15 8 1 0.125 0.067 REAC:4839743 rea 1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1 P48729 103 4.42e-02 15 8 1 0.125 0.067 REAC:5358751 rea 1 S45 mutants of beta-catenin aren't phosphorylated 1 P48729 103 4.42e-02 15 8 1 0.125 0.067 REAC:5358749 rea 1 S37 mutants of beta-catenin aren't phosphorylated 1 P48729 103 4.42e-02 15 8 1 0.125 0.067 REAC:5358747 rea 1 S33 mutants of beta-catenin aren't phosphorylated 1 P48729 103 4.46e-02 488 8 2 0.250 0.004 MI:hsa-miR-520g mi 1 MI:hsa-miR-520g 1 P48729,Q01968 103 4.64e-02 499 8 2 0.250 0.004 MI:mmu-miR-673-3p mi 1 MI:mmu-miR-673-3p 1 P55735,Q6ZRV2 103 4.64e-02 13 8 1 0.125 0.077 GO:0030877 CC 1 beta-catenin destruction complex 1 P48729 103 4.64e-02 13 8 1 0.125 0.077 GO:0005847 CC 1 mRNA cleavage and polyadenylation specificity factor complex 1 P48729 103 4.74e-02 505 8 2 0.250 0.004 MI:hsa-miR-519d mi 1 MI:hsa-miR-519d 1 P48729,Q01968 103 4.74e-02 505 8 2 0.250 0.004 MI:hsa-miR-367 mi 1 MI:hsa-miR-367 1 P48729,Q6ZRV2 103 4.76e-02 506 8 2 0.250 0.004 MI:hsa-miR-221 mi 1 MI:hsa-miR-221 1 P48729,O95487 103 4.78e-02 507 8 2 0.250 0.004 MI:hsa-miR-141 mi 1 MI:hsa-miR-141 1 Q15436,P48729 103 4.78e-02 507 8 2 0.250 0.004 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 P48729,O95487 103 4.79e-02 508 8 2 0.250 0.004 MI:mmu-miR-669b mi 1 MI:mmu-miR-669b 1 P48729,O95487 103 4.90e-02 2260 8 5 0.625 0.002 GO:0012505 CC 1 endomembrane system 1 Q15436,Q01968,O94979,O95487,P55735 103 4.99e-02 519 8 2 0.250 0.004 MI:hsa-miR-520e mi 1 MI:hsa-miR-520e 1 Q01968,Q9Y446 103 5.00e-02 5672 8 8 1.000 0.001 TF:M04117_0 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 0 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 5.00e-02 9 8 1 0.125 0.111 CORUM:87 cor 1 Nup 107-160 subcomplex 1 P55735 103 5.00e-02 152 8 4 0.500 0.026 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 Q15436,O94979,O95487,P55735 103 5.00e-02 5672 8 8 1.000 0.001 TF:M04122_0 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 0 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 5.00e-02 5672 8 8 1.000 0.001 TF:M04137_0 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 0 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 5.00e-02 17 8 1 0.125 0.059 REAC:196299 rea 1 Beta-catenin phosphorylation cascade 1 P48729 103 5.00e-02 14 8 1 0.125 0.071 GO:0035859 CC 1 Seh1-associated complex 1 P55735 103 5.00e-02 5672 8 8 1.000 0.001 TF:M04135_0 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 0 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 103 5.00e-02 2 8 1 0.125 0.500 OMIM:300009 omi 1 Dent Disease 1 Q01968 103 5.00e-02 16 8 2 0.250 0.125 HP:0010920 hp 1 Zonular cataract 1 Q15436,Q01968 103 5.00e-02 5672 8 8 1.000 0.001 TF:M04126_0 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 0 1 Q15436,P48729,Q01968,O94979,O95487,P55735,Q6ZRV2,Q9Y446 104 2.36e-03 15 2 1 0.500 0.067 TF:M06301_0 tf 1 Factor: ZNF404; motif: NTGGAATGGAGA; match class: 0 1 Q9BW19 104 4.27e-03 330 2 2 1.000 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q15004,Q9BW19 104 8.27e-03 459 2 2 1.000 0.004 GO:0007017 BP 1 microtubule-based process 1 Q15004,Q9BW19 104 1.07e-02 68 2 1 0.500 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 Q9BW19 104 1.28e-02 1442 2 2 1.000 0.001 TF:M04470_0 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 0 1 Q15004,Q9BW19 104 1.30e-02 1453 2 2 1.000 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 Q15004,Q9BW19 104 1.35e-02 86 2 1 0.500 0.012 TF:M00123_1 tf 1 Factor: c-Myc:Max; motif: NANCACGTGNNW; match class: 1 1 Q15004 104 1.38e-02 88 2 1 0.500 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 Q9BW19 104 1.61e-02 103 2 1 0.500 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q9BW19 104 1.86e-02 119 2 1 0.500 0.008 TF:M04470_1 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 1 1 Q9BW19 104 1.87e-02 29 2 1 0.500 0.034 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 Q15004 104 1.96e-02 1784 2 2 1.000 0.001 TF:M07299_1 tf 1 Factor: c-Myb; motif: NNNNCMGTTNNN; match class: 1 1 Q15004,Q9BW19 104 2.26e-02 758 2 2 1.000 0.003 GO:0007010 BP 1 cytoskeleton organization 1 Q15004,Q9BW19 104 2.31e-02 36 2 1 0.500 0.028 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 Q15004 104 2.42e-02 155 2 1 0.500 0.006 TF:M06428_0 tf 1 Factor: ZNF227; motif: NKGTAAAAAASM; match class: 0 1 Q15004 104 2.46e-02 1995 2 2 1.000 0.001 TF:M00699_0 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 0 1 Q15004,Q9BW19 104 2.63e-02 41 2 1 0.500 0.024 REAC:983189 rea 1 Kinesins 1 Q9BW19 104 2.83e-02 44 2 1 0.500 0.023 REAC:73893 rea 1 DNA Damage Bypass 1 Q15004 104 2.96e-02 2189 2 2 1.000 0.001 TF:M01306_0 tf 1 Factor: ZABC1; motif: ATTCCNAC; match class: 0 1 Q15004,Q9BW19 104 3.15e-02 202 2 1 0.500 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 Q15004 104 3.15e-02 202 2 1 0.500 0.005 TF:M06128_0 tf 1 Factor: ZNF3; motif: NGGGCCAACCGM; match class: 0 1 Q9BW19 104 3.32e-02 213 2 1 0.500 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 Q9BW19 104 3.35e-02 37 2 1 0.500 0.027 GO:0019985 BP 1 translesion synthesis 1 Q15004 104 3.47e-02 223 2 1 0.500 0.004 TF:M06677_0 tf 1 Factor: ZNF285; motif: NGTTCMKAAAGM; match class: 0 1 Q9BW19 104 3.60e-02 231 2 1 0.500 0.004 TF:M05479_0 tf 1 Factor: znf580; motif: NGGGCGGTGTS; match class: 0 1 Q15004 104 3.71e-02 41 2 1 0.500 0.024 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q9BW19 104 3.82e-02 2487 2 2 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q15004,Q9BW19 104 3.82e-02 2487 2 2 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q15004,Q9BW19 104 3.82e-02 2487 2 2 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q15004,Q9BW19 104 3.84e-02 247 2 1 0.500 0.004 TF:M04004_1 tf 1 Factor: SOX9; motif: NAACAATRN; match class: 1 1 Q9BW19 104 3.86e-02 248 2 1 0.500 0.004 TF:M05317_0 tf 1 Factor: sox30; motif: YAAATTTTCN; match class: 0 1 Q15004 104 3.95e-02 254 2 1 0.500 0.004 TF:M01876_1 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 1 1 Q9BW19 104 4.15e-02 267 2 1 0.500 0.004 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 Q9BW19 104 4.15e-02 267 2 1 0.500 0.004 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 Q9BW19 104 4.24e-02 2620 2 2 1.000 0.001 TF:M04430_0 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 0 1 Q15004,Q9BW19 104 4.26e-02 2626 2 2 1.000 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q15004,Q9BW19 104 4.26e-02 274 2 1 0.500 0.004 TF:M04313_1 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 1 1 Q15004 104 4.35e-02 48 2 1 0.500 0.021 GO:0006301 BP 1 postreplication repair 1 Q15004 104 4.35e-02 48 2 1 0.500 0.021 GO:0051310 BP 1 metaphase plate congression 1 Q9BW19 104 4.41e-02 284 2 1 0.500 0.004 TF:M06515_0 tf 1 Factor: ZNF721; motif: GKAAAAAATC; match class: 0 1 Q9BW19 104 4.44e-02 49 2 1 0.500 0.020 GO:0005871 CC 1 kinesin complex 1 Q9BW19 104 4.44e-02 286 2 1 0.500 0.003 TF:M04414_1 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 1 1 Q15004 104 4.51e-02 290 2 1 0.500 0.003 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 Q9BW19 104 4.80e-02 53 2 1 0.500 0.019 GO:0090307 BP 1 mitotic spindle assembly 1 Q9BW19 104 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q15004,Q9BW19 104 4.89e-02 54 2 1 0.500 0.019 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 Q9BW19 104 4.92e-02 317 2 1 0.500 0.003 TF:M03982_1 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 1 Q9BW19 104 4.98e-02 55 2 1 0.500 0.018 GO:0051303 BP 1 establishment of chromosome localization 1 Q9BW19 104 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 Q15004 104 5.00e-02 78 2 1 0.500 0.013 REAC:6811434 rea 1 COPI-dependent Golgi-to-ER retrograde traffic 1 Q9BW19 104 5.00e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 Q15004,Q9BW19 104 5.00e-02 2 2 1 0.500 0.500 CORUM:1039 cor 1 PCNA-PAF complex 1 Q15004 104 5.00e-02 2 2 1 0.500 0.500 CORUM:1040 cor 1 p33ING1b-PCNA complex 1 Q15004 105 8.15e-12 31 7 5 0.714 0.161 GO:0030049 BP 1 muscle filament sliding 1 P35609,P09493,P19237,P13533,P07951 105 8.15e-12 31 7 5 0.714 0.161 GO:0033275 BP 1 actin-myosin filament sliding 1 P35609,P09493,P19237,P13533,P07951 105 2.84e-10 61 7 5 0.714 0.082 GO:0070252 BP 1 actin-mediated cell contraction 1 P35609,P09493,P19237,P13533,P07951 105 9.42e-10 77 7 5 0.714 0.065 GO:0030048 BP 1 actin filament-based movement 1 P35609,P09493,P19237,P13533,P07951 105 1.38e-09 83 7 5 0.714 0.060 GO:0030017 CC 1 sarcomere 1 P35609,P09493,P19237,P13533,P07951 105 1.91e-09 26 7 5 0.714 0.192 REAC:390522 rea 1 Striated Muscle Contraction 1 P35609,P09493,P19237,P13533,P07951 105 2.61e-09 94 7 5 0.714 0.053 GO:0030016 CC 1 myofibril 1 P35609,P09493,P19237,P13533,P07951 105 2.75e-09 95 7 5 0.714 0.053 GO:0044449 CC 1 contractile fiber part 1 P35609,P09493,P19237,P13533,P07951 105 3.76e-09 101 7 5 0.714 0.050 GO:0043292 CC 1 contractile fiber 1 P35609,P09493,P19237,P13533,P07951 105 4.38e-08 164 7 5 0.714 0.030 GO:0006936 BP 1 muscle contraction 1 P35609,P09493,P19237,P13533,P07951 105 9.18e-08 190 7 5 0.714 0.026 GO:0003012 BP 1 muscle system process 1 P35609,P09493,P19237,P13533,P07951 105 1.52e-07 13 7 3 0.429 0.231 GO:0045214 BP 1 sarcomere organization 1 P35609,P09493,P13533 105 2.42e-07 15 7 3 0.429 0.200 GO:0005865 CC 1 striated muscle thin filament 1 P09493,P19237,P07951 105 3.62e-07 17 7 3 0.429 0.176 GO:0036379 CC 1 myofilament 1 P09493,P19237,P07951 105 9.97e-07 306 7 5 0.714 0.016 GO:0015629 CC 1 actin cytoskeleton 1 P35609,P09493,P19237,P13533,P07951 105 1.55e-06 27 7 3 0.429 0.111 GO:0030239 BP 1 myofibril assembly 1 P35609,P09493,P13533 105 1.55e-06 27 7 3 0.429 0.111 GO:0008307 MF 1 structural constituent of muscle 1 P35609,P09493,P07951 105 4.76e-06 419 7 5 0.714 0.012 GO:0030029 BP 1 actin filament-based process 1 P35609,P09493,P19237,P13533,P07951 105 4.83e-06 39 7 3 0.429 0.077 GO:0043462 BP 1 regulation of ATPase activity 1 P09493,P13533,P07951 105 6.07e-06 42 7 3 0.429 0.071 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 P35609,P09493,P13533 105 7.01e-06 933 7 6 0.857 0.006 GO:0044430 CC 1 cytoskeletal part 1 Q9NXG0,P35609,P09493,P19237,P13533,P07951 105 7.38e-06 4 7 2 0.286 0.500 GO:0005862 CC 1 muscle thin filament tropomyosin 1 P09493,P07951 105 7.49e-06 45 7 3 0.429 0.067 GO:0055002 BP 1 striated muscle cell development 1 P35609,P09493,P13533 105 1.01e-05 18 7 3 0.429 0.167 OMIM:192600 omi 1 Hypertrophic Cardiomyopathy 1 P35609,P09493,P13533 105 1.10e-05 138 7 5 0.714 0.036 REAC:397014 rea 1 Muscle contraction 1 P35609,P09493,P19237,P13533,P07951 105 1.31e-05 54 7 3 0.429 0.056 GO:0055001 BP 1 muscle cell development 1 P35609,P09493,P13533 105 1.54e-05 57 7 3 0.429 0.053 GO:0060048 BP 1 cardiac muscle contraction 1 P09493,P19237,P13533 105 3.18e-05 1204 7 6 0.857 0.005 GO:0005856 CC 1 cytoskeleton 1 Q9NXG0,P35609,P09493,P19237,P13533,P07951 105 3.54e-05 75 7 3 0.429 0.040 GO:0006941 BP 1 striated muscle contraction 1 P09493,P19237,P13533 105 4.30e-05 80 7 3 0.429 0.037 GO:0051146 BP 1 striated muscle cell differentiation 1 P35609,P09493,P13533 105 5.71e-05 693 7 5 0.714 0.007 GO:0003008 BP 1 system process 1 P35609,P09493,P19237,P13533,P07951 105 6.55e-05 92 7 3 0.429 0.033 GO:0031032 BP 1 actomyosin structure organization 1 P35609,P09493,P13533 105 1.76e-04 128 7 3 0.429 0.023 GO:0060047 BP 1 heart contraction 1 P09493,P19237,P13533 105 1.85e-04 130 7 3 0.429 0.023 GO:0003015 BP 1 heart process 1 P09493,P19237,P13533 105 2.05e-04 414 7 4 0.571 0.010 GO:0005198 MF 1 structural molecule activity 1 P35609,P09493,Q8TDM6,P07951 105 2.26e-04 139 7 3 0.429 0.022 GO:0042692 BP 1 muscle cell differentiation 1 P35609,P09493,P13533 105 3.02e-04 61 7 3 0.429 0.049 KEGG:04260 keg 1 Cardiac muscle contraction 1 P09493,P13533,P07951 105 3.67e-04 25 7 2 0.286 0.080 GO:0055010 BP 1 ventricular cardiac muscle tissue morphogenesis 1 P09493,P13533 105 3.70e-04 1016 7 5 0.714 0.005 GO:0006928 BP 1 movement of cell or subcellular component 1 P35609,P09493,P19237,P13533,P07951 105 3.81e-04 485 7 4 0.571 0.008 GO:0008092 MF 1 cytoskeletal protein binding 1 P35609,P09493,Q8TDM6,P07951 105 3.83e-04 66 7 3 0.429 0.045 KEGG:05410 keg 1 Hypertrophic cardiomyopathy (HCM) 1 P09493,P13533,P07951 105 3.97e-04 26 7 2 0.286 0.077 GO:0003229 BP 1 ventricular cardiac muscle tissue development 1 P09493,P13533 105 4.24e-04 33 7 3 0.429 0.091 HP:0001706 hp 1 Endocardial fibroelastosis 1 P35609,P09493,P13533 105 4.24e-04 33 7 3 0.429 0.091 HP:0006673 hp 1 Reduced systolic function 1 P35609,P09493,P13533 105 4.24e-04 33 7 3 0.429 0.091 HP:0006670 hp 1 Impaired myocardial contractility 1 P35609,P09493,P13533 105 4.77e-04 71 7 3 0.429 0.042 KEGG:05414 keg 1 Dilated cardiomyopathy 1 P09493,P13533,P07951 105 5.31e-04 30 7 2 0.286 0.067 GO:0055008 BP 1 cardiac muscle tissue morphogenesis 1 P09493,P13533 105 5.53e-04 36 7 3 0.429 0.083 HP:0011713 hp 1 Left bundle branch block 1 P35609,P09493,P13533 105 5.53e-04 36 7 3 0.429 0.083 HP:0006685 hp 1 Endocardial fibrosis 1 P35609,P09493,P13533 105 5.58e-04 1960 7 6 0.857 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9NXG0,P35609,P09493,P19237,P13533,P07951 105 5.58e-04 1960 7 6 0.857 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9NXG0,P35609,P09493,P19237,P13533,P07951 105 6.44e-04 33 7 2 0.286 0.061 GO:0048644 BP 1 muscle organ morphogenesis 1 P09493,P13533 105 6.44e-04 33 7 2 0.286 0.061 GO:0060415 BP 1 muscle tissue morphogenesis 1 P09493,P13533 105 6.52e-04 38 7 3 0.429 0.079 HP:0004971 hp 1 Pulmonary artery hypoplasia 1 P35609,P09493,P13533 105 7.24e-04 114 7 4 0.571 0.035 HP:0001644 hp 1 Dilated cardiomyopathy 1 P35609,P09493,P13533,P07951 105 7.80e-04 211 7 3 0.429 0.014 GO:0008015 BP 1 blood circulation 1 P09493,P19237,P13533 105 7.91e-04 212 7 3 0.429 0.014 GO:0003013 BP 1 circulatory system process 1 P09493,P19237,P13533 105 8.12e-04 37 7 2 0.286 0.054 GO:0003208 BP 1 cardiac ventricle morphogenesis 1 P09493,P13533 105 8.14e-04 214 7 3 0.429 0.014 GO:0044057 BP 1 regulation of system process 1 P09493,P19237,P13533 105 8.48e-04 217 7 3 0.429 0.014 GO:0061061 BP 1 muscle structure development 1 P35609,P09493,P13533 105 8.84e-04 42 7 3 0.429 0.071 HP:0001723 hp 1 Restrictive cardiomyopathy 1 P35609,P09493,P13533 105 9.03e-04 39 7 2 0.286 0.051 GO:0002027 BP 1 regulation of heart rate 1 P09493,P13533 105 1.09e-03 45 7 3 0.429 0.067 HP:0011712 hp 1 Right bundle branch block 1 P35609,P09493,P13533 105 1.20e-03 45 7 2 0.286 0.044 GO:0003231 BP 1 cardiac ventricle development 1 P09493,P13533 105 1.32e-03 48 7 3 0.429 0.062 HP:0004749 hp 1 Atrial flutter 1 P35609,P09493,P13533 105 1.32e-03 48 7 3 0.429 0.062 HP:0100578 hp 1 Lipoatrophy 1 P35609,P09493,P13533 105 1.37e-03 48 7 2 0.286 0.042 GO:0003206 BP 1 cardiac chamber morphogenesis 1 P09493,P13533 105 1.41e-03 135 7 4 0.571 0.030 HP:0003457 hp 1 EMG abnormality 1 P35609,P09493,P13533,P07951 105 1.49e-03 50 7 3 0.429 0.060 HP:0011710 hp 1 Bundle branch block 1 P35609,P09493,P13533 105 1.68e-03 52 7 3 0.429 0.058 HP:0001279 hp 1 Syncope 1 P35609,P09493,P13533 105 1.80e-03 55 7 2 0.286 0.036 GO:0008217 BP 1 regulation of blood pressure 1 P09493,P13533 105 1.80e-03 55 7 2 0.286 0.036 GO:0003205 BP 1 cardiac chamber development 1 P09493,P13533 105 1.99e-03 55 7 3 0.429 0.055 HP:0009125 hp 1 Lipodystrophy 1 P35609,P09493,P13533 105 2.15e-03 758 7 4 0.571 0.005 GO:0007010 BP 1 cytoskeleton organization 1 Q9NXG0,P35609,P09493,P13533 105 2.33e-03 58 7 3 0.429 0.052 HP:0004756 hp 1 Ventricular tachycardia 1 P35609,P09493,P13533 105 2.35e-03 154 7 4 0.571 0.026 HP:0003198 hp 1 Myopathy 1 P35609,P09493,P13533,P07951 105 2.37e-03 1 7 1 0.143 1.000 GO:0070080 MF 1 titin Z domain binding 1 P35609 105 2.37e-03 1 7 1 0.143 1.000 GO:0003065 BP 1 positive regulation of heart rate by epinephrine 1 P09493 105 2.37e-03 1 7 1 0.143 1.000 GO:1904753 BP 1 negative regulation of vascular associated smooth muscle cell migration 1 P09493 105 2.37e-03 1 7 1 0.143 1.000 GO:0007522 BP 1 visceral muscle development 1 P13533 105 2.39e-03 122 7 3 0.429 0.025 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 P09493,P13533,P07951 105 2.45e-03 59 7 3 0.429 0.051 HP:0001699 hp 1 Sudden death 1 P35609,P09493,P13533 105 2.58e-03 60 7 3 0.429 0.050 HP:0004306 hp 1 Abnormality of the endocardium 1 P35609,P09493,P13533 105 2.58e-03 60 7 3 0.429 0.050 HP:0001678 hp 1 Atrioventricular block 1 P35609,P09493,P13533 105 2.74e-03 1 7 1 0.143 1.000 OMIM:614089 omi 1 ATRIAL SEPTAL DEFECT 3; ASD3 1 P13533 105 2.74e-03 1 7 1 0.143 1.000 OMIM:612158 omi 1 CARDIOMYOPATHY, DILATED, 1AA, WITH OR WITHOUT LEFT VENTRICULAR NONCOMPACTION;CMD1AACARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 23, WITH OR WITHOUT VENTRICULARNONCOMPACTION, INCLUDED; CMH23, INCLUDED 1 P35609 105 2.74e-03 1 7 1 0.143 1.000 OMIM:115196 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3; CMH3 1 P09493 105 2.74e-03 1 7 1 0.143 1.000 OMIM:613252 omi 1 CARDIOMYOPATHY, DILATED, 1EE; CMD1EE 1 P13533 105 2.74e-03 1 7 1 0.143 1.000 OMIM:614090 omi 1 SICK SINUS SYNDROME 3, SUSCEPTIBILITY TO; SSS3 1 P13533 105 2.74e-03 1 7 1 0.143 1.000 OMIM:611878 omi 1 CARDIOMYOPATHY, DILATED, 1Y; CMD1YLEFT VENTRICULAR NONCOMPACTION 9, INCLUDED; LVNC9, INCLUDED 1 P09493 105 2.74e-03 1 7 1 0.143 1.000 OMIM:609285 omi 1 NEMALINE MYOPATHY 4; NEM4CAP MYOPATHY 2, INCLUDED; CAPM2, INCLUDED 1 P07951 105 2.74e-03 1 7 1 0.143 1.000 OMIM:613251 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 14; CMH14 1 P13533 105 2.75e-03 68 7 2 0.286 0.029 GO:0006937 BP 1 regulation of muscle contraction 1 P09493,P19237 105 2.85e-03 62 7 3 0.429 0.048 HP:0001962 hp 1 Palpitations 1 P35609,P09493,P13533 105 3.00e-03 71 7 2 0.286 0.028 GO:0048738 BP 1 cardiac muscle tissue development 1 P09493,P13533 105 3.43e-03 66 7 3 0.429 0.045 HP:0005150 hp 1 Abnormal atrioventricular conduction 1 P35609,P09493,P13533 105 3.43e-03 66 7 3 0.429 0.045 HP:0012722 hp 1 Heart block 1 P35609,P09493,P13533 105 3.58e-03 67 7 3 0.429 0.045 HP:0011462 hp 1 Young adult onset 1 P35609,P09493,P13533 105 3.58e-03 67 7 3 0.429 0.045 HP:0001653 hp 1 Mitral regurgitation 1 P35609,P09493,P13533 105 3.58e-03 67 7 3 0.429 0.045 HP:0005180 hp 1 Tricuspid regurgitation 1 P35609,P09493,P13533 105 3.69e-03 358 7 3 0.429 0.008 GO:0030036 BP 1 actin cytoskeleton organization 1 P35609,P09493,P13533 105 4.29e-03 85 7 2 0.286 0.024 GO:0090257 BP 1 regulation of muscle system process 1 P09493,P19237 105 4.31e-03 180 7 4 0.571 0.022 HP:0003701 hp 1 Proximal muscle weakness 1 P35609,P09493,P13533,P07951 105 4.44e-03 72 7 3 0.429 0.042 HP:0005110 hp 1 Atrial fibrillation 1 P35609,P09493,P13533 105 4.45e-03 382 7 3 0.429 0.008 GO:0048646 BP 1 anatomical structure formation involved in morphogenesis 1 P35609,P09493,P13533 105 4.62e-03 73 7 3 0.429 0.041 HP:0004308 hp 1 Ventricular arrhythmia 1 P35609,P09493,P13533 105 4.73e-03 2 7 1 0.143 0.500 GO:0051695 BP 1 actin filament uncapping 1 P35609 105 4.73e-03 2 7 1 0.143 0.500 GO:0086097 BP 1 phospholipase C-activating angiotensin-activated signaling pathway 1 P35609 105 4.73e-03 2 7 1 0.143 0.500 GO:0032059 CC 1 bleb 1 P09493 105 4.73e-03 2 7 1 0.143 0.500 GO:0001996 BP 1 positive regulation of heart rate by epinephrine-norepinephrine 1 P09493 105 4.73e-03 2 7 1 0.143 0.500 GO:0051373 MF 1 FATZ binding 1 P35609 105 4.81e-03 90 7 2 0.286 0.022 GO:0003007 BP 1 heart morphogenesis 1 P09493,P13533 105 5.01e-03 75 7 3 0.429 0.040 HP:0001692 hp 1 Primary atrial arrhythmia 1 P35609,P09493,P13533 105 5.21e-03 76 7 3 0.429 0.039 HP:0004755 hp 1 Supraventricular tachycardia 1 P35609,P09493,P13533 105 5.41e-03 77 7 3 0.429 0.039 HP:0005115 hp 1 Supraventricular arrhythmia 1 P35609,P09493,P13533 105 6.75e-03 83 7 3 0.429 0.036 HP:0001702 hp 1 Abnormality of the tricuspid valve 1 P35609,P09493,P13533 105 6.93e-03 445 7 3 0.429 0.007 GO:0070925 BP 1 organelle assembly 1 P35609,P09493,P13533 105 7.03e-03 109 7 2 0.286 0.018 GO:0014706 BP 1 striated muscle tissue development 1 P09493,P13533 105 7.10e-03 3 7 1 0.143 0.333 GO:0055009 BP 1 atrial cardiac muscle tissue morphogenesis 1 P13533 105 7.10e-03 3 7 1 0.143 0.333 GO:1904706 BP 1 negative regulation of vascular smooth muscle cell proliferation 1 P09493 105 7.10e-03 3 7 1 0.143 0.333 GO:0003228 BP 1 atrial cardiac muscle tissue development 1 P13533 105 7.10e-03 3 7 1 0.143 0.333 GO:0030035 BP 1 microspike assembly 1 P35609 105 7.15e-03 110 7 2 0.286 0.018 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 P35609,P09493 105 7.39e-03 207 7 4 0.571 0.019 HP:0003621 hp 1 Juvenile onset 1 P35609,P09493,P13533,P07951 105 7.54e-03 113 7 2 0.286 0.018 GO:0060537 BP 1 muscle tissue development 1 P09493,P13533 105 7.95e-03 116 7 2 0.286 0.017 GO:0008016 BP 1 regulation of heart contraction 1 P09493,P13533 105 8.19e-03 3 7 1 0.143 0.333 OMIM:601680 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 2B; DA2B;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE 2B;;SHELDON-HALL SYNDROME; SHS;;FREEMAN-SHELDON SYNDROME VARIANT; FSSV;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE II, WITH CRANIOFACIALABNORMALITIES 1 P07951 105 8.56e-03 90 7 3 0.429 0.033 HP:0001297 hp 1 Stroke 1 P35609,P09493,P13533 105 8.84e-03 91 7 3 0.429 0.033 HP:0001712 hp 1 Left ventricular hypertrophy 1 P35609,P09493,P13533 105 9.06e-03 124 7 2 0.286 0.016 GO:0007517 BP 1 muscle organ development 1 P09493,P13533 105 9.46e-03 4 7 1 0.143 0.250 GO:2001137 BP 1 positive regulation of endocytic recycling 1 P35609 105 9.46e-03 4 7 1 0.143 0.250 GO:0001993 BP 1 regulation of systemic arterial blood pressure by norepinephrine-epinephrine 1 P09493 105 9.46e-03 4 7 1 0.143 0.250 GO:0017018 MF 1 myosin phosphatase activity 1 P13533 105 9.46e-03 4 7 1 0.143 0.250 GO:0003321 BP 1 positive regulation of blood pressure by epinephrine-norepinephrine 1 P09493 105 9.46e-03 4 7 1 0.143 0.250 GO:0007512 BP 1 adult heart development 1 P13533 105 1.00e-02 506 7 3 0.429 0.006 GO:0051336 BP 1 regulation of hydrolase activity 1 P09493,P13533,P07951 105 1.06e-02 515 7 3 0.429 0.006 GO:0032989 BP 1 cellular component morphogenesis 1 P35609,P09493,P13533 105 1.11e-02 1168 7 4 0.571 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q9NXG0,P35609,P09493,P13533 105 1.17e-02 141 7 2 0.286 0.014 GO:1903522 BP 1 regulation of blood circulation 1 P09493,P13533 105 1.18e-02 5 7 1 0.143 0.200 GO:0003062 BP 1 regulation of heart rate by chemical signal 1 P09493 105 1.18e-02 5 7 1 0.143 0.200 GO:1904738 BP 1 vascular associated smooth muscle cell migration 1 P09493 105 1.18e-02 5 7 1 0.143 0.200 GO:1904752 BP 1 regulation of vascular associated smooth muscle cell migration 1 P09493 105 1.18e-02 5 7 1 0.143 0.200 GO:0010460 BP 1 positive regulation of heart rate 1 P09493 105 1.18e-02 5 7 1 0.143 0.200 GO:0048739 BP 1 cardiac muscle fiber development 1 P13533 105 1.31e-02 104 7 3 0.429 0.029 HP:0001711 hp 1 Abnormality of the left ventricle 1 P35609,P09493,P13533 105 1.34e-02 105 7 3 0.429 0.029 HP:0001680 hp 1 Coarctation of aorta 1 P35609,P09493,P13533 105 1.42e-02 6 7 1 0.143 0.167 GO:2001135 BP 1 regulation of endocytic recycling 1 P35609 105 1.42e-02 6 7 1 0.143 0.167 GO:0005861 CC 1 troponin complex 1 P19237 105 1.42e-02 6 7 1 0.143 0.167 GO:2000009 BP 1 negative regulation of protein localization to cell surface 1 P35609 105 1.42e-02 107 7 3 0.429 0.028 HP:0000982 hp 1 Palmoplantar keratoderma 1 P35609,P09493,P13533 105 1.42e-02 107 7 3 0.429 0.028 HP:0001649 hp 1 Tachycardia 1 P35609,P09493,P13533 105 1.42e-02 107 7 3 0.429 0.028 HP:0001714 hp 1 Ventricular hypertrophy 1 P35609,P09493,P13533 105 1.54e-02 110 7 3 0.429 0.027 HP:0001645 hp 1 Sudden cardiac death 1 P35609,P09493,P13533 105 1.58e-02 111 7 3 0.429 0.027 HP:0009124 hp 1 Abnormality of adipose tissue 1 P35609,P09493,P13533 105 1.62e-02 112 7 3 0.429 0.027 HP:0001695 hp 1 Cardiac arrest 1 P35609,P09493,P13533 105 1.62e-02 112 7 3 0.429 0.027 HP:0001647 hp 1 Bicuspid aortic valve 1 P35609,P09493,P13533 105 1.65e-02 7 7 1 0.143 0.143 GO:0038166 BP 1 angiotensin-activated signaling pathway 1 P35609 105 1.65e-02 7 7 1 0.143 0.143 GO:0045777 BP 1 positive regulation of blood pressure 1 P09493 105 1.68e-02 170 7 2 0.286 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 P35609,P09493 105 1.76e-02 174 7 2 0.286 0.011 GO:0007507 BP 1 heart development 1 P09493,P13533 105 1.88e-02 118 7 3 0.429 0.025 HP:0004414 hp 1 Abnormality of the pulmonary artery 1 P35609,P09493,P13533 105 1.89e-02 8 7 1 0.143 0.125 GO:1904705 BP 1 regulation of vascular smooth muscle cell proliferation 1 P09493 105 1.89e-02 8 7 1 0.143 0.125 GO:1990776 BP 1 response to angiotensin 1 P35609 105 1.89e-02 8 7 1 0.143 0.125 GO:0045823 BP 1 positive regulation of heart contraction 1 P09493 105 1.89e-02 8 7 1 0.143 0.125 GO:1904385 BP 1 cellular response to angiotensin 1 P35609 105 1.89e-02 8 7 1 0.143 0.125 GO:1990874 BP 1 vascular smooth muscle cell proliferation 1 P09493 105 1.89e-02 8 7 1 0.143 0.125 GO:1901017 BP 1 negative regulation of potassium ion transmembrane transporter activity 1 P35609 105 1.90e-02 7 7 1 0.143 0.143 OMIM:108120 omi 1 Distal Arthrogryposes 1 P07951 105 2.11e-02 1388 7 4 0.571 0.003 GO:0065009 BP 1 regulation of molecular function 1 P35609,P09493,P13533,P07951 105 2.13e-02 9 7 1 0.143 0.111 GO:0031432 MF 1 titin binding 1 P35609 105 2.13e-02 9 7 1 0.143 0.111 GO:0030836 BP 1 positive regulation of actin filament depolymerization 1 P35609 105 2.13e-02 9 7 1 0.143 0.111 GO:0031143 CC 1 pseudopodium 1 P35609 105 2.13e-02 9 7 1 0.143 0.111 GO:0030898 MF 1 actin-dependent ATPase activity 1 P13533 105 2.16e-02 193 7 2 0.286 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 P35609,P09493 105 2.17e-02 8 7 1 0.143 0.125 OMIM:161800 omi 1 Nemaline Myopathy 1 P07951 105 2.20e-02 195 7 2 0.286 0.010 GO:0003779 MF 1 actin binding 1 P09493,P07951 105 2.31e-02 678 7 3 0.429 0.004 GO:0007155 BP 1 cell adhesion 1 P35609,P09493,Q8TDM6 105 2.36e-02 10 7 1 0.143 0.100 GO:0010457 BP 1 centriole-centriole cohesion 1 Q9NXG0 105 2.36e-02 10 7 1 0.143 0.100 GO:0014912 BP 1 negative regulation of smooth muscle cell migration 1 P09493 105 2.36e-02 10 7 1 0.143 0.100 GO:1901018 BP 1 positive regulation of potassium ion transmembrane transporter activity 1 P35609 105 2.36e-02 10 7 1 0.143 0.100 GO:1901380 BP 1 negative regulation of potassium ion transmembrane transport 1 P35609 105 2.37e-02 684 7 3 0.429 0.004 GO:0022610 BP 1 biological adhesion 1 P35609,P09493,Q8TDM6 105 2.44e-02 129 7 3 0.429 0.023 HP:0001633 hp 1 Abnormality of the mitral valve 1 P35609,P09493,P13533 105 2.44e-02 9 7 1 0.143 0.111 OMIM:604169 omi 1 Left Ventricular Noncompaction 1 P09493 105 2.59e-02 212 7 2 0.286 0.009 GO:0007015 BP 1 actin filament organization 1 P35609,P09493 105 2.75e-02 3782 7 7 1.000 0.002 TF:M07300_1 tf 1 Factor: NF-1C; motif: TTGGCNN; match class: 1 1 Q9NXG0,P35609,P09493,Q8TDM6,P19237,P13533,P07951 105 2.83e-02 12 7 1 0.143 0.083 GO:0048662 BP 1 negative regulation of smooth muscle cell proliferation 1 P09493 105 2.83e-02 12 7 1 0.143 0.083 GO:0003209 BP 1 cardiac atrium morphogenesis 1 P13533 105 2.83e-02 12 7 1 0.143 0.083 GO:1901881 BP 1 positive regulation of protein depolymerization 1 P35609 105 2.83e-02 12 7 1 0.143 0.083 GO:0043267 BP 1 negative regulation of potassium ion transport 1 P35609 105 2.83e-02 12 7 1 0.143 0.083 GO:0002026 BP 1 regulation of the force of heart contraction 1 P13533 105 3.07e-02 13 7 1 0.143 0.077 GO:1901381 BP 1 positive regulation of potassium ion transmembrane transport 1 P35609 105 3.30e-02 14 7 1 0.143 0.071 GO:0003230 BP 1 cardiac atrium development 1 P13533 105 3.43e-02 45 7 2 0.286 0.044 TF:M06555_0 tf 1 Factor: ZNF721; motif: NGGTGTGGGTGC; match class: 0 1 P09493,P13533 105 3.54e-02 15 7 1 0.143 0.067 GO:0005859 CC 1 muscle myosin complex 1 P13533 105 3.55e-02 790 7 3 0.429 0.004 GO:0048468 BP 1 cell development 1 P35609,P09493,P13533 105 3.75e-02 150 7 3 0.429 0.020 HP:0001874 hp 1 Abnormality of neutrophils 1 P35609,P09493,P13533 105 3.77e-02 2707 7 5 0.714 0.002 GO:0005829 CC 1 cytosol 1 P35609,P09493,P19237,P13533,P07951 105 3.77e-02 16 7 1 0.143 0.062 GO:0043243 BP 1 positive regulation of protein complex disassembly 1 P35609 105 3.77e-02 16 7 1 0.143 0.062 GO:2001259 BP 1 positive regulation of cation channel activity 1 P35609 105 3.77e-02 16 7 1 0.143 0.062 GO:0048747 BP 1 muscle fiber development 1 P13533 105 3.86e-02 2 7 1 0.143 0.500 HP:0005155 hp 1 Ventricular escape rhythms 1 P13533 105 3.99e-02 265 7 2 0.286 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 P35609,P09493 105 4.11e-02 269 7 2 0.286 0.007 GO:0048729 BP 1 tissue morphogenesis 1 P09493,P13533 105 4.12e-02 155 7 3 0.429 0.019 HP:0001635 hp 1 Congestive heart failure 1 P35609,P09493,P13533 105 4.24e-02 18 7 1 0.143 0.056 GO:0043268 BP 1 positive regulation of potassium ion transport 1 P35609 105 4.24e-02 18 7 1 0.143 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 P35609 105 4.24e-02 18 7 1 0.143 0.056 GO:0000146 MF 1 microfilament motor activity 1 P13533 105 4.24e-02 18 7 1 0.143 0.056 GO:0030159 MF 1 receptor signaling complex scaffold activity 1 Q8TDM6 105 4.24e-02 18 7 1 0.143 0.056 GO:0055013 BP 1 cardiac muscle cell development 1 P13533 105 4.33e-02 1028 7 4 0.571 0.004 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 P35609,P09493,P19237,P07951 105 4.35e-02 158 7 3 0.429 0.019 HP:0004930 hp 1 Abnormality of the pulmonary vasculature 1 P35609,P09493,P13533 105 4.43e-02 333 7 4 0.571 0.012 HP:0001638 hp 1 Cardiomyopathy 1 P35609,P09493,P13533,P07951 105 4.48e-02 19 7 1 0.143 0.053 GO:0003009 BP 1 skeletal muscle contraction 1 P19237 105 4.48e-02 19 7 1 0.143 0.053 GO:0014910 BP 1 regulation of smooth muscle cell migration 1 P09493 105 4.58e-02 421 7 3 0.429 0.007 MI:hsa-miR-409-3p mi 1 MI:hsa-miR-409-3p 1 Q9NXG0,P09493,P07951 105 4.71e-02 20 7 1 0.143 0.050 GO:0016460 CC 1 myosin II complex 1 P13533 105 4.71e-02 20 7 1 0.143 0.050 GO:0055006 BP 1 cardiac cell development 1 P13533 105 4.71e-02 289 7 2 0.286 0.007 GO:0008285 BP 1 negative regulation of cell proliferation 1 P09493,Q8TDM6 105 4.92e-02 165 7 3 0.429 0.018 HP:0001911 hp 1 Abnormality of granulocytes 1 P35609,P09493,P13533 105 4.94e-02 21 7 1 0.143 0.048 GO:0050879 BP 1 multicellular organismal movement 1 P19237 105 4.94e-02 21 7 1 0.143 0.048 GO:0050881 BP 1 musculoskeletal movement 1 P19237 105 5.00e-02 476 7 3 0.429 0.006 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P35609,P09493,P13533 105 5.00e-02 2546 7 6 0.857 0.002 TF:M00941_0 tf 1 Factor: MEF-2; motif: RGCTATWTTTAR; match class: 0 1 Q9NXG0,P35609,P09493,P19237,P13533,P07951 105 5.00e-02 298 7 2 0.286 0.007 GO:0019904 MF 1 protein domain specific binding 1 Q9NXG0,P35609 105 5.00e-02 434 7 3 0.429 0.007 MI:mmu-miR-463 mi 1 MI:mmu-miR-463 1 P09493,P19237,P07951 105 5.00e-02 166 7 3 0.429 0.018 HP:0006705 hp 1 Abnormality of the atrioventricular valves 1 P35609,P09493,P13533 105 5.00e-02 111 7 2 0.286 0.018 KEGG:04530 keg 1 Tight junction 1 P35609,P13533 105 5.00e-02 24 7 2 0.286 0.083 REAC:445355 rea 1 Smooth Muscle Contraction 1 P09493,P07951 106 2.16e-05 671 6 5 0.833 0.007 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 2.16e-05 671 6 5 0.833 0.007 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.62e-05 298 6 4 0.667 0.013 GO:0000976 MF 1 transcription regulatory region sequence-specific DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 5.04e-05 324 6 4 0.667 0.012 GO:1990837 MF 1 sequence-specific double-stranded DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 9.89e-05 384 6 4 0.667 0.010 GO:0003690 MF 1 double-stranded DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 1.58e-04 432 6 4 0.667 0.009 GO:0000975 MF 1 regulatory region DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 1.58e-04 432 6 4 0.667 0.009 GO:0044212 MF 1 transcription regulatory region DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 1.58e-04 432 6 4 0.667 0.009 GO:0001067 MF 1 regulatory region nucleic acid binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 2.26e-04 473 6 4 0.667 0.008 GO:0043565 MF 1 sequence-specific DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 3.47e-04 1177 6 5 0.833 0.004 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.07e-03 922 6 4 0.667 0.004 GO:0003677 MF 1 DNA binding 1 Q9Y4A8,Q14494,Q9BYV9,Q16236 106 3.29e-03 1865 6 5 0.833 0.003 GO:0006351 BP 1 transcription, DNA-templated 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.35e-03 1872 6 5 0.833 0.003 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.74e-03 970 6 4 0.667 0.004 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 4.39e-03 1980 6 5 0.833 0.003 GO:0032774 BP 1 RNA biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 6.08e-03 4613 6 6 1.000 0.001 HPA:026010 hpa 1 ovary; follicle cells 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 8.07e-03 1460 6 4 0.667 0.003 TF:M00528_0 tf 1 Factor: PPAR; motif: WASNRGGNCAAAGGTCA; match class: 0 1 Q9Y4A8,Q9BYV9,Q16236,Q6ICC9 106 8.35e-03 1473 6 4 0.667 0.003 TF:M04076_0 tf 1 Factor: POU3F1; motif: WTATGCWAATNN; match class: 0 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 8.44e-03 2267 6 5 0.833 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 8.97e-03 3 6 1 0.167 0.333 GO:0010499 BP 1 proteasomal ubiquitin-independent protein catabolic process 1 Q16236 106 8.97e-03 3 6 1 0.167 0.333 GO:0007567 BP 1 parturition 1 Q9ULX9 106 9.14e-03 2305 6 5 0.833 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 9.23e-03 2310 6 5 0.833 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 9.95e-03 1543 6 4 0.667 0.003 TF:M04074_0 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 0 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 1.05e-02 2374 6 5 0.833 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 1.46e-02 209 6 2 0.333 0.010 TF:M04201_0 tf 1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 0 1 Q16236,Q6ICC9 106 1.68e-02 3156 6 5 0.833 0.002 TF:M07041_1 tf 1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 1 Q9Y4A8,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 1.68e-02 3157 6 5 0.833 0.002 TF:M00051_0 tf 1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 0 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 1.69e-02 1775 6 4 0.667 0.002 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 Q9Y4A8,Q14494,Q9BYV9,Q6ICC9 106 1.71e-02 2627 6 5 0.833 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 1.79e-02 6 6 1 0.167 0.167 GO:0071499 BP 1 cellular response to laminar fluid shear stress 1 Q16236 106 1.92e-02 422 6 2 0.333 0.005 MI:hsa-miR-885-5p mi 1 MI:hsa-miR-885-5p 1 Q14494,Q9BYV9 106 1.97e-02 2707 6 5 0.833 0.002 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 2.03e-02 3704 6 5 0.833 0.001 HPA:026010_01 hpa 1 ovary; follicle cells[Uncertain,Low] 1 Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 2.09e-02 7 6 1 0.167 0.143 GO:0034616 BP 1 response to laminar fluid shear stress 1 Q16236 106 2.09e-02 7 6 1 0.167 0.143 GO:1903071 BP 1 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 1 Q16236 106 2.13e-02 12 6 1 0.167 0.083 TF:M05875_0 tf 1 Factor: ZNF526; motif: NGGTTGGCGTTT; match class: 0 1 Q14494 106 2.18e-02 257 6 2 0.333 0.008 TF:M04203_1 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 1 1 Q16236,Q6ICC9 106 2.20e-02 2770 6 5 0.833 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 2.23e-02 895 6 3 0.500 0.003 TF:M00338_0 tf 1 Factor: ATF; motif: NTGACGTCANYS; match class: 0 1 Q9BYV9,Q9ULX9,Q6ICC9 106 2.46e-02 1962 6 4 0.667 0.002 TF:M01595_0 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 0 1 Q9Y4A8,Q9BYV9,Q16236,Q9ULX9 106 2.49e-02 14 6 1 0.167 0.071 TF:M05475_0 tf 1 Factor: ZBTB41; motif: NTGGGGGGTAGA; match class: 0 1 Q9ULX9 106 2.60e-02 2869 6 5 0.833 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 2.62e-02 741 6 3 0.500 0.004 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 Q9Y4A8,Q14494,Q16236 106 2.62e-02 741 6 3 0.500 0.004 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 Q9Y4A8,Q14494,Q16236 106 2.69e-02 9 6 1 0.167 0.111 GO:1903069 BP 1 regulation of ER-associated ubiquitin-dependent protein catabolic process 1 Q16236 106 2.84e-02 762 6 3 0.500 0.004 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 Q9Y4A8,Q14494,Q16236 106 2.87e-02 1656 6 4 0.667 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 2.91e-02 1663 6 4 0.667 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 2.92e-02 985 6 3 0.500 0.003 TF:M03907_0 tf 1 Factor: HINFP; motif: CNRCGTCCGCNN; match class: 0 1 Q14494,Q16236,Q9ULX9 106 2.99e-02 10 6 1 0.167 0.100 GO:1901032 BP 1 negative regulation of response to reactive oxygen species 1 Q16236 106 2.99e-02 10 6 1 0.167 0.100 GO:1903206 BP 1 negative regulation of hydrogen peroxide-induced cell death 1 Q16236 106 2.99e-02 10 6 1 0.167 0.100 GO:0071498 BP 1 cellular response to fluid shear stress 1 Q16236 106 3.03e-02 1681 6 4 0.667 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 3.06e-02 3583 6 5 0.833 0.001 TF:M05444_1 tf 1 Factor: CPBP; motif: NGGGCGG; match class: 1 1 Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.06e-02 3583 6 5 0.833 0.001 TF:M05361_1 tf 1 Factor: Sp6; motif: WGGGCGG; match class: 1 1 Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.06e-02 3583 6 5 0.833 0.001 TF:M05332_1 tf 1 Factor: Sp2; motif: WGGGCGG; match class: 1 1 Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.16e-02 791 6 3 0.500 0.004 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 Q9Y4A8,Q14494,Q16236 106 3.28e-02 3013 6 5 0.833 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.42e-02 3668 6 5 0.833 0.001 TF:M00698_0 tf 1 Factor: HEB; motif: RCCWGCTG; match class: 0 1 Q9Y4A8,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.45e-02 5821 6 6 1.000 0.001 TF:M05548_0 tf 1 Factor: PLAGL2; motif: AAGGACC; match class: 0 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.50e-02 328 6 2 0.333 0.006 TF:M00179_1 tf 1 Factor: ATF2; motif: VGTGACGTMACN; match class: 1 1 Q9BYV9,Q9ULX9 106 3.51e-02 3058 6 5 0.833 0.002 GO:0010467 BP 1 gene expression 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9 106 3.57e-02 1058 6 3 0.500 0.003 TF:M04083_0 tf 1 Factor: POU3F4; motif: TATGCWAAT; match class: 0 1 Q14494,Q16236,Q9ULX9 106 3.58e-02 12 6 1 0.167 0.083 GO:0036499 BP 1 PERK-mediated unfolded protein response 1 Q16236 106 3.58e-02 12 6 1 0.167 0.083 GO:1904294 BP 1 positive regulation of ERAD pathway 1 Q16236 106 3.61e-02 5864 6 6 1.000 0.001 TF:M02070_1 tf 1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.68e-02 2189 6 4 0.667 0.002 TF:M00322_0 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 0 1 Q9Y4A8,Q16236,Q9ULX9,Q6ICC9 106 3.71e-02 1775 6 4 0.667 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 3.73e-02 6241 6 6 1.000 0.001 HPA:029020_02 hpa 1 placenta; trophoblastic cells[Uncertain,Medium] 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 3.88e-02 13 6 1 0.167 0.077 GO:1903205 BP 1 regulation of hydrogen peroxide-induced cell death 1 Q16236 106 3.97e-02 350 6 2 0.333 0.006 TF:M00721_0 tf 1 Factor: CACCC-binding; motif: CANCCNNWGGGTGDGG; match class: 0 1 Q9Y4A8,Q9ULX9 106 3.97e-02 1099 6 3 0.500 0.003 TF:M04070_0 tf 1 Factor: POU2F1; motif: NWTATGCWAATN; match class: 0 1 Q14494,Q16236,Q9ULX9 106 4.18e-02 14 6 1 0.167 0.071 GO:0006783 BP 1 heme biosynthetic process 1 Q14494 106 4.25e-02 24 6 1 0.167 0.042 TF:M04204_1 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 1 1 Q16236 106 4.41e-02 2299 6 4 0.667 0.002 TF:M07246_0 tf 1 Factor: ATF-4; motif: NNTKRCRTCANS; match class: 0 1 Q9Y4A8,Q9BYV9,Q16236,Q9ULX9 106 4.43e-02 25 6 1 0.167 0.040 TF:M07229_1 tf 1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 1 Q14494 106 4.43e-02 25 6 1 0.167 0.040 TF:M06261_0 tf 1 Factor: ZNF271; motif: NGGTGCAACARA; match class: 0 1 Q9Y4A8 106 4.47e-02 15 6 1 0.167 0.067 GO:0036474 BP 1 cell death in response to hydrogen peroxide 1 Q16236 106 4.47e-02 15 6 1 0.167 0.067 GO:1902176 BP 1 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 Q16236 106 4.47e-02 15 6 1 0.167 0.067 GO:0034405 BP 1 response to fluid shear stress 1 Q16236 106 4.47e-02 15 6 1 0.167 0.067 GO:2000352 BP 1 negative regulation of endothelial cell apoptotic process 1 Q16236 106 4.50e-02 896 6 3 0.500 0.003 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q9Y4A8,Q14494,Q16236 106 4.55e-02 3900 6 5 0.833 0.001 TF:M07226_0 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 0 1 Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 4.59e-02 6105 6 6 1.000 0.001 TF:M07129_0 tf 1 Factor: Sp2; motif: GYCCCGCCYCYNNNN; match class: 0 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q9ULX9,Q6ICC9 106 4.64e-02 652 6 2 0.333 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q14494,Q16236 106 4.70e-02 382 6 2 0.333 0.005 TF:M07246_1 tf 1 Factor: ATF-4; motif: NNTKRCRTCANS; match class: 1 1 Q9BYV9,Q9ULX9 106 4.70e-02 382 6 2 0.333 0.005 TF:M04150_0 tf 1 Factor: TFAP2B; motif: NGCCTSAGGCN; match class: 0 1 Q9Y4A8,Q14494 106 4.77e-02 16 6 1 0.167 0.062 GO:0006779 BP 1 porphyrin-containing compound biosynthetic process 1 Q14494 106 4.86e-02 3956 6 5 0.833 0.001 TF:M00004_0 tf 1 Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 0 1 Q9Y4A8,Q14494,Q9BYV9,Q16236,Q6ICC9 106 4.87e-02 922 6 3 0.500 0.003 GO:0010628 BP 1 positive regulation of gene expression 1 Q9Y4A8,Q14494,Q16236 106 4.89e-02 390 6 2 0.333 0.005 TF:M01820_1 tf 1 Factor: CREM; motif: TGACGTCASYN; match class: 1 1 Q9BYV9,Q9ULX9 106 4.96e-02 28 6 1 0.167 0.036 TF:M06695_0 tf 1 Factor: ZNF160; motif: CTAAATCCGC; match class: 0 1 Q9Y4A8 106 5.00e-02 3 6 1 0.167 0.333 CORUM:5805 cor 1 PGAM5-KEAP1-NRF2 complex 1 Q16236 106 5.00e-02 1923 6 4 0.667 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q9Y4A8,Q14494,Q16236,Q9ULX9 106 5.00e-02 2379 6 4 0.667 0.002 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q9Y4A8,Q9BYV9,Q9ULX9,Q6ICC9 107 2.72e-03 1147 4 3 0.750 0.003 TF:M06837_0 tf 1 Factor: ZNF367; motif: TGCTRTNMYMC; match class: 0 1 Q9NVN8,Q15345,Q9Y295 107 4.08e-03 13 4 1 0.250 0.077 TF:M03976_0 tf 1 Factor: ERG; motif: ACCGGAWATCCGGT; match class: 0 1 Q15345 107 4.55e-03 1 4 1 0.250 1.000 GO:0018194 BP 1 peptidyl-alanine modification 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0035573 BP 1 N-terminal peptidyl-serine trimethylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0018016 BP 1 N-terminal peptidyl-proline dimethylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0035572 BP 1 N-terminal peptidyl-serine dimethylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0035570 BP 1 N-terminal peptidyl-serine methylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0018011 BP 1 N-terminal peptidyl-alanine methylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0018013 BP 1 N-terminal peptidyl-glycine methylation 1 Q9BV86 107 4.55e-03 1 4 1 0.250 1.000 GO:0035568 BP 1 N-terminal peptidyl-proline methylation 1 Q9BV86 107 4.63e-03 3321 4 4 1.000 0.001 TF:M00084_1 tf 1 Factor: MZF-1; motif: KNGNKAGGGGNAA; match class: 1 1 Q9NVN8,Q15345,Q9BV86,Q9Y295 107 4.69e-03 363 4 2 0.500 0.006 TF:M01122_0 tf 1 Factor: ZNF219; motif: CRCCCCCCNCCC; match class: 0 1 Q9NVN8,Q9BV86 107 4.97e-03 374 4 2 0.500 0.005 TF:M03902_0 tf 1 Factor: GLI2; motif: GCGACCACMCTR; match class: 0 1 Q9NVN8,Q15345 107 9.08e-03 509 4 2 0.500 0.004 TF:M00491_1 tf 1 Factor: MAZR; motif: NSGGGGGGGGMCN; match class: 1 1 Q9NVN8,Q9BV86 107 9.10e-03 2 4 1 0.250 0.500 GO:0071885 MF 1 N-terminal protein N-methyltransferase activity 1 Q9BV86 107 9.10e-03 2 4 1 0.250 0.500 GO:0006480 BP 1 N-terminal protein amino acid methylation 1 Q9BV86 107 1.09e-02 559 4 2 0.500 0.004 TF:M02063_1 tf 1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 1 Q9NVN8,Q15345 107 1.13e-02 3521 4 4 1.000 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q9NVN8,Q15345,Q9BV86,Q9Y295 107 1.31e-02 42 4 1 0.250 0.024 TF:M06218_0 tf 1 Factor: ZNF169; motif: NRGTYCAGRATA; match class: 0 1 Q15345 107 1.37e-02 3 4 1 0.250 0.333 GO:0018201 BP 1 peptidyl-glycine modification 1 Q9BV86 107 1.37e-02 629 4 2 0.500 0.003 TF:M03983_1 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 1 1 Q9NVN8,Q15345 107 1.41e-02 45 4 1 0.250 0.022 TF:M05672_0 tf 1 Factor: ZNF133; motif: NARTGAAAAAGA; match class: 0 1 Q9NVN8 107 1.54e-02 290 4 2 0.500 0.007 MI:hsa-miR-23b* mi 1 MI:hsa-miR-23b* 1 Q15345,Q9BV86 107 1.83e-02 731 4 2 0.500 0.003 TF:M02068_1 tf 1 Factor: etv3; motif: ACCGGAAGYN; match class: 1 1 Q9NVN8,Q15345 107 1.83e-02 2215 4 3 0.750 0.001 TF:M07341_1 tf 1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 1 Q9NVN8,Q15345,Q9BV86 107 1.90e-02 323 4 2 0.500 0.006 MI:hsa-miR-143* mi 1 MI:hsa-miR-143* 1 Q9NVN8,Q9BV86 107 1.95e-02 53 4 1 0.250 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q9NVN8 107 2.01e-02 332 4 2 0.500 0.006 MI:hsa-miR-23a* mi 1 MI:hsa-miR-23a* 1 Q15345,Q9Y295 107 2.04e-02 773 4 2 0.500 0.003 TF:M00294_1 tf 1 Factor: HFH8; motif: NNNTGTTTATNTR; match class: 1 1 Q9NVN8,Q9Y295 107 2.04e-02 335 4 2 0.500 0.006 MI:hsa-miR-636 mi 1 MI:hsa-miR-636 1 Q9NVN8,Q9Y295 107 2.10e-02 340 4 2 0.500 0.006 MI:hsa-miR-148b* mi 1 MI:hsa-miR-148b* 1 Q9BV86,Q9Y295 107 2.22e-02 809 4 2 0.500 0.002 TF:M02058_0 tf 1 Factor: SAP1A; motif: NCCGGAARYN; match class: 0 1 Q9NVN8,Q15345 107 2.22e-02 809 4 2 0.500 0.002 TF:M03990_0 tf 1 Factor: GABPA; motif: ACCGGAAGTN; match class: 0 1 Q9NVN8,Q15345 107 2.43e-02 366 4 2 0.500 0.005 MI:hsa-miR-138-2* mi 1 MI:hsa-miR-138-2* 1 Q9NVN8,Q9Y295 107 2.58e-02 83 4 1 0.250 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 Q9BV86 107 2.73e-02 6 4 1 0.250 0.167 GO:0033234 BP 1 negative regulation of protein sumoylation 1 Q9NVN8 107 2.73e-02 6 4 1 0.250 0.167 GO:0090073 BP 1 positive regulation of protein homodimerization activity 1 Q9NVN8 107 2.77e-02 391 4 2 0.500 0.005 MI:mmu-miR-678 mi 1 MI:mmu-miR-678 1 Q15345,Q9BV86 107 2.77e-02 89 4 1 0.250 0.011 TF:M06132_0 tf 1 Factor: ZNF823; motif: NYYACCAGCCCT; match class: 0 1 Q9BV86 107 2.95e-02 404 4 2 0.500 0.005 MI:hsa-miR-126 mi 1 MI:hsa-miR-126 1 Q9NVN8,Q15345 107 3.11e-02 415 4 2 0.500 0.005 MI:hsa-miR-491-5p mi 1 MI:hsa-miR-491-5p 1 Q9NVN8,Q9Y295 107 3.15e-02 5365 4 4 1.000 0.001 TF:M00349_0 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 0 1 Q9NVN8,Q15345,Q9BV86,Q9Y295 107 3.17e-02 102 4 1 0.250 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 Q15345 107 3.21e-02 422 4 2 0.500 0.005 MI:hsa-miR-512-3p mi 1 MI:hsa-miR-512-3p 1 Q9NVN8,Q9BV86 107 3.32e-02 429 4 2 0.500 0.005 MI:hsa-miR-30e* mi 1 MI:hsa-miR-30e* 1 Q9NVN8,Q9Y295 107 3.35e-02 108 4 1 0.250 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q9Y295 107 3.39e-02 434 4 2 0.500 0.005 MI:rno-miR-336 mi 1 MI:rno-miR-336 1 Q9BV86,Q9Y295 107 3.51e-02 1029 4 2 0.500 0.002 TF:M02059_0 tf 1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 0 1 Q9NVN8,Q15345 107 3.57e-02 115 4 1 0.250 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 Q9NVN8 107 3.59e-02 447 4 2 0.500 0.004 MI:hsa-miR-18b mi 1 MI:hsa-miR-18b 1 Q9NVN8,Q9Y295 107 3.63e-02 117 4 1 0.250 0.009 TF:M06285_0 tf 1 Factor: ZNF124; motif: NGGTACTTGGGA; match class: 0 1 Q9NVN8 107 3.72e-02 1061 4 2 0.500 0.002 TF:M00052_0 tf 1 Factor: NF-kappaB; motif: GGGRATTTCC; match class: 0 1 Q15345,Q9Y295 107 3.72e-02 1062 4 2 0.500 0.002 TF:M07209_0 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 0 1 Q9NVN8,Q15345 107 3.74e-02 1065 4 2 0.500 0.002 TF:M01971_0 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 0 1 Q15345,Q9Y295 107 3.77e-02 458 4 2 0.500 0.004 MI:hsa-miR-509-5p mi 1 MI:hsa-miR-509-5p 1 Q9NVN8,Q9BV86 107 3.77e-02 5608 4 4 1.000 0.001 TF:M07368_0 tf 1 Factor: Smad4; motif: NCAGACAN; match class: 0 1 Q9NVN8,Q15345,Q9BV86,Q9Y295 107 3.86e-02 464 4 2 0.500 0.004 MI:hsa-miR-30a* mi 1 MI:hsa-miR-30a* 1 Q9NVN8,Q9Y295 107 3.89e-02 1087 4 2 0.500 0.002 TF:M00208_0 tf 1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 0 1 Q15345,Q9Y295 107 3.96e-02 470 4 2 0.500 0.004 MI:hsa-miR-18a mi 1 MI:hsa-miR-18a 1 Q9NVN8,Q9Y295 107 4.08e-02 477 4 2 0.500 0.004 MI:hsa-miR-106a mi 1 MI:hsa-miR-106a 1 Q9NVN8,Q9BV86 107 4.15e-02 1125 4 2 0.500 0.002 TF:M00054_0 tf 1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 0 1 Q15345,Q9Y295 107 4.20e-02 2973 4 3 0.750 0.001 TF:M00427_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 Q9NVN8,Q15345,Q9BV86 107 4.41e-02 121 4 1 0.250 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 Q9NVN8 107 4.43e-02 498 4 2 0.500 0.004 MI:hsa-miR-125a-3p mi 1 MI:hsa-miR-125a-3p 1 Q9NVN8,Q9Y295 107 4.45e-02 499 4 2 0.500 0.004 MI:hsa-miR-20a mi 1 MI:hsa-miR-20a 1 Q9NVN8,Q9BV86 107 4.46e-02 1169 4 2 0.500 0.002 TF:M03972_0 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 0 1 Q9NVN8,Q15345 107 4.59e-02 507 4 2 0.500 0.004 MI:mmu-miR-322 mi 1 MI:mmu-miR-322 1 Q9BV86,Q9Y295 107 4.62e-02 1191 4 2 0.500 0.002 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q9NVN8,Q9Y295 107 4.63e-02 150 4 1 0.250 0.007 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 Q15345 107 4.69e-02 513 4 2 0.500 0.004 MI:hsa-miR-20b mi 1 MI:hsa-miR-20b 1 Q9NVN8,Q9BV86 107 4.69e-02 513 4 2 0.500 0.004 MI:hsa-miR-106b mi 1 MI:hsa-miR-106b 1 Q9NVN8,Q9BV86 107 4.71e-02 514 4 2 0.500 0.004 MI:hsa-miR-93 mi 1 MI:hsa-miR-93 1 Q9NVN8,Q9BV86 107 4.73e-02 515 4 2 0.500 0.004 MI:hsa-miR-424 mi 1 MI:hsa-miR-424 1 Q9BV86,Q9Y295 107 4.81e-02 3121 4 3 0.750 0.001 TF:M00701_1 tf 1 Factor: SMAD3; motif: TGTCTGTCT; match class: 1 1 Q9NVN8,Q15345,Q9BV86 107 4.89e-02 524 4 2 0.500 0.004 MI:hsa-miR-15b mi 1 MI:hsa-miR-15b 1 Q9BV86,Q9Y295 107 4.90e-02 3143 4 3 0.750 0.001 TF:M01744_0 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 0 1 Q9NVN8,Q15345,Q9Y295 107 4.92e-02 1232 4 2 0.500 0.002 TF:M00473_1 tf 1 Factor: FOXO1; motif: NRWAAACAAN; match class: 1 1 Q9NVN8,Q9Y295 107 4.95e-02 136 4 1 0.250 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q9NVN8 107 5.00e-02 530 4 2 0.500 0.004 MI:hsa-miR-130a mi 1 MI:hsa-miR-130a 1 Q9NVN8,Q15345 107 5.00e-02 11 4 1 0.250 0.091 GO:0032211 BP 1 negative regulation of telomere maintenance via telomerase 1 Q9NVN8 107 5.00e-02 11 4 1 0.250 0.091 GO:1904816 BP 1 positive regulation of protein localization to chromosome, telomeric region 1 Q9NVN8 107 5.00e-02 11 4 1 0.250 0.091 GO:0018208 BP 1 peptidyl-proline modification 1 Q9BV86 108 4.18e-03 424 3 2 0.667 0.005 MI:mmu-miR-715 mi 1 MI:mmu-miR-715 1 Q9H1B7,Q9NR12 108 5.06e-03 467 3 2 0.667 0.004 MI:hsa-miR-891a mi 1 MI:hsa-miR-891a 1 Q9H1B7,Q9NR12 108 5.32e-03 479 3 2 0.667 0.004 MI:hsa-let-7e mi 1 MI:hsa-let-7e 1 Q9H1B7,Q9NR12 108 1.73e-02 2791 3 3 1.000 0.001 HPA:007020_02 hpa 1 cerebral cortex; glial cells[Uncertain,Medium] 1 Q9H1B7,Q7Z5L9,Q9NR12 108 1.83e-02 867 3 2 0.667 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q9H1B7,Q7Z5L9 108 2.16e-02 945 3 2 0.667 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 Q9H1B7,Q7Z5L9 108 3.07e-02 1138 3 3 1.000 0.003 TF:M01593_1 tf 1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 1 1 Q9H1B7,Q7Z5L9,Q9NR12 108 3.29e-02 1175 3 2 0.667 0.002 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q9H1B7,Q7Z5L9 108 4.06e-02 4 3 1 0.333 0.250 TF:M04053_1 tf 1 Factor: NF-AT2; motif: TTTTCCATGGAAAN; match class: 1 1 Q9H1B7 108 4.86e-02 1440 3 2 0.667 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9H1B7,Q7Z5L9 108 5.00e-02 1 3 1 0.333 1.000 GO:0045136 BP 1 development of secondary sexual characteristics 1 Q9H1B7 108 5.00e-02 1 3 1 0.333 1.000 GO:0046543 BP 1 development of secondary female sexual characteristics 1 Q9H1B7 108 5.00e-02 1339 3 3 1.000 0.002 TF:M00634_0 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 0 1 Q9H1B7,Q7Z5L9,Q9NR12 109 2.25e-03 250 4 2 0.500 0.008 TF:M00464_0 tf 1 Factor: POU3F2; motif: TTATGYTAAT; match class: 0 1 Q9UQ84,P52738 109 2.46e-03 262 4 2 0.500 0.008 TF:M06887_1 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 1 1 Q9BRX9,P52738 109 2.83e-03 9 4 1 0.250 0.111 TF:M06512_0 tf 1 Factor: GIOT-1; motif: NGGTTGTAAAAA; match class: 0 1 P52738 109 4.08e-03 13 4 1 0.250 0.077 TF:M07306_1 tf 1 Factor: RORalpha; motif: NNWNNAWNTRGGTCAG; match class: 1 1 Q9BRX9 109 4.13e-03 1322 4 3 0.750 0.002 TF:M00113_0 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 0 1 Q9BRX9,Q9UQ84,P52738 109 5.14e-03 335 4 2 0.500 0.006 MI:hsa-miR-376a* mi 1 MI:hsa-miR-376a* 1 Q9UQ84,P52738 109 6.35e-03 424 4 2 0.500 0.005 TF:M03837_1 tf 1 Factor: Oct3; motif: TKWNATGCAWATN; match class: 1 1 Q9UQ84,P52738 109 7.28e-03 400 4 2 0.500 0.005 MI:hsa-miR-10b* mi 1 MI:hsa-miR-10b* 1 Q9UQ84,P52738 109 7.46e-03 405 4 2 0.500 0.005 MI:hsa-miR-618 mi 1 MI:hsa-miR-618 1 Q9UQ84,P52738 109 7.73e-03 14 4 1 0.250 0.071 REAC:5358606 rea 1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1 Q9UQ84 109 7.73e-03 14 4 1 0.250 0.071 REAC:5358565 rea 1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1 Q9UQ84 109 7.83e-03 25 4 1 0.250 0.040 TF:M07229_1 tf 1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 1 P52738 109 8.28e-03 15 4 1 0.250 0.067 REAC:5358508 rea 1 Mismatch Repair 1 Q9UQ84 109 8.34e-03 1 4 1 0.250 1.000 GO:0051908 MF 1 double-stranded DNA 5'-3' exodeoxyribonuclease activity 1 Q9UQ84 109 9.71e-03 31 4 1 0.250 0.032 TF:M05734_0 tf 1 Factor: ZNF697; motif: NKGKGCGAGGGM; match class: 0 1 Q9BRX9 109 1.04e-02 4067 4 4 1.000 0.001 TF:M00346_1 tf 1 Factor: GATA-1; motif: NCWGATAACA; match class: 1 1 Q9H426,Q9BRX9,Q9UQ84,P52738 109 1.07e-02 487 4 2 0.500 0.004 MI:hsa-miR-323-3p mi 1 MI:hsa-miR-323-3p 1 Q9UQ84,P52738 109 1.12e-02 499 4 2 0.500 0.004 MI:hsa-miR-582-5p mi 1 MI:hsa-miR-582-5p 1 Q9UQ84,P52738 109 1.15e-02 505 4 2 0.500 0.004 MI:hsa-miR-519d mi 1 MI:hsa-miR-519d 1 Q9UQ84,P52738 109 1.16e-02 37 4 1 0.250 0.027 TF:M04309_1 tf 1 Factor: DUXA; motif: NTRAYYTAATCAN; match class: 1 1 Q9H426 109 1.19e-02 4206 4 4 1.000 0.001 TF:M01243_1 tf 1 Factor: MTF-1; motif: TGCGCAC; match class: 1 1 Q9H426,Q9BRX9,Q9UQ84,P52738 109 1.23e-02 595 4 2 0.500 0.003 TF:M00483_1 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 1 1 Q9BRX9,P52738 109 1.34e-02 43 4 1 0.250 0.023 TF:M05648_0 tf 1 Factor: ZNF883; motif: KGTGGCTGCCTC; match class: 0 1 Q9H426 109 1.43e-02 26 4 1 0.250 0.038 REAC:5693554 rea 1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 Q9UQ84 109 1.44e-02 646 4 2 0.500 0.003 TF:M00342_1 tf 1 Factor: Oct-1; motif: TATGCAAATN; match class: 1 1 Q9UQ84,P52738 109 1.53e-02 49 4 1 0.250 0.020 TF:M06325_0 tf 1 Factor: ZNF585A; motif: ATGTNTAAAAWC; match class: 0 1 Q9UQ84 109 1.56e-02 50 4 1 0.250 0.020 TF:M06529_0 tf 1 Factor: ZNF596; motif: NGGTCGGGAAAA; match class: 0 1 Q9H426 109 1.60e-02 29 4 1 0.250 0.034 REAC:5693568 rea 1 Resolution of D-loop Structures through Holliday Junction Intermediates 1 Q9UQ84 109 1.65e-02 30 4 1 0.250 0.033 REAC:5693537 rea 1 Resolution of D-Loop Structures 1 Q9UQ84 109 1.67e-02 2 4 1 0.250 0.500 GO:0045145 MF 1 single-stranded DNA 5'-3' exodeoxyribonuclease activity 1 Q9UQ84 109 1.78e-02 635 4 2 0.500 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 Q9UQ84,P52738 109 1.87e-02 60 4 1 0.250 0.017 TF:M07311_1 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 1 1 P52738 109 1.92e-02 2251 4 3 0.750 0.001 TF:M06887_0 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 0 1 Q9H426,Q9BRX9,P52738 109 1.97e-02 759 4 2 0.500 0.003 TF:M03836_1 tf 1 Factor: oct-2; motif: NNWNATGCAAATNN; match class: 1 1 Q9UQ84,P52738 109 1.98e-02 36 4 1 0.250 0.028 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 Q9UQ84 109 2.03e-02 37 4 1 0.250 0.027 REAC:5674135 rea 1 MAP2K and MAPK activation 1 Q9BRX9 109 2.09e-02 38 4 1 0.250 0.026 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 Q9UQ84 109 2.21e-02 2367 4 3 0.750 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q9BRX9,Q9UQ84,P52738 109 2.25e-02 41 4 1 0.250 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 Q9UQ84 109 2.27e-02 73 4 1 0.250 0.014 TF:M06136_0 tf 1 Factor: ZNF647; motif: NTGTTAAGAAGC; match class: 0 1 P52738 109 2.72e-02 900 4 2 0.500 0.002 TF:M03565_1 tf 1 Factor: slug; motif: KCACCTGN; match class: 1 1 Q9H426,Q9BRX9 109 2.76e-02 906 4 2 0.500 0.002 TF:M00195_1 tf 1 Factor: Oct-1; motif: NNNNATGCAAATNAN; match class: 1 1 Q9UQ84,P52738 109 2.80e-02 90 4 1 0.250 0.011 TF:M06038_0 tf 1 Factor: TCF17; motif: NGKGGAAWAAKM; match class: 0 1 P52738 109 2.89e-02 93 4 1 0.250 0.011 TF:M06674_0 tf 1 Factor: znf587; motif: NGGGRCTGATGA; match class: 0 1 Q9UQ84 109 2.96e-02 940 4 2 0.500 0.002 TF:M06475_0 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 0 1 Q9UQ84,P52738 109 2.98e-02 96 4 1 0.250 0.010 TF:M05649_0 tf 1 Factor: ZFY; motif: KGGGGCTGCAGC; match class: 0 1 Q9UQ84 109 2.98e-02 96 4 1 0.250 0.010 TF:M05652_0 tf 1 Factor: ZFX; motif: KGGGGCTGCASC; match class: 0 1 Q9UQ84 109 3.01e-02 97 4 1 0.250 0.010 TF:M07420_1 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 1 1 Q9UQ84 109 3.11e-02 100 4 1 0.250 0.010 TF:M03967_0 tf 1 Factor: ELF3; motif: WACCCGGAAGTAN; match class: 0 1 Q9BRX9 109 3.11e-02 100 4 1 0.250 0.010 TF:M06551_0 tf 1 Factor: znf417; motif: NGGGRCTGATGA; match class: 0 1 Q9UQ84 109 3.17e-02 102 4 1 0.250 0.010 TF:M07089_1 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 1 1 Q9BRX9 109 3.20e-02 103 4 1 0.250 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 Q9UQ84 109 3.26e-02 105 4 1 0.250 0.010 TF:M07415_0 tf 1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 0 1 Q9BRX9 109 3.33e-02 4 4 1 0.250 0.250 GO:0008309 MF 1 double-stranded DNA exodeoxyribonuclease activity 1 Q9UQ84 109 3.33e-02 61 4 1 0.250 0.016 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q9UQ84 109 3.54e-02 2797 4 3 0.750 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q9BRX9,Q9UQ84,P52738 109 3.61e-02 5547 4 4 1.000 0.001 TF:M04152_1 tf 1 Factor: TFAP2C; motif: NGCCCNNRGGCA; match class: 1 1 Q9H426,Q9BRX9,Q9UQ84,P52738 109 3.78e-02 1070 4 2 0.500 0.002 TF:M07058_1 tf 1 Factor: POU2F1; motif: ATTTGCATN; match class: 1 1 Q9UQ84,P52738 109 3.90e-02 126 4 1 0.250 0.008 TF:M03968_0 tf 1 Factor: ELF4; motif: AACCCGGAAGTR; match class: 0 1 Q9BRX9 109 3.93e-02 72 4 1 0.250 0.014 REAC:69473 rea 1 G2/M DNA damage checkpoint 1 Q9UQ84 109 3.96e-02 128 4 1 0.250 0.008 TF:M06358_0 tf 1 Factor: ZNF787; motif: NTGRTAAGGCYM; match class: 0 1 Q9BRX9 109 3.97e-02 1099 4 2 0.500 0.002 TF:M07339_0 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 0 1 Q9BRX9,P52738 109 4.02e-02 628 4 2 0.500 0.003 REAC:212436 rea 1 Generic Transcription Pathway 1 Q9UQ84,P52738 109 4.02e-02 130 4 1 0.250 0.008 TF:M07210_1 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 1 1 P52738 109 4.03e-02 74 4 1 0.250 0.014 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 Q9UQ84 109 4.04e-02 1109 4 2 0.500 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 Q9UQ84,P52738 109 4.13e-02 2954 4 3 0.750 0.001 TF:M01861_0 tf 1 Factor: ATF-1; motif: TNACGTCAN; match class: 0 1 Q9BRX9,Q9UQ84,P52738 109 4.17e-02 5 4 1 0.250 0.200 GO:0008297 MF 1 single-stranded DNA exodeoxyribonuclease activity 1 Q9UQ84 109 4.21e-02 136 4 1 0.250 0.007 TF:M00157_1 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 1 1 Q9BRX9 109 4.23e-02 1136 4 2 0.500 0.002 TF:M05970_0 tf 1 Factor: Zipro1; motif: NTGAAGGAGGM; match class: 0 1 Q9H426,P52738 109 4.30e-02 139 4 1 0.250 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 Q9H426 109 4.32e-02 3003 4 3 0.750 0.001 TF:M00432_1 tf 1 Factor: TTF1; motif: ASTCAAGTRK; match class: 1 1 Q9BRX9,Q9UQ84,P52738 109 4.41e-02 3025 4 3 0.750 0.001 TF:M05609_0 tf 1 Factor: SALL3; motif: NMTTTTGRAYN; match class: 0 1 Q9H426,Q9BRX9,Q9UQ84 109 4.48e-02 145 4 1 0.250 0.007 TF:M01723_0 tf 1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 0 1 Q9H426 109 4.48e-02 145 4 1 0.250 0.007 TF:M02377_1 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 1 1 P52738 109 4.63e-02 150 4 1 0.250 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 P52738 109 4.68e-02 86 4 1 0.250 0.012 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q9UQ84 109 4.72e-02 153 4 1 0.250 0.007 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 Q9UQ84 109 4.94e-02 1235 4 2 0.500 0.002 TF:M07210_0 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 0 1 Q9BRX9,P52738 109 4.97e-02 3157 4 3 0.750 0.001 TF:M00051_0 tf 1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 0 1 Q9H426,Q9BRX9,P52738 109 5.00e-02 6 4 1 0.250 0.167 GO:0004523 MF 1 RNA-DNA hybrid ribonuclease activity 1 Q9UQ84 109 5.00e-02 3 4 1 0.250 0.333 CORUM:423 cor 1 EXO1-MLH1-PMS2 complex 1 Q9UQ84 109 5.00e-02 3 4 1 0.250 0.333 CORUM:424 cor 1 EXO1-MLH1-PCNA complex 1 Q9UQ84 109 5.00e-02 3 4 1 0.250 0.333 CORUM:415 cor 1 EXO1-MLH1-PMS2 complex 1 Q9UQ84 109 5.00e-02 6 4 1 0.250 0.167 GO:0048256 MF 1 flap endonuclease activity 1 Q9UQ84 109 5.00e-02 6 4 1 0.250 0.167 GO:0035312 MF 1 5'-3' exodeoxyribonuclease activity 1 Q9UQ84 109 5.00e-02 23 4 1 0.250 0.043 KEGG:03430 keg 1 Mismatch repair 1 Q9UQ84 110 3.11e-03 76 3 2 0.667 0.026 KEGG:05146 keg 1 Amoebiasis 1 Q05397,P48595 110 3.25e-03 373 3 2 0.667 0.005 MI:mmu-miR-741 mi 1 MI:mmu-miR-741 1 P54687,P48595 110 9.13e-03 2 3 1 0.333 0.500 CORUM:5712 cor 1 FAK-beta5 integrin complex, VEGF induced 1 Q05397 110 1.11e-02 4 3 1 0.333 0.250 KEGG:00290 keg 1 Valine, leucine and isoleucine biosynthesis 1 P54687 110 1.37e-02 3 3 1 0.333 0.333 CORUM:5282 cor 1 CAS-SRC-FAK complex 1 Q05397 110 1.37e-02 3 3 1 0.333 0.333 CORUM:2726 cor 1 PXN-ITGB5-PTK2 complex 1 Q05397 110 1.82e-02 4 3 1 0.333 0.250 CORUM:2896 cor 1 ITGA2b-ITGB3-CD47-FAK complex 1 Q05397 110 4.49e-02 8 3 1 0.333 0.125 TF:M07298_1 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 1 P48595 110 4.50e-02 9 3 1 0.333 0.111 REAC:418886 rea 1 Netrin mediated repulsion signals 1 Q05397 110 4.72e-02 17 3 1 0.333 0.059 KEGG:01210 keg 1 2-Oxocarboxylic acid metabolism 1 P54687 110 4.74e-02 1601 3 3 1.000 0.002 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 P54687,Q05397,P48595 110 5.00e-02 2 3 1 0.333 0.500 GO:0038007 BP 1 netrin-activated signaling pathway 1 Q05397 110 5.00e-02 2 3 1 0.333 0.500 GO:0004084 MF 1 branched-chain-amino-acid transaminase activity 1 P54687 110 5.00e-02 2 3 1 0.333 0.500 GO:0009098 BP 1 leucine biosynthetic process 1 P54687 110 5.00e-02 10 3 1 0.333 0.100 REAC:391160 rea 1 Signal regulatory protein (SIRP) family interactions 1 Q05397 110 5.00e-02 340 3 2 0.667 0.006 TF:M01856_1 tf 1 Factor: AML3; motif: AACCACAN; match class: 1 1 Q05397,P48595 110 5.00e-02 2 3 1 0.333 0.500 GO:0009082 BP 1 branched-chain amino acid biosynthetic process 1 P54687 110 5.00e-02 340 3 2 0.667 0.006 TF:M01759_1 tf 1 Factor: AML2; motif: AACCRCAA; match class: 1 1 Q05397,P48595 110 5.00e-02 2 3 1 0.333 0.500 GO:0009099 BP 1 valine biosynthetic process 1 P54687 110 5.00e-02 18 3 1 0.333 0.056 KEGG:00770 keg 1 Pantothenate and CoA biosynthesis 1 P54687 110 5.00e-02 11 3 1 0.333 0.091 CORUM:5177 cor 1 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 1 Q05397 111 6.54e-07 36 4 3 0.750 0.083 REAC:5663213 rea 1 RHO GTPases Activate WASPs and WAVEs 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.69e-06 68 4 3 0.750 0.044 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.69e-06 68 4 3 0.750 0.044 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.69e-06 68 4 3 0.750 0.044 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.94e-06 70 4 3 0.750 0.043 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.97e-06 59 4 3 0.750 0.051 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.07e-06 71 4 3 0.750 0.042 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 7.78e-06 81 4 3 0.750 0.037 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 8.71e-06 8 4 2 0.500 0.250 GO:0031209 CC 1 SCAR complex 1 Q8IZP0,Q9Y6W5 111 2.50e-05 142 4 3 0.750 0.021 GO:0006909 BP 1 phagocytosis 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.26e-05 2 4 2 0.500 1.000 CORUM:2294 cor 1 ABI1-WASF2 complex 1 Q8IZP0,Q9Y6W5 111 3.93e-05 165 4 3 0.750 0.018 GO:0038093 BP 1 Fc receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 8.34e-05 212 4 3 0.750 0.014 GO:0007015 BP 1 actin filament organization 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 8.82e-05 216 4 3 0.750 0.014 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.14e-04 235 4 3 0.750 0.013 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.74e-04 271 4 3 0.750 0.011 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.82e-04 275 4 3 0.750 0.011 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.82e-04 231 4 3 0.750 0.013 REAC:195258 rea 1 RHO GTPase Effectors 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.86e-04 277 4 3 0.750 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.96e-04 282 4 3 0.750 0.011 GO:0045296 MF 1 cadherin binding 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.22e-04 294 4 3 0.750 0.010 GO:0005913 CC 1 cell-cell adherens junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.43e-04 303 4 3 0.750 0.010 GO:0002757 BP 1 immune response-activating signal transduction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.78e-04 317 4 3 0.750 0.009 GO:0002252 BP 1 immune effector process 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.91e-04 322 4 3 0.750 0.009 GO:0002764 BP 1 immune response-regulating signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.96e-04 272 4 3 0.750 0.011 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.16e-04 278 4 3 0.750 0.011 REAC:194138 rea 1 Signaling by VEGF 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.26e-04 5 4 2 0.500 0.400 CORUM:186 cor 1 Wave-2 complex 1 Q8IZP0,Q9Y6W5 111 3.34e-04 337 4 3 0.750 0.009 GO:0002253 BP 1 activation of immune response 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.87e-04 354 4 3 0.750 0.008 GO:0006897 BP 1 endocytosis 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 4.00e-04 358 4 3 0.750 0.008 GO:0030036 BP 1 actin cytoskeleton organization 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 4.38e-04 369 4 3 0.750 0.008 GO:0050839 MF 1 cell adhesion molecule binding 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 5.05e-04 387 4 3 0.750 0.008 GO:0050778 BP 1 positive regulation of immune response 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 5.66e-04 338 4 3 0.750 0.009 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 6.39e-04 419 4 3 0.750 0.007 GO:0030029 BP 1 actin filament-based process 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 6.44e-04 420 4 3 0.750 0.007 GO:0005911 CC 1 cell-cell junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 7.00e-04 432 4 3 0.750 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 9.88e-04 485 4 3 0.750 0.006 GO:0008092 MF 1 cytoskeletal protein binding 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.05e-03 83 4 2 0.500 0.024 GO:0051017 BP 1 actin filament bundle assembly 1 Q9Y6W5,Q9UQB8 111 1.07e-03 84 4 2 0.500 0.024 GO:0061572 BP 1 actin filament bundle organization 1 Q9Y6W5,Q9UQB8 111 1.08e-03 499 4 3 0.750 0.006 GO:0002684 BP 1 positive regulation of immune system process 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.09e-03 501 4 3 0.750 0.006 GO:0050776 BP 1 regulation of immune response 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.23e-03 90 4 2 0.500 0.022 GO:0030027 CC 1 lamellipodium 1 Q8IZP0,Q9Y6W5 111 1.43e-03 199 4 2 0.500 0.010 TF:M06027_0 tf 1 Factor: ZNF891; motif: NNMACAAGGCAA; match class: 0 1 Q9Y6W5,Q9P206 111 1.70e-03 582 4 3 0.750 0.005 GO:0005912 CC 1 adherens junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.78e-03 591 4 3 0.750 0.005 GO:0070161 CC 1 anchoring junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.80e-03 593 4 3 0.750 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.08e-03 117 4 2 0.500 0.017 GO:0008154 BP 1 actin polymerization or depolymerization 1 Q8IZP0,Q9UQB8 111 2.81e-03 690 4 3 0.750 0.004 GO:0002682 BP 1 regulation of immune system process 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.44e-03 739 4 3 0.750 0.004 GO:0006955 BP 1 immune response 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.54e-03 746 4 3 0.750 0.004 GO:0030054 CC 1 cell junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.71e-03 758 4 3 0.750 0.004 GO:0007010 BP 1 cytoskeleton organization 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 4.39e-03 170 4 2 0.500 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 Q9Y6W5,Q9UQB8 111 4.70e-03 176 4 2 0.500 0.011 GO:0031252 CC 1 cell leading edge 1 Q8IZP0,Q9Y6W5 111 5.64e-03 193 4 2 0.500 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 Q9Y6W5,Q9UQB8 111 6.24e-03 420 4 2 0.500 0.005 TF:M05752_0 tf 1 Factor: ZNF57; motif: NCGGGGTGGKSA; match class: 0 1 Q8IZP0,Q9UQB8 111 7.00e-03 3682 4 4 1.000 0.001 TF:M00531_0 tf 1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 7.40e-03 958 4 3 0.750 0.003 GO:0016192 BP 1 vesicle-mediated transport 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 8.16e-03 70 4 2 0.500 0.029 KEGG:04520 keg 1 Adherens junction 1 Q9Y6W5,Q9UQB8 111 8.30e-03 1682 4 3 0.750 0.002 TF:M01778_1 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 9.08e-03 29 4 1 0.250 0.034 TF:M01123_1 tf 1 Factor: Nanog; motif: GGGNCCATTKCC; match class: 1 1 Q9P206 111 9.99e-03 4025 4 4 1.000 0.001 TF:M03814_1 tf 1 Factor: BTEB2; motif: GNAGGGGGNGGGSSNN; match class: 1 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 1.05e-02 264 4 2 0.500 0.008 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 Q9Y6W5,Q9UQB8 111 1.06e-02 550 4 2 0.500 0.004 TF:M00490_0 tf 1 Factor: Bach2; motif: SRTGAGTCANC; match class: 0 1 Q9Y6W5,Q9P206 111 1.06e-02 265 4 2 0.500 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q9Y6W5,Q9UQB8 111 1.07e-02 1086 4 3 0.750 0.003 GO:0048584 BP 1 positive regulation of response to stimulus 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.08e-02 9 4 1 0.250 0.111 GO:0051764 BP 1 actin crosslink formation 1 Q9UQB8 111 1.08e-02 9 4 1 0.250 0.111 GO:0010592 BP 1 positive regulation of lamellipodium assembly 1 Q9Y6W5 111 1.09e-02 1849 4 3 0.750 0.002 TF:M00193_1 tf 1 Factor: NF-1; motif: NNTTGGCNNNNNNCCNNN; match class: 1 1 Q9Y6W5,Q9P206,Q9UQB8 111 1.10e-02 1857 4 3 0.750 0.002 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 1.14e-02 938 4 3 0.750 0.003 REAC:168249 rea 1 Innate Immune System 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.17e-02 1897 4 3 0.750 0.002 TF:M00249_0 tf 1 Factor: CHOP:C/EBPalpha; motif: NNRTGCAATMCCC; match class: 0 1 Q8IZP0,Q9P206,Q9UQB8 111 1.18e-02 3559 4 4 1.000 0.001 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 1.20e-02 10 4 1 0.250 0.100 GO:0051497 BP 1 negative regulation of stress fiber assembly 1 Q9Y6W5 111 1.21e-02 590 4 2 0.500 0.003 TF:M07087_0 tf 1 Factor: Elf-1; motif: NRANCMGGAAGTG; match class: 0 1 Q8IZP0,Q9P206 111 1.31e-02 1165 4 3 0.750 0.003 GO:0002376 BP 1 immune system process 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.32e-02 1168 4 3 0.750 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.35e-02 1989 4 3 0.750 0.002 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 1.40e-02 306 4 2 0.500 0.007 GO:0015629 CC 1 actin cytoskeleton 1 Q9Y6W5,Q9UQB8 111 1.40e-02 2018 4 3 0.750 0.001 TF:M00658_1 tf 1 Factor: PU.1; motif: WGAGGAAG; match class: 1 1 Q8IZP0,Q9Y6W5,Q9P206 111 1.41e-02 45 4 1 0.250 0.022 TF:M06639_0 tf 1 Factor: znf559; motif: NGKGCCGACCGC; match class: 0 1 Q9P206 111 1.43e-02 12 4 1 0.250 0.083 GO:0070064 MF 1 proline-rich region binding 1 Q9UQB8 111 1.43e-02 12 4 1 0.250 0.083 GO:0032232 BP 1 negative regulation of actin filament bundle assembly 1 Q9Y6W5 111 1.47e-02 47 4 1 0.250 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 Q9UQB8 111 1.49e-02 2061 4 3 0.750 0.001 TF:M00777_0 tf 1 Factor: STAT; motif: NNNNNTTCTKGGA; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206 111 1.55e-02 4492 4 4 1.000 0.001 TF:M00339_0 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 1.55e-02 13 4 1 0.250 0.077 GO:2000251 BP 1 positive regulation of actin cytoskeleton reorganization 1 Q9UQB8 111 1.61e-02 685 4 2 0.500 0.003 TF:M00665_0 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 0 1 Q9P206,Q9UQB8 111 1.63e-02 1804 4 3 0.750 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 1.67e-02 2144 4 3 0.750 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 1.67e-02 14 4 1 0.250 0.071 GO:0008093 MF 1 cytoskeletal adaptor activity 1 Q9UQB8 111 1.70e-02 3899 4 4 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 1.72e-02 55 4 1 0.250 0.018 TF:M06393_0 tf 1 Factor: ZNF765; motif: NTGGYAAGGRSA; match class: 0 1 Q8IZP0 111 1.75e-02 56 4 1 0.250 0.018 TF:M05881_0 tf 1 Factor: ZNF676; motif: NGATTTGGGTGA; match class: 0 1 Q9P206 111 1.83e-02 731 4 2 0.500 0.003 TF:M07353_1 tf 1 Factor: E2A; motif: CAGNTGNN; match class: 1 1 Q9P206,Q9UQB8 111 1.89e-02 744 4 2 0.500 0.003 TF:M04417_0 tf 1 Factor: NOTO; motif: NYTAATTANN; match class: 0 1 Q8IZP0,Q9P206 111 1.89e-02 4006 4 4 1.000 0.001 HPA:029010_02 hpa 1 placenta; decidual cells[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 1.93e-02 62 4 1 0.250 0.016 TF:M05714_0 tf 1 Factor: Evi-1; motif: KGGTCMMAACTN; match class: 0 1 Q8IZP0 111 1.95e-02 2264 4 3 0.750 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q8IZP0,Q9Y6W5,Q9P206 111 2.03e-02 771 4 2 0.500 0.003 TF:M01219_1 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 1 Q9P206,Q9UQB8 111 2.03e-02 17 4 1 0.250 0.059 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 Q9Y6W5 111 2.03e-02 17 4 1 0.250 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 Q9Y6W5 111 2.19e-02 384 4 2 0.500 0.005 GO:0032403 MF 1 protein complex binding 1 Q8IZP0,Q9Y6W5 111 2.22e-02 808 4 2 0.500 0.002 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 Q9P206,Q9UQB8 111 2.24e-02 72 4 1 0.250 0.014 TF:M04183_0 tf 1 Factor: NEUROG2; motif: RACATATGTC; match class: 0 1 Q8IZP0 111 2.27e-02 73 4 1 0.250 0.014 TF:M06136_0 tf 1 Factor: ZNF647; motif: NTGTTAAGAAGC; match class: 0 1 Q9P206 111 2.31e-02 1416 4 3 0.750 0.002 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.34e-02 4978 4 4 1.000 0.001 TF:M02023_0 tf 1 Factor: MAZ; motif: NKGGGAGGGGRGGR; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.37e-02 4237 4 4 1.000 0.001 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.50e-02 4293 4 4 1.000 0.001 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.51e-02 4298 4 4 1.000 0.001 HPA:009010_02 hpa 1 colon; endothelial cells[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.52e-02 733 4 2 0.500 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q9Y6W5,Q9UQB8 111 2.57e-02 2497 4 3 0.750 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q8IZP0,Q9P206,Q9UQB8 111 2.64e-02 2521 4 3 0.750 0.001 TF:M05883_0 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 0 1 Q9Y6W5,Q9P206,Q9UQB8 111 2.72e-02 900 4 2 0.500 0.002 TF:M04440_1 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 1 1 Q8IZP0,Q9P206 111 2.72e-02 1498 4 3 0.750 0.002 GO:0044765 BP 1 single-organism transport 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 2.74e-02 88 4 1 0.250 0.011 TF:M05988_0 tf 1 Factor: ZNF860; motif: NTGGGAAAWGSM; match class: 0 1 Q9P206 111 2.78e-02 4407 4 4 1.000 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.78e-02 2177 4 3 0.750 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q8IZP0,Q9P206,Q9UQB8 111 2.86e-02 5233 4 4 1.000 0.001 TF:M07379_0 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 2.86e-02 24 4 1 0.250 0.042 GO:2000249 BP 1 regulation of actin cytoskeleton reorganization 1 Q9UQB8 111 2.95e-02 95 4 1 0.250 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 Q8IZP0 111 2.95e-02 95 4 1 0.250 0.011 TF:M04356_0 tf 1 Factor: HOXC12; motif: RGTCGTAAAAN; match class: 0 1 Q9Y6W5 111 3.20e-02 103 4 1 0.250 0.010 TF:M00264_1 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 1 1 Q8IZP0 111 3.22e-02 27 4 1 0.250 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q9Y6W5 111 3.22e-02 4574 4 4 1.000 0.001 HPA:021010_01 hpa 1 liver; bile duct cells[Uncertain,Low] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 3.32e-02 999 4 2 0.500 0.002 TF:M04594_0 tf 1 Factor: Zic3; motif: CCCGCTGGG; match class: 0 1 Q9Y6W5,Q9P206 111 3.32e-02 107 4 1 0.250 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q9UQB8 111 3.38e-02 109 4 1 0.250 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q9UQB8 111 3.50e-02 113 4 1 0.250 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q9UQB8 111 3.61e-02 1652 4 3 0.750 0.002 GO:1902578 BP 1 single-organism localization 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 3.70e-02 31 4 1 0.250 0.032 GO:0030032 BP 1 lamellipodium assembly 1 Q9Y6W5 111 3.70e-02 2840 4 3 0.750 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 3.72e-02 120 4 1 0.250 0.008 TF:M06463_0 tf 1 Factor: ZNF595; motif: NGKGGCGGCMGM; match class: 0 1 Q9P206 111 3.72e-02 504 4 2 0.500 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9Y6W5,Q9UQB8 111 3.88e-02 2888 4 3 0.750 0.001 TF:M01172_1 tf 1 Factor: PU.1; motif: NNNNYYYACTTCCTCTTTY; match class: 1 1 Q8IZP0,Q9Y6W5,Q9P206 111 3.90e-02 2454 4 3 0.750 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q9Y6W5,Q9P206,Q9UQB8 111 3.98e-02 2917 4 3 0.750 0.001 TF:M02078_1 tf 1 Factor: SPI1; motif: NGRGGAAGTN; match class: 1 1 Q8IZP0,Q9Y6W5,Q9P206 111 3.99e-02 1102 4 2 0.500 0.002 TF:M00471_1 tf 1 Factor: TBP; motif: TATAAATW; match class: 1 1 Q8IZP0,Q9Y6W5 111 4.02e-02 1457 4 3 0.750 0.002 REAC:168256 rea 1 Immune System 1 Q8IZP0,Q9Y6W5,Q9UQB8 111 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q9Y6W5,Q9UQB8 111 4.05e-02 131 4 1 0.250 0.008 TF:M03931_0 tf 1 Factor: ZIC3; motif: GACCCCCCGCTGYGN; match class: 0 1 Q9P206 111 4.10e-02 4858 4 4 1.000 0.001 HPA:040030_01 hpa 1 soft tissue 2; fibroblasts[Uncertain,Low] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 4.12e-02 2952 4 3 0.750 0.001 TF:M00454_0 tf 1 Factor: MRF2; motif: AWSCACAATACNVA; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206 111 4.15e-02 134 4 1 0.250 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 Q9P206 111 4.15e-02 4872 4 4 1.000 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 4.18e-02 135 4 1 0.250 0.007 TF:M03904_0 tf 1 Factor: GLIS2; motif: GACCCCCCGCRANG; match class: 0 1 Q9P206 111 4.39e-02 142 4 1 0.250 0.007 TF:M07048_0 tf 1 Factor: MafG; motif: CMATGACTCAGCAGA; match class: 0 1 Q9P206 111 4.39e-02 142 4 1 0.250 0.007 TF:M00938_1 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 1 Q9P206 111 4.41e-02 37 4 1 0.250 0.027 GO:0051492 BP 1 regulation of stress fiber assembly 1 Q9Y6W5 111 4.43e-02 4954 4 4 1.000 0.001 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8 111 4.45e-02 3035 4 3 0.750 0.001 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 4.50e-02 2585 4 3 0.750 0.001 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 Q8IZP0,Q9P206,Q9UQB8 111 4.51e-02 3049 4 3 0.750 0.001 TF:M01219_0 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 0 1 Q8IZP0,Q9P206,Q9UQB8 111 4.59e-02 3068 4 3 0.750 0.001 TF:M00444_1 tf 1 Factor: VDR; motif: GGGKNARNRRGGWSA; match class: 1 1 Q8IZP0,Q9P206,Q9UQB8 111 4.77e-02 3111 4 3 0.750 0.001 TF:M03866_0 tf 1 Factor: c-Fos:c-Jun; motif: NTGACTCAN; match class: 0 1 Q8IZP0,Q9Y6W5,Q9P206 111 4.82e-02 1219 4 2 0.500 0.002 TF:M07437_1 tf 1 Factor: ZBTB2; motif: TCCKCCTSR; match class: 1 1 Q8IZP0,Q9Y6W5 111 4.84e-02 157 4 1 0.250 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q9UQB8 111 4.87e-02 158 4 1 0.250 0.006 TF:M06398_0 tf 1 Factor: ZNF761; motif: GGKWAATCAGA; match class: 0 1 Q9Y6W5 111 4.87e-02 158 4 1 0.250 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 Q8IZP0 111 4.93e-02 160 4 1 0.250 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q9UQB8 111 5.00e-02 175 4 2 0.500 0.011 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 Q9Y6W5,Q9UQB8 111 5.00e-02 2 4 1 0.250 0.500 CORUM:2297 cor 1 ABI1-WASL complex 1 Q8IZP0 111 5.00e-02 1575 4 3 0.750 0.002 REAC:162582 rea 1 Signal Transduction 1 Q8IZP0,Q9Y6W5,Q9UQB8 112 1.73e-03 11 2 1 0.500 0.091 TF:M06097_0 tf 1 Factor: ZNF14; motif: KGTTRGAGRACM; match class: 0 1 Q9Y2B0 112 5.18e-03 33 2 1 0.500 0.030 TF:M07307_1 tf 1 Factor: Sox18; motif: ACAAWGBSNNN; match class: 1 1 P07602 112 6.14e-03 3 2 1 0.500 0.333 GO:0060742 BP 1 epithelial cell differentiation involved in prostate gland development 1 P07602 112 6.14e-03 3 2 1 0.500 0.333 GO:0045716 BP 1 positive regulation of low-density lipoprotein particle receptor biosynthetic process 1 Q9Y2B0 112 6.14e-03 3 2 1 0.500 0.333 GO:0060736 BP 1 prostate gland growth 1 P07602 112 8.19e-03 4 2 1 0.500 0.250 GO:0010988 BP 1 regulation of low-density lipoprotein particle clearance 1 Q9Y2B0 112 8.62e-03 1182 2 2 1.000 0.002 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 P07602,Q9Y2B0 112 9.17e-03 1219 2 2 1.000 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 P07602,Q9Y2B0 112 1.02e-02 5 2 1 0.500 0.200 GO:0010984 BP 1 regulation of lipoprotein particle clearance 1 Q9Y2B0 112 1.07e-02 68 2 1 0.500 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 Q9Y2B0 112 1.23e-02 6 2 1 0.500 0.167 GO:0045714 BP 1 regulation of low-density lipoprotein particle receptor biosynthetic process 1 Q9Y2B0 112 1.23e-02 6 2 1 0.500 0.167 GO:0045713 BP 1 low-density lipoprotein particle receptor biosynthetic process 1 Q9Y2B0 112 1.43e-02 7 2 1 0.500 0.143 GO:0030850 BP 1 prostate gland development 1 P07602 112 1.58e-02 1598 2 2 1.000 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 P07602,Q9Y2B0 112 1.83e-02 117 2 1 0.500 0.009 TF:M00225_0 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 0 1 Q9Y2B0 112 1.83e-02 117 2 1 0.500 0.009 TF:M06285_0 tf 1 Factor: ZNF124; motif: NGGTACTTGGGA; match class: 0 1 Q9Y2B0 112 1.84e-02 9 2 1 0.500 0.111 GO:0010870 BP 1 positive regulation of receptor biosynthetic process 1 Q9Y2B0 112 1.92e-02 123 2 1 0.500 0.008 TF:M06483_0 tf 1 Factor: ZNF595; motif: NGTGGAGGAWGC; match class: 0 1 Q9Y2B0 112 1.94e-02 124 2 1 0.500 0.008 TF:M05825_0 tf 1 Factor: ZNF572; motif: NGGTAGDGAAGC; match class: 0 1 P07602 112 2.05e-02 10 2 1 0.500 0.100 GO:0034383 BP 1 low-density lipoprotein particle clearance 1 Q9Y2B0 112 2.05e-02 10 2 1 0.500 0.100 GO:0032799 BP 1 low-density lipoprotein receptor particle metabolic process 1 Q9Y2B0 112 2.13e-02 136 2 1 0.500 0.007 TF:M06262_0 tf 1 Factor: ZNF415; motif: NGGGGAAWCAGA; match class: 0 1 Q9Y2B0 112 2.38e-02 1962 2 2 1.000 0.001 TF:M01595_0 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 0 1 P07602,Q9Y2B0 112 2.51e-02 2018 2 2 1.000 0.001 TF:M00658_1 tf 1 Factor: PU.1; motif: WGAGGAAG; match class: 1 1 P07602,Q9Y2B0 112 2.55e-02 2032 2 2 1.000 0.001 TF:M07375_0 tf 1 Factor: BCL-6; motif: TTCCTAGAAA; match class: 0 1 P07602,Q9Y2B0 112 2.71e-02 39 2 1 0.500 0.026 REAC:375276 rea 1 Peptide ligand-binding receptors 1 P07602 112 2.71e-02 39 2 1 0.500 0.026 REAC:1660662 rea 1 Glycosphingolipid metabolism 1 P07602 112 2.73e-02 175 2 1 0.500 0.006 TF:M07228_0 tf 1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 0 1 Q9Y2B0 112 2.84e-02 2144 2 2 1.000 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 P07602,Q9Y2B0 112 2.85e-02 2151 2 2 1.000 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 P07602,Q9Y2B0 112 2.87e-02 14 2 1 0.500 0.071 GO:0010869 BP 1 regulation of receptor biosynthetic process 1 Q9Y2B0 112 2.98e-02 191 2 1 0.500 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 P07602 112 3.07e-02 15 2 1 0.500 0.067 GO:0034381 BP 1 plasma lipoprotein particle clearance 1 Q9Y2B0 112 3.18e-02 2270 2 2 1.000 0.001 TF:M01739_0 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 0 1 P07602,Q9Y2B0 112 3.27e-02 16 2 1 0.500 0.062 GO:0032800 BP 1 receptor biosynthetic process 1 Q9Y2B0 112 3.54e-02 227 2 1 0.500 0.004 TF:M00465_0 tf 1 Factor: POU6F1; motif: GCATAAWTTAT; match class: 0 1 Q9Y2B0 112 3.78e-02 243 2 1 0.500 0.004 TF:M00641_0 tf 1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 0 1 Q9Y2B0 112 3.94e-02 253 2 1 0.500 0.004 TF:M05528_0 tf 1 Factor: ZAC; motif: KGWTGGGSAT; match class: 0 1 Q9Y2B0 112 4.12e-02 265 2 1 0.500 0.004 TF:M01260_1 tf 1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 1 Q9Y2B0 112 4.57e-02 294 2 1 0.500 0.003 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 P07602 112 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 P07602,Q9Y2B0 112 4.80e-02 309 2 1 0.500 0.003 TF:M05390_0 tf 1 Factor: TBPL2; motif: CTTTTAAATC; match class: 0 1 P07602 112 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-744* mi 1 MI:hsa-miR-744* 1 Q9Y2B0 112 4.81e-02 2793 2 2 1.000 0.001 TF:M03847_0 tf 1 Factor: Sox15; motif: ACAAWGGG; match class: 0 1 P07602,Q9Y2B0 112 4.85e-02 2804 2 2 1.000 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 P07602,Q9Y2B0 112 5.00e-02 751 2 2 1.000 0.003 GO:0009888 BP 1 tissue development 1 P07602,Q9Y2B0 112 5.00e-02 1 2 1 0.500 1.000 OMIM:249900 omi 1 METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY;;METACHROMATIC LEUKODYSTROPHY DUE TO CEREBROSIDE SULFATASE ACTIVATORDEFICIENCY;;SAPOSIN B DEFICIENCY 1 P07602 112 5.00e-02 1 2 1 0.500 1.000 OMIM:610539 omi 1 GAUCHER DISEASE, ATYPICAL, DUE TO SAPOSIN C DEFICIENCY 1 P07602 112 5.00e-02 161 2 2 1.000 0.012 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 P07602,Q9Y2B0 112 5.00e-02 2 2 1 0.500 0.500 HP:0011169 hp 1 Generalized clonic seizures 1 P07602 112 5.00e-02 1 2 1 0.500 1.000 OMIM:611721 omi 1 COMBINED SAPOSIN DEFICIENCY;;PROSAPOSIN DEFICIENCY; PSAPD;;COMBINED SAP DEFICIENCY 1 P07602 112 5.00e-02 1 2 1 0.500 1.000 OMIM:611722 omi 1 KRABBE DISEASE, ATYPICAL, DUE TO SAPOSIN A DEFICIENCY;;SAPOSIN A DEFICIENCY 1 P07602 112 5.00e-02 72 2 1 0.500 0.014 REAC:428157 rea 1 Sphingolipid metabolism 1 P07602 112 5.00e-02 111 2 1 0.500 0.009 KEGG:04142 keg 1 Lysosome 1 P07602 113 1.44e-04 7 4 2 0.500 0.286 HP:0007549 hp 1 Desquamation of skin soon after birth 1 P22735,O75342 113 1.44e-04 7 4 2 0.500 0.286 HP:0040162 hp 1 Orthokeratosis 1 P22735,O75342 113 4.51e-04 12 4 2 0.500 0.167 HP:0001820 hp 1 Leukonychia 1 P22735,O75342 113 6.21e-04 14 4 2 0.500 0.143 HP:0001927 hp 1 Acanthocytosis 1 P22735,O75342 113 7.16e-04 15 4 2 0.500 0.133 HP:0007479 hp 1 Congenital nonbullous ichthyosiform erythroderma 1 P22735,O75342 113 8.18e-04 16 4 2 0.500 0.125 HP:0001036 hp 1 Parakeratosis 1 P22735,O75342 113 8.18e-04 16 4 2 0.500 0.125 HP:0001816 hp 1 Thin nail 1 P22735,O75342 113 1.04e-03 18 4 2 0.500 0.111 HP:0100643 hp 1 Abnormality of nail color 1 P22735,O75342 113 1.04e-03 18 4 2 0.500 0.111 HP:0100758 hp 1 Gangrene 1 P22735,O75342 113 1.43e-03 21 4 2 0.500 0.095 HP:0000656 hp 1 Ectropion 1 P22735,O75342 113 1.57e-03 22 4 2 0.500 0.091 HP:0007431 hp 1 Congenital ichthyosiform erythroderma 1 P22735,O75342 113 1.57e-03 22 4 2 0.500 0.091 HP:0001438 hp 1 Abnormality of the abdomen 1 P22735,O75342 113 1.72e-03 23 4 2 0.500 0.087 HP:0001006 hp 1 Hypotrichosis 1 P22735,O75342 113 2.56e-03 28 4 2 0.500 0.071 HP:0001019 hp 1 Erythroderma 1 P22735,O75342 113 3.15e-03 31 4 2 0.500 0.065 HP:0004447 hp 1 Poikilocytosis 1 P22735,O75342 113 3.79e-03 34 4 2 0.500 0.059 HP:0200020 hp 1 Corneal erosion 1 P22735,O75342 113 4.49e-03 37 4 2 0.500 0.054 HP:0100679 hp 1 Lack of skin elasticity 1 P22735,O75342 113 4.74e-03 38 4 2 0.500 0.053 HP:0100806 hp 1 Sepsis 1 P22735,O75342 113 5.79e-03 42 4 2 0.500 0.048 HP:0000966 hp 1 Hypohidrosis 1 P22735,O75342 113 6.46e-03 78 4 2 0.500 0.026 GO:0043588 BP 1 skin development 1 P22735,O75342 113 7.17e-03 1 4 1 0.250 1.000 OMIM:242100 omi 1 ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2; ARCI2;;COLLODION BABY, SELF-HEALING;;ICHTHYOSIFORM ERYTHRODERMA, NONBULLOUS CONGENITAL, 1, FORMERLY; NCIE1,FORMERLY;;ICHTHYOSIFORM ERYTHRODERMA, BROCQ CONGENITAL, NONBULLOUS FORM, FORMERLY 1 O75342 113 7.86e-03 5 4 1 0.250 0.200 REAC:2142712 rea 1 Synthesis of 12-eicosatetraenoic acid derivatives 1 O75342 113 8.34e-03 1 4 1 0.250 1.000 GO:0070255 BP 1 regulation of mucus secretion 1 O75342 113 8.34e-03 1 4 1 0.250 1.000 GO:0070257 BP 1 positive regulation of mucus secretion 1 O75342 113 8.34e-03 1 4 1 0.250 1.000 GO:1990136 MF 1 linoleate 9S-lipoxygenase activity 1 O75342 113 8.54e-03 51 4 2 0.500 0.039 HP:0001944 hp 1 Dehydration 1 P22735,O75342 113 1.03e-02 56 4 2 0.500 0.036 HP:0001217 hp 1 Clubbing 1 P22735,O75342 113 1.14e-02 59 4 2 0.500 0.034 HP:0011495 hp 1 Abnormality of corneal epithelium 1 P22735,O75342 113 1.18e-02 60 4 2 0.500 0.033 HP:0000989 hp 1 Pruritus 1 P22735,O75342 113 1.47e-02 67 4 2 0.500 0.030 HP:0003470 hp 1 Paralysis 1 P22735,O75342 113 2.14e-02 81 4 2 0.500 0.025 HP:0008404 hp 1 Nail dystrophy 1 P22735,O75342 113 2.35e-02 85 4 2 0.500 0.024 HP:0011039 hp 1 Abnormality of the helix 1 P22735,O75342 113 2.41e-02 86 4 2 0.500 0.023 HP:0001792 hp 1 Small nail 1 P22735,O75342 113 2.50e-02 3 4 1 0.250 0.333 GO:0043163 BP 1 cell envelope organization 1 P22735 113 2.50e-02 3 4 1 0.250 0.333 GO:0004052 MF 1 arachidonate 12-lipoxygenase activity 1 O75342 113 2.50e-02 3 4 1 0.250 0.333 GO:0045229 BP 1 external encapsulating structure organization 1 P22735 113 2.63e-02 90 4 2 0.500 0.022 HP:0008064 hp 1 Ichthyosis 1 P22735,O75342 113 2.99e-02 802 4 2 0.500 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q96FQ6,Q9HCY8 113 3.05e-02 97 4 2 0.500 0.021 HP:0100840 hp 1 Aplasia/Hypoplasia of the eyebrow 1 P22735,O75342 113 3.11e-02 98 4 2 0.500 0.020 HP:0001831 hp 1 Short toe 1 P22735,O75342 113 3.11e-02 98 4 2 0.500 0.020 HP:0000232 hp 1 Everted lower lip vermilion 1 P22735,O75342 113 3.23e-02 100 4 2 0.500 0.020 HP:0012472 hp 1 Eclabion 1 P22735,O75342 113 3.33e-02 4 4 1 0.250 0.250 GO:0070254 BP 1 mucus secretion 1 O75342 113 3.56e-02 879 4 2 0.500 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q96FQ6,Q9HCY8 113 3.65e-02 186 4 2 0.500 0.011 GO:0005509 MF 1 calcium ion binding 1 Q96FQ6,Q9HCY8 113 3.69e-02 107 4 2 0.500 0.019 HP:0000982 hp 1 Palmoplantar keratoderma 1 P22735,O75342 113 3.83e-02 109 4 2 0.500 0.018 HP:0000958 hp 1 Dry skin 1 P22735,O75342 113 3.97e-02 111 4 2 0.500 0.018 HP:0001991 hp 1 Aplasia/Hypoplasia of toe 1 P22735,O75342 113 4.17e-02 5 4 1 0.250 0.200 GO:0003810 MF 1 protein-glutamine gamma-glutamyltransferase activity 1 P22735 113 4.17e-02 5 4 1 0.250 0.200 GO:0051122 BP 1 hepoxilin biosynthetic process 1 O75342 113 4.17e-02 5 4 1 0.250 0.200 GO:0051121 BP 1 hepoxilin metabolic process 1 O75342 113 4.32e-02 116 4 2 0.500 0.017 HP:0100533 hp 1 Inflammatory abnormality of the eye 1 P22735,O75342 113 4.40e-02 117 4 2 0.500 0.017 HP:0002164 hp 1 Nail dysplasia 1 P22735,O75342 113 5.00e-02 36 4 1 0.250 0.028 KEGG:00590 keg 1 Arachidonic acid metabolism 1 O75342 113 5.00e-02 32 4 1 0.250 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 O75342 113 5.00e-02 435 4 3 0.750 0.007 MI:hsa-miR-671-3p mi 1 MI:hsa-miR-671-3p 1 P22735,Q96FQ6,Q9HCY8 113 5.00e-02 80 4 2 0.500 0.025 TF:M07281_1 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 1 1 Q96FQ6,Q9HCY8 113 5.00e-02 7 4 1 0.250 0.143 OMIM:242300 omi 1 Autosomal Recessive Congenital Ichthyosis 1 P22735 113 5.00e-02 6 4 1 0.250 0.167 GO:0010838 BP 1 positive regulation of keratinocyte proliferation 1 P22735 114 1.13e-05 10 4 2 0.500 0.200 GO:0000815 CC 1 ESCRT III complex 1 Q96CF2,Q7LBR1 114 1.54e-05 130 4 3 0.750 0.023 GO:1902115 BP 1 regulation of organelle assembly 1 Q9ULP9,Q96CF2,Q7LBR1 114 1.95e-05 13 4 2 0.500 0.154 GO:1901673 BP 1 regulation of mitotic spindle assembly 1 Q96CF2,Q7LBR1 114 2.63e-05 15 4 2 0.500 0.133 GO:0090169 BP 1 regulation of spindle assembly 1 Q96CF2,Q7LBR1 114 3.40e-05 17 4 2 0.500 0.118 GO:0000920 BP 1 cell separation after cytokinesis 1 Q96CF2,Q7LBR1 114 4.75e-05 20 4 2 0.500 0.100 GO:0060236 BP 1 regulation of mitotic spindle organization 1 Q96CF2,Q7LBR1 114 5.78e-05 22 4 2 0.500 0.091 GO:0039702 BP 1 viral budding via host ESCRT complex 1 Q96CF2,Q7LBR1 114 5.78e-05 22 4 2 0.500 0.091 GO:0090224 BP 1 regulation of spindle organization 1 Q96CF2,Q7LBR1 114 7.50e-05 25 4 2 0.500 0.080 GO:0036452 CC 1 ESCRT complex 1 Q96CF2,Q7LBR1 114 7.50e-05 25 4 2 0.500 0.080 GO:0046755 BP 1 viral budding 1 Q96CF2,Q7LBR1 114 7.50e-05 25 4 2 0.500 0.080 GO:1902590 BP 1 multi-organism organelle organization 1 Q96CF2,Q7LBR1 114 7.50e-05 25 4 2 0.500 0.080 GO:1902592 BP 1 multi-organism membrane budding 1 Q96CF2,Q7LBR1 114 1.01e-04 29 4 2 0.500 0.069 GO:0010824 BP 1 regulation of centrosome duplication 1 Q96CF2,Q7LBR1 114 1.09e-04 30 4 2 0.500 0.067 GO:0036258 BP 1 multivesicular body assembly 1 Q96CF2,Q7LBR1 114 1.09e-04 30 4 2 0.500 0.067 GO:0044803 BP 1 multi-organism membrane organization 1 Q96CF2,Q7LBR1 114 1.16e-04 31 4 2 0.500 0.065 GO:0036257 BP 1 multivesicular body organization 1 Q96CF2,Q7LBR1 114 1.49e-04 35 4 2 0.500 0.057 GO:0046605 BP 1 regulation of centrosome cycle 1 Q96CF2,Q7LBR1 114 1.57e-04 36 4 2 0.500 0.056 GO:0019068 BP 1 virion assembly 1 Q96CF2,Q7LBR1 114 2.05e-04 41 4 2 0.500 0.049 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q96CF2,Q7LBR1 114 2.81e-04 48 4 2 0.500 0.042 GO:0051310 BP 1 metaphase plate congression 1 Q96CF2,Q7LBR1 114 3.43e-04 53 4 2 0.500 0.038 GO:0090307 BP 1 mitotic spindle assembly 1 Q96CF2,Q7LBR1 114 3.56e-04 54 4 2 0.500 0.037 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 Q96CF2,Q7LBR1 114 3.56e-04 54 4 2 0.500 0.037 GO:0051298 BP 1 centrosome duplication 1 Q96CF2,Q7LBR1 114 3.70e-04 55 4 2 0.500 0.036 GO:0051303 BP 1 establishment of chromosome localization 1 Q96CF2,Q7LBR1 114 3.84e-04 56 4 2 0.500 0.036 GO:0050000 BP 1 chromosome localization 1 Q96CF2,Q7LBR1 114 4.55e-04 61 4 2 0.500 0.033 GO:0007032 BP 1 endosome organization 1 Q96CF2,Q7LBR1 114 5.50e-04 67 4 2 0.500 0.030 GO:0007098 BP 1 centrosome cycle 1 Q96CF2,Q7LBR1 114 6.16e-04 445 4 3 0.750 0.007 GO:0070925 BP 1 organelle assembly 1 Q9ULP9,Q96CF2,Q7LBR1 114 7.08e-04 76 4 2 0.500 0.026 GO:0051225 BP 1 spindle assembly 1 Q96CF2,Q7LBR1 114 8.65e-04 84 4 2 0.500 0.024 GO:0070507 BP 1 regulation of microtubule cytoskeleton organization 1 Q96CF2,Q7LBR1 114 8.92e-04 504 4 3 0.750 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9ULP9,Q96CF2,Q7LBR1 114 9.50e-04 88 4 2 0.500 0.023 GO:0007052 BP 1 mitotic spindle organization 1 Q96CF2,Q7LBR1 114 9.63e-04 1 4 1 0.250 1.000 GO:0008265 MF 1 Mo-molybdopterin cofactor sulfurase activity 1 Q96EN8 114 1.13e-03 96 4 2 0.500 0.021 GO:0006900 BP 1 membrane budding 1 Q96CF2,Q7LBR1 114 1.15e-03 97 4 2 0.500 0.021 GO:0051297 BP 1 centrosome organization 1 Q96CF2,Q7LBR1 114 1.25e-03 101 4 2 0.500 0.020 GO:0007088 BP 1 regulation of mitotic nuclear division 1 Q96CF2,Q7LBR1 114 1.30e-03 103 4 2 0.500 0.019 GO:0006997 BP 1 nucleus organization 1 Q96CF2,Q7LBR1 114 1.33e-03 104 4 2 0.500 0.019 GO:0032886 BP 1 regulation of microtubule-based process 1 Q96CF2,Q7LBR1 114 1.38e-03 106 4 2 0.500 0.019 GO:0031023 BP 1 microtubule organizing center organization 1 Q96CF2,Q7LBR1 114 1.40e-03 107 4 2 0.500 0.019 GO:0051783 BP 1 regulation of nuclear division 1 Q96CF2,Q7LBR1 114 1.56e-03 1 4 1 0.250 1.000 OMIM:614617 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 86; DFNB86 1 Q9ULP9 114 1.56e-03 1 4 1 0.250 1.000 OMIM:616044 omi 1 DEAFNESS, AUTOSOMAL DOMINANT 65; DFNA65 1 Q9ULP9 114 1.56e-03 1 4 1 0.250 1.000 OMIM:615338 omi 1 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 16; EIEE16 1 Q9ULP9 114 1.56e-03 1 4 1 0.250 1.000 OMIM:220500 omi 1 DEAFNESS, ONYCHODYSTROPHY, OSTEODYSTROPHY, MENTAL RETARDATION, ANDSEIZURES SYNDROME; DOORS;;DOOR SYNDROME;;DIGITORENOCEREBRAL SYNDROME;;DRC SYNDROME;;BRACHYDACTYLY DUE TO ABSENCE OF DISTAL PHALANGES;;ERONEN SYNDROME 1 Q9ULP9 114 1.56e-03 1 4 1 0.250 1.000 OMIM:605021 omi 1 MYOCLONIC EPILEPSY, FAMILIAL INFANTILE; FIME;;EIM 1 Q9ULP9 114 1.74e-03 119 4 2 0.500 0.017 GO:0000070 BP 1 mitotic sister chromatid segregation 1 Q96CF2,Q7LBR1 114 1.85e-03 123 4 2 0.500 0.016 GO:0007051 BP 1 spindle organization 1 Q96CF2,Q7LBR1 114 2.43e-03 707 4 3 0.750 0.004 GO:0033043 BP 1 regulation of organelle organization 1 Q9ULP9,Q96CF2,Q7LBR1 114 3.37e-03 166 4 2 0.500 0.012 GO:0051301 BP 1 cell division 1 Q96CF2,Q7LBR1 114 4.68e-03 196 4 2 0.500 0.010 GO:0000819 BP 1 sister chromatid segregation 1 Q96CF2,Q7LBR1 114 4.81e-03 5 4 1 0.250 0.200 GO:0090611 BP 1 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway 1 Q96CF2 114 4.83e-03 199 4 2 0.500 0.010 GO:0010008 CC 1 endosome membrane 1 Q96CF2,Q7LBR1 114 5.78e-03 6 4 1 0.250 0.167 GO:0051189 BP 1 prosthetic group metabolic process 1 Q96EN8 114 5.78e-03 6 4 1 0.250 0.167 GO:0009838 BP 1 abscission 1 Q96CF2 114 5.78e-03 6 4 1 0.250 0.167 GO:0043545 BP 1 molybdopterin cofactor metabolic process 1 Q96EN8 114 5.78e-03 6 4 1 0.250 0.167 GO:0032324 BP 1 molybdopterin cofactor biosynthetic process 1 Q96EN8 114 5.78e-03 6 4 1 0.250 0.167 GO:0032466 BP 1 negative regulation of cytokinesis 1 Q96CF2 114 6.21e-03 226 4 2 0.500 0.009 GO:0098813 BP 1 nuclear chromosome segregation 1 Q96CF2,Q7LBR1 114 6.26e-03 227 4 2 0.500 0.009 GO:0044440 CC 1 endosomal part 1 Q96CF2,Q7LBR1 114 6.74e-03 7 4 1 0.250 0.143 GO:0090543 CC 1 Flemming body 1 Q96CF2 114 6.76e-03 236 4 2 0.500 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q96CF2,Q7LBR1 114 7.43e-03 5 4 1 0.250 0.200 HP:0000800 hp 1 Cystic renal dysplasia 1 Q9ULP9 114 8.38e-03 263 4 2 0.500 0.008 GO:0007059 BP 1 chromosome segregation 1 Q96CF2,Q7LBR1 114 8.50e-03 265 4 2 0.500 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q96CF2,Q7LBR1 114 9.54e-03 281 4 2 0.500 0.007 GO:0016050 BP 1 vesicle organization 1 Q96CF2,Q7LBR1 114 9.62e-03 10 4 1 0.250 0.100 GO:0051782 BP 1 negative regulation of cell division 1 Q96CF2 114 9.62e-03 10 4 1 0.250 0.100 GO:1904903 BP 1 ESCRT III complex disassembly 1 Q7LBR1 114 9.62e-03 10 4 1 0.250 0.100 GO:1904896 BP 1 ESCRT complex disassembly 1 Q7LBR1 114 1.01e-02 289 4 2 0.500 0.007 GO:0051656 BP 1 establishment of organelle localization 1 Q96CF2,Q7LBR1 114 1.04e-02 4 4 1 0.250 0.250 TF:M06564_1 tf 1 Factor: ZNF578; motif: KGGACGKGAAAA; match class: 1 1 Q96EN8 114 1.06e-02 1168 4 3 0.750 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q9ULP9,Q96CF2,Q7LBR1 114 1.15e-02 309 4 2 0.500 0.006 GO:0000280 BP 1 nuclear division 1 Q96CF2,Q7LBR1 114 1.15e-02 2459 4 4 1.000 0.002 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q96EN8,Q9ULP9,Q96CF2,Q7LBR1 114 1.15e-02 12 4 1 0.250 0.083 GO:0046039 BP 1 GTP metabolic process 1 Q96EN8 114 1.15e-02 12 4 1 0.250 0.083 GO:1902188 BP 1 positive regulation of viral release from host cell 1 Q96CF2 114 1.30e-02 1666 4 3 0.750 0.002 HPA:040040_02 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Medium] 1 Q96EN8,Q9ULP9,Q96CF2 114 1.31e-02 330 4 2 0.500 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q96CF2,Q7LBR1 114 1.32e-02 331 4 2 0.500 0.006 GO:0051640 BP 1 organelle localization 1 Q96CF2,Q7LBR1 114 1.35e-02 14 4 1 0.250 0.071 GO:0043195 CC 1 terminal bouton 1 Q9ULP9 114 1.39e-02 340 4 2 0.500 0.006 GO:0048285 BP 1 organelle fission 1 Q96CF2,Q7LBR1 114 1.40e-02 341 4 2 0.500 0.006 GO:0019058 BP 1 viral life cycle 1 Q96CF2,Q7LBR1 114 1.56e-02 6 4 1 0.250 0.167 TF:M06478_0 tf 1 Factor: ZNF433; motif: AGTCCAGATTAC; match class: 0 1 Q96CF2 114 1.58e-02 363 4 2 0.500 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q96CF2,Q7LBR1 114 1.66e-02 373 4 2 0.500 0.005 GO:0016032 BP 1 viral process 1 Q96CF2,Q7LBR1 114 1.68e-02 375 4 2 0.500 0.005 GO:0044764 BP 1 multi-organism cellular process 1 Q96CF2,Q7LBR1 114 1.73e-02 18 4 1 0.250 0.056 GO:1901068 BP 1 guanosine-containing compound metabolic process 1 Q96EN8 114 1.78e-02 386 4 2 0.500 0.005 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q96CF2,Q7LBR1 114 1.78e-02 386 4 2 0.500 0.005 GO:0044419 BP 1 interspecies interaction between organisms 1 Q96CF2,Q7LBR1 114 1.92e-02 20 4 1 0.250 0.050 GO:0031594 CC 1 neuromuscular junction 1 Q9ULP9 114 1.93e-02 402 4 2 0.500 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 Q96CF2,Q7LBR1 114 1.95e-02 404 4 2 0.500 0.005 GO:0010256 BP 1 endomembrane system organization 1 Q96CF2,Q7LBR1 114 1.95e-02 1438 4 3 0.750 0.002 GO:0051128 BP 1 regulation of cellular component organization 1 Q9ULP9,Q96CF2,Q7LBR1 114 2.05e-02 4086 4 4 1.000 0.001 HPA:027020_02 hpa 1 pancreas; islets of Langerhans[Uncertain,Medium] 1 Q96EN8,Q9ULP9,Q96CF2,Q7LBR1 114 2.11e-02 22 4 1 0.250 0.045 GO:0043679 CC 1 axon terminus 1 Q9ULP9 114 2.34e-02 444 4 2 0.500 0.005 GO:0098796 CC 1 membrane protein complex 1 Q96CF2,Q7LBR1 114 2.36e-02 446 4 2 0.500 0.004 GO:0051276 BP 1 chromosome organization 1 Q96CF2,Q7LBR1 114 2.40e-02 25 4 1 0.250 0.040 GO:1902186 BP 1 regulation of viral release from host cell 1 Q96CF2 114 2.50e-02 459 4 2 0.500 0.004 GO:0007017 BP 1 microtubule-based process 1 Q96CF2,Q7LBR1 114 2.57e-02 466 4 2 0.500 0.004 GO:0005768 CC 1 endosome 1 Q96CF2,Q7LBR1 114 2.61e-02 10 4 1 0.250 0.100 TF:M05703_0 tf 1 Factor: ZNF235; motif: NGGGAAAAAASM; match class: 0 1 Q96EN8 114 2.69e-02 28 4 1 0.250 0.036 GO:0044306 CC 1 neuron projection terminus 1 Q9ULP9 114 2.78e-02 29 4 1 0.250 0.034 GO:0052192 BP 1 movement in environment of other organism involved in symbiotic interaction 1 Q96CF2 114 2.78e-02 29 4 1 0.250 0.034 GO:0035891 BP 1 exit from host cell 1 Q96CF2 114 2.78e-02 29 4 1 0.250 0.034 GO:0052126 BP 1 movement in host environment 1 Q96CF2 114 2.78e-02 29 4 1 0.250 0.034 GO:0035890 BP 1 exit from host 1 Q96CF2 114 2.78e-02 29 4 1 0.250 0.034 GO:0019076 BP 1 viral release from host cell 1 Q96CF2 114 2.94e-02 499 4 2 0.500 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q96CF2,Q7LBR1 114 3.19e-02 1706 4 3 0.750 0.002 GO:0022607 BP 1 cellular component assembly 1 Q9ULP9,Q96CF2,Q7LBR1 114 4.16e-02 4876 4 4 1.000 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 Q96EN8,Q9ULP9,Q96CF2,Q7LBR1 114 4.25e-02 29 4 1 0.250 0.034 HP:0008573 hp 1 Low-frequency sensorineural hearing impairment 1 Q9ULP9 114 4.25e-02 29 4 1 0.250 0.034 HP:0008542 hp 1 Low-frequency hearing loss 1 Q9ULP9 114 4.25e-02 29 4 1 0.250 0.034 HP:0040113 hp 1 Old-aged sensorineural hearing impairment 1 Q9ULP9 114 4.25e-02 29 4 1 0.250 0.034 HP:0008615 hp 1 Adult onset sensorineural hearing impairment 1 Q9ULP9 114 4.25e-02 29 4 1 0.250 0.034 HP:0005102 hp 1 Cochlear degeneration 1 Q9ULP9 114 4.39e-02 30 4 1 0.250 0.033 HP:0008596 hp 1 Postlingual sensorineural hearing impairment 1 Q9ULP9 114 4.39e-02 30 4 1 0.250 0.033 HP:0001963 hp 1 Abnormal speech discrimination 1 Q9ULP9 114 4.49e-02 2582 4 3 0.750 0.001 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 Q96EN8,Q9ULP9,Q7LBR1 114 4.56e-02 1932 4 3 0.750 0.002 GO:0044085 BP 1 cellular component biogenesis 1 Q9ULP9,Q96CF2,Q7LBR1 114 4.60e-02 48 4 1 0.250 0.021 GO:1902017 BP 1 regulation of cilium assembly 1 Q9ULP9 114 4.60e-02 48 4 1 0.250 0.021 GO:0033267 CC 1 axon part 1 Q9ULP9 114 4.68e-02 32 4 1 0.250 0.031 HP:0002445 hp 1 Tetraplegia 1 Q9ULP9 114 4.69e-02 49 4 1 0.250 0.020 GO:0032465 BP 1 regulation of cytokinesis 1 Q96CF2 114 4.73e-02 401 4 2 0.500 0.005 TF:M02088_1 tf 1 Factor: E2A; motif: NRMCASCTGCNNN; match class: 1 1 Q96EN8,Q9ULP9 114 4.83e-02 33 4 1 0.250 0.030 HP:0005101 hp 1 High-frequency hearing impairment 1 Q9ULP9 114 4.90e-02 650 4 2 0.500 0.003 GO:0051704 BP 1 multi-organism process 1 Q96CF2,Q7LBR1 114 5.00e-02 6 4 1 0.250 0.167 REAC:947581 rea 1 Molybdenum cofactor biosynthesis 1 Q96EN8 114 5.00e-02 3547 4 4 1.000 0.001 TF:M00413_0 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 0 1 Q96EN8,Q9ULP9,Q96CF2,Q7LBR1 114 5.00e-02 10 4 2 0.500 0.200 CORUM:1186 cor 1 ESCRT-III complex 1 Q96CF2,Q7LBR1 114 5.00e-02 229 4 2 0.500 0.009 KEGG:04144 keg 1 Endocytosis 1 Q96CF2,Q7LBR1 114 5.00e-02 657 4 2 0.500 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q96CF2,Q7LBR1 115 1.05e-10 34 4 4 1.000 0.118 GO:0005669 CC 1 transcription factor TFIID complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.20e-09 9 4 3 0.750 0.333 GO:0001075 MF 1 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly 1 Q92750,Q9HBM6,Q16594 115 5.55e-09 89 4 4 1.000 0.045 GO:0090575 CC 1 RNA polymerase II transcription factor complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 6.35e-09 92 4 4 1.000 0.043 GO:0016591 CC 1 DNA-directed RNA polymerase II, holoenzyme 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 9.28e-09 101 4 4 1.000 0.040 GO:0044798 CC 1 nuclear transcription factor complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-08 114 4 4 1.000 0.035 GO:0055029 CC 1 nuclear DNA-directed RNA polymerase complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-08 114 4 4 1.000 0.035 GO:0000428 CC 1 DNA-directed RNA polymerase complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.63e-08 116 4 4 1.000 0.034 GO:0030880 CC 1 RNA polymerase complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.14e-08 18 4 3 0.750 0.167 GO:0000983 MF 1 transcription factor activity, RNA polymerase II core promoter sequence-specific 1 Q92750,Q9HBM6,Q16594 115 4.80e-08 43 4 4 1.000 0.093 KEGG:03022 keg 1 Basal transcription factors 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.28e-08 168 4 4 1.000 0.024 GO:0005667 CC 1 transcription factor complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.00e-07 216 4 4 1.000 0.019 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:73779 rea 1 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1 Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:167161 rea 1 HIV Transcription Initiation 1 Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:76042 rea 1 RNA Polymerase II Transcription Initiation And Promoter Clearance 1 Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:75953 rea 1 RNA Polymerase II Transcription Initiation 1 Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:73776 rea 1 RNA Polymerase II Promoter Escape 1 Q92750,Q9HBM6,Q16594 115 9.62e-07 46 4 3 0.750 0.065 REAC:167162 rea 1 RNA Polymerase II HIV Promoter Escape 1 Q92750,Q9HBM6,Q16594 115 2.96e-06 89 4 3 0.750 0.034 GO:0006368 BP 1 transcription elongation from RNA polymerase II promoter 1 Q92750,Q9HBM6,Q16594 115 3.31e-06 69 4 3 0.750 0.043 REAC:167172 rea 1 Transcription of the HIV genome 1 Q92750,Q9HBM6,Q16594 115 4.99e-06 79 4 3 0.750 0.038 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 Q92750,Q9HBM6,Q16594 115 6.43e-06 115 4 3 0.750 0.026 GO:0006354 BP 1 DNA-templated transcription, elongation 1 Q92750,Q9HBM6,Q16594 115 6.46e-06 86 4 3 0.750 0.035 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q92750,Q9HBM6,Q16594 115 6.90e-06 521 4 4 1.000 0.008 GO:0044451 CC 1 nucleoplasm part 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.31e-06 11 4 2 0.500 0.182 GO:1902166 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q9HBM6,Q16594 115 8.31e-06 11 4 2 0.500 0.182 GO:1902165 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q9HBM6,Q16594 115 9.97e-06 12 4 2 0.500 0.167 GO:0000124 CC 1 SAGA complex 1 Q9HBM6,Q16594 115 1.07e-05 136 4 3 0.750 0.022 GO:0006367 BP 1 transcription initiation from RNA polymerase II promoter 1 Q92750,Q9HBM6,Q16594 115 1.14e-05 139 4 3 0.750 0.022 GO:1901796 BP 1 regulation of signal transduction by p53 class mediator 1 Q92750,Q9HBM6,Q16594 115 1.18e-05 13 4 2 0.500 0.154 GO:1902254 BP 1 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 Q9HBM6,Q16594 115 1.37e-05 14 4 2 0.500 0.143 GO:0033276 CC 1 transcription factor TFTC complex 1 Q9HBM6,Q16594 115 1.37e-05 14 4 2 0.500 0.143 GO:1902253 BP 1 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 1 Q9HBM6,Q16594 115 1.42e-05 624 4 4 1.000 0.006 GO:1990234 CC 1 transferase complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.12e-05 171 4 3 0.750 0.018 GO:0006352 BP 1 DNA-templated transcription, initiation 1 Q92750,Q9HBM6,Q16594 115 2.19e-05 129 4 3 0.750 0.023 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 Q92750,Q9HBM6,Q16594 115 2.58e-05 19 4 2 0.500 0.105 GO:1901797 BP 1 negative regulation of signal transduction by p53 class mediator 1 Q9HBM6,Q16594 115 2.81e-05 140 4 3 0.750 0.021 REAC:162587 rea 1 HIV Life Cycle 1 Q92750,Q9HBM6,Q16594 115 2.81e-05 140 4 3 0.750 0.021 REAC:73857 rea 1 RNA Polymerase II Transcription 1 Q92750,Q9HBM6,Q16594 115 2.83e-05 741 4 4 1.000 0.005 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.83e-05 741 4 4 1.000 0.005 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.17e-05 21 4 2 0.500 0.095 GO:1902230 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 Q9HBM6,Q16594 115 3.17e-05 762 4 4 1.000 0.005 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.45e-05 150 4 3 0.750 0.020 REAC:5633007 rea 1 Regulation of TP53 Activity 1 Q92750,Q9HBM6,Q16594 115 3.68e-05 791 4 4 1.000 0.005 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.71e-05 206 4 3 0.750 0.015 GO:0072331 BP 1 signal transduction by p53 class mediator 1 Q92750,Q9HBM6,Q16594 115 4.16e-05 24 4 2 0.500 0.083 GO:1902229 BP 1 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 1 Q9HBM6,Q16594 115 4.90e-05 26 4 2 0.500 0.077 GO:0042771 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 Q9HBM6,Q16594 115 6.06e-05 896 4 4 1.000 0.004 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 6.55e-05 30 4 2 0.500 0.067 GO:0070461 CC 1 SAGA-type complex 1 Q9HBM6,Q16594 115 6.80e-05 922 4 4 1.000 0.004 GO:0010628 BP 1 positive regulation of gene expression 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.13e-05 933 4 4 1.000 0.004 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.86e-05 956 4 4 1.000 0.004 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.37e-05 971 4 4 1.000 0.004 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 9.15e-05 993 4 4 1.000 0.004 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.07e-04 1033 4 4 1.000 0.004 GO:1902494 CC 1 catalytic complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.07e-04 219 4 3 0.750 0.014 REAC:162906 rea 1 HIV Infection 1 Q92750,Q9HBM6,Q16594 115 1.17e-04 40 4 2 0.500 0.050 GO:2001021 BP 1 negative regulation of response to DNA damage stimulus 1 Q9HBM6,Q16594 115 1.25e-04 309 4 3 0.750 0.010 GO:0000981 MF 1 RNA polymerase II transcription factor activity, sequence-specific DNA binding 1 Q92750,Q9HBM6,Q16594 115 1.36e-04 43 4 2 0.500 0.047 GO:0072332 BP 1 intrinsic apoptotic signaling pathway by p53 class mediator 1 Q9HBM6,Q16594 115 1.56e-04 12 4 2 0.500 0.167 CORUM:514 cor 1 TFIID-beta complex 1 Q9HBM6,Q16594 115 1.56e-04 12 4 2 0.500 0.167 CORUM:485 cor 1 TFIID complex, B-cell specific 1 Q92750,Q16594 115 1.59e-04 335 4 3 0.750 0.009 GO:0008134 MF 1 transcription factor binding 1 Q92750,Q9HBM6,Q16594 115 1.81e-04 1177 4 4 1.000 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.84e-04 50 4 2 0.500 0.040 GO:0004402 MF 1 histone acetyltransferase activity 1 Q9HBM6,Q16594 115 1.92e-04 51 4 2 0.500 0.039 GO:0043966 BP 1 histone H3 acetylation 1 Q9HBM6,Q16594 115 1.92e-04 51 4 2 0.500 0.039 GO:0061733 MF 1 peptide-lysine-N-acetyltransferase activity 1 Q9HBM6,Q16594 115 2.48e-04 58 4 2 0.500 0.034 GO:2001243 BP 1 negative regulation of intrinsic apoptotic signaling pathway 1 Q9HBM6,Q16594 115 2.48e-04 58 4 2 0.500 0.034 GO:0034212 MF 1 peptide N-acetyltransferase activity 1 Q9HBM6,Q16594 115 2.62e-04 396 4 3 0.750 0.008 GO:0003712 MF 1 transcription cofactor activity 1 Q92750,Q9HBM6,Q16594 115 2.75e-04 61 4 2 0.500 0.033 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 Q9HBM6,Q16594 115 3.15e-04 421 4 3 0.750 0.007 GO:0000989 MF 1 transcription factor activity, transcription factor binding 1 Q92750,Q9HBM6,Q16594 115 3.20e-04 17 4 2 0.500 0.118 CORUM:513 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q9HBM6,Q16594 115 3.28e-04 427 4 3 0.750 0.007 GO:0000988 MF 1 transcription factor activity, protein binding 1 Q92750,Q9HBM6,Q16594 115 3.42e-04 68 4 2 0.500 0.029 GO:1905368 CC 1 peptidase complex 1 Q9HBM6,Q16594 115 3.62e-04 70 4 2 0.500 0.029 GO:0009301 BP 1 snRNA transcription 1 Q7Z7C8,Q16594 115 3.62e-04 70 4 2 0.500 0.029 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 Q7Z7C8,Q16594 115 3.68e-04 331 4 3 0.750 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q92750,Q9HBM6,Q16594 115 3.73e-04 71 4 2 0.500 0.028 GO:0008080 MF 1 N-acetyltransferase activity 1 Q9HBM6,Q16594 115 4.20e-04 346 4 3 0.750 0.009 REAC:5663205 rea 1 Infectious disease 1 Q92750,Q9HBM6,Q16594 115 4.50e-04 78 4 2 0.500 0.026 GO:0030307 BP 1 positive regulation of cell growth 1 Q9HBM6,Q16594 115 4.73e-04 80 4 2 0.500 0.025 GO:0016410 MF 1 N-acyltransferase activity 1 Q9HBM6,Q16594 115 4.85e-04 81 4 2 0.500 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q9HBM6,Q16594 115 4.97e-04 82 4 2 0.500 0.024 GO:0016407 MF 1 acetyltransferase activity 1 Q9HBM6,Q16594 115 5.22e-04 84 4 2 0.500 0.024 GO:0016073 BP 1 snRNA metabolic process 1 Q7Z7C8,Q16594 115 5.48e-04 70 4 2 0.500 0.029 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 Q7Z7C8,Q16594 115 5.77e-04 516 4 3 0.750 0.006 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 Q92750,Q9HBM6,Q16594 115 6.13e-04 91 4 2 0.500 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q9HBM6,Q16594 115 6.13e-04 91 4 2 0.500 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q9HBM6,Q16594 115 6.26e-04 92 4 2 0.500 0.022 GO:0098781 BP 1 ncRNA transcription 1 Q7Z7C8,Q16594 115 6.40e-04 93 4 2 0.500 0.022 GO:2001242 BP 1 regulation of intrinsic apoptotic signaling pathway 1 Q9HBM6,Q16594 115 6.74e-04 1635 4 4 1.000 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 6.89e-04 1644 4 4 1.000 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.10e-04 1656 4 4 1.000 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.22e-04 1663 4 4 1.000 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.54e-04 1681 4 4 1.000 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.55e-04 101 4 2 0.500 0.020 GO:0045927 BP 1 positive regulation of growth 1 Q9HBM6,Q16594 115 7.85e-04 103 4 2 0.500 0.019 GO:0016573 BP 1 histone acetylation 1 Q9HBM6,Q16594 115 8.00e-04 104 4 2 0.500 0.019 GO:0050821 BP 1 protein stabilization 1 Q9HBM6,Q16594 115 8.16e-04 105 4 2 0.500 0.019 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q9HBM6,Q16594 115 8.47e-04 107 4 2 0.500 0.019 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q9HBM6,Q16594 115 8.75e-04 1745 4 4 1.000 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.95e-04 110 4 2 0.500 0.018 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q9HBM6,Q16594 115 9.37e-04 1775 4 4 1.000 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.05e-03 119 4 2 0.500 0.017 GO:2001020 BP 1 regulation of response to DNA damage stimulus 1 Q9HBM6,Q16594 115 1.06e-03 120 4 2 0.500 0.017 GO:2001234 BP 1 negative regulation of apoptotic signaling pathway 1 Q9HBM6,Q16594 115 1.14e-03 1865 4 4 1.000 0.002 GO:0006351 BP 1 transcription, DNA-templated 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.16e-03 1872 4 4 1.000 0.002 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.19e-03 127 4 2 0.500 0.016 GO:0006473 BP 1 protein acetylation 1 Q9HBM6,Q16594 115 1.26e-03 671 4 3 0.750 0.004 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 Q92750,Q9HBM6,Q16594 115 1.26e-03 671 4 3 0.750 0.004 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 Q92750,Q9HBM6,Q16594 115 1.29e-03 1923 4 4 1.000 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.44e-03 1976 4 4 1.000 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.45e-03 1980 4 4 1.000 0.002 GO:0032774 BP 1 RNA biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.49e-03 1994 4 4 1.000 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.62e-03 148 4 2 0.500 0.014 GO:0043543 BP 1 protein acylation 1 Q9HBM6,Q16594 115 1.73e-03 2068 4 4 1.000 0.002 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.78e-03 1485 4 4 1.000 0.003 REAC:74160 rea 1 Gene Expression 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.80e-03 2090 4 4 1.000 0.002 GO:0009889 BP 1 regulation of biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.82e-03 157 4 2 0.500 0.013 GO:0016747 MF 1 transferase activity, transferring acyl groups other than amino-acyl groups 1 Q9HBM6,Q16594 115 1.82e-03 2096 4 4 1.000 0.002 GO:0043234 CC 1 protein complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.94e-03 162 4 2 0.500 0.012 GO:0031647 BP 1 regulation of protein stability 1 Q9HBM6,Q16594 115 2.10e-03 169 4 2 0.500 0.012 GO:0097193 BP 1 intrinsic apoptotic signaling pathway 1 Q9HBM6,Q16594 115 2.11e-03 2173 4 4 1.000 0.002 GO:0010468 BP 1 regulation of gene expression 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.18e-03 2192 4 4 1.000 0.002 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.28e-03 176 4 2 0.500 0.011 GO:0016746 MF 1 transferase activity, transferring acyl groups 1 Q9HBM6,Q16594 115 2.32e-03 4 4 1 0.250 0.250 GO:0000125 CC 1 PCAF complex 1 Q16594 115 2.44e-03 628 4 3 0.750 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 Q92750,Q9HBM6,Q16594 115 2.50e-03 2267 4 4 1.000 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.67e-03 2305 4 4 1.000 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.69e-03 2310 4 4 1.000 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.00e-03 2374 4 4 1.000 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.21e-03 922 4 3 0.750 0.003 GO:0003677 MF 1 DNA binding 1 Q92750,Q9HBM6,Q16594 115 3.33e-03 213 4 2 0.500 0.009 GO:2001233 BP 1 regulation of apoptotic signaling pathway 1 Q9HBM6,Q16594 115 3.48e-03 6 4 1 0.250 0.167 GO:0070761 CC 1 pre-snoRNP complex 1 Q16594 115 3.61e-03 222 4 2 0.500 0.009 GO:0001558 BP 1 regulation of cell growth 1 Q9HBM6,Q16594 115 3.65e-03 720 4 3 0.750 0.004 REAC:1643685 rea 1 Disease 1 Q92750,Q9HBM6,Q16594 115 3.73e-03 970 4 3 0.750 0.003 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q92750,Q9HBM6,Q16594 115 3.87e-03 2529 4 4 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 4.07e-03 7 4 1 0.250 0.143 GO:0000492 BP 1 box C/D snoRNP assembly 1 Q16594 115 4.07e-03 7 4 1 0.250 0.143 GO:0000491 BP 1 small nucleolar ribonucleoprotein complex assembly 1 Q16594 115 4.15e-03 238 4 2 0.500 0.008 GO:0003713 MF 1 transcription coactivator activity 1 Q92750,Q16594 115 4.40e-03 1027 4 3 0.750 0.003 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q92750,Q9HBM6,Q16594 115 4.50e-03 2627 4 4 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 4.65e-03 8 4 1 0.250 0.125 GO:0070742 MF 1 C2H2 zinc finger domain binding 1 Q16594 115 5.07e-03 2707 4 4 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 5.45e-03 3 4 1 0.250 0.333 CORUM:478 cor 1 STAGA core complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q16594 115 5.49e-03 2761 4 4 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 5.56e-03 2770 4 4 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 5.72e-03 280 4 2 0.500 0.007 GO:0016049 BP 1 cell growth 1 Q9HBM6,Q16594 115 5.76e-03 281 4 2 0.500 0.007 GO:0016570 BP 1 histone modification 1 Q9HBM6,Q16594 115 5.80e-03 282 4 2 0.500 0.007 GO:0040008 BP 1 regulation of growth 1 Q9HBM6,Q16594 115 6.13e-03 290 4 2 0.500 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q9HBM6,Q16594 115 6.21e-03 292 4 2 0.500 0.007 GO:1902532 BP 1 negative regulation of intracellular signal transduction 1 Q9HBM6,Q16594 115 6.38e-03 296 4 2 0.500 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9HBM6,Q16594 115 6.38e-03 11 4 1 0.250 0.091 GO:0030914 CC 1 STAGA complex 1 Q16594 115 6.40e-03 2869 4 4 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 6.98e-03 2931 4 4 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.54e-03 13 4 1 0.250 0.077 GO:0051457 BP 1 maintenance of protein location in nucleus 1 Q7Z7C8 115 7.63e-03 2997 4 4 1.000 0.001 GO:0080090 BP 1 regulation of primary metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.79e-03 3013 4 4 1.000 0.001 GO:0090304 BP 1 nucleic acid metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.88e-03 3022 4 4 1.000 0.001 GO:0031323 BP 1 regulation of cellular metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 7.90e-03 330 4 2 0.500 0.006 GO:0097190 BP 1 apoptotic signaling pathway 1 Q9HBM6,Q16594 115 8.00e-03 3033 4 4 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.27e-03 3058 4 4 1.000 0.001 GO:0010467 BP 1 gene expression 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.32e-03 3063 4 4 1.000 0.001 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 8.54e-03 434 4 2 0.500 0.005 MI:mmu-miR-434-3p mi 1 MI:mmu-miR-434-3p 1 Q7Z7C8,Q9HBM6 115 8.92e-03 444 4 2 0.500 0.005 MI:hsa-miR-507 mi 1 MI:hsa-miR-507 1 Q92750,Q16594 115 9.06e-03 5 4 1 0.250 0.200 CORUM:1321 cor 1 Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP) 1 Q16594 115 9.06e-03 5 4 1 0.250 0.200 CORUM:3010 cor 1 TFIID subcomplex 1 Q16594 115 9.28e-03 16 4 1 0.250 0.062 GO:0060760 BP 1 positive regulation of response to cytokine stimulus 1 Q16594 115 9.28e-03 16 4 1 0.250 0.062 GO:0032435 BP 1 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1 Q16594 115 9.52e-03 3168 4 4 1.000 0.001 GO:0044428 CC 1 nuclear part 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 9.78e-03 368 4 2 0.500 0.005 GO:0040007 BP 1 growth 1 Q9HBM6,Q16594 115 1.01e-02 473 4 2 0.500 0.004 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 Q7Z7C8,Q16594 115 1.07e-02 487 4 2 0.500 0.004 MI:hsa-miR-301b mi 1 MI:hsa-miR-301b 1 Q92750,Q16594 115 1.07e-02 3263 4 4 1.000 0.001 GO:0019222 BP 1 regulation of metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.10e-02 19 4 1 0.250 0.053 GO:1901799 BP 1 negative regulation of proteasomal protein catabolic process 1 Q16594 115 1.15e-02 507 4 2 0.500 0.004 MI:hsa-miR-454 mi 1 MI:hsa-miR-454 1 Q92750,Q16594 115 1.17e-02 404 4 2 0.500 0.005 GO:0080135 BP 1 regulation of cellular response to stress 1 Q9HBM6,Q16594 115 1.19e-02 515 4 2 0.500 0.004 MI:hsa-miR-301a mi 1 MI:hsa-miR-301a 1 Q92750,Q16594 115 1.20e-02 408 4 2 0.500 0.005 GO:0043066 BP 1 negative regulation of apoptotic process 1 Q9HBM6,Q16594 115 1.22e-02 521 4 2 0.500 0.004 MI:hsa-miR-148a mi 1 MI:hsa-miR-148a 1 Q92750,Q16594 115 1.24e-02 416 4 2 0.500 0.005 GO:0043069 BP 1 negative regulation of programmed cell death 1 Q9HBM6,Q16594 115 1.28e-02 22 4 1 0.250 0.045 GO:0072595 BP 1 maintenance of protein localization in organelle 1 Q7Z7C8 115 1.28e-02 534 4 2 0.500 0.004 MI:hsa-miR-130b mi 1 MI:hsa-miR-130b 1 Q92750,Q16594 115 1.29e-02 3415 4 4 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.33e-02 3443 4 4 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.33e-02 23 4 1 0.250 0.043 GO:0051059 MF 1 NF-kappaB binding 1 Q92750 115 1.33e-02 23 4 1 0.250 0.043 GO:1903051 BP 1 negative regulation of proteolysis involved in cellular protein catabolic process 1 Q16594 115 1.34e-02 432 4 2 0.500 0.005 GO:0001067 MF 1 regulatory region nucleic acid binding 1 Q9HBM6,Q16594 115 1.34e-02 432 4 2 0.500 0.005 GO:0044212 MF 1 transcription regulatory region DNA binding 1 Q9HBM6,Q16594 115 1.34e-02 432 4 2 0.500 0.005 GO:0000975 MF 1 regulatory region DNA binding 1 Q9HBM6,Q16594 115 1.41e-02 1533 4 3 0.750 0.002 GO:0035556 BP 1 intracellular signal transduction 1 Q92750,Q9HBM6,Q16594 115 1.42e-02 3499 4 4 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.44e-02 448 4 2 0.500 0.004 GO:0060548 BP 1 negative regulation of cell death 1 Q9HBM6,Q16594 115 1.44e-02 449 4 2 0.500 0.004 GO:0006325 BP 1 chromatin organization 1 Q9HBM6,Q16594 115 1.51e-02 3554 4 4 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-02 3561 4 4 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-02 3561 4 4 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-02 3561 4 4 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-02 3561 4 4 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.52e-02 1573 4 3 0.750 0.002 GO:0009966 BP 1 regulation of signal transduction 1 Q92750,Q9HBM6,Q16594 115 1.53e-02 3569 4 4 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.56e-02 27 4 1 0.250 0.037 GO:0044665 CC 1 MLL1/2 complex 1 Q16594 115 1.56e-02 27 4 1 0.250 0.037 GO:0071339 CC 1 MLL1 complex 1 Q16594 115 1.62e-02 3620 4 4 1.000 0.001 GO:0009058 BP 1 biosynthetic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.63e-02 9 4 1 0.250 0.111 CORUM:155 cor 1 TFIID complex 1 Q16594 115 1.63e-02 9 4 1 0.250 0.111 CORUM:3009 cor 1 TFIID complex 1 Q16594 115 1.72e-02 492 4 2 0.500 0.004 GO:0034660 BP 1 ncRNA metabolic process 1 Q7Z7C8,Q16594 115 1.74e-02 3681 4 4 1.000 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 1.74e-02 30 4 1 0.250 0.033 GO:1903363 BP 1 negative regulation of cellular protein catabolic process 1 Q16594 115 1.81e-02 10 4 1 0.250 0.100 CORUM:508 cor 1 TFIID complex 1 Q16594 115 1.81e-02 10 4 1 0.250 0.100 CORUM:471 cor 1 PCAF complex 1 Q16594 115 1.81e-02 10 4 1 0.250 0.100 CORUM:477 cor 1 PCAF complex 1 Q16594 115 1.81e-02 10 4 1 0.250 0.100 CORUM:438 cor 1 GCN5-TRRAP histone acetyltransferase complex 1 Q16594 115 1.81e-02 10 4 1 0.250 0.100 CORUM:1401 cor 1 MOF complex 1 Q16594 115 1.88e-02 1691 4 3 0.750 0.002 GO:0010646 BP 1 regulation of cell communication 1 Q92750,Q9HBM6,Q16594 115 1.99e-02 11 4 1 0.250 0.091 CORUM:484 cor 1 TFIID complex 1 Q16594 115 1.99e-02 11 4 1 0.250 0.091 CORUM:463 cor 1 TFIID-beta complex 1 Q16594 115 2.00e-02 1728 4 3 0.750 0.002 GO:0023051 BP 1 regulation of signaling 1 Q92750,Q9HBM6,Q16594 115 2.14e-02 37 4 1 0.250 0.027 GO:0033613 MF 1 activating transcription factor binding 1 Q16594 115 2.17e-02 12 4 1 0.250 0.083 CORUM:469 cor 1 TFIID-beta complex 1 Q16594 115 2.17e-02 12 4 1 0.250 0.083 CORUM:475 cor 1 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q16594 115 2.17e-02 12 4 1 0.250 0.083 CORUM:509 cor 1 TFIID complex 1 Q16594 115 2.30e-02 3948 4 4 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 2.34e-02 13 4 1 0.250 0.077 CORUM:476 cor 1 STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) 1 Q16594 115 2.43e-02 42 4 1 0.250 0.024 GO:0070555 BP 1 response to interleukin-1 1 Q16594 115 2.47e-02 592 4 2 0.500 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q9HBM6,Q16594 115 2.66e-02 46 4 1 0.250 0.022 GO:0045598 BP 1 regulation of fat cell differentiation 1 Q7Z7C8 115 2.70e-02 15 4 1 0.250 0.067 CORUM:492 cor 1 DA complex 1 Q16594 115 2.72e-02 1924 4 3 0.750 0.002 GO:0065008 BP 1 regulation of biological quality 1 Q7Z7C8,Q9HBM6,Q16594 115 2.84e-02 637 4 2 0.500 0.003 GO:0009968 BP 1 negative regulation of signal transduction 1 Q9HBM6,Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:455 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:493 cor 1 DAB complex 1 Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:445 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:462 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:459 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 2.88e-02 16 4 1 0.250 0.062 CORUM:456 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 2.89e-02 50 4 1 0.250 0.020 GO:0031330 BP 1 negative regulation of cellular catabolic process 1 Q16594 115 2.89e-02 50 4 1 0.250 0.020 GO:0002039 MF 1 p53 binding 1 Q16594 115 3.05e-02 661 4 2 0.500 0.003 GO:0010648 BP 1 negative regulation of cell communication 1 Q9HBM6,Q16594 115 3.06e-02 17 4 1 0.250 0.059 CORUM:470 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q16594 115 3.09e-02 665 4 2 0.500 0.003 GO:0023057 BP 1 negative regulation of signaling 1 Q9HBM6,Q16594 115 3.12e-02 54 4 1 0.250 0.019 GO:0051117 MF 1 ATPase binding 1 Q16594 115 3.13e-02 4264 4 4 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.40e-02 59 4 1 0.250 0.017 GO:0042177 BP 1 negative regulation of protein catabolic process 1 Q16594 115 3.49e-02 2101 4 3 0.750 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 Q92750,Q9HBM6,Q16594 115 3.60e-02 720 4 2 0.500 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9HBM6,Q16594 115 3.64e-02 4430 4 4 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q7Z7C8,Q92750,Q9HBM6,Q16594 115 3.66e-02 2136 4 3 0.750 0.001 GO:0003676 MF 1 nucleic acid binding 1 Q92750,Q9HBM6,Q16594 115 3.85e-02 746 4 2 0.500 0.003 GO:0042981 BP 1 regulation of apoptotic process 1 Q9HBM6,Q16594 115 3.92e-02 68 4 1 0.250 0.015 GO:0035097 CC 1 histone methyltransferase complex 1 Q16594 115 3.95e-02 756 4 2 0.500 0.003 GO:0043067 BP 1 regulation of programmed cell death 1 Q9HBM6,Q16594 115 3.97e-02 69 4 1 0.250 0.014 GO:0032507 BP 1 maintenance of protein location in cell 1 Q7Z7C8 115 4.14e-02 775 4 2 0.500 0.003 GO:0048585 BP 1 negative regulation of response to stimulus 1 Q9HBM6,Q16594 115 4.20e-02 73 4 1 0.250 0.014 GO:0045185 BP 1 maintenance of protein location 1 Q7Z7C8 115 4.37e-02 76 4 1 0.250 0.013 GO:0032434 BP 1 regulation of proteasomal ubiquitin-dependent protein catabolic process 1 Q16594 115 4.51e-02 811 4 2 0.500 0.002 GO:0010941 BP 1 regulation of cell death 1 Q9HBM6,Q16594 115 4.54e-02 814 4 2 0.500 0.002 GO:0080134 BP 1 regulation of response to stress 1 Q9HBM6,Q16594 115 4.60e-02 80 4 1 0.250 0.013 GO:0051651 BP 1 maintenance of location in cell 1 Q7Z7C8 115 4.65e-02 26 4 1 0.250 0.038 CORUM:5386 cor 1 MLL1-WDR5 complex 1 Q16594 115 4.72e-02 82 4 1 0.250 0.012 GO:0045444 BP 1 fat cell differentiation 1 Q7Z7C8 115 4.94e-02 86 4 1 0.250 0.012 GO:0009895 BP 1 negative regulation of catabolic process 1 Q16594 115 5.00e-02 3 4 1 0.250 0.333 TF:M04391_1 tf 1 Factor: LHX9; motif: TAATTGCYAATTA; match class: 1 1 Q16594 115 5.00e-02 28 4 1 0.250 0.036 CORUM:1257 cor 1 ALL-1 supercomplex 1 Q16594 115 5.00e-02 1 4 1 0.250 1.000 OMIM:615841 omi 1 SPERMATOGENIC FAILURE 13; SPGF13 1 Q92750 115 5.00e-02 145 4 2 0.500 0.014 KEGG:05168 keg 1 Herpes simplex infection 1 Q92750,Q9HBM6 115 5.00e-02 22 4 1 0.250 0.045 HP:0000027 hp 1 Azoospermia 1 Q92750 116 4.55e-11 18 5 4 0.800 0.222 GO:0042776 BP 1 mitochondrial ATP synthesis coupled proton transport 1 P30049,P56381,P18859,P56134 116 5.77e-11 19 5 4 0.800 0.211 GO:0045259 CC 1 proton-transporting ATP synthase complex 1 P30049,P56381,P18859,P56134 116 5.77e-11 19 5 4 0.800 0.211 GO:0005753 CC 1 mitochondrial proton-transporting ATP synthase complex 1 P30049,P56381,P18859,P56134 116 1.32e-10 23 5 4 0.800 0.174 GO:0015985 BP 1 energy coupled proton transport, down electrochemical gradient 1 P30049,P56381,P18859,P56134 116 1.32e-10 23 5 4 0.800 0.174 GO:0015986 BP 1 ATP synthesis coupled proton transport 1 P30049,P56381,P18859,P56134 116 3.10e-10 16 5 4 0.800 0.250 REAC:163210 rea 1 Formation of ATP by chemiosmotic coupling 1 P30049,P56381,P18859,P56134 116 6.08e-10 33 5 4 0.800 0.121 GO:1902600 BP 1 hydrogen ion transmembrane transport 1 P30049,P56381,P18859,P56134 116 6.89e-10 34 5 4 0.800 0.118 GO:0016469 CC 1 proton-transporting two-sector ATPase complex 1 P30049,P56381,P18859,P56134 116 7.78e-10 35 5 4 0.800 0.114 GO:0006754 BP 1 ATP biosynthetic process 1 P30049,P56381,P18859,P56134 116 9.81e-10 37 5 4 0.800 0.108 GO:0009206 BP 1 purine ribonucleoside triphosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 9.81e-10 37 5 4 0.800 0.108 GO:0009145 BP 1 purine nucleoside triphosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.10e-09 38 5 4 0.800 0.105 GO:0009201 BP 1 ribonucleoside triphosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 3.42e-09 50 5 4 0.800 0.080 GO:0009142 BP 1 nucleoside triphosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 3.71e-09 51 5 4 0.800 0.078 GO:0009168 BP 1 purine ribonucleoside monophosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 3.71e-09 51 5 4 0.800 0.078 GO:0009127 BP 1 purine nucleoside monophosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 4.35e-09 53 5 4 0.800 0.075 GO:0009156 BP 1 ribonucleoside monophosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 4.35e-09 53 5 4 0.800 0.075 GO:0015992 BP 1 proton transport 1 P30049,P56381,P18859,P56134 116 5.06e-09 55 5 4 0.800 0.073 GO:0009124 BP 1 nucleoside monophosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 5.06e-09 55 5 4 0.800 0.073 GO:0006818 BP 1 hydrogen transport 1 P30049,P56381,P18859,P56134 116 6.30e-09 58 5 4 0.800 0.069 GO:0042451 BP 1 purine nucleoside biosynthetic process 1 P30049,P56381,P18859,P56134 116 6.30e-09 58 5 4 0.800 0.069 GO:0046129 BP 1 purine ribonucleoside biosynthetic process 1 P30049,P56381,P18859,P56134 116 7.74e-09 61 5 4 0.800 0.066 GO:1990542 BP 1 mitochondrial transmembrane transport 1 P30049,P56381,P18859,P56134 116 8.22e-09 240 5 5 1.000 0.021 GO:0098662 BP 1 inorganic cation transmembrane transport 1 P30049,P56381,P18859,P28566,P56134 116 1.00e-08 65 5 4 0.800 0.062 GO:0042455 BP 1 ribonucleoside biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.09e-08 254 5 5 1.000 0.020 GO:0098655 BP 1 cation transmembrane transport 1 P30049,P56381,P18859,P28566,P56134 116 1.46e-08 269 5 5 1.000 0.019 GO:0098660 BP 1 inorganic ion transmembrane transport 1 P30049,P56381,P18859,P28566,P56134 116 2.72e-08 83 5 4 0.800 0.048 GO:0009163 BP 1 nucleoside biosynthetic process 1 P30049,P56381,P18859,P56134 116 3.00e-08 85 5 4 0.800 0.047 GO:1901659 BP 1 glycosyl compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 4.51e-08 94 5 4 0.800 0.043 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 P30049,P56381,P18859,P56134 116 8.85e-08 111 5 4 0.800 0.036 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 P30049,P56381,P18859,P56134 116 8.85e-08 111 5 4 0.800 0.036 GO:0098798 CC 1 mitochondrial protein complex 1 P30049,P56381,P18859,P56134 116 9.86e-08 114 5 4 0.800 0.035 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.02e-07 115 5 4 0.800 0.035 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.06e-07 116 5 4 0.800 0.034 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.31e-07 416 5 5 1.000 0.012 GO:0034220 BP 1 ion transmembrane transport 1 P30049,P56381,P18859,P28566,P56134 116 1.58e-07 128 5 4 0.800 0.031 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.74e-07 440 5 5 1.000 0.011 GO:0006812 BP 1 cation transport 1 P30049,P56381,P18859,P28566,P56134 116 1.90e-07 134 5 4 0.800 0.030 GO:0009165 BP 1 nucleotide biosynthetic process 1 P30049,P56381,P18859,P56134 116 2.46e-07 143 5 4 0.800 0.028 GO:0044455 CC 1 mitochondrial membrane part 1 P30049,P56381,P18859,P56134 116 2.83e-07 148 5 4 0.800 0.027 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 4.38e-07 529 5 5 1.000 0.009 GO:0055085 BP 1 transmembrane transport 1 P30049,P56381,P18859,P28566,P56134 116 5.95e-07 178 5 4 0.800 0.022 GO:0046034 BP 1 ATP metabolic process 1 P30049,P56381,P18859,P56134 116 7.57e-07 189 5 4 0.800 0.021 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P30049,P56381,P18859,P56134 116 7.73e-07 190 5 4 0.800 0.021 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P30049,P56381,P18859,P56134 116 8.24e-07 193 5 4 0.800 0.021 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P30049,P56381,P18859,P56134 116 9.70e-07 201 5 4 0.800 0.020 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P30049,P56381,P18859,P56134 116 9.70e-07 201 5 4 0.800 0.020 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P30049,P56381,P18859,P56134 116 9.70e-07 201 5 4 0.800 0.020 GO:0015672 BP 1 monovalent inorganic cation transport 1 P30049,P56381,P18859,P56134 116 9.73e-07 110 5 4 0.800 0.036 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P30049,P56381,P18859,P56134 116 1.01e-06 203 5 4 0.800 0.020 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P30049,P56381,P18859,P56134 116 1.07e-06 206 5 4 0.800 0.019 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P30049,P56381,P18859,P56134 116 1.15e-06 109 5 4 0.800 0.037 KEGG:00190 keg 1 Oxidative phosphorylation 1 P30049,P56381,P18859,P56134 116 1.16e-06 210 5 4 0.800 0.019 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P30049,P56381,P18859,P56134 116 1.37e-06 219 5 4 0.800 0.018 GO:0006839 BP 1 mitochondrial transport 1 P30049,P56381,P18859,P56134 116 1.97e-06 240 5 4 0.800 0.017 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P30049,P56381,P18859,P56134 116 1.98e-06 4 5 2 0.400 0.500 GO:0045261 CC 1 proton-transporting ATP synthase complex, catalytic core F(1) 1 P30049,P56381 116 1.98e-06 4 5 2 0.400 0.500 GO:0000275 CC 1 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) 1 P30049,P56381 116 2.08e-06 243 5 4 0.800 0.016 GO:0042278 BP 1 purine nucleoside metabolic process 1 P30049,P56381,P18859,P56134 116 2.25e-06 733 5 5 1.000 0.007 GO:0006811 BP 1 ion transport 1 P30049,P56381,P18859,P28566,P56134 116 2.36e-06 251 5 4 0.800 0.016 GO:0009119 BP 1 ribonucleoside metabolic process 1 P30049,P56381,P18859,P56134 116 3.30e-06 5 5 2 0.400 0.400 GO:0033178 CC 1 proton-transporting two-sector ATPase complex, catalytic domain 1 P30049,P56381 116 3.68e-06 153 5 4 0.800 0.026 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P30049,P56381,P18859,P56134 116 3.71e-06 281 5 4 0.800 0.014 GO:0009116 BP 1 nucleoside metabolic process 1 P30049,P56381,P18859,P56134 116 4.76e-06 299 5 4 0.800 0.013 GO:1901657 BP 1 glycosyl compound metabolic process 1 P30049,P56381,P18859,P56134 116 4.96e-06 302 5 4 0.800 0.013 GO:0005743 CC 1 mitochondrial inner membrane 1 P30049,P56381,P18859,P56134 116 5.02e-06 303 5 4 0.800 0.013 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P30049,P56381,P18859,P56134 116 5.29e-06 307 5 4 0.800 0.013 GO:0009259 BP 1 ribonucleotide metabolic process 1 P30049,P56381,P18859,P56134 116 6.17e-06 319 5 4 0.800 0.013 GO:0019693 BP 1 ribose phosphate metabolic process 1 P30049,P56381,P18859,P56134 116 6.56e-06 324 5 4 0.800 0.012 GO:0006163 BP 1 purine nucleotide metabolic process 1 P30049,P56381,P18859,P56134 116 6.64e-06 325 5 4 0.800 0.012 GO:0019866 CC 1 organelle inner membrane 1 P30049,P56381,P18859,P56134 116 7.41e-06 334 5 4 0.800 0.012 GO:0090407 BP 1 organophosphate biosynthetic process 1 P30049,P56381,P18859,P56134 116 8.93e-06 350 5 4 0.800 0.011 GO:0072521 BP 1 purine-containing compound metabolic process 1 P30049,P56381,P18859,P56134 116 9.35e-06 354 5 4 0.800 0.011 GO:0016887 MF 1 ATPase activity 1 P30049,P56381,P18859,P56134 116 1.35e-05 388 5 4 0.800 0.010 GO:0009117 BP 1 nucleotide metabolic process 1 P30049,P56381,P18859,P56134 116 1.49e-05 398 5 4 0.800 0.010 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P30049,P56381,P18859,P56134 116 1.51e-05 399 5 4 0.800 0.010 GO:0031966 CC 1 mitochondrial membrane 1 P30049,P56381,P18859,P56134 116 2.11e-05 434 5 4 0.800 0.009 GO:0005740 CC 1 mitochondrial envelope 1 P30049,P56381,P18859,P56134 116 2.31e-05 444 5 4 0.800 0.009 GO:0098796 CC 1 membrane protein complex 1 P30049,P56381,P18859,P56134 116 2.43e-05 450 5 4 0.800 0.009 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P30049,P56381,P18859,P56134 116 2.80e-05 466 5 4 0.800 0.009 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P30049,P56381,P18859,P56134 116 5.52e-05 553 5 4 0.800 0.007 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P30049,P56381,P18859,P56134 116 6.40e-05 574 5 4 0.800 0.007 GO:1902582 BP 1 single-organism intracellular transport 1 P30049,P56381,P18859,P56134 116 6.63e-05 579 5 4 0.800 0.007 GO:0022857 MF 1 transmembrane transporter activity 1 P30049,P56381,P18859,P56134 116 7.14e-05 590 5 4 0.800 0.007 GO:0016462 MF 1 pyrophosphatase activity 1 P30049,P56381,P18859,P56134 116 7.24e-05 592 5 4 0.800 0.007 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P30049,P56381,P18859,P56134 116 7.24e-05 592 5 4 0.800 0.007 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P30049,P56381,P18859,P56134 116 7.93e-05 1493 5 5 1.000 0.003 GO:0051649 BP 1 establishment of localization in cell 1 P30049,P56381,P18859,P28566,P56134 116 8.06e-05 1498 5 5 1.000 0.003 GO:0044765 BP 1 single-organism transport 1 P30049,P56381,P18859,P28566,P56134 116 1.15e-04 665 5 4 0.800 0.006 GO:0031967 CC 1 organelle envelope 1 P30049,P56381,P18859,P56134 116 1.17e-04 668 5 4 0.800 0.006 GO:0031975 CC 1 envelope 1 P30049,P56381,P18859,P56134 116 1.21e-04 674 5 4 0.800 0.006 GO:0044429 CC 1 mitochondrial part 1 P30049,P56381,P18859,P56134 116 1.21e-04 674 5 4 0.800 0.006 GO:0019637 BP 1 organophosphate metabolic process 1 P30049,P56381,P18859,P56134 116 1.32e-04 1652 5 5 1.000 0.003 GO:1902578 BP 1 single-organism localization 1 P30049,P56381,P18859,P28566,P56134 116 1.37e-04 118 5 3 0.600 0.025 KEGG:05012 keg 1 Parkinson's disease 1 P30049,P56381,P18859 116 1.85e-04 750 5 4 0.800 0.005 GO:0005215 MF 1 transporter activity 1 P30049,P56381,P18859,P56134 116 2.06e-04 771 5 4 0.800 0.005 GO:1902580 BP 1 single-organism cellular localization 1 P30049,P56381,P18859,P56134 116 2.23e-04 1836 5 5 1.000 0.003 GO:0051641 BP 1 cellular localization 1 P30049,P56381,P18859,P28566,P56134 116 2.36e-04 798 5 4 0.800 0.005 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P30049,P56381,P18859,P56134 116 2.48e-04 144 5 3 0.600 0.021 KEGG:05010 keg 1 Alzheimer's disease 1 P30049,P56381,P18859 116 3.04e-04 851 5 4 0.800 0.005 GO:0044711 BP 1 single-organism biosynthetic process 1 P30049,P56381,P18859,P56134 116 3.78e-04 166 5 3 0.600 0.018 KEGG:05016 keg 1 Huntington's disease 1 P30049,P56381,P18859 116 4.99e-04 965 5 4 0.800 0.004 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 6.42e-04 1029 5 4 0.800 0.004 GO:0005739 CC 1 mitochondrion 1 P30049,P56381,P18859,P56134 116 8.75e-04 2412 5 5 1.000 0.002 GO:0044425 CC 1 membrane part 1 P30049,P56381,P18859,P28566,P56134 116 1.32e-03 1237 5 4 0.800 0.003 GO:0046907 BP 1 intracellular transport 1 P30049,P56381,P18859,P56134 116 1.39e-03 2644 5 5 1.000 0.002 GO:0006810 BP 1 transport 1 P30049,P56381,P18859,P28566,P56134 116 1.68e-03 2748 5 5 1.000 0.002 GO:0051234 BP 1 establishment of localization 1 P30049,P56381,P18859,P28566,P56134 116 1.77e-03 1333 5 4 0.800 0.003 GO:0044281 BP 1 small molecule metabolic process 1 P30049,P56381,P18859,P56134 116 2.23e-03 1414 5 4 0.800 0.003 GO:0031090 CC 1 organelle membrane 1 P30049,P56381,P18859,P56134 116 3.31e-03 1565 5 4 0.800 0.003 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P30049,P56381,P18859,P56134 116 3.66e-03 1607 5 4 0.800 0.002 GO:0016787 MF 1 hydrolase activity 1 P30049,P56381,P18859,P56134 116 4.76e-03 5 5 1 0.200 0.200 GO:0051378 MF 1 serotonin binding 1 P28566 116 4.76e-03 5 5 1 0.200 0.200 GO:0043176 MF 1 amine binding 1 P28566 116 4.88e-03 3401 5 5 1.000 0.001 GO:0051179 BP 1 localization 1 P30049,P56381,P18859,P28566,P56134 116 5.71e-03 6 5 1 0.200 0.167 GO:0046688 BP 1 response to copper ion 1 P30049 116 5.71e-03 6 5 1 0.200 0.167 GO:0046933 MF 1 proton-transporting ATP synthase activity, rotational mechanism 1 P30049 116 6.33e-03 1851 5 4 0.800 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P30049,P56381,P18859,P56134 116 7.33e-03 1923 5 4 0.800 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 P30049,P56381,P18859,P56134 116 8.74e-03 1048 5 4 0.800 0.004 KEGG:01100 keg 1 Metabolic pathways 1 P30049,P56381,P18859,P56134 116 1.02e-02 2096 5 4 0.800 0.002 GO:0043234 CC 1 protein complex 1 P30049,P56381,P18859,P56134 116 1.05e-02 11 5 1 0.200 0.091 GO:0099589 MF 1 serotonin receptor activity 1 P28566 116 1.05e-02 11 5 1 0.200 0.091 GO:0004993 MF 1 G-protein coupled serotonin receptor activity 1 P28566 116 1.25e-02 1 5 1 0.200 1.000 OMIM:614053 omi 1 MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 3;MC5DN3;;MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, ATP5E TYPE 1 P56381 116 1.34e-02 5 5 1 0.200 0.200 REAC:390666 rea 1 Serotonin receptors 1 P28566 116 1.38e-02 2267 5 4 0.800 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.42e-02 15 5 1 0.200 0.067 GO:0044769 MF 1 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1 P30049 116 1.44e-02 4 5 1 0.200 0.250 HP:0011925 hp 1 Decreased activity of mitochondrial ATP synthase complex 1 P56381 116 1.47e-02 2305 5 4 0.800 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.48e-02 1310 5 3 0.600 0.002 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 P30049,P18859,P28566 116 1.48e-02 2310 5 4 0.800 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.64e-02 2374 5 4 0.800 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 1.71e-02 18 5 1 0.200 0.056 GO:0008227 MF 1 G-protein coupled amine receptor activity 1 P28566 116 1.83e-02 344 5 2 0.400 0.006 GO:0005759 CC 1 mitochondrial matrix 1 P30049,P56381 116 2.18e-02 23 5 1 0.200 0.043 GO:0043531 MF 1 ADP binding 1 P30049 116 2.19e-02 2560 5 4 0.800 0.002 GO:0044710 BP 1 single-organism metabolic process 1 P30049,P56381,P18859,P56134 116 2.21e-02 4600 5 5 1.000 0.001 GO:0016020 CC 1 membrane 1 P30049,P56381,P18859,P28566,P56134 116 2.70e-02 2707 5 4 0.800 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 P30049,P56381,P18859,P56134 116 2.79e-02 311 5 2 0.400 0.006 MI:hsa-miR-431* mi 1 MI:hsa-miR-431* 1 P28566,P56134 116 3.22e-02 34 5 1 0.200 0.029 GO:0021762 BP 1 substantia nigra development 1 P18859 116 3.31e-02 35 5 1 0.200 0.029 GO:0007193 BP 1 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 1 P28566 116 3.41e-02 36 5 1 0.200 0.028 GO:0007200 BP 1 phospholipase C-activating G-protein coupled receptor signaling pathway 1 P28566 116 3.41e-02 36 5 1 0.200 0.028 GO:0048857 BP 1 neural nucleus development 1 P18859 116 3.59e-02 38 5 1 0.200 0.026 GO:0070405 MF 1 ammonium ion binding 1 P28566 116 3.74e-02 14 5 1 0.200 0.071 REAC:375280 rea 1 Amine ligand-binding receptors 1 P28566 116 3.97e-02 42 5 1 0.200 0.024 GO:0019829 MF 1 cation-transporting ATPase activity 1 P30049 116 4.31e-02 389 5 2 0.400 0.005 MI:hsa-miR-92a-2* mi 1 MI:hsa-miR-92a-2* 1 P30049,P56134 116 4.34e-02 46 5 1 0.200 0.022 GO:0030594 MF 1 neurotransmitter receptor activity 1 P28566 116 4.42e-02 394 5 2 0.400 0.005 MI:hsa-miR-567 mi 1 MI:hsa-miR-567 1 P18859,P28566 116 4.55e-02 400 5 2 0.400 0.005 MI:mmu-miR-805 mi 1 MI:mmu-miR-805 1 P18859,P28566 116 4.62e-02 1984 5 3 0.600 0.002 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 P30049,P18859,P28566 116 4.64e-02 404 5 2 0.400 0.005 MI:hsa-miR-126 mi 1 MI:hsa-miR-126 1 P30049,P56134 116 4.68e-02 406 5 2 0.400 0.005 MI:hsa-miR-573 mi 1 MI:hsa-miR-573 1 P18859,P28566 116 4.72e-02 50 5 1 0.200 0.020 GO:0051283 BP 1 negative regulation of sequestering of calcium ion 1 P28566 116 4.72e-02 50 5 1 0.200 0.020 GO:0051209 BP 1 release of sequestered calcium ion into cytosol 1 P28566 116 4.72e-02 50 5 1 0.200 0.020 GO:0051282 BP 1 regulation of sequestering of calcium ion 1 P28566 116 4.78e-02 3 5 1 0.200 0.333 TF:M04494_0 tf 1 Factor: THRA; motif: NTGACCTYATRAGGTCAN; match class: 0 1 P18859 116 4.81e-02 51 5 1 0.200 0.020 GO:0030901 BP 1 midbrain development 1 P18859 116 4.81e-02 51 5 1 0.200 0.020 GO:1902656 BP 1 calcium ion import into cytosol 1 P28566 116 4.81e-02 51 5 1 0.200 0.020 GO:0097553 BP 1 calcium ion transmembrane import into cytosol 1 P28566 116 4.91e-02 416 5 2 0.400 0.005 MI:hsa-miR-644 mi 1 MI:hsa-miR-644 1 P30049,P56381 116 5.00e-02 15 5 4 0.800 0.267 CORUM:563 cor 1 F1F0-ATP synthase (EC 3.6.3.14), mitochondrial 1 P30049,P56381,P18859,P56134 116 5.00e-02 14 5 1 0.200 0.071 HP:0003535 hp 1 3-Methylglutaconic aciduria 1 P56381 116 5.00e-02 53 5 1 0.200 0.019 GO:0015078 MF 1 hydrogen ion transmembrane transporter activity 1 P30049 116 5.00e-02 45 5 1 0.200 0.022 KEGG:04742 keg 1 Taste transduction 1 P28566 116 5.00e-02 420 5 2 0.400 0.005 MI:hsa-miR-651 mi 1 MI:hsa-miR-651 1 P18859,P56134 116 5.00e-02 4 5 1 0.200 0.250 OMIM:604273 omi 1 Mitochondrial Complex V Deficiency 1 P56381 116 5.00e-02 651 5 3 0.600 0.005 TF:M03789_0 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 0 1 P30049,P56381,P28566 116 5.00e-02 1718 5 4 0.800 0.002 REAC:1430728 rea 1 Metabolism 1 P30049,P56381,P18859,P56134 116 5.00e-02 53 5 1 0.200 0.019 GO:0051208 BP 1 sequestering of calcium ion 1 P28566 117 1.25e-03 1 2 1 0.500 1.000 GO:0008482 MF 1 sulfite oxidase activity 1 P51687 117 1.41e-03 9 2 1 0.500 0.111 TF:M05778_0 tf 1 Factor: ZNF311; motif: NRGTAWGAAAGA; match class: 0 1 Q5MJ09 117 3.30e-03 21 2 1 0.500 0.048 TF:M06250_0 tf 1 Factor: ZNF345; motif: NCGGGGTGYYGC; match class: 0 1 P51687 117 5.01e-03 4 2 1 0.500 0.250 GO:0019418 BP 1 sulfide oxidation 1 P51687 117 5.01e-03 4 2 1 0.500 0.250 GO:0070221 BP 1 sulfide oxidation, using sulfide:quinone oxidoreductase 1 P51687 117 8.76e-03 7 2 1 0.500 0.143 GO:0016670 MF 1 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1 P51687 117 9.25e-03 59 2 1 0.500 0.017 TF:M06569_0 tf 1 Factor: ZNF775; motif: NYGGGAAAATW; match class: 0 1 P51687 117 1.00e-02 5 2 1 0.500 0.200 REAC:1614517 rea 1 Sulfide oxidation to sulfate 1 P51687 117 1.19e-02 76 2 1 0.500 0.013 TF:M04087_1 tf 1 Factor: POU4F3; motif: NTGMATWATTAATGNN; match class: 1 1 Q5MJ09 117 1.38e-02 1493 2 2 1.000 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 P51687,Q5MJ09 117 1.40e-02 1507 2 2 1.000 0.001 TF:M07325_1 tf 1 Factor: MaFA; motif: TCTGCTGASCNN; match class: 1 1 P51687,Q5MJ09 117 1.56e-02 1588 2 2 1.000 0.001 TF:M03796_1 tf 1 Factor: MafA; motif: GGTCAGCAGH; match class: 1 1 P51687,Q5MJ09 117 1.71e-02 109 2 1 0.500 0.009 TF:M03934_0 tf 1 Factor: ZBTB18; motif: NATCCAGATGTKN; match class: 0 1 Q5MJ09 117 1.80e-02 9 2 1 0.500 0.111 REAC:1614558 rea 1 Degradation of cysteine and homocysteine 1 P51687 117 1.84e-02 1729 2 2 1.000 0.001 TF:M04027_1 tf 1 Factor: MEIS1; motif: NTGACAN; match class: 1 1 P51687,Q5MJ09 117 1.94e-02 124 2 1 0.500 0.008 TF:M00421_0 tf 1 Factor: MEIS1B:HOXA9; motif: TGACASTTTWAYRR; match class: 0 1 Q5MJ09 117 2.34e-02 150 2 1 0.500 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 Q5MJ09 117 2.45e-02 157 2 1 0.500 0.006 TF:M04404_0 tf 1 Factor: MSX1; motif: NCAATTAAANNSCAATTA; match class: 0 1 Q5MJ09 117 2.64e-02 169 2 1 0.500 0.006 TF:M04085_1 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 1 1 Q5MJ09 117 3.30e-02 212 2 1 0.500 0.005 TF:M04042_1 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 1 1 Q5MJ09 117 3.33e-02 2 2 1 0.500 0.500 HP:0012612 hp 1 Abnormal urinary sulfate concentration 1 P51687 117 3.33e-02 2 2 1 0.500 0.500 HP:0003359 hp 1 Decreased urinary sulfate 1 P51687 117 3.33e-02 2 2 1 0.500 0.500 HP:0011942 hp 1 Increased urinary sulfite 1 P51687 117 3.33e-02 2 2 1 0.500 0.500 HP:0003643 hp 1 Sulfite oxidase deficiency 1 P51687 117 3.70e-02 238 2 1 0.500 0.004 TF:M03793_1 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 1 1 P51687 117 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q5MJ09 117 3.77e-02 2471 2 2 1.000 0.001 TF:M04224_1 tf 1 Factor: NRL; motif: NNNNTGCTGAC; match class: 1 1 P51687,Q5MJ09 117 3.85e-02 2498 2 2 1.000 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 P51687,Q5MJ09 117 3.85e-02 2498 2 2 1.000 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 P51687,Q5MJ09 117 3.94e-02 253 2 1 0.500 0.004 TF:M01044_0 tf 1 Factor: Tbx5; motif: CTCACACCTT; match class: 0 1 Q5MJ09 117 3.97e-02 255 2 1 0.500 0.004 TF:M07337_0 tf 1 Factor: SMAR1; motif: YAAMSTGCTGAK; match class: 0 1 P51687 117 4.01e-02 258 2 1 0.500 0.004 TF:M06576_0 tf 1 Factor: ZNF419; motif: GGGTGGCCGC; match class: 0 1 Q5MJ09 117 4.01e-02 258 2 1 0.500 0.004 TF:M06377_0 tf 1 Factor: ZNF773; motif: GGGTGGCCGC; match class: 0 1 Q5MJ09 117 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 Q5MJ09 117 4.29e-02 2637 2 2 1.000 0.001 TF:M07301_1 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 1 1 P51687,Q5MJ09 117 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 P51687 117 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q5MJ09 117 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 P51687,Q5MJ09 117 4.67e-02 301 2 1 0.500 0.003 TF:M07102_0 tf 1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 0 1 Q5MJ09 117 4.75e-02 306 2 1 0.500 0.003 TF:M03874_0 tf 1 Factor: Hoxa9; motif: ATYAATDACATC; match class: 0 1 Q5MJ09 117 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 P51687 117 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 P51687 117 4.97e-02 320 2 1 0.500 0.003 TF:M07259_1 tf 1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1 Q5MJ09 117 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 Q5MJ09 117 5.00e-02 40 2 1 0.500 0.025 GO:0016667 MF 1 oxidoreductase activity, acting on a sulfur group of donors 1 P51687 117 5.00e-02 398 2 2 1.000 0.005 MI:hsa-miR-302a* mi 1 MI:hsa-miR-302a* 1 P51687,Q5MJ09 117 5.00e-02 3 2 1 0.500 0.333 HP:0007325 hp 1 Generalized dystonia 1 P51687 117 5.00e-02 1 2 1 0.500 1.000 OMIM:272300 omi 1 SULFOCYSTEINURIA;;SULFITE OXIDASE DEFICIENCY 1 P51687 117 5.00e-02 10 2 1 0.500 0.100 KEGG:00920 keg 1 Sulfur metabolism 1 P51687 117 5.00e-02 25 2 1 0.500 0.040 REAC:1614635 rea 1 Sulfur amino acid metabolism 1 P51687 118 8.59e-04 154 4 2 0.500 0.013 TF:M07384_1 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 1 1 Q01664,Q9NTX9 118 1.57e-03 5 4 1 0.250 0.200 TF:M06563_0 tf 1 Factor: ZNF483; motif: NGGWTCGGCCTY; match class: 0 1 Q9Y3R4 118 3.36e-03 1 4 1 0.250 1.000 OMIM:214110 omi 1 PEROXISOME BIOGENESIS DISORDER 2A (ZELLWEGER); PBD2APEROXISOME BIOGENESIS DISORDER, COMPLEMENTATION GROUP 2, INCLUDED;CG2, INCLUDED 1 P50542 118 3.36e-03 1 4 1 0.250 1.000 OMIM:202370 omi 1 PEROXISOME BIOGENESIS DISORDER 2B; PBD2B 1 P50542 118 3.45e-03 11 4 1 0.250 0.091 TF:M06416_0 tf 1 Factor: ZNF429; motif: KGGAATTGGAKM; match class: 0 1 Q9Y3R4 118 4.08e-03 13 4 1 0.250 0.077 TF:M05647_0 tf 1 Factor: HKR1; motif: KGGTGAAAAAGC; match class: 0 1 Q01664 118 4.82e-03 3354 4 4 1.000 0.001 TF:M01860_1 tf 1 Factor: AP-4; motif: NCAGCTGYNGNCN; match class: 1 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 5.56e-03 1 4 1 0.250 1.000 GO:0005052 MF 1 peroxisome matrix targeting signal-1 binding 1 P50542 118 5.65e-03 18 4 1 0.250 0.056 TF:M05574_0 tf 1 Factor: ZFP92; motif: NGGGAMGGCGTC; match class: 0 1 Q9NTX9 118 5.95e-03 1499 4 3 0.750 0.002 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 Q01664,Q9Y3R4,Q9NTX9 118 6.30e-03 1529 4 3 0.750 0.002 TF:M07384_0 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 0 1 Q01664,Q9Y3R4,Q9NTX9 118 8.70e-03 1709 4 3 0.750 0.002 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q01664,Q9Y3R4,Q9NTX9 118 9.15e-03 511 4 2 0.500 0.004 TF:M04428_0 tf 1 Factor: PITX1; motif: NTTAATCCN; match class: 0 1 P50542,Q9NTX9 118 9.40e-03 30 4 1 0.250 0.033 TF:M00993_1 tf 1 Factor: Tal-1; motif: TCCAKCTGNY; match class: 1 1 Q9Y3R4 118 9.71e-03 31 4 1 0.250 0.032 TF:M07095_1 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 1 1 Q01664 118 1.00e-02 32 4 1 0.250 0.031 TF:M06613_0 tf 1 Factor: ZNF514; motif: NGTTGATTMAGM; match class: 0 1 Q9NTX9 118 1.11e-02 2 4 1 0.250 0.500 GO:1901093 BP 1 regulation of protein homotetramerization 1 P50542 118 1.11e-02 2 4 1 0.250 0.500 GO:1901091 BP 1 negative regulation of protein tetramerization 1 P50542 118 1.11e-02 2 4 1 0.250 0.500 GO:1901090 BP 1 regulation of protein tetramerization 1 P50542 118 1.11e-02 2 4 1 0.250 0.500 GO:0052794 MF 1 exo-alpha-(2->3)-sialidase activity 1 Q9Y3R4 118 1.11e-02 2 4 1 0.250 0.500 GO:1901094 BP 1 negative regulation of protein homotetramerization 1 P50542 118 1.16e-02 37 4 1 0.250 0.027 TF:M05993_0 tf 1 Factor: ZNF711; motif: NTGCGTGCGC; match class: 0 1 Q01664 118 1.22e-02 4230 4 4 1.000 0.001 TF:M03867_0 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 1.47e-02 47 4 1 0.250 0.021 TF:M00001_1 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 1 1 Q9Y3R4 118 1.48e-02 10 4 1 0.250 0.100 HP:0008167 hp 1 Very long chain fatty acid accumulation 1 P50542 118 1.48e-02 10 4 1 0.250 0.100 HP:0006894 hp 1 Hypoplastic olfactory lobes 1 P50542 118 1.48e-02 10 4 1 0.250 0.100 HP:0012592 hp 1 Albuminuria 1 P50542 118 1.49e-02 657 4 2 0.500 0.003 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 Q01664,Q9Y3R4 118 1.63e-02 11 4 1 0.250 0.091 HP:0000537 hp 1 Epicanthus inversus 1 P50542 118 1.63e-02 11 4 1 0.250 0.091 HP:0002764 hp 1 Stippled chondral calcification 1 P50542 118 1.63e-02 11 4 1 0.250 0.091 HP:0011040 hp 1 Abnormality of the intrahepatic bile duct 1 P50542 118 1.63e-02 11 4 1 0.250 0.091 HP:0007227 hp 1 Macrogyria 1 P50542 118 1.63e-02 11 4 1 0.250 0.091 HP:0001401 hp 1 Intrahepatic biliary dysgenesis 1 P50542 118 1.67e-02 3 4 1 0.250 0.333 GO:0016560 BP 1 protein import into peroxisome matrix, docking 1 P50542 118 1.67e-02 3 4 1 0.250 0.333 GO:0006689 BP 1 ganglioside catabolic process 1 Q9Y3R4 118 1.68e-02 24 4 1 0.250 0.042 REAC:4085001 rea 1 Sialic acid metabolism 1 Q9Y3R4 118 1.71e-02 621 4 2 0.500 0.003 MI:mmu-miR-466a-3p mi 1 MI:mmu-miR-466a-3p 1 Q9Y3R4,Q9NTX9 118 1.78e-02 12 4 1 0.250 0.083 HP:0001088 hp 1 Brushfield spots 1 P50542 118 1.78e-02 12 4 1 0.250 0.083 HP:0003455 hp 1 Elevated long chain fatty acids 1 P50542 118 1.78e-02 12 4 1 0.250 0.083 HP:0010965 hp 1 Abnormality of phytanic acid metabolism 1 P50542 118 1.78e-02 12 4 1 0.250 0.083 HP:0000244 hp 1 Brachyturricephaly 1 P50542 118 1.78e-02 12 4 1 0.250 0.083 HP:0010571 hp 1 Elevated levels of phytanic acid 1 P50542 118 1.79e-02 4657 4 4 1.000 0.001 TF:M03860_0 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 1.90e-02 2242 4 3 0.750 0.001 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q01664,P50542,Q9NTX9 118 1.91e-02 634 4 2 0.500 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q01664,P50542 118 1.92e-02 13 4 1 0.250 0.077 HP:0002832 hp 1 Calcific stippling 1 P50542 118 1.92e-02 13 4 1 0.250 0.077 HP:0007930 hp 1 Prominent epicanthal folds 1 P50542 118 1.92e-02 13 4 1 0.250 0.077 HP:0005989 hp 1 Redundant neck skin 1 P50542 118 1.92e-02 13 4 1 0.250 0.077 HP:0003159 hp 1 Hyperoxaluria 1 P50542 118 1.93e-02 2257 4 3 0.750 0.001 TF:M04075_1 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 1 1 Q9Y3R4,P50542,Q9NTX9 118 1.95e-02 4756 4 4 1.000 0.001 TF:M00217_0 tf 1 Factor: USF; motif: NCACGTGN; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 2.01e-02 6 4 1 0.250 0.167 OMIM:601539 omi 1 Peroxisome Biogenesis Disorder NALD/IRD 1 P50542 118 2.07e-02 14 4 1 0.250 0.071 HP:0002416 hp 1 Subependymal cysts 1 P50542 118 2.11e-02 2328 4 3 0.750 0.001 TF:M03834_0 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 0 1 Q9Y3R4,P50542,Q9NTX9 118 2.13e-02 792 4 2 0.500 0.003 TF:M07378_1 tf 1 Factor: cdx; motif: NNTTTATNN; match class: 1 1 Q9Y3R4,P50542 118 2.22e-02 15 4 1 0.250 0.067 HP:0004734 hp 1 Renal cortical microcysts 1 P50542 118 2.22e-02 15 4 1 0.250 0.067 HP:0010964 hp 1 Abnormality of long-chain fatty-acid metabolism 1 P50542 118 2.22e-02 808 4 2 0.500 0.002 TF:M01796_0 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 0 1 Q9Y3R4,P50542 118 2.27e-02 73 4 1 0.250 0.014 TF:M03949_1 tf 1 Factor: TFCP2; motif: ACCGGTTNAAACYGGT; match class: 1 1 Q01664 118 2.31e-02 2405 4 3 0.750 0.001 TF:M04071_0 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 0 1 Q9Y3R4,P50542,Q9NTX9 118 2.34e-02 4978 4 4 1.000 0.001 TF:M02023_0 tf 1 Factor: MAZ; motif: NKGGGAGGGGRGGR; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 2.36e-02 16 4 1 0.250 0.062 HP:0008935 hp 1 Generalized neonatal hypotonia 1 P50542 118 2.36e-02 16 4 1 0.250 0.062 HP:0003146 hp 1 Hypocholesterolemia 1 P50542 118 2.36e-02 16 4 1 0.250 0.062 HP:0100593 hp 1 Calcification of cartilage 1 P50542 118 2.42e-02 5021 4 4 1.000 0.001 TF:M07208_0 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 2.51e-02 17 4 1 0.250 0.059 HP:0001093 hp 1 Optic nerve dysplasia 1 P50542 118 2.51e-02 17 4 1 0.250 0.059 HP:0000267 hp 1 Cranial asymmetry 1 P50542 118 2.51e-02 17 4 1 0.250 0.059 HP:0004492 hp 1 Widely patent fontanelles and sutures 1 P50542 118 2.52e-02 2478 4 3 0.750 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q01664,Q9Y3R4,P50542 118 2.58e-02 83 4 1 0.250 0.012 TF:M05381_1 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 1 1 Q01664 118 2.63e-02 884 4 2 0.500 0.002 TF:M02090_0 tf 1 Factor: E2F-4; motif: GCGGGAAANA; match class: 0 1 Q01664,Q9NTX9 118 2.64e-02 85 4 1 0.250 0.012 TF:M00634_1 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 1 1 P50542 118 2.65e-02 18 4 1 0.250 0.056 HP:0000641 hp 1 Dysmetric saccades 1 P50542 118 2.73e-02 39 4 1 0.250 0.026 REAC:1660662 rea 1 Glycosphingolipid metabolism 1 Q9Y3R4 118 2.76e-02 2561 4 3 0.750 0.001 TF:M04154_1 tf 1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 1 1 Q01664,Q9Y3R4,Q9NTX9 118 2.78e-02 5 4 1 0.250 0.200 GO:0004308 MF 1 exo-alpha-sialidase activity 1 Q9Y3R4 118 2.78e-02 5 4 1 0.250 0.200 GO:0045046 BP 1 protein import into peroxisome membrane 1 P50542 118 2.78e-02 5 4 1 0.250 0.200 GO:0032463 BP 1 negative regulation of protein homooligomerization 1 P50542 118 2.78e-02 5 4 1 0.250 0.200 GO:0016997 MF 1 alpha-sialidase activity 1 Q9Y3R4 118 2.78e-02 5 4 1 0.250 0.200 GO:0000268 MF 1 peroxisome targeting sequence binding 1 P50542 118 2.95e-02 20 4 1 0.250 0.050 HP:0000778 hp 1 Hypoplasia of the thymus 1 P50542 118 2.96e-02 5282 4 4 1.000 0.001 TF:M00913_0 tf 1 Factor: MYB; motif: NAACNGNCN; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 2.98e-02 96 4 1 0.250 0.010 TF:M05649_0 tf 1 Factor: ZFY; motif: KGGGGCTGCAGC; match class: 0 1 Q01664 118 2.98e-02 96 4 1 0.250 0.010 TF:M05652_0 tf 1 Factor: ZFX; motif: KGGGGCTGCASC; match class: 0 1 Q01664 118 3.09e-02 2664 4 3 0.750 0.001 TF:M01034_1 tf 1 Factor: Ebox; motif: NCACSTGNCN; match class: 1 1 Q01664,Q9Y3R4,Q9NTX9 118 3.12e-02 2673 4 3 0.750 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 Q01664,Q9Y3R4,Q9NTX9 118 3.12e-02 2673 4 3 0.750 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 Q01664,Q9Y3R4,Q9NTX9 118 3.24e-02 5402 4 4 1.000 0.001 TF:M01104_1 tf 1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 3.28e-02 993 4 2 0.500 0.002 TF:M00001_0 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 0 1 Q01664,Q9Y3R4 118 3.33e-02 6 4 1 0.250 0.167 GO:0015919 BP 1 peroxisomal membrane transport 1 P50542 118 3.33e-02 6 4 1 0.250 0.167 GO:0022615 BP 1 protein to membrane docking 1 P50542 118 3.38e-02 23 4 1 0.250 0.043 HP:0000514 hp 1 Slow saccadic eye movements 1 P50542 118 3.38e-02 23 4 1 0.250 0.043 HP:0100540 hp 1 Palpebral edema 1 P50542 118 3.38e-02 23 4 1 0.250 0.043 HP:0009046 hp 1 Difficulty running 1 P50542 118 3.40e-02 5466 4 4 1.000 0.001 TF:M00470_1 tf 1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 3.56e-02 1037 4 2 0.500 0.002 TF:M07281_0 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 0 1 Q9Y3R4,Q9NTX9 118 3.58e-02 1040 4 2 0.500 0.002 TF:M05882_0 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 0 1 Q9Y3R4,P50542 118 3.63e-02 52 4 1 0.250 0.019 REAC:446219 rea 1 Synthesis of substrates in N-glycan biosythesis 1 Q9Y3R4 118 3.67e-02 25 4 1 0.250 0.040 HP:0011398 hp 1 Central hypotonia 1 P50542 118 3.67e-02 25 4 1 0.250 0.040 HP:0000803 hp 1 Renal cortical cysts 1 P50542 118 3.67e-02 25 4 1 0.250 0.040 HP:0002763 hp 1 Abnormal cartilage morphology 1 P50542 118 3.67e-02 25 4 1 0.250 0.040 HP:0001582 hp 1 Redundant skin 1 P50542 118 3.67e-02 25 4 1 0.250 0.040 HP:0010655 hp 1 Epiphyseal stippling 1 P50542 118 3.67e-02 25 4 1 0.250 0.040 HP:0000262 hp 1 Turricephaly 1 P50542 118 3.70e-02 2840 4 3 0.750 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q9Y3R4,P50542,Q9NTX9 118 3.72e-02 120 4 1 0.250 0.008 TF:M05297_0 tf 1 Factor: Sox-1; motif: TRAATATTWAA; match class: 0 1 P50542 118 3.81e-02 123 4 1 0.250 0.008 TF:M05680_0 tf 1 Factor: ZNF80; motif: NTGGGCTGGGGW; match class: 0 1 Q9Y3R4 118 3.81e-02 123 4 1 0.250 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 Q01664 118 3.82e-02 26 4 1 0.250 0.038 HP:0008947 hp 1 Infantile muscular hypotonia 1 P50542 118 3.82e-02 26 4 1 0.250 0.038 HP:0004359 hp 1 Abnormality of fatty-acid metabolism 1 P50542 118 3.83e-02 1078 4 2 0.500 0.002 TF:M00414_1 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 1 1 Q01664,P50542 118 3.89e-02 7 4 1 0.250 0.143 GO:0043922 BP 1 negative regulation by host of viral transcription 1 Q01664 118 3.89e-02 7 4 1 0.250 0.143 GO:0032460 BP 1 negative regulation of protein oligomerization 1 P50542 118 3.89e-02 7 4 1 0.250 0.143 GO:0046514 BP 1 ceramide catabolic process 1 Q9Y3R4 118 3.89e-02 7 4 1 0.250 0.143 GO:0046479 BP 1 glycosphingolipid catabolic process 1 Q9Y3R4 118 3.89e-02 7 4 1 0.250 0.143 GO:0009313 BP 1 oligosaccharide catabolic process 1 Q9Y3R4 118 4.11e-02 28 4 1 0.250 0.036 HP:0001476 hp 1 Delayed closure of the anterior fontanelle 1 P50542 118 4.17e-02 2966 4 3 0.750 0.001 TF:M01869_0 tf 1 Factor: C/EBPgamma; motif: NRTKRSRMAAKN; match class: 0 1 Q01664,Q9Y3R4,P50542 118 4.25e-02 29 4 1 0.250 0.034 HP:0000627 hp 1 Posterior embryotoxon 1 P50542 118 4.25e-02 29 4 1 0.250 0.034 HP:0002570 hp 1 Steatorrhea 1 P50542 118 4.25e-02 29 4 1 0.250 0.034 HP:0006579 hp 1 Prolonged neonatal jaundice 1 P50542 118 4.35e-02 1153 4 2 0.500 0.002 TF:M01716_0 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 0 1 Q01664,Q9Y3R4 118 4.39e-02 30 4 1 0.250 0.033 HP:0008048 hp 1 Abnormality of the line of Schwalbe 1 P50542 118 4.39e-02 30 4 1 0.250 0.033 HP:0010458 hp 1 Female pseudohermaphroditism 1 P50542 118 4.45e-02 8 4 1 0.250 0.125 GO:0019377 BP 1 glycolipid catabolic process 1 Q9Y3R4 118 4.45e-02 3035 4 3 0.750 0.001 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 Q01664,P50542,Q9NTX9 118 4.46e-02 5849 4 4 1.000 0.001 TF:M00644_1 tf 1 Factor: LBP-1; motif: CAGCTGS; match class: 1 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q01664,P50542 118 4.52e-02 3052 4 3 0.750 0.001 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q01664,Q9Y3R4,P50542 118 4.52e-02 65 4 1 0.250 0.015 REAC:446193 rea 1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 1 Q9Y3R4 118 4.54e-02 31 4 1 0.250 0.032 HP:0000835 hp 1 Adrenal hypoplasia 1 P50542 118 4.54e-02 5876 4 4 1.000 0.001 TF:M00799_0 tf 1 Factor: Myc; motif: CACGTGS; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 4.63e-02 150 4 1 0.250 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 Q9NTX9 118 4.63e-02 1193 4 2 0.500 0.002 TF:M00998_0 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 0 1 Q9Y3R4,P50542 118 4.68e-02 32 4 1 0.250 0.031 HP:0010537 hp 1 Wide cranial sutures 1 P50542 118 4.68e-02 32 4 1 0.250 0.031 HP:0001341 hp 1 Olfactory lobe agenesis 1 P50542 118 4.81e-02 156 4 1 0.250 0.006 TF:M01147_0 tf 1 Factor: DMRT2; motif: NAWWTTGWTACATTGW; match class: 0 1 Q9NTX9 118 4.83e-02 33 4 1 0.250 0.030 HP:0000474 hp 1 Thickened nuchal skin fold 1 P50542 118 4.83e-02 33 4 1 0.250 0.030 HP:0002630 hp 1 Fat malabsorption 1 P50542 118 4.83e-02 5967 4 4 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 4.87e-02 1225 4 2 0.500 0.002 TF:M00807_1 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 1 Q9Y3R4,Q9NTX9 118 4.96e-02 6006 4 4 1.000 0.001 TF:M00189_1 tf 1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 1 Q01664,Q9Y3R4,P50542,Q9NTX9 118 5.00e-02 162 4 1 0.250 0.006 TF:M00249_1 tf 1 Factor: CHOP:C/EBPalpha; motif: NNRTGCAATMCCC; match class: 1 1 Q9Y3R4 118 5.00e-02 72 4 1 0.250 0.014 REAC:428157 rea 1 Sphingolipid metabolism 1 Q9Y3R4 118 5.00e-02 17 4 1 0.250 0.059 KEGG:00511 keg 1 Other glycan degradation 1 Q9Y3R4 118 5.00e-02 15 4 1 0.250 0.067 OMIM:214100 omi 1 Zellweger Syndrome 1 P50542 118 5.00e-02 9 4 1 0.250 0.111 GO:0016558 BP 1 protein import into peroxisome matrix 1 P50542 119 6.25e-03 1 3 1 0.333 1.000 GO:0070138 MF 1 ubiquitin-like protein-specific isopeptidase activity 1 Q5W0Q7 119 6.25e-03 1 3 1 0.333 1.000 GO:0070122 MF 1 isopeptidase activity 1 Q5W0Q7 119 6.25e-03 1 3 1 0.333 1.000 GO:0070140 MF 1 SUMO-specific isopeptidase activity 1 Q5W0Q7 119 1.25e-02 2 3 1 0.333 0.500 GO:0030576 BP 1 Cajal body organization 1 Q5W0Q7 119 1.47e-02 53 3 1 0.333 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q5W0Q7 119 1.69e-02 3 3 1 0.333 0.333 TF:M05454_1 tf 1 Factor: ZBTB3; motif: KGGTKYCAAC; match class: 1 1 Q8N9U0 119 2.79e-02 1078 3 2 0.667 0.002 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 Q5W0Q7,Q96JC9 119 3.13e-02 5 3 1 0.333 0.200 GO:0030575 BP 1 nuclear body organization 1 Q5W0Q7 119 3.55e-02 1221 3 2 0.667 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q5W0Q7,Q96JC9 119 3.62e-02 57 3 1 0.333 0.018 REAC:75955 rea 1 RNA Polymerase II Transcription Elongation 1 Q96JC9 119 3.62e-02 57 3 1 0.333 0.018 REAC:112382 rea 1 Formation of RNA Pol II elongation complex 1 Q96JC9 119 3.93e-02 7 3 1 0.333 0.143 TF:M03964_1 tf 1 Factor: EBF1; motif: ANTCCCNWGGGAMT; match class: 1 1 Q8N9U0 119 3.95e-02 1291 3 2 0.667 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 Q5W0Q7,Q96JC9 119 4.04e-02 3704 3 3 1.000 0.001 HPA:026010_01 hpa 1 ovary; follicle cells[Uncertain,Low] 1 Q5W0Q7,Q96JC9,Q8N9U0 119 5.00e-02 79 3 1 0.333 0.013 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 Q96JC9 119 5.00e-02 372 3 2 0.667 0.005 MI:hsa-miR-22* mi 1 MI:hsa-miR-22* 1 Q5W0Q7,Q8N9U0 119 5.00e-02 8 3 1 0.333 0.125 GO:0016929 MF 1 SUMO-specific protease activity 1 Q5W0Q7 119 5.00e-02 340 3 2 0.667 0.006 TF:M01856_1 tf 1 Factor: AML3; motif: AACCACAN; match class: 1 1 Q5W0Q7,Q96JC9 119 5.00e-02 8 3 1 0.333 0.125 GO:0016926 BP 1 protein desumoylation 1 Q5W0Q7 119 5.00e-02 340 3 2 0.667 0.006 TF:M01759_1 tf 1 Factor: AML2; motif: AACCRCAA; match class: 1 1 Q5W0Q7,Q96JC9 120 9.11e-03 6 2 1 0.500 0.167 REAC:1433617 rea 1 Regulation of signaling by NODAL 1 P13385 120 1.52e-02 10 2 1 0.500 0.100 REAC:2892247 rea 1 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 1 P13385 120 1.97e-02 13 2 1 0.500 0.077 REAC:1181150 rea 1 Signaling by NODAL 1 P13385 120 3.64e-02 8 2 1 0.500 0.125 TF:M04001_1 tf 1 Factor: GCM1; motif: NATGCGGGTAC; match class: 1 1 Q96G75 120 4.09e-02 9 2 1 0.500 0.111 TF:M02002_1 tf 1 Factor: Evi-1; motif: TATCTTGTC; match class: 1 1 P13385 120 5.00e-02 11 2 1 0.500 0.091 TF:M00080_1 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 1 1 P13385 120 5.00e-02 5 2 1 0.500 0.200 HP:0010644 hp 1 Midnasal stenosis 1 P13385 120 5.00e-02 5 2 1 0.500 0.200 HP:0002708 hp 1 Prominent median palatal raphe 1 P13385 120 5.00e-02 329 2 2 1.000 0.006 MI:hsa-miR-363* mi 1 MI:hsa-miR-363* 1 Q96G75,P13385 120 5.00e-02 5 2 1 0.500 0.200 HP:0010640 hp 1 Abnormality of the nasal cavity 1 P13385 120 5.00e-02 11 2 1 0.500 0.091 TF:M00079_1 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 1 1 P13385 120 5.00e-02 5 2 1 0.500 0.200 HP:0010641 hp 1 Abnormality of the midnasal cavity 1 P13385 120 5.00e-02 5 2 1 0.500 0.200 HP:0009914 hp 1 Cyclopia 1 P13385 120 5.00e-02 33 2 1 0.500 0.030 REAC:452723 rea 1 Transcriptional regulation of pluripotent stem cells 1 P13385 120 5.00e-02 3 2 1 0.500 0.333 GO:0034657 CC 1 GID complex 1 Q96G75 121 9.20e-06 9 4 2 0.500 0.222 GO:0010857 MF 1 calcium-dependent protein kinase activity 1 Q9HBH9,P49137 121 9.20e-06 9 4 2 0.500 0.222 GO:0009931 MF 1 calcium-dependent protein serine/threonine kinase activity 1 Q9HBH9,P49137 121 1.69e-05 12 4 2 0.500 0.167 GO:0070935 BP 1 3'-UTR-mediated mRNA stabilization 1 Q16539,P49137 121 3.59e-05 171 4 3 0.750 0.018 GO:0018105 BP 1 peptidyl-serine phosphorylation 1 Q9HBH9,Q16539,P49137 121 3.91e-05 18 4 2 0.500 0.111 GO:0004683 MF 1 calmodulin-dependent protein kinase activity 1 Q9HBH9,P49137 121 3.99e-05 177 4 3 0.750 0.017 GO:0018209 BP 1 peptidyl-serine modification 1 Q9HBH9,Q16539,P49137 121 4.40e-05 183 4 3 0.750 0.016 GO:0043405 BP 1 regulation of MAP kinase activity 1 Q9BY84,Q16539,P49137 121 4.65e-05 13 4 2 0.500 0.154 REAC:171007 rea 1 p38MAPK events 1 Q16539,P49137 121 5.79e-05 209 4 4 1.000 0.019 KEGG:04010 keg 1 MAPK signaling pathway 1 Q9HBH9,Q9BY84,Q16539,P49137 121 6.46e-05 23 4 2 0.500 0.087 GO:0035924 BP 1 cellular response to vascular endothelial growth factor stimulus 1 Q16539,P49137 121 7.65e-05 25 4 2 0.500 0.080 GO:0048255 BP 1 mRNA stabilization 1 Q16539,P49137 121 8.10e-05 17 4 2 0.500 0.118 REAC:450302 rea 1 activated TAK1 mediates p38 MAPK activation 1 Q16539,P49137 121 8.29e-05 26 4 2 0.500 0.077 GO:0043489 BP 1 RNA stabilization 1 Q16539,P49137 121 1.51e-04 276 4 3 0.750 0.011 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 Q9BY84,Q16539,P49137 121 1.64e-04 24 4 2 0.500 0.083 REAC:198725 rea 1 Nuclear Events (kinase and transcription factor activation) 1 Q16539,P49137 121 2.07e-04 1068 4 4 1.000 0.004 GO:0006468 BP 1 protein phosphorylation 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.22e-04 203 4 3 0.750 0.015 REAC:167044 rea 1 Signalling to RAS 1 Q9BY84,Q16539,P49137 121 2.43e-04 209 4 3 0.750 0.014 REAC:187687 rea 1 Signalling to ERKs 1 Q9BY84,Q16539,P49137 121 2.55e-04 329 4 3 0.750 0.009 GO:0004674 MF 1 protein serine/threonine kinase activity 1 Q9HBH9,Q16539,P49137 121 2.59e-04 30 4 2 0.500 0.067 REAC:450282 rea 1 MAPK targets/ Nuclear events mediated by MAP kinases 1 Q16539,P49137 121 3.18e-04 354 4 3 0.750 0.008 GO:0043408 BP 1 regulation of MAPK cascade 1 Q9BY84,Q16539,P49137 121 4.10e-04 1266 4 4 1.000 0.003 GO:0016310 BP 1 phosphorylation 1 Q9HBH9,Q9BY84,Q16539,P49137 121 4.20e-04 58 4 2 0.500 0.034 GO:0005516 MF 1 calmodulin binding 1 Q9HBH9,P49137 121 4.64e-04 402 4 3 0.750 0.007 GO:0045859 BP 1 regulation of protein kinase activity 1 Q9BY84,Q16539,P49137 121 5.33e-04 272 4 3 0.750 0.011 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q9BY84,Q16539,P49137 121 5.69e-04 278 4 3 0.750 0.011 REAC:194138 rea 1 Signaling by VEGF 1 Q9BY84,Q16539,P49137 121 6.04e-04 439 4 3 0.750 0.007 GO:0043549 BP 1 regulation of kinase activity 1 Q9BY84,Q16539,P49137 121 6.31e-04 71 4 2 0.500 0.028 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 Q16539,P49137 121 7.49e-04 472 4 3 0.750 0.006 GO:0004672 MF 1 protein kinase activity 1 Q9HBH9,Q16539,P49137 121 8.42e-04 82 4 2 0.500 0.024 GO:0000187 BP 1 activation of MAPK activity 1 Q16539,P49137 121 8.82e-04 322 4 3 0.750 0.009 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 Q9BY84,Q16539,P49137 121 8.82e-04 1533 4 4 1.000 0.003 GO:0035556 BP 1 intracellular signal transduction 1 Q9HBH9,Q9BY84,Q16539,P49137 121 8.84e-04 499 4 3 0.750 0.006 GO:0000165 BP 1 MAPK cascade 1 Q9BY84,Q16539,P49137 121 9.00e-04 502 4 3 0.750 0.006 GO:0023014 BP 1 signal transduction by protein phosphorylation 1 Q9BY84,Q16539,P49137 121 9.44e-04 57 4 2 0.500 0.035 REAC:450294 rea 1 MAP kinase activation in TLR cascade 1 Q16539,P49137 121 9.70e-04 88 4 2 0.500 0.023 GO:0032496 BP 1 response to lipopolysaccharide 1 Q16539,P49137 121 9.84e-04 1 4 1 0.250 1.000 GO:0045204 BP 1 MAPK export from nucleus 1 Q9BY84 121 9.84e-04 1 4 1 0.250 1.000 GO:0051525 MF 1 NFAT protein binding 1 Q16539 121 9.84e-04 1 4 1 0.250 1.000 GO:0045208 BP 1 MAPK phosphatase export from nucleus 1 Q9BY84 121 9.84e-04 1 4 1 0.250 1.000 GO:0045209 BP 1 MAPK phosphatase export from nucleus, leptomycin B sensitive 1 Q9BY84 121 1.15e-03 96 4 2 0.500 0.021 GO:0002237 BP 1 response to molecule of bacterial origin 1 Q16539,P49137 121 1.36e-03 577 4 3 0.750 0.005 GO:0051338 BP 1 regulation of transferase activity 1 Q9BY84,Q16539,P49137 121 1.37e-03 578 4 3 0.750 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 Q9HBH9,Q16539,P49137 121 1.61e-03 394 4 3 0.750 0.008 REAC:166520 rea 1 Signalling by NGF 1 Q9BY84,Q16539,P49137 121 1.64e-03 75 4 2 0.500 0.027 REAC:975138 rea 1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1 Q16539,P49137 121 1.64e-03 75 4 2 0.500 0.027 REAC:2559580 rea 1 Oxidative Stress Induced Senescence 1 Q16539,P49137 121 1.68e-03 76 4 2 0.500 0.026 REAC:168142 rea 1 Toll Like Receptor 10 (TLR10) Cascade 1 Q16539,P49137 121 1.68e-03 76 4 2 0.500 0.026 REAC:168181 rea 1 Toll Like Receptor 7/8 (TLR7/8) Cascade 1 Q16539,P49137 121 1.68e-03 76 4 2 0.500 0.026 REAC:168176 rea 1 Toll Like Receptor 5 (TLR5) Cascade 1 Q16539,P49137 121 1.68e-03 76 4 2 0.500 0.026 REAC:975871 rea 1 MyD88 cascade initiated on plasma membrane 1 Q16539,P49137 121 1.68e-03 76 4 2 0.500 0.026 REAC:975155 rea 1 MyD88 dependent cascade initiated on endosome 1 Q16539,P49137 121 1.68e-03 116 4 2 0.500 0.017 GO:0043406 BP 1 positive regulation of MAP kinase activity 1 Q16539,P49137 121 1.76e-03 630 4 3 0.750 0.005 GO:0016301 MF 1 kinase activity 1 Q9HBH9,Q16539,P49137 121 1.86e-03 80 4 2 0.500 0.025 REAC:168138 rea 1 Toll Like Receptor 9 (TLR9) Cascade 1 Q16539,P49137 121 1.88e-03 1851 4 4 1.000 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.89e-03 123 4 2 0.500 0.016 GO:0043488 BP 1 regulation of mRNA stability 1 Q16539,P49137 121 2.00e-03 83 4 2 0.500 0.024 REAC:168188 rea 1 Toll Like Receptor TLR6:TLR2 Cascade 1 Q16539,P49137 121 2.00e-03 83 4 2 0.500 0.024 REAC:181438 rea 1 Toll Like Receptor 2 (TLR2) Cascade 1 Q16539,P49137 121 2.00e-03 83 4 2 0.500 0.024 REAC:168179 rea 1 Toll Like Receptor TLR1:TLR2 Cascade 1 Q16539,P49137 121 2.00e-03 83 4 2 0.500 0.024 REAC:450531 rea 1 Regulation of mRNA stability by proteins that bind AU-rich elements 1 Q16539,P49137 121 2.00e-03 83 4 2 0.500 0.024 REAC:166058 rea 1 MyD88:Mal cascade initiated on plasma membrane 1 Q16539,P49137 121 2.05e-03 128 4 2 0.500 0.016 GO:0043487 BP 1 regulation of RNA stability 1 Q16539,P49137 121 2.19e-03 1923 4 4 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.25e-03 88 4 2 0.500 0.023 REAC:166166 rea 1 MyD88-independent TLR3/TLR4 cascade 1 Q16539,P49137 121 2.25e-03 88 4 2 0.500 0.023 REAC:168164 rea 1 Toll Like Receptor 3 (TLR3) Cascade 1 Q16539,P49137 121 2.25e-03 88 4 2 0.500 0.023 REAC:937061 rea 1 TRIF-mediated TLR3/TLR4 signaling 1 Q16539,P49137 121 2.26e-03 251 4 2 0.500 0.008 TF:M03899_1 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 1 1 Q16539,P49137 121 2.41e-03 700 4 3 0.750 0.004 GO:0001932 BP 1 regulation of protein phosphorylation 1 Q9BY84,Q16539,P49137 121 2.62e-03 720 4 3 0.750 0.004 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9HBH9,Q16539,P49137 121 2.83e-03 9 4 1 0.250 0.111 TF:M06572_0 tf 1 Factor: ZNF597; motif: KGGTAATTGAGA; match class: 0 1 Q16539 121 2.90e-03 100 4 2 0.500 0.020 REAC:166054 rea 1 Activated TLR4 signalling 1 Q16539,P49137 121 2.95e-03 3 4 1 0.250 0.333 GO:2001184 BP 1 positive regulation of interleukin-12 secretion 1 Q16539 121 3.00e-03 155 4 2 0.500 0.013 GO:0032147 BP 1 activation of protein kinase activity 1 Q16539,P49137 121 3.01e-03 755 4 3 0.750 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q9HBH9,Q16539,P49137 121 3.07e-03 760 4 3 0.750 0.004 GO:0042325 BP 1 regulation of phosphorylation 1 Q9BY84,Q16539,P49137 121 3.14e-03 10 4 1 0.250 0.100 TF:M07206_1 tf 1 Factor: E2F1; motif: NGGGCGGGARV; match class: 1 1 Q9BY84 121 3.31e-03 163 4 2 0.500 0.012 GO:0007265 BP 1 Ras protein signal transduction 1 Q16539,P49137 121 3.36e-03 164 4 2 0.500 0.012 GO:0009617 BP 1 response to bacterium 1 Q16539,P49137 121 3.38e-03 108 4 2 0.500 0.019 REAC:166016 rea 1 Toll Like Receptor 4 (TLR4) Cascade 1 Q16539,P49137 121 3.40e-03 165 4 2 0.500 0.012 GO:0071902 BP 1 positive regulation of protein serine/threonine kinase activity 1 Q16539,P49137 121 3.93e-03 4 4 1 0.250 0.250 GO:0072610 BP 1 interleukin-12 secretion 1 Q16539 121 3.93e-03 4 4 1 0.250 0.250 GO:2001182 BP 1 regulation of interleukin-12 secretion 1 Q16539 121 3.99e-03 179 4 2 0.500 0.011 GO:0046777 BP 1 protein autophosphorylation 1 Q9HBH9,P49137 121 4.28e-03 2275 4 4 1.000 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 4.28e-03 2275 4 4 1.000 0.002 GO:0036211 BP 1 protein modification process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 4.39e-03 14 4 1 0.250 0.071 TF:M01043_1 tf 1 Factor: Nkx2-5; motif: TSYCACTTSM; match class: 1 1 Q16539 121 4.67e-03 127 4 2 0.500 0.016 REAC:168898 rea 1 Toll-Like Receptors Cascades 1 Q16539,P49137 121 4.81e-03 885 4 3 0.750 0.003 GO:0019220 BP 1 regulation of phosphate metabolic process 1 Q9BY84,Q16539,P49137 121 4.92e-03 5 4 1 0.250 0.200 GO:1901741 BP 1 positive regulation of myoblast fusion 1 Q16539 121 4.92e-03 5 4 1 0.250 0.200 GO:0090400 BP 1 stress-induced premature senescence 1 Q16539 121 4.93e-03 3374 4 4 1.000 0.001 TF:M03804_1 tf 1 Factor: Tal-1; motif: CAGATGG; match class: 1 1 Q9HBH9,Q9BY84,Q16539,P49137 121 5.01e-03 897 4 3 0.750 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 Q9BY84,Q16539,P49137 121 5.46e-03 2417 4 4 1.000 0.002 GO:0043412 BP 1 macromolecule modification 1 Q9HBH9,Q9BY84,Q16539,P49137 121 5.51e-03 138 4 2 0.500 0.014 REAC:2559583 rea 1 Cellular Senescence 1 Q16539,P49137 121 5.90e-03 6 4 1 0.250 0.167 GO:1901739 BP 1 regulation of myoblast fusion 1 Q16539 121 6.23e-03 224 4 2 0.500 0.009 GO:0006954 BP 1 inflammatory response 1 Q16539,P49137 121 6.25e-03 967 4 3 0.750 0.003 GO:0031399 BP 1 regulation of protein modification process 1 Q9BY84,Q16539,P49137 121 6.27e-03 3582 4 4 1.000 0.001 TF:M01587_0 tf 1 Factor: FPM315; motif: SRGGGAGGAGGN; match class: 0 1 Q9HBH9,Q9BY84,Q16539,P49137 121 6.54e-03 2529 4 4 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q9HBH9,Q9BY84,Q16539,P49137 121 6.79e-03 234 4 2 0.500 0.009 GO:0043410 BP 1 positive regulation of MAPK cascade 1 Q16539,P49137 121 6.88e-03 7 4 1 0.250 0.143 GO:0045663 BP 1 positive regulation of myoblast differentiation 1 Q16539 121 6.88e-03 7 4 1 0.250 0.143 GO:0060143 BP 1 positive regulation of syncytium formation by plasma membrane fusion 1 Q16539 121 7.45e-03 1027 4 3 0.750 0.003 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q9BY84,Q16539,P49137 121 7.86e-03 252 4 2 0.500 0.008 GO:0045860 BP 1 positive regulation of protein kinase activity 1 Q16539,P49137 121 7.86e-03 8 4 1 0.250 0.125 GO:0060142 BP 1 regulation of syncytium formation by plasma membrane fusion 1 Q16539 121 7.86e-03 8 4 1 0.250 0.125 GO:0044351 BP 1 macropinocytosis 1 P49137 121 7.86e-03 8 4 1 0.250 0.125 GO:0071243 BP 1 cellular response to arsenic-containing substance 1 Q9HBH9 121 8.43e-03 1071 4 3 0.750 0.003 GO:0050790 BP 1 regulation of catalytic activity 1 Q9BY84,Q16539,P49137 121 8.55e-03 263 4 2 0.500 0.008 GO:0030097 BP 1 hemopoiesis 1 Q9HBH9,Q16539 121 8.81e-03 267 4 2 0.500 0.007 GO:0007264 BP 1 small GTPase mediated signal transduction 1 Q16539,P49137 121 8.84e-03 9 4 1 0.250 0.111 GO:0010831 BP 1 positive regulation of myotube differentiation 1 Q16539 121 9.20e-03 273 4 2 0.500 0.007 GO:0033674 BP 1 positive regulation of kinase activity 1 Q16539,P49137 121 9.27e-03 274 4 2 0.500 0.007 GO:0048534 BP 1 hematopoietic or lymphoid organ development 1 Q9HBH9,Q16539 121 9.48e-03 458 4 2 0.500 0.004 MI:hsa-miR-24 mi 1 MI:hsa-miR-24 1 Q9HBH9,Q9BY84 121 9.82e-03 10 4 1 0.250 0.100 GO:0006691 BP 1 leukotriene metabolic process 1 P49137 121 9.82e-03 10 4 1 0.250 0.100 GO:1900015 BP 1 regulation of cytokine production involved in inflammatory response 1 Q16539 121 9.82e-03 10 4 1 0.250 0.100 GO:0002534 BP 1 cytokine production involved in inflammatory response 1 Q16539 121 9.88e-03 283 4 2 0.500 0.007 GO:0001817 BP 1 regulation of cytokine production 1 Q16539,P49137 121 1.01e-02 7 4 1 0.250 0.143 REAC:199920 rea 1 CREB phosphorylation 1 P49137 121 1.04e-02 1818 4 3 0.750 0.002 TF:M07062_0 tf 1 Factor: RREB1; motif: GRSDSGGGKTGGGKGG; match class: 0 1 Q9HBH9,Q9BY84,Q16539 121 1.06e-02 293 4 2 0.500 0.007 GO:0033993 BP 1 response to lipid 1 Q16539,P49137 121 1.06e-02 293 4 2 0.500 0.007 GO:0002520 BP 1 immune system development 1 Q9HBH9,Q16539 121 1.08e-02 1165 4 3 0.750 0.003 GO:0002376 BP 1 immune system process 1 Q9HBH9,Q16539,P49137 121 1.08e-02 11 4 1 0.250 0.091 GO:0004708 MF 1 MAP kinase kinase activity 1 Q16539 121 1.08e-02 11 4 1 0.250 0.091 GO:0007520 BP 1 myoblast fusion 1 Q16539 121 1.08e-02 11 4 1 0.250 0.091 GO:0046685 BP 1 response to arsenic-containing substance 1 Q9HBH9 121 1.14e-02 305 4 2 0.500 0.007 GO:0043207 BP 1 response to external biotic stimulus 1 Q16539,P49137 121 1.14e-02 305 4 2 0.500 0.007 GO:0051707 BP 1 response to other organism 1 Q16539,P49137 121 1.14e-02 305 4 2 0.500 0.007 GO:0001816 BP 1 cytokine production 1 Q16539,P49137 121 1.18e-02 12 4 1 0.250 0.083 GO:0004707 MF 1 MAP kinase activity 1 Q16539 121 1.18e-02 2931 4 4 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.22e-02 39 4 1 0.250 0.026 TF:M03905_0 tf 1 Factor: GLIS3; motif: GACCCCCCACGAAG; match class: 0 1 Q16539 121 1.23e-02 316 4 2 0.500 0.006 GO:0071363 BP 1 cellular response to growth factor stimulus 1 Q16539,P49137 121 1.24e-02 318 4 2 0.500 0.006 GO:0010608 BP 1 posttranscriptional regulation of gene expression 1 Q16539,P49137 121 1.28e-02 2990 4 4 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.29e-02 324 4 2 0.500 0.006 GO:0009607 BP 1 response to biotic stimulus 1 Q16539,P49137 121 1.29e-02 9 4 1 0.250 0.111 REAC:2151209 rea 1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 Q16539 121 1.29e-02 9 4 1 0.250 0.111 REAC:2142691 rea 1 Synthesis of Leukotrienes (LT) and Eoxins (EX) 1 P49137 121 1.30e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.30e-02 326 4 2 0.500 0.006 GO:0070848 BP 1 response to growth factor 1 Q16539,P49137 121 1.35e-02 54 4 2 0.500 0.037 KEGG:04370 keg 1 VEGF signaling pathway 1 Q16539,P49137 121 1.37e-02 14 4 1 0.250 0.071 GO:0000768 BP 1 syncytium formation by plasma membrane fusion 1 Q16539 121 1.37e-02 14 4 1 0.250 0.071 GO:0006949 BP 1 syncytium formation 1 Q16539 121 1.44e-02 10 4 1 0.250 0.100 REAC:450341 rea 1 Activation of the AP-1 family of transcription factors 1 Q16539 121 1.47e-02 47 4 1 0.250 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 P49137 121 1.47e-02 15 4 1 0.250 0.067 GO:0032735 BP 1 positive regulation of interleukin-12 production 1 Q16539 121 1.47e-02 15 4 1 0.250 0.067 GO:0045648 BP 1 positive regulation of erythrocyte differentiation 1 Q16539 121 1.57e-02 16 4 1 0.250 0.062 GO:0006907 BP 1 pinocytosis 1 P49137 121 1.57e-02 16 4 1 0.250 0.062 GO:0051155 BP 1 positive regulation of striated muscle cell differentiation 1 Q16539 121 1.57e-02 16 4 1 0.250 0.062 GO:0045661 BP 1 regulation of myoblast differentiation 1 Q16539 121 1.58e-02 11 4 1 0.250 0.091 REAC:376172 rea 1 DSCAM interactions 1 Q16539 121 1.61e-02 3168 4 4 1.000 0.001 GO:0044428 CC 1 nuclear part 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.63e-02 1342 4 3 0.750 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 Q9BY84,Q16539,P49137 121 1.65e-02 3185 4 4 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.67e-02 17 4 1 0.250 0.059 GO:0000188 BP 1 inactivation of MAPK activity 1 Q9BY84 121 1.70e-02 703 4 2 0.500 0.003 TF:M04048_0 tf 1 Factor: MYBL2; motif: NNAACCGTTAN; match class: 0 1 Q9BY84,Q16539 121 1.77e-02 18 4 1 0.250 0.056 GO:0043536 BP 1 positive regulation of blood vessel endothelial cell migration 1 Q16539 121 1.79e-02 383 4 2 0.500 0.005 GO:0031347 BP 1 regulation of defense response 1 Q16539,P49137 121 1.80e-02 1388 4 3 0.750 0.002 GO:0065009 BP 1 regulation of molecular function 1 Q9BY84,Q16539,P49137 121 1.81e-02 727 4 2 0.500 0.003 TF:M04007_0 tf 1 Factor: HOMEZ; motif: AAAACGATTAWA; match class: 0 1 Q9BY84,Q16539 121 1.81e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.82e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.84e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 Q9HBH9,Q9BY84,Q16539,P49137 121 1.85e-02 390 4 2 0.500 0.005 GO:0051347 BP 1 positive regulation of transferase activity 1 Q16539,P49137 121 1.86e-02 19 4 1 0.250 0.053 GO:0098586 BP 1 cellular response to virus 1 Q16539 121 1.86e-02 19 4 1 0.250 0.053 GO:0038066 BP 1 p38MAPK cascade 1 Q16539 121 1.90e-02 1416 4 3 0.750 0.002 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q9HBH9,Q16539,P49137 121 1.93e-02 1423 4 3 0.750 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q9HBH9,Q16539,P49137 121 2.01e-02 1442 4 3 0.750 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 Q9BY84,Q16539,P49137 121 2.01e-02 2290 4 3 0.750 0.001 TF:M01217_0 tf 1 Factor: NUR77; motif: NTGACCTTBN; match class: 0 1 Q9HBH9,Q16539,P49137 121 2.05e-02 938 4 3 0.750 0.003 REAC:168249 rea 1 Innate Immune System 1 Q9BY84,Q16539,P49137 121 2.16e-02 22 4 1 0.250 0.045 GO:0010830 BP 1 regulation of myotube differentiation 1 Q16539 121 2.16e-02 22 4 1 0.250 0.045 GO:0002532 BP 1 production of molecular mediator involved in inflammatory response 1 Q16539 121 2.24e-02 2379 4 3 0.750 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q9HBH9,Q9BY84,Q16539 121 2.24e-02 72 4 1 0.250 0.014 TF:M06363_0 tf 1 Factor: ZNF730; motif: NNGGTGGACCGC; match class: 0 1 Q16539 121 2.26e-02 23 4 1 0.250 0.043 GO:0004712 MF 1 protein serine/threonine/tyrosine kinase activity 1 Q16539 121 2.26e-02 432 4 2 0.500 0.005 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q16539,P49137 121 2.29e-02 16 4 1 0.250 0.062 REAC:450513 rea 1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1 P49137 121 2.29e-02 16 4 1 0.250 0.062 REAC:432142 rea 1 Platelet sensitization by LDL 1 Q16539 121 2.34e-02 75 4 1 0.250 0.013 TF:M06020_0 tf 1 Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 0 1 Q9HBH9 121 2.35e-02 4986 4 4 1.000 0.001 TF:M02108_0 tf 1 Factor: Nkx2.5; motif: NNCACTTGNRN; match class: 0 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.35e-02 24 4 1 0.250 0.042 GO:0032655 BP 1 regulation of interleukin-12 production 1 Q16539 121 2.35e-02 24 4 1 0.250 0.042 GO:0045646 BP 1 regulation of erythrocyte differentiation 1 Q16539 121 2.35e-02 24 4 1 0.250 0.042 GO:0032615 BP 1 interleukin-12 production 1 Q16539 121 2.40e-02 77 4 1 0.250 0.013 TF:M06650_0 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 0 1 P49137 121 2.44e-02 17 4 1 0.250 0.059 REAC:450604 rea 1 KSRP (KHSRP) binds and destabilizes mRNA 1 Q16539 121 2.44e-02 17 4 1 0.250 0.059 REAC:450385 rea 1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1 P49137 121 2.55e-02 459 4 2 0.500 0.004 GO:0001934 BP 1 positive regulation of protein phosphorylation 1 Q16539,P49137 121 2.57e-02 3561 4 4 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.57e-02 3561 4 4 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.57e-02 3561 4 4 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 Q9HBH9,Q9BY84,Q16539,P49137 121 2.58e-02 1573 4 3 0.750 0.002 GO:0009966 BP 1 regulation of signal transduction 1 Q9BY84,Q16539,P49137 121 2.58e-02 18 4 1 0.250 0.056 REAC:112409 rea 1 RAF-independent MAPK1/3 activation 1 Q9BY84 121 2.66e-02 889 4 2 0.500 0.002 TF:M04044_0 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 0 1 Q9BY84,Q16539 121 2.74e-02 28 4 1 0.250 0.036 GO:0030316 BP 1 osteoclast differentiation 1 Q16539 121 2.81e-02 483 4 2 0.500 0.004 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 Q16539,P49137 121 2.83e-02 484 4 2 0.500 0.004 GO:0042327 BP 1 positive regulation of phosphorylation 1 Q16539,P49137 121 2.83e-02 91 4 1 0.250 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 Q9BY84 121 2.84e-02 29 4 1 0.250 0.034 GO:0045445 BP 1 myoblast differentiation 1 Q16539 121 2.84e-02 29 4 1 0.250 0.034 GO:0031281 BP 1 positive regulation of cyclase activity 1 Q16539 121 2.84e-02 29 4 1 0.250 0.034 GO:0031572 BP 1 G2 DNA damage checkpoint 1 P49137 121 2.87e-02 20 4 1 0.250 0.050 REAC:418592 rea 1 ADP signalling through P2Y purinoceptor 1 1 Q16539 121 3.00e-02 499 4 2 0.500 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 Q16539,P49137 121 3.01e-02 21 4 1 0.250 0.048 REAC:198753 rea 1 ERK/MAPK targets 1 Q16539 121 3.15e-02 22 4 1 0.250 0.045 REAC:375170 rea 1 CDO in myogenesis 1 Q16539 121 3.15e-02 22 4 1 0.250 0.045 REAC:525793 rea 1 Myogenesis 1 Q16539 121 3.18e-02 1691 4 3 0.750 0.002 GO:0010646 BP 1 regulation of cell communication 1 Q9BY84,Q16539,P49137 121 3.18e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 Q9HBH9,Q9BY84,Q16539,P49137 121 3.23e-02 33 4 1 0.250 0.030 GO:0090398 BP 1 cellular senescence 1 Q16539 121 3.24e-02 519 4 2 0.500 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 Q16539,P49137 121 3.31e-02 1715 4 3 0.750 0.002 GO:0016740 MF 1 transferase activity 1 Q9HBH9,Q16539,P49137 121 3.31e-02 5431 4 4 1.000 0.001 TF:M01865_0 tf 1 Factor: BTEB3; motif: BNRNGGGAGGNGT; match class: 0 1 Q9HBH9,Q9BY84,Q16539,P49137 121 3.33e-02 34 4 1 0.250 0.029 GO:0051153 BP 1 regulation of striated muscle cell differentiation 1 Q16539 121 3.33e-02 34 4 1 0.250 0.029 GO:0071479 BP 1 cellular response to ionizing radiation 1 Q16539 121 3.36e-02 529 4 2 0.500 0.004 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 Q16539,P49137 121 3.36e-02 529 4 2 0.500 0.004 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 Q16539,P49137 121 3.38e-02 1728 4 3 0.750 0.002 GO:0023051 BP 1 regulation of signaling 1 Q9BY84,Q16539,P49137 121 3.52e-02 1031 4 2 0.500 0.002 TF:M00260_0 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 0 1 Q9BY84,P49137 121 3.62e-02 37 4 1 0.250 0.027 GO:0043535 BP 1 regulation of blood vessel endothelial cell migration 1 Q16539 121 3.62e-02 37 4 1 0.250 0.027 GO:0051149 BP 1 positive regulation of muscle cell differentiation 1 Q16539 121 3.62e-02 37 4 1 0.250 0.027 GO:0014902 BP 1 myotube differentiation 1 Q16539 121 3.66e-02 118 4 1 0.250 0.008 TF:M00054_1 tf 1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 1 Q9HBH9 121 3.69e-02 5578 4 4 1.000 0.001 TF:M01872_0 tf 1 Factor: DBP; motif: TTWTGYAA; match class: 0 1 Q9HBH9,Q9BY84,Q16539,P49137 121 3.72e-02 120 4 1 0.250 0.008 TF:M06463_0 tf 1 Factor: ZNF595; motif: NGKGGCGGCMGM; match class: 0 1 P49137 121 3.72e-02 38 4 1 0.250 0.026 GO:0031279 BP 1 regulation of cyclase activity 1 Q16539 121 3.72e-02 38 4 1 0.250 0.026 GO:0045639 BP 1 positive regulation of myeloid cell differentiation 1 Q16539 121 3.82e-02 39 4 1 0.250 0.026 GO:0006611 BP 1 protein export from nucleus 1 Q9BY84 121 3.86e-02 27 4 1 0.250 0.037 REAC:392518 rea 1 Signal amplification 1 Q16539 121 3.91e-02 5662 4 4 1.000 0.001 TF:M00428_0 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 0 1 Q9HBH9,Q9BY84,Q16539,P49137 121 3.91e-02 40 4 1 0.250 0.025 GO:0050715 BP 1 positive regulation of cytokine secretion 1 Q16539 121 3.96e-02 128 4 1 0.250 0.008 TF:M04411_1 tf 1 Factor: NKX2-3; motif: NCCACTTRAN; match class: 1 1 Q16539 121 3.97e-02 378 4 2 0.500 0.005 REAC:2262752 rea 1 Cellular responses to stress 1 Q16539,P49137 121 4.09e-02 586 4 2 0.500 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 Q16539,P49137 121 4.11e-02 42 4 1 0.250 0.024 GO:0032675 BP 1 regulation of interleukin-6 production 1 P49137 121 4.18e-02 4019 4 4 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 Q9HBH9,Q9BY84,Q16539,P49137 121 4.18e-02 592 4 2 0.500 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q16539,P49137 121 4.19e-02 593 4 2 0.500 0.003 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q16539,P49137 121 4.21e-02 43 4 1 0.250 0.023 GO:0030218 BP 1 erythrocyte differentiation 1 Q16539 121 4.29e-02 30 4 1 0.250 0.033 REAC:168638 rea 1 NOD1/2 Signaling Pathway 1 Q16539 121 4.30e-02 44 4 1 0.250 0.023 GO:0010595 BP 1 positive regulation of endothelial cell migration 1 Q16539 121 4.30e-02 44 4 1 0.250 0.023 GO:0032635 BP 1 interleukin-6 production 1 P49137 121 4.32e-02 1882 4 3 0.750 0.002 GO:0042221 BP 1 response to chemical 1 Q9HBH9,Q16539,P49137 121 4.40e-02 45 4 1 0.250 0.022 GO:0043407 BP 1 negative regulation of MAP kinase activity 1 Q9BY84 121 4.40e-02 45 4 1 0.250 0.022 GO:0032680 BP 1 regulation of tumor necrosis factor production 1 P49137 121 4.40e-02 45 4 1 0.250 0.022 GO:2000379 BP 1 positive regulation of reactive oxygen species metabolic process 1 Q16539 121 4.45e-02 144 4 1 0.250 0.007 TF:M07362_1 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 1 1 Q9BY84 121 4.50e-02 46 4 1 0.250 0.022 GO:0034101 BP 1 erythrocyte homeostasis 1 Q16539 121 4.50e-02 46 4 1 0.250 0.022 GO:0032640 BP 1 tumor necrosis factor production 1 P49137 121 4.51e-02 3049 4 3 0.750 0.001 TF:M01219_0 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 0 1 Q9HBH9,Q9BY84,P49137 121 4.52e-02 3052 4 3 0.750 0.001 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q9HBH9,Q9BY84,P49137 121 4.52e-02 3052 4 3 0.750 0.001 TF:M07284_1 tf 1 Factor: Erg; motif: MCAGGAAA; match class: 1 1 Q9HBH9,Q16539,P49137 121 4.57e-02 148 4 1 0.250 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 Q9HBH9 121 4.57e-02 32 4 1 0.250 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 P49137 121 4.59e-02 47 4 1 0.250 0.021 GO:1903555 BP 1 regulation of tumor necrosis factor superfamily cytokine production 1 P49137 121 4.59e-02 47 4 1 0.250 0.021 GO:0043534 BP 1 blood vessel endothelial cell migration 1 Q16539 121 4.66e-02 151 4 1 0.250 0.007 TF:M04619_1 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 1 Q16539 121 4.79e-02 49 4 1 0.250 0.020 GO:0071706 BP 1 tumor necrosis factor superfamily cytokine production 1 P49137 121 4.89e-02 50 4 1 0.250 0.020 GO:0006690 BP 1 icosanoid metabolic process 1 P49137 121 4.89e-02 50 4 1 0.250 0.020 GO:0007569 BP 1 cell aging 1 Q16539 121 4.89e-02 50 4 1 0.250 0.020 GO:1901568 BP 1 fatty acid derivative metabolic process 1 P49137 121 4.96e-02 6006 4 4 1.000 0.001 TF:M00189_1 tf 1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 1 Q9HBH9,Q9BY84,Q16539,P49137 121 5.00e-02 35 4 1 0.250 0.029 REAC:5675221 rea 1 Negative regulation of MAPK pathway 1 Q9BY84 121 5.00e-02 650 4 2 0.500 0.003 GO:0031401 BP 1 positive regulation of protein modification process 1 Q16539,P49137 121 5.00e-02 104 4 2 0.500 0.019 KEGG:04722 keg 1 Neurotrophin signaling pathway 1 Q16539,P49137 122 1.13e-03 429 2 2 1.000 0.005 TF:M00797_0 tf 1 Factor: HIF1; motif: GNNKACGTGCGGNN; match class: 0 1 Q8IUC4,O43521 122 1.78e-03 473 2 2 1.000 0.004 MI:hsa-miR-532-5p mi 1 MI:hsa-miR-532-5p 1 Q8IUC4,O43521 122 1.96e-03 3 2 1 0.500 0.333 REAC:111446 rea 1 Activation of BIM and translocation to mitochondria 1 O43521 122 3.92e-03 6 2 1 0.500 0.167 REAC:111453 rea 1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1 O43521 122 4.29e-03 3 2 1 0.500 0.333 GO:2000271 BP 1 positive regulation of fibroblast apoptotic process 1 O43521 122 5.22e-03 8 2 1 0.500 0.125 REAC:5666185 rea 1 RHO GTPases Activate Rhotekin and Rhophilins 1 Q8IUC4 122 5.34e-03 34 2 1 0.500 0.029 TF:M00407_0 tf 1 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN; match class: 0 1 Q8IUC4 122 5.61e-03 954 2 2 1.000 0.002 TF:M02378_0 tf 1 Factor: HIF1A:ARNT; motif: VNACGTGN; match class: 0 1 Q8IUC4,O43521 122 7.15e-03 5 2 1 0.500 0.200 GO:1902237 BP 1 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1 O43521 122 7.15e-03 5 2 1 0.500 0.200 GO:0032464 BP 1 positive regulation of protein homooligomerization 1 O43521 122 7.15e-03 5 2 1 0.500 0.200 GO:2000269 BP 1 regulation of fibroblast apoptotic process 1 O43521 122 8.58e-03 6 2 1 0.500 0.167 GO:0044346 BP 1 fibroblast apoptotic process 1 O43521 122 1.00e-02 7 2 1 0.500 0.143 GO:1903896 BP 1 positive regulation of IRE1-mediated unfolded protein response 1 O43521 122 1.03e-02 66 2 1 0.500 0.015 TF:M06117_1 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 1 1 O43521 122 1.18e-02 75 2 1 0.500 0.013 TF:M06507_0 tf 1 Factor: ZFP90; motif: NGGGASTTTAKA; match class: 0 1 Q8IUC4 122 1.39e-02 1499 2 2 1.000 0.001 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 Q8IUC4,O43521 122 1.43e-02 10 2 1 0.500 0.100 GO:1900103 BP 1 positive regulation of endoplasmic reticulum unfolded protein response 1 O43521 122 1.43e-02 10 2 1 0.500 0.100 GO:1903894 BP 1 regulation of IRE1-mediated unfolded protein response 1 O43521 122 1.43e-02 10 2 1 0.500 0.100 GO:0032462 BP 1 regulation of protein homooligomerization 1 O43521 122 1.60e-02 102 2 1 0.500 0.010 TF:M06385_0 tf 1 Factor: EZI; motif: NGGGCCTGGGGA; match class: 0 1 O43521 122 1.76e-02 27 2 1 0.500 0.037 REAC:114452 rea 1 Activation of BH3-only proteins 1 O43521 122 1.77e-02 113 2 1 0.500 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 O43521 122 1.80e-02 1707 2 2 1.000 0.001 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q8IUC4,O43521 122 1.94e-02 1775 2 2 1.000 0.001 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 Q8IUC4,O43521 122 1.95e-02 1776 2 2 1.000 0.001 TF:M01843_1 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 1 1 Q8IUC4,O43521 122 2.00e-02 14 2 1 0.500 0.071 GO:0032461 BP 1 positive regulation of protein oligomerization 1 O43521 122 2.06e-02 30 2 1 0.500 0.033 KEGG:04215 keg 1 Apoptosis - multiple species 1 O43521 122 2.20e-02 141 2 1 0.500 0.007 TF:M01301_0 tf 1 Factor: MEF-2A; motif: RGYTATTTTTAR; match class: 0 1 Q8IUC4 122 2.29e-02 16 2 1 0.500 0.062 GO:1902235 BP 1 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1 O43521 122 2.29e-02 16 2 1 0.500 0.062 GO:1900101 BP 1 regulation of endoplasmic reticulum unfolded protein response 1 O43521 122 2.34e-02 150 2 1 0.500 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 O43521 122 2.36e-02 1956 2 2 1.000 0.001 TF:M07235_0 tf 1 Factor: ZEB1; motif: NCWCACCTG; match class: 0 1 Q8IUC4,O43521 122 2.43e-02 17 2 1 0.500 0.059 GO:0090200 BP 1 positive regulation of release of cytochrome c from mitochondria 1 O43521 122 2.44e-02 1989 2 2 1.000 0.001 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q8IUC4,O43521 122 2.48e-02 159 2 1 0.500 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 O43521 122 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 O43521 122 2.54e-02 39 2 1 0.500 0.026 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 O43521 122 2.96e-02 190 2 1 0.500 0.005 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 O43521 122 2.98e-02 2199 2 2 1.000 0.001 TF:M07394_0 tf 1 Factor: slug; motif: CACCTGNNN; match class: 0 1 Q8IUC4,O43521 122 2.99e-02 46 2 1 0.500 0.022 REAC:193648 rea 1 NRAGE signals death through JNK 1 O43521 122 3.03e-02 2216 2 2 1.000 0.001 TF:M00740_0 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 0 1 Q8IUC4,O43521 122 3.14e-02 22 2 1 0.500 0.045 GO:0032459 BP 1 regulation of protein oligomerization 1 O43521 122 3.27e-02 210 2 1 0.500 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 O43521 122 3.34e-02 2326 2 2 1.000 0.001 TF:M04169_0 tf 1 Factor: FIGLA; motif: NMCACCTGKN; match class: 0 1 Q8IUC4,O43521 122 3.34e-02 2328 2 2 1.000 0.001 TF:M03834_0 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 0 1 Q8IUC4,O43521 122 3.49e-02 2379 2 2 1.000 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q8IUC4,O43521 122 3.55e-02 228 2 1 0.500 0.004 TF:M06114_0 tf 1 Factor: ZNF432; motif: NCRTCATMGCGM; match class: 0 1 O43521 122 3.57e-02 25 2 1 0.500 0.040 GO:1900739 BP 1 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521 122 3.57e-02 25 2 1 0.500 0.040 GO:1900740 BP 1 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521 122 3.63e-02 205 2 1 0.500 0.005 MI:hsa-miR-340* mi 1 MI:hsa-miR-340* 1 O43521 122 3.84e-02 59 2 1 0.500 0.017 REAC:204998 rea 1 Cell death signalling via NRAGE, NRIF and NADE 1 O43521 122 3.86e-02 27 2 1 0.500 0.037 GO:0090199 BP 1 regulation of release of cytochrome c from mitochondria 1 O43521 122 3.86e-02 27 2 1 0.500 0.037 GO:0051204 BP 1 protein insertion into mitochondrial membrane 1 O43521 122 3.86e-02 27 2 1 0.500 0.037 GO:0001844 BP 1 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521 122 3.94e-02 253 2 1 0.500 0.004 TF:M04017_0 tf 1 Factor: IRF5; motif: NACCGAAACYA; match class: 0 1 O43521 122 4.00e-02 257 2 1 0.500 0.004 TF:M04203_1 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 1 1 O43521 122 4.32e-02 278 2 1 0.500 0.004 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 O43521 122 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 O43521 122 4.43e-02 31 2 1 0.500 0.032 GO:2001244 BP 1 positive regulation of intrinsic apoptotic signaling pathway 1 O43521 122 4.47e-02 288 2 1 0.500 0.003 TF:M07394_1 tf 1 Factor: slug; motif: CACCTGNNN; match class: 1 1 Q8IUC4 122 4.54e-02 292 2 1 0.500 0.003 TF:M04106_0 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 0 1 O43521 122 4.57e-02 32 2 1 0.500 0.031 GO:1901030 BP 1 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 O43521 122 4.57e-02 32 2 1 0.500 0.031 GO:0070059 BP 1 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1 O43521 122 4.71e-02 33 2 1 0.500 0.030 GO:0051205 BP 1 protein insertion into membrane 1 O43521 122 4.80e-02 309 2 1 0.500 0.003 TF:M00919_1 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 1 1 O43521 122 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 O43521 122 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 O43521 122 5.00e-02 73 2 1 0.500 0.014 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 O43521 122 5.00e-02 35 2 1 0.500 0.029 GO:0001836 BP 1 release of cytochrome c from mitochondria 1 O43521 123 1.37e-05 15 2 2 1.000 0.133 GO:0031146 BP 1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1 Q13616,Q9H469 123 9.17e-05 38 2 2 1.000 0.053 GO:0019005 CC 1 SCF ubiquitin ligase complex 1 Q13616,Q9H469 123 9.43e-04 6 2 1 0.500 0.167 TF:M06702_0 tf 1 Factor: ZNF226; motif: CAGACGARGACC; match class: 0 1 Q9H469 123 1.22e-03 137 2 2 1.000 0.015 GO:0031461 CC 1 cullin-RING ubiquitin ligase complex 1 Q13616,Q9H469 123 1.54e-03 154 2 2 1.000 0.013 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 Q13616,Q9H469 123 1.68e-03 161 2 2 1.000 0.012 GO:0044839 BP 1 cell cycle G2/M phase transition 1 Q13616,Q9H469 123 1.70e-03 5 2 1 0.500 0.200 REAC:2644607 rea 1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 1 Q13616 123 1.70e-03 5 2 1 0.500 0.200 REAC:2644605 rea 1 FBXW7 Mutants and NOTCH1 in Cancer 1 Q13616 123 1.74e-03 272 2 2 1.000 0.007 REAC:983168 rea 1 Antigen processing: Ubiquitination & Proteasome degradation 1 Q13616,Q9H469 123 2.36e-03 15 2 1 0.500 0.067 TF:M06048_0 tf 1 Factor: ZNF208; motif: NGNKGAAGTTGC; match class: 0 1 Q9H469 123 2.44e-03 322 2 2 1.000 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q13616,Q9H469 123 3.03e-03 701 2 2 1.000 0.003 TF:M05938_0 tf 1 Factor: ZNF714; motif: NSGKTGGGCCGM; match class: 0 1 Q13616,Q9H469 123 3.32e-03 226 2 2 1.000 0.009 GO:0000151 CC 1 ubiquitin ligase complex 1 Q13616,Q9H469 123 3.74e-03 11 2 1 0.500 0.091 REAC:1170546 rea 1 Prolactin receptor signaling 1 Q13616 123 4.02e-03 2 2 1 0.500 0.500 CORUM:2714 cor 1 Ubiquitin E3 ligase (CHEK1, CUL1) 1 Q13616 123 4.42e-03 13 2 1 0.500 0.077 REAC:5684264 rea 1 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1 Q13616 123 4.51e-03 3 2 1 0.500 0.333 GO:1990452 CC 1 Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 Q13616 123 5.74e-03 965 2 2 1.000 0.002 TF:M04631_0 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 0 1 Q13616,Q9H469 123 5.93e-03 302 2 2 1.000 0.007 GO:0004842 MF 1 ubiquitin-protein transferase activity 1 Q13616,Q9H469 123 6.03e-03 3 2 1 0.500 0.333 CORUM:2881 cor 1 Ubiquitin E3 ligase (CUL1, RBX1, SKP1A) 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:219 cor 1 CAND1-CUL1-RBX1 complex 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:2170 cor 1 Ubiquitin E3 ligase (CDC34, CUL1, RBX1) 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:615 cor 1 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:4072 cor 1 Heterotrimeric SKP1-CUL1-ROC1 complex 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:226 cor 1 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:227 cor 1 Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) 1 Q13616 123 6.03e-03 3 2 1 0.500 0.333 CORUM:390 cor 1 Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) 1 Q13616 123 6.13e-03 307 2 2 1.000 0.007 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 Q13616,Q9H469 123 6.58e-03 318 2 2 1.000 0.006 GO:0019787 MF 1 ubiquitin-like protein transferase activity 1 Q13616,Q9H469 123 6.87e-03 325 2 2 1.000 0.006 GO:0010498 BP 1 proteasomal protein catabolic process 1 Q13616,Q9H469 123 7.22e-03 46 2 1 0.500 0.022 TF:M06596_0 tf 1 Factor: ZNF486; motif: GKGCCAACGC; match class: 0 1 Q9H469 123 8.04e-03 4 2 1 0.500 0.250 CORUM:1260 cor 1 Neddylin ligase (FBXO11, SKP1, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2724 cor 1 Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:1052 cor 1 Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2725 cor 1 Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2773 cor 1 Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2772 cor 1 Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2192 cor 1 Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:80 cor 1 Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:1253 cor 1 Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:729 cor 1 Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:2191 cor 1 Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:1051 cor 1 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) 1 Q13616 123 8.04e-03 4 2 1 0.500 0.250 CORUM:1215 cor 1 Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) 1 Q13616 123 8.87e-03 614 2 2 1.000 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 Q13616,Q9H469 123 9.18e-03 27 2 1 0.500 0.037 REAC:1251985 rea 1 Nuclear signaling by ERBB4 1 Q13616 123 9.41e-03 60 2 1 0.500 0.017 TF:M06446_0 tf 1 Factor: ZNF525; motif: NSTTAAAYCAGA; match class: 0 1 Q9H469 123 1.00e-02 5 2 1 0.500 0.200 CORUM:3036 cor 1 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) 1 Q13616 123 1.00e-02 5 2 1 0.500 0.200 CORUM:2189 cor 1 Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) 1 Q13616 123 1.00e-02 5 2 1 0.500 0.200 CORUM:2187 cor 1 Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) 1 Q13616 123 1.00e-02 5 2 1 0.500 0.200 CORUM:2188 cor 1 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) 1 Q13616 123 1.06e-02 404 2 2 1.000 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q13616,Q9H469 123 1.07e-02 68 2 1 0.500 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q9H469 123 1.08e-02 408 2 2 1.000 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q13616,Q9H469 123 1.10e-02 411 2 2 1.000 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q13616,Q9H469 123 1.11e-02 71 2 1 0.500 0.014 TF:M05497_0 tf 1 Factor: TBX20; motif: AGGTGTKAAAN; match class: 0 1 Q13616 123 1.12e-02 26 2 1 0.500 0.038 KEGG:04710 keg 1 Circadian rhythm 1 Q13616 123 1.13e-02 416 2 2 1.000 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q13616,Q9H469 123 1.18e-02 75 2 1 0.500 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 Q13616 123 1.18e-02 425 2 2 1.000 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q13616,Q9H469 123 1.19e-02 35 2 1 0.500 0.029 REAC:446652 rea 1 Interleukin-1 signaling 1 Q13616 123 1.19e-02 76 2 1 0.500 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 Q9H469 123 1.22e-02 78 2 1 0.500 0.013 TF:M02073_1 tf 1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 1 Q9H469 123 1.26e-02 37 2 1 0.500 0.027 REAC:69236 rea 1 G1 Phase 1 Q13616 123 1.26e-02 37 2 1 0.500 0.027 REAC:69231 rea 1 Cyclin D associated events in G1 1 Q13616 123 1.36e-02 40 2 1 0.500 0.025 REAC:2122947 rea 1 NOTCH1 Intracellular Domain Regulates Transcription 1 Q13616 123 1.36e-02 87 2 1 0.500 0.011 TF:M05412_0 tf 1 Factor: ZNF579; motif: NGYGGGGWGGGG; match class: 0 1 Q9H469 123 1.37e-02 459 2 2 1.000 0.004 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q13616,Q9H469 123 1.39e-02 462 2 2 1.000 0.004 GO:0016567 BP 1 protein ubiquitination 1 Q13616,Q9H469 123 1.47e-02 94 2 1 0.500 0.011 TF:M06523_0 tf 1 Factor: ZNF527; motif: KGGAGWATGCGM; match class: 0 1 Q9H469 123 1.52e-02 484 2 2 1.000 0.004 GO:0044257 BP 1 cellular protein catabolic process 1 Q13616,Q9H469 123 1.57e-02 100 2 1 0.500 0.010 TF:M05668_0 tf 1 Factor: ZNF154; motif: NGTGAAATCAGA; match class: 0 1 Q9H469 123 1.59e-02 37 2 1 0.500 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q13616 123 1.60e-02 47 2 1 0.500 0.021 REAC:2894858 rea 1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1 Q13616 123 1.60e-02 47 2 1 0.500 0.021 REAC:2644606 rea 1 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1 Q13616 123 1.60e-02 47 2 1 0.500 0.021 REAC:2644602 rea 1 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1 Q13616 123 1.60e-02 47 2 1 0.500 0.021 REAC:2894862 rea 1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1 Q13616 123 1.60e-02 47 2 1 0.500 0.021 REAC:2644603 rea 1 Signaling by NOTCH1 in Cancer 1 Q13616 123 1.61e-02 8 2 1 0.500 0.125 CORUM:3015 cor 1 p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex 1 Q13616 123 1.61e-02 8 2 1 0.500 0.125 CORUM:2715 cor 1 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) 1 Q13616 123 1.81e-02 9 2 1 0.500 0.111 CORUM:781 cor 1 URI complex (Unconventional prefoldin RPB5 Interactor) 1 Q13616 123 1.83e-02 54 2 1 0.500 0.019 REAC:174113 rea 1 SCF-beta-TrCP mediated degradation of Emi1 1 Q13616 123 1.92e-02 123 2 1 0.500 0.008 TF:M06483_0 tf 1 Factor: ZNF595; motif: NGTGGAGGAWGC; match class: 0 1 Q13616 123 1.93e-02 57 2 1 0.500 0.018 REAC:450294 rea 1 MAP kinase activation in TLR cascade 1 Q13616 123 1.97e-02 58 2 1 0.500 0.017 REAC:5610783 rea 1 Degradation of GLI2 by the proteasome 1 Q13616 123 1.97e-02 58 2 1 0.500 0.017 REAC:5610780 rea 1 Degradation of GLI1 by the proteasome 1 Q13616 123 1.97e-02 58 2 1 0.500 0.017 REAC:5676590 rea 1 NIK-->noncanonical NF-kB signaling 1 Q13616 123 1.97e-02 58 2 1 0.500 0.017 REAC:187577 rea 1 SCF(Skp2)-mediated degradation of p27/p21 1 Q13616 123 1.97e-02 126 2 1 0.500 0.008 TF:M06518_0 tf 1 Factor: znf383; motif: NAMTCCTGGARM; match class: 0 1 Q13616 123 2.00e-02 59 2 1 0.500 0.017 REAC:5607761 rea 1 Dectin-1 mediated noncanonical NF-kB signaling 1 Q13616 123 2.00e-02 59 2 1 0.500 0.017 REAC:1980143 rea 1 Signaling by NOTCH1 1 Q13616 123 2.00e-02 59 2 1 0.500 0.017 REAC:5610785 rea 1 GLI3 is processed to GLI3R by the proteasome 1 Q13616 123 2.04e-02 60 2 1 0.500 0.017 REAC:400253 rea 1 Circadian Clock 1 Q13616 123 2.04e-02 560 2 2 1.000 0.004 GO:0030163 BP 1 protein catabolic process 1 Q13616,Q9H469 123 2.05e-02 131 2 1 0.500 0.008 TF:M05419_0 tf 1 Factor: ZNF499; motif: NGTTCCGGASGC; match class: 0 1 Q9H469 123 2.14e-02 573 2 2 1.000 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q13616,Q9H469 123 2.20e-02 65 2 1 0.500 0.015 REAC:1169091 rea 1 Activation of NF-kappaB in B cells 1 Q13616 123 2.21e-02 11 2 1 0.500 0.091 CORUM:5196 cor 1 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) 1 Q13616 123 2.23e-02 121 2 1 0.500 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 Q13616 123 2.26e-02 15 2 1 0.500 0.067 GO:0030513 BP 1 positive regulation of BMP signaling pathway 1 Q9H469 123 2.31e-02 68 2 1 0.500 0.015 REAC:69656 rea 1 Cyclin A:Cdk2-associated events at S phase entry 1 Q13616 123 2.31e-02 1933 2 2 1.000 0.001 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 Q13616,Q9H469 123 2.34e-02 69 2 1 0.500 0.014 REAC:69202 rea 1 Cyclin E associated events during G1/S transition 1 Q13616 123 2.48e-02 159 2 1 0.500 0.006 TF:M00940_1 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 1 Q9H469 123 2.54e-02 624 2 2 1.000 0.003 GO:1990234 CC 1 transferase complex 1 Q13616,Q9H469 123 2.54e-02 75 2 1 0.500 0.013 REAC:975138 rea 1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1 Q13616 123 2.54e-02 75 2 1 0.500 0.013 REAC:2871837 rea 1 FCERI mediated NF-kB activation 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:975871 rea 1 MyD88 cascade initiated on plasma membrane 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:168176 rea 1 Toll Like Receptor 5 (TLR5) Cascade 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:5668541 rea 1 TNFR2 non-canonical NF-kB pathway 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:168142 rea 1 Toll Like Receptor 10 (TLR10) Cascade 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:168181 rea 1 Toll Like Receptor 7/8 (TLR7/8) Cascade 1 Q13616 123 2.57e-02 76 2 1 0.500 0.013 REAC:975155 rea 1 MyD88 dependent cascade initiated on endosome 1 Q13616 123 2.58e-02 60 2 1 0.500 0.017 KEGG:04350 keg 1 TGF-beta signaling pathway 1 Q13616 123 2.59e-02 2049 2 2 1.000 0.001 TF:M01876_0 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 0 1 Q13616,Q9H469 123 2.64e-02 78 2 1 0.500 0.013 REAC:176408 rea 1 Regulation of APC/C activators between G1/S and early anaphase 1 Q13616 123 2.68e-02 172 2 1 0.500 0.006 TF:M01204_0 tf 1 Factor: Spi-B; motif: AAAAWGMGGAAGTWNSN; match class: 0 1 Q13616 123 2.71e-02 80 2 1 0.500 0.013 REAC:168138 rea 1 Toll Like Receptor 9 (TLR9) Cascade 1 Q13616 123 2.72e-02 148 2 1 0.500 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q13616 123 2.74e-02 81 2 1 0.500 0.012 REAC:195253 rea 1 Degradation of beta-catenin by the destruction complex 1 Q13616 123 2.81e-02 180 2 1 0.500 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 Q9H469 123 2.81e-02 83 2 1 0.500 0.012 REAC:168188 rea 1 Toll Like Receptor TLR6:TLR2 Cascade 1 Q13616 123 2.81e-02 83 2 1 0.500 0.012 REAC:166058 rea 1 MyD88:Mal cascade initiated on plasma membrane 1 Q13616 123 2.81e-02 83 2 1 0.500 0.012 REAC:168179 rea 1 Toll Like Receptor TLR1:TLR2 Cascade 1 Q13616 123 2.81e-02 83 2 1 0.500 0.012 REAC:181438 rea 1 Toll Like Receptor 2 (TLR2) Cascade 1 Q13616 123 2.81e-02 83 2 1 0.500 0.012 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 Q13616 123 2.81e-02 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q13616,Q9H469 123 2.84e-02 84 2 1 0.500 0.012 REAC:453276 rea 1 Regulation of mitotic cell cycle 1 Q13616 123 2.84e-02 84 2 1 0.500 0.012 REAC:174143 rea 1 APC/C-mediated degradation of cell cycle proteins 1 Q13616 123 2.85e-02 662 2 2 1.000 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q13616,Q9H469 123 2.98e-02 88 2 1 0.500 0.011 REAC:168164 rea 1 Toll Like Receptor 3 (TLR3) Cascade 1 Q13616 123 2.98e-02 88 2 1 0.500 0.011 REAC:166166 rea 1 MyD88-independent TLR3/TLR4 cascade 1 Q13616 123 2.98e-02 88 2 1 0.500 0.011 REAC:937061 rea 1 TRIF-mediated TLR3/TLR4 signaling 1 Q13616 123 3.01e-02 89 2 1 0.500 0.011 REAC:202424 rea 1 Downstream TCR signaling 1 Q13616 123 3.02e-02 2213 2 2 1.000 0.001 TF:M07065_1 tf 1 Factor: STAT3; motif: TTCYGGGAAN; match class: 1 1 Q13616,Q9H469 123 3.11e-02 92 2 1 0.500 0.011 REAC:5607764 rea 1 CLEC7A (Dectin-1) signaling 1 Q13616 123 3.21e-02 95 2 1 0.500 0.011 REAC:157118 rea 1 Signaling by NOTCH 1 Q13616 123 3.28e-02 97 2 1 0.500 0.010 REAC:5610787 rea 1 Hedgehog 'off' state 1 Q13616 123 3.37e-02 216 2 1 0.500 0.005 TF:M04190_0 tf 1 Factor: TCF3; motif: NRCACCTGNN; match class: 0 1 Q9H469 123 3.37e-02 216 2 1 0.500 0.005 TF:M02062_1 tf 1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 1 Q9H469 123 3.38e-02 100 2 1 0.500 0.010 REAC:166054 rea 1 Activated TLR4 signalling 1 Q13616 123 3.39e-02 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q13616,Q9H469 123 3.44e-02 727 2 2 1.000 0.003 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q13616,Q9H469 123 3.49e-02 2379 2 2 1.000 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q13616,Q9H469 123 3.58e-02 230 2 1 0.500 0.004 TF:M07298_0 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 0 1 Q13616 123 3.58e-02 106 2 1 0.500 0.009 REAC:202403 rea 1 TCR signaling 1 Q13616 123 3.65e-02 108 2 1 0.500 0.009 REAC:166016 rea 1 Toll Like Receptor 4 (TLR4) Cascade 1 Q13616 123 3.79e-02 112 2 1 0.500 0.009 REAC:5621481 rea 1 C-type lectin receptors (CLRs) 1 Q13616 123 3.82e-02 2489 2 2 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 Q13616,Q9H469 123 3.86e-02 2500 2 2 1.000 0.001 TF:M01209_0 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 0 1 Q13616,Q9H469 123 3.89e-02 115 2 1 0.500 0.009 REAC:69206 rea 1 G1/S Transition 1 Q13616 123 3.95e-02 254 2 1 0.500 0.004 TF:M01876_1 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 1 1 Q9H469 123 4.03e-02 259 2 1 0.500 0.004 TF:M00764_1 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 1 1 Q9H469 123 4.06e-02 27 2 1 0.500 0.037 GO:0009953 BP 1 dorsal/ventral pattern formation 1 Q9H469 123 4.09e-02 263 2 1 0.500 0.004 TF:M05883_1 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 1 1 Q9H469 123 4.14e-02 426 2 2 1.000 0.005 MI:mmu-miR-471 mi 1 MI:mmu-miR-471 1 Q13616,Q9H469 123 4.15e-02 123 2 1 0.500 0.008 REAC:5358351 rea 1 Signaling by Hedgehog 1 Q13616 123 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 Q13616 123 4.24e-02 99 2 1 0.500 0.010 KEGG:04114 keg 1 Oocyte meiosis 1 Q13616 123 4.25e-02 126 2 1 0.500 0.008 REAC:69242 rea 1 S Phase 1 Q13616 123 4.29e-02 127 2 1 0.500 0.008 REAC:168898 rea 1 Toll-Like Receptors Cascades 1 Q13616 123 4.54e-02 292 2 1 0.500 0.003 TF:M05837_0 tf 1 Factor: ZFP2; motif: NCCWCGGGRATA; match class: 0 1 Q13616 123 4.66e-02 138 2 1 0.500 0.007 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 Q13616 123 4.86e-02 313 2 1 0.500 0.003 TF:M03553_1 tf 1 Factor: KLF3; motif: CCMCACCCNG; match class: 1 1 Q9H469 123 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q13616 123 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q13616 123 5.00e-02 117 2 1 0.500 0.009 KEGG:04110 keg 1 Cell cycle 1 Q13616 123 5.00e-02 876 2 2 1.000 0.002 GO:0009057 BP 1 macromolecule catabolic process 1 Q13616,Q9H469 123 5.00e-02 468 2 2 1.000 0.004 MI:hsa-miR-493 mi 1 MI:hsa-miR-493 1 Q13616,Q9H469 123 5.00e-02 25 2 1 0.500 0.040 CORUM:5233 cor 1 TNF-alpha/NF-kappa B signaling complex 5 1 Q13616 123 5.00e-02 1457 2 2 1.000 0.001 REAC:168256 rea 1 Immune System 1 Q13616,Q9H469 124 2.86e-13 14 7 5 0.714 0.357 REAC:4839748 rea 1 AMER1 mutants destabilize the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.86e-13 14 7 5 0.714 0.357 REAC:4839744 rea 1 truncated APC mutants destabilize the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.86e-13 14 7 5 0.714 0.357 REAC:4839735 rea 1 AXIN mutants destabilize the destruction complex, activating WNT signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.86e-13 14 7 5 0.714 0.357 REAC:5467340 rea 1 AXIN missense mutants destabilize the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.86e-13 14 7 5 0.714 0.357 REAC:5467337 rea 1 APC truncation mutants have impaired AXIN binding 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.86e-13 14 7 5 0.714 0.357 REAC:5467348 rea 1 Truncations of AMER1 destabilize the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:5358752 rea 1 T41 mutants of beta-catenin aren't phosphorylated 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:5358751 rea 1 S45 mutants of beta-catenin aren't phosphorylated 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:4839743 rea 1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:5358749 rea 1 S37 mutants of beta-catenin aren't phosphorylated 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:5339716 rea 1 Misspliced GSK3beta mutants stabilize beta-catenin 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.30e-13 15 7 5 0.714 0.333 REAC:5358747 rea 1 S33 mutants of beta-catenin aren't phosphorylated 1 Q13362,Q14738,P67775,P30154,Q16537 124 6.25e-13 16 7 5 0.714 0.312 REAC:432142 rea 1 Platelet sensitization by LDL 1 Q13362,Q14738,P67775,P30154,Q16537 124 8.85e-13 17 7 5 0.714 0.294 REAC:196299 rea 1 Beta-catenin phosphorylation cascade 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.66e-12 19 7 5 0.714 0.263 REAC:389513 rea 1 CTLA4 inhibitory signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 7.58e-12 25 7 5 0.714 0.200 REAC:5673000 rea 1 RAF activation 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.15e-11 27 7 5 0.714 0.185 REAC:4791275 rea 1 Signaling by WNT in cancer 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.69e-11 29 7 5 0.714 0.172 REAC:4641262 rea 1 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.62e-11 35 7 5 0.714 0.143 REAC:5675221 rea 1 Negative regulation of MAPK pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.07e-10 53 7 5 0.714 0.094 REAC:388841 rea 1 Costimulation by the CD28 family 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.08e-09 64 7 5 0.714 0.078 REAC:6811558 rea 1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.84e-09 71 7 5 0.714 0.070 REAC:199418 rea 1 Negative regulation of the PI3K/AKT network 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.98e-09 72 7 5 0.714 0.069 REAC:418346 rea 1 Platelet homeostasis 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.61e-09 81 7 5 0.714 0.062 REAC:195253 rea 1 Degradation of beta-catenin by the destruction complex 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.00e-08 99 7 5 0.714 0.051 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:1250342 rea 1 PI3K events in ERBB4 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:5654710 rea 1 PI-3K cascade:FGFR3 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:5654720 rea 1 PI-3K cascade:FGFR4 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:5654695 rea 1 PI-3K cascade:FGFR2 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:1257604 rea 1 PIP3 activates AKT signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.06e-08 100 7 5 0.714 0.050 REAC:5654689 rea 1 PI-3K cascade:FGFR1 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.17e-08 102 7 5 0.714 0.049 REAC:198203 rea 1 PI3K/AKT activation 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.23e-08 103 7 5 0.714 0.049 REAC:180292 rea 1 GAB1 signalosome 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.35e-08 105 7 5 0.714 0.048 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.49e-08 107 7 5 0.714 0.047 REAC:68877 rea 1 Mitotic Prometaphase 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.96e-08 113 7 5 0.714 0.044 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.18e-08 7 7 3 0.429 0.429 REAC:163767 rea 1 PP2A-mediated dephosphorylation of key metabolic factors 1 Q14738,P67775,P30154 124 8.77e-08 83 7 5 0.714 0.060 KEGG:03015 keg 1 mRNA surveillance pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.17e-07 161 7 5 0.714 0.031 REAC:2467813 rea 1 Separation of Sister Chromatids 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.32e-07 165 7 5 0.714 0.030 REAC:201681 rea 1 TCF dependent signaling in response to WNT 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.37e-07 12 7 3 0.429 0.250 REAC:202670 rea 1 ERKs are inactivated 1 Q14738,P67775,P30154 124 1.45e-07 168 7 5 0.714 0.030 REAC:1168372 rea 1 Downstream signaling events of B Cell Receptor (BCR) 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.63e-07 172 7 5 0.714 0.029 REAC:68882 rea 1 Mitotic Anaphase 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.68e-07 173 7 5 0.714 0.029 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.15e-07 99 7 5 0.714 0.051 KEGG:04114 keg 1 Oocyte meiosis 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.48e-07 187 7 5 0.714 0.027 REAC:983705 rea 1 Signaling by the B Cell Receptor (BCR) 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.76e-07 104 7 5 0.714 0.048 KEGG:04071 keg 1 Sphingolipid signaling pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.91e-07 193 7 5 0.714 0.026 REAC:1250347 rea 1 SHC1 events in ERBB4 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.91e-07 193 7 5 0.714 0.026 REAC:180336 rea 1 SHC1 events in EGFR signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.91e-07 193 7 5 0.714 0.026 REAC:179812 rea 1 GRB2 events in EGFR signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.91e-07 193 7 5 0.714 0.026 REAC:112412 rea 1 SOS-mediated signalling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.91e-07 193 7 5 0.714 0.026 REAC:5673001 rea 1 RAF/MAP kinase cascade 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.98e-07 194 7 5 0.714 0.026 REAC:5654693 rea 1 FRS-mediated FGFR1 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.98e-07 194 7 5 0.714 0.026 REAC:5654706 rea 1 FRS-mediated FGFR3 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.98e-07 194 7 5 0.714 0.026 REAC:5654700 rea 1 FRS-mediated FGFR2 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.98e-07 194 7 5 0.714 0.026 REAC:5654712 rea 1 FRS-mediated FGFR4 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.06e-07 195 7 5 0.714 0.026 REAC:187706 rea 1 Signalling to p38 via RIT and RIN 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.14e-07 196 7 5 0.714 0.026 REAC:170984 rea 1 ARMS-mediated activation 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.19e-07 107 7 5 0.714 0.047 KEGG:04152 keg 1 AMPK signaling pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.22e-07 197 7 5 0.714 0.025 REAC:170968 rea 1 Frs2-mediated activation 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.30e-07 198 7 5 0.714 0.025 REAC:5684996 rea 1 MAPK1/MAPK3 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.39e-07 199 7 5 0.714 0.025 REAC:169893 rea 1 Prolonged ERK activation events 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.39e-07 199 7 5 0.714 0.025 REAC:2586552 rea 1 Signaling by Leptin 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.74e-07 203 7 5 0.714 0.025 REAC:167044 rea 1 Signalling to RAS 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.74e-07 203 7 5 0.714 0.025 REAC:912526 rea 1 Interleukin receptor SHC signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.84e-07 111 7 5 0.714 0.045 KEGG:04728 keg 1 Dopaminergic synapse 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.03e-07 206 7 5 0.714 0.024 REAC:5218921 rea 1 VEGFR2 mediated cell proliferation 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.33e-07 209 7 5 0.714 0.024 REAC:451927 rea 1 Interleukin-2 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.33e-07 209 7 5 0.714 0.024 REAC:187687 rea 1 Signalling to ERKs 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.76e-07 213 7 5 0.714 0.023 REAC:2871796 rea 1 FCERI mediated MAPK activation 1 Q13362,Q14738,P67775,P30154,Q16537 124 5.22e-07 217 7 5 0.714 0.023 REAC:375165 rea 1 NCAM signaling for neurite out-growth 1 Q13362,Q14738,P67775,P30154,Q16537 124 5.34e-07 218 7 5 0.714 0.023 REAC:512988 rea 1 Interleukin-3, 5 and GM-CSF signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 6.18e-07 122 7 5 0.714 0.041 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 Q13362,Q14738,P67775,P30154,Q16537 124 7.14e-07 231 7 5 0.714 0.022 REAC:195258 rea 1 RHO GTPase Effectors 1 Q13362,Q14738,P67775,P30154,Q16537 124 7.29e-07 232 7 5 0.714 0.022 REAC:5683057 rea 1 MAPK family signaling cascades 1 Q13362,Q14738,P67775,P30154,Q16537 124 8.23e-07 21 7 3 0.429 0.143 REAC:198753 rea 1 ERK/MAPK targets 1 Q14738,P67775,P30154 124 8.23e-07 21 7 3 0.429 0.143 REAC:180024 rea 1 DARPP-32 events 1 Q14738,P67775,P30154 124 8.64e-07 240 7 5 0.714 0.021 REAC:112399 rea 1 IRS-mediated signalling 1 Q13362,Q14738,P67775,P30154,Q16537 124 8.82e-07 241 7 5 0.714 0.021 REAC:2428928 rea 1 IRS-related events triggered by IGF1R 1 Q13362,Q14738,P67775,P30154,Q16537 124 8.82e-07 241 7 5 0.714 0.021 REAC:2428924 rea 1 IGF1R signaling cascade 1 Q13362,Q14738,P67775,P30154,Q16537 124 9.00e-07 242 7 5 0.714 0.021 REAC:2404192 rea 1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1 Q13362,Q14738,P67775,P30154,Q16537 124 9.00e-07 242 7 5 0.714 0.021 REAC:74751 rea 1 Insulin receptor signalling cascade 1 Q13362,Q14738,P67775,P30154,Q16537 124 9.97e-07 247 7 5 0.714 0.020 REAC:195721 rea 1 Signaling by Wnt 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.12e-06 253 7 5 0.714 0.020 REAC:68886 rea 1 M Phase 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.25e-06 24 7 3 0.429 0.125 REAC:198725 rea 1 Nuclear Events (kinase and transcription factor activation) 1 Q14738,P67775,P30154 124 1.36e-06 263 7 5 0.714 0.019 REAC:74752 rea 1 Signaling by Insulin receptor 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.58e-06 271 7 5 0.714 0.018 REAC:1433557 rea 1 Signaling by SCF-KIT 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.61e-06 272 7 5 0.714 0.018 REAC:1236394 rea 1 Signaling by ERBB4 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.61e-06 272 7 5 0.714 0.018 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.79e-06 278 7 5 0.714 0.018 REAC:194138 rea 1 Signaling by VEGF 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.86e-06 280 7 5 0.714 0.018 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.86e-06 280 7 5 0.714 0.018 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.86e-06 280 7 5 0.714 0.018 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.89e-06 281 7 5 0.714 0.018 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.96e-06 283 7 5 0.714 0.018 REAC:5654743 rea 1 Signaling by FGFR4 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.96e-06 283 7 5 0.714 0.018 REAC:5654741 rea 1 Signaling by FGFR3 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.03e-06 285 7 5 0.714 0.018 REAC:5654736 rea 1 Signaling by FGFR1 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.10e-06 287 7 5 0.714 0.017 REAC:449147 rea 1 Signaling by Interleukins 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.10e-06 287 7 5 0.714 0.017 REAC:881907 rea 1 Gastrin-CREB signalling pathway via PKC and MAPK 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.21e-06 290 7 5 0.714 0.017 REAC:2424491 rea 1 DAP12 signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.29e-06 292 7 5 0.714 0.017 REAC:186763 rea 1 Downstream signal transduction 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.37e-06 294 7 5 0.714 0.017 REAC:2172127 rea 1 DAP12 interactions 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.50e-06 30 7 3 0.429 0.100 REAC:450282 rea 1 MAPK targets/ Nuclear events mediated by MAP kinases 1 Q14738,P67775,P30154 124 2.80e-06 304 7 5 0.714 0.016 REAC:177929 rea 1 Signaling by EGFR 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.84e-06 305 7 5 0.714 0.016 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.03e-06 309 7 5 0.714 0.016 REAC:5654738 rea 1 Signaling by FGFR2 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.03e-06 309 7 5 0.714 0.016 REAC:5663202 rea 1 Diseases of signal transduction 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.05e-06 32 7 3 0.429 0.094 REAC:70171 rea 1 Glycolysis 1 Q14738,P67775,P30154 124 3.05e-06 32 7 3 0.429 0.094 REAC:6804757 rea 1 Regulation of TP53 Degradation 1 Q13362,P67775,P30154 124 3.13e-06 311 7 5 0.714 0.016 REAC:190236 rea 1 Signaling by FGFR 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.18e-06 312 7 5 0.714 0.016 REAC:186797 rea 1 Signaling by PDGF 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.36e-06 33 7 3 0.429 0.091 REAC:6806003 rea 1 Regulation of TP53 Expression and Degradation 1 Q13362,P67775,P30154 124 3.72e-06 322 7 5 0.714 0.016 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 Q13362,Q14738,P67775,P30154,Q16537 124 4.73e-06 338 7 5 0.714 0.015 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.01e-05 394 7 5 0.714 0.013 REAC:166520 rea 1 Signalling by NGF 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.78e-05 57 7 3 0.429 0.053 REAC:450294 rea 1 MAP kinase activation in TLR cascade 1 Q14738,P67775,P30154 124 1.82e-05 444 7 5 0.714 0.011 REAC:109582 rea 1 Hemostasis 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.86e-05 446 7 5 0.714 0.011 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.90e-05 448 7 5 0.714 0.011 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.14e-05 459 7 5 0.714 0.011 REAC:422475 rea 1 Axon guidance 1 Q13362,Q14738,P67775,P30154,Q16537 124 2.56e-05 257 7 5 0.714 0.019 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 Q13362,Q14738,P67775,P30154,Q16537 124 3.76e-05 73 7 3 0.429 0.041 REAC:111885 rea 1 Opioid Signalling 1 Q14738,P67775,P30154 124 4.04e-05 10 7 2 0.286 0.200 REAC:2465910 rea 1 MASTL Facilitates Mitotic Progression 1 P67775,P30154 124 4.08e-05 75 7 3 0.429 0.040 REAC:975138 rea 1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1 Q14738,P67775,P30154 124 4.25e-05 76 7 3 0.429 0.039 REAC:168181 rea 1 Toll Like Receptor 7/8 (TLR7/8) Cascade 1 Q14738,P67775,P30154 124 4.25e-05 76 7 3 0.429 0.039 REAC:168142 rea 1 Toll Like Receptor 10 (TLR10) Cascade 1 Q14738,P67775,P30154 124 4.25e-05 76 7 3 0.429 0.039 REAC:975155 rea 1 MyD88 dependent cascade initiated on endosome 1 Q14738,P67775,P30154 124 4.25e-05 76 7 3 0.429 0.039 REAC:168176 rea 1 Toll Like Receptor 5 (TLR5) Cascade 1 Q14738,P67775,P30154 124 4.25e-05 76 7 3 0.429 0.039 REAC:975871 rea 1 MyD88 cascade initiated on plasma membrane 1 Q14738,P67775,P30154 124 4.42e-05 77 7 3 0.429 0.039 REAC:70326 rea 1 Glucose metabolism 1 Q14738,P67775,P30154 124 4.96e-05 80 7 3 0.429 0.037 REAC:168138 rea 1 Toll Like Receptor 9 (TLR9) Cascade 1 Q14738,P67775,P30154 124 5.05e-05 547 7 5 0.714 0.009 REAC:1640170 rea 1 Cell Cycle 1 Q13362,Q14738,P67775,P30154,Q16537 124 5.54e-05 83 7 3 0.429 0.036 REAC:168179 rea 1 Toll Like Receptor TLR1:TLR2 Cascade 1 Q14738,P67775,P30154 124 5.54e-05 83 7 3 0.429 0.036 REAC:166058 rea 1 MyD88:Mal cascade initiated on plasma membrane 1 Q14738,P67775,P30154 124 5.54e-05 83 7 3 0.429 0.036 REAC:168188 rea 1 Toll Like Receptor TLR6:TLR2 Cascade 1 Q14738,P67775,P30154 124 5.54e-05 83 7 3 0.429 0.036 REAC:181438 rea 1 Toll Like Receptor 2 (TLR2) Cascade 1 Q14738,P67775,P30154 124 6.55e-05 577 7 5 0.714 0.009 REAC:372790 rea 1 Signaling by GPCR 1 Q13362,Q14738,P67775,P30154,Q16537 124 6.60e-05 88 7 3 0.429 0.034 REAC:937061 rea 1 TRIF-mediated TLR3/TLR4 signaling 1 Q14738,P67775,P30154 124 6.60e-05 88 7 3 0.429 0.034 REAC:168164 rea 1 Toll Like Receptor 3 (TLR3) Cascade 1 Q14738,P67775,P30154 124 6.60e-05 88 7 3 0.429 0.034 REAC:166166 rea 1 MyD88-independent TLR3/TLR4 cascade 1 Q14738,P67775,P30154 124 6.99e-05 13 7 2 0.286 0.154 REAC:113501 rea 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1 P67775,P30154 124 8.04e-05 94 7 3 0.429 0.032 REAC:163685 rea 1 Integration of energy metabolism 1 Q14738,P67775,P30154 124 8.87e-05 614 7 5 0.714 0.008 REAC:1280218 rea 1 Adaptive Immune System 1 Q13362,Q14738,P67775,P30154,Q16537 124 9.68e-05 100 7 3 0.429 0.030 REAC:166054 rea 1 Activated TLR4 signalling 1 Q14738,P67775,P30154 124 1.22e-04 108 7 3 0.429 0.028 REAC:166016 rea 1 Toll Like Receptor 4 (TLR4) Cascade 1 Q14738,P67775,P30154 124 1.89e-04 718 7 5 0.714 0.007 REAC:1266738 rea 1 Developmental Biology 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.92e-04 720 7 5 0.714 0.007 REAC:1643685 rea 1 Disease 1 Q13362,Q14738,P67775,P30154,Q16537 124 1.97e-04 127 7 3 0.429 0.024 REAC:168898 rea 1 Toll-Like Receptors Cascades 1 Q14738,P67775,P30154 124 2.06e-04 22 7 2 0.286 0.091 REAC:69273 rea 1 Cyclin A/B1 associated events during G2/M transition 1 P67775,P30154 124 3.23e-04 150 7 3 0.429 0.020 REAC:5633007 rea 1 Regulation of TP53 Activity 1 Q13362,P67775,P30154 124 3.67e-04 41 7 3 0.429 0.073 GO:0019888 MF 1 protein phosphatase regulator activity 1 Q13362,Q14738,Q16537 124 4.98e-04 34 7 2 0.286 0.059 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 P67775,P30154 124 5.90e-04 37 7 2 0.286 0.054 REAC:69231 rea 1 Cyclin D associated events in G1 1 P67775,P30154 124 5.90e-04 37 7 2 0.286 0.054 REAC:69236 rea 1 G1 Phase 1 P67775,P30154 124 6.50e-04 5 7 2 0.286 0.400 CORUM:5876 cor 1 PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex 1 P67775,P30154 124 6.84e-04 938 7 5 0.714 0.005 REAC:168249 rea 1 Innate Immune System 1 Q13362,Q14738,P67775,P30154,Q16537 124 9.67e-04 398 7 3 0.429 0.008 TF:M02107_0 tf 1 Factor: NF-YC; motif: NRGCCAATYAGMGC; match class: 0 1 Q14738,Q13136,Q16537 124 1.38e-03 246 7 3 0.429 0.012 REAC:71387 rea 1 Metabolism of carbohydrates 1 Q14738,P67775,P30154 124 2.62e-03 3578 7 6 0.857 0.002 TF:M04141_0 tf 1 Factor: TEAD1; motif: NRCATTCCWN; match class: 0 1 Q13362,P67775,Q13136,P53365,P30154,Q16537 124 3.25e-03 331 7 3 0.429 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q13362,P67775,P30154 124 3.30e-03 6 7 1 0.143 0.167 TF:M00966_1 tf 1 Factor: VDR,; motif: RRTGNMCYTNNTGAMCCNYNT; match class: 1 1 Q13136 124 3.69e-03 93 7 2 0.286 0.022 REAC:68875 rea 1 Mitotic Prophase 1 P67775,P30154 124 3.90e-03 1 7 1 0.143 1.000 OMIM:616355 omi 1 MENTAL RETARDATION, AUTOSOMAL DOMINANT 35; MRD35 1 Q14738 124 4.94e-03 9 7 1 0.143 0.111 TF:M06035_0 tf 1 Factor: ZNF749; motif: NCKTGCGGCCGC; match class: 0 1 P67775 124 5.41e-03 1457 7 5 0.714 0.003 REAC:168256 rea 1 Immune System 1 Q13362,Q14738,P67775,P30154,Q16537 124 5.60e-03 115 7 2 0.286 0.017 REAC:69206 rea 1 G1/S Transition 1 P67775,P30154 124 6.22e-03 226 7 2 0.286 0.009 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q14738,P30154 124 7.13e-03 13 7 1 0.143 0.077 TF:M06681_0 tf 1 Factor: ZNF436; motif: NGKGAAAGCCRC; match class: 0 1 Q13136 124 7.13e-03 13 7 1 0.143 0.077 TF:M06864_0 tf 1 Factor: znf585B; motif: NTGGCCAAAMGM; match class: 0 1 P53365 124 7.68e-03 5386 7 7 1.000 0.001 HPA:012020_02 hpa 1 endometrium 2; glandular cells[Uncertain,Medium] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 7.73e-03 1575 7 5 0.714 0.003 REAC:162582 rea 1 Signal Transduction 1 Q13362,Q14738,P67775,P30154,Q16537 124 7.99e-03 138 7 2 0.286 0.014 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P67775,P30154 124 8.25e-03 51 7 2 0.286 0.039 KEGG:04730 keg 1 Long-term depression 1 P67775,P30154 124 9.12e-03 5520 7 7 1.000 0.001 HPA:011020_02 hpa 1 endometrium 1; glandular cells[Uncertain,Medium] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 9.31e-03 17 7 1 0.143 0.059 TF:M05887_0 tf 1 Factor: ZNF837; motif: KGGGWAGGCCGC; match class: 0 1 P67775 124 1.09e-02 17 7 2 0.286 0.118 GO:0000159 CC 1 protein phosphatase type 2A complex 1 Q13362,P67775 124 1.14e-02 60 7 2 0.286 0.033 KEGG:04350 keg 1 TGF-beta signaling pathway 1 P67775,P30154 124 1.21e-02 171 7 2 0.286 0.012 REAC:69275 rea 1 G2/M Transition 1 P67775,P30154 124 1.22e-02 320 7 2 0.286 0.006 TF:M07259_1 tf 1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1 Q13362,Q16537 124 1.22e-02 272 7 2 0.286 0.007 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 P67775,P53365 124 1.24e-02 173 7 2 0.286 0.012 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 P67775,P30154 124 1.26e-02 5782 7 7 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 1.30e-02 4759 7 6 0.857 0.001 TF:M07370_1 tf 1 Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 1 Q13362,Q14738,P67775,P53365,P30154,Q16537 124 1.31e-02 4768 7 6 0.857 0.001 TF:M02036_0 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 0 1 Q13362,Q14738,P67775,Q13136,P53365,Q16537 124 1.33e-02 1963 7 4 0.571 0.002 TF:M07256_0 tf 1 Factor: FXR:RXR; motif: RGGTCANTGACCTN; match class: 0 1 Q13362,Q14738,P67775,Q13136 124 1.37e-02 25 7 1 0.143 0.040 TF:M05428_0 tf 1 Factor: RP58; motif: NGGGGCAAGSCM; match class: 0 1 Q13362 124 1.40e-02 1989 7 4 0.571 0.002 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q13362,Q13136,P53365,Q16537 124 1.40e-02 13 7 1 0.143 0.077 REAC:2995410 rea 1 Nuclear Envelope Reassembly 1 P67775 124 1.40e-02 13 7 1 0.143 0.077 REAC:2995383 rea 1 Initiation of Nuclear Envelope Reformation 1 P67775 124 1.42e-02 26 7 1 0.143 0.038 TF:M04051_0 tf 1 Factor: NF-AT2; motif: NATGGAAANWNANTTTYCMN; match class: 0 1 P30154 124 1.51e-02 14 7 1 0.143 0.071 REAC:264642 rea 1 Acetylcholine Neurotransmitter Release Cycle 1 Q13136 124 1.62e-02 15 7 1 0.143 0.067 REAC:181429 rea 1 Serotonin Neurotransmitter Release Cycle 1 Q13136 124 1.62e-02 15 7 1 0.143 0.067 REAC:1295596 rea 1 Spry regulation of FGF signaling 1 P67775 124 1.72e-02 16 7 1 0.143 0.062 REAC:181430 rea 1 Norepinephrine Neurotransmitter Release Cycle 1 Q13136 124 1.75e-02 32 7 1 0.143 0.031 TF:M06591_0 tf 1 Factor: ZNF681; motif: NGGGATAGAAGA; match class: 0 1 Q13136 124 1.84e-02 397 7 2 0.286 0.005 TF:M07309_1 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 1 1 P67775,Q13136 124 1.91e-02 35 7 1 0.143 0.029 TF:M05957_0 tf 1 Factor: ZNF306; motif: KGGGTAAGMCGM; match class: 0 1 Q14738 124 1.91e-02 1142 7 3 0.429 0.003 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 Q14738,Q13136,Q16537 124 1.96e-02 628 7 3 0.429 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 Q13362,P67775,P30154 124 2.06e-02 81 7 2 0.286 0.025 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 P67775,P30154 124 2.07e-02 8 7 1 0.143 0.125 HP:0005988 hp 1 Congenital muscular torticollis 1 Q14738 124 2.10e-02 1182 7 3 0.429 0.003 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 Q14738,P67775,Q13136 124 2.15e-02 20 7 1 0.143 0.050 REAC:210500 rea 1 Glutamate Neurotransmitter Release Cycle 1 Q13136 124 2.15e-02 20 7 1 0.143 0.050 REAC:5654732 rea 1 Negative regulation of FGFR3 signaling 1 P67775 124 2.15e-02 20 7 1 0.143 0.050 REAC:212676 rea 1 Dopamine Neurotransmitter Release Cycle 1 Q13136 124 2.16e-02 381 7 2 0.286 0.005 MI:hsa-miR-609 mi 1 MI:hsa-miR-609 1 Q14738,Q16537 124 2.17e-02 3580 7 5 0.714 0.001 TF:M01151_0 tf 1 Factor: DMRT7; motif: TTGTTACAWTKTKG; match class: 0 1 Q14738,Q13136,P53365,P30154,Q16537 124 2.26e-02 21 7 1 0.143 0.048 REAC:5654733 rea 1 Negative regulation of FGFR4 signaling 1 P67775 124 2.40e-02 5322 7 6 0.857 0.001 TF:M00749_1 tf 1 Factor: SREBP-1; motif: CACSCCA; match class: 1 1 Q13362,P67775,Q13136,P53365,P30154,Q16537 124 2.45e-02 45 7 1 0.143 0.022 TF:M05942_0 tf 1 Factor: ZNF700; motif: NTGTCAAAATCN; match class: 0 1 Q16537 124 2.53e-02 7530 7 7 1.000 0.001 TF:M07059_0 tf 1 Factor: POU2F1; motif: ATGCAAATN; match class: 0 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 2.58e-02 24 7 1 0.143 0.042 REAC:5654727 rea 1 Negative regulation of FGFR2 signaling 1 P67775 124 2.58e-02 24 7 1 0.143 0.042 REAC:5654726 rea 1 Negative regulation of FGFR1 signaling 1 P67775 124 2.63e-02 5412 7 6 0.857 0.001 TF:M03833_0 tf 1 Factor: NKX3A; motif: NCACTTANTYN; match class: 0 1 Q13362,Q14738,P67775,Q13136,P53365,Q16537 124 2.64e-02 92 7 2 0.286 0.022 KEGG:05160 keg 1 Hepatitis C 1 P67775,P30154 124 2.72e-02 489 7 2 0.286 0.004 TF:M06850_0 tf 1 Factor: ZNF96; motif: NGGWRCGGAGGA; match class: 0 1 Q13136,Q16537 124 2.79e-02 7633 7 7 1.000 0.001 TF:M02012_0 tf 1 Factor: HIF-1alpha; motif: NCACGT; match class: 0 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 2.81e-02 1316 7 3 0.429 0.002 TF:M04182_0 tf 1 Factor: NEUROD2; motif: RMCATATGKY; match class: 0 1 P53365,P30154,Q16537 124 2.84e-02 440 7 2 0.286 0.005 MI:hsa-miR-488 mi 1 MI:hsa-miR-488 1 Q13136,P53365 124 2.89e-02 7672 7 7 1.000 0.001 TF:M00196_1 tf 1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 2.90e-02 1333 7 3 0.429 0.002 TF:M07372_0 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 0 1 Q14738,P30154,Q16537 124 2.96e-02 6530 7 7 1.000 0.001 HPA:015010_02 hpa 1 fallopian tube; glandular cells[Uncertain,Medium] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 2.96e-02 512 7 2 0.286 0.004 TF:M07405_0 tf 1 Factor: SREBP-1; motif: RTCACCCCAY; match class: 0 1 P53365,P30154 124 3.07e-02 1361 7 3 0.429 0.002 TF:M01661_0 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 0 1 Q14738,P30154,Q16537 124 3.13e-02 7759 7 7 1.000 0.001 TF:M01177_1 tf 1 Factor: SREBP-2; motif: NNGYCACNNSMN; match class: 1 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 3.15e-02 3900 7 5 0.714 0.001 TF:M07226_0 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 0 1 Q13362,P67775,Q13136,P53365,Q16537 124 3.20e-02 59 7 1 0.143 0.017 TF:M04291_1 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 1 1 Q14738 124 3.23e-02 7796 7 7 1.000 0.001 TF:M03807_0 tf 1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 0 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 3.25e-02 456 7 2 0.286 0.004 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 P67775,P53365 124 3.30e-02 542 7 2 0.286 0.004 TF:M06632_0 tf 1 Factor: ZNF717; motif: GGGAAAAAGA; match class: 0 1 P67775,P30154 124 3.36e-02 62 7 1 0.143 0.016 TF:M06179_0 tf 1 Factor: ZNF445; motif: NGGATAAAGGA; match class: 0 1 P67775 124 3.39e-02 550 7 2 0.286 0.004 TF:M02017_1 tf 1 Factor: HSF1; motif: GAANNTTCTRGNAN; match class: 1 1 Q13362,Q16537 124 3.48e-02 7879 7 7 1.000 0.001 TF:M00008_1 tf 1 Factor: Sp1; motif: GGGGCGGGGT; match class: 1 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 3.56e-02 1221 7 3 0.429 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 P67775,P53365,P30154 124 3.57e-02 4013 7 5 0.714 0.001 TF:M03843_0 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 0 1 P67775,Q13136,P53365,P30154,Q16537 124 3.61e-02 6719 7 7 1.000 0.001 HPA:024010_02 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,Medium] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 3.64e-02 572 7 2 0.286 0.003 TF:M07367_0 tf 1 Factor: Slug; motif: SSSNNNKCACCTGN; match class: 0 1 P67775,Q13136 124 3.68e-02 2620 7 4 0.571 0.002 TF:M07309_0 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 0 1 P67775,Q13136,P53365,P30154 124 3.68e-02 575 7 2 0.286 0.003 TF:M03913_0 tf 1 Factor: KLF14; motif: NRCCACGCCCMCYN; match class: 0 1 Q13362,Q13136 124 3.69e-02 507 7 2 0.286 0.004 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 Q14738,Q13136 124 3.74e-02 35 7 1 0.143 0.029 REAC:112310 rea 1 Neurotransmitter Release Cycle 1 Q13136 124 3.75e-02 581 7 2 0.286 0.003 TF:M01666_0 tf 1 Factor: STAT4; motif: TTCMNAGAADHNMA; match class: 0 1 Q13362,P30154 124 3.80e-02 111 7 2 0.286 0.018 KEGG:04530 keg 1 Tight junction 1 P67775,P30154 124 3.83e-02 4080 7 5 0.714 0.001 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 Q13362,Q14738,Q13136,P53365,P30154 124 3.89e-02 72 7 1 0.143 0.014 TF:M06363_0 tf 1 Factor: ZNF730; motif: NNGGTGGACCGC; match class: 0 1 Q13362 124 4.02e-02 531 7 2 0.286 0.004 MI:hsa-miR-548c-5p mi 1 MI:hsa-miR-548c-5p 1 P67775,Q13136 124 4.11e-02 76 7 1 0.143 0.013 TF:M01208_1 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 1 1 P53365 124 4.12e-02 3521 7 5 0.714 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q13362,P67775,Q13136,P30154,Q16537 124 4.13e-02 3523 7 5 0.714 0.001 HPA:039040_01 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Low] 1 P67775,Q13136,P53365,P30154,Q16537 124 4.18e-02 1530 7 3 0.429 0.002 TF:M04363_0 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 0 1 Q13362,Q13136,Q16537 124 4.18e-02 1530 7 3 0.429 0.002 TF:M04357_0 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 0 1 Q13362,Q13136,Q16537 124 4.29e-02 6886 7 7 1.000 0.001 HPA:002020 hpa 1 appendix; lymphoid tissue 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 4.30e-02 1547 7 3 0.429 0.002 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 P67775,Q13136,Q16537 124 4.30e-02 1547 7 3 0.429 0.002 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 P67775,Q13136,Q16537 124 4.31e-02 6889 7 7 1.000 0.001 HPA:001010_02 hpa 1 adrenal gland; glandular cells[Uncertain,Medium] 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 4.34e-02 1317 7 3 0.429 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 P67775,P53365,P30154 124 4.34e-02 1553 7 3 0.429 0.002 TF:M00801_1 tf 1 Factor: CREB; motif: CGTCAN; match class: 1 1 Q14738,P67775,P53365 124 4.42e-02 82 7 1 0.143 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 Q13136 124 4.45e-02 1567 7 3 0.429 0.002 TF:M07361_0 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 0 1 Q13136,P53365,Q16537 124 4.59e-02 6952 7 7 1.000 0.001 HPA:023010 hpa 1 lymph node; germinal center cells 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 4.62e-02 651 7 2 0.286 0.003 TF:M01123_0 tf 1 Factor: Nanog; motif: GGGNCCATTKCC; match class: 0 1 P53365,Q16537 124 4.72e-02 8229 7 7 1.000 0.001 TF:M02089_1 tf 1 Factor: E2F-3; motif: GGCGGGN; match class: 1 1 Q13362,Q14738,P67775,Q13136,P53365,P30154,Q16537 124 4.74e-02 660 7 2 0.286 0.003 TF:M00373_1 tf 1 Factor: Pax-4; motif: NGNVGTCANGCGTGNNSNNYN; match class: 1 1 Q13362,Q14738 124 4.94e-02 594 7 2 0.286 0.003 MI:mmu-miR-466b-5p mi 1 MI:mmu-miR-466b-5p 1 P30154,Q16537 124 4.95e-02 1633 7 3 0.429 0.002 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 Q14738,P67775,Q13136 124 4.95e-02 2861 7 4 0.571 0.001 TF:M02095_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 Q13362,Q14738,P67775,P30154 124 5.00e-02 13 7 1 0.143 0.077 OMIM:211980 omi 1 LUNG CANCERALVEOLAR CELL CARCINOMA, INCLUDED;;ADENOCARCINOMA OF LUNG, INCLUDED;;NONSMALL CELL LUNG CANCER, INCLUDED;;LUNG CANCER, PROTECTION AGAINST, INCLUDED 1 P30154 124 5.00e-02 36 7 2 0.286 0.056 GO:1903293 CC 1 phosphatase complex 1 Q13362,P67775 124 5.00e-02 2 7 1 0.143 0.500 CORUM:1543 cor 1 PPP2CA-PPP2R1A complex 1 P67775 124 5.00e-02 36 7 2 0.286 0.056 GO:0008287 CC 1 protein serine/threonine phosphatase complex 1 Q13362,P67775 124 5.00e-02 128 7 2 0.286 0.016 KEGG:04390 keg 1 Hippo signaling pathway 1 P67775,P30154 124 5.00e-02 47 7 1 0.143 0.021 REAC:6811440 rea 1 Retrograde transport at the Trans-Golgi-Network 1 P53365 125 7.22e-07 7 2 2 1.000 0.286 GO:0005683 CC 1 U7 snRNP 1 P62306,P62308 125 1.55e-06 10 2 2 1.000 0.200 GO:0005687 CC 1 U4 snRNP 1 P62306,P62308 125 2.04e-06 10 2 2 1.000 0.200 REAC:111367 rea 1 SLBP independent Processing of Histone Pre-mRNAs 1 P62306,P62308 125 2.27e-06 12 2 2 1.000 0.167 GO:0034709 CC 1 methylosome 1 P62306,P62308 125 2.50e-06 11 2 2 1.000 0.182 REAC:77588 rea 1 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 1 P62306,P62308 125 3.61e-06 15 2 2 1.000 0.133 GO:0034719 CC 1 SMN-Sm protein complex 1 P62306,P62308 125 4.68e-06 17 2 2 1.000 0.118 GO:0005685 CC 1 U1 snRNP 1 P62306,P62308 125 9.49e-06 24 2 2 1.000 0.083 GO:0005689 CC 1 U12-type spliceosomal complex 1 P62306,P62308 125 1.30e-05 28 2 2 1.000 0.071 GO:0008334 BP 1 histone mRNA metabolic process 1 P62306,P62308 125 1.36e-05 25 2 2 1.000 0.080 REAC:75067 rea 1 Processing of Capped Intronless Pre-mRNA 1 P62306,P62308 125 1.52e-05 3 2 2 1.000 0.667 CORUM:1743 cor 1 (E.F.G) complex 1 P62306,P62308 125 2.17e-05 36 2 2 1.000 0.056 GO:0000387 BP 1 spliceosomal snRNP assembly 1 P62306,P62308 125 4.92e-05 54 2 2 1.000 0.037 GO:0097525 CC 1 spliceosomal snRNP complex 1 P62306,P62308 125 5.56e-05 50 2 2 1.000 0.040 REAC:191859 rea 1 snRNP Assembly 1 P62306,P62308 125 5.56e-05 50 2 2 1.000 0.040 REAC:194441 rea 1 Metabolism of non-coding RNA 1 P62306,P62308 125 5.79e-05 51 2 2 1.000 0.039 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 P62306,P62308 125 6.29e-05 61 2 2 1.000 0.033 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 P62306,P62308 125 6.71e-05 63 2 2 1.000 0.032 GO:0006369 BP 1 termination of RNA polymerase II transcription 1 P62306,P62308 125 8.30e-05 61 2 2 1.000 0.033 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 P62306,P62308 125 8.30e-05 61 2 2 1.000 0.033 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 P62306,P62308 125 1.06e-04 7 2 2 1.000 0.286 CORUM:2757 cor 1 SMN complex, U7 snRNA specific 1 P62306,P62308 125 1.29e-04 87 2 2 1.000 0.023 GO:0034708 CC 1 methyltransferase complex 1 P62306,P62308 125 1.32e-04 88 2 2 1.000 0.023 GO:0071013 CC 1 catalytic step 2 spliceosome 1 P62306,P62308 125 1.42e-04 8 2 2 1.000 0.250 CORUM:835 cor 1 6S methyltransferase and RG-containing Sm proteins complex 1 P62306,P62308 125 1.67e-04 99 2 2 1.000 0.020 GO:0006353 BP 1 DNA-templated transcription, termination 1 P62306,P62308 125 1.82e-04 9 2 2 1.000 0.222 CORUM:1142 cor 1 SMN complex 1 P62306,P62308 125 3.69e-04 147 2 2 1.000 0.014 GO:0005681 CC 1 spliceosomal complex 1 P62306,P62308 125 4.42e-04 140 2 2 1.000 0.014 REAC:73857 rea 1 RNA Polymerase II Transcription 1 P62306,P62308 125 4.61e-04 14 2 2 1.000 0.143 CORUM:1068 cor 1 12S U11 snRNP 1 P62306,P62308 125 5.11e-04 173 2 2 1.000 0.012 GO:0022618 BP 1 ribonucleoprotein complex assembly 1 P62306,P62308 125 5.32e-04 15 2 2 1.000 0.133 CORUM:1745 cor 1 SMN complex 1 P62306,P62308 125 5.32e-04 15 2 2 1.000 0.133 CORUM:1143 cor 1 SMN complex 1 P62306,P62308 125 5.66e-04 182 2 2 1.000 0.011 GO:0071826 BP 1 ribonucleoprotein complex subunit organization 1 P62306,P62308 125 5.79e-04 184 2 2 1.000 0.011 GO:0051170 BP 1 nuclear import 1 P62306,P62308 125 6.75e-04 173 2 2 1.000 0.012 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P62306,P62308 125 7.31e-04 180 2 2 1.000 0.011 REAC:72172 rea 1 mRNA Splicing 1 P62306,P62308 125 1.17e-03 228 2 2 1.000 0.009 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P62306,P62308 125 1.20e-03 265 2 2 1.000 0.008 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P62306,P62308 125 1.20e-03 265 2 2 1.000 0.008 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P62306,P62308 125 1.24e-03 269 2 2 1.000 0.007 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P62306,P62308 125 1.28e-03 23 2 2 1.000 0.087 CORUM:430 cor 1 18S U11/U12 snRNP 1 P62306,P62308 125 1.73e-03 318 2 2 1.000 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 P62306,P62308 125 1.80e-03 324 2 2 1.000 0.006 GO:0051169 BP 1 nuclear transport 1 P62306,P62308 125 1.82e-03 326 2 2 1.000 0.006 GO:0008380 BP 1 RNA splicing 1 P62306,P62308 125 2.00e-03 342 2 2 1.000 0.006 GO:0006397 BP 1 mRNA processing 1 P62306,P62308 125 2.04e-03 13 2 1 0.500 0.077 TF:M06420_0 tf 1 Factor: ZNF493; motif: NTGGTYGGCAGA; match class: 0 1 P62306 125 2.38e-03 6 2 1 0.500 0.167 GO:0034715 CC 1 pICln-Sm protein complex 1 P62306 125 2.66e-03 394 2 2 1.000 0.005 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 P62306,P62308 125 2.67e-03 17 2 1 0.500 0.059 TF:M06774_0 tf 1 Factor: ZNF629; motif: NWAATAAGMATA; match class: 0 1 P62306 125 2.67e-03 33 2 2 1.000 0.061 CORUM:2755 cor 1 17S U2 snRNP 1 P62306,P62308 125 4.67e-03 522 2 2 1.000 0.004 GO:0016071 BP 1 mRNA metabolic process 1 P62306,P62308 125 5.15e-03 13 2 1 0.500 0.077 GO:0045495 CC 1 pole plasm 1 P62308 125 5.15e-03 13 2 1 0.500 0.077 GO:0060293 CC 1 germ plasm 1 P62308 125 5.15e-03 13 2 1 0.500 0.077 GO:0043186 CC 1 P granule 1 P62308 125 5.94e-03 15 2 1 0.500 0.067 GO:0071004 CC 1 U2-type prespliceosome 1 P62308 125 6.16e-03 599 2 2 1.000 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P62306,P62308 125 6.18e-03 600 2 2 1.000 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 P62306,P62308 125 6.34e-03 16 2 1 0.500 0.062 GO:0005682 CC 1 U5 snRNP 1 P62308 125 6.68e-03 624 2 2 1.000 0.003 GO:1990234 CC 1 transferase complex 1 P62306,P62308 125 7.00e-03 1065 2 2 1.000 0.002 TF:M01971_0 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 0 1 P62306,P62308 125 7.53e-03 19 2 1 0.500 0.053 GO:0005686 CC 1 U2 snRNP 1 P62308 125 8.15e-03 689 2 2 1.000 0.003 GO:0034622 BP 1 cellular macromolecular complex assembly 1 P62306,P62308 125 8.32e-03 21 2 1 0.500 0.048 GO:0071010 CC 1 prespliceosome 1 P62308 125 9.71e-03 752 2 2 1.000 0.003 GO:0006396 BP 1 RNA processing 1 P62306,P62308 125 9.90e-03 25 2 1 0.500 0.040 GO:0071011 CC 1 precatalytic spliceosome 1 P62308 125 1.07e-02 68 2 1 0.500 0.015 TF:M07223_1 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 1 1 P62308 125 1.07e-02 27 2 1 0.500 0.037 GO:0097526 CC 1 spliceosomal tri-snRNP complex 1 P62308 125 1.08e-02 1323 2 2 1.000 0.002 TF:M00489_1 tf 1 Factor: Nkx6-2; motif: NWADTAAWTANN; match class: 1 1 P62306,P62308 125 1.22e-02 78 2 1 0.500 0.013 TF:M02073_1 tf 1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 1 P62308 125 1.23e-02 31 2 1 0.500 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 P62308 125 1.48e-02 1547 2 2 1.000 0.001 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 P62306,P62308 125 1.48e-02 1547 2 2 1.000 0.001 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 P62306,P62308 125 1.56e-02 79 2 2 1.000 0.025 CORUM:1181 cor 1 C complex spliceosome 1 P62306,P62308 125 1.58e-02 1598 2 2 1.000 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 P62306,P62308 125 1.58e-02 101 2 1 0.500 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 P62306 125 1.82e-02 46 2 1 0.500 0.022 GO:0000245 BP 1 spliceosomal complex assembly 1 P62308 125 1.83e-02 117 2 1 0.500 0.009 TF:M00528_1 tf 1 Factor: PPAR; motif: WASNRGGNCAAAGGTCA; match class: 1 1 P62306 125 1.83e-02 1033 2 2 1.000 0.002 GO:1902494 CC 1 catalytic complex 1 P62306,P62308 125 1.94e-02 1775 2 2 1.000 0.001 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 P62306,P62308 125 2.03e-02 130 2 1 0.500 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 P62308 125 2.09e-02 134 2 1 0.500 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 P62306 125 2.11e-02 135 2 1 0.500 0.007 TF:M05362_0 tf 1 Factor: NKX1-1; motif: WTAATAWGGA; match class: 0 1 P62306 125 2.13e-02 1113 2 2 1.000 0.002 GO:0065003 BP 1 macromolecular complex assembly 1 P62306,P62308 125 2.27e-02 1916 2 2 1.000 0.001 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 P62306,P62308 125 2.27e-02 1920 2 2 1.000 0.001 TF:M00145_0 tf 1 Factor: Brn-2; motif: NNCATNSRWAATNMRN; match class: 0 1 P62306,P62308 125 2.38e-02 1177 2 2 1.000 0.002 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 P62306,P62308 125 2.39e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 P62306 125 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 P62306 125 2.63e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 P62306,P62308 125 2.64e-02 169 2 1 0.500 0.006 TF:M04085_1 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 1 1 P62308 125 2.79e-02 179 2 1 0.500 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 P62306 125 2.84e-02 182 2 1 0.500 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 P62306 125 3.00e-02 2204 2 2 1.000 0.001 TF:M01107_1 tf 1 Factor: RUSH-1alpha; motif: NNMCWTNKNN; match class: 1 1 P62306,P62308 125 3.07e-02 1336 2 2 1.000 0.001 GO:0003723 MF 1 RNA binding 1 P62306,P62308 125 3.09e-02 2238 2 2 1.000 0.001 TF:M00918_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 P62306,P62308 125 3.23e-02 2288 2 2 1.000 0.001 TF:M00919_0 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 0 1 P62306,P62308 125 3.37e-02 216 2 1 0.500 0.005 TF:M02062_1 tf 1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 1 P62308 125 3.74e-02 2462 2 2 1.000 0.001 TF:M00939_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 P62306,P62308 125 3.83e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 P62306,P62308 125 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 P62306 125 4.24e-02 273 2 1 0.500 0.004 TF:M05501_0 tf 1 Factor: ZBTB8B; motif: NRGGGGATAGN; match class: 0 1 P62308 125 4.44e-02 286 2 1 0.500 0.003 TF:M04414_1 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 1 1 P62306 125 4.48e-02 1614 2 2 1.000 0.001 GO:0043933 BP 1 macromolecular complex subunit organization 1 P62306,P62308 125 4.50e-02 114 2 1 0.500 0.009 GO:0036464 CC 1 cytoplasmic ribonucleoprotein granule 1 P62308 125 4.54e-02 292 2 1 0.500 0.003 TF:M05837_0 tf 1 Factor: ZFP2; motif: NCCWCGGGRATA; match class: 0 1 P62308 125 4.73e-02 120 2 1 0.500 0.008 GO:0035770 CC 1 ribonucleoprotein granule 1 P62308 125 4.85e-02 265 2 1 0.500 0.004 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 P62308 125 4.89e-02 2816 2 2 1.000 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 P62306,P62308 125 4.97e-02 320 2 1 0.500 0.003 TF:M06344_0 tf 1 Factor: ZNF530; motif: NGGGCAATWAYA; match class: 0 1 P62308 125 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 P62306 125 4.98e-02 321 2 1 0.500 0.003 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 P62306 125 5.00e-02 141 2 2 1.000 0.014 CORUM:351 cor 1 Spliceosome 1 P62306,P62308 125 5.00e-02 1706 2 2 1.000 0.001 GO:0022607 BP 1 cellular component assembly 1 P62306,P62308 125 5.00e-02 128 2 2 1.000 0.016 KEGG:03040 keg 1 Spliceosome 1 P62306,P62308 125 5.00e-02 1485 2 2 1.000 0.001 REAC:74160 rea 1 Gene Expression 1 P62306,P62308 126 7.01e-08 21 4 3 0.750 0.143 GO:0016538 MF 1 cyclin-dependent protein serine/threonine kinase regulator activity 1 P42773,P11802,Q8N726 126 7.10e-07 30 4 3 0.750 0.100 REAC:2559585 rea 1 Oncogene Induced Senescence 1 P42773,P11802,Q8N726 126 1.36e-06 37 4 3 0.750 0.081 REAC:69236 rea 1 G1 Phase 1 P42773,P11802,Q8N726 126 1.36e-06 37 4 3 0.750 0.081 REAC:69231 rea 1 Cyclin D associated events in G1 1 P42773,P11802,Q8N726 126 5.38e-06 58 4 3 0.750 0.052 REAC:2559582 rea 1 Senescence-Associated Secretory Phenotype (SASP) 1 P42773,P11802,Q8N726 126 1.09e-05 9 4 2 0.500 0.222 GO:0004861 MF 1 cyclin-dependent protein serine/threonine kinase inhibitor activity 1 P42773,Q8N726 126 1.18e-05 75 4 3 0.750 0.040 REAC:2559580 rea 1 Oxidative Stress Induced Senescence 1 P42773,P11802,Q8N726 126 1.19e-05 112 4 3 0.750 0.027 GO:0019887 MF 1 protein kinase regulator activity 1 P42773,P11802,Q8N726 126 1.62e-05 124 4 3 0.750 0.024 GO:0019207 MF 1 kinase regulator activity 1 P42773,P11802,Q8N726 126 4.29e-05 87 4 3 0.750 0.034 KEGG:01522 keg 1 Endocrine resistance 1 P42773,P11802,Q8N726 126 4.82e-05 178 4 3 0.750 0.017 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P42773,P11802,Q8N726 126 4.90e-05 3 4 2 0.500 0.667 CORUM:1642 cor 1 p16-cyclin D2-CDK4 complex 1 P11802,Q8N726 126 4.98e-05 180 4 3 0.750 0.017 GO:0007050 BP 1 cell cycle arrest 1 P42773,P11802,Q8N726 126 5.41e-05 185 4 3 0.750 0.016 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P42773,P11802,Q8N726 126 5.66e-05 7 4 2 0.500 0.286 OMIM:155600 omi 1 Susceptibility to Cutaneous Malignant Melanoma 1 P11802,Q8N726 126 7.01e-05 22 4 2 0.500 0.091 GO:0030291 MF 1 protein serine/threonine kinase inhibitor activity 1 P42773,Q8N726 126 7.41e-05 138 4 3 0.750 0.022 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P42773,P11802,Q8N726 126 7.41e-05 138 4 3 0.750 0.022 REAC:2559583 rea 1 Cellular Senescence 1 P42773,P11802,Q8N726 126 9.15e-05 48 4 3 0.750 0.062 HP:0002894 hp 1 Neoplasm of the pancreas 1 P42773,P11802,Q8N726 126 1.05e-04 117 4 3 0.750 0.026 KEGG:04110 keg 1 Cell cycle 1 P42773,P11802,Q8N726 126 1.51e-04 7 4 2 0.500 0.286 HP:0001062 hp 1 Atypical nevus 1 P11802,Q8N726 126 1.51e-04 7 4 2 0.500 0.286 HP:0001074 hp 1 Atypical nevi in non-sun exposed areas 1 P11802,Q8N726 126 1.60e-04 33 4 2 0.500 0.061 GO:0010389 BP 1 regulation of G2/M transition of mitotic cell cycle 1 P11802,Q8N726 126 2.01e-04 8 4 2 0.500 0.250 HP:0007716 hp 1 Intraocular melanoma 1 P11802,Q8N726 126 2.24e-04 39 4 2 0.500 0.051 GO:1902749 BP 1 regulation of cell cycle G2/M phase transition 1 P11802,Q8N726 126 3.94e-04 11 4 2 0.500 0.182 HP:0100012 hp 1 Neoplasm of the eye 1 P11802,Q8N726 126 4.52e-04 376 4 3 0.750 0.008 GO:0045786 BP 1 negative regulation of cell cycle 1 P42773,P11802,Q8N726 126 5.53e-04 61 4 2 0.500 0.033 GO:0004860 MF 1 protein kinase inhibitor activity 1 P42773,Q8N726 126 5.58e-04 13 4 2 0.500 0.154 HP:0012056 hp 1 Cutaneous melanoma 1 P11802,Q8N726 126 5.58e-04 13 4 2 0.500 0.154 HP:0001054 hp 1 Numerous nevi 1 P11802,Q8N726 126 5.71e-04 62 4 2 0.500 0.032 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 P42773,Q8N726 126 5.71e-04 62 4 2 0.500 0.032 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 P42773,Q8N726 126 5.90e-04 411 4 3 0.750 0.007 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P42773,P11802,Q8N726 126 5.90e-04 63 4 2 0.500 0.032 GO:0019210 MF 1 kinase inhibitor activity 1 P42773,Q8N726 126 6.47e-04 36 4 2 0.500 0.056 KEGG:05219 keg 1 Bladder cancer 1 P11802,Q8N726 126 6.52e-04 425 4 3 0.750 0.007 GO:0044770 BP 1 cell cycle phase transition 1 P42773,P11802,Q8N726 126 6.75e-04 218 4 3 0.750 0.014 KEGG:05166 keg 1 HTLV-I infection 1 P42773,P11802,Q8N726 126 1.17e-03 1 4 1 0.250 1.000 GO:0034393 BP 1 positive regulation of smooth muscle cell apoptotic process 1 Q8N726 126 1.36e-03 52 4 2 0.500 0.038 KEGG:05223 keg 1 Non-small cell lung cancer 1 P11802,Q8N726 126 1.46e-03 54 4 2 0.500 0.037 KEGG:05218 keg 1 Melanoma 1 P11802,Q8N726 126 1.49e-03 100 4 2 0.500 0.020 GO:0030308 BP 1 negative regulation of cell growth 1 P42773,Q8N726 126 1.50e-03 378 4 3 0.750 0.008 REAC:2262752 rea 1 Cellular responses to stress 1 P42773,P11802,Q8N726 126 1.57e-03 56 4 2 0.500 0.036 KEGG:04115 keg 1 p53 signaling pathway 1 P11802,Q8N726 126 1.61e-03 124 4 3 0.750 0.024 HP:0100242 hp 1 Sarcoma 1 P42773,P11802,Q8N726 126 1.63e-03 57 4 2 0.500 0.035 KEGG:05214 keg 1 Glioma 1 P11802,Q8N726 126 1.65e-03 125 4 3 0.750 0.024 HP:0008069 hp 1 Neoplasm of the skin 1 P42773,P11802,Q8N726 126 1.66e-03 582 4 3 0.750 0.005 GO:0030234 MF 1 enzyme regulator activity 1 P42773,P11802,Q8N726 126 1.87e-03 61 4 2 0.500 0.033 KEGG:05212 keg 1 Pancreatic cancer 1 P11802,Q8N726 126 2.21e-03 122 4 2 0.500 0.016 GO:0045926 BP 1 negative regulation of growth 1 P42773,Q8N726 126 2.26e-03 139 4 3 0.750 0.022 HP:0007378 hp 1 Neoplasm of the gastrointestinal tract 1 P42773,P11802,Q8N726 126 2.30e-03 1 4 1 0.250 1.000 OMIM:155601 omi 1 MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2; CMM2 1 Q8N726 126 2.30e-03 1 4 1 0.250 1.000 OMIM:606719 omi 1 MELANOMA-PANCREATIC CANCER SYNDROME;;FAMILIAL ATYPICAL MULTIPLE MOLE MELANOMA-PANCREATIC CARCINOMA SYNDROME;FAMMMPC 1 Q8N726 126 2.30e-03 1 4 1 0.250 1.000 OMIM:155755 omi 1 MELANOMA-ASTROCYTOMA SYNDROME;;MELANOMA AND NEURAL SYSTEM TUMOR SYNDROME 1 Q8N726 126 2.30e-03 1 4 1 0.250 1.000 OMIM:609048 omi 1 MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3; CMM3 1 P11802 126 2.31e-03 26 4 2 0.500 0.077 HP:0002861 hp 1 Melanoma 1 P11802,Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0055105 MF 1 ubiquitin-protein transferase inhibitor activity 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033080 BP 1 immature T cell proliferation in thymus 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033084 BP 1 regulation of immature T cell proliferation in thymus 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033087 BP 1 negative regulation of immature T cell proliferation 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0035985 CC 1 senescence-associated heterochromatin focus 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0035986 BP 1 senescence-associated heterochromatin focus assembly 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033083 BP 1 regulation of immature T cell proliferation 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033088 BP 1 negative regulation of immature T cell proliferation in thymus 1 Q8N726 126 2.34e-03 2 4 1 0.250 0.500 GO:0033079 BP 1 immature T cell proliferation 1 Q8N726 126 2.38e-03 657 4 3 0.750 0.005 GO:1903047 BP 1 mitotic cell cycle process 1 P42773,P11802,Q8N726 126 2.39e-03 69 4 2 0.500 0.029 KEGG:05220 keg 1 Chronic myeloid leukemia 1 P11802,Q8N726 126 2.49e-03 448 4 3 0.750 0.007 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P42773,P11802,Q8N726 126 2.54e-03 672 4 3 0.750 0.004 GO:0042127 BP 1 regulation of cell proliferation 1 P42773,P11802,Q8N726 126 2.62e-03 679 4 3 0.750 0.004 GO:0051726 BP 1 regulation of cell cycle 1 P42773,P11802,Q8N726 126 2.69e-03 28 4 2 0.500 0.071 HP:0001480 hp 1 Freckling 1 P11802,Q8N726 126 3.13e-03 721 4 3 0.750 0.004 GO:0000278 BP 1 mitotic cell cycle 1 P42773,P11802,Q8N726 126 3.51e-03 3 4 1 0.250 0.333 GO:0034391 BP 1 regulation of smooth muscle cell apoptotic process 1 Q8N726 126 3.51e-03 3 4 1 0.250 0.333 GO:0034390 BP 1 smooth muscle cell apoptotic process 1 Q8N726 126 3.51e-03 3 4 1 0.250 0.333 GO:2000111 BP 1 positive regulation of macrophage apoptotic process 1 Q8N726 126 3.52e-03 154 4 2 0.500 0.013 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 P11802,Q8N726 126 3.85e-03 161 4 2 0.500 0.012 GO:0044839 BP 1 cell cycle G2/M phase transition 1 P11802,Q8N726 126 3.97e-03 168 4 3 0.750 0.018 HP:0001732 hp 1 Abnormality of the pancreas 1 P42773,P11802,Q8N726 126 4.49e-03 547 4 3 0.750 0.005 REAC:1640170 rea 1 Cell Cycle 1 P42773,P11802,Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:0033085 BP 1 negative regulation of T cell differentiation in thymus 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:0033034 BP 1 positive regulation of myeloid cell apoptotic process 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:0010661 BP 1 positive regulation of muscle cell apoptotic process 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:0030889 BP 1 negative regulation of B cell proliferation 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:1903624 BP 1 regulation of DNA catabolic process 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:2000399 BP 1 negative regulation of thymocyte aggregation 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:1902510 BP 1 regulation of apoptotic DNA fragmentation 1 Q8N726 126 4.67e-03 4 4 1 0.250 0.250 GO:2000774 BP 1 positive regulation of cellular senescence 1 Q8N726 126 4.70e-03 828 4 3 0.750 0.004 GO:0098772 MF 1 molecular function regulator 1 P42773,P11802,Q8N726 126 5.84e-03 5 4 1 0.250 0.200 GO:0090343 BP 1 positive regulation of cell aging 1 Q8N726 126 5.84e-03 5 4 1 0.250 0.200 GO:2000109 BP 1 regulation of macrophage apoptotic process 1 Q8N726 126 6.13e-03 906 4 3 0.750 0.003 GO:0008283 BP 1 cell proliferation 1 P42773,P11802,Q8N726 126 6.36e-03 197 4 3 0.750 0.015 HP:0011792 hp 1 Neoplasm by histology 1 P42773,P11802,Q8N726 126 6.44e-03 1 4 1 0.250 1.000 HP:0012142 hp 1 Pancreatic squamous cell carcinoma 1 Q8N726 126 6.44e-03 1 4 1 0.250 1.000 HP:0012182 hp 1 Oropharyngeal squamous cell carcinoma 1 Q8N726 126 6.95e-03 217 4 2 0.500 0.009 GO:0004857 MF 1 enzyme inhibitor activity 1 P42773,Q8N726 126 7.01e-03 6 4 1 0.250 0.167 GO:0071888 BP 1 macrophage apoptotic process 1 Q8N726 126 7.09e-03 952 4 3 0.750 0.003 GO:0022402 BP 1 cell cycle process 1 P42773,P11802,Q8N726 126 7.27e-03 222 4 2 0.500 0.009 GO:0001558 BP 1 regulation of cell growth 1 P42773,Q8N726 126 7.62e-03 5 4 1 0.250 0.200 REAC:8849470 rea 1 PTK6 Regulates Cell Cycle 1 P11802 126 8.07e-03 234 4 2 0.500 0.009 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 P11802,Q8N726 126 8.18e-03 7 4 1 0.250 0.143 GO:0031507 BP 1 heterochromatin assembly 1 Q8N726 126 8.18e-03 7 4 1 0.250 0.143 GO:0006925 BP 1 inflammatory cell apoptotic process 1 Q8N726 126 8.69e-03 243 4 2 0.500 0.008 GO:1901987 BP 1 regulation of cell cycle phase transition 1 P11802,Q8N726 126 8.91e-03 246 4 2 0.500 0.008 GO:0042326 BP 1 negative regulation of phosphorylation 1 P42773,Q8N726 126 8.95e-03 51 4 2 0.500 0.039 HP:0100013 hp 1 Neoplasm of the breast 1 P11802,Q8N726 126 9.31e-03 52 4 2 0.500 0.038 HP:0010566 hp 1 Hamartoma 1 P11802,Q8N726 126 9.34e-03 8 4 1 0.250 0.125 GO:0090399 BP 1 replicative senescence 1 Q8N726 126 9.34e-03 8 4 1 0.250 0.125 GO:0033032 BP 1 regulation of myeloid cell apoptotic process 1 Q8N726 126 9.34e-03 8 4 1 0.250 0.125 GO:0055106 MF 1 ubiquitin-protein transferase regulator activity 1 Q8N726 126 9.94e-03 1068 4 3 0.750 0.003 GO:0006468 BP 1 protein phosphorylation 1 P42773,P11802,Q8N726 126 1.05e-02 9 4 1 0.250 0.111 GO:0050869 BP 1 negative regulation of B cell activation 1 Q8N726 126 1.12e-02 276 4 2 0.500 0.007 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 P42773,Q8N726 126 1.15e-02 280 4 2 0.500 0.007 GO:0016049 BP 1 cell growth 1 P42773,Q8N726 126 1.17e-02 1128 4 3 0.750 0.003 GO:0007049 BP 1 cell cycle 1 P42773,P11802,Q8N726 126 1.17e-02 282 4 2 0.500 0.007 GO:0040008 BP 1 regulation of growth 1 P42773,Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0033028 BP 1 myeloid cell apoptotic process 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:2000398 BP 1 regulation of thymocyte aggregation 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0070828 BP 1 heterochromatin organization 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0045581 BP 1 negative regulation of T cell differentiation 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0033081 BP 1 regulation of T cell differentiation in thymus 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0033235 BP 1 positive regulation of protein sumoylation 1 Q8N726 126 1.17e-02 10 4 1 0.250 0.100 GO:0010971 BP 1 positive regulation of G2/M transition of mitotic cell cycle 1 P11802 126 1.21e-02 245 4 3 0.750 0.012 HP:0002577 hp 1 Abnormality of the stomach 1 P42773,P11802,Q8N726 126 1.22e-02 289 4 2 0.500 0.007 GO:0008285 BP 1 negative regulation of cell proliferation 1 P42773,Q8N726 126 1.27e-02 294 4 2 0.500 0.007 GO:0000785 CC 1 chromatin 1 P11802,Q8N726 126 1.28e-02 11 4 1 0.250 0.091 GO:1902751 BP 1 positive regulation of cell cycle G2/M phase transition 1 P11802 126 1.28e-02 11 4 1 0.250 0.091 GO:0048103 BP 1 somatic stem cell division 1 Q8N726 126 1.29e-02 2 4 1 0.250 0.500 HP:0006725 hp 1 Pancreatic adenocarcinoma 1 Q8N726 126 1.29e-02 162 4 2 0.500 0.012 KEGG:05203 keg 1 Viral carcinogenesis 1 P11802,Q8N726 126 1.36e-02 63 4 2 0.500 0.032 HP:0003764 hp 1 Nevus 1 P11802,Q8N726 126 1.40e-02 12 4 1 0.250 0.083 GO:0010657 BP 1 muscle cell apoptotic process 1 Q8N726 126 1.40e-02 12 4 1 0.250 0.083 GO:0010660 BP 1 regulation of muscle cell apoptotic process 1 Q8N726 126 1.51e-02 322 4 2 0.500 0.006 GO:0045936 BP 1 negative regulation of phosphate metabolic process 1 P42773,Q8N726 126 1.52e-02 13 4 1 0.250 0.077 GO:0071157 BP 1 negative regulation of cell cycle arrest 1 P11802 126 1.52e-02 13 4 1 0.250 0.077 GO:2000108 BP 1 positive regulation of leukocyte apoptotic process 1 Q8N726 126 1.52e-02 13 4 1 0.250 0.077 GO:0042130 BP 1 negative regulation of T cell proliferation 1 Q8N726 126 1.52e-02 13 4 1 0.250 0.077 GO:0045620 BP 1 negative regulation of lymphocyte differentiation 1 Q8N726 126 1.52e-02 323 4 2 0.500 0.006 GO:0010563 BP 1 negative regulation of phosphorus metabolic process 1 P42773,Q8N726 126 1.63e-02 1266 4 3 0.750 0.002 GO:0016310 BP 1 phosphorylation 1 P42773,P11802,Q8N726 126 1.63e-02 14 4 1 0.250 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 P11802 126 1.63e-02 14 4 1 0.250 0.071 GO:0030332 MF 1 cyclin binding 1 P11802 126 1.63e-02 14 4 1 0.250 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 P11802 126 1.63e-02 14 4 1 0.250 0.071 GO:0019789 MF 1 SUMO transferase activity 1 Q8N726 126 1.63e-02 14 4 1 0.250 0.071 GO:0045736 BP 1 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1 Q8N726 126 1.63e-02 14 4 1 0.250 0.071 GO:1904030 BP 1 negative regulation of cyclin-dependent protein kinase activity 1 Q8N726 126 1.68e-02 339 4 2 0.500 0.006 GO:0019901 MF 1 protein kinase binding 1 P42773,Q8N726 126 1.73e-02 71 4 2 0.500 0.028 HP:0006753 hp 1 Neoplasm of the stomach 1 P11802,Q8N726 126 1.75e-02 15 4 1 0.250 0.067 GO:0017145 BP 1 stem cell division 1 Q8N726 126 1.75e-02 15 4 1 0.250 0.067 GO:2000772 BP 1 regulation of cellular senescence 1 Q8N726 126 1.75e-02 15 4 1 0.250 0.067 GO:0050672 BP 1 negative regulation of lymphocyte proliferation 1 Q8N726 126 1.75e-02 15 4 1 0.250 0.067 GO:0032945 BP 1 negative regulation of mononuclear cell proliferation 1 Q8N726 126 1.87e-02 16 4 1 0.250 0.062 GO:0033233 BP 1 regulation of protein sumoylation 1 Q8N726 126 1.87e-02 16 4 1 0.250 0.062 GO:0006309 BP 1 apoptotic DNA fragmentation 1 Q8N726 126 1.92e-02 363 4 2 0.500 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 P11802,Q8N726 126 1.97e-02 368 4 2 0.500 0.005 GO:0040007 BP 1 growth 1 P42773,Q8N726 126 1.98e-02 17 4 1 0.250 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 Q8N726 126 2.10e-02 18 4 1 0.250 0.056 GO:0030888 BP 1 regulation of B cell proliferation 1 Q8N726 126 2.10e-02 18 4 1 0.250 0.056 GO:1900117 BP 1 regulation of execution phase of apoptosis 1 Q8N726 126 2.16e-02 386 4 2 0.500 0.005 GO:0019900 MF 1 kinase binding 1 P42773,Q8N726 126 2.22e-02 19 4 1 0.250 0.053 GO:0090342 BP 1 regulation of cell aging 1 Q8N726 126 2.22e-02 19 4 1 0.250 0.053 GO:0000737 BP 1 DNA catabolic process, endonucleolytic 1 Q8N726 126 2.33e-02 20 4 1 0.250 0.050 GO:0033077 BP 1 T cell differentiation in thymus 1 Q8N726 126 2.33e-02 20 4 1 0.250 0.050 GO:0071594 BP 1 thymocyte aggregation 1 Q8N726 126 2.33e-02 20 4 1 0.250 0.050 GO:0001953 BP 1 negative regulation of cell-matrix adhesion 1 Q8N726 126 2.34e-02 402 4 2 0.500 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 P11802,Q8N726 126 2.34e-02 402 4 2 0.500 0.005 GO:0045859 BP 1 regulation of protein kinase activity 1 P42773,Q8N726 126 2.34e-02 307 4 3 0.750 0.010 HP:0001000 hp 1 Abnormality of skin pigmentation 1 P42773,P11802,Q8N726 126 2.45e-02 21 4 1 0.250 0.048 GO:0030262 BP 1 apoptotic nuclear changes 1 Q8N726 126 2.50e-02 2 4 1 0.250 0.500 CORUM:3085 cor 1 CCND2-CDK4 complex 1 P11802 126 2.50e-02 2 4 1 0.250 0.500 CORUM:3084 cor 1 CCND1-CDK4 complex 1 P11802 126 2.50e-02 2 4 1 0.250 0.500 CORUM:5107 cor 1 p34(SEI-1)-CDK4-CyclinD2 complex 1 P11802 126 2.50e-02 2 4 1 0.250 0.500 CORUM:5287 cor 1 CDK4-CCND1 complex 1 P11802 126 2.50e-02 2 4 1 0.250 0.500 CORUM:3086 cor 1 CCND3-CDK4 complex 1 P11802 126 2.57e-02 22 4 1 0.250 0.045 GO:0031648 BP 1 protein destabilization 1 Q8N726 126 2.57e-02 22 4 1 0.250 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 P11802 126 2.58e-02 17 4 1 0.250 0.059 REAC:3232118 rea 1 SUMOylation of transcription factors 1 Q8N726 126 2.68e-02 23 4 1 0.250 0.043 GO:0051059 MF 1 NF-kappaB binding 1 Q8N726 126 2.68e-02 23 4 1 0.250 0.043 GO:0006308 BP 1 DNA catabolic process 1 Q8N726 126 2.78e-02 439 4 2 0.500 0.005 GO:0043549 BP 1 regulation of kinase activity 1 P42773,Q8N726 126 2.91e-02 25 4 1 0.250 0.040 GO:0050868 BP 1 negative regulation of T cell activation 1 Q8N726 126 2.91e-02 25 4 1 0.250 0.040 GO:1902106 BP 1 negative regulation of leukocyte differentiation 1 Q8N726 126 3.07e-02 95 4 2 0.500 0.021 HP:0000488 hp 1 Retinopathy 1 P11802,Q8N726 126 3.15e-02 27 4 1 0.250 0.037 GO:1903038 BP 1 negative regulation of leukocyte cell-cell adhesion 1 Q8N726 126 3.21e-02 5 4 1 0.250 0.200 HP:0007449 hp 1 Confetti-like hypopigmented macules 1 P42773 126 3.21e-02 5 4 1 0.250 0.200 HP:0012197 hp 1 Insulinoma 1 P42773 126 3.21e-02 5 4 1 0.250 0.200 HP:0100633 hp 1 Esophagitis 1 P42773 126 3.21e-02 5 4 1 0.250 0.200 HP:0030404 hp 1 Glucagonoma 1 P42773 126 3.21e-02 5 4 1 0.250 0.200 HP:0008261 hp 1 Pancreatic islet cell adenoma 1 P42773 126 3.21e-02 5 4 1 0.250 0.200 HP:0030405 hp 1 Pancreatic endocrine tumor 1 P42773 126 3.38e-02 29 4 1 0.250 0.034 GO:0042100 BP 1 B cell proliferation 1 Q8N726 126 3.49e-02 30 4 1 0.250 0.033 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 P11802 126 3.61e-02 31 4 1 0.250 0.032 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 P11802 126 3.61e-02 31 4 1 0.250 0.032 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 Q8N726 126 3.75e-02 3 4 1 0.250 0.333 CORUM:220 cor 1 ARF-Mule complex 1 Q8N726 126 3.75e-02 3 4 1 0.250 0.333 CORUM:5100 cor 1 CyclinD3-CDK4-CDK6 complex 1 P11802 126 3.75e-02 3 4 1 0.250 0.333 CORUM:1633 cor 1 CyclinD1-CDK4-CDK6 complex 1 P11802 126 3.84e-02 33 4 1 0.250 0.030 GO:0090398 BP 1 cellular senescence 1 Q8N726 126 3.84e-02 33 4 1 0.250 0.030 GO:0051250 BP 1 negative regulation of lymphocyte activation 1 Q8N726 126 3.85e-02 6 4 1 0.250 0.167 HP:0008256 hp 1 Adrenocortical adenoma 1 P42773 126 3.85e-02 6 4 1 0.250 0.167 HP:0100570 hp 1 Carcinoid tumor 1 P42773 126 3.85e-02 6 4 1 0.250 0.167 HP:0002044 hp 1 Zollinger-Ellison syndrome 1 P42773 126 3.96e-02 34 4 1 0.250 0.029 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 P11802 126 4.01e-02 109 4 2 0.500 0.018 HP:0000958 hp 1 Dry skin 1 P11802,Q8N726 126 4.19e-02 36 4 1 0.250 0.028 GO:0045580 BP 1 regulation of T cell differentiation 1 Q8N726 126 4.19e-02 36 4 1 0.250 0.028 GO:2000106 BP 1 regulation of leukocyte apoptotic process 1 Q8N726 126 4.31e-02 37 4 1 0.250 0.027 GO:0002695 BP 1 negative regulation of leukocyte activation 1 Q8N726 126 4.31e-02 37 4 1 0.250 0.027 GO:0048145 BP 1 regulation of fibroblast proliferation 1 P11802 126 4.42e-02 38 4 1 0.250 0.026 GO:0050864 BP 1 regulation of B cell activation 1 Q8N726 126 4.42e-02 38 4 1 0.250 0.026 GO:0070534 BP 1 protein K63-linked ubiquitination 1 Q8N726 126 4.42e-02 38 4 1 0.250 0.026 GO:0048144 BP 1 fibroblast proliferation 1 P11802 126 4.49e-02 7 4 1 0.250 0.143 HP:0006767 hp 1 Pituitary prolactin cell adenoma 1 P42773 126 4.54e-02 565 4 2 0.500 0.004 GO:0044427 CC 1 chromosomal part 1 P11802,Q8N726 126 4.54e-02 39 4 1 0.250 0.026 GO:0006921 BP 1 cellular component disassembly involved in execution phase of apoptosis 1 Q8N726 126 4.54e-02 39 4 1 0.250 0.026 GO:0000792 CC 1 heterochromatin 1 Q8N726 126 4.72e-02 577 4 2 0.500 0.003 GO:0051338 BP 1 regulation of transferase activity 1 P42773,Q8N726 126 4.85e-02 32 4 1 0.250 0.031 REAC:6804757 rea 1 Regulation of TP53 Degradation 1 Q8N726 126 4.90e-02 1851 4 3 0.750 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P42773,P11802,Q8N726 126 5.00e-02 43 4 1 0.250 0.023 GO:0071887 BP 1 leukocyte apoptotic process 1 Q8N726 126 5.00e-02 22 4 1 0.250 0.045 OMIM:260350 omi 1 Pancreatic Cancer 1 Q8N726 126 5.00e-02 4 4 1 0.250 0.250 CORUM:5101 cor 1 CyclinD3-CDK4-CDK6-p21 complex 1 P11802 126 5.00e-02 509 4 3 0.750 0.006 MI:hsa-miR-885-3p mi 1 MI:hsa-miR-885-3p 1 P42773,P11802,Q8N726 126 5.00e-02 4 4 1 0.250 0.250 CORUM:312 cor 1 Cell cycle kinase complex CDK4 1 P11802 126 5.00e-02 122 4 2 0.500 0.016 HP:0004375 hp 1 Neoplasm of the nervous system 1 P42773,Q8N726 126 5.00e-02 33 4 1 0.250 0.030 REAC:6806003 rea 1 Regulation of TP53 Expression and Degradation 1 Q8N726 126 5.00e-02 325 4 2 0.500 0.006 KEGG:05200 keg 1 Pathways in cancer 1 P11802,Q8N726 126 5.00e-02 288 4 3 0.750 0.010 TF:M01209_1 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 1 1 Q5TC84,P11802,Q8N726 127 1.81e-03 69 4 2 0.500 0.029 GO:0008135 MF 1 translation factor activity, RNA binding 1 P46199,Q96RP9 127 1.88e-03 1 4 1 0.250 1.000 OMIM:615300 omi 1 PERRAULT SYNDROME 4; PRLTS4 1 Q15031 127 1.96e-03 90 4 2 0.500 0.022 REAC:5368287 rea 1 Mitochondrial translation 1 P46199,Q96RP9 127 2.44e-03 483 4 3 0.750 0.006 GO:0006412 BP 1 translation 1 Q15031,P46199,Q96RP9 127 2.67e-03 498 4 3 0.750 0.006 GO:0043043 BP 1 peptide biosynthetic process 1 Q15031,P46199,Q96RP9 127 2.99e-03 1 4 1 0.250 1.000 GO:0070124 BP 1 mitochondrial translational initiation 1 P46199 127 3.56e-03 549 4 3 0.750 0.005 GO:0043604 BP 1 amide biosynthetic process 1 Q15031,P46199,Q96RP9 127 3.88e-03 758 4 3 0.750 0.004 TF:M04318_1 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 1 1 Q15031,Q4J6C6,Q96RP9 127 4.46e-03 592 4 3 0.750 0.005 GO:0006518 BP 1 peptide metabolic process 1 Q15031,P46199,Q96RP9 127 5.03e-03 115 4 2 0.500 0.017 GO:0032543 BP 1 mitochondrial translation 1 P46199,Q96RP9 127 5.97e-03 2 4 1 0.250 0.500 GO:0004823 MF 1 leucine-tRNA ligase activity 1 Q15031 127 5.97e-03 2 4 1 0.250 0.500 GO:0006429 BP 1 leucyl-tRNA aminoacylation 1 Q15031 127 7.51e-03 706 4 3 0.750 0.004 GO:0043603 BP 1 cellular amide metabolic process 1 Q15031,P46199,Q96RP9 127 7.67e-03 210 4 2 0.500 0.010 TF:M01117_1 tf 1 Factor: OTX; motif: GATTANNT; match class: 1 1 Q4J6C6,Q96RP9 127 8.50e-03 433 4 2 0.500 0.005 MI:hsa-miR-621 mi 1 MI:hsa-miR-621 1 Q15031,Q4J6C6 127 9.38e-03 5 4 1 0.250 0.200 OMIM:233400 omi 1 Perrault Syndrome 1 Q15031 127 9.46e-03 158 4 2 0.500 0.013 GO:0003924 MF 1 GTPase activity 1 P46199,Q96RP9 127 9.68e-03 463 4 2 0.500 0.004 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 P46199,Q4J6C6 127 1.38e-02 556 4 2 0.500 0.004 MI:hsa-miR-34a mi 1 MI:hsa-miR-34a 1 Q15031,Q4J6C6 127 1.43e-02 1182 4 3 0.750 0.003 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 Q15031,P46199,Q4J6C6 127 1.50e-02 8 4 1 0.250 0.125 OMIM:233300 omi 1 Ovarian Dysgenesis 1 Q15031 127 1.62e-02 3064 4 4 1.000 0.001 TF:M04419_0 tf 1 Factor: OTX1; motif: NTAATCCN; match class: 0 1 Q15031,P46199,Q4J6C6,Q96RP9 127 1.89e-02 965 4 3 0.750 0.003 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q15031,P46199,Q96RP9 127 2.09e-02 7 4 1 0.250 0.143 GO:0032790 BP 1 ribosome disassembly 1 P46199 127 2.28e-02 1029 4 3 0.750 0.003 GO:0005739 CC 1 mitochondrion 1 Q15031,P46199,Q96RP9 127 2.31e-02 314 4 2 0.500 0.006 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 P46199,Q96RP9 127 2.36e-02 371 4 2 0.500 0.005 TF:M06192_0 tf 1 Factor: ZNF135; motif: NTGTKGTSCAKA; match class: 0 1 Q15031,Q4J6C6 127 2.51e-02 21 4 1 0.250 0.048 REAC:379726 rea 1 Mitochondrial tRNA aminoacylation 1 Q15031 127 2.76e-02 4399 4 4 1.000 0.001 HPA:021020_02 hpa 1 liver; hepatocytes[Uncertain,Medium] 1 Q15031,P46199,Q4J6C6,Q96RP9 127 2.98e-02 10 4 1 0.250 0.100 GO:0032988 BP 1 ribonucleoprotein complex disassembly 1 P46199 127 3.00e-02 44 4 2 0.500 0.045 HP:0000815 hp 1 Hypergonadotropic hypogonadism 1 Q15031,Q4J6C6 127 3.03e-02 20 4 1 0.250 0.050 TF:M06488_0 tf 1 Factor: ZNF595; motif: NGGGAGGGMWTC; match class: 0 1 P46199 127 3.41e-02 448 4 2 0.500 0.004 TF:M04313_0 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 0 1 Q4J6C6,Q96RP9 127 3.58e-02 12 4 1 0.250 0.083 GO:0043024 MF 1 ribosomal small subunit binding 1 P46199 127 3.58e-02 12 4 1 0.250 0.083 GO:0003746 MF 1 translation elongation factor activity 1 Q96RP9 127 3.70e-02 467 4 2 0.500 0.004 TF:M05868_0 tf 1 Factor: ZNF491; motif: NGKGGKCAGT; match class: 0 1 Q15031,P46199 127 3.78e-02 25 4 1 0.250 0.040 TF:M06496_0 tf 1 Factor: ZNF808; motif: KGGTAAAACCGM; match class: 0 1 Q15031 127 3.89e-02 479 4 2 0.500 0.004 TF:M01714_1 tf 1 Factor: KLF15; motif: GAGNNGGGGNGTDG; match class: 1 1 Q15031,Q4J6C6 127 4.08e-02 27 4 1 0.250 0.037 TF:M00011_1 tf 1 Factor: Evi-1; motif: ACAAGATAA; match class: 1 1 Q4J6C6 127 4.16e-02 3879 4 4 1.000 0.001 TF:M03873_0 tf 1 Factor: HOXA10; motif: ANTTTATG; match class: 0 1 Q15031,P46199,Q4J6C6,Q96RP9 127 4.19e-02 1708 4 3 0.750 0.002 TF:M07264_0 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 0 1 Q15031,P46199,Q4J6C6 127 4.28e-02 503 4 2 0.500 0.004 TF:M03810_1 tf 1 Factor: RXR:PXR; motif: NNNTGAMCTYNNNTGAMCYN; match class: 1 1 P46199,Q4J6C6 127 4.35e-02 3924 4 4 1.000 0.001 TF:M04318_0 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 0 1 Q15031,P46199,Q4J6C6,Q96RP9 127 4.40e-02 344 4 2 0.500 0.006 GO:0005759 CC 1 mitochondrial matrix 1 Q15031,Q96RP9 127 5.00e-02 42 4 1 0.250 0.024 REAC:379724 rea 1 tRNA Aminoacylation 1 Q15031 127 5.00e-02 3185 4 4 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 Q15031,P46199,Q4J6C6,Q96RP9 127 5.00e-02 25 4 1 0.250 0.040 CORUM:5233 cor 1 TNF-alpha/NF-kappa B signaling complex 5 1 P46199 127 5.00e-02 44 4 1 0.250 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 Q15031 127 5.00e-02 4062 4 4 1.000 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 Q15031,P46199,Q4J6C6,Q96RP9 128 4.72e-09 302 7 6 0.857 0.020 GO:0005743 CC 1 mitochondrial inner membrane 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 7.35e-09 325 7 6 0.857 0.018 GO:0019866 CC 1 organelle inner membrane 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 2.52e-08 399 7 6 0.857 0.015 GO:0031966 CC 1 mitochondrial membrane 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 4.18e-08 434 7 6 0.857 0.014 GO:0005740 CC 1 mitochondrial envelope 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 2.35e-07 579 7 6 0.857 0.010 GO:0022857 MF 1 transmembrane transporter activity 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 5.38e-07 665 7 6 0.857 0.009 GO:0031967 CC 1 organelle envelope 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 5.53e-07 668 7 6 0.857 0.009 GO:0031975 CC 1 envelope 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 5.83e-07 674 7 6 0.857 0.009 GO:0044429 CC 1 mitochondrial part 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 1.10e-06 750 7 6 0.857 0.008 GO:0005215 MF 1 transporter activity 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 2.13e-06 3 7 2 0.286 0.667 GO:0015207 MF 1 adenine transmembrane transporter activity 1 P12235,P12236 128 6.95e-06 3 7 2 0.286 0.667 REAC:180897 rea 1 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 1 P12235,P12236 128 7.23e-06 1029 7 6 0.857 0.006 GO:0005739 CC 1 mitochondrion 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 9.30e-06 536 7 5 0.714 0.009 GO:0022891 MF 1 substrate-specific transmembrane transporter activity 1 Q00325,P12235,P25705,P12236,O43772 128 9.52e-06 219 7 4 0.571 0.018 GO:0006839 BP 1 mitochondrial transport 1 P25705,P36542,P12236,O43772 128 1.06e-05 6 7 2 0.286 0.333 GO:0005345 MF 1 purine nucleobase transmembrane transporter activity 1 P12235,P12236 128 1.09e-05 61 7 3 0.429 0.049 GO:1990542 BP 1 mitochondrial transmembrane transport 1 P25705,P36542,O43772 128 1.39e-05 118 7 4 0.571 0.034 KEGG:05012 keg 1 Parkinson's disease 1 P12235,P25705,P36542,P12236 128 1.49e-05 7 7 2 0.286 0.286 GO:0015205 MF 1 nucleobase transmembrane transporter activity 1 P12235,P12236 128 2.55e-05 658 7 5 0.714 0.008 GO:0022892 MF 1 substrate-specific transporter activity 1 Q00325,P12235,P25705,P12236,O43772 128 4.03e-05 94 7 3 0.429 0.032 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 P25705,P36542,P12236 128 4.35e-05 56 7 3 0.429 0.054 REAC:1268020 rea 1 Mitochondrial protein import 1 P12235,P25705,P12236 128 4.74e-05 1414 7 6 0.857 0.004 GO:0031090 CC 1 organelle membrane 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 5.38e-05 166 7 4 0.571 0.024 KEGG:05016 keg 1 Huntington's disease 1 P12235,P25705,P36542,P12236 128 6.64e-05 111 7 3 0.429 0.027 GO:0098798 CC 1 mitochondrial protein complex 1 P25705,P36542,P12236 128 1.08e-04 18 7 2 0.286 0.111 GO:0042776 BP 1 mitochondrial ATP synthesis coupled proton transport 1 P25705,P36542 128 1.21e-04 19 7 2 0.286 0.105 GO:0005753 CC 1 mitochondrial proton-transporting ATP synthase complex 1 P25705,P36542 128 1.21e-04 19 7 2 0.286 0.105 GO:0045259 CC 1 proton-transporting ATP synthase complex 1 P25705,P36542 128 1.42e-04 143 7 3 0.429 0.021 GO:0044455 CC 1 mitochondrial membrane part 1 P25705,P36542,P12236 128 1.79e-04 23 7 2 0.286 0.087 GO:0015986 BP 1 ATP synthesis coupled proton transport 1 P25705,P36542 128 1.79e-04 23 7 2 0.286 0.087 GO:0015985 BP 1 energy coupled proton transport, down electrochemical gradient 1 P25705,P36542 128 2.47e-04 500 7 4 0.571 0.008 GO:0015075 MF 1 ion transmembrane transporter activity 1 Q00325,P25705,P12236,O43772 128 2.76e-04 16 7 2 0.286 0.125 REAC:163210 rea 1 Formation of ATP by chemiosmotic coupling 1 P25705,P36542 128 3.72e-04 33 7 2 0.286 0.061 GO:1902600 BP 1 hydrogen ion transmembrane transport 1 P25705,P36542 128 3.95e-04 34 7 2 0.286 0.059 GO:0016469 CC 1 proton-transporting two-sector ATPase complex 1 P25705,P36542 128 4.18e-04 35 7 2 0.286 0.057 GO:0006754 BP 1 ATP biosynthetic process 1 P25705,P36542 128 4.68e-04 37 7 2 0.286 0.054 GO:0009206 BP 1 purine ribonucleoside triphosphate biosynthetic process 1 P25705,P36542 128 4.68e-04 37 7 2 0.286 0.054 GO:0009145 BP 1 purine nucleoside triphosphate biosynthetic process 1 P25705,P36542 128 4.94e-04 38 7 2 0.286 0.053 GO:0009201 BP 1 ribonucleoside triphosphate biosynthetic process 1 P25705,P36542 128 8.05e-04 257 7 3 0.429 0.012 GO:0006091 BP 1 generation of precursor metabolites and energy 1 Q00325,P12235,P36542 128 8.58e-04 50 7 2 0.286 0.040 GO:0009142 BP 1 nucleoside triphosphate biosynthetic process 1 P25705,P36542 128 8.93e-04 51 7 2 0.286 0.039 GO:0009168 BP 1 purine ribonucleoside monophosphate biosynthetic process 1 P25705,P36542 128 8.93e-04 51 7 2 0.286 0.039 GO:0009127 BP 1 purine nucleoside monophosphate biosynthetic process 1 P25705,P36542 128 9.64e-04 53 7 2 0.286 0.038 GO:0009156 BP 1 ribonucleoside monophosphate biosynthetic process 1 P25705,P36542 128 9.64e-04 53 7 2 0.286 0.038 GO:0015992 BP 1 proton transport 1 P25705,P36542 128 1.04e-03 55 7 2 0.286 0.036 GO:0009124 BP 1 nucleoside monophosphate biosynthetic process 1 P25705,P36542 128 1.04e-03 55 7 2 0.286 0.036 GO:0006818 BP 1 hydrogen transport 1 P25705,P36542 128 1.15e-03 58 7 2 0.286 0.034 GO:0042451 BP 1 purine nucleoside biosynthetic process 1 P25705,P36542 128 1.15e-03 58 7 2 0.286 0.034 GO:0046129 BP 1 purine ribonucleoside biosynthetic process 1 P25705,P36542 128 1.36e-03 35 7 2 0.286 0.057 REAC:176033 rea 1 Interactions of Vpr with host cellular proteins 1 P12235,P12236 128 1.37e-03 1 7 1 0.143 1.000 GO:0015320 MF 1 phosphate ion carrier activity 1 Q00325 128 1.37e-03 1 7 1 0.143 1.000 GO:0005471 MF 1 ATP:ADP antiporter activity 1 P12236 128 1.37e-03 1 7 1 0.143 1.000 GO:0015227 MF 1 acyl carnitine transmembrane transporter activity 1 O43772 128 1.38e-03 1498 7 5 0.714 0.003 GO:0044765 BP 1 single-organism transport 1 P12235,P25705,P36542,P12236,O43772 128 1.45e-03 65 7 2 0.286 0.031 GO:0042455 BP 1 ribonucleoside biosynthetic process 1 P25705,P36542 128 1.73e-03 71 7 2 0.286 0.028 GO:0050796 BP 1 regulation of insulin secretion 1 P12235,P12236 128 1.83e-03 2644 7 6 0.857 0.002 GO:0006810 BP 1 transport 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 2.19e-03 80 7 2 0.286 0.025 GO:0090276 BP 1 regulation of peptide hormone secretion 1 P12235,P12236 128 2.20e-03 1652 7 5 0.714 0.003 GO:1902578 BP 1 single-organism localization 1 P12235,P25705,P36542,P12236,O43772 128 2.25e-03 81 7 2 0.286 0.025 GO:0002791 BP 1 regulation of peptide secretion 1 P12235,P12236 128 2.28e-03 2748 7 6 0.857 0.002 GO:0051234 BP 1 establishment of localization 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 2.36e-03 83 7 2 0.286 0.024 GO:0090087 BP 1 regulation of peptide transport 1 P12235,P12236 128 2.36e-03 83 7 2 0.286 0.024 GO:0009163 BP 1 nucleoside biosynthetic process 1 P25705,P36542 128 2.42e-03 84 7 2 0.286 0.024 GO:0030073 BP 1 insulin secretion 1 P12235,P12236 128 2.47e-03 85 7 2 0.286 0.024 GO:1901659 BP 1 glycosyl compound biosynthetic process 1 P25705,P36542 128 2.73e-03 2 7 1 0.143 0.500 GO:0075528 BP 1 modulation by virus of host immune response 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0044416 BP 1 induction by symbiont of host defense response 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052255 BP 1 modulation by organism of defense response of other organism involved in symbiotic interaction 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0046730 BP 1 induction of host immune response by virus 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0015651 MF 1 quaternary ammonium group transmembrane transporter activity 1 O43772 128 2.73e-03 2 7 1 0.143 0.500 GO:0052509 BP 1 positive regulation by symbiont of host defense response 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052552 BP 1 modulation by organism of immune response of other organism involved in symbiotic interaction 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052251 BP 1 induction by organism of defense response of other organism involved in symbiotic interaction 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0046732 BP 1 active induction of host immune response by virus 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052031 BP 1 modulation by symbiont of host defense response 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052553 BP 1 modulation by symbiont of host immune response 1 P12236 128 2.73e-03 2 7 1 0.143 0.500 GO:0052510 BP 1 positive regulation by organism of defense response of other organism involved in symbiotic interaction 1 P12236 128 2.88e-03 1718 7 6 0.857 0.003 REAC:1430728 rea 1 Metabolism 1 P12235,P25705,Q6P5R6,P36542,P12236,O43772 128 3.15e-03 96 7 2 0.286 0.021 GO:0030072 BP 1 peptide hormone secretion 1 P12235,P12236 128 3.22e-03 97 7 2 0.286 0.021 GO:0002790 BP 1 peptide secretion 1 P12235,P12236 128 3.22e-03 97 7 2 0.286 0.021 GO:0046883 BP 1 regulation of hormone secretion 1 P12235,P12236 128 3.29e-03 416 7 3 0.429 0.007 GO:0034220 BP 1 ion transmembrane transport 1 P25705,P36542,O43772 128 3.83e-03 106 7 2 0.286 0.019 GO:0015833 BP 1 peptide transport 1 P12235,P12236 128 3.97e-03 444 7 3 0.429 0.007 GO:0098796 CC 1 membrane protein complex 1 P25705,P36542,P12236 128 4.09e-03 3 7 1 0.143 0.333 GO:0015217 MF 1 ADP transmembrane transporter activity 1 P12236 128 4.09e-03 3 7 1 0.143 0.333 GO:0052572 BP 1 response to host immune response 1 P12236 128 4.09e-03 3 7 1 0.143 0.333 GO:0052564 BP 1 response to immune response of other organism involved in symbiotic interaction 1 P12236 128 4.20e-03 111 7 2 0.286 0.018 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 P25705,P36542 128 4.35e-03 113 7 2 0.286 0.018 GO:0046879 BP 1 hormone secretion 1 P12235,P12236 128 4.43e-03 114 7 2 0.286 0.018 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 P25705,P36542 128 4.50e-03 115 7 2 0.286 0.017 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 P25705,P36542 128 4.58e-03 116 7 2 0.286 0.017 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 P25705,P36542 128 4.60e-03 1 7 1 0.143 1.000 OMIM:615228 omi 1 MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 4;MC5DN4;;MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, ATP5A1 TYPE 1 P25705 128 4.60e-03 1 7 1 0.143 1.000 OMIM:609283 omi 1 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT 2; PEOA2;;PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, AUTOSOMAL DOMINANT 2 1 P12235 128 4.60e-03 1 7 1 0.143 1.000 OMIM:610773 omi 1 MITOCHONDRIAL PHOSPHATE CARRIER DEFICIENCY;;MPCD 1 Q00325 128 4.60e-03 1 7 1 0.143 1.000 OMIM:616045 omi 1 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 22; COXPD22 1 P25705 128 4.60e-03 1 7 1 0.143 1.000 OMIM:212138 omi 1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY; CACTD;;CACT DEFICIENCY 1 O43772 128 4.60e-03 1 7 1 0.143 1.000 OMIM:615418 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 12 (CARDIOMYOPATHIC TYPE); MTDPS12 1 P12235 128 4.66e-03 117 7 2 0.286 0.017 GO:0042886 BP 1 amide transport 1 P12235,P12236 128 4.66e-03 117 7 2 0.286 0.017 GO:0009914 BP 1 hormone transport 1 P12235,P12236 128 4.68e-03 65 7 2 0.286 0.031 REAC:422356 rea 1 Regulation of insulin secretion 1 P12235,P12236 128 5.46e-03 4 7 1 0.143 0.250 GO:0000275 CC 1 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) 1 P36542 128 5.46e-03 4 7 1 0.143 0.250 GO:0052173 BP 1 response to defenses of other organism involved in symbiotic interaction 1 P12236 128 5.46e-03 4 7 1 0.143 0.250 GO:0052200 BP 1 response to host defenses 1 P12236 128 5.46e-03 4 7 1 0.143 0.250 GO:0075136 BP 1 response to host 1 P12236 128 5.46e-03 4 7 1 0.143 0.250 GO:0045261 CC 1 proton-transporting ATP synthase complex, catalytic core F(1) 1 P36542 128 5.46e-03 4 7 1 0.143 0.250 GO:0005347 MF 1 ATP transmembrane transporter activity 1 P12236 128 5.56e-03 128 7 2 0.286 0.016 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 P25705,P36542 128 5.58e-03 2 7 1 0.143 0.500 REAC:168277 rea 1 Influenza Virus Induced Apoptosis 1 P12236 128 6.09e-03 134 7 2 0.286 0.015 GO:0009165 BP 1 nucleotide biosynthetic process 1 P25705,P36542 128 6.57e-03 529 7 3 0.429 0.006 GO:0055085 BP 1 transmembrane transport 1 P25705,P36542,O43772 128 6.82e-03 5 7 1 0.143 0.200 GO:0060546 BP 1 negative regulation of necroptotic process 1 P12235 128 6.82e-03 5 7 1 0.143 0.200 GO:0033178 CC 1 proton-transporting two-sector ATPase complex, catalytic domain 1 P36542 128 6.82e-03 5 7 1 0.143 0.200 GO:0060547 BP 1 negative regulation of necrotic cell death 1 P12235 128 6.82e-03 5 7 1 0.143 0.200 GO:0000295 MF 1 adenine nucleotide transmembrane transporter activity 1 P12236 128 6.82e-03 5 7 1 0.143 0.200 GO:0005346 MF 1 purine ribonucleotide transmembrane transporter activity 1 P12236 128 7.40e-03 148 7 2 0.286 0.014 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 P25705,P36542 128 7.71e-03 3401 7 6 0.857 0.002 GO:0051179 BP 1 localization 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 7.94e-03 1237 7 4 0.571 0.003 GO:0046907 BP 1 intracellular transport 1 P25705,P36542,P12236,O43772 128 8.18e-03 6 7 1 0.143 0.167 GO:0015101 MF 1 organic cation transmembrane transporter activity 1 O43772 128 8.18e-03 6 7 1 0.143 0.167 GO:0046933 MF 1 proton-transporting ATP synthase activity, rotational mechanism 1 P25705 128 8.18e-03 6 7 1 0.143 0.167 GO:0015216 MF 1 purine nucleotide transmembrane transporter activity 1 P12236 128 8.18e-03 6 7 1 0.143 0.167 GO:0015114 MF 1 phosphate ion transmembrane transporter activity 1 Q00325 128 8.30e-03 574 7 3 0.429 0.005 GO:1902582 BP 1 single-organism intracellular transport 1 P25705,P36542,O43772 128 9.49e-03 168 7 2 0.286 0.012 GO:0008509 MF 1 anion transmembrane transporter activity 1 Q00325,P12236 128 9.50e-03 346 7 3 0.429 0.009 REAC:5663205 rea 1 Infectious disease 1 P12235,Q6P5R6,P12236 128 9.54e-03 7 7 1 0.143 0.143 GO:0015211 MF 1 purine nucleoside transmembrane transporter activity 1 P12236 128 9.70e-03 94 7 2 0.286 0.021 REAC:163685 rea 1 Integration of energy metabolism 1 P12235,P12236 128 9.72e-03 170 7 2 0.286 0.012 GO:0050708 BP 1 regulation of protein secretion 1 P12235,P12236 128 1.06e-02 178 7 2 0.286 0.011 GO:0046034 BP 1 ATP metabolic process 1 P25705,P36542 128 1.09e-02 8 7 1 0.143 0.125 GO:0042288 MF 1 MHC class I protein binding 1 P25705 128 1.13e-02 184 7 2 0.286 0.011 GO:0023061 BP 1 signal release 1 P12235,P12236 128 1.17e-02 187 7 2 0.286 0.011 GO:0022804 MF 1 active transmembrane transporter activity 1 P25705,P12236 128 1.20e-02 189 7 2 0.286 0.011 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P25705,P36542 128 1.21e-02 190 7 2 0.286 0.011 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P25705,P36542 128 1.23e-02 9 7 1 0.143 0.111 GO:0006853 BP 1 carnitine shuttle 1 O43772 128 1.23e-02 9 7 1 0.143 0.111 GO:0005744 CC 1 mitochondrial inner membrane presequence translocase complex 1 P12236 128 1.23e-02 9 7 1 0.143 0.111 GO:0015215 MF 1 nucleotide transmembrane transporter activity 1 P12236 128 1.23e-02 9 7 1 0.143 0.111 GO:0060544 BP 1 regulation of necroptotic process 1 P12235 128 1.24e-02 193 7 2 0.286 0.010 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P25705,P36542 128 1.26e-02 194 7 2 0.286 0.010 GO:0010817 BP 1 regulation of hormone levels 1 P12235,P12236 128 1.29e-02 2412 7 5 0.714 0.002 GO:0044425 CC 1 membrane part 1 Q00325,P12235,P25705,P36542,P12236 128 1.32e-02 110 7 2 0.286 0.018 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P25705,P36542 128 1.34e-02 109 7 2 0.286 0.018 KEGG:00190 keg 1 Oxidative phosphorylation 1 P25705,P36542 128 1.35e-02 201 7 2 0.286 0.010 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P25705,P36542 128 1.35e-02 201 7 2 0.286 0.010 GO:0015672 BP 1 monovalent inorganic cation transport 1 P25705,P36542 128 1.35e-02 201 7 2 0.286 0.010 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P25705,P36542 128 1.36e-02 10 7 1 0.143 0.100 GO:0015605 MF 1 organophosphate ester transmembrane transporter activity 1 P12236 128 1.37e-02 203 7 2 0.286 0.010 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P25705,P36542 128 1.41e-02 206 7 2 0.286 0.010 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P25705,P36542 128 1.45e-02 209 7 2 0.286 0.010 GO:0009306 BP 1 protein secretion 1 P12235,P12236 128 1.47e-02 210 7 2 0.286 0.010 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P25705,P36542 128 1.48e-02 5629 7 7 1.000 0.001 GO:0044444 CC 1 cytoplasmic part 1 Q00325,P12235,P25705,Q6P5R6,P36542,P12236,O43772 128 1.50e-02 11 7 1 0.143 0.091 GO:0005337 MF 1 nucleoside transmembrane transporter activity 1 P12236 128 1.59e-02 1493 7 4 0.571 0.003 GO:0051649 BP 1 establishment of localization in cell 1 P25705,P36542,P12236,O43772 128 1.63e-02 12 7 1 0.143 0.083 GO:0042287 MF 1 MHC protein binding 1 P25705 128 1.63e-02 12 7 1 0.143 0.083 GO:0015301 MF 1 anion:anion antiporter activity 1 P12236 128 1.66e-02 733 7 3 0.429 0.004 GO:0006811 BP 1 ion transport 1 P25705,P36542,O43772 128 1.70e-02 125 7 2 0.286 0.016 REAC:162909 rea 1 Host Interactions of HIV factors 1 P12235,P12236 128 1.77e-02 13 7 1 0.143 0.077 GO:1902001 BP 1 fatty acid transmembrane transport 1 O43772 128 1.77e-02 13 7 1 0.143 0.077 GO:1901677 MF 1 phosphate transmembrane transporter activity 1 P12236 128 1.80e-02 5787 7 7 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q00325,P12235,P25705,Q6P5R6,P36542,P12236,O43772 128 1.83e-02 4 7 1 0.143 0.250 OMIM:604273 omi 1 Mitochondrial Complex V Deficiency 1 P25705 128 1.90e-02 240 7 2 0.286 0.008 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P25705,P36542 128 1.90e-02 240 7 2 0.286 0.008 GO:0098662 BP 1 inorganic cation transmembrane transport 1 P25705,P36542 128 1.91e-02 771 7 3 0.429 0.004 GO:1902580 BP 1 single-organism cellular localization 1 P25705,P36542,O43772 128 1.95e-02 243 7 2 0.286 0.008 GO:0042278 BP 1 purine nucleoside metabolic process 1 P25705,P36542 128 1.99e-02 134 7 2 0.286 0.015 KEGG:04020 keg 1 Calcium signaling pathway 1 P12235,P12236 128 2.00e-02 5877 7 7 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q00325,P12235,P25705,Q6P5R6,P36542,P12236,O43772 128 2.02e-02 135 7 2 0.286 0.015 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 P12235,P12236 128 2.04e-02 15 7 1 0.143 0.067 GO:0044769 MF 1 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1 P25705 128 2.07e-02 251 7 2 0.286 0.008 GO:0009119 BP 1 ribonucleoside metabolic process 1 P25705,P36542 128 2.12e-02 254 7 2 0.286 0.008 GO:0098655 BP 1 cation transmembrane transport 1 P25705,P36542 128 2.17e-02 257 7 2 0.286 0.008 GO:0031012 CC 1 extracellular matrix 1 P25705,P12236 128 2.29e-02 144 7 2 0.286 0.014 KEGG:05010 keg 1 Alzheimer's disease 1 P25705,P36542 128 2.31e-02 17 7 1 0.143 0.059 GO:0010939 BP 1 regulation of necrotic cell death 1 P12235 128 2.37e-02 269 7 2 0.286 0.007 GO:0098660 BP 1 inorganic ion transmembrane transport 1 P25705,P36542 128 2.39e-02 270 7 2 0.286 0.007 GO:1903530 BP 1 regulation of secretion by cell 1 P12235,P12236 128 2.45e-02 151 7 2 0.286 0.013 REAC:168254 rea 1 Influenza Infection 1 Q6P5R6,P12236 128 2.51e-02 153 7 2 0.286 0.013 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P25705,P36542 128 2.58e-02 281 7 2 0.286 0.007 GO:0009116 BP 1 nucleoside metabolic process 1 P25705,P36542 128 2.58e-02 19 7 1 0.143 0.053 GO:0019054 BP 1 modulation by virus of host process 1 P12236 128 2.58e-02 19 7 1 0.143 0.053 GO:0001937 BP 1 negative regulation of endothelial cell proliferation 1 P25705 128 2.65e-02 285 7 2 0.286 0.007 GO:0051046 BP 1 regulation of secretion 1 P12235,P12236 128 2.72e-02 20 7 1 0.143 0.050 GO:0000002 BP 1 mitochondrial genome maintenance 1 P12235 128 2.74e-02 6 7 1 0.143 0.167 OMIM:157640 omi 1 Autosomal Dominant Progressive External Ophthalmoplegia with DNA Deletions 1 P12235 128 2.75e-02 1108 7 3 0.429 0.003 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 P25705,P36542,O43772 128 2.78e-02 10 7 1 0.143 0.100 REAC:200425 rea 1 Import of palmitoyl-CoA into the mitochondrial matrix 1 O43772 128 2.90e-02 299 7 2 0.286 0.007 GO:1901657 BP 1 glycosyl compound metabolic process 1 P25705,P36542 128 2.98e-02 303 7 2 0.286 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P25705,P36542 128 2.99e-02 22 7 1 0.143 0.045 GO:0044068 BP 1 modulation by symbiont of host cellular process 1 P12236 128 2.99e-02 22 7 1 0.143 0.045 GO:0032365 BP 1 intracellular lipid transport 1 O43772 128 2.99e-02 22 7 1 0.143 0.045 GO:0015932 MF 1 nucleobase-containing compound transmembrane transporter activity 1 P12236 128 3.05e-02 307 7 2 0.286 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 P25705,P36542 128 3.12e-02 23 7 1 0.143 0.043 GO:1901505 MF 1 carbohydrate derivative transporter activity 1 P12236 128 3.12e-02 23 7 1 0.143 0.043 GO:0070266 BP 1 necroptotic process 1 P12235 128 3.28e-02 319 7 2 0.286 0.006 GO:0019693 BP 1 ribose phosphate metabolic process 1 P25705,P36542 128 3.36e-02 1836 7 4 0.571 0.002 GO:0051641 BP 1 cellular localization 1 P25705,P36542,P12236,O43772 128 3.38e-02 324 7 2 0.286 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 P25705,P36542 128 3.39e-02 25 7 1 0.143 0.040 GO:0097300 BP 1 programmed necrotic cell death 1 P12235 128 3.56e-02 965 7 3 0.429 0.003 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 P25705,Q6P5R6,P36542 128 3.59e-02 334 7 2 0.286 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 P25705,P36542 128 3.79e-02 344 7 2 0.286 0.006 GO:0005759 CC 1 mitochondrial matrix 1 P25705,P36542 128 3.80e-02 28 7 1 0.143 0.036 GO:0099516 MF 1 ion antiporter activity 1 P12236 128 3.80e-02 28 7 1 0.143 0.036 GO:0015909 BP 1 long-chain fatty acid transport 1 O43772 128 3.92e-02 350 7 2 0.286 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 P25705,P36542 128 4.01e-02 354 7 2 0.286 0.006 GO:0016887 MF 1 ATPase activity 1 P25705,P36542 128 4.06e-02 30 7 1 0.143 0.033 GO:0019048 BP 1 modulation by virus of host morphology or physiology 1 P12236 128 4.16e-02 4600 7 6 0.857 0.001 GO:0016020 CC 1 membrane 1 Q00325,P12235,P25705,P36542,P12236,O43772 128 4.22e-02 364 7 2 0.286 0.005 GO:0008324 MF 1 cation transmembrane transporter activity 1 P25705,O43772 128 4.33e-02 32 7 1 0.143 0.031 GO:1905039 BP 1 carboxylic acid transmembrane transport 1 O43772 128 4.33e-02 32 7 1 0.143 0.031 GO:1903825 BP 1 organic acid transmembrane transport 1 O43772 128 4.33e-02 32 7 1 0.143 0.031 GO:0008180 CC 1 COP9 signalosome 1 P25705 128 4.45e-02 374 7 2 0.286 0.005 GO:0071705 BP 1 nitrogen compound transport 1 P12235,P12236 128 4.55e-02 1169 7 4 0.571 0.003 REAC:392499 rea 1 Metabolism of proteins 1 P12235,P25705,Q6P5R6,P12236 128 4.60e-02 34 7 1 0.143 0.029 GO:0070265 BP 1 necrotic cell death 1 P12235 128 4.77e-02 388 7 2 0.286 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 P25705,P36542 128 4.87e-02 36 7 1 0.143 0.028 GO:0044003 BP 1 modification by symbiont of host morphology or physiology 1 P12236 128 5.00e-02 14 7 2 0.286 0.143 HP:0003535 hp 1 3-Methylglutaconic aciduria 1 P12235,P25705 128 5.00e-02 340 7 3 0.429 0.009 TF:M01759_1 tf 1 Factor: AML2; motif: AACCRCAA; match class: 1 1 P25705,P36542,O43772 128 5.00e-02 523 7 4 0.571 0.008 MI:hsa-miR-582-3p mi 1 MI:hsa-miR-582-3p 1 P12235,P25705,P36542,O43772 128 5.00e-02 218 7 2 0.286 0.009 KEGG:05166 keg 1 HTLV-I infection 1 P12235,P12236 128 5.00e-02 398 7 2 0.286 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P25705,P36542 128 5.00e-02 15 7 2 0.286 0.133 CORUM:563 cor 1 F1F0-ATP synthase (EC 3.6.3.14), mitochondrial 1 P25705,P36542 128 5.00e-02 340 7 3 0.429 0.009 TF:M01856_1 tf 1 Factor: AML3; motif: AACCACAN; match class: 1 1 P25705,P36542,O43772 128 5.00e-02 219 7 2 0.286 0.009 REAC:162906 rea 1 HIV Infection 1 P12235,P12236 128 5.00e-02 11 7 1 0.143 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 P12235 129 1.39e-03 2 2 1 0.500 0.500 GO:0004531 MF 1 deoxyribonuclease II activity 1 Q8WZ79 129 4.87e-03 7 2 1 0.500 0.143 GO:0010714 BP 1 positive regulation of collagen metabolic process 1 Q9UBS9 129 4.87e-03 7 2 1 0.500 0.143 GO:0032967 BP 1 positive regulation of collagen biosynthetic process 1 Q9UBS9 129 4.87e-03 7 2 1 0.500 0.143 GO:0044253 BP 1 positive regulation of multicellular organismal metabolic process 1 Q9UBS9 129 5.57e-03 8 2 1 0.500 0.125 GO:0032965 BP 1 regulation of collagen biosynthetic process 1 Q9UBS9 129 6.27e-03 9 2 1 0.500 0.111 GO:0016889 MF 1 endodeoxyribonuclease activity, producing 3'-phosphomonoesters 1 Q8WZ79 129 8.36e-03 12 2 1 0.500 0.083 GO:0016894 MF 1 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1 Q8WZ79 129 8.36e-03 12 2 1 0.500 0.083 GO:0010712 BP 1 regulation of collagen metabolic process 1 Q9UBS9 129 8.36e-03 12 2 1 0.500 0.083 GO:0044246 BP 1 regulation of multicellular organismal metabolic process 1 Q9UBS9 129 8.36e-03 12 2 1 0.500 0.083 GO:0032964 BP 1 collagen biosynthetic process 1 Q9UBS9 129 9.05e-03 13 2 1 0.500 0.077 GO:0046850 BP 1 regulation of bone remodeling 1 Q9UBS9 129 1.11e-02 16 2 1 0.500 0.062 GO:0006309 BP 1 apoptotic DNA fragmentation 1 Q8WZ79 129 1.32e-02 19 2 1 0.500 0.053 GO:0000737 BP 1 DNA catabolic process, endonucleolytic 1 Q8WZ79 129 1.39e-02 20 2 1 0.500 0.050 GO:0046849 BP 1 bone remodeling 1 Q9UBS9 129 1.46e-02 21 2 1 0.500 0.048 GO:0034103 BP 1 regulation of tissue remodeling 1 Q9UBS9 129 1.46e-02 21 2 1 0.500 0.048 GO:0030262 BP 1 apoptotic nuclear changes 1 Q8WZ79 129 1.53e-02 22 2 1 0.500 0.045 GO:0045669 BP 1 positive regulation of osteoblast differentiation 1 Q9UBS9 129 1.60e-02 23 2 1 0.500 0.043 GO:0006308 BP 1 DNA catabolic process 1 Q8WZ79 129 1.95e-02 28 2 1 0.500 0.036 GO:0005791 CC 1 rough endoplasmic reticulum 1 Q9UBS9 129 2.30e-02 33 2 1 0.500 0.030 GO:0045778 BP 1 positive regulation of ossification 1 Q9UBS9 129 2.64e-02 38 2 1 0.500 0.026 GO:0048771 BP 1 tissue remodeling 1 Q9UBS9 129 2.71e-02 39 2 1 0.500 0.026 GO:0006921 BP 1 cellular component disassembly involved in execution phase of apoptosis 1 Q8WZ79 129 2.78e-02 40 2 1 0.500 0.025 GO:0004520 MF 1 endodeoxyribonuclease activity 1 Q8WZ79 129 3.13e-02 45 2 1 0.500 0.022 GO:0045667 BP 1 regulation of osteoblast differentiation 1 Q9UBS9 129 3.89e-02 56 2 1 0.500 0.018 GO:0004536 MF 1 deoxyribonuclease activity 1 Q8WZ79 129 4.24e-02 61 2 1 0.500 0.016 GO:0097194 BP 1 execution phase of apoptosis 1 Q8WZ79 129 4.58e-02 66 2 1 0.500 0.015 GO:0032963 BP 1 collagen metabolic process 1 Q9UBS9 129 4.79e-02 69 2 1 0.500 0.014 GO:0030278 BP 1 regulation of ossification 1 Q9UBS9 129 4.79e-02 69 2 1 0.500 0.014 GO:0044259 BP 1 multicellular organismal macromolecule metabolic process 1 Q9UBS9 129 5.00e-02 111 2 1 0.500 0.009 KEGG:04142 keg 1 Lysosome 1 Q8WZ79 129 5.00e-02 72 2 1 0.500 0.014 GO:0044236 BP 1 multicellular organism metabolic process 1 Q9UBS9 129 5.00e-02 1 2 1 0.500 1.000 TF:M03912_1 tf 1 Factor: KLF13; motif: NTGMCACGCCCCTTTTTG; match class: 1 1 Q9UBS9 130 3.62e-03 394 3 2 0.667 0.005 MI:hsa-miR-129-5p mi 1 MI:hsa-miR-129-5p 1 P49006,Q99729 130 4.18e-03 424 3 2 0.667 0.005 MI:hsa-miR-555 mi 1 MI:hsa-miR-555 1 P49006,Q13151 130 5.39e-03 482 3 2 0.667 0.004 MI:mmu-miR-464 mi 1 MI:mmu-miR-464 1 P49006,Q99729 130 5.57e-03 4 3 1 0.333 0.250 TF:M03903_0 tf 1 Factor: GLIS1; motif: MGACCCCCCACGAWGN; match class: 0 1 Q99729 130 1.30e-02 1658 3 3 1.000 0.002 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 P49006,Q13151,Q99729 130 1.92e-02 1886 3 3 1.000 0.002 TF:M00217_1 tf 1 Factor: USF; motif: NCACGTGN; match class: 1 1 P49006,Q13151,Q99729 130 2.90e-02 49 3 1 0.333 0.020 KEGG:05140 keg 1 Leishmaniasis 1 P49006 130 3.11e-02 2215 3 3 1.000 0.001 TF:M07341_1 tf 1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 1 P49006,Q13151,Q99729 130 3.16e-02 12 3 1 0.333 0.083 GO:0070935 BP 1 3'-UTR-mediated mRNA stabilization 1 Q13151 130 3.48e-02 25 3 1 0.333 0.040 TF:M05428_0 tf 1 Factor: RP58; motif: NGGGGCAAGSCM; match class: 0 1 Q13151 130 3.75e-02 27 3 1 0.333 0.037 TF:M05797_0 tf 1 Factor: ZNF613; motif: NGGTTAAAAATA; match class: 0 1 Q13151 130 4.40e-02 2487 3 3 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 P49006,Q13151,Q99729 130 4.40e-02 2487 3 3 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 P49006,Q13151,Q99729 130 4.40e-02 2487 3 3 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 P49006,Q13151,Q99729 130 5.00e-02 36 3 1 0.333 0.028 TF:M04161_1 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 1 1 Q13151 130 5.00e-02 19 3 1 0.333 0.053 GO:0017091 MF 1 AU-rich element binding 1 Q13151 130 5.00e-02 329 3 2 0.667 0.006 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 P49006,Q99729 130 5.00e-02 85 3 1 0.333 0.012 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 P49006 130 5.00e-02 36 3 1 0.333 0.028 TF:M04161_0 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 0 1 Q13151 131 2.50e-03 2 2 1 0.500 0.500 GO:0034988 MF 1 Fc-gamma receptor I complex binding 1 P09769 131 2.50e-03 2 2 1 0.500 0.500 GO:0000308 CC 1 cytoplasmic cyclin-dependent protein kinase holoenzyme complex 1 O94921 131 6.26e-03 5 2 1 0.500 0.200 GO:0001784 MF 1 phosphotyrosine binding 1 P09769 131 6.82e-03 11 2 1 0.500 0.091 REAC:2029481 rea 1 FCGR activation 1 P09769 131 7.51e-03 6 2 1 0.500 0.167 GO:0034987 MF 1 immunoglobulin receptor binding 1 P09769 131 8.76e-03 7 2 1 0.500 0.143 GO:0043306 BP 1 positive regulation of mast cell degranulation 1 P09769 131 8.76e-03 7 2 1 0.500 0.143 GO:0033008 BP 1 positive regulation of mast cell activation involved in immune response 1 P09769 131 9.92e-03 16 2 1 0.500 0.062 REAC:432142 rea 1 Platelet sensitization by LDL 1 P09769 131 1.00e-02 8 2 1 0.500 0.125 GO:0033005 BP 1 positive regulation of mast cell activation 1 P09769 131 1.13e-02 9 2 1 0.500 0.111 GO:0002888 BP 1 positive regulation of myeloid leukocyte mediated immunity 1 P09769 131 1.21e-02 472 2 2 1.000 0.004 GO:0004672 MF 1 protein kinase activity 1 P09769,O94921 131 1.38e-02 11 2 1 0.500 0.091 GO:0045309 MF 1 protein phosphorylated amino acid binding 1 P09769 131 1.38e-02 11 2 1 0.500 0.091 GO:0043302 BP 1 positive regulation of leukocyte degranulation 1 P09769 131 1.75e-02 14 2 1 0.500 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 O94921 131 1.75e-02 14 2 1 0.500 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 O94921 131 1.75e-02 14 2 1 0.500 0.071 GO:0030332 MF 1 cyclin binding 1 O94921 131 1.81e-02 578 2 2 1.000 0.003 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P09769,O94921 131 2.00e-02 16 2 1 0.500 0.062 GO:0043552 BP 1 positive regulation of phosphatidylinositol 3-kinase activity 1 P09769 131 2.13e-02 17 2 1 0.500 0.059 GO:0043304 BP 1 regulation of mast cell degranulation 1 P09769 131 2.13e-02 17 2 1 0.500 0.059 GO:0033006 BP 1 regulation of mast cell activation involved in immune response 1 P09769 131 2.15e-02 630 2 2 1.000 0.003 GO:0016301 MF 1 kinase activity 1 P09769,O94921 131 2.25e-02 18 2 1 0.500 0.056 GO:0090218 BP 1 positive regulation of lipid kinase activity 1 P09769 131 2.38e-02 19 2 1 0.500 0.053 GO:0033003 BP 1 regulation of mast cell activation 1 P09769 131 2.50e-02 20 2 1 0.500 0.050 GO:0002886 BP 1 regulation of myeloid leukocyte mediated immunity 1 P09769 131 2.63e-02 21 2 1 0.500 0.048 GO:0002279 BP 1 mast cell activation involved in immune response 1 P09769 131 2.63e-02 21 2 1 0.500 0.048 GO:0043551 BP 1 regulation of phosphatidylinositol 3-kinase activity 1 P09769 131 2.63e-02 21 2 1 0.500 0.048 GO:0043303 BP 1 mast cell degranulation 1 P09769 131 2.75e-02 22 2 1 0.500 0.045 GO:1903307 BP 1 positive regulation of regulated secretory pathway 1 P09769 131 2.75e-02 22 2 1 0.500 0.045 GO:0002448 BP 1 mast cell mediated immunity 1 P09769 131 2.75e-02 22 2 1 0.500 0.045 GO:0043300 BP 1 regulation of leukocyte degranulation 1 P09769 131 2.75e-02 22 2 1 0.500 0.045 GO:1903727 BP 1 positive regulation of phospholipid metabolic process 1 P09769 131 2.88e-02 23 2 1 0.500 0.043 GO:0045576 BP 1 mast cell activation 1 P09769 131 3.00e-02 24 2 1 0.500 0.042 GO:0050830 BP 1 defense response to Gram-positive bacterium 1 P09769 131 3.09e-02 755 2 2 1.000 0.003 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P09769,O94921 131 3.38e-02 27 2 1 0.500 0.037 GO:0043550 BP 1 regulation of lipid kinase activity 1 P09769 131 3.63e-02 29 2 1 0.500 0.034 GO:0014068 BP 1 positive regulation of phosphatidylinositol 3-kinase signaling 1 P09769 131 3.75e-02 30 2 1 0.500 0.033 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 O94921 131 3.75e-02 30 2 1 0.500 0.033 GO:0043299 BP 1 leukocyte degranulation 1 P09769 131 3.87e-02 219 2 1 0.500 0.005 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 P09769 131 3.88e-02 31 2 1 0.500 0.032 GO:0002275 BP 1 myeloid cell activation involved in immune response 1 P09769 131 3.88e-02 31 2 1 0.500 0.032 GO:1903725 BP 1 regulation of phospholipid metabolic process 1 P09769 131 4.00e-02 32 2 1 0.500 0.031 GO:0051219 MF 1 phosphoprotein binding 1 P09769 131 4.13e-02 33 2 1 0.500 0.030 GO:0002444 BP 1 myeloid leukocyte mediated immunity 1 P09769 131 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 P09769 131 4.45e-02 72 2 1 0.500 0.014 REAC:418346 rea 1 Platelet homeostasis 1 P09769 131 4.50e-02 36 2 1 0.500 0.028 GO:0002705 BP 1 positive regulation of leukocyte mediated immunity 1 P09769 131 4.50e-02 36 2 1 0.500 0.028 GO:0004715 MF 1 non-membrane spanning protein tyrosine kinase activity 1 P09769 131 4.63e-02 37 2 1 0.500 0.027 GO:0032418 BP 1 lysosome localization 1 P09769 131 4.63e-02 37 2 1 0.500 0.027 GO:0050764 BP 1 regulation of phagocytosis 1 P09769 131 4.63e-02 37 2 1 0.500 0.027 GO:0038083 BP 1 peptidyl-tyrosine autophosphorylation 1 P09769 131 4.79e-02 115 2 1 0.500 0.009 KEGG:05202 keg 1 Transcriptional misregulation in cancer 1 O94921 131 5.00e-02 40 2 1 0.500 0.025 GO:0050715 BP 1 positive regulation of cytokine secretion 1 P09769 131 5.00e-02 120 2 1 0.500 0.008 KEGG:04062 keg 1 Chemokine signaling pathway 1 P09769 131 5.00e-02 81 2 1 0.500 0.012 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 P09769 131 5.00e-02 40 2 1 0.500 0.025 GO:0032587 CC 1 ruffle membrane 1 P09769 131 5.00e-02 287 2 2 1.000 0.007 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 P09769,O94921 132 1.06e-02 452 2 2 1.000 0.004 TF:M01869_1 tf 1 Factor: C/EBPgamma; motif: NRTKRSRMAAKN; match class: 1 1 Q96HW7,Q8WYP5 132 2.92e-02 751 2 2 1.000 0.003 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 Q96HW7,Q8WYP5 132 3.16e-02 24 2 1 0.500 0.042 TF:M04204_1 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 1 1 Q96HW7 132 4.34e-02 33 2 1 0.500 0.030 TF:M06334_0 tf 1 Factor: ZNF782; motif: NGTTAAAAAASA; match class: 0 1 Q8WYP5 132 4.74e-02 36 2 1 0.500 0.028 TF:M04202_1 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 1 1 Q96HW7 132 5.00e-02 10 2 1 0.500 0.100 GO:0051292 BP 1 nuclear pore complex assembly 1 Q8WYP5 132 5.00e-02 12 2 1 0.500 0.083 CORUM:1154 cor 1 DSS1 complex 1 Q96HW7 132 5.00e-02 38 2 1 0.500 0.026 TF:M04201_1 tf 1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 1 1 Q96HW7 132 5.00e-02 10 2 1 0.500 0.100 GO:0031080 CC 1 nuclear pore outer ring 1 Q8WYP5 132 5.00e-02 12 2 1 0.500 0.083 CORUM:1153 cor 1 Integrator complex 1 Q96HW7 132 5.00e-02 70 2 1 0.500 0.014 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 Q96HW7 133 1.57e-03 10 2 1 0.500 0.100 TF:M07076_1 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 1 1 Q8N7C3 133 3.61e-03 23 2 1 0.500 0.043 TF:M03918_0 tf 1 Factor: SCRT2; motif: RWGCAACAGGTGN; match class: 0 1 Q8N7C3 133 4.55e-03 29 2 1 0.500 0.034 TF:M03917_0 tf 1 Factor: SCRT1; motif: RNGCAACAGGTGGNN; match class: 0 1 Q8N7C3 133 1.00e-02 64 2 1 0.500 0.016 TF:M05826_0 tf 1 Factor: ZNF66; motif: GTSTTCAACTWA; match class: 0 1 Q86T24 133 1.13e-02 72 2 1 0.500 0.014 TF:M05338_0 tf 1 Factor: HOXB3; motif: NCCTTATTAAA; match class: 0 1 Q8N7C3 133 1.13e-02 72 2 1 0.500 0.014 TF:M05340_0 tf 1 Factor: HOXB2; motif: NCCTTATTAAA; match class: 0 1 Q8N7C3 133 1.13e-02 72 2 1 0.500 0.014 TF:M05456_0 tf 1 Factor: gsh-1; motif: TCCTTATTAAA; match class: 0 1 Q8N7C3 133 1.13e-02 72 2 1 0.500 0.014 TF:M01124_1 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1 Q8N7C3 133 1.16e-02 1374 2 2 1.000 0.001 TF:M00478_0 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 0 1 Q86T24,Q8N7C3 133 1.19e-02 76 2 1 0.500 0.013 TF:M00639_0 tf 1 Factor: HNF-6; motif: HWAAATCAATAW; match class: 0 1 Q86T24 133 1.22e-02 78 2 1 0.500 0.013 TF:M03956_0 tf 1 Factor: ONECUT2; motif: NAAAAATCRATANN; match class: 0 1 Q86T24 133 1.40e-02 1504 2 2 1.000 0.001 TF:M05313_0 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 0 1 Q86T24,Q8N7C3 133 1.50e-02 1557 2 2 1.000 0.001 TF:M07044_1 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 1 Q86T24,Q8N7C3 133 1.58e-02 1598 2 2 1.000 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 Q86T24,Q8N7C3 133 1.67e-02 107 2 1 0.500 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 Q86T24 133 1.69e-02 108 2 1 0.500 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q86T24 133 2.13e-02 136 2 1 0.500 0.007 TF:M01002_1 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 1 1 Q86T24 133 2.28e-02 1924 2 2 1.000 0.001 TF:M04340_1 tf 1 Factor: HOXA10; motif: NGYMATAAAAN; match class: 1 1 Q86T24,Q8N7C3 133 2.59e-02 2050 2 2 1.000 0.001 TF:M00216_1 tf 1 Factor: TATA; motif: NCTATAAAAR; match class: 1 1 Q86T24,Q8N7C3 133 2.67e-02 171 2 1 0.500 0.006 TF:M00926_1 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 1 1 Q8N7C3 133 2.67e-02 171 2 1 0.500 0.006 TF:M01267_1 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 1 1 Q8N7C3 133 2.68e-02 172 2 1 0.500 0.006 TF:M03941_0 tf 1 Factor: ZNF784; motif: GTACCTACCT; match class: 0 1 Q86T24 133 2.79e-02 179 2 1 0.500 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 Q8N7C3 133 3.25e-02 2296 2 2 1.000 0.001 TF:M07037_1 tf 1 Factor: C/EBPalpha; motif: NNNNNTTKCNNAAN; match class: 1 1 Q86T24,Q8N7C3 133 3.30e-02 2314 2 2 1.000 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 Q86T24,Q8N7C3 133 3.52e-02 226 2 1 0.500 0.004 TF:M00925_1 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 1 1 Q8N7C3 133 3.55e-02 228 2 1 0.500 0.004 TF:M01306_1 tf 1 Factor: ZABC1; motif: ATTCCNAC; match class: 1 1 Q86T24 133 3.66e-02 235 2 1 0.500 0.004 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 Q8N7C3 133 3.67e-02 236 2 1 0.500 0.004 TF:M04427_1 tf 1 Factor: PHOX2B; motif: TAATYYAATTA; match class: 1 1 Q8N7C3 133 3.75e-02 241 2 1 0.500 0.004 TF:M04308_1 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 1 1 Q8N7C3 133 3.87e-02 249 2 1 0.500 0.004 TF:M00405_1 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 1 1 Q86T24 133 3.89e-02 2511 2 2 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q86T24,Q8N7C3 133 3.94e-02 2527 2 2 1.000 0.001 TF:M02085_0 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 0 1 Q86T24,Q8N7C3 133 4.12e-02 265 2 1 0.500 0.004 TF:M04426_1 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 1 1 Q8N7C3 133 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 Q8N7C3 133 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 Q8N7C3 133 4.31e-02 277 2 1 0.500 0.004 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q8N7C3 133 4.32e-02 2646 2 2 1.000 0.001 TF:M00632_0 tf 1 Factor: GATA-4; motif: AGATADMAGGGA; match class: 0 1 Q86T24,Q8N7C3 133 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q8N7C3 133 4.95e-02 319 2 1 0.500 0.003 TF:M01022_1 tf 1 Factor: LEF-1; motif: NWTCAAAGNN; match class: 1 1 Q86T24 133 5.00e-02 10 2 1 0.500 0.100 CORUM:2183 cor 1 Kaiso-NCOR complex 1 Q86T24 134 6.44e-09 4 4 3 0.750 0.750 OMIM:168000 omi 1 Paragangliomas 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0003334 hp 1 Elevated circulating catecholamine level 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0001686 hp 1 Loss of voice 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0006748 hp 1 Adrenal pheochromocytoma 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0002864 hp 1 Paraganglioma of head and neck 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0100642 hp 1 Neoplasm of the adrenal medulla 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0012099 hp 1 Abnormality of circulating catecholamine level 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0003001 hp 1 Glomus jugular tumor 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0006715 hp 1 Glomus tympanicum paraganglioma 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0002331 hp 1 Recurrent paroxysmal headache 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0030074 hp 1 Chemodectoma 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0002886 hp 1 Vagal paraganglioma 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0000740 hp 1 Episodic paroxysmal anxiety 1 P31040,P21912,Q9NX18 134 1.79e-07 7 4 3 0.750 0.429 HP:0006737 hp 1 Extraadrenal pheochromocytoma 1 P31040,P21912,Q9NX18 134 2.05e-07 2 4 2 0.500 1.000 GO:0000104 MF 1 succinate dehydrogenase activity 1 P31040,P21912 134 2.86e-07 8 4 3 0.750 0.375 HP:0002668 hp 1 Paraganglioma 1 P31040,P21912,Q9NX18 134 4.29e-07 9 4 3 0.750 0.333 HP:0002640 hp 1 Hypertension associated with pheochromocytoma 1 P31040,P21912,Q9NX18 134 4.29e-07 9 4 3 0.750 0.333 HP:0003345 hp 1 Elevated urinary norepinephrine 1 P31040,P21912,Q9NX18 134 4.29e-07 9 4 3 0.750 0.333 HP:0000875 hp 1 Episodic hypertension 1 P31040,P21912,Q9NX18 134 4.29e-07 9 4 3 0.750 0.333 HP:0003574 hp 1 Positive regitine blocking test 1 P31040,P21912,Q9NX18 134 4.29e-07 9 4 3 0.750 0.333 HP:0001095 hp 1 Hypertensive retinopathy 1 P31040,P21912,Q9NX18 134 6.15e-07 3 4 2 0.500 0.667 GO:0045273 CC 1 respiratory chain complex II 1 P31040,P21912 134 6.15e-07 3 4 2 0.500 0.667 GO:0006121 BP 1 mitochondrial electron transport, succinate to ubiquinone 1 P31040,Q9NX18 134 6.15e-07 3 4 2 0.500 0.667 GO:0045283 CC 1 fumarate reductase complex 1 P31040,P21912 134 6.15e-07 3 4 2 0.500 0.667 GO:0045281 CC 1 succinate dehydrogenase complex 1 P31040,P21912 134 6.15e-07 3 4 2 0.500 0.667 GO:0045257 CC 1 succinate dehydrogenase complex (ubiquinone) 1 P31040,P21912 134 6.15e-07 3 4 2 0.500 0.667 GO:0005749 CC 1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 1 P31040,P21912 134 8.42e-07 11 4 3 0.750 0.273 HP:0002666 hp 1 Pheochromocytoma 1 P31040,P21912,Q9NX18 134 1.13e-06 29 4 3 0.750 0.103 KEGG:00020 keg 1 Citrate cycle (TCA cycle) 1 P31040,P21912,P29803 134 1.86e-06 14 4 3 0.750 0.214 HP:0011976 hp 1 Elevated urinary catecholamines 1 P31040,P21912,Q9NX18 134 1.86e-06 14 4 3 0.750 0.214 HP:0011281 hp 1 Abnormality of urine catecholamine concentration 1 P31040,P21912,Q9NX18 134 2.32e-06 15 4 3 0.750 0.200 HP:0100723 hp 1 Gastrointestinal stroma tumor 1 P31040,P21912,Q9NX18 134 2.90e-06 80 4 3 0.750 0.037 GO:0022900 BP 1 electron transport chain 1 P31040,P21912,Q9NX18 134 2.90e-06 80 4 3 0.750 0.037 GO:0022904 BP 1 respiratory electron transport chain 1 P31040,P21912,Q9NX18 134 3.46e-06 17 4 3 0.750 0.176 HP:0001920 hp 1 Renal artery stenosis 1 P31040,P21912,Q9NX18 134 3.46e-06 17 4 3 0.750 0.176 HP:0100634 hp 1 Neuroendocrine neoplasm 1 P31040,P21912,Q9NX18 134 3.46e-06 17 4 3 0.750 0.176 HP:0008776 hp 1 Abnormality of the renal artery 1 P31040,P21912,Q9NX18 134 6.86e-06 2 4 2 0.500 1.000 HP:0004897 hp 1 Stress/infection-induced lactic acidosis 1 P31040,P21912 134 7.83e-06 22 4 3 0.750 0.136 HP:0100631 hp 1 Neoplasm of the adrenal gland 1 P31040,P21912,Q9NX18 134 7.83e-06 22 4 3 0.750 0.136 HP:0001342 hp 1 Cerebral hemorrhage 1 P31040,P21912,Q9NX18 134 1.26e-05 130 4 3 0.750 0.023 GO:0045333 BP 1 cellular respiration 1 P31040,P21912,Q9NX18 134 2.06e-05 3 4 2 0.500 0.667 HP:0008314 hp 1 Decreased activity of mitochondrial complex II 1 P31040,P21912 134 2.06e-05 3 4 2 0.500 0.667 HP:0006980 hp 1 Progressive leukoencephalopathy 1 P31040,P21912 134 2.52e-05 32 4 3 0.750 0.094 HP:0003072 hp 1 Hypercalcemia 1 P31040,P21912,Q9NX18 134 2.77e-05 33 4 3 0.750 0.091 HP:0100007 hp 1 Neoplasm of the peripheral nervous system 1 P31040,P21912,Q9NX18 134 3.41e-05 181 4 3 0.750 0.017 GO:0015980 BP 1 energy derivation by oxidation of organic compounds 1 P31040,P21912,Q9NX18 134 5.64e-05 24 4 2 0.500 0.083 GO:0006099 BP 1 tricarboxylic acid cycle 1 P31040,P21912 134 6.09e-05 107 4 3 0.750 0.028 KEGG:01200 keg 1 Carbon metabolism 1 P31040,P21912,P29803 134 6.69e-05 44 4 3 0.750 0.068 HP:0005584 hp 1 Renal cell carcinoma 1 P31040,P21912,Q9NX18 134 7.17e-05 45 4 3 0.750 0.067 HP:0030065 hp 1 Primitive neuroectodermal tumor 1 P31040,P21912,Q9NX18 134 7.17e-05 45 4 3 0.750 0.067 HP:0004376 hp 1 Neuroblastic tumors 1 P31040,P21912,Q9NX18 134 7.17e-05 45 4 3 0.750 0.067 HP:0003006 hp 1 Neuroblastoma 1 P31040,P21912,Q9NX18 134 7.17e-05 45 4 3 0.750 0.067 HP:0030067 hp 1 Peripheral primitive neuroectodermal neoplasm 1 P31040,P21912,Q9NX18 134 7.72e-05 28 4 2 0.500 0.071 GO:0006101 BP 1 citrate metabolic process 1 P31040,P21912 134 9.77e-05 257 4 3 0.750 0.012 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P31040,P21912,Q9NX18 134 1.01e-04 32 4 2 0.500 0.062 GO:0072350 BP 1 tricarboxylic acid metabolic process 1 P31040,P21912 134 1.05e-04 51 4 3 0.750 0.059 HP:0002170 hp 1 Intracranial hemorrhage 1 P31040,P21912,Q9NX18 134 1.43e-04 1029 4 4 1.000 0.004 GO:0005739 CC 1 mitochondrion 1 P31040,P21912,P29803,Q9NX18 134 1.90e-04 62 4 3 0.750 0.048 HP:0001962 hp 1 Palpitations 1 P31040,P21912,Q9NX18 134 2.00e-04 63 4 3 0.750 0.048 HP:0100742 hp 1 Vascular neoplasm 1 P31040,P21912,Q9NX18 134 2.00e-04 63 4 3 0.750 0.048 HP:0001028 hp 1 Hemangioma 1 P31040,P21912,Q9NX18 134 2.02e-04 45 4 2 0.500 0.044 GO:0016627 MF 1 oxidoreductase activity, acting on the CH-CH group of donors 1 P31040,P21912 134 2.09e-04 64 4 3 0.750 0.047 HP:0030063 hp 1 Neuroepithelial neoplasm 1 P31040,P21912,Q9NX18 134 2.09e-04 64 4 3 0.750 0.047 HP:0030061 hp 1 Neuroectodermal neoplasm 1 P31040,P21912,Q9NX18 134 2.09e-04 64 4 3 0.750 0.047 HP:0030060 hp 1 Nervous tissue neoplasm 1 P31040,P21912,Q9NX18 134 2.30e-04 66 4 3 0.750 0.045 HP:0100836 hp 1 Malignant neoplasm of the central nervous system 1 P31040,P21912,Q9NX18 134 2.30e-04 66 4 3 0.750 0.045 HP:0011732 hp 1 Abnormality of adrenal morphology 1 P31040,P21912,Q9NX18 134 2.30e-04 48 4 2 0.500 0.042 GO:0009060 BP 1 aerobic respiration 1 P31040,P21912 134 2.41e-04 67 4 3 0.750 0.045 HP:0040077 hp 1 Abnormal concentration of calcium in blood 1 P31040,P21912,Q9NX18 134 2.99e-04 72 4 3 0.750 0.042 HP:0100568 hp 1 Neoplasm of the endocrine system 1 P31040,P21912,Q9NX18 134 3.02e-04 375 4 3 0.750 0.008 GO:0055114 BP 1 oxidation-reduction process 1 P31040,P21912,Q9NX18 134 3.76e-04 11 4 2 0.500 0.182 HP:0001067 hp 1 Neurofibromas 1 P31040,P21912 134 3.85e-04 62 4 2 0.500 0.032 GO:0098803 CC 1 respiratory chain complex 1 P31040,P21912 134 4.03e-04 1333 4 4 1.000 0.003 GO:0044281 BP 1 small molecule metabolic process 1 P31040,P21912,P29803,Q9NX18 134 4.10e-04 64 4 2 0.500 0.031 GO:0005746 CC 1 mitochondrial respiratory chain 1 P31040,P21912 134 4.11e-04 80 4 3 0.750 0.037 HP:0000957 hp 1 Cafe-au-lait spot 1 P31040,P21912,Q9NX18 134 4.50e-04 67 4 2 0.500 0.030 GO:0070469 CC 1 respiratory chain 1 P31040,P21912 134 4.76e-04 84 4 3 0.750 0.036 HP:0000519 hp 1 Congenital cataract 1 P31040,P21912,Q9NX18 134 5.05e-04 71 4 2 0.500 0.028 GO:0042775 BP 1 mitochondrial ATP synthesis coupled electron transport 1 P31040,Q9NX18 134 5.19e-04 72 4 2 0.500 0.028 GO:0042773 BP 1 ATP synthesis coupled electron transport 1 P31040,Q9NX18 134 5.19e-04 72 4 2 0.500 0.028 GO:0009055 MF 1 electron carrier activity 1 P31040,P21912 134 5.32e-04 13 4 2 0.500 0.154 HP:0012288 hp 1 Neoplasm of head and neck 1 P31040,P21912 134 5.32e-04 13 4 2 0.500 0.154 HP:0100751 hp 1 Esophageal neoplasm 1 P31040,P21912 134 5.67e-04 89 4 3 0.750 0.034 HP:0004363 hp 1 Abnormality of calcium homeostasis 1 P31040,P21912,Q9NX18 134 6.06e-04 91 4 3 0.750 0.033 HP:0009726 hp 1 Renal neoplasm 1 P31040,P21912,Q9NX18 134 6.06e-04 91 4 3 0.750 0.033 HP:0010927 hp 1 Abnormality of divalent inorganic cation homeostasis 1 P31040,P21912,Q9NX18 134 6.10e-04 78 4 2 0.500 0.026 GO:1990204 CC 1 oxidoreductase complex 1 P31040,P21912 134 6.26e-04 92 4 3 0.750 0.033 HP:0000975 hp 1 Hyperhidrosis 1 P31040,P21912,Q9NX18 134 6.31e-04 480 4 3 0.750 0.006 GO:0016491 MF 1 oxidoreductase activity 1 P31040,P21912,P29803 134 6.75e-04 18 4 2 0.500 0.111 REAC:71403 rea 1 Citric acid cycle (TCA cycle) 1 P31040,P21912 134 6.89e-04 95 4 3 0.750 0.032 HP:0010786 hp 1 Urinary tract neoplasm 1 P31040,P21912,Q9NX18 134 7.12e-04 96 4 3 0.750 0.031 HP:0100006 hp 1 Neoplasm of the central nervous system 1 P31040,P21912,Q9NX18 134 7.16e-04 15 4 2 0.500 0.133 HP:0008972 hp 1 Decreased activity of mitochondrial respiratory chain 1 P31040,P21912 134 7.24e-04 85 4 2 0.500 0.024 GO:0006119 BP 1 oxidative phosphorylation 1 P31040,Q9NX18 134 7.57e-04 98 4 3 0.750 0.031 HP:0000739 hp 1 Anxiety 1 P31040,P21912,Q9NX18 134 7.88e-04 1 4 1 0.250 1.000 GO:0018293 BP 1 protein-FAD linkage 1 Q9NX18 134 7.88e-04 1 4 1 0.250 1.000 GO:0008177 MF 1 succinate dehydrogenase (ubiquinone) activity 1 P31040 134 7.88e-04 1 4 1 0.250 1.000 GO:0009061 BP 1 anaerobic respiration 1 P31040 134 7.88e-04 1 4 1 0.250 1.000 GO:0051538 MF 1 3 iron, 4 sulfur cluster binding 1 P21912 134 8.18e-04 16 4 2 0.500 0.125 HP:0011922 hp 1 Abnormal activity of mitochondrial respiratory chain 1 P31040,P21912 134 8.18e-04 16 4 2 0.500 0.125 HP:0012240 hp 1 Increased intramyocellular lipid droplets 1 P31040,P21912 134 8.29e-04 101 4 3 0.750 0.030 HP:0100852 hp 1 Abnormal fear/anxiety-related behavior 1 P31040,P21912,Q9NX18 134 8.86e-04 94 4 2 0.500 0.021 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 P31040,P21912 134 9.27e-04 17 4 2 0.500 0.118 HP:0100743 hp 1 Neoplasm of the rectum 1 P31040,P21912 134 9.85e-04 107 4 3 0.750 0.028 HP:0001649 hp 1 Tachycardia 1 P31040,P21912,Q9NX18 134 1.07e-03 110 4 3 0.750 0.027 HP:0005114 hp 1 Abnormalities of the peripheral arteries 1 P31040,P21912,Q9NX18 134 1.07e-03 110 4 3 0.750 0.027 HP:0100545 hp 1 Arterial stenosis 1 P31040,P21912,Q9NX18 134 1.16e-03 19 4 2 0.500 0.105 HP:0009058 hp 1 Increased muscle lipid content 1 P31040,P21912 134 1.24e-03 111 4 2 0.500 0.018 GO:0098798 CC 1 mitochondrial protein complex 1 P31040,P21912 134 1.39e-03 120 4 3 0.750 0.025 HP:0007379 hp 1 Neoplasm of the genitourinary tract 1 P31040,P21912,Q9NX18 134 1.43e-03 21 4 2 0.500 0.095 HP:0100833 hp 1 Neoplasm of the small intestine 1 P31040,P21912 134 1.46e-03 122 4 3 0.750 0.025 HP:0004375 hp 1 Neoplasm of the nervous system 1 P31040,P21912,Q9NX18 134 1.53e-03 124 4 3 0.750 0.024 HP:0000093 hp 1 Proteinuria 1 P31040,P21912,Q9NX18 134 1.55e-03 650 4 3 0.750 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 P31040,P21912,P29803 134 1.58e-03 2 4 1 0.250 0.500 GO:0004739 MF 1 pyruvate dehydrogenase (acetyl-transferring) activity 1 P29803 134 1.58e-03 2 4 1 0.250 0.500 GO:0048039 MF 1 ubiquinone binding 1 P21912 134 1.58e-03 2 4 1 0.250 0.500 GO:0016635 MF 1 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor 1 P31040 134 1.61e-03 126 4 3 0.750 0.024 HP:0000834 hp 1 Abnormality of the adrenal glands 1 P31040,P21912,Q9NX18 134 1.68e-03 128 4 3 0.750 0.023 HP:0007550 hp 1 Hypohidrosis or hyperhidrosis 1 P31040,P21912,Q9NX18 134 1.75e-03 1 4 1 0.250 1.000 OMIM:614165 omi 1 PARAGANGLIOMAS 5; PGL5 1 P31040 134 1.75e-03 1 4 1 0.250 1.000 OMIM:252011 omi 1 MITOCHONDRIAL COMPLEX II DEFICIENCY;;SUCCINATE CoQ REDUCTASE DEFICIENCY 1 P31040 134 1.75e-03 1 4 1 0.250 1.000 OMIM:601650 omi 1 PARAGANGLIOMAS 2; PGL2;;GLOMUS TUMORS, FAMILIAL, 2 1 Q9NX18 134 1.75e-03 1 4 1 0.250 1.000 OMIM:612359 omi 1 COWDEN SYNDROME 2; CWS2 1 P21912 134 1.75e-03 1 4 1 0.250 1.000 OMIM:115310 omi 1 PARAGANGLIOMAS 4; PGL4;;CAROTID BODY TUMORS AND MULTIPLE EXTRAADRENAL PHEOCHROMOCYTOMAS;;PHEOCHROMOCYTOMA, EXTRAADRENAL, AND CERVICAL PARAGANGLIOMA;;PARAGANGLIOMAS, HEREDITARY EXTRAADRENAL;;PHEOCHROMOCYTOMA, FAMILIAL EXTRAADRENAL;;PARAGANGLIOMA, FAMILIAL MALIGNANT 1 P21912 134 1.75e-03 1 4 1 0.250 1.000 OMIM:613642 omi 1 CARDIOMYOPATHY, DILATED, 1GG; CMD1GG 1 P31040 134 1.76e-03 130 4 3 0.750 0.023 HP:0011028 hp 1 Abnormality of blood circulation 1 P31040,P21912,Q9NX18 134 1.76e-03 130 4 3 0.750 0.023 HP:0011029 hp 1 Internal hemorrhage 1 P31040,P21912,Q9NX18 134 1.76e-03 130 4 3 0.750 0.023 HP:0008046 hp 1 Abnormality of the retinal vasculature 1 P31040,P21912,Q9NX18 134 1.81e-03 653 4 3 0.750 0.005 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 1.87e-03 24 4 2 0.500 0.083 HP:0008316 hp 1 Abnormal mitochondria in muscle tissue 1 P31040,P21912 134 1.99e-03 674 4 3 0.750 0.004 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 2.05e-03 143 4 2 0.500 0.014 GO:0044455 CC 1 mitochondrial membrane part 1 P31040,P21912 134 2.15e-03 139 4 3 0.750 0.022 HP:0008047 hp 1 Abnormality of the vasculature of the eye 1 P31040,P21912,Q9NX18 134 2.15e-03 139 4 3 0.750 0.022 HP:0007378 hp 1 Neoplasm of the gastrointestinal tract 1 P31040,P21912,Q9NX18 134 2.18e-03 729 4 3 0.750 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 P31040,P21912,P29803 134 2.20e-03 140 4 3 0.750 0.021 HP:0000971 hp 1 Abnormality of the sweat gland 1 P31040,P21912,Q9NX18 134 2.27e-03 739 4 3 0.750 0.004 GO:0006082 BP 1 organic acid metabolic process 1 P31040,P21912,P29803 134 2.39e-03 144 4 3 0.750 0.021 HP:0010929 hp 1 Abnormality of cation homeostasis 1 P31040,P21912,Q9NX18 134 2.55e-03 147 4 3 0.750 0.020 HP:0003829 hp 1 Incomplete penetrance 1 P31040,P21912,Q9NX18 134 2.56e-03 28 4 2 0.500 0.071 HP:0001176 hp 1 Large hands 1 P31040,P21912 134 2.80e-03 3 4 1 0.250 0.333 TF:M07139_1 tf 1 Factor: USF2; motif: RYCAYGTGACY; match class: 1 1 P21912 134 2.81e-03 152 4 3 0.750 0.020 HP:0002315 hp 1 Headache 1 P31040,P21912,Q9NX18 134 2.98e-03 155 4 3 0.750 0.019 HP:0001635 hp 1 Congestive heart failure 1 P31040,P21912,Q9NX18 134 3.16e-03 178 4 2 0.500 0.011 GO:0046034 BP 1 ATP metabolic process 1 P31040,Q9NX18 134 3.27e-03 798 4 3 0.750 0.004 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.27e-03 798 4 3 0.750 0.004 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.50e-03 2 4 1 0.250 0.500 OMIM:606864 omi 1 PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA;;CARNEY-STRATAKIS SYNDROME;;PARAGANGLIOMA AND GASTROINTESTINAL STROMAL TUMOR; GIST 1 P21912 134 3.52e-03 164 4 3 0.750 0.018 HP:0003111 hp 1 Abnormality of ion homeostasis 1 P31040,P21912,Q9NX18 134 3.56e-03 189 4 2 0.500 0.011 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P31040,Q9NX18 134 3.57e-03 33 4 2 0.500 0.061 HP:0001025 hp 1 Urticaria 1 P31040,P21912 134 3.60e-03 190 4 2 0.500 0.011 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P31040,Q9NX18 134 3.71e-03 193 4 2 0.500 0.010 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P31040,Q9NX18 134 3.78e-03 838 4 3 0.750 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 3.79e-03 168 4 3 0.750 0.018 HP:0003117 hp 1 Abnormality of circulating hormone level 1 P31040,P21912,Q9NX18 134 3.94e-03 5 4 1 0.250 0.200 GO:0006105 BP 1 succinate metabolic process 1 P31040 134 3.94e-03 5 4 1 0.250 0.200 GO:0048038 MF 1 quinone binding 1 P21912 134 3.99e-03 171 4 3 0.750 0.018 HP:0100659 hp 1 Abnormality of the cerebral vasculature 1 P31040,P21912,Q9NX18 134 4.02e-03 201 4 2 0.500 0.010 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P31040,Q9NX18 134 4.02e-03 201 4 2 0.500 0.010 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P31040,Q9NX18 134 4.10e-03 203 4 2 0.500 0.010 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P31040,Q9NX18 134 4.22e-03 206 4 2 0.500 0.010 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P31040,Q9NX18 134 4.39e-03 210 4 2 0.500 0.010 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P31040,Q9NX18 134 4.51e-03 109 4 2 0.500 0.018 KEGG:00190 keg 1 Oxidative phosphorylation 1 P31040,P21912 134 4.54e-03 46 4 2 0.500 0.043 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 P31040,P21912 134 4.69e-03 902 4 3 0.750 0.003 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 4.72e-03 6 4 1 0.250 0.167 GO:0004738 MF 1 pyruvate dehydrogenase activity 1 P29803 134 4.74e-03 38 4 2 0.500 0.053 HP:0003200 hp 1 Ragged-red muscle fibers 1 P31040,P21912 134 4.75e-03 906 4 3 0.750 0.003 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 4.86e-03 913 4 3 0.750 0.003 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.99e-03 921 4 3 0.750 0.003 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 5.25e-03 3 4 1 0.250 0.333 OMIM:606764 omi 1 GASTROINTESTINAL STROMAL TUMOR; GIST 1 P21912 134 5.28e-03 118 4 2 0.500 0.017 KEGG:05012 keg 1 Parkinson's disease 1 P31040,P21912 134 5.46e-03 2637 4 4 1.000 0.002 TF:M07301_1 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 1 1 P31040,P21912,P29803,Q9NX18 134 5.50e-03 2560 4 4 1.000 0.002 GO:0044710 BP 1 single-organism metabolic process 1 P31040,P21912,P29803,Q9NX18 134 5.59e-03 6 4 1 0.250 0.167 TF:M06588_0 tf 1 Factor: ZNF845; motif: NGGTTAGTCTGA; match class: 0 1 Q9NX18 134 5.72e-03 240 4 2 0.500 0.008 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P31040,Q9NX18 134 5.86e-03 243 4 2 0.500 0.008 GO:0042278 BP 1 purine nucleoside metabolic process 1 P31040,Q9NX18 134 5.92e-03 125 4 2 0.500 0.016 KEGG:04932 keg 1 Non-alcoholic fatty liver disease (NAFLD) 1 P31040,P21912 134 6.07e-03 197 4 3 0.750 0.015 HP:0011792 hp 1 Neoplasm by histology 1 P31040,P21912,Q9NX18 134 6.07e-03 43 4 2 0.500 0.047 HP:0010614 hp 1 Fibroma 1 P31040,P21912 134 6.24e-03 251 4 2 0.500 0.008 GO:0009119 BP 1 ribonucleoside metabolic process 1 P31040,Q9NX18 134 6.25e-03 199 4 3 0.750 0.015 HP:0000822 hp 1 Hypertension 1 P31040,P21912,Q9NX18 134 6.30e-03 8 4 1 0.250 0.125 GO:0051537 MF 1 2 iron, 2 sulfur cluster binding 1 P21912 134 6.30e-03 8 4 1 0.250 0.125 GO:0018065 BP 1 protein-cofactor linkage 1 Q9NX18 134 6.30e-03 8 4 1 0.250 0.125 GO:0016624 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 1 P29803 134 6.65e-03 45 4 2 0.500 0.044 HP:0000988 hp 1 Skin rash 1 P31040,P21912 134 6.65e-03 45 4 2 0.500 0.044 HP:0012316 hp 1 Fibrous tissue neoplasm 1 P31040,P21912 134 6.93e-03 390 4 2 0.500 0.005 MI:hsa-miR-569 mi 1 MI:hsa-miR-569 1 P21912,P29803 134 7.25e-03 47 4 2 0.500 0.043 HP:0100273 hp 1 Neoplasm of the colon 1 P31040,P21912 134 7.64e-03 213 4 3 0.750 0.014 HP:0003581 hp 1 Adult onset 1 P31040,P21912,Q9NX18 134 7.64e-03 213 4 3 0.750 0.014 HP:0000405 hp 1 Conductive hearing impairment 1 P31040,P21912,Q9NX18 134 7.80e-03 281 4 2 0.500 0.007 GO:0009116 BP 1 nucleoside metabolic process 1 P31040,Q9NX18 134 7.82e-03 144 4 2 0.500 0.014 KEGG:05010 keg 1 Alzheimer's disease 1 P31040,P21912 134 7.91e-03 1078 4 3 0.750 0.003 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 8.21e-03 50 4 2 0.500 0.040 HP:0002034 hp 1 Abnormality of the rectum 1 P31040,P21912 134 8.55e-03 1107 4 3 0.750 0.003 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 8.79e-03 2970 4 4 1.000 0.001 TF:M03558_0 tf 1 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 8.82e-03 299 4 2 0.500 0.007 GO:1901657 BP 1 glycosyl compound metabolic process 1 P31040,Q9NX18 134 8.87e-03 1121 4 3 0.750 0.003 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 8.99e-03 302 4 2 0.500 0.007 GO:0005743 CC 1 mitochondrial inner membrane 1 P31040,P21912 134 9.05e-03 303 4 2 0.500 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P31040,Q9NX18 134 9.05e-03 1129 4 3 0.750 0.003 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 9.15e-03 1133 4 3 0.750 0.003 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P31040,P21912,Q9NX18 134 9.29e-03 307 4 2 0.500 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 P31040,Q9NX18 134 1.00e-02 319 4 2 0.500 0.006 GO:0019693 BP 1 ribose phosphate metabolic process 1 P31040,Q9NX18 134 1.02e-02 13 4 1 0.250 0.077 GO:0051539 MF 1 4 iron, 4 sulfur cluster binding 1 P21912 134 1.03e-02 324 4 2 0.500 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 P31040,Q9NX18 134 1.03e-02 166 4 2 0.500 0.012 KEGG:05016 keg 1 Huntington's disease 1 P31040,P21912 134 1.04e-02 325 4 2 0.500 0.006 GO:0019866 CC 1 organelle inner membrane 1 P31040,P21912 134 1.05e-02 6 4 1 0.250 0.167 OMIM:171300 omi 1 PHEOCHROMOCYTOMAPHEOCHROMOCYTOMA, SUSCEPTIBILITY TO 1 P21912 134 1.09e-02 320 4 2 0.500 0.006 TF:M07259_1 tf 1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1 P31040,Q9NX18 134 1.10e-02 58 4 2 0.500 0.034 HP:0005214 hp 1 Intestinal obstruction 1 P31040,P21912 134 1.14e-02 1221 4 3 0.750 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 P31040,P21912,Q9NX18 134 1.14e-02 59 4 2 0.500 0.034 HP:0100834 hp 1 Neoplasm of the large intestine 1 P31040,P21912 134 1.18e-02 15 4 1 0.250 0.067 GO:0010719 BP 1 negative regulation of epithelial to mesenchymal transition 1 Q9NX18 134 1.18e-02 60 4 2 0.500 0.033 HP:0004796 hp 1 Gastrointestinal obstruction 1 P31040,P21912 134 1.18e-02 247 4 3 0.750 0.012 HP:0001608 hp 1 Abnormality of the voice 1 P31040,P21912,Q9NX18 134 1.20e-02 248 4 3 0.750 0.012 HP:0011452 hp 1 Functional abnormality of the middle ear 1 P31040,P21912,Q9NX18 134 1.20e-02 350 4 2 0.500 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 P31040,Q9NX18 134 1.29e-02 1274 4 3 0.750 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.36e-02 259 4 3 0.750 0.012 HP:0011675 hp 1 Arrhythmia 1 P31040,P21912,Q9NX18 134 1.39e-02 1307 4 3 0.750 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.39e-02 1308 4 3 0.750 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.45e-02 1329 4 3 0.750 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.47e-02 388 4 2 0.500 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 P31040,Q9NX18 134 1.48e-02 1337 4 3 0.750 0.002 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P31040,P21912,Q9NX18 134 1.48e-02 375 4 2 0.500 0.005 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P31040,P21912 134 1.49e-02 19 4 1 0.250 0.053 GO:0051536 MF 1 iron-sulfur cluster binding 1 P21912 134 1.49e-02 19 4 1 0.250 0.053 GO:0051540 MF 1 metal cluster binding 1 P21912 134 1.55e-02 398 4 2 0.500 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P31040,Q9NX18 134 1.55e-02 399 4 2 0.500 0.005 GO:0031966 CC 1 mitochondrial membrane 1 P31040,P21912 134 1.56e-02 1360 4 3 0.750 0.002 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.57e-02 386 4 2 0.500 0.005 TF:M00975_1 tf 1 Factor: RFX; motif: SHGTTGCSN; match class: 1 1 P31040,Q9NX18 134 1.59e-02 1446 4 3 0.750 0.002 TF:M07327_1 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 1 1 P31040,P29803,Q9NX18 134 1.61e-02 391 4 2 0.500 0.005 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 P21912,Q9NX18 134 1.62e-02 275 4 3 0.750 0.011 HP:0001892 hp 1 Abnormal bleeding 1 P31040,P21912,Q9NX18 134 1.63e-02 393 4 2 0.500 0.005 HPA:041020_13 hpa 1 spleen; cells in white pulp[Supportive,High] 1 P21912,Q9NX18 134 1.65e-02 71 4 2 0.500 0.028 HP:0006753 hp 1 Neoplasm of the stomach 1 P31040,P21912 134 1.67e-02 3485 4 4 1.000 0.001 TF:M04611_0 tf 1 Factor: FOXM1; motif: NAGASTGATTA; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 1.68e-02 1396 4 3 0.750 0.002 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.74e-02 73 4 2 0.500 0.027 HP:0002352 hp 1 Leukoencephalopathy 1 P31040,P21912 134 1.74e-02 90 4 2 0.500 0.022 REAC:611105 rea 1 Respiratory electron transport 1 P31040,P21912 134 1.77e-02 19 4 1 0.250 0.053 TF:M06631_0 tf 1 Factor: ZNF696; motif: KGTTGCAAAATC; match class: 0 1 Q9NX18 134 1.83e-02 434 4 2 0.500 0.005 GO:0005740 CC 1 mitochondrial envelope 1 P31040,P21912 134 1.86e-02 3580 4 4 1.000 0.001 TF:M01151_0 tf 1 Factor: DMRT7; motif: TTGTTACAWTKTKG; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 1.88e-02 1453 4 3 0.750 0.002 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.91e-02 1459 4 3 0.750 0.002 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P31040,P21912,Q9NX18 134 1.91e-02 444 4 2 0.500 0.005 GO:0098796 CC 1 membrane protein complex 1 P31040,P21912 134 1.95e-02 1470 4 3 0.750 0.002 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 1.96e-02 450 4 2 0.500 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P31040,Q9NX18 134 1.97e-02 1477 4 3 0.750 0.002 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 P31040,P21912,Q9NX18 134 1.99e-02 1480 4 3 0.750 0.002 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.06e-02 1499 4 3 0.750 0.002 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.12e-02 1513 4 3 0.750 0.002 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.12e-02 450 4 2 0.500 0.004 TF:M01744_1 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 1 1 P21912,Q9NX18 134 2.15e-02 1521 4 3 0.750 0.002 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.17e-02 456 4 2 0.500 0.004 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 P31040,Q9NX18 134 2.19e-02 82 4 2 0.500 0.024 HP:0003287 hp 1 Abnormality of mitochondrial metabolism 1 P31040,P21912 134 2.21e-02 1535 4 3 0.750 0.002 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.24e-02 83 4 2 0.500 0.024 HP:0030448 hp 1 Soft tissue sarcoma 1 P31040,P21912 134 2.36e-02 476 4 2 0.500 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P31040,P21912 134 2.37e-02 1574 4 3 0.750 0.002 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.38e-02 1576 4 3 0.750 0.002 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.41e-02 86 4 2 0.500 0.023 HP:0002239 hp 1 Gastrointestinal hemorrhage 1 P31040,P21912 134 2.41e-02 1583 4 3 0.750 0.002 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P31040,P21912,Q9NX18 134 2.43e-02 483 4 2 0.500 0.004 TF:M02273_1 tf 1 Factor: NURR1; motif: AAGGTCAC; match class: 1 1 P31040,P21912 134 2.44e-02 484 4 2 0.500 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P21912,Q9NX18 134 2.44e-02 1589 4 3 0.750 0.002 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.44e-02 1589 4 3 0.750 0.002 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.51e-02 27 4 1 0.250 0.037 TF:M05938_1 tf 1 Factor: ZNF714; motif: NSGKTGGGCCGM; match class: 1 1 Q9NX18 134 2.57e-02 1619 4 3 0.750 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 2.57e-02 89 4 2 0.500 0.022 HP:0003745 hp 1 Sporadic 1 P31040,P21912 134 2.58e-02 1621 4 3 0.750 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P31040,P21912,Q9NX18 134 2.59e-02 1622 4 3 0.750 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.59e-02 1622 4 3 0.750 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P31040,P21912,Q9NX18 134 2.60e-02 110 4 2 0.500 0.018 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P31040,P21912 134 2.61e-02 15 4 1 0.250 0.067 OMIM:256000 omi 1 LEIGH SYNDROME; LS;;NECROTIZING ENCEPHALOPATHY, INFANTILE SUBACUTE, OF LEIGH; SNELEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX II DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX III DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX IV DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX V DEFICIENCY, INCLUDED 1 P31040 134 2.66e-02 3917 4 4 1.000 0.001 TF:M04333_0 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 2.76e-02 1659 4 3 0.750 0.002 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.81e-02 93 4 2 0.500 0.022 HP:0012103 hp 1 Abnormality of the mitochondrion 1 P31040,P21912 134 2.81e-02 1670 4 3 0.750 0.002 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 2.89e-02 3998 4 4 1.000 0.001 TF:M01599_0 tf 1 Factor: FOXP3; motif: RTAAACAA; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 2.95e-02 533 4 2 0.500 0.004 TF:M03791_1 tf 1 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY; match class: 1 1 P29803,Q9NX18 134 2.98e-02 1704 4 3 0.750 0.002 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.00e-02 1707 4 3 0.750 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.04e-02 542 4 2 0.500 0.004 TF:M01877_1 tf 1 Factor: GATA-2; motif: GATAANN; match class: 1 1 P21912,P29803 134 3.07e-02 5 4 1 0.250 0.200 HP:0012844 hp 1 Trichilemmoma 1 P21912 134 3.07e-02 5 4 1 0.250 0.200 HP:0012843 hp 1 Hair follicle neoplasm 1 P21912 134 3.07e-02 5 4 1 0.250 0.200 HP:3000019 hp 1 Abnormality of buccal mucosa 1 P21912 134 3.07e-02 1722 4 3 0.750 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P31040,P21912,Q9NX18 134 3.18e-02 555 4 2 0.500 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 P21912,Q9NX18 134 3.25e-02 1756 4 3 0.750 0.002 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.28e-02 564 4 2 0.500 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 P21912,Q9NX18 134 3.29e-02 42 4 1 0.250 0.024 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P29803 134 3.29e-02 4131 4 4 1.000 0.001 TF:M07287_0 tf 1 Factor: FOXO3A; motif: NNNRTAAACANNN; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 3.30e-02 1765 4 3 0.750 0.002 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.32e-02 1769 4 3 0.750 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.36e-02 102 4 2 0.500 0.020 HP:0003546 hp 1 Exercise intolerance 1 P31040,P21912 134 3.38e-02 1780 4 3 0.750 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.38e-02 354 4 3 0.750 0.008 HP:0000370 hp 1 Abnormality of the middle ear 1 P31040,P21912,Q9NX18 134 3.39e-02 1782 4 3 0.750 0.002 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.42e-02 1788 4 3 0.750 0.002 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.43e-02 103 4 2 0.500 0.019 HP:0000602 hp 1 Ophthalmoplegia 1 P31040,P21912 134 3.46e-02 4184 4 4 1.000 0.001 TF:M00476_0 tf 1 Factor: FOXO4; motif: NNGTTGTTTACNTN; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 3.47e-02 20 4 1 0.250 0.050 OMIM:115200 omi 1 Dilated Cardiomyopathy 1 P31040 134 3.47e-02 1797 4 3 0.750 0.002 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.49e-02 104 4 2 0.500 0.019 HP:0007400 hp 1 Irregular hyperpigmentation 1 P31040,P21912 134 3.50e-02 1803 4 3 0.750 0.002 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.56e-02 1813 4 3 0.750 0.002 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.59e-02 1818 4 3 0.750 0.002 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.60e-02 1820 4 3 0.750 0.002 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.62e-02 1922 4 3 0.750 0.002 TF:M02062_0 tf 1 Factor: Erg; motif: ACCGGAAGTN; match class: 0 1 P21912,P29803,Q9NX18 134 3.63e-02 1825 4 3 0.750 0.002 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.68e-02 6 4 1 0.250 0.167 HP:0000854 hp 1 Thyroid adenoma 1 P21912 134 3.68e-02 6 4 1 0.250 0.167 HP:0012871 hp 1 Varicocele 1 P21912 134 3.68e-02 6 4 1 0.250 0.167 HP:0000131 hp 1 Uterine leiomyoma 1 P21912 134 3.68e-02 6 4 1 0.250 0.167 HP:0010619 hp 1 Fibroadenoma of the breast 1 P21912 134 3.69e-02 107 4 2 0.500 0.019 HP:0000982 hp 1 Palmoplantar keratoderma 1 P31040,P21912 134 3.69e-02 365 4 3 0.750 0.008 HP:0003110 hp 1 Abnormality of urine homeostasis 1 P31040,P21912,Q9NX18 134 3.76e-02 108 4 2 0.500 0.019 HP:0002151 hp 1 Increased serum lactate 1 P31040,P21912 134 3.81e-02 41 4 1 0.250 0.024 TF:M05663_0 tf 1 Factor: ZNF450; motif: NAGGGCCNGCKC; match class: 0 1 P31040 134 3.81e-02 1857 4 3 0.750 0.002 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.85e-02 1863 4 3 0.750 0.002 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 3.92e-02 1975 4 3 0.750 0.002 TF:M07340_1 tf 1 Factor: TEF-1; motif: ACATTCCWSNN; match class: 1 1 P31040,P21912,P29803 134 3.95e-02 1880 4 3 0.750 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.97e-02 1883 4 3 0.750 0.002 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 3.97e-02 111 4 2 0.500 0.018 HP:0009124 hp 1 Abnormality of adipose tissue 1 P31040,P21912 134 3.99e-02 51 4 1 0.250 0.020 GO:0010717 BP 1 regulation of epithelial to mesenchymal transition 1 Q9NX18 134 4.01e-02 1890 4 3 0.750 0.002 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 P31040,P21912,Q9NX18 134 4.06e-02 4354 4 4 1.000 0.001 TF:M04334_1 tf 1 Factor: HMX2; motif: ANCAMTTAANN; match class: 1 1 P31040,P21912,P29803,Q9NX18 134 4.08e-02 44 4 1 0.250 0.023 TF:M04406_0 tf 1 Factor: MSX2; motif: GCAATTAAAWWSCAATTA; match class: 0 1 Q9NX18 134 4.09e-02 1904 4 3 0.750 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.12e-02 1909 4 3 0.750 0.002 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.18e-02 114 4 2 0.500 0.018 HP:0001644 hp 1 Dilated cardiomyopathy 1 P31040,P21912 134 4.18e-02 665 4 2 0.500 0.003 GO:0031967 CC 1 organelle envelope 1 P31040,P21912 134 4.19e-02 53 4 1 0.250 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q9NX18 134 4.21e-02 382 4 3 0.750 0.008 HP:0011004 hp 1 Abnormality of the systemic arterial tree 1 P31040,P21912,Q9NX18 134 4.22e-02 1924 4 3 0.750 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 4.22e-02 668 4 2 0.500 0.003 GO:0031975 CC 1 envelope 1 P31040,P21912 134 4.27e-02 1932 4 3 0.750 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.27e-02 1932 4 3 0.750 0.002 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 4.27e-02 1933 4 3 0.750 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.29e-02 7 4 1 0.250 0.143 HP:0010516 hp 1 Thymus hyperplasia 1 P21912 134 4.29e-02 7 4 1 0.250 0.143 HP:0001140 hp 1 Epibulbar dermoid 1 P21912 134 4.29e-02 7 4 1 0.250 0.143 HP:0100898 hp 1 Connective tissue nevi 1 P21912 134 4.29e-02 7 4 1 0.250 0.143 HP:0009721 hp 1 Shagreen patch 1 P21912 134 4.29e-02 7 4 1 0.250 0.143 HP:0100780 hp 1 Conjunctival hamartoma 1 P21912 134 4.29e-02 674 4 2 0.500 0.003 GO:0044429 CC 1 mitochondrial part 1 P31040,P21912 134 4.29e-02 674 4 2 0.500 0.003 GO:0019637 BP 1 organophosphate metabolic process 1 P31040,Q9NX18 134 4.38e-02 1950 4 3 0.750 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 4.41e-02 658 4 2 0.500 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P21912,Q9NX18 134 4.54e-02 1974 4 3 0.750 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.55e-02 49 4 1 0.250 0.020 TF:M00225_1 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 1 Q9NX18 134 4.61e-02 1986 4 3 0.750 0.002 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.63e-02 1989 4 3 0.750 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.68e-02 1996 4 3 0.750 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.69e-02 1998 4 3 0.750 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P31040,P21912,Q9NX18 134 4.73e-02 51 4 1 0.250 0.020 TF:M04059_0 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 0 1 P29803 134 4.73e-02 51 4 1 0.250 0.020 TF:M04059_1 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 1 1 P29803 134 4.77e-02 122 4 2 0.500 0.016 HP:0001319 hp 1 Neonatal hypotonia 1 P31040,P21912 134 4.87e-02 2024 4 3 0.750 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.88e-02 2026 4 3 0.750 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P31040,P21912,Q9NX18 134 4.92e-02 124 4 2 0.500 0.016 HP:0100242 hp 1 Sarcoma 1 P31040,P21912 134 4.94e-02 4572 4 4 1.000 0.001 TF:M00472_0 tf 1 Factor: FOXO4; motif: RWAAACAANNN; match class: 0 1 P31040,P21912,P29803,Q9NX18 134 4.97e-02 2039 4 3 0.750 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P31040,P21912,Q9NX18 134 5.00e-02 38 4 1 0.250 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P29803 134 5.00e-02 29 4 1 0.250 0.034 OMIM:252010 omi 1 Complex I Deficiency 1 P31040 134 5.00e-02 2151 4 3 0.750 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 P31040,P21912,P29803 135 1.93e-03 3 2 1 0.500 0.333 REAC:77352 rea 1 Beta oxidation of butanoyl-CoA to acetyl-CoA 1 P30084 135 2.11e-03 1 2 1 0.500 1.000 GO:0030731 MF 1 guanidinoacetate N-methyltransferase activity 1 Q14353 135 3.22e-03 5 2 1 0.500 0.200 REAC:77348 rea 1 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1 P30084 135 3.22e-03 5 2 1 0.500 0.200 REAC:77346 rea 1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1 P30084 135 3.22e-03 5 2 1 0.500 0.200 REAC:77310 rea 1 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1 P30084 135 3.22e-03 5 2 1 0.500 0.200 REAC:77350 rea 1 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1 P30084 135 3.87e-03 6 2 1 0.500 0.167 REAC:71288 rea 1 Creatine metabolism 1 Q14353 135 4.03e-03 808 2 2 1.000 0.002 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 P30084,Q14353 135 4.23e-03 2 2 1 0.500 0.500 GO:0006601 BP 1 creatine biosynthetic process 1 Q14353 135 4.87e-03 31 2 1 0.500 0.032 TF:M06548_0 tf 1 Factor: ZNF680; motif: NGNGGTTGTAAA; match class: 0 1 P30084 135 5.15e-03 8 2 1 0.500 0.125 REAC:77286 rea 1 mitochondrial fatty acid beta-oxidation of saturated fatty acids 1 P30084 135 8.29e-03 18 2 1 0.500 0.056 KEGG:00650 keg 1 Butanoate metabolism 1 P30084 135 9.67e-03 21 2 1 0.500 0.048 KEGG:00062 keg 1 Fatty acid elongation 1 P30084 135 1.06e-02 5 2 1 0.500 0.200 GO:0046498 BP 1 S-adenosylhomocysteine metabolic process 1 Q14353 135 1.06e-02 5 2 1 0.500 0.200 GO:0004300 MF 1 enoyl-CoA hydratase activity 1 P30084 135 1.20e-02 26 2 1 0.500 0.038 KEGG:00410 keg 1 beta-Alanine metabolism 1 P30084 135 1.29e-02 20 2 1 0.500 0.050 REAC:77289 rea 1 Mitochondrial Fatty Acid Beta-Oxidation 1 P30084 135 1.38e-02 30 2 1 0.500 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 P30084 135 1.43e-02 31 2 1 0.500 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P30084 135 1.67e-02 1 2 1 0.500 1.000 OMIM:612736 omi 1 CEREBRAL CREATINE DEFICIENCY SYNDROME 2; CCDS2;;GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY;;GAMT DEFICIENCY;;CREATINE DEFICIENCY SYNDROME DUE TO GAMT DEFICIENCY 1 Q14353 135 1.67e-02 1 2 1 0.500 1.000 OMIM:616277 omi 1 MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY; ECHS1D 1 P30084 135 1.69e-02 8 2 1 0.500 0.125 GO:0006600 BP 1 creatine metabolic process 1 Q14353 135 1.70e-02 37 2 1 0.500 0.027 KEGG:00260 keg 1 Glycine, serine and threonine metabolism 1 Q14353 135 1.75e-02 1682 2 2 1.000 0.001 TF:M01778_1 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 1 1 P30084,Q14353 135 1.75e-02 38 2 1 0.500 0.026 KEGG:00071 keg 1 Fatty acid degradation 1 P30084 135 1.81e-02 1712 2 2 1.000 0.001 TF:M01888_1 tf 1 Factor: Smad3; motif: NGNCAGACASNNN; match class: 1 1 P30084,Q14353 135 1.92e-02 123 2 1 0.500 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 Q14353 135 1.97e-02 43 2 1 0.500 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 Q14353 135 2.01e-02 1805 2 2 1.000 0.001 TF:M03824_0 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 0 1 P30084,Q14353 135 2.07e-02 45 2 1 0.500 0.022 KEGG:01212 keg 1 Fatty acid metabolism 1 P30084 135 2.11e-02 46 2 1 0.500 0.022 KEGG:00280 keg 1 Valine, leucine and isoleucine degradation 1 P30084 135 2.13e-02 1857 2 2 1.000 0.001 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 P30084,Q14353 135 2.22e-02 142 2 1 0.500 0.007 TF:M07048_0 tf 1 Factor: MafG; motif: CMATGACTCAGCAGA; match class: 0 1 P30084 135 2.33e-02 11 2 1 0.500 0.091 GO:0046500 BP 1 S-adenosylmethionine metabolic process 1 Q14353 135 2.37e-02 152 2 1 0.500 0.007 TF:M00763_1 tf 1 Factor: PPAR; motif: TGACCTTTGNCCY; match class: 1 1 P30084 135 2.46e-02 1995 2 2 1.000 0.001 TF:M00699_0 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 0 1 P30084,Q14353 135 2.50e-02 136 2 1 0.500 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 P30084 135 2.52e-02 55 2 1 0.500 0.018 KEGG:00310 keg 1 Lysine degradation 1 P30084 135 2.58e-02 165 2 1 0.500 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 Q14353 135 2.75e-02 2111 2 2 1.000 0.001 TF:M01009_0 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 0 1 P30084,Q14353 135 2.83e-02 2140 2 2 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 P30084,Q14353 135 2.87e-02 184 2 1 0.500 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 P30084 135 2.96e-02 190 2 1 0.500 0.005 TF:M01592_1 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 1 Q14353 135 3.03e-02 2215 2 2 1.000 0.001 TF:M07341_1 tf 1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 1 P30084,Q14353 135 3.10e-02 366 2 2 1.000 0.005 MI:hsa-miR-672 mi 1 MI:hsa-miR-672 1 P30084,Q14353 135 3.15e-02 2261 2 2 1.000 0.001 TF:M04004_0 tf 1 Factor: SOX9; motif: NAACAATRN; match class: 0 1 P30084,Q14353 135 3.27e-02 376 2 2 1.000 0.005 MI:hsa-miR-92a-1* mi 1 MI:hsa-miR-92a-1* 1 P30084,Q14353 135 3.29e-02 2310 2 2 1.000 0.001 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 P30084,Q14353 135 3.55e-02 392 2 2 1.000 0.005 MI:hsa-miR-658 mi 1 MI:hsa-miR-658 1 P30084,Q14353 135 3.60e-02 231 2 1 0.500 0.004 TF:M06279_0 tf 1 Factor: ZNF124; motif: WGGCGTCAGA; match class: 0 1 Q14353 135 3.62e-02 396 2 2 1.000 0.005 MI:mmu-miR-688 mi 1 MI:mmu-miR-688 1 P30084,Q14353 135 3.77e-02 242 2 1 0.500 0.004 TF:M01009_1 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 1 1 Q14353 135 3.77e-02 2472 2 2 1.000 0.001 TF:M03557_1 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 1 P30084,Q14353 135 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 Q14353 135 3.80e-02 244 2 1 0.500 0.004 TF:M00514_1 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 1 1 P30084 135 3.81e-02 245 2 1 0.500 0.004 TF:M07235_1 tf 1 Factor: ZEB1; motif: NCWCACCTG; match class: 1 1 P30084 135 3.87e-02 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 P30084,Q14353 135 3.94e-02 253 2 1 0.500 0.004 TF:M01044_0 tf 1 Factor: Tbx5; motif: CTCACACCTT; match class: 0 1 Q14353 135 3.95e-02 2146 2 2 1.000 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 P30084,Q14353 135 4.07e-02 262 2 1 0.500 0.004 TF:M06077_0 tf 1 Factor: ZNF716; motif: NCAGGCARAWCC; match class: 0 1 P30084 135 4.27e-02 2630 2 2 1.000 0.001 TF:M03574_0 tf 1 Factor: GCMa; motif: CCCGCAT; match class: 0 1 P30084,Q14353 135 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 P30084 135 4.46e-02 2689 2 2 1.000 0.001 TF:M06190_1 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 1 1 P30084,Q14353 135 4.46e-02 2689 2 2 1.000 0.001 TF:M06191_1 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 1 1 P30084,Q14353 135 4.47e-02 288 2 1 0.500 0.003 TF:M07394_1 tf 1 Factor: slug; motif: CACCTGNNN; match class: 1 1 Q14353 135 4.77e-02 2781 2 2 1.000 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 P30084,Q14353 135 4.86e-02 23 2 1 0.500 0.043 GO:0042398 BP 1 cellular modified amino acid biosynthetic process 1 Q14353 135 4.87e-02 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 P30084,Q14353 135 4.88e-02 107 2 1 0.500 0.009 KEGG:01200 keg 1 Carbon metabolism 1 P30084 135 4.97e-02 320 2 1 0.500 0.003 TF:M07259_1 tf 1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1 Q14353 135 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 P30084,Q14353 135 5.00e-02 465 2 2 1.000 0.004 MI:hsa-miR-886-5p mi 1 MI:hsa-miR-886-5p 1 P30084,Q14353 135 5.00e-02 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 P30084,Q14353 135 5.00e-02 3 2 1 0.500 0.333 OMIM:300352 omi 1 Cerebral Creatine Deficiency Syndrome 1 Q14353 135 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 P30084,Q14353 135 5.00e-02 1 2 1 0.500 1.000 HP:0007153 hp 1 Progressive extrapyramidal movement disorder 1 Q14353 135 5.00e-02 78 2 1 0.500 0.013 REAC:351202 rea 1 Metabolism of polyamines 1 Q14353 136 3.84e-05 42 2 2 1.000 0.048 GO:0031093 CC 1 platelet alpha granule lumen 1 Q13201,P12259 136 6.87e-05 56 2 2 1.000 0.036 GO:0031091 CC 1 platelet alpha granule 1 Q13201,P12259 136 7.12e-05 57 2 2 1.000 0.035 GO:0034774 CC 1 secretory granule lumen 1 Q13201,P12259 136 1.02e-04 68 2 2 1.000 0.029 GO:0060205 CC 1 cytoplasmic vesicle lumen 1 Q13201,P12259 136 1.05e-04 69 2 2 1.000 0.029 GO:0031983 CC 1 vesicle lumen 1 Q13201,P12259 136 1.34e-04 78 2 2 1.000 0.026 GO:0002576 BP 1 platelet degranulation 1 Q13201,P12259 136 2.84e-04 99 2 2 1.000 0.020 REAC:114608 rea 1 Platelet degranulation 1 Q13201,P12259 136 3.14e-04 104 2 2 1.000 0.019 REAC:76005 rea 1 Response to elevated platelet cytosolic Ca2+ 1 Q13201,P12259 136 5.89e-04 163 2 2 1.000 0.012 GO:0030141 CC 1 secretory granule 1 Q13201,P12259 136 6.48e-04 171 2 2 1.000 0.012 GO:0045055 BP 1 regulated exocytosis 1 Q13201,P12259 136 1.08e-03 221 2 2 1.000 0.009 GO:0007596 BP 1 blood coagulation 1 Q13201,P12259 136 1.10e-03 223 2 2 1.000 0.009 GO:0007599 BP 1 hemostasis 1 Q13201,P12259 136 1.11e-03 224 2 2 1.000 0.009 GO:0099503 CC 1 secretory vesicle 1 Q13201,P12259 136 1.11e-03 224 2 2 1.000 0.009 GO:0050817 BP 1 coagulation 1 Q13201,P12259 136 1.32e-03 244 2 2 1.000 0.008 GO:0006887 BP 1 exocytosis 1 Q13201,P12259 136 1.32e-03 213 2 2 1.000 0.009 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 Q13201,P12259 136 1.60e-03 268 2 2 1.000 0.007 GO:0050878 BP 1 regulation of body fluid levels 1 Q13201,P12259 136 2.00e-03 300 2 2 1.000 0.007 GO:0042060 BP 1 wound healing 1 Q13201,P12259 136 2.04e-03 13 2 1 0.500 0.077 TF:M07306_1 tf 1 Factor: RORalpha; motif: NNWNNAWNTRGGTCAG; match class: 1 1 P12259 136 2.48e-03 334 2 2 1.000 0.006 GO:0009611 BP 1 response to wounding 1 Q13201,P12259 136 4.79e-03 464 2 2 1.000 0.004 GO:0032940 BP 1 secretion by cell 1 Q13201,P12259 136 5.03e-03 903 2 2 1.000 0.002 TF:M04415_1 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 1 1 Q13201,P12259 136 5.08e-03 12 2 1 0.500 0.083 REAC:140875 rea 1 Common Pathway of Fibrin Clot Formation 1 P12259 136 5.36e-03 491 2 2 1.000 0.004 GO:0046903 BP 1 secretion 1 Q13201,P12259 136 5.54e-03 499 2 2 1.000 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q13201,P12259 136 5.77e-03 444 2 2 1.000 0.005 REAC:109582 rea 1 Hemostasis 1 Q13201,P12259 136 7.15e-03 1 2 1 0.500 1.000 OMIM:188055 omi 1 THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE; THPH2;;ACTIVATED PROTEIN C RESISTANCE;;APC RESISTANCE;;THROMBOPHILIA DUE TO DEFICIENCY OF ACTIVATED PROTEIN C COFACTOR;;PROC COFACTOR DEFICIENCY;;PCCF DEFICIENCY;;THROMBOPHILIA VTHROMBOPHILIA DUE TO FACTOR V LEIDEN, INCLUDED 1 P12259 136 7.15e-03 1 2 1 0.500 1.000 OMIM:227400 omi 1 FACTOR V DEFICIENCY;;PARAHEMOPHILIA;;OWREN PARAHEMOPHILIA;;LABILE FACTOR DEFICIENCY 1 P12259 136 7.15e-03 1 2 1 0.500 1.000 OMIM:600880 omi 1 BUDD-CHIARI SYNDROME; BDCHSMEMBRANOUS OBSTRUCTION OF INFERIOR VENA CAVA, INCLUDED; MOVC, INCLUDED 1 P12259 136 7.15e-03 1 2 1 0.500 1.000 OMIM:614389 omi 1 Recurrent Pregnancy Loss 1 P12259 136 7.18e-03 1079 2 2 1.000 0.002 TF:M03884_0 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 0 1 Q13201,P12259 136 9.41e-03 60 2 1 0.500 0.017 TF:M07311_1 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 1 1 P12259 136 9.73e-03 23 2 1 0.500 0.043 REAC:140877 rea 1 Formation of Fibrin Clot (Clotting Cascade) 1 P12259 136 1.00e-02 1 2 1 0.500 1.000 HP:0012175 hp 1 Resistance to activated protein C 1 P12259 136 1.00e-02 1275 2 2 1.000 0.002 TF:M04351_1 tf 1 Factor: HOXC10; motif: GYMATWAAAN; match class: 1 1 Q13201,P12259 136 1.14e-02 1359 2 2 1.000 0.001 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q13201,P12259 136 1.14e-02 27 2 1 0.500 0.037 REAC:5694530 rea 1 Cargo concentration in the ER 1 P12259 136 1.20e-02 1392 2 2 1.000 0.001 TF:M04315_1 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 1 1 Q13201,P12259 136 1.27e-02 81 2 1 0.500 0.012 TF:M06313_0 tf 1 Factor: ZNF678; motif: KGTTAAAAGAGA; match class: 0 1 Q13201 136 1.49e-02 29 2 1 0.500 0.034 GO:0033116 CC 1 endoplasmic reticulum-Golgi intermediate compartment membrane 1 P12259 136 1.80e-02 115 2 1 0.500 0.009 TF:M01826_1 tf 1 Factor: PITX1; motif: GMMACTAATCY; match class: 1 1 P12259 136 1.84e-02 910 2 2 1.000 0.002 GO:0097708 CC 1 intracellular vesicle 1 Q13201,P12259 136 1.92e-02 1765 2 2 1.000 0.001 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q13201,P12259 136 1.93e-02 931 2 2 1.000 0.002 GO:0031410 CC 1 cytoplasmic vesicle 1 Q13201,P12259 136 1.97e-02 126 2 1 0.500 0.008 TF:M00045_0 tf 1 Factor: E4BP4; motif: NRTTAYGTAAYN; match class: 0 1 Q13201 136 1.97e-02 126 2 1 0.500 0.008 TF:M04029_1 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 1 1 Q13201 136 2.00e-02 2 2 1 0.500 0.500 HP:0100602 hp 1 Preeclampsia 1 P12259 136 2.00e-02 1802 2 2 1.000 0.001 TF:M04315_0 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 0 1 Q13201,P12259 136 2.04e-02 958 2 2 1.000 0.002 GO:0016192 BP 1 vesicle-mediated transport 1 Q13201,P12259 136 2.13e-02 136 2 1 0.500 0.007 TF:M00157_1 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 1 1 P12259 136 2.14e-02 3 2 1 0.500 0.333 OMIM:601367 omi 1 STROKE, ISCHEMIC;;CEREBROVASCULAR ACCIDENT;;CEREBRAL INFARCTION 1 P12259 136 2.49e-02 2008 2 2 1.000 0.001 TF:M04442_1 tf 1 Factor: UNCX; motif: NTAATNNAATTAN; match class: 1 1 Q13201,P12259 136 2.53e-02 60 2 1 0.500 0.017 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 P12259 136 2.72e-02 2101 2 2 1.000 0.001 TF:M03793_0 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 0 1 Q13201,P12259 136 2.77e-02 54 2 1 0.500 0.019 GO:0048208 BP 1 COPII vesicle coating 1 P12259 136 2.77e-02 54 2 1 0.500 0.019 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 P12259 136 2.77e-02 54 2 1 0.500 0.019 GO:0030134 CC 1 ER to Golgi transport vesicle 1 P12259 136 2.87e-02 56 2 1 0.500 0.018 GO:0006901 BP 1 vesicle coating 1 P12259 136 2.92e-02 57 2 1 0.500 0.018 GO:0090114 BP 1 COPII-coated vesicle budding 1 P12259 136 2.93e-02 188 2 1 0.500 0.005 TF:M04400_0 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 0 1 P12259 136 2.98e-02 191 2 1 0.500 0.005 TF:M07230_0 tf 1 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG; match class: 0 1 Q13201 136 3.00e-02 2204 2 2 1.000 0.001 TF:M01029_0 tf 1 Factor: TFE; motif: TCATGTGN; match class: 0 1 Q13201,P12259 136 3.00e-02 3 2 1 0.500 0.333 HP:0002639 hp 1 Budd-Chiari syndrome 1 P12259 136 3.00e-02 3 2 1 0.500 0.333 HP:0005542 hp 1 Prolonged whole-blood clotting time 1 P12259 136 3.00e-02 3 2 1 0.500 0.333 HP:0003225 hp 1 Reduced factor V activity 1 P12259 136 3.00e-02 3 2 1 0.500 0.333 HP:0030780 hp 1 Abnormality of the protein C anticoagulant pathway 1 P12259 136 3.03e-02 59 2 1 0.500 0.017 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 P12259 136 3.09e-02 2236 2 2 1.000 0.001 TF:M04344_1 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 1 1 Q13201,P12259 136 3.14e-02 2257 2 2 1.000 0.001 TF:M04075_1 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 1 1 Q13201,P12259 136 3.17e-02 2267 2 2 1.000 0.001 TF:M07390_1 tf 1 Factor: Nfe2l1; motif: TGYNNAGTCATT; match class: 1 1 Q13201,P12259 136 3.18e-02 2270 2 2 1.000 0.001 TF:M01739_0 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 0 1 Q13201,P12259 136 3.18e-02 62 2 1 0.500 0.016 GO:0005793 CC 1 endoplasmic reticulum-Golgi intermediate compartment 1 P12259 136 3.36e-02 2334 2 2 1.000 0.001 TF:M04403_1 tf 1 Factor: MNX1; motif: NNYAATTAAN; match class: 1 1 Q13201,P12259 136 3.38e-02 217 2 1 0.500 0.005 TF:M05956_1 tf 1 Factor: CTIP-2; motif: RTMGTACAA; match class: 1 1 P12259 136 3.41e-02 219 2 1 0.500 0.005 TF:M04011_1 tf 1 Factor: HSFY1; motif: TTCGAANNRTTCGAA; match class: 1 1 Q13201 136 3.44e-02 67 2 1 0.500 0.015 GO:0006903 BP 1 vesicle targeting 1 P12259 136 3.57e-02 2405 2 2 1.000 0.001 TF:M04071_0 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 0 1 Q13201,P12259 136 3.58e-02 230 2 1 0.500 0.004 TF:M07298_0 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 0 1 Q13201 136 3.66e-02 235 2 1 0.500 0.004 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 Q13201 136 3.67e-02 236 2 1 0.500 0.004 TF:M04427_1 tf 1 Factor: PHOX2B; motif: TAATYYAATTA; match class: 1 1 Q13201 136 3.75e-02 241 2 1 0.500 0.004 TF:M04308_1 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 1 1 Q13201 136 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 Q13201 136 3.82e-02 2487 2 2 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q13201,P12259 136 3.82e-02 2487 2 2 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q13201,P12259 136 3.82e-02 2487 2 2 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q13201,P12259 136 3.92e-02 2521 2 2 1.000 0.001 TF:M05883_0 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 0 1 Q13201,P12259 136 3.94e-02 2526 2 2 1.000 0.001 TF:M04446_1 tf 1 Factor: VAX1; motif: YTAATTAN; match class: 1 1 Q13201,P12259 136 4.12e-02 265 2 1 0.500 0.004 TF:M04426_1 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 1 1 Q13201 136 4.20e-02 2609 2 2 1.000 0.001 TF:M00290_0 tf 1 Factor: Freac-2; motif: NNANNGTAAACAANNN; match class: 0 1 Q13201,P12259 136 4.26e-02 2626 2 2 1.000 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q13201,P12259 136 4.34e-02 279 2 1 0.500 0.004 TF:M04290_0 tf 1 Factor: BARX1; motif: CNATTAAAWANCNATTA; match class: 0 1 Q13201 136 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 Q13201,P12259 136 4.46e-02 287 2 1 0.500 0.003 TF:M04381_1 tf 1 Factor: ISX; motif: NYAATTAN; match class: 1 1 Q13201 136 4.46e-02 287 2 1 0.500 0.003 TF:M04416_1 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 1 1 Q13201 136 4.47e-02 2690 2 2 1.000 0.001 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 Q13201,P12259 136 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 P12259 136 4.59e-02 2727 2 2 1.000 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 Q13201,P12259 136 4.66e-02 2749 2 2 1.000 0.001 TF:M04347_1 tf 1 Factor: HOXB2; motif: NNTMATTANN; match class: 1 1 Q13201,P12259 136 4.77e-02 2781 2 2 1.000 0.001 TF:M07421_1 tf 1 Factor: HOXC-8; motif: GAATWAYARN; match class: 1 1 Q13201,P12259 136 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q13201,P12259 136 4.92e-02 96 2 1 0.500 0.010 GO:0006900 BP 1 membrane budding 1 P12259 136 4.95e-02 319 2 1 0.500 0.003 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 P12259 136 4.97e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 Q13201,P12259 136 5.00e-02 2846 2 2 1.000 0.001 TF:M04392_1 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 1 1 Q13201,P12259 136 5.00e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 Q13201,P12259 136 5.00e-02 7 2 1 0.500 0.143 OMIM:188050 omi 1 Thrombophilia 1 P12259 136 5.00e-02 5 2 1 0.500 0.200 HP:0100724 hp 1 Hypercoagulability 1 P12259 136 5.00e-02 48 2 1 0.500 0.021 KEGG:04610 keg 1 Complement and coagulation cascades 1 P12259 136 5.00e-02 5 2 1 0.500 0.200 HP:0100603 hp 1 Toxemia of pregnancy 1 P12259 136 5.00e-02 119 2 1 0.500 0.008 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 P12259 137 4.26e-10 15 8 4 0.500 0.267 GO:0005662 CC 1 DNA replication factor A complex 1 P35244,P15927,P27694,Q13156 137 2.43e-09 45 8 5 0.625 0.111 KEGG:03420 keg 1 Nucleotide excision repair 1 P35244,P15927,P27694,P50613,Q13156 137 3.70e-09 217 8 6 0.750 0.028 GO:0006260 BP 1 DNA replication 1 P35244,Q00059,P15927,Q86UA6,P27694,Q13156 137 4.65e-09 26 8 4 0.500 0.154 GO:0043601 CC 1 nuclear replisome 1 P35244,P15927,P27694,Q13156 137 5.46e-09 27 8 4 0.500 0.148 GO:0030894 CC 1 replisome 1 P35244,P15927,P27694,Q13156 137 6.37e-09 28 8 4 0.500 0.143 GO:0006294 BP 1 nucleotide-excision repair, preincision complex assembly 1 P35244,P15927,P27694,P50613 137 1.13e-08 107 8 5 0.625 0.047 GO:0006289 BP 1 nucleotide-excision repair 1 P35244,P15927,P27694,P50613,Q13156 137 2.24e-08 23 8 4 0.500 0.174 KEGG:03430 keg 1 Mismatch repair 1 P35244,P15927,P27694,Q13156 137 2.83e-08 40 8 4 0.500 0.100 GO:0043596 CC 1 nuclear replication fork 1 P35244,P15927,P27694,Q13156 137 3.11e-08 3 8 3 0.375 1.000 CORUM:5229 cor 1 RPA complex 1 P35244,P15927,P27694 137 3.25e-08 31 8 4 0.500 0.129 REAC:68962 rea 1 Activation of the pre-replicative complex 1 P35244,P15927,P27694,Q13156 137 5.43e-08 670 8 7 0.875 0.010 GO:0006259 BP 1 DNA metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 8.55e-08 115 8 5 0.625 0.043 REAC:69206 rea 1 G1/S Transition 1 P35244,P15927,P27694,P50613,Q13156 137 1.13e-07 56 8 4 0.500 0.071 GO:0005657 CC 1 replication fork 1 P35244,P15927,P27694,Q13156 137 1.14e-07 384 8 6 0.750 0.016 GO:0006281 BP 1 DNA repair 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 1.15e-07 42 8 4 0.500 0.095 REAC:5696395 rea 1 Formation of Incision Complex in GG-NER 1 P35244,P15927,P27694,P50613 137 1.47e-07 178 8 5 0.625 0.028 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P35244,P15927,P27694,P50613,Q13156 137 1.48e-07 36 8 4 0.500 0.111 KEGG:03030 keg 1 DNA replication 1 P35244,P15927,P27694,Q13156 137 1.79e-07 185 8 5 0.625 0.027 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P35244,P15927,P27694,P50613,Q13156 137 1.80e-07 10 8 3 0.375 0.300 REAC:174437 rea 1 Removal of the Flap Intermediate from the C-strand 1 P35244,P15927,P27694 137 2.14e-07 138 8 5 0.625 0.036 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P35244,P15927,P27694,P50613,Q13156 137 2.29e-07 40 8 4 0.500 0.100 KEGG:03440 keg 1 Homologous recombination 1 P35244,P15927,P27694,Q13156 137 2.48e-07 11 8 3 0.375 0.273 REAC:174414 rea 1 Processive synthesis on the C-strand of the telomere 1 P35244,P15927,P27694 137 2.82e-07 70 8 4 0.500 0.057 GO:0003697 MF 1 single-stranded DNA binding 1 P35244,P15927,P27694,Q13156 137 3.16e-07 72 8 4 0.500 0.056 GO:0006283 BP 1 transcription-coupled nucleotide-excision repair 1 P35244,P15927,P27694,P50613 137 3.34e-07 73 8 4 0.500 0.055 GO:0032993 CC 1 protein-DNA complex 1 P35244,P15927,P27694,Q13156 137 3.72e-07 45 8 4 0.500 0.089 KEGG:03460 keg 1 Fanconi anemia pathway 1 P35244,P15927,P27694,Q13156 137 5.46e-07 14 8 3 0.375 0.214 REAC:69166 rea 1 Removal of the Flap Intermediate 1 P35244,P15927,P27694 137 5.46e-07 14 8 3 0.375 0.214 REAC:5358565 rea 1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1 P35244,P15927,P27694 137 5.46e-07 14 8 3 0.375 0.214 REAC:5358606 rea 1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1 P35244,P15927,P27694 137 5.86e-07 18 8 3 0.375 0.167 GO:0042276 BP 1 error-prone translesion synthesis 1 P35244,P15927,P27694 137 5.86e-07 18 8 3 0.375 0.167 GO:0070987 BP 1 error-free translesion synthesis 1 P35244,P15927,P27694 137 6.06e-07 63 8 4 0.500 0.063 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 P35244,P15927,P27694,P50613 137 6.20e-07 6 8 3 0.375 0.500 CORUM:2222 cor 1 BLM complex II 1 P35244,P15927,P27694 137 6.20e-07 6 8 3 0.375 0.500 CORUM:2738 cor 1 BLM complex II 1 P35244,P15927,P27694 137 6.46e-07 64 8 4 0.500 0.062 REAC:6782135 rea 1 Dual incision in TC-NER 1 P35244,P15927,P27694,P50613 137 6.82e-07 15 8 3 0.375 0.200 REAC:110312 rea 1 Translesion synthesis by REV1 1 P35244,P15927,P27694 137 6.82e-07 15 8 3 0.375 0.200 REAC:69183 rea 1 Processive synthesis on the lagging strand 1 P35244,P15927,P27694 137 6.82e-07 15 8 3 0.375 0.200 REAC:5358508 rea 1 Mismatch Repair 1 P35244,P15927,P27694 137 8.39e-07 16 8 3 0.375 0.188 REAC:5655862 rea 1 Translesion synthesis by POLK 1 P35244,P15927,P27694 137 8.39e-07 16 8 3 0.375 0.188 REAC:5656121 rea 1 Translesion synthesis by POLI 1 P35244,P15927,P27694 137 9.55e-07 21 8 3 0.375 0.143 GO:0006295 BP 1 nucleotide-excision repair, DNA incision, 3'-to lesion 1 P35244,P15927,P27694 137 9.55e-07 21 8 3 0.375 0.143 GO:0006293 BP 1 nucleotide-excision repair, preincision complex stabilization 1 P35244,P15927,P27694 137 1.22e-06 18 8 3 0.375 0.167 REAC:110320 rea 1 Translesion Synthesis by POLH 1 P35244,P15927,P27694 137 1.27e-06 23 8 3 0.375 0.130 GO:0006297 BP 1 nucleotide-excision repair, DNA gap filling 1 P35244,P15927,P27694 137 1.37e-06 77 8 4 0.500 0.052 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 P35244,P15927,P27694,P50613 137 1.51e-06 592 8 6 0.750 0.010 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 1.71e-06 20 8 3 0.375 0.150 REAC:69186 rea 1 Lagging Strand Synthesis 1 P35244,P15927,P27694 137 1.73e-06 8 8 3 0.375 0.375 CORUM:248 cor 1 BRAFT complex 1 P35244,P15927,P27694 137 1.85e-06 83 8 4 0.500 0.048 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 P35244,P15927,P27694,P50613 137 1.85e-06 83 8 4 0.500 0.048 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 P35244,P15927,P27694,Q13156 137 1.85e-06 83 8 4 0.500 0.048 REAC:68874 rea 1 M/G1 Transition 1 P35244,P15927,P27694,Q13156 137 1.99e-06 21 8 3 0.375 0.143 REAC:5651801 rea 1 PCNA-Dependent Long Patch Base Excision Repair 1 P35244,P15927,P27694 137 2.41e-06 119 8 4 0.500 0.034 GO:0006261 BP 1 DNA-dependent DNA replication 1 Q00059,Q86UA6,P27694,Q13156 137 2.62e-06 29 8 3 0.375 0.103 GO:0006298 BP 1 mismatch repair 1 P35244,P15927,P27694 137 2.91e-06 30 8 3 0.375 0.100 GO:0042769 BP 1 DNA damage response, detection of DNA damage 1 P35244,P15927,P27694 137 3.02e-06 24 8 3 0.375 0.125 REAC:110373 rea 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 P35244,P15927,P27694 137 3.02e-06 24 8 3 0.375 0.125 REAC:174417 rea 1 Telomere C-strand (Lagging Strand) Synthesis 1 P35244,P15927,P27694 137 3.02e-06 24 8 3 0.375 0.125 REAC:5696397 rea 1 Gap-filling DNA repair synthesis and ligation in GG-NER 1 P35244,P15927,P27694 137 3.22e-06 31 8 3 0.375 0.097 GO:0000722 BP 1 telomere maintenance via recombination 1 P35244,P15927,P27694 137 3.43e-06 25 8 3 0.375 0.120 REAC:3371511 rea 1 HSF1 activation 1 P35244,P15927,P27694 137 3.55e-06 32 8 3 0.375 0.094 GO:0006284 BP 1 base-excision repair 1 P35244,P15927,P27694 137 3.69e-06 10 8 3 0.375 0.300 CORUM:244 cor 1 BRAFT complex 1 P35244,P15927,P27694 137 3.88e-06 134 8 4 0.500 0.030 GO:0065004 BP 1 protein-DNA complex assembly 1 P35244,P15927,P27694,P50613 137 4.88e-06 28 8 3 0.375 0.107 REAC:110314 rea 1 Recognition of DNA damage by PCNA-containing replication complex 1 P35244,P15927,P27694 137 4.96e-06 106 8 4 0.500 0.038 REAC:69306 rea 1 DNA Replication 1 P35244,P15927,P27694,Q13156 137 5.10e-06 36 8 3 0.375 0.083 GO:0006296 BP 1 nucleotide-excision repair, DNA incision, 5'-to lesion 1 P35244,P15927,P27694 137 5.44e-06 29 8 3 0.375 0.103 REAC:6783310 rea 1 Fanconi Anemia Pathway 1 P35244,P15927,P27694 137 5.44e-06 29 8 3 0.375 0.103 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 P35244,P15927,P27694 137 5.55e-06 109 8 4 0.500 0.037 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P35244,P15927,P27694,P50613 137 5.55e-06 37 8 3 0.375 0.081 GO:0019985 BP 1 translesion synthesis 1 P35244,P15927,P27694 137 6.02e-06 38 8 3 0.375 0.079 GO:0033683 BP 1 nucleotide-excision repair, DNA incision 1 P35244,P15927,P27694 137 6.02e-06 38 8 3 0.375 0.079 GO:0036297 BP 1 interstrand cross-link repair 1 P35244,P15927,P27694 137 6.04e-06 30 8 3 0.375 0.100 REAC:180786 rea 1 Extension of Telomeres 1 P35244,P15927,P27694 137 7.31e-06 157 8 4 0.500 0.025 GO:0071824 BP 1 protein-DNA complex subunit organization 1 P35244,P15927,P27694,P50613 137 7.37e-06 32 8 3 0.375 0.094 REAC:69190 rea 1 DNA strand elongation 1 P35244,P15927,P27694 137 7.88e-06 160 8 4 0.500 0.025 GO:0006310 BP 1 DNA recombination 1 P35244,P15927,Q86UA6,P27694 137 8.76e-06 13 8 3 0.375 0.231 CORUM:1005 cor 1 RC complex during G2/M-phase of cell cycle 1 P35244,P15927,P27694 137 8.76e-06 13 8 3 0.375 0.231 CORUM:1004 cor 1 RC complex during S-phase of cell cycle 1 P35244,P15927,P27694 137 8.80e-06 43 8 3 0.375 0.070 GO:0006312 BP 1 mitotic recombination 1 P35244,P15927,P27694 137 9.47e-06 411 8 5 0.625 0.012 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P35244,P15927,P27694,P50613,Q13156 137 9.71e-06 35 8 3 0.375 0.086 REAC:73884 rea 1 Base Excision Repair 1 P35244,P15927,P27694 137 9.71e-06 35 8 3 0.375 0.086 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 P35244,P15927,P27694 137 9.90e-06 126 8 4 0.500 0.032 REAC:69242 rea 1 S Phase 1 P35244,P15927,P27694,P50613 137 1.06e-05 36 8 3 0.375 0.083 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 P35244,P15927,P27694 137 1.06e-05 36 8 3 0.375 0.083 REAC:176187 rea 1 Activation of ATR in response to replication stress 1 P35244,P15927,P27694 137 1.06e-05 36 8 3 0.375 0.083 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 P35244,P15927,P27694 137 1.12e-05 425 8 5 0.625 0.012 GO:0044770 BP 1 cell cycle phase transition 1 P35244,P15927,P27694,P50613,Q13156 137 1.23e-05 48 8 3 0.375 0.062 GO:0006301 BP 1 postreplication repair 1 P35244,P15927,P27694 137 1.25e-05 38 8 3 0.375 0.079 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 P35244,P15927,P27694 137 1.31e-05 49 8 3 0.375 0.061 GO:0003684 MF 1 damaged DNA binding 1 P35244,P15927,P27694 137 1.46e-05 40 8 3 0.375 0.075 REAC:5696400 rea 1 Dual Incision in GG-NER 1 P35244,P15927,P27694 137 1.58e-05 41 8 3 0.375 0.073 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 P35244,P15927,P27694 137 1.58e-05 41 8 3 0.375 0.073 REAC:912446 rea 1 Meiotic recombination 1 P35244,P15927,P27694 137 1.96e-05 44 8 3 0.375 0.068 REAC:73893 rea 1 DNA Damage Bypass 1 P35244,P15927,P27694 137 3.07e-05 51 8 3 0.375 0.059 REAC:157579 rea 1 Telomere Maintenance 1 P35244,P15927,P27694 137 3.39e-05 67 8 3 0.375 0.045 GO:0000731 BP 1 DNA synthesis involved in DNA repair 1 P35244,P15927,P27694 137 4.21e-05 72 8 3 0.375 0.042 GO:0000725 BP 1 recombinational repair 1 P35244,P15927,P27694 137 4.21e-05 72 8 3 0.375 0.042 GO:0000724 BP 1 double-strand break repair via homologous recombination 1 P35244,P15927,P27694 137 4.39e-05 73 8 3 0.375 0.041 GO:1900034 BP 1 regulation of cellular response to heat 1 P35244,P15927,P27694 137 5.27e-05 61 8 3 0.375 0.049 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 P35244,P15927,P27694 137 6.94e-05 85 8 3 0.375 0.035 GO:0034605 BP 1 cellular response to heat 1 P35244,P15927,P27694 137 7.27e-05 448 8 5 0.625 0.011 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P35244,P15927,P27694,P50613,Q13156 137 7.31e-05 68 8 3 0.375 0.044 REAC:1500620 rea 1 Meiosis 1 P35244,P15927,P27694 137 8.68e-05 72 8 3 0.375 0.042 REAC:69473 rea 1 G2/M DNA damage checkpoint 1 P35244,P15927,P27694 137 9.43e-05 74 8 3 0.375 0.041 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 P35244,P15927,P27694 137 9.44e-05 657 8 5 0.625 0.008 GO:1903047 BP 1 mitotic cell cycle process 1 P35244,P15927,P27694,P50613,Q13156 137 9.81e-05 75 8 3 0.375 0.040 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 P35244,P15927,P27694 137 1.02e-04 1212 8 6 0.750 0.005 GO:0033554 BP 1 cellular response to stress 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 1.10e-04 78 8 3 0.375 0.038 REAC:73886 rea 1 Chromosome Maintenance 1 P35244,P15927,P27694 137 1.13e-04 100 8 3 0.375 0.030 GO:0009408 BP 1 response to heat 1 P35244,P15927,P27694 137 1.19e-04 5 8 2 0.250 0.400 CORUM:5231 cor 1 53BP1-containing complex 1 P15927,P27694 137 1.46e-04 109 8 3 0.375 0.028 GO:0000723 BP 1 telomere maintenance 1 P35244,P15927,P27694 137 1.48e-04 86 8 3 0.375 0.035 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 P35244,P15927,P27694 137 1.48e-04 721 8 5 0.625 0.007 GO:0000278 BP 1 mitotic cell cycle 1 P35244,P15927,P27694,P50613,Q13156 137 1.51e-04 110 8 3 0.375 0.027 GO:0032200 BP 1 telomere organization 1 P35244,P15927,P27694 137 1.75e-04 91 8 3 0.375 0.033 REAC:3371556 rea 1 Cellular response to heat stress 1 P35244,P15927,P27694 137 1.76e-04 116 8 3 0.375 0.026 GO:0090305 BP 1 nucleic acid phosphodiester bond hydrolysis 1 P35244,P15927,P27694 137 1.89e-04 357 8 4 0.500 0.011 GO:0044454 CC 1 nuclear chromosome part 1 P35244,P15927,P27694,Q13156 137 1.90e-04 119 8 3 0.375 0.025 GO:0009266 BP 1 response to temperature stimulus 1 P35244,P15927,P27694 137 1.91e-04 547 8 5 0.625 0.009 REAC:1640170 rea 1 Cell Cycle 1 P35244,P15927,P27694,P50613,Q13156 137 2.07e-04 272 8 4 0.500 0.015 REAC:73894 rea 1 DNA Repair 1 P35244,P15927,P27694,P50613 137 2.25e-04 99 8 3 0.375 0.030 REAC:69239 rea 1 Synthesis of DNA 1 P35244,P15927,P27694 137 2.48e-04 383 8 4 0.500 0.010 GO:0000228 CC 1 nuclear chromosome 1 P35244,P15927,P27694,Q13156 137 2.61e-04 104 8 3 0.375 0.029 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 P35244,P15927,P27694 137 3.03e-04 139 8 3 0.375 0.022 GO:1901796 BP 1 regulation of signal transduction by p53 class mediator 1 P35244,P15927,P27694 137 3.08e-04 110 8 3 0.375 0.027 REAC:5693538 rea 1 Homology Directed Repair 1 P35244,P15927,P27694 137 3.09e-04 140 8 3 0.375 0.021 GO:0071897 BP 1 DNA biosynthetic process 1 P35244,P15927,P27694 137 3.16e-04 141 8 3 0.375 0.021 GO:0051606 BP 1 detection of stimulus 1 P35244,P15927,P27694 137 3.29e-04 143 8 3 0.375 0.021 GO:0031334 BP 1 positive regulation of protein complex assembly 1 P35244,P15927,P27694 137 4.10e-04 154 8 3 0.375 0.019 GO:0006302 BP 1 double-strand break repair 1 P35244,P15927,P27694 137 4.43e-04 331 8 4 0.500 0.012 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 P35244,P15927,P27694,P50613 137 4.86e-04 922 8 5 0.625 0.005 GO:0003677 MF 1 DNA binding 1 P35244,Q00059,P15927,P27694,Q13156 137 5.66e-04 952 8 5 0.625 0.005 GO:0022402 BP 1 cell cycle process 1 P35244,P15927,P27694,P50613,Q13156 137 5.90e-04 137 8 3 0.375 0.022 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 P35244,P15927,P27694 137 6.69e-04 143 8 3 0.375 0.021 REAC:69481 rea 1 G2/M Checkpoints 1 P35244,P15927,P27694 137 7.70e-04 150 8 3 0.375 0.020 REAC:5633007 rea 1 Regulation of TP53 Activity 1 P35244,P15927,P27694 137 8.76e-04 199 8 3 0.375 0.015 GO:0060249 BP 1 anatomical structure homeostasis 1 P35244,P15927,P27694 137 9.55e-04 2770 8 7 0.875 0.003 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 9.70e-04 206 8 3 0.375 0.015 GO:0072331 BP 1 signal transduction by p53 class mediator 1 P35244,P15927,P27694 137 1.12e-03 565 8 4 0.500 0.007 GO:0044427 CC 1 chromosomal part 1 P35244,P15927,P27694,Q13156 137 1.19e-03 174 8 3 0.375 0.017 REAC:69620 rea 1 Cell Cycle Checkpoints 1 P35244,P15927,P27694 137 1.21e-03 2869 8 7 0.875 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 1.27e-03 1128 8 5 0.625 0.004 GO:0007049 BP 1 cell cycle 1 P35244,P15927,P27694,P50613,Q13156 137 1.32e-03 229 8 3 0.375 0.013 GO:0043254 BP 1 regulation of protein complex assembly 1 P35244,P15927,P27694 137 1.50e-03 609 8 4 0.500 0.007 GO:0005694 CC 1 chromosome 1 P35244,P15927,P27694,Q13156 137 1.61e-03 1960 8 6 0.750 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 P35244,Q00059,P15927,Q86UA6,P27694,Q13156 137 1.61e-03 1960 8 6 0.750 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P35244,Q00059,P15927,Q86UA6,P27694,Q13156 137 1.68e-03 3013 8 7 0.875 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 1.74e-03 51 8 2 0.250 0.039 GO:0006360 BP 1 transcription from RNA polymerase I promoter 1 Q00059,P50613 137 1.81e-03 52 8 2 0.250 0.038 GO:0016605 CC 1 PML body 1 P15927,P27694 137 2.01e-03 264 8 3 0.375 0.011 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 P35244,P15927,P27694 137 2.20e-03 2071 8 6 0.750 0.003 GO:0006950 BP 1 response to stress 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 2.40e-03 689 8 4 0.500 0.006 GO:0034622 BP 1 cellular macromolecular complex assembly 1 P35244,P15927,P27694,P50613 137 3.05e-03 2173 8 7 0.875 0.003 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 P35244,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 3.09e-03 2177 8 7 0.875 0.003 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P35244,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 4.10e-03 3443 8 7 0.875 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 4.56e-03 3499 8 7 0.875 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 4.57e-03 2 8 1 0.125 0.500 GO:0070363 MF 1 mitochondrial light strand promoter sense binding 1 Q00059 137 4.83e-03 3559 8 8 1.000 0.002 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 5.04e-03 628 8 4 0.500 0.006 REAC:212436 rea 1 Generic Transcription Pathway 1 P35244,P15927,P27694,P50613 137 5.06e-03 3554 8 7 0.875 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.13e-03 3561 8 7 0.875 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.13e-03 3561 8 7 0.875 0.002 GO:0043233 CC 1 organelle lumen 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.13e-03 3561 8 7 0.875 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.13e-03 3561 8 7 0.875 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.20e-03 3569 8 7 0.875 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 5.62e-03 376 8 3 0.375 0.008 GO:0045786 BP 1 negative regulation of cell cycle 1 P15927,P50613,Q13156 137 5.62e-03 3 8 1 0.125 0.333 REAC:163282 rea 1 Mitochondrial transcription initiation 1 Q00059 137 5.72e-03 3620 8 7 0.875 0.002 GO:0009058 BP 1 biosynthetic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 6.39e-03 3681 8 7 0.875 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 6.64e-03 100 8 2 0.250 0.020 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 P15927,P27694 137 6.86e-03 3 8 1 0.125 0.333 GO:0006391 BP 1 transcription initiation from mitochondrial promoter 1 Q00059 137 6.91e-03 404 8 3 0.375 0.007 GO:0080135 BP 1 regulation of cellular response to stress 1 P35244,P15927,P27694 137 7.49e-03 4 8 1 0.125 0.250 REAC:75944 rea 1 Transcription from mitochondrial promoters 1 Q00059 137 7.82e-03 2 8 1 0.125 0.500 CORUM:1007 cor 1 CAK core complex (Cdk-activating kinase core complex) 1 P50613 137 8.19e-03 98 8 2 0.250 0.020 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 Q00059,P50613 137 8.31e-03 112 8 2 0.250 0.018 GO:0000781 CC 1 chromosome, telomeric region 1 P15927,P27694 137 9.17e-03 446 8 3 0.375 0.007 GO:0051276 BP 1 chromosome organization 1 P35244,P15927,P27694 137 1.01e-02 3948 8 7 0.875 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 1.03e-02 125 8 2 0.250 0.016 GO:0000077 BP 1 DNA damage checkpoint 1 P15927,Q13156 137 1.11e-02 378 8 3 0.375 0.008 REAC:2262752 rea 1 Cellular responses to stress 1 P35244,P15927,P27694 137 1.17e-02 1025 8 5 0.625 0.005 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 P35244,P15927,P27694,P50613,Q96FZ2 137 1.17e-02 3 8 1 0.125 0.333 CORUM:1010 cor 1 CAK complex (Cdk-activating kinase complex) 1 P50613 137 1.17e-02 3 8 1 0.125 0.333 CORUM:1008 cor 1 CAK complex (Cdk-activating kinase complex) 1 P50613 137 1.17e-02 3 8 1 0.125 0.333 CORUM:997 cor 1 KIN17-PCNA-RPA70 complex 1 P27694 137 1.20e-02 135 8 2 0.250 0.015 GO:0031570 BP 1 DNA integrity checkpoint 1 P15927,Q13156 137 1.30e-02 504 8 3 0.375 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 P35244,P15927,P27694 137 1.41e-02 519 8 3 0.375 0.006 GO:0009628 BP 1 response to abiotic stimulus 1 P35244,P15927,P27694 137 1.43e-02 521 8 3 0.375 0.006 GO:0044451 CC 1 nucleoplasm part 1 P15927,P27694,P50613 137 1.45e-02 1113 8 4 0.500 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 P35244,P15927,P27694,P50613 137 1.52e-02 2931 8 6 0.750 0.002 GO:0031981 CC 1 nuclear lumen 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 1.55e-02 1804 8 6 0.750 0.003 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q00059,P15927,P27694,P50613,Q96FZ2,Q13156 137 1.56e-02 4 8 1 0.125 0.250 CORUM:1030 cor 1 CAK-ERCC2 complex 1 P50613 137 1.56e-02 4 8 1 0.125 0.250 CORUM:2660 cor 1 ERCC2/CAK complex 1 P50613 137 1.68e-02 4264 8 7 0.875 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 1.70e-02 4163 8 8 1.000 0.002 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 1.90e-02 171 8 2 0.250 0.012 GO:0006352 BP 1 DNA-templated transcription, initiation 1 Q00059,P50613 137 1.91e-02 4225 8 8 1.000 0.002 HPA:046010_02 hpa 1 tonsil; germinal center cells[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 1.95e-02 5 8 1 0.125 0.200 CORUM:2657 cor 1 ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex 1 P50613 137 1.95e-02 4237 8 8 1.000 0.002 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 1.98e-02 1485 8 5 0.625 0.003 REAC:74160 rea 1 Gene Expression 1 P35244,Q00059,P15927,P27694,P50613 137 2.08e-02 179 8 2 0.250 0.011 GO:0016604 CC 1 nuclear body 1 P15927,P27694 137 2.15e-02 4430 8 7 0.875 0.002 GO:0005634 CC 1 nucleus 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 2.17e-02 183 8 2 0.250 0.011 GO:0000075 BP 1 cell cycle checkpoint 1 P15927,Q13156 137 2.23e-02 1175 8 5 0.625 0.004 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 P35244,P15927,P27694,P50613,Q96FZ2 137 2.23e-02 4308 8 8 1.000 0.002 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 2.24e-02 2096 8 5 0.625 0.002 GO:0043234 CC 1 protein complex 1 P35244,P15927,P27694,P50613,Q13156 137 2.28e-02 10 8 1 0.125 0.100 GO:0008301 MF 1 DNA binding, bending 1 Q00059 137 2.28e-02 10 8 1 0.125 0.100 GO:2000001 BP 1 regulation of DNA damage checkpoint 1 P15927 137 2.32e-02 3168 8 6 0.750 0.002 GO:0044428 CC 1 nuclear part 1 P35244,P15927,Q86UA6,P27694,P50613,Q13156 137 2.33e-02 6 8 1 0.125 0.167 CORUM:5495 cor 1 TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2) 1 P50613 137 2.33e-02 6 8 1 0.125 0.167 CORUM:2638 cor 1 HES1 promoter corepressor complex 1 P50613 137 2.43e-02 2136 8 5 0.625 0.002 GO:0003676 MF 1 nucleic acid binding 1 P35244,Q00059,P15927,P27694,Q13156 137 2.51e-02 11 8 1 0.125 0.091 GO:0006390 BP 1 transcription from mitochondrial promoter 1 Q00059 137 2.51e-02 11 8 1 0.125 0.091 GO:0005675 CC 1 holo TFIIH complex 1 P50613 137 2.68e-02 4407 8 8 1.000 0.002 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 2.88e-02 4447 8 8 1.000 0.002 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 3.00e-02 679 8 3 0.375 0.004 GO:0051726 BP 1 regulation of cell cycle 1 P15927,P50613,Q13156 137 3.10e-02 8 8 1 0.125 0.125 CORUM:2739 cor 1 FA complex (Fanconi anemia complex) 1 P27694 137 3.11e-02 4491 8 8 1.000 0.002 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 3.13e-02 1263 8 5 0.625 0.004 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 P35244,P15927,Q86UA6,P27694,P50613 137 3.17e-02 2267 8 5 0.625 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P35244,Q00059,P15927,P27694,P50613 137 3.19e-02 14 8 1 0.125 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 P50613 137 3.19e-02 14 8 1 0.125 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 P50613 137 3.36e-02 707 8 3 0.375 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 P35244,P15927,P27694 137 3.38e-02 230 8 2 0.250 0.009 GO:0098687 CC 1 chromosomal region 1 P15927,P27694 137 3.41e-02 2305 8 5 0.625 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P35244,Q00059,P15927,P27694,P50613 137 3.42e-02 15 8 1 0.125 0.067 GO:0010569 BP 1 regulation of double-strand break repair via homologous recombination 1 P15927 137 3.42e-02 15 8 1 0.125 0.067 GO:0008353 MF 1 RNA polymerase II carboxy-terminal domain kinase activity 1 P50613 137 3.44e-02 2310 8 5 0.625 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 P35244,Q00059,P15927,P27694,P50613 137 3.48e-02 9 8 1 0.125 0.111 CORUM:107 cor 1 TFIIH transcription factor complex 1 P50613 137 3.48e-02 9 8 1 0.125 0.111 CORUM:1036 cor 1 TFIIH transcription factor complex 1 P50613 137 3.86e-02 10 8 1 0.125 0.100 CORUM:1029 cor 1 TFIIH transcription factor complex 1 P50613 137 3.86e-02 10 8 1 0.125 0.100 CORUM:1009 cor 1 TFIIH transcription factor complex 1 P50613 137 3.88e-02 2374 8 5 0.625 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P35244,Q00059,P15927,P27694,P50613 137 4.08e-02 22 8 1 0.125 0.045 REAC:69273 rea 1 Cyclin A/B1 associated events during G2/M transition 1 P50613 137 4.12e-02 733 8 4 0.500 0.005 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q00059,P15927,P27694,P50613 137 4.18e-02 3206 8 7 0.875 0.002 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 P35244,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 4.35e-02 4682 8 8 1.000 0.002 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 4.45e-02 783 8 3 0.375 0.004 GO:0042592 BP 1 homeostatic process 1 P35244,P15927,P27694 137 4.55e-02 20 8 1 0.125 0.050 GO:0032806 CC 1 carboxy-terminal domain protein kinase complex 1 P50613 137 4.64e-02 4990 8 7 0.875 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 P35244,Q00059,P15927,Q86UA6,P27694,P50613,Q13156 137 4.77e-02 21 8 1 0.125 0.048 GO:0033260 BP 1 nuclear DNA replication 1 Q13156 137 4.88e-02 329 8 3 0.375 0.009 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 P35244,P15927,P50613 137 4.94e-02 814 8 3 0.375 0.004 GO:0080134 BP 1 regulation of response to stress 1 P35244,P15927,P27694 137 5.00e-02 2066 8 6 0.750 0.003 TF:M05956_0 tf 1 Factor: CTIP-2; motif: RTMGTACAA; match class: 0 1 P35244,Q00059,P15927,Q86UA6,P50613,Q96FZ2 137 5.00e-02 13 8 1 0.125 0.077 CORUM:2639 cor 1 HES1 promoter-Notch enhancer complex 1 P50613 137 5.00e-02 397 8 3 0.375 0.008 MI:mmu-miR-684 mi 1 MI:mmu-miR-684 1 Q00059,P50613,Q13156 137 5.00e-02 3293 8 7 0.875 0.002 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 P35244,P15927,Q86UA6,P27694,P50613,Q96FZ2,Q13156 137 5.00e-02 27 8 1 0.125 0.037 REAC:77075 rea 1 RNA Pol II CTD phosphorylation and interaction with CE 1 P50613 137 5.00e-02 397 8 3 0.375 0.008 MI:mmu-miR-201 mi 1 MI:mmu-miR-201 1 P15927,Q86UA6,P50613 137 5.00e-02 22 8 1 0.125 0.045 GO:0006356 BP 1 regulation of transcription from RNA polymerase I promoter 1 Q00059 138 1.70e-03 1519 3 3 1.000 0.002 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 Q07955,Q96N46,P06454 138 2.04e-03 1614 3 3 1.000 0.002 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 Q07955,Q96N46,P06454 138 2.36e-03 10 3 1 0.333 0.100 TF:M04520_0 tf 1 Factor: E2F8; motif: TTTCCCGCCAAA; match class: 0 1 Q07955 138 3.06e-03 13 3 1 0.333 0.077 TF:M06098_0 tf 1 Factor: ZNF708; motif: NGNAATGGGGGA; match class: 0 1 P06454 138 3.30e-03 14 3 1 0.333 0.071 TF:M06771_0 tf 1 Factor: ZNF228; motif: NGGACTGTGTCC; match class: 0 1 P06454 138 3.53e-03 15 3 1 0.333 0.067 TF:M06834_0 tf 1 Factor: PEG3; motif: NYGKTTTTCCNA; match class: 0 1 Q96N46 138 4.38e-03 493 3 2 0.667 0.004 TF:M00737_1 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 1 Q07955,P06454 138 4.64e-03 447 3 2 0.667 0.004 MI:hsa-miR-522 mi 1 MI:hsa-miR-522 1 Q96N46,P06454 138 4.94e-03 21 3 1 0.333 0.048 TF:M07205_1 tf 1 Factor: CEBPA; motif: ATTGCAYAAYN; match class: 1 1 Q96N46 138 5.88e-03 25 3 1 0.333 0.040 TF:M07229_1 tf 1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 1 Q07955 138 6.48e-03 2013 3 3 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 Q07955,Q96N46,P06454 138 6.59e-03 28 3 1 0.333 0.036 TF:M05677_0 tf 1 Factor: ZNF816A; motif: KGGGAAAAMGGM; match class: 0 1 P06454 138 6.89e-03 546 3 2 0.667 0.004 MI:hsa-let-7b* mi 1 MI:hsa-let-7b* 1 Q96N46,P06454 138 7.05e-03 30 3 1 0.333 0.033 TF:M06732_0 tf 1 Factor: ZNF304; motif: GGGGCTTTGCTG; match class: 0 1 P06454 138 7.76e-03 33 3 1 0.333 0.030 TF:M06939_0 tf 1 Factor: ZBTB11; motif: TGGGCGCMCCCC; match class: 0 1 P06454 138 8.51e-03 608 3 2 0.667 0.003 MI:mmu-miR-466b-3-3p mi 1 MI:mmu-miR-466b-3-3p 1 Q96N46,P06454 138 8.73e-03 616 3 2 0.667 0.003 MI:mmu-miR-466d-3p mi 1 MI:mmu-miR-466d-3p 1 Q96N46,P06454 138 8.87e-03 621 3 2 0.667 0.003 MI:mmu-miR-466a-3p mi 1 MI:mmu-miR-466a-3p 1 Q96N46,P06454 138 9.28e-03 722 3 2 0.667 0.003 TF:M00050_1 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 1 1 Q07955,P06454 138 9.74e-03 2719 3 3 1.000 0.001 TF:M03806_0 tf 1 Factor: ZBTB7C; motif: GKCCCGGGCKG; match class: 0 1 Q07955,Q96N46,P06454 138 1.00e-02 751 3 2 0.667 0.003 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 Q07955,P06454 138 1.01e-02 664 3 2 0.667 0.003 MI:mmu-miR-466f-3p mi 1 MI:mmu-miR-466f-3p 1 Q96N46,P06454 138 1.16e-02 2880 3 3 1.000 0.001 TF:M00088_1 tf 1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 1 Q07955,Q96N46,P06454 138 1.27e-02 2973 3 3 1.000 0.001 TF:M00427_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 Q07955,Q96N46,P06454 138 1.37e-02 6 3 1 0.333 0.167 GO:0000395 BP 1 mRNA 5'-splice site recognition 1 Q07955 138 1.43e-02 61 3 1 0.333 0.016 TF:M05443_0 tf 1 Factor: TBX15; motif: AGGTGTGAAAN; match class: 0 1 Q96N46 138 1.59e-02 68 3 1 0.333 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q07955 138 1.78e-02 76 3 1 0.333 0.013 TF:M01208_1 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 1 1 Q96N46 138 1.82e-02 3351 3 3 1.000 0.001 TF:M04332_0 tf 1 Factor: HMBOX1; motif: MYTAGTTAMN; match class: 0 1 Q07955,Q96N46,P06454 138 1.86e-02 1032 3 2 0.667 0.002 TF:M07085_0 tf 1 Factor: E2F-6; motif: RGGCGGGARRN; match class: 0 1 Q07955,P06454 138 1.92e-02 82 3 1 0.333 0.012 TF:M04109_0 tf 1 Factor: RUNX3; motif: NRACCGCAAACCGCAN; match class: 0 1 P06454 138 2.01e-02 909 3 2 0.667 0.002 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 Q07955,P06454 138 2.01e-02 86 3 1 0.333 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 P06454 138 2.03e-02 1079 3 2 0.667 0.002 TF:M03884_0 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 0 1 Q07955,P06454 138 2.06e-02 88 3 1 0.333 0.011 TF:M04120_0 tf 1 Factor: TBR1; motif: AAGGTGTGAAA; match class: 0 1 Q96N46 138 2.08e-02 1093 3 2 0.667 0.002 TF:M07064_1 tf 1 Factor: STAT1; motif: TTCNRGGAAN; match class: 1 1 Q07955,Q96N46 138 2.15e-02 92 3 1 0.333 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 Q07955 138 2.18e-02 93 3 1 0.333 0.011 TF:M01235_0 tf 1 Factor: ipf1; motif: NVSTAATTAC; match class: 0 1 Q96N46 138 2.18e-02 93 3 1 0.333 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 P06454 138 2.20e-02 94 3 1 0.333 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 Q96N46 138 2.39e-02 102 3 1 0.333 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 P06454 138 2.50e-02 1200 3 2 0.667 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q96N46,P06454 138 2.53e-02 1025 3 2 0.667 0.002 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q07955,P06454 138 2.58e-02 1220 3 2 0.667 0.002 TF:M04292_1 tf 1 Factor: BSX; motif: NYNATTAN; match class: 1 1 Q07955,Q96N46 138 2.62e-02 1230 3 2 0.667 0.002 TF:M02377_0 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 0 1 Q96N46,P06454 138 2.63e-02 3784 3 3 1.000 0.001 TF:M04305_1 tf 1 Factor: DMBX1; motif: NNGGATTANN; match class: 1 1 Q07955,Q96N46,P06454 138 2.64e-02 113 3 1 0.333 0.009 TF:M07231_1 tf 1 Factor: TFAP2A; motif: NNNNGCCYSAGGGCA; match class: 1 1 P06454 138 2.69e-02 115 3 1 0.333 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 Q96N46 138 2.87e-02 123 3 1 0.333 0.008 TF:M00261_0 tf 1 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN; match class: 0 1 P06454 138 2.94e-02 126 3 1 0.333 0.008 TF:M03968_0 tf 1 Factor: ELF4; motif: AACCCGGAAGTR; match class: 0 1 Q96N46 138 2.94e-02 126 3 1 0.333 0.008 TF:M07417_1 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 1 1 Q96N46 138 2.96e-02 127 3 1 0.333 0.008 TF:M06283_0 tf 1 Factor: ZNF678; motif: NKGGAMGGCAGC; match class: 0 1 P06454 138 3.06e-02 131 3 1 0.333 0.008 TF:M05419_0 tf 1 Factor: ZNF499; motif: NGTTCCGGASGC; match class: 0 1 P06454 138 3.09e-02 3995 3 3 1.000 0.001 TF:M00426_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 Q07955,Q96N46,P06454 138 3.10e-02 1343 3 2 0.667 0.001 TF:M01260_0 tf 1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 0 1 Q07955,Q96N46 138 3.15e-02 135 3 1 0.333 0.007 TF:M06000_0 tf 1 Factor: ZNF233; motif: NTGTAAAARAKA; match class: 0 1 Q96N46 138 3.22e-02 138 3 1 0.333 0.007 TF:M02091_0 tf 1 Factor: E4F1; motif: RTGACGTAAC; match class: 0 1 P06454 138 3.25e-02 1375 3 2 0.667 0.001 TF:M02074_1 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 1 Q07955,Q96N46 138 3.32e-02 1392 3 2 0.667 0.001 TF:M04315_1 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 1 1 Q96N46,P06454 138 3.45e-02 148 3 1 0.333 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 P06454 138 3.54e-02 152 3 1 0.333 0.007 TF:M05756_0 tf 1 Factor: ZNF470; motif: NTGTTTAWKAWA; match class: 0 1 Q96N46 138 3.59e-02 154 3 1 0.333 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 P06454 138 3.64e-02 16 3 1 0.333 0.062 GO:0045292 BP 1 mRNA cis splicing, via spliceosome 1 Q07955 138 3.66e-02 157 3 1 0.333 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q96N46 138 3.66e-02 1241 3 2 0.667 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q07955,P06454 138 3.66e-02 1464 3 2 0.667 0.001 TF:M00327_0 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 0 1 Q07955,P06454 138 3.66e-02 4228 3 3 1.000 0.001 TF:M03549_1 tf 1 Factor: GATA-4; motif: AGATAAN; match class: 1 1 Q07955,Q96N46,P06454 138 3.75e-02 1482 3 2 0.667 0.001 TF:M04002_0 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 0 1 Q96N46,P06454 138 3.79e-02 163 3 1 0.333 0.006 TF:M05697_0 tf 1 Factor: ZNF235; motif: NCCGCWAAAYGC; match class: 0 1 P06454 138 3.80e-02 1493 3 2 0.667 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 Q07955,P06454 138 4.00e-02 172 3 1 0.333 0.006 TF:M04254_1 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 1 1 P06454 138 4.03e-02 147 3 1 0.333 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q07955 138 4.07e-02 175 3 1 0.333 0.006 TF:M07228_0 tf 1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 0 1 Q96N46 138 4.10e-02 1553 3 2 0.667 0.001 TF:M00801_1 tf 1 Factor: CREB; motif: CGTCAN; match class: 1 1 Q07955,P06454 138 4.11e-02 177 3 1 0.333 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q96N46 138 4.11e-02 177 3 1 0.333 0.006 TF:M00694_0 tf 1 Factor: E4F1; motif: SYTACGTCAC; match class: 0 1 P06454 138 4.14e-02 178 3 1 0.333 0.006 TF:M04516_1 tf 1 Factor: E2F1; motif: TTTGGCGCCAAA; match class: 1 1 P06454 138 4.19e-02 51 3 1 0.333 0.020 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q07955 138 4.21e-02 181 3 1 0.333 0.006 TF:M03966_0 tf 1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 0 1 Q96N46 138 4.21e-02 181 3 1 0.333 0.006 TF:M00420_0 tf 1 Factor: MEIS1A:HOXA9; motif: TGACAGKTTTAYGA; match class: 0 1 Q07955 138 4.27e-02 52 3 1 0.333 0.019 REAC:72187 rea 1 mRNA 3'-end processing 1 Q07955 138 4.35e-02 1602 3 2 0.667 0.001 TF:M00938_0 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 0 1 Q96N46,P06454 138 4.39e-02 189 3 1 0.333 0.005 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 P06454 138 4.41e-02 161 3 1 0.333 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q07955 138 4.41e-02 190 3 1 0.333 0.005 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 P06454 138 4.64e-02 200 3 1 0.333 0.005 TF:M01752_1 tf 1 Factor: ERG; motif: ACCGGAART; match class: 1 1 Q96N46 138 4.71e-02 203 3 1 0.333 0.005 TF:M07375_1 tf 1 Factor: BCL-6; motif: TTCCTAGAAA; match class: 1 1 Q96N46 138 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q07955,Q96N46,P06454 138 4.77e-02 21 3 1 0.333 0.048 GO:0035145 CC 1 exon-exon junction complex 1 Q07955 138 4.78e-02 206 3 1 0.333 0.005 TF:M00736_1 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 1 Q07955 138 4.87e-02 1700 3 2 0.667 0.001 TF:M07397_0 tf 1 Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 0 1 Q07955,P06454 138 4.89e-02 1703 3 2 0.667 0.001 TF:M00940_0 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 0 1 Q07955,P06454 138 4.92e-02 4666 3 3 1.000 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 Q07955,Q96N46,P06454 138 4.94e-02 213 3 1 0.333 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 Q96N46 138 4.98e-02 1719 3 2 0.667 0.001 TF:M07323_1 tf 1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 1 Q96N46,P06454 138 5.00e-02 61 3 1 0.333 0.016 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 Q07955 138 5.00e-02 22 3 1 0.333 0.045 GO:0006376 BP 1 mRNA splice site selection 1 Q07955 138 5.00e-02 29 3 1 0.333 0.034 CORUM:1183 cor 1 CDC5L complex 1 Q07955 138 5.00e-02 61 3 1 0.333 0.016 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 Q07955 139 3.64e-03 21 2 1 0.500 0.048 GO:0035145 CC 1 exon-exon junction complex 1 Q96A72 139 9.39e-03 1118 2 2 1.000 0.002 GO:0044822 MF 1 poly(A) RNA binding 1 Q9Y3X0,Q96A72 139 1.34e-02 1336 2 2 1.000 0.001 GO:0003723 MF 1 RNA binding 1 Q9Y3X0,Q96A72 139 1.52e-02 88 2 1 0.500 0.011 GO:0071013 CC 1 catalytic step 2 spliceosome 1 Q96A72 139 1.98e-02 115 2 1 0.500 0.009 GO:0000184 BP 1 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1 Q96A72 139 2.53e-02 147 2 1 0.500 0.007 GO:0005681 CC 1 spliceosomal complex 1 Q96A72 139 3.23e-02 188 2 1 0.500 0.005 GO:0000956 BP 1 nuclear-transcribed mRNA catabolic process 1 Q96A72 139 3.25e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 Q96A72 139 3.42e-02 199 2 1 0.500 0.005 GO:0006402 BP 1 mRNA catabolic process 1 Q96A72 139 3.43e-02 2136 2 2 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 Q9Y3X0,Q96A72 139 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q9Y3X0,Q96A72 139 3.73e-02 217 2 1 0.500 0.005 GO:0006401 BP 1 RNA catabolic process 1 Q96A72 139 4.26e-02 52 2 1 0.500 0.019 REAC:72187 rea 1 mRNA 3'-end processing 1 Q96A72 139 4.57e-02 259 2 1 0.500 0.004 MI:hsa-miR-191* mi 1 MI:hsa-miR-191* 1 Q9Y3X0 139 4.99e-02 128 2 1 0.500 0.008 KEGG:03040 keg 1 Spliceosome 1 Q96A72 139 5.00e-02 61 2 1 0.500 0.016 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 Q96A72 139 5.00e-02 7 2 1 0.500 0.143 TF:M06586_0 tf 1 Factor: ZNF479; motif: NGGGCMAAACGC; match class: 0 1 Q9Y3X0 139 5.00e-02 61 2 1 0.500 0.016 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 Q96A72 139 5.00e-02 7 2 1 0.500 0.143 TF:M06609_0 tf 1 Factor: ZNF307; motif: KGGGCAAAACGC; match class: 0 1 Q9Y3X0 139 5.00e-02 7 2 1 0.500 0.143 TF:M06780_0 tf 1 Factor: znf443; motif: KGGTAAAGATCT; match class: 0 1 Q9Y3X0 139 5.00e-02 7 2 1 0.500 0.143 TF:M06595_0 tf 1 Factor: ZNF799; motif: KGGTAAAGATCT; match class: 0 1 Q9Y3X0 140 3.37e-03 10 2 1 0.500 0.100 REAC:174437 rea 1 Removal of the Flap Intermediate from the C-strand 1 P35244 140 3.70e-03 11 2 1 0.500 0.091 REAC:174414 rea 1 Processive synthesis on the C-strand of the telomere 1 P35244 140 4.71e-03 14 2 1 0.500 0.071 REAC:5358565 rea 1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1 P35244 140 4.71e-03 14 2 1 0.500 0.071 REAC:69166 rea 1 Removal of the Flap Intermediate 1 P35244 140 4.71e-03 14 2 1 0.500 0.071 REAC:5358606 rea 1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1 P35244 140 5.05e-03 15 2 1 0.500 0.067 REAC:110312 rea 1 Translesion synthesis by REV1 1 P35244 140 5.05e-03 15 2 1 0.500 0.067 REAC:5358508 rea 1 Mismatch Repair 1 P35244 140 5.05e-03 15 2 1 0.500 0.067 REAC:69183 rea 1 Processive synthesis on the lagging strand 1 P35244 140 5.30e-03 786 2 2 1.000 0.003 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 O60784,P35244 140 5.38e-03 16 2 1 0.500 0.062 REAC:5655862 rea 1 Translesion synthesis by POLK 1 P35244 140 5.38e-03 16 2 1 0.500 0.062 REAC:5656121 rea 1 Translesion synthesis by POLI 1 P35244 140 6.06e-03 18 2 1 0.500 0.056 REAC:110320 rea 1 Translesion Synthesis by POLH 1 P35244 140 6.44e-03 867 2 2 1.000 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 O60784,P35244 140 6.73e-03 20 2 1 0.500 0.050 REAC:69186 rea 1 Lagging Strand Synthesis 1 P35244 140 7.06e-03 21 2 1 0.500 0.048 REAC:5651801 rea 1 PCNA-Dependent Long Patch Base Excision Repair 1 P35244 140 8.07e-03 24 2 1 0.500 0.042 REAC:5696397 rea 1 Gap-filling DNA repair synthesis and ligation in GG-NER 1 P35244 140 8.07e-03 24 2 1 0.500 0.042 REAC:110373 rea 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 P35244 140 8.07e-03 24 2 1 0.500 0.042 REAC:174417 rea 1 Telomere C-strand (Lagging Strand) Synthesis 1 P35244 140 8.41e-03 25 2 1 0.500 0.040 REAC:3371511 rea 1 HSF1 activation 1 P35244 140 9.41e-03 28 2 1 0.500 0.036 REAC:110314 rea 1 Recognition of DNA damage by PCNA-containing replication complex 1 P35244 140 9.54e-03 1055 2 2 1.000 0.002 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 O60784,P35244 140 9.75e-03 29 2 1 0.500 0.034 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 P35244 140 9.75e-03 29 2 1 0.500 0.034 REAC:6783310 rea 1 Fanconi Anemia Pathway 1 P35244 140 1.01e-02 30 2 1 0.500 0.033 REAC:180786 rea 1 Extension of Telomeres 1 P35244 140 1.04e-02 31 2 1 0.500 0.032 REAC:68962 rea 1 Activation of the pre-replicative complex 1 P35244 140 1.08e-02 32 2 1 0.500 0.031 REAC:69190 rea 1 DNA strand elongation 1 P35244 140 1.18e-02 35 2 1 0.500 0.029 REAC:73884 rea 1 Base Excision Repair 1 P35244 140 1.18e-02 35 2 1 0.500 0.029 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 P35244 140 1.21e-02 36 2 1 0.500 0.028 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 P35244 140 1.21e-02 36 2 1 0.500 0.028 REAC:176187 rea 1 Activation of ATR in response to replication stress 1 P35244 140 1.21e-02 36 2 1 0.500 0.028 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 P35244 140 1.28e-02 38 2 1 0.500 0.026 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 P35244 140 1.34e-02 40 2 1 0.500 0.025 REAC:5696400 rea 1 Dual Incision in GG-NER 1 P35244 140 1.38e-02 41 2 1 0.500 0.024 REAC:912446 rea 1 Meiotic recombination 1 P35244 140 1.38e-02 41 2 1 0.500 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 P35244 140 1.41e-02 42 2 1 0.500 0.024 REAC:5696395 rea 1 Formation of Incision Complex in GG-NER 1 P35244 140 1.48e-02 44 2 1 0.500 0.023 REAC:73893 rea 1 DNA Damage Bypass 1 P35244 140 1.50e-02 3 2 1 0.500 0.333 CORUM:5229 cor 1 RPA complex 1 P35244 140 1.71e-02 51 2 1 0.500 0.020 REAC:157579 rea 1 Telomere Maintenance 1 P35244 140 1.78e-02 1440 2 2 1.000 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 O60784,P35244 140 1.83e-02 1462 2 2 1.000 0.001 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 O60784,P35244 140 1.90e-02 1488 2 2 1.000 0.001 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 O60784,P35244 140 1.95e-02 1508 2 2 1.000 0.001 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 O60784,P35244 140 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 O60784,P35244 140 2.05e-02 61 2 1 0.500 0.016 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 P35244 140 2.11e-02 63 2 1 0.500 0.016 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 P35244 140 2.15e-02 64 2 1 0.500 0.016 REAC:6782135 rea 1 Dual incision in TC-NER 1 P35244 140 2.28e-02 68 2 1 0.500 0.015 REAC:1500620 rea 1 Meiosis 1 P35244 140 2.41e-02 72 2 1 0.500 0.014 REAC:69473 rea 1 G2/M DNA damage checkpoint 1 P35244 140 2.48e-02 74 2 1 0.500 0.014 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 P35244 140 2.51e-02 75 2 1 0.500 0.013 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 P35244 140 2.54e-02 1722 2 2 1.000 0.001 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 O60784,P35244 140 2.58e-02 77 2 1 0.500 0.013 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 P35244 140 2.61e-02 78 2 1 0.500 0.013 REAC:73886 rea 1 Chromosome Maintenance 1 P35244 140 2.78e-02 83 2 1 0.500 0.012 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 P35244 140 2.78e-02 83 2 1 0.500 0.012 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 P35244 140 2.78e-02 83 2 1 0.500 0.012 REAC:68874 rea 1 M/G1 Transition 1 P35244 140 2.88e-02 86 2 1 0.500 0.012 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 P35244 140 3.00e-02 6 2 1 0.500 0.167 CORUM:2738 cor 1 BLM complex II 1 P35244 140 3.00e-02 6 2 1 0.500 0.167 CORUM:2222 cor 1 BLM complex II 1 P35244 140 3.05e-02 91 2 1 0.500 0.011 REAC:3371556 rea 1 Cellular response to heat stress 1 P35244 140 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 O60784,P35244 140 3.20e-02 23 2 1 0.500 0.043 KEGG:03430 keg 1 Mismatch repair 1 P35244 140 3.23e-02 1941 2 2 1.000 0.001 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 O60784,P35244 140 3.26e-02 15 2 1 0.500 0.067 GO:0005662 CC 1 DNA replication factor A complex 1 P35244 140 3.31e-02 99 2 1 0.500 0.010 REAC:69239 rea 1 Synthesis of DNA 1 P35244 140 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 O60784,P35244 140 3.48e-02 104 2 1 0.500 0.010 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 P35244 140 3.54e-02 106 2 1 0.500 0.009 REAC:69306 rea 1 DNA Replication 1 P35244 140 3.64e-02 109 2 1 0.500 0.009 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P35244 140 3.68e-02 110 2 1 0.500 0.009 REAC:5693538 rea 1 Homology Directed Repair 1 P35244 140 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 O60784,P35244 140 3.84e-02 115 2 1 0.500 0.009 REAC:69206 rea 1 G1/S Transition 1 P35244 140 3.91e-02 18 2 1 0.500 0.056 GO:0042276 BP 1 error-prone translesion synthesis 1 P35244 140 3.91e-02 18 2 1 0.500 0.056 GO:0070987 BP 1 error-free translesion synthesis 1 P35244 140 3.95e-02 2146 2 2 1.000 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 O60784,P35244 140 4.00e-02 8 2 1 0.500 0.125 CORUM:248 cor 1 BRAFT complex 1 P35244 140 4.21e-02 126 2 1 0.500 0.008 REAC:69242 rea 1 S Phase 1 P35244 140 4.57e-02 21 2 1 0.500 0.048 GO:0006293 BP 1 nucleotide-excision repair, preincision complex stabilization 1 P35244 140 4.57e-02 21 2 1 0.500 0.048 GO:0006295 BP 1 nucleotide-excision repair, DNA incision, 3'-to lesion 1 P35244 140 4.57e-02 137 2 1 0.500 0.007 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 P35244 140 4.60e-02 138 2 1 0.500 0.007 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P35244 140 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 O60784,P35244 140 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 O60784,P35244 140 4.77e-02 143 2 1 0.500 0.007 REAC:69481 rea 1 G2/M Checkpoints 1 P35244 140 4.85e-02 265 2 1 0.500 0.004 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 P35244 140 5.00e-02 36 2 1 0.500 0.028 KEGG:03030 keg 1 DNA replication 1 P35244 140 5.00e-02 10 2 1 0.500 0.100 CORUM:244 cor 1 BRAFT complex 1 P35244 140 5.00e-02 150 2 1 0.500 0.007 REAC:5633007 rea 1 Regulation of TP53 Activity 1 P35244 140 5.00e-02 23 2 1 0.500 0.043 GO:0006297 BP 1 nucleotide-excision repair, DNA gap filling 1 P35244 140 5.00e-02 217 2 2 1.000 0.009 TF:M05956_1 tf 1 Factor: CTIP-2; motif: RTMGTACAA; match class: 1 1 O60784,P35244 141 2.67e-03 17 2 1 0.500 0.059 TF:M07126_1 tf 1 Factor: Smad2:Smad3:Smad4; motif: NTGTCTGNCACCT; match class: 1 1 Q9UBK7 141 4.71e-03 30 2 1 0.500 0.033 TF:M06732_0 tf 1 Factor: ZNF304; motif: GGGGCTTTGCTG; match class: 0 1 Q9UBK7 141 1.06e-02 1309 2 2 1.000 0.002 TF:M04633_1 tf 1 Factor: TCF-4; motif: NCTTTGAWNN; match class: 1 1 Q96HJ3,Q9UBK7 141 1.36e-02 87 2 1 0.500 0.011 TF:M06603_0 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 0 1 Q96HJ3 141 1.36e-02 87 2 1 0.500 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 Q96HJ3 141 1.43e-02 1524 2 2 1.000 0.001 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q96HJ3,Q9UBK7 141 1.68e-02 1648 2 2 1.000 0.001 TF:M00252_1 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 1 1 Q96HJ3,Q9UBK7 141 1.72e-02 110 2 1 0.500 0.009 TF:M04097_1 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 1 1 Q96HJ3 141 1.75e-02 112 2 1 0.500 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 Q9UBK7 141 2.62e-02 168 2 1 0.500 0.006 TF:M06322_0 tf 1 Factor: ZNF181; motif: NCGGAAAGACGC; match class: 0 1 Q96HJ3 141 2.72e-02 2098 2 2 1.000 0.001 TF:M07296_1 tf 1 Factor: MAF; motif: GCTGAGTCAN; match class: 1 1 Q96HJ3,Q9UBK7 141 2.72e-02 2099 2 2 1.000 0.001 TF:M07376_0 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 0 1 Q96HJ3,Q9UBK7 141 2.72e-02 158 2 1 0.500 0.006 GO:0003924 MF 1 GTPase activity 1 Q9UBK7 141 2.81e-02 180 2 1 0.500 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 Q96HJ3 141 2.83e-02 2140 2 2 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 Q96HJ3,Q9UBK7 141 2.99e-02 192 2 1 0.500 0.005 TF:M01119_0 tf 1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 0 1 Q9UBK7 141 3.03e-02 194 2 1 0.500 0.005 TF:M06135_0 tf 1 Factor: ZNF28; motif: GCKAAAGGAWA; match class: 0 1 Q9UBK7 141 3.14e-02 2256 2 2 1.000 0.001 TF:M04287_1 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 1 Q96HJ3,Q9UBK7 141 3.43e-02 220 2 1 0.500 0.005 TF:M00777_1 tf 1 Factor: STAT; motif: NNNNNTTCTKGGA; match class: 1 1 Q96HJ3 141 3.47e-02 223 2 1 0.500 0.004 TF:M06677_0 tf 1 Factor: ZNF285; motif: NGTTCMKAAAGM; match class: 0 1 Q9UBK7 141 3.51e-02 2384 2 2 1.000 0.001 TF:M00802_0 tf 1 Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 0 1 Q96HJ3,Q9UBK7 141 3.63e-02 233 2 1 0.500 0.004 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 Q96HJ3 141 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q96HJ3 141 3.97e-02 255 2 1 0.500 0.004 TF:M07337_0 tf 1 Factor: SMAR1; motif: YAAMSTGCTGAK; match class: 0 1 Q96HJ3 141 4.04e-02 260 2 1 0.500 0.004 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 Q96HJ3 141 4.12e-02 265 2 1 0.500 0.004 TF:M01260_1 tf 1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 1 Q96HJ3 141 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 Q96HJ3 141 4.23e-02 2617 2 2 1.000 0.001 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 Q96HJ3,Q9UBK7 141 4.47e-02 2690 2 2 1.000 0.001 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 Q96HJ3,Q9UBK7 141 4.52e-02 291 2 1 0.500 0.003 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 Q96HJ3 141 4.53e-02 2710 2 2 1.000 0.001 TF:M03794_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q96HJ3,Q9UBK7 141 4.53e-02 2710 2 2 1.000 0.001 TF:M02019_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q96HJ3,Q9UBK7 141 5.00e-02 473 2 2 1.000 0.004 MI:hsa-miR-532-5p mi 1 MI:hsa-miR-532-5p 1 Q96HJ3,Q9UBK7 142 1.44e-05 1813 7 7 1.000 0.004 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 2.61e-05 1974 7 7 1.000 0.004 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 4.44e-05 2130 7 7 1.000 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 5.85e-05 2215 7 7 1.000 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 7.03e-05 2274 7 7 1.000 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 7.85e-05 2310 7 7 1.000 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.43e-04 11 7 2 0.286 0.182 GO:0001533 CC 1 cornified envelope 1 P07476,Q92817 142 1.84e-04 101 7 3 0.429 0.030 GO:0008544 BP 1 epidermis development 1 P07476,Q92817,Q9NZT1 142 2.36e-04 14 7 2 0.286 0.143 GO:0018149 BP 1 peptide cross-linking 1 P07476,Q92817 142 3.06e-04 1659 7 6 0.857 0.004 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 142 4.65e-04 1782 7 6 0.857 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P19971,O60437,Q14134,P07476,P06702,Q9NZT1 142 8.53e-04 3247 7 7 1.000 0.002 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.03e-03 3334 7 7 1.000 0.002 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.05e-03 3344 7 7 1.000 0.002 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.07e-03 3355 7 7 1.000 0.002 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.09e-03 3361 7 7 1.000 0.002 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.10e-03 3368 7 7 1.000 0.002 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.11e-03 3370 7 7 1.000 0.002 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.13e-03 3379 7 7 1.000 0.002 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.14e-03 3386 7 7 1.000 0.002 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.14e-03 3386 7 7 1.000 0.002 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.14e-03 3386 7 7 1.000 0.002 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.15e-03 3390 7 7 1.000 0.002 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.19e-03 3403 7 7 1.000 0.002 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.19e-03 3405 7 7 1.000 0.002 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.19e-03 3407 7 7 1.000 0.002 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.19e-03 3407 7 7 1.000 0.002 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.21e-03 3412 7 7 1.000 0.002 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.21e-03 3413 7 7 1.000 0.002 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.21e-03 3415 7 7 1.000 0.002 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.22e-03 3416 7 7 1.000 0.002 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.22e-03 3416 7 7 1.000 0.002 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.22e-03 3416 7 7 1.000 0.002 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.22e-03 3418 7 7 1.000 0.002 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3420 7 7 1.000 0.002 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3421 7 7 1.000 0.002 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3422 7 7 1.000 0.002 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3422 7 7 1.000 0.002 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3423 7 7 1.000 0.002 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.23e-03 3423 7 7 1.000 0.002 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.24e-03 3424 7 7 1.000 0.002 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.24e-03 3426 7 7 1.000 0.002 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.24e-03 3426 7 7 1.000 0.002 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.25e-03 3428 7 7 1.000 0.002 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.25e-03 3429 7 7 1.000 0.002 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.25e-03 3429 7 7 1.000 0.002 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.25e-03 3429 7 7 1.000 0.002 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.25e-03 3430 7 7 1.000 0.002 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3431 7 7 1.000 0.002 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3432 7 7 1.000 0.002 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3433 7 7 1.000 0.002 HPA:018020_10 hpa 1 hippocampus; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3433 7 7 1.000 0.002 HPA:032010_10 hpa 1 salivary gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3433 7 7 1.000 0.002 HPA:007030_10 hpa 1 cerebral cortex; neuronal cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:038010_10 hpa 1 smooth muscle; smooth muscle cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:030010_10 hpa 1 prostate; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:044010_10 hpa 1 testis; Leydig cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:011020_10 hpa 1 endometrium 1; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:022010_10 hpa 1 lung; macrophages[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:007020_10 hpa 1 cerebral cortex; glial cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:037010_10 hpa 1 small intestine; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.26e-03 3434 7 7 1.000 0.002 HPA:021020_10 hpa 1 liver; hepatocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:044020_10 hpa 1 testis; cells in seminiferous ducts[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:019020_10 hpa 1 kidney; cells in tubules[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:015010_10 hpa 1 fallopian tube; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:041010_10 hpa 1 spleen; cells in red pulp[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:017010_10 hpa 1 heart muscle; myocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:029020_10 hpa 1 placenta; trophoblastic cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:045010_10 hpa 1 thyroid gland; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:022020_10 hpa 1 lung; pneumocytes[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:027010_10 hpa 1 pancreas; exocrine glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.27e-03 3435 7 7 1.000 0.002 HPA:010010_10 hpa 1 duodenum; glandular cells[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.57e-03 2197 7 6 0.857 0.003 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q9NZT1 142 1.90e-03 2271 7 6 0.857 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 142 2.22e-03 42 7 2 0.286 0.048 GO:0030216 BP 1 keratinocyte differentiation 1 P07476,Q92817 142 2.31e-03 1396 7 5 0.714 0.004 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702,Q9NZT1 142 3.46e-03 271 7 3 0.429 0.011 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 O60437,Q14134,Q92817 142 3.61e-03 275 7 3 0.429 0.011 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 O60437,Q14134,Q92817 142 3.63e-03 1535 7 5 0.714 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P19971,Q14134,P07476,P06702,Q9NZT1 142 3.69e-03 277 7 3 0.429 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 O60437,Q14134,Q92817 142 3.89e-03 282 7 3 0.429 0.011 GO:0045296 MF 1 cadherin binding 1 O60437,Q14134,Q92817 142 3.92e-03 2574 7 6 0.857 0.002 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 4.24e-03 58 7 2 0.286 0.034 GO:0009913 BP 1 epidermal cell differentiation 1 P07476,Q92817 142 4.39e-03 294 7 3 0.429 0.010 GO:0005913 CC 1 cell-cell adherens junction 1 O60437,Q14134,Q92817 142 5.01e-03 1 7 1 0.143 1.000 GO:0018262 BP 1 isopeptide cross-linking 1 P07476 142 5.01e-03 1 7 1 0.143 1.000 GO:0018153 BP 1 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine 1 P07476 142 7.66e-03 78 7 2 0.286 0.026 GO:0043588 BP 1 skin development 1 P07476,Q92817 142 7.98e-03 2914 7 6 0.857 0.002 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,Q92817,Q9NZT1 142 8.06e-03 1818 7 5 0.714 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702,Q92817 142 8.53e-03 369 7 3 0.429 0.008 GO:0050839 MF 1 cell adhesion molecule binding 1 O60437,Q14134,Q92817 142 8.88e-03 84 7 2 0.286 0.024 GO:0045111 CC 1 intermediate filament cytoskeleton 1 Q14134,Q92817 142 9.65e-03 7 7 1 0.143 0.143 KEGG:04744 keg 1 Phototransduction 1 Q9NZT1 142 1.00e-02 2 7 1 0.143 0.500 GO:0070488 BP 1 neutrophil aggregation 1 P06702 142 1.00e-02 2 7 1 0.143 0.500 GO:0035606 BP 1 peptidyl-cysteine S-trans-nitrosylation 1 P06702 142 1.03e-02 3045 7 6 0.857 0.002 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,Q92817,Q9NZT1 142 1.19e-02 505 7 3 0.429 0.006 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q14134,P07476,P06702 142 1.19e-02 414 7 3 0.429 0.007 GO:0005198 MF 1 structural molecule activity 1 O60437,P07476,Q92817 142 1.24e-02 420 7 3 0.429 0.007 GO:0005911 CC 1 cell-cell junction 1 O60437,Q14134,Q92817 142 1.38e-02 3208 7 6 0.857 0.002 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P19971,Q14134,P07476,P06702,Q92817,Q9NZT1 142 1.41e-02 106 7 2 0.286 0.019 GO:0030674 MF 1 protein binding, bridging 1 P07476,Q92817 142 1.48e-02 2072 7 5 0.714 0.002 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 O60437,Q14134,P07476,Q92817,Q9NZT1 142 1.50e-02 3 7 1 0.143 0.333 GO:0050543 MF 1 icosatetraenoic acid binding 1 P06702 142 1.50e-02 3 7 1 0.143 0.333 GO:0050544 MF 1 arachidonic acid binding 1 P06702 142 1.50e-02 3 7 1 0.143 0.333 GO:0018199 BP 1 peptidyl-glutamine modification 1 P07476 142 1.50e-02 3 7 1 0.143 0.333 GO:0050542 MF 1 icosanoid binding 1 P06702 142 1.50e-02 3 7 1 0.143 0.333 GO:0002523 BP 1 leukocyte migration involved in inflammatory response 1 P06702 142 1.50e-02 3 7 1 0.143 0.333 GO:1901567 MF 1 fatty acid derivative binding 1 P06702 142 1.63e-02 564 7 3 0.429 0.005 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q14134,P07476,P06702 142 1.69e-02 3326 7 6 0.857 0.002 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P19971,O60437,P07476,P06702,Q92817,Q9NZT1 142 1.70e-02 305 7 3 0.429 0.010 MI:mmu-miR-718 mi 1 MI:mmu-miR-718 1 P19971,Q14134,Q9NZT1 142 1.74e-02 3344 7 6 0.857 0.002 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P19971,O60437,Q14134,P07476,P06702,Q92817 142 1.80e-02 120 7 2 0.286 0.017 GO:0060090 MF 1 binding, bridging 1 P07476,Q92817 142 1.95e-02 2200 7 5 0.714 0.002 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P19971,Q14134,P07476,P06702,Q92817 142 2.00e-02 4 7 1 0.143 0.250 GO:0035662 MF 1 Toll-like receptor 4 binding 1 P06702 142 2.27e-02 634 7 3 0.429 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q14134,P06702,Q9NZT1 142 2.44e-02 650 7 3 0.429 0.005 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q14134,P06702,Q92817 142 2.51e-02 3 7 1 0.143 0.333 HP:0100613 hp 1 Death in early adulthood 1 P19971 142 2.51e-02 3 7 1 0.143 0.333 HP:0002254 hp 1 Intermittent diarrhea 1 P19971 142 2.63e-02 1204 7 4 0.571 0.003 GO:0005856 CC 1 cytoskeleton 1 O60437,Q14134,P06702,Q92817 142 2.94e-02 5381 7 7 1.000 0.001 HPA:004010 hpa 1 breast; adipocytes 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 3.00e-02 6 7 1 0.143 0.167 GO:0004645 MF 1 phosphorylase activity 1 P19971 142 3.00e-02 6 7 1 0.143 0.167 GO:0050832 BP 1 defense response to fungus 1 P06702 142 3.05e-02 2194 7 5 0.714 0.002 GO:0070062 CC 1 extracellular exosome 1 O60437,P07476,P06702,Q92817,Q9NZT1 142 3.11e-02 2435 7 5 0.714 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P19971,O60437,Q14134,P07476,Q92817 142 3.12e-02 2205 7 5 0.714 0.002 GO:1903561 CC 1 extracellular vesicle 1 O60437,P07476,P06702,Q92817,Q9NZT1 142 3.12e-02 2205 7 5 0.714 0.002 GO:0043230 CC 1 extracellular organelle 1 O60437,P07476,P06702,Q92817,Q9NZT1 142 3.17e-02 582 7 3 0.429 0.005 GO:0005912 CC 1 adherens junction 1 O60437,Q14134,Q92817 142 3.31e-02 591 7 3 0.429 0.005 GO:0070161 CC 1 anchoring junction 1 O60437,Q14134,Q92817 142 3.35e-02 5483 7 7 1.000 0.001 HPA:046030_02 hpa 1 tonsil; squamous epithelial cells[Uncertain,Medium] 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 3.41e-02 733 7 3 0.429 0.004 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q14134,P06702,Q92817 142 3.50e-02 7 7 1 0.143 0.143 GO:0036041 MF 1 long-chain fatty acid binding 1 P06702 142 3.63e-02 1513 7 4 0.571 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 O60437,Q14134,P07476,P06702 142 3.85e-02 900 7 4 0.571 0.004 TF:M03565_1 tf 1 Factor: slug; motif: KCACCTGN; match class: 1 1 P19971,P07476,P06702,Q92817 142 4.00e-02 1728 7 5 0.714 0.003 TF:M07351_0 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 0 1 P19971,P07476,P06702,Q92817,Q9NZT1 142 4.00e-02 8 7 1 0.143 0.125 GO:0035325 MF 1 Toll-like receptor binding 1 P06702 142 4.00e-02 8 7 1 0.143 0.125 GO:0050786 MF 1 RAGE receptor binding 1 P06702 142 4.17e-02 5 7 1 0.143 0.200 HP:0003434 hp 1 Sensory ataxic neuropathy 1 P19971 142 4.25e-02 186 7 2 0.286 0.011 GO:0005509 MF 1 calcium ion binding 1 P06702,Q9NZT1 142 4.44e-02 2935 7 6 0.857 0.002 TF:M01889_1 tf 1 Factor: Smad4; motif: TGTCTGN; match class: 1 1 P19971,O60437,Q14134,P07476,P06702,Q9NZT1 142 4.50e-02 9 7 1 0.143 0.111 GO:0010224 BP 1 response to UV-B 1 P07476 142 4.50e-02 9 7 1 0.143 0.111 GO:0018119 BP 1 peptidyl-cysteine S-nitrosylation 1 P06702 142 4.50e-02 9 7 1 0.143 0.111 GO:0009620 BP 1 response to fungus 1 P06702 142 4.50e-02 9 7 1 0.143 0.111 GO:0017014 BP 1 protein nitrosylation 1 P06702 142 4.68e-02 432 7 3 0.429 0.007 MI:hsa-miR-663 mi 1 MI:hsa-miR-663 1 P19971,P06702,Q9NZT1 142 4.74e-02 35 7 1 0.143 0.029 KEGG:00983 keg 1 Drug metabolism - other enzymes 1 P19971 142 4.88e-02 36 7 1 0.143 0.028 KEGG:05219 keg 1 Bladder cancer 1 P19971 142 4.97e-02 441 7 3 0.429 0.007 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 O60437,P06702,Q92817 142 5.00e-02 6 7 1 0.143 0.167 HP:0002578 hp 1 Gastroparesis 1 P19971 142 5.00e-02 87 7 2 0.286 0.023 TF:M01045_1 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 1 1 P06702,Q9NZT1 142 5.00e-02 10 7 1 0.143 0.100 GO:0032119 BP 1 sequestering of zinc ion 1 P06702 142 5.00e-02 442 7 3 0.429 0.007 MI:hsa-miR-770-5p mi 1 MI:hsa-miR-770-5p 1 O60437,P06702,Q9NZT1 142 5.00e-02 5806 7 7 1.000 0.001 HPA:040010 hpa 1 soft tissue 2; adipocytes 1 P19971,O60437,Q14134,P07476,P06702,Q92817,Q9NZT1 142 5.00e-02 10 7 1 0.143 0.100 REAC:73614 rea 1 Pyrimidine salvage reactions 1 P19971 142 5.00e-02 11 7 1 0.143 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 P19971 143 5.12e-04 1 2 1 0.500 1.000 GO:1901523 BP 1 icosanoid catabolic process 1 O95870 143 5.12e-04 1 2 1 0.500 1.000 GO:1901569 BP 1 fatty acid derivative catabolic process 1 O95870 143 5.12e-04 1 2 1 0.500 1.000 GO:1905344 BP 1 prostaglandin catabolic process 1 O95870 143 1.02e-03 2 2 1 0.500 0.500 GO:0052651 BP 1 monoacylglycerol catabolic process 1 O95870 143 1.02e-03 2 2 1 0.500 0.500 GO:0046462 BP 1 monoacylglycerol metabolic process 1 O95870 143 1.54e-03 3 2 1 0.500 0.333 GO:0005232 MF 1 serotonin-activated cation-selective channel activity 1 Q8WXA8 143 3.86e-03 12 2 1 0.500 0.083 REAC:975298 rea 1 Ligand-gated ion channel transport 1 Q8WXA8 143 4.10e-03 8 2 1 0.500 0.125 GO:0047372 MF 1 acylglycerol lipase activity 1 O95870 143 5.63e-03 11 2 1 0.500 0.091 GO:0022848 MF 1 acetylcholine-gated cation-selective channel activity 1 Q8WXA8 143 5.63e-03 11 2 1 0.500 0.091 GO:0015464 MF 1 acetylcholine receptor activity 1 Q8WXA8 143 5.63e-03 11 2 1 0.500 0.091 GO:0099589 MF 1 serotonin receptor activity 1 Q8WXA8 143 5.63e-03 11 2 1 0.500 0.091 GO:0004993 MF 1 G-protein coupled serotonin receptor activity 1 Q8WXA8 143 6.15e-03 12 2 1 0.500 0.083 GO:0005892 CC 1 acetylcholine-gated channel complex 1 Q8WXA8 143 6.15e-03 12 2 1 0.500 0.083 GO:0042166 MF 1 acetylcholine binding 1 Q8WXA8 143 6.66e-03 13 2 1 0.500 0.077 GO:0042165 MF 1 neurotransmitter binding 1 Q8WXA8 143 6.66e-03 13 2 1 0.500 0.077 GO:0004622 MF 1 lysophospholipase activity 1 O95870 143 7.17e-03 14 2 1 0.500 0.071 GO:0005231 MF 1 excitatory extracellular ligand-gated ion channel activity 1 Q8WXA8 143 8.19e-03 16 2 1 0.500 0.062 GO:0007271 BP 1 synaptic transmission, cholinergic 1 Q8WXA8 143 8.19e-03 16 2 1 0.500 0.062 GO:0006693 BP 1 prostaglandin metabolic process 1 O95870 143 8.19e-03 16 2 1 0.500 0.062 GO:0006692 BP 1 prostanoid metabolic process 1 O95870 143 8.32e-03 544 2 2 1.000 0.004 TF:M01874_0 tf 1 Factor: EKLF; motif: CCACACCCNS; match class: 0 1 Q8WXA8,O95870 143 9.22e-03 18 2 1 0.500 0.056 GO:0008227 MF 1 G-protein coupled amine receptor activity 1 Q8WXA8 143 1.13e-02 22 2 1 0.500 0.045 GO:0046464 BP 1 acylglycerol catabolic process 1 O95870 143 1.13e-02 22 2 1 0.500 0.045 GO:0046461 BP 1 neutral lipid catabolic process 1 O95870 143 1.54e-02 30 2 1 0.500 0.033 GO:0005230 MF 1 extracellular ligand-gated ion channel activity 1 Q8WXA8 143 1.74e-02 34 2 1 0.500 0.029 GO:0046503 BP 1 glycerolipid catabolic process 1 O95870 143 1.94e-02 38 2 1 0.500 0.026 GO:0070405 MF 1 ammonium ion binding 1 Q8WXA8 143 1.96e-02 834 2 2 1.000 0.002 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 Q8WXA8,O95870 143 2.11e-02 867 2 2 1.000 0.002 TF:M01834_0 tf 1 Factor: Hoxd9; motif: AVNCATWAAA; match class: 0 1 Q8WXA8,O95870 143 2.35e-02 46 2 1 0.500 0.022 GO:0030594 MF 1 neurotransmitter receptor activity 1 Q8WXA8 143 2.56e-02 50 2 1 0.500 0.020 GO:1901568 BP 1 fatty acid derivative metabolic process 1 O95870 143 2.56e-02 50 2 1 0.500 0.020 GO:0006690 BP 1 icosanoid metabolic process 1 O95870 143 2.58e-02 36 2 1 0.500 0.028 TF:M05565_0 tf 1 Factor: ZNF772; motif: KGGTATGCCAKA; match class: 0 1 O95870 143 2.72e-02 45 2 1 0.500 0.022 KEGG:04742 keg 1 Taste transduction 1 Q8WXA8 143 2.96e-02 58 2 1 0.500 0.017 GO:0004620 MF 1 phospholipase activity 1 O95870 143 3.15e-02 44 2 1 0.500 0.023 TF:M06436_0 tf 1 Factor: ZNF836; motif: NTGGGCAAACKT; match class: 0 1 Q8WXA8 143 3.32e-02 65 2 1 0.500 0.015 GO:0052689 MF 1 carboxylic ester hydrolase activity 1 O95870 143 3.37e-02 66 2 1 0.500 0.015 GO:0033559 BP 1 unsaturated fatty acid metabolic process 1 O95870 143 3.51e-02 49 2 1 0.500 0.020 TF:M06325_0 tf 1 Factor: ZNF585A; motif: ATGTNTAAAAWC; match class: 0 1 Q8WXA8 143 3.58e-02 70 2 1 0.500 0.014 GO:0009062 BP 1 fatty acid catabolic process 1 O95870 143 3.58e-02 70 2 1 0.500 0.014 GO:0006638 BP 1 neutral lipid metabolic process 1 O95870 143 3.58e-02 70 2 1 0.500 0.014 GO:0006639 BP 1 acylglycerol metabolic process 1 O95870 143 3.68e-02 72 2 1 0.500 0.014 GO:0016298 MF 1 lipase activity 1 O95870 143 4.01e-02 56 2 1 0.500 0.018 TF:M06138_0 tf 1 Factor: ZNF23; motif: NGGTACGGSCTW; match class: 0 1 O95870 143 4.14e-02 81 2 1 0.500 0.012 GO:0022834 MF 1 ligand-gated channel activity 1 Q8WXA8 143 4.14e-02 81 2 1 0.500 0.012 GO:0015276 MF 1 ligand-gated ion channel activity 1 Q8WXA8 143 4.19e-02 82 2 1 0.500 0.012 GO:0072329 BP 1 monocarboxylic acid catabolic process 1 O95870 143 4.22e-02 59 2 1 0.500 0.017 TF:M05523_0 tf 1 Factor: ZBTB46; motif: NGGGGGATAGN; match class: 0 1 Q8WXA8 143 4.24e-02 1227 2 2 1.000 0.002 TF:M07314_0 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 0 1 Q8WXA8,O95870 143 5.00e-02 157 2 1 0.500 0.006 REAC:983712 rea 1 Ion channel transport 1 Q8WXA8 143 5.00e-02 1333 2 2 1.000 0.002 TF:M07372_0 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 0 1 Q8WXA8,O95870 143 5.00e-02 83 2 1 0.500 0.012 KEGG:04726 keg 1 Serotonergic synapse 1 Q8WXA8 143 5.00e-02 98 2 1 0.500 0.010 GO:0098802 CC 1 plasma membrane receptor complex 1 Q8WXA8 144 1.79e-06 59 4 3 0.750 0.051 GO:0017015 BP 1 regulation of transforming growth factor beta receptor signaling pathway 1 Q9HAU4,Q8NFG4,O15165 144 1.79e-06 59 4 3 0.750 0.051 GO:1903844 BP 1 regulation of cellular response to transforming growth factor beta stimulus 1 Q9HAU4,Q8NFG4,O15165 144 1.12e-05 108 4 3 0.750 0.028 GO:0007179 BP 1 transforming growth factor beta receptor signaling pathway 1 Q9HAU4,Q8NFG4,O15165 144 1.22e-05 111 4 3 0.750 0.027 GO:0090092 BP 1 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q9HAU4,Q8NFG4,O15165 144 1.36e-05 115 4 3 0.750 0.026 GO:0090287 BP 1 regulation of cellular response to growth factor stimulus 1 Q9HAU4,Q8NFG4,O15165 144 1.87e-05 128 4 3 0.750 0.023 GO:0071560 BP 1 cellular response to transforming growth factor beta stimulus 1 Q9HAU4,Q8NFG4,O15165 144 1.92e-05 129 4 3 0.750 0.023 GO:0071559 BP 1 response to transforming growth factor beta 1 Q9HAU4,Q8NFG4,O15165 144 3.26e-05 637 4 4 1.000 0.006 GO:0009968 BP 1 negative regulation of signal transduction 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 3.78e-05 661 4 4 1.000 0.006 GO:0010648 BP 1 negative regulation of cell communication 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 3.87e-05 665 4 4 1.000 0.006 GO:0023057 BP 1 negative regulation of signaling 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 4.72e-05 174 4 3 0.750 0.017 GO:0007178 BP 1 transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q9HAU4,Q8NFG4,O15165 144 7.15e-05 775 4 4 1.000 0.005 GO:0048585 BP 1 negative regulation of response to stimulus 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 2.23e-04 38 4 2 0.500 0.053 GO:1903845 BP 1 negative regulation of cellular response to transforming growth factor beta stimulus 1 Q9HAU4,O15165 144 2.23e-04 38 4 2 0.500 0.053 GO:0030512 BP 1 negative regulation of transforming growth factor beta receptor signaling pathway 1 Q9HAU4,O15165 144 2.82e-04 316 4 3 0.750 0.009 GO:0071363 BP 1 cellular response to growth factor stimulus 1 Q9HAU4,Q8NFG4,O15165 144 3.00e-04 44 4 2 0.500 0.045 GO:0046332 MF 1 SMAD binding 1 Q9HAU4,O15165 144 3.10e-04 326 4 3 0.750 0.009 GO:0070848 BP 1 response to growth factor 1 Q9HAU4,Q8NFG4,O15165 144 4.52e-04 370 4 3 0.750 0.008 GO:0030334 BP 1 regulation of cell migration 1 Q9HAU4,Q8NFG4,O15165 144 4.54e-04 54 4 2 0.500 0.037 GO:0090101 BP 1 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q9HAU4,O15165 144 5.87e-04 404 4 3 0.750 0.007 GO:2000145 BP 1 regulation of cell motility 1 Q9HAU4,Q8NFG4,O15165 144 6.18e-04 63 4 2 0.500 0.032 GO:0090288 BP 1 negative regulation of cellular response to growth factor stimulus 1 Q9HAU4,O15165 144 7.47e-04 438 4 3 0.750 0.007 GO:0051270 BP 1 regulation of cellular component movement 1 Q9HAU4,Q8NFG4,O15165 144 7.68e-04 442 4 3 0.750 0.007 GO:0040012 BP 1 regulation of locomotion 1 Q9HAU4,Q8NFG4,O15165 144 8.00e-04 1416 4 4 1.000 0.003 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.22e-03 1573 4 4 1.000 0.003 GO:0009966 BP 1 regulation of signal transduction 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.23e-03 1 4 1 0.250 1.000 GO:2000506 BP 1 negative regulation of energy homeostasis 1 Q8NFG4 144 1.63e-03 1691 4 4 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.75e-03 1 4 1 0.250 1.000 OMIM:173600 omi 1 PNEUMOTHORAX, PRIMARY SPONTANEOUS;;PSP 1 Q8NFG4 144 1.75e-03 1 4 1 0.250 1.000 OMIM:135150 omi 1 BIRT-HOGG-DUBE SYNDROME; BHD;;HORNSTEIN-KNICKENBERG SYNDROME;;FIBROFOLLICULOMAS WITH TRICHODISCOMAS AND ACROCHORDONS 1 Q8NFG4 144 1.78e-03 1728 4 4 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.84e-03 593 4 3 0.750 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q9HAU4,Q8NFG4,O15165 144 2.06e-03 115 4 2 0.500 0.017 GO:0030336 BP 1 negative regulation of cell migration 1 Q8NFG4,O15165 144 2.14e-03 117 4 2 0.500 0.017 GO:0061630 MF 1 ubiquitin protein ligase activity 1 Q76N89,Q9HAU4 144 2.28e-03 121 4 2 0.500 0.017 GO:0061659 MF 1 ubiquitin-like protein ligase activity 1 Q76N89,Q9HAU4 144 2.28e-03 121 4 2 0.500 0.017 GO:2000146 BP 1 negative regulation of cell motility 1 Q8NFG4,O15165 144 2.30e-03 640 4 3 0.750 0.005 GO:0016477 BP 1 cell migration 1 Q9HAU4,Q8NFG4,O15165 144 2.34e-03 643 4 3 0.750 0.005 GO:0071495 BP 1 cellular response to endogenous stimulus 1 Q9HAU4,Q8NFG4,O15165 144 2.45e-03 2 4 1 0.250 0.500 GO:1901723 BP 1 negative regulation of cell proliferation involved in kidney development 1 Q8NFG4 144 2.45e-03 2 4 1 0.250 0.500 GO:0010990 BP 1 regulation of SMAD protein complex assembly 1 O15165 144 2.45e-03 2 4 1 0.250 0.500 GO:0010991 BP 1 negative regulation of SMAD protein complex assembly 1 O15165 144 3.10e-03 141 4 2 0.500 0.014 GO:0051271 BP 1 negative regulation of cellular component movement 1 Q8NFG4,O15165 144 3.15e-03 711 4 3 0.750 0.004 GO:0051674 BP 1 localization of cell 1 Q9HAU4,Q8NFG4,O15165 144 3.15e-03 711 4 3 0.750 0.004 GO:0048870 BP 1 cell motility 1 Q9HAU4,Q8NFG4,O15165 144 3.16e-03 712 4 3 0.750 0.004 GO:0009719 BP 1 response to endogenous stimulus 1 Q9HAU4,Q8NFG4,O15165 144 3.60e-03 152 4 2 0.500 0.013 GO:0040013 BP 1 negative regulation of locomotion 1 Q8NFG4,O15165 144 3.68e-03 3 4 1 0.250 0.333 GO:2001170 BP 1 negative regulation of ATP biosynthetic process 1 Q8NFG4 144 3.68e-03 3 4 1 0.250 0.333 GO:1901165 BP 1 positive regulation of trophoblast cell migration 1 Q9HAU4 144 3.88e-03 2101 4 4 1.000 0.002 GO:0048583 BP 1 regulation of response to stimulus 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 4.04e-03 774 4 3 0.750 0.004 GO:2000026 BP 1 regulation of multicellular organismal development 1 Q9HAU4,Q8NFG4,O15165 144 4.08e-03 162 4 2 0.500 0.012 GO:0060828 BP 1 regulation of canonical Wnt signaling pathway 1 Q76N89,Q9HAU4 144 4.69e-03 814 4 3 0.750 0.004 GO:0040011 BP 1 locomotion 1 Q9HAU4,Q8NFG4,O15165 144 4.90e-03 4 4 1 0.250 0.250 GO:2000973 BP 1 regulation of pro-B cell differentiation 1 Q8NFG4 144 4.90e-03 4 4 1 0.250 0.250 GO:1901163 BP 1 regulation of trophoblast cell migration 1 Q9HAU4 144 4.90e-03 4 4 1 0.250 0.250 GO:0061450 BP 1 trophoblast cell migration 1 Q9HAU4 144 4.90e-03 4 4 1 0.250 0.250 GO:2001169 BP 1 regulation of ATP biosynthetic process 1 Q8NFG4 144 5.31e-03 185 4 2 0.500 0.011 GO:0042787 BP 1 protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q76N89,Q9HAU4 144 5.34e-03 2275 4 4 1.000 0.002 GO:0036211 BP 1 protein modification process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 5.34e-03 2275 4 4 1.000 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 5.66e-03 191 4 2 0.500 0.010 GO:0060070 BP 1 canonical Wnt signaling pathway 1 Q76N89,Q9HAU4 144 6.13e-03 5 4 1 0.250 0.200 GO:0090185 BP 1 negative regulation of kidney development 1 Q8NFG4 144 6.13e-03 5 4 1 0.250 0.200 GO:1905456 BP 1 regulation of lymphoid progenitor cell differentiation 1 Q8NFG4 144 6.13e-03 5 4 1 0.250 0.200 GO:0030579 BP 1 ubiquitin-dependent SMAD protein catabolic process 1 Q9HAU4 144 6.13e-03 5 4 1 0.250 0.200 GO:0002328 BP 1 pro-B cell differentiation 1 Q8NFG4 144 6.13e-03 5 4 1 0.250 0.200 GO:0060394 BP 1 negative regulation of pathway-restricted SMAD protein phosphorylation 1 O15165 144 6.80e-03 2417 4 4 1.000 0.002 GO:0043412 BP 1 macromolecule modification 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 6.83e-03 210 4 2 0.500 0.010 GO:0030111 BP 1 regulation of Wnt signaling pathway 1 Q76N89,Q9HAU4 144 6.97e-03 2432 4 4 1.000 0.002 GO:0048523 BP 1 negative regulation of cellular process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 7.35e-03 6 4 1 0.250 0.167 GO:0002320 BP 1 lymphoid progenitor cell differentiation 1 Q8NFG4 144 7.35e-03 6 4 1 0.250 0.167 GO:1901722 BP 1 regulation of cell proliferation involved in kidney development 1 Q8NFG4 144 7.62e-03 222 4 2 0.500 0.009 GO:0001933 BP 1 negative regulation of protein phosphorylation 1 Q8NFG4,O15165 144 9.00e-03 1016 4 3 0.750 0.003 GO:0006928 BP 1 movement of cell or subcellular component 1 Q9HAU4,Q8NFG4,O15165 144 9.34e-03 246 4 2 0.500 0.008 GO:0042326 BP 1 negative regulation of phosphorylation 1 Q8NFG4,O15165 144 9.36e-03 2618 4 4 1.000 0.002 GO:0048519 BP 1 negative regulation of biological process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 9.80e-03 8 4 1 0.250 0.125 GO:0035024 BP 1 negative regulation of Rho protein signal transduction 1 Q8NFG4 144 9.80e-03 8 4 1 0.250 0.125 GO:2000505 BP 1 regulation of energy homeostasis 1 Q8NFG4 144 1.04e-02 1067 4 3 0.750 0.003 GO:0050793 BP 1 regulation of developmental process 1 Q9HAU4,Q8NFG4,O15165 144 1.10e-02 9 4 1 0.250 0.111 GO:0072111 BP 1 cell proliferation involved in kidney development 1 Q8NFG4 144 1.10e-02 9 4 1 0.250 0.111 GO:1901532 BP 1 regulation of hematopoietic progenitor cell differentiation 1 Q8NFG4 144 1.18e-02 1113 4 3 0.750 0.003 GO:0048513 BP 1 animal organ development 1 Q9HAU4,Q8NFG4,O15165 144 1.22e-02 10 4 1 0.250 0.100 GO:0007183 BP 1 SMAD protein complex assembly 1 O15165 144 1.22e-02 10 4 1 0.250 0.100 GO:0045978 BP 1 negative regulation of nucleoside metabolic process 1 Q8NFG4 144 1.22e-02 10 4 1 0.250 0.100 GO:1903579 BP 1 negative regulation of ATP metabolic process 1 Q8NFG4 144 1.22e-02 10 4 1 0.250 0.100 GO:0007566 BP 1 embryo implantation 1 Q9HAU4 144 1.30e-02 165 4 2 0.500 0.012 REAC:201681 rea 1 TCF dependent signaling in response to WNT 1 Q76N89,Q9HAU4 144 1.32e-02 1157 4 3 0.750 0.003 GO:0071310 BP 1 cellular response to organic substance 1 Q9HAU4,Q8NFG4,O15165 144 1.35e-02 11 4 1 0.250 0.091 GO:0097009 BP 1 energy homeostasis 1 Q8NFG4 144 1.39e-02 301 4 2 0.500 0.007 GO:0198738 BP 1 cell-cell signaling by wnt 1 Q76N89,Q9HAU4 144 1.39e-02 301 4 2 0.500 0.007 GO:0016055 BP 1 Wnt signaling pathway 1 Q76N89,Q9HAU4 144 1.40e-02 8 4 1 0.250 0.125 OMIM:144700 omi 1 Renal Cell Carcinoma 1 Q8NFG4 144 1.40e-02 302 4 2 0.500 0.007 GO:0004842 MF 1 ubiquitin-protein transferase activity 1 Q76N89,Q9HAU4 144 1.47e-02 12 4 1 0.250 0.083 GO:2000243 BP 1 positive regulation of reproductive process 1 Q9HAU4 144 1.55e-02 318 4 2 0.500 0.006 GO:0019787 MF 1 ubiquitin-like protein transferase activity 1 Q76N89,Q9HAU4 144 1.59e-02 322 4 2 0.500 0.006 GO:0045936 BP 1 negative regulation of phosphate metabolic process 1 Q8NFG4,O15165 144 1.59e-02 2990 4 4 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.60e-02 323 4 2 0.500 0.006 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 Q76N89,Q9HAU4 144 1.60e-02 323 4 2 0.500 0.006 GO:0010563 BP 1 negative regulation of phosphorus metabolic process 1 Q8NFG4,O15165 144 1.62e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 1.70e-02 1263 4 3 0.750 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 Q9HAU4,Q8NFG4,O15165 144 1.74e-02 337 4 2 0.500 0.006 GO:0051093 BP 1 negative regulation of developmental process 1 Q8NFG4,O15165 144 1.84e-02 15 4 1 0.250 0.067 GO:0010719 BP 1 negative regulation of epithelial to mesenchymal transition 1 O15165 144 1.84e-02 15 4 1 0.250 0.067 GO:0070412 MF 1 R-SMAD binding 1 O15165 144 1.89e-02 1310 4 3 0.750 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 Q9HAU4,Q8NFG4,O15165 144 1.92e-02 1317 4 3 0.750 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 Q9HAU4,Q8NFG4,O15165 144 1.97e-02 359 4 2 0.500 0.006 GO:0051129 BP 1 negative regulation of cellular component organization 1 Q8NFG4,O15165 144 2.02e-02 1340 4 3 0.750 0.002 GO:0032879 BP 1 regulation of localization 1 Q9HAU4,Q8NFG4,O15165 144 2.05e-02 3185 4 4 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 2.08e-02 17 4 1 0.250 0.059 GO:1903846 BP 1 positive regulation of cellular response to transforming growth factor beta stimulus 1 Q8NFG4 144 2.08e-02 17 4 1 0.250 0.059 GO:0002244 BP 1 hematopoietic progenitor cell differentiation 1 Q8NFG4 144 2.08e-02 17 4 1 0.250 0.059 GO:1900372 BP 1 negative regulation of purine nucleotide biosynthetic process 1 Q8NFG4 144 2.08e-02 17 4 1 0.250 0.059 GO:0030511 BP 1 positive regulation of transforming growth factor beta receptor signaling pathway 1 Q8NFG4 144 2.08e-02 17 4 1 0.250 0.059 GO:0030809 BP 1 negative regulation of nucleotide biosynthetic process 1 Q8NFG4 144 2.09e-02 370 4 2 0.500 0.005 GO:0031400 BP 1 negative regulation of protein modification process 1 Q8NFG4,O15165 144 2.14e-02 375 4 2 0.500 0.005 GO:0000122 BP 1 negative regulation of transcription from RNA polymerase II promoter 1 Q9HAU4,Q8NFG4 144 2.26e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 2.27e-02 1394 4 3 0.750 0.002 GO:0010033 BP 1 response to organic substance 1 Q9HAU4,Q8NFG4,O15165 144 2.27e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 2.29e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 2.41e-02 1423 4 3 0.750 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q9HAU4,Q8NFG4,O15165 144 2.41e-02 1424 4 3 0.750 0.002 GO:0009892 BP 1 negative regulation of metabolic process 1 Q9HAU4,Q8NFG4,O15165 144 2.48e-02 404 4 2 0.500 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q76N89,Q9HAU4 144 2.50e-02 1 4 1 0.250 1.000 CORUM:2992 cor 1 SMAD7-SMURF2 complex 1 Q9HAU4 144 2.52e-02 408 4 2 0.500 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q76N89,Q9HAU4 144 2.62e-02 416 4 2 0.500 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q76N89,Q9HAU4 144 2.65e-02 418 4 2 0.500 0.005 GO:0051241 BP 1 negative regulation of multicellular organismal process 1 Q8NFG4,O15165 144 2.69e-02 22 4 1 0.250 0.045 GO:0090183 BP 1 regulation of kidney development 1 Q8NFG4 144 2.69e-02 22 4 1 0.250 0.045 GO:0046580 BP 1 negative regulation of Ras protein signal transduction 1 Q8NFG4 144 2.69e-02 22 4 1 0.250 0.045 GO:0051898 BP 1 negative regulation of protein kinase B signaling 1 Q8NFG4 144 2.81e-02 23 4 1 0.250 0.043 GO:0051058 BP 1 negative regulation of small GTPase mediated signal transduction 1 Q8NFG4 144 2.88e-02 247 4 2 0.500 0.008 REAC:195721 rea 1 Signaling by Wnt 1 Q76N89,Q9HAU4 144 3.06e-02 25 4 1 0.250 0.040 GO:0032008 BP 1 positive regulation of TOR signaling 1 Q8NFG4 144 3.18e-02 26 4 1 0.250 0.038 GO:1900543 BP 1 negative regulation of purine nucleotide metabolic process 1 Q8NFG4 144 3.18e-02 26 4 1 0.250 0.038 GO:0010823 BP 1 negative regulation of mitochondrion organization 1 Q8NFG4 144 3.18e-02 26 4 1 0.250 0.038 GO:2000241 BP 1 regulation of reproductive process 1 Q9HAU4 144 3.18e-02 459 4 2 0.500 0.004 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q76N89,Q9HAU4 144 3.19e-02 2286 4 3 0.750 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q76N89,Q8NFG4,O15165 144 3.22e-02 462 4 2 0.500 0.004 GO:0016567 BP 1 protein ubiquitination 1 Q76N89,Q9HAU4 144 3.30e-02 27 4 1 0.250 0.037 GO:0032007 BP 1 negative regulation of TOR signaling 1 Q8NFG4 144 3.30e-02 27 4 1 0.250 0.037 GO:0045980 BP 1 negative regulation of nucleotide metabolic process 1 Q8NFG4 144 3.52e-02 484 4 2 0.500 0.004 GO:0044257 BP 1 cellular protein catabolic process 1 Q76N89,Q9HAU4 144 3.66e-02 30 4 1 0.250 0.033 GO:0035065 BP 1 regulation of histone acetylation 1 Q8NFG4 144 3.79e-02 31 4 1 0.250 0.032 GO:1903578 BP 1 regulation of ATP metabolic process 1 Q8NFG4 144 3.79e-02 31 4 1 0.250 0.032 GO:2000756 BP 1 regulation of peptidyl-lysine acetylation 1 Q8NFG4 144 3.79e-02 31 4 1 0.250 0.032 GO:0009118 BP 1 regulation of nucleoside metabolic process 1 Q8NFG4 144 3.91e-02 32 4 1 0.250 0.031 GO:0070373 BP 1 negative regulation of ERK1 and ERK2 cascade 1 Q8NFG4 144 3.91e-02 32 4 1 0.250 0.031 GO:0044291 CC 1 cell-cell contact zone 1 Q8NFG4 144 3.97e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 Q76N89,Q9HAU4,Q8NFG4,O15165 144 4.03e-02 33 4 1 0.250 0.030 GO:0035023 BP 1 regulation of Rho protein signal transduction 1 Q8NFG4 144 4.15e-02 34 4 1 0.250 0.029 GO:1901983 BP 1 regulation of protein acetylation 1 Q8NFG4 144 4.27e-02 35 4 1 0.250 0.029 GO:0006754 BP 1 ATP biosynthetic process 1 Q8NFG4 144 4.51e-02 37 4 1 0.250 0.027 GO:0007565 BP 1 female pregnancy 1 Q9HAU4 144 4.51e-02 37 4 1 0.250 0.027 GO:0009206 BP 1 purine ribonucleoside triphosphate biosynthetic process 1 Q8NFG4 144 4.51e-02 37 4 1 0.250 0.027 GO:0060393 BP 1 regulation of pathway-restricted SMAD protein phosphorylation 1 O15165 144 4.51e-02 37 4 1 0.250 0.027 GO:0009145 BP 1 purine nucleoside triphosphate biosynthetic process 1 Q8NFG4 144 4.53e-02 19 4 1 0.250 0.053 REAC:201451 rea 1 Signaling by BMP 1 Q9HAU4 144 4.64e-02 38 4 1 0.250 0.026 GO:0009201 BP 1 ribonucleoside triphosphate biosynthetic process 1 Q8NFG4 144 4.64e-02 38 4 1 0.250 0.026 GO:0001701 BP 1 in utero embryonic development 1 Q8NFG4 144 4.67e-02 560 4 2 0.500 0.004 GO:0030163 BP 1 protein catabolic process 1 Q76N89,Q9HAU4 144 4.81e-02 1810 4 3 0.750 0.002 GO:0048731 BP 1 system development 1 Q9HAU4,Q8NFG4,O15165 144 4.87e-02 572 4 2 0.500 0.003 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 Q8NFG4,O15165 144 4.88e-02 40 4 1 0.250 0.025 GO:0060389 BP 1 pathway-restricted SMAD protein phosphorylation 1 O15165 144 4.89e-02 573 4 2 0.500 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q76N89,Q9HAU4 144 5.00e-02 21 4 1 0.250 0.048 REAC:2173788 rea 1 Downregulation of TGF-beta receptor signaling 1 Q9HAU4 144 5.00e-02 41 4 1 0.250 0.024 GO:0044706 BP 1 multi-multicellular organism process 1 Q9HAU4 144 5.00e-02 37 4 1 0.250 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q9HAU4 144 5.00e-02 21 4 1 0.250 0.048 REAC:2173795 rea 1 Downregulation of SMAD2/3:SMAD4 transcriptional activity 1 Q9HAU4 144 5.00e-02 29 4 1 0.250 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 Q8NFG4 144 5.00e-02 799 4 3 0.750 0.004 TF:M07371_0 tf 1 Factor: ZEB; motif: NNNCAGGTGNSN; match class: 0 1 Q9HAU4,Q8NFG4,O15165 144 5.00e-02 2 4 1 0.250 0.500 CORUM:1784 cor 1 RNF11-SMURF2-STAMBP complex 1 Q9HAU4 144 5.00e-02 1 4 1 0.250 1.000 HP:0030436 hp 1 Fibrofolliculoma 1 Q8NFG4 145 5.37e-06 49 4 3 0.750 0.061 GO:0031463 CC 1 Cul3-RING ubiquitin ligase complex 1 Q13618,Q9P2K6,Q6TFL4 145 1.22e-04 137 4 3 0.750 0.022 GO:0031461 CC 1 cullin-RING ubiquitin ligase complex 1 Q13618,Q9P2K6,Q6TFL4 145 5.47e-04 226 4 3 0.750 0.013 GO:0000151 CC 1 ubiquitin ligase complex 1 Q13618,Q9P2K6,Q6TFL4 145 1.30e-03 302 4 3 0.750 0.010 GO:0004842 MF 1 ubiquitin-protein transferase activity 1 Q13618,Q9P2K6,Q6TFL4 145 1.52e-03 318 4 3 0.750 0.009 GO:0019787 MF 1 ubiquitin-like protein transferase activity 1 Q13618,Q9P2K6,Q6TFL4 145 3.09e-03 294 4 2 0.500 0.007 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 Q13618,Q7Z5Y7 145 3.45e-03 3086 4 4 1.000 0.001 TF:M07265_0 tf 1 Factor: Nrf2; motif: NNTGACTCAGCAN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 4.66e-03 307 4 2 0.500 0.007 HPA:004010_03 hpa 1 breast; adipocytes[Uncertain,High] 1 Q13618,Q7Z5Y7 145 5.33e-03 3440 4 4 1.000 0.001 TF:M04306_1 tf 1 Factor: DPRX; motif: NNGGATTANN; match class: 1 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 5.65e-03 18 4 1 0.250 0.056 TF:M05576_0 tf 1 Factor: ZFP92; motif: NCGATAAAATGM; match class: 0 1 Q6TFL4 145 5.65e-03 18 4 1 0.250 0.056 TF:M05832_0 tf 1 Factor: ZNF620; motif: NGCTKWAAACGM; match class: 0 1 Q13618 145 5.87e-03 1492 4 3 0.750 0.002 TF:M01002_0 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 0 1 Q13618,Q9P2K6,Q6TFL4 145 6.09e-03 352 4 2 0.500 0.006 HPA:039010_03 hpa 1 soft tissue 1; adipocytes[Uncertain,High] 1 Q13618,Q7Z5Y7 145 6.27e-03 20 4 1 0.250 0.050 TF:M00248_0 tf 1 Factor: Oct-1; motif: TNTATGBTAATT; match class: 0 1 Q13618 145 6.49e-03 1 4 1 0.250 1.000 GO:0040016 BP 1 embryonic cleavage 1 Q13618 145 6.49e-03 1 4 1 0.250 1.000 GO:0031208 MF 1 POZ domain binding 1 Q13618 145 6.64e-03 1557 4 3 0.750 0.002 TF:M07044_1 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 1 Q13618,Q7Z5Y7,Q6TFL4 145 7.01e-03 446 4 2 0.500 0.004 TF:M07265_1 tf 1 Factor: Nrf2; motif: NNTGACTCAGCAN; match class: 1 1 Q13618,Q7Z5Y7 145 7.22e-03 384 4 2 0.500 0.005 HPA:040010_03 hpa 1 soft tissue 2; adipocytes[Uncertain,High] 1 Q13618,Q7Z5Y7 145 9.25e-03 1746 4 3 0.750 0.002 TF:M00006_0 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 0 1 Q9P2K6,Q7Z5Y7,Q6TFL4 145 9.54e-03 1765 4 3 0.750 0.002 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q13618,Q7Z5Y7,Q6TFL4 145 1.05e-02 272 4 2 0.500 0.007 REAC:983168 rea 1 Antigen processing: Ubiquitination & Proteasome degradation 1 Q13618,Q9P2K6 145 1.06e-02 34 4 1 0.250 0.029 TF:M06143_0 tf 1 Factor: ZNF16; motif: NGTKGCTTAAKA; match class: 0 1 Q13618 145 1.13e-02 624 4 3 0.750 0.005 GO:1990234 CC 1 transferase complex 1 Q13618,Q9P2K6,Q6TFL4 145 1.25e-02 1 4 1 0.250 1.000 OMIM:614496 omi 1 PSEUDOHYPOALDOSTERONISM, TYPE IIE; PHA2E 1 Q13618 145 1.32e-02 1975 4 3 0.750 0.002 TF:M07340_1 tf 1 Factor: TEF-1; motif: ACATTCCWSNN; match class: 1 1 Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.41e-02 4387 4 4 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.45e-02 322 4 2 0.500 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q13618,Q9P2K6 145 1.50e-02 4457 4 4 1.000 0.001 TF:M03844_0 tf 1 Factor: SAP-1a; motif: CWTCCKGT; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.50e-02 4457 4 4 1.000 0.001 TF:M07282_0 tf 1 Factor: ER71; motif: CWTCCTGT; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.56e-02 50 4 1 0.250 0.020 TF:M05674_0 tf 1 Factor: ZNF235; motif: NGGTTAAAGATM; match class: 0 1 Q13618 145 1.57e-02 2098 4 3 0.750 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q13618,Q9P2K6,Q6TFL4 145 1.59e-02 2110 4 3 0.750 0.001 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 Q13618,Q9P2K6,Q6TFL4 145 1.72e-02 55 4 1 0.250 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q9P2K6 145 1.80e-02 4665 4 4 1.000 0.001 TF:M00117_1 tf 1 Factor: C/EBPbeta; motif: NKNTTGCNYAAYNN; match class: 1 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.81e-02 58 4 1 0.250 0.017 TF:M03912_0 tf 1 Factor: KLF13; motif: NTGMCACGCCCCTTTTTG; match class: 0 1 Q13618 145 1.85e-02 2223 4 3 0.750 0.001 TF:M07258_0 tf 1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 0 1 Q9P2K6,Q7Z5Y7,Q6TFL4 145 1.88e-02 3 4 1 0.250 0.333 CORUM:1225 cor 1 Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) 1 Q13618 145 1.88e-02 3 4 1 0.250 0.333 CORUM:1243 cor 1 Ubiquitin E3 ligase (SPOP, DAXX, CUL3) 1 Q13618 145 1.88e-02 3 4 1 0.250 0.333 CORUM:222 cor 1 CAND1-CUL3-RBX1 complex 1 Q13618 145 1.88e-02 3 4 1 0.250 0.333 CORUM:1224 cor 1 Ubiquitin E3 ligase (BMI1, SPOP, CUL3) 1 Q13618 145 1.95e-02 2264 4 3 0.750 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q13618,Q9P2K6,Q7Z5Y7 145 1.97e-02 63 4 1 0.250 0.016 TF:M06611_0 tf 1 Factor: ZNF560; motif: NNGTGGGKCAGC; match class: 0 1 Q9P2K6 145 2.07e-02 2314 4 3 0.750 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 Q9P2K6,Q7Z5Y7,Q6TFL4 145 2.14e-02 1985 4 3 0.750 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q13618,Q9P2K6,Q7Z5Y7 145 2.16e-02 4879 4 4 1.000 0.001 TF:M07319_0 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 2.31e-02 74 4 1 0.250 0.014 TF:M06627_0 tf 1 Factor: ZNF570; motif: NTGTWAARCATA; match class: 0 1 Q13618 145 2.34e-02 75 4 1 0.250 0.013 TF:M06020_0 tf 1 Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 0 1 Q9P2K6 145 2.35e-02 2051 4 3 0.750 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q13618,Q9P2K6,Q7Z5Y7 145 2.35e-02 834 4 2 0.500 0.002 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 Q13618,Q9P2K6 145 2.43e-02 78 4 1 0.250 0.013 TF:M05949_0 tf 1 Factor: ZNF714; motif: NGGGAAGGAAGM; match class: 0 1 Q9P2K6 145 2.51e-02 4 4 1 0.250 0.250 HP:0011423 hp 1 Hyperchloremia 1 Q13618 145 2.78e-02 2565 4 3 0.750 0.001 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7 145 2.80e-02 90 4 1 0.250 0.011 TF:M06038_0 tf 1 Factor: TCF17; motif: NGKGGAAWAAKM; match class: 0 1 Q7Z5Y7 145 2.86e-02 5233 4 4 1.000 0.001 TF:M07379_0 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 2.86e-02 92 4 1 0.250 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 Q9P2K6 145 2.93e-02 936 4 2 0.500 0.002 TF:M04184_0 tf 1 Factor: NHLH1; motif: CGCAGCTGCK; match class: 0 1 Q9P2K6,Q6TFL4 145 2.99e-02 802 4 2 0.500 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q13618,Q7Z5Y7 145 3.07e-02 959 4 2 0.500 0.002 TF:M01817_1 tf 1 Factor: TEF-1; motif: GWGGAATGT; match class: 1 1 Q7Z5Y7,Q6TFL4 145 3.14e-02 5358 4 4 1.000 0.001 TF:M01011_0 tf 1 Factor: HNF1; motif: NNNNGNTAAWNATTAACYNNN; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 3.20e-02 103 4 1 0.250 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q9P2K6 145 3.24e-02 5 4 1 0.250 0.200 GO:0005827 CC 1 polar microtubule 1 Q13618 145 3.26e-02 105 4 1 0.250 0.010 TF:M07415_0 tf 1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 0 1 Q7Z5Y7 145 3.47e-02 867 4 2 0.500 0.002 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 Q13618,Q7Z5Y7 145 3.47e-02 112 4 1 0.250 0.009 TF:M04363_1 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 1 1 Q6TFL4 145 3.47e-02 112 4 1 0.250 0.009 TF:M04357_1 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 1 1 Q6TFL4 145 3.56e-02 879 4 2 0.500 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q13618,Q7Z5Y7 145 3.57e-02 2804 4 3 0.750 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 Q13618,Q9P2K6,Q6TFL4 145 3.72e-02 213 4 2 0.500 0.009 GO:0000209 BP 1 protein polyubiquitination 1 Q13618,Q9P2K6 145 3.89e-02 6 4 1 0.250 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q13618 145 3.89e-02 6 4 1 0.250 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q13618 145 3.89e-02 6 4 1 0.250 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q13618 145 3.91e-02 55 4 1 0.250 0.018 REAC:4641258 rea 1 Degradation of DVL 1 Q13618 145 3.98e-02 2917 4 3 0.750 0.001 TF:M02078_1 tf 1 Factor: SPI1; motif: NGRGGAAGTN; match class: 1 1 Q13618,Q9P2K6,Q7Z5Y7 145 4.06e-02 943 4 2 0.500 0.002 HPA:035040_03 hpa 1 skin 1; melanocytes[Uncertain,High] 1 Q13618,Q7Z5Y7 145 4.13e-02 1122 4 2 0.500 0.002 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 Q9P2K6,Q7Z5Y7 145 4.27e-02 1142 4 2 0.500 0.002 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 Q9P2K6,Q6TFL4 145 4.30e-02 139 4 1 0.250 0.007 TF:M05366_0 tf 1 Factor: Tbr-1; motif: TTNACACCTR; match class: 0 1 Q6TFL4 145 4.30e-02 139 4 1 0.250 0.007 TF:M05495_0 tf 1 Factor: T-bet; motif: TTAACACCTA; match class: 0 1 Q6TFL4 145 4.30e-02 139 4 1 0.250 0.007 TF:M05321_0 tf 1 Factor: TBR2; motif: TTNACACCTR; match class: 0 1 Q6TFL4 145 4.34e-02 3008 4 3 0.750 0.001 TF:M00232_0 tf 1 Factor: MEF-2A; motif: NNNNNWKCTAWAAATAGMNNNN; match class: 0 1 Q13618,Q9P2K6,Q6TFL4 145 4.51e-02 1176 4 2 0.500 0.002 TF:M01124_0 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 0 1 Q13618,Q9P2K6 145 4.52e-02 3052 4 3 0.750 0.001 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q13618,Q9P2K6,Q6TFL4 145 4.68e-02 66 4 1 0.250 0.015 REAC:5658442 rea 1 Regulation of RAS by GAPs 1 Q13618 145 4.95e-02 136 4 1 0.250 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q13618 145 4.96e-02 6006 4 4 1.000 0.001 TF:M00189_1 tf 1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 1 Q13618,Q9P2K6,Q7Z5Y7,Q6TFL4 145 4.96e-02 3155 4 3 0.750 0.001 TF:M01253_0 tf 1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 0 1 Q13618,Q9P2K6,Q7Z5Y7 145 5.00e-02 8 4 1 0.250 0.125 CORUM:2715 cor 1 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) 1 Q13618 145 5.00e-02 614 4 2 0.500 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 Q13618,Q9P2K6 145 5.00e-02 37 4 1 0.250 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q13618 145 5.00e-02 4 4 1 0.250 0.250 OMIM:145260 omi 1 Pseudohypoaldosteronism Type II 1 Q13618 145 5.00e-02 1033 4 3 0.750 0.003 GO:1902494 CC 1 catalytic complex 1 Q13618,Q9P2K6,Q6TFL4 145 5.00e-02 8 4 1 0.250 0.125 HP:0008242 hp 1 Pseudohypoaldosteronism 1 Q13618 146 1.48e-03 490 2 2 1.000 0.004 TF:M06081_0 tf 1 Factor: ZNF99; motif: TAGCTGRACA; match class: 0 1 Q68CQ7,Q96MM7 146 6.75e-03 43 2 1 0.500 0.023 TF:M05418_0 tf 1 Factor: ZNF521; motif: NKGGGGGCCGGA; match class: 0 1 Q68CQ7 146 1.04e-02 1301 2 2 1.000 0.002 TF:M02219_0 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 0 1 Q68CQ7,Q96MM7 146 1.13e-02 72 2 1 0.500 0.014 TF:M06561_0 tf 1 Factor: ZNF502; motif: NGGGWAAGACT; match class: 0 1 Q96MM7 146 1.25e-02 3 2 1 0.500 0.333 GO:0017095 MF 1 heparan sulfate 6-O-sulfotransferase activity 1 Q96MM7 146 1.34e-02 1476 2 2 1.000 0.001 TF:M02110_1 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 1 1 Q68CQ7,Q96MM7 146 1.39e-02 1499 2 2 1.000 0.001 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 Q68CQ7,Q96MM7 146 1.41e-02 28 2 1 0.500 0.036 REAC:2022928 rea 1 HS-GAG biosynthesis 1 Q96MM7 146 1.64e-02 105 2 1 0.500 0.010 TF:M03984_0 tf 1 Factor: ETV6; motif: CCGGAASCGGAAGTR; match class: 0 1 Q68CQ7 146 1.67e-02 107 2 1 0.500 0.009 TF:M01007_0 tf 1 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN; match class: 0 1 Q96MM7 146 1.76e-02 1688 2 2 1.000 0.001 TF:M07426_0 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 0 1 Q68CQ7,Q96MM7 146 1.77e-02 1693 2 2 1.000 0.001 TF:M01826_0 tf 1 Factor: PITX1; motif: GMMACTAATCY; match class: 0 1 Q68CQ7,Q96MM7 146 2.08e-02 5 2 1 0.500 0.200 GO:0015015 BP 1 heparan sulfate proteoglycan biosynthetic process, enzymatic modification 1 Q96MM7 146 2.09e-02 134 2 1 0.500 0.007 TF:M00186_0 tf 1 Factor: SRF; motif: GNCCAWATAWGGMN; match class: 0 1 Q96MM7 146 2.31e-02 46 2 1 0.500 0.022 REAC:1638091 rea 1 Heparan sulfate/heparin (HS-GAG) metabolism 1 Q96MM7 146 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 Q68CQ7 146 2.51e-02 2018 2 2 1.000 0.001 TF:M07283_1 tf 1 Factor: ER-alpha; motif: GNCNNNNTGACCYN; match class: 1 1 Q68CQ7,Q96MM7 146 2.54e-02 163 2 1 0.500 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 Q68CQ7 146 2.82e-02 181 2 1 0.500 0.006 TF:M07227_0 tf 1 Factor: SRF; motif: NNTKNCCAWATAWGGNAA; match class: 0 1 Q96MM7 146 2.87e-02 184 2 1 0.500 0.005 TF:M05438_0 tf 1 Factor: Osx; motif: WGGGCGGGTS; match class: 0 1 Q68CQ7 146 3.02e-02 2213 2 2 1.000 0.001 TF:M00191_0 tf 1 Factor: ER; motif: NNARGNCANNNTGACCYNN; match class: 0 1 Q68CQ7,Q96MM7 146 3.30e-02 2314 2 2 1.000 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 Q68CQ7,Q96MM7 146 3.31e-02 2317 2 2 1.000 0.001 TF:M00920_0 tf 1 Factor: E2F; motif: NKCGCGCSAAAN; match class: 0 1 Q68CQ7,Q96MM7 146 3.38e-02 217 2 1 0.500 0.005 TF:M05956_1 tf 1 Factor: CTIP-2; motif: RTMGTACAA; match class: 1 1 Q68CQ7 146 3.38e-02 217 2 1 0.500 0.005 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 Q96MM7 146 3.52e-02 226 2 1 0.500 0.004 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q68CQ7 146 3.54e-02 227 2 1 0.500 0.004 TF:M00465_0 tf 1 Factor: POU6F1; motif: GCATAAWTTAT; match class: 0 1 Q68CQ7 146 3.63e-02 233 2 1 0.500 0.004 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 Q68CQ7 146 3.66e-02 2436 2 2 1.000 0.001 TF:M01001_0 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 0 1 Q68CQ7,Q96MM7 146 3.78e-02 243 2 1 0.500 0.004 TF:M07424_1 tf 1 Factor: MEF-2; motif: NNYTATTTTTAGN; match class: 1 1 Q68CQ7 146 3.83e-02 2492 2 2 1.000 0.001 TF:M05347_0 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 0 1 Q68CQ7,Q96MM7 146 3.94e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 Q68CQ7,Q96MM7 146 4.12e-02 265 2 1 0.500 0.004 TF:M01735_1 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 1 1 Q68CQ7 146 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 Q68CQ7 146 4.32e-02 278 2 1 0.500 0.004 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 Q68CQ7 146 4.35e-02 280 2 1 0.500 0.004 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 Q68CQ7 146 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 Q68CQ7 146 4.38e-02 2664 2 2 1.000 0.001 TF:M01034_1 tf 1 Factor: Ebox; motif: NCACSTGNCN; match class: 1 1 Q68CQ7,Q96MM7 146 4.53e-02 2710 2 2 1.000 0.001 TF:M02019_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q68CQ7,Q96MM7 146 4.53e-02 2710 2 2 1.000 0.001 TF:M03794_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q68CQ7,Q96MM7 146 4.55e-02 2715 2 2 1.000 0.001 TF:M01036_0 tf 1 Factor: COUPTF; motif: NNNNNTGACCYTTGNMCNYNGMN; match class: 0 1 Q68CQ7,Q96MM7 146 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 Q96MM7 146 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q68CQ7 146 4.78e-02 308 2 1 0.500 0.003 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 Q96MM7 146 4.93e-02 418 2 2 1.000 0.005 MI:hsa-miR-617 mi 1 MI:hsa-miR-617 1 Q68CQ7,Q96MM7 146 5.00e-02 12 2 1 0.500 0.083 GO:0034483 MF 1 heparan sulfate sulfotransferase activity 1 Q96MM7 146 5.00e-02 421 2 2 1.000 0.005 MI:hsa-miR-30c-1* mi 1 MI:hsa-miR-30c-1* 1 Q68CQ7,Q96MM7 146 5.00e-02 100 2 1 0.500 0.010 REAC:1630316 rea 1 Glycosaminoglycan metabolism 1 Q96MM7 146 5.00e-02 22 2 1 0.500 0.045 KEGG:00534 keg 1 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 Q96MM7 147 1.26e-03 8 2 1 0.500 0.125 TF:M05629_1 tf 1 Factor: ZNF44; motif: KGATSGRGCCSC; match class: 1 1 Q8NHY2 147 3.47e-03 750 2 2 1.000 0.003 TF:M03923_1 tf 1 Factor: SP8; motif: RCCACGCCCMCY; match class: 1 1 Q8NHY2,P15036 147 5.02e-03 32 2 1 0.500 0.031 TF:M06613_0 tf 1 Factor: ZNF514; motif: NGTTGATTMAGM; match class: 0 1 Q8NHY2 147 6.75e-03 43 2 1 0.500 0.023 TF:M05847_1 tf 1 Factor: ZNF837; motif: NCCWMAWAAARM; match class: 1 1 P15036 147 9.00e-03 52 2 1 0.500 0.019 GO:0032436 BP 1 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1 Q8NHY2 147 9.34e-03 54 2 1 0.500 0.019 GO:0001078 MF 1 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 1 P15036 147 9.69e-03 56 2 1 0.500 0.018 GO:1901800 BP 1 positive regulation of proteasomal protein catabolic process 1 Q8NHY2 147 1.00e-02 1 2 1 0.500 1.000 CORUM:2790 cor 1 ETS2-ETS1 complex 1 P15036 147 1.10e-02 30 2 1 0.500 0.033 REAC:2559585 rea 1 Oncogene Induced Senescence 1 P15036 147 1.31e-02 76 2 1 0.500 0.013 GO:0032434 BP 1 regulation of proteasomal ubiquitin-dependent protein catabolic process 1 Q8NHY2 147 1.35e-02 86 2 1 0.500 0.012 TF:M06025_0 tf 1 Factor: ZNF195; motif: NGWGKAAGCTGC; match class: 0 1 P15036 147 1.37e-02 79 2 1 0.500 0.013 GO:0010212 BP 1 response to ionizing radiation 1 Q8NHY2 147 1.37e-02 79 2 1 0.500 0.013 GO:0001227 MF 1 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 1 P15036 147 1.37e-02 1492 2 2 1.000 0.001 TF:M01002_0 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 0 1 Q8NHY2,P15036 147 1.39e-02 1499 2 2 1.000 0.001 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 Q8NHY2,P15036 147 1.49e-02 1553 2 2 1.000 0.001 TF:M00801_1 tf 1 Factor: CREB; motif: CGTCAN; match class: 1 1 Q8NHY2,P15036 147 1.66e-02 96 2 1 0.500 0.010 GO:0061136 BP 1 regulation of proteasomal protein catabolic process 1 Q8NHY2 147 1.74e-02 1681 2 2 1.000 0.001 TF:M01652_0 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 0 1 Q8NHY2,P15036 147 1.86e-02 51 2 1 0.500 0.020 REAC:349425 rea 1 Autodegradation of the E3 ubiquitin ligase COP1 1 Q8NHY2 147 1.88e-02 120 2 1 0.500 0.008 TF:M05297_0 tf 1 Factor: Sox-1; motif: TRAATATTWAA; match class: 0 1 Q8NHY2 147 1.97e-02 54 2 1 0.500 0.019 REAC:69541 rea 1 Stabilization of p53 1 Q8NHY2 147 2.00e-02 2 2 1 0.500 0.500 CORUM:2789 cor 1 ETS2-ERG complex 1 P15036 147 2.01e-02 1635 2 2 1.000 0.001 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q8NHY2,P15036 147 2.02e-02 117 2 1 0.500 0.009 GO:0061630 MF 1 ubiquitin protein ligase activity 1 Q8NHY2 147 2.03e-02 1644 2 2 1.000 0.001 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q8NHY2,P15036 147 2.09e-02 121 2 1 0.500 0.008 GO:0061659 MF 1 ubiquitin-like protein ligase activity 1 Q8NHY2 147 2.29e-02 1745 2 2 1.000 0.001 GO:0009893 BP 1 positive regulation of metabolic process 1 Q8NHY2,P15036 147 2.29e-02 63 2 1 0.500 0.016 REAC:69563 rea 1 p53-Dependent G1 DNA Damage Response 1 Q8NHY2 147 2.29e-02 63 2 1 0.500 0.016 REAC:69580 rea 1 p53-Dependent G1/S DNA damage checkpoint 1 Q8NHY2 147 2.36e-02 137 2 1 0.500 0.007 GO:0000982 MF 1 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 1 P15036 147 2.37e-02 65 2 1 0.500 0.015 REAC:69615 rea 1 G1/S DNA Damage Checkpoints 1 Q8NHY2 147 2.38e-02 138 2 1 0.500 0.007 GO:1903052 BP 1 positive regulation of proteolysis involved in cellular protein catabolic process 1 Q8NHY2 147 2.46e-02 143 2 1 0.500 0.007 GO:0000978 MF 1 RNA polymerase II core promoter proximal region sequence-specific DNA binding 1 P15036 147 2.48e-02 2006 2 2 1.000 0.001 TF:M00360_1 tf 1 Factor: Pax-3; motif: TCGTCACRCTTHM; match class: 1 1 Q8NHY2,P15036 147 2.53e-02 147 2 1 0.500 0.007 GO:1903364 BP 1 positive regulation of cellular protein catabolic process 1 Q8NHY2 147 2.62e-02 152 2 1 0.500 0.007 GO:0001501 BP 1 skeletal system development 1 P15036 147 2.62e-02 152 2 1 0.500 0.007 GO:0000987 MF 1 core promoter proximal region sequence-specific DNA binding 1 P15036 147 2.64e-02 153 2 1 0.500 0.007 GO:0001159 MF 1 core promoter proximal region DNA binding 1 P15036 147 2.75e-02 176 2 1 0.500 0.006 TF:M03869_1 tf 1 Factor: Fra-1; motif: TGACTCAN; match class: 1 1 P15036 147 2.75e-02 176 2 1 0.500 0.006 TF:M03538_1 tf 1 Factor: AP-1; motif: TGACTCAN; match class: 1 1 P15036 147 2.75e-02 176 2 1 0.500 0.006 TF:M03552_1 tf 1 Factor: JunD; motif: TGACTCAN; match class: 1 1 P15036 147 2.81e-02 180 2 1 0.500 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 P15036 147 2.84e-02 2144 2 2 1.000 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 Q8NHY2,P15036 147 3.00e-02 3 2 1 0.500 0.333 CORUM:2695 cor 1 ETS2-FOS-JUN complex 1 P15036 147 3.00e-02 3 2 1 0.500 0.333 CORUM:5293 cor 1 ETS2-SMARCA4-INI1 complex 1 P15036 147 3.05e-02 177 2 1 0.500 0.006 GO:1903050 BP 1 regulation of proteolysis involved in cellular protein catabolic process 1 Q8NHY2 147 3.16e-02 2264 2 2 1.000 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q8NHY2,P15036 147 3.17e-02 2267 2 2 1.000 0.001 TF:M07390_1 tf 1 Factor: Nfe2l1; motif: TGYNNAGTCATT; match class: 1 1 Q8NHY2,P15036 147 3.27e-02 210 2 1 0.500 0.005 TF:M06245_0 tf 1 Factor: ZNF763; motif: NGAATAAGCCNT; match class: 0 1 P15036 147 3.27e-02 210 2 1 0.500 0.005 TF:M01117_1 tf 1 Factor: OTX; motif: GATTANNT; match class: 1 1 Q8NHY2 147 3.28e-02 191 2 1 0.500 0.005 GO:1903362 BP 1 regulation of cellular protein catabolic process 1 Q8NHY2 147 3.28e-02 191 2 1 0.500 0.005 GO:0045732 BP 1 positive regulation of protein catabolic process 1 Q8NHY2 147 3.30e-02 212 2 1 0.500 0.005 TF:M05770_0 tf 1 Factor: ZNFpT1; motif: GTWTTTTCGA; match class: 0 1 Q8NHY2 147 3.44e-02 200 2 1 0.500 0.005 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 Q8NHY2 147 3.60e-02 231 2 1 0.500 0.004 TF:M05479_0 tf 1 Factor: znf580; motif: NGGGCGGTGTS; match class: 0 1 Q8NHY2 147 3.63e-02 233 2 1 0.500 0.004 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 P15036 147 3.66e-02 2436 2 2 1.000 0.001 TF:M01001_0 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 0 1 Q8NHY2,P15036 147 3.92e-02 252 2 1 0.500 0.004 TF:M03883_1 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 1 1 Q8NHY2 147 4.00e-02 233 2 1 0.500 0.004 GO:0009314 BP 1 response to radiation 1 Q8NHY2 147 4.07e-02 237 2 1 0.500 0.004 GO:0009896 BP 1 positive regulation of catabolic process 1 Q8NHY2 147 4.07e-02 262 2 1 0.500 0.004 TF:M06887_1 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 1 1 Q8NHY2 147 4.11e-02 264 2 1 0.500 0.004 TF:M01217_1 tf 1 Factor: NUR77; motif: NTGACCTTBN; match class: 1 1 Q8NHY2 147 4.24e-02 247 2 1 0.500 0.004 GO:0001012 MF 1 RNA polymerase II regulatory region DNA binding 1 P15036 147 4.24e-02 247 2 1 0.500 0.004 GO:0000977 MF 1 RNA polymerase II regulatory region sequence-specific DNA binding 1 P15036 147 4.24e-02 2622 2 2 1.000 0.001 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 Q8NHY2,P15036 147 4.26e-02 274 2 1 0.500 0.004 TF:M04313_1 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 1 1 Q8NHY2 147 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-454* mi 1 MI:hsa-miR-454* 1 Q8NHY2 147 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 Q8NHY2 147 4.39e-02 256 2 1 0.500 0.004 GO:0045862 BP 1 positive regulation of proteolysis 1 Q8NHY2 147 4.54e-02 2712 2 2 1.000 0.001 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 Q8NHY2,P15036 147 4.58e-02 267 2 1 0.500 0.004 GO:0042176 BP 1 regulation of protein catabolic process 1 Q8NHY2 147 4.66e-02 272 2 1 0.500 0.004 GO:0031329 BP 1 regulation of cellular catabolic process 1 Q8NHY2 147 4.81e-02 2529 2 2 1.000 0.001 GO:0005654 CC 1 nucleoplasm 1 Q8NHY2,P15036 147 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 Q8NHY2 147 5.00e-02 26 2 1 0.500 0.038 KEGG:04320 keg 1 Dorso-ventral axis formation 1 P15036 147 5.00e-02 138 2 1 0.500 0.007 REAC:2559583 rea 1 Cellular Senescence 1 P15036 147 5.00e-02 5 2 1 0.500 0.200 CORUM:1214 cor 1 Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) 1 Q8NHY2 148 6.65e-12 3 3 3 1.000 1.000 GO:0006046 BP 1 N-acetylglucosamine catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.33e-10 6 3 3 1.000 0.500 GO:0019262 BP 1 N-acetylneuraminate catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 3.72e-10 8 3 3 1.000 0.375 GO:0006054 BP 1 N-acetylneuraminate metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 5.59e-10 9 3 3 1.000 0.333 GO:1901072 BP 1 glucosamine-containing compound catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.10e-09 11 3 3 1.000 0.273 GO:0006044 BP 1 N-acetylglucosamine metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.10e-09 11 3 3 1.000 0.273 GO:0006048 BP 1 UDP-N-acetylglucosamine biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.46e-09 12 3 3 1.000 0.250 GO:0046349 BP 1 amino sugar biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.46e-09 12 3 3 1.000 0.250 GO:0046348 BP 1 amino sugar catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.46e-09 12 3 3 1.000 0.250 GO:0006047 BP 1 UDP-N-acetylglucosamine metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 5.43e-09 18 3 3 1.000 0.167 GO:1901071 BP 1 glucosamine-containing compound metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 6.44e-09 19 3 3 1.000 0.158 GO:0009226 BP 1 nucleotide-sugar biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.53e-08 25 3 3 1.000 0.120 GO:0009225 BP 1 nucleotide-sugar metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.70e-08 30 3 3 1.000 0.100 GO:0006040 BP 1 amino sugar metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 7.67e-08 2 3 2 0.667 1.000 GO:0004342 MF 1 glucosamine-6-phosphate deaminase activity 1 P46926,Q8TDQ7 148 2.32e-06 129 3 3 1.000 0.023 GO:1901136 BP 1 carbohydrate derivative catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 3.45e-06 10 3 2 0.667 0.200 GO:0016861 MF 1 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1 P46926,Q8TDQ7 148 5.64e-06 173 3 3 1.000 0.017 GO:0016054 BP 1 organic acid catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 5.64e-06 173 3 3 1.000 0.017 GO:0046395 BP 1 carboxylic acid catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.63e-05 246 3 3 1.000 0.012 GO:0044282 BP 1 small molecule catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.30e-05 25 3 2 0.667 0.080 GO:0019239 MF 1 deaminase activity 1 P46926,Q8TDQ7 148 6.59e-05 42 3 2 0.667 0.048 GO:0016860 MF 1 intramolecular oxidoreductase activity 1 P46926,Q8TDQ7 148 1.11e-04 466 3 3 1.000 0.006 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 2.06e-04 572 3 3 1.000 0.005 GO:0044712 BP 1 single-organism catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 3.03e-04 650 3 3 1.000 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 4.28e-04 729 3 3 1.000 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 4.42e-04 1 3 1 0.333 1.000 GO:0008448 MF 1 N-acetylglucosamine-6-phosphate deacetylase activity 1 Q9Y303 148 4.42e-04 1 3 1 0.333 1.000 GO:0006043 BP 1 glucosamine catabolic process 1 P46926 148 4.45e-04 739 3 3 1.000 0.004 GO:0006082 BP 1 organic acid metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 4.57e-04 110 3 2 0.667 0.018 GO:0006006 BP 1 glucose metabolic process 1 P46926,Q8TDQ7 148 5.61e-04 798 3 3 1.000 0.004 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 6.00e-04 126 3 2 0.667 0.016 GO:0016853 MF 1 isomerase activity 1 P46926,Q8TDQ7 148 7.09e-04 137 3 2 0.667 0.015 GO:0019318 BP 1 hexose metabolic process 1 P46926,Q8TDQ7 148 7.79e-04 77 3 2 0.667 0.026 REAC:70326 rea 1 Glucose metabolism 1 P46926,Q8TDQ7 148 8.84e-04 2 3 1 0.333 0.500 GO:0006041 BP 1 glucosamine metabolic process 1 P46926 148 1.09e-03 170 3 2 0.667 0.012 GO:0005996 BP 1 monosaccharide metabolic process 1 P46926,Q8TDQ7 148 1.64e-03 1141 3 3 1.000 0.003 GO:0044248 BP 1 cellular catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.37e-03 1290 3 3 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.62e-03 1333 3 3 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.79e-03 1362 3 3 1.000 0.002 GO:0009056 BP 1 catabolic process 1 P46926,Q9Y303,Q8TDQ7 148 2.88e-03 277 3 2 0.667 0.007 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 P46926,Q8TDQ7 148 3.94e-03 324 3 2 0.667 0.006 GO:0005975 BP 1 carbohydrate metabolic process 1 P46926,Q8TDQ7 148 7.74e-03 8 3 1 0.333 0.125 REAC:446210 rea 1 Synthesis of UDP-N-acetyl-glucosamine 1 Q9Y303 148 7.87e-03 1923 3 3 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 7.90e-03 246 3 2 0.667 0.008 REAC:71387 rea 1 Metabolism of carbohydrates 1 P46926,Q8TDQ7 148 9.44e-03 10 3 1 0.333 0.100 TF:M06123_0 tf 1 Factor: ZNF324; motif: KGGTWAAGGGGA; match class: 0 1 Q9Y303 148 9.44e-03 10 3 1 0.333 0.100 TF:M05754_0 tf 1 Factor: ZNF324B; motif: KGGTWAAGGGGA; match class: 0 1 Q9Y303 148 1.02e-02 1737 3 3 1.000 0.002 TF:M01011_1 tf 1 Factor: HNF1; motif: NNNNGNTAAWNATTAACYNNN; match class: 1 1 P46926,Q9Y303,Q8TDQ7 148 1.29e-02 2267 3 3 1.000 0.001 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.36e-02 2305 3 3 1.000 0.001 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.36e-02 2310 3 3 1.000 0.001 GO:0018130 BP 1 heterocycle biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.48e-02 2374 3 3 1.000 0.001 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 1.63e-02 37 3 1 0.333 0.027 GO:0007338 BP 1 single fertilization 1 P46926 148 1.79e-02 19 3 1 0.333 0.053 TF:M04453_0 tf 1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 0 1 P46926 148 1.86e-02 2560 3 3 1.000 0.001 GO:0044710 BP 1 single-organism metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 1.91e-02 2144 3 3 1.000 0.001 TF:M00924_1 tf 1 Factor: AP-1; motif: TGACTCANNSKN; match class: 1 1 P46926,Q9Y303,Q8TDQ7 148 1.98e-02 45 3 1 0.333 0.022 GO:0019213 MF 1 deacetylase activity 1 Q9Y303 148 1.98e-02 45 3 1 0.333 0.022 GO:0009566 BP 1 fertilization 1 P46926 148 2.20e-02 2707 3 3 1.000 0.001 GO:0005829 CC 1 cytosol 1 P46926,Q9Y303,Q8TDQ7 148 2.20e-02 2707 3 3 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 2.36e-02 25 3 1 0.333 0.040 TF:M05428_0 tf 1 Factor: RP58; motif: NGGGGCAAGSCM; match class: 0 1 Q9Y303 148 2.73e-02 62 3 1 0.333 0.016 GO:0016811 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1 Q9Y303 148 3.03e-02 651 3 2 0.667 0.003 TF:M01123_0 tf 1 Factor: Nanog; motif: GGGNCCATTKCC; match class: 0 1 P46926,Q8TDQ7 148 3.42e-02 2601 3 3 1.000 0.001 TF:M02280_1 tf 1 Factor: AP1; motif: TGACTCA; match class: 1 1 P46926,Q9Y303,Q8TDQ7 148 3.64e-02 2657 3 3 1.000 0.001 TF:M00132_0 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 0 1 P46926,Q9Y303,Q8TDQ7 148 3.77e-02 40 3 1 0.333 0.025 TF:M06495_0 tf 1 Factor: ZNF433; motif: TGKAACAGACCK; match class: 0 1 P46926 148 4.34e-02 99 3 1 0.333 0.010 GO:0016810 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Q9Y303 148 4.41e-02 788 3 2 0.667 0.003 TF:M07233_0 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 0 1 P46926,Q9Y303 148 4.52e-02 3443 3 3 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 4.74e-02 3499 3 3 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 P46926,Q9Y303,Q8TDQ7 148 4.80e-02 51 3 1 0.333 0.020 TF:M04059_1 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 1 1 Q8TDQ7 148 4.80e-02 51 3 1 0.333 0.020 TF:M04059_0 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 0 1 Q8TDQ7 148 4.97e-02 3554 3 3 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 5.00e-02 840 3 2 0.667 0.002 TF:M00172_1 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 1 1 P46926,Q8TDQ7 148 5.00e-02 3561 3 3 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P46926,Q9Y303,Q8TDQ7 148 5.00e-02 342 3 2 0.667 0.006 HPA:039020_03 hpa 1 soft tissue 1; chondrocytes[Uncertain,High] 1 P46926,Q8TDQ7 148 5.00e-02 46 3 3 1.000 0.065 KEGG:00520 keg 1 Amino sugar and nucleotide sugar metabolism 1 P46926,Q9Y303,Q8TDQ7 149 6.60e-12 3 3 3 1.000 1.000 GO:0016309 MF 1 1-phosphatidylinositol-5-phosphate 4-kinase activity 1 P48426,Q8TBX8,P78356 149 3.70e-10 8 3 3 1.000 0.375 GO:2000786 BP 1 positive regulation of autophagosome assembly 1 P48426,Q8TBX8,P78356 149 7.93e-10 10 3 3 1.000 0.300 GO:0044090 BP 1 positive regulation of vacuole organization 1 P48426,Q8TBX8,P78356 149 2.40e-09 14 3 3 1.000 0.214 GO:0016307 MF 1 phosphatidylinositol phosphate kinase activity 1 P48426,Q8TBX8,P78356 149 2.68e-08 30 3 3 1.000 0.100 GO:0016239 BP 1 positive regulation of macroautophagy 1 P48426,Q8TBX8,P78356 149 2.68e-08 30 3 3 1.000 0.100 GO:2000785 BP 1 regulation of autophagosome assembly 1 P48426,Q8TBX8,P78356 149 5.13e-08 37 3 3 1.000 0.081 GO:0044088 BP 1 regulation of vacuole organization 1 P48426,Q8TBX8,P78356 149 5.57e-08 38 3 3 1.000 0.079 GO:1902117 BP 1 positive regulation of organelle assembly 1 P48426,Q8TBX8,P78356 149 1.29e-07 50 3 3 1.000 0.060 GO:0005776 CC 1 autophagosome 1 P48426,Q8TBX8,P78356 149 2.26e-07 60 3 3 1.000 0.050 GO:0010508 BP 1 positive regulation of autophagy 1 P48426,Q8TBX8,P78356 149 2.41e-07 30 3 3 1.000 0.100 REAC:6804758 rea 1 Regulation of TP53 Activity through Acetylation 1 P48426,Q8TBX8,P78356 149 3.46e-07 69 3 3 1.000 0.043 GO:0000045 BP 1 autophagosome assembly 1 P48426,Q8TBX8,P78356 149 3.62e-07 70 3 3 1.000 0.043 GO:1905037 BP 1 autophagosome organization 1 P48426,Q8TBX8,P78356 149 5.43e-07 80 3 3 1.000 0.037 GO:0006661 BP 1 phosphatidylinositol biosynthetic process 1 P48426,Q8TBX8,P78356 149 5.64e-07 81 3 3 1.000 0.037 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 P48426,Q8TBX8,P78356 149 7.62e-07 5 3 2 0.667 0.400 GO:0052811 MF 1 1-phosphatidylinositol-3-phosphate 4-kinase activity 1 P48426,P78356 149 7.85e-07 44 3 3 1.000 0.068 REAC:1660499 rea 1 Synthesis of PIPs at the plasma membrane 1 P48426,Q8TBX8,P78356 149 8.85e-07 94 3 3 1.000 0.032 GO:0014065 BP 1 phosphatidylinositol 3-kinase signaling 1 P48426,Q8TBX8,P78356 149 1.04e-06 99 3 3 1.000 0.030 GO:0016241 BP 1 regulation of macroautophagy 1 P48426,Q8TBX8,P78356 149 1.13e-06 102 3 3 1.000 0.029 GO:0046488 BP 1 phosphatidylinositol metabolic process 1 P48426,Q8TBX8,P78356 149 1.14e-06 6 3 2 0.667 0.333 GO:0016308 MF 1 1-phosphatidylinositol-4-phosphate 5-kinase activity 1 P48426,P78356 149 1.76e-06 118 3 3 1.000 0.025 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 P48426,Q8TBX8,P78356 149 1.81e-06 119 3 3 1.000 0.025 GO:0048017 BP 1 inositol lipid-mediated signaling 1 P48426,Q8TBX8,P78356 149 2.36e-06 130 3 3 1.000 0.023 GO:0007033 BP 1 vacuole organization 1 P48426,Q8TBX8,P78356 149 2.36e-06 130 3 3 1.000 0.023 GO:1902115 BP 1 regulation of organelle assembly 1 P48426,Q8TBX8,P78356 149 2.47e-06 64 3 3 1.000 0.047 REAC:6811558 rea 1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1 P48426,Q8TBX8,P78356 149 2.97e-06 68 3 3 1.000 0.044 REAC:1483255 rea 1 PI Metabolism 1 P48426,Q8TBX8,P78356 149 3.22e-06 144 3 3 1.000 0.021 GO:0046474 BP 1 glycerophospholipid biosynthetic process 1 P48426,Q8TBX8,P78356 149 3.39e-06 71 3 3 1.000 0.042 REAC:199418 rea 1 Negative regulation of the PI3K/AKT network 1 P48426,Q8TBX8,P78356 149 4.26e-06 158 3 3 1.000 0.019 GO:0008654 BP 1 phospholipid biosynthetic process 1 P48426,Q8TBX8,P78356 149 4.68e-06 163 3 3 1.000 0.018 GO:0045017 BP 1 glycerolipid biosynthetic process 1 P48426,Q8TBX8,P78356 149 7.55e-06 191 3 3 1.000 0.016 GO:0006650 BP 1 glycerophospholipid metabolic process 1 P48426,Q8TBX8,P78356 149 9.07e-06 203 3 3 1.000 0.015 GO:0016236 BP 1 macroautophagy 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:5654720 rea 1 PI-3K cascade:FGFR4 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:5654689 rea 1 PI-3K cascade:FGFR1 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:5654695 rea 1 PI-3K cascade:FGFR2 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:1257604 rea 1 PIP3 activates AKT signaling 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:5654710 rea 1 PI-3K cascade:FGFR3 1 P48426,Q8TBX8,P78356 149 9.58e-06 100 3 3 1.000 0.030 REAC:1250342 rea 1 PI3K events in ERBB4 signaling 1 P48426,Q8TBX8,P78356 149 9.62e-06 207 3 3 1.000 0.014 GO:0010506 BP 1 regulation of autophagy 1 P48426,Q8TBX8,P78356 149 1.02e-05 102 3 3 1.000 0.029 REAC:198203 rea 1 PI3K/AKT activation 1 P48426,Q8TBX8,P78356 149 1.05e-05 103 3 3 1.000 0.029 REAC:180292 rea 1 GAB1 signalosome 1 P48426,Q8TBX8,P78356 149 1.11e-05 105 3 3 1.000 0.029 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 P48426,Q8TBX8,P78356 149 1.48e-05 239 3 3 1.000 0.013 GO:0046486 BP 1 glycerolipid metabolic process 1 P48426,Q8TBX8,P78356 149 1.50e-05 240 3 3 1.000 0.013 GO:0006644 BP 1 phospholipid metabolic process 1 P48426,Q8TBX8,P78356 149 2.00e-05 264 3 3 1.000 0.011 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 P48426,Q8TBX8,P78356 149 3.27e-05 150 3 3 1.000 0.020 REAC:5633007 rea 1 Regulation of TP53 Activity 1 P48426,Q8TBX8,P78356 149 4.06e-05 334 3 3 1.000 0.009 GO:0090407 BP 1 organophosphate biosynthetic process 1 P48426,Q8TBX8,P78356 149 4.29e-05 340 3 3 1.000 0.009 GO:0006914 BP 1 autophagy 1 P48426,Q8TBX8,P78356 149 4.36e-05 165 3 3 1.000 0.018 REAC:1483257 rea 1 Phospholipid metabolism 1 P48426,Q8TBX8,P78356 149 4.60e-05 168 3 3 1.000 0.018 REAC:1168372 rea 1 Downstream signaling events of B Cell Receptor (BCR) 1 P48426,Q8TBX8,P78356 149 5.09e-05 360 3 3 1.000 0.008 GO:0010638 BP 1 positive regulation of organelle organization 1 P48426,Q8TBX8,P78356 149 5.40e-05 367 3 3 1.000 0.008 GO:0008610 BP 1 lipid biosynthetic process 1 P48426,Q8TBX8,P78356 149 6.36e-05 187 3 3 1.000 0.016 REAC:983705 rea 1 Signaling by the B Cell Receptor (BCR) 1 P48426,Q8TBX8,P78356 149 6.68e-05 394 3 3 1.000 0.008 GO:0005773 CC 1 vacuole 1 P48426,Q8TBX8,P78356 149 9.63e-05 445 3 3 1.000 0.007 GO:0070925 BP 1 organelle assembly 1 P48426,Q8TBX8,P78356 149 1.40e-04 504 3 3 1.000 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 P48426,Q8TBX8,P78356 149 1.94e-04 271 3 3 1.000 0.011 REAC:1433557 rea 1 Signaling by SCF-KIT 1 P48426,Q8TBX8,P78356 149 1.97e-04 272 3 3 1.000 0.011 REAC:1236394 rea 1 Signaling by ERBB4 1 P48426,Q8TBX8,P78356 149 2.11e-04 578 3 3 1.000 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P48426,Q8TBX8,P78356 149 2.15e-04 280 3 3 1.000 0.011 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 P48426,Q8TBX8,P78356 149 2.15e-04 280 3 3 1.000 0.011 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 P48426,Q8TBX8,P78356 149 2.15e-04 280 3 3 1.000 0.011 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 P48426,Q8TBX8,P78356 149 2.17e-04 281 3 3 1.000 0.011 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 P48426,Q8TBX8,P78356 149 2.22e-04 283 3 3 1.000 0.011 REAC:5654741 rea 1 Signaling by FGFR3 1 P48426,Q8TBX8,P78356 149 2.22e-04 283 3 3 1.000 0.011 REAC:5654743 rea 1 Signaling by FGFR4 1 P48426,Q8TBX8,P78356 149 2.26e-04 285 3 3 1.000 0.011 REAC:5654736 rea 1 Signaling by FGFR1 1 P48426,Q8TBX8,P78356 149 2.38e-04 290 3 3 1.000 0.010 REAC:2424491 rea 1 DAP12 signaling 1 P48426,Q8TBX8,P78356 149 2.43e-04 292 3 3 1.000 0.010 REAC:186763 rea 1 Downstream signal transduction 1 P48426,Q8TBX8,P78356 149 2.48e-04 294 3 3 1.000 0.010 REAC:2172127 rea 1 DAP12 interactions 1 P48426,Q8TBX8,P78356 149 2.74e-04 630 3 3 1.000 0.005 GO:0016301 MF 1 kinase activity 1 P48426,Q8TBX8,P78356 149 2.75e-04 304 3 3 1.000 0.010 REAC:177929 rea 1 Signaling by EGFR 1 P48426,Q8TBX8,P78356 149 2.78e-04 305 3 3 1.000 0.010 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 P48426,Q8TBX8,P78356 149 2.78e-04 633 3 3 1.000 0.005 GO:0044255 BP 1 cellular lipid metabolic process 1 P48426,Q8TBX8,P78356 149 2.89e-04 309 3 3 1.000 0.010 REAC:5654738 rea 1 Signaling by FGFR2 1 P48426,Q8TBX8,P78356 149 2.94e-04 311 3 3 1.000 0.010 REAC:190236 rea 1 Signaling by FGFR 1 P48426,Q8TBX8,P78356 149 2.97e-04 312 3 3 1.000 0.010 REAC:186797 rea 1 Signaling by PDGF 1 P48426,Q8TBX8,P78356 149 3.27e-04 322 3 3 1.000 0.009 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 P48426,Q8TBX8,P78356 149 3.36e-04 674 3 3 1.000 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 P48426,Q8TBX8,P78356 149 3.55e-04 331 3 3 1.000 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 P48426,Q8TBX8,P78356 149 3.87e-04 707 3 3 1.000 0.004 GO:0033043 BP 1 regulation of organelle organization 1 P48426,Q8TBX8,P78356 149 3.87e-04 707 3 3 1.000 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 P48426,Q8TBX8,P78356 149 4.72e-04 755 3 3 1.000 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P48426,Q8TBX8,P78356 149 4.91e-04 765 3 3 1.000 0.004 GO:0006629 BP 1 lipid metabolic process 1 P48426,Q8TBX8,P78356 149 6.00e-04 394 3 3 1.000 0.008 REAC:166520 rea 1 Signalling by NGF 1 P48426,Q8TBX8,P78356 149 6.76e-04 851 3 3 1.000 0.004 GO:0044711 BP 1 single-organism biosynthetic process 1 P48426,Q8TBX8,P78356 149 1.19e-03 1027 3 3 1.000 0.003 GO:1902531 BP 1 regulation of intracellular signal transduction 1 P48426,Q8TBX8,P78356 149 2.14e-03 7 3 1 0.333 0.143 TF:M06156_1 tf 1 Factor: ZNF75; motif: NCATSCGGCTRC; match class: 1 1 P48426 149 2.19e-03 606 3 3 1.000 0.005 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 P48426,Q8TBX8,P78356 149 2.28e-03 614 3 3 1.000 0.005 REAC:1280218 rea 1 Adaptive Immune System 1 P48426,Q8TBX8,P78356 149 2.43e-03 628 3 3 1.000 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 P48426,Q8TBX8,P78356 149 2.61e-03 66 3 3 1.000 0.045 KEGG:00562 keg 1 Inositol phosphate metabolism 1 P48426,Q8TBX8,P78356 149 3.27e-03 1438 3 3 1.000 0.002 GO:0051128 BP 1 regulation of cellular component organization 1 P48426,Q8TBX8,P78356 149 3.96e-03 1533 3 3 1.000 0.002 GO:0035556 BP 1 intracellular signal transduction 1 P48426,Q8TBX8,P78356 149 4.28e-03 1573 3 3 1.000 0.002 GO:0009966 BP 1 regulation of signal transduction 1 P48426,Q8TBX8,P78356 149 5.31e-03 1691 3 3 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 P48426,Q8TBX8,P78356 149 5.46e-03 1706 3 3 1.000 0.002 GO:0022607 BP 1 cellular component assembly 1 P48426,Q8TBX8,P78356 149 5.50e-03 18 3 1 0.333 0.056 TF:M06460_0 tf 1 Factor: ZNF808; motif: NGGGGAWGTAGA; match class: 0 1 P48426 149 5.54e-03 1715 3 3 1.000 0.002 GO:0016740 MF 1 transferase activity 1 P48426,Q8TBX8,P78356 149 5.67e-03 1728 3 3 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 P48426,Q8TBX8,P78356 149 6.47e-03 89 3 3 1.000 0.034 KEGG:04070 keg 1 Phosphatidylinositol signaling system 1 P48426,Q8TBX8,P78356 149 6.97e-03 1851 3 3 1.000 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P48426,Q8TBX8,P78356 149 7.02e-03 23 3 1 0.333 0.043 TF:M04179_0 tf 1 Factor: MLX; motif: RTCACGTGAT; match class: 0 1 Q8TBX8 149 7.02e-03 23 3 1 0.333 0.043 TF:M04179_1 tf 1 Factor: MLX; motif: RTCACGTGAT; match class: 1 1 Q8TBX8 149 7.33e-03 24 3 1 0.333 0.042 TF:M04178_1 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 1 1 Q8TBX8 149 7.82e-03 1923 3 3 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 P48426,Q8TBX8,P78356 149 7.93e-03 1932 3 3 1.000 0.002 GO:0044085 BP 1 cellular component biogenesis 1 P48426,Q8TBX8,P78356 149 8.13e-03 938 3 3 1.000 0.003 REAC:168249 rea 1 Innate Immune System 1 P48426,Q8TBX8,P78356 149 8.55e-03 28 3 1 0.333 0.036 TF:M00220_1 tf 1 Factor: SREBP-1; motif: NATCACGTGAY; match class: 1 1 Q8TBX8 149 9.37e-03 2461 3 3 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 P48426,Q8TBX8,P78356 149 9.73e-03 2492 3 3 1.000 0.001 TF:M05347_0 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 0 1 P48426,Q8TBX8,P78356 149 1.02e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 P48426,Q8TBX8,P78356 149 1.27e-02 2262 3 3 1.000 0.001 GO:0006996 BP 1 organelle organization 1 P48426,Q8TBX8,P78356 149 1.61e-02 53 3 1 0.333 0.019 TF:M05325_0 tf 1 Factor: Tbx3; motif: AGGTGTGAAAT; match class: 0 1 P48426 149 1.61e-02 53 3 1 0.333 0.019 TF:M05365_0 tf 1 Factor: TBX2; motif: AGGTGTGAAAT; match class: 0 1 P48426 149 1.84e-02 896 3 2 0.667 0.002 TF:M02009_0 tf 1 Factor: GCNF; motif: NRAGGTCAAN; match class: 0 1 P48426,Q8TBX8 149 1.84e-02 2560 3 3 1.000 0.001 GO:0044710 BP 1 single-organism metabolic process 1 P48426,Q8TBX8,P78356 149 1.86e-02 3090 3 3 1.000 0.001 TF:M03914_0 tf 1 Factor: KLF16; motif: GMCACGCCCCC; match class: 0 1 P48426,Q8TBX8,P78356 149 2.18e-02 2707 3 3 1.000 0.001 GO:0005829 CC 1 cytosol 1 P48426,Q8TBX8,P78356 149 2.19e-02 72 3 1 0.333 0.014 TF:M04183_0 tf 1 Factor: NEUROG2; motif: RACATATGTC; match class: 0 1 Q8TBX8 149 2.31e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 P48426,Q8TBX8,P78356 149 2.39e-02 3364 3 3 1.000 0.001 TF:M01875_0 tf 1 Factor: ER-beta; motif: GTCANASTGRCCYNR; match class: 0 1 P48426,Q8TBX8,P78356 149 2.44e-02 1036 3 2 0.667 0.002 TF:M07253_0 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 0 1 P48426,Q8TBX8 149 2.44e-02 1036 3 2 0.667 0.002 TF:M01132_0 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 0 1 P48426,Q8TBX8 149 2.49e-02 82 3 1 0.333 0.012 TF:M03980_0 tf 1 Factor: ETV2; motif: AACCGGAAATR; match class: 0 1 P48426 149 2.57e-02 3443 3 3 1.000 0.001 TF:M00935_0 tf 1 Factor: NF-AT; motif: NWGGAAANWN; match class: 0 1 P48426,Q8TBX8,P78356 149 2.95e-02 97 3 1 0.333 0.010 TF:M04005_0 tf 1 Factor: TCF7L1; motif: AAAGATCAAAGG; match class: 0 1 Q8TBX8 149 2.95e-02 97 3 1 0.333 0.010 TF:M00068_0 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 0 1 P48426 149 2.95e-02 97 3 1 0.333 0.010 TF:M07420_1 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 1 1 P78356 149 2.98e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 P48426,Q8TBX8,P78356 149 3.05e-02 1457 3 3 1.000 0.002 REAC:168256 rea 1 Immune System 1 P48426,Q8TBX8,P78356 149 3.07e-02 3033 3 3 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 P48426,Q8TBX8,P78356 149 3.15e-02 3685 3 3 1.000 0.001 TF:M03573_0 tf 1 Factor: FKHL5; motif: ATGTTTAT; match class: 0 1 P48426,Q8TBX8,P78356 149 3.18e-02 1188 3 2 0.667 0.002 TF:M01968_1 tf 1 Factor: FOXO1; motif: TGTTKAC; match class: 1 1 P48426,Q8TBX8 149 3.23e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 P48426,Q8TBX8,P78356 149 3.33e-02 121 3 1 0.333 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 P48426 149 3.50e-02 3817 3 3 1.000 0.001 TF:M07345_0 tf 1 Factor: ZNF515; motif: SCTGCTGK; match class: 0 1 P48426,Q8TBX8,P78356 149 3.53e-02 3828 3 3 1.000 0.001 TF:M03821_0 tf 1 Factor: ER-beta; motif: ANNSTGACCYRGNN; match class: 0 1 P48426,Q8TBX8,P78356 149 3.68e-02 3881 3 3 1.000 0.001 TF:M01127_0 tf 1 Factor: islet1; motif: GSNTAATRK; match class: 0 1 P48426,Q8TBX8,P78356 149 3.70e-02 122 3 1 0.333 0.008 TF:M04178_0 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 0 1 Q8TBX8 149 3.82e-02 3262 3 3 1.000 0.001 GO:0007154 BP 1 cell communication 1 P48426,Q8TBX8,P78356 149 3.84e-02 3268 3 3 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 P48426,Q8TBX8,P78356 149 3.84e-02 3938 3 3 1.000 0.001 TF:M00072_0 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 0 1 P48426,Q8TBX8,P78356 149 3.85e-02 1575 3 3 1.000 0.002 REAC:162582 rea 1 Signal Transduction 1 P48426,Q8TBX8,P78356 149 3.86e-02 3274 3 3 1.000 0.001 GO:0023052 BP 1 signaling 1 P48426,Q8TBX8,P78356 149 3.88e-02 128 3 1 0.333 0.008 TF:M06358_0 tf 1 Factor: ZNF787; motif: NTGRTAAGGCYM; match class: 0 1 P48426 149 4.06e-02 1310 3 2 0.667 0.002 HPA:046020_03 hpa 1 tonsil; non-germinal center cells[Uncertain,High] 1 P48426,Q8TBX8 149 4.11e-02 1357 3 2 0.667 0.001 TF:M07391_1 tf 1 Factor: NKX2B; motif: ANNCACTTNA; match class: 1 1 P48426,Q8TBX8 149 4.18e-02 96 3 1 0.333 0.010 GO:0005057 MF 1 signal transducer activity, downstream of receptor 1 P78356 149 4.27e-02 4078 3 3 1.000 0.001 TF:M07277_1 tf 1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 1 P48426,Q8TBX8,P78356 149 4.39e-02 145 3 1 0.333 0.007 TF:M01723_0 tf 1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 0 1 Q8TBX8 149 4.39e-02 4117 3 3 1.000 0.001 TF:M03921_0 tf 1 Factor: SP3; motif: NCCACGCCCMC; match class: 0 1 P48426,Q8TBX8,P78356 149 4.60e-02 152 3 1 0.333 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q8TBX8 149 4.60e-02 152 3 1 0.333 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q8TBX8 149 4.60e-02 152 3 1 0.333 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q8TBX8 149 4.60e-02 152 3 1 0.333 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q8TBX8 149 4.71e-02 3499 3 3 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 P48426,Q8TBX8,P78356 149 5.00e-02 3569 3 3 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 P48426,Q8TBX8,P78356 149 5.00e-02 1718 3 3 1.000 0.002 REAC:1430728 rea 1 Metabolism 1 P48426,Q8TBX8,P78356 149 5.00e-02 1503 3 2 0.667 0.001 TF:M00976_0 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 0 1 Q8TBX8,P78356 149 5.00e-02 175 3 3 1.000 0.017 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 P48426,Q8TBX8,P78356 150 1.13e-25 13 13 9 0.692 0.692 GO:0000346 CC 1 transcription export complex 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.62e-21 8 13 7 0.538 0.875 GO:0046784 BP 1 viral mRNA export from host cell nucleus 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 6.95e-21 63 13 10 0.769 0.159 GO:0006369 BP 1 termination of RNA polymerase II transcription 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.32e-19 83 13 10 0.769 0.120 GO:0031124 BP 1 mRNA 3'-end processing 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 8.40e-19 99 13 10 0.769 0.101 GO:0006353 BP 1 DNA-templated transcription, termination 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 9.33e-19 100 13 10 0.769 0.100 GO:0006406 BP 1 mRNA export from nucleus 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 9.33e-19 100 13 10 0.769 0.100 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.16e-18 6 13 6 0.462 1.000 GO:0000445 CC 1 THO complex part of transcription export complex 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 1.16e-18 6 13 6 0.462 1.000 GO:0000347 CC 1 THO complex 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 1.41e-18 104 13 10 0.769 0.096 GO:0051028 BP 1 mRNA transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 2.29e-18 109 13 10 0.769 0.092 GO:0031123 BP 1 RNA 3'-end processing 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 2.77e-18 111 13 10 0.769 0.090 GO:0006405 BP 1 RNA export from nucleus 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 3.04e-18 112 13 10 0.769 0.089 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 4.01e-18 115 13 10 0.769 0.087 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 9.51e-18 125 13 10 0.769 0.080 GO:0050658 BP 1 RNA transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 9.51e-18 125 13 10 0.769 0.080 GO:0050657 BP 1 nucleic acid transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.22e-17 128 13 10 0.769 0.078 GO:0051236 BP 1 establishment of RNA localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 3.29e-17 7 13 7 0.538 1.000 CORUM:770 cor 1 TREX complex 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 3.55e-17 142 13 10 0.769 0.070 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 7.64e-17 153 13 10 0.769 0.065 GO:0051168 BP 1 nuclear export 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.03e-16 52 13 10 0.769 0.192 REAC:72187 rea 1 mRNA 3'-end processing 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.06e-16 158 13 10 0.769 0.063 GO:0006403 BP 1 RNA localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.87e-16 61 13 10 0.769 0.164 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.87e-16 61 13 10 0.769 0.164 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.89e-15 68 13 10 0.769 0.147 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 2.17e-15 342 13 11 0.846 0.032 GO:0006397 BP 1 mRNA processing 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 5.37e-15 75 13 10 0.769 0.133 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.29e-13 318 13 10 0.769 0.031 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.56e-13 324 13 10 0.769 0.031 GO:0051169 BP 1 nuclear transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 2.33e-13 522 13 11 0.846 0.021 GO:0016071 BP 1 mRNA metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 4.77e-13 65 13 7 0.538 0.108 GO:0075733 BP 1 intracellular transport of virus 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.33e-13 66 13 7 0.538 0.106 GO:1902581 BP 1 multi-organism cellular localization 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.33e-13 66 13 7 0.538 0.106 GO:1902583 BP 1 multi-organism intracellular transport 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.95e-13 67 13 7 0.538 0.104 GO:0046794 BP 1 transport of virus 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 6.60e-13 374 13 10 0.769 0.027 GO:0071705 BP 1 nitrogen compound transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 8.19e-13 70 13 7 0.538 0.100 GO:1902579 BP 1 multi-organism localization 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 8.19e-13 70 13 7 0.538 0.100 GO:0044766 BP 1 multi-organism transport 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 3.09e-12 5 13 5 0.385 1.000 CORUM:774 cor 1 THO complex 1 Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 3.62e-12 140 13 10 0.769 0.071 REAC:73857 rea 1 RNA Polymerase II Transcription 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.29e-11 752 13 11 0.846 0.015 GO:0006396 BP 1 RNA processing 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 5.23e-10 228 13 10 0.769 0.044 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.31e-09 100 13 6 0.462 0.060 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 2.47e-09 3 13 3 0.231 1.000 GO:2000002 BP 1 negative regulation of DNA damage checkpoint 1 Q96FV9,Q13769,Q13838 150 2.62e-09 112 13 6 0.462 0.054 GO:0000781 CC 1 chromosome, telomeric region 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 9.86e-09 4 13 3 0.231 0.750 GO:1901977 BP 1 negative regulation of cell cycle checkpoint 1 Q96FV9,Q13769,Q13838 150 5.58e-08 1177 13 10 0.769 0.008 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 6.03e-08 341 13 7 0.538 0.021 GO:0019058 BP 1 viral life cycle 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 9.05e-08 1237 13 10 0.769 0.008 GO:0046907 BP 1 intracellular transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.12e-07 373 13 7 0.538 0.019 GO:0016032 BP 1 viral process 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.16e-07 375 13 7 0.538 0.019 GO:0044764 BP 1 multi-organism cellular process 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.42e-07 386 13 7 0.538 0.018 GO:0044419 BP 1 interspecies interaction between organisms 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.42e-07 386 13 7 0.538 0.018 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.98e-07 230 13 6 0.462 0.026 GO:0098687 CC 1 chromosomal region 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 2.09e-07 141 13 8 0.615 0.057 CORUM:351 cor 1 Spliceosome 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.41e-07 1865 13 11 0.846 0.006 GO:0006351 BP 1 transcription, DNA-templated 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.51e-07 1872 13 11 0.846 0.006 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.56e-07 1377 13 10 0.769 0.007 GO:0071702 BP 1 organic substance transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 2.77e-07 2529 13 12 0.923 0.005 GO:0005654 CC 1 nucleoplasm 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 2.95e-07 10 13 3 0.231 0.300 GO:2000001 BP 1 regulation of DNA damage checkpoint 1 Q96FV9,Q13769,Q13838 150 2.95e-07 10 13 3 0.231 0.300 GO:0016973 BP 1 poly(A)+ mRNA export from nucleus 1 O75152,Q9BY77,Q8NI27 150 4.56e-07 1980 13 11 0.846 0.006 GO:0032774 BP 1 RNA biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 5.58e-07 1493 13 10 0.769 0.007 GO:0051649 BP 1 establishment of localization in cell 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.21e-06 1618 13 10 0.769 0.006 GO:0033036 BP 1 macromolecule localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.56e-06 2931 13 12 0.923 0.004 GO:0031981 CC 1 nuclear lumen 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 1.92e-06 2267 13 11 0.846 0.005 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.29e-06 2305 13 11 0.846 0.005 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.34e-06 2310 13 11 0.846 0.005 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.65e-06 357 13 6 0.462 0.017 GO:0044454 CC 1 nuclear chromosome part 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 3.13e-06 2374 13 11 0.846 0.005 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 3.75e-06 22 13 3 0.231 0.136 GO:0032786 BP 1 positive regulation of DNA-templated transcription, elongation 1 Q96FV9,Q13769,Q13838 150 3.89e-06 3168 13 12 0.923 0.004 GO:0044428 CC 1 nuclear part 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 4.00e-06 383 13 6 0.462 0.016 GO:0000228 CC 1 nuclear chromosome 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 4.05e-06 1836 13 10 0.769 0.005 GO:0051641 BP 1 cellular localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 4.91e-06 650 13 7 0.538 0.011 GO:0051704 BP 1 multi-organism process 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 5.59e-06 25 13 3 0.231 0.120 GO:1901976 BP 1 regulation of cell cycle checkpoint 1 Q96FV9,Q13769,Q13838 150 6.06e-06 152 13 7 0.538 0.046 KEGG:03013 keg 1 RNA transport 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 8.62e-06 4430 13 13 1.000 0.003 GO:0005634 CC 1 nucleus 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 9.08e-06 2627 13 11 0.846 0.004 GO:0016070 BP 1 RNA metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.24e-05 2707 13 11 0.846 0.004 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.38e-05 115 13 4 0.308 0.035 GO:0006354 BP 1 DNA-templated transcription, elongation 1 Q96FV9,Q13769,Q6I9Y2,Q13838 150 1.38e-05 1118 13 8 0.615 0.007 GO:0044822 MF 1 poly(A) RNA binding 1 O75152,Q53F19,Q9BY77,Q13769,O00148,Q8NI27,Q96T37,Q13838 150 1.52e-05 3561 13 12 0.923 0.003 GO:0070013 CC 1 intracellular organelle lumen 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 1.52e-05 3561 13 12 0.923 0.003 GO:0043233 CC 1 organelle lumen 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 1.52e-05 3561 13 12 0.923 0.003 GO:0031974 CC 1 membrane-enclosed lumen 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 1.58e-05 2770 13 11 0.846 0.004 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.72e-05 36 13 3 0.231 0.083 GO:0032784 BP 1 regulation of DNA-templated transcription, elongation 1 Q96FV9,Q13769,Q13838 150 2.28e-05 2869 13 11 0.846 0.004 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.38e-05 40 13 3 0.231 0.075 GO:2001021 BP 1 negative regulation of response to DNA damage stimulus 1 Q96FV9,Q13769,Q13838 150 3.79e-05 565 13 6 0.462 0.011 GO:0044427 CC 1 chromosomal part 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 3.80e-05 3013 13 11 0.846 0.004 GO:0090304 BP 1 nucleic acid metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 4.43e-05 3058 13 11 0.846 0.004 GO:0010467 BP 1 gene expression 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 5.26e-05 1336 13 8 0.615 0.006 GO:0003723 MF 1 RNA binding 1 O75152,Q53F19,Q9BY77,Q13769,O00148,Q8NI27,Q96T37,Q13838 150 5.81e-05 609 13 6 0.462 0.010 GO:0005694 CC 1 chromosome 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 1.24e-04 2644 13 10 0.769 0.004 GO:0006810 BP 1 transport 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.39e-04 3415 13 11 0.846 0.003 GO:0032991 CC 1 macromolecular complex 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.51e-04 3443 13 11 0.846 0.003 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.65e-04 2096 13 9 0.692 0.004 GO:0043234 CC 1 protein complex 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.77e-04 2748 13 10 0.769 0.004 GO:0051234 BP 1 establishment of localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.78e-04 3499 13 11 0.846 0.003 GO:0044249 BP 1 cellular biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.93e-04 2136 13 9 0.692 0.004 GO:0003676 MF 1 nucleic acid binding 1 O75152,Q53F19,Q9BY77,Q13769,O00148,Q8NI27,Q96T37,Q6I9Y2,Q13838 150 2.09e-04 3554 13 11 0.846 0.003 GO:0046483 BP 1 heterocycle metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.13e-04 3561 13 11 0.846 0.003 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.18e-04 3569 13 11 0.846 0.003 GO:1901576 BP 1 organic substance biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.52e-04 3620 13 11 0.846 0.003 GO:0009058 BP 1 biosynthetic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 2.99e-04 3681 13 11 0.846 0.003 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 6.08e-04 3948 13 11 0.846 0.003 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 6.26e-04 119 13 3 0.231 0.025 GO:2001020 BP 1 regulation of response to DNA damage stimulus 1 Q96FV9,Q13769,Q13838 150 7.24e-04 125 13 3 0.231 0.024 GO:0000077 BP 1 DNA damage checkpoint 1 Q96FV9,Q13769,Q13838 150 7.76e-04 128 13 3 0.231 0.023 GO:0003729 MF 1 mRNA binding 1 Q53F19,Q13769,Q8NI27 150 9.07e-04 135 13 3 0.231 0.022 GO:0031570 BP 1 DNA integrity checkpoint 1 Q96FV9,Q13769,Q13838 150 9.88e-04 2612 13 9 0.692 0.003 GO:1901363 MF 1 heterocyclic compound binding 1 O75152,Q53F19,Q9BY77,Q13769,O00148,Q8NI27,Q96T37,Q6I9Y2,Q13838 150 1.14e-03 2660 13 9 0.692 0.003 GO:0097159 MF 1 organic cyclic compound binding 1 O75152,Q53F19,Q9BY77,Q13769,O00148,Q8NI27,Q96T37,Q6I9Y2,Q13838 150 1.22e-03 3401 13 10 0.769 0.003 GO:0051179 BP 1 localization 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q6I9Y2,Q13838 150 1.32e-03 4264 13 11 0.846 0.003 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.78e-03 6671 13 13 1.000 0.002 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 2.20e-03 183 13 3 0.231 0.016 GO:0000075 BP 1 cell cycle checkpoint 1 Q96FV9,Q13769,Q13838 150 2.38e-03 44 13 2 0.154 0.045 GO:0010501 BP 1 RNA secondary structure unwinding 1 O00148,Q13838 150 2.47e-03 527 13 4 0.308 0.008 MI:hsa-let-7d* mi 1 MI:hsa-let-7d* 1 O75152,Q53F19,O00148,Q96T37 150 2.49e-03 1 13 1 0.077 1.000 GO:0002638 BP 1 negative regulation of immunoglobulin production 1 Q96FV9 150 2.49e-03 1 13 1 0.077 1.000 GO:0048297 BP 1 negative regulation of isotype switching to IgA isotypes 1 Q96FV9 150 2.49e-03 1 13 1 0.077 1.000 GO:0000446 CC 1 nucleoplasmic THO complex 1 Q6I9Y2 150 2.49e-03 1 13 1 0.077 1.000 GO:0045829 BP 1 negative regulation of isotype switching 1 Q96FV9 150 3.51e-03 215 13 3 0.231 0.014 GO:0045787 BP 1 positive regulation of cell cycle 1 Q96FV9,Q13769,Q13838 150 3.89e-03 5787 13 12 0.923 0.002 GO:0044446 CC 1 intracellular organelle part 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 4.62e-03 5877 13 12 0.923 0.002 GO:0044422 CC 1 organelle part 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 4.97e-03 2 13 1 0.077 0.500 GO:0048296 BP 1 regulation of isotype switching to IgA isotypes 1 Q96FV9 150 4.97e-03 2 13 1 0.077 0.500 GO:0060215 BP 1 primitive hemopoiesis 1 Q13769 150 4.97e-03 2 13 1 0.077 0.500 GO:0048290 BP 1 isotype switching to IgA isotypes 1 Q96FV9 150 5.17e-03 65 13 2 0.154 0.031 GO:0004004 MF 1 ATP-dependent RNA helicase activity 1 O00148,Q13838 150 5.32e-03 66 13 2 0.154 0.030 GO:0003724 MF 1 RNA helicase activity 1 O00148,Q13838 150 5.32e-03 66 13 2 0.154 0.030 GO:0008186 MF 1 RNA-dependent ATPase activity 1 O00148,Q13838 150 6.21e-03 4990 13 11 0.846 0.002 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 6.37e-03 265 13 3 0.231 0.011 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 O00148,Q96T37,Q13838 150 6.37e-03 265 13 3 0.231 0.011 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 O00148,Q96T37,Q13838 150 6.65e-03 269 13 3 0.231 0.011 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 O00148,Q96T37,Q13838 150 7.45e-03 3 13 1 0.077 0.333 GO:0002713 BP 1 negative regulation of B cell mediated immunity 1 Q96FV9 150 7.45e-03 3 13 1 0.077 0.333 GO:0002890 BP 1 negative regulation of immunoglobulin mediated immune response 1 Q96FV9 150 7.45e-03 3 13 1 0.077 0.333 GO:0043008 MF 1 ATP-dependent protein binding 1 Q13838 150 7.47e-03 592 13 4 0.308 0.007 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q96FV9,Q13769,O00148,Q13838 150 7.77e-03 80 13 2 0.154 0.025 GO:0016607 CC 1 nuclear speck 1 Q9BY77,Q96T37 150 8.40e-03 7517 13 13 1.000 0.002 GO:0043229 CC 1 intracellular organelle 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 9.37e-03 88 13 2 0.154 0.023 GO:0008026 MF 1 ATP-dependent helicase activity 1 O00148,Q13838 150 9.37e-03 88 13 2 0.154 0.023 GO:0070035 MF 1 purine NTP-dependent helicase activity 1 O00148,Q13838 150 9.92e-03 4 13 1 0.077 0.250 GO:0000340 MF 1 RNA 7-methylguanosine cap binding 1 Q53F19 150 1.14e-02 326 13 3 0.231 0.009 GO:0008380 BP 1 RNA splicing 1 O00148,Q96T37,Q13838 150 1.15e-02 5319 13 11 0.846 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 1.24e-02 5 13 1 0.077 0.200 GO:0045191 BP 1 regulation of isotype switching 1 Q96FV9 150 1.24e-02 5 13 1 0.077 0.200 GO:0030621 MF 1 U4 snRNA binding 1 Q13838 150 1.33e-02 446 13 3 0.231 0.007 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q96FV9,O00148,Q6I9Y2 150 1.49e-02 6 13 1 0.077 0.167 GO:0002823 BP 1 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q96FV9 150 1.50e-02 112 13 2 0.154 0.018 GO:0004386 MF 1 helicase activity 1 O00148,Q13838 150 1.62e-02 7906 13 13 1.000 0.002 GO:0043227 CC 1 membrane-bounded organelle 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 1.70e-02 376 13 3 0.231 0.008 GO:0045786 BP 1 negative regulation of cell cycle 1 Q96FV9,Q13769,Q13838 150 1.73e-02 7 13 1 0.077 0.143 GO:0005688 CC 1 U6 snRNP 1 Q13838 150 1.98e-02 8 13 1 0.077 0.125 GO:0002637 BP 1 regulation of immunoglobulin production 1 Q96FV9 150 1.98e-02 8 13 1 0.077 0.125 GO:0035162 BP 1 embryonic hemopoiesis 1 Q13769 150 1.98e-02 8 13 1 0.077 0.125 GO:0002820 BP 1 negative regulation of adaptive immune response 1 Q96FV9 150 1.98e-02 8 13 1 0.077 0.125 GO:0002889 BP 1 regulation of immunoglobulin mediated immune response 1 Q96FV9 150 2.07e-02 404 13 3 0.231 0.007 GO:0080135 BP 1 regulation of cellular response to stress 1 Q96FV9,Q13769,Q13838 150 2.07e-02 526 13 3 0.231 0.006 MI:hsa-let-7f-1* mi 1 MI:hsa-let-7f-1* 1 O75152,O00148,Q96T37 150 2.12e-02 531 13 3 0.231 0.006 MI:mmu-miR-467c mi 1 MI:mmu-miR-467c 1 Q96J01,Q8NI27,Q6I9Y2 150 2.23e-02 9 13 1 0.077 0.111 GO:0050869 BP 1 negative regulation of B cell activation 1 Q96FV9 150 2.23e-02 9 13 1 0.077 0.111 GO:0002712 BP 1 regulation of B cell mediated immunity 1 Q96FV9 150 2.23e-02 9 13 1 0.077 0.111 GO:0002701 BP 1 negative regulation of production of molecular mediator of immune response 1 Q96FV9 150 2.29e-02 546 13 3 0.231 0.005 MI:hsa-let-7b* mi 1 MI:hsa-let-7b* 1 O75152,O00148,Q96T37 150 2.29e-02 546 13 3 0.231 0.005 MI:hsa-let-7a* mi 1 MI:hsa-let-7a* 1 O75152,O00148,Q96T37 150 2.47e-02 10 13 1 0.077 0.100 GO:0002707 BP 1 negative regulation of lymphocyte mediated immunity 1 Q96FV9 150 2.47e-02 10 13 1 0.077 0.100 GO:0017070 MF 1 U6 snRNA binding 1 Q13838 150 2.47e-02 10 13 1 0.077 0.100 GO:0005687 CC 1 U4 snRNP 1 Q13838 150 2.53e-02 147 13 2 0.154 0.014 GO:0005681 CC 1 spliceosomal complex 1 O00148,Q13838 150 2.72e-02 11 13 1 0.077 0.091 GO:0045910 BP 1 negative regulation of DNA recombination 1 Q96FV9 150 2.97e-02 12 13 1 0.077 0.083 GO:0002704 BP 1 negative regulation of leukocyte mediated immunity 1 Q96FV9 150 2.97e-02 12 13 1 0.077 0.083 GO:0030224 BP 1 monocyte differentiation 1 Q13769 150 2.97e-02 12 13 1 0.077 0.083 GO:0034518 CC 1 RNA cap binding complex 1 Q53F19 150 2.97e-02 12 13 1 0.077 0.083 GO:1903131 BP 1 mononuclear cell differentiation 1 Q13769 150 3.06e-02 1960 13 6 0.462 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 3.06e-02 1960 13 6 0.462 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q96J01,Q96FV9,Q13769,Q8NI27,Q86W42,Q6I9Y2 150 3.21e-02 13 13 1 0.077 0.077 GO:0002208 BP 1 somatic diversification of immunoglobulins involved in immune response 1 Q96FV9 150 3.21e-02 13 13 1 0.077 0.077 GO:0045190 BP 1 isotype switching 1 Q96FV9 150 3.21e-02 13 13 1 0.077 0.077 GO:0000339 MF 1 RNA cap binding 1 Q53F19 150 3.21e-02 13 13 1 0.077 0.077 GO:0002204 BP 1 somatic recombination of immunoglobulin genes involved in immune response 1 Q96FV9 150 3.23e-02 896 13 4 0.308 0.004 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q96FV9,Q9BY77,Q13769,Q13838 150 3.27e-02 626 13 3 0.231 0.005 MI:mmu-miR-291b-3p mi 1 MI:mmu-miR-291b-3p 1 Q8NI27,Q96T37,Q6I9Y2 150 3.43e-02 638 13 3 0.231 0.005 MI:hsa-miR-519c-3p mi 1 MI:hsa-miR-519c-3p 1 Q8NI27,Q96T37,Q6I9Y2 150 3.46e-02 14 13 1 0.077 0.071 GO:0016447 BP 1 somatic recombination of immunoglobulin gene segments 1 Q96FV9 150 3.46e-02 14 13 1 0.077 0.071 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 Q96FV9 150 3.48e-02 8385 13 13 1.000 0.002 GO:0043226 CC 1 organelle 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 3.56e-02 922 13 4 0.308 0.004 GO:0010628 BP 1 positive regulation of gene expression 1 Q96FV9,Q9BY77,Q13769,Q13838 150 3.59e-02 4872 13 12 0.923 0.002 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q96J01,O75152,Q53F19,Q96FV9,Q9BY77,O00148,Q8NI27,Q86W42,Q8N9M1,Q96T37,Q6I9Y2,Q13838 150 3.68e-02 179 13 2 0.154 0.011 GO:0016604 CC 1 nuclear body 1 Q9BY77,Q96T37 150 3.84e-02 272 13 2 0.154 0.007 MI:hsa-miR-877* mi 1 MI:hsa-miR-877* 1 Q96J01,Q53F19 150 4.03e-02 956 13 4 0.308 0.004 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q96FV9,Q9BY77,Q13769,Q13838 150 4.12e-02 521 13 3 0.231 0.006 GO:0044451 CC 1 nucleoplasm part 1 Q9BY77,Q96T37,Q6I9Y2 150 4.25e-02 971 13 4 0.308 0.004 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q96FV9,Q9BY77,Q13769,Q13838 150 4.32e-02 6128 13 11 0.846 0.002 GO:0044238 BP 1 primary metabolic process 1 Q96J01,O75152,Q96FV9,Q9BY77,Q13769,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 4.40e-02 293 13 2 0.154 0.007 MI:hsa-miR-374a* mi 1 MI:hsa-miR-374a* 1 Q96FV9,Q8NI27 150 4.43e-02 18 13 1 0.077 0.056 GO:0002312 BP 1 B cell activation involved in immune response 1 Q96FV9 150 4.58e-02 993 13 4 0.308 0.004 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q96FV9,Q9BY77,Q13769,Q13838 150 4.92e-02 20 13 1 0.077 0.050 GO:0016445 BP 1 somatic diversification of immunoglobulins 1 Q96FV9 150 4.92e-02 20 13 1 0.077 0.050 GO:0016444 BP 1 somatic cell DNA recombination 1 Q96FV9 150 4.92e-02 20 13 1 0.077 0.050 GO:0002562 BP 1 somatic diversification of immune receptors via germline recombination within a single locus 1 Q96FV9 150 5.00e-02 152 13 3 0.231 0.020 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 O75152,Q8N9M1,Q96T37 150 5.00e-02 128 13 4 0.308 0.031 KEGG:03040 keg 1 Spliceosome 1 Q96J01,Q96FV9,Q8NI27,Q13838 150 5.00e-02 7 13 1 0.077 0.143 CORUM:785 cor 1 Exon junction complex 1 Q13838 150 5.00e-02 152 13 3 0.231 0.020 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 O75152,Q8N9M1,Q96T37 150 5.00e-02 152 13 3 0.231 0.020 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 O75152,Q8N9M1,Q96T37 150 5.00e-02 3292 13 10 0.769 0.003 HPA:016010_03 hpa 1 gallbladder; glandular cells[Uncertain,High] 1 Q96J01,Q53F19,Q96FV9,Q9BY77,O00148,Q8NI27,Q86W42,Q96T37,Q6I9Y2,Q13838 150 5.00e-02 1 13 1 0.077 1.000 HP:0030127 hp 1 Endometriosis 1 Q86W42 150 5.00e-02 152 13 3 0.231 0.020 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 O75152,Q8N9M1,Q96T37 150 5.00e-02 2173 13 6 0.462 0.003 GO:0010468 BP 1 regulation of gene expression 1 Q96FV9,Q9BY77,Q13769,O00148,Q96T37,Q13838 150 5.00e-02 1 13 1 0.077 1.000 HP:0030012 hp 1 Abnormal female reproductive system physiology 1 Q86W42 151 7.19e-05 20 2 2 1.000 0.100 CORUM:1332 cor 1 Large Drosha complex 1 Q13148,P31943 151 1.74e-03 2 2 1 0.500 0.500 CORUM:1287 cor 1 HNRPF-HNRPH1 complex 1 P31943 151 3.48e-03 4 2 1 0.500 0.250 CORUM:1288 cor 1 DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) 1 P31943 151 4.18e-03 1 2 1 0.500 1.000 OMIM:612069 omi 1 AMYOTROPHIC LATERAL SCLEROSIS 10 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA;ALS10FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, TARDBP-RELATED,INCLUDED;;FRONTOTEMPORAL DEMENTIA WITH TDP43 INCLUSIONS, TARDBP-RELATED, INCLUDED;;FTLD-TDP, TARDBP-RELATED, INCLUDED 1 Q13148 151 5.04e-03 904 2 2 1.000 0.002 TF:M01273_1 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 1 Q13148,P31943 151 5.83e-03 972 2 2 1.000 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q13148,P31943 151 6.56e-03 1031 2 2 1.000 0.002 TF:M00260_0 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 0 1 Q13148,P31943 151 7.14e-03 1 2 1 0.500 1.000 GO:0071765 BP 1 nuclear inner membrane organization 1 Q13148 151 7.14e-03 1 2 1 0.500 1.000 GO:0030264 BP 1 nuclear fragmentation involved in apoptotic nuclear change 1 Q13148 151 9.54e-03 11 2 1 0.500 0.091 CORUM:3082 cor 1 DGCR8 multiprotein complex 1 P31943 151 9.69e-03 10 2 1 0.500 0.100 HP:0000727 hp 1 Frontal lobe dementia 1 Q13148 151 1.11e-02 298 2 2 1.000 0.007 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 Q13148,P31943 151 1.16e-02 12 2 1 0.500 0.083 HP:0007308 hp 1 Extrapyramidal dyskinesia 1 Q13148 151 1.26e-02 317 2 2 1.000 0.006 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 Q13148,P31943 151 1.45e-02 15 2 1 0.500 0.067 HP:0002442 hp 1 Dyscalculia 1 Q13148 151 1.46e-02 341 2 2 1.000 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 Q13148,P31943 151 1.49e-02 345 2 2 1.000 0.006 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 Q13148,P31943 151 1.50e-02 96 2 1 0.500 0.010 TF:M04204_0 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 0 1 P31943 151 1.53e-02 349 2 2 1.000 0.006 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 Q13148,P31943 151 1.55e-02 16 2 1 0.500 0.062 HP:0002273 hp 1 Tetraparesis 1 Q13148 151 1.58e-02 101 2 1 0.500 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 Q13148 151 1.60e-02 357 2 2 1.000 0.006 HPA:034010_13 hpa 1 skeletal muscle; myocytes[Supportive,High] 1 Q13148,P31943 151 1.65e-02 17 2 1 0.500 0.059 HP:0000605 hp 1 Supranuclear gaze palsy 1 Q13148 151 1.71e-02 369 2 2 1.000 0.005 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 Q13148,P31943 151 1.80e-02 1709 2 2 1.000 0.001 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q13148,P31943 151 1.92e-02 123 2 1 0.500 0.008 TF:M00261_0 tf 1 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN; match class: 0 1 Q13148 151 1.96e-02 1784 2 2 1.000 0.001 TF:M07409_1 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 1 Q13148,P31943 151 2.00e-02 128 2 1 0.500 0.008 TF:M06358_0 tf 1 Factor: ZNF787; motif: NTGRTAAGGCYM; match class: 0 1 Q13148 151 2.05e-02 404 2 2 1.000 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q13148,P31943 151 2.08e-02 133 2 1 0.500 0.008 TF:M06516_0 tf 1 Factor: ZNF418; motif: NGGGKAGCCGT; match class: 0 1 P31943 151 2.09e-02 408 2 2 1.000 0.005 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q13148,P31943 151 2.14e-02 3 2 1 0.500 0.333 GO:0071763 BP 1 nuclear membrane organization 1 Q13148 151 2.17e-02 416 2 2 1.000 0.005 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 Q13148,P31943 151 2.23e-02 143 2 1 0.500 0.007 TF:M04202_0 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 0 1 P31943 151 2.30e-02 147 2 1 0.500 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 Q13148 151 2.32e-02 24 2 1 0.500 0.042 HP:0008756 hp 1 Bowing of the vocal cords 1 Q13148 151 2.56e-02 164 2 1 0.500 0.006 TF:M07439_0 tf 1 Factor: TEF; motif: GTTACGTAAT; match class: 0 1 P31943 151 2.59e-02 454 2 2 1.000 0.004 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q13148,P31943 151 2.59e-02 2048 2 2 1.000 0.001 TF:M02011_1 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 1 Q13148,P31943 151 2.61e-02 27 2 1 0.500 0.037 HP:0001348 hp 1 Brisk reflexes 1 Q13148 151 2.70e-02 28 2 1 0.500 0.036 HP:0030223 hp 1 Perseveration 1 Q13148 151 2.70e-02 28 2 1 0.500 0.036 HP:0007024 hp 1 Pseudobulbar paralysis 1 Q13148 151 2.76e-02 177 2 1 0.500 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 P31943 151 2.80e-02 29 2 1 0.500 0.034 HP:0002145 hp 1 Frontotemporal dementia 1 Q13148 151 2.80e-02 29 2 1 0.500 0.034 HP:0002314 hp 1 Degeneration of the lateral corticospinal tracts 1 Q13148 151 2.82e-02 181 2 1 0.500 0.006 TF:M00420_0 tf 1 Factor: MEIS1A:HOXA9; motif: TGACAGKTTTAYGA; match class: 0 1 P31943 151 2.85e-02 183 2 1 0.500 0.005 TF:M06623_0 tf 1 Factor: ZNF778; motif: NTMAGWTTGCGC; match class: 0 1 Q13148 151 2.90e-02 30 2 1 0.500 0.033 HP:0002483 hp 1 Bulbar signs 1 Q13148 151 2.90e-02 30 2 1 0.500 0.033 HP:0007372 hp 1 Atrophy/Degeneration involving the corticospinal tracts 1 Q13148 151 2.94e-02 484 2 2 1.000 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q13148,P31943 151 2.99e-02 31 2 1 0.500 0.032 HP:0002300 hp 1 Mutism 1 Q13148 151 2.99e-02 31 2 1 0.500 0.032 HP:0000734 hp 1 Disinhibition 1 Q13148 151 2.99e-02 31 2 1 0.500 0.032 HP:0002835 hp 1 Aspiration 1 Q13148 151 3.00e-02 489 2 2 1.000 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q13148,P31943 151 3.09e-02 32 2 1 0.500 0.031 HP:0002492 hp 1 Abnormality of the corticospinal tract 1 Q13148 151 3.18e-02 33 2 1 0.500 0.030 HP:0000746 hp 1 Delusions 1 Q13148 151 3.18e-02 33 2 1 0.500 0.030 HP:0003805 hp 1 Rimmed vacuoles 1 Q13148 151 3.26e-02 209 2 1 0.500 0.005 TF:M04201_0 tf 1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 0 1 P31943 151 3.28e-02 34 2 1 0.500 0.029 HP:0007354 hp 1 Amyotrophic lateral sclerosis 1 Q13148 151 3.28e-02 34 2 1 0.500 0.029 HP:0002366 hp 1 Abnormal lower motor neuron morphology 1 Q13148 151 3.28e-02 34 2 1 0.500 0.029 HP:0002385 hp 1 Paraparesis 1 Q13148 151 3.28e-02 326 2 2 1.000 0.006 GO:0008380 BP 1 RNA splicing 1 Q13148,P31943 151 3.38e-02 35 2 1 0.500 0.029 HP:0002398 hp 1 Degeneration of anterior horn cells 1 Q13148 151 3.38e-02 35 2 1 0.500 0.029 HP:0000719 hp 1 Inappropriate behavior 1 Q13148 151 3.38e-02 35 2 1 0.500 0.029 HP:0001308 hp 1 Tongue fasciculations 1 Q13148 151 3.38e-02 35 2 1 0.500 0.029 HP:0002127 hp 1 Abnormal upper motor neuron morphology 1 Q13148 151 3.47e-02 36 2 1 0.500 0.028 HP:0006802 hp 1 Abnormal anterior horn cell morphology 1 Q13148 151 3.47e-02 36 2 1 0.500 0.028 HP:0100299 hp 1 Muscle fiber inclusion bodies 1 Q13148 151 3.47e-02 36 2 1 0.500 0.028 HP:0003323 hp 1 Progressive muscle weakness 1 Q13148 151 3.54e-02 531 2 2 1.000 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q13148,P31943 151 3.57e-02 37 2 1 0.500 0.027 HP:0006957 hp 1 Loss of ability to walk 1 Q13148 151 3.57e-02 37 2 1 0.500 0.027 HP:0010546 hp 1 Muscle fibrillation 1 Q13148 151 3.66e-02 540 2 2 1.000 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q13148,P31943 151 3.66e-02 38 2 1 0.500 0.026 HP:0000741 hp 1 Apathy 1 Q13148 151 3.75e-02 9 2 1 0.500 0.111 OMIM:607485 omi 1 FTLD-TDP 1 Q13148 151 3.76e-02 39 2 1 0.500 0.026 HP:0008777 hp 1 Abnormality of the vocal cords 1 Q13148 151 3.76e-02 39 2 1 0.500 0.026 HP:0000745 hp 1 Diminished motivation 1 Q13148 151 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 Q13148,P31943 151 3.85e-02 40 2 1 0.500 0.025 HP:0003547 hp 1 Shoulder girdle muscle weakness 1 Q13148 151 3.95e-02 41 2 1 0.500 0.024 HP:0000751 hp 1 Personality changes 1 Q13148 151 3.99e-02 564 2 2 1.000 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q13148,P31943 151 3.99e-02 564 2 2 1.000 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q13148,P31943 151 4.04e-02 567 2 2 1.000 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 Q13148,P31943 151 4.05e-02 42 2 1 0.500 0.024 HP:0002505 hp 1 Progressive inability to walk 1 Q13148 151 4.05e-02 42 2 1 0.500 0.024 HP:0002463 hp 1 Language impairment 1 Q13148 151 4.14e-02 43 2 1 0.500 0.023 HP:0100660 hp 1 Dyskinesia 1 Q13148 151 4.24e-02 44 2 1 0.500 0.023 HP:0007373 hp 1 Motor neuron atrophy 1 Q13148 151 4.33e-02 45 2 1 0.500 0.022 HP:0010535 hp 1 Sleep apnea 1 Q13148 151 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 P31943 151 4.46e-02 596 2 2 1.000 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q13148,P31943 151 4.54e-02 292 2 1 0.500 0.003 TF:M07138_0 tf 1 Factor: p63; motif: NNRCAWGYNCARRCWTGYNN; match class: 0 1 P31943 151 4.62e-02 48 2 1 0.500 0.021 HP:0030182 hp 1 Tetraplegia/tetraparesis 1 Q13148 151 4.62e-02 48 2 1 0.500 0.021 HP:0030810 hp 1 Abnormal tongue physiology 1 Q13148 151 4.64e-02 608 2 2 1.000 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q13148,P31943 151 4.76e-02 616 2 2 1.000 0.003 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 Q13148,P31943 151 4.77e-02 307 2 1 0.500 0.003 TF:M06527_0 tf 1 Factor: ZNF675; motif: TGAAAGGGGA; match class: 0 1 P31943 151 4.81e-02 50 2 1 0.500 0.020 HP:0002200 hp 1 Pseudobulbar signs 1 Q13148 151 4.89e-02 624 2 2 1.000 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q13148,P31943 151 4.90e-02 51 2 1 0.500 0.020 HP:0002174 hp 1 Postural tremor 1 Q13148 151 4.95e-02 2831 2 2 1.000 0.001 TF:M01273_0 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 0 1 Q13148,P31943 151 4.96e-02 281 2 1 0.500 0.004 MI:hsa-miR-144* mi 1 MI:hsa-miR-144* 1 P31943 151 4.97e-02 320 2 1 0.500 0.003 TF:M06344_0 tf 1 Factor: ZNF530; motif: NGGGCAATWAYA; match class: 0 1 P31943 151 5.00e-02 12 2 1 0.500 0.083 OMIM:600274 omi 1 Frontotemporal Lobar Degeneration 1 Q13148 151 5.00e-02 631 2 2 1.000 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q13148,P31943 151 5.00e-02 52 2 1 0.500 0.019 HP:0001283 hp 1 Bulbar palsy 1 Q13148 151 5.00e-02 27 2 1 0.500 0.037 REAC:6803529 rea 1 FGFR2 alternative splicing 1 P31943 151 5.00e-02 52 2 1 0.500 0.019 HP:0002529 hp 1 Neuronal loss in central nervous system 1 Q13148 151 5.00e-02 7 2 1 0.500 0.143 GO:0043922 BP 1 negative regulation by host of viral transcription 1 Q13148 152 3.92e-03 25 2 1 0.500 0.040 TF:M06861_0 tf 1 Factor: ZNF484; motif: NGRTAGGGGAAA; match class: 0 1 Q8N2R8 152 4.03e-03 808 2 2 1.000 0.002 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 Q15173,Q8N2R8 152 7.37e-03 47 2 1 0.500 0.021 TF:M06924_0 tf 1 Factor: ZNF236; motif: NGGGGTAATTCT; match class: 0 1 Q8N2R8 152 9.25e-03 59 2 1 0.500 0.017 TF:M05523_0 tf 1 Factor: ZBTB46; motif: NGGGGGATAGN; match class: 0 1 Q15173 152 9.56e-03 61 2 1 0.500 0.016 TF:M01239_1 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 1 1 Q8N2R8 152 1.15e-02 1366 2 2 1.000 0.001 TF:M00264_0 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 0 1 Q15173,Q8N2R8 152 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q8N2R8 152 1.71e-02 109 2 1 0.500 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q8N2R8 152 2.13e-02 136 2 1 0.500 0.007 TF:M05522_0 tf 1 Factor: ZNF341; motif: NTGGGGGGGGGG; match class: 0 1 Q15173 152 2.19e-02 140 2 1 0.500 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q8N2R8 152 2.54e-02 41 2 1 0.500 0.024 GO:0019888 MF 1 protein phosphatase regulator activity 1 Q15173 152 2.65e-02 170 2 1 0.500 0.006 TF:M06125_0 tf 1 Factor: ZNF823; motif: NGRGGGAGGAGG; match class: 0 1 Q15173 152 2.68e-02 2083 2 2 1.000 0.001 TF:M01871_0 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 0 1 Q15173,Q8N2R8 152 2.68e-02 172 2 1 0.500 0.006 TF:M07351_1 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 1 1 Q8N2R8 152 2.72e-02 2098 2 2 1.000 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q15173,Q8N2R8 152 2.78e-02 178 2 1 0.500 0.006 TF:M03839_1 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 1 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:5467337 rea 1 APC truncation mutants have impaired AXIN binding 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:5467348 rea 1 Truncations of AMER1 destabilize the destruction complex 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:5467340 rea 1 AXIN missense mutants destabilize the destruction complex 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:4839748 rea 1 AMER1 mutants destabilize the destruction complex 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:4839744 rea 1 truncated APC mutants destabilize the destruction complex 1 Q15173 152 2.80e-02 14 2 1 0.500 0.071 REAC:4839735 rea 1 AXIN mutants destabilize the destruction complex, activating WNT signaling 1 Q15173 152 2.95e-02 189 2 1 0.500 0.005 TF:M00053_1 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 1 1 Q8N2R8 152 3.00e-02 15 2 1 0.500 0.067 REAC:5358747 rea 1 S33 mutants of beta-catenin aren't phosphorylated 1 Q15173 152 3.00e-02 15 2 1 0.500 0.067 REAC:4839743 rea 1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1 Q15173 152 3.00e-02 15 2 1 0.500 0.067 REAC:5358752 rea 1 T41 mutants of beta-catenin aren't phosphorylated 1 Q15173 152 3.00e-02 15 2 1 0.500 0.067 REAC:5358751 rea 1 S45 mutants of beta-catenin aren't phosphorylated 1 Q15173 152 3.00e-02 15 2 1 0.500 0.067 REAC:5358749 rea 1 S37 mutants of beta-catenin aren't phosphorylated 1 Q15173 152 3.00e-02 15 2 1 0.500 0.067 REAC:5339716 rea 1 Misspliced GSK3beta mutants stabilize beta-catenin 1 Q15173 152 3.20e-02 16 2 1 0.500 0.062 REAC:432142 rea 1 Platelet sensitization by LDL 1 Q15173 152 3.29e-02 2310 2 2 1.000 0.001 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 Q15173,Q8N2R8 152 3.40e-02 17 2 1 0.500 0.059 REAC:196299 rea 1 Beta-catenin phosphorylation cascade 1 Q15173 152 3.55e-02 228 2 1 0.500 0.004 TF:M01306_1 tf 1 Factor: ZABC1; motif: ATTCCNAC; match class: 1 1 Q8N2R8 152 3.71e-02 60 2 1 0.500 0.017 GO:0036498 BP 1 IRE1-mediated unfolded protein response 1 Q15173 152 3.80e-02 19 2 1 0.500 0.053 REAC:389513 rea 1 CTLA4 inhibitory signaling 1 Q15173 152 3.92e-02 252 2 1 0.500 0.004 TF:M01871_1 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 1 1 Q8N2R8 152 4.01e-02 2548 2 2 1.000 0.001 TF:M00106_0 tf 1 Factor: CDP; motif: NATYGATSSS; match class: 0 1 Q15173,Q8N2R8 152 4.30e-02 2641 2 2 1.000 0.001 TF:M00947_0 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 0 1 Q15173,Q8N2R8 152 4.61e-02 297 2 1 0.500 0.003 TF:M06747_0 tf 1 Factor: ZNF225; motif: KGRWGCWAANGM; match class: 0 1 Q8N2R8 152 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q8N2R8 152 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 Q8N2R8 152 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q15173,Q8N2R8 152 5.00e-02 25 2 1 0.500 0.040 REAC:5673000 rea 1 RAF activation 1 Q15173 152 5.00e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 Q15173 152 5.00e-02 81 2 1 0.500 0.012 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 Q15173 152 5.00e-02 407 2 2 1.000 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 Q15173,Q8N2R8 153 1.34e-03 1 3 1 0.333 1.000 OMIM:615833 omi 1 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 21; EIEE21 1 Q8NC96 153 2.64e-03 2 3 1 0.333 0.500 GO:0044393 CC 1 microspike 1 Q16658 153 3.96e-03 3 3 1 0.333 0.333 GO:0030035 BP 1 microspike assembly 1 Q16658 153 5.28e-03 4 3 1 0.333 0.250 GO:0071803 BP 1 positive regulation of podosome assembly 1 Q16658 153 6.60e-03 5 3 1 0.333 0.200 GO:0032534 BP 1 regulation of microvillus assembly 1 Q16658 153 7.92e-03 6 3 1 0.333 0.167 GO:0090091 BP 1 positive regulation of extracellular matrix disassembly 1 Q16658 153 9.24e-03 7 3 1 0.333 0.143 GO:0035089 BP 1 establishment of apical/basal cell polarity 1 Q16658 153 9.24e-03 7 3 1 0.333 0.143 GO:0071437 CC 1 invadopodium 1 Q16658 153 1.06e-02 8 3 1 0.333 0.125 GO:0032530 BP 1 regulation of microvillus organization 1 Q16658 153 1.06e-02 8 3 1 0.333 0.125 GO:0061162 BP 1 establishment of monopolar cell polarity 1 Q16658 153 1.19e-02 9 3 1 0.333 0.111 GO:0061339 BP 1 establishment or maintenance of monopolar cell polarity 1 Q16658 153 1.19e-02 9 3 1 0.333 0.111 GO:0071801 BP 1 regulation of podosome assembly 1 Q16658 153 1.19e-02 9 3 1 0.333 0.111 GO:0010592 BP 1 positive regulation of lamellipodium assembly 1 Q16658 153 1.45e-02 11 3 1 0.333 0.091 GO:0002102 CC 1 podosome 1 Q16658 153 1.71e-02 13 3 1 0.333 0.077 GO:1903055 BP 1 positive regulation of extracellular matrix organization 1 Q16658 153 1.71e-02 13 3 1 0.333 0.077 GO:0010715 BP 1 regulation of extracellular matrix disassembly 1 Q16658 153 1.85e-02 14 3 1 0.333 0.071 GO:0071800 BP 1 podosome assembly 1 Q16658 153 1.98e-02 15 3 1 0.333 0.067 GO:0051491 BP 1 positive regulation of filopodium assembly 1 Q16658 153 2.09e-02 2974 3 3 1.000 0.001 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 Q16658,Q8NC96,Q9NVZ3 153 2.11e-02 19 3 1 0.333 0.053 HP:0010851 hp 1 EEG with burst suppression 1 Q8NC96 153 2.24e-02 17 3 1 0.333 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 Q16658 153 2.24e-02 17 3 1 0.333 0.059 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 Q16658 153 2.33e-02 21 3 1 0.333 0.048 HP:0010818 hp 1 Generalized tonic seizures 1 Q8NC96 153 2.37e-02 18 3 1 0.333 0.056 GO:0030033 BP 1 microvillus assembly 1 Q16658 153 2.37e-02 18 3 1 0.333 0.056 GO:0030125 CC 1 clathrin vesicle coat 1 Q9NVZ3 153 2.55e-02 23 3 1 0.333 0.043 HP:0007105 hp 1 Infantile encephalopathy 1 Q8NC96 153 2.77e-02 21 3 1 0.333 0.048 GO:0031941 CC 1 filamentous actin 1 Q16658 153 2.77e-02 21 3 1 0.333 0.048 GO:0032528 BP 1 microvillus organization 1 Q16658 153 2.88e-02 26 3 1 0.333 0.038 HP:0001151 hp 1 Impaired horizontal smooth pursuit 1 Q8NC96 153 3.03e-02 23 3 1 0.333 0.043 GO:0035088 BP 1 establishment or maintenance of apical/basal cell polarity 1 Q16658 153 3.03e-02 23 3 1 0.333 0.043 GO:0061245 BP 1 establishment or maintenance of bipolar cell polarity 1 Q16658 153 3.03e-02 23 3 1 0.333 0.043 GO:1903053 BP 1 regulation of extracellular matrix organization 1 Q16658 153 3.29e-02 25 3 1 0.333 0.040 GO:0030118 CC 1 clathrin coat 1 Q9NVZ3 153 3.31e-02 30 3 1 0.333 0.033 HP:0012469 hp 1 Infantile spasms 1 Q8NC96 153 3.56e-02 27 3 1 0.333 0.037 GO:0051489 BP 1 regulation of filopodium assembly 1 Q16658 153 3.56e-02 27 3 1 0.333 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q16658 153 3.64e-02 33 3 1 0.333 0.030 HP:0006808 hp 1 Cerebral hypomyelination 1 Q8NC96 153 3.64e-02 33 3 1 0.333 0.030 HP:0011097 hp 1 Epileptic spasms 1 Q8NC96 153 3.82e-02 29 3 1 0.333 0.034 GO:0005902 CC 1 microvillus 1 Q16658 153 3.86e-02 35 3 1 0.333 0.029 HP:0003623 hp 1 Neonatal onset 1 Q8NC96 153 3.95e-02 30 3 1 0.333 0.033 GO:0005905 CC 1 clathrin-coated pit 1 Q9NVZ3 153 4.08e-02 31 3 1 0.333 0.032 GO:0030032 BP 1 lamellipodium assembly 1 Q16658 153 4.08e-02 31 3 1 0.333 0.032 GO:0097517 CC 1 contractile actin filament bundle 1 Q16658 153 4.08e-02 31 3 1 0.333 0.032 GO:0001725 CC 1 stress fiber 1 Q16658 153 4.40e-02 40 3 1 0.333 0.025 HP:0002883 hp 1 Hyperventilation 1 Q8NC96 153 4.40e-02 40 3 1 0.333 0.025 HP:0002375 hp 1 Hypokinesia 1 Q8NC96 153 4.48e-02 34 3 1 0.333 0.029 GO:0032432 CC 1 actin filament bundle 1 Q16658 153 4.53e-02 522 3 2 0.667 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q8NC96,Q9NVZ3 153 4.74e-02 36 3 1 0.333 0.028 GO:0030120 CC 1 vesicle coat 1 Q9NVZ3 153 4.83e-02 44 3 1 0.333 0.023 HP:0002373 hp 1 Febrile seizures 1 Q8NC96 153 4.87e-02 37 3 1 0.333 0.027 GO:0042641 CC 1 actomyosin 1 Q16658 153 4.87e-02 37 3 1 0.333 0.027 GO:0046847 BP 1 filopodium assembly 1 Q16658 153 4.94e-02 45 3 1 0.333 0.022 HP:0002374 hp 1 Diminished movement 1 Q8NC96 153 5.00e-02 38 3 1 0.333 0.026 OMIM:308350 omi 1 Early Infantile Epileptic Encephalopathy 1 Q8NC96 153 5.00e-02 549 3 2 0.667 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q8NC96,Q9NVZ3 153 5.00e-02 3 3 1 0.333 0.333 TF:M05774_0 tf 1 Factor: ZNF697; motif: KGGTACGAGGGM; match class: 0 1 Q16658 154 8.22e-04 1 2 1 0.500 1.000 GO:0070335 MF 1 aspartate binding 1 P27708 154 1.64e-03 2 2 1 0.500 0.500 GO:0004151 MF 1 dihydroorotase activity 1 P27708 154 1.64e-03 2 2 1 0.500 0.500 GO:0004088 MF 1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 1 P27708 154 1.64e-03 2 2 1 0.500 0.500 GO:0016743 MF 1 carboxyl- or carbamoyltransferase activity 1 P27708 154 1.64e-03 2 2 1 0.500 0.500 GO:0004087 MF 1 carbamoyl-phosphate synthase (ammonia) activity 1 P27708 154 1.64e-03 2 2 1 0.500 0.500 GO:0004070 MF 1 aspartate carbamoyltransferase activity 1 P27708 154 2.47e-03 3 2 1 0.500 0.333 GO:0006207 BP 1 'de novo' pyrimidine nucleobase biosynthetic process 1 P27708 154 2.47e-03 3 2 1 0.500 0.333 GO:0019856 BP 1 pyrimidine nucleobase biosynthetic process 1 P27708 154 2.47e-03 3 2 1 0.500 0.333 GO:0048312 BP 1 intracellular distribution of mitochondria 1 O75153 154 3.30e-03 21 2 1 0.500 0.048 TF:M07117_1 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 1 1 O75153 154 3.39e-03 6 2 1 0.500 0.167 REAC:500753 rea 1 Pyrimidine biosynthesis 1 P27708 154 4.11e-03 5 2 1 0.500 0.200 GO:0016812 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1 P27708 154 4.11e-03 5 2 1 0.500 0.200 GO:0006526 BP 1 arginine biosynthetic process 1 P27708 154 4.24e-03 27 2 1 0.500 0.037 TF:M07402_1 tf 1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 1 1 O75153 154 4.35e-03 840 2 2 1.000 0.002 TF:M00172_1 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 1 1 P27708,O75153 154 4.93e-03 6 2 1 0.500 0.167 GO:0048311 BP 1 mitochondrion distribution 1 O75153 154 5.18e-03 33 2 1 0.500 0.030 TF:M05798_0 tf 1 Factor: ZNF517; motif: NGGGAAGGCGGC; match class: 0 1 O75153 154 6.63e-03 1037 2 2 1.000 0.002 TF:M07281_0 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 0 1 P27708,O75153 154 7.15e-03 1 2 1 0.500 1.000 OMIM:616457 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iz; CDG1Z 1 P27708 154 7.66e-03 945 2 2 1.000 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P27708,O75153 154 8.21e-03 10 2 1 0.500 0.100 GO:0016884 MF 1 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1 P27708 154 8.21e-03 10 2 1 0.500 0.100 GO:0000050 BP 1 urea cycle 1 P27708 154 9.04e-03 11 2 1 0.500 0.091 GO:0006206 BP 1 pyrimidine nucleobase metabolic process 1 P27708 154 9.04e-03 11 2 1 0.500 0.091 GO:0006541 BP 1 glutamine metabolic process 1 P27708 154 9.04e-03 11 2 1 0.500 0.091 GO:0019627 BP 1 urea metabolic process 1 P27708 154 9.86e-03 12 2 1 0.500 0.083 GO:0071941 BP 1 nitrogen cycle metabolic process 1 P27708 154 9.86e-03 12 2 1 0.500 0.083 GO:0046112 BP 1 nucleobase biosynthetic process 1 P27708 154 1.05e-02 67 2 1 0.500 0.015 TF:M06141_0 tf 1 Factor: ZNF708; motif: NGKGGAAAAGGW; match class: 0 1 O75153 154 1.07e-02 13 2 1 0.500 0.077 GO:0006525 BP 1 arginine metabolic process 1 P27708 154 1.15e-02 14 2 1 0.500 0.071 GO:0043195 CC 1 terminal bouton 1 P27708 154 1.15e-02 14 2 1 0.500 0.071 GO:0009084 BP 1 glutamine family amino acid biosynthetic process 1 P27708 154 1.19e-02 76 2 1 0.500 0.013 TF:M04176_0 tf 1 Factor: MAX; motif: NNCACGTGNN; match class: 0 1 O75153 154 1.30e-02 83 2 1 0.500 0.012 TF:M05381_1 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 1 1 O75153 154 1.35e-02 24 2 1 0.500 0.042 REAC:73848 rea 1 Pyrimidine metabolism 1 P27708 154 1.40e-02 1507 2 2 1.000 0.001 TF:M00403_0 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 0 1 P27708,O75153 154 1.48e-02 1547 2 2 1.000 0.001 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 P27708,O75153 154 1.48e-02 1547 2 2 1.000 0.001 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 P27708,O75153 154 1.49e-02 1556 2 2 1.000 0.001 TF:M00983_1 tf 1 Factor: MAF; motif: NGCTGAGTCAN; match class: 1 1 P27708,O75153 154 1.64e-02 20 2 1 0.500 0.050 GO:0046134 BP 1 pyrimidine nucleoside biosynthetic process 1 P27708 154 1.64e-02 105 2 1 0.500 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 P27708 154 1.70e-02 1658 2 2 1.000 0.001 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 P27708,O75153 154 1.79e-02 1703 2 2 1.000 0.001 TF:M00940_0 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 0 1 P27708,O75153 154 1.81e-02 22 2 1 0.500 0.045 GO:0043679 CC 1 axon terminus 1 P27708 154 1.86e-02 119 2 1 0.500 0.008 TF:M00693_1 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 1 1 O75153 154 1.89e-02 23 2 1 0.500 0.043 GO:0017144 BP 1 drug metabolic process 1 P27708 154 1.89e-02 23 2 1 0.500 0.043 GO:0051646 BP 1 mitochondrion localization 1 O75153 154 1.92e-02 123 2 1 0.500 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 O75153 154 1.94e-02 1775 2 2 1.000 0.001 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 P27708,O75153 154 1.97e-02 24 2 1 0.500 0.042 GO:0009112 BP 1 nucleobase metabolic process 1 P27708 154 2.13e-02 1859 2 2 1.000 0.001 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 P27708,O75153 154 2.13e-02 26 2 1 0.500 0.038 GO:0072528 BP 1 pyrimidine-containing compound biosynthetic process 1 P27708 154 2.19e-02 1886 2 2 1.000 0.001 TF:M00217_1 tf 1 Factor: USF; motif: NCACGTGN; match class: 1 1 P27708,O75153 154 2.27e-02 1920 2 2 1.000 0.001 TF:M00736_0 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 0 1 P27708,O75153 154 2.30e-02 28 2 1 0.500 0.036 GO:0044306 CC 1 neuron projection terminus 1 P27708 154 2.37e-02 152 2 1 0.500 0.007 TF:M00763_1 tf 1 Factor: PPAR; motif: TGACCTTTGNCCY; match class: 1 1 O75153 154 2.44e-02 156 2 1 0.500 0.006 TF:M06481_0 tf 1 Factor: ZNF433; motif: AAMCTGATGMCA; match class: 0 1 P27708 154 2.48e-02 159 2 1 0.500 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 O75153 154 2.54e-02 31 2 1 0.500 0.032 GO:0006213 BP 1 pyrimidine nucleoside metabolic process 1 P27708 154 2.79e-02 34 2 1 0.500 0.029 GO:0016597 MF 1 amino acid binding 1 P27708 154 2.86e-02 4 2 1 0.500 0.250 OMIM:212065 omi 1 Congenital Disorder of Glycosylation Type I 1 P27708 154 3.02e-02 2213 2 2 1.000 0.001 TF:M07065_1 tf 1 Factor: STAT3; motif: TTCYGGGAAN; match class: 1 1 P27708,O75153 154 3.14e-02 2255 2 2 1.000 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 P27708,O75153 154 3.16e-02 203 2 1 0.500 0.005 TF:M07375_1 tf 1 Factor: BCL-6; motif: TTCCTAGAAA; match class: 1 1 P27708 154 3.20e-02 205 2 1 0.500 0.005 TF:M01299_0 tf 1 Factor: MECP2; motif: CCGGNNTTWA; match class: 0 1 P27708 154 3.45e-02 42 2 1 0.500 0.024 GO:0009064 BP 1 glutamine family amino acid metabolic process 1 P27708 154 3.45e-02 42 2 1 0.500 0.024 GO:0016879 MF 1 ligase activity, forming carbon-nitrogen bonds 1 P27708 154 3.58e-02 2410 2 2 1.000 0.001 TF:M03829_0 tf 1 Factor: HNF-6; motif: AATCAATA; match class: 0 1 P27708,O75153 154 3.63e-02 233 2 1 0.500 0.004 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 P27708 154 3.77e-02 46 2 1 0.500 0.022 GO:0016363 CC 1 nuclear matrix 1 P27708 154 3.78e-02 243 2 1 0.500 0.004 TF:M05454_0 tf 1 Factor: ZBTB3; motif: KGGTKYCAAC; match class: 0 1 P27708 154 3.82e-02 2489 2 2 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 P27708,O75153 154 3.94e-02 48 2 1 0.500 0.021 GO:0033267 CC 1 axon part 1 P27708 154 4.03e-02 259 2 1 0.500 0.004 TF:M00764_1 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 1 1 O75153 154 4.03e-02 259 2 1 0.500 0.004 TF:M07350_1 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 1 1 P27708 154 4.10e-02 50 2 1 0.500 0.020 GO:1901607 BP 1 alpha-amino acid biosynthetic process 1 P27708 154 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 O75153 154 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 O75153 154 4.37e-02 281 2 1 0.500 0.004 TF:M03919_1 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 1 1 O75153 154 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 P27708 154 4.47e-02 288 2 1 0.500 0.003 TF:M06789_0 tf 1 Factor: ZNF835; motif: NCGRGKGAAMCC; match class: 0 1 P27708 154 4.51e-02 55 2 1 0.500 0.018 GO:0072527 BP 1 pyrimidine-containing compound metabolic process 1 P27708 154 4.53e-02 2710 2 2 1.000 0.001 TF:M02019_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 P27708,O75153 154 4.53e-02 2710 2 2 1.000 0.001 TF:M03794_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 P27708,O75153 154 4.75e-02 58 2 1 0.500 0.017 GO:0018107 BP 1 peptidyl-threonine phosphorylation 1 P27708 154 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 O75153 154 4.98e-02 321 2 1 0.500 0.003 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 O75153 154 5.00e-02 7 2 1 0.500 0.143 OMIM:236750 omi 1 Hydrops Fetalis 1 P27708 154 5.00e-02 61 2 1 0.500 0.016 GO:0018210 BP 1 peptidyl-threonine modification 1 P27708 154 5.00e-02 3 2 1 0.500 0.333 HP:0004823 hp 1 Anisopoikilocytosis 1 P27708 154 5.00e-02 61 2 1 0.500 0.016 GO:0008652 BP 1 cellular amino acid biosynthetic process 1 P27708 154 5.00e-02 29 2 1 0.500 0.034 KEGG:00250 keg 1 Alanine, aspartate and glutamate metabolism 1 P27708 154 5.00e-02 89 2 1 0.500 0.011 REAC:15869 rea 1 Metabolism of nucleotides 1 P27708 155 5.40e-04 1 2 1 0.500 1.000 GO:0098759 BP 1 cellular response to interleukin-8 1 P18146 155 5.40e-04 1 2 1 0.500 1.000 GO:2000182 BP 1 regulation of progesterone biosynthetic process 1 P18146 155 5.40e-04 1 2 1 0.500 1.000 GO:0072301 BP 1 regulation of metanephric glomerular mesangial cell proliferation 1 P18146 155 5.40e-04 1 2 1 0.500 1.000 GO:0072303 BP 1 positive regulation of glomerular metanephric mesangial cell proliferation 1 P18146 155 5.40e-04 1 2 1 0.500 1.000 GO:0098758 BP 1 response to interleukin-8 1 P18146 155 5.40e-04 1 2 1 0.500 1.000 GO:0044849 BP 1 estrous cycle 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0045362 BP 1 positive regulation of interleukin-1 biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0071506 BP 1 cellular response to mycophenolic acid 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0072126 BP 1 positive regulation of glomerular mesangial cell proliferation 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0050722 BP 1 regulation of interleukin-1 beta biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0042222 BP 1 interleukin-1 biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0071505 BP 1 response to mycophenolic acid 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0044729 MF 1 hemi-methylated DNA-binding 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0045360 BP 1 regulation of interleukin-1 biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0072262 BP 1 metanephric glomerular mesangial cell proliferation involved in metanephros development 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0050720 BP 1 interleukin-1 beta biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0006701 BP 1 progesterone biosynthetic process 1 P18146 155 1.08e-03 2 2 1 0.500 0.500 GO:0050725 BP 1 positive regulation of interleukin-1 beta biosynthetic process 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:0072223 BP 1 metanephric glomerular mesangium development 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:0071504 BP 1 cellular response to heparin 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:0071503 BP 1 response to heparin 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:0072300 BP 1 positive regulation of metanephric glomerulus development 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:1901724 BP 1 positive regulation of cell proliferation involved in kidney development 1 P18146 155 1.62e-03 3 2 1 0.500 0.333 GO:0072298 BP 1 regulation of metanephric glomerulus development 1 P18146 155 2.16e-03 4 2 1 0.500 0.250 GO:0072203 BP 1 cell proliferation involved in metanephros development 1 P18146 155 2.16e-03 4 2 1 0.500 0.250 GO:0072239 BP 1 metanephric glomerulus vasculature development 1 P18146 155 2.16e-03 4 2 1 0.500 0.250 GO:0046886 BP 1 positive regulation of hormone biosynthetic process 1 P18146 155 2.16e-03 4 2 1 0.500 0.250 GO:0010385 MF 1 double-stranded methylated DNA binding 1 P18146 155 2.16e-03 4 2 1 0.500 0.250 GO:0072124 BP 1 regulation of glomerular mesangial cell proliferation 1 P18146 155 2.70e-03 5 2 1 0.500 0.200 GO:0010566 BP 1 regulation of ketone biosynthetic process 1 P18146 155 2.70e-03 5 2 1 0.500 0.200 GO:0072110 BP 1 glomerular mesangial cell proliferation 1 P18146 155 2.70e-03 5 2 1 0.500 0.200 GO:0045080 BP 1 positive regulation of chemokine biosynthetic process 1 P18146 155 2.70e-03 5 2 1 0.500 0.200 GO:0032352 BP 1 positive regulation of hormone metabolic process 1 P18146 155 2.70e-03 5 2 1 0.500 0.200 GO:0090193 BP 1 positive regulation of glomerulus development 1 P18146 155 3.24e-03 6 2 1 0.500 0.167 GO:1901722 BP 1 regulation of cell proliferation involved in kidney development 1 P18146 155 3.24e-03 6 2 1 0.500 0.167 GO:0045073 BP 1 regulation of chemokine biosynthetic process 1 P18146 155 3.24e-03 6 2 1 0.500 0.167 GO:0072109 BP 1 glomerular mesangium development 1 P18146 155 3.24e-03 6 2 1 0.500 0.167 GO:0042448 BP 1 progesterone metabolic process 1 P18146 155 3.24e-03 6 2 1 0.500 0.167 GO:0072224 BP 1 metanephric glomerulus development 1 P18146 155 3.78e-03 7 2 1 0.500 0.143 GO:0090192 BP 1 regulation of glomerulus development 1 P18146 155 3.78e-03 7 2 1 0.500 0.143 GO:0042033 BP 1 chemokine biosynthetic process 1 P18146 155 3.78e-03 7 2 1 0.500 0.143 GO:0046885 BP 1 regulation of hormone biosynthetic process 1 P18146 155 3.78e-03 7 2 1 0.500 0.143 GO:0050755 BP 1 chemokine metabolic process 1 P18146 155 4.86e-03 9 2 1 0.500 0.111 GO:0072012 BP 1 glomerulus vasculature development 1 P18146 155 4.86e-03 9 2 1 0.500 0.111 GO:0072216 BP 1 positive regulation of metanephros development 1 P18146 155 4.86e-03 9 2 1 0.500 0.111 GO:0072111 BP 1 cell proliferation involved in kidney development 1 P18146 155 5.40e-03 10 2 1 0.500 0.100 GO:0072215 BP 1 regulation of metanephros development 1 P18146 155 5.40e-03 10 2 1 0.500 0.100 GO:0061440 BP 1 kidney vasculature development 1 P18146 155 5.40e-03 10 2 1 0.500 0.100 GO:0061437 BP 1 renal system vasculature development 1 P18146 155 5.94e-03 11 2 1 0.500 0.091 GO:0070498 BP 1 interleukin-1-mediated signaling pathway 1 P18146 155 5.94e-03 11 2 1 0.500 0.091 GO:0002931 BP 1 response to ischemia 1 P18146 155 5.94e-03 11 2 1 0.500 0.091 GO:0006700 BP 1 C21-steroid hormone biosynthetic process 1 P18146 155 5.94e-03 11 2 1 0.500 0.091 GO:0032350 BP 1 regulation of hormone metabolic process 1 P18146 155 6.47e-03 12 2 1 0.500 0.083 GO:1990841 MF 1 promoter-specific chromatin binding 1 P18146 155 6.47e-03 12 2 1 0.500 0.083 GO:0072210 BP 1 metanephric nephron development 1 P18146 155 8.09e-03 15 2 1 0.500 0.067 GO:0042181 BP 1 ketone biosynthetic process 1 P18146 155 8.63e-03 16 2 1 0.500 0.062 GO:0033233 BP 1 regulation of protein sumoylation 1 P18146 155 9.17e-03 17 2 1 0.500 0.059 GO:0032731 BP 1 positive regulation of interleukin-1 beta production 1 P18146 155 9.17e-03 17 2 1 0.500 0.059 GO:0090184 BP 1 positive regulation of kidney development 1 P18146 155 9.17e-03 17 2 1 0.500 0.059 GO:0008207 BP 1 C21-steroid hormone metabolic process 1 P18146 155 9.71e-03 18 2 1 0.500 0.056 GO:0035035 MF 1 histone acetyltransferase binding 1 P18146 155 1.02e-02 19 2 1 0.500 0.053 GO:0032732 BP 1 positive regulation of interleukin-1 production 1 P18146 155 1.08e-02 20 2 1 0.500 0.050 GO:0042108 BP 1 positive regulation of cytokine biosynthetic process 1 P18146 155 1.08e-02 20 2 1 0.500 0.050 GO:0042698 BP 1 ovulation cycle 1 P18146 155 1.13e-02 21 2 1 0.500 0.048 GO:0050810 BP 1 regulation of steroid biosynthetic process 1 P18146 155 1.19e-02 22 2 1 0.500 0.045 GO:0090183 BP 1 regulation of kidney development 1 P18146 155 1.19e-02 22 2 1 0.500 0.045 GO:0032651 BP 1 regulation of interleukin-1 beta production 1 P18146 155 1.24e-02 23 2 1 0.500 0.043 GO:0032722 BP 1 positive regulation of chemokine production 1 P18146 155 1.40e-02 26 2 1 0.500 0.038 GO:0001656 BP 1 metanephros development 1 P18146 155 1.40e-02 26 2 1 0.500 0.038 GO:0032652 BP 1 regulation of interleukin-1 production 1 P18146 155 1.46e-02 27 2 1 0.500 0.037 GO:0032611 BP 1 interleukin-1 beta production 1 P18146 155 1.46e-02 27 2 1 0.500 0.037 GO:0042446 BP 1 hormone biosynthetic process 1 P18146 155 1.62e-02 30 2 1 0.500 0.033 GO:0071347 BP 1 cellular response to interleukin-1 1 P18146 155 1.62e-02 30 2 1 0.500 0.033 GO:0032835 BP 1 glomerulus development 1 P18146 155 1.67e-02 1 2 1 0.500 1.000 TF:M01007_1 tf 1 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN; match class: 1 1 P18146 155 1.67e-02 31 2 1 0.500 0.032 GO:0032612 BP 1 interleukin-1 production 1 P18146 155 1.67e-02 31 2 1 0.500 0.032 GO:0032642 BP 1 regulation of chemokine production 1 P18146 155 1.83e-02 34 2 1 0.500 0.029 GO:0019218 BP 1 regulation of steroid metabolic process 1 P18146 155 1.89e-02 35 2 1 0.500 0.029 GO:0032602 BP 1 chemokine production 1 P18146 155 1.94e-02 36 2 1 0.500 0.028 GO:0042035 BP 1 regulation of cytokine biosynthetic process 1 P18146 155 2.10e-02 39 2 1 0.500 0.026 GO:0042107 BP 1 cytokine metabolic process 1 P18146 155 2.10e-02 39 2 1 0.500 0.026 GO:0042089 BP 1 cytokine biosynthetic process 1 P18146 155 2.26e-02 42 2 1 0.500 0.024 GO:0070555 BP 1 response to interleukin-1 1 P18146 155 2.53e-02 47 2 1 0.500 0.021 GO:0034754 BP 1 cellular hormone metabolic process 1 P18146 155 2.64e-02 49 2 1 0.500 0.020 GO:0060337 BP 1 type I interferon signaling pathway 1 P18146 155 2.64e-02 49 2 1 0.500 0.020 GO:0071357 BP 1 cellular response to type I interferon 1 P18146 155 2.75e-02 51 2 1 0.500 0.020 GO:0072006 BP 1 nephron development 1 P18146 155 2.80e-02 52 2 1 0.500 0.019 GO:0034340 BP 1 response to type I interferon 1 P18146 155 3.28e-02 61 2 1 0.500 0.016 GO:1904018 BP 1 positive regulation of vasculature development 1 P18146 155 3.45e-02 64 2 1 0.500 0.016 GO:0061448 BP 1 connective tissue development 1 P18146 155 3.66e-02 68 2 1 0.500 0.015 GO:0046890 BP 1 regulation of lipid biosynthetic process 1 P18146 155 3.76e-02 205 2 1 0.500 0.005 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 P18146 155 3.98e-02 74 2 1 0.500 0.014 GO:0071229 BP 1 cellular response to acid chemical 1 P18146 155 4.04e-02 75 2 1 0.500 0.013 GO:0006694 BP 1 steroid biosynthetic process 1 P18146 155 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 P18146 155 4.30e-02 80 2 1 0.500 0.013 GO:0042445 BP 1 hormone metabolic process 1 P18146 155 4.63e-02 86 2 1 0.500 0.012 GO:0001822 BP 1 kidney development 1 P18146 155 5.00e-02 93 2 1 0.500 0.011 GO:0001101 BP 1 response to acid chemical 1 P18146 155 5.00e-02 3 2 1 0.500 0.333 TF:M04025_1 tf 1 Factor: SRF; motif: TGMCCATATATGGKCA; match class: 1 1 P18146 155 5.00e-02 3 2 1 0.500 0.333 TF:M04025_0 tf 1 Factor: SRF; motif: TGMCCATATATGGKCA; match class: 0 1 P18146 155 5.00e-02 22 2 1 0.500 0.045 KEGG:05020 keg 1 Prion diseases 1 P18146 155 5.00e-02 93 2 1 0.500 0.011 GO:0072001 BP 1 renal system development 1 P18146 155 5.00e-02 2 2 1 0.500 0.500 CORUM:5375 cor 1 EGR-EP300 complex 1 P18146 155 5.00e-02 39 2 1 0.500 0.026 REAC:909733 rea 1 Interferon alpha/beta signaling 1 P18146 156 6.75e-03 1046 2 2 1.000 0.002 TF:M00262_0 tf 1 Factor: Staf; motif: NTTWCCCANMATGCAYYRCGNY; match class: 0 1 Q13615,Q9NRX1 156 8.29e-03 1159 2 2 1.000 0.002 TF:M01588_0 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 0 1 Q13615,Q9NRX1 156 9.56e-03 61 2 1 0.500 0.016 TF:M06332_0 tf 1 Factor: ZNF585A; motif: CACCTGGCTAAC; match class: 0 1 Q13615 156 1.05e-02 67 2 1 0.500 0.015 TF:M00979_0 tf 1 Factor: Pax-6; motif: CTGACCTGGAACTM; match class: 0 1 Q13615 156 1.08e-02 69 2 1 0.500 0.014 TF:M06089_0 tf 1 Factor: ZNF26; motif: NAMTCAAGSGTA; match class: 0 1 Q13615 156 1.13e-02 72 2 1 0.500 0.014 TF:M07343_1 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 1 1 Q13615 156 1.35e-02 86 2 1 0.500 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 Q13615 156 1.53e-02 98 2 1 0.500 0.010 TF:M06868_0 tf 1 Factor: ZNF611; motif: NGCATTGGCAGA; match class: 0 1 Q9NRX1 156 1.69e-02 108 2 1 0.500 0.009 TF:M07049_1 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 1 1 Q13615 156 2.03e-02 130 2 1 0.500 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 Q13615 156 2.31e-02 148 2 1 0.500 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 Q13615 156 2.70e-02 173 2 1 0.500 0.006 TF:M01305_0 tf 1 Factor: TEF; motif: YACATTCCWSNG; match class: 0 1 Q9NRX1 156 3.24e-02 208 2 1 0.500 0.005 TF:M06154_0 tf 1 Factor: ZNF132; motif: NTTRGAAATGTTYM; match class: 0 1 Q9NRX1 156 3.34e-02 44 2 1 0.500 0.023 REAC:1660499 rea 1 Synthesis of PIPs at the plasma membrane 1 Q13615 156 3.60e-02 231 2 1 0.500 0.004 TF:M07310_0 tf 1 Factor: Sp5; motif: ACCSCGCCKCCSS; match class: 0 1 Q13615 156 4.27e-02 2630 2 2 1.000 0.001 TF:M03574_0 tf 1 Factor: GCMa; motif: CCCGCAT; match class: 0 1 Q13615,Q9NRX1 156 4.31e-02 277 2 1 0.500 0.004 TF:M05916_0 tf 1 Factor: ZNF407; motif: NGGTGAAARARC; match class: 0 1 Q9NRX1 156 4.49e-02 289 2 1 0.500 0.003 TF:M05950_0 tf 1 Factor: ZNF700; motif: NSGWGTARTTCS; match class: 0 1 Q9NRX1 156 4.51e-02 290 2 1 0.500 0.003 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 Q9NRX1 156 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q9NRX1 156 4.67e-02 301 2 1 0.500 0.003 TF:M06188_0 tf 1 Factor: ZNF135; motif: NGTGGCTAMCGC; match class: 0 1 Q9NRX1 156 4.74e-02 305 2 1 0.500 0.003 TF:M03945_0 tf 1 Factor: CENPB; motif: CCCGCNTNNNRCGAA; match class: 0 1 Q13615 156 4.77e-02 307 2 1 0.500 0.003 TF:M06527_0 tf 1 Factor: ZNF675; motif: TGAAAGGGGA; match class: 0 1 Q13615 156 5.00e-02 66 2 1 0.500 0.015 KEGG:00562 keg 1 Inositol phosphate metabolism 1 Q13615 156 5.00e-02 66 2 1 0.500 0.015 REAC:1632852 rea 1 Macroautophagy 1 Q13615 156 5.00e-02 2 2 1 0.500 0.500 GO:1904562 BP 1 phosphatidylinositol 5-phosphate metabolic process 1 Q13615 157 4.99e-14 22 5 5 1.000 0.227 GO:0046540 CC 1 U4/U6 x U5 tri-snRNP complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.53e-13 27 5 5 1.000 0.185 GO:0097526 CC 1 spliceosomal tri-snRNP complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 5.28e-13 34 5 5 1.000 0.147 GO:0015030 CC 1 Cajal body 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 6.00e-12 54 5 5 1.000 0.093 GO:0097525 CC 1 spliceosomal snRNP complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.13e-11 61 5 5 1.000 0.082 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.26e-09 5 5 3 0.600 0.600 GO:0030621 MF 1 U4 snRNA binding 1 Q15020,Q8WWY3,O43172 157 1.28e-09 36 5 4 0.800 0.111 GO:0000387 BP 1 spliceosomal snRNP assembly 1 Q15020,Q8WWY3,O43395,O43290 157 2.74e-09 179 5 5 1.000 0.028 GO:0016604 CC 1 nuclear body 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.99e-08 265 5 5 1.000 0.019 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.99e-08 265 5 5 1.000 0.019 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.14e-08 269 5 5 1.000 0.019 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.77e-08 12 5 3 0.600 0.250 GO:0000244 BP 1 spliceosomal tri-snRNP complex assembly 1 Q15020,Q8WWY3,O43395 157 5.64e-08 326 5 5 1.000 0.015 GO:0008380 BP 1 RNA splicing 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 7.18e-08 342 5 5 1.000 0.015 GO:0006397 BP 1 mRNA processing 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 4.04e-07 147 5 4 0.800 0.027 GO:0005681 CC 1 spliceosomal complex 1 Q8WWY3,O43395,O43172,O43290 157 5.65e-07 31 5 3 0.600 0.097 GO:0017069 MF 1 snRNA binding 1 Q15020,Q8WWY3,O43172 157 5.95e-07 521 5 5 1.000 0.010 GO:0044451 CC 1 nucleoplasm part 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 6.01e-07 522 5 5 1.000 0.010 GO:0016071 BP 1 mRNA metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 7.79e-07 173 5 4 0.800 0.023 GO:0022618 BP 1 ribonucleoprotein complex assembly 1 Q15020,Q8WWY3,O43395,O43290 157 9.55e-07 182 5 4 0.800 0.022 GO:0071826 BP 1 ribonucleoprotein complex subunit organization 1 Q15020,Q8WWY3,O43395,O43290 157 1.20e-06 599 5 5 1.000 0.008 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.21e-06 600 5 5 1.000 0.008 GO:1990904 CC 1 ribonucleoprotein complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.45e-06 3 5 2 0.400 0.667 GO:0071001 CC 1 U4/U6 snRNP 1 Q15020,O43172 157 3.75e-06 752 5 5 1.000 0.007 GO:0006396 BP 1 RNA processing 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.05e-05 173 5 4 0.800 0.023 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 Q8WWY3,O43395,O43172,O43290 157 1.23e-05 180 5 4 0.800 0.022 REAC:72172 rea 1 mRNA Splicing 1 Q8WWY3,O43395,O43172,O43290 157 2.10e-05 394 5 4 0.800 0.010 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 Q15020,Q8WWY3,O43395,O43290 157 2.18e-05 10 5 2 0.400 0.200 GO:0017070 MF 1 U6 snRNA binding 1 Q15020,O43172 157 3.17e-05 228 5 4 0.800 0.018 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q8WWY3,O43395,O43172,O43290 157 6.67e-05 1336 5 5 1.000 0.004 GO:0003723 MF 1 RNA binding 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.22e-05 48 5 3 0.600 0.062 HP:0007987 hp 1 Progressive visual field defects 1 Q8WWY3,O43395,O43172 157 9.22e-05 48 5 3 0.600 0.062 HP:0200070 hp 1 Peripheral retinal atrophy 1 Q8WWY3,O43395,O43172 157 9.22e-05 48 5 3 0.600 0.062 HP:0008028 hp 1 Cystoid macular degeneration 1 Q8WWY3,O43395,O43172 157 9.22e-05 48 5 3 0.600 0.062 HP:0007830 hp 1 Adult-onset night blindness 1 Q8WWY3,O43395,O43172 157 9.81e-05 49 5 3 0.600 0.061 HP:0007950 hp 1 Peripapillary chorioretinal atrophy 1 Q8WWY3,O43395,O43172 157 1.04e-04 50 5 3 0.600 0.060 HP:0011519 hp 1 Anomalous trichromacy 1 Q8WWY3,O43395,O43172 157 1.04e-04 50 5 3 0.600 0.060 HP:0011505 hp 1 Cystoid macular edema 1 Q8WWY3,O43395,O43172 157 1.04e-04 50 5 3 0.600 0.060 HP:0000552 hp 1 Tritanomaly 1 Q8WWY3,O43395,O43172 157 1.11e-04 51 5 3 0.600 0.059 HP:0007722 hp 1 Retinal pigment epithelial atrophy 1 Q8WWY3,O43395,O43172 157 1.11e-04 51 5 3 0.600 0.059 HP:0000642 hp 1 Red-green dyschromatopsia 1 Q8WWY3,O43395,O43172 157 1.11e-04 51 5 3 0.600 0.059 HP:0040049 hp 1 Macular edema 1 Q8WWY3,O43395,O43172 157 1.18e-04 52 5 3 0.600 0.058 HP:0008020 hp 1 Progressive cone degeneration 1 Q8WWY3,O43395,O43172 157 1.18e-04 52 5 3 0.600 0.058 HP:0030498 hp 1 Macular thickening 1 Q8WWY3,O43395,O43172 157 1.24e-04 53 5 3 0.600 0.057 HP:0001146 hp 1 Pigmentary retinal degeneration 1 Q8WWY3,O43395,O43172 157 1.32e-04 54 5 3 0.600 0.056 HP:0007737 hp 1 Bone spicule pigmentation of the retina 1 Q8WWY3,O43395,O43172 157 1.47e-04 56 5 3 0.600 0.054 HP:0001099 hp 1 Fundus atrophy 1 Q8WWY3,O43395,O43172 157 1.64e-04 58 5 3 0.600 0.052 HP:0007787 hp 1 Posterior subcapsular cataract 1 Q8WWY3,O43395,O43172 157 1.64e-04 58 5 3 0.600 0.052 HP:0002527 hp 1 Falls 1 Q8WWY3,O43395,O43172 157 1.72e-04 59 5 3 0.600 0.051 HP:0000622 hp 1 Blurred vision 1 Q8WWY3,O43395,O43172 157 1.72e-04 59 5 3 0.600 0.051 HP:0007641 hp 1 Dyschromatopsia 1 Q8WWY3,O43395,O43172 157 1.81e-04 60 5 3 0.600 0.050 HP:0008043 hp 1 Retinal arteriolar constriction 1 Q8WWY3,O43395,O43172 157 1.81e-04 60 5 3 0.600 0.050 HP:0007994 hp 1 Peripheral visual field loss 1 Q8WWY3,O43395,O43172 157 1.81e-04 60 5 3 0.600 0.050 HP:0001115 hp 1 Posterior polar cataract 1 Q8WWY3,O43395,O43172 157 1.81e-04 60 5 3 0.600 0.050 HP:0007894 hp 1 Hypopigmentation of the fundus 1 Q8WWY3,O43395,O43172 157 1.94e-04 689 5 4 0.800 0.006 GO:0034622 BP 1 cellular macromolecular complex assembly 1 Q15020,Q8WWY3,O43395,O43290 157 2.10e-04 63 5 3 0.600 0.048 HP:0012045 hp 1 Retinal flecks 1 Q8WWY3,O43395,O43172 157 2.20e-04 64 5 3 0.600 0.047 HP:0001105 hp 1 Retinal atrophy 1 Q8WWY3,O43395,O43172 157 2.31e-04 65 5 3 0.600 0.046 HP:0000523 hp 1 Subcapsular cataract 1 Q8WWY3,O43395,O43172 157 2.41e-04 66 5 3 0.600 0.045 HP:0007688 hp 1 Undetectable light- and dark-adapted electroretinogram 1 Q8WWY3,O43395,O43172 157 2.41e-04 66 5 3 0.600 0.045 HP:0007843 hp 1 Attenuation of retinal blood vessels 1 Q8WWY3,O43395,O43172 157 2.41e-04 66 5 3 0.600 0.045 HP:0000603 hp 1 Central scotoma 1 Q8WWY3,O43395,O43172 157 2.53e-04 67 5 3 0.600 0.045 HP:0040215 hp 1 Abnormal circulating insulin level 1 Q8WWY3,O43395,O43172 157 2.53e-04 67 5 3 0.600 0.045 HP:0000842 hp 1 Hyperinsulinemia 1 Q8WWY3,O43395,O43172 157 2.53e-04 67 5 3 0.600 0.045 HP:0040214 hp 1 Abnormal insulin level 1 Q8WWY3,O43395,O43172 157 2.88e-04 70 5 3 0.600 0.043 HP:0000533 hp 1 Chorioretinal atrophy 1 Q8WWY3,O43395,O43172 157 2.88e-04 70 5 3 0.600 0.043 HP:0007875 hp 1 Congenital blindness 1 Q8WWY3,O43395,O43172 157 3.01e-04 71 5 3 0.600 0.042 HP:0200065 hp 1 Chorioretinal degeneration 1 Q8WWY3,O43395,O43172 157 3.14e-04 72 5 3 0.600 0.042 HP:0001133 hp 1 Constriction of peripheral visual field 1 Q8WWY3,O43395,O43172 157 3.27e-04 73 5 3 0.600 0.041 HP:0030506 hp 1 Yellow/white lesions of the retina 1 Q8WWY3,O43395,O43172 157 3.27e-04 73 5 3 0.600 0.041 HP:0012263 hp 1 Immotile cilia 1 Q8WWY3,O43395,O43172 157 3.40e-04 74 5 3 0.600 0.041 HP:0012043 hp 1 Pendular nystagmus 1 Q8WWY3,O43395,O43172 157 3.40e-04 74 5 3 0.600 0.041 HP:0012261 hp 1 Abnormal respiratory motile cilium physiology 1 Q8WWY3,O43395,O43172 157 3.40e-04 74 5 3 0.600 0.041 HP:0012262 hp 1 Abnormal ciliary motility 1 Q8WWY3,O43395,O43172 157 3.54e-04 75 5 3 0.600 0.040 HP:0000563 hp 1 Keratoconus 1 Q8WWY3,O43395,O43172 157 3.54e-04 75 5 3 0.600 0.040 HP:0001141 hp 1 Severe visual impairment 1 Q8WWY3,O43395,O43172 157 3.54e-04 75 5 3 0.600 0.040 HP:0100692 hp 1 Increased corneal curvature 1 Q8WWY3,O43395,O43172 157 3.83e-04 77 5 3 0.600 0.039 HP:0100689 hp 1 Decreased corneal thickness 1 Q8WWY3,O43395,O43172 157 3.83e-04 77 5 3 0.600 0.039 HP:0007401 hp 1 Macular atrophy 1 Q8WWY3,O43395,O43172 157 3.83e-04 77 5 3 0.600 0.039 HP:0000575 hp 1 Scotoma 1 Q8WWY3,O43395,O43172 157 4.14e-04 79 5 3 0.600 0.038 HP:0011486 hp 1 Abnormality of corneal thickness 1 Q8WWY3,O43395,O43172 157 4.46e-04 81 5 3 0.600 0.037 HP:0000654 hp 1 Decreased light- and dark-adapted electroretinogram amplitude 1 Q8WWY3,O43395,O43172 157 4.80e-04 83 5 3 0.600 0.036 HP:0010696 hp 1 Polar cataract 1 Q8WWY3,O43395,O43172 157 4.80e-04 83 5 3 0.600 0.036 HP:0000630 hp 1 Abnormality of retinal arteries 1 Q8WWY3,O43395,O43172 157 5.15e-04 85 5 3 0.600 0.035 HP:3000036 hp 1 Abnormality of head blood vessel 1 Q8WWY3,O43395,O43172 157 5.34e-04 86 5 3 0.600 0.035 HP:0000548 hp 1 Cone/cone-rod dystrophy 1 Q8WWY3,O43395,O43172 157 5.72e-04 88 5 3 0.600 0.034 HP:0005978 hp 1 Type II diabetes mellitus 1 Q8WWY3,O43395,O43172 157 6.11e-04 90 5 3 0.600 0.033 HP:0008323 hp 1 Abnormal light- and dark-adapted electroretinogram 1 Q8WWY3,O43395,O43172 157 6.32e-04 91 5 3 0.600 0.033 HP:0000987 hp 1 Atypical scarring of skin 1 Q8WWY3,O43395,O43172 157 6.53e-04 92 5 3 0.600 0.033 HP:0000529 hp 1 Progressive visual loss 1 Q8WWY3,O43395,O43172 157 6.53e-04 92 5 3 0.600 0.033 HP:0030466 hp 1 Abnormal full-field electroretinogram 1 Q8WWY3,O43395,O43172 157 6.74e-04 93 5 3 0.600 0.032 HP:0000551 hp 1 Abnormality of color vision 1 Q8WWY3,O43395,O43172 157 6.74e-04 93 5 3 0.600 0.032 HP:0030637 hp 1 Cone dysfunction 1 Q8WWY3,O43395,O43172 157 6.99e-04 2136 5 5 1.000 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 7.64e-04 97 5 3 0.600 0.031 HP:0000550 hp 1 Undetectable electroretinogram 1 Q8WWY3,O43395,O43172 157 7.88e-04 98 5 3 0.600 0.031 HP:0000608 hp 1 Macular degeneration 1 Q8WWY3,O43395,O43172 157 1.05e-03 108 5 3 0.600 0.028 HP:0100699 hp 1 Scarring 1 Q8WWY3,O43395,O43172 157 1.27e-03 115 5 3 0.600 0.026 HP:0001123 hp 1 Visual field defect 1 Q8WWY3,O43395,O43172 157 1.28e-03 1113 5 4 0.800 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 Q15020,Q8WWY3,O43395,O43290 157 1.31e-03 1118 5 4 0.800 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 Q15020,Q8WWY3,O43395,O43290 157 1.33e-03 117 5 3 0.600 0.026 HP:0000980 hp 1 Pallor 1 Q8WWY3,O43395,O43172 157 1.40e-03 1 5 1 0.200 1.000 GO:0005691 CC 1 U6atac snRNP 1 Q15020 157 1.40e-03 1 5 1 0.200 1.000 GO:0070990 MF 1 snRNP binding 1 Q8WWY3 157 1.40e-03 1 5 1 0.200 1.000 GO:0071002 CC 1 U4atac/U6atac snRNP 1 Q15020 157 1.40e-03 1 5 1 0.200 1.000 GO:1903584 BP 1 regulation of histone deubiquitination 1 Q15020 157 1.40e-03 1 5 1 0.200 1.000 GO:0030624 MF 1 U6atac snRNA binding 1 Q15020 157 1.40e-03 1 5 1 0.200 1.000 GO:0000481 BP 1 maturation of 5S rRNA 1 O43290 157 1.40e-03 1 5 1 0.200 1.000 GO:0005690 CC 1 U4atac snRNP 1 Q8WWY3 157 1.40e-03 1 5 1 0.200 1.000 GO:1903586 BP 1 positive regulation of histone deubiquitination 1 Q15020 157 1.51e-03 80 5 2 0.400 0.025 GO:0016607 CC 1 nuclear speck 1 Q8WWY3,O43172 157 1.55e-03 123 5 3 0.600 0.024 HP:0000541 hp 1 Retinal detachment 1 Q8WWY3,O43395,O43172 157 1.63e-03 2529 5 5 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.66e-03 126 5 3 0.600 0.024 HP:0000613 hp 1 Photophobia 1 Q8WWY3,O43395,O43172 157 1.78e-03 129 5 3 0.600 0.023 HP:0001696 hp 1 Situs inversus totalis 1 Q8WWY3,O43395,O43172 157 1.78e-03 129 5 3 0.600 0.023 HP:0011534 hp 1 Abnormal spatial orientation of the cardiac segments 1 Q8WWY3,O43395,O43172 157 1.82e-03 130 5 3 0.600 0.023 HP:0008046 hp 1 Abnormality of the retinal vasculature 1 Q8WWY3,O43395,O43172 157 1.82e-03 130 5 3 0.600 0.023 HP:0000483 hp 1 Astigmatism 1 Q8WWY3,O43395,O43172 157 1.86e-03 131 5 3 0.600 0.023 HP:0000543 hp 1 Optic disc pallor 1 Q8WWY3,O43395,O43172 157 1.91e-03 2612 5 5 1.000 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.97e-03 2627 5 5 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.03e-03 135 5 3 0.600 0.022 HP:0001651 hp 1 Dextrocardia 1 Q8WWY3,O43395,O43172 157 2.08e-03 136 5 3 0.600 0.022 HP:0004307 hp 1 Abnormal anatomic location of the heart 1 Q8WWY3,O43395,O43172 157 2.10e-03 2660 5 5 1.000 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.22e-03 139 5 3 0.600 0.022 HP:0008047 hp 1 Abnormality of the vasculature of the eye 1 Q8WWY3,O43395,O43172 157 2.36e-03 6 5 1 0.200 0.167 TF:M06897_0 tf 1 Factor: ZNF789; motif: NGGGTTTGCARC; match class: 0 1 Q15020 157 2.61e-03 147 5 3 0.600 0.020 HP:0003829 hp 1 Incomplete penetrance 1 Q8WWY3,O43395,O43172 157 2.75e-03 7 5 1 0.200 0.143 TF:M05874_1 tf 1 Factor: ZNF564; motif: KGGWHGTGAACM; match class: 1 1 O43290 157 2.77e-03 150 5 3 0.600 0.020 HP:0000540 hp 1 Hypermetropia 1 Q8WWY3,O43395,O43172 157 2.78e-03 564 5 3 0.600 0.005 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 2.79e-03 2 5 1 0.200 0.500 GO:0045583 BP 1 regulation of cytotoxic T cell differentiation 1 O43290 157 2.79e-03 2 5 1 0.200 0.500 GO:0030622 MF 1 U4atac snRNA binding 1 Q8WWY3 157 2.79e-03 2 5 1 0.200 0.500 GO:0045585 BP 1 positive regulation of cytotoxic T cell differentiation 1 O43290 157 2.79e-03 2 5 1 0.200 0.500 GO:0045065 BP 1 cytotoxic T cell differentiation 1 O43290 157 3.17e-03 157 5 3 0.600 0.019 HP:0001103 hp 1 Abnormality of the macula 1 Q8WWY3,O43395,O43172 157 3.35e-03 160 5 3 0.600 0.019 HP:0100691 hp 1 Abnormality of the curvature of the cornea 1 Q8WWY3,O43395,O43172 157 3.41e-03 2931 5 5 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 3.66e-03 219 5 2 0.400 0.009 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 Q8WWY3,O43395 157 3.86e-03 168 5 3 0.600 0.018 HP:0003117 hp 1 Abnormality of circulating hormone level 1 Q8WWY3,O43395,O43172 157 3.86e-03 168 5 3 0.600 0.018 HP:0000662 hp 1 Nyctalopia 1 Q8WWY3,O43395,O43172 157 3.86e-03 168 5 3 0.600 0.018 HP:0000532 hp 1 Chorioretinal abnormality 1 Q8WWY3,O43395,O43172 157 3.91e-03 3013 5 5 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 3.93e-03 169 5 3 0.600 0.018 HP:0100259 hp 1 Postaxial polydactyly 1 Q8WWY3,O43395,O43172 157 4.00e-03 170 5 3 0.600 0.018 HP:0000546 hp 1 Retinal degeneration 1 Q8WWY3,O43395,O43172 157 4.07e-03 171 5 3 0.600 0.018 HP:0000572 hp 1 Visual loss 1 Q8WWY3,O43395,O43172 157 4.21e-03 173 5 3 0.600 0.017 HP:0007663 hp 1 Reduced visual acuity 1 Q8WWY3,O43395,O43172 157 4.21e-03 3058 5 5 1.000 0.002 GO:0010467 BP 1 gene expression 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 4.28e-03 174 5 3 0.600 0.017 HP:0000512 hp 1 Abnormal electroretinogram 1 Q8WWY3,O43395,O43172 157 4.50e-03 160 5 2 0.400 0.013 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 Q8WWY3,O43172 157 4.57e-03 178 5 3 0.600 0.017 HP:0000597 hp 1 Ophthalmoparesis 1 Q8WWY3,O43395,O43172 157 4.65e-03 179 5 3 0.600 0.017 HP:0000610 hp 1 Abnormality of the choroid 1 Q8WWY3,O43395,O43172 157 4.71e-03 12 5 1 0.200 0.083 TF:M06228_0 tf 1 Factor: ZNF543; motif: KGGWATRTGGGA; match class: 0 1 O43290 157 5.03e-03 3168 5 5 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 5.11e-03 185 5 3 0.600 0.016 HP:0000618 hp 1 Blindness 1 Q8WWY3,O43395,O43172 157 5.28e-03 187 5 3 0.600 0.016 HP:0000510 hp 1 Rod-cone dystrophy 1 Q8WWY3,O43395,O43172 157 5.45e-03 1087 5 3 0.600 0.003 TF:M00178_0 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 0 1 Q15020,O43395,O43172 157 5.47e-03 1614 5 4 0.800 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q15020,Q8WWY3,O43395,O43290 157 5.59e-03 4 5 1 0.200 0.250 GO:1903003 BP 1 positive regulation of protein deubiquitination 1 Q15020 157 5.96e-03 733 5 3 0.600 0.004 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 6.27e-03 16 5 1 0.200 0.062 TF:M06270_0 tf 1 Factor: ZNF468; motif: KGGGGGWGCGGA; match class: 0 1 O43395 157 6.41e-03 200 5 3 0.600 0.015 HP:0000819 hp 1 Diabetes mellitus 1 Q8WWY3,O43395,O43172 157 6.78e-03 1706 5 4 0.800 0.002 GO:0022607 BP 1 cellular component assembly 1 Q15020,Q8WWY3,O43395,O43290 157 6.79e-03 204 5 3 0.600 0.015 HP:0030453 hp 1 Abnormal visual electrophysiology 1 Q8WWY3,O43395,O43172 157 6.98e-03 5 5 1 0.200 0.200 GO:0048254 BP 1 snoRNA localization 1 Q8WWY3 157 7.15e-03 1804 5 4 0.800 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172,O43290 157 7.32e-03 3415 5 5 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 7.59e-03 212 5 3 0.600 0.014 HP:0000501 hp 1 Glaucoma 1 Q8WWY3,O43395,O43172 157 7.62e-03 3443 5 5 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 7.69e-03 213 5 3 0.600 0.014 HP:0000405 hp 1 Conductive hearing impairment 1 Q8WWY3,O43395,O43172 157 7.90e-03 215 5 3 0.600 0.014 HP:0001513 hp 1 Obesity 1 Q8WWY3,O43395,O43172 157 8.25e-03 1257 5 3 0.600 0.002 TF:M00041_0 tf 1 Factor: ATF2:c-Jun; motif: TGACGTYA; match class: 0 1 Q15020,O43395,O43172 157 8.33e-03 4887 5 5 1.000 0.001 TF:M02074_0 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 0 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 8.45e-03 2705 5 4 0.800 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 8.50e-03 221 5 2 0.400 0.009 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 Q8WWY3,O43172 157 8.78e-03 223 5 3 0.600 0.013 HP:0004324 hp 1 Increased body weight 1 Q8WWY3,O43395,O43172 157 8.93e-03 3554 5 5 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.01e-03 225 5 3 0.600 0.013 HP:0001419 hp 1 X-linked recessive inheritance 1 Q8WWY3,O43395,O43172 157 9.02e-03 3561 5 5 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.02e-03 3561 5 5 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.02e-03 3561 5 5 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.02e-03 3561 5 5 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 9.52e-03 1322 5 3 0.600 0.002 TF:M00113_0 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 0 1 Q15020,Q8WWY3,O43172 157 9.98e-03 416 5 2 0.400 0.005 TF:M00222_1 tf 1 Factor: Hand1:E47; motif: NNNNGNRTCTGGMWTT; match class: 1 1 Q8WWY3,O43172 157 1.06e-02 3681 5 5 1.000 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.07e-02 239 5 3 0.600 0.013 HP:0010442 hp 1 Polydactyly 1 Q8WWY3,O43395,O43172 157 1.10e-02 1932 5 4 0.800 0.002 GO:0044085 BP 1 cellular component biogenesis 1 Q15020,Q8WWY3,O43395,O43290 157 1.10e-02 5164 5 5 1.000 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.10e-02 906 5 3 0.600 0.003 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 1.12e-02 8 5 1 0.200 0.125 GO:0090085 BP 1 regulation of protein deubiquitination 1 Q15020 157 1.14e-02 244 5 3 0.600 0.012 HP:0000556 hp 1 Retinal dystrophy 1 Q8WWY3,O43395,O43172 157 1.17e-02 1423 5 3 0.600 0.002 TF:M01862_1 tf 1 Factor: ATF-2; motif: NNNTGACGTNAN; match class: 1 1 Q15020,O43395,O43172 157 1.19e-02 248 5 3 0.600 0.012 HP:0011452 hp 1 Functional abnormality of the middle ear 1 Q8WWY3,O43395,O43172 157 1.20e-02 402 5 2 0.400 0.005 MI:hsa-miR-599 mi 1 MI:hsa-miR-599 1 Q8WWY3,O43290 157 1.21e-02 938 5 3 0.600 0.003 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 1.22e-02 407 5 2 0.400 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 Q15020,O43395 157 1.29e-02 418 5 2 0.400 0.005 MI:hsa-miR-563 mi 1 MI:hsa-miR-563 1 Q15020,O43395 157 1.32e-02 965 5 3 0.600 0.003 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 1.35e-02 5379 5 5 1.000 0.001 TF:M02071_1 tf 1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.35e-02 486 5 2 0.400 0.004 TF:M00178_1 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 1 1 Q15020,O43395 157 1.40e-02 10 5 1 0.200 0.100 GO:0005687 CC 1 U4 snRNP 1 Q8WWY3 157 1.40e-02 3093 5 4 0.800 0.001 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 1.42e-02 264 5 3 0.600 0.011 HP:0000580 hp 1 Pigmentary retinopathy 1 Q8WWY3,O43395,O43172 157 1.44e-02 995 5 3 0.600 0.003 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 Q8WWY3,O43172,O43290 157 1.47e-02 447 5 2 0.400 0.004 MI:hsa-miR-502-5p mi 1 MI:hsa-miR-502-5p 1 Q8WWY3,O43172 157 1.47e-02 267 5 3 0.600 0.011 HP:0000431 hp 1 Wide nasal bridge 1 Q8WWY3,O43395,O43172 157 1.48e-02 1547 5 3 0.600 0.002 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 Q15020,O43395,O43172 157 1.48e-02 1547 5 3 0.600 0.002 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 Q15020,O43395,O43172 157 1.51e-02 3948 5 5 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.52e-02 455 5 2 0.400 0.004 MI:mmu-miR-714 mi 1 MI:mmu-miR-714 1 Q8WWY3,O43395 157 1.52e-02 270 5 3 0.600 0.011 HP:0008736 hp 1 Hypoplasia of penis 1 Q8WWY3,O43395,O43172 157 1.58e-02 1028 5 3 0.600 0.003 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 Q15020,Q8WWY3,O43395 157 1.58e-02 465 5 2 0.400 0.004 MI:hsa-miR-886-5p mi 1 MI:hsa-miR-886-5p 1 Q15020,Q8WWY3 157 1.61e-02 5578 5 5 1.000 0.001 TF:M00801_0 tf 1 Factor: CREB; motif: CGTCAN; match class: 0 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.67e-02 12 5 1 0.200 0.083 GO:1990381 MF 1 ubiquitin-specific protease binding 1 Q15020 157 1.70e-02 1055 5 3 0.600 0.003 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 1.80e-02 1657 5 3 0.600 0.002 TF:M07312_0 tf 1 Factor: ATF-2; motif: NNTGACGTCAN; match class: 0 1 Q15020,O43395,O43172 157 1.84e-02 289 5 3 0.600 0.010 HP:0000969 hp 1 Edema 1 Q8WWY3,O43395,O43172 157 1.91e-02 513 5 2 0.400 0.004 MI:hsa-miR-20b mi 1 MI:hsa-miR-20b 1 O43172,O43290 157 1.91e-02 49 5 1 0.200 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 O43395 157 1.92e-02 585 5 2 0.400 0.003 TF:M00621_1 tf 1 Factor: C/EBPdelta; motif: MATTKCNTMAYY; match class: 1 1 Q15020,Q8WWY3 157 1.95e-02 1706 5 3 0.600 0.002 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 Q15020,O43395,O43172 157 1.97e-02 4237 5 5 1.000 0.001 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 1.98e-02 341 5 2 0.400 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 Q8WWY3,O43172 157 2.00e-02 525 5 2 0.400 0.004 MI:hsa-miR-212 mi 1 MI:hsa-miR-212 1 Q15020,O43290 157 2.03e-02 345 5 2 0.400 0.006 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 Q8WWY3,O43172 157 2.03e-02 1732 5 3 0.600 0.002 TF:M07248_1 tf 1 Factor: CREB1; motif: NNNNTGACGTNANNN; match class: 1 1 Q15020,O43395,O43172 157 2.04e-02 531 5 2 0.400 0.004 MI:hsa-miR-132 mi 1 MI:hsa-miR-132 1 Q15020,O43290 157 2.05e-02 533 5 2 0.400 0.004 MI:hsa-miR-17 mi 1 MI:hsa-miR-17 1 O43172,O43290 157 2.10e-02 54 5 1 0.200 0.019 TF:M05980_0 tf 1 Factor: zfp64; motif: NATACGGMTC; match class: 0 1 O43290 157 2.18e-02 1152 5 3 0.600 0.003 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 2.18e-02 56 5 1 0.200 0.018 TF:M03951_0 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 0 1 Q8WWY3 157 2.19e-02 307 5 3 0.600 0.010 HP:0001000 hp 1 Abnormality of skin pigmentation 1 Q8WWY3,O43395,O43172 157 2.22e-02 4264 5 5 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.23e-02 16 5 1 0.200 0.062 GO:0045292 BP 1 mRNA cis splicing, via spliceosome 1 O43290 157 2.30e-02 1175 5 3 0.600 0.003 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 2.31e-02 2454 5 4 0.800 0.002 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172,O43290 157 2.46e-02 320 5 3 0.600 0.009 HP:0000545 hp 1 Myopia 1 Q8WWY3,O43395,O43172 157 2.49e-02 384 5 2 0.400 0.005 HPA:040010_03 hpa 1 soft tissue 2; adipocytes[Uncertain,High] 1 Q8WWY3,O43172 157 2.50e-02 322 5 3 0.600 0.009 HP:0000050 hp 1 Hypoplastic male external genitalia 1 Q8WWY3,O43395,O43172 157 2.52e-02 6097 5 5 1.000 0.001 TF:M00025_1 tf 1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.57e-02 325 5 3 0.600 0.009 HP:0007703 hp 1 Abnormality of retinal pigmentation 1 Q8WWY3,O43395,O43172 157 2.58e-02 391 5 2 0.400 0.005 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 Q8WWY3,O43290 157 2.59e-02 2527 5 4 0.800 0.002 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172,O43290 157 2.65e-02 3667 5 4 0.800 0.001 TF:M00739_0 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 0 1 Q15020,Q8WWY3,O43395,O43290 157 2.66e-02 329 5 3 0.600 0.009 HP:0002205 hp 1 Recurrent respiratory infections 1 Q8WWY3,O43395,O43172 157 2.69e-02 4430 5 5 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 2.74e-02 705 5 2 0.400 0.003 TF:M07052_1 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 1 Q15020,O43290 157 2.75e-02 404 5 2 0.400 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q8WWY3,O43172 157 2.75e-02 1933 5 3 0.600 0.002 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 Q15020,Q8WWY3,O43290 157 2.77e-02 1254 5 3 0.600 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 2.78e-02 1256 5 3 0.600 0.002 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 Q8WWY3,O43172,O43290 157 2.79e-02 20 5 1 0.200 0.050 GO:0016578 BP 1 histone deubiquitination 1 Q15020 157 2.80e-02 408 5 2 0.400 0.005 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q8WWY3,O43172 157 2.81e-02 1949 5 3 0.600 0.002 TF:M02067_1 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 1 1 Q8WWY3,O43172,O43290 157 2.82e-02 2585 5 4 0.800 0.002 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172,O43290 157 2.82e-02 336 5 3 0.600 0.009 HP:0011032 hp 1 Abnormality of fluid regulation 1 Q8WWY3,O43395,O43172 157 2.82e-02 336 5 3 0.600 0.009 HP:0003241 hp 1 External genital hypoplasia 1 Q8WWY3,O43395,O43172 157 2.82e-02 336 5 3 0.600 0.009 HP:0000463 hp 1 Anteverted nares 1 Q8WWY3,O43395,O43172 157 2.87e-02 74 5 1 0.200 0.014 TF:M00215_0 tf 1 Factor: SRF; motif: DCCWTATATGGNCWN; match class: 0 1 Q8WWY3 157 2.96e-02 342 5 3 0.600 0.009 HP:0005288 hp 1 Abnormality of the nares 1 Q8WWY3,O43395,O43172 157 3.03e-02 78 5 1 0.200 0.013 TF:M07339_1 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 1 1 Q8WWY3 157 3.06e-02 346 5 3 0.600 0.009 HP:0011014 hp 1 Abnormal glucose homeostasis 1 Q8WWY3,O43395,O43172 157 3.06e-02 22 5 1 0.200 0.045 GO:0045582 BP 1 positive regulation of T cell differentiation 1 O43290 157 3.13e-02 1310 5 3 0.600 0.002 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 3.17e-02 4659 5 5 1.000 0.001 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 3.18e-02 82 5 1 0.200 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 O43395 157 3.26e-02 354 5 3 0.600 0.008 HP:0000370 hp 1 Abnormality of the middle ear 1 Q8WWY3,O43395,O43172 157 3.31e-02 2068 5 3 0.600 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 Q15020,Q8WWY3,O43290 157 3.33e-02 86 5 1 0.200 0.012 TF:M05464_1 tf 1 Factor: Sall1; motif: NAKKCGKAAAKG; match class: 1 1 Q15020 157 3.39e-02 359 5 3 0.600 0.008 HP:0000553 hp 1 Abnormality of the uvea 1 Q8WWY3,O43395,O43172 157 3.41e-02 88 5 1 0.200 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 O43172 157 3.43e-02 2096 5 3 0.600 0.001 TF:M00053_0 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 0 1 Q15020,Q8WWY3,O43290 157 3.44e-02 454 5 2 0.400 0.004 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q8WWY3,O43172 157 3.47e-02 800 5 2 0.400 0.003 TF:M01864_1 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 1 1 Q15020,O43395 157 3.48e-02 25 5 1 0.200 0.040 GO:0071011 CC 1 precatalytic spliceosome 1 Q8WWY3 157 3.61e-02 367 5 3 0.600 0.008 HP:0011947 hp 1 Respiratory tract infection 1 Q8WWY3,O43395,O43172 157 3.63e-02 3996 5 4 0.800 0.001 TF:M00917_0 tf 1 Factor: CREB; motif: CNNTGACGTMA; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 3.68e-02 4010 5 4 0.800 0.001 TF:M03544_0 tf 1 Factor: CREB1; motif: NNNNACGTCANN; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 3.74e-02 1396 5 3 0.600 0.002 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q8WWY3,O43172,O43290 157 3.76e-02 27 5 1 0.200 0.037 GO:0044665 CC 1 MLL1/2 complex 1 Q8WWY3 157 3.76e-02 27 5 1 0.200 0.037 GO:0071339 CC 1 MLL1 complex 1 Q8WWY3 157 3.79e-02 2174 5 3 0.600 0.001 TF:M04303_0 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 0 1 Q8WWY3,O43395,O43172 157 3.83e-02 1408 5 3 0.600 0.002 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 3.86e-02 2188 5 3 0.600 0.001 TF:M02279_0 tf 1 Factor: CREB1; motif: TGACGTCA; match class: 0 1 Q15020,O43395,O43172 157 3.87e-02 100 5 1 0.200 0.010 TF:M03967_0 tf 1 Factor: ELF3; motif: WACCCGGAAGTAN; match class: 0 1 O43290 157 3.89e-02 484 5 2 0.400 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q8WWY3,O43172 157 3.89e-02 28 5 1 0.200 0.036 GO:0045621 BP 1 positive regulation of lymphocyte differentiation 1 O43290 157 3.91e-02 852 5 2 0.400 0.002 TF:M00039_0 tf 1 Factor: CREB; motif: TGACGTMA; match class: 0 1 Q15020,O43395 157 3.91e-02 852 5 2 0.400 0.002 TF:M00039_1 tf 1 Factor: CREB; motif: TGACGTMA; match class: 1 1 Q15020,O43395 157 3.92e-02 486 5 2 0.400 0.004 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q8WWY3,O43172 157 3.93e-02 2204 5 3 0.600 0.001 TF:M01107_1 tf 1 Factor: RUSH-1alpha; motif: NNMCWTNKNN; match class: 1 1 Q15020,Q8WWY3,O43172 157 3.94e-02 102 5 1 0.200 0.010 TF:M04173_0 tf 1 Factor: HEY2; motif: GNCACGTGYN; match class: 0 1 O43172 157 3.94e-02 102 5 1 0.200 0.010 TF:M04172_0 tf 1 Factor: HEY1; motif: GRCACGTGCC; match class: 0 1 O43172 157 3.94e-02 102 5 1 0.200 0.010 TF:M07089_1 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 1 1 Q15020 157 3.94e-02 102 5 1 0.200 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 Q15020 157 3.97e-02 489 5 2 0.400 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q8WWY3,O43172 157 3.98e-02 860 5 2 0.400 0.002 TF:M00041_1 tf 1 Factor: ATF2:c-Jun; motif: TGACGTYA; match class: 1 1 Q15020,O43395 157 3.99e-02 2216 5 3 0.600 0.001 TF:M00740_0 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 0 1 Q15020,O43395,O43290 157 4.00e-02 381 5 3 0.600 0.008 HP:0000539 hp 1 Abnormality of refraction 1 Q8WWY3,O43395,O43172 157 4.03e-02 382 5 3 0.600 0.008 HP:0011004 hp 1 Abnormality of the systemic arterial tree 1 Q8WWY3,O43395,O43172 157 4.08e-02 1440 5 3 0.600 0.002 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 4.09e-02 384 5 3 0.600 0.008 HP:0001417 hp 1 X-linked inheritance 1 Q8WWY3,O43395,O43172 157 4.10e-02 106 5 1 0.200 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 Q8WWY3 157 4.13e-02 107 5 1 0.200 0.009 TF:M01007_0 tf 1 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN; match class: 0 1 Q8WWY3 157 4.20e-02 2875 5 4 0.800 0.001 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172,O43290 157 4.21e-02 388 5 3 0.600 0.008 HP:0010985 hp 1 Gonosomal inheritance 1 Q8WWY3,O43395,O43172 157 4.22e-02 505 5 2 0.400 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q8WWY3,O43172 157 4.25e-02 891 5 2 0.400 0.002 TF:M07312_1 tf 1 Factor: ATF-2; motif: NNTGACGTCAN; match class: 1 1 Q15020,O43395 157 4.27e-02 894 5 2 0.400 0.002 TF:M07218_0 tf 1 Factor: MEF-2A; motif: NKCTAAAAATAGMNN; match class: 0 1 Q15020,Q8WWY3 157 4.31e-02 31 5 1 0.200 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 Q8WWY3 157 4.32e-02 1470 5 3 0.600 0.002 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q8WWY3,O43172,O43290 157 4.32e-02 4190 5 4 0.800 0.001 TF:M04436_0 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 4.38e-02 4204 5 4 0.800 0.001 TF:M01862_0 tf 1 Factor: ATF-2; motif: NNNTGACGTNAN; match class: 0 1 Q15020,Q8WWY3,O43395,O43172 157 4.49e-02 2314 5 3 0.600 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 Q15020,O43395,O43290 157 4.52e-02 398 5 3 0.600 0.008 HP:0011013 hp 1 Abnormality of carbohydrate metabolism/homeostasis 1 Q8WWY3,O43395,O43172 157 4.56e-02 1499 5 3 0.600 0.002 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q8WWY3,O43172,O43290 157 4.63e-02 1508 5 3 0.600 0.002 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 4.68e-02 1513 5 3 0.600 0.002 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q8WWY3,O43172,O43290 157 4.69e-02 940 5 2 0.400 0.002 TF:M00513_1 tf 1 Factor: ATF3; motif: CBCTGACGTCANCS; match class: 1 1 Q15020,O43395 157 4.74e-02 537 5 2 0.400 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q8WWY3,O43172 157 4.75e-02 1521 5 3 0.600 0.002 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q8WWY3,O43172,O43290 157 4.77e-02 2367 5 3 0.600 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q15020,O43395,O43172 157 4.78e-02 124 5 1 0.200 0.008 TF:M05825_0 tf 1 Factor: ZNF572; motif: NGGTAGDGAAGC; match class: 0 1 O43290 157 4.78e-02 950 5 2 0.400 0.002 TF:M02279_1 tf 1 Factor: CREB1; motif: TGACGTCA; match class: 1 1 Q15020,O43395 157 4.79e-02 540 5 2 0.400 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q8WWY3,O43172 157 4.80e-02 407 5 3 0.600 0.007 HP:0000429 hp 1 Abnormality of the nasal alae 1 Q8WWY3,O43395,O43172 157 4.81e-02 541 5 2 0.400 0.004 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 Q8WWY3,O43172 157 4.84e-02 408 5 3 0.600 0.007 HP:0000648 hp 1 Optic atrophy 1 Q8WWY3,O43395,O43172 157 4.85e-02 126 5 1 0.200 0.008 TF:M03968_0 tf 1 Factor: ELF4; motif: AACCCGGAAGTR; match class: 0 1 O43290 157 4.88e-02 4990 5 5 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q15020,Q8WWY3,O43395,O43172,O43290 157 4.94e-02 549 5 2 0.400 0.004 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 Q8WWY3,O43172 157 5.00e-02 1 5 1 0.200 1.000 OMIM:615922 omi 1 RETINITIS PIGMENTOSA 70; RP70 1 O43172 157 5.00e-02 1485 5 4 0.800 0.003 REAC:74160 rea 1 Gene Expression 1 Q8WWY3,O43395,O43172,O43290 157 5.00e-02 141 5 4 0.800 0.028 CORUM:351 cor 1 Spliceosome 1 Q8WWY3,O43395,O43172,O43290 157 5.00e-02 1550 5 3 0.600 0.002 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 Q15020,Q8WWY3,O43172 157 5.00e-02 413 5 3 0.600 0.007 HP:0000036 hp 1 Abnormality of the penis 1 Q8WWY3,O43395,O43172 157 5.00e-02 1 5 1 0.200 1.000 OMIM:601414 omi 1 RETINITIS PIGMENTOSA 18; RP18 1 O43395 157 5.00e-02 36 5 1 0.200 0.028 GO:0045580 BP 1 regulation of T cell differentiation 1 O43290 157 5.00e-02 128 5 4 0.800 0.031 KEGG:03040 keg 1 Spliceosome 1 Q8WWY3,O43395,O43172,O43290 158 1.21e-06 4 3 2 0.667 0.500 GO:0038165 BP 1 oncostatin-M-mediated signaling pathway 1 P13725,P40189 158 6.29e-06 9 3 2 0.667 0.222 REAC:6788467 rea 1 IL-6-type cytokine receptor ligand interactions 1 P13725,P40189 158 1.11e-05 11 3 2 0.667 0.182 GO:0002675 BP 1 positive regulation of acute inflammatory response 1 P13725,P40189 158 1.57e-05 13 3 2 0.667 0.154 GO:0042517 BP 1 positive regulation of tyrosine phosphorylation of Stat3 protein 1 P13725,P40189 158 1.59e-05 14 3 2 0.667 0.143 REAC:6783589 rea 1 Interleukin-6 family signaling 1 P13725,P40189 158 3.08e-05 18 3 2 0.667 0.111 GO:0042516 BP 1 regulation of tyrosine phosphorylation of Stat3 protein 1 P13725,P40189 158 3.44e-05 19 3 2 0.667 0.105 GO:0042531 BP 1 positive regulation of tyrosine phosphorylation of STAT protein 1 P13725,P40189 158 3.44e-05 19 3 2 0.667 0.105 GO:0042503 BP 1 tyrosine phosphorylation of Stat3 protein 1 P13725,P40189 158 5.56e-05 24 3 2 0.667 0.083 GO:0046427 BP 1 positive regulation of JAK-STAT cascade 1 P13725,P40189 158 5.56e-05 24 3 2 0.667 0.083 GO:1904894 BP 1 positive regulation of STAT cascade 1 P13725,P40189 158 6.04e-05 25 3 2 0.667 0.080 GO:0042509 BP 1 regulation of tyrosine phosphorylation of STAT protein 1 P13725,P40189 158 7.06e-05 27 3 2 0.667 0.074 GO:0007260 BP 1 tyrosine phosphorylation of STAT protein 1 P13725,P40189 158 1.06e-04 33 3 2 0.667 0.061 GO:0002673 BP 1 regulation of acute inflammatory response 1 P13725,P40189 158 1.41e-04 38 3 2 0.667 0.053 GO:0050729 BP 1 positive regulation of inflammatory response 1 P13725,P40189 158 2.08e-04 46 3 2 0.667 0.043 GO:0002526 BP 1 acute inflammatory response 1 P13725,P40189 158 3.92e-04 63 3 2 0.667 0.032 GO:0046425 BP 1 regulation of JAK-STAT cascade 1 P13725,P40189 158 3.92e-04 63 3 2 0.667 0.032 GO:1904892 BP 1 regulation of STAT cascade 1 P13725,P40189 158 4.05e-04 64 3 2 0.667 0.031 GO:0050731 BP 1 positive regulation of peptidyl-tyrosine phosphorylation 1 P13725,P40189 158 6.50e-04 81 3 2 0.667 0.025 GO:0007259 BP 1 JAK-STAT cascade 1 P13725,P40189 158 6.50e-04 81 3 2 0.667 0.025 GO:0097696 BP 1 STAT cascade 1 P13725,P40189 158 9.33e-04 97 3 2 0.667 0.021 GO:0050730 BP 1 regulation of peptidyl-tyrosine phosphorylation 1 P13725,P40189 158 1.05e-03 103 3 2 0.667 0.019 GO:0005126 MF 1 cytokine receptor binding 1 P13725,P40189 158 1.09e-03 105 3 2 0.667 0.019 GO:0032103 BP 1 positive regulation of response to external stimulus 1 P13725,P40189 158 1.16e-03 1 3 1 0.333 1.000 GO:0004915 MF 1 interleukin-6 receptor activity 1 P40189 158 1.16e-03 1 3 1 0.333 1.000 GO:0005147 MF 1 oncostatin-M receptor binding 1 P13725 158 1.16e-03 1 3 1 0.333 1.000 GO:0070106 BP 1 interleukin-27-mediated signaling pathway 1 P40189 158 1.16e-03 1 3 1 0.333 1.000 GO:0070110 CC 1 ciliary neurotrophic factor receptor complex 1 P40189 158 1.16e-03 1 3 1 0.333 1.000 GO:0045509 MF 1 interleukin-27 receptor activity 1 P40189 158 1.16e-03 1 3 1 0.333 1.000 GO:0019981 MF 1 interleukin-6 binding 1 P40189 158 1.43e-03 120 3 2 0.667 0.017 GO:0050727 BP 1 regulation of inflammatory response 1 P13725,P40189 158 1.97e-03 141 3 2 0.667 0.014 GO:0018108 BP 1 peptidyl-tyrosine phosphorylation 1 P13725,P40189 158 2.03e-03 143 3 2 0.667 0.014 GO:0018212 BP 1 peptidyl-tyrosine modification 1 P13725,P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0005127 MF 1 ciliary neurotrophic factor receptor binding 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0004897 MF 1 ciliary neurotrophic factor receptor activity 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0005900 CC 1 oncostatin-M receptor complex 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0048861 BP 1 leukemia inhibitory factor signaling pathway 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0070120 BP 1 ciliary neurotrophic factor-mediated signaling pathway 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0004923 MF 1 leukemia inhibitory factor receptor activity 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0030368 MF 1 interleukin-17 receptor activity 1 P40189 158 2.32e-03 2 3 1 0.333 0.500 GO:0005896 CC 1 interleukin-6 receptor complex 1 P40189 158 3.49e-03 3 3 1 0.333 0.333 GO:0004924 MF 1 oncostatin-M receptor activity 1 P40189 158 3.49e-03 3 3 1 0.333 0.333 GO:0042511 BP 1 positive regulation of tyrosine phosphorylation of Stat1 protein 1 P40189 158 4.97e-03 224 3 2 0.667 0.009 GO:0006954 BP 1 inflammatory response 1 P13725,P40189 158 5.05e-03 8 3 1 0.333 0.125 REAC:112411 rea 1 MAPK1 (ERK2) activation 1 P40189 158 5.68e-03 9 3 1 0.333 0.111 REAC:110056 rea 1 MAPK3 (ERK1) activation 1 P40189 158 5.68e-03 9 3 1 0.333 0.111 REAC:1059683 rea 1 Interleukin-6 signaling 1 P40189 158 5.81e-03 5 3 1 0.333 0.200 GO:0005138 MF 1 interleukin-6 receptor binding 1 P40189 158 6.08e-03 248 3 2 0.667 0.008 GO:0031349 BP 1 positive regulation of defense response 1 P13725,P40189 158 6.97e-03 6 3 1 0.333 0.167 GO:0042510 BP 1 regulation of tyrosine phosphorylation of Stat1 protein 1 P40189 158 6.97e-03 6 3 1 0.333 0.167 GO:0070102 BP 1 interleukin-6-mediated signaling pathway 1 P40189 158 6.97e-03 6 3 1 0.333 0.167 GO:0042508 BP 1 tyrosine phosphorylation of Stat1 protein 1 P40189 158 6.99e-03 287 3 2 0.667 0.007 REAC:449147 rea 1 Signaling by Interleukins 1 P13725,P40189 158 7.37e-03 273 3 2 0.667 0.007 GO:0019221 BP 1 cytokine-mediated signaling pathway 1 P13725,P40189 158 9.29e-03 8 3 1 0.333 0.125 GO:0010613 BP 1 positive regulation of cardiac muscle hypertrophy 1 P40189 158 9.29e-03 8 3 1 0.333 0.125 GO:0014742 BP 1 positive regulation of muscle hypertrophy 1 P40189 158 1.09e-02 333 3 2 0.667 0.006 GO:0008284 BP 1 positive regulation of cell proliferation 1 P13725,P40189 158 1.13e-02 18 3 1 0.333 0.056 REAC:112409 rea 1 RAF-independent MAPK1/3 activation 1 P40189 158 1.13e-02 18 3 1 0.333 0.056 REAC:3295583 rea 1 TRP channels 1 Q9HCF6 158 1.15e-02 341 3 2 0.667 0.006 GO:0071345 BP 1 cellular response to cytokine stimulus 1 P13725,P40189 158 1.19e-02 347 3 2 0.667 0.006 GO:0032101 BP 1 regulation of response to external stimulus 1 P13725,P40189 158 1.44e-02 383 3 2 0.667 0.005 GO:0031347 BP 1 regulation of defense response 1 P13725,P40189 158 1.51e-02 392 3 2 0.667 0.005 GO:0034097 BP 1 response to cytokine 1 P13725,P40189 158 1.63e-02 14 3 1 0.333 0.071 GO:0010611 BP 1 regulation of cardiac muscle hypertrophy 1 P40189 158 1.63e-02 14 3 1 0.333 0.071 GO:0014743 BP 1 regulation of muscle hypertrophy 1 P40189 158 1.63e-02 14 3 1 0.333 0.071 GO:0071354 BP 1 cellular response to interleukin-6 1 P40189 158 1.63e-02 14 3 1 0.333 0.071 GO:0010575 BP 1 positive regulation of vascular endothelial growth factor production 1 P40189 158 1.66e-02 446 3 2 0.667 0.004 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 P13725,P40189 158 1.74e-02 15 3 1 0.333 0.067 GO:0070741 BP 1 response to interleukin-6 1 P40189 158 1.74e-02 15 3 1 0.333 0.067 GO:0010574 BP 1 regulation of vascular endothelial growth factor production 1 P40189 158 1.86e-02 16 3 1 0.333 0.062 GO:0010573 BP 1 vascular endothelial growth factor production 1 P40189 158 2.04e-02 188 3 2 0.667 0.011 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 P13725,P40189 158 2.06e-02 459 3 2 0.667 0.004 GO:0001934 BP 1 positive regulation of protein phosphorylation 1 P13725,P40189 158 2.20e-02 19 3 1 0.333 0.053 GO:0046888 BP 1 negative regulation of hormone secretion 1 P13725 158 2.28e-02 483 3 2 0.667 0.004 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 P13725,P40189 158 2.29e-02 484 3 2 0.667 0.004 GO:0042327 BP 1 positive regulation of phosphorylation 1 P13725,P40189 158 2.44e-02 21 3 1 0.333 0.048 GO:0003300 BP 1 cardiac muscle hypertrophy 1 P40189 158 2.44e-02 21 3 1 0.333 0.048 GO:0014897 BP 1 striated muscle hypertrophy 1 P40189 158 2.50e-02 2 3 1 0.333 0.500 CORUM:5582 cor 1 LIFR-LIF-gp130 complex 1 P40189 158 2.50e-02 2 3 1 0.333 0.500 CORUM:3229 cor 1 Heterodimer complex (CDK9, IL6ST) 1 P40189 158 2.50e-02 2 3 1 0.333 0.500 CORUM:5579 cor 1 CNTF-CNTFR-gp130-LIFR complex 1 P40189 158 2.55e-02 22 3 1 0.333 0.045 GO:0014896 BP 1 muscle hypertrophy 1 P40189 158 2.55e-02 22 3 1 0.333 0.045 GO:0043502 BP 1 regulation of muscle adaptation 1 P40189 158 2.55e-02 22 3 1 0.333 0.045 GO:0045669 BP 1 positive regulation of osteoblast differentiation 1 P40189 158 2.67e-02 23 3 1 0.333 0.043 GO:0004896 MF 1 cytokine receptor activity 1 P40189 158 2.73e-02 529 3 2 0.667 0.004 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 P13725,P40189 158 2.73e-02 529 3 2 0.667 0.004 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 P13725,P40189 158 3.25e-02 28 3 1 0.333 0.036 GO:0043500 BP 1 muscle adaptation 1 P40189 158 3.25e-02 28 3 1 0.333 0.036 GO:0002821 BP 1 positive regulation of adaptive immune response 1 P40189 158 3.75e-02 3 3 1 0.333 0.333 CORUM:1519 cor 1 IL6ST-PRKCD-STAT3 complex 1 P40189 158 3.82e-02 33 3 1 0.333 0.030 GO:0042102 BP 1 positive regulation of T cell proliferation 1 P40189 158 3.82e-02 33 3 1 0.333 0.030 GO:0045778 BP 1 positive regulation of ossification 1 P40189 158 4.09e-02 650 3 2 0.667 0.003 GO:0031401 BP 1 positive regulation of protein modification process 1 P13725,P40189 158 4.29e-02 666 3 2 0.667 0.003 GO:0006952 BP 1 defense response 1 P13725,P40189 158 4.37e-02 672 3 2 0.667 0.003 GO:0042127 BP 1 regulation of cell proliferation 1 P13725,P40189 158 4.73e-02 700 3 2 0.667 0.003 GO:0001932 BP 1 regulation of protein phosphorylation 1 P13725,P40189 158 4.76e-02 82 3 2 0.667 0.024 KEGG:04630 keg 1 Jak-STAT signaling pathway 1 P13725,P40189 158 4.98e-02 43 3 1 0.333 0.023 GO:0008083 MF 1 growth factor activity 1 P13725 158 5.00e-02 295 3 2 0.667 0.007 TF:M04211_1 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 1 1 P13725,P40189 158 5.00e-02 4 3 1 0.333 0.250 CORUM:5564 cor 1 LMO4-gp130 complex 1 P40189 158 5.00e-02 295 3 2 0.667 0.007 TF:M04504_0 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 0 1 P13725,P40189 158 5.00e-02 720 3 2 0.667 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 P13725,P40189 158 5.00e-02 80 3 1 0.333 0.013 REAC:2672351 rea 1 Stimuli-sensing channels 1 Q9HCF6 158 5.00e-02 84 3 2 0.667 0.024 KEGG:04060 keg 1 Cytokine-cytokine receptor interaction 1 P13725,P40189 158 5.00e-02 295 3 2 0.667 0.007 TF:M04211_0 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 0 1 P13725,P40189 158 5.00e-02 295 3 2 0.667 0.007 TF:M04504_1 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 1 1 P13725,P40189 159 4.47e-03 4 3 1 0.333 0.250 REAC:166187 rea 1 Mitochondrial Uncoupling Proteins 1 P55851 159 4.47e-03 4 3 1 0.333 0.250 REAC:167826 rea 1 The fatty acid cycling model 1 P55851 159 4.47e-03 4 3 1 0.333 0.250 REAC:167827 rea 1 The proton buffering model 1 P55851 159 9.77e-03 12 3 1 0.333 0.083 KEGG:00360 keg 1 Phenylalanine metabolism 1 P30838 159 1.46e-02 18 3 1 0.333 0.056 KEGG:00340 keg 1 Histidine metabolism 1 P30838 159 2.11e-02 26 3 1 0.333 0.038 KEGG:00410 keg 1 beta-Alanine metabolism 1 P30838 159 2.27e-02 28 3 1 0.333 0.036 KEGG:00350 keg 1 Tyrosine metabolism 1 P30838 159 3.33e-02 194 3 2 0.667 0.010 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 P30838,P55851 159 4.20e-02 52 3 1 0.333 0.019 KEGG:00982 keg 1 Drug metabolism - cytochrome P450 1 P30838 159 4.44e-02 55 3 1 0.333 0.018 KEGG:00980 keg 1 Metabolism of xenobiotics by cytochrome P450 1 P30838 159 4.49e-02 376 3 2 0.667 0.005 MI:hsa-miR-92a-1* mi 1 MI:hsa-miR-92a-1* 1 P30838,P55851 159 4.57e-02 4 3 1 0.333 0.250 TF:M05855_0 tf 1 Factor: ZNF312; motif: GAAGGGAAATGNAAC; match class: 0 1 Q14330 159 4.68e-02 58 3 1 0.333 0.017 KEGG:05204 keg 1 Chemical carcinogenesis 1 P30838 159 4.98e-02 396 3 2 0.667 0.005 MI:hsa-miR-877 mi 1 MI:hsa-miR-877 1 P30838,P55851 159 5.00e-02 397 3 2 0.667 0.005 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 Q14330,P55851 159 5.00e-02 1 3 1 0.333 1.000 GO:0018479 MF 1 benzaldehyde dehydrogenase (NAD+) activity 1 P30838 159 5.00e-02 45 3 1 0.333 0.022 REAC:211945 rea 1 Phase 1 - Functionalization of compounds 1 P30838 159 5.00e-02 1287 3 3 1.000 0.002 TF:M02016_1 tf 1 Factor: HNF-4alpha; motif: GNNCAAAGKYCANNN; match class: 1 1 P30838,Q14330,P55851 159 5.00e-02 1 3 1 0.333 1.000 OMIM:607447 omi 1 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 4; BMIQ4;;OBESITY, SUSCEPTIBILITY TO 1 P55851 159 5.00e-02 62 3 1 0.333 0.016 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P30838 160 3.78e-03 117 5 2 0.400 0.017 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 Q8TDN4,Q9BTV7 160 1.21e-02 5 5 1 0.200 0.200 TF:M05900_0 tf 1 Factor: znf439; motif: KGGGCCAAGCGA; match class: 0 1 Q86YS7 160 1.55e-02 205 5 2 0.400 0.010 TF:M07376_1 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 1 1 Q86YS7,O43427 160 1.56e-02 206 5 2 0.400 0.010 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 Q8TDN4,O43427 160 1.96e-02 4029 5 5 1.000 0.001 TF:M01199_1 tf 1 Factor: RNF96; motif: BCCCGCRGCC; match class: 1 1 Q86YS7,Q8TDN4,Q9BTV7,O43427,Q12767 160 3.40e-02 14 5 1 0.200 0.071 TF:M02094_1 tf 1 Factor: ERR3; motif: NNTCAAGGTCACN; match class: 1 1 Q9BTV7 160 3.40e-02 14 5 1 0.200 0.071 TF:M06378_0 tf 1 Factor: ZNF562; motif: NKGGTCATAAGC; match class: 0 1 O43427 160 3.64e-02 15 5 1 0.200 0.067 TF:M07398_1 tf 1 Factor: Brn-3b; motif: RCTCATTAAN; match class: 1 1 Q86YS7 160 3.64e-02 15 5 1 0.200 0.067 TF:M04243_0 tf 1 Factor: FOXG1; motif: RCGGACACAATR; match class: 0 1 Q8TDN4 160 3.75e-02 3 5 1 0.200 0.333 GO:0038028 BP 1 insulin receptor signaling pathway via phosphatidylinositol 3-kinase 1 Q86YS7 160 4.12e-02 17 5 1 0.200 0.059 TF:M05887_0 tf 1 Factor: ZNF837; motif: KGGGWAGGCCGC; match class: 0 1 Q86YS7 160 4.36e-02 18 5 1 0.200 0.056 TF:M05948_0 tf 1 Factor: ZNF582; motif: NTGGAAGAACGC; match class: 0 1 O43427 160 4.78e-02 2641 5 4 0.800 0.002 TF:M00947_0 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 0 1 Q86YS7,Q8TDN4,Q9BTV7,Q12767 160 4.85e-02 20 5 1 0.200 0.050 TF:M06113_0 tf 1 Factor: ZNF325; motif: NCCGGCTCCTGA; match class: 0 1 O43427 160 5.00e-02 2673 5 4 0.800 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 Q86YS7,Q8TDN4,Q9BTV7,O43427 160 5.00e-02 535 5 3 0.600 0.006 MI:hsa-miR-181a mi 1 MI:hsa-miR-181a 1 Q86YS7,O43427,Q12767 160 5.00e-02 4 5 1 0.200 0.250 GO:0031340 BP 1 positive regulation of vesicle fusion 1 Q86YS7 160 5.00e-02 444 5 2 0.400 0.005 REAC:109582 rea 1 Hemostasis 1 Q8TDN4,Q9BTV7 160 5.00e-02 2673 5 4 0.800 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 Q86YS7,Q8TDN4,Q9BTV7,O43427 161 3.58e-03 1 3 1 0.333 1.000 GO:0090222 BP 1 centrosome-templated microtubule nucleation 1 Q8N4C6 161 4.10e-03 477 3 2 0.667 0.004 TF:M05304_0 tf 1 Factor: Zbtb5; motif: AGGRAGCTTC; match class: 0 1 Q8N4C6,Q9GZS3 161 5.07e-03 2188 3 3 1.000 0.001 TF:M00622_0 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 0 1 Q8N4C6,A5PLN9,Q9GZS3 161 7.15e-03 2 3 1 0.333 0.500 GO:2001160 BP 1 regulation of histone H3-K79 methylation 1 Q9GZS3 161 7.15e-03 2 3 1 0.333 0.500 GO:2001162 BP 1 positive regulation of histone H3-K79 methylation 1 Q9GZS3 161 7.16e-03 1 3 1 0.333 1.000 OMIM:614851 omi 1 SECKEL SYNDROME 7; SCKL7 1 Q8N4C6 161 7.52e-03 32 3 1 0.333 0.031 TF:M06613_0 tf 1 Factor: ZNF514; motif: NGTTGATTMAGM; match class: 0 1 A5PLN9 161 9.83e-03 2727 3 3 1.000 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 Q8N4C6,A5PLN9,Q9GZS3 161 1.07e-02 3 3 1 0.333 0.333 GO:0034729 BP 1 histone H3-K79 methylation 1 Q9GZS3 161 1.07e-02 3 3 1 0.333 0.333 GO:0055087 CC 1 Ski complex 1 Q9GZS3 161 1.30e-02 859 3 2 0.667 0.002 TF:M07307_0 tf 1 Factor: Sox18; motif: ACAAWGBSNNN; match class: 0 1 Q8N4C6,A5PLN9 161 1.36e-02 878 3 2 0.667 0.002 TF:M04235_1 tf 1 Factor: FOXC2; motif: NGTMAATATTKACN; match class: 1 1 Q8N4C6,A5PLN9 161 1.40e-02 890 3 2 0.667 0.002 TF:M02909_1 tf 1 Factor: SOX4; motif: NNNNNAATTGTTNNNNN; match class: 1 1 A5PLN9,Q9GZS3 161 1.41e-02 16 3 1 0.333 0.062 REAC:429958 rea 1 mRNA decay by 3' to 5' exoribonuclease 1 Q9GZS3 161 1.43e-02 4 3 1 0.333 0.250 GO:0036449 CC 1 microtubule minus-end 1 Q8N4C6 161 1.46e-02 3109 3 3 1.000 0.001 TF:M00809_1 tf 1 Factor: FOX; motif: KWTTGTTTRTTTW; match class: 1 1 Q8N4C6,A5PLN9,Q9GZS3 161 1.50e-02 64 3 1 0.333 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 A5PLN9 161 1.59e-02 68 3 1 0.333 0.015 TF:M06425_0 tf 1 Factor: ZNF227; motif: NSAAGGGTGARA; match class: 0 1 Q9GZS3 161 1.90e-02 81 3 1 0.333 0.012 TF:M06313_0 tf 1 Factor: ZNF678; motif: KGTTAAAAGAGA; match class: 0 1 Q8N4C6 161 2.04e-02 87 3 1 0.333 0.011 TF:M06727_1 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 1 1 A5PLN9 161 2.06e-02 88 3 1 0.333 0.011 TF:M04120_0 tf 1 Factor: TBR1; motif: AAGGTGTGAAA; match class: 0 1 A5PLN9 161 2.14e-02 6 3 1 0.333 0.167 GO:0034454 BP 1 microtubule anchoring at centrosome 1 Q8N4C6 161 2.14e-02 6 3 1 0.333 0.167 GO:0016593 CC 1 Cdc73/Paf1 complex 1 Q9GZS3 161 2.22e-02 95 3 1 0.333 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 A5PLN9 161 2.22e-02 95 3 1 0.333 0.011 TF:M06111_0 tf 1 Factor: ZNF254; motif: NGKTGCGGACGM; match class: 0 1 Q8N4C6 161 2.49e-02 1197 3 2 0.667 0.002 TF:M07319_1 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 1 1 Q8N4C6,Q9GZS3 161 2.50e-02 7 3 1 0.333 0.143 GO:0097539 CC 1 ciliary transition fiber 1 Q8N4C6 161 2.50e-02 7 3 1 0.333 0.143 GO:0080182 BP 1 histone H3-K4 trimethylation 1 Q9GZS3 161 2.50e-02 3 3 1 0.333 0.333 HP:0004626 hp 1 Lumbar scoliosis 1 Q8N4C6 161 2.66e-02 114 3 1 0.333 0.009 TF:M06155_0 tf 1 Factor: ZNF135; motif: NGTKGTGWAATC; match class: 0 1 A5PLN9 161 2.73e-02 3835 3 3 1.000 0.001 TF:M02909_0 tf 1 Factor: SOX4; motif: NNNNNAATTGTTNNNNN; match class: 0 1 Q8N4C6,A5PLN9,Q9GZS3 161 2.81e-02 1276 3 2 0.667 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 A5PLN9,Q9GZS3 161 2.86e-02 8 3 1 0.333 0.125 GO:0072393 BP 1 microtubule anchoring at microtubule organizing center 1 Q8N4C6 161 2.86e-02 8 3 1 0.333 0.125 GO:0097431 CC 1 mitotic spindle pole 1 Q8N4C6 161 2.90e-02 3909 3 3 1.000 0.001 TF:M03830_1 tf 1 Factor: MafB; motif: CRCTGACNANN; match class: 1 1 Q8N4C6,A5PLN9,Q9GZS3 161 2.93e-02 1303 3 2 0.667 0.002 TF:M04235_0 tf 1 Factor: FOXC2; motif: NGTMAATATTKACN; match class: 0 1 Q8N4C6,A5PLN9 161 3.00e-02 3 3 1 0.333 0.333 CORUM:1168 cor 1 SKI complex 1 Q9GZS3 161 3.03e-02 130 3 1 0.333 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 Q9GZS3 161 3.10e-02 3999 3 3 1.000 0.001 TF:M07255_1 tf 1 Factor: Foxm1; motif: NTGTTTRT; match class: 1 1 Q8N4C6,A5PLN9,Q9GZS3 161 3.25e-02 4064 3 3 1.000 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 Q8N4C6,A5PLN9,Q9GZS3 161 3.33e-02 143 3 1 0.333 0.007 TF:M06082_0 tf 1 Factor: ZNF716; motif: NCAGGCAGCGGA; match class: 0 1 Q8N4C6 161 3.57e-02 10 3 1 0.333 0.100 GO:0051642 BP 1 centrosome localization 1 Q8N4C6 161 3.68e-02 4233 3 3 1.000 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 Q8N4C6,A5PLN9,Q9GZS3 161 3.95e-02 170 3 1 0.333 0.006 TF:M06871_0 tf 1 Factor: ZNF224; motif: NAATGCYAATCY; match class: 0 1 A5PLN9 161 4.09e-02 176 3 1 0.333 0.006 TF:M03538_1 tf 1 Factor: AP-1; motif: TGACTCAN; match class: 1 1 Q8N4C6 161 4.09e-02 176 3 1 0.333 0.006 TF:M03869_1 tf 1 Factor: Fra-1; motif: TGACTCAN; match class: 1 1 Q8N4C6 161 4.09e-02 176 3 1 0.333 0.006 TF:M03552_1 tf 1 Factor: JunD; motif: TGACTCAN; match class: 1 1 Q8N4C6 161 4.09e-02 4387 3 3 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 Q8N4C6,A5PLN9,Q9GZS3 161 4.17e-02 5 3 1 0.333 0.200 HP:0011787 hp 1 Central hypothyroidism 1 Q8N4C6 161 4.35e-02 1601 3 2 0.667 0.001 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 Q8N4C6,A5PLN9 161 4.41e-02 1614 3 2 0.667 0.001 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 Q8N4C6,Q9GZS3 161 4.44e-02 191 3 1 0.333 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 A5PLN9 161 4.46e-02 192 3 1 0.333 0.005 TF:M01119_0 tf 1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 0 1 Q8N4C6 161 4.50e-02 194 3 1 0.333 0.005 TF:M06860_0 tf 1 Factor: ZNF549; motif: NCTTTTWTGGGA; match class: 0 1 A5PLN9 161 4.64e-02 13 3 1 0.333 0.077 GO:0032968 BP 1 positive regulation of transcription elongation from RNA polymerase II promoter 1 Q9GZS3 161 4.64e-02 13 3 1 0.333 0.077 GO:0051571 BP 1 positive regulation of histone H3-K4 methylation 1 Q9GZS3 161 4.72e-02 4602 3 3 1.000 0.001 TF:M00623_0 tf 1 Factor: Crx; motif: YNNNTAATCYSMN; match class: 0 1 Q8N4C6,A5PLN9,Q9GZS3 161 4.74e-02 54 3 1 0.333 0.019 REAC:429914 rea 1 Deadenylation-dependent mRNA decay 1 Q9GZS3 161 4.91e-02 212 3 1 0.333 0.005 TF:M05770_0 tf 1 Factor: ZNFpT1; motif: GTWTTTTCGA; match class: 0 1 Q9GZS3 161 5.00e-02 7 3 1 0.333 0.143 OMIM:210600 omi 1 Seckel Syndrome 1 Q8N4C6 161 5.00e-02 71 3 1 0.333 0.014 KEGG:03018 keg 1 RNA degradation 1 Q9GZS3 161 5.00e-02 5 3 1 0.333 0.200 CORUM:1167 cor 1 Paf complex 1 Q9GZS3 161 5.00e-02 57 3 1 0.333 0.018 REAC:112382 rea 1 Formation of RNA Pol II elongation complex 1 Q9GZS3 161 5.00e-02 314 3 2 0.667 0.006 MI:hsa-miR-425* mi 1 MI:hsa-miR-425* 1 Q8N4C6,Q9GZS3 161 5.00e-02 14 3 1 0.333 0.071 GO:0000242 CC 1 pericentriolar material 1 Q8N4C6 161 5.00e-02 6 3 1 0.333 0.167 HP:0003067 hp 1 Madelung deformity 1 Q8N4C6 161 5.00e-02 14 3 1 0.333 0.071 GO:0034453 BP 1 microtubule anchoring 1 Q8N4C6 161 5.00e-02 57 3 1 0.333 0.018 REAC:75955 rea 1 RNA Polymerase II Transcription Elongation 1 Q9GZS3 162 2.04e-03 13 2 1 0.500 0.077 TF:M05647_0 tf 1 Factor: HKR1; motif: KGGTGAAAAAGC; match class: 0 1 O60678 162 3.92e-03 25 2 1 0.500 0.040 TF:M05915_0 tf 1 Factor: ZBTB20; motif: NGGTWAAGCSGG; match class: 0 1 O60678 162 8.69e-03 1187 2 2 1.000 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 Q9BRP1,O60678 162 1.05e-02 67 2 1 0.500 0.015 TF:M07372_1 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 1 1 O60678 162 1.43e-02 1524 2 2 1.000 0.001 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q9BRP1,O60678 162 1.45e-02 1531 2 2 1.000 0.001 TF:M00806_1 tf 1 Factor: NF-1; motif: NTGGNNNNNNGCCAANN; match class: 1 1 Q9BRP1,O60678 162 1.67e-02 107 2 1 0.500 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 O60678 162 2.11e-02 1849 2 2 1.000 0.001 TF:M00193_1 tf 1 Factor: NF-1; motif: NNTTGGCNNNNNNCCNNN; match class: 1 1 Q9BRP1,O60678 162 2.16e-02 138 2 1 0.500 0.007 TF:M05994_0 tf 1 Factor: ZNF230; motif: NSNTAAAAACRA; match class: 0 1 Q9BRP1 162 2.28e-02 146 2 1 0.500 0.007 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 O60678 162 2.45e-02 1994 2 2 1.000 0.001 TF:M00980_1 tf 1 Factor: TBP; motif: TTTATAN; match class: 1 1 Q9BRP1,O60678 162 2.59e-02 2050 2 2 1.000 0.001 TF:M00216_1 tf 1 Factor: TATA; motif: NCTATAAAAR; match class: 1 1 Q9BRP1,O60678 162 2.61e-02 2057 2 2 1.000 0.001 TF:M00482_0 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 0 1 Q9BRP1,O60678 162 2.64e-02 2070 2 2 1.000 0.001 TF:M05961_0 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 0 1 Q9BRP1,O60678 162 2.95e-02 2188 2 2 1.000 0.001 TF:M00622_0 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 0 1 Q9BRP1,O60678 162 2.98e-02 191 2 1 0.500 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 O60678 162 3.12e-02 200 2 1 0.500 0.005 TF:M07403_0 tf 1 Factor: FOXP2; motif: NWGTAAACARN; match class: 0 1 Q9BRP1 162 3.18e-02 7 2 1 0.500 0.143 GO:0035242 MF 1 protein-arginine omega-N asymmetric methyltransferase activity 1 O60678 162 3.35e-02 2331 2 2 1.000 0.001 TF:M01223_0 tf 1 Factor: P50:P50; motif: NRGGGAMTNCCCN; match class: 0 1 Q9BRP1,O60678 162 3.55e-02 228 2 1 0.500 0.004 TF:M06293_0 tf 1 Factor: ZNF742; motif: NGGGACGAGGSC; match class: 0 1 O60678 162 3.63e-02 233 2 1 0.500 0.004 TF:M05312_0 tf 1 Factor: FKLF; motif: AGGGCGGGTG; match class: 0 1 Q9BRP1 162 3.63e-02 233 2 1 0.500 0.004 TF:M05360_0 tf 1 Factor: TIEG-1; motif: WGGGCGGGTG; match class: 0 1 Q9BRP1 162 3.63e-02 233 2 1 0.500 0.004 TF:M05552_0 tf 1 Factor: SP5; motif: NGGGCGGGTS; match class: 0 1 Q9BRP1 162 3.63e-02 233 2 1 0.500 0.004 TF:M05553_0 tf 1 Factor: SP8; motif: WGGGCGGGTS; match class: 0 1 Q9BRP1 162 3.63e-02 233 2 1 0.500 0.004 TF:M05493_0 tf 1 Factor: SP9; motif: NGGGCGGGTS; match class: 0 1 Q9BRP1 162 3.64e-02 8 2 1 0.500 0.125 GO:0008469 MF 1 histone-arginine N-methyltransferase activity 1 O60678 162 3.64e-02 2428 2 2 1.000 0.001 TF:M02093_0 tf 1 Factor: ERR1; motif: CAAGGTCAMNN; match class: 0 1 Q9BRP1,O60678 162 4.31e-02 277 2 1 0.500 0.004 TF:M05916_0 tf 1 Factor: ZNF407; motif: NGGTGAAARARC; match class: 0 1 O60678 162 4.74e-02 305 2 1 0.500 0.003 TF:M00930_1 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 1 1 Q9BRP1 162 4.88e-02 2813 2 2 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 Q9BRP1,O60678 162 5.00e-02 11 2 1 0.500 0.091 GO:0016274 MF 1 protein-arginine N-methyltransferase activity 1 O60678 162 5.00e-02 11 2 1 0.500 0.091 GO:0016273 MF 1 arginine N-methyltransferase activity 1 O60678 163 4.18e-03 1 6 1 0.167 1.000 GO:0006235 BP 1 dTTP biosynthetic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0006227 BP 1 dUDP biosynthetic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0009196 BP 1 pyrimidine deoxyribonucleoside diphosphate metabolic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0046075 BP 1 dTTP metabolic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0009041 MF 1 uridylate kinase activity 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0046072 BP 1 dTDP metabolic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0006233 BP 1 dTDP biosynthetic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0009139 BP 1 pyrimidine nucleoside diphosphate biosynthetic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0046077 BP 1 dUDP metabolic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0004798 MF 1 thymidylate kinase activity 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0009197 BP 1 pyrimidine deoxyribonucleoside diphosphate biosynthetic process 1 P23919 163 4.18e-03 1 6 1 0.167 1.000 GO:0009212 BP 1 pyrimidine deoxyribonucleoside triphosphate biosynthetic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0009202 BP 1 deoxyribonucleoside triphosphate biosynthetic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0009189 BP 1 deoxyribonucleoside diphosphate biosynthetic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0009133 BP 1 nucleoside diphosphate biosynthetic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0042583 CC 1 chromaffin granule 1 P30626 163 8.35e-03 2 6 1 0.167 0.500 GO:0009148 BP 1 pyrimidine nucleoside triphosphate biosynthetic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0009138 BP 1 pyrimidine nucleoside diphosphate metabolic process 1 P23919 163 8.35e-03 2 6 1 0.167 0.500 GO:0042584 CC 1 chromaffin granule membrane 1 P30626 163 8.35e-03 2 6 1 0.167 0.500 GO:0009211 BP 1 pyrimidine deoxyribonucleoside triphosphate metabolic process 1 P23919 163 1.25e-02 3 6 1 0.167 0.333 GO:0009221 BP 1 pyrimidine deoxyribonucleotide biosynthetic process 1 P23919 163 1.25e-02 3 6 1 0.167 0.333 GO:0004719 MF 1 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 1 P22061 163 1.25e-02 3 6 1 0.167 0.333 GO:0010459 BP 1 negative regulation of heart rate 1 P30626 163 1.50e-02 252 6 2 0.333 0.008 MI:hsa-miR-130b* mi 1 MI:hsa-miR-130b* 1 P22061,A8MPS7 163 1.67e-02 4 6 1 0.167 0.250 GO:1901077 BP 1 regulation of relaxation of muscle 1 P30626 163 1.67e-02 4 6 1 0.167 0.250 GO:1901844 BP 1 regulation of cell communication by electrical coupling involved in cardiac conduction 1 P30626 163 1.67e-02 4 6 1 0.167 0.250 GO:0097577 BP 1 sequestering of iron ion 1 P30626 163 1.67e-02 4 6 1 0.167 0.250 GO:0047105 MF 1 4-trimethylammoniobutyraldehyde dehydrogenase activity 1 Q8IZ83 163 1.67e-02 4 6 1 0.167 0.250 GO:0019145 MF 1 aminobutyraldehyde dehydrogenase activity 1 Q8IZ83 163 1.67e-02 4 6 1 0.167 0.250 GO:0009265 BP 1 2'-deoxyribonucleotide biosynthetic process 1 P23919 163 1.67e-02 4 6 1 0.167 0.250 GO:0009186 BP 1 deoxyribonucleoside diphosphate metabolic process 1 P23919 163 1.67e-02 4 6 1 0.167 0.250 GO:0006880 BP 1 intracellular sequestering of iron ion 1 P30626 163 1.67e-02 4 6 1 0.167 0.250 GO:0046385 BP 1 deoxyribose phosphate biosynthetic process 1 P23919 163 1.67e-02 4 6 1 0.167 0.250 GO:1901841 BP 1 regulation of high voltage-gated calcium channel activity 1 P30626 163 1.67e-02 4 6 1 0.167 0.250 GO:0009147 BP 1 pyrimidine nucleoside triphosphate metabolic process 1 P23919 163 2.09e-02 5 6 1 0.167 0.200 GO:0050145 MF 1 nucleoside phosphate kinase activity 1 P23919 163 2.25e-02 311 6 2 0.333 0.006 MI:hsa-miR-431* mi 1 MI:hsa-miR-431* 1 A8MPS7,P23919 163 2.50e-02 1 6 1 0.167 1.000 CORUM:5372 cor 1 SRI homodimer complex 1 P30626 163 2.50e-02 6 6 1 0.167 0.167 GO:0010340 MF 1 carboxyl-O-methyltransferase activity 1 P22061 163 2.50e-02 6 6 1 0.167 0.167 GO:0051998 MF 1 protein carboxyl O-methyltransferase activity 1 P22061 163 2.50e-02 6 6 1 0.167 0.167 GO:0030091 BP 1 protein repair 1 P22061 163 2.80e-02 348 6 2 0.333 0.006 MI:hsa-miR-937 mi 1 MI:hsa-miR-937 1 P22061,P23919 163 2.91e-02 355 6 2 0.333 0.006 MI:hsa-miR-99a* mi 1 MI:hsa-miR-99a* 1 P22061,A8MPS7 163 2.92e-02 7 6 1 0.167 0.143 GO:0009263 BP 1 deoxyribonucleotide biosynthetic process 1 P23919 163 2.92e-02 7 6 1 0.167 0.143 GO:0010649 BP 1 regulation of cell communication by electrical coupling 1 P30626 163 2.92e-02 7 6 1 0.167 0.143 GO:0009200 BP 1 deoxyribonucleoside triphosphate metabolic process 1 P23919 163 2.92e-02 7 6 1 0.167 0.143 GO:0045822 BP 1 negative regulation of heart contraction 1 P30626 163 3.32e-02 247 6 3 0.500 0.012 TF:M05755_0 tf 1 Factor: ZNF718; motif: GTTAAGGARA; match class: 0 1 P30626,O94889,P22061 163 3.34e-02 8 6 1 0.167 0.125 GO:0060315 BP 1 negative regulation of ryanodine-sensitive calcium-release channel activity 1 P30626 163 3.34e-02 8 6 1 0.167 0.125 GO:0006221 BP 1 pyrimidine nucleotide biosynthetic process 1 P23919 163 3.34e-02 8 6 1 0.167 0.125 GO:0051280 BP 1 negative regulation of release of sequestered calcium ion into cytosol 1 P30626 163 3.65e-02 400 6 2 0.333 0.005 MI:mmu-miR-805 mi 1 MI:mmu-miR-805 1 P22061,P23919 163 3.75e-02 9 6 1 0.167 0.111 GO:0010523 BP 1 negative regulation of calcium ion transport into cytosol 1 P30626 163 3.75e-02 9 6 1 0.167 0.111 GO:0051284 BP 1 positive regulation of sequestering of calcium ion 1 P30626 163 3.81e-02 409 6 2 0.333 0.005 MI:hsa-miR-641 mi 1 MI:hsa-miR-641 1 A8MPS7,P23919 163 4.12e-02 426 6 2 0.333 0.005 MI:hsa-miR-28-3p mi 1 MI:hsa-miR-28-3p 1 P22061,A8MPS7 163 4.21e-02 431 6 2 0.333 0.005 MI:hsa-miR-433 mi 1 MI:hsa-miR-433 1 P30626,P23919 163 4.27e-02 434 6 2 0.333 0.005 MI:hsa-miR-139-3p mi 1 MI:hsa-miR-139-3p 1 Q8IZ83,P23919 163 4.27e-02 434 6 2 0.333 0.005 MI:hsa-miR-298 mi 1 MI:hsa-miR-298 1 P22061,P23919 163 4.40e-02 441 6 2 0.333 0.005 MI:hsa-miR-623 mi 1 MI:hsa-miR-623 1 P22061,Q8IZ83 163 4.40e-02 441 6 2 0.333 0.005 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 P22061,A8MPS7 163 4.58e-02 11 6 1 0.167 0.091 GO:1903523 BP 1 negative regulation of blood circulation 1 P30626 163 4.58e-02 11 6 1 0.167 0.091 GO:0090281 BP 1 negative regulation of calcium ion import 1 P30626 163 4.58e-02 11 6 1 0.167 0.091 GO:0009219 BP 1 pyrimidine deoxyribonucleotide metabolic process 1 P23919 163 4.63e-02 453 6 2 0.333 0.004 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 Q8IZ83,P23919 163 4.67e-02 455 6 2 0.333 0.004 MI:hsa-miR-198 mi 1 MI:hsa-miR-198 1 A8MPS7,Q8IZ83 163 4.82e-02 463 6 2 0.333 0.004 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 P22061,A8MPS7 163 4.88e-02 466 6 2 0.333 0.004 MI:hsa-miR-627 mi 1 MI:hsa-miR-627 1 P22061,P23919 163 5.00e-02 12 6 1 0.167 0.083 GO:0090075 BP 1 relaxation of muscle 1 P30626 163 5.00e-02 12 6 1 0.167 0.083 GO:0050849 BP 1 negative regulation of calcium-mediated signaling 1 P30626 163 5.00e-02 472 6 2 0.333 0.004 MI:hsa-miR-574-3p mi 1 MI:hsa-miR-574-3p 1 Q8IZ83,P23919 163 5.00e-02 2 6 1 0.167 0.500 CORUM:5371 cor 1 Grancalcin-sorcin complex 1 P30626 163 5.00e-02 12 6 1 0.167 0.083 GO:1901385 BP 1 regulation of voltage-gated calcium channel activity 1 P30626 163 5.00e-02 5 6 1 0.167 0.200 REAC:5676934 rea 1 Protein repair 1 P22061 163 5.00e-02 3100 6 6 1.000 0.002 TF:M00377_1 tf 1 Factor: Pax-4; motif: NAAWAATTANS; match class: 1 1 P30626,O94889,P22061,A8MPS7,Q8IZ83,P23919 164 1.82e-10 61 7 5 0.714 0.082 GO:0005643 CC 1 nuclear pore 1 Q9UKX7,P46060,P49790,P49792,O14715 164 1.59e-08 33 7 4 0.571 0.121 REAC:165054 rea 1 Rev-mediated nuclear export of HIV RNA 1 Q9UKX7,P46060,P49790,P49792 164 2.04e-08 35 7 4 0.571 0.114 REAC:177243 rea 1 Interactions of Rev with host cellular proteins 1 Q9UKX7,P46060,P49790,P49792 164 5.27e-08 44 7 4 0.571 0.091 REAC:4615885 rea 1 SUMOylation of DNA replication proteins 1 Q9UKX7,P46060,P49790,P49792 164 2.06e-07 244 7 5 0.714 0.020 GO:0005635 CC 1 nuclear envelope 1 Q9UKX7,P46060,P49790,P49792,O14715 164 2.32e-07 17 7 3 0.429 0.176 GO:0008536 MF 1 Ran GTPase binding 1 Q9UKX7,P49792,O14715 164 9.52e-07 120 7 4 0.571 0.033 GO:0016925 BP 1 protein sumoylation 1 Q9UKX7,P46060,P49790,P49792 164 1.43e-06 99 7 4 0.571 0.040 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 Q9UKX7,P46060,P49790,P49792 164 1.53e-06 31 7 3 0.429 0.097 GO:0006409 BP 1 tRNA export from nucleus 1 Q9UKX7,P49790,P49792 164 1.53e-06 31 7 3 0.429 0.097 GO:0071431 BP 1 tRNA-containing ribonucleoprotein complex export from nucleus 1 Q9UKX7,P49790,P49792 164 1.82e-06 105 7 4 0.571 0.038 REAC:2990846 rea 1 SUMOylation 1 Q9UKX7,P46060,P49790,P49792 164 1.85e-06 33 7 3 0.429 0.091 GO:0051031 BP 1 tRNA transport 1 Q9UKX7,P49790,P49792 164 2.15e-06 147 7 4 0.571 0.027 GO:0031965 CC 1 nuclear membrane 1 Q9UKX7,P46060,P49790,P49792 164 2.53e-06 153 7 4 0.571 0.026 GO:0051168 BP 1 nuclear export 1 Q9UKX7,P46060,P49790,P49792 164 2.85e-06 30 7 3 0.429 0.100 REAC:168274 rea 1 Export of Viral Ribonucleoproteins from Nucleus 1 Q9UKX7,P49790,P49792 164 2.85e-06 30 7 3 0.429 0.100 REAC:168333 rea 1 NEP/NS2 Interacts with the Cellular Export Machinery 1 Q9UKX7,P49790,P49792 164 2.85e-06 30 7 3 0.429 0.100 REAC:170822 rea 1 Regulation of Glucokinase by Glucokinase Regulatory Protein 1 Q9UKX7,P49790,P49792 164 2.85e-06 30 7 3 0.429 0.100 REAC:168271 rea 1 Transport of Ribonucleoproteins into the Host Nucleus 1 Q9UKX7,P49790,P49792 164 3.48e-06 32 7 3 0.429 0.094 REAC:180746 rea 1 Nuclear import of Rev protein 1 Q9UKX7,P49790,P49792 164 3.48e-06 32 7 3 0.429 0.094 REAC:159227 rea 1 Transport of the SLBP independent Mature mRNA 1 Q9UKX7,P49790,P49792 164 3.48e-06 32 7 3 0.429 0.094 REAC:180910 rea 1 Vpr-mediated nuclear import of PICs 1 Q9UKX7,P49790,P49792 164 3.66e-06 125 7 4 0.571 0.032 REAC:162909 rea 1 Host Interactions of HIV factors 1 Q9UKX7,P46060,P49790,P49792 164 3.83e-06 33 7 3 0.429 0.091 REAC:159230 rea 1 Transport of the SLBP Dependant Mature mRNA 1 Q9UKX7,P49790,P49792 164 3.89e-06 42 7 3 0.429 0.071 GO:0007077 BP 1 mitotic nuclear envelope disassembly 1 Q9UKX7,P49790,P49792 164 4.15e-06 129 7 4 0.571 0.031 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 Q9UKX7,P46060,P49790,P49792 164 4.20e-06 34 7 3 0.429 0.088 REAC:3301854 rea 1 Nuclear Pore Complex (NPC) Disassembly 1 Q9UKX7,P49790,P49792 164 4.48e-06 44 7 3 0.429 0.068 GO:0051081 BP 1 nuclear envelope disassembly 1 Q9UKX7,P49790,P49792 164 4.48e-06 44 7 3 0.429 0.068 GO:0030397 BP 1 membrane disassembly 1 Q9UKX7,P49790,P49792 164 4.59e-06 35 7 3 0.429 0.086 REAC:176033 rea 1 Interactions of Vpr with host cellular proteins 1 Q9UKX7,P49790,P49792 164 5.44e-06 37 7 3 0.429 0.081 REAC:159231 rea 1 Transport of Mature mRNA Derived from an Intronless Transcript 1 Q9UKX7,P49790,P49792 164 5.76e-06 140 7 4 0.571 0.029 REAC:162587 rea 1 HIV Life Cycle 1 Q9UKX7,P46060,P49790,P49792 164 5.91e-06 38 7 3 0.429 0.079 REAC:159234 rea 1 Transport of Mature mRNAs Derived from Intronless Transcripts 1 Q9UKX7,P49790,P49792 164 6.40e-06 39 7 3 0.429 0.077 REAC:70153 rea 1 Glucose transport 1 Q9UKX7,P49790,P49792 164 6.40e-06 39 7 3 0.429 0.077 REAC:168276 rea 1 NS1 Mediated Effects on Host Pathways 1 Q9UKX7,P49790,P49792 164 7.45e-06 41 7 3 0.429 0.073 REAC:168253 rea 1 Host Interactions with Influenza Factors 1 Q9UKX7,P49790,P49792 164 8.02e-06 42 7 3 0.429 0.071 REAC:168325 rea 1 Viral Messenger RNA Synthesis 1 Q9UKX7,P49790,P49792 164 8.62e-06 43 7 3 0.429 0.070 REAC:189200 rea 1 Hexose transport 1 Q9UKX7,P49790,P49792 164 9.91e-06 45 7 3 0.429 0.067 REAC:4570464 rea 1 SUMOylation of RNA binding proteins 1 Q9UKX7,P49790,P49792 164 1.04e-05 58 7 3 0.429 0.052 GO:0010827 BP 1 regulation of glucose transport 1 Q9UKX7,P49790,P49792 164 1.37e-05 50 7 3 0.429 0.060 REAC:191859 rea 1 snRNP Assembly 1 Q9UKX7,P49790,P49792 164 1.37e-05 50 7 3 0.429 0.060 REAC:2980766 rea 1 Nuclear Envelope Breakdown 1 Q9UKX7,P49790,P49792 164 1.37e-05 50 7 3 0.429 0.060 REAC:194441 rea 1 Metabolism of non-coding RNA 1 Q9UKX7,P49790,P49792 164 1.47e-05 65 7 3 0.429 0.046 GO:0075733 BP 1 intracellular transport of virus 1 Q9UKX7,P49790,P49792 164 1.54e-05 66 7 3 0.429 0.045 GO:1902583 BP 1 multi-organism intracellular transport 1 Q9UKX7,P49790,P49792 164 1.54e-05 66 7 3 0.429 0.045 GO:1902581 BP 1 multi-organism cellular localization 1 Q9UKX7,P49790,P49792 164 1.61e-05 67 7 3 0.429 0.045 GO:0046794 BP 1 transport of virus 1 Q9UKX7,P49790,P49792 164 1.66e-05 7 7 2 0.286 0.286 GO:0044615 CC 1 nuclear pore nuclear basket 1 P49790,P49792 164 1.69e-05 68 7 3 0.429 0.044 GO:0006998 BP 1 nuclear envelope organization 1 Q9UKX7,P49790,P49792 164 1.82e-05 55 7 3 0.429 0.055 REAC:6784531 rea 1 tRNA processing in the nucleus 1 Q9UKX7,P49790,P49792 164 1.84e-05 70 7 3 0.429 0.043 GO:1902579 BP 1 multi-organism localization 1 Q9UKX7,P49790,P49792 164 1.84e-05 70 7 3 0.429 0.043 GO:0044766 BP 1 multi-organism transport 1 Q9UKX7,P49790,P49792 164 2.09e-05 73 7 3 0.429 0.041 GO:1900034 BP 1 regulation of cellular response to heat 1 Q9UKX7,P49790,P49792 164 2.26e-05 59 7 3 0.429 0.051 REAC:5578749 rea 1 Transcriptional regulation by small RNAs 1 Q9UKX7,P49790,P49792 164 2.55e-05 78 7 3 0.429 0.038 GO:0015758 BP 1 glucose transport 1 Q9UKX7,P49790,P49792 164 2.55e-05 78 7 3 0.429 0.038 GO:0008645 BP 1 hexose transport 1 Q9UKX7,P49790,P49792 164 2.65e-05 79 7 3 0.429 0.038 GO:0015749 BP 1 monosaccharide transport 1 Q9UKX7,P49790,P49792 164 2.99e-05 665 7 5 0.714 0.008 GO:0031967 CC 1 organelle envelope 1 Q9UKX7,P46060,P49790,P49792,O14715 164 3.06e-05 668 7 5 0.714 0.007 GO:0031975 CC 1 envelope 1 Q9UKX7,P46060,P49790,P49792,O14715 164 3.08e-05 83 7 3 0.429 0.036 GO:0008643 BP 1 carbohydrate transport 1 Q9UKX7,P49790,P49792 164 3.17e-05 66 7 3 0.429 0.045 REAC:1169408 rea 1 ISG15 antiviral mechanism 1 Q9UKX7,P49790,P49792 164 3.17e-05 66 7 3 0.429 0.045 REAC:1169410 rea 1 Antiviral mechanism by IFN-stimulated genes 1 Q9UKX7,P49790,P49792 164 3.31e-05 85 7 3 0.429 0.035 GO:0034605 BP 1 cellular response to heat 1 Q9UKX7,P49790,P49792 164 3.41e-05 219 7 4 0.571 0.018 REAC:162906 rea 1 HIV Infection 1 Q9UKX7,P46060,P49790,P49792 164 3.47e-05 68 7 3 0.429 0.044 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 Q9UKX7,P49790,P49792 164 3.50e-05 296 7 4 0.571 0.014 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9UKX7,P46060,P49790,P49792 164 4.33e-05 11 7 2 0.286 0.182 GO:0042405 CC 1 nuclear inclusion body 1 P49790,P49792 164 4.65e-05 318 7 4 0.571 0.013 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q9UKX7,P46060,P49790,P49792 164 4.66e-05 75 7 3 0.429 0.040 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 Q9UKX7,P49790,P49792 164 4.66e-05 75 7 3 0.429 0.040 REAC:3108214 rea 1 SUMOylation of DNA damage response and repair proteins 1 Q9UKX7,P49790,P49792 164 4.66e-05 75 7 3 0.429 0.040 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 Q9UKX7,P49790,P49792 164 5.00e-05 324 7 4 0.571 0.012 GO:0051169 BP 1 nuclear transport 1 Q9UKX7,P46060,P49790,P49792 164 5.40e-05 100 7 3 0.429 0.030 GO:0006406 BP 1 mRNA export from nucleus 1 Q9UKX7,P49790,P49792 164 5.40e-05 100 7 3 0.429 0.030 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q9UKX7,P49790,P49792 164 5.40e-05 100 7 3 0.429 0.030 GO:0009408 BP 1 response to heat 1 Q9UKX7,P49790,P49792 164 5.90e-05 103 7 3 0.429 0.029 GO:0006997 BP 1 nucleus organization 1 Q9UKX7,P49790,P49792 164 6.03e-05 253 7 4 0.571 0.016 REAC:68886 rea 1 M Phase 1 Q9UKX7,P46060,P49790,P49792 164 6.07e-05 104 7 3 0.429 0.029 GO:0051028 BP 1 mRNA transport 1 Q9UKX7,P49790,P49792 164 7.02e-05 86 7 3 0.429 0.035 REAC:211000 rea 1 Gene Silencing by RNA 1 Q9UKX7,P49790,P49792 164 7.18e-05 110 7 3 0.429 0.027 GO:0031047 BP 1 gene silencing by RNA 1 Q9UKX7,P49790,P49792 164 7.38e-05 111 7 3 0.429 0.027 GO:0006405 BP 1 RNA export from nucleus 1 Q9UKX7,P49790,P49792 164 7.58e-05 112 7 3 0.429 0.027 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q9UKX7,P49790,P49792 164 8.21e-05 115 7 3 0.429 0.026 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q9UKX7,P49790,P49792 164 8.32e-05 91 7 3 0.429 0.033 REAC:3371556 rea 1 Cellular response to heat stress 1 Q9UKX7,P49790,P49792 164 8.88e-05 93 7 3 0.429 0.032 REAC:68875 rea 1 Mitotic Prophase 1 Q9UKX7,P49790,P49792 164 9.09e-05 119 7 3 0.429 0.025 GO:0009266 BP 1 response to temperature stimulus 1 Q9UKX7,P49790,P49792 164 1.05e-04 125 7 3 0.429 0.024 GO:0050658 BP 1 RNA transport 1 Q9UKX7,P49790,P49792 164 1.05e-04 125 7 3 0.429 0.024 GO:0050657 BP 1 nucleic acid transport 1 Q9UKX7,P49790,P49792 164 1.13e-04 128 7 3 0.429 0.023 GO:0051236 BP 1 establishment of RNA localization 1 Q9UKX7,P49790,P49792 164 1.54e-04 142 7 3 0.429 0.021 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q9UKX7,P49790,P49792 164 1.59e-04 113 7 3 0.429 0.027 REAC:72306 rea 1 tRNA processing 1 Q9UKX7,P49790,P49792 164 1.73e-04 952 7 5 0.714 0.005 GO:0022402 BP 1 cell cycle process 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 2.06e-04 346 7 4 0.571 0.012 REAC:5663205 rea 1 Infectious disease 1 Q9UKX7,P46060,P49790,P49792 164 2.12e-04 158 7 3 0.429 0.019 GO:0006403 BP 1 RNA localization 1 Q9UKX7,P49790,P49792 164 2.37e-04 164 7 3 0.429 0.018 GO:0019083 BP 1 viral transcription 1 Q9UKX7,P49790,P49792 164 2.41e-04 165 7 3 0.429 0.018 GO:0016458 BP 1 gene silencing 1 Q9UKX7,P49790,P49792 164 2.50e-04 167 7 3 0.429 0.018 GO:0006606 BP 1 protein import into nucleus 1 Q9UKX7,P49790,P49792 164 2.50e-04 167 7 3 0.429 0.018 GO:0044744 BP 1 protein targeting to nucleus 1 Q9UKX7,P49790,P49792 164 2.50e-04 167 7 3 0.429 0.018 GO:1902593 BP 1 single-organism nuclear import 1 Q9UKX7,P49790,P49792 164 2.52e-04 132 7 3 0.429 0.023 REAC:168273 rea 1 Influenza Viral RNA Transcription and Replication 1 Q9UKX7,P49790,P49792 164 2.59e-04 169 7 3 0.429 0.018 GO:0017016 MF 1 Ras GTPase binding 1 Q9UKX7,P49792,O14715 164 2.87e-04 175 7 3 0.429 0.017 GO:0019080 BP 1 viral gene expression 1 Q9UKX7,P49790,P49792 164 3.00e-04 140 7 3 0.429 0.021 REAC:168255 rea 1 Influenza Life Cycle 1 Q9UKX7,P49790,P49792 164 3.33e-04 184 7 3 0.429 0.016 GO:0031267 MF 1 small GTPase binding 1 Q9UKX7,P49792,O14715 164 3.33e-04 184 7 3 0.429 0.016 GO:0051170 BP 1 nuclear import 1 Q9UKX7,P49790,P49792 164 3.54e-04 148 7 3 0.429 0.020 REAC:913531 rea 1 Interferon Signaling 1 Q9UKX7,P49790,P49792 164 3.76e-04 151 7 3 0.429 0.020 REAC:168254 rea 1 Influenza Infection 1 Q9UKX7,P49790,P49792 164 3.84e-04 193 7 3 0.429 0.016 GO:0044033 BP 1 multi-organism metabolic process 1 Q9UKX7,P49790,P49792 164 3.93e-04 1128 7 5 0.714 0.004 GO:0007049 BP 1 cell cycle 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 4.02e-04 196 7 3 0.429 0.015 GO:0000819 BP 1 sister chromatid segregation 1 P46060,P49792,Q9BW19 164 4.33e-04 201 7 3 0.429 0.015 GO:0051020 MF 1 GTPase binding 1 Q9UKX7,P49792,O14715 164 4.68e-04 573 7 4 0.571 0.007 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q9UKX7,P46060,P49790,P49792 164 4.79e-04 208 7 3 0.429 0.014 GO:0017038 BP 1 protein import 1 Q9UKX7,P49790,P49792 164 5.29e-04 2096 7 6 0.857 0.003 GO:0043234 CC 1 protein complex 1 Q9UKX7,P46060,P49790,P49792,O14715,Q9BW19 164 5.60e-04 448 7 4 0.571 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q9UKX7,P46060,P49790,P49792 164 5.74e-04 221 7 3 0.429 0.014 GO:0034504 BP 1 protein localization to nucleus 1 Q9UKX7,P49790,P49792 164 6.13e-04 226 7 3 0.429 0.013 GO:0098813 BP 1 nuclear chromosome segregation 1 P46060,P49792,Q9BW19 164 6.31e-04 180 7 3 0.429 0.017 REAC:425407 rea 1 SLC-mediated transmembrane transport 1 Q9UKX7,P49790,P49792 164 7.95e-04 657 7 4 0.571 0.006 GO:1903047 BP 1 mitotic cell cycle process 1 Q9UKX7,P49790,P49792,Q9BW19 164 8.07e-04 46 7 2 0.286 0.043 GO:0046823 BP 1 negative regulation of nucleocytoplasmic transport 1 P46060,P49790 164 8.18e-04 662 7 4 0.571 0.006 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q9UKX7,P46060,P49790,P49792 164 9.58e-04 263 7 3 0.429 0.011 GO:0007059 BP 1 chromosome segregation 1 P46060,P49792,Q9BW19 164 1.07e-03 709 7 4 0.571 0.006 GO:0006886 BP 1 intracellular protein transport 1 Q9UKX7,P46060,P49790,P49792 164 1.11e-03 54 7 2 0.286 0.037 GO:0016234 CC 1 inclusion body 1 P49790,P49792 164 1.13e-03 720 7 4 0.571 0.006 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9UKX7,P46060,P49790,P49792 164 1.14e-03 721 7 4 0.571 0.006 GO:0000278 BP 1 mitotic cell cycle 1 Q9UKX7,P49790,P49792,Q9BW19 164 1.21e-03 547 7 4 0.571 0.007 REAC:1640170 rea 1 Cell Cycle 1 Q9UKX7,P46060,P49790,P49792 164 1.26e-03 228 7 3 0.429 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q9UKX7,P49790,P49792 164 1.51e-03 1493 7 5 0.714 0.003 GO:0051649 BP 1 establishment of localization in cell 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 1.57e-03 246 7 3 0.429 0.012 REAC:71387 rea 1 Metabolism of carbohydrates 1 Q9UKX7,P49790,P49792 164 1.66e-03 66 7 2 0.286 0.030 GO:0032387 BP 1 negative regulation of intracellular transport 1 P46060,P49790 164 2.05e-03 341 7 3 0.429 0.009 GO:0019058 BP 1 viral life cycle 1 Q9UKX7,P49790,P49792 164 2.66e-03 373 7 3 0.429 0.008 GO:0016032 BP 1 viral process 1 Q9UKX7,P49790,P49792 164 2.68e-03 374 7 3 0.429 0.008 GO:0071705 BP 1 nitrogen compound transport 1 Q9UKX7,P49790,P49792 164 2.71e-03 375 7 3 0.429 0.008 GO:0044764 BP 1 multi-organism cellular process 1 Q9UKX7,P49790,P49792 164 2.94e-03 386 7 3 0.429 0.008 GO:0044419 BP 1 interspecies interaction between organisms 1 Q9UKX7,P49790,P49792 164 2.94e-03 386 7 3 0.429 0.008 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q9UKX7,P49790,P49792 164 3.03e-03 2 7 1 0.143 0.500 GO:0032240 BP 1 negative regulation of nucleobase-containing compound transport 1 P49790 164 3.03e-03 2 7 1 0.143 0.500 GO:0090526 BP 1 regulation of gluconeogenesis involved in cellular glucose homeostasis 1 P49792 164 3.03e-03 2 7 1 0.143 0.500 GO:0046832 BP 1 negative regulation of RNA export from nucleus 1 P49790 164 3.09e-03 936 7 4 0.571 0.004 GO:0051049 BP 1 regulation of transport 1 Q9UKX7,P46060,P49790,P49792 164 3.27e-03 712 7 4 0.571 0.006 REAC:597592 rea 1 Post-translational protein modification 1 Q9UKX7,P46060,P49790,P49792 164 3.36e-03 404 7 3 0.429 0.007 GO:0080135 BP 1 regulation of cellular response to stress 1 Q9UKX7,P49790,P49792 164 3.36e-03 404 7 3 0.429 0.007 GO:0010256 BP 1 endomembrane system organization 1 Q9UKX7,P49790,P49792 164 3.41e-03 720 7 4 0.571 0.006 REAC:1643685 rea 1 Disease 1 Q9UKX7,P46060,P49790,P49792 164 3.45e-03 964 7 4 0.571 0.004 GO:0015031 BP 1 protein transport 1 Q9UKX7,P46060,P49790,P49792 164 3.92e-03 426 7 3 0.429 0.007 GO:0022411 BP 1 cellular component disassembly 1 Q9UKX7,P49790,P49792 164 4.02e-03 1836 7 5 0.714 0.003 GO:0051641 BP 1 cellular localization 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 4.47e-03 446 7 3 0.429 0.007 GO:0051276 BP 1 chromosome organization 1 P46060,P49792,Q9BW19 164 4.55e-03 3 7 1 0.143 0.333 GO:1903300 BP 1 negative regulation of hexokinase activity 1 P49792 164 4.55e-03 3 7 1 0.143 0.333 GO:0033132 BP 1 negative regulation of glucokinase activity 1 P49792 164 4.55e-03 3 7 1 0.143 0.333 GO:0044614 CC 1 nuclear pore cytoplasmic filaments 1 P49792 164 4.58e-03 624 7 4 0.571 0.006 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 4.76e-03 99 7 2 0.286 0.020 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 P46060,P49792 164 5.09e-03 116 7 2 0.286 0.017 GO:0007062 BP 1 sister chromatid cohesion 1 P46060,P49792 164 5.18e-03 117 7 2 0.286 0.017 GO:0005875 CC 1 microtubule associated complex 1 P49792,Q9BW19 164 5.42e-03 378 7 3 0.429 0.008 REAC:2262752 rea 1 Cellular responses to stress 1 Q9UKX7,P49790,P49792 164 5.54e-03 107 7 2 0.286 0.019 REAC:68877 rea 1 Mitotic Prometaphase 1 P46060,P49792 164 5.63e-03 122 7 2 0.286 0.016 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 P46060,P49790 164 5.69e-03 1100 7 4 0.571 0.004 GO:0045184 BP 1 establishment of protein localization 1 Q9UKX7,P46060,P49790,P49792 164 5.70e-03 485 7 3 0.429 0.006 GO:0072594 BP 1 establishment of protein localization to organelle 1 Q9UKX7,P49790,P49792 164 5.73e-03 3168 7 6 0.857 0.002 GO:0044428 CC 1 nuclear part 1 Q9UKX7,P46060,P49790,P49792,O14715,Q69YH5 164 5.76e-03 487 7 3 0.429 0.006 GO:0006605 BP 1 protein targeting 1 Q9UKX7,P49790,P49792 164 5.90e-03 1111 7 4 0.571 0.004 GO:0034613 BP 1 cellular protein localization 1 Q9UKX7,P46060,P49790,P49792 164 6.06e-03 4 7 1 0.143 0.250 GO:0046826 BP 1 negative regulation of protein export from nucleus 1 P46060 164 6.10e-03 1121 7 4 0.571 0.004 GO:0070727 BP 1 cellular macromolecule localization 1 Q9UKX7,P46060,P49790,P49792 164 6.17e-03 113 7 2 0.286 0.018 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 P46060,P49792 164 6.92e-03 519 7 3 0.429 0.006 GO:0009628 BP 1 response to abiotic stimulus 1 Q9UKX7,P49790,P49792 164 7.23e-03 1360 7 5 0.714 0.004 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 7.58e-03 5 7 1 0.143 0.200 GO:0043495 MF 1 protein anchor 1 P49790 164 7.58e-03 5 7 1 0.143 0.200 GO:0033131 BP 1 regulation of glucokinase activity 1 P49792 164 8.18e-03 1396 7 5 0.714 0.004 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 8.65e-03 446 7 3 0.429 0.007 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 Q9UKX7,P49790,P49792 164 8.77e-03 3415 7 6 0.857 0.002 GO:0032991 CC 1 macromolecular complex 1 Q9UKX7,P46060,P49790,P49792,O14715,Q9BW19 164 8.82e-03 1237 7 4 0.571 0.003 GO:0046907 BP 1 intracellular transport 1 Q9UKX7,P46060,P49790,P49792 164 9.09e-03 6 7 1 0.143 0.167 GO:1903299 BP 1 regulation of hexokinase activity 1 P49792 164 9.09e-03 6 7 1 0.143 0.167 GO:0044613 CC 1 nuclear pore central transport channel 1 P49790 164 9.23e-03 574 7 3 0.429 0.005 GO:1902582 BP 1 single-organism intracellular transport 1 Q9UKX7,P49790,P49792 164 9.38e-03 246 7 2 0.286 0.008 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 O14715,Q69YH5 164 9.43e-03 753 7 4 0.571 0.005 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 1.05e-02 775 7 4 0.571 0.005 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 1.06e-02 2260 7 5 0.714 0.002 GO:0012505 CC 1 endomembrane system 1 Q9UKX7,P46060,P49790,P49792,O14715 164 1.06e-02 2262 7 5 0.714 0.002 GO:0006996 BP 1 organelle organization 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 1.09e-02 2275 7 5 0.714 0.002 GO:0036211 BP 1 protein modification process 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 1.09e-02 2275 7 5 0.714 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 1.15e-02 493 7 3 0.429 0.006 REAC:382551 rea 1 Transmembrane transport of small molecules 1 Q9UKX7,P49790,P49792 164 1.19e-02 1340 7 4 0.571 0.003 GO:0032879 BP 1 regulation of localization 1 Q9UKX7,P46060,P49790,P49792 164 1.20e-02 1513 7 5 0.714 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 1.20e-02 630 7 3 0.429 0.005 GO:0044802 BP 1 single-organism membrane organization 1 Q9UKX7,P49790,P49792 164 1.23e-02 161 7 2 0.286 0.012 REAC:2467813 rea 1 Separation of Sister Chromatids 1 P46060,P49792 164 1.31e-02 1377 7 4 0.571 0.003 GO:0071702 BP 1 organic substance transport 1 Q9UKX7,P46060,P49790,P49792 164 1.31e-02 650 7 3 0.429 0.005 GO:0051704 BP 1 multi-organism process 1 Q9UKX7,P49790,P49792 164 1.35e-02 657 7 3 0.429 0.005 GO:0033365 BP 1 protein localization to organelle 1 Q9UKX7,P49790,P49792 164 1.37e-02 1393 7 4 0.571 0.003 GO:0008104 BP 1 protein localization 1 Q9UKX7,P46060,P49790,P49792 164 1.40e-02 172 7 2 0.286 0.012 REAC:68882 rea 1 Mitotic Anaphase 1 P46060,P49792 164 1.41e-02 173 7 2 0.286 0.012 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 P46060,P49792 164 1.44e-02 2417 7 5 0.714 0.002 GO:0043412 BP 1 macromolecule modification 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 1.45e-02 1414 7 4 0.571 0.003 GO:0031090 CC 1 organelle membrane 1 Q9UKX7,P46060,P49790,P49792 164 1.51e-02 1589 7 5 0.714 0.003 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 1.51e-02 10 7 1 0.143 0.100 GO:0051292 BP 1 nuclear pore complex assembly 1 P49790 164 1.51e-02 10 7 1 0.143 0.100 GO:0046831 BP 1 regulation of RNA export from nucleus 1 P49790 164 1.66e-02 11 7 1 0.143 0.091 GO:0032239 BP 1 regulation of nucleobase-containing compound transport 1 P49790 164 1.69e-02 877 7 4 0.571 0.005 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792 164 1.80e-02 221 7 2 0.286 0.009 GO:0051051 BP 1 negative regulation of transport 1 P46060,P49790 164 1.82e-02 12 7 1 0.143 0.083 GO:0046931 BP 1 pore complex assembly 1 P49790 164 1.88e-02 902 7 4 0.571 0.004 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 1.96e-02 749 7 3 0.429 0.004 GO:0061024 BP 1 membrane organization 1 Q9UKX7,P49790,P49792 164 1.97e-02 913 7 4 0.571 0.004 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q9UKX7,P46060,P49790,P49792 164 2.00e-02 5787 7 7 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9UKX7,P46060,P49790,P49792,O14715,Q69YH5,Q9BW19 164 2.02e-02 1169 7 4 0.571 0.003 REAC:392499 rea 1 Metabolism of proteins 1 Q9UKX7,P46060,P49790,P49792 164 2.11e-02 930 7 4 0.571 0.004 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q9UKX7,P46060,P49792,Q9BW19 164 2.12e-02 14 7 1 0.143 0.071 GO:0019789 MF 1 SUMO transferase activity 1 P49792 164 2.12e-02 14 7 1 0.143 0.071 GO:0006999 BP 1 nuclear pore organization 1 P49790 164 2.12e-02 771 7 3 0.429 0.004 GO:1902580 BP 1 single-organism cellular localization 1 Q9UKX7,P49790,P49792 164 2.18e-02 938 7 4 0.571 0.004 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 2.19e-02 4308 7 7 1.000 0.002 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 Q9UKX7,P46060,P49790,P49792,O14715,Q69YH5,Q9BW19 164 2.22e-02 5877 7 7 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9UKX7,P46060,P49790,P49792,O14715,Q69YH5,Q9BW19 164 2.27e-02 15 7 1 0.143 0.067 GO:0017056 MF 1 structural constituent of nuclear pore 1 P49790 164 2.36e-02 958 7 4 0.571 0.004 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792 164 2.37e-02 1618 7 4 0.571 0.002 GO:0033036 BP 1 macromolecule localization 1 Q9UKX7,P46060,P49790,P49792 164 2.42e-02 16 7 1 0.143 0.062 GO:0006111 BP 1 regulation of gluconeogenesis 1 P49792 164 2.42e-02 965 7 4 0.571 0.004 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 2.45e-02 231 7 2 0.286 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 P46060,P49792 164 2.47e-02 814 7 3 0.429 0.004 GO:0080134 BP 1 regulation of response to stress 1 Q9UKX7,P49790,P49792 164 2.54e-02 977 7 4 0.571 0.004 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 2.57e-02 17 7 1 0.143 0.059 GO:0035307 BP 1 positive regulation of protein dephosphorylation 1 Q69YH5 164 2.59e-02 2748 7 5 0.714 0.002 GO:0051234 BP 1 establishment of localization 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 2.60e-02 1782 7 5 0.714 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 2.79e-02 1002 7 4 0.571 0.004 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792 164 2.82e-02 1813 7 5 0.714 0.003 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 2.89e-02 861 7 3 0.429 0.003 GO:0010629 BP 1 negative regulation of gene expression 1 Q9UKX7,P49790,P49792 164 3.02e-02 20 7 1 0.143 0.050 GO:0046825 BP 1 regulation of protein export from nucleus 1 P46060 164 3.02e-02 20 7 1 0.143 0.050 GO:0035306 BP 1 positive regulation of dephosphorylation 1 Q69YH5 164 3.17e-02 21 7 1 0.143 0.048 GO:0010677 BP 1 negative regulation of cellular carbohydrate metabolic process 1 P49792 164 3.17e-02 21 7 1 0.143 0.048 GO:0006607 BP 1 NLS-bearing protein import into nucleus 1 P49792 164 3.20e-02 469 7 2 0.286 0.004 MI:hsa-let-7f mi 1 MI:hsa-let-7f 1 P49792,O14715 164 3.32e-02 22 7 1 0.143 0.045 GO:0008139 MF 1 nuclear localization sequence binding 1 P49790 164 3.46e-02 310 7 2 0.286 0.006 GO:0032386 BP 1 regulation of intracellular transport 1 P46060,P49790 164 3.47e-02 23 7 1 0.143 0.043 GO:0005487 MF 1 nucleocytoplasmic transporter activity 1 P49790 164 3.62e-02 24 7 1 0.143 0.042 GO:0045912 BP 1 negative regulation of carbohydrate metabolic process 1 P49792 164 3.68e-02 1078 7 4 0.571 0.004 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 3.68e-02 1078 7 4 0.571 0.004 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 3.69e-02 507 7 2 0.286 0.004 MI:hsa-miR-141 mi 1 MI:hsa-miR-141 1 O14715,Q69YH5 164 3.76e-02 4430 7 6 0.857 0.001 GO:0005634 CC 1 nucleus 1 Q9UKX7,P46060,P49790,P49792,O14715,Q69YH5 164 3.78e-02 2990 7 5 0.714 0.002 GO:0044267 BP 1 cellular protein metabolic process 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 3.79e-02 1932 7 5 0.714 0.003 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 3.85e-02 1091 7 4 0.571 0.004 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792 164 3.87e-02 1941 7 5 0.714 0.003 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 3.97e-02 1100 7 4 0.571 0.004 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792 164 4.06e-02 534 7 2 0.286 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 P46060,P49792 164 4.19e-02 1974 7 5 0.714 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 4.21e-02 505 7 3 0.429 0.006 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q9UKX7,P46060,P49790 164 4.41e-02 1996 7 5 0.714 0.003 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 4.43e-02 1133 7 4 0.571 0.004 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q9UKX7,P46060,P49790,P49792 164 4.72e-02 2026 7 5 0.714 0.002 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 4.86e-02 531 7 3 0.429 0.006 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q9UKX7,P49790,P49792 164 4.98e-02 41 7 1 0.143 0.024 REAC:983189 rea 1 Kinesins 1 Q9BW19 164 5.00e-02 152 7 5 0.714 0.033 KEGG:03013 keg 1 RNA transport 1 Q9UKX7,P46060,P49790,P49792,O14715 164 5.00e-02 338 7 2 0.286 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 P46060,P49792 164 5.00e-02 1 7 1 0.143 1.000 OMIM:608033 omi 1 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3; IIAE3;;ENCEPHALOPATHY, ACUTE NECROTIZING, SUSCEPTIBILITY TO; ANE 1 P49792 164 5.00e-02 3185 7 5 0.714 0.002 GO:0019538 BP 1 protein metabolic process 1 Q9UKX7,P46060,P49790,P49792,Q69YH5 164 5.00e-02 2051 7 5 0.714 0.002 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q9UKX7,P46060,P49790,P49792,Q9BW19 164 5.00e-02 2068 7 6 0.857 0.003 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 Q9UKX7,P49790,P49792,O14715,Q69YH5,Q9BW19 165 1.34e-03 2 2 1 0.500 0.500 GO:0044393 CC 1 microspike 1 Q16658 165 2.01e-03 3 2 1 0.500 0.333 GO:0030035 BP 1 microspike assembly 1 Q16658 165 2.67e-03 4 2 1 0.500 0.250 GO:0071803 BP 1 positive regulation of podosome assembly 1 Q16658 165 3.34e-03 5 2 1 0.500 0.200 GO:0032534 BP 1 regulation of microvillus assembly 1 Q16658 165 4.01e-03 6 2 1 0.500 0.167 GO:0090091 BP 1 positive regulation of extracellular matrix disassembly 1 Q16658 165 4.68e-03 7 2 1 0.500 0.143 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 Q6UXN9 165 4.68e-03 7 2 1 0.500 0.143 GO:0071437 CC 1 invadopodium 1 Q16658 165 4.68e-03 7 2 1 0.500 0.143 GO:0035089 BP 1 establishment of apical/basal cell polarity 1 Q16658 165 5.35e-03 8 2 1 0.500 0.125 GO:0061162 BP 1 establishment of monopolar cell polarity 1 Q16658 165 5.35e-03 8 2 1 0.500 0.125 GO:0032530 BP 1 regulation of microvillus organization 1 Q16658 165 6.02e-03 9 2 1 0.500 0.111 GO:0010592 BP 1 positive regulation of lamellipodium assembly 1 Q16658 165 6.02e-03 9 2 1 0.500 0.111 GO:0061339 BP 1 establishment or maintenance of monopolar cell polarity 1 Q16658 165 6.02e-03 9 2 1 0.500 0.111 GO:0071801 BP 1 regulation of podosome assembly 1 Q16658 165 6.69e-03 10 2 1 0.500 0.100 GO:0048188 CC 1 Set1C/COMPASS complex 1 Q6UXN9 165 7.35e-03 11 2 1 0.500 0.091 GO:0002102 CC 1 podosome 1 Q16658 165 8.69e-03 13 2 1 0.500 0.077 GO:0010715 BP 1 regulation of extracellular matrix disassembly 1 Q16658 165 8.69e-03 13 2 1 0.500 0.077 GO:1903055 BP 1 positive regulation of extracellular matrix organization 1 Q16658 165 9.36e-03 14 2 1 0.500 0.071 GO:0071800 BP 1 podosome assembly 1 Q16658 165 1.00e-02 15 2 1 0.500 0.067 GO:0051491 BP 1 positive regulation of filopodium assembly 1 Q16658 165 1.07e-02 16 2 1 0.500 0.062 GO:0042800 MF 1 histone methyltransferase activity (H3-K4 specific) 1 Q6UXN9 165 1.14e-02 17 2 1 0.500 0.059 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 Q16658 165 1.14e-02 17 2 1 0.500 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 Q16658 165 1.20e-02 18 2 1 0.500 0.056 GO:0030033 BP 1 microvillus assembly 1 Q16658 165 1.40e-02 21 2 1 0.500 0.048 GO:0032528 BP 1 microvillus organization 1 Q16658 165 1.40e-02 21 2 1 0.500 0.048 GO:0031941 CC 1 filamentous actin 1 Q16658 165 1.54e-02 23 2 1 0.500 0.043 GO:0035088 BP 1 establishment or maintenance of apical/basal cell polarity 1 Q16658 165 1.54e-02 23 2 1 0.500 0.043 GO:1903053 BP 1 regulation of extracellular matrix organization 1 Q16658 165 1.54e-02 23 2 1 0.500 0.043 GO:0061245 BP 1 establishment or maintenance of bipolar cell polarity 1 Q16658 165 1.80e-02 27 2 1 0.500 0.037 GO:0051489 BP 1 regulation of filopodium assembly 1 Q16658 165 1.80e-02 27 2 1 0.500 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q16658 165 1.94e-02 29 2 1 0.500 0.034 GO:0005902 CC 1 microvillus 1 Q16658 165 2.07e-02 31 2 1 0.500 0.032 GO:0001725 CC 1 stress fiber 1 Q16658 165 2.07e-02 31 2 1 0.500 0.032 GO:0030032 BP 1 lamellipodium assembly 1 Q16658 165 2.07e-02 31 2 1 0.500 0.032 GO:0097517 CC 1 contractile actin filament bundle 1 Q16658 165 2.20e-02 33 2 1 0.500 0.030 GO:0051568 BP 1 histone H3-K4 methylation 1 Q6UXN9 165 2.27e-02 34 2 1 0.500 0.029 GO:0032432 CC 1 actin filament bundle 1 Q16658 165 2.40e-02 36 2 1 0.500 0.028 GO:0018024 MF 1 histone-lysine N-methyltransferase activity 1 Q6UXN9 165 2.40e-02 36 2 1 0.500 0.028 GO:0008287 CC 1 protein serine/threonine phosphatase complex 1 Q6UXN9 165 2.40e-02 36 2 1 0.500 0.028 GO:1903293 CC 1 phosphatase complex 1 Q6UXN9 165 2.47e-02 37 2 1 0.500 0.027 GO:0046847 BP 1 filopodium assembly 1 Q16658 165 2.47e-02 37 2 1 0.500 0.027 GO:0042641 CC 1 actomyosin 1 Q16658 165 2.54e-02 38 2 1 0.500 0.026 GO:1902117 BP 1 positive regulation of organelle assembly 1 Q16658 165 2.62e-02 3 2 1 0.500 0.333 TF:M05774_0 tf 1 Factor: ZNF697; motif: KGGTACGAGGGM; match class: 0 1 Q16658 165 2.80e-02 42 2 1 0.500 0.024 GO:0097581 BP 1 lamellipodium organization 1 Q16658 165 2.94e-02 44 2 1 0.500 0.023 GO:0016279 MF 1 protein-lysine N-methyltransferase activity 1 Q6UXN9 165 3.00e-02 45 2 1 0.500 0.022 GO:0016278 MF 1 lysine N-methyltransferase activity 1 Q6UXN9 165 3.00e-02 45 2 1 0.500 0.022 GO:0030175 CC 1 filopodium 1 Q16658 165 3.20e-02 48 2 1 0.500 0.021 GO:0042054 MF 1 histone methyltransferase activity 1 Q6UXN9 165 3.34e-02 50 2 1 0.500 0.020 GO:0030426 CC 1 growth cone 1 Q16658 165 3.47e-02 52 2 1 0.500 0.019 GO:0008144 MF 1 drug binding 1 Q16658 165 3.54e-02 53 2 1 0.500 0.019 GO:0030427 CC 1 site of polarized growth 1 Q16658 165 3.67e-02 55 2 1 0.500 0.018 GO:0007043 BP 1 cell-cell junction assembly 1 Q16658 165 3.68e-02 328 2 2 1.000 0.006 TF:M00179_1 tf 1 Factor: ATF2; motif: VGTGACGTMACN; match class: 1 1 Q16658,Q6UXN9 165 3.74e-02 56 2 1 0.500 0.018 GO:0034968 BP 1 histone lysine methylation 1 Q6UXN9 165 3.94e-02 59 2 1 0.500 0.017 GO:0005884 CC 1 actin filament 1 Q16658 165 4.20e-02 63 2 1 0.500 0.016 GO:0030010 BP 1 establishment of cell polarity 1 Q16658 165 4.34e-02 65 2 1 0.500 0.015 GO:0018022 BP 1 peptidyl-lysine methylation 1 Q6UXN9 165 4.53e-02 68 2 1 0.500 0.015 GO:0008276 MF 1 protein methyltransferase activity 1 Q6UXN9 165 4.53e-02 68 2 1 0.500 0.015 GO:0035097 CC 1 histone methyltransferase complex 1 Q6UXN9 165 4.73e-02 71 2 1 0.500 0.014 GO:0022617 BP 1 extracellular matrix disassembly 1 Q16658 165 4.80e-02 72 2 1 0.500 0.014 GO:0008170 MF 1 N-methyltransferase activity 1 Q6UXN9 165 4.80e-02 72 2 1 0.500 0.014 GO:0016571 BP 1 histone methylation 1 Q6UXN9 165 5.00e-02 6 2 1 0.500 0.167 CORUM:2731 cor 1 Set1A complex 1 Q6UXN9 165 5.00e-02 75 2 1 0.500 0.013 GO:0098858 CC 1 actin-based cell projection 1 Q16658 165 5.00e-02 382 2 2 1.000 0.005 TF:M07246_1 tf 1 Factor: ATF-4; motif: NNTKRCRTCANS; match class: 1 1 Q16658,Q6UXN9 165 5.00e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 Q6UXN9 165 5.00e-02 6 2 1 0.500 0.167 CORUM:2730 cor 1 Set1B complex 1 Q6UXN9 166 7.93e-03 418 4 2 0.500 0.005 MI:hsa-miR-655 mi 1 MI:hsa-miR-655 1 Q92598,Q13564 166 1.20e-02 6 4 1 0.250 0.167 REAC:3000484 rea 1 Scavenging by Class F Receptors 1 Q92598 166 1.39e-02 16 4 1 0.250 0.062 TF:M06599_0 tf 1 Factor: ZNF480; motif: NGGTTCYGAAGA; match class: 0 1 Q13564 166 1.55e-02 397 4 2 0.500 0.005 TF:M05622_0 tf 1 Factor: HKR1; motif: GWNGTGSGRA; match class: 0 1 O75896,Q92598 166 1.56e-02 3483 4 4 1.000 0.001 TF:M07266_1 tf 1 Factor: p300; motif: CTGNCTYMAN; match class: 1 1 O00507,O75896,Q92598,Q13564 166 1.87e-02 1565 4 3 0.750 0.002 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 O00507,Q92598,Q13564 166 1.91e-02 658 4 2 0.500 0.003 MI:mmu-miR-466g mi 1 MI:mmu-miR-466g 1 Q92598,Q13564 166 2.09e-02 24 4 1 0.250 0.042 TF:M05699_0 tf 1 Factor: ZNF816A; motif: NGCWYAATAACA; match class: 0 1 Q13564 166 2.18e-02 25 4 1 0.250 0.040 TF:M06029_0 tf 1 Factor: ZNF197; motif: NATACCAYCATA; match class: 0 1 Q92598 166 2.27e-02 1673 4 3 0.750 0.002 TF:M07302_0 tf 1 Factor: NF-Y; motif: RGCCAATCRGN; match class: 0 1 O00507,O75896,Q92598 166 2.40e-02 496 4 2 0.500 0.004 TF:M02033_0 tf 1 Factor: TCF-4; motif: ATCAAAGNNN; match class: 0 1 O75896,Q13564 166 2.45e-02 3902 4 4 1.000 0.001 TF:M04068_0 tf 1 Factor: POU1F1; motif: NNNATGMATAWTTAATN; match class: 0 1 O00507,O75896,Q92598,Q13564 166 2.51e-02 3924 4 4 1.000 0.001 TF:M04318_0 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 0 1 O00507,O75896,Q92598,Q13564 166 2.52e-02 29 4 1 0.250 0.034 TF:M05304_1 tf 1 Factor: Zbtb5; motif: AGGRAGCTTC; match class: 1 1 O75896 166 2.96e-02 34 4 1 0.250 0.029 TF:M07222_1 tf 1 Factor: NFYA; motif: AGNSYKCTGATTGGTNNR; match class: 1 1 O00507 166 3.22e-02 1889 4 3 0.750 0.002 TF:M00775_0 tf 1 Factor: NF-Y; motif: NNNNRRCCAATSR; match class: 0 1 O00507,O75896,Q92598 166 3.33e-02 2 4 1 0.250 0.500 GO:0019781 MF 1 NEDD8 activating enzyme activity 1 Q13564 166 3.82e-02 44 4 1 0.250 0.023 TF:M07115_1 tf 1 Factor: NF-YB; motif: NNNYNRRCCAATCAG; match class: 1 1 O00507 166 4.17e-02 48 4 1 0.250 0.021 TF:M05921_0 tf 1 Factor: ZFP14; motif: KGGTGAAAAATA; match class: 0 1 Q13564 166 4.40e-02 22 4 1 0.250 0.045 REAC:3371568 rea 1 Attenuation phase 1 Q92598 166 4.60e-02 53 4 1 0.250 0.019 TF:M01241_1 tf 1 Factor: BEN; motif: CWGCGAYA; match class: 1 1 Q92598 166 4.94e-02 57 4 1 0.250 0.018 TF:M05299_0 tf 1 Factor: NKX2-6; motif: ACCGTTTTGT; match class: 0 1 O75896 166 5.00e-02 5 4 1 0.250 0.200 HP:0001450 hp 1 Y-linked inheritance 1 O00507 166 5.00e-02 1 4 1 0.250 1.000 OMIM:415000 omi 1 SPERMATOGENIC FAILURE, Y-LINKED, 2; SPGFY2;;SPERMATOGENIC FAILURE, NONOBSTRUCTIVE, Y-LINKED;;AZOOSPERMIA, NONOBSTRUCTIVE, Y-LINKED;;OLIGOZOOSPERMIA, NONOBSTRUCTIVE, Y-LINKED;;OLIGOSPERMIA, NONOBSTRUCTIVE, Y-LINKED;;SPERMATOGENIC ARREST, Y-LINKEDAZOOSPERMIA FACTOR REGIONS, INCLUDED;;AZF REGIONS, INCLUDED 1 O00507 166 5.00e-02 3 4 1 0.250 0.333 GO:0045343 BP 1 regulation of MHC class I biosynthetic process 1 Q92598 166 5.00e-02 25 4 1 0.250 0.040 REAC:3371511 rea 1 HSF1 activation 1 Q92598 166 5.00e-02 4663 4 4 1.000 0.001 TF:M00155_0 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 0 1 O00507,O75896,Q92598,Q13564 166 5.00e-02 3 4 1 0.250 0.333 GO:0045341 BP 1 MHC class I biosynthetic process 1 Q92598 166 5.00e-02 3 4 1 0.250 0.333 GO:0045345 BP 1 positive regulation of MHC class I biosynthetic process 1 Q92598 166 5.00e-02 2 4 1 0.250 0.500 CORUM:2162 cor 1 APPBP1-UBA3 complex 1 Q13564 167 3.93e-04 1 2 1 0.500 1.000 GO:0045128 BP 1 negative regulation of reciprocal meiotic recombination 1 P43246 167 3.93e-04 1 2 1 0.500 1.000 GO:0000406 MF 1 double-strand/single-strand DNA junction binding 1 P43246 167 4.01e-04 154 2 2 1.000 0.013 GO:0006302 BP 1 double-strand break repair 1 P46063,P43246 167 4.33e-04 160 2 2 1.000 0.013 GO:0006310 BP 1 DNA recombination 1 P46063,P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0032301 CC 1 MutSalpha complex 1 P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0000404 MF 1 heteroduplex DNA loop binding 1 P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0032143 MF 1 single thymine insertion binding 1 P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0032302 CC 1 MutSbeta complex 1 P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0032181 MF 1 dinucleotide repeat insertion binding 1 P43246 167 7.86e-04 2 2 1 0.500 0.500 GO:0000733 BP 1 DNA strand renaturation 1 P46063 167 7.86e-04 2 2 1 0.500 0.500 GO:0010520 BP 1 regulation of reciprocal meiotic recombination 1 P43246 167 1.18e-03 3 2 1 0.500 0.333 GO:0032137 MF 1 guanine/thymine mispair binding 1 P43246 167 1.18e-03 3 2 1 0.500 0.333 GO:0006311 BP 1 meiotic gene conversion 1 P43246 167 1.18e-03 3 2 1 0.500 0.333 GO:0060631 BP 1 regulation of meiosis I 1 P43246 167 1.18e-03 3 2 1 0.500 0.333 GO:0032142 MF 1 single guanine insertion binding 1 P43246 167 1.18e-03 3 2 1 0.500 0.333 GO:0032139 MF 1 dinucleotide insertion or deletion binding 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0032405 MF 1 MutLalpha complex binding 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0000403 MF 1 Y-form DNA binding 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0009378 MF 1 four-way junction helicase activity 1 P46063 167 1.57e-03 4 2 1 0.500 0.250 GO:0051447 BP 1 negative regulation of meiotic cell cycle 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0045835 BP 1 negative regulation of meiotic nuclear division 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0032138 MF 1 single base insertion or deletion binding 1 P43246 167 1.57e-03 4 2 1 0.500 0.250 GO:0035822 BP 1 gene conversion 1 P43246 167 1.73e-03 11 2 1 0.500 0.091 TF:M06373_0 tf 1 Factor: ZNF322A; motif: KGGGCCAAAYGW; match class: 0 1 P43246 167 1.96e-03 5 2 1 0.500 0.200 GO:0043140 MF 1 ATP-dependent 3'-5' DNA helicase activity 1 P46063 167 1.96e-03 5 2 1 0.500 0.200 GO:0032356 MF 1 oxidized DNA binding 1 P43246 167 1.96e-03 5 2 1 0.500 0.200 GO:0032357 MF 1 oxidized purine DNA binding 1 P43246 167 1.96e-03 5 2 1 0.500 0.200 GO:0043570 BP 1 maintenance of DNA repeat elements 1 P43246 167 2.13e-03 354 2 2 1.000 0.006 GO:0016887 MF 1 ATPase activity 1 P46063,P43246 167 2.36e-03 6 2 1 0.500 0.167 GO:0051096 BP 1 positive regulation of helicase activity 1 P43246 167 2.36e-03 6 2 1 0.500 0.167 GO:0032135 MF 1 DNA insertion or deletion binding 1 P43246 167 2.36e-03 6 2 1 0.500 0.167 GO:0032404 MF 1 mismatch repair complex binding 1 P43246 167 2.36e-03 6 2 1 0.500 0.167 GO:0000710 BP 1 meiotic mismatch repair 1 P43246 167 2.36e-03 6 2 1 0.500 0.167 GO:0036310 MF 1 annealing helicase activity 1 P46063 167 2.50e-03 384 2 2 1.000 0.005 GO:0006281 BP 1 DNA repair 1 P46063,P43246 167 2.75e-03 7 2 1 0.500 0.143 GO:0016446 BP 1 somatic hypermutation of immunoglobulin genes 1 P43246 167 2.75e-03 7 2 1 0.500 0.143 GO:0002566 BP 1 somatic diversification of immune receptors via somatic mutation 1 P43246 167 3.26e-03 727 2 2 1.000 0.003 TF:M04007_0 tf 1 Factor: HOMEZ; motif: AAAACGATTAWA; match class: 0 1 P46063,P43246 167 3.38e-03 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 P46063,P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:0030983 MF 1 mismatched DNA binding 1 P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:0051095 BP 1 regulation of helicase activity 1 P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:0010224 BP 1 response to UV-B 1 P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:0051445 BP 1 regulation of meiotic cell cycle 1 P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:2000242 BP 1 negative regulation of reproductive process 1 P43246 167 3.53e-03 9 2 1 0.500 0.111 GO:0040020 BP 1 regulation of meiotic nuclear division 1 P43246 167 3.71e-03 658 2 2 1.000 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P46063,P43246 167 3.93e-03 10 2 1 0.500 0.100 GO:0097617 MF 1 annealing activity 1 P46063 167 3.93e-03 10 2 1 0.500 0.100 GO:0032300 CC 1 mismatch repair complex 1 P43246 167 4.32e-03 11 2 1 0.500 0.091 GO:0031573 BP 1 intra-S DNA damage checkpoint 1 P43246 167 4.32e-03 11 2 1 0.500 0.091 GO:0045910 BP 1 negative regulation of DNA recombination 1 P43246 167 4.32e-03 11 2 1 0.500 0.091 GO:0043138 MF 1 3'-5' DNA helicase activity 1 P46063 167 4.56e-03 2 2 1 0.500 0.500 OMIM:158320 omi 1 MUIR-TORRE SYNDROME; MRTES;;CUTANEOUS SEBACEOUS NEOPLASMS AND KERATOACANTHOMAS, MULTIPLE, WITHGASTROINTESTINAL AND OTHER CARCINOMAS 1 P43246 167 4.57e-03 730 2 2 1.000 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 P46063,P43246 167 4.89e-03 755 2 2 1.000 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 P46063,P43246 167 5.10e-03 13 2 1 0.500 0.077 GO:0002208 BP 1 somatic diversification of immunoglobulins involved in immune response 1 P43246 167 5.10e-03 13 2 1 0.500 0.077 GO:0045190 BP 1 isotype switching 1 P43246 167 5.10e-03 13 2 1 0.500 0.077 GO:0002204 BP 1 somatic recombination of immunoglobulin genes involved in immune response 1 P43246 167 5.20e-03 553 2 2 1.000 0.004 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P46063,P43246 167 5.23e-03 781 2 2 1.000 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P46063,P43246 167 5.50e-03 14 2 1 0.500 0.071 GO:0000400 MF 1 four-way junction DNA binding 1 P43246 167 5.50e-03 14 2 1 0.500 0.071 GO:0016447 BP 1 somatic recombination of immunoglobulin gene segments 1 P43246 167 5.50e-03 14 2 1 0.500 0.071 GO:0010165 BP 1 response to X-ray 1 P43246 167 5.50e-03 14 2 1 0.500 0.071 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 P43246 167 5.57e-03 2 2 1 0.500 0.500 CORUM:374 cor 1 MSH2-MSH6 complex 1 P43246 167 5.57e-03 2 2 1 0.500 0.500 CORUM:2740 cor 1 MutS-alpha complex 1 P43246 167 5.57e-03 2 2 1 0.500 0.500 CORUM:375 cor 1 MSH2-MSH3 complex 1 P43246 167 5.57e-03 2 2 1 0.500 0.500 CORUM:1078 cor 1 MSH2-MSH6 complex 1 P43246 167 5.57e-03 2 2 1 0.500 0.500 CORUM:378 cor 1 MutS-beta complex 1 P43246 167 5.92e-03 590 2 2 1.000 0.003 GO:0016462 MF 1 pyrophosphatase activity 1 P46063,P43246 167 5.96e-03 592 2 2 1.000 0.003 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P46063,P43246 167 5.96e-03 592 2 2 1.000 0.003 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P46063,P43246 167 5.96e-03 592 2 2 1.000 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P46063,P43246 167 6.30e-03 609 2 2 1.000 0.003 GO:0005694 CC 1 chromosome 1 P46063,P43246 167 6.50e-03 871 2 2 1.000 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P46063,P43246 167 6.59e-03 877 2 2 1.000 0.002 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 P46063,P43246 167 7.06e-03 18 2 1 0.500 0.056 GO:0002312 BP 1 B cell activation involved in immune response 1 P43246 167 7.63e-03 670 2 2 1.000 0.003 GO:0006259 BP 1 DNA metabolic process 1 P46063,P43246 167 7.84e-03 50 2 1 0.500 0.020 TF:M04448_1 tf 1 Factor: VENTX; motif: ANCGATTAR; match class: 1 1 P46063 167 7.85e-03 20 2 1 0.500 0.050 GO:0002562 BP 1 somatic diversification of immune receptors via germline recombination within a single locus 1 P43246 167 7.85e-03 20 2 1 0.500 0.050 GO:0016445 BP 1 somatic diversification of immunoglobulins 1 P43246 167 7.85e-03 20 2 1 0.500 0.050 GO:0000217 MF 1 DNA secondary structure binding 1 P43246 167 7.85e-03 20 2 1 0.500 0.050 GO:0016444 BP 1 somatic cell DNA recombination 1 P43246 167 7.87e-03 958 2 2 1.000 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P46063,P43246 167 8.05e-03 969 2 2 1.000 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P46063,P43246 167 8.15e-03 52 2 1 0.500 0.019 TF:M06814_0 tf 1 Factor: ZBTB38; motif: NKKKGGATCACMSGAC; match class: 0 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:289 cor 1 PCNA-MSH2-MSH6 complex 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:377 cor 1 PCNA-MutS-alpha-DNA initial complex 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:286 cor 1 PCNA-MSH2-MSH6 complex 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:2226 cor 1 MutS-alpha-PK-zeta complex 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:291 cor 1 MSH2-MLH1-PMS2 DNA-repair initiation complex 1 P43246 167 8.36e-03 3 2 1 0.500 0.333 CORUM:368 cor 1 ERCC1-ERCC4-MSH2 complex 1 P43246 167 8.61e-03 1002 2 2 1.000 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P46063,P43246 167 8.94e-03 57 2 1 0.500 0.018 TF:M05702_0 tf 1 Factor: ZNF-20; motif: KGGTACAAATCA; match class: 0 1 P46063 167 9.03e-03 23 2 1 0.500 0.043 GO:0043531 MF 1 ADP binding 1 P43246 167 9.03e-03 23 2 1 0.500 0.043 GO:0016064 BP 1 immunoglobulin mediated immune response 1 P43246 167 9.12e-03 4 2 1 0.500 0.250 OMIM:276300 omi 1 MISMATCH REPAIR CANCER SYNDROME; MMRCS;;MISMATCH REPAIR DEFICIENCY;;MMR DEFICIENCY;;CHILDHOOD CANCER SYNDROME;;BRAIN TUMOR-POLYPOSIS SYNDROME 1; BTPS1;;BTP1 SYNDROME;;TURCOT SYNDROME;;CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME; CMMRDS 1 P43246 167 9.42e-03 24 2 1 0.500 0.042 GO:0046546 BP 1 development of primary male sexual characteristics 1 P43246 167 9.42e-03 24 2 1 0.500 0.042 GO:0019724 BP 1 B cell mediated immunity 1 P43246 167 9.42e-03 24 2 1 0.500 0.042 GO:0008584 BP 1 male gonad development 1 P43246 167 9.81e-03 25 2 1 0.500 0.040 GO:0002377 BP 1 immunoglobulin production 1 P43246 167 1.00e-02 1276 2 2 1.000 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 P46063,P43246 167 1.02e-02 65 2 1 0.500 0.015 TF:M03927_1 tf 1 Factor: ZBTB7A; motif: NGCGACCACCNN; match class: 1 1 P43246 167 1.02e-02 26 2 1 0.500 0.038 GO:2000241 BP 1 regulation of reproductive process 1 P43246 167 1.02e-02 26 2 1 0.500 0.038 GO:0002200 BP 1 somatic diversification of immune receptors 1 P43246 167 1.02e-02 26 2 1 0.500 0.038 GO:0046661 BP 1 male sex differentiation 1 P43246 167 1.02e-02 26 2 1 0.500 0.038 GO:0042771 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 P43246 167 1.02e-02 1091 2 2 1.000 0.002 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 P46063,P43246 167 1.04e-02 1100 2 2 1.000 0.002 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P46063,P43246 167 1.10e-02 28 2 1 0.500 0.036 GO:0004003 MF 1 ATP-dependent DNA helicase activity 1 P46063 167 1.10e-02 1135 2 2 1.000 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P46063,P43246 167 1.11e-02 4 2 1 0.500 0.250 CORUM:431 cor 1 MSH2-MSH6-PMS2-MLH1 complex 1 P43246 167 1.11e-02 4 2 1 0.500 0.250 CORUM:370 cor 1 MSH2-MSH6-PMS1-MLH1 complex 1 P43246 167 1.11e-02 4 2 1 0.500 0.250 CORUM:369 cor 1 MSH2-MSH6-PMS2-MLH1 complex 1 P43246 167 1.11e-02 4 2 1 0.500 0.250 CORUM:290 cor 1 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex 1 P43246 167 1.14e-02 29 2 1 0.500 0.034 GO:0006298 BP 1 mismatch repair 1 P43246 167 1.17e-02 14 2 1 0.500 0.071 REAC:5358565 rea 1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1 P43246 167 1.17e-02 14 2 1 0.500 0.071 REAC:5358606 rea 1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1 P43246 167 1.25e-02 15 2 1 0.500 0.067 REAC:5358508 rea 1 Mismatch Repair 1 P43246 167 1.29e-02 33 2 1 0.500 0.030 GO:0000018 BP 1 regulation of DNA recombination 1 P43246 167 1.33e-02 34 2 1 0.500 0.029 GO:0035825 BP 1 reciprocal DNA recombination 1 P43246 167 1.33e-02 34 2 1 0.500 0.029 GO:0007131 BP 1 reciprocal meiotic recombination 1 P43246 167 1.37e-02 6 2 1 0.500 0.167 OMIM:120435 omi 1 HNPCC 1 P43246 167 1.39e-02 1274 2 2 1.000 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P46063,P43246 167 1.39e-02 5 2 1 0.500 0.200 CORUM:2224 cor 1 MSH2/6-BLM-p53-RAD51 complex 1 P43246 167 1.39e-02 5 2 1 0.500 0.200 CORUM:376 cor 1 PCNA-MutS-alpha-MutL-alpha-DNA complex 1 P43246 167 1.45e-02 922 2 2 1.000 0.002 GO:0003677 MF 1 DNA binding 1 P46063,P43246 167 1.45e-02 37 2 1 0.500 0.027 GO:1990391 CC 1 DNA repair complex 1 P43246 167 1.45e-02 37 2 1 0.500 0.027 GO:0051784 BP 1 negative regulation of nuclear division 1 P43246 167 1.49e-02 1317 2 2 1.000 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 P46063,P43246 167 1.51e-02 1329 2 2 1.000 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 P46063,P43246 167 1.53e-02 1337 2 2 1.000 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P46063,P43246 167 1.63e-02 23 2 1 0.500 0.043 KEGG:03430 keg 1 Mismatch repair 1 P43246 167 1.65e-02 42 2 1 0.500 0.024 GO:0008406 BP 1 gonad development 1 P43246 167 1.67e-02 1396 2 2 1.000 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 P46063,P43246 167 1.69e-02 43 2 1 0.500 0.023 GO:0072332 BP 1 intrinsic apoptotic signaling pathway by p53 class mediator 1 P43246 167 1.69e-02 43 2 1 0.500 0.023 GO:0045137 BP 1 development of primary sexual characteristics 1 P43246 167 1.69e-02 43 2 1 0.500 0.023 GO:0032392 BP 1 DNA geometric change 1 P46063 167 1.70e-02 1408 2 2 1.000 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P46063,P43246 167 1.73e-02 1419 2 2 1.000 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P46063,P43246 167 1.76e-02 45 2 1 0.500 0.022 GO:0043524 BP 1 negative regulation of neuron apoptotic process 1 P43246 167 1.78e-02 114 2 1 0.500 0.009 TF:M06155_0 tf 1 Factor: ZNF135; motif: NGTKGTGWAATC; match class: 0 1 P43246 167 1.83e-02 1459 2 2 1.000 0.001 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P46063,P43246 167 1.84e-02 47 2 1 0.500 0.021 GO:0003678 MF 1 DNA helicase activity 1 P46063 167 1.88e-02 1480 2 2 1.000 0.001 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P46063,P43246 167 1.88e-02 48 2 1 0.500 0.021 GO:0006301 BP 1 postreplication repair 1 P43246 167 1.88e-02 48 2 1 0.500 0.021 GO:0030183 BP 1 B cell differentiation 1 P43246 167 1.91e-02 1492 2 2 1.000 0.001 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P46063,P43246 167 1.92e-02 49 2 1 0.500 0.020 GO:0003684 MF 1 damaged DNA binding 1 P43246 167 2.02e-02 1535 2 2 1.000 0.001 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P46063,P43246 167 2.08e-02 53 2 1 0.500 0.019 GO:0007127 BP 1 meiosis I 1 P43246 167 2.08e-02 133 2 1 0.500 0.008 TF:M06159_0 tf 1 Factor: ZNF83; motif: NTGGCAAARARM; match class: 0 1 P46063 167 2.12e-02 1574 2 2 1.000 0.001 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P46063,P43246 167 2.14e-02 137 2 1 0.500 0.007 TF:M06701_0 tf 1 Factor: ZNF319; motif: NGGTWAAACCGA; match class: 0 1 P43246 167 2.15e-02 1583 2 2 1.000 0.001 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P46063,P43246 167 2.17e-02 1589 2 2 1.000 0.001 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P46063,P43246 167 2.17e-02 139 2 1 0.500 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 P43246 167 2.19e-02 1882 2 2 1.000 0.001 TF:M01058_0 tf 1 Factor: Gfi1b; motif: TAAATCACTGCW; match class: 0 1 P46063,P43246 167 2.19e-02 140 2 1 0.500 0.007 TF:M06084_0 tf 1 Factor: ZNF208; motif: NSGGGAAGRGGT; match class: 0 1 P46063 167 2.20e-02 1600 2 2 1.000 0.001 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P46063,P43246 167 2.23e-02 8 2 1 0.500 0.125 CORUM:434 cor 1 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) 1 P43246 167 2.23e-02 57 2 1 0.500 0.018 GO:0002285 BP 1 lymphocyte activation involved in immune response 1 P43246 167 2.25e-02 1621 2 2 1.000 0.001 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P46063,P43246 167 2.26e-02 1622 2 2 1.000 0.001 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P46063,P43246 167 2.26e-02 1622 2 2 1.000 0.001 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P46063,P43246 167 2.26e-02 1623 2 2 1.000 0.001 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P46063,P43246 167 2.27e-02 58 2 1 0.500 0.017 GO:0002440 BP 1 production of molecular mediator of immune response 1 P43246 167 2.28e-02 146 2 1 0.500 0.007 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 P46063 167 2.28e-02 1924 2 2 1.000 0.001 TF:M04340_1 tf 1 Factor: HOXA10; motif: NGYMATAAAAN; match class: 1 1 P46063,P43246 167 2.35e-02 60 2 1 0.500 0.017 GO:0007548 BP 1 sex differentiation 1 P43246 167 2.36e-02 1659 2 2 1.000 0.001 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P46063,P43246 167 2.37e-02 1663 2 2 1.000 0.001 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 P46063,P43246 167 2.39e-02 61 2 1 0.500 0.016 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 P43246 167 2.39e-02 61 2 1 0.500 0.016 GO:1901215 BP 1 negative regulation of neuron death 1 P43246 167 2.48e-02 159 2 1 0.500 0.006 TF:M00940_1 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 1 P43246 167 2.49e-02 1704 2 2 1.000 0.001 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P46063,P43246 167 2.50e-02 1212 2 2 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 P46063,P43246 167 2.62e-02 67 2 1 0.500 0.015 GO:0043523 BP 1 regulation of neuron apoptotic process 1 P43246 167 2.67e-02 1765 2 2 1.000 0.001 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P46063,P43246 167 2.72e-02 1780 2 2 1.000 0.001 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 P46063,P43246 167 2.72e-02 1782 2 2 1.000 0.001 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P46063,P43246 167 2.74e-02 1787 2 2 1.000 0.001 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P46063,P43246 167 2.74e-02 70 2 1 0.500 0.014 GO:0003697 MF 1 single-stranded DNA binding 1 P43246 167 2.74e-02 1788 2 2 1.000 0.001 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P46063,P43246 167 2.77e-02 1797 2 2 1.000 0.001 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P46063,P43246 167 2.78e-02 71 2 1 0.500 0.014 GO:0008094 MF 1 DNA-dependent ATPase activity 1 P46063 167 2.78e-02 10 2 1 0.500 0.100 CORUM:438 cor 1 GCN5-TRRAP histone acetyltransferase complex 1 P43246 167 2.79e-02 1803 2 2 1.000 0.001 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P46063,P43246 167 2.82e-02 72 2 1 0.500 0.014 GO:0000724 BP 1 double-strand break repair via homologous recombination 1 P46063 167 2.82e-02 72 2 1 0.500 0.014 GO:0000725 BP 1 recombinational repair 1 P46063 167 2.82e-02 72 2 1 0.500 0.014 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 P43246 167 2.84e-02 1820 2 2 1.000 0.001 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P46063,P43246 167 2.87e-02 1830 2 2 1.000 0.001 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 P46063,P43246 167 2.90e-02 74 2 1 0.500 0.014 GO:0051402 BP 1 neuron apoptotic process 1 P43246 167 2.92e-02 2174 2 2 1.000 0.001 TF:M04303_0 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 0 1 P46063,P43246 167 2.93e-02 188 2 1 0.500 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 P46063 167 2.96e-02 1857 2 2 1.000 0.001 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P46063,P43246 167 2.98e-02 191 2 1 0.500 0.005 TF:M07217_0 tf 1 Factor: MAX; motif: RRGCACATGK; match class: 0 1 P46063 167 3.01e-02 77 2 1 0.500 0.013 GO:0002449 BP 1 lymphocyte mediated immunity 1 P43246 167 3.03e-02 1880 2 2 1.000 0.001 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P46063,P43246 167 3.04e-02 1883 2 2 1.000 0.001 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P46063,P43246 167 3.09e-02 79 2 1 0.500 0.013 GO:0010212 BP 1 response to ionizing radiation 1 P43246 167 3.11e-02 1904 2 2 1.000 0.001 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P46063,P43246 167 3.13e-02 1909 2 2 1.000 0.001 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P46063,P43246 167 3.13e-02 80 2 1 0.500 0.013 GO:0044773 BP 1 mitotic DNA damage checkpoint 1 P43246 167 3.13e-02 80 2 1 0.500 0.013 GO:0051053 BP 1 negative regulation of DNA metabolic process 1 P43246 167 3.17e-02 340 2 2 1.000 0.006 MI:mmu-miR-694 mi 1 MI:mmu-miR-694 1 P46063,P43246 167 3.20e-02 1932 2 2 1.000 0.001 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P46063,P43246 167 3.20e-02 1932 2 2 1.000 0.001 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P46063,P43246 167 3.21e-02 1933 2 2 1.000 0.001 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P46063,P43246 167 3.21e-02 82 2 1 0.500 0.012 GO:0048608 BP 1 reproductive structure development 1 P43246 167 3.21e-02 82 2 1 0.500 0.012 GO:0061458 BP 1 reproductive system development 1 P43246 167 3.21e-02 206 2 1 0.500 0.005 TF:M00736_1 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 1 P43246 167 3.26e-02 1950 2 2 1.000 0.001 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P46063,P43246 167 3.29e-02 84 2 1 0.500 0.012 GO:0002366 BP 1 leukocyte activation involved in immune response 1 P43246 167 3.33e-02 85 2 1 0.500 0.012 GO:0002263 BP 1 cell activation involved in immune response 1 P43246 167 3.34e-02 12 2 1 0.500 0.083 CORUM:433 cor 1 BASC complex (BRCA1-associated genome surveillance complex) 1 P43246 167 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P46063,P43246 167 3.35e-02 2331 2 2 1.000 0.001 TF:M02092_1 tf 1 Factor: Egr-2; motif: CCCMCNCN; match class: 1 1 P46063,P43246 167 3.37e-02 86 2 1 0.500 0.012 GO:0042113 BP 1 B cell activation 1 P43246 167 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 P46063,P43246 167 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P46063,P43246 167 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P46063,P43246 167 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P46063,P43246 167 3.40e-02 87 2 1 0.500 0.011 GO:0044774 BP 1 mitotic DNA integrity checkpoint 1 P43246 167 3.42e-02 1996 2 2 1.000 0.001 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P46063,P43246 167 3.42e-02 1998 2 2 1.000 0.001 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P46063,P43246 167 3.44e-02 88 2 1 0.500 0.011 GO:0070035 MF 1 purine NTP-dependent helicase activity 1 P46063 167 3.44e-02 88 2 1 0.500 0.011 GO:0008026 MF 1 ATP-dependent helicase activity 1 P46063 167 3.45e-02 2365 2 2 1.000 0.001 TF:M07424_0 tf 1 Factor: MEF-2; motif: NNYTATTTTTAGN; match class: 0 1 P46063,P43246 167 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 P46063,P43246 167 3.51e-02 2024 2 2 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P46063,P43246 167 3.52e-02 2026 2 2 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P46063,P43246 167 3.56e-02 91 2 1 0.500 0.011 GO:0043566 MF 1 structure-specific DNA binding 1 P43246 167 3.58e-02 2043 2 2 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P46063,P43246 167 3.60e-02 2049 2 2 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P46063,P43246 167 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 P46063,P43246 167 3.62e-02 2055 2 2 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P46063,P43246 167 3.64e-02 93 2 1 0.500 0.011 GO:0007126 BP 1 meiotic nuclear division 1 P43246 167 3.64e-02 93 2 1 0.500 0.011 GO:0009411 BP 1 response to UV 1 P43246 167 3.64e-02 2060 2 2 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P46063,P43246 167 3.66e-02 2436 2 2 1.000 0.001 TF:M01001_0 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 0 1 P46063,P43246 167 3.68e-02 2071 2 2 1.000 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 P46063,P43246 167 3.72e-02 95 2 1 0.500 0.011 GO:0002250 BP 1 adaptive immune response 1 P43246 167 3.73e-02 2086 2 2 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P46063,P43246 167 3.75e-02 2092 2 2 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P46063,P43246 167 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 P46063 167 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P46063,P43246 167 3.82e-02 2110 2 2 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P46063,P43246 167 3.83e-02 98 2 1 0.500 0.010 GO:0051321 BP 1 meiotic cell cycle 1 P43246 167 3.83e-02 98 2 1 0.500 0.010 GO:1903046 BP 1 meiotic cell cycle process 1 P43246 167 3.84e-02 247 2 1 0.500 0.004 TF:M01029_1 tf 1 Factor: TFE; motif: TCATGTGN; match class: 1 1 P46063 167 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P46063,P43246 167 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P46063,P43246 167 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 P46063,P43246 167 3.91e-02 100 2 1 0.500 0.010 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 P43246 167 3.92e-02 2139 2 2 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P46063,P43246 167 3.95e-02 101 2 1 0.500 0.010 GO:1901214 BP 1 regulation of neuron death 1 P43246 167 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P46063,P43246 167 4.02e-02 2165 2 2 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 P46063,P43246 167 4.03e-02 103 2 1 0.500 0.010 GO:0030098 BP 1 lymphocyte differentiation 1 P43246 167 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P46063,P43246 167 4.09e-02 58 2 1 0.500 0.017 KEGG:05210 keg 1 Colorectal cancer 1 P43246 167 4.11e-02 387 2 2 1.000 0.005 MI:hsa-miR-340 mi 1 MI:hsa-miR-340 1 P46063,P43246 167 4.11e-02 2188 2 2 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P46063,P43246 167 4.12e-02 2191 2 2 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P46063,P43246 167 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P46063,P43246 167 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P46063,P43246 167 4.18e-02 107 2 1 0.500 0.009 GO:0002443 BP 1 leukocyte mediated immunity 1 P43246 167 4.18e-02 107 2 1 0.500 0.009 GO:0051783 BP 1 regulation of nuclear division 1 P43246 167 4.19e-02 391 2 2 1.000 0.005 MI:hsa-miR-592 mi 1 MI:hsa-miR-592 1 P46063,P43246 167 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P46063,P43246 167 4.22e-02 108 2 1 0.500 0.009 GO:0008022 MF 1 protein C-terminus binding 1 P43246 167 4.24e-02 273 2 1 0.500 0.004 TF:M05501_0 tf 1 Factor: ZBTB8B; motif: NRGGGGATAGN; match class: 0 1 P46063 167 4.38e-02 112 2 1 0.500 0.009 GO:0000287 MF 1 magnesium ion binding 1 P43246 167 4.38e-02 112 2 1 0.500 0.009 GO:0004386 MF 1 helicase activity 1 P46063 167 4.38e-02 112 2 1 0.500 0.009 GO:0000781 CC 1 chromosome, telomeric region 1 P43246 167 4.39e-02 1607 2 2 1.000 0.001 GO:0016787 MF 1 hydrolase activity 1 P46063,P43246 167 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P46063,P43246 167 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P46063,P43246 167 4.44e-02 2274 2 2 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P46063,P43246 167 4.44e-02 2276 2 2 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.46e-02 114 2 1 0.500 0.009 GO:0070997 BP 1 neuron death 1 P43246 167 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 P43246 167 4.48e-02 2286 2 2 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.51e-02 290 2 1 0.500 0.003 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 P46063 167 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 P43246 167 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P46063,P43246 167 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P46063,P43246 167 4.64e-02 2743 2 2 1.000 0.001 TF:M04084_0 tf 1 Factor: POU3F4; motif: TGCATAAWTTA; match class: 0 1 P46063,P43246 167 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P46063,P43246 167 4.65e-02 412 2 2 1.000 0.005 MI:hsa-miR-208 mi 1 MI:hsa-miR-208 1 P46063,P43246 167 4.71e-02 2342 2 2 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P46063,P43246 167 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 P43246 167 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P46063,P43246 167 4.88e-02 125 2 1 0.500 0.008 GO:0000077 BP 1 DNA damage checkpoint 1 P43246 167 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 P46063,P43246 167 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P46063,P43246 167 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P46063,P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0006758 hp 1 Malignant genitourinary tract tumor 1 P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0100605 hp 1 Neoplasm of the larynx 1 P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0012118 hp 1 Laryngeal carcinoma 1 P43246 167 5.00e-02 128 2 1 0.500 0.008 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0030410 hp 1 Sebaceous gland carcinoma 1 P43246 167 5.00e-02 60 2 1 0.500 0.017 REAC:6796648 rea 1 TP53 Regulates Transcription of DNA Repair Genes 1 P43246 167 5.00e-02 71 2 1 0.500 0.014 KEGG:01524 keg 1 Platinum drug resistance 1 P43246 167 5.00e-02 22 2 1 0.500 0.045 OMIM:260350 omi 1 Pancreatic Cancer 1 P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0006778 hp 1 Benign genitourinary tract neoplasm 1 P43246 167 5.00e-02 18 2 1 0.500 0.056 CORUM:1335 cor 1 SNW1 complex 1 P43246 167 5.00e-02 3 2 1 0.500 0.333 HP:0006719 hp 1 Benign gastrointestinal tract tumors 1 P43246 168 2.27e-04 99 2 2 1.000 0.020 GO:0016810 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Q9Y2T3,Q96NU7 168 5.40e-04 1 2 1 0.500 1.000 GO:0008892 MF 1 guanine deaminase activity 1 Q9Y2T3 168 1.62e-03 3 2 1 0.500 0.333 GO:0046098 BP 1 guanine metabolic process 1 Q9Y2T3 168 1.65e-03 266 2 2 1.000 0.008 GO:1901565 BP 1 organonitrogen compound catabolic process 1 Q9Y2T3,Q96NU7 168 2.60e-03 334 2 2 1.000 0.006 GO:0046700 BP 1 heterocycle catabolic process 1 Q9Y2T3,Q96NU7 168 2.63e-03 336 2 2 1.000 0.006 GO:0044270 BP 1 cellular nitrogen compound catabolic process 1 Q9Y2T3,Q96NU7 168 2.70e-03 340 2 2 1.000 0.006 GO:0019439 BP 1 aromatic compound catabolic process 1 Q9Y2T3,Q96NU7 168 2.70e-03 5 2 1 0.500 0.200 GO:0006547 BP 1 histidine metabolic process 1 Q96NU7 168 2.70e-03 5 2 1 0.500 0.200 GO:0006548 BP 1 histidine catabolic process 1 Q96NU7 168 2.70e-03 5 2 1 0.500 0.200 GO:0016812 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1 Q96NU7 168 2.70e-03 5 2 1 0.500 0.200 GO:0052805 BP 1 imidazole-containing compound catabolic process 1 Q96NU7 168 2.97e-03 357 2 2 1.000 0.006 GO:1901361 BP 1 organic cyclic compound catabolic process 1 Q9Y2T3,Q96NU7 168 3.24e-03 6 2 1 0.500 0.167 GO:0052803 BP 1 imidazole-containing compound metabolic process 1 Q96NU7 168 3.39e-03 6 2 1 0.500 0.167 REAC:70921 rea 1 Histidine catabolism 1 Q96NU7 168 5.08e-03 9 2 1 0.500 0.111 REAC:74259 rea 1 Purine catabolism 1 Q9Y2T3 168 7.55e-03 14 2 1 0.500 0.071 GO:0006144 BP 1 purine nucleobase metabolic process 1 Q9Y2T3 168 7.64e-03 572 2 2 1.000 0.003 GO:0044712 BP 1 single-organism catabolic process 1 Q9Y2T3,Q96NU7 168 9.41e-03 60 2 1 0.500 0.017 TF:M07311_1 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 1 1 Q9Y2T3 168 9.87e-03 1265 2 2 1.000 0.002 TF:M00423_0 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 0 1 Q9Y2T3,Q96NU7 168 1.05e-02 1108 2 2 1.000 0.002 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 Q9Y2T3,Q96NU7 168 1.07e-02 68 2 1 0.500 0.015 TF:M06464_0 tf 1 Factor: znf679; motif: GGGCATGGCGKC; match class: 0 1 Q96NU7 168 1.14e-02 1359 2 2 1.000 0.001 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q9Y2T3,Q96NU7 168 1.29e-02 24 2 1 0.500 0.042 GO:0016814 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1 Q9Y2T3 168 1.29e-02 24 2 1 0.500 0.042 GO:0009112 BP 1 nucleobase metabolic process 1 Q9Y2T3 168 1.35e-02 25 2 1 0.500 0.040 GO:0019239 MF 1 deaminase activity 1 Q9Y2T3 168 1.43e-02 1524 2 2 1.000 0.001 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q9Y2T3,Q96NU7 168 1.53e-02 98 2 1 0.500 0.010 TF:M06739_0 tf 1 Factor: ZNF358; motif: NTRTGAAGAATM; match class: 0 1 Q9Y2T3 168 1.61e-02 1616 2 2 1.000 0.001 TF:M03833_1 tf 1 Factor: NKX3A; motif: NCACTTANTYN; match class: 1 1 Q9Y2T3,Q96NU7 168 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q96NU7 168 1.72e-02 32 2 1 0.500 0.031 GO:0006195 BP 1 purine nucleotide catabolic process 1 Q9Y2T3 168 1.78e-02 114 2 1 0.500 0.009 TF:M01774_1 tf 1 Factor: TBR2; motif: AGGTGTGAA; match class: 1 1 Q9Y2T3 168 1.80e-02 1709 2 2 1.000 0.001 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q9Y2T3,Q96NU7 168 1.80e-02 32 2 1 0.500 0.031 REAC:73847 rea 1 Purine metabolism 1 Q9Y2T3 168 2.04e-02 1818 2 2 1.000 0.001 TF:M04407_0 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 0 1 Q9Y2T3,Q96NU7 168 2.05e-02 38 2 1 0.500 0.026 GO:0072523 BP 1 purine-containing compound catabolic process 1 Q9Y2T3 168 2.09e-02 37 2 1 0.500 0.027 REAC:6788656 rea 1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 1 Q96NU7 168 2.19e-02 1883 2 2 1.000 0.001 TF:M04505_0 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 0 1 Q9Y2T3,Q96NU7 168 2.19e-02 1883 2 2 1.000 0.001 TF:M04623_0 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 0 1 Q9Y2T3,Q96NU7 168 2.28e-02 1924 2 2 1.000 0.001 TF:M04340_1 tf 1 Factor: HOXA10; motif: NGYMATAAAAN; match class: 1 1 Q9Y2T3,Q96NU7 168 2.37e-02 44 2 1 0.500 0.023 GO:0009166 BP 1 nucleotide catabolic process 1 Q9Y2T3 168 2.51e-02 161 2 1 0.500 0.006 TF:M05322_0 tf 1 Factor: T-box; motif: TTCACACCTR; match class: 0 1 Q9Y2T3 168 2.69e-02 50 2 1 0.500 0.020 GO:1901292 BP 1 nucleoside phosphate catabolic process 1 Q9Y2T3 168 3.02e-02 2213 2 2 1.000 0.001 TF:M00724_1 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 1 1 Q9Y2T3,Q96NU7 168 3.04e-02 2218 2 2 1.000 0.001 TF:M04077_1 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 1 1 Q9Y2T3,Q96NU7 168 3.04e-02 1141 2 2 1.000 0.002 GO:0044248 BP 1 cellular catabolic process 1 Q9Y2T3,Q96NU7 168 3.07e-02 197 2 1 0.500 0.005 TF:M05408_0 tf 1 Factor: ZNF438; motif: NAMGAKCGKATTGK; match class: 0 1 Q96NU7 168 3.47e-02 2370 2 2 1.000 0.001 TF:M04624_0 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 0 1 Q9Y2T3,Q96NU7 168 3.58e-02 230 2 1 0.500 0.004 TF:M07298_0 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 0 1 Q96NU7 168 3.77e-02 242 2 1 0.500 0.004 TF:M05961_1 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 1 1 Q9Y2T3 168 3.82e-02 2487 2 2 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q9Y2T3,Q96NU7 168 3.82e-02 2487 2 2 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q9Y2T3,Q96NU7 168 3.82e-02 2487 2 2 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q9Y2T3,Q96NU7 168 3.89e-02 1290 2 2 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 Q9Y2T3,Q96NU7 168 3.92e-02 2519 2 2 1.000 0.001 TF:M00744_1 tf 1 Factor: POU1F1; motif: ATGAATAAWT; match class: 1 1 Q9Y2T3,Q96NU7 168 3.94e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 Q9Y2T3,Q96NU7 168 3.97e-02 255 2 1 0.500 0.004 TF:M07337_0 tf 1 Factor: SMAR1; motif: YAAMSTGCTGAK; match class: 0 1 Q9Y2T3 168 4.04e-02 75 2 1 0.500 0.013 GO:1901606 BP 1 alpha-amino acid catabolic process 1 Q96NU7 168 4.09e-02 76 2 1 0.500 0.013 GO:0046434 BP 1 organophosphate catabolic process 1 Q9Y2T3 168 4.15e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 Q9Y2T3,Q96NU7 168 4.26e-02 2626 2 2 1.000 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q9Y2T3,Q96NU7 168 4.26e-02 2628 2 2 1.000 0.001 TF:M04393_1 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 1 1 Q9Y2T3,Q96NU7 168 4.30e-02 2641 2 2 1.000 0.001 TF:M00947_0 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 0 1 Q9Y2T3,Q96NU7 168 4.34e-02 1362 2 2 1.000 0.001 GO:0009056 BP 1 catabolic process 1 Q9Y2T3,Q96NU7 168 4.37e-02 281 2 1 0.500 0.004 TF:M05347_1 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 1 1 Q96NU7 168 4.52e-02 291 2 1 0.500 0.003 TF:M07258_1 tf 1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 1 1 Q96NU7 168 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q96NU7 168 4.83e-02 2797 2 2 1.000 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q9Y2T3,Q96NU7 168 4.86e-02 626 2 2 1.000 0.003 MI:mmu-miR-291b-3p mi 1 MI:mmu-miR-291b-3p 1 Q9Y2T3,Q96NU7 168 4.89e-02 628 2 2 1.000 0.003 MI:hsa-miR-519b-3p mi 1 MI:hsa-miR-519b-3p 1 Q9Y2T3,Q96NU7 168 4.97e-02 2837 2 2 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 Q9Y2T3,Q96NU7 168 4.97e-02 2837 2 2 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 Q9Y2T3,Q96NU7 168 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 Q9Y2T3 168 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q9Y2T3 168 5.00e-02 2846 2 2 1.000 0.001 TF:M04392_1 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 1 1 Q9Y2T3,Q96NU7 168 5.00e-02 18 2 1 0.500 0.056 KEGG:00340 keg 1 Histidine metabolism 1 Q96NU7 168 5.00e-02 93 2 1 0.500 0.011 GO:0009063 BP 1 cellular amino acid catabolic process 1 Q96NU7 168 5.00e-02 635 2 2 1.000 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 Q9Y2T3,Q96NU7 168 5.00e-02 89 2 1 0.500 0.011 REAC:15869 rea 1 Metabolism of nucleotides 1 Q9Y2T3 169 1.73e-03 1 2 1 0.500 1.000 GO:1903905 BP 1 positive regulation of establishment of T cell polarity 1 Q14254 169 3.45e-03 2 2 1 0.500 0.500 GO:1903903 BP 1 regulation of establishment of T cell polarity 1 Q14254 169 3.45e-03 2 2 1 0.500 0.500 GO:0001768 BP 1 establishment of T cell polarity 1 Q14254 169 5.18e-03 3 2 1 0.500 0.333 GO:0044860 BP 1 protein localization to plasma membrane raft 1 Q14254 169 5.18e-03 3 2 1 0.500 0.333 GO:0001767 BP 1 establishment of lymphocyte polarity 1 Q14254 169 8.63e-03 5 2 1 0.500 0.200 GO:1903044 BP 1 protein localization to membrane raft 1 Q14254 169 1.04e-02 6 2 1 0.500 0.167 GO:0031254 CC 1 cell trailing edge 1 Q14254 169 1.04e-02 6 2 1 0.500 0.167 GO:0001931 CC 1 uropod 1 Q14254 169 1.04e-02 6 2 1 0.500 0.167 GO:1902992 BP 1 negative regulation of amyloid precursor protein catabolic process 1 Q14254 169 1.14e-02 1152 2 2 1.000 0.002 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 Q14254,Q6UWV2 169 1.21e-02 7 2 1 0.500 0.143 GO:0034139 BP 1 regulation of toll-like receptor 3 signaling pathway 1 Q14254 169 1.21e-02 7 2 1 0.500 0.143 GO:0016600 CC 1 flotillin complex 1 Q14254 169 1.21e-02 7 2 1 0.500 0.143 GO:0001765 BP 1 membrane raft assembly 1 Q14254 169 1.63e-02 1380 2 2 1.000 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q14254,Q6UWV2 169 1.73e-02 10 2 1 0.500 0.100 GO:1902991 BP 1 regulation of amyloid precursor protein catabolic process 1 Q14254 169 1.90e-02 11 2 1 0.500 0.091 GO:0034138 BP 1 toll-like receptor 3 signaling pathway 1 Q14254 169 1.90e-02 11 2 1 0.500 0.091 GO:0031579 BP 1 membrane raft organization 1 Q14254 169 2.42e-02 14 2 1 0.500 0.071 GO:2000114 BP 1 regulation of establishment of cell polarity 1 Q14254 169 2.76e-02 16 2 1 0.500 0.062 GO:0045661 BP 1 regulation of myoblast differentiation 1 Q14254 169 2.76e-02 16 2 1 0.500 0.062 GO:0034114 BP 1 regulation of heterotypic cell-cell adhesion 1 Q14254 169 2.76e-02 16 2 1 0.500 0.062 GO:0032878 BP 1 regulation of establishment or maintenance of cell polarity 1 Q14254 169 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 Q14254,Q6UWV2 169 2.93e-02 17 2 1 0.500 0.059 GO:0042987 BP 1 amyloid precursor protein catabolic process 1 Q14254 169 2.96e-02 161 2 1 0.500 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q14254 169 3.28e-02 19 2 1 0.500 0.053 GO:0071709 BP 1 membrane assembly 1 Q14254 169 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 Q14254,Q6UWV2 169 3.45e-02 20 2 1 0.500 0.050 GO:0044091 BP 1 membrane biogenesis 1 Q14254 169 3.87e-02 809 2 2 1.000 0.002 TF:M02058_0 tf 1 Factor: SAP1A; motif: NCCGGAARYN; match class: 0 1 Q14254,Q6UWV2 169 3.87e-02 809 2 2 1.000 0.002 TF:M03990_0 tf 1 Factor: GABPA; motif: ACCGGAAGTN; match class: 0 1 Q14254,Q6UWV2 169 4.14e-02 24 2 1 0.500 0.042 GO:0042982 BP 1 amyloid precursor protein metabolic process 1 Q14254 169 5.00e-02 121 2 1 0.500 0.008 KEGG:04910 keg 1 Insulin signaling pathway 1 Q14254 169 5.00e-02 4 2 1 0.500 0.250 CORUM:522 cor 1 Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex 1 Q14254 169 5.00e-02 919 2 2 1.000 0.002 TF:M00991_0 tf 1 Factor: Cdx; motif: NAYNRHNARAKTHATAAA; match class: 0 1 Q14254,Q6UWV2 169 5.00e-02 29 2 1 0.500 0.034 GO:0045445 BP 1 myoblast differentiation 1 Q14254 170 1.34e-37 14 13 12 0.923 0.857 GO:0000176 CC 1 nuclear exosome (RNase complex) 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q9NPD3,Q13901,Q5RKV6 170 1.46e-37 23 13 13 1.000 0.565 GO:1905354 CC 1 exoribonuclease complex 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.46e-37 23 13 13 1.000 0.565 GO:0000178 CC 1 exosome (RNase complex) 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.26e-29 14 13 10 0.769 0.714 GO:0016075 BP 1 rRNA catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3,Q5RKV6 170 1.09e-27 32 13 11 0.846 0.344 GO:0004532 MF 1 exoribonuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.15e-26 21 13 10 0.769 0.476 GO:0034661 BP 1 ncRNA catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3,Q5RKV6 170 2.07e-26 12 13 9 0.692 0.750 GO:0071027 BP 1 nuclear RNA surveillance 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q01780,Q9NPD3,Q5RKV6 170 2.07e-26 12 13 9 0.692 0.750 GO:0071028 BP 1 nuclear mRNA surveillance 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q01780,Q9NPD3,Q5RKV6 170 6.72e-26 13 13 9 0.692 0.692 GO:0071025 BP 1 RNA surveillance 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q01780,Q9NPD3,Q5RKV6 170 2.17e-25 8 13 8 0.615 1.000 GO:0034427 BP 1 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 2.17e-25 8 13 8 0.615 1.000 GO:0034475 BP 1 U4 snRNA 3'-end processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 4.70e-25 15 13 9 0.692 0.600 GO:0000177 CC 1 cytoplasmic exosome (RNase complex) 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9NPD3,Q5RKV6 170 7.54e-24 65 13 11 0.846 0.169 GO:0004527 MF 1 exonuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 2.48e-23 11 13 10 0.769 0.909 CORUM:789 cor 1 Exosome 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 3.57e-23 11 13 8 0.615 0.727 GO:0034472 BP 1 snRNA 3'-end processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 4.82e-23 76 13 11 0.846 0.145 GO:0004540 MF 1 ribonuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 6.92e-23 229 13 13 1.000 0.057 GO:0006364 BP 1 rRNA processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 8.23e-23 232 13 13 1.000 0.056 GO:0016072 BP 1 rRNA metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.79e-22 13 13 8 0.615 0.615 GO:0031125 BP 1 rRNA 3'-end processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 9.16e-22 278 13 13 1.000 0.047 GO:0042254 BP 1 ribosome biogenesis 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 9.36e-22 29 13 9 0.692 0.310 GO:0043928 BP 1 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.34e-21 30 13 9 0.692 0.300 GO:0000460 BP 1 maturation of 5.8S rRNA 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q01780,Q9NPD3,Q13901 170 1.88e-21 31 13 9 0.692 0.290 GO:0000291 BP 1 nuclear-transcribed mRNA catabolic process, exonucleolytic 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.29e-20 10 13 9 0.692 0.900 CORUM:788 cor 1 Exosome 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.80e-20 348 13 13 1.000 0.037 GO:0034470 BP 1 ncRNA processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.39e-20 21 13 8 0.615 0.381 GO:0043628 BP 1 ncRNA 3'-end processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 6.90e-20 22 13 8 0.615 0.364 GO:0016180 BP 1 snRNA processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 9.28e-20 394 13 13 1.000 0.033 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 9.76e-20 16 13 9 0.692 0.562 REAC:429958 rea 1 mRNA decay by 3' to 5' exoribonuclease 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 9.76e-20 16 13 9 0.692 0.562 REAC:450513 rea 1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.33e-19 151 13 11 0.846 0.073 GO:0004518 MF 1 nuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 2.07e-19 17 13 9 0.692 0.529 REAC:450385 rea 1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 2.07e-19 17 13 9 0.692 0.529 REAC:450604 rea 1 KSRP (KHSRP) binds and destabilizes mRNA 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 3.36e-19 26 13 8 0.615 0.308 GO:0000175 MF 1 3'-5'-exoribonuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3 170 4.78e-19 27 13 8 0.615 0.296 GO:0016896 MF 1 exoribonuclease activity, producing 5'-phosphomonoesters 1 Q15024,Q9NQT4,Q9NQT5,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3 170 6.86e-19 6 13 6 0.462 1.000 GO:0071035 BP 1 nuclear polyadenylation-dependent rRNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 6.86e-19 6 13 6 0.462 1.000 GO:0071046 BP 1 nuclear polyadenylation-dependent ncRNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 6.86e-19 6 13 6 0.462 1.000 GO:0043634 BP 1 polyadenylation-dependent ncRNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 6.86e-19 6 13 6 0.462 1.000 GO:0071029 BP 1 nuclear ncRNA surveillance 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 1.61e-18 61 13 9 0.692 0.148 GO:0000288 BP 1 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.73e-18 492 13 13 1.000 0.026 GO:0034660 BP 1 ncRNA metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.50e-18 21 13 9 0.692 0.429 REAC:380994 rea 1 ATF4 activates genes 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 3.02e-18 199 13 11 0.846 0.055 GO:0006402 BP 1 mRNA catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 4.80e-18 7 13 6 0.462 0.857 GO:0043633 BP 1 polyadenylation-dependent RNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 8.00e-18 217 13 11 0.846 0.051 GO:0006401 BP 1 RNA catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.11e-17 24 13 9 0.692 0.375 REAC:381042 rea 1 PERK regulates gene expression 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 2.05e-17 41 13 8 0.615 0.195 GO:0016796 MF 1 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1 Q15024,Q9NQT4,Q9NQT5,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3 170 3.79e-17 44 13 8 0.615 0.182 GO:0008408 MF 1 3'-5' exonuclease activity 1 Q15024,Q9NQT4,Q9NQT5,Q06265,Q13868,Q8TF46,Q01780,Q9NPD3 170 3.47e-16 304 13 11 0.846 0.036 GO:0034655 BP 1 nucleobase-containing compound catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 3.73e-16 188 13 10 0.769 0.053 GO:0000956 BP 1 nuclear-transcribed mRNA catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 4.55e-16 752 13 13 1.000 0.017 GO:0006396 BP 1 RNA processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 9.87e-16 334 13 11 0.846 0.033 GO:0046700 BP 1 heterocycle catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 9.89e-16 5 13 5 0.385 1.000 GO:0071038 BP 1 nuclear polyadenylation-dependent tRNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 9.89e-16 5 13 5 0.385 1.000 GO:0071051 BP 1 polyadenylation-dependent snoRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q13868,Q9NPD3,Q5RKV6 170 1.06e-15 336 13 11 0.846 0.033 GO:0044270 BP 1 cellular nitrogen compound catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.19e-15 123 13 9 0.692 0.073 GO:0043488 BP 1 regulation of mRNA stability 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.20e-15 340 13 11 0.846 0.032 GO:0019439 BP 1 aromatic compound catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.73e-15 128 13 9 0.692 0.070 GO:0043487 BP 1 regulation of RNA stability 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 2.07e-15 357 13 11 0.846 0.031 GO:1901361 BP 1 organic cyclic compound catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 3.26e-15 200 13 12 0.923 0.060 REAC:72312 rea 1 rRNA processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.93e-15 6 13 5 0.385 0.833 GO:0016078 BP 1 tRNA catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 9.18e-15 84 13 8 0.615 0.095 GO:0016073 BP 1 snRNA metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 2.07e-14 7 13 5 0.385 0.714 GO:0031126 BP 1 snoRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q13868,Q9NPD3,Q5RKV6 170 2.91e-14 1033 13 13 1.000 0.013 GO:1902494 CC 1 catalytic complex 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.45e-14 54 13 9 0.692 0.167 REAC:429914 rea 1 Deadenylation-dependent mRNA decay 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 5.53e-14 8 13 5 0.385 0.625 GO:0000467 BP 1 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 5.53e-14 8 13 5 0.385 0.625 GO:0000459 BP 1 exonucleolytic trimming involved in rRNA processing 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 7.92e-14 109 13 8 0.615 0.073 GO:0031123 BP 1 RNA 3'-end processing 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9NPD3,Q5RKV6 170 9.39e-14 504 13 11 0.846 0.022 GO:0016788 MF 1 hydrolase activity, acting on ester bonds 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.24e-13 9 13 5 0.385 0.556 GO:0043144 BP 1 snoRNA processing 1 Q9NQT4,Q9NQT5,Q13868,Q9NPD3,Q5RKV6 170 1.24e-13 9 13 5 0.385 0.556 GO:0090503 BP 1 RNA phosphodiester bond hydrolysis, exonucleolytic 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 1.38e-13 522 13 11 0.846 0.021 GO:0016071 BP 1 mRNA metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 2.49e-13 10 13 5 0.385 0.500 GO:0016074 BP 1 snoRNA metabolic process 1 Q9NQT4,Q9NQT5,Q13868,Q9NPD3,Q5RKV6 170 1.51e-12 78 13 9 0.692 0.115 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 2.71e-12 83 13 9 0.692 0.108 REAC:450531 rea 1 Regulation of mRNA stability by proteins that bind AU-rich elements 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 5.26e-12 727 13 11 0.846 0.015 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 6.97e-12 318 13 9 0.692 0.028 GO:0010608 BP 1 posttranscriptional regulation of gene expression 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 8.41e-12 18 13 5 0.385 0.278 GO:0000466 BP 1 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 1.90e-11 6 13 4 0.308 0.667 GO:0045006 BP 1 DNA deamination 1 Q9NQT4,Q9NQT5,Q9NPD3,Q5RKV6 170 1.99e-11 21 13 5 0.385 0.238 GO:0000469 BP 1 cleavage involved in rRNA processing 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 4.04e-11 876 13 11 0.846 0.013 GO:0009057 BP 1 macromolecule catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.03e-10 1932 13 13 1.000 0.007 GO:0044085 BP 1 cellular component biogenesis 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 7.17e-10 1141 13 11 0.846 0.010 GO:0044248 BP 1 cellular catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.46e-09 3 13 3 0.231 1.000 GO:0034476 BP 1 U5 snRNA 3'-end processing 1 Q15024,Q96B26,Q06265 170 1.46e-09 3 13 3 0.231 1.000 GO:0034473 BP 1 U1 snRNA 3'-end processing 1 Q15024,Q96B26,Q06265 170 1.65e-09 48 13 5 0.385 0.104 GO:0090501 BP 1 RNA phosphodiester bond hydrolysis 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 2.29e-09 16 13 4 0.308 0.250 GO:0035327 CC 1 transcriptionally active chromatin 1 Q9NQT4,Q9NQT5,Q01780,Q9NPD3 170 2.71e-09 1290 13 11 0.846 0.009 GO:1901575 BP 1 organic substance catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 3.86e-09 645 13 9 0.692 0.014 GO:0005730 CC 1 nucleolus 1 Q9NQT4,Q9NQT5,Q06265,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.87e-09 19 13 4 0.308 0.211 GO:0017091 MF 1 AU-rich element binding 1 Q15024,Q96B26,Q06265,Q9NPD3 170 4.87e-09 1362 13 11 0.846 0.008 GO:0009056 BP 1 catabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 5.66e-09 2627 13 13 1.000 0.005 GO:0016070 BP 1 RNA metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.84e-09 4 13 3 0.231 0.750 GO:0071034 BP 1 CUT catabolic process 1 Q9NQT5,Q13868,Q01780 170 5.84e-09 4 13 3 0.231 0.750 GO:0071047 BP 1 polyadenylation-dependent mRNA catabolic process 1 Q15024,Q96B26,Q06265 170 5.84e-09 4 13 3 0.231 0.750 GO:0071042 BP 1 nuclear polyadenylation-dependent mRNA catabolic process 1 Q15024,Q96B26,Q06265 170 5.84e-09 4 13 3 0.231 0.750 GO:0071033 BP 1 nuclear retention of pre-mRNA at the site of transcription 1 Q9NQT5,Q13868,Q01780 170 5.84e-09 4 13 3 0.231 0.750 GO:0071043 BP 1 CUT metabolic process 1 Q9NQT5,Q13868,Q01780 170 2.36e-08 2931 13 13 1.000 0.004 GO:0031981 CC 1 nuclear lumen 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.89e-08 1607 13 11 0.846 0.007 GO:0016787 MF 1 hydrolase activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 3.38e-08 3013 13 13 1.000 0.004 GO:0090304 BP 1 nucleic acid metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.10e-08 3058 13 13 1.000 0.004 GO:0010467 BP 1 gene expression 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 6.49e-08 3168 13 13 1.000 0.004 GO:0044428 CC 1 nuclear part 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.13e-07 1336 13 10 0.769 0.007 GO:0003723 MF 1 RNA binding 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.49e-07 116 13 5 0.385 0.043 GO:0090305 BP 1 nucleic acid phosphodiester bond hydrolysis 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 1.64e-07 2529 13 12 0.923 0.005 GO:0005654 CC 1 nucleoplasm 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.73e-07 3415 13 13 1.000 0.004 GO:0032991 CC 1 macromolecular complex 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.75e-07 10 13 3 0.231 0.300 GO:0008298 BP 1 intracellular mRNA localization 1 Q9NQT5,Q13868,Q01780 170 1.92e-07 3443 13 13 1.000 0.004 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.90e-07 3554 13 13 1.000 0.004 GO:0046483 BP 1 heterocycle metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.98e-07 3561 13 13 1.000 0.004 GO:0031974 CC 1 membrane-enclosed lumen 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.98e-07 3561 13 13 1.000 0.004 GO:0070013 CC 1 intracellular organelle lumen 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.98e-07 3561 13 13 1.000 0.004 GO:0043233 CC 1 organelle lumen 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.98e-07 3561 13 13 1.000 0.004 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.58e-07 3681 13 13 1.000 0.004 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.20e-07 149 13 5 0.385 0.034 GO:0006399 BP 1 tRNA metabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868 170 6.82e-07 62 13 4 0.308 0.065 GO:0006304 BP 1 DNA modification 1 Q9NQT4,Q9NQT5,Q9NPD3,Q5RKV6 170 1.14e-06 3948 13 13 1.000 0.003 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.41e-06 4013 13 13 1.000 0.003 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.53e-06 2 13 2 0.154 1.000 GO:0071031 BP 1 nuclear mRNA surveillance of mRNA 3'-end processing 1 Q9NQT5,Q13868 170 1.53e-06 2 13 2 0.154 1.000 GO:0071049 BP 1 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription 1 Q9NQT5,Q13868 170 3.11e-06 4264 13 13 1.000 0.003 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.84e-06 416 13 6 0.462 0.014 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q01780 170 4.46e-06 1960 13 10 0.769 0.005 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9NQT4,Q9NQT5,Q06265,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.46e-06 1960 13 10 0.769 0.005 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9NQT4,Q9NQT5,Q06265,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.11e-06 4430 13 13 1.000 0.003 GO:0005634 CC 1 nucleus 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.01e-05 2136 13 10 0.769 0.005 GO:0003676 MF 1 nucleic acid binding 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.41e-05 4990 13 13 1.000 0.003 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.82e-05 1924 13 9 0.692 0.005 GO:0065008 BP 1 regulation of biological quality 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 5.53e-05 5319 13 13 1.000 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 6.57e-05 2612 13 10 0.769 0.004 GO:1901363 MF 1 heterocyclic compound binding 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 7.78e-05 2660 13 10 0.769 0.004 GO:0097159 MF 1 organic cyclic compound binding 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.02e-04 1485 13 12 0.923 0.008 REAC:74160 rea 1 Gene Expression 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.06e-04 78 13 3 0.231 0.038 GO:0030307 BP 1 positive regulation of cell growth 1 Q06265,Q13868,Q9NPD3 170 1.19e-04 13 13 2 0.154 0.154 GO:0002208 BP 1 somatic diversification of immunoglobulins involved in immune response 1 Q9NQT5,Q5RKV6 170 1.19e-04 13 13 2 0.154 0.154 GO:0002204 BP 1 somatic recombination of immunoglobulin genes involved in immune response 1 Q9NQT5,Q5RKV6 170 1.19e-04 13 13 2 0.154 0.154 GO:0045190 BP 1 isotype switching 1 Q9NQT5,Q5RKV6 170 1.32e-04 2173 13 9 0.692 0.004 GO:0010468 BP 1 regulation of gene expression 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 1.38e-04 14 13 2 0.154 0.143 GO:0071044 BP 1 histone mRNA catabolic process 1 Q01780,Q9NPD3 170 1.38e-04 14 13 2 0.154 0.143 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 Q9NQT5,Q5RKV6 170 1.38e-04 14 13 2 0.154 0.143 GO:0016447 BP 1 somatic recombination of immunoglobulin gene segments 1 Q9NQT5,Q5RKV6 170 1.47e-04 10 13 3 0.231 0.300 CORUM:822 cor 1 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) 1 Q13868,Q01780,Q9NPD3 170 1.66e-04 5787 13 13 1.000 0.002 GO:0044446 CC 1 intracellular organelle part 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.02e-04 5877 13 13 1.000 0.002 GO:0044422 CC 1 organelle part 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.28e-04 101 13 3 0.231 0.030 GO:0045927 BP 1 positive regulation of growth 1 Q06265,Q13868,Q9NPD3 170 2.32e-04 18 13 2 0.154 0.111 GO:0002312 BP 1 B cell activation involved in immune response 1 Q9NQT5,Q5RKV6 170 2.88e-04 20 13 2 0.154 0.100 GO:0016444 BP 1 somatic cell DNA recombination 1 Q9NQT5,Q5RKV6 170 2.88e-04 20 13 2 0.154 0.100 GO:0002562 BP 1 somatic diversification of immune receptors via germline recombination within a single locus 1 Q9NQT5,Q5RKV6 170 2.88e-04 20 13 2 0.154 0.100 GO:0016445 BP 1 somatic diversification of immunoglobulins 1 Q9NQT5,Q5RKV6 170 3.22e-04 294 13 4 0.308 0.014 GO:0000785 CC 1 chromatin 1 Q9NQT4,Q9NQT5,Q01780,Q9NPD3 170 3.49e-04 6128 13 13 1.000 0.002 GO:0044238 BP 1 primary metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.83e-04 23 13 2 0.154 0.087 GO:0016064 BP 1 immunoglobulin mediated immune response 1 Q9NQT5,Q5RKV6 170 4.17e-04 24 13 2 0.154 0.083 GO:0019724 BP 1 B cell mediated immunity 1 Q9NQT5,Q5RKV6 170 4.30e-04 317 13 4 0.308 0.013 GO:0002252 BP 1 immune effector process 1 Q9NQT4,Q9NQT5,Q9NPD3,Q5RKV6 170 4.31e-04 4019 13 11 0.846 0.003 GO:0003824 MF 1 catalytic activity 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 4.53e-04 25 13 2 0.154 0.080 GO:0002377 BP 1 immunoglobulin production 1 Q9NQT5,Q5RKV6 170 4.76e-04 609 13 5 0.385 0.008 GO:0005694 CC 1 chromosome 1 Q9NQT4,Q9NQT5,Q06265,Q01780,Q9NPD3 170 4.90e-04 26 13 2 0.154 0.077 GO:0002200 BP 1 somatic diversification of immune receptors 1 Q9NQT5,Q5RKV6 170 4.99e-04 6299 13 13 1.000 0.002 GO:0044237 BP 1 cellular metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.70e-04 28 13 2 0.154 0.071 GO:0008334 BP 1 histone mRNA metabolic process 1 Q01780,Q9NPD3 170 7.27e-04 6484 13 13 1.000 0.002 GO:0071704 BP 1 organic substance metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 7.78e-04 2707 13 9 0.692 0.003 GO:0005829 CC 1 cytosol 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 8.52e-04 158 13 3 0.231 0.019 GO:0006403 BP 1 RNA localization 1 Q9NQT5,Q13868,Q01780 170 9.95e-04 6642 13 13 1.000 0.002 GO:0008152 BP 1 metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.05e-03 6671 13 13 1.000 0.002 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.69e-03 242 13 3 0.231 0.012 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q15024,Q99547,Q01780 170 2.06e-03 3063 13 9 0.692 0.003 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 2.28e-03 222 13 3 0.231 0.014 GO:0001558 BP 1 regulation of cell growth 1 Q06265,Q13868,Q9NPD3 170 2.36e-03 57 13 2 0.154 0.035 GO:0002285 BP 1 lymphocyte activation involved in immune response 1 Q9NQT5,Q5RKV6 170 2.44e-03 58 13 2 0.154 0.034 GO:0002440 BP 1 production of molecular mediator of immune response 1 Q9NQT5,Q5RKV6 170 2.94e-03 2 13 1 0.077 0.500 GO:0071048 BP 1 nuclear retention of unspliced pre-mRNA at the site of transcription 1 Q01780 170 2.94e-03 2 13 1 0.077 0.500 GO:0071030 BP 1 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing 1 Q01780 170 3.32e-03 2242 13 7 0.538 0.003 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q9NQT4,Q13868,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.35e-03 3263 13 9 0.692 0.003 GO:0019222 BP 1 regulation of metabolic process 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 3.73e-03 565 13 4 0.308 0.007 GO:0044427 CC 1 chromosomal part 1 Q9NQT4,Q9NQT5,Q01780,Q9NPD3 170 3.75e-03 72 13 2 0.154 0.028 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q9NQT5,Q5RKV6 170 4.27e-03 77 13 2 0.154 0.026 GO:0002449 BP 1 lymphocyte mediated immunity 1 Q9NQT5,Q5RKV6 170 4.41e-03 280 13 3 0.231 0.011 GO:0016049 BP 1 cell growth 1 Q06265,Q13868,Q9NPD3 170 4.50e-03 282 13 3 0.231 0.011 GO:0040008 BP 1 regulation of growth 1 Q06265,Q13868,Q9NPD3 170 4.78e-03 1746 13 6 0.462 0.003 TF:M00006_0 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 0 1 Q15024,Q9NQT5,Q06265,Q99547,Q8TF46,Q13901 170 4.98e-03 7517 13 13 1.000 0.002 GO:0043229 CC 1 intracellular organelle 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.05e-03 1765 13 6 0.462 0.003 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q15024,Q96B26,Q06265,Q8TF46,Q13901,Q5RKV6 170 5.07e-03 84 13 2 0.154 0.024 GO:0002366 BP 1 leukocyte activation involved in immune response 1 Q9NQT5,Q5RKV6 170 5.19e-03 85 13 2 0.154 0.024 GO:0002263 BP 1 cell activation involved in immune response 1 Q9NQT5,Q5RKV6 170 5.28e-03 3152 13 8 0.615 0.003 TF:M04379_1 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 1 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q9NPD3 170 5.31e-03 86 13 2 0.154 0.023 GO:0042113 BP 1 B cell activation 1 Q9NQT5,Q5RKV6 170 5.88e-03 4 13 1 0.077 0.250 GO:0008312 MF 1 7S RNA binding 1 Q13868 170 6.29e-03 6336 13 12 0.923 0.002 GO:0005515 MF 1 protein binding 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 6.45e-03 95 13 2 0.154 0.021 GO:0002250 BP 1 adaptive immune response 1 Q9NQT5,Q5RKV6 170 6.60e-03 7682 13 13 1.000 0.002 GO:0005488 MF 1 binding 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 6.91e-03 670 13 4 0.308 0.006 GO:0006259 BP 1 DNA metabolic process 1 Q9NQT4,Q9NQT5,Q9NPD3,Q5RKV6 170 7.13e-03 100 13 2 0.154 0.020 GO:0051607 BP 1 defense response to virus 1 Q9NQT4,Q9NPD3 170 7.36e-03 408 13 3 0.231 0.007 TF:M02002_0 tf 1 Factor: Evi-1; motif: TATCTTGTC; match class: 0 1 Q9NQT5,Q99547,Q01780 170 7.40e-03 4293 13 10 0.769 0.002 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 8.13e-03 107 13 2 0.154 0.019 GO:0002443 BP 1 leukocyte mediated immunity 1 Q9NQT5,Q5RKV6 170 8.76e-03 1165 13 5 0.385 0.004 GO:0002376 BP 1 immune system process 1 Q9NQT4,Q9NQT5,Q06265,Q9NPD3,Q5RKV6 170 9.49e-03 368 13 3 0.231 0.008 GO:0040007 BP 1 growth 1 Q06265,Q13868,Q9NPD3 170 9.60e-03 7906 13 13 1.000 0.002 GO:0043227 CC 1 membrane-bounded organelle 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.03e-02 153 13 2 0.154 0.013 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 Q99547,Q9NPD3 170 1.11e-02 5392 13 11 0.846 0.002 HPA:036010_02 hpa 1 skin 2; epidermal cells[Uncertain,Medium] 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 1.12e-02 11 13 1 0.077 0.091 TF:M00080_1 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 1 1 Q01780 170 1.13e-02 5 13 2 0.154 0.400 HP:0200147 hp 1 Neuronal loss in basal ganglia 1 Q9NQT5,Q96B26 170 1.13e-02 5 13 2 0.154 0.400 HP:0006850 hp 1 Hypoplasia of the ventral pons 1 Q9NQT5,Q96B26 170 1.16e-02 481 13 3 0.231 0.006 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 Q99547,Q9NPD3,Q13901 170 1.20e-02 2101 13 6 0.462 0.003 TF:M03793_0 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 0 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q13868,Q9NPD3 170 1.22e-02 12 13 1 0.077 0.083 TF:M05937_0 tf 1 Factor: ZNF582; motif: NKGGTATGAAGM; match class: 0 1 Q01780 170 1.32e-02 13 13 1 0.077 0.077 TF:M06328_0 tf 1 Factor: ZNF343; motif: KGTTGCTAAAGA; match class: 0 1 Q06265 170 1.35e-02 510 13 3 0.231 0.006 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 Q9NQT5,Q8TF46,Q9Y3B2 170 1.38e-02 5462 13 10 0.769 0.002 TF:M00240_1 tf 1 Factor: Nkx2-5; motif: TYAAGTG; match class: 1 1 Q9NQT4,Q9NQT5,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 1.49e-02 186 13 2 0.154 0.011 TF:M00457_0 tf 1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 0 1 Q99547,Q8TF46 170 1.52e-02 15 13 1 0.077 0.067 TF:M06246_1 tf 1 Factor: ZNF177; motif: NRWTGAAGAGCA; match class: 1 1 Q9Y3B2 170 1.62e-02 153 13 2 0.154 0.013 GO:0009615 BP 1 response to virus 1 Q9NQT4,Q9NPD3 170 1.67e-02 418 13 4 0.308 0.010 MI:hsa-miR-568 mi 1 MI:hsa-miR-568 1 Q96B26,Q99547,Q01780,Q13901 170 1.67e-02 5636 13 11 0.846 0.002 HPA:014010_02 hpa 1 esophagus; squamous epithelial cells[Uncertain,Medium] 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 1.76e-02 203 13 2 0.154 0.010 TF:M01233_1 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 1 1 Q8TF46,Q01780 170 1.76e-02 160 13 2 0.154 0.013 GO:0006310 BP 1 DNA recombination 1 Q9NQT5,Q5RKV6 170 1.84e-02 6993 13 12 0.923 0.002 GO:0005737 CC 1 cytoplasm 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 1.93e-02 168 13 2 0.154 0.012 GO:0098542 BP 1 defense response to other organism 1 Q9NQT4,Q9NPD3 170 2.01e-02 2337 13 6 0.462 0.003 TF:M04414_0 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 0 1 Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9NPD3 170 2.02e-02 20 13 1 0.077 0.050 TF:M03951_1 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 1 1 Q96B26 170 2.02e-02 20 13 1 0.077 0.050 TF:M05783_0 tf 1 Factor: ZNF667; motif: KGGGSCATTATC; match class: 0 1 Q8TF46 170 2.06e-02 8385 13 13 1.000 0.002 GO:0043226 CC 1 organelle 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.13e-02 2365 13 6 0.462 0.003 TF:M07424_0 tf 1 Factor: MEF-2; motif: NNYTATTTTTAGN; match class: 0 1 Q15024,Q06265,Q8TF46,Q9NPD3,Q13901,Q5RKV6 170 2.14e-02 447 13 4 0.308 0.009 MI:hsa-miR-587 mi 1 MI:hsa-miR-587 1 Q15024,Q9NQT4,Q8TF46,Q9Y3B2 170 2.26e-02 1124 13 4 0.308 0.004 TF:M04078_1 tf 1 Factor: POU3F2; motif: NWTGCATAAWTTA; match class: 1 1 Q15024,Q13868,Q99547,Q8TF46 170 2.37e-02 238 13 2 0.154 0.008 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 Q15024,Q01780 170 2.42e-02 24 13 1 0.077 0.042 TF:M04515_1 tf 1 Factor: E2F1; motif: WWTGGCGCCAAA; match class: 1 1 Q13868 170 2.42e-02 24 13 1 0.077 0.042 TF:M06632_1 tf 1 Factor: ZNF717; motif: GGGAAAAAGA; match class: 1 1 Q9NQT4 170 2.57e-02 1508 13 5 0.385 0.003 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 Q9NQT5,Q13868,Q99547,Q9Y3B2,Q01780 170 2.62e-02 26 13 1 0.077 0.038 TF:M04048_1 tf 1 Factor: MYBL2; motif: NNAACCGTTAN; match class: 1 1 Q15024 170 2.72e-02 27 13 1 0.077 0.037 TF:M01146_1 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 1 1 Q8TF46 170 2.74e-02 1191 13 4 0.308 0.003 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q9NQT4,Q9Y3B2,Q01780,Q5RKV6 170 2.75e-02 3258 13 7 0.538 0.002 TF:M03568_0 tf 1 Factor: TR4; motif: STGACCTTT; match class: 0 1 Q15024,Q9NQT5,Q96B26,Q06265,Q01780,Q13901,Q5RKV6 170 2.79e-02 1197 13 4 0.308 0.003 TF:M07319_1 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 1 1 Q06265,Q8TF46,Q01780,Q9NPD3 170 2.80e-02 260 13 2 0.154 0.008 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 Q15024,Q01780 170 2.81e-02 4237 13 9 0.692 0.002 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q15024,Q9NQT5,Q96B26,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q13901 170 2.82e-02 28 13 1 0.077 0.036 TF:M06782_0 tf 1 Factor: ZNF225; motif: NYCATAATAACC; match class: 0 1 Q13868 170 2.86e-02 3282 13 7 0.538 0.002 TF:M07326_0 tf 1 Factor: Mef-2A; motif: YTATWTTTARNNC; match class: 0 1 Q96B26,Q99547,Q8TF46,Q01780,Q9NPD3,Q13901,Q5RKV6 170 2.92e-02 9699 13 13 1.000 0.001 TF:M04692_1 tf 1 Factor: c-ets-1; motif: AACTACAACTCCC; match class: 1 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.05e-02 1856 13 5 0.385 0.003 TF:M02021_0 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 0 1 Q15024,Q9NQT4,Q13868,Q9NPD3,Q13901 170 3.10e-02 7114 13 11 0.846 0.002 TF:M07056_1 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 1 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 3.10e-02 7114 13 11 0.846 0.002 TF:M02114_1 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 1 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 3.12e-02 31 13 1 0.077 0.032 TF:M06248_0 tf 1 Factor: ZNF91; motif: NKGTGARAAAGM; match class: 0 1 Q9NQT5 170 3.15e-02 7127 13 11 0.846 0.002 TF:M00199_1 tf 1 Factor: AP-1; motif: NTGASTCAG; match class: 1 1 Q15024,Q9NQT5,Q96B26,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.18e-02 7134 13 11 0.846 0.002 TF:M01216_0 tf 1 Factor: FOXO1; motif: NWAAACAAN; match class: 0 1 Q15024,Q9NQT5,Q96B26,Q06265,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.22e-02 32 13 1 0.077 0.031 TF:M05757_0 tf 1 Factor: ZNF648; motif: NGKGGCAGAATS; match class: 0 1 Q99547 170 3.31e-02 5116 13 9 0.692 0.002 TF:M00131_0 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 0 1 Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q01780,Q13901,Q5RKV6 170 3.31e-02 9795 13 13 1.000 0.001 TF:M01878_1 tf 1 Factor: GATA-3; motif: AGATAA; match class: 1 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.32e-02 33 13 1 0.077 0.030 TF:M06093_0 tf 1 Factor: ZNF17; motif: KGGTCCAASRTT; match class: 0 1 Q15024 170 3.33e-02 286 13 2 0.154 0.007 TF:M04414_1 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 1 1 Q06265,Q8TF46 170 3.40e-02 3392 13 7 0.538 0.002 TF:M03872_0 tf 1 Factor: HNF-1beta; motif: GTTAATYATTAACY; match class: 0 1 Q15024,Q9NQT4,Q96B26,Q06265,Q99547,Q01780,Q13901 170 3.42e-02 34 13 1 0.077 0.029 TF:M06214_0 tf 1 Factor: ZNF33b; motif: GTWAAGCGGA; match class: 0 1 Q9NQT4 170 3.42e-02 34 13 1 0.077 0.029 TF:M06143_0 tf 1 Factor: ZNF16; motif: NGTKGCTTAAKA; match class: 0 1 Q06265 170 3.71e-02 634 13 3 0.231 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q9NQT5,Q99547,Q01780 170 3.71e-02 1307 13 4 0.308 0.003 TF:M00793_0 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 0 1 Q9NQT4,Q06265,Q13868,Q9Y3B2 170 3.72e-02 238 13 2 0.154 0.008 GO:0046649 BP 1 lymphocyte activation 1 Q9NQT5,Q5RKV6 170 3.76e-02 9890 13 13 1.000 0.001 TF:M01660_0 tf 1 Factor: GABPalpha; motif: CTTCCK; match class: 0 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 3.81e-02 38 13 1 0.077 0.026 TF:M04044_1 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 1 1 Q15024 170 3.82e-02 308 13 2 0.154 0.006 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 Q96B26,Q9Y3B2 170 3.96e-02 2706 13 6 0.462 0.002 TF:M01856_0 tf 1 Factor: AML3; motif: AACCACAN; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q13868,Q8TF46,Q13901 170 3.96e-02 2706 13 6 0.462 0.002 TF:M01759_0 tf 1 Factor: AML2; motif: AACCRCAA; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q13868,Q8TF46,Q13901 170 3.99e-02 9935 13 13 1.000 0.001 TF:M01884_1 tf 1 Factor: IRF-7; motif: AAGWGAA; match class: 1 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.01e-02 9 13 2 0.154 0.222 HP:0012473 hp 1 Tongue atrophy 1 Q9NQT5,Q96B26 170 4.01e-02 2714 13 6 0.462 0.002 TF:M04413_0 tf 1 Factor: NKX3-1; motif: NCCACTTAA; match class: 0 1 Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9NPD3 170 4.02e-02 2716 13 6 0.462 0.002 TF:M03562_0 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 0 1 Q15024,Q9NQT5,Q13868,Q8TF46,Q13901,Q5RKV6 170 4.10e-02 6267 13 10 0.769 0.002 TF:M04287_0 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 0 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 4.11e-02 8539 13 12 0.923 0.001 TF:M03797_0 tf 1 Factor: Msx-2; motif: TWWTTGGDGABN; match class: 0 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q5RKV6 170 4.17e-02 4491 13 9 0.692 0.002 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q15024,Q9NQT5,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 4.31e-02 43 13 1 0.077 0.023 TF:M05966_0 tf 1 Factor: ZFP14; motif: NNRGGAATAAAA; match class: 0 1 Q06265 170 4.33e-02 5354 13 10 0.769 0.002 HPA:006010_02 hpa 1 cerebellum; Purkinje cells[Uncertain,Medium] 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 4.44e-02 1382 13 4 0.308 0.003 TF:M01659_1 tf 1 Factor: Cdx-2; motif: BNNATAAANRN; match class: 1 1 Q15024,Q06265,Q8TF46,Q13901 170 4.50e-02 45 13 1 0.077 0.022 TF:M07090_0 tf 1 Factor: c-Fos; motif: NNTGASTCATN; match class: 0 1 Q8TF46 170 4.55e-02 8911 13 13 1.000 0.001 GO:0044424 CC 1 intracellular part 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 4.56e-02 549 13 4 0.308 0.007 MI:hsa-miR-181b mi 1 MI:hsa-miR-181b 1 Q9NQT5,Q13868,Q99547,Q8TF46 170 4.57e-02 1395 13 4 0.308 0.003 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q15024,Q99547,Q8TF46,Q5RKV6 170 4.63e-02 7444 13 11 0.846 0.001 TF:M04379_0 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 0 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 4.65e-02 552 13 4 0.308 0.007 MI:hsa-miR-181c mi 1 MI:hsa-miR-181c 1 Q9NQT5,Q13868,Q99547,Q8TF46 170 4.70e-02 47 13 1 0.077 0.021 TF:M00001_1 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 1 1 Q9NQT5 170 4.72e-02 4575 13 9 0.692 0.002 HPA:018010_01 hpa 1 hippocampus; glial cells[Uncertain,Low] 1 Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q01780,Q9NPD3,Q13901 170 4.80e-02 6339 13 11 0.846 0.002 HPA:035040_01 hpa 1 skin 1; melanocytes[Uncertain,Low] 1 Q15024,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901 170 4.90e-02 560 13 4 0.308 0.007 MI:hsa-miR-19a mi 1 MI:hsa-miR-19a 1 Q15024,Q96B26,Q01780,Q13901 170 4.99e-02 713 13 3 0.231 0.004 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q15024,Q9NQT5,Q99547 170 5.00e-02 5629 13 10 0.769 0.002 GO:0044444 CC 1 cytoplasmic part 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q8TF46,Q9Y3B2,Q9NPD3,Q5RKV6 170 5.00e-02 71 13 13 1.000 0.183 KEGG:03018 keg 1 RNA degradation 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q99547,Q8TF46,Q9Y3B2,Q01780,Q9NPD3,Q13901,Q5RKV6 170 5.00e-02 563 13 4 0.308 0.007 MI:hsa-miR-181d mi 1 MI:hsa-miR-181d 1 Q9NQT5,Q13868,Q99547,Q8TF46 170 5.00e-02 10 13 2 0.154 0.200 HP:0006999 hp 1 Basal ganglia gliosis 1 Q9NQT5,Q96B26 170 5.00e-02 1169 13 9 0.692 0.008 REAC:392499 rea 1 Metabolism of proteins 1 Q15024,Q9NQT4,Q9NQT5,Q96B26,Q06265,Q13868,Q9Y3B2,Q9NPD3,Q5RKV6 170 5.00e-02 1 13 1 0.077 1.000 CORUM:2004 cor 1 C1D homodimer protein 1 Q13901 170 5.00e-02 13 13 2 0.154 0.154 OMIM:607596 omi 1 Pontocerebellar Hypoplasia 1 Q9NQT5,Q96B26 171 6.51e-10 31 5 4 0.800 0.129 GO:0030049 BP 1 muscle filament sliding 1 P35609,P09493,P19237,P13533 171 6.51e-10 31 5 4 0.800 0.129 GO:0033275 BP 1 actin-myosin filament sliding 1 P35609,P09493,P19237,P13533 171 1.08e-08 61 5 4 0.800 0.066 GO:0070252 BP 1 actin-mediated cell contraction 1 P35609,P09493,P19237,P13533 171 2.79e-08 77 5 4 0.800 0.052 GO:0030048 BP 1 actin filament-based movement 1 P35609,P09493,P19237,P13533 171 3.41e-08 13 5 3 0.600 0.231 GO:0045214 BP 1 sarcomere organization 1 P35609,P09493,P13533 171 3.79e-08 83 5 4 0.800 0.048 GO:0030017 CC 1 sarcomere 1 P35609,P09493,P19237,P13533 171 6.28e-08 94 5 4 0.800 0.043 GO:0030016 CC 1 myofibril 1 P35609,P09493,P19237,P13533 171 6.55e-08 95 5 4 0.800 0.042 GO:0044449 CC 1 contractile fiber part 1 P35609,P09493,P19237,P13533 171 8.40e-08 101 5 4 0.800 0.040 GO:0043292 CC 1 contractile fiber 1 P35609,P09493,P19237,P13533 171 3.48e-07 27 5 3 0.600 0.111 GO:0030239 BP 1 myofibril assembly 1 P35609,P09493,P13533 171 5.95e-07 164 5 4 0.800 0.024 GO:0006936 BP 1 muscle contraction 1 P35609,P09493,P19237,P13533 171 1.08e-06 190 5 4 0.800 0.021 GO:0003012 BP 1 muscle system process 1 P35609,P09493,P19237,P13533 171 1.36e-06 42 5 3 0.600 0.071 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 P35609,P09493,P13533 171 1.69e-06 45 5 3 0.600 0.067 GO:0055002 BP 1 striated muscle cell development 1 P35609,P09493,P13533 171 2.94e-06 54 5 3 0.600 0.056 GO:0055001 BP 1 muscle cell development 1 P35609,P09493,P13533 171 3.47e-06 57 5 3 0.600 0.053 GO:0060048 BP 1 cardiac muscle contraction 1 P09493,P19237,P13533 171 3.77e-06 18 5 3 0.600 0.167 OMIM:192600 omi 1 Hypertrophic Cardiomyopathy 1 P35609,P09493,P13533 171 7.27e-06 306 5 4 0.800 0.013 GO:0015629 CC 1 actin cytoskeleton 1 P35609,P09493,P19237,P13533 171 7.99e-06 75 5 3 0.600 0.040 GO:0006941 BP 1 striated muscle contraction 1 P09493,P19237,P13533 171 9.72e-06 80 5 3 0.600 0.037 GO:0051146 BP 1 striated muscle cell differentiation 1 P35609,P09493,P13533 171 1.48e-05 92 5 3 0.600 0.033 GO:0031032 BP 1 actomyosin structure organization 1 P35609,P09493,P13533 171 2.55e-05 419 5 4 0.800 0.010 GO:0030029 BP 1 actin filament-based process 1 P35609,P09493,P19237,P13533 171 3.01e-05 33 5 3 0.600 0.091 HP:0006673 hp 1 Reduced systolic function 1 P35609,P09493,P13533 171 3.01e-05 33 5 3 0.600 0.091 HP:0001706 hp 1 Endocardial fibroelastosis 1 P35609,P09493,P13533 171 3.01e-05 33 5 3 0.600 0.091 HP:0006670 hp 1 Impaired myocardial contractility 1 P35609,P09493,P13533 171 3.93e-05 36 5 3 0.600 0.083 HP:0006685 hp 1 Endocardial fibrosis 1 P35609,P09493,P13533 171 3.93e-05 36 5 3 0.600 0.083 HP:0011713 hp 1 Left bundle branch block 1 P35609,P09493,P13533 171 4.01e-05 128 5 3 0.600 0.023 GO:0060047 BP 1 heart contraction 1 P09493,P19237,P13533 171 4.20e-05 130 5 3 0.600 0.023 GO:0003015 BP 1 heart process 1 P09493,P19237,P13533 171 4.64e-05 38 5 3 0.600 0.079 HP:0004971 hp 1 Pulmonary artery hypoplasia 1 P35609,P09493,P13533 171 4.81e-05 15 5 2 0.400 0.133 GO:0005865 CC 1 striated muscle thin filament 1 P09493,P19237 171 5.14e-05 139 5 3 0.600 0.022 GO:0042692 BP 1 muscle cell differentiation 1 P35609,P09493,P13533 171 5.23e-05 26 5 4 0.800 0.154 REAC:390522 rea 1 Striated Muscle Contraction 1 P35609,P09493,P19237,P13533 171 6.23e-05 17 5 2 0.400 0.118 GO:0036379 CC 1 myofilament 1 P09493,P19237 171 6.29e-05 42 5 3 0.600 0.071 HP:0001723 hp 1 Restrictive cardiomyopathy 1 P35609,P09493,P13533 171 7.77e-05 45 5 3 0.600 0.067 HP:0011712 hp 1 Right bundle branch block 1 P35609,P09493,P13533 171 9.45e-05 48 5 3 0.600 0.062 HP:0100578 hp 1 Lipoatrophy 1 P35609,P09493,P13533 171 9.45e-05 48 5 3 0.600 0.062 HP:0004749 hp 1 Atrial flutter 1 P35609,P09493,P13533 171 1.07e-04 50 5 3 0.600 0.060 HP:0011710 hp 1 Bundle branch block 1 P35609,P09493,P13533 171 1.20e-04 52 5 3 0.600 0.058 HP:0001279 hp 1 Syncope 1 P35609,P09493,P13533 171 1.37e-04 25 5 2 0.400 0.080 GO:0055010 BP 1 ventricular cardiac muscle tissue morphogenesis 1 P09493,P13533 171 1.43e-04 55 5 3 0.600 0.055 HP:0009125 hp 1 Lipodystrophy 1 P35609,P09493,P13533 171 1.49e-04 26 5 2 0.400 0.077 GO:0003229 BP 1 ventricular cardiac muscle tissue development 1 P09493,P13533 171 1.61e-04 27 5 2 0.400 0.074 GO:0008307 MF 1 structural constituent of muscle 1 P35609,P09493 171 1.68e-04 58 5 3 0.600 0.052 HP:0004756 hp 1 Ventricular tachycardia 1 P35609,P09493,P13533 171 1.77e-04 59 5 3 0.600 0.051 HP:0001699 hp 1 Sudden death 1 P35609,P09493,P13533 171 1.79e-04 211 5 3 0.600 0.014 GO:0008015 BP 1 blood circulation 1 P09493,P19237,P13533 171 1.82e-04 212 5 3 0.600 0.014 GO:0003013 BP 1 circulatory system process 1 P09493,P19237,P13533 171 1.86e-04 60 5 3 0.600 0.050 HP:0004306 hp 1 Abnormality of the endocardium 1 P35609,P09493,P13533 171 1.86e-04 60 5 3 0.600 0.050 HP:0001678 hp 1 Atrioventricular block 1 P35609,P09493,P13533 171 1.87e-04 214 5 3 0.600 0.014 GO:0044057 BP 1 regulation of system process 1 P09493,P19237,P13533 171 1.88e-04 693 5 4 0.800 0.006 GO:0003008 BP 1 system process 1 P35609,P09493,P19237,P13533 171 1.95e-04 217 5 3 0.600 0.014 GO:0061061 BP 1 muscle structure development 1 P35609,P09493,P13533 171 1.99e-04 30 5 2 0.400 0.067 GO:0055008 BP 1 cardiac muscle tissue morphogenesis 1 P09493,P13533 171 2.05e-04 62 5 3 0.600 0.048 HP:0001962 hp 1 Palpitations 1 P35609,P09493,P13533 171 2.41e-04 33 5 2 0.400 0.061 GO:0048644 BP 1 muscle organ morphogenesis 1 P09493,P13533 171 2.41e-04 33 5 2 0.400 0.061 GO:0060415 BP 1 muscle tissue morphogenesis 1 P09493,P13533 171 2.48e-04 66 5 3 0.600 0.045 HP:0012722 hp 1 Heart block 1 P35609,P09493,P13533 171 2.48e-04 66 5 3 0.600 0.045 HP:0005150 hp 1 Abnormal atrioventricular conduction 1 P35609,P09493,P13533 171 2.59e-04 67 5 3 0.600 0.045 HP:0005180 hp 1 Tricuspid regurgitation 1 P35609,P09493,P13533 171 2.59e-04 67 5 3 0.600 0.045 HP:0011462 hp 1 Young adult onset 1 P35609,P09493,P13533 171 2.59e-04 67 5 3 0.600 0.045 HP:0001653 hp 1 Mitral regurgitation 1 P35609,P09493,P13533 171 3.04e-04 37 5 2 0.400 0.054 GO:0003208 BP 1 cardiac ventricle morphogenesis 1 P09493,P13533 171 3.21e-04 72 5 3 0.600 0.042 HP:0005110 hp 1 Atrial fibrillation 1 P35609,P09493,P13533 171 3.35e-04 73 5 3 0.600 0.041 HP:0004308 hp 1 Ventricular arrhythmia 1 P35609,P09493,P13533 171 3.38e-04 39 5 2 0.400 0.051 GO:0043462 BP 1 regulation of ATPase activity 1 P09493,P13533 171 3.38e-04 39 5 2 0.400 0.051 GO:0002027 BP 1 regulation of heart rate 1 P09493,P13533 171 3.63e-04 75 5 3 0.600 0.040 HP:0001692 hp 1 Primary atrial arrhythmia 1 P35609,P09493,P13533 171 3.78e-04 76 5 3 0.600 0.039 HP:0004755 hp 1 Supraventricular tachycardia 1 P35609,P09493,P13533 171 3.93e-04 77 5 3 0.600 0.039 HP:0005115 hp 1 Supraventricular arrhythmia 1 P35609,P09493,P13533 171 4.51e-04 45 5 2 0.400 0.044 GO:0003231 BP 1 cardiac ventricle development 1 P09493,P13533 171 4.92e-04 83 5 3 0.600 0.036 HP:0001702 hp 1 Abnormality of the tricuspid valve 1 P35609,P09493,P13533 171 5.14e-04 48 5 2 0.400 0.042 GO:0003206 BP 1 cardiac chamber morphogenesis 1 P09493,P13533 171 6.08e-04 933 5 4 0.800 0.004 GO:0044430 CC 1 cytoskeletal part 1 P35609,P09493,P19237,P13533 171 6.27e-04 90 5 3 0.600 0.033 HP:0001297 hp 1 Stroke 1 P35609,P09493,P13533 171 6.48e-04 91 5 3 0.600 0.033 HP:0001712 hp 1 Left ventricular hypertrophy 1 P35609,P09493,P13533 171 6.76e-04 55 5 2 0.400 0.036 GO:0008217 BP 1 regulation of blood pressure 1 P09493,P13533 171 6.76e-04 55 5 2 0.400 0.036 GO:0003205 BP 1 cardiac chamber development 1 P09493,P13533 171 8.50e-04 1016 5 4 0.800 0.004 GO:0006928 BP 1 movement of cell or subcellular component 1 P35609,P09493,P19237,P13533 171 8.65e-04 358 5 3 0.600 0.008 GO:0030036 BP 1 actin cytoskeleton organization 1 P35609,P09493,P13533 171 9.64e-04 104 5 3 0.600 0.029 HP:0001711 hp 1 Abnormality of the left ventricle 1 P35609,P09493,P13533 171 9.92e-04 105 5 3 0.600 0.029 HP:0001680 hp 1 Coarctation of aorta 1 P35609,P09493,P13533 171 1.03e-03 68 5 2 0.400 0.029 GO:0006937 BP 1 regulation of muscle contraction 1 P09493,P19237 171 1.05e-03 382 5 3 0.600 0.008 GO:0048646 BP 1 anatomical structure formation involved in morphogenesis 1 P35609,P09493,P13533 171 1.05e-03 107 5 3 0.600 0.028 HP:0001649 hp 1 Tachycardia 1 P35609,P09493,P13533 171 1.05e-03 107 5 3 0.600 0.028 HP:0000982 hp 1 Palmoplantar keratoderma 1 P35609,P09493,P13533 171 1.05e-03 107 5 3 0.600 0.028 HP:0001714 hp 1 Ventricular hypertrophy 1 P35609,P09493,P13533 171 1.13e-03 71 5 2 0.400 0.028 GO:0048738 BP 1 cardiac muscle tissue development 1 P09493,P13533 171 1.14e-03 110 5 3 0.600 0.027 HP:0001645 hp 1 Sudden cardiac death 1 P35609,P09493,P13533 171 1.17e-03 111 5 3 0.600 0.027 HP:0009124 hp 1 Abnormality of adipose tissue 1 P35609,P09493,P13533 171 1.20e-03 112 5 3 0.600 0.027 HP:0001695 hp 1 Cardiac arrest 1 P35609,P09493,P13533 171 1.20e-03 112 5 3 0.600 0.027 HP:0001647 hp 1 Bicuspid aortic valve 1 P35609,P09493,P13533 171 1.27e-03 114 5 3 0.600 0.026 HP:0001644 hp 1 Dilated cardiomyopathy 1 P35609,P09493,P13533 171 1.32e-03 1 5 1 0.200 1.000 GO:1904753 BP 1 negative regulation of vascular associated smooth muscle cell migration 1 P09493 171 1.32e-03 1 5 1 0.200 1.000 GO:0003065 BP 1 positive regulation of heart rate by epinephrine 1 P09493 171 1.32e-03 1 5 1 0.200 1.000 GO:0007522 BP 1 visceral muscle development 1 P13533 171 1.32e-03 1 5 1 0.200 1.000 GO:0070080 MF 1 titin Z domain binding 1 P35609 171 1.33e-03 414 5 3 0.600 0.007 GO:0005198 MF 1 structural molecule activity 1 P35609,P09493,Q8TDM6 171 1.40e-03 118 5 3 0.600 0.025 HP:0004414 hp 1 Abnormality of the pulmonary artery 1 P35609,P09493,P13533 171 1.62e-03 85 5 2 0.400 0.024 GO:0090257 BP 1 regulation of muscle system process 1 P09493,P19237 171 1.64e-03 445 5 3 0.600 0.007 GO:0070925 BP 1 organelle assembly 1 P35609,P09493,P13533 171 1.65e-03 1204 5 4 0.800 0.003 GO:0005856 CC 1 cytoskeleton 1 P35609,P09493,P19237,P13533 171 1.81e-03 90 5 2 0.400 0.022 GO:0003007 BP 1 heart morphogenesis 1 P09493,P13533 171 1.82e-03 129 5 3 0.600 0.023 HP:0001633 hp 1 Abnormality of the mitral valve 1 P35609,P09493,P13533 171 2.08e-03 135 5 3 0.600 0.022 HP:0003457 hp 1 EMG abnormality 1 P35609,P09493,P13533 171 2.12e-03 485 5 3 0.600 0.006 GO:0008092 MF 1 cytoskeletal protein binding 1 P35609,P09493,Q8TDM6 171 2.53e-03 515 5 3 0.600 0.006 GO:0032989 BP 1 cellular component morphogenesis 1 P35609,P09493,P13533 171 2.54e-03 1 5 1 0.200 1.000 OMIM:611878 omi 1 CARDIOMYOPATHY, DILATED, 1Y; CMD1YLEFT VENTRICULAR NONCOMPACTION 9, INCLUDED; LVNC9, INCLUDED 1 P09493 171 2.54e-03 1 5 1 0.200 1.000 OMIM:613252 omi 1 CARDIOMYOPATHY, DILATED, 1EE; CMD1EE 1 P13533 171 2.54e-03 1 5 1 0.200 1.000 OMIM:614090 omi 1 SICK SINUS SYNDROME 3, SUSCEPTIBILITY TO; SSS3 1 P13533 171 2.54e-03 1 5 1 0.200 1.000 OMIM:115196 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3; CMH3 1 P09493 171 2.54e-03 1 5 1 0.200 1.000 OMIM:614089 omi 1 ATRIAL SEPTAL DEFECT 3; ASD3 1 P13533 171 2.54e-03 1 5 1 0.200 1.000 OMIM:612158 omi 1 CARDIOMYOPATHY, DILATED, 1AA, WITH OR WITHOUT LEFT VENTRICULAR NONCOMPACTION;CMD1AACARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 23, WITH OR WITHOUT VENTRICULARNONCOMPACTION, INCLUDED; CMH23, INCLUDED 1 P35609 171 2.54e-03 1 5 1 0.200 1.000 OMIM:613251 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 14; CMH14 1 P13533 171 2.65e-03 2 5 1 0.200 0.500 GO:0051373 MF 1 FATZ binding 1 P35609 171 2.65e-03 2 5 1 0.200 0.500 GO:0001996 BP 1 positive regulation of heart rate by epinephrine-norepinephrine 1 P09493 171 2.65e-03 2 5 1 0.200 0.500 GO:0051695 BP 1 actin filament uncapping 1 P35609 171 2.65e-03 2 5 1 0.200 0.500 GO:0086097 BP 1 phospholipase C-activating angiotensin-activated signaling pathway 1 P35609 171 2.65e-03 2 5 1 0.200 0.500 GO:0032059 CC 1 bleb 1 P09493 171 2.65e-03 109 5 2 0.400 0.018 GO:0014706 BP 1 striated muscle tissue development 1 P09493,P13533 171 2.70e-03 110 5 2 0.400 0.018 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 P35609,P09493 171 2.84e-03 150 5 3 0.600 0.020 HP:0001874 hp 1 Abnormality of neutrophils 1 P35609,P09493,P13533 171 2.85e-03 113 5 2 0.400 0.018 GO:0060537 BP 1 muscle tissue development 1 P09493,P13533 171 3.00e-03 116 5 2 0.400 0.017 GO:0008016 BP 1 regulation of heart contraction 1 P09493,P13533 171 3.07e-03 154 5 3 0.600 0.019 HP:0003198 hp 1 Myopathy 1 P35609,P09493,P13533 171 3.13e-03 155 5 3 0.600 0.019 HP:0001635 hp 1 Congestive heart failure 1 P35609,P09493,P13533 171 3.31e-03 158 5 3 0.600 0.019 HP:0004930 hp 1 Abnormality of the pulmonary vasculature 1 P35609,P09493,P13533 171 3.43e-03 124 5 2 0.400 0.016 GO:0007517 BP 1 muscle organ development 1 P09493,P13533 171 3.76e-03 165 5 3 0.600 0.018 HP:0001911 hp 1 Abnormality of granulocytes 1 P35609,P09493,P13533 171 3.82e-03 166 5 3 0.600 0.018 HP:0006705 hp 1 Abnormality of the atrioventricular valves 1 P35609,P09493,P13533 171 3.97e-03 3 5 1 0.200 0.333 GO:0055009 BP 1 atrial cardiac muscle tissue morphogenesis 1 P13533 171 3.97e-03 3 5 1 0.200 0.333 GO:0030035 BP 1 microspike assembly 1 P35609 171 3.97e-03 3 5 1 0.200 0.333 GO:0003228 BP 1 atrial cardiac muscle tissue development 1 P13533 171 3.97e-03 3 5 1 0.200 0.333 GO:1904706 BP 1 negative regulation of vascular smooth muscle cell proliferation 1 P09493 171 4.17e-03 171 5 3 0.600 0.018 HP:0100659 hp 1 Abnormality of the cerebral vasculature 1 P35609,P09493,P13533 171 4.42e-03 141 5 2 0.400 0.014 GO:1903522 BP 1 regulation of blood circulation 1 P09493,P13533 171 4.84e-03 180 5 3 0.600 0.017 HP:0003701 hp 1 Proximal muscle weakness 1 P35609,P09493,P13533 171 4.84e-03 180 5 3 0.600 0.017 HP:0010974 hp 1 Abnormality of myeloid leukocytes 1 P35609,P09493,P13533 171 5.29e-03 4 5 1 0.200 0.250 GO:0003321 BP 1 positive regulation of blood pressure by epinephrine-norepinephrine 1 P09493 171 5.29e-03 4 5 1 0.200 0.250 GO:0007512 BP 1 adult heart development 1 P13533 171 5.29e-03 4 5 1 0.200 0.250 GO:0017018 MF 1 myosin phosphatase activity 1 P13533 171 5.29e-03 4 5 1 0.200 0.250 GO:2001137 BP 1 positive regulation of endocytic recycling 1 P35609 171 5.29e-03 4 5 1 0.200 0.250 GO:0001993 BP 1 regulation of systemic arterial blood pressure by norepinephrine-epinephrine 1 P09493 171 5.29e-03 4 5 1 0.200 0.250 GO:0005862 CC 1 muscle thin filament tropomyosin 1 P09493 171 5.41e-03 187 5 3 0.600 0.016 HP:0000962 hp 1 Hyperkeratosis 1 P35609,P09493,P13533 171 5.65e-03 678 5 3 0.600 0.004 GO:0007155 BP 1 cell adhesion 1 P35609,P09493,Q8TDM6 171 5.80e-03 684 5 3 0.600 0.004 GO:0022610 BP 1 biological adhesion 1 P35609,P09493,Q8TDM6 171 6.20e-03 196 5 3 0.600 0.015 HP:0001646 hp 1 Abnormality of the aortic valve 1 P35609,P09493,P13533 171 6.41e-03 170 5 2 0.400 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 P35609,P09493 171 6.62e-03 5 5 1 0.200 0.200 GO:1904738 BP 1 vascular associated smooth muscle cell migration 1 P09493 171 6.62e-03 5 5 1 0.200 0.200 GO:0003062 BP 1 regulation of heart rate by chemical signal 1 P09493 171 6.62e-03 5 5 1 0.200 0.200 GO:0048739 BP 1 cardiac muscle fiber development 1 P13533 171 6.62e-03 5 5 1 0.200 0.200 GO:0010460 BP 1 positive regulation of heart rate 1 P09493 171 6.62e-03 5 5 1 0.200 0.200 GO:1904752 BP 1 regulation of vascular associated smooth muscle cell migration 1 P09493 171 6.71e-03 174 5 2 0.400 0.011 GO:0007507 BP 1 heart development 1 P09493,P13533 171 6.73e-03 2 5 1 0.200 0.500 HP:0005155 hp 1 Ventricular escape rhythms 1 P13533 171 7.26e-03 207 5 3 0.600 0.014 HP:0003621 hp 1 Juvenile onset 1 P35609,P09493,P13533 171 7.36e-03 208 5 3 0.600 0.014 HP:0001679 hp 1 Abnormality of the aorta 1 P35609,P09493,P13533 171 7.81e-03 758 5 3 0.600 0.004 GO:0007010 BP 1 cytoskeleton organization 1 P35609,P09493,P13533 171 7.89e-03 213 5 3 0.600 0.014 HP:0003581 hp 1 Adult onset 1 P35609,P09493,P13533 171 7.94e-03 6 5 1 0.200 0.167 GO:2000009 BP 1 negative regulation of protein localization to cell surface 1 P35609 171 7.94e-03 6 5 1 0.200 0.167 GO:2001135 BP 1 regulation of endocytic recycling 1 P35609 171 7.94e-03 6 5 1 0.200 0.167 GO:0005861 CC 1 troponin complex 1 P19237 171 8.23e-03 193 5 2 0.400 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 P35609,P09493 171 8.81e-03 790 5 3 0.600 0.004 GO:0048468 BP 1 cell development 1 P35609,P09493,P13533 171 9.26e-03 7 5 1 0.200 0.143 GO:0045777 BP 1 positive regulation of blood pressure 1 P09493 171 9.26e-03 7 5 1 0.200 0.143 GO:0038166 BP 1 angiotensin-activated signaling pathway 1 P35609 171 9.60e-03 228 5 3 0.600 0.013 HP:0001639 hp 1 Hypertrophic cardiomyopathy 1 P35609,P09493,P13533 171 9.90e-03 212 5 2 0.400 0.009 GO:0007015 BP 1 actin filament organization 1 P35609,P09493 171 1.01e-02 3 5 1 0.200 0.333 HP:0011704 hp 1 Sick sinus syndrome 1 P13533 171 1.06e-02 8 5 1 0.200 0.125 GO:1904705 BP 1 regulation of vascular smooth muscle cell proliferation 1 P09493 171 1.06e-02 8 5 1 0.200 0.125 GO:1990776 BP 1 response to angiotensin 1 P35609 171 1.06e-02 8 5 1 0.200 0.125 GO:1904385 BP 1 cellular response to angiotensin 1 P35609 171 1.06e-02 8 5 1 0.200 0.125 GO:1901017 BP 1 negative regulation of potassium ion transmembrane transporter activity 1 P35609 171 1.06e-02 8 5 1 0.200 0.125 GO:0045823 BP 1 positive regulation of heart contraction 1 P09493 171 1.06e-02 8 5 1 0.200 0.125 GO:1990874 BP 1 vascular smooth muscle cell proliferation 1 P09493 171 1.10e-02 1960 5 4 0.800 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P35609,P09493,P19237,P13533 171 1.10e-02 1960 5 4 0.800 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P35609,P09493,P19237,P13533 171 1.10e-02 239 5 3 0.600 0.013 HP:0040006 hp 1 Mortality/Aging 1 P35609,P09493,P13533 171 1.10e-02 239 5 3 0.600 0.013 HP:0011420 hp 1 Age of death 1 P35609,P09493,P13533 171 1.19e-02 9 5 1 0.200 0.111 GO:0030898 MF 1 actin-dependent ATPase activity 1 P13533 171 1.19e-02 9 5 1 0.200 0.111 GO:0031143 CC 1 pseudopodium 1 P35609 171 1.19e-02 9 5 1 0.200 0.111 GO:0030836 BP 1 positive regulation of actin filament depolymerization 1 P35609 171 1.19e-02 9 5 1 0.200 0.111 GO:0031432 MF 1 titin binding 1 P35609 171 1.27e-02 61 5 2 0.400 0.033 KEGG:04260 keg 1 Cardiac muscle contraction 1 P09493,P13533 171 1.29e-02 253 5 3 0.600 0.012 HP:0011368 hp 1 Epidermal thickening 1 P35609,P09493,P13533 171 1.32e-02 10 5 1 0.200 0.100 GO:1901380 BP 1 negative regulation of potassium ion transmembrane transport 1 P35609 171 1.32e-02 10 5 1 0.200 0.100 GO:1901018 BP 1 positive regulation of potassium ion transmembrane transporter activity 1 P35609 171 1.32e-02 10 5 1 0.200 0.100 GO:0014912 BP 1 negative regulation of smooth muscle cell migration 1 P09493 171 1.34e-02 4 5 1 0.200 0.250 HP:0001684 hp 1 Secundum atrial septal defect 1 P13533 171 1.38e-02 259 5 3 0.600 0.012 HP:0011675 hp 1 Arrhythmia 1 P35609,P09493,P13533 171 1.39e-02 434 5 2 0.400 0.005 MI:mmu-miR-463 mi 1 MI:mmu-miR-463 1 P09493,P19237 171 1.40e-02 437 5 2 0.400 0.005 MI:hsa-miR-302d* mi 1 MI:hsa-miR-302d* 1 P09493,P19237 171 1.42e-02 439 5 2 0.400 0.005 MI:hsa-miR-302b* mi 1 MI:hsa-miR-302b* 1 P09493,P19237 171 1.43e-02 441 5 2 0.400 0.005 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 P09493,P19237 171 1.49e-02 66 5 2 0.400 0.030 KEGG:05410 keg 1 Hypertrophic cardiomyopathy (HCM) 1 P09493,P13533 171 1.53e-02 265 5 2 0.400 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 P35609,P09493 171 1.56e-02 461 5 2 0.400 0.004 MI:hsa-miR-589 mi 1 MI:hsa-miR-589 1 P09493,P19237 171 1.58e-02 269 5 2 0.400 0.007 GO:0048729 BP 1 tissue morphogenesis 1 P09493,P13533 171 1.59e-02 12 5 1 0.200 0.083 GO:0043267 BP 1 negative regulation of potassium ion transport 1 P35609 171 1.59e-02 12 5 1 0.200 0.083 GO:1901881 BP 1 positive regulation of protein depolymerization 1 P35609 171 1.59e-02 12 5 1 0.200 0.083 GO:0003209 BP 1 cardiac atrium morphogenesis 1 P13533 171 1.59e-02 12 5 1 0.200 0.083 GO:0002026 BP 1 regulation of the force of heart contraction 1 P13533 171 1.59e-02 12 5 1 0.200 0.083 GO:0048662 BP 1 negative regulation of smooth muscle cell proliferation 1 P09493 171 1.59e-02 466 5 2 0.400 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 P09493,P19237 171 1.69e-02 278 5 3 0.600 0.011 HP:0001072 hp 1 Thickened skin 1 P35609,P09493,P13533 171 1.72e-02 13 5 1 0.200 0.077 GO:1901381 BP 1 positive regulation of potassium ion transmembrane transport 1 P35609 171 1.72e-02 71 5 2 0.400 0.028 KEGG:05414 keg 1 Dilated cardiomyopathy 1 P09493,P13533 171 1.76e-02 491 5 2 0.400 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 P09493,P19237 171 1.82e-02 289 5 2 0.400 0.007 GO:0008285 BP 1 negative regulation of cell proliferation 1 P09493,Q8TDM6 171 1.85e-02 14 5 1 0.200 0.071 GO:0003230 BP 1 cardiac atrium development 1 P13533 171 1.98e-02 15 5 1 0.200 0.067 GO:0005859 CC 1 muscle myosin complex 1 P13533 171 2.07e-02 535 5 2 0.400 0.004 MI:hsa-miR-181a mi 1 MI:hsa-miR-181a 1 P35609,P09493 171 2.08e-02 536 5 2 0.400 0.004 MI:hsa-miR-296-3p mi 1 MI:hsa-miR-296-3p 1 P09493,P19237 171 2.11e-02 16 5 1 0.200 0.062 GO:0048747 BP 1 muscle fiber development 1 P13533 171 2.11e-02 16 5 1 0.200 0.062 GO:2001259 BP 1 positive regulation of cation channel activity 1 P35609 171 2.11e-02 16 5 1 0.200 0.062 GO:0043243 BP 1 positive regulation of protein complex disassembly 1 P35609 171 2.20e-02 552 5 2 0.400 0.004 MI:hsa-miR-181c mi 1 MI:hsa-miR-181c 1 P35609,P09493 171 2.20e-02 305 5 3 0.600 0.010 HP:0001654 hp 1 Abnormality of the heart valves 1 P35609,P09493,P13533 171 2.27e-02 9 5 1 0.200 0.111 OMIM:604169 omi 1 Left Ventricular Noncompaction 1 P09493 171 2.32e-02 1107 5 3 0.600 0.003 GO:0009653 BP 1 anatomical structure morphogenesis 1 P35609,P09493,P13533 171 2.38e-02 18 5 1 0.200 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 P35609 171 2.38e-02 18 5 1 0.200 0.056 GO:0000146 MF 1 microfilament motor activity 1 P13533 171 2.38e-02 18 5 1 0.200 0.056 GO:0030159 MF 1 receptor signaling complex scaffold activity 1 Q8TDM6 171 2.38e-02 18 5 1 0.200 0.056 GO:0055013 BP 1 cardiac muscle cell development 1 P13533 171 2.38e-02 18 5 1 0.200 0.056 GO:0043268 BP 1 positive regulation of potassium ion transport 1 P35609 171 2.51e-02 19 5 1 0.200 0.053 GO:0003009 BP 1 skeletal muscle contraction 1 P19237 171 2.51e-02 19 5 1 0.200 0.053 GO:0014910 BP 1 regulation of smooth muscle cell migration 1 P09493 171 2.52e-02 594 5 2 0.400 0.003 MI:mmu-miR-466b-5p mi 1 MI:mmu-miR-466b-5p 1 P09493,P19237 171 2.61e-02 348 5 2 0.400 0.006 GO:0009887 BP 1 animal organ morphogenesis 1 P09493,P13533 171 2.64e-02 20 5 1 0.200 0.050 GO:0016460 CC 1 myosin II complex 1 P13533 171 2.64e-02 20 5 1 0.200 0.050 GO:0055006 BP 1 cardiac cell development 1 P13533 171 2.70e-02 1168 5 3 0.600 0.003 GO:1902589 BP 1 single-organism organelle organization 1 P35609,P09493,P13533 171 2.77e-02 21 5 1 0.200 0.048 GO:0050881 BP 1 musculoskeletal movement 1 P19237 171 2.77e-02 21 5 1 0.200 0.048 GO:0050879 BP 1 multicellular organismal movement 1 P19237 171 2.79e-02 360 5 2 0.400 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 P35609,P09493 171 2.80e-02 628 5 2 0.400 0.003 MI:hsa-miR-519b-3p mi 1 MI:hsa-miR-519b-3p 1 P09493,P19237 171 2.82e-02 333 5 3 0.600 0.009 HP:0001638 hp 1 Cardiomyopathy 1 P35609,P09493,P13533 171 2.86e-02 635 5 2 0.400 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 P09493,P19237 171 2.89e-02 638 5 2 0.400 0.003 MI:hsa-miR-519c-3p mi 1 MI:hsa-miR-519c-3p 1 P09493,P19237 171 2.90e-02 22 5 1 0.200 0.045 GO:0051496 BP 1 positive regulation of stress fiber assembly 1 P09493 171 2.90e-02 22 5 1 0.200 0.045 GO:0030834 BP 1 regulation of actin filament depolymerization 1 P35609 171 2.90e-02 22 5 1 0.200 0.045 GO:0003044 BP 1 regulation of systemic arterial blood pressure mediated by a chemical signal 1 P09493 171 2.97e-02 372 5 2 0.400 0.005 GO:0072359 BP 1 circulatory system development 1 P09493,P13533 171 3.01e-02 9 5 1 0.200 0.111 HP:0001688 hp 1 Sinus bradycardia 1 P13533 171 3.09e-02 344 5 3 0.600 0.009 HP:0001881 hp 1 Abnormality of leukocytes 1 P35609,P09493,P13533 171 3.09e-02 344 5 3 0.600 0.009 HP:0010987 hp 1 Abnormality of cellular immune system 1 P35609,P09493,P13533 171 3.17e-02 24 5 1 0.200 0.042 GO:0031529 BP 1 ruffle organization 1 P09493 171 3.17e-02 24 5 1 0.200 0.042 GO:0014909 BP 1 smooth muscle cell migration 1 P09493 171 3.24e-02 350 5 3 0.600 0.009 HP:0001637 hp 1 Abnormality of the myocardium 1 P35609,P09493,P13533 171 3.30e-02 25 5 1 0.200 0.040 GO:1903524 BP 1 positive regulation of blood circulation 1 P09493 171 3.30e-02 25 5 1 0.200 0.040 GO:0032781 BP 1 positive regulation of ATPase activity 1 P09493 171 3.37e-02 1263 5 3 0.600 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 P09493,P19237,P13533 171 3.43e-02 26 5 1 0.200 0.038 GO:1901016 BP 1 regulation of potassium ion transmembrane transporter activity 1 P35609 171 3.43e-02 26 5 1 0.200 0.038 GO:0032456 BP 1 endocytic recycling 1 P35609 171 3.56e-02 27 5 1 0.200 0.037 GO:0030042 BP 1 actin filament depolymerization 1 P35609 171 3.56e-02 27 5 1 0.200 0.037 GO:0032233 BP 1 positive regulation of actin filament bundle assembly 1 P09493 171 3.56e-02 27 5 1 0.200 0.037 GO:0014812 BP 1 muscle cell migration 1 P09493 171 3.57e-02 409 5 2 0.400 0.005 GO:0044463 CC 1 cell projection part 1 P35609,P09493 171 3.68e-02 11 5 1 0.200 0.091 HP:0011702 hp 1 Abnormal electrophysiology of sinoatrial node origin 1 P13533 171 3.69e-02 28 5 1 0.200 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 P35609 171 3.69e-02 28 5 1 0.200 0.036 GO:0016459 CC 1 myosin complex 1 P13533 171 3.76e-02 2707 5 4 0.800 0.001 GO:0005829 CC 1 cytosol 1 P35609,P09493,P19237,P13533 171 3.82e-02 29 5 1 0.200 0.034 GO:0044309 CC 1 neuron spine 1 P35609 171 3.82e-02 29 5 1 0.200 0.034 GO:0043197 CC 1 dendritic spine 1 P35609 171 3.95e-02 30 5 1 0.200 0.033 GO:1904063 BP 1 negative regulation of cation transmembrane transport 1 P35609 171 4.01e-02 12 5 1 0.200 0.083 HP:0011664 hp 1 Left ventricular noncompaction cardiomyopathy 1 P09493 171 4.08e-02 31 5 1 0.200 0.032 GO:0001725 CC 1 stress fiber 1 P09493 171 4.08e-02 31 5 1 0.200 0.032 GO:0003073 BP 1 regulation of systemic arterial blood pressure 1 P09493 171 4.08e-02 31 5 1 0.200 0.032 GO:0055007 BP 1 cardiac muscle cell differentiation 1 P13533 171 4.08e-02 31 5 1 0.200 0.032 GO:0097517 CC 1 contractile actin filament bundle 1 P09493 171 4.13e-02 382 5 3 0.600 0.008 HP:0011004 hp 1 Abnormality of the systemic arterial tree 1 P35609,P09493,P13533 171 4.15e-02 111 5 2 0.400 0.018 KEGG:04530 keg 1 Tight junction 1 P35609,P13533 171 4.18e-02 444 5 2 0.400 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P35609,P09493 171 4.19e-02 384 5 3 0.600 0.008 HP:0001417 hp 1 X-linked inheritance 1 P35609,P09493,P13533 171 4.29e-02 387 5 3 0.600 0.008 HP:0001713 hp 1 Abnormality of cardiac ventricle 1 P35609,P09493,P13533 171 4.32e-02 388 5 3 0.600 0.008 HP:0010985 hp 1 Gonosomal inheritance 1 P35609,P09493,P13533 171 4.35e-02 33 5 1 0.200 0.030 GO:0034394 BP 1 protein localization to cell surface 1 P35609 171 4.40e-02 1388 5 3 0.600 0.002 GO:0065009 BP 1 regulation of molecular function 1 P35609,P09493,P13533 171 4.48e-02 34 5 1 0.200 0.029 GO:1901879 BP 1 regulation of protein depolymerization 1 P35609 171 4.48e-02 34 5 1 0.200 0.029 GO:0032432 CC 1 actin filament bundle 1 P09493 171 4.61e-02 35 5 1 0.200 0.029 GO:0032414 BP 1 positive regulation of ion transmembrane transporter activity 1 P35609 171 4.61e-02 35 5 1 0.200 0.029 GO:0032410 BP 1 negative regulation of transporter activity 1 P35609 171 4.61e-02 35 5 1 0.200 0.029 GO:1901379 BP 1 regulation of potassium ion transmembrane transport 1 P35609 171 4.61e-02 35 5 1 0.200 0.029 GO:0048660 BP 1 regulation of smooth muscle cell proliferation 1 P09493 171 4.74e-02 36 5 1 0.200 0.028 GO:0007200 BP 1 phospholipase C-activating G-protein coupled receptor signaling pathway 1 P35609 171 4.74e-02 36 5 1 0.200 0.028 GO:0034766 BP 1 negative regulation of ion transmembrane transport 1 P35609 171 4.87e-02 37 5 1 0.200 0.027 GO:0048659 BP 1 smooth muscle cell proliferation 1 P09493 171 4.87e-02 37 5 1 0.200 0.027 GO:0042641 CC 1 actomyosin 1 P09493 171 4.87e-02 37 5 1 0.200 0.027 GO:0051492 BP 1 regulation of stress fiber assembly 1 P09493 171 5.00e-02 476 5 3 0.600 0.006 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P35609,P09493,P13533 171 5.00e-02 20 5 1 0.200 0.050 OMIM:115200 omi 1 Dilated Cardiomyopathy 1 P13533 171 5.00e-02 15 5 1 0.200 0.067 HP:0012817 hp 1 Noncompaction cardiomyopathy 1 P09493 171 5.00e-02 122 5 2 0.400 0.016 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 P09493,P13533 171 5.00e-02 45 5 2 0.400 0.044 TF:M06555_0 tf 1 Factor: ZNF721; motif: NGGTGTGGGTGC; match class: 0 1 P09493,P13533 171 5.00e-02 38 5 1 0.200 0.026 GO:0001701 BP 1 in utero embryonic development 1 P13533 171 5.00e-02 138 5 4 0.800 0.029 REAC:397014 rea 1 Muscle contraction 1 P35609,P09493,P19237,P13533 171 5.00e-02 38 5 1 0.200 0.026 GO:0034763 BP 1 negative regulation of transmembrane transport 1 P35609 172 6.26e-03 4 2 1 0.500 0.250 REAC:2142688 rea 1 Synthesis of 5-eicosatetraenoic acids 1 P36969 172 6.26e-03 4 2 1 0.500 0.250 REAC:2142770 rea 1 Synthesis of 15-eicosatetraenoic acid derivatives 1 P36969 172 7.83e-03 5 2 1 0.500 0.200 REAC:2142712 rea 1 Synthesis of 12-eicosatetraenoic acid derivatives 1 P36969 172 2.03e-02 8 2 1 0.500 0.125 GO:0019372 BP 1 lipoxygenase pathway 1 P36969 172 3.05e-02 12 2 1 0.500 0.083 GO:0004602 MF 1 glutathione peroxidase activity 1 P36969 172 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P36969,P49773 172 5.00e-02 348 2 2 1.000 0.006 MI:hsa-miR-15a* mi 1 MI:hsa-miR-15a* 1 P36969,P49773 172 5.00e-02 1 2 1 0.500 1.000 HP:0006059 hp 1 Cone-shaped metacarpal epiphyses 1 P36969 172 5.00e-02 1 2 1 0.500 1.000 HP:0007187 hp 1 Focal lissencephaly 1 P36969 172 5.00e-02 32 2 1 0.500 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 P36969 172 5.00e-02 1 2 1 0.500 1.000 HP:0004688 hp 1 Irregular tarsal bones 1 P36969 172 5.00e-02 1 2 1 0.500 1.000 HP:0008798 hp 1 Widened sacrosciatic notch 1 P36969 172 5.00e-02 674 2 2 1.000 0.003 GO:0019637 BP 1 organophosphate metabolic process 1 P36969,P49773 172 5.00e-02 45 2 1 0.500 0.022 KEGG:00480 keg 1 Glutathione metabolism 1 P36969 172 5.00e-02 1 2 1 0.500 1.000 OMIM:137200 omi 1 NEUROMYOTONIA AND AXONAL NEUROPATHY, AUTOSOMAL RECESSIVE; NMAN;;GAMSTORP-WOHLFART SYNDROME;;MYOKYMIA, MYOTONIA, AND MUSCLE WASTING 1 P49773 173 4.14e-03 422 3 2 0.667 0.005 MI:hsa-miR-512-3p mi 1 MI:hsa-miR-512-3p 1 O43734,Q15274 173 4.91e-03 460 3 2 0.667 0.004 MI:hsa-miR-674 mi 1 MI:hsa-miR-674 1 O43734,Q15274 173 5.57e-03 490 3 2 0.667 0.004 MI:hsa-miR-371-5p mi 1 MI:hsa-miR-371-5p 1 O43734,Q15274 173 6.16e-03 516 3 2 0.667 0.004 MI:hsa-miR-96 mi 1 MI:hsa-miR-96 1 O43734,Q15274 173 7.15e-03 1 3 1 0.333 1.000 GO:0004514 MF 1 nicotinate-nucleotide diphosphorylase (carboxylating) activity 1 Q15274 173 7.15e-03 1 3 1 0.333 1.000 GO:0034213 BP 1 quinolinate catabolic process 1 Q15274 173 1.25e-02 1 3 1 0.333 1.000 OMIM:614070 omi 1 PSORIASIS 13, SUSCEPTIBILITY TO; PSORS13 1 O43734 173 1.25e-02 1 3 1 0.333 1.000 OMIM:615527 omi 1 CANDIDIASIS, FAMILIAL, 8; CANDF8;;CANDIDIASIS, FAMILIAL CHRONIC MUCOCUTANEOUS, AUTOSOMAL RECESSIVE 1 O43734 173 1.83e-02 867 3 2 0.667 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 O43734,Q9HCJ3 173 2.18e-02 3017 3 3 1.000 0.001 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 O43734,Q15274,Q9HCJ3 173 2.30e-02 1392 3 3 1.000 0.002 TF:M04315_1 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 1 1 O43734,Q15274,Q9HCJ3 173 2.68e-02 3233 3 3 1.000 0.001 HPA:041010_02 hpa 1 spleen; cells in red pulp[Uncertain,Medium] 1 O43734,Q15274,Q9HCJ3 173 2.86e-02 4 3 1 0.333 0.250 GO:0046874 BP 1 quinolinate metabolic process 1 Q15274 173 2.86e-02 4 3 1 0.333 0.250 HP:0012204 hp 1 Recurrent vulvovaginal candidiasis 1 O43734 173 2.86e-02 4 3 1 0.333 0.250 HP:0012203 hp 1 Onychomycosis 1 O43734 173 3.57e-02 5 3 1 0.333 0.200 GO:0072526 BP 1 pyridine-containing compound catabolic process 1 Q15274 173 3.57e-02 5 3 1 0.333 0.200 HP:0009098 hp 1 Chronic oral candidiasis 1 O43734 173 3.58e-02 3559 3 3 1.000 0.001 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 O43734,Q15274,Q9HCJ3 173 3.68e-02 339 3 2 0.667 0.006 TF:M06046_0 tf 1 Factor: ZNF195; motif: NGGAGAAGCCGW; match class: 0 1 O43734,Q9HCJ3 173 4.66e-02 1408 3 2 0.667 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 O43734,Q9HCJ3 173 5.00e-02 4 3 1 0.333 0.250 OMIM:114580 omi 1 Candidiasis 1 O43734 173 5.00e-02 7 3 1 0.333 0.143 GO:0009435 BP 1 NAD biosynthetic process 1 Q15274 173 5.00e-02 22 3 1 0.333 0.045 KEGG:00760 keg 1 Nicotinate and nicotinamide metabolism 1 Q15274 173 5.00e-02 7 3 1 0.333 0.143 HP:0002958 hp 1 Immune dysregulation 1 O43734 173 5.00e-02 10 3 1 0.333 0.100 REAC:196807 rea 1 Nicotinate metabolism 1 Q15274 173 5.00e-02 1802 3 3 1.000 0.002 TF:M04315_0 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 0 1 O43734,Q15274,Q9HCJ3 174 8.16e-03 6 4 1 0.250 0.167 REAC:70921 rea 1 Histidine catabolism 1 Q8N4J0 174 1.00e-02 1 4 1 0.250 1.000 OMIM:177735 omi 1 PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT; PHA1A;;PHA I, AUTOSOMAL DOMINANT 1 P08235 174 1.00e-02 1 4 1 0.250 1.000 OMIM:300953 omi 1 TRICHOTHIODYSTROPHY 5, NONPHOTOSENSITIVE; TTD5 1 O15541 174 1.00e-02 1 4 1 0.250 1.000 OMIM:605115 omi 1 HYPERTENSION, EARLY-ONSET, AUTOSOMAL DOMINANT, WITH SEVERE EXACERBATIONIN PREGNANCY 1 P08235 174 1.11e-02 1 4 1 0.250 1.000 TF:M05893_1 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 1 1 P08235 174 1.12e-02 500 4 2 0.500 0.004 MI:hsa-miR-524-5p mi 1 MI:hsa-miR-524-5p 1 O15541,Q8N4J0 174 1.45e-02 570 4 2 0.500 0.004 MI:hsa-miR-520d-5p mi 1 MI:hsa-miR-520d-5p 1 O15541,Q8N4J0 174 1.71e-02 3907 4 4 1.000 0.001 HPA:012010_01 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Low] 1 O15541,P08235,Q8N4J0,Q96B70 174 1.92e-02 4019 4 4 1.000 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 O15541,P08235,Q8N4J0,Q96B70 174 2.88e-02 4447 4 4 1.000 0.001 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 O15541,P08235,Q8N4J0,Q96B70 174 2.99e-02 4491 4 4 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 O15541,P08235,Q8N4J0,Q96B70 174 3.82e-02 4774 4 4 1.000 0.001 HPA:041020_01 hpa 1 spleen; cells in white pulp[Uncertain,Low] 1 O15541,P08235,Q8N4J0,Q96B70 174 4.15e-02 4872 4 4 1.000 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 O15541,P08235,Q8N4J0,Q96B70 174 4.33e-02 32 4 1 0.250 0.031 REAC:383280 rea 1 Nuclear Receptor transcription pathway 1 P08235 174 4.42e-02 4 4 1 0.250 0.250 TF:M06554_0 tf 1 Factor: ZNF483; motif: KGGTGCTTCCGA; match class: 0 1 O15541 174 5.00e-02 919 4 3 0.750 0.003 TF:M00991_0 tf 1 Factor: Cdx; motif: NAYNRHNARAKTHATAAA; match class: 0 1 O15541,P08235,Q8N4J0 174 5.00e-02 3 4 1 0.250 0.333 CORUM:786 cor 1 MR-UBC9-SRC1 complex 1 P08235 174 5.00e-02 18 4 1 0.250 0.056 KEGG:00340 keg 1 Histidine metabolism 1 Q8N4J0 174 5.00e-02 37 4 1 0.250 0.027 REAC:6788656 rea 1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 1 Q8N4J0 174 5.00e-02 1 4 1 0.250 1.000 HP:0040085 hp 1 Abnormal circulating aldosterone 1 P08235 174 5.00e-02 5 4 1 0.250 0.200 OMIM:601675 omi 1 Trichothiodystrophy 1 O15541 174 5.00e-02 1 4 1 0.250 1.000 HP:0002924 hp 1 Decreased circulating aldosterone level 1 P08235 174 5.00e-02 1 4 1 0.250 1.000 GO:0030735 MF 1 carnosine N-methyltransferase activity 1 Q8N4J0 174 5.00e-02 3 4 1 0.250 0.333 CORUM:3634 cor 1 NR3C2-UBC9-SRC-1 complex 1 P08235 175 7.27e-04 1 2 1 0.500 1.000 GO:1905546 BP 1 cellular response to phenylpropanoid 1 Q3SY77 175 7.27e-04 1 2 1 0.500 1.000 GO:0033594 BP 1 response to hydroxyisoflavone 1 Q3SY77 175 7.27e-04 1 2 1 0.500 1.000 GO:0071412 BP 1 cellular response to genistein 1 Q3SY77 175 7.27e-04 1 2 1 0.500 1.000 GO:0080184 BP 1 response to phenylpropanoid 1 Q3SY77 175 7.27e-04 1 2 1 0.500 1.000 GO:0033595 BP 1 response to genistein 1 Q3SY77 175 7.27e-04 1 2 1 0.500 1.000 GO:0021997 BP 1 neural plate axis specification 1 Q13635 175 7.27e-04 1 2 1 0.500 1.000 GO:0001840 BP 1 neural plate development 1 Q13635 175 7.27e-04 1 2 1 0.500 1.000 GO:0071413 BP 1 cellular response to hydroxyisoflavone 1 Q3SY77 175 1.45e-03 2 2 1 0.500 0.500 GO:0097108 MF 1 hedgehog family protein binding 1 Q13635 175 1.56e-03 3 2 1 0.500 0.333 REAC:5632681 rea 1 Ligand-receptor interactions 1 Q13635 175 1.57e-03 10 2 1 0.500 0.100 TF:M06413_0 tf 1 Factor: ZNF573; motif: NTGGAAGCCATT; match class: 0 1 Q3SY77 175 1.88e-03 245 2 2 1.000 0.008 GO:0071407 BP 1 cellular response to organic cyclic compound 1 Q3SY77,Q13635 175 2.08e-03 4 2 1 0.500 0.250 REAC:5635851 rea 1 GLI proteins bind promoters of Hh responsive genes to promote transcription 1 Q13635 175 2.18e-03 3 2 1 0.500 0.333 GO:0040015 BP 1 negative regulation of multicellular organism growth 1 Q13635 175 2.18e-03 3 2 1 0.500 0.333 GO:0005119 MF 1 smoothened binding 1 Q13635 175 2.18e-03 3 2 1 0.500 0.333 GO:0071397 BP 1 cellular response to cholesterol 1 Q13635 175 2.20e-03 14 2 1 0.500 0.071 TF:M06237_0 tf 1 Factor: ZNF846; motif: NGGGCMWAAATC; match class: 0 1 Q3SY77 175 3.00e-03 309 2 2 1.000 0.006 GO:0014070 BP 1 response to organic cyclic compound 1 Q3SY77,Q13635 175 3.63e-03 5 2 1 0.500 0.200 GO:0036315 BP 1 cellular response to sterol 1 Q13635 175 3.63e-03 5 2 1 0.500 0.200 GO:0060896 BP 1 neural plate pattern specification 1 Q13635 175 3.92e-03 25 2 1 0.500 0.040 TF:M00081_0 tf 1 Factor: Evi-1; motif: DGATADGATWAGATA; match class: 0 1 Q3SY77 175 4.36e-03 6 2 1 0.500 0.167 GO:0021532 BP 1 neural tube patterning 1 Q13635 175 5.81e-03 8 2 1 0.500 0.125 GO:0070723 BP 1 response to cholesterol 1 Q13635 175 6.20e-03 444 2 2 1.000 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 Q3SY77,Q13635 175 6.22e-03 12 2 1 0.500 0.083 REAC:5635838 rea 1 Activation of SMO 1 Q13635 175 7.22e-03 46 2 1 0.500 0.022 TF:M00024_1 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 1 1 Q13635 175 7.26e-03 10 2 1 0.500 0.100 GO:0060037 BP 1 pharyngeal system development 1 Q13635 175 7.26e-03 10 2 1 0.500 0.100 GO:0036314 BP 1 response to sterol 1 Q13635 175 7.99e-03 11 2 1 0.500 0.091 GO:0000578 BP 1 embryonic axis specification 1 Q13635 175 7.99e-03 11 2 1 0.500 0.091 GO:0040014 BP 1 regulation of multicellular organism growth 1 Q13635 175 8.72e-03 12 2 1 0.500 0.083 GO:0010875 BP 1 positive regulation of cholesterol efflux 1 Q13635 175 8.72e-03 12 2 1 0.500 0.083 GO:0035264 BP 1 multicellular organism growth 1 Q13635 175 8.72e-03 12 2 1 0.500 0.083 GO:0045879 BP 1 negative regulation of smoothened signaling pathway 1 Q13635 175 8.94e-03 57 2 1 0.500 0.018 TF:M05702_0 tf 1 Factor: ZNF-20; motif: KGGTACAAATCA; match class: 0 1 Q13635 175 9.06e-03 1028 2 2 1.000 0.002 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 Q3SY77,Q13635 175 9.44e-03 13 2 1 0.500 0.077 GO:0009813 BP 1 flavonoid biosynthetic process 1 Q3SY77 175 9.44e-03 13 2 1 0.500 0.077 GO:0097306 BP 1 cellular response to alcohol 1 Q13635 175 1.02e-02 14 2 1 0.500 0.071 GO:0030332 MF 1 cyclin binding 1 Q13635 175 1.02e-02 14 2 1 0.500 0.071 GO:0032376 BP 1 positive regulation of cholesterol transport 1 Q13635 175 1.02e-02 14 2 1 0.500 0.071 GO:0010874 BP 1 regulation of cholesterol efflux 1 Q13635 175 1.02e-02 14 2 1 0.500 0.071 GO:0032373 BP 1 positive regulation of sterol transport 1 Q13635 175 1.03e-02 66 2 1 0.500 0.015 TF:M04251_0 tf 1 Factor: FOXJ3; motif: GTAAACATAAACA; match class: 0 1 Q3SY77 175 1.08e-02 586 2 2 1.000 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 Q3SY77,Q13635 175 1.09e-02 15 2 1 0.500 0.067 GO:0052696 BP 1 flavonoid glucuronidation 1 Q3SY77 175 1.23e-02 1414 2 2 1.000 0.001 TF:M07067_1 tf 1 Factor: USF1; motif: NNNNGTCACGTGGN; match class: 1 1 Q3SY77,Q13635 175 1.23e-02 17 2 1 0.500 0.059 GO:0072661 BP 1 protein targeting to plasma membrane 1 Q13635 175 1.23e-02 17 2 1 0.500 0.059 GO:0052695 BP 1 cellular glucuronidation 1 Q3SY77 175 1.23e-02 17 2 1 0.500 0.059 GO:0009812 BP 1 flavonoid metabolic process 1 Q3SY77 175 1.23e-02 17 2 1 0.500 0.059 GO:0009880 BP 1 embryonic pattern specification 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0002744 hp 1 Bilateral cleft lip and palate 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0010756 hp 1 Aplasia/Hypoplasia of the premaxilla 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0010649 hp 1 Flat nasal alae 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:3000034 hp 1 Abnormality of cartilage of nasal septum 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0008501 hp 1 Median cleft lip and palate 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0005326 hp 1 Hypoplastic philtrum 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0100336 hp 1 Bilateral cleft lip 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0100337 hp 1 Bilateral cleft palate 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0005273 hp 1 Absent nasal septal cartilage 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0010650 hp 1 Hypoplasia of the premaxilla 1 Q13635 175 1.25e-02 1 2 1 0.500 1.000 HP:0002507 hp 1 Semilobar holoprosencephaly 1 Q13635 175 1.31e-02 18 2 1 0.500 0.056 GO:0045668 BP 1 negative regulation of osteoblast differentiation 1 Q13635 175 1.35e-02 86 2 1 0.500 0.012 TF:M07434_1 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 1 1 Q3SY77 175 1.36e-02 87 2 1 0.500 0.011 TF:M05412_0 tf 1 Factor: ZNF579; motif: NGYGGGGWGGGG; match class: 0 1 Q3SY77 175 1.38e-02 19 2 1 0.500 0.053 GO:1901655 BP 1 cellular response to ketone 1 Q3SY77 175 1.38e-02 19 2 1 0.500 0.053 GO:0008589 BP 1 regulation of smoothened signaling pathway 1 Q13635 175 1.45e-02 20 2 1 0.500 0.050 GO:0061053 BP 1 somite development 1 Q13635 175 1.45e-02 20 2 1 0.500 0.050 GO:0032370 BP 1 positive regulation of lipid transport 1 Q13635 175 1.52e-02 97 2 1 0.500 0.010 TF:M06106_0 tf 1 Factor: ZNF14; motif: KGGWCCATCAGT; match class: 0 1 Q3SY77 175 1.52e-02 1572 2 2 1.000 0.001 TF:M03882_0 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 0 1 Q3SY77,Q13635 175 1.60e-02 22 2 1 0.500 0.045 GO:0019585 BP 1 glucuronate metabolic process 1 Q3SY77 175 1.60e-02 22 2 1 0.500 0.045 GO:0006063 BP 1 uronic acid metabolic process 1 Q3SY77 175 1.67e-02 1 2 1 0.500 1.000 OMIM:610828 omi 1 HOLOPROSENCEPHALY 7; HPE7 1 Q13635 175 1.72e-02 110 2 1 0.500 0.009 TF:M02252_1 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 1 1 Q3SY77 175 1.82e-02 25 2 1 0.500 0.040 GO:0035113 BP 1 embryonic appendage morphogenesis 1 Q13635 175 1.82e-02 25 2 1 0.500 0.040 GO:0030326 BP 1 embryonic limb morphogenesis 1 Q13635 175 1.82e-02 25 2 1 0.500 0.040 GO:0032374 BP 1 regulation of cholesterol transport 1 Q13635 175 1.82e-02 25 2 1 0.500 0.040 GO:0032371 BP 1 regulation of sterol transport 1 Q13635 175 1.92e-02 123 2 1 0.500 0.008 TF:M04181_1 tf 1 Factor: MYF6; motif: AACARCTGTT; match class: 1 1 Q3SY77 175 1.92e-02 123 2 1 0.500 0.008 TF:M04570_0 tf 1 Factor: MSC; motif: AACAGCTGTT; match class: 0 1 Q3SY77 175 1.92e-02 123 2 1 0.500 0.008 TF:M04570_1 tf 1 Factor: MSC; motif: AACAGCTGTT; match class: 1 1 Q3SY77 175 1.92e-02 123 2 1 0.500 0.008 TF:M04181_0 tf 1 Factor: MYF6; motif: AACARCTGTT; match class: 0 1 Q3SY77 175 1.96e-02 27 2 1 0.500 0.037 GO:0009953 BP 1 dorsal/ventral pattern formation 1 Q13635 175 2.02e-02 129 2 1 0.500 0.008 TF:M04107_0 tf 1 Factor: RUNX2; motif: WRACCGCANWAACCGCAN; match class: 0 1 Q13635 175 2.11e-02 29 2 1 0.500 0.034 GO:0060170 CC 1 ciliary membrane 1 Q13635 175 2.11e-02 29 2 1 0.500 0.034 GO:0097305 BP 1 response to alcohol 1 Q13635 175 2.11e-02 29 2 1 0.500 0.034 GO:0030279 BP 1 negative regulation of ossification 1 Q13635 175 2.11e-02 29 2 1 0.500 0.034 GO:0009798 BP 1 axis specification 1 Q13635 175 2.13e-02 1859 2 2 1.000 0.001 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 Q3SY77,Q13635 175 2.14e-02 137 2 1 0.500 0.007 TF:M06701_0 tf 1 Factor: ZNF319; motif: NGGTWAAACCGA; match class: 0 1 Q3SY77 175 2.18e-02 30 2 1 0.500 0.033 GO:0035108 BP 1 limb morphogenesis 1 Q13635 175 2.18e-02 30 2 1 0.500 0.033 GO:0033344 BP 1 cholesterol efflux 1 Q13635 175 2.18e-02 30 2 1 0.500 0.033 GO:0035107 BP 1 appendage morphogenesis 1 Q13635 175 2.22e-02 142 2 1 0.500 0.007 TF:M07048_0 tf 1 Factor: MafG; motif: CMATGACTCAGCAGA; match class: 0 1 Q3SY77 175 2.33e-02 45 2 1 0.500 0.022 REAC:373080 rea 1 Class B/2 (Secretin family receptors) 1 Q13635 175 2.37e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q13635 175 2.37e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q13635 175 2.37e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q13635 175 2.37e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q13635 175 2.40e-02 33 2 1 0.500 0.030 GO:0015485 MF 1 cholesterol binding 1 Q13635 175 2.40e-02 33 2 1 0.500 0.030 GO:1901654 BP 1 response to ketone 1 Q3SY77 175 2.50e-02 2 2 1 0.500 0.500 HP:0100338 hp 1 Non-midline cleft palate 1 Q13635 175 2.50e-02 2 2 1 0.500 0.500 HP:0009099 hp 1 Median cleft palate 1 Q13635 175 2.50e-02 2 2 1 0.500 0.500 HP:0010663 hp 1 Abnormality of thalamus morphology 1 Q13635 175 2.58e-02 165 2 1 0.500 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 Q3SY77 175 2.61e-02 167 2 1 0.500 0.006 TF:M06226_0 tf 1 Factor: ZNF460; motif: KGGGACAGCGGA; match class: 0 1 Q13635 175 2.68e-02 172 2 1 0.500 0.006 TF:M01204_0 tf 1 Factor: Spi-B; motif: AAAAWGMGGAAGTWNSN; match class: 0 1 Q13635 175 2.73e-02 289 2 2 1.000 0.007 MI:hsa-miR-500* mi 1 MI:hsa-miR-500* 1 Q3SY77,Q13635 175 2.76e-02 38 2 1 0.500 0.026 GO:0032934 MF 1 sterol binding 1 Q13635 175 2.76e-02 38 2 1 0.500 0.026 GO:0048640 BP 1 negative regulation of developmental growth 1 Q13635 175 2.83e-02 39 2 1 0.500 0.026 GO:0021915 BP 1 neural tube development 1 Q13635 175 2.83e-02 39 2 1 0.500 0.026 GO:0007224 BP 1 smoothened signaling pathway 1 Q13635 175 2.84e-02 182 2 1 0.500 0.005 TF:M06292_0 tf 1 Factor: ZNF766; motif: NCGTGAAGGAAA; match class: 0 1 Q13635 175 2.90e-02 40 2 1 0.500 0.025 GO:0060173 BP 1 limb development 1 Q13635 175 2.90e-02 40 2 1 0.500 0.025 GO:0048736 BP 1 appendage development 1 Q13635 175 2.94e-02 2181 2 2 1.000 0.001 TF:M03890_0 tf 1 Factor: TFEA; motif: GYCASVTGACYN; match class: 0 1 Q3SY77,Q13635 175 3.05e-02 42 2 1 0.500 0.024 GO:0005901 CC 1 caveola 1 Q13635 175 3.12e-02 43 2 1 0.500 0.023 GO:0032368 BP 1 regulation of lipid transport 1 Q13635 175 3.26e-02 45 2 1 0.500 0.022 GO:0045667 BP 1 regulation of osteoblast differentiation 1 Q13635 175 3.35e-02 2330 2 2 1.000 0.001 TF:M07141_0 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 0 1 Q3SY77,Q13635 175 3.41e-02 47 2 1 0.500 0.021 GO:0044853 CC 1 plasma membrane raft 1 Q13635 175 3.41e-02 47 2 1 0.500 0.021 GO:0043178 MF 1 alcohol binding 1 Q13635 175 3.55e-02 49 2 1 0.500 0.020 GO:0030301 BP 1 cholesterol transport 1 Q13635 175 3.70e-02 51 2 1 0.500 0.020 GO:0015918 BP 1 sterol transport 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0005449 hp 1 Bridged sella turcica 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0010603 hp 1 Odontogenic keratocysts of the jaw 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0001144 hp 1 Orbital cyst 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0004795 hp 1 Hamartomatous stomach polyps 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0009650 hp 1 Short distal phalanx of the thumb 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0004280 hp 1 Irregular ossification of hand bones 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0009641 hp 1 Aplasia/Hypoplasia of the distal phalanx of the thumb 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0010617 hp 1 Cardiac fibroma 1 Q13635 175 3.75e-02 3 2 1 0.500 0.333 HP:0010618 hp 1 Ovarian fibroma 1 Q13635 175 3.78e-02 243 2 1 0.500 0.004 TF:M00641_0 tf 1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 0 1 Q13635 175 3.79e-02 2478 2 2 1.000 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q3SY77,Q13635 175 3.84e-02 53 2 1 0.500 0.019 GO:0005496 MF 1 steroid binding 1 Q13635 175 3.86e-02 2500 2 2 1.000 0.001 TF:M01209_0 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 0 1 Q3SY77,Q13635 175 3.87e-02 75 2 1 0.500 0.013 REAC:5632684 rea 1 Hedgehog 'on' state 1 Q13635 175 3.87e-02 249 2 1 0.500 0.004 TF:M04110_0 tf 1 Factor: RUNX3; motif: NRACCGCANWAACCRCAN; match class: 0 1 Q13635 175 3.91e-02 251 2 1 0.500 0.004 TF:M03899_1 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 1 1 Q13635 175 4.01e-02 2548 2 2 1.000 0.001 TF:M00106_0 tf 1 Factor: CDP; motif: NATYGATSSS; match class: 0 1 Q3SY77,Q13635 175 4.01e-02 258 2 1 0.500 0.004 TF:M06275_0 tf 1 Factor: ZNF284; motif: NGGGGGTGGTGM; match class: 0 1 Q3SY77 175 4.03e-02 259 2 1 0.500 0.004 TF:M07350_1 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 1 1 Q3SY77 175 4.11e-02 264 2 1 0.500 0.004 TF:M00415_1 tf 1 Factor: AREB6; motif: CBGTTTSNN; match class: 1 1 Q3SY77 175 4.14e-02 266 2 1 0.500 0.004 TF:M04196_0 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 0 1 Q13635 175 4.14e-02 266 2 1 0.500 0.004 TF:M04196_1 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 1 1 Q13635 175 4.21e-02 1157 2 2 1.000 0.002 GO:0071310 BP 1 cellular response to organic substance 1 Q3SY77,Q13635 175 4.46e-02 2689 2 2 1.000 0.001 TF:M06190_1 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 1 1 Q3SY77,Q13635 175 4.46e-02 2689 2 2 1.000 0.001 TF:M06191_1 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 1 1 Q3SY77,Q13635 175 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q13635 175 4.77e-02 307 2 1 0.500 0.003 TF:M06527_0 tf 1 Factor: ZNF675; motif: TGAAAGGGGA; match class: 0 1 Q13635 175 4.78e-02 66 2 1 0.500 0.015 GO:0098876 BP 1 vesicle-mediated transport to the plasma membrane 1 Q13635 175 4.83e-02 2797 2 2 1.000 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q3SY77,Q13635 175 4.85e-02 2804 2 2 1.000 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 Q3SY77,Q13635 175 5.00e-02 391 2 2 1.000 0.005 MI:hsa-miR-758 mi 1 MI:hsa-miR-758 1 Q3SY77,Q13635 175 5.00e-02 97 2 1 0.500 0.010 REAC:5610787 rea 1 Hedgehog 'off' state 1 Q13635 175 5.00e-02 3 2 1 0.500 0.333 OMIM:605462 omi 1 BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1; BCC1BASAL CELL CARCINOMA, NONSYNDROMIC, INCLUDED;;BASAL CELL CARCINOMA, MULTIPLE, INCLUDED 1 Q13635 175 5.00e-02 3 2 1 0.500 0.333 CORUM:5551 cor 1 CDC2-CCNB1-PTCH1 complex 1 Q13635 175 5.00e-02 37 2 1 0.500 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q13635 175 5.00e-02 69 2 1 0.500 0.014 GO:0030278 BP 1 regulation of ossification 1 Q13635 175 5.00e-02 37 2 1 0.500 0.027 KEGG:05217 keg 1 Basal cell carcinoma 1 Q13635 175 5.00e-02 4 2 1 0.500 0.250 HP:0010758 hp 1 Abnormality of the premaxilla 1 Q13635 175 5.00e-02 3 2 1 0.500 0.333 OMIM:109400 omi 1 BASAL CELL NEVUS SYNDROME; BCNS;;GORLIN SYNDROME;;GORLIN-GOLTZ SYNDROME;;NEVOID BASAL CELL CARCINOMA SYNDROME; NBCCS;;MULTIPLE BASAL CELL NEVI, ODONTOGENIC KERATOCYSTS, AND SKELETAL ANOMALIES 1 Q13635 175 5.00e-02 4 2 1 0.500 0.250 HP:0010610 hp 1 Palmar pits 1 Q13635 175 5.00e-02 4 2 1 0.500 0.250 HP:0010612 hp 1 Plantar pits 1 Q13635 175 5.00e-02 4 2 1 0.500 0.250 HP:0009935 hp 1 Aplasia/Hypoplasia of the nasal septum 1 Q13635 175 5.00e-02 3 2 1 0.500 0.333 OMIM:236100 omi 1 Holoprosencephaly 1 Q13635 176 1.34e-07 12 7 3 0.429 0.250 GO:0008484 MF 1 sulfuric ester hydrolase activity 1 P15289,P34059,Q6UWY0 176 2.14e-06 127 7 4 0.571 0.031 GO:0005788 CC 1 endoplasmic reticulum lumen 1 Q9P2K2,P15289,Q8NBL1,Q6UWY0 176 3.95e-05 8 7 2 0.286 0.250 GO:0004065 MF 1 arylsulfatase activity 1 P15289,Q6UWY0 176 5.12e-05 81 7 3 0.429 0.037 GO:0006664 BP 1 glycolipid metabolic process 1 P15289,Q8NBL1,Q6UWY0 176 5.51e-05 83 7 3 0.429 0.036 GO:1903509 BP 1 liposaccharide metabolic process 1 P15289,Q8NBL1,Q6UWY0 176 2.37e-04 135 7 3 0.429 0.022 GO:0006643 BP 1 membrane lipid metabolic process 1 P15289,Q8NBL1,Q6UWY0 176 2.49e-04 9 7 2 0.286 0.222 REAC:1663150 rea 1 The activation of arylsulfatases 1 P15289,Q6UWY0 176 5.08e-04 504 7 4 0.571 0.008 GO:0016788 MF 1 hydrolase activity, acting on ester bonds 1 P15289,Q9HAT2,P34059,Q6UWY0 176 8.33e-04 35 7 2 0.286 0.057 GO:0043687 BP 1 post-translational protein modification 1 P15289,Q6UWY0 176 1.43e-03 658 7 4 0.571 0.006 GO:0044432 CC 1 endoplasmic reticulum part 1 Q9P2K2,P15289,Q8NBL1,Q6UWY0 176 1.85e-03 52 7 2 0.286 0.038 GO:0006687 BP 1 glycosphingolipid metabolic process 1 P15289,Q6UWY0 176 2.72e-03 1 7 1 0.143 1.000 GO:0034338 MF 1 short-chain carboxylesterase activity 1 Q9HAT2 176 2.72e-03 1 7 1 0.143 1.000 GO:0008126 MF 1 acetylesterase activity 1 Q9HAT2 176 2.72e-03 1 7 1 0.143 1.000 GO:0001681 MF 1 sialate O-acetylesterase activity 1 Q9HAT2 176 2.72e-03 1 7 1 0.143 1.000 GO:0004098 MF 1 cerebroside-sulfatase activity 1 P15289 176 2.78e-03 29 7 2 0.286 0.069 REAC:163841 rea 1 Gamma carboxylation, hypusine formation and arylsulfatase activation 1 P15289,Q6UWY0 176 3.01e-03 798 7 4 0.571 0.005 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P15289,P34059,Q8NBL1,Q6UWY0 176 3.54e-03 72 7 2 0.286 0.028 GO:0005775 CC 1 vacuolar lumen 1 P15289,P34059 176 3.54e-03 72 7 2 0.286 0.028 GO:0043202 CC 1 lysosomal lumen 1 P15289,P34059 176 4.30e-03 567 7 3 0.429 0.005 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P15289,Q9HAT2,P34059 176 5.05e-03 39 7 2 0.286 0.051 REAC:1660662 rea 1 Glycosphingolipid metabolism 1 P15289,Q6UWY0 176 5.43e-03 2 7 1 0.143 0.500 GO:0003943 MF 1 N-acetylgalactosamine-4-sulfatase activity 1 P34059 176 5.46e-03 933 7 4 0.571 0.004 GO:0005783 CC 1 endoplasmic reticulum 1 Q9P2K2,P15289,Q8NBL1,Q6UWY0 176 7.21e-03 103 7 2 0.286 0.019 GO:0006665 BP 1 sphingolipid metabolic process 1 P15289,Q6UWY0 176 8.34e-03 1462 7 4 0.571 0.003 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 Q9P2K2,P15289,Q9HAT2,P34059 176 9.85e-03 761 7 3 0.429 0.004 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P15289,Q9HAT2,P34059 176 1.41e-02 867 7 3 0.429 0.003 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q9P2K2,P15289,P34059 176 1.65e-02 2194 7 5 0.714 0.002 GO:0070062 CC 1 extracellular exosome 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 1.69e-02 2205 7 5 0.714 0.002 GO:1903561 CC 1 extracellular vesicle 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 1.69e-02 2205 7 5 0.714 0.002 GO:0043230 CC 1 extracellular organelle 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 1.72e-02 72 7 2 0.286 0.028 REAC:428157 rea 1 Sphingolipid metabolism 1 P15289,Q6UWY0 176 2.17e-02 8 7 1 0.143 0.125 GO:0035252 MF 1 UDP-xylosyltransferase activity 1 Q8NBL1 176 2.17e-02 8 7 1 0.143 0.125 GO:0042285 MF 1 xylosyltransferase activity 1 Q8NBL1 176 2.18e-02 633 7 3 0.429 0.005 GO:0044255 BP 1 cellular lipid metabolic process 1 P15289,Q8NBL1,Q6UWY0 176 2.25e-02 375 7 2 0.286 0.005 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P15289,P34059 176 2.44e-02 9 7 1 0.143 0.111 GO:0035251 MF 1 UDP-glucosyltransferase activity 1 Q8NBL1 176 2.50e-02 1 7 1 0.143 1.000 HP:0005609 hp 1 Gallbladder dysfunction 1 P15289 176 2.50e-02 1 7 1 0.143 1.000 HP:0012070 hp 1 Chondroitin sulfate excretion in urine 1 P34059 176 2.61e-02 111 7 2 0.286 0.018 KEGG:04142 keg 1 Lysosome 1 P15289,P34059 176 2.71e-02 10 7 1 0.143 0.100 GO:0042340 BP 1 keratan sulfate catabolic process 1 P34059 176 2.74e-02 416 7 2 0.286 0.005 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 P15289,P34059 176 3.21e-02 6607 7 7 1.000 0.001 HPA:002010_02 hpa 1 appendix; glandular cells[Uncertain,Medium] 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1,Q6UWY0,Q5T4B2 176 3.38e-02 363 7 2 0.286 0.006 MI:hsa-miR-150* mi 1 MI:hsa-miR-150* 1 Q8NBL1,Q5T4B2 176 3.40e-02 2173 7 4 0.571 0.002 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q9P2K2,P15289,P34059,Q6UWY0 176 3.52e-02 13 7 1 0.143 0.077 GO:0045747 BP 1 positive regulation of Notch signaling pathway 1 Q8NBL1 176 3.72e-02 765 7 3 0.429 0.004 GO:0006629 BP 1 lipid metabolic process 1 P15289,Q8NBL1,Q6UWY0 176 3.78e-02 2627 7 5 0.714 0.002 GO:0044421 CC 1 extracellular region part 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 3.79e-02 14 7 1 0.143 0.071 GO:0046527 MF 1 glucosyltransferase activity 1 Q8NBL1 176 3.95e-02 394 7 2 0.286 0.005 MI:hsa-miR-523 mi 1 MI:hsa-miR-523 1 Q9HAT2,P34059 176 3.98e-02 1274 7 3 0.429 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P15289,Q9HAT2,P34059 176 4.14e-02 1607 7 4 0.571 0.002 GO:0016787 MF 1 hydrolase activity 1 P15289,Q9HAT2,P34059,Q6UWY0 176 4.29e-02 412 7 2 0.286 0.005 MI:hsa-miR-889 mi 1 MI:hsa-miR-889 1 Q9P2K2,Q6UWY0 176 4.59e-02 2743 7 5 0.714 0.002 GO:0005576 CC 1 extracellular region 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 4.72e-02 2392 7 4 0.571 0.002 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q9P2K2,P15289,P34059,Q6UWY0 176 4.79e-02 437 7 2 0.286 0.005 MI:hsa-miR-217 mi 1 MI:hsa-miR-217 1 Q9P2K2,Q9HAT2 176 5.00e-02 2 7 1 0.143 0.500 HP:0012069 hp 1 Keratan sulfate excretion in urine 1 P34059 176 5.00e-02 1 7 1 0.143 1.000 OMIM:613551 omi 1 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6; AIS6 1 Q9HAT2 176 5.00e-02 1 7 1 0.143 1.000 OMIM:615696 omi 1 DOWLING-DEGOS DISEASE 4; DDD4 1 Q8NBL1 176 5.00e-02 2 7 1 0.143 0.500 HP:0007133 hp 1 Progressive peripheral neuropathy 1 P15289 176 5.00e-02 2795 7 5 0.714 0.002 GO:0031982 CC 1 vesicle 1 Q9P2K2,P15289,Q9HAT2,P34059,Q8NBL1 176 5.00e-02 13 7 1 0.143 0.077 KEGG:00531 keg 1 Glycosaminoglycan degradation 1 P34059 176 5.00e-02 1 7 1 0.143 1.000 OMIM:250100 omi 1 METACHROMATIC LEUKODYSTROPHY;;MLD;;METACHROMATIC LEUKOENCEPHALOPATHY;;CEREBRAL SCLEROSIS, DIFFUSE, METACHROMATIC FORM;;SULFATIDE LIPIDOSIS;;ARYLSULFATASE A DEFICIENCY;;ARSA DEFICIENCY;;CEREBROSIDE SULFATASE DEFICIENCYPSEUDOARYLSULFATASE A DEFICIENCY, INCLUDED;;METACHROMATIC LEUKODYSTROPHY, LATE INFANTILE, INCLUDED;;METACHROMATIC LEUKODYSTROPHY, JUVENILE, INCLUDED;;METACHROMATIC LEUKODYSTROPHY, ADULT, INCLUDED 1 P15289 176 5.00e-02 2 7 1 0.143 0.500 HP:0003277 hp 1 Constricted iliac wings 1 P34059 176 5.00e-02 325 7 3 0.429 0.009 TF:M07422_0 tf 1 Factor: MASH-1; motif: CCWBMCACCTGCC; match class: 0 1 Q9P2K2,P15289,P34059 176 5.00e-02 1 7 1 0.143 1.000 OMIM:253000 omi 1 MUCOPOLYSACCHARIDOSIS, TYPE IVA; MPS4A;;MORQUIO SYNDROME A;;MPS IVA;;MORQUIO A DISEASE;;GALACTOSAMINE-6-SULFATASE DEFICIENCY;;GALNS DEFICIENCY 1 P34059 176 5.00e-02 2 7 1 0.143 0.500 HP:0001223 hp 1 Pointed proximal second through fifth metacarpals 1 P34059 176 5.00e-02 447 7 2 0.286 0.004 MI:hsa-miR-872 mi 1 MI:hsa-miR-872 1 Q9P2K2,Q9HAT2 176 5.00e-02 4 7 1 0.143 0.250 CORUM:1379 cor 1 GALNS-lysosomal hydrolase 1.27 MDa complex 1 P34059 176 5.00e-02 2 7 1 0.143 0.500 HP:0000683 hp 1 Grayish enamel 1 P34059 176 5.00e-02 6 7 1 0.143 0.167 REAC:1912399 rea 1 Pre-NOTCH Processing in the Endoplasmic Reticulum 1 Q8NBL1 177 2.05e-04 45 3 2 0.667 0.044 GO:0031338 BP 1 regulation of vesicle fusion 1 Q0IIM8,Q66K14 177 3.19e-04 56 3 2 0.667 0.036 GO:0090630 BP 1 activation of GTPase activity 1 Q0IIM8,Q66K14 177 8.46e-04 91 3 2 0.667 0.022 GO:0017137 MF 1 Rab GTPase binding 1 Q0IIM8,Q66K14 177 1.19e-03 108 3 2 0.667 0.019 GO:0006906 BP 1 vesicle fusion 1 Q0IIM8,Q66K14 177 1.21e-03 109 3 2 0.667 0.018 GO:0090174 BP 1 organelle membrane fusion 1 Q0IIM8,Q66K14 177 1.26e-03 111 3 2 0.667 0.018 GO:0043547 BP 1 positive regulation of GTPase activity 1 Q0IIM8,Q66K14 177 1.78e-03 132 3 2 0.667 0.015 GO:0044801 BP 1 single-organism membrane fusion 1 Q0IIM8,Q66K14 177 2.18e-03 146 3 2 0.667 0.014 GO:0048284 BP 1 organelle fusion 1 Q0IIM8,Q66K14 177 2.33e-03 151 3 2 0.667 0.013 GO:0043087 BP 1 regulation of GTPase activity 1 Q0IIM8,Q66K14 177 2.52e-03 157 3 2 0.667 0.013 GO:0061025 BP 1 membrane fusion 1 Q0IIM8,Q66K14 177 2.85e-03 167 3 2 0.667 0.012 GO:0005096 MF 1 GTPase activator activity 1 Q0IIM8,Q66K14 177 2.92e-03 169 3 2 0.667 0.012 GO:0017016 MF 1 Ras GTPase binding 1 Q0IIM8,Q66K14 177 3.46e-03 184 3 2 0.667 0.011 GO:0031267 MF 1 small GTPase binding 1 Q0IIM8,Q66K14 177 3.88e-03 195 3 2 0.667 0.010 GO:0030695 MF 1 GTPase regulator activity 1 Q0IIM8,Q66K14 177 4.13e-03 201 3 2 0.667 0.010 GO:0051020 MF 1 GTPase binding 1 Q0IIM8,Q66K14 177 5.03e-03 222 3 2 0.667 0.009 GO:0060589 MF 1 nucleoside-triphosphatase regulator activity 1 Q0IIM8,Q66K14 177 5.81e-03 501 3 2 0.667 0.004 MI:hsa-miR-196a mi 1 MI:hsa-miR-196a 1 Q0IIM8,Q53H82 177 8.04e-03 281 3 2 0.667 0.007 GO:0016050 BP 1 vesicle organization 1 Q0IIM8,Q66K14 177 8.27e-03 285 3 2 0.667 0.007 GO:0060627 BP 1 regulation of vesicle-mediated transport 1 Q0IIM8,Q66K14 177 8.68e-03 292 3 2 0.667 0.007 GO:0051345 BP 1 positive regulation of hydrolase activity 1 Q0IIM8,Q66K14 177 8.97e-03 297 3 2 0.667 0.007 GO:0008047 MF 1 enzyme activator activity 1 Q0IIM8,Q66K14 177 1.01e-02 664 3 2 0.667 0.003 MI:mmu-miR-466f-3p mi 1 MI:mmu-miR-466f-3p 1 Q0IIM8,Q53H82 177 1.91e-02 16 3 1 0.333 0.062 GO:0090502 BP 1 RNA phosphodiester bond hydrolysis, endonucleolytic 1 Q53H82 177 2.58e-02 506 3 2 0.667 0.004 GO:0051336 BP 1 regulation of hydrolase activity 1 Q0IIM8,Q66K14 177 3.39e-02 582 3 2 0.667 0.003 GO:0030234 MF 1 enzyme regulator activity 1 Q0IIM8,Q66K14 177 3.90e-02 56 3 1 0.333 0.018 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 Q0IIM8 177 3.97e-02 630 3 2 0.667 0.003 GO:0044802 BP 1 single-organism membrane organization 1 Q0IIM8,Q66K14 177 4.27e-02 217 3 2 0.667 0.009 TF:M00141_1 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 1 1 Q0IIM8,Q53H82 177 4.42e-02 37 3 1 0.333 0.027 GO:0004521 MF 1 endoribonuclease activity 1 Q53H82 177 4.49e-02 671 3 2 0.667 0.003 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q0IIM8,Q66K14 177 4.97e-02 707 3 2 0.667 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q0IIM8,Q66K14 177 5.00e-02 72 3 1 0.333 0.014 REAC:421837 rea 1 Clathrin derived vesicle budding 1 Q0IIM8 177 5.00e-02 72 3 1 0.333 0.014 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 Q0IIM8 177 5.00e-02 709 3 2 0.667 0.003 GO:0006886 BP 1 intracellular protein transport 1 Q0IIM8,Q66K14 177 5.00e-02 235 3 2 0.667 0.009 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 Q0IIM8,Q66K14 178 2.56e-08 2 2 2 1.000 1.000 GO:1904928 MF 1 coreceptor activity involved in canonical Wnt signaling pathway 1 O75581,O75197 178 7.69e-08 3 2 2 1.000 0.667 GO:1990851 CC 1 Wnt-Frizzled-LRP5/6 complex 1 O75581,O75197 178 7.69e-08 3 2 2 1.000 0.667 GO:0019534 MF 1 toxin transporter activity 1 O75581,O75197 178 1.54e-07 4 2 2 1.000 0.500 GO:0044332 BP 1 Wnt signaling pathway involved in dorsal/ventral axis specification 1 O75581,O75197 178 4.03e-07 5 2 2 1.000 0.400 REAC:5340588 rea 1 RNF mutants show enhanced WNT signaling and proliferation 1 O75581,O75197 178 5.38e-07 7 2 2 1.000 0.286 GO:0071936 MF 1 coreceptor activity involved in Wnt signaling pathway 1 O75581,O75197 178 9.22e-07 9 2 2 1.000 0.222 GO:1990909 CC 1 Wnt signalosome 1 O75581,O75197 178 1.15e-06 10 2 2 1.000 0.200 GO:0009950 BP 1 dorsal/ventral axis specification 1 O75581,O75197 178 1.15e-06 10 2 2 1.000 0.200 GO:0060042 BP 1 retina morphogenesis in camera-type eye 1 O75581,O75197 178 1.82e-06 10 2 2 1.000 0.200 REAC:3772470 rea 1 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1 O75581,O75197 178 2.69e-06 15 2 2 1.000 0.133 GO:0042813 MF 1 Wnt-activated receptor activity 1 O75581,O75197 178 3.92e-06 18 2 2 1.000 0.111 GO:0017147 MF 1 Wnt-protein binding 1 O75581,O75197 178 4.24e-06 15 2 2 1.000 0.133 REAC:4641263 rea 1 Regulation of FZD by ubiquitination 1 O75581,O75197 178 4.38e-06 19 2 2 1.000 0.105 GO:0015026 MF 1 coreceptor activity 1 O75581,O75197 178 4.87e-06 20 2 2 1.000 0.100 GO:1904886 BP 1 beta-catenin destruction complex disassembly 1 O75581,O75197 178 8.99e-06 27 2 2 1.000 0.074 GO:0009953 BP 1 dorsal/ventral pattern formation 1 O75581,O75197 178 8.99e-06 27 2 2 1.000 0.074 GO:0048593 BP 1 camera-type eye morphogenesis 1 O75581,O75197 178 1.04e-05 29 2 2 1.000 0.069 GO:0009798 BP 1 axis specification 1 O75581,O75197 178 1.11e-05 30 2 2 1.000 0.067 GO:0060041 BP 1 retina development in camera-type eye 1 O75581,O75197 178 1.42e-05 27 2 2 1.000 0.074 REAC:4791275 rea 1 Signaling by WNT in cancer 1 O75581,O75197 178 1.64e-05 29 2 2 1.000 0.069 REAC:4641262 rea 1 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 O75581,O75197 178 2.10e-05 41 2 2 1.000 0.049 GO:0048592 BP 1 eye morphogenesis 1 O75581,O75197 178 4.24e-05 58 2 2 1.000 0.034 GO:0090596 BP 1 sensory organ morphogenesis 1 O75581,O75197 178 4.54e-05 60 2 2 1.000 0.033 GO:0043010 BP 1 camera-type eye development 1 O75581,O75197 178 5.17e-05 64 2 2 1.000 0.031 GO:0061448 BP 1 connective tissue development 1 O75581,O75197 178 6.19e-05 70 2 2 1.000 0.029 GO:0071901 BP 1 negative regulation of protein serine/threonine kinase activity 1 O75581,O75197 178 6.73e-05 73 2 2 1.000 0.027 GO:0003002 BP 1 regionalization 1 O75581,O75197 178 1.05e-04 91 2 2 1.000 0.022 GO:0001654 BP 1 eye development 1 O75581,O75197 178 1.71e-04 116 2 2 1.000 0.017 GO:0007423 BP 1 sensory organ development 1 O75581,O75197 178 1.74e-04 117 2 2 1.000 0.017 GO:0007389 BP 1 pattern specification process 1 O75581,O75197 178 1.99e-04 125 2 2 1.000 0.016 GO:0098797 CC 1 plasma membrane protein complex 1 O75581,O75197 178 2.25e-04 133 2 2 1.000 0.015 GO:0006469 BP 1 negative regulation of protein kinase activity 1 O75581,O75197 178 2.60e-04 143 2 2 1.000 0.014 GO:0033673 BP 1 negative regulation of kinase activity 1 O75581,O75197 178 2.94e-04 152 2 2 1.000 0.013 GO:0001501 BP 1 skeletal system development 1 O75581,O75197 178 2.96e-04 1 2 1 0.500 1.000 GO:2000055 BP 1 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification 1 O75581 178 2.96e-04 1 2 1 0.500 1.000 GO:0034392 BP 1 negative regulation of smooth muscle cell apoptotic process 1 O75581 178 3.34e-04 162 2 2 1.000 0.012 GO:0060828 BP 1 regulation of canonical Wnt signaling pathway 1 O75581,O75197 178 4.36e-04 185 2 2 1.000 0.011 GO:0043241 BP 1 protein complex disassembly 1 O75581,O75197 178 4.65e-04 191 2 2 1.000 0.010 GO:0060070 BP 1 canonical Wnt signaling pathway 1 O75581,O75197 178 4.90e-04 196 2 2 1.000 0.010 GO:0043235 CC 1 receptor complex 1 O75581,O75197 178 5.46e-04 165 2 2 1.000 0.012 REAC:201681 rea 1 TCF dependent signaling in response to WNT 1 O75581,O75197 178 5.57e-04 209 2 2 1.000 0.010 GO:0032984 BP 1 macromolecular complex disassembly 1 O75581,O75197 178 5.62e-04 210 2 2 1.000 0.010 GO:0030111 BP 1 regulation of Wnt signaling pathway 1 O75581,O75197 178 5.89e-04 215 2 2 1.000 0.009 GO:0045787 BP 1 positive regulation of cell cycle 1 O75581,O75197 178 5.91e-04 2 2 1 0.500 0.500 GO:0030917 BP 1 midbrain-hindbrain boundary development 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0035112 BP 1 genitalia morphogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0061304 BP 1 retinal blood vessel morphogenesis 1 O75197 178 5.91e-04 2 2 1 0.500 0.500 GO:0060534 BP 1 trachea cartilage development 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0060059 BP 1 embryonic retina morphogenesis in camera-type eye 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0090245 BP 1 axis elongation involved in somitogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0090118 BP 1 receptor-mediated endocytosis involved in cholesterol transport 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0060535 BP 1 trachea cartilage morphogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:2000053 BP 1 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0060439 BP 1 trachea morphogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0044335 BP 1 canonical Wnt signaling pathway involved in neural crest cell differentiation 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0060536 BP 1 cartilage morphogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0035261 BP 1 external genitalia morphogenesis 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0090009 BP 1 primitive streak formation 1 O75581 178 5.91e-04 2 2 1 0.500 0.500 GO:0048539 BP 1 bone marrow development 1 O75197 178 6.29e-04 222 2 2 1.000 0.009 GO:0001933 BP 1 negative regulation of protein phosphorylation 1 O75581,O75197 178 6.81e-04 231 2 2 1.000 0.009 GO:0051348 BP 1 negative regulation of transferase activity 1 O75581,O75197 178 7.72e-04 246 2 2 1.000 0.008 GO:0042326 BP 1 negative regulation of phosphorylation 1 O75581,O75197 178 8.74e-04 3 2 1 0.500 0.333 REAC:5339717 rea 1 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 1 O75197 178 8.87e-04 3 2 1 0.500 0.333 GO:0021903 BP 1 rostrocaudal neural tube patterning 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0034391 BP 1 regulation of smooth muscle cell apoptotic process 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0001702 BP 1 gastrulation with mouth forming second 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0061299 BP 1 retina vasculature morphogenesis in camera-type eye 1 O75197 178 8.87e-04 3 2 1 0.500 0.333 GO:0014029 BP 1 neural crest formation 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0060438 BP 1 trachea development 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0034390 BP 1 smooth muscle cell apoptotic process 1 O75581 178 8.87e-04 3 2 1 0.500 0.333 GO:0071397 BP 1 cellular response to cholesterol 1 O75581 178 9.72e-04 276 2 2 1.000 0.007 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 O75581,O75197 178 1.16e-03 301 2 2 1.000 0.007 GO:0198738 BP 1 cell-cell signaling by wnt 1 O75581,O75197 178 1.16e-03 301 2 2 1.000 0.007 GO:0016055 BP 1 Wnt signaling pathway 1 O75581,O75197 178 1.18e-03 4 2 1 0.500 0.250 GO:0021794 BP 1 thalamus development 1 O75581 178 1.18e-03 4 2 1 0.500 0.250 GO:0060026 BP 1 convergent extension 1 O75581 178 1.23e-03 247 2 2 1.000 0.008 REAC:195721 rea 1 Signaling by Wnt 1 O75581,O75197 178 1.32e-03 322 2 2 1.000 0.006 GO:0045936 BP 1 negative regulation of phosphate metabolic process 1 O75581,O75197 178 1.33e-03 323 2 2 1.000 0.006 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 O75581,O75197 178 1.33e-03 323 2 2 1.000 0.006 GO:0010563 BP 1 negative regulation of phosphorus metabolic process 1 O75581,O75197 178 1.48e-03 5 2 1 0.500 0.200 GO:0090244 BP 1 Wnt signaling pathway involved in somitogenesis 1 O75581 178 1.48e-03 5 2 1 0.500 0.200 GO:0044340 BP 1 canonical Wnt signaling pathway involved in regulation of cell proliferation 1 O75581 178 1.48e-03 5 2 1 0.500 0.200 GO:0010656 BP 1 negative regulation of muscle cell apoptotic process 1 O75581 178 1.48e-03 5 2 1 0.500 0.200 GO:0036315 BP 1 cellular response to sterol 1 O75581 178 1.55e-03 348 2 2 1.000 0.006 GO:0009887 BP 1 animal organ morphogenesis 1 O75581,O75197 178 1.75e-03 370 2 2 1.000 0.005 GO:0031400 BP 1 negative regulation of protein modification process 1 O75581,O75197 178 1.77e-03 372 2 2 1.000 0.005 GO:0072359 BP 1 circulatory system development 1 O75581,O75197 178 1.77e-03 6 2 1 0.500 0.167 GO:0021532 BP 1 neural tube patterning 1 O75581 178 1.77e-03 6 2 1 0.500 0.167 GO:0003344 BP 1 pericardium morphogenesis 1 O75581 178 1.77e-03 6 2 1 0.500 0.167 GO:0002076 BP 1 osteoblast development 1 O75197 178 1.92e-03 309 2 2 1.000 0.006 REAC:5663202 rea 1 Diseases of signal transduction 1 O75581,O75197 178 2.07e-03 402 2 2 1.000 0.005 GO:0045859 BP 1 regulation of protein kinase activity 1 O75581,O75197 178 2.07e-03 7 2 1 0.500 0.143 GO:0021587 BP 1 cerebellum morphogenesis 1 O75581 178 2.07e-03 7 2 1 0.500 0.143 GO:0060039 BP 1 pericardium development 1 O75581 178 2.24e-03 419 2 2 1.000 0.005 GO:0043086 BP 1 negative regulation of catalytic activity 1 O75581,O75197 178 2.32e-03 426 2 2 1.000 0.005 GO:0022411 BP 1 cellular component disassembly 1 O75581,O75197 178 2.36e-03 8 2 1 0.500 0.125 GO:0021575 BP 1 hindbrain morphogenesis 1 O75581 178 2.36e-03 8 2 1 0.500 0.125 GO:0070723 BP 1 response to cholesterol 1 O75581 178 2.36e-03 8 2 1 0.500 0.125 GO:0061298 BP 1 retina vasculature development in camera-type eye 1 O75197 178 2.36e-03 8 2 1 0.500 0.125 GO:0003401 BP 1 axis elongation 1 O75581 178 2.36e-03 8 2 1 0.500 0.125 GO:0005041 MF 1 low-density lipoprotein receptor activity 1 O75581 178 2.46e-03 439 2 2 1.000 0.005 GO:0043549 BP 1 regulation of kinase activity 1 O75581,O75197 178 2.52e-03 444 2 2 1.000 0.005 GO:0098796 CC 1 membrane protein complex 1 O75581,O75197 178 2.52e-03 444 2 2 1.000 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 O75581,O75197 178 2.57e-03 448 2 2 1.000 0.004 GO:0004888 MF 1 transmembrane signaling receptor activity 1 O75581,O75197 178 2.66e-03 9 2 1 0.500 0.111 GO:0034185 MF 1 apolipoprotein binding 1 O75581 178 2.66e-03 9 2 1 0.500 0.111 GO:0060612 BP 1 adipose tissue development 1 O75197 178 2.66e-03 9 2 1 0.500 0.111 GO:0002053 BP 1 positive regulation of mesenchymal cell proliferation 1 O75197 178 2.93e-03 479 2 2 1.000 0.004 GO:0099600 MF 1 transmembrane receptor activity 1 O75581,O75197 178 2.95e-03 10 2 1 0.500 0.100 GO:0032367 BP 1 intracellular cholesterol transport 1 O75581 178 2.95e-03 10 2 1 0.500 0.100 GO:0030228 MF 1 lipoprotein particle receptor activity 1 O75581 178 2.95e-03 10 2 1 0.500 0.100 GO:0036314 BP 1 response to sterol 1 O75581 178 3.13e-03 495 2 2 1.000 0.004 GO:0038023 MF 1 signaling receptor activity 1 O75581,O75197 178 3.21e-03 501 2 2 1.000 0.004 GO:0051094 BP 1 positive regulation of developmental process 1 O75581,O75197 178 3.25e-03 11 2 1 0.500 0.091 GO:0001756 BP 1 somitogenesis 1 O75581 178 3.25e-03 11 2 1 0.500 0.091 GO:1904953 BP 1 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1 O75581 178 3.25e-03 11 2 1 0.500 0.091 GO:0032366 BP 1 intracellular sterol transport 1 O75581 178 3.40e-03 516 2 2 1.000 0.004 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 O75581,O75197 178 3.54e-03 12 2 1 0.500 0.083 GO:0010660 BP 1 regulation of muscle cell apoptotic process 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:0048806 BP 1 genitalia development 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:0010464 BP 1 regulation of mesenchymal cell proliferation 1 O75197 178 3.54e-03 12 2 1 0.500 0.083 GO:0060325 BP 1 face morphogenesis 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:1904948 BP 1 midbrain dopaminergic neuron differentiation 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:0010657 BP 1 muscle cell apoptotic process 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:0022037 BP 1 metencephalon development 1 O75581 178 3.54e-03 12 2 1 0.500 0.083 GO:0021549 BP 1 cerebellum development 1 O75581 178 3.84e-03 13 2 1 0.500 0.077 GO:0021536 BP 1 diencephalon development 1 O75581 178 3.84e-03 13 2 1 0.500 0.077 GO:0097306 BP 1 cellular response to alcohol 1 O75581 178 3.84e-03 13 2 1 0.500 0.077 GO:0060323 BP 1 head morphogenesis 1 O75581 178 4.14e-03 14 2 1 0.500 0.071 GO:0061178 BP 1 regulation of insulin secretion involved in cellular response to glucose stimulus 1 O75197 178 4.14e-03 14 2 1 0.500 0.071 GO:0009948 BP 1 anterior/posterior axis specification 1 O75581 178 4.14e-03 14 2 1 0.500 0.071 GO:0010463 BP 1 mesenchymal cell proliferation 1 O75197 178 4.16e-03 570 2 2 1.000 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 O75581,O75197 178 4.18e-03 572 2 2 1.000 0.003 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 O75581,O75197 178 4.26e-03 577 2 2 1.000 0.003 GO:0051338 BP 1 regulation of transferase activity 1 O75581,O75197 178 4.39e-03 586 2 2 1.000 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 O75581,O75197 178 4.43e-03 15 2 1 0.500 0.067 GO:0042475 BP 1 odontogenesis of dentin-containing tooth 1 O75581 178 4.43e-03 15 2 1 0.500 0.067 GO:0060324 BP 1 face development 1 O75581 178 4.71e-03 607 2 2 1.000 0.003 GO:0051248 BP 1 negative regulation of protein metabolic process 1 O75581,O75197 178 4.74e-03 609 2 2 1.000 0.003 GO:0004872 MF 1 receptor activity 1 O75581,O75197 178 4.74e-03 609 2 2 1.000 0.003 GO:0060089 MF 1 molecular transducer activity 1 O75581,O75197 178 5.02e-03 17 2 1 0.500 0.059 GO:0060349 BP 1 bone morphogenesis 1 O75197 178 5.02e-03 17 2 1 0.500 0.059 GO:0009880 BP 1 embryonic pattern specification 1 O75581 178 5.32e-03 18 2 1 0.500 0.056 GO:0045668 BP 1 negative regulation of osteoblast differentiation 1 O75197 178 5.61e-03 19 2 1 0.500 0.053 GO:0035773 BP 1 insulin secretion involved in cellular response to glucose stimulus 1 O75197 178 5.78e-03 672 2 2 1.000 0.003 GO:0042127 BP 1 regulation of cell proliferation 1 O75581,O75197 178 5.90e-03 679 2 2 1.000 0.003 GO:0051726 BP 1 regulation of cell cycle 1 O75581,O75197 178 5.91e-03 20 2 1 0.500 0.050 GO:0035282 BP 1 segmentation 1 O75581 178 5.91e-03 20 2 1 0.500 0.050 GO:0061053 BP 1 somite development 1 O75581 178 5.91e-03 20 2 1 0.500 0.050 GO:0071542 BP 1 dopaminergic neuron differentiation 1 O75581 178 5.91e-03 20 2 1 0.500 0.050 GO:0045600 BP 1 positive regulation of fat cell differentiation 1 O75197 178 5.91e-03 20 2 1 0.500 0.050 GO:0038024 MF 1 cargo receptor activity 1 O75581 178 6.20e-03 21 2 1 0.500 0.048 GO:0010171 BP 1 body morphogenesis 1 O75581 178 6.20e-03 21 2 1 0.500 0.048 GO:0005109 MF 1 frizzled binding 1 O75581 178 6.27e-03 700 2 2 1.000 0.003 GO:0001932 BP 1 regulation of protein phosphorylation 1 O75581,O75197 178 6.50e-03 22 2 1 0.500 0.045 GO:0030902 BP 1 hindbrain development 1 O75581 178 6.50e-03 22 2 1 0.500 0.045 GO:0032365 BP 1 intracellular lipid transport 1 O75581 178 6.65e-03 721 2 2 1.000 0.003 GO:0004871 MF 1 signal transducer activity 1 O75581,O75197 178 6.79e-03 23 2 1 0.500 0.043 GO:0060021 BP 1 palate development 1 O75581 178 7.03e-03 741 2 2 1.000 0.003 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 O75581,O75197 178 7.03e-03 741 2 2 1.000 0.003 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 O75581,O75197 178 7.20e-03 750 2 2 1.000 0.003 GO:0005215 MF 1 transporter activity 1 O75581,O75197 178 7.22e-03 751 2 2 1.000 0.003 GO:0009888 BP 1 tissue development 1 O75581,O75197 178 7.27e-03 754 2 2 1.000 0.003 GO:0007267 BP 1 cell-cell signaling 1 O75581,O75197 178 7.38e-03 25 2 1 0.500 0.040 GO:0045840 BP 1 positive regulation of mitotic nuclear division 1 O75197 178 7.39e-03 760 2 2 1.000 0.003 GO:0042325 BP 1 regulation of phosphorylation 1 O75581,O75197 178 7.43e-03 762 2 2 1.000 0.003 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 O75581,O75197 178 8.01e-03 791 2 2 1.000 0.003 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 O75581,O75197 178 8.27e-03 28 2 1 0.500 0.036 GO:0001843 BP 1 neural tube closure 1 O75581 178 8.27e-03 28 2 1 0.500 0.036 GO:0060606 BP 1 tube closure 1 O75581 178 8.27e-03 28 2 1 0.500 0.036 GO:0006007 BP 1 glucose catabolic process 1 O75197 178 8.34e-03 1 2 1 0.500 1.000 HP:0007958 hp 1 Optic atrophy from cranial nerve compression 1 O75197 178 8.34e-03 1 2 1 0.500 1.000 HP:0008037 hp 1 Absent anterior eye chamber 1 O75197 178 8.34e-03 1 2 1 0.500 1.000 HP:0008114 hp 1 Metatarsal diaphyseal endosteal sclerosis 1 O75197 178 8.34e-03 1 2 1 0.500 1.000 HP:0100861 hp 1 Vertebral body sclerosis 1 O75197 178 8.34e-03 1 2 1 0.500 1.000 HP:0006174 hp 1 Metacarpal diaphyseal endosteal sclerosis 1 O75197 178 8.56e-03 29 2 1 0.500 0.034 GO:0030279 BP 1 negative regulation of ossification 1 O75197 178 8.56e-03 29 2 1 0.500 0.034 GO:0042476 BP 1 odontogenesis 1 O75581 178 8.56e-03 29 2 1 0.500 0.034 GO:0051785 BP 1 positive regulation of nuclear division 1 O75197 178 8.56e-03 29 2 1 0.500 0.034 GO:0001841 BP 1 neural tube formation 1 O75581 178 8.56e-03 29 2 1 0.500 0.034 GO:0014020 BP 1 primary neural tube formation 1 O75581 178 8.56e-03 29 2 1 0.500 0.034 GO:0097305 BP 1 response to alcohol 1 O75581 178 8.86e-03 30 2 1 0.500 0.033 GO:0021987 BP 1 cerebral cortex development 1 O75581 178 8.86e-03 30 2 1 0.500 0.033 GO:0002011 BP 1 morphogenesis of an epithelial sheet 1 O75581 178 9.09e-03 77 2 2 1.000 0.026 HP:0011001 hp 1 Increased bone mineral density 1 O75581,O75197 178 9.15e-03 31 2 1 0.500 0.032 GO:0071333 BP 1 cellular response to glucose stimulus 1 O75197 178 9.74e-03 33 2 1 0.500 0.030 GO:0001838 BP 1 embryonic epithelial tube formation 1 O75581 178 9.74e-03 33 2 1 0.500 0.030 GO:0071326 BP 1 cellular response to monosaccharide stimulus 1 O75197 178 9.74e-03 33 2 1 0.500 0.030 GO:0071331 BP 1 cellular response to hexose stimulus 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:610947 omi 1 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2 1 O75581 178 1.00e-02 1 2 1 0.500 1.000 OMIM:607636 omi 1 VAN BUCHEM DISEASE, TYPE 2;;VBCH2 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:601813 omi 1 EXUDATIVE VITREORETINOPATHY 4; EVR4 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:144750 omi 1 ENDOSTEAL HYPEROSTOSIS, AUTOSOMAL DOMINANT;;HYPEROSTOSIS CORTICALIS GENERALISATA, BENIGN FORM OF WORTH, WITH TORUSPALATINUS;;OSTEOSCLEROSIS, AUTOSOMAL DOMINANT 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:601884 omi 1 BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1; BMND1HIGH BONE MASS, INCLUDED; HBM, INCLUDED;;OSTEOPOROSIS, SUSCEPTIBILITY TO, INCLUDED 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:259770 omi 1 OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME; OPPG;;OPS;;OSTEOGENESIS IMPERFECTA, OCULAR FORM 1 O75197 178 1.00e-02 1 2 1 0.500 1.000 OMIM:607634 omi 1 Autosomal Dominant Osteopetrosis 1 O75197 178 1.00e-02 885 2 2 1.000 0.002 GO:0019220 BP 1 regulation of phosphate metabolic process 1 O75581,O75197 178 1.00e-02 34 2 1 0.500 0.029 GO:0072175 BP 1 epithelial tube formation 1 O75581 178 1.00e-02 34 2 1 0.500 0.029 GO:0014033 BP 1 neural crest cell differentiation 1 O75581 178 1.03e-02 896 2 2 1.000 0.002 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 O75581,O75197 178 1.03e-02 897 2 2 1.000 0.002 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 O75581,O75197 178 1.03e-02 35 2 1 0.500 0.029 GO:0042632 BP 1 cholesterol homeostasis 1 O75197 178 1.03e-02 35 2 1 0.500 0.029 GO:0055092 BP 1 sterol homeostasis 1 O75197 178 1.03e-02 35 2 1 0.500 0.029 GO:0071322 BP 1 cellular response to carbohydrate stimulus 1 O75197 178 1.04e-02 720 2 2 1.000 0.003 REAC:1643685 rea 1 Disease 1 O75581,O75197 178 1.05e-02 906 2 2 1.000 0.002 GO:0008283 BP 1 cell proliferation 1 O75581,O75197 178 1.09e-02 922 2 2 1.000 0.002 GO:0010628 BP 1 positive regulation of gene expression 1 O75581,O75197 178 1.09e-02 37 2 1 0.500 0.027 GO:0060541 BP 1 respiratory system development 1 O75581 178 1.09e-02 37 2 1 0.500 0.027 GO:0009952 BP 1 anterior/posterior pattern specification 1 O75581 178 1.09e-02 37 2 1 0.500 0.027 GO:0021543 BP 1 pallium development 1 O75581 178 1.11e-02 933 2 2 1.000 0.002 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 O75581,O75197 178 1.12e-02 38 2 1 0.500 0.026 GO:0016331 BP 1 morphogenesis of embryonic epithelium 1 O75581 178 1.15e-02 39 2 1 0.500 0.026 GO:0021915 BP 1 neural tube development 1 O75581 178 1.17e-02 956 2 2 1.000 0.002 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 O75581,O75197 178 1.18e-02 40 2 1 0.500 0.025 GO:0035148 BP 1 tube formation 1 O75581 178 1.20e-02 967 2 2 1.000 0.002 GO:0031399 BP 1 regulation of protein modification process 1 O75581,O75197 178 1.20e-02 970 2 2 1.000 0.002 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 O75581,O75197 178 1.21e-02 971 2 2 1.000 0.002 GO:0009891 BP 1 positive regulation of biosynthetic process 1 O75581,O75197 178 1.24e-02 42 2 1 0.500 0.024 GO:0048705 BP 1 skeletal system morphogenesis 1 O75197 178 1.24e-02 42 2 1 0.500 0.024 GO:0060348 BP 1 bone development 1 O75197 178 1.24e-02 42 2 1 0.500 0.024 GO:0005901 CC 1 caveola 1 O75581 178 1.26e-02 993 2 2 1.000 0.002 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 O75581,O75197 178 1.27e-02 43 2 1 0.500 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 O75197 178 1.30e-02 44 2 1 0.500 0.023 GO:0019320 BP 1 hexose catabolic process 1 O75197 178 1.32e-02 1015 2 2 1.000 0.002 GO:0071822 BP 1 protein complex subunit organization 1 O75581,O75197 178 1.33e-02 45 2 1 0.500 0.022 GO:0031901 CC 1 early endosome membrane 1 O75581 178 1.33e-02 45 2 1 0.500 0.022 GO:0045667 BP 1 regulation of osteoblast differentiation 1 O75197 178 1.36e-02 46 2 1 0.500 0.022 GO:0045598 BP 1 regulation of fat cell differentiation 1 O75197 178 1.39e-02 47 2 1 0.500 0.021 GO:0044853 CC 1 plasma membrane raft 1 O75581 178 1.42e-02 48 2 1 0.500 0.021 GO:0051216 BP 1 cartilage development 1 O75581 178 1.45e-02 49 2 1 0.500 0.020 GO:0030301 BP 1 cholesterol transport 1 O75581 178 1.46e-02 1067 2 2 1.000 0.002 GO:0050793 BP 1 regulation of developmental process 1 O75581,O75197 178 1.46e-02 1068 2 2 1.000 0.002 GO:0006468 BP 1 protein phosphorylation 1 O75581,O75197 178 1.47e-02 1071 2 2 1.000 0.002 GO:0050790 BP 1 regulation of catalytic activity 1 O75581,O75197 178 1.47e-02 50 2 1 0.500 0.020 GO:0009749 BP 1 response to glucose 1 O75197 178 1.50e-02 51 2 1 0.500 0.020 GO:0021953 BP 1 central nervous system neuron differentiation 1 O75581 178 1.50e-02 51 2 1 0.500 0.020 GO:0015918 BP 1 sterol transport 1 O75581 178 1.50e-02 51 2 1 0.500 0.020 GO:0030901 BP 1 midbrain development 1 O75581 178 1.53e-02 52 2 1 0.500 0.019 GO:0046365 BP 1 monosaccharide catabolic process 1 O75197 178 1.56e-02 53 2 1 0.500 0.019 GO:0034284 BP 1 response to monosaccharide 1 O75197 178 1.56e-02 53 2 1 0.500 0.019 GO:0009746 BP 1 response to hexose 1 O75197 178 1.57e-02 1107 2 2 1.000 0.002 GO:0009653 BP 1 anatomical structure morphogenesis 1 O75581,O75197 178 1.59e-02 1113 2 2 1.000 0.002 GO:0048513 BP 1 animal organ development 1 O75581,O75197 178 1.62e-02 55 2 1 0.500 0.018 GO:0008217 BP 1 regulation of blood pressure 1 O75197 178 1.63e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 O75581,O75197 178 1.65e-02 56 2 1 0.500 0.018 GO:0009743 BP 1 response to carbohydrate 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0007989 hp 1 Intraretinal exudate 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0001089 hp 1 Iris atrophy 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0100925 hp 1 Sclerosis of foot bone 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0007685 hp 1 Peripheral retinal avascularization 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0011958 hp 1 Retinal perforation 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0001489 hp 1 Posterior vitreous detachment 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0007710 hp 1 Peripheral vitreous opacities 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0100923 hp 1 Clavicular sclerosis 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0011530 hp 1 Retinal hole 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0001493 hp 1 Falciform retinal fold 1 O75197 178 1.67e-02 2 2 1 0.500 0.500 HP:0011532 hp 1 Subretinal exudate 1 O75197 178 1.71e-02 1157 2 2 1.000 0.002 GO:0071310 BP 1 cellular response to organic substance 1 O75581,O75197 178 1.77e-02 60 2 1 0.500 0.017 GO:0021537 BP 1 telencephalon development 1 O75581 178 1.77e-02 60 2 1 0.500 0.017 GO:0007548 BP 1 sex differentiation 1 O75581 178 1.77e-02 1177 2 2 1.000 0.002 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 O75581,O75197 178 1.86e-02 63 2 1 0.500 0.016 GO:0019210 MF 1 kinase inhibitor activity 1 O75581 178 2.00e-02 2 2 1 0.500 0.500 OMIM:133780 omi 1 Familial Exudative Vitreoretinopathy 1 O75197 178 2.03e-02 69 2 1 0.500 0.014 GO:0030278 BP 1 regulation of ossification 1 O75197 178 2.03e-02 69 2 1 0.500 0.014 GO:0055088 BP 1 lipid homeostasis 1 O75197 178 2.03e-02 69 2 1 0.500 0.014 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 O75197 178 2.04e-02 1263 2 2 1.000 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 O75581,O75197 178 2.05e-02 1266 2 2 1.000 0.002 GO:0016310 BP 1 phosphorylation 1 O75581,O75197 178 2.06e-02 70 2 1 0.500 0.014 GO:0048863 BP 1 stem cell differentiation 1 O75581 178 2.07e-02 1272 2 2 1.000 0.002 GO:0044459 CC 1 plasma membrane part 1 O75581,O75197 178 2.09e-02 71 2 1 0.500 0.014 GO:0007369 BP 1 gastrulation 1 O75581 178 2.09e-02 71 2 1 0.500 0.014 GO:0050796 BP 1 regulation of insulin secretion 1 O75197 178 2.18e-02 74 2 1 0.500 0.014 GO:0001837 BP 1 epithelial to mesenchymal transition 1 O75581 178 2.20e-02 1310 2 2 1.000 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 O75581,O75197 178 2.22e-02 1317 2 2 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 O75581,O75197 178 2.31e-02 1342 2 2 1.000 0.001 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 O75581,O75197 178 2.36e-02 80 2 1 0.500 0.013 GO:0042593 BP 1 glucose homeostasis 1 O75197 178 2.36e-02 80 2 1 0.500 0.013 GO:0033500 BP 1 carbohydrate homeostasis 1 O75197 178 2.36e-02 80 2 1 0.500 0.013 GO:0090276 BP 1 regulation of peptide hormone secretion 1 O75197 178 2.39e-02 81 2 1 0.500 0.012 GO:0002791 BP 1 regulation of peptide secretion 1 O75197 178 2.41e-02 82 2 1 0.500 0.012 GO:0045444 BP 1 fat cell differentiation 1 O75197 178 2.41e-02 82 2 1 0.500 0.012 GO:0061458 BP 1 reproductive system development 1 O75581 178 2.41e-02 82 2 1 0.500 0.012 GO:0048608 BP 1 reproductive structure development 1 O75581 178 2.43e-02 1377 2 2 1.000 0.001 GO:0071702 BP 1 organic substance transport 1 O75581,O75197 178 2.44e-02 83 2 1 0.500 0.012 GO:0090087 BP 1 regulation of peptide transport 1 O75197 178 2.47e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 O75581,O75197 178 2.47e-02 84 2 1 0.500 0.012 GO:0030073 BP 1 insulin secretion 1 O75197 178 2.48e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 O75581,O75197 178 2.49e-02 1394 2 2 1.000 0.001 GO:0010033 BP 1 response to organic substance 1 O75581,O75197 178 2.50e-02 3 2 1 0.500 0.333 HP:0030490 hp 1 Exudative vitreoretinopathy 1 O75197 178 2.50e-02 3 2 1 0.500 0.333 HP:0007917 hp 1 Tractional retinal detachment 1 O75197 178 2.50e-02 3 2 1 0.500 0.333 HP:0012052 hp 1 Low serum calcitriol 1 O75197 178 2.56e-02 87 2 1 0.500 0.011 GO:0030900 BP 1 forebrain development 1 O75581 178 2.57e-02 1416 2 2 1.000 0.001 GO:0007166 BP 1 cell surface receptor signaling pathway 1 O75581,O75197 178 2.59e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 O75581,O75197 178 2.60e-02 1424 2 2 1.000 0.001 GO:0009892 BP 1 negative regulation of metabolic process 1 O75581,O75197 178 2.65e-02 90 2 1 0.500 0.011 GO:0090263 BP 1 positive regulation of canonical Wnt signaling pathway 1 O75581 178 2.66e-02 1442 2 2 1.000 0.001 GO:0051246 BP 1 regulation of protein metabolic process 1 O75581,O75197 178 2.71e-02 92 2 1 0.500 0.011 GO:0043025 CC 1 neuronal cell body 1 O75581 178 2.83e-02 96 2 1 0.500 0.010 GO:0030072 BP 1 peptide hormone secretion 1 O75197 178 2.85e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 O75581,O75197 178 2.85e-02 97 2 1 0.500 0.010 GO:0046883 BP 1 regulation of hormone secretion 1 O75197 178 2.85e-02 97 2 1 0.500 0.010 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 O75197 178 2.85e-02 97 2 1 0.500 0.010 GO:0002790 BP 1 peptide secretion 1 O75197 178 2.87e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 O75581,O75197 178 2.88e-02 98 2 1 0.500 0.010 GO:0001664 MF 1 G-protein coupled receptor binding 1 O75581 178 2.88e-02 98 2 1 0.500 0.010 GO:0060560 BP 1 developmental growth involved in morphogenesis 1 O75581 178 2.88e-02 98 2 1 0.500 0.010 GO:0001649 BP 1 osteoblast differentiation 1 O75197 178 2.91e-02 99 2 1 0.500 0.010 GO:0060562 BP 1 epithelial tube morphogenesis 1 O75581 178 2.94e-02 100 2 1 0.500 0.010 GO:0015850 BP 1 organic hydroxy compound transport 1 O75581 178 2.97e-02 101 2 1 0.500 0.010 GO:0007088 BP 1 regulation of mitotic nuclear division 1 O75197 178 2.97e-02 1524 2 2 1.000 0.001 GO:0030154 BP 1 cell differentiation 1 O75581,O75197 178 3.00e-02 102 2 1 0.500 0.010 GO:0016052 BP 1 carbohydrate catabolic process 1 O75197 178 3.02e-02 8 2 1 0.500 0.125 TF:M01890_1 tf 1 Factor: STAT5A; motif: NNNTTTCTNRGAA; match class: 1 1 O75581 178 3.06e-02 104 2 1 0.500 0.010 GO:0044297 CC 1 cell body 1 O75581 178 3.12e-02 106 2 1 0.500 0.009 GO:0015833 BP 1 peptide transport 1 O75197 178 3.15e-02 107 2 1 0.500 0.009 GO:0051783 BP 1 regulation of nuclear division 1 O75197 178 3.17e-02 1573 2 2 1.000 0.001 GO:0009966 BP 1 regulation of signal transduction 1 O75581,O75197 178 3.18e-02 108 2 1 0.500 0.009 GO:0048762 BP 1 mesenchymal cell differentiation 1 O75581 178 3.21e-02 109 2 1 0.500 0.009 GO:0043009 BP 1 chordate embryonic development 1 O75581 178 3.21e-02 109 2 1 0.500 0.009 GO:0035239 BP 1 tube morphogenesis 1 O75581 178 3.21e-02 109 2 1 0.500 0.009 GO:0009792 BP 1 embryo development ending in birth or egg hatching 1 O75581 178 3.24e-02 110 2 1 0.500 0.009 GO:0006006 BP 1 glucose metabolic process 1 O75197 178 3.32e-02 113 2 1 0.500 0.009 GO:0046879 BP 1 hormone secretion 1 O75197 178 3.33e-02 4 2 1 0.500 0.250 HP:0000667 hp 1 Phthisis bulbi 1 O75197 178 3.33e-02 4 2 1 0.500 0.250 HP:0008052 hp 1 Retinal fold 1 O75197 178 3.33e-02 4 2 1 0.500 0.250 HP:0100511 hp 1 Abnormality of vitamin D metabolism 1 O75197 178 3.33e-02 4 2 1 0.500 0.250 HP:0005789 hp 1 Generalized osteosclerosis 1 O75197 178 3.34e-02 1614 2 2 1.000 0.001 GO:0043933 BP 1 macromolecular complex subunit organization 1 O75581,O75197 178 3.35e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 O75581,O75197 178 3.38e-02 115 2 1 0.500 0.009 GO:0030177 BP 1 positive regulation of Wnt signaling pathway 1 O75581 178 3.41e-02 480 2 2 1.000 0.004 TF:M01890_0 tf 1 Factor: STAT5A; motif: NNNTTTCTNRGAA; match class: 0 1 O75581,O75197 178 3.42e-02 1635 2 2 1.000 0.001 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 O75581,O75197 178 3.44e-02 117 2 1 0.500 0.009 GO:0009914 BP 1 hormone transport 1 O75197 178 3.44e-02 117 2 1 0.500 0.009 GO:0042886 BP 1 amide transport 1 O75197 178 3.46e-02 1644 2 2 1.000 0.001 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 O75581,O75197 178 3.47e-02 118 2 1 0.500 0.008 GO:0090090 BP 1 negative regulation of canonical Wnt signaling pathway 1 O75581 178 3.48e-02 1649 2 2 1.000 0.001 GO:0048869 BP 1 cellular developmental process 1 O75581,O75197 178 3.49e-02 112 2 2 1.000 0.018 KEGG:05224 keg 1 Breast cancer 1 O75581,O75197 178 3.49e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 O75581,O75197 178 3.51e-02 1656 2 2 1.000 0.001 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 O75581,O75197 178 3.54e-02 1663 2 2 1.000 0.001 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 O75581,O75197 178 3.62e-02 123 2 1 0.500 0.008 GO:0045121 CC 1 membrane raft 1 O75581 178 3.62e-02 1681 2 2 1.000 0.001 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 O75581,O75197 178 3.65e-02 124 2 1 0.500 0.008 GO:0019207 MF 1 kinase regulator activity 1 O75581 178 3.65e-02 124 2 1 0.500 0.008 GO:0098857 CC 1 membrane microdomain 1 O75581 178 3.66e-02 1691 2 2 1.000 0.001 GO:0010646 BP 1 regulation of cell communication 1 O75581,O75197 178 3.70e-02 126 2 1 0.500 0.008 GO:0060485 BP 1 mesenchyme development 1 O75581 178 3.82e-02 1728 2 2 1.000 0.001 GO:0023051 BP 1 regulation of signaling 1 O75581,O75197 178 3.90e-02 1745 2 2 1.000 0.001 GO:0009893 BP 1 positive regulation of metabolic process 1 O75581,O75197 178 3.94e-02 119 2 2 1.000 0.017 KEGG:04310 keg 1 Wnt signaling pathway 1 O75581,O75197 178 4.03e-02 137 2 1 0.500 0.007 GO:0019318 BP 1 hexose metabolic process 1 O75197 178 4.03e-02 137 2 1 0.500 0.007 GO:0030178 BP 1 negative regulation of Wnt signaling pathway 1 O75581 178 4.03e-02 1775 2 2 1.000 0.001 GO:0051252 BP 1 regulation of RNA metabolic process 1 O75581,O75197 178 4.17e-02 5 2 1 0.500 0.200 HP:0007902 hp 1 Vitreous hemorrhage 1 O75197 178 4.17e-02 142 2 1 0.500 0.007 GO:0072659 BP 1 protein localization to plasma membrane 1 O75581 178 4.20e-02 1810 2 2 1.000 0.001 GO:0048731 BP 1 system development 1 O75581,O75197 178 4.20e-02 143 2 1 0.500 0.007 GO:0006869 BP 1 lipid transport 1 O75581 178 4.29e-02 146 2 1 0.500 0.007 GO:0006898 BP 1 receptor-mediated endocytosis 1 O75581 178 4.32e-02 1836 2 2 1.000 0.001 GO:0051641 BP 1 cellular localization 1 O75581,O75197 178 4.39e-02 1851 2 2 1.000 0.001 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 O75581,O75197 178 4.40e-02 150 2 1 0.500 0.007 GO:0001503 BP 1 ossification 1 O75197 178 4.40e-02 150 2 1 0.500 0.007 GO:0003006 BP 1 developmental process involved in reproduction 1 O75581 178 4.45e-02 1865 2 2 1.000 0.001 GO:0006351 BP 1 transcription, DNA-templated 1 O75581,O75197 178 4.46e-02 152 2 1 0.500 0.007 GO:1990778 BP 1 protein localization to cell periphery 1 O75581 178 4.49e-02 1872 2 2 1.000 0.001 GO:0097659 BP 1 nucleic acid-templated transcription 1 O75581,O75197 178 4.49e-02 153 2 1 0.500 0.007 GO:0051091 BP 1 positive regulation of sequence-specific DNA binding transcription factor activity 1 O75581 178 4.54e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 O75581,O75197 178 4.55e-02 155 2 1 0.500 0.006 GO:0098589 CC 1 membrane region 1 O75581 178 4.55e-02 155 2 1 0.500 0.006 GO:0035295 BP 1 tube development 1 O75581 178 4.70e-02 160 2 1 0.500 0.006 GO:0090068 BP 1 positive regulation of cell cycle process 1 O75197 178 4.74e-02 1923 2 2 1.000 0.001 GO:0006793 BP 1 phosphorus metabolic process 1 O75581,O75197 178 4.74e-02 1923 2 2 1.000 0.001 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 O75581,O75197 178 4.81e-02 164 2 1 0.500 0.006 GO:0010876 BP 1 lipid localization 1 O75581 178 4.84e-02 165 2 1 0.500 0.006 GO:0005769 CC 1 early endosome 1 O75581 178 4.93e-02 168 2 1 0.500 0.006 GO:0048589 BP 1 developmental growth 1 O75581 178 4.99e-02 170 2 1 0.500 0.006 GO:0005996 BP 1 monosaccharide metabolic process 1 O75197 178 4.99e-02 170 2 1 0.500 0.006 GO:0050708 BP 1 regulation of protein secretion 1 O75197 178 5.00e-02 6 2 1 0.500 0.167 HP:0000935 hp 1 Thickened cortex of long bones 1 O75197 178 5.00e-02 581 2 2 1.000 0.003 TF:M01666_0 tf 1 Factor: STAT4; motif: TTCMNAGAADHNMA; match class: 0 1 O75581,O75197 178 5.00e-02 134 2 2 1.000 0.015 KEGG:04150 keg 1 mTOR signaling pathway 1 O75581,O75197 178 5.00e-02 6 2 1 0.500 0.167 HP:0004425 hp 1 Flat forehead 1 O75197 178 5.00e-02 1976 2 2 1.000 0.001 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 O75581,O75197 178 5.00e-02 6 2 1 0.500 0.167 HP:0100039 hp 1 Thickened cortex of bones 1 O75197 178 5.00e-02 6 2 1 0.500 0.167 HP:0001147 hp 1 Retinal exudate 1 O75197 178 5.00e-02 6 2 1 0.500 0.167 HP:0100789 hp 1 Torus palatinus 1 O75197 178 5.00e-02 1575 2 2 1.000 0.001 REAC:162582 rea 1 Signal Transduction 1 O75581,O75197 178 5.00e-02 5 2 1 0.500 0.200 OMIM:166710 omi 1 OSTEOPOROSIS;;BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS; BMND;;OSTEOPOROSIS, POSTMENOPAUSAL;;OSTEOPOROSIS, INVOLUTIONALFRACTURE, HIP, SUSCEPTIBILITY TO, INCLUDED 1 O75197 179 1.06e-06 3 4 2 0.500 0.667 GO:0032299 CC 1 ribonuclease H2 complex 1 O75792,Q5TBB1 179 1.27e-04 7 4 2 0.500 0.286 HP:0009709 hp 1 Increased CSF interferon alpha 1 O75792,Q5TBB1 179 1.27e-04 7 4 2 0.500 0.286 HP:0007321 hp 1 Deep white matter hypodensities 1 O75792,Q5TBB1 179 1.27e-04 7 4 2 0.500 0.286 HP:0009710 hp 1 Chilblain lesions 1 O75792,Q5TBB1 179 1.27e-04 7 4 2 0.500 0.286 HP:0009704 hp 1 Chronic CSF lymphocytosis 1 O75792,Q5TBB1 179 1.27e-04 7 4 2 0.500 0.286 HP:0200149 hp 1 CSF lymphocytic pleiocytosis 1 O75792,Q5TBB1 179 2.18e-04 9 4 2 0.500 0.222 HP:0002448 hp 1 Progressive encephalopathy 1 O75792,Q5TBB1 179 2.18e-04 9 4 2 0.500 0.222 HP:0012229 hp 1 CSF pleocytosis 1 O75792,Q5TBB1 179 3.33e-04 11 4 2 0.500 0.182 HP:0004394 hp 1 Multiple gastric polyps 1 O75792,Q5TBB1 179 3.33e-04 11 4 2 0.500 0.182 HP:0002461 hp 1 Dense calcifications in the cerebellar dentate nucleus 1 O75792,Q5TBB1 179 3.33e-04 11 4 2 0.500 0.182 HP:0002504 hp 1 Calcification of the small brain vessels 1 O75792,Q5TBB1 179 4.00e-04 12 4 2 0.500 0.167 HP:0001047 hp 1 Atopic dermatitis 1 O75792,Q5TBB1 179 4.00e-04 12 4 2 0.500 0.167 HP:0007103 hp 1 Hypointensity of cerebral white matter on MRI 1 O75792,Q5TBB1 179 6.35e-04 15 4 2 0.500 0.133 HP:0007352 hp 1 Cerebellar calcifications 1 O75792,Q5TBB1 179 8.21e-04 17 4 2 0.500 0.118 HP:0100321 hp 1 Abnormality of the dentate nucleus 1 O75792,Q5TBB1 179 1.03e-03 19 4 2 0.500 0.105 HP:0004934 hp 1 Vascular calcification 1 O75792,Q5TBB1 179 1.08e-03 6 4 2 0.500 0.333 OMIM:225750 omi 1 Aicardi-Goutieres Syndrome 1 O75792,Q5TBB1 179 1.15e-03 20 4 2 0.500 0.100 HP:0011915 hp 1 Cardiovascular calcification 1 O75792,Q5TBB1 179 1.27e-03 21 4 2 0.500 0.095 HP:0000967 hp 1 Petechiae 1 O75792,Q5TBB1 179 1.27e-03 21 4 2 0.500 0.095 HP:0002132 hp 1 Porencephaly 1 O75792,Q5TBB1 179 1.36e-03 1 4 1 0.250 1.000 GO:0097309 BP 1 cap1 mRNA methylation 1 Q8N1G2 179 1.52e-03 23 4 2 0.500 0.087 HP:0000625 hp 1 Cleft eyelid 1 O75792,Q5TBB1 179 1.52e-03 23 4 2 0.500 0.087 HP:0002371 hp 1 Loss of speech 1 O75792,Q5TBB1 179 2.11e-03 27 4 2 0.500 0.074 HP:0002135 hp 1 Basal ganglia calcification 1 O75792,Q5TBB1 179 2.44e-03 29 4 2 0.500 0.069 HP:0006579 hp 1 Prolonged neonatal jaundice 1 O75792,Q5TBB1 179 2.72e-03 2 4 1 0.250 0.500 GO:0004483 MF 1 mRNA (nucleoside-2'-O-)-methyltransferase activity 1 Q8N1G2 179 2.72e-03 2 4 1 0.250 0.500 GO:0036451 BP 1 cap mRNA methylation 1 Q8N1G2 179 2.79e-03 31 4 2 0.500 0.065 HP:0000979 hp 1 Purpura 1 O75792,Q5TBB1 179 2.97e-03 32 4 2 0.500 0.062 HP:0002445 hp 1 Tetraplegia 1 O75792,Q5TBB1 179 3.16e-03 33 4 2 0.500 0.061 HP:0001063 hp 1 Acrocyanosis 1 O75792,Q5TBB1 179 3.98e-03 37 4 2 0.500 0.054 HP:0006957 hp 1 Loss of ability to walk 1 O75792,Q5TBB1 179 4.20e-03 38 4 2 0.500 0.053 HP:0002421 hp 1 Poor head control 1 O75792,Q5TBB1 179 4.89e-03 41 4 2 0.500 0.049 HP:0001433 hp 1 Hepatosplenomegaly 1 O75792,Q5TBB1 179 5.14e-03 42 4 2 0.500 0.048 HP:0002505 hp 1 Progressive inability to walk 1 O75792,Q5TBB1 179 5.43e-03 4 4 1 0.250 0.250 GO:0043137 BP 1 DNA replication, removal of RNA primer 1 O75792 179 5.64e-03 44 4 2 0.500 0.045 HP:0002633 hp 1 Vasculitis 1 O75792,Q5TBB1 179 5.64e-03 44 4 2 0.500 0.045 HP:0001357 hp 1 Plagiocephaly 1 O75792,Q5TBB1 179 6.16e-03 46 4 2 0.500 0.043 HP:0010702 hp 1 Increased antibody level in blood 1 O75792,Q5TBB1 179 6.43e-03 47 4 2 0.500 0.043 HP:0000961 hp 1 Cyanosis 1 O75792,Q5TBB1 179 6.71e-03 48 4 2 0.500 0.042 HP:0030182 hp 1 Tetraplegia/tetraparesis 1 O75792,Q5TBB1 179 6.78e-03 5 4 1 0.250 0.200 GO:0033567 BP 1 DNA replication, Okazaki fragment processing 1 O75792 179 6.78e-03 5 4 1 0.250 0.200 GO:0008174 MF 1 mRNA methyltransferase activity 1 Q8N1G2 179 6.99e-03 49 4 2 0.500 0.041 HP:0000253 hp 1 Progressive microcephaly 1 O75792,Q5TBB1 179 8.07e-03 217 4 2 0.500 0.009 GO:0006401 BP 1 RNA catabolic process 1 O75792,Q5TBB1 179 8.14e-03 6 4 1 0.250 0.167 GO:0080009 BP 1 mRNA methylation 1 Q8N1G2 179 8.14e-03 6 4 1 0.250 0.167 GO:0004523 MF 1 RNA-DNA hybrid ribonuclease activity 1 O75792 179 8.80e-03 55 4 2 0.500 0.036 HP:0000444 hp 1 Convex nasal ridge 1 O75792,Q5TBB1 179 9.12e-03 56 4 2 0.500 0.036 HP:0002415 hp 1 Leukodystrophy 1 O75792,Q5TBB1 179 1.09e-02 8 4 1 0.250 0.125 GO:0016556 BP 1 mRNA modification 1 Q8N1G2 179 1.23e-02 65 4 2 0.500 0.031 HP:0001945 hp 1 Fever 1 O75792,Q5TBB1 179 1.26e-02 66 4 2 0.500 0.030 HP:0002062 hp 1 Morphological abnormality of the pyramidal tract 1 O75792,Q5TBB1 179 1.42e-02 70 4 2 0.500 0.029 HP:0002134 hp 1 Abnormality of the basal ganglia 1 O75792,Q5TBB1 179 1.46e-02 71 4 2 0.500 0.028 HP:0001360 hp 1 Holoprosencephaly 1 O75792,Q5TBB1 179 1.46e-02 71 4 2 0.500 0.028 HP:0003819 hp 1 Death in childhood 1 O75792,Q5TBB1 179 1.46e-02 71 4 2 0.500 0.028 HP:0006753 hp 1 Neoplasm of the stomach 1 O75792,Q5TBB1 179 1.49e-02 11 4 1 0.250 0.091 GO:0006273 BP 1 lagging strand elongation 1 O75792 179 1.50e-02 72 4 2 0.500 0.028 HP:0001876 hp 1 Pancytopenia 1 O75792,Q5TBB1 179 1.50e-02 72 4 2 0.500 0.028 HP:0001285 hp 1 Spastic tetraparesis 1 O75792,Q5TBB1 179 1.54e-02 73 4 2 0.500 0.027 HP:0002352 hp 1 Leukoencephalopathy 1 O75792,Q5TBB1 179 1.57e-02 304 4 2 0.500 0.007 GO:0034655 BP 1 nucleobase-containing compound catabolic process 1 O75792,Q5TBB1 179 1.67e-02 76 4 2 0.500 0.026 HP:0012448 hp 1 Delayed myelination 1 O75792,Q5TBB1 179 1.85e-02 80 4 2 0.500 0.025 HP:0002187 hp 1 Intellectual disability, profound 1 O75792,Q5TBB1 179 1.85e-02 80 4 2 0.500 0.025 HP:0000100 hp 1 Nephrotic syndrome 1 O75792,Q5TBB1 179 1.85e-02 80 4 2 0.500 0.025 HP:0001258 hp 1 Spastic paraplegia 1 O75792,Q5TBB1 179 1.89e-02 334 4 2 0.500 0.006 GO:0046700 BP 1 heterocycle catabolic process 1 O75792,Q5TBB1 179 1.91e-02 336 4 2 0.500 0.006 GO:0044270 BP 1 cellular nitrogen compound catabolic process 1 O75792,Q5TBB1 179 1.94e-02 82 4 2 0.500 0.024 HP:0010550 hp 1 Paraplegia 1 O75792,Q5TBB1 179 1.96e-02 340 4 2 0.500 0.006 GO:0019439 BP 1 aromatic compound catabolic process 1 O75792,Q5TBB1 179 1.99e-02 83 4 2 0.500 0.024 HP:0009145 hp 1 Abnormality of cerebral artery 1 O75792,Q5TBB1 179 2.04e-02 84 4 2 0.500 0.024 HP:0011895 hp 1 Anemia due to reduced life span of red cells 1 O75792,Q5TBB1 179 2.04e-02 84 4 2 0.500 0.024 HP:0001878 hp 1 Hemolytic anemia 1 O75792,Q5TBB1 179 2.08e-02 85 4 2 0.500 0.024 HP:0006887 hp 1 Intellectual disability, progressive 1 O75792,Q5TBB1 179 2.13e-02 86 4 2 0.500 0.023 HP:0000952 hp 1 Jaundice 1 O75792,Q5TBB1 179 2.15e-02 357 4 2 0.500 0.006 GO:1901361 BP 1 organic cyclic compound catabolic process 1 O75792,Q5TBB1 179 2.17e-02 16 4 1 0.250 0.062 GO:0008171 MF 1 O-methyltransferase activity 1 Q8N1G2 179 2.23e-02 88 4 2 0.500 0.023 HP:0012145 hp 1 Abnormality of multiple cell lineages in the bone marrow 1 O75792,Q5TBB1 179 2.31e-02 338 4 2 0.500 0.006 MI:hsa-miR-19b-2* mi 1 MI:hsa-miR-19b-2* 1 Q5TBB1,Q7Z3E2 179 2.33e-02 90 4 2 0.500 0.022 HP:0000737 hp 1 Irritability 1 O75792,Q5TBB1 179 2.38e-02 91 4 2 0.500 0.022 HP:0011344 hp 1 Severe global developmental delay 1 O75792,Q5TBB1 179 2.39e-02 713 4 2 0.500 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q8N1G2,Q7Z3E2 179 2.43e-02 92 4 2 0.500 0.022 HP:0002063 hp 1 Rigidity 1 O75792,Q5TBB1 179 2.59e-02 95 4 2 0.500 0.021 HP:0002514 hp 1 Cerebral calcification 1 O75792,Q5TBB1 179 2.61e-02 360 4 2 0.500 0.006 MI:mmu-miR-692 mi 1 MI:mmu-miR-692 1 O75792,Q5TBB1 179 2.98e-02 22 4 1 0.250 0.045 GO:0016891 MF 1 endoribonuclease activity, producing 5'-phosphomonoesters 1 O75792 179 3.21e-02 106 4 2 0.500 0.019 HP:0002061 hp 1 Lower limb spasticity 1 O75792,Q5TBB1 179 3.33e-02 108 4 2 0.500 0.019 HP:0002540 hp 1 Inability to walk 1 O75792,Q5TBB1 179 3.38e-02 25 4 1 0.250 0.040 GO:0006271 BP 1 DNA strand elongation involved in DNA replication 1 O75792 179 3.38e-02 25 4 1 0.250 0.040 GO:0016893 MF 1 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1 O75792 179 3.58e-02 112 4 2 0.500 0.018 HP:0010551 hp 1 Paraplegia/paraparesis 1 O75792,Q5TBB1 179 3.77e-02 906 4 2 0.500 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q8N1G2,Q7Z3E2 179 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q8N1G2,Q7Z3E2 179 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 Q8N1G2,Q7Z3E2 179 3.92e-02 29 4 1 0.250 0.034 GO:0006298 BP 1 mismatch repair 1 O75792 179 3.93e-02 927 4 2 0.500 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 Q8N1G2,Q7Z3E2 179 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q8N1G2,Q7Z3E2 179 4.23e-02 122 4 2 0.500 0.016 HP:0010701 hp 1 Abnormal immunoglobulin level 1 O75792,Q5TBB1 179 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q8N1G2,Q7Z3E2 179 4.30e-02 123 4 2 0.500 0.016 HP:0008936 hp 1 Muscular hypotonia of the trunk 1 O75792,Q5TBB1 179 4.33e-02 466 4 2 0.500 0.004 MI:hsa-miR-627 mi 1 MI:hsa-miR-627 1 Q8N1G2,Q7Z3E2 179 4.33e-02 32 4 1 0.250 0.031 GO:0022616 BP 1 DNA strand elongation 1 O75792 179 4.33e-02 32 4 1 0.250 0.031 GO:0006370 BP 1 7-methylguanosine mRNA capping 1 Q8N1G2 179 4.36e-02 124 4 2 0.500 0.016 HP:0005372 hp 1 Abnormality of B cell physiology 1 O75792,Q5TBB1 179 4.38e-02 469 4 2 0.500 0.004 MI:hsa-let-7f mi 1 MI:hsa-let-7f 1 O75792,Q5TBB1 179 4.43e-02 125 4 2 0.500 0.016 HP:0002846 hp 1 Abnormality of B cells 1 O75792,Q5TBB1 179 4.57e-02 127 4 2 0.500 0.016 HP:0001396 hp 1 Cholestasis 1 O75792,Q5TBB1 179 4.60e-02 34 4 1 0.250 0.029 GO:0009452 BP 1 7-methylguanosine RNA capping 1 Q8N1G2 179 4.66e-02 484 4 2 0.500 0.004 MI:hsa-let-7d mi 1 MI:hsa-let-7d 1 O75792,Q5TBB1 179 4.73e-02 35 4 1 0.250 0.029 GO:0036260 BP 1 RNA capping 1 Q8N1G2 179 4.78e-02 130 4 2 0.500 0.015 HP:0002910 hp 1 Elevated hepatic transaminases 1 O75792,Q5TBB1 179 4.98e-02 501 4 2 0.500 0.004 MI:hsa-let-7i mi 1 MI:hsa-let-7i 1 O75792,Q5TBB1 179 5.00e-02 38 4 2 0.500 0.053 OMIM:308350 omi 1 Early Infantile Epileptic Encephalopathy 1 O75792,Q5TBB1 179 5.00e-02 37 4 1 0.250 0.027 GO:0004521 MF 1 endoribonuclease activity 1 O75792 179 5.00e-02 36 4 2 0.500 0.056 KEGG:03030 keg 1 DNA replication 1 O75792,Q5TBB1 179 5.00e-02 133 4 2 0.500 0.015 HP:0001005 hp 1 Dermatological manifestations of systemic disorders 1 O75792,Q5TBB1 179 5.00e-02 502 4 2 0.500 0.004 MI:hsa-let-7g mi 1 MI:hsa-let-7g 1 O75792,Q5TBB1 180 1.54e-03 2 2 1 0.500 0.500 GO:0015680 BP 1 intracellular copper ion transport 1 O14618 180 2.31e-03 3 2 1 0.500 0.333 GO:0016721 MF 1 oxidoreductase activity, acting on superoxide radicals as acceptor 1 O14618 180 2.31e-03 3 2 1 0.500 0.333 GO:0004784 MF 1 superoxide dismutase activity 1 O14618 180 6.94e-03 9 2 1 0.500 0.111 GO:0006825 BP 1 copper ion transport 1 O14618 180 9.25e-03 12 2 1 0.500 0.083 GO:0015035 MF 1 protein disulfide oxidoreductase activity 1 O14618 180 1.00e-02 13 2 1 0.500 0.077 GO:0000303 BP 1 response to superoxide 1 O14618 180 1.00e-02 13 2 1 0.500 0.077 GO:0071450 BP 1 cellular response to oxygen radical 1 O14618 180 1.00e-02 13 2 1 0.500 0.077 GO:0071451 BP 1 cellular response to superoxide 1 O14618 180 1.00e-02 13 2 1 0.500 0.077 GO:0019430 BP 1 removal of superoxide radicals 1 O14618 180 1.08e-02 14 2 1 0.500 0.071 GO:0000305 BP 1 response to oxygen radical 1 O14618 180 1.16e-02 15 2 1 0.500 0.067 GO:0098869 BP 1 cellular oxidant detoxification 1 O14618 180 1.39e-02 18 2 1 0.500 0.056 GO:1990748 BP 1 cellular detoxification 1 O14618 180 1.54e-02 20 2 1 0.500 0.050 GO:0098754 BP 1 detoxification 1 O14618 180 2.00e-02 26 2 1 0.500 0.038 GO:0015036 MF 1 disulfide oxidoreductase activity 1 O14618 180 2.16e-02 28 2 1 0.500 0.036 GO:0006801 BP 1 superoxide metabolic process 1 O14618 180 2.31e-02 30 2 1 0.500 0.033 GO:0005507 MF 1 copper ion binding 1 O14618 180 2.93e-02 38 2 1 0.500 0.026 GO:0009636 BP 1 response to toxic substance 1 O14618 180 2.97e-02 466 2 2 1.000 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 Q96FV2,O14618 180 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 Q96FV2,O14618 180 3.08e-02 40 2 1 0.500 0.025 GO:0016667 MF 1 oxidoreductase activity, acting on a sulfur group of donors 1 O14618 180 3.37e-02 496 2 2 1.000 0.004 MI:hsa-miR-515-5p mi 1 MI:hsa-miR-515-5p 1 Q96FV2,O14618 180 3.54e-02 46 2 1 0.500 0.022 GO:0016209 MF 1 antioxidant activity 1 O14618 180 4.62e-02 60 2 1 0.500 0.017 GO:0000041 BP 1 transition metal ion transport 1 O14618 180 5.00e-02 604 2 2 1.000 0.003 MI:hsa-miR-518f mi 1 MI:hsa-miR-518f 1 Q96FV2,O14618 180 5.00e-02 27 2 1 0.500 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 O14618 180 5.00e-02 48 2 1 0.500 0.021 KEGG:05014 keg 1 Amyotrophic lateral sclerosis (ALS) 1 O14618 180 5.00e-02 351 2 2 1.000 0.006 TF:M05629_0 tf 1 Factor: ZNF44; motif: KGATSGRGCCSC; match class: 0 1 Q96FV2,O14618 180 5.00e-02 65 2 1 0.500 0.015 GO:0034614 BP 1 cellular response to reactive oxygen species 1 O14618 181 8.96e-03 1761 4 4 1.000 0.002 TF:M04437_1 tf 1 Factor: RHOXF1; motif: NTRATCCN; match class: 1 1 Q9BXI6,Q08830,Q8WUF8,Q6PIJ6 181 2.15e-02 781 4 3 0.750 0.004 TF:M04448_0 tf 1 Factor: VENTX; motif: ANCGATTAR; match class: 0 1 Q9BXI6,Q08830,Q6PIJ6 181 2.96e-02 417 4 2 0.500 0.005 MI:hsa-miR-328 mi 1 MI:hsa-miR-328 1 Q9BXI6,Q6PIJ6 181 3.86e-02 478 4 2 0.500 0.004 MI:hsa-miR-421 mi 1 MI:hsa-miR-421 1 Q08830,Q6PIJ6 181 3.89e-02 480 4 2 0.500 0.004 MI:hsa-miR-376c mi 1 MI:hsa-miR-376c 1 Q9BXI6,Q6PIJ6 181 3.94e-02 483 4 2 0.500 0.004 MI:hsa-miR-95 mi 1 MI:hsa-miR-95 1 Q08830,Q6PIJ6 181 4.16e-02 217 4 2 0.500 0.009 TF:M04307_1 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 1 1 Q08830,Q6PIJ6 181 4.33e-02 507 4 2 0.500 0.004 MI:hsa-miR-506 mi 1 MI:hsa-miR-506 1 Q08830,Q6PIJ6 181 4.38e-02 510 4 2 0.500 0.004 MI:mmu-miR-669c mi 1 MI:mmu-miR-669c 1 Q9BXI6,Q08830 181 4.60e-02 1010 4 3 0.750 0.003 TF:M03832_0 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 0 1 Q9BXI6,Q08830,Q8WUF8 181 4.65e-02 526 4 2 0.500 0.004 MI:hsa-let-7f-1* mi 1 MI:hsa-let-7f-1* 1 Q9BXI6,Q6PIJ6 181 4.77e-02 533 4 2 0.500 0.004 MI:hsa-miR-19b mi 1 MI:hsa-miR-19b 1 Q9BXI6,Q6PIJ6 181 5.00e-02 3 4 1 0.250 0.333 HP:0002601 hp 1 Paresis of extensor muscles of the big toe 1 Q6PIJ6 181 5.00e-02 9 4 1 0.250 0.111 GO:0097202 BP 1 activation of cysteine-type endopeptidase activity 1 Q9BXI6 181 5.00e-02 1 4 1 0.250 1.000 OMIM:615575 omi 1 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IID; HMN2D;;HMN IID;;NEUROPATHY, DISTAL HEREDITARY MOTOR, TYPE IID; DHMN2D;;SPINAL MUSCULAR ATROPHY, DISTAL, AUTOSOMAL DOMINANT, CALF-PREDOMINANT 1 Q6PIJ6 181 5.00e-02 3 4 1 0.250 0.333 HP:0008959 hp 1 Distal upper limb muscle weakness 1 Q6PIJ6 181 5.00e-02 2706 4 4 1.000 0.001 TF:M01856_0 tf 1 Factor: AML3; motif: AACCACAN; match class: 0 1 Q9BXI6,Q08830,Q8WUF8,Q6PIJ6 181 5.00e-02 9 4 1 0.250 0.111 GO:0005577 CC 1 fibrinogen complex 1 Q08830 181 5.00e-02 546 4 2 0.500 0.004 MI:hsa-let-7a* mi 1 MI:hsa-let-7a* 1 Q9BXI6,Q6PIJ6 181 5.00e-02 546 4 2 0.500 0.004 MI:hsa-let-7b* mi 1 MI:hsa-let-7b* 1 Q9BXI6,Q6PIJ6 181 5.00e-02 2706 4 4 1.000 0.001 TF:M01759_0 tf 1 Factor: AML2; motif: AACCRCAA; match class: 0 1 Q9BXI6,Q08830,Q8WUF8,Q6PIJ6 182 1.19e-02 16 2 1 0.500 0.062 HP:0002509 hp 1 Limb hypertonia 1 Q8NB90 182 2.11e-02 298 2 2 1.000 0.007 MI:hsa-miR-559 mi 1 MI:hsa-miR-559 1 Q8NB90,Q9BVQ7 182 3.25e-02 44 2 1 0.500 0.023 HP:0100704 hp 1 Cortical visual impairment 1 Q8NB90 182 3.80e-02 400 2 2 1.000 0.005 MI:mmu-miR-805 mi 1 MI:mmu-miR-805 1 Q8NB90,Q9BVQ7 182 4.34e-02 59 2 1 0.500 0.017 HP:0003429 hp 1 CNS hypomyelination 1 Q8NB90 182 4.80e-02 210 2 1 0.500 0.005 GO:0007420 BP 1 brain development 1 Q8NB90 182 5.00e-02 219 2 1 0.500 0.005 GO:0060322 BP 1 head development 1 Q8NB90 182 5.00e-02 74 2 1 0.500 0.014 KEGG:03008 keg 1 Ribosome biogenesis in eukaryotes 1 Q8NB90 182 5.00e-02 183 2 2 1.000 0.011 TF:M06623_0 tf 1 Factor: ZNF778; motif: NTMAGWTTGCGC; match class: 0 1 Q8NB90,Q9BVQ7 182 5.00e-02 459 2 2 1.000 0.004 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q8NB90,Q9BVQ7 182 5.00e-02 1 2 1 0.500 1.000 OMIM:616577 omi 1 EPILEPSY, HEARING LOSS, AND MENTAL RETARDATION SYNDROME; EHLMRS 1 Q8NB90 183 2.20e-03 14 2 1 0.500 0.071 TF:M06803_0 tf 1 Factor: ZBTB11; motif: NGGGWGGGCAYA; match class: 0 1 Q5JX71 183 5.34e-03 34 2 1 0.500 0.029 TF:M06055_0 tf 1 Factor: ZNF99; motif: NGGKGAAGAYCA; match class: 0 1 Q8TF42 183 6.62e-03 1036 2 2 1.000 0.002 TF:M07253_0 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 0 1 Q5JX71,Q8TF42 183 6.62e-03 1036 2 2 1.000 0.002 TF:M01132_0 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 0 1 Q5JX71,Q8TF42 183 1.01e-02 1277 2 2 1.000 0.002 TF:M01820_0 tf 1 Factor: CREM; motif: TGACGTCASYN; match class: 0 1 Q5JX71,Q8TF42 183 1.35e-02 1478 2 2 1.000 0.001 TF:M00630_1 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 1 1 Q5JX71,Q8TF42 183 1.79e-02 1703 2 2 1.000 0.001 TF:M03835_0 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 0 1 Q5JX71,Q8TF42 183 2.08e-02 133 2 1 0.500 0.008 TF:M06387_0 tf 1 Factor: ZSCAN2; motif: NGGGWAAAACGC; match class: 0 1 Q5JX71 183 2.09e-02 134 2 1 0.500 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 Q8TF42 183 2.09e-02 134 2 1 0.500 0.007 TF:M04074_1 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 1 1 Q8TF42 183 2.65e-02 170 2 1 0.500 0.006 TF:M02021_1 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 1 1 Q5JX71 183 2.73e-02 2104 2 2 1.000 0.001 TF:M02098_0 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 0 1 Q5JX71,Q8TF42 183 2.92e-02 187 2 1 0.500 0.005 TF:M00733_1 tf 1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 1 Q8TF42 183 3.24e-02 208 2 1 0.500 0.005 TF:M06154_0 tf 1 Factor: ZNF132; motif: NTTRGAAATGTTYM; match class: 0 1 Q5JX71 183 3.25e-02 2296 2 2 1.000 0.001 TF:M07037_1 tf 1 Factor: C/EBPalpha; motif: NNNNNTTKCNNAAN; match class: 1 1 Q5JX71,Q8TF42 183 3.40e-02 218 2 1 0.500 0.005 TF:M07139_0 tf 1 Factor: USF2; motif: RYCAYGTGACY; match class: 0 1 Q8TF42 183 3.46e-02 2367 2 2 1.000 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q5JX71,Q8TF42 183 3.55e-02 228 2 1 0.500 0.004 TF:M06293_0 tf 1 Factor: ZNF742; motif: NGGGACGAGGSC; match class: 0 1 Q8TF42 183 3.58e-02 230 2 1 0.500 0.004 TF:M07298_0 tf 1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 0 1 Q8TF42 183 3.70e-02 238 2 1 0.500 0.004 TF:M03793_1 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 1 1 Q8TF42 183 3.87e-02 249 2 1 0.500 0.004 TF:M02098_1 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 1 1 Q8TF42 183 3.89e-02 2511 2 2 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q5JX71,Q8TF42 183 3.92e-02 252 2 1 0.500 0.004 TF:M01871_1 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 1 1 Q5JX71 183 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 Q5JX71 183 4.31e-02 277 2 1 0.500 0.004 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q8TF42 183 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 Q8TF42 183 4.49e-02 289 2 1 0.500 0.003 TF:M05950_0 tf 1 Factor: ZNF700; motif: NSGWGTARTTCS; match class: 0 1 Q5JX71 183 4.52e-02 2705 2 2 1.000 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q5JX71,Q8TF42 183 4.57e-02 294 2 1 0.500 0.003 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 Q5JX71 183 4.78e-02 308 2 1 0.500 0.003 TF:M07305_1 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 1 1 Q5JX71 183 4.83e-02 2797 2 2 1.000 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q5JX71,Q8TF42 183 4.89e-02 2816 2 2 1.000 0.001 TF:M07315_1 tf 1 Factor: C/EBPbeta; motif: NNTTKCNNMAN; match class: 1 1 Q5JX71,Q8TF42 183 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q8TF42 183 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q8TF42 184 1.61e-09 3 7 3 0.429 1.000 GO:0005853 CC 1 eukaryotic translation elongation factor 1 complex 1 P29692,P24534,P68104 184 3.54e-07 12 7 3 0.429 0.250 GO:0003746 MF 1 translation elongation factor activity 1 P24534,P68104,P26641 184 4.77e-07 69 7 4 0.571 0.058 GO:0008135 MF 1 translation factor activity, RNA binding 1 P29692,P24534,P68104,P26641 184 2.52e-06 104 7 4 0.571 0.038 GO:0006414 BP 1 translational elongation 1 P29692,P24534,P68104,P26641 184 2.65e-06 92 7 4 0.571 0.043 REAC:156842 rea 1 Eukaryotic Translation Elongation 1 P29692,P24534,P68104,P26641 184 2.14e-05 155 7 4 0.571 0.026 REAC:72766 rea 1 Translation 1 P29692,P24534,P68104,P26641 184 2.91e-05 483 7 5 0.714 0.010 GO:0006412 BP 1 translation 1 P29692,P24534,P68104,P26640,P26641 184 3.39e-05 498 7 5 0.714 0.010 GO:0043043 BP 1 peptide biosynthetic process 1 P29692,P24534,P68104,P26640,P26641 184 5.48e-05 549 7 5 0.714 0.009 GO:0043604 BP 1 amide biosynthetic process 1 P29692,P24534,P68104,P26640,P26641 184 7.95e-05 592 7 5 0.714 0.008 GO:0006518 BP 1 peptide metabolic process 1 P29692,P24534,P68104,P26640,P26641 184 1.89e-04 706 7 5 0.714 0.007 GO:0043603 BP 1 cellular amide metabolic process 1 P29692,P24534,P68104,P26640,P26641 184 5.67e-04 18 7 2 0.286 0.111 GO:0071364 BP 1 cellular response to epidermal growth factor stimulus 1 P68104,P26641 184 7.77e-04 21 7 2 0.286 0.095 GO:0070849 BP 1 response to epidermal growth factor 1 P68104,P26641 184 8.70e-04 965 7 5 0.714 0.005 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 P29692,P24534,P68104,P26640,P26641 184 3.92e-03 18 7 2 0.286 0.111 CORUM:1335 cor 1 SNW1 complex 1 P68104,P26641 184 4.19e-03 1336 7 5 0.714 0.004 GO:0003723 MF 1 RNA binding 1 P29692,P24534,Q86UP2,P68104,P26641 184 4.93e-03 271 7 3 0.429 0.011 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 P29692,Q86UP2,P26641 184 5.15e-03 275 7 3 0.429 0.011 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 P29692,Q86UP2,P26641 184 5.26e-03 277 7 3 0.429 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 P29692,Q86UP2,P26641 184 5.55e-03 282 7 3 0.429 0.011 GO:0045296 MF 1 cadherin binding 1 P29692,Q86UP2,P26641 184 5.91e-03 505 7 4 0.571 0.008 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 6.27e-03 294 7 3 0.429 0.010 GO:0005913 CC 1 cell-cell adherens junction 1 P29692,Q86UP2,P26641 184 7.15e-03 1 7 1 0.143 1.000 GO:0098745 CC 1 Dcp1-Dcp2 complex 1 P26641 184 7.15e-03 1 7 1 0.143 1.000 GO:1901834 BP 1 regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 P26641 184 7.15e-03 1 7 1 0.143 1.000 GO:1901835 BP 1 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 P26641 184 7.15e-03 1 7 1 0.143 1.000 GO:1904246 BP 1 negative regulation of polynucleotide adenylyltransferase activity 1 P26641 184 8.91e-03 1565 7 5 0.714 0.003 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P29692,P24534,P68104,P26640,P26641 184 1.13e-02 596 7 4 0.571 0.007 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 1.22e-02 369 7 3 0.429 0.008 GO:0050839 MF 1 cell adhesion molecule binding 1 P29692,Q86UP2,P26641 184 1.28e-02 616 7 4 0.571 0.006 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 1.34e-02 624 7 4 0.571 0.006 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 1.35e-02 625 7 4 0.571 0.006 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 1.43e-02 634 7 4 0.571 0.006 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 1.43e-02 2 7 1 0.143 0.500 GO:0045085 BP 1 negative regulation of interleukin-2 biosynthetic process 1 P26641 184 1.43e-02 2 7 1 0.143 0.500 GO:0019957 MF 1 C-C chemokine binding 1 P26641 184 1.43e-02 2 7 1 0.143 0.500 GO:1904582 BP 1 positive regulation of intracellular mRNA localization 1 P26641 184 1.43e-02 2 7 1 0.143 0.500 GO:1904580 BP 1 regulation of intracellular mRNA localization 1 P26641 184 1.43e-02 2 7 1 0.143 0.500 GO:1904245 BP 1 regulation of polynucleotide adenylyltransferase activity 1 P26641 184 1.44e-02 933 7 4 0.571 0.004 GO:0005783 CC 1 endoplasmic reticulum 1 P29692,P24534,Q86UP2,P26641 184 1.66e-02 331 7 2 0.286 0.006 MI:hsa-miR-16-1* mi 1 MI:hsa-miR-16-1* 1 P24534,Q86UP2 184 1.67e-02 1485 7 5 0.714 0.003 REAC:74160 rea 1 Gene Expression 1 P29692,P24534,P68104,P26640,P26641 184 1.77e-02 420 7 3 0.429 0.007 GO:0005911 CC 1 cell-cell junction 1 P29692,Q86UP2,P26641 184 2.15e-02 3 7 1 0.143 0.333 GO:0098574 CC 1 cytoplasmic side of lysosomal membrane 1 P68104 184 2.15e-02 3 7 1 0.143 0.333 GO:0045076 BP 1 regulation of interleukin-2 biosynthetic process 1 P26641 184 2.15e-02 3 7 1 0.143 0.333 GO:0004832 MF 1 valine-tRNA ligase activity 1 P26640 184 2.15e-02 3 7 1 0.143 0.333 GO:0006438 BP 1 valyl-tRNA aminoacylation 1 P26640 184 2.25e-02 713 7 4 0.571 0.006 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 2.28e-02 113 7 2 0.286 0.018 GO:0050678 BP 1 regulation of epithelial cell proliferation 1 Q9UHF1,P26641 184 2.36e-02 2342 7 6 0.857 0.003 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 P29692,P24534,Q86UP2,P68104,P26640,P26641 184 2.42e-02 404 7 2 0.286 0.005 MI:hsa-miR-126 mi 1 MI:hsa-miR-126 1 P68104,Q9UHF1 184 2.46e-02 408 7 2 0.286 0.005 MI:mmu-miR-351 mi 1 MI:mmu-miR-351 1 Q9UHF1,P26641 184 2.50e-02 733 7 4 0.571 0.005 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 2.75e-02 433 7 2 0.286 0.005 MI:hsa-miR-181a-2* mi 1 MI:hsa-miR-181a-2* 1 P68104,Q9UHF1 184 2.79e-02 1440 7 5 0.714 0.003 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 P29692,P24534,Q86UP2,P68104,P26640 184 2.80e-02 755 7 4 0.571 0.005 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 P29692,P24534,Q86UP2,P68104 184 2.86e-02 4 7 1 0.143 0.250 GO:0097012 BP 1 response to granulocyte macrophage colony-stimulating factor 1 P26641 184 2.86e-02 4 7 1 0.143 0.250 GO:0042094 BP 1 interleukin-2 biosynthetic process 1 P26641 184 2.86e-02 4 7 1 0.143 0.250 GO:0097011 BP 1 cellular response to granulocyte macrophage colony-stimulating factor stimulus 1 P26641 184 2.86e-02 4 7 1 0.143 0.250 GO:0031087 BP 1 deadenylation-independent decapping of nuclear-transcribed mRNA 1 P26641 184 2.88e-02 3 7 1 0.143 0.333 TF:M05873_0 tf 1 Factor: ZNF710; motif: NAAATAGGCATGTC; match class: 0 1 P24534 184 2.88e-02 3 7 1 0.143 0.333 TF:M06499_0 tf 1 Factor: znf383; motif: NGGTGGATAGGA; match class: 0 1 P26641 184 2.92e-02 447 7 2 0.286 0.004 MI:hsa-miR-876-3p mi 1 MI:hsa-miR-876-3p 1 P68104,Q9UHF1 184 2.95e-02 449 7 2 0.286 0.004 MI:hsa-miR-337-3p mi 1 MI:hsa-miR-337-3p 1 P24534,P26641 184 3.11e-02 462 7 2 0.286 0.004 MI:hsa-miR-323-5p mi 1 MI:hsa-miR-323-5p 1 P68104,Q9UHF1 184 3.15e-02 133 7 2 0.286 0.015 GO:0050673 BP 1 epithelial cell proliferation 1 Q9UHF1,P26641 184 3.19e-02 3899 7 7 1.000 0.002 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 P29692,P24534,Q86UP2,P68104,Q9UHF1,P26640,P26641 184 3.36e-02 11 7 1 0.143 0.091 REAC:5625970 rea 1 RHO GTPases activate KTN1 1 Q86UP2 184 3.55e-02 496 7 2 0.286 0.004 MI:hsa-miR-628-5p mi 1 MI:hsa-miR-628-5p 1 Q86UP2,P68104 184 3.57e-02 5 7 1 0.143 0.200 GO:0031086 BP 1 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 1 P26641 184 3.71e-02 508 7 2 0.286 0.004 MI:hsa-miR-451 mi 1 MI:hsa-miR-451 1 Q86UP2,P68104 184 3.81e-02 516 7 2 0.286 0.004 MI:hsa-miR-199a-3p mi 1 MI:hsa-miR-199a-3p 1 Q86UP2,Q9UHF1 184 3.85e-02 2136 7 5 0.714 0.002 GO:0003676 MF 1 nucleic acid binding 1 P29692,P24534,Q86UP2,P68104,P26641 184 4.06e-02 534 7 2 0.286 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 P68104,Q9UHF1 184 4.13e-02 836 7 4 0.571 0.005 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 4.29e-02 6 7 1 0.143 0.167 GO:0097283 BP 1 keratinocyte apoptotic process 1 P26641 184 4.29e-02 6 7 1 0.143 0.167 GO:0045647 BP 1 negative regulation of erythrocyte differentiation 1 P26641 184 4.29e-02 6 7 1 0.143 0.167 GO:1902172 BP 1 regulation of keratinocyte apoptotic process 1 P26641 184 4.31e-02 550 7 3 0.429 0.005 TF:M00490_0 tf 1 Factor: Bach2; motif: SRTGAGTCANC; match class: 0 1 P24534,P68104,P26640 184 4.43e-02 4086 7 7 1.000 0.002 HPA:027020_02 hpa 1 pancreas; islets of Langerhans[Uncertain,Medium] 1 P29692,P24534,Q86UP2,P68104,Q9UHF1,P26640,P26641 184 4.53e-02 582 7 3 0.429 0.005 GO:0005912 CC 1 adherens junction 1 P29692,Q86UP2,P26641 184 4.73e-02 591 7 3 0.429 0.005 GO:0070161 CC 1 anchoring junction 1 P29692,Q86UP2,P26641 184 4.87e-02 150 7 2 0.286 0.013 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 P24534,P68104 184 4.89e-02 874 7 4 0.571 0.005 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 P29692,P24534,Q86UP2,P68104 184 5.00e-02 369 7 3 0.429 0.008 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 P24534,Q86UP2,P68104 184 5.00e-02 7 7 1 0.143 0.143 GO:1904714 BP 1 regulation of chaperone-mediated autophagy 1 P68104 184 5.00e-02 3635 7 6 0.857 0.002 TF:M00927_0 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 0 1 P29692,P24534,P68104,Q9UHF1,P26640,P26641 184 5.00e-02 5 7 1 0.143 0.200 CORUM:5269 cor 1 TNF-alpha/NF-kappa B signaling complex 8 1 Q86UP2 184 5.00e-02 7 7 1 0.143 0.143 GO:0070578 CC 1 RISC-loading complex 1 P26641 184 5.00e-02 1169 7 4 0.571 0.003 REAC:392499 rea 1 Metabolism of proteins 1 P29692,P24534,P68104,P26641 185 1.94e-03 1 3 1 0.333 1.000 OMIM:615500 omi 1 CILIARY DYSKINESIA, PRIMARY, 26; CILD26;;CILIARY DYSKINESIA, PRIMARY, 26, WITH OR WITHOUT SITUS INVERSUS 1 P57076 185 2.50e-03 1 3 1 0.333 1.000 GO:0080058 BP 1 protein deglutathionylation 1 P35754 185 2.50e-03 1 3 1 0.333 1.000 GO:0097573 MF 1 glutathione oxidoreductase activity 1 P35754 185 2.94e-03 4 3 1 0.333 0.250 KEGG:00400 keg 1 Phenylalanine, tyrosine and tryptophan biosynthesis 1 P00505 185 4.47e-03 19 3 1 0.333 0.053 TF:M06853_0 tf 1 Factor: ZNF528; motif: GGAATGGGTCGTGGBKTM; match class: 0 1 P00505 185 5.01e-03 2 3 1 0.333 0.500 GO:0006533 BP 1 aspartate catabolic process 1 P00505 185 5.01e-03 2 3 1 0.333 0.500 GO:0004069 MF 1 L-aspartate:2-oxoglutarate aminotransferase activity 1 P00505 185 5.65e-03 24 3 1 0.333 0.042 TF:M04136_1 tf 1 Factor: TBX4; motif: AGGTGTGANAWNTNACACCT; match class: 1 1 P35754 185 7.29e-03 31 3 1 0.333 0.032 TF:M03964_0 tf 1 Factor: EBF1; motif: ANTCCCNWGGGAMT; match class: 0 1 P35754 185 8.34e-03 684 3 2 0.667 0.003 TF:M01591_1 tf 1 Factor: Tal-1; motif: CTTCCTTMTCTSY; match class: 1 1 P57076,P35754 185 8.46e-03 36 3 1 0.333 0.028 TF:M06115_0 tf 1 Factor: ZNF28; motif: NGGGGCGGCAGC; match class: 0 1 P57076 185 8.79e-03 12 3 1 0.333 0.083 KEGG:00360 keg 1 Phenylalanine metabolism 1 P00505 185 9.83e-03 2727 3 3 1.000 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 P00505,P57076,P35754 185 1.00e-02 4 3 1 0.333 0.250 GO:0019470 BP 1 4-hydroxyproline catabolic process 1 P00505 185 1.08e-02 46 3 1 0.333 0.022 TF:M06889_0 tf 1 Factor: znf658b; motif: NTGGNGAAGAGC; match class: 0 1 P35754 185 1.08e-02 46 3 1 0.333 0.022 TF:M06890_0 tf 1 Factor: ZNF658; motif: NTGGNGAAGAGC; match class: 0 1 P35754 185 1.17e-02 50 3 1 0.333 0.020 TF:M06161_0 tf 1 Factor: ZNF117; motif: NGGGGAGGACGM; match class: 0 1 P00505 185 1.24e-02 17 3 1 0.333 0.059 KEGG:01210 keg 1 2-Oxocarboxylic acid metabolism 1 P00505 185 1.25e-02 5 3 1 0.333 0.200 GO:0045838 BP 1 positive regulation of membrane potential 1 P35754 185 1.25e-02 5 3 1 0.333 0.200 GO:0015038 MF 1 glutathione disulfide oxidoreductase activity 1 P35754 185 1.27e-02 54 3 1 0.333 0.019 TF:M04459_0 tf 1 Factor: ESRRB; motif: TCAAGGTCAWN; match class: 0 1 P00505 185 1.38e-02 59 3 1 0.333 0.017 TF:M04136_0 tf 1 Factor: TBX4; motif: AGGTGTGANAWNTNACACCT; match class: 0 1 P35754 185 1.39e-02 19 3 1 0.333 0.053 KEGG:00220 keg 1 Arginine biosynthesis 1 P00505 185 1.48e-02 63 3 1 0.333 0.016 TF:M06647_0 tf 1 Factor: ZNF665; motif: NGGKCTTKATGA; match class: 0 1 P35754 185 1.50e-02 6 3 1 0.333 0.167 GO:0015037 MF 1 peptide disulfide oxidoreductase activity 1 P35754 185 1.59e-02 68 3 1 0.333 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 P57076 185 1.61e-02 22 3 1 0.333 0.045 KEGG:04975 keg 1 Fat digestion and absorption 1 P00505 185 1.69e-02 72 3 1 0.333 0.014 TF:M05456_0 tf 1 Factor: gsh-1; motif: TCCTTATTAAA; match class: 0 1 P35754 185 1.69e-02 72 3 1 0.333 0.014 TF:M05340_0 tf 1 Factor: HOXB2; motif: NCCTTATTAAA; match class: 0 1 P35754 185 1.69e-02 72 3 1 0.333 0.014 TF:M05338_0 tf 1 Factor: HOXB3; motif: NCCTTATTAAA; match class: 0 1 P35754 185 1.75e-02 7 3 1 0.333 0.143 GO:0019471 BP 1 4-hydroxyproline metabolic process 1 P00505 185 1.75e-02 7 3 1 0.333 0.143 GO:0006531 BP 1 aspartate metabolic process 1 P00505 185 1.76e-02 75 3 1 0.333 0.013 TF:M00224_1 tf 1 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN; match class: 1 1 P57076 185 1.79e-02 1010 3 2 0.667 0.002 TF:M02000_1 tf 1 Factor: ERR3; motif: CAAGGTCA; match class: 1 1 P00505,P35754 185 1.79e-02 1010 3 2 0.667 0.002 TF:M00727_1 tf 1 Factor: SF-1; motif: TGACCTTG; match class: 1 1 P00505,P35754 185 1.83e-02 1021 3 2 0.667 0.002 TF:M03566_0 tf 1 Factor: SNA; motif: GCCACCTGNCNGYN; match class: 0 1 P57076,P35754 185 1.98e-02 1065 3 2 0.667 0.002 TF:M01971_0 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 0 1 P57076,P35754 185 2.01e-02 86 3 1 0.333 0.012 TF:M06025_0 tf 1 Factor: ZNF195; motif: NGWGKAAGCTGC; match class: 0 1 P35754 185 2.05e-02 28 3 1 0.333 0.036 KEGG:00350 keg 1 Tyrosine metabolism 1 P00505 185 2.06e-02 88 3 1 0.333 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 P57076 185 2.12e-02 29 3 1 0.333 0.034 KEGG:00250 keg 1 Alanine, aspartate and glutamate metabolism 1 P00505 185 2.25e-02 9 3 1 0.333 0.111 GO:2000651 BP 1 positive regulation of sodium ion transmembrane transporter activity 1 P35754 185 2.36e-02 101 3 1 0.333 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 P00505 185 2.50e-02 107 3 1 0.333 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 P57076 185 2.50e-02 10 3 1 0.333 0.100 GO:0042219 BP 1 cellular modified amino acid catabolic process 1 P00505 185 2.69e-02 115 3 1 0.333 0.009 TF:M01826_1 tf 1 Factor: PITX1; motif: GMMACTAATCY; match class: 1 1 P35754 185 2.75e-02 11 3 1 0.333 0.091 GO:0043649 BP 1 dicarboxylic acid catabolic process 1 P00505 185 2.84e-02 3293 3 3 1.000 0.001 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 P00505,P57076,P35754 185 3.00e-02 12 3 1 0.333 0.083 GO:1902307 BP 1 positive regulation of sodium ion transmembrane transport 1 P35754 185 3.00e-02 12 3 1 0.333 0.083 GO:0015035 MF 1 protein disulfide oxidoreductase activity 1 P35754 185 3.03e-02 130 3 1 0.333 0.008 TF:M07328_0 tf 1 Factor: NF-AT5; motif: KGKRWTTTTCCAN; match class: 0 1 P35754 185 3.03e-02 130 3 1 0.333 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 P00505 185 3.10e-02 3998 3 3 1.000 0.001 TF:M01599_0 tf 1 Factor: FOXP3; motif: RTAAACAA; match class: 0 1 P00505,P57076,P35754 185 3.13e-02 43 3 1 0.333 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 P00505 185 3.13e-02 43 3 1 0.333 0.023 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 P00505 185 3.15e-02 135 3 1 0.333 0.007 TF:M05362_0 tf 1 Factor: NKX1-1; motif: WTAATAWGGA; match class: 0 1 P35754 185 3.25e-02 13 3 1 0.333 0.077 GO:0045471 BP 1 response to ethanol 1 P00505 185 3.25e-02 13 3 1 0.333 0.077 GO:0006103 BP 1 2-oxoglutarate metabolic process 1 P00505 185 3.38e-02 145 3 1 0.333 0.007 TF:M07264_1 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 1 1 P35754 185 3.57e-02 27 3 1 0.333 0.037 HP:0012260 hp 1 Abnormal central microtubular pair morphology of respiratory motile cilia 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0005938 hp 1 Abnormal respiratory motile cilium morphology 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0200073 hp 1 Respiratory insufficiency due to defective ciliary clearance 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012267 hp 1 Absent respiratory ciliary axoneme radial spokes 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012255 hp 1 Dynein arm defect of respiratory motile cilia 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012258 hp 1 Abnormal axonemal organization of respiratory motile cilia 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0200109 hp 1 Absent/shortened outer dynein arms 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0200106 hp 1 Absent/shortened dynein arms 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012253 hp 1 Abnormal respiratory epithelium morphology 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012257 hp 1 Absent inner dynein arms 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012259 hp 1 Absent inner and outer dynein arms 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0200108 hp 1 Shortened outer dynein arms 1 P57076 185 3.57e-02 27 3 1 0.333 0.037 HP:0012256 hp 1 Absent outer dynein arms 1 P57076 185 3.58e-02 1446 3 2 0.667 0.001 TF:M07327_1 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 1 1 P57076,P35754 185 3.70e-02 280 3 2 0.667 0.007 MI:hsa-miR-335* mi 1 MI:hsa-miR-335* 1 P57076,P35754 185 3.70e-02 28 3 1 0.333 0.036 HP:0012208 hp 1 Nonmotile sperm 1 P57076 185 3.70e-02 28 3 1 0.333 0.036 HP:0012265 hp 1 Ciliary dyskinesia 1 P57076 185 3.72e-02 160 3 1 0.333 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 P57076 185 3.84e-02 165 3 1 0.333 0.006 TF:M03842_0 tf 1 Factor: POU3F1; motif: RNYBCATTTGCATTWCAA; match class: 0 1 P57076 185 3.91e-02 25 3 1 0.333 0.040 REAC:499943 rea 1 Synthesis and interconversion of nucleotide di- and triphosphates 1 P35754 185 3.93e-02 1519 3 2 0.667 0.001 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 P57076,P35754 185 3.96e-02 30 3 1 0.333 0.033 HP:0012207 hp 1 Reduced sperm motility 1 P57076 185 3.96e-02 30 3 1 0.333 0.033 HP:0012206 hp 1 Abnormal sperm motility 1 P57076 185 4.03e-02 1539 3 2 0.667 0.001 TF:M00241_0 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 0 1 P00505,P57076 185 4.05e-02 174 3 1 0.333 0.006 TF:M05721_0 tf 1 Factor: ZNF235; motif: NCYKTCGAGAGA; match class: 0 1 P00505 185 4.07e-02 26 3 1 0.333 0.038 REAC:70614 rea 1 Amino acid synthesis and interconversion (transamination) 1 P00505 185 4.09e-02 31 3 1 0.333 0.032 HP:0012735 hp 1 Cough 1 P57076 185 4.09e-02 31 3 1 0.333 0.032 HP:0002257 hp 1 Chronic rhinitis 1 P57076 185 4.16e-02 179 3 1 0.333 0.006 TF:M06744_0 tf 1 Factor: ZNF228; motif: NACTAAAKCAGR; match class: 0 1 P00505 185 4.23e-02 182 3 1 0.333 0.005 TF:M06292_0 tf 1 Factor: ZNF766; motif: NCGTGAAGGAAA; match class: 0 1 P00505 185 4.24e-02 4438 3 3 1.000 0.001 TF:M00727_0 tf 1 Factor: SF-1; motif: TGACCTTG; match class: 0 1 P00505,P57076,P35754 185 4.24e-02 4438 3 3 1.000 0.001 TF:M02000_0 tf 1 Factor: ERR3; motif: CAAGGTCA; match class: 0 1 P00505,P57076,P35754 185 4.25e-02 17 3 1 0.333 0.059 GO:0008483 MF 1 transaminase activity 1 P00505 185 4.35e-02 33 3 1 0.333 0.030 HP:0100582 hp 1 Nasal polyposis 1 P57076 185 4.36e-02 1360 3 2 0.667 0.001 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P00505,P57076 185 4.39e-02 4492 3 3 1.000 0.001 TF:M00339_0 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 0 1 P00505,P57076,P35754 185 4.41e-02 1614 3 2 0.667 0.001 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 P00505,P57076 185 4.41e-02 1614 3 2 0.667 0.001 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 P57076,P35754 185 4.41e-02 1369 3 2 0.667 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 P00505,P35754 185 4.48e-02 34 3 1 0.333 0.029 HP:0000389 hp 1 Chronic otitis media 1 P57076 185 4.48e-02 34 3 1 0.333 0.029 HP:0012384 hp 1 Rhinitis 1 P57076 185 4.50e-02 18 3 1 0.333 0.056 GO:0009068 BP 1 aspartate family amino acid catabolic process 1 P00505 185 4.50e-02 18 3 1 0.333 0.056 GO:0006536 BP 1 glutamate metabolic process 1 P00505 185 4.61e-02 35 3 1 0.333 0.029 HP:0002688 hp 1 Absent frontal sinuses 1 P57076 185 4.61e-02 35 3 1 0.333 0.029 HP:0004469 hp 1 Chronic bronchitis 1 P57076 185 4.61e-02 35 3 1 0.333 0.029 HP:0011109 hp 1 Chronic sinusitis 1 P57076 185 4.63e-02 4572 3 3 1.000 0.001 TF:M00472_0 tf 1 Factor: FOXO4; motif: RWAAACAANNN; match class: 0 1 P00505,P57076,P35754 185 4.69e-02 202 3 1 0.333 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 P57076 185 4.71e-02 203 3 1 0.333 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 P35754 185 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 P00505,P57076,P35754 185 4.74e-02 36 3 1 0.333 0.028 HP:0000433 hp 1 Abnormality of the nasal mucosa 1 P57076 185 4.74e-02 36 3 1 0.333 0.028 HP:0009119 hp 1 Aplasia/Hypoplasia of the frontal sinuses 1 P57076 185 4.74e-02 36 3 1 0.333 0.028 HP:0001748 hp 1 Polysplenia 1 P57076 185 4.74e-02 36 3 1 0.333 0.028 HP:0002687 hp 1 Abnormality of frontal sinus 1 P57076 185 4.75e-02 19 3 1 0.333 0.053 GO:0016769 MF 1 transferase activity, transferring nitrogenous groups 1 P00505 185 4.82e-02 1690 3 2 0.667 0.001 TF:M03802_1 tf 1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 1 P00505,P35754 185 4.94e-02 213 3 1 0.333 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 P57076 185 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P00505,P57076 185 5.00e-02 38 3 1 0.333 0.026 HP:0009120 hp 1 Aplasia/Hypoplasia involving the sinuses 1 P57076 185 5.00e-02 69 3 1 0.333 0.014 KEGG:01230 keg 1 Biosynthesis of amino acids 1 P00505 185 5.00e-02 32 3 1 0.333 0.031 REAC:70263 rea 1 Gluconeogenesis 1 P00505 185 5.00e-02 26 3 1 0.333 0.038 OMIM:244400 omi 1 Primary Ciliary Dyskinesia 1 P57076 185 5.00e-02 20 3 1 0.333 0.050 GO:0010765 BP 1 positive regulation of sodium ion transport 1 P35754 185 5.00e-02 326 3 2 0.667 0.006 MI:hsa-miR-182* mi 1 MI:hsa-miR-182* 1 P57076,P35754 186 3.57e-03 1 2 1 0.500 1.000 GO:0070539 MF 1 linoleic acid binding 1 Q03181 186 1.07e-02 3 2 1 0.500 0.333 GO:0046697 BP 1 decidualization 1 Q03181 186 1.07e-02 3 2 1 0.500 0.333 GO:0031417 CC 1 NatC complex 1 Q147X3 186 1.43e-02 4 2 1 0.500 0.250 GO:0001893 BP 1 maternal placenta development 1 Q03181 186 2.14e-02 6 2 1 0.500 0.167 GO:0060135 BP 1 maternal process involved in female pregnancy 1 Q03181 186 2.14e-02 6 2 1 0.500 0.167 GO:1902894 BP 1 negative regulation of pri-miRNA transcription from RNA polymerase II promoter 1 Q03181 186 2.14e-02 6 2 1 0.500 0.167 GO:0017196 BP 1 N-terminal peptidyl-methionine acetylation 1 Q147X3 186 2.50e-02 7 2 1 0.500 0.143 GO:0036041 MF 1 long-chain fatty acid binding 1 Q03181 186 3.21e-02 9 2 1 0.500 0.111 GO:0004596 MF 1 peptide alpha-N-acetyltransferase activity 1 Q147X3 186 3.57e-02 10 2 1 0.500 0.100 GO:0031414 CC 1 N-terminal protein acetyltransferase complex 1 Q147X3 186 3.57e-02 10 2 1 0.500 0.100 GO:0007566 BP 1 embryo implantation 1 Q03181 186 4.29e-02 12 2 1 0.500 0.083 GO:0018206 BP 1 peptidyl-methionine modification 1 Q147X3 186 4.64e-02 13 2 1 0.500 0.077 GO:0003707 MF 1 steroid hormone receptor activity 1 Q03181 186 4.90e-02 278 2 1 0.500 0.004 MI:hsa-miR-550* mi 1 MI:hsa-miR-550* 1 Q03181 186 4.91e-02 52 2 1 0.500 0.019 KEGG:05221 keg 1 Acute myeloid leukemia 1 Q03181 186 5.00e-02 14 2 1 0.500 0.071 GO:0006474 BP 1 N-terminal protein amino acid acetylation 1 Q147X3 186 5.00e-02 53 2 1 0.500 0.019 KEGG:03320 keg 1 PPAR signaling pathway 1 Q03181 186 5.00e-02 10 2 1 0.500 0.100 REAC:200425 rea 1 Import of palmitoyl-CoA into the mitochondrial matrix 1 Q03181 186 5.00e-02 6 2 1 0.500 0.167 TF:M07213_1 tf 1 Factor: GATA2; motif: NNNTTCTTATCTSN; match class: 1 1 Q03181 187 3.23e-04 35 2 2 1.000 0.057 GO:0020037 MF 1 heme binding 1 O43169,P99999 187 3.61e-04 37 2 2 1.000 0.054 GO:0046906 MF 1 tetrapyrrole binding 1 O43169,P99999 187 1.12e-03 2 2 1 0.500 0.500 REAC:111457 rea 1 Release of apoptotic factors from the mitochondria 1 P99999 187 1.68e-03 3 2 1 0.500 0.333 REAC:111458 rea 1 Formation of apoptosome 1 P99999 187 2.79e-03 5 2 1 0.500 0.200 REAC:111459 rea 1 Activation of caspases through apoptosome-mediated cleavage 1 P99999 187 2.79e-03 5 2 1 0.500 0.200 REAC:111461 rea 1 Cytochrome c-mediated apoptotic response 1 P99999 187 3.58e-03 1 2 1 0.500 1.000 OMIM:612004 omi 1 THROMBOCYTOPENIA 4; THC4;;THROMBOCYTOPENIA, AUTOSOMAL DOMINANT, 4 1 P99999 187 3.91e-03 7 2 1 0.500 0.143 REAC:111471 rea 1 Apoptotic factor-mediated response 1 P99999 187 1.25e-02 2 2 1 0.500 0.500 GO:0045155 MF 1 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity 1 P99999 187 1.35e-02 1254 2 2 1.000 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 O43169,P99999 187 1.51e-02 27 2 1 0.500 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 P99999 187 1.70e-02 1408 2 2 1.000 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 O43169,P99999 187 1.79e-02 5 2 1 0.500 0.200 OMIM:313900 omi 1 Hereditary Thrombocytopenia 1 P99999 187 1.83e-02 1462 2 2 1.000 0.001 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 O43169,P99999 187 2.15e-02 1583 2 2 1.000 0.001 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 O43169,P99999 187 2.17e-02 39 2 1 0.500 0.026 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 P99999 187 2.34e-02 42 2 1 0.500 0.024 REAC:2151201 rea 1 Transcriptional activation of mitochondrial biogenesis 1 P99999 187 2.54e-02 1722 2 2 1.000 0.001 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 O43169,P99999 187 2.84e-02 51 2 1 0.500 0.020 REAC:1592230 rea 1 Mitochondrial biogenesis 1 P99999 187 3.33e-02 16 2 1 0.500 0.062 TF:M04036_0 tf 1 Factor: PKNOX1; motif: TGACAGSTGTCA; match class: 0 1 O43169 187 3.33e-02 16 2 1 0.500 0.062 TF:M04037_0 tf 1 Factor: PKNOX2; motif: TGACAGGTGTCA; match class: 0 1 O43169 187 3.75e-02 18 2 1 0.500 0.056 TF:M05534_0 tf 1 Factor: PRDM14; motif: NTGDCTGGAAGM; match class: 0 1 P99999 187 4.07e-02 2177 2 2 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 O43169,P99999 187 4.39e-02 79 2 1 0.500 0.013 REAC:5628897 rea 1 TP53 Regulates Metabolic Genes 1 P99999 187 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 O43169,P99999 187 4.48e-02 2286 2 2 1.000 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 O43169,P99999 187 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 O43169,P99999 187 5.00e-02 14 2 1 0.500 0.071 OMIM:231200 omi 1 Platelet-Type Bleeding Disorders 1 P99999 187 5.00e-02 24 2 1 0.500 0.042 TF:M04471_1 tf 1 Factor: NR2E1; motif: AAGTCAANAAGTCA; match class: 1 1 P99999 187 5.00e-02 90 2 1 0.500 0.011 REAC:611105 rea 1 Respiratory electron transport 1 P99999 187 5.00e-02 10 2 1 0.500 0.100 KEGG:00920 keg 1 Sulfur metabolism 1 P99999 187 5.00e-02 2 2 1 0.500 0.500 CORUM:1248 cor 1 Apoptosome 1 P99999 187 5.00e-02 8 2 1 0.500 0.125 GO:0008635 BP 1 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 1 P99999 188 1.08e-05 5 4 2 0.500 0.400 GO:0016272 CC 1 prefoldin complex 1 Q9UHV9,P61758 188 1.09e-04 6 4 2 0.500 0.333 CORUM:33 cor 1 Prefoldin 1 Q9UHV9,P61758 188 1.09e-04 6 4 2 0.500 0.333 CORUM:112 cor 1 Prefoldin complex 1 Q9UHV9,P61758 188 4.21e-04 26 4 2 0.500 0.077 REAC:389957 rea 1 Prefoldin mediated transfer of substrate to CCT/TriC 1 Q9UHV9,P61758 188 5.63e-04 30 4 2 0.500 0.067 REAC:389958 rea 1 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1 Q9UHV9,P61758 188 8.67e-04 16 4 2 0.500 0.125 CORUM:5199 cor 1 Kinase maturation complex 1 1 Q9NUG6,Q9UHV9 188 4.68e-03 86 4 2 0.500 0.023 REAC:390466 rea 1 Chaperonin-mediated protein folding 1 Q9UHV9,P61758 188 5.36e-03 92 4 2 0.500 0.022 REAC:391251 rea 1 Protein folding 1 Q9UHV9,P61758 188 8.34e-03 2 4 1 0.250 0.500 GO:0004779 MF 1 sulfate adenylyltransferase activity 1 O95340 188 8.34e-03 2 4 1 0.250 0.500 GO:0004020 MF 1 adenylylsulfate kinase activity 1 O95340 188 8.34e-03 2 4 1 0.250 0.500 GO:0004781 MF 1 sulfate adenylyltransferase (ATP) activity 1 O95340 188 1.25e-02 4 4 1 0.250 0.250 REAC:2408550 rea 1 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1 O95340 188 1.32e-02 1 4 1 0.250 1.000 TF:M01028_1 tf 1 Factor: NRSF; motif: GYRCTGTCCRYGGTGCTGA; match class: 1 1 Q9NUG6 188 1.57e-02 5 4 1 0.250 0.200 REAC:174362 rea 1 Transport and synthesis of PAPS 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0006413 hp 1 Broad tibial metaphyses 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0004002 hp 1 Flattened radial epiphyses 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0008418 hp 1 Squared-off platyspondyly 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0003854 hp 1 Sclerosis of metaphyses of the upper limbs 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0005004 hp 1 Flattened proximal radial epiphyses 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0006607 hp 1 Precocious costochondral ossification 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0003952 hp 1 Sclerotic foci of metaphyses of the elbow 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0003949 hp 1 Abnormality of the elbow metaphyses 1 O95340 188 1.67e-02 1 4 1 0.250 1.000 HP:0008922 hp 1 Childhood-onset short-trunk short stature 1 O95340 188 2.09e-02 5 4 1 0.250 0.200 GO:0000103 BP 1 sulfate assimilation 1 O95340 188 2.09e-02 5 4 1 0.250 0.200 GO:0050428 BP 1 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 1 O95340 188 2.09e-02 5 4 1 0.250 0.200 GO:0034036 BP 1 purine ribonucleoside bisphosphate biosynthetic process 1 O95340 188 2.09e-02 5 4 1 0.250 0.200 GO:0007021 BP 1 tubulin complex assembly 1 P61758 188 2.66e-02 433 4 2 0.500 0.005 MI:hsa-miR-181a-2* mi 1 MI:hsa-miR-181a-2* 1 Q9NUG6,P61758 188 2.79e-02 711 4 3 0.750 0.004 TF:M07136_0 tf 1 Factor: TCF-4; motif: NNASATCAAAGNNN; match class: 0 1 Q9NUG6,P61758,O95340 188 3.10e-02 469 4 2 0.500 0.004 MI:mmu-miR-685 mi 1 MI:mmu-miR-685 1 Q9NUG6,Q9UHV9 188 3.13e-02 10 4 1 0.250 0.100 KEGG:00920 keg 1 Sulfur metabolism 1 O95340 188 3.23e-02 747 4 3 0.750 0.004 TF:M02269_1 tf 1 Factor: FEV; motif: CAGGAART; match class: 1 1 Q9NUG6,P61758,O95340 188 3.34e-02 2 4 1 0.250 0.500 HP:0006491 hp 1 Abnormality of the tibial metaphysis 1 O95340 188 3.34e-02 2 4 1 0.250 0.500 HP:0012066 hp 1 Increased urinary disaccharide excretion 1 O95340 188 3.34e-02 487 4 2 0.500 0.004 MI:hsa-miR-301b mi 1 MI:hsa-miR-301b 1 Q9UHV9,P61758 188 3.61e-02 507 4 2 0.500 0.004 MI:hsa-miR-768-3p mi 1 MI:hsa-miR-768-3p 1 P61758,O95340 188 3.72e-02 515 4 2 0.500 0.004 MI:hsa-miR-301a mi 1 MI:hsa-miR-301a 1 Q9UHV9,P61758 188 3.92e-02 529 4 2 0.500 0.004 MI:hsa-miR-548b-5p mi 1 MI:hsa-miR-548b-5p 1 Q9UHV9,P61758 188 4.17e-02 10 4 1 0.250 0.100 GO:0044183 MF 1 protein binding involved in protein folding 1 Q9UHV9 188 5.00e-02 12 4 1 0.250 0.083 GO:0034030 BP 1 ribonucleoside bisphosphate biosynthetic process 1 O95340 188 5.00e-02 16 4 1 0.250 0.062 KEGG:00450 keg 1 Selenocompound metabolism 1 O95340 188 5.00e-02 9 4 1 0.250 0.111 CORUM:781 cor 1 URI complex (Unconventional prefoldin RPB5 Interactor) 1 Q9UHV9 188 5.00e-02 12 4 1 0.250 0.083 GO:0033866 BP 1 nucleoside bisphosphate biosynthetic process 1 O95340 188 5.00e-02 3 4 1 0.250 0.333 HP:0003999 hp 1 Abnormality of radial epiphyses 1 O95340 188 5.00e-02 3 4 1 0.250 0.333 HP:0010597 hp 1 Abnormality of the distal radial epiphysis 1 O95340 188 5.00e-02 1 4 1 0.250 1.000 OMIM:612847 omi 1 BRACHYOLMIA TYPE 4 WITH MILD EPIPHYSEAL AND METAPHYSEAL CHANGES; BCYM4;;SPONDYLOEPIMETAPHYSEAL DYSPLASIA, PAKISTANI TYPE;;SEMD, PAKISTANI TYPE;;SPONDYLODYSPLASIA AND PREMATURE PUBARCHE 1 O95340 188 5.00e-02 3 4 1 0.250 0.333 HP:0004626 hp 1 Lumbar scoliosis 1 O95340 188 5.00e-02 16 4 1 0.250 0.062 REAC:156584 rea 1 Cytosolic sulfonation of small molecules 1 O95340 188 5.00e-02 866 4 3 0.750 0.003 TF:M07285_1 tf 1 Factor: ESE-1; motif: NNYTTCCTG; match class: 1 1 Q9NUG6,P61758,O95340 188 5.00e-02 600 4 2 0.500 0.003 MI:mmu-miR-466d-5p mi 1 MI:mmu-miR-466d-5p 1 Q9NUG6,O95340 188 5.00e-02 12 4 1 0.250 0.083 GO:0034033 BP 1 purine nucleoside bisphosphate biosynthetic process 1 O95340 189 1.88e-03 1 4 1 0.250 1.000 OMIM:615889 omi 1 LEUKOENCEPHALOPATHY, PROGRESSIVE, WITH OVARIAN FAILURE; LKENP 1 Q5JTZ9 189 1.88e-03 1 4 1 0.250 1.000 OMIM:615575 omi 1 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IID; HMN2D;;HMN IID;;NEUROPATHY, DISTAL HEREDITARY MOTOR, TYPE IID; DHMN2D;;SPINAL MUSCULAR ATROPHY, DISTAL, AUTOSOMAL DOMINANT, CALF-PREDOMINANT 1 Q6PIJ6 189 1.88e-03 1 4 1 0.250 1.000 OMIM:614096 omi 1 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 8; COXPD8;;CARDIOMYOPATHY, HYPERTROPHIC MITOCHONDRIAL, FATAL INFANTILE 1 Q5JTZ9 189 8.19e-03 425 4 2 0.500 0.005 MI:hsa-miR-615-3p mi 1 MI:hsa-miR-615-3p 1 Q5JTZ9,Q6PIJ6 189 8.42e-03 431 4 2 0.500 0.005 MI:hsa-miR-433 mi 1 MI:hsa-miR-433 1 Q08830,Q5JTZ9 189 1.00e-02 1 4 1 0.250 1.000 GO:0070143 BP 1 mitochondrial alanyl-tRNA aminoacylation 1 Q5JTZ9 189 1.03e-02 478 4 2 0.500 0.004 MI:hsa-miR-421 mi 1 MI:hsa-miR-421 1 Q08830,Q6PIJ6 189 1.05e-02 483 4 2 0.500 0.004 MI:hsa-miR-95 mi 1 MI:hsa-miR-95 1 Q08830,Q6PIJ6 189 1.06e-02 486 4 2 0.500 0.004 MI:hsa-miR-34c-3p mi 1 MI:hsa-miR-34c-3p 1 Q08830,Q5JTZ9 189 1.09e-02 491 4 2 0.500 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 Q08830,Q5JTZ9 189 1.15e-02 507 4 2 0.500 0.004 MI:hsa-miR-506 mi 1 MI:hsa-miR-506 1 Q08830,Q6PIJ6 189 2.00e-02 2 4 1 0.250 0.500 GO:0006419 BP 1 alanyl-tRNA aminoacylation 1 Q5JTZ9 189 2.00e-02 2 4 1 0.250 0.500 GO:0004813 MF 1 alanine-tRNA ligase activity 1 Q5JTZ9 189 2.51e-02 21 4 1 0.250 0.048 REAC:379726 rea 1 Mitochondrial tRNA aminoacylation 1 Q5JTZ9 189 3.83e-02 1975 4 4 1.000 0.002 TF:M07340_1 tf 1 Factor: TEF-1; motif: ACATTCCWSNN; match class: 1 1 Q08830,Q8WUF8,Q5JTZ9,Q6PIJ6 189 5.00e-02 5 4 1 0.250 0.200 GO:0070127 BP 1 tRNA aminoacylation for mitochondrial protein translation 1 Q5JTZ9 189 5.00e-02 3 4 1 0.250 0.333 HP:0002601 hp 1 Paresis of extensor muscles of the big toe 1 Q6PIJ6 189 5.00e-02 3 4 1 0.250 0.333 HP:0006980 hp 1 Progressive leukoencephalopathy 1 Q5JTZ9 189 5.00e-02 42 4 1 0.250 0.024 REAC:379724 rea 1 tRNA Aminoacylation 1 Q5JTZ9 189 5.00e-02 3 4 1 0.250 0.333 HP:0008959 hp 1 Distal upper limb muscle weakness 1 Q6PIJ6 189 5.00e-02 44 4 1 0.250 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 Q5JTZ9 190 9.72e-04 231 3 2 0.667 0.009 TF:M07310_0 tf 1 Factor: Sp5; motif: ACCSCGCCKCCSS; match class: 0 1 O95758,Q5VYK3 190 3.36e-03 1907 3 3 1.000 0.002 TF:M03892_0 tf 1 Factor: VDR:RXR-alpha; motif: RRGGTCAN; match class: 0 1 O95758,Q5VYK3,P42765 190 3.78e-03 458 3 2 0.667 0.004 TF:M04625_1 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 1 1 Q5VYK3,P42765 190 7.52e-03 32 3 1 0.333 0.031 TF:M06708_0 tf 1 Factor: ZNF355P; motif: NSGTGGAACCGM; match class: 0 1 Q5VYK3 190 8.70e-03 37 3 1 0.333 0.027 TF:M05742_0 tf 1 Factor: ZNF57; motif: NSRAMGGGCAGG; match class: 0 1 P42765 190 8.70e-03 37 3 1 0.333 0.027 TF:M06703_0 tf 1 Factor: ZNF160; motif: NGGKAAAAATGA; match class: 0 1 Q5VYK3 190 1.10e-02 47 3 1 0.333 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 Q5VYK3 190 1.17e-02 50 3 1 0.333 0.020 TF:M06764_0 tf 1 Factor: ZNF228; motif: NCCGCCGAACCC; match class: 0 1 Q5VYK3 190 1.25e-02 1 3 1 0.333 1.000 GO:1905709 BP 1 negative regulation of membrane permeability 1 P42765 190 1.25e-02 1 3 1 0.333 1.000 GO:1902109 BP 1 negative regulation of mitochondrial membrane permeability involved in apoptotic process 1 P42765 190 1.25e-02 1 3 1 0.333 1.000 GO:0035795 BP 1 negative regulation of mitochondrial membrane permeability 1 P42765 190 1.40e-02 3066 3 3 1.000 0.001 TF:M02273_0 tf 1 Factor: NURR1; motif: AAGGTCAC; match class: 0 1 O95758,Q5VYK3,P42765 190 1.85e-02 3370 3 3 1.000 0.001 TF:M00192_0 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 0 1 O95758,Q5VYK3,P42765 190 2.57e-02 110 3 1 0.333 0.009 TF:M06215_0 tf 1 Factor: ZNF33b; motif: NTGTCCAANGGA; match class: 0 1 Q5VYK3 190 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 P42765 190 2.73e-02 3832 3 3 1.000 0.001 TF:M01035_1 tf 1 Factor: YY1; motif: NYNKCCATNTT; match class: 1 1 O95758,Q5VYK3,P42765 190 2.91e-02 3915 3 3 1.000 0.001 TF:M00205_0 tf 1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 0 1 O95758,Q5VYK3,P42765 190 2.94e-02 126 3 1 0.333 0.008 TF:M00478_1 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 1 1 P42765 190 3.44e-02 290 3 2 0.667 0.007 MI:hsa-miR-132* mi 1 MI:hsa-miR-132* 1 Q5VYK3,P42765 190 3.53e-02 1437 3 2 0.667 0.001 TF:M01279_0 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 0 1 O95758,Q5VYK3 190 3.56e-02 153 3 1 0.333 0.007 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 O95758 190 3.57e-02 4190 3 3 1.000 0.001 TF:M00747_1 tf 1 Factor: IRF-1; motif: TTCACTT; match class: 1 1 O95758,Q5VYK3,P42765 190 3.61e-02 1453 3 2 0.667 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 O95758,Q5VYK3 190 3.67e-02 1465 3 2 0.667 0.001 TF:M01284_1 tf 1 Factor: SOX9; motif: RNACAAAGGVN; match class: 1 1 O95758,P42765 190 3.88e-02 4310 3 3 1.000 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 O95758,Q5VYK3,P42765 190 4.25e-02 183 3 1 0.333 0.005 TF:M06623_0 tf 1 Factor: ZNF778; motif: NTMAGWTTGCGC; match class: 0 1 P42765 190 4.26e-02 4447 3 3 1.000 0.001 TF:M03998_0 tf 1 Factor: GATA4; motif: WGATAANN; match class: 0 1 O95758,Q5VYK3,P42765 190 4.41e-02 1614 3 2 0.667 0.001 TF:M04352_0 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 0 1 O95758,Q5VYK3 190 4.54e-02 1638 3 2 0.667 0.001 TF:M04339_0 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 0 1 O95758,Q5VYK3 190 4.59e-02 1648 3 2 0.667 0.001 TF:M00252_1 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 1 1 O95758,Q5VYK3 190 4.84e-02 1694 3 2 0.667 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 O95758,Q5VYK3 190 4.92e-02 4665 3 3 1.000 0.001 TF:M00117_1 tf 1 Factor: C/EBPbeta; motif: NKNTTGCNYAAYNN; match class: 1 1 O95758,Q5VYK3,P42765 190 5.00e-02 21 3 1 0.333 0.048 KEGG:00062 keg 1 Fatty acid elongation 1 P42765 190 5.00e-02 350 3 2 0.667 0.006 MI:hsa-miR-26a-1* mi 1 MI:hsa-miR-26a-1* 1 O95758,P42765 190 5.00e-02 20 3 1 0.333 0.050 REAC:77289 rea 1 Mitochondrial Fatty Acid Beta-Oxidation 1 P42765 190 5.00e-02 4 3 1 0.333 0.250 GO:1901029 BP 1 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 P42765 191 1.34e-05 10 4 2 0.500 0.200 REAC:1236977 rea 1 Endosomal/Vacuolar pathway 1 P10321,P13747 191 6.87e-05 22 4 2 0.500 0.091 REAC:983170 rea 1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1 P10321,P13747 191 2.20e-04 39 4 2 0.500 0.051 REAC:909733 rea 1 Interferon alpha/beta signaling 1 P10321,P13747 191 3.10e-04 18 4 2 0.500 0.111 KEGG:05330 keg 1 Allograft rejection 1 P10321,P13747 191 3.48e-04 49 4 2 0.500 0.041 REAC:198933 rea 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1 P10321,P13747 191 3.85e-04 20 4 2 0.500 0.100 KEGG:05332 keg 1 Graft-versus-host disease 1 P10321,P13747 191 3.92e-04 145 4 3 0.750 0.021 KEGG:05168 keg 1 Herpes simplex infection 1 Q9NZJ5,P10321,P13747 191 5.08e-04 8 4 2 0.500 0.250 TF:M07100_1 tf 1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 1 1 P10321,P13747 191 5.12e-04 23 4 2 0.500 0.087 KEGG:04940 keg 1 Type I diabetes mellitus 1 P10321,P13747 191 6.32e-04 66 4 2 0.500 0.030 REAC:877300 rea 1 Interferon gamma signaling 1 P10321,P13747 191 7.10e-04 27 4 2 0.500 0.074 KEGG:05320 keg 1 Autoimmune thyroid disease 1 P10321,P13747 191 7.49e-04 180 4 3 0.750 0.017 KEGG:05169 keg 1 Epstein-Barr virus infection 1 Q9NZJ5,P10321,P13747 191 9.06e-04 79 4 2 0.500 0.025 REAC:1236974 rea 1 ER-Phagosome pathway 1 P10321,P13747 191 1.12e-03 88 4 2 0.500 0.023 REAC:1236975 rea 1 Antigen processing-Cross presentation 1 P10321,P13747 191 1.41e-03 13 4 2 0.500 0.154 TF:M04010_1 tf 1 Factor: HSF4; motif: TTCTAGAANNTTC; match class: 1 1 P10321,P13747 191 1.90e-03 44 4 2 0.500 0.045 KEGG:05416 keg 1 Viral myocarditis 1 P10321,P13747 191 1.99e-03 45 4 2 0.500 0.044 KEGG:04612 keg 1 Antigen processing and presentation 1 P10321,P13747 191 3.16e-03 148 4 2 0.500 0.014 REAC:913531 rea 1 Interferon Signaling 1 P10321,P13747 191 5.39e-03 74 4 2 0.500 0.027 KEGG:04514 keg 1 Cell adhesion molecules (CAMs) 1 P10321,P13747 191 6.94e-03 84 4 2 0.500 0.024 KEGG:04650 keg 1 Natural killer cell mediated cytotoxicity 1 P10321,P13747 191 7.17e-03 1 4 1 0.250 1.000 OMIM:615065 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 5D; DA5D 1 O95672 191 7.17e-03 1 4 1 0.250 1.000 OMIM:226980 omi 1 EPIPHYSEAL DYSPLASIA, MULTIPLE, WITH EARLY-ONSET DIABETES MELLITUS;;MED-IDDM SYNDROME;;IDDM-MED SYNDROME;;WOLCOTT-RALLISON SYNDROME 1 Q9NZJ5 191 1.00e-02 1 4 1 0.250 1.000 GO:0060734 BP 1 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 1 Q9NZJ5 191 1.22e-02 294 4 2 0.500 0.007 REAC:2172127 rea 1 DAP12 interactions 1 P10321,P13747 191 1.38e-02 104 4 2 0.500 0.019 GO:0030176 CC 1 integral component of endoplasmic reticulum membrane 1 Q9NZJ5,P10321 191 1.43e-02 2 4 1 0.250 0.500 OMIM:108145 omi 1 Distal Arthrogryposis 5 1 O95672 191 1.45e-02 322 4 2 0.500 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 P10321,P13747 191 1.49e-02 108 4 2 0.500 0.019 GO:0031227 CC 1 intrinsic component of endoplasmic reticulum membrane 1 Q9NZJ5,P10321 191 1.50e-02 124 4 2 0.500 0.016 KEGG:04145 keg 1 Phagosome 1 P10321,P13747 191 1.72e-02 24 4 1 0.250 0.042 REAC:381042 rea 1 PERK regulates gene expression 1 Q9NZJ5 191 2.00e-02 2 4 1 0.250 0.500 GO:0031642 BP 1 negative regulation of myelination 1 Q9NZJ5 191 2.31e-02 351 4 2 0.500 0.006 MI:hsa-miR-130a* mi 1 MI:hsa-miR-130a* 1 P10321,P13747 191 2.33e-02 352 4 2 0.500 0.006 MI:hsa-miR-125b-2* mi 1 MI:hsa-miR-125b-2* 1 Q9NZJ5,P10321 191 2.54e-02 162 4 2 0.500 0.012 KEGG:05203 keg 1 Viral carcinogenesis 1 P10321,P13747 191 2.72e-02 446 4 2 0.500 0.004 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 P10321,P13747 191 3.00e-02 3 4 1 0.250 0.333 GO:0042612 CC 1 MHC class I protein complex 1 P10321 191 3.00e-02 3 4 1 0.250 0.333 GO:0031645 BP 1 negative regulation of neurological system process 1 Q9NZJ5 191 3.88e-02 457 4 2 0.500 0.004 MI:hsa-miR-224 mi 1 MI:hsa-miR-224 1 Q9NZJ5,P10321 191 3.99e-02 464 4 2 0.500 0.004 MI:hsa-miR-575 mi 1 MI:hsa-miR-575 1 O95672,Q9NZJ5 191 4.00e-02 4 4 1 0.250 0.250 GO:0004694 MF 1 eukaryotic translation initiation factor 2alpha kinase activity 1 Q9NZJ5 191 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q9NZJ5,P13747 191 4.13e-02 472 4 2 0.500 0.004 MI:hsa-miR-133a mi 1 MI:hsa-miR-133a 1 O95672,P10321 191 4.14e-02 473 4 2 0.500 0.004 MI:hsa-miR-133b mi 1 MI:hsa-miR-133b 1 O95672,P10321 191 4.37e-02 486 4 2 0.500 0.004 MI:hsa-miR-27b mi 1 MI:hsa-miR-27b 1 O95672,P10321 191 4.40e-02 488 4 2 0.500 0.004 MI:hsa-miR-27a mi 1 MI:hsa-miR-27a 1 O95672,P10321 191 4.53e-02 495 4 2 0.500 0.004 MI:hsa-miR-152 mi 1 MI:hsa-miR-152 1 O95672,P10321 191 4.54e-02 218 4 2 0.500 0.009 KEGG:05166 keg 1 HTLV-I infection 1 P10321,P13747 191 4.60e-02 499 4 2 0.500 0.004 MI:hsa-miR-128a mi 1 MI:hsa-miR-128a 1 O95672,P10321 191 5.00e-02 5 4 1 0.250 0.200 GO:0036492 BP 1 eiF2alpha phosphorylation in response to endoplasmic reticulum stress 1 Q9NZJ5 191 5.00e-02 1 4 1 0.250 1.000 HP:0010168 hp 1 Ivory epiphyses of the toes 1 Q9NZJ5 191 5.00e-02 1 4 1 0.250 1.000 HP:0010160 hp 1 Abnormality of the epiphyses of the toes 1 Q9NZJ5 191 5.00e-02 7 4 1 0.250 0.143 OMIM:108120 omi 1 Distal Arthrogryposes 1 O95672 191 5.00e-02 229 4 2 0.500 0.009 KEGG:04144 keg 1 Endocytosis 1 P10321,P13747 191 5.00e-02 521 4 2 0.500 0.004 MI:hsa-miR-148a mi 1 MI:hsa-miR-148a 1 O95672,P10321 191 5.00e-02 75 4 2 0.500 0.027 TF:M06507_0 tf 1 Factor: ZFP90; motif: NGGGASTTTAKA; match class: 0 1 P10321,P13747 191 5.00e-02 614 4 2 0.500 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 P10321,P13747 191 5.00e-02 5 4 1 0.250 0.200 GO:0036491 BP 1 regulation of translation initiation in response to endoplasmic reticulum stress 1 Q9NZJ5 191 5.00e-02 5 4 1 0.250 0.200 GO:0002063 BP 1 chondrocyte development 1 Q9NZJ5 191 5.00e-02 1 4 1 0.250 1.000 HP:0006274 hp 1 Reduced pancreatic beta cells 1 Q9NZJ5 191 5.00e-02 1 4 1 0.250 1.000 HP:0010631 hp 1 Abnormality of the epiphyses of the feet 1 Q9NZJ5 191 5.00e-02 1 4 1 0.250 1.000 HP:0008134 hp 1 Irregular tarsal ossification 1 Q9NZJ5 192 1.43e-03 408 2 2 1.000 0.005 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 P61326,O15020 192 1.74e-03 2 2 1 0.500 0.500 CORUM:763 cor 1 Y14-Magoh complex 1 P61326 192 1.74e-03 2 2 1 0.500 0.500 CORUM:773 cor 1 Y14-Magoh complex 1 P61326 192 2.01e-03 484 2 2 1.000 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P61326,O15020 192 2.47e-03 537 2 2 1.000 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 P61326,O15020 192 2.61e-03 3 2 1 0.500 0.333 CORUM:1293 cor 1 IPO13-RBM8A-MAGOH complex 1 P61326 192 3.12e-03 9 2 1 0.500 0.111 GO:0008091 CC 1 spectrin 1 O15020 192 3.44e-03 634 2 2 1.000 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P61326,O15020 192 3.48e-03 4 2 1 0.500 0.250 CORUM:740 cor 1 Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex) 1 P61326 192 3.48e-03 4 2 1 0.500 0.250 CORUM:769 cor 1 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex 1 P61326 192 3.48e-03 4 2 1 0.500 0.250 CORUM:754 cor 1 Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14) 1 P61326 192 3.48e-03 4 2 1 0.500 0.250 CORUM:744 cor 1 Exon junction complex (EIF4A3-MLN51-MAGOH-Y14) 1 P61326 192 4.34e-03 5 2 1 0.500 0.200 CORUM:755 cor 1 Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM) 1 P61326 192 5.99e-03 836 2 2 1.000 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P61326,O15020 192 6.08e-03 7 2 1 0.500 0.143 CORUM:785 cor 1 Exon junction complex 1 P61326 192 6.91e-03 25 2 1 0.500 0.040 REAC:445095 rea 1 Interaction between L1 and Ankyrins 1 O15020 192 7.08e-03 909 2 2 1.000 0.002 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 P61326,O15020 192 7.28e-03 21 2 1 0.500 0.048 GO:0035145 CC 1 exon-exon junction complex 1 P61326 192 9.01e-03 26 2 1 0.500 0.038 GO:0000381 BP 1 regulation of alternative mRNA splicing, via spliceosome 1 P61326 192 1.14e-02 1152 2 2 1.000 0.002 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 P61326,O15020 192 1.14e-02 33 2 1 0.500 0.030 GO:0000380 BP 1 alternative mRNA splicing, via spliceosome 1 P61326 192 1.32e-02 1241 2 2 1.000 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 P61326,O15020 192 1.39e-02 1274 2 2 1.000 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P61326,O15020 192 1.42e-02 41 2 1 0.500 0.024 GO:0030864 CC 1 cortical actin cytoskeleton 1 O15020 192 1.43e-02 1291 2 2 1.000 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 P61326,O15020 192 1.43e-02 52 2 1 0.500 0.019 REAC:72187 rea 1 mRNA 3'-end processing 1 P61326 192 1.45e-02 42 2 1 0.500 0.024 GO:0048024 BP 1 regulation of mRNA splicing, via spliceosome 1 P61326 192 1.47e-02 1308 2 2 1.000 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P61326,O15020 192 1.67e-02 1396 2 2 1.000 0.001 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P61326,O15020 192 1.68e-02 61 2 1 0.500 0.016 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 P61326 192 1.68e-02 61 2 1 0.500 0.016 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 P61326 192 1.73e-02 50 2 1 0.500 0.020 GO:0030863 CC 1 cortical cytoskeleton 1 O15020 192 1.85e-02 285 2 2 1.000 0.007 MI:hsa-miR-18a* mi 1 MI:hsa-miR-18a* 1 P61326,O15020 192 1.87e-02 68 2 1 0.500 0.015 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 P61326 192 1.95e-02 1508 2 2 1.000 0.001 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 P61326,O15020 192 1.96e-02 1513 2 2 1.000 0.001 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P61326,O15020 192 1.98e-02 1521 2 2 1.000 0.001 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P61326,O15020 192 2.01e-02 73 2 1 0.500 0.014 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 O15020 192 2.02e-02 1535 2 2 1.000 0.001 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P61326,O15020 192 2.07e-02 75 2 1 0.500 0.013 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 P61326 192 2.12e-02 1574 2 2 1.000 0.001 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P61326,O15020 192 2.13e-02 1576 2 2 1.000 0.001 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P61326,O15020 192 2.18e-02 63 2 1 0.500 0.016 GO:0006369 BP 1 termination of RNA polymerase II transcription 1 P61326 192 2.30e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 P61326,O15020 192 2.36e-02 1659 2 2 1.000 0.001 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P61326,O15020 192 2.39e-02 1670 2 2 1.000 0.001 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 P61326,O15020 192 2.42e-02 70 2 1 0.500 0.014 GO:0044448 CC 1 cell cortex part 1 O15020 192 2.42e-02 70 2 1 0.500 0.014 GO:0050684 BP 1 regulation of mRNA processing 1 P61326 192 2.46e-02 71 2 1 0.500 0.014 GO:0005200 MF 1 structural constituent of cytoskeleton 1 O15020 192 2.50e-02 2 2 1 0.500 0.500 HP:0008003 hp 1 Jerky ocular pursuit movements 1 O15020 192 2.56e-02 93 2 1 0.500 0.011 REAC:373760 rea 1 L1CAM interactions 1 O15020 192 2.60e-02 141 2 1 0.500 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 O15020 192 2.61e-02 95 2 1 0.500 0.011 REAC:2132295 rea 1 MHC class II antigen presentation 1 O15020 192 2.64e-02 1756 2 2 1.000 0.001 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P61326,O15020 192 2.70e-02 78 2 1 0.500 0.013 GO:0043484 BP 1 regulation of RNA splicing 1 P61326 192 2.72e-02 1782 2 2 1.000 0.001 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P61326,O15020 192 2.74e-02 1787 2 2 1.000 0.001 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P61326,O15020 192 2.80e-02 81 2 1 0.500 0.012 GO:0019886 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class II 1 O15020 192 2.82e-02 1813 2 2 1.000 0.001 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P61326,O15020 192 2.83e-02 1818 2 2 1.000 0.001 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P61326,O15020 192 2.84e-02 82 2 1 0.500 0.012 GO:0002495 BP 1 antigen processing and presentation of peptide antigen via MHC class II 1 O15020 192 2.86e-02 1825 2 2 1.000 0.001 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P61326,O15020 192 2.87e-02 83 2 1 0.500 0.012 GO:0002504 BP 1 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1 O15020 192 2.87e-02 83 2 1 0.500 0.012 GO:0031124 BP 1 mRNA 3'-end processing 1 P61326 192 2.98e-02 1863 2 2 1.000 0.001 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P61326,O15020 192 3.04e-02 88 2 1 0.500 0.011 GO:0071013 CC 1 catalytic step 2 spliceosome 1 P61326 192 3.10e-02 113 2 1 0.500 0.009 REAC:927802 rea 1 Nonsense-Mediated Decay (NMD) 1 P61326 192 3.10e-02 113 2 1 0.500 0.009 REAC:975957 rea 1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1 P61326 192 3.11e-02 90 2 1 0.500 0.011 GO:1903311 BP 1 regulation of mRNA metabolic process 1 P61326 192 3.13e-02 1909 2 2 1.000 0.001 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P61326,O15020 192 3.18e-02 1924 2 2 1.000 0.001 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P61326,O15020 192 3.20e-02 1932 2 2 1.000 0.001 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P61326,O15020 192 3.25e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 P61326 192 3.27e-02 119 2 1 0.500 0.008 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 O15020 192 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P61326,O15020 192 3.35e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 P61326,O15020 192 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P61326,O15020 192 3.42e-02 99 2 1 0.500 0.010 GO:0006353 BP 1 DNA-templated transcription, termination 1 P61326 192 3.46e-02 100 2 1 0.500 0.010 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 P61326 192 3.46e-02 100 2 1 0.500 0.010 GO:0006406 BP 1 mRNA export from nucleus 1 P61326 192 3.58e-02 2043 2 2 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P61326,O15020 192 3.59e-02 104 2 1 0.500 0.010 GO:0051028 BP 1 mRNA transport 1 P61326 192 3.62e-02 2055 2 2 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P61326,O15020 192 3.64e-02 2060 2 2 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P61326,O15020 192 3.68e-02 2072 2 2 1.000 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 P61326,O15020 192 3.73e-02 108 2 1 0.500 0.009 GO:0097485 BP 1 neuron projection guidance 1 O15020 192 3.73e-02 108 2 1 0.500 0.009 GO:0007411 BP 1 axon guidance 1 O15020 192 3.76e-02 109 2 1 0.500 0.009 GO:0031123 BP 1 RNA 3'-end processing 1 P61326 192 3.82e-02 2110 2 2 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P61326,O15020 192 3.83e-02 111 2 1 0.500 0.009 GO:0006405 BP 1 RNA export from nucleus 1 P61326 192 3.84e-02 140 2 1 0.500 0.007 REAC:73857 rea 1 RNA Polymerase II Transcription 1 P61326 192 3.87e-02 112 2 1 0.500 0.009 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 P61326 192 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P61326,O15020 192 3.89e-02 142 2 1 0.500 0.007 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 O15020 192 3.92e-02 2139 2 2 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P61326,O15020 192 3.97e-02 115 2 1 0.500 0.009 GO:0071166 BP 1 ribonucleoprotein complex localization 1 P61326 192 3.97e-02 115 2 1 0.500 0.009 GO:0000184 BP 1 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1 P61326 192 3.97e-02 115 2 1 0.500 0.009 GO:0005938 CC 1 cell cortex 1 O15020 192 3.98e-02 2154 2 2 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 P61326,O15020 192 4.11e-02 2188 2 2 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P61326,O15020 192 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P61326,O15020 192 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P61326,O15020 192 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P61326,O15020 192 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P61326,O15020 192 4.21e-02 122 2 1 0.500 0.008 GO:0099568 CC 1 cytoplasmic region 1 O15020 192 4.31e-02 125 2 1 0.500 0.008 GO:0050657 BP 1 nucleic acid transport 1 P61326 192 4.31e-02 125 2 1 0.500 0.008 GO:0050658 BP 1 RNA transport 1 P61326 192 4.42e-02 128 2 1 0.500 0.008 GO:0051236 BP 1 establishment of RNA localization 1 P61326 192 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P61326,O15020 192 4.44e-02 2274 2 2 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P61326,O15020 192 4.44e-02 2274 2 2 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P61326,O15020 192 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.46e-02 2281 2 2 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.48e-02 2286 2 2 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P61326,O15020 192 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P61326,O15020 192 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P61326,O15020 192 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 P61326,O15020 192 4.73e-02 173 2 1 0.500 0.006 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P61326 192 4.82e-02 8 2 1 0.500 0.125 TF:M06665_1 tf 1 Factor: ZNF599; motif: NCGTGMTRAAA; match class: 1 1 P61326 192 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P61326,O15020 192 4.90e-02 142 2 1 0.500 0.007 GO:0015931 BP 1 nucleobase-containing compound transport 1 P61326 192 4.92e-02 180 2 1 0.500 0.006 REAC:72172 rea 1 mRNA Splicing 1 P61326 192 4.93e-02 143 2 1 0.500 0.007 GO:0002478 BP 1 antigen processing and presentation of exogenous peptide antigen 1 O15020 192 4.97e-02 144 2 1 0.500 0.007 GO:0019884 BP 1 antigen processing and presentation of exogenous antigen 1 O15020 192 4.99e-02 128 2 1 0.500 0.008 KEGG:03040 keg 1 Spliceosome 1 P61326 192 5.00e-02 1 2 1 0.500 1.000 OMIM:600224 omi 1 SPINOCEREBELLAR ATAXIA 5; SCA5 1 O15020 192 5.00e-02 4 2 1 0.500 0.250 HP:0000317 hp 1 Facial myokymia 1 O15020 192 5.00e-02 1 2 1 0.500 1.000 OMIM:615386 omi 1 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 14; SCAR14;;CEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, SPECTRIN-ASSOCIATED, 1; SPARCA1 1 O15020 192 5.00e-02 460 2 2 1.000 0.004 TF:M01031_1 tf 1 Factor: HNF-4; motif: NGGNCAAAGKYCAN; match class: 1 1 P61326,O15020 192 5.00e-02 145 2 1 0.500 0.007 GO:0005088 MF 1 Ras guanyl-nucleotide exchange factor activity 1 O15020 192 5.00e-02 468 2 2 1.000 0.004 MI:hsa-miR-220 mi 1 MI:hsa-miR-220 1 P61326,O15020 193 6.23e-06 21 2 2 1.000 0.095 GO:0006607 BP 1 NLS-bearing protein import into nucleus 1 O60684,O60518 193 6.86e-06 22 2 2 1.000 0.091 GO:0008139 MF 1 nuclear localization sequence binding 1 O60684,O60518 193 1.67e-05 34 2 2 1.000 0.059 GO:0005048 MF 1 signal sequence binding 1 O60684,O60518 193 6.56e-05 67 2 2 1.000 0.030 GO:0008565 MF 1 protein transporter activity 1 O60684,O60518 193 2.01e-04 117 2 2 1.000 0.017 GO:0042277 MF 1 peptide binding 1 O60684,O60518 193 2.45e-04 129 2 2 1.000 0.016 GO:0033218 MF 1 amide binding 1 O60684,O60518 193 4.11e-04 167 2 2 1.000 0.012 GO:1902593 BP 1 single-organism nuclear import 1 O60684,O60518 193 4.11e-04 167 2 2 1.000 0.012 GO:0006606 BP 1 protein import into nucleus 1 O60684,O60518 193 4.11e-04 167 2 2 1.000 0.012 GO:0044744 BP 1 protein targeting to nucleus 1 O60684,O60518 193 5.00e-04 184 2 2 1.000 0.011 GO:0051170 BP 1 nuclear import 1 O60684,O60518 193 6.39e-04 208 2 2 1.000 0.010 GO:0017038 BP 1 protein import 1 O60684,O60518 193 7.22e-04 221 2 2 1.000 0.009 GO:0034504 BP 1 protein localization to nucleus 1 O60684,O60518 193 8.80e-04 244 2 2 1.000 0.008 GO:0005635 CC 1 nuclear envelope 1 O60684,O60518 193 1.50e-03 318 2 2 1.000 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 O60684,O60518 193 1.55e-03 324 2 2 1.000 0.006 GO:0051169 BP 1 nuclear transport 1 O60684,O60518 193 2.04e-03 13 2 1 0.500 0.077 TF:M06056_0 tf 1 Factor: ZNF99; motif: NGTTGAGGTTGM; match class: 0 1 O60684 193 2.40e-03 7 2 1 0.500 0.143 GO:0006610 BP 1 ribosomal protein import into nucleus 1 O60518 193 2.74e-03 8 2 1 0.500 0.125 GO:0000059 BP 1 protein import into nucleus, docking 1 O60518 193 3.48e-03 485 2 2 1.000 0.004 GO:0072594 BP 1 establishment of protein localization to organelle 1 O60684,O60518 193 3.51e-03 487 2 2 1.000 0.004 GO:0006605 BP 1 protein targeting 1 O60684,O60518 193 4.88e-03 574 2 2 1.000 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 O60684,O60518 193 6.28e-03 40 2 1 0.500 0.025 TF:M04232_1 tf 1 Factor: FOXC1; motif: AARTAAAYAAACA; match class: 1 1 O60684 193 6.40e-03 657 2 2 1.000 0.003 GO:0033365 BP 1 protein localization to organelle 1 O60684,O60518 193 6.42e-03 658 2 2 1.000 0.003 GO:0022892 MF 1 substrate-specific transporter activity 1 O60684,O60518 193 6.55e-03 665 2 2 1.000 0.003 GO:0031967 CC 1 organelle envelope 1 O60684,O60518 193 6.61e-03 668 2 2 1.000 0.003 GO:0031975 CC 1 envelope 1 O60684,O60518 193 7.45e-03 709 2 2 1.000 0.003 GO:0006886 BP 1 intracellular protein transport 1 O60684,O60518 193 8.34e-03 750 2 2 1.000 0.003 GO:0005215 MF 1 transporter activity 1 O60684,O60518 193 8.81e-03 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 O60684,O60518 193 8.89e-03 26 2 1 0.500 0.038 GO:0000060 BP 1 protein import into nucleus, translocation 1 O60518 193 1.35e-02 86 2 1 0.500 0.012 TF:M07434_1 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 1 1 O60684 193 1.38e-02 964 2 2 1.000 0.002 GO:0015031 BP 1 protein transport 1 O60684,O60518 193 1.79e-02 1100 2 2 1.000 0.002 GO:0045184 BP 1 establishment of protein localization 1 O60684,O60518 193 1.83e-02 1111 2 2 1.000 0.002 GO:0034613 BP 1 cellular protein localization 1 O60684,O60518 193 1.86e-02 1121 2 2 1.000 0.002 GO:0070727 BP 1 cellular macromolecule localization 1 O60684,O60518 193 2.08e-02 61 2 1 0.500 0.016 GO:0005643 CC 1 nuclear pore 1 O60684 193 2.15e-02 1583 2 2 1.000 0.001 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 O60684,O60518 193 2.22e-02 65 2 1 0.500 0.015 GO:0034399 CC 1 nuclear periphery 1 O60518 193 2.27e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 O60684,O60518 193 2.41e-02 154 2 1 0.500 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 O60684 193 2.68e-02 172 2 1 0.500 0.006 TF:M04254_1 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 1 1 O60684 193 2.76e-02 177 2 1 0.500 0.006 TF:M00694_0 tf 1 Factor: E4F1; motif: SYTACGTCAC; match class: 0 1 O60518 193 2.81e-02 1377 2 2 1.000 0.001 GO:0071702 BP 1 organic substance transport 1 O60684,O60518 193 2.88e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 O60684,O60518 193 3.31e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 O60684,O60518 193 3.33e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 O60684,O60518 193 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 O60684,O60518 193 3.64e-02 2428 2 2 1.000 0.001 TF:M02093_0 tf 1 Factor: ERR1; motif: CAAGGTCAMNN; match class: 0 1 O60684,O60518 193 3.78e-02 243 2 1 0.500 0.004 TF:M05454_0 tf 1 Factor: ZBTB3; motif: KGGTKYCAAC; match class: 0 1 O60684 193 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 O60684,O60518 193 3.88e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 O60684,O60518 193 4.01e-02 2548 2 2 1.000 0.001 TF:M00106_0 tf 1 Factor: CDP; motif: NATYGATSSS; match class: 0 1 O60684,O60518 193 4.05e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 O60684,O60518 193 4.35e-02 280 2 1 0.500 0.004 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 O60684 193 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 O60518 193 4.67e-02 301 2 1 0.500 0.003 TF:M07102_0 tf 1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 0 1 O60518 193 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 O60684 193 5.00e-02 1836 2 2 1.000 0.001 GO:0051641 BP 1 cellular localization 1 O60684,O60518 194 4.40e-07 33 4 3 0.750 0.091 GO:0031593 MF 1 polyubiquitin binding 1 P54727,Q9UMX0,Q9NRR5 194 5.66e-06 76 4 3 0.750 0.039 GO:0032434 BP 1 regulation of proteasomal ubiquitin-dependent protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.08e-05 94 4 3 0.750 0.032 GO:0043130 MF 1 ubiquitin binding 1 P54727,Q9UMX0,Q9NRR5 194 1.15e-05 96 4 3 0.750 0.031 GO:0061136 BP 1 regulation of proteasomal protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.51e-05 105 4 3 0.750 0.029 GO:0032182 MF 1 ubiquitin-like protein binding 1 P54727,Q9UMX0,Q9NRR5 194 7.26e-05 177 4 3 0.750 0.017 GO:1903050 BP 1 regulation of proteolysis involved in cellular protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 9.13e-05 191 4 3 0.750 0.016 GO:1903362 BP 1 regulation of cellular protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.39e-04 25 4 2 0.500 0.080 GO:0097352 BP 1 autophagosome maturation 1 Q9UMX0,Q9NRR5 194 1.63e-04 27 4 2 0.500 0.074 GO:0097576 BP 1 vacuole fusion 1 Q9UMX0,Q9NRR5 194 1.80e-04 152 4 3 0.750 0.020 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 P54727,Q9UMX0,Q9NRR5 194 2.49e-04 267 4 3 0.750 0.011 GO:0042176 BP 1 regulation of protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 2.63e-04 272 4 3 0.750 0.011 GO:0031329 BP 1 regulation of cellular catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 3.78e-04 307 4 3 0.750 0.010 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 4.49e-04 325 4 3 0.750 0.009 GO:0010498 BP 1 proteasomal protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 5.60e-04 350 4 3 0.750 0.009 GO:0009894 BP 1 regulation of catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 5.68e-04 50 4 2 0.500 0.040 GO:0005776 CC 1 autophagosome 1 Q9UMX0,Q9NRR5 194 8.59e-04 404 4 3 0.750 0.007 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 8.84e-04 408 4 3 0.750 0.007 GO:0019941 BP 1 modification-dependent protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 9.37e-04 416 4 3 0.750 0.007 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 9.44e-04 417 4 3 0.750 0.007 GO:0030162 BP 1 regulation of proteolysis 1 P54727,Q9UMX0,Q9NRR5 194 1.26e-03 459 4 3 0.750 0.007 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.47e-03 484 4 3 0.750 0.006 GO:0044257 BP 1 cellular protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.79e-03 1 4 1 0.250 1.000 GO:0004617 MF 1 phosphoglycerate dehydrogenase activity 1 O43175 194 1.79e-03 1 4 1 0.250 1.000 GO:1901340 BP 1 negative regulation of store-operated calcium channel activity 1 Q9UMX0 194 2.27e-03 560 4 3 0.750 0.005 GO:0030163 BP 1 protein catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 3.85e-03 130 4 2 0.500 0.015 GO:0007033 BP 1 vacuole organization 1 Q9UMX0,Q9NRR5 194 4.85e-03 146 4 2 0.500 0.014 GO:0048284 BP 1 organelle fusion 1 Q9UMX0,Q9NRR5 194 4.91e-03 727 4 3 0.750 0.004 GO:0044265 BP 1 cellular macromolecule catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 5.37e-03 3 4 1 0.250 0.333 GO:0006564 BP 1 L-serine biosynthetic process 1 O43175 194 5.37e-03 3 4 1 0.250 0.333 GO:0071942 CC 1 XPC complex 1 P54727 194 5.37e-03 3 4 1 0.250 0.333 GO:1901097 BP 1 negative regulation of autophagosome maturation 1 Q9NRR5 194 7.17e-03 4 4 1 0.250 0.250 GO:1901339 BP 1 regulation of store-operated calcium channel activity 1 Q9UMX0 194 8.51e-03 876 4 3 0.750 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 8.96e-03 5 4 1 0.250 0.200 GO:0035973 BP 1 aggrephagy 1 Q9UMX0 194 9.34e-03 203 4 2 0.500 0.010 GO:0016236 BP 1 macroautophagy 1 Q9UMX0,Q9NRR5 194 1.04e-02 937 4 3 0.750 0.003 GO:0006508 BP 1 proteolysis 1 P54727,Q9UMX0,Q9NRR5 194 1.07e-02 6 4 1 0.250 0.167 GO:1901096 BP 1 regulation of autophagosome maturation 1 Q9NRR5 194 1.25e-02 2 4 1 0.250 0.500 TF:M06885_0 tf 1 Factor: ZNF545; motif: GGGGGARTTRGGGTCWGY; match class: 0 1 Q9UMX0 194 1.25e-02 7 4 1 0.250 0.143 GO:1903071 BP 1 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 1 Q9UMX0 194 1.43e-02 8 4 1 0.250 0.125 GO:0031595 CC 1 nuclear proteasome complex 1 Q9NRR5 194 1.43e-02 8 4 1 0.250 0.125 GO:0006563 BP 1 L-serine metabolic process 1 O43175 194 1.61e-02 9 4 1 0.250 0.111 GO:0031597 CC 1 cytosolic proteasome complex 1 Q9NRR5 194 1.61e-02 9 4 1 0.250 0.111 GO:1903069 BP 1 regulation of ER-associated ubiquitin-dependent protein catabolic process 1 Q9UMX0 194 1.82e-02 159 4 2 0.500 0.013 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 O43175,Q9UMX0 194 1.85e-02 1141 4 3 0.750 0.003 GO:0044248 BP 1 cellular catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 1.97e-02 11 4 1 0.250 0.091 GO:0009070 BP 1 serine family amino acid biosynthetic process 1 O43175 194 2.12e-02 834 4 3 0.750 0.004 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 O43175,P54727,Q9NRR5 194 2.15e-02 12 4 1 0.250 0.083 GO:1904294 BP 1 positive regulation of ERAD pathway 1 Q9UMX0 194 2.28e-02 505 4 3 0.750 0.006 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 O43175,P54727,Q9UMX0 194 2.50e-02 1 4 1 0.250 1.000 OMIM:601815 omi 1 PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY; PHGDHD;;PHGDH DEFICIENCY 1 O43175 194 2.50e-02 2 4 1 0.250 0.500 HP:0011226 hp 1 Aplasia/Hypoplasia of the eyelid 1 O43175 194 2.50e-02 2 4 1 0.250 0.500 HP:0007525 hp 1 Yellow subcutaneous tissue covered by thin, scaly skin 1 O43175 194 2.50e-02 2 4 1 0.250 0.500 HP:0011224 hp 1 Ablepharon 1 O43175 194 2.50e-02 14 4 1 0.250 0.071 GO:0000109 CC 1 nucleotide-excision repair complex 1 P54727 194 2.58e-02 340 4 2 0.500 0.006 GO:0006914 BP 1 autophagy 1 Q9UMX0,Q9NRR5 194 2.64e-02 1290 4 3 0.750 0.002 GO:1901575 BP 1 organic substance catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 2.68e-02 15 4 1 0.250 0.067 GO:0016242 BP 1 negative regulation of macroautophagy 1 Q9NRR5 194 2.68e-02 15 4 1 0.250 0.067 GO:1903170 BP 1 negative regulation of calcium ion transmembrane transport 1 Q9UMX0 194 2.68e-02 15 4 1 0.250 0.067 GO:1901020 BP 1 negative regulation of calcium ion transmembrane transporter activity 1 Q9UMX0 194 2.86e-02 16 4 1 0.250 0.062 GO:2001258 BP 1 negative regulation of cation channel activity 1 Q9UMX0 194 2.95e-02 932 4 3 0.750 0.003 TF:M05432_1 tf 1 Factor: ZSCAN18; motif: TRRCGRCGNMCC; match class: 1 1 O43175,P54727,Q9UMX0 194 2.97e-02 1342 4 3 0.750 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 P54727,Q9UMX0,Q9NRR5 194 3.10e-02 1362 4 3 0.750 0.002 GO:0009056 BP 1 catabolic process 1 P54727,Q9UMX0,Q9NRR5 194 3.13e-02 5 4 1 0.250 0.200 TF:M06039_0 tf 1 Factor: ZNF878; motif: NCCACGTGGTCC; match class: 0 1 O43175 194 3.22e-02 567 4 3 0.750 0.005 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 O43175,P54727,Q9UMX0 194 3.45e-02 394 4 2 0.500 0.005 GO:0005773 CC 1 vacuole 1 Q9UMX0,Q9NRR5 194 3.65e-02 1442 4 3 0.750 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 P54727,Q9UMX0,Q9NRR5 194 3.75e-02 3 4 1 0.250 0.333 HP:0011451 hp 1 Congenital microcephaly 1 O43175 194 3.75e-02 21 4 1 0.250 0.048 GO:0000717 BP 1 nucleotide-excision repair, DNA duplex unwinding 1 P54727 194 3.75e-02 21 4 1 0.250 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 Q9UMX0 194 3.93e-02 22 4 1 0.250 0.045 GO:1902175 BP 1 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 Q9UMX0 194 3.93e-02 22 4 1 0.250 0.045 GO:0000715 BP 1 nucleotide-excision repair, DNA damage recognition 1 P54727 194 4.29e-02 24 4 1 0.250 0.042 GO:1904292 BP 1 regulation of ERAD pathway 1 Q9UMX0 194 4.29e-02 625 4 3 0.750 0.005 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 O43175,P54727,Q9UMX0 194 4.48e-02 634 4 3 0.750 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 O43175,P54727,Q9UMX0 194 4.58e-02 639 4 3 0.750 0.005 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 O43175,P54727,Q9UMX0 194 4.82e-02 27 4 1 0.250 0.037 GO:0016235 CC 1 aggresome 1 Q9UMX0 194 5.00e-02 6 4 1 0.250 0.167 CORUM:5209 cor 1 Ubiquilin-proteasome complex 1 Q9UMX0 194 5.00e-02 28 4 1 0.250 0.036 GO:0006294 BP 1 nucleotide-excision repair, preincision complex assembly 1 P54727 194 5.00e-02 6 4 1 0.250 0.167 REAC:977347 rea 1 Serine biosynthesis 1 O43175 194 5.00e-02 2 4 1 0.250 0.500 OMIM:256520 omi 1 Neu-Laxova Syndrome 1 O43175 194 5.00e-02 37 4 1 0.250 0.027 KEGG:00260 keg 1 Glycine, serine and threonine metabolism 1 O43175 194 5.00e-02 658 4 3 0.750 0.005 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 O43175,P54727,Q9UMX0 194 5.00e-02 4 4 1 0.250 0.250 HP:0002190 hp 1 Choroid plexus cyst 1 O43175 194 5.00e-02 4 4 1 0.250 0.250 HP:0007266 hp 1 Cerebral dysmyelination 1 O43175 194 5.00e-02 28 4 1 0.250 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 Q9UMX0 195 8.62e-20 18 8 7 0.875 0.389 GO:0042776 BP 1 mitochondrial ATP synthesis coupled proton transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.36e-19 19 8 7 0.875 0.368 GO:0045259 CC 1 proton-transporting ATP synthase complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.36e-19 19 8 7 0.875 0.368 GO:0005753 CC 1 mitochondrial proton-transporting ATP synthase complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.64e-19 23 8 7 0.875 0.304 GO:0015986 BP 1 ATP synthesis coupled proton transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.64e-19 23 8 7 0.875 0.304 GO:0015985 BP 1 energy coupled proton transport, down electrochemical gradient 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.02e-18 16 8 7 0.875 0.438 REAC:163210 rea 1 Formation of ATP by chemiosmotic coupling 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.16e-17 33 8 7 0.875 0.212 GO:1902600 BP 1 hydrogen ion transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.46e-17 34 8 7 0.875 0.206 GO:0016469 CC 1 proton-transporting two-sector ATPase complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.82e-17 35 8 7 0.875 0.200 GO:0006754 BP 1 ATP biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.78e-17 37 8 7 0.875 0.189 GO:0009206 BP 1 purine ribonucleoside triphosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.78e-17 37 8 7 0.875 0.189 GO:0009145 BP 1 purine nucleoside triphosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.41e-17 38 8 7 0.875 0.184 GO:0009201 BP 1 ribonucleoside triphosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.70e-16 50 8 7 0.875 0.140 GO:0009142 BP 1 nucleoside triphosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.13e-16 51 8 7 0.875 0.137 GO:0009168 BP 1 purine ribonucleoside monophosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.13e-16 51 8 7 0.875 0.137 GO:0009127 BP 1 purine nucleoside monophosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.16e-16 53 8 7 0.875 0.132 GO:0009156 BP 1 ribonucleoside monophosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.16e-16 53 8 7 0.875 0.132 GO:0015992 BP 1 proton transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.48e-16 55 8 7 0.875 0.127 GO:0009124 BP 1 nucleoside monophosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.48e-16 55 8 7 0.875 0.127 GO:0006818 BP 1 hydrogen transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.12e-16 58 8 7 0.875 0.121 GO:0046129 BP 1 purine ribonucleoside biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.12e-16 58 8 7 0.875 0.121 GO:0042451 BP 1 purine nucleoside biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.18e-15 61 8 7 0.875 0.115 GO:1990542 BP 1 mitochondrial transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.88e-15 65 8 7 0.875 0.108 GO:0042455 BP 1 ribonucleoside biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.12e-14 83 8 7 0.875 0.084 GO:0009163 BP 1 nucleoside biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.33e-14 85 8 7 0.875 0.082 GO:1901659 BP 1 glycosyl compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.76e-14 94 8 7 0.875 0.074 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 9.14e-14 111 8 7 0.875 0.063 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 9.14e-14 111 8 7 0.875 0.063 GO:0098798 CC 1 mitochondrial protein complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.11e-13 114 8 7 0.875 0.061 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.18e-13 115 8 7 0.875 0.061 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.25e-13 116 8 7 0.875 0.060 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.54e-13 128 8 7 0.875 0.055 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.52e-13 134 8 7 0.875 0.052 GO:0009165 BP 1 nucleotide biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.61e-13 143 8 7 0.875 0.049 GO:0044455 CC 1 mitochondrial membrane part 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.17e-13 148 8 7 0.875 0.047 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.67e-12 178 8 7 0.875 0.039 GO:0046034 BP 1 ATP metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.82e-12 110 8 7 0.875 0.064 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.08e-12 189 8 7 0.875 0.037 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.24e-12 190 8 7 0.875 0.037 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.74e-12 193 8 7 0.875 0.036 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.32e-12 201 8 7 0.875 0.035 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.32e-12 201 8 7 0.875 0.035 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.32e-12 201 8 7 0.875 0.035 GO:0015672 BP 1 monovalent inorganic cation transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.78e-12 203 8 7 0.875 0.034 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.52e-12 206 8 7 0.875 0.034 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.62e-12 210 8 7 0.875 0.033 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.16e-11 219 8 7 0.875 0.032 GO:0006839 BP 1 mitochondrial transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.39e-11 109 8 7 0.875 0.064 KEGG:00190 keg 1 Oxidative phosphorylation 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.22e-11 240 8 7 0.875 0.029 GO:0098662 BP 1 inorganic cation transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.22e-11 240 8 7 0.875 0.029 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.42e-11 243 8 7 0.875 0.029 GO:0042278 BP 1 purine nucleoside metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.98e-11 153 8 7 0.875 0.046 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.05e-11 251 8 7 0.875 0.028 GO:0009119 BP 1 ribonucleoside metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.31e-11 254 8 7 0.875 0.028 GO:0098655 BP 1 cation transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.97e-11 269 8 7 0.875 0.026 GO:0098660 BP 1 inorganic ion transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.76e-11 281 8 7 0.875 0.025 GO:0009116 BP 1 nucleoside metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.05e-10 299 8 7 0.875 0.023 GO:1901657 BP 1 glycosyl compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.12e-10 302 8 7 0.875 0.023 GO:0005743 CC 1 mitochondrial inner membrane 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.15e-10 303 8 7 0.875 0.023 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.26e-10 307 8 7 0.875 0.023 GO:0009259 BP 1 ribonucleotide metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.65e-10 319 8 7 0.875 0.022 GO:0019693 BP 1 ribose phosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.84e-10 324 8 7 0.875 0.022 GO:0006163 BP 1 purine nucleotide metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.88e-10 325 8 7 0.875 0.022 GO:0019866 CC 1 organelle inner membrane 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.28e-10 334 8 7 0.875 0.021 GO:0090407 BP 1 organophosphate biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.36e-10 15 8 4 0.500 0.267 GO:0044769 MF 1 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1 P30049,P06576,P24539,O75947 195 2.38e-10 674 8 8 1.000 0.012 GO:0044429 CC 1 mitochondrial part 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.17e-10 350 8 7 0.875 0.020 GO:0072521 BP 1 purine-containing compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.44e-10 354 8 7 0.875 0.020 GO:0016887 MF 1 ATPase activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.55e-10 388 8 7 0.875 0.018 GO:0009117 BP 1 nucleotide metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.83e-10 398 8 7 0.875 0.018 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.97e-10 399 8 7 0.875 0.018 GO:0031966 CC 1 mitochondrial membrane 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.07e-09 416 8 7 0.875 0.017 GO:0034220 BP 1 ion transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.44e-09 434 8 7 0.875 0.016 GO:0005740 CC 1 mitochondrial envelope 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.55e-09 851 8 8 1.000 0.009 GO:0044711 BP 1 single-organism biosynthetic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.58e-09 440 8 7 0.875 0.016 GO:0006812 BP 1 cation transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.69e-09 444 8 7 0.875 0.016 GO:0098796 CC 1 membrane protein complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.85e-09 450 8 7 0.875 0.016 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.37e-09 466 8 7 0.875 0.015 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.76e-09 529 8 7 0.875 0.013 GO:0055085 BP 1 transmembrane transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.13e-09 1029 8 8 1.000 0.008 GO:0005739 CC 1 mitochondrion 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.85e-09 553 8 7 0.875 0.013 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.98e-09 6 8 3 0.375 0.500 GO:0046933 MF 1 proton-transporting ATP synthase activity, rotational mechanism 1 P30049,P24539,O75947 195 1.02e-08 574 8 7 0.875 0.012 GO:1902582 BP 1 single-organism intracellular transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.08e-08 579 8 7 0.875 0.012 GO:0022857 MF 1 transmembrane transporter activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.23e-08 590 8 7 0.875 0.012 GO:0016462 MF 1 pyrophosphatase activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.26e-08 592 8 7 0.875 0.012 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.26e-08 592 8 7 0.875 0.012 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.92e-08 42 8 4 0.500 0.095 GO:0019829 MF 1 cation-transporting ATPase activity 1 P30049,P06576,P24539,O75947 195 2.85e-08 665 8 7 0.875 0.011 GO:0031967 CC 1 organelle envelope 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.94e-08 668 8 7 0.875 0.010 GO:0031975 CC 1 envelope 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.13e-08 674 8 7 0.875 0.010 GO:0019637 BP 1 organophosphate metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.00e-08 53 8 4 0.500 0.075 GO:0015078 MF 1 hydrogen ion transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 5.40e-08 54 8 4 0.500 0.074 GO:0042625 MF 1 ATPase coupled ion transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 5.62e-08 733 8 7 0.875 0.010 GO:0006811 BP 1 ion transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.69e-08 1333 8 8 1.000 0.006 GO:0044281 BP 1 small molecule metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.59e-08 750 8 7 0.875 0.009 GO:0005215 MF 1 transporter activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.99e-08 771 8 7 0.875 0.009 GO:1902580 BP 1 single-organism cellular localization 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.01e-07 798 8 7 0.875 0.009 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.30e-07 77 8 4 0.500 0.052 GO:0022853 MF 1 active ion transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 2.55e-07 79 8 4 0.500 0.051 GO:0016820 MF 1 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1 P30049,P06576,P24539,O75947 195 2.55e-07 79 8 4 0.500 0.051 GO:0042626 MF 1 ATPase activity, coupled to transmembrane movement of substances 1 P30049,P06576,P24539,O75947 195 3.11e-07 83 8 4 0.500 0.048 GO:0015405 MF 1 P-P-bond-hydrolysis-driven transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 3.11e-07 83 8 4 0.500 0.048 GO:0015399 MF 1 primary active transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 3.35e-07 118 8 5 0.625 0.042 KEGG:05012 keg 1 Parkinson's disease 1 P30049,P06576,P24539,O75947,P48047 195 3.80e-07 965 8 7 0.875 0.007 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.15e-07 94 8 4 0.500 0.043 GO:0043492 MF 1 ATPase activity, coupled to movement of substances 1 P30049,P06576,P24539,O75947 195 9.10e-07 144 8 5 0.625 0.035 KEGG:05010 keg 1 Alzheimer's disease 1 P30049,P06576,P24539,O75947,P48047 195 1.85e-06 166 8 5 0.625 0.030 KEGG:05016 keg 1 Huntington's disease 1 P30049,P06576,P24539,O75947,P48047 195 2.13e-06 1237 8 7 0.875 0.006 GO:0046907 BP 1 intracellular transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.30e-06 3 8 2 0.250 0.667 GO:0000276 CC 1 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 1 P24539,O75947 195 2.30e-06 3 8 2 0.250 0.667 GO:0045263 CC 1 proton-transporting ATP synthase complex, coupling factor F(o) 1 P24539,O75947 195 3.31e-06 1048 8 8 1.000 0.008 KEGG:01100 keg 1 Metabolic pathways 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.60e-06 4 8 2 0.250 0.500 GO:0045261 CC 1 proton-transporting ATP synthase complex, catalytic core F(1) 1 P30049,P06576 195 4.60e-06 4 8 2 0.250 0.500 GO:0033177 CC 1 proton-transporting two-sector ATPase complex, proton-transporting domain 1 P24539,O75947 195 4.60e-06 4 8 2 0.250 0.500 GO:0000275 CC 1 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) 1 P30049,P06576 195 5.35e-06 1414 8 7 0.875 0.005 GO:0031090 CC 1 organelle membrane 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.67e-06 5 8 2 0.250 0.400 GO:0033178 CC 1 proton-transporting two-sector ATPase complex, catalytic domain 1 P30049,P06576 195 7.78e-06 1493 8 7 0.875 0.005 GO:0051649 BP 1 establishment of localization in cell 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.96e-06 1498 8 7 0.875 0.005 GO:0044765 BP 1 single-organism transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.12e-06 187 8 4 0.500 0.021 GO:0022804 MF 1 active transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 8.32e-06 1369 8 7 0.875 0.005 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 9.02e-06 192 8 4 0.500 0.021 GO:0015077 MF 1 monovalent inorganic cation transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 1.06e-05 2560 8 8 1.000 0.003 GO:0044710 BP 1 single-organism metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.08e-05 1565 8 7 0.875 0.004 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.29e-05 1607 8 7 0.875 0.004 GO:0016787 MF 1 hydrolase activity 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.56e-05 1652 8 7 0.875 0.004 GO:1902578 BP 1 single-organism localization 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.84e-05 476 8 5 0.625 0.011 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P49748,P06576,O75947,P56385,P48047 195 2.30e-05 1718 8 8 1.000 0.005 REAC:1430728 rea 1 Metabolism 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.19e-05 264 8 4 0.500 0.015 GO:0042623 MF 1 ATPase activity, coupled 1 P30049,P06576,P24539,O75947 195 3.22e-05 1836 8 7 0.875 0.004 GO:0051641 BP 1 cellular localization 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.23e-05 995 8 6 0.750 0.006 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.41e-05 1851 8 7 0.875 0.004 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.42e-05 1923 8 7 0.875 0.004 GO:0006793 BP 1 phosphorus metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.63e-05 305 8 4 0.500 0.013 GO:0022890 MF 1 inorganic cation transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 7.96e-05 2096 8 7 0.875 0.003 GO:0043234 CC 1 protein complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 9.03e-05 344 8 4 0.500 0.012 GO:0005759 CC 1 mitochondrial matrix 1 P49748,P30049,P06576,P24539 195 1.13e-04 364 8 4 0.500 0.011 GO:0008324 MF 1 cation transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 1.30e-04 3499 8 8 1.000 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.36e-04 2267 8 7 0.875 0.003 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.52e-04 2305 8 7 0.875 0.003 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.52e-04 3569 8 8 1.000 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.54e-04 2310 8 7 0.875 0.003 GO:0018130 BP 1 heterocycle biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.71e-04 3620 8 8 1.000 0.002 GO:0009058 BP 1 biosynthetic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.74e-04 1329 8 6 0.750 0.005 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.86e-04 2374 8 7 0.875 0.003 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.95e-04 3681 8 8 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.07e-04 2412 8 7 0.875 0.003 GO:0044425 CC 1 membrane part 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.27e-04 798 8 5 0.625 0.006 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 3.19e-04 1477 8 6 0.750 0.004 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.23e-04 1480 8 6 0.750 0.004 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.78e-04 1521 8 6 0.750 0.004 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.86e-04 2644 8 7 0.875 0.003 GO:0006810 BP 1 transport 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.87e-04 500 8 4 0.500 0.008 GO:0015075 MF 1 ion transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 3.94e-04 4019 8 8 1.000 0.002 GO:0003824 MF 1 catalytic activity 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.52e-04 2707 8 7 0.875 0.003 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.63e-04 1576 8 6 0.750 0.004 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.85e-04 1589 8 6 0.750 0.004 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.00e-04 2748 8 7 0.875 0.003 GO:0051234 BP 1 establishment of localization 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.07e-04 536 8 4 0.500 0.007 GO:0022891 MF 1 substrate-specific transmembrane transporter activity 1 P30049,P06576,P24539,O75947 195 5.40e-04 1619 8 6 0.750 0.004 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.46e-04 1622 8 6 0.750 0.004 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.62e-04 39 8 2 0.250 0.051 GO:0042645 CC 1 mitochondrial nucleoid 1 P49748,P06576 195 5.99e-04 977 8 5 0.625 0.005 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P06576,P24539,O75947,P56385,P48047 195 6.21e-04 41 8 2 0.250 0.049 GO:0009295 CC 1 nucleoid 1 P49748,P06576 195 6.51e-04 994 8 5 0.625 0.005 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P49748,P06576,O75947,P56385,P48047 195 8.59e-04 1756 8 6 0.750 0.003 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 8.84e-04 1765 8 6 0.750 0.003 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 8.95e-04 1769 8 6 0.750 0.003 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 9.33e-04 1782 8 6 0.750 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 9.51e-04 1788 8 6 0.750 0.003 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 9.79e-04 1797 8 6 0.750 0.003 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 9.97e-04 1803 8 6 0.750 0.003 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.03e-03 257 8 3 0.375 0.012 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P49748,P30049,P06576 195 1.05e-03 1818 8 6 0.750 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.05e-03 1820 8 6 0.750 0.003 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.11e-03 658 8 4 0.500 0.006 GO:0022892 MF 1 substrate-specific transporter activity 1 P30049,P06576,P24539,O75947 195 1.15e-03 1121 8 5 0.625 0.004 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P49748,P06576,O75947,P56385,P48047 195 1.20e-03 1863 8 6 0.750 0.003 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.26e-03 2 8 1 0.125 0.500 TF:M06569_1 tf 1 Factor: ZNF775; motif: NYGGGAAAATW; match class: 1 1 O75947 195 1.26e-03 1 8 1 0.125 1.000 GO:0005754 CC 1 mitochondrial proton-transporting ATP synthase, catalytic core 1 P06576 195 1.26e-03 1 8 1 0.125 1.000 GO:0045267 CC 1 proton-transporting ATP synthase, catalytic core 1 P06576 195 1.26e-03 1 8 1 0.125 1.000 GO:0000274 CC 1 mitochondrial proton-transporting ATP synthase, stator stalk 1 O75947 195 1.26e-03 1 8 1 0.125 1.000 GO:0045265 CC 1 proton-transporting ATP synthase, stator stalk 1 O75947 195 1.28e-03 1883 8 6 0.750 0.003 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.28e-03 1885 8 6 0.750 0.003 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.30e-03 2875 8 7 0.875 0.002 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 P49748,P06576,P24539,O75964,O75947,P56385,P48047 195 1.38e-03 1909 8 6 0.750 0.003 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.44e-03 1924 8 6 0.750 0.003 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.48e-03 1932 8 6 0.750 0.003 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.48e-03 1932 8 6 0.750 0.003 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.48e-03 1933 8 6 0.750 0.003 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.67e-03 1974 8 6 0.750 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.70e-03 4399 8 8 1.000 0.002 HPA:021020_02 hpa 1 liver; hepatocytes[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.71e-03 1984 8 6 0.750 0.003 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 P30049,P24539,O75964,O75947,P56385,P48047 195 1.72e-03 653 8 4 0.500 0.006 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P49748,P24539,O75947,P56385 195 1.74e-03 1989 8 6 0.750 0.003 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.77e-03 1996 8 6 0.750 0.003 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.80e-03 3017 8 7 0.875 0.002 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 1.93e-03 2026 8 6 0.750 0.003 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.94e-03 985 8 4 0.500 0.004 TF:M02102_1 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 1 P30049,O75964,P56385,P48047 195 2.00e-03 2039 8 6 0.750 0.003 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.02e-03 2043 8 6 0.750 0.003 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.05e-03 2049 8 6 0.750 0.003 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.07e-03 2051 8 6 0.750 0.003 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.09e-03 2055 8 6 0.750 0.003 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.09e-03 3401 8 7 0.875 0.002 GO:0051179 BP 1 localization 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.12e-03 2060 8 6 0.750 0.003 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.15e-03 3415 8 7 0.875 0.002 GO:0032991 CC 1 macromolecular complex 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.18e-03 2071 8 6 0.750 0.003 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.19e-03 2072 8 6 0.750 0.003 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.27e-03 3443 8 7 0.875 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.27e-03 2086 8 6 0.750 0.003 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.31e-03 2092 8 6 0.750 0.003 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.38e-03 1308 8 5 0.625 0.004 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 2.39e-03 1310 8 5 0.625 0.004 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 P30049,O75964,O75947,P56385,P48047 195 2.42e-03 2110 8 6 0.750 0.003 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.48e-03 2119 8 6 0.750 0.003 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.51e-03 4 8 1 0.125 0.250 TF:M06207_0 tf 1 Factor: ZNF271; motif: NGSTGCGAAAGM; match class: 0 1 P56385 195 2.55e-03 2130 8 6 0.750 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.61e-03 2139 8 6 0.750 0.003 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.61e-03 2139 8 6 0.750 0.003 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.70e-03 4659 8 8 1.000 0.002 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.70e-03 2151 8 6 0.750 0.003 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.71e-03 2153 8 6 0.750 0.003 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.75e-03 2159 8 6 0.750 0.003 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.80e-03 3554 8 7 0.875 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.80e-03 4682 8 8 1.000 0.002 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.82e-03 2168 8 6 0.750 0.003 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.84e-03 3561 8 7 0.875 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.85e-03 1360 8 5 0.625 0.004 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 2.88e-03 2176 8 6 0.750 0.003 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.93e-03 2183 8 6 0.750 0.003 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.97e-03 2188 8 6 0.750 0.003 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.99e-03 2191 8 6 0.750 0.003 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.04e-03 2197 8 6 0.750 0.003 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.07e-03 3269 8 7 0.875 0.002 HPA:010010_03 hpa 1 duodenum; glandular cells[Uncertain,High] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 3.08e-03 2202 8 6 0.750 0.003 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.13e-03 2209 8 6 0.750 0.003 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.18e-03 2215 8 6 0.750 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.20e-03 455 8 3 0.375 0.007 MI:hsa-miR-198 mi 1 MI:hsa-miR-198 1 P06576,O75947,P56385 195 3.28e-03 2227 8 6 0.750 0.003 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.28e-03 2227 8 6 0.750 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.28e-03 775 8 4 0.500 0.005 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P24539,O75947,P56385,P48047 195 3.30e-03 1403 8 5 0.625 0.004 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 P49748,P06576,P24539,O75947,P56385 195 3.64e-03 2270 8 6 0.750 0.003 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.65e-03 2271 8 6 0.750 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.66e-03 798 8 4 0.500 0.005 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 3.68e-03 2274 8 6 0.750 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.68e-03 2274 8 6 0.750 0.003 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.70e-03 2276 8 6 0.750 0.003 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.73e-03 2279 8 6 0.750 0.003 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.74e-03 2281 8 6 0.750 0.003 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.79e-03 2286 8 6 0.750 0.003 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.79e-03 3 8 1 0.125 0.333 GO:0017099 MF 1 very-long-chain-acyl-CoA dehydrogenase activity 1 P49748 195 3.83e-03 2290 8 6 0.750 0.003 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.87e-03 2295 8 6 0.750 0.003 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.88e-03 1453 8 5 0.625 0.003 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 3.93e-03 2049 8 5 0.625 0.002 TF:M01876_0 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 0 1 P49748,P06576,P24539,O75964,P48047 195 4.00e-03 2308 8 6 0.750 0.003 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.02e-03 2310 8 6 0.750 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.19e-03 2328 8 6 0.750 0.003 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.34e-03 2342 8 6 0.750 0.003 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.38e-03 1492 8 5 0.625 0.003 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 4.59e-03 2366 8 6 0.750 0.003 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.59e-03 375 8 3 0.375 0.008 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P06576,O75947,P56385 195 4.80e-03 2385 8 6 0.750 0.003 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.91e-03 2395 8 6 0.750 0.003 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 4.93e-03 2397 8 6 0.750 0.003 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.02e-03 8 8 1 0.125 0.125 TF:M04102_0 tf 1 Factor: RFX5; motif: NGTTRCCATRGCAACN; match class: 0 1 P49748 195 5.05e-03 4 8 1 0.125 0.250 GO:0042760 BP 1 very long-chain fatty acid catabolic process 1 P49748 195 5.05e-03 4 8 1 0.125 0.250 GO:0004466 MF 1 long-chain-acyl-CoA dehydrogenase activity 1 P49748 195 5.16e-03 2417 8 6 0.750 0.002 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.26e-03 393 8 3 0.375 0.008 HPA:041020_13 hpa 1 spleen; cells in white pulp[Supportive,High] 1 O75947,P56385,P48047 195 5.26e-03 2425 8 6 0.750 0.002 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.31e-03 2429 8 6 0.750 0.002 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.38e-03 2435 8 6 0.750 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.61e-03 3948 8 7 0.875 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.61e-03 1574 8 5 0.625 0.003 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 5.62e-03 2454 8 6 0.750 0.002 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.64e-03 2456 8 6 0.750 0.002 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.67e-03 2458 8 6 0.750 0.002 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.81e-03 2469 8 6 0.750 0.002 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.85e-03 2472 8 6 0.750 0.002 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 5.85e-03 5629 8 8 1.000 0.001 GO:0044444 CC 1 cytoplasmic part 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.85e-03 408 8 3 0.375 0.007 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 O75947,P56385,P48047 195 5.86e-03 1589 8 5 0.625 0.003 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 5.91e-03 2477 8 6 0.750 0.002 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 6.13e-03 5162 8 8 1.000 0.002 HPA:017010_02 hpa 1 heart muscle; myocytes[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 6.15e-03 2495 8 6 0.750 0.002 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 6.17e-03 2496 8 6 0.750 0.002 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 6.21e-03 919 8 4 0.500 0.004 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 6.26e-03 921 8 4 0.500 0.004 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P49748,O75947,P56385,P48047 195 6.29e-03 2505 8 6 0.750 0.002 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 6.44e-03 1622 8 5 0.625 0.003 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 6.46e-03 1623 8 5 0.625 0.003 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 6.89e-03 2547 8 6 0.750 0.002 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 7.30e-03 5787 8 8 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.30e-03 2574 8 6 0.750 0.002 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 7.50e-03 3741 8 7 0.875 0.002 HPA:039020 hpa 1 soft tissue 1; chondrocytes 1 P49748,P30049,P06576,P24539,O75964,O75947,P48047 195 7.52e-03 12 8 1 0.125 0.083 TF:M06118_0 tf 1 Factor: ZNF23; motif: NGGTAAWGGTTN; match class: 0 1 P49748 195 7.52e-03 3743 8 7 0.875 0.002 HPA:006020_02 hpa 1 cerebellum; cells in granular layer[Uncertain,Medium] 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 7.56e-03 3 8 1 0.125 0.333 REAC:77305 rea 1 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1 P49748 195 7.58e-03 6 8 1 0.125 0.167 GO:0046688 BP 1 response to copper ion 1 P30049 195 7.58e-03 6 8 1 0.125 0.167 GO:0046322 BP 1 negative regulation of fatty acid oxidation 1 P49748 195 7.59e-03 2372 8 5 0.625 0.002 TF:M04627_0 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 0 1 P49748,P30049,O75964,P56385,P48047 195 7.68e-03 705 8 3 0.375 0.004 TF:M07052_1 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 1 P30049,O75964,P56385 195 8.06e-03 1704 8 5 0.625 0.003 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 8.13e-03 1707 8 5 0.625 0.003 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 8.26e-03 5877 8 8 1.000 0.001 GO:0044422 CC 1 organelle part 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.46e-03 1722 8 5 0.625 0.003 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P49748,P30049,P24539,O75947,P56385 195 8.61e-03 5386 8 8 1.000 0.001 HPA:032010_02 hpa 1 salivary gland; glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 8.77e-03 14 8 1 0.125 0.071 TF:M06121_0 tf 1 Factor: ZNF22; motif: NTGTNAAAAAGM; match class: 0 1 P48047 195 9.13e-03 750 8 3 0.375 0.004 TF:M03821_1 tf 1 Factor: ER-beta; motif: ANNSTGACCYRGNN; match class: 1 1 P30049,O75947,P56385 195 9.29e-03 4264 8 7 0.875 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 9.80e-03 248 8 2 0.250 0.008 TF:M05317_0 tf 1 Factor: sox30; motif: YAAATTTTCN; match class: 0 1 P49748,P48047 195 9.95e-03 250 8 2 0.250 0.008 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 P06576,P24539 195 9.97e-03 3907 8 7 0.875 0.002 HPA:012010_01 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Low] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 1.00e-02 1787 8 5 0.625 0.003 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 1.01e-02 8 8 1 0.125 0.125 GO:0042288 MF 1 MHC class I protein binding 1 P06576 195 1.03e-02 784 8 3 0.375 0.004 TF:M00426_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 P06576,P56385,P48047 195 1.04e-02 5512 8 8 1.000 0.001 HPA:002020_01 hpa 1 appendix; lymphoid tissue[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.04e-02 1802 8 5 0.625 0.003 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385 195 1.05e-02 788 8 3 0.375 0.004 TF:M00431_1 tf 1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 1 P30049,O75964,P56385 195 1.06e-02 17 8 1 0.125 0.059 TF:M06362_0 tf 1 Factor: ZNF730; motif: KGGGACWAAAGM; match class: 0 1 P06576 195 1.06e-02 17 8 1 0.125 0.059 TF:M07126_1 tf 1 Factor: Smad2:Smad3:Smad4; motif: NTGTCTGNCACCT; match class: 1 1 P56385 195 1.10e-02 1825 8 5 0.625 0.003 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 1.12e-02 1078 8 4 0.500 0.004 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P49748,O75947,P56385,P48047 195 1.14e-02 9 8 1 0.125 0.111 GO:0045717 BP 1 negative regulation of fatty acid biosynthetic process 1 P49748 195 1.15e-02 6128 8 8 1.000 0.001 GO:0044238 BP 1 primary metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.17e-02 2617 8 5 0.625 0.002 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 P49748,P30049,O75964,P56385,P48047 195 1.19e-02 2813 8 6 0.750 0.002 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 P49748,P06576,O75964,O75947,P56385,P48047 195 1.19e-02 1857 8 5 0.625 0.003 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 1.20e-02 1100 8 4 0.500 0.004 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 1.23e-02 1107 8 4 0.500 0.004 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 P24539,O75947,P56385,P48047 195 1.24e-02 5636 8 8 1.000 0.001 HPA:014010_02 hpa 1 esophagus; squamous epithelial cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.26e-02 2 8 1 0.125 0.500 HP:0001958 hp 1 Nonketotic hypoglycemia 1 P49748 195 1.26e-02 10 8 1 0.125 0.100 GO:0036442 MF 1 hydrogen-exporting ATPase activity 1 P06576 195 1.26e-02 10 8 1 0.125 0.100 GO:0046961 MF 1 proton-transporting ATPase activity, rotational mechanism 1 P06576 195 1.26e-02 10 8 1 0.125 0.100 GO:0001659 BP 1 temperature homeostasis 1 P49748 195 1.30e-02 540 8 3 0.375 0.006 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 O75947,P56385,P48047 195 1.32e-02 1129 8 4 0.500 0.004 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P49748,P06576,O75947,P56385 195 1.33e-02 1904 8 5 0.625 0.003 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 1.33e-02 4086 8 7 0.875 0.002 HPA:027020_02 hpa 1 pancreas; islets of Langerhans[Uncertain,Medium] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 1.34e-02 1133 8 4 0.500 0.004 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P06576,O75947,P56385,P48047 195 1.34e-02 5694 8 8 1.000 0.001 HPA:035020_01 hpa 1 skin 1; fibroblasts[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.37e-02 2712 8 5 0.625 0.002 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 P49748,P30049,P24539,P56385,P48047 195 1.38e-02 6266 8 8 1.000 0.001 GO:0044763 BP 1 single-organism cellular process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.39e-02 5717 8 8 1.000 0.001 HPA:041010_01 hpa 1 spleen; cells in red pulp[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.43e-02 3995 8 6 0.750 0.002 TF:M00426_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 P30049,P06576,P24539,O75964,P56385,P48047 195 1.44e-02 6299 8 8 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.51e-02 12 8 1 0.125 0.083 GO:0042287 MF 1 MHC protein binding 1 P06576 195 1.52e-02 2194 8 5 0.625 0.002 GO:0070062 CC 1 extracellular exosome 1 P06576,P24539,O75964,O75947,P48047 195 1.52e-02 5781 8 8 1.000 0.001 HPA:006020_01 hpa 1 cerebellum; cells in granular layer[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.52e-02 5782 8 8 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.52e-02 4600 8 7 0.875 0.002 GO:0016020 CC 1 membrane 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.55e-02 2205 8 5 0.625 0.002 GO:0043230 CC 1 extracellular organelle 1 P06576,P24539,O75964,O75947,P48047 195 1.55e-02 2205 8 5 0.625 0.002 GO:1903561 CC 1 extracellular vesicle 1 P06576,P24539,O75964,O75947,P48047 195 1.55e-02 1179 8 4 0.500 0.003 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 P49748,P06576,O75947,P56385 195 1.58e-02 280 8 2 0.250 0.007 MI:hsa-miR-335* mi 1 MI:hsa-miR-335* 1 P24539,P48047 195 1.60e-02 5819 8 8 1.000 0.001 HPA:033010_02 hpa 1 seminal vesicle; glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.61e-02 1986 8 5 0.625 0.003 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P49748,P06576,O75947,P56385,P48047 195 1.62e-02 1990 8 5 0.625 0.003 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 1.64e-02 13 8 1 0.125 0.077 GO:0090181 BP 1 regulation of cholesterol metabolic process 1 P49748 195 1.65e-02 1998 8 5 0.625 0.003 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P49748,P06576,O75947,P56385,P48047 195 1.65e-02 5844 8 8 1.000 0.001 HPA:012010 hpa 1 endometrium 2; cells in endometrial stroma 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.67e-02 2995 8 6 0.750 0.002 HPA:019020_03 hpa 1 kidney; cells in tubules[Uncertain,High] 1 P06576,P24539,O75964,O75947,P56385,P48047 195 1.75e-02 28 8 1 0.125 0.036 TF:M06101_0 tf 1 Factor: ZNF17; motif: KGGWTYTGCCGC; match class: 0 1 P30049 195 1.75e-02 2024 8 5 0.625 0.002 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P49748,P06576,P24539,O75947,P56385 195 1.76e-02 14 8 1 0.125 0.071 GO:0045922 BP 1 negative regulation of fatty acid metabolic process 1 P49748 195 1.76e-02 14 8 1 0.125 0.071 GO:0052890 MF 1 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1 P49748 195 1.81e-02 6484 8 8 1.000 0.001 GO:0071704 BP 1 organic substance metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 1.82e-02 3045 8 6 0.750 0.002 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 1.83e-02 4185 8 6 0.750 0.001 TF:M03797_1 tf 1 Factor: Msx-2; motif: TWWTTGGDGABN; match class: 1 1 P30049,P06576,P24539,O75964,O75947,P56385 195 1.87e-02 616 8 3 0.375 0.005 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 O75947,P56385,P48047 195 1.88e-02 4308 8 7 0.875 0.002 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 P49748,P06576,P24539,O75964,O75947,P56385,P48047 195 1.89e-02 3 8 1 0.125 0.333 HP:0009045 hp 1 Exercise-induced rhabdomyolysis 1 P49748 195 1.89e-02 15 8 1 0.125 0.067 GO:0003995 MF 1 acyl-CoA dehydrogenase activity 1 P49748 195 1.89e-02 15 8 1 0.125 0.067 GO:0046320 BP 1 regulation of fatty acid oxidation 1 P49748 195 1.94e-02 2072 8 5 0.625 0.002 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P48047 195 1.95e-02 625 8 3 0.375 0.005 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 O75947,P56385,P48047 195 1.95e-02 356 8 2 0.250 0.006 TF:M07066_1 tf 1 Factor: STAT6; motif: TTCYYNGGAAN; match class: 1 1 O75947,P48047 195 2.01e-02 8 8 1 0.125 0.125 REAC:77286 rea 1 mitochondrial fatty acid beta-oxidation of saturated fatty acids 1 P49748 195 2.04e-02 2973 8 5 0.625 0.002 TF:M00427_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 P30049,P24539,O75964,P56385,P48047 195 2.05e-02 1274 8 4 0.500 0.003 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 2.07e-02 2102 8 5 0.625 0.002 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P06576,P24539,O75947,P56385,P48047 195 2.14e-02 17 8 1 0.125 0.059 GO:0033539 BP 1 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1 P49748 195 2.15e-02 7876 8 8 1.000 0.001 TF:M07280_1 tf 1 Factor: LXR,; motif: RGGTCAN; match class: 1 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.17e-02 6046 8 8 1.000 0.001 HPA:008020_01 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.20e-02 6642 8 8 1.000 0.001 GO:0008152 BP 1 metabolic process 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.24e-02 36 8 1 0.125 0.028 TF:M06115_0 tf 1 Factor: ZNF28; motif: NGGGGCGGCAGC; match class: 0 1 P49748 195 2.27e-02 18 8 1 0.125 0.056 GO:0000038 BP 1 very long-chain fatty acid metabolic process 1 P49748 195 2.28e-02 6671 8 8 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.30e-02 37 8 1 0.125 0.027 TF:M05993_0 tf 1 Factor: ZNF711; motif: NTGCGTGCGC; match class: 0 1 P56385 195 2.31e-02 1953 8 4 0.500 0.002 TF:M00428_1 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 1 P30049,O75964,O75947,P56385 195 2.31e-02 2154 8 5 0.625 0.002 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 P06576,P24539,O75947,P56385,P48047 195 2.31e-02 4447 8 7 0.875 0.002 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 2.31e-02 257 8 2 0.250 0.008 GO:0031012 CC 1 extracellular matrix 1 P06576,P48047 195 2.34e-02 392 8 2 0.250 0.005 TF:M06504_0 tf 1 Factor: ZFP62; motif: TNGAAWACCKC; match class: 0 1 P24539,O75947 195 2.36e-02 38 8 1 0.125 0.026 TF:M06080_1 tf 1 Factor: ZNF99; motif: KGGKGTGAGA; match class: 1 1 P49748 195 2.37e-02 6113 8 8 1.000 0.001 HPA:027010_02 hpa 1 pancreas; exocrine glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.39e-02 19 8 1 0.125 0.053 GO:0042304 BP 1 regulation of fatty acid biosynthetic process 1 P49748 195 2.41e-02 5991 8 7 0.875 0.001 TF:M03827_0 tf 1 Factor: HNF-3alpha; motif: RYAAACAN; match class: 0 1 P49748,P30049,P06576,P24539,O75947,P56385,P48047 195 2.41e-02 674 8 3 0.375 0.004 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 O75947,P56385,P48047 195 2.41e-02 3208 8 6 0.750 0.002 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.44e-02 4485 8 7 0.875 0.002 HPA:011010_01 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Low] 1 P49748,P30049,P06576,O75964,O75947,P56385,P48047 195 2.52e-02 20 8 1 0.125 0.050 GO:0000062 MF 1 fatty-acyl-CoA binding 1 P49748 195 2.57e-02 3247 8 6 0.750 0.002 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.59e-02 3143 8 5 0.625 0.002 TF:M01744_0 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 0 1 P30049,P24539,O75947,P56385,P48047 195 2.64e-02 6194 8 8 1.000 0.001 HPA:038010_01 hpa 1 smooth muscle; smooth muscle cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.67e-02 1372 8 4 0.500 0.003 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 P24539,O75947,P56385,P48047 195 2.77e-02 4574 8 7 0.875 0.002 HPA:021010_01 hpa 1 liver; bile duct cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75947,P56385,P48047 195 2.78e-02 2062 8 4 0.500 0.002 TF:M07052_0 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 0 1 P30049,O75964,P56385,P48047 195 2.79e-02 379 8 2 0.250 0.005 MI:hsa-miR-596 mi 1 MI:hsa-miR-596 1 P30049,P06576 195 2.79e-02 45 8 1 0.125 0.022 TF:M06272_0 tf 1 Factor: ZNF569; motif: KGKGGGTGRATM; match class: 0 1 P24539 195 2.81e-02 713 8 3 0.375 0.004 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 O75947,P56385,P48047 195 2.84e-02 382 8 2 0.250 0.005 MI:hsa-miR-92b* mi 1 MI:hsa-miR-92b* 1 P49748,P06576 195 2.84e-02 1396 8 4 0.500 0.003 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 2.85e-02 6256 8 8 1.000 0.001 HPA:026020 hpa 1 ovary; ovarian stroma cells 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 2.86e-02 46 8 1 0.125 0.022 TF:M00024_1 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 1 1 O75947 195 2.88e-02 438 8 2 0.250 0.005 TF:M00427_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 P56385,P48047 195 2.89e-02 23 8 1 0.125 0.043 GO:0043531 MF 1 ADP binding 1 P30049 195 2.92e-02 3326 8 6 0.750 0.002 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.92e-02 3326 8 6 0.750 0.002 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.92e-02 47 8 1 0.125 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 P49748 195 2.92e-02 47 8 1 0.125 0.021 TF:M07207_1 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 1 1 P49748 195 2.93e-02 1408 8 4 0.500 0.003 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 2.95e-02 3334 8 6 0.750 0.002 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 2.99e-02 393 8 2 0.250 0.005 MI:hsa-miR-565 mi 1 MI:hsa-miR-565 1 P49748,P30049 195 3.00e-02 2286 8 5 0.625 0.002 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 P30049,P06576,O75947,P56385,P48047 195 3.00e-02 6295 8 8 1.000 0.001 HPA:011010 hpa 1 endometrium 1; cells in endometrial stroma 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.00e-02 3344 8 6 0.750 0.002 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.00e-02 3344 8 6 0.750 0.002 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.01e-02 2110 8 4 0.500 0.002 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 P24539,O75964,P56385,P48047 195 3.01e-02 1419 8 4 0.500 0.003 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P49748,P06576,O75947,P56385 195 3.03e-02 733 8 3 0.375 0.004 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 O75947,P56385,P48047 195 3.05e-02 3355 8 6 0.750 0.002 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.07e-02 399 8 2 0.250 0.005 MI:hsa-miR-410 mi 1 MI:hsa-miR-410 1 P49748,P56385 195 3.08e-02 3361 8 6 0.750 0.002 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.08e-02 6233 8 7 0.875 0.001 TF:M01660_1 tf 1 Factor: GABPalpha; motif: CTTCCK; match class: 1 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385 195 3.12e-02 3368 8 6 0.750 0.002 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.12e-02 402 8 2 0.250 0.005 MI:mmu-miR-546 mi 1 MI:mmu-miR-546 1 P30049,P48047 195 3.12e-02 402 8 2 0.250 0.005 MI:hsa-miR-127-5p mi 1 MI:hsa-miR-127-5p 1 P30049,P06576 195 3.13e-02 3370 8 6 0.750 0.002 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.13e-02 403 8 2 0.250 0.005 MI:hsa-miR-526b mi 1 MI:hsa-miR-526b 1 P49748,P30049 195 3.14e-02 25 8 1 0.125 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 P49748 195 3.16e-02 51 8 1 0.125 0.020 TF:M06296_0 tf 1 Factor: ZNF568; motif: NTGGGKAAAAGA; match class: 0 1 P24539 195 3.17e-02 3379 8 6 0.750 0.002 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.17e-02 6339 8 8 1.000 0.001 HPA:035040_01 hpa 1 skin 1; melanocytes[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.21e-02 3386 8 6 0.750 0.002 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.21e-02 3386 8 6 0.750 0.002 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.21e-02 3386 8 6 0.750 0.002 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.22e-02 52 8 1 0.125 0.019 TF:M06112_0 tf 1 Factor: ZNF682; motif: NGGGAAGTCKGA; match class: 0 1 P49748 195 3.23e-02 3390 8 6 0.750 0.002 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.29e-02 3403 8 6 0.750 0.002 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.30e-02 3405 8 6 0.750 0.002 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.31e-02 3407 8 6 0.750 0.002 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.31e-02 3407 8 6 0.750 0.002 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.31e-02 472 8 2 0.250 0.004 TF:M04145_1 tf 1 Factor: TEAD4; motif: NRCATTCCWN; match class: 1 1 P49748,O75964 195 3.31e-02 8315 8 8 1.000 0.001 TF:M01035_0 tf 1 Factor: YY1; motif: NYNKCCATNTT; match class: 0 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.32e-02 6993 8 8 1.000 0.001 GO:0005737 CC 1 cytoplasm 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.32e-02 416 8 2 0.250 0.005 MI:hsa-miR-644 mi 1 MI:hsa-miR-644 1 P30049,P06576 195 3.34e-02 2627 8 5 0.625 0.002 GO:0044421 CC 1 extracellular region part 1 P06576,P24539,O75964,O75947,P48047 195 3.34e-02 3412 8 6 0.750 0.002 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.34e-02 3413 8 6 0.750 0.002 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.35e-02 54 8 1 0.125 0.019 TF:M05980_0 tf 1 Factor: zfp64; motif: NATACGGMTC; match class: 0 1 O75964 195 3.35e-02 54 8 1 0.125 0.019 TF:M06351_0 tf 1 Factor: ZNF705A; motif: NCCAAAAAAAYY; match class: 0 1 O75964 195 3.35e-02 3415 8 6 0.750 0.002 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.36e-02 3416 8 6 0.750 0.002 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.36e-02 3416 8 6 0.750 0.002 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.36e-02 3416 8 6 0.750 0.002 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.37e-02 3418 8 6 0.750 0.002 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.38e-02 3420 8 6 0.750 0.002 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.38e-02 3421 8 6 0.750 0.002 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.39e-02 3422 8 6 0.750 0.002 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.39e-02 3422 8 6 0.750 0.002 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.39e-02 3423 8 6 0.750 0.002 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.39e-02 3423 8 6 0.750 0.002 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.40e-02 1219 8 3 0.375 0.002 TF:M00074_1 tf 1 Factor: c-Ets-1(p54); motif: NNACMGGAWRTNN; match class: 1 1 P49748,O75947,P48047 195 3.40e-02 3424 8 6 0.750 0.002 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.40e-02 479 8 2 0.250 0.004 TF:M01714_1 tf 1 Factor: KLF15; motif: GAGNNGGGGNGTDG; match class: 1 1 P49748,O75947 195 3.41e-02 3426 8 6 0.750 0.002 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.41e-02 3426 8 6 0.750 0.002 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.41e-02 1470 8 4 0.500 0.003 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 3.42e-02 480 8 2 0.250 0.004 TF:M01890_0 tf 1 Factor: STAT5A; motif: NNNTTTCTNRGAA; match class: 0 1 P24539,O75964 195 3.42e-02 3428 8 6 0.750 0.002 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.43e-02 3429 8 6 0.750 0.002 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.43e-02 3429 8 6 0.750 0.002 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.43e-02 3429 8 6 0.750 0.002 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.43e-02 3430 8 6 0.750 0.002 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3431 8 6 0.750 0.002 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 424 8 2 0.250 0.005 MI:hsa-miR-555 mi 1 MI:hsa-miR-555 1 P06576,P24539 195 3.44e-02 3432 8 6 0.750 0.002 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.44e-02 3432 8 6 0.750 0.002 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3433 8 6 0.750 0.002 HPA:007030_10 hpa 1 cerebral cortex; neuronal cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3433 8 6 0.750 0.002 HPA:032010_10 hpa 1 salivary gland; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3433 8 6 0.750 0.002 HPA:018020_10 hpa 1 hippocampus; neuronal cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:011020_10 hpa 1 endometrium 1; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:037010_10 hpa 1 small intestine; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:030010_10 hpa 1 prostate; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:007020_10 hpa 1 cerebral cortex; glial cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:021020_10 hpa 1 liver; hepatocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:038010_10 hpa 1 smooth muscle; smooth muscle cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:022010_10 hpa 1 lung; macrophages[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.45e-02 3434 8 6 0.750 0.002 HPA:044010_10 hpa 1 testis; Leydig cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:044020_10 hpa 1 testis; cells in seminiferous ducts[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:019020_10 hpa 1 kidney; cells in tubules[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:017010_10 hpa 1 heart muscle; myocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:022020_10 hpa 1 lung; pneumocytes[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:010010_10 hpa 1 duodenum; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:045010_10 hpa 1 thyroid gland; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:041010_10 hpa 1 spleen; cells in red pulp[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:015010_10 hpa 1 fallopian tube; glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:027010_10 hpa 1 pancreas; exocrine glandular cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 3435 8 6 0.750 0.002 HPA:029020_10 hpa 1 placenta; trophoblastic cells[Supportive,Not detected] 1 P49748,P06576,P24539,O75947,P56385,P48047 195 3.46e-02 2199 8 4 0.500 0.002 TF:M07394_0 tf 1 Factor: slug; motif: CACCTGNNN; match class: 0 1 P30049,O75964,P56385,P48047 195 3.54e-02 4759 8 6 0.750 0.001 TF:M07370_1 tf 1 Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 1 P30049,P06576,P24539,O75947,P56385,P48047 195 3.59e-02 493 8 2 0.250 0.004 TF:M00737_1 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 1 O75947,P56385 195 3.64e-02 4774 8 7 0.875 0.001 HPA:041020_01 hpa 1 spleen; cells in white pulp[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75947,P56385,P48047 195 3.65e-02 59 8 1 0.125 0.017 TF:M06569_0 tf 1 Factor: ZNF775; motif: NYGGGAAAATW; match class: 0 1 O75947 195 3.65e-02 438 8 2 0.250 0.005 MI:gga-miR-757 mi 1 MI:gga-miR-757 1 P30049,O75947 195 3.66e-02 1499 8 4 0.500 0.003 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P24539,O75947,P56385,P48047 195 3.67e-02 2238 8 4 0.500 0.002 TF:M00918_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 P24539,O75964,O75947,P56385 195 3.68e-02 6458 8 8 1.000 0.001 HPA:044010_02 hpa 1 testis; Leydig cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.71e-02 502 8 2 0.250 0.004 TF:M06105_0 tf 1 Factor: ZNF705D; motif: NCCAAAAAAAYY; match class: 0 1 P30049,O75964 195 3.73e-02 6469 8 8 1.000 0.001 HPA:046010_01 hpa 1 tonsil; germinal center cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.75e-02 6474 8 8 1.000 0.001 HPA:027020_01 hpa 1 pancreas; islets of Langerhans[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 3.77e-02 61 8 1 0.125 0.016 TF:M01239_1 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 1 1 P56385 195 3.78e-02 3440 8 5 0.625 0.001 TF:M04306_1 tf 1 Factor: DPRX; motif: NNGGATTANN; match class: 1 1 P49748,P06576,O75964,O75947,P48047 195 3.78e-02 1513 8 4 0.500 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 3.84e-02 511 8 2 0.250 0.004 TF:M04428_0 tf 1 Factor: PITX1; motif: NTTAATCCN; match class: 0 1 P49748,O75947 195 3.86e-02 451 8 2 0.250 0.004 MI:hsa-miR-892b mi 1 MI:hsa-miR-892b 1 P49748,P30049 195 3.95e-02 457 8 2 0.250 0.004 MI:hsa-miR-744 mi 1 MI:hsa-miR-744 1 P49748,P30049 195 3.98e-02 1535 8 4 0.500 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P49748,P24539,P56385,P48047 195 4.00e-02 460 8 2 0.250 0.004 MI:hsa-miR-302b mi 1 MI:hsa-miR-302b 1 P49748,O75964 195 4.01e-02 6528 8 8 1.000 0.001 HPA:008010_01 hpa 1 cervix, uterine; glandular cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.02e-02 2743 8 5 0.625 0.002 GO:0005576 CC 1 extracellular region 1 P06576,P24539,O75964,O75947,P48047 195 4.02e-02 6530 8 8 1.000 0.001 HPA:015010_02 hpa 1 fallopian tube; glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.03e-02 462 8 2 0.250 0.004 MI:mmu-miR-682 mi 1 MI:mmu-miR-682 1 P30049,P06576 195 4.05e-02 463 8 2 0.250 0.004 MI:mmu-miR-327 mi 1 MI:mmu-miR-327 1 P49748,P30049 195 4.08e-02 8535 8 8 1.000 0.001 TF:M01665_0 tf 1 Factor: IRF-8; motif: AGTTTCW; match class: 0 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.16e-02 4876 8 7 0.875 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 P49748,P06576,P24539,O75964,O75947,P56385,P48047 195 4.20e-02 1559 8 4 0.500 0.003 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 P06576,O75947,P56385,P48047 195 4.26e-02 69 8 1 0.125 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 P24539 195 4.26e-02 34 8 1 0.125 0.029 GO:0021762 BP 1 substantia nigra development 1 P24539 195 4.26e-02 34 8 1 0.125 0.029 GO:0019218 BP 1 regulation of steroid metabolic process 1 P49748 195 4.29e-02 478 8 2 0.250 0.004 MI:hsa-miR-486-3p mi 1 MI:hsa-miR-486-3p 1 P49748,P30049 195 4.34e-02 481 8 2 0.250 0.004 MI:hsa-miR-423-5p mi 1 MI:hsa-miR-423-5p 1 P30049,P06576 195 4.35e-02 2795 8 5 0.625 0.002 GO:0031982 CC 1 vesicle 1 P06576,P24539,O75964,O75947,P48047 195 4.36e-02 838 8 3 0.375 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 O75947,P56385,P48047 195 4.38e-02 1578 8 4 0.500 0.003 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 O75964,O75947,P56385,P48047 195 4.39e-02 484 8 2 0.250 0.004 MI:hsa-let-7d mi 1 MI:hsa-let-7d 1 P49748,P06576 195 4.39e-02 840 8 3 0.375 0.004 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 O75947,P56385,P48047 195 4.40e-02 6603 8 8 1.000 0.001 HPA:004030_01 hpa 1 breast; myoepithelial cells[Uncertain,Low] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.42e-02 6607 8 8 1.000 0.001 HPA:002010_02 hpa 1 appendix; glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.43e-02 1583 8 4 0.500 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P06576,O75947,P56385,P48047 195 4.44e-02 72 8 1 0.125 0.014 TF:M06561_0 tf 1 Factor: ZNF502; motif: NGGGWAAGACT; match class: 0 1 P49748 195 4.46e-02 4981 8 6 0.750 0.001 TF:M07248_0 tf 1 Factor: CREB1; motif: NNNNTGACGTNANNN; match class: 0 1 P49748,P30049,P06576,O75964,P56385,P48047 195 4.51e-02 36 8 1 0.125 0.028 GO:0048857 BP 1 neural nucleus development 1 P24539 195 4.51e-02 491 8 2 0.250 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 P06576,O75947 195 4.54e-02 560 8 2 0.250 0.004 TF:M07335_0 tf 1 Factor: Six-1; motif: CTCAGVTTTCT; match class: 0 1 P49748,P56385 195 4.56e-02 494 8 2 0.250 0.004 MI:hsa-miR-452 mi 1 MI:hsa-miR-452 1 P06576,P24539 195 4.59e-02 1600 8 4 0.500 0.003 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P49748,P06576,P24539,P56385 195 4.61e-02 5014 8 6 0.750 0.001 TF:M00074_0 tf 1 Factor: c-Ets-1(p54); motif: NNACMGGAWRTNN; match class: 0 1 P49748,P06576,P24539,O75964,O75947,P48047 195 4.66e-02 6652 8 8 1.000 0.001 HPA:047010_02 hpa 1 urinary bladder; urothelial cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.68e-02 501 8 2 0.250 0.004 MI:mmu-miR-465a-3p mi 1 MI:mmu-miR-465a-3p 1 P49748,P06576 195 4.68e-02 501 8 2 0.250 0.004 MI:hsa-let-7i mi 1 MI:hsa-let-7i 1 P49748,P30049 195 4.69e-02 502 8 2 0.250 0.004 MI:hsa-let-7g mi 1 MI:hsa-let-7g 1 P49748,P30049 195 4.69e-02 502 8 2 0.250 0.004 MI:mmu-miR-703 mi 1 MI:mmu-miR-703 1 P06576,O75964 195 4.72e-02 6661 8 8 1.000 0.001 HPA:040030 hpa 1 soft tissue 2; fibroblasts 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.79e-02 577 8 2 0.250 0.003 TF:M07126_0 tf 1 Factor: Smad2:Smad3:Smad4; motif: NTGTCTGNCACCT; match class: 0 1 O75947,P56385 195 4.80e-02 78 8 1 0.125 0.013 TF:M07339_1 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 1 1 P49748 195 4.81e-02 1621 8 4 0.500 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P06576,O75947,P56385,P48047 195 4.90e-02 514 8 2 0.250 0.004 MI:hsa-miR-320 mi 1 MI:hsa-miR-320 1 P30049,P24539 195 4.91e-02 6694 8 8 1.000 0.001 HPA:039030 hpa 1 soft tissue 1; fibroblasts 1 P49748,P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 4.97e-02 589 8 2 0.250 0.003 TF:M00118_0 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 0 1 P06576,P24539 195 4.97e-02 589 8 2 0.250 0.003 TF:M00118_1 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 1 1 P06576,P24539 195 5.00e-02 3682 8 5 0.625 0.001 TF:M00531_0 tf 1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 0 1 P49748,P30049,O75964,P56385,P48047 195 5.00e-02 15 8 7 0.875 0.467 CORUM:563 cor 1 F1F0-ATP synthase (EC 3.6.3.14), mitochondrial 1 P30049,P06576,P24539,O75964,O75947,P56385,P48047 195 5.00e-02 40 8 1 0.125 0.025 GO:0045833 BP 1 negative regulation of lipid metabolic process 1 P49748 195 5.00e-02 8 8 1 0.125 0.125 HP:0003234 hp 1 Decreased plasma carnitine 1 P49748 195 5.00e-02 40 8 1 0.125 0.025 GO:0050660 MF 1 flavin adenine dinucleotide binding 1 P49748 195 5.00e-02 8 8 1 0.125 0.125 HP:0003738 hp 1 Exercise-induced myalgia 1 P49748 195 5.00e-02 5019 8 7 0.875 0.001 HPA:028010_02 hpa 1 parathyroid gland; glandular cells[Uncertain,Medium] 1 P49748,P30049,P06576,P24539,O75947,P56385,P48047 195 5.00e-02 1 8 1 0.125 1.000 OMIM:201475 omi 1 ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN, DEFICIENCY OF; ACADVLD;;VLCAD DEFICIENCY 1 P49748 195 5.00e-02 8 8 1 0.125 0.125 HP:0010967 hp 1 Abnormality of carnitine metabolism 1 P49748 195 5.00e-02 20 8 1 0.125 0.050 REAC:77289 rea 1 Mitochondrial Fatty Acid Beta-Oxidation 1 P49748 195 5.00e-02 8 8 1 0.125 0.125 HP:0010966 hp 1 Abnormality of fatty-acid anion metabolism 1 P49748 196 5.12e-08 34 3 3 1.000 0.088 GO:0005669 CC 1 transcription factor TFIID complex 1 Q6P1X5,P20226,Q15542 196 5.75e-08 9 3 3 1.000 0.333 CORUM:155 cor 1 TFIID complex 1 Q6P1X5,P20226,Q15542 196 5.75e-08 9 3 3 1.000 0.333 CORUM:3009 cor 1 TFIID complex 1 Q6P1X5,P20226,Q15542 196 1.50e-07 12 3 3 1.000 0.250 CORUM:469 cor 1 TFIID-beta complex 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:167162 rea 1 RNA Polymerase II HIV Promoter Escape 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:73779 rea 1 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:75953 rea 1 RNA Polymerase II Transcription Initiation 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:73776 rea 1 RNA Polymerase II Promoter Escape 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:76042 rea 1 RNA Polymerase II Transcription Initiation And Promoter Clearance 1 Q6P1X5,P20226,Q15542 196 2.92e-07 46 3 3 1.000 0.065 REAC:167161 rea 1 HIV Transcription Initiation 1 Q6P1X5,P20226,Q15542 196 3.11e-07 15 3 3 1.000 0.200 CORUM:492 cor 1 DA complex 1 Q6P1X5,P20226,Q15542 196 3.83e-07 16 3 3 1.000 0.188 CORUM:493 cor 1 DAB complex 1 Q6P1X5,P20226,Q15542 196 9.72e-07 89 3 3 1.000 0.034 GO:0090575 CC 1 RNA polymerase II transcription factor complex 1 Q6P1X5,P20226,Q15542 196 9.72e-07 89 3 3 1.000 0.034 GO:0006368 BP 1 transcription elongation from RNA polymerase II promoter 1 Q6P1X5,P20226,Q15542 196 1.01e-06 69 3 3 1.000 0.043 REAC:167172 rea 1 Transcription of the HIV genome 1 Q6P1X5,P20226,Q15542 196 1.07e-06 92 3 3 1.000 0.033 GO:0016591 CC 1 DNA-directed RNA polymerase II, holoenzyme 1 Q6P1X5,P20226,Q15542 196 1.43e-06 101 3 3 1.000 0.030 GO:0044798 CC 1 nuclear transcription factor complex 1 Q6P1X5,P20226,Q15542 196 1.52e-06 79 3 3 1.000 0.038 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 Q6P1X5,P20226,Q15542 196 1.97e-06 86 3 3 1.000 0.035 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q6P1X5,P20226,Q15542 196 2.06e-06 114 3 3 1.000 0.026 GO:0000428 CC 1 DNA-directed RNA polymerase complex 1 Q6P1X5,P20226,Q15542 196 2.06e-06 114 3 3 1.000 0.026 GO:0055029 CC 1 nuclear DNA-directed RNA polymerase complex 1 Q6P1X5,P20226,Q15542 196 2.11e-06 115 3 3 1.000 0.026 GO:0006354 BP 1 DNA-templated transcription, elongation 1 Q6P1X5,P20226,Q15542 196 2.17e-06 116 3 3 1.000 0.026 GO:0030880 CC 1 RNA polymerase complex 1 Q6P1X5,P20226,Q15542 196 3.51e-06 136 3 3 1.000 0.022 GO:0006367 BP 1 transcription initiation from RNA polymerase II promoter 1 Q6P1X5,P20226,Q15542 196 3.75e-06 139 3 3 1.000 0.022 GO:1901796 BP 1 regulation of signal transduction by p53 class mediator 1 Q6P1X5,P20226,Q15542 196 6.64e-06 168 3 3 1.000 0.018 GO:0005667 CC 1 transcription factor complex 1 Q6P1X5,P20226,Q15542 196 6.72e-06 129 3 3 1.000 0.023 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 Q6P1X5,P20226,Q15542 196 7.01e-06 171 3 3 1.000 0.018 GO:0006352 BP 1 DNA-templated transcription, initiation 1 Q6P1X5,P20226,Q15542 196 8.61e-06 140 3 3 1.000 0.021 REAC:73857 rea 1 RNA Polymerase II Transcription 1 Q6P1X5,P20226,Q15542 196 8.61e-06 140 3 3 1.000 0.021 REAC:162587 rea 1 HIV Life Cycle 1 Q6P1X5,P20226,Q15542 196 8.97e-06 14 3 2 0.667 0.143 GO:0033276 CC 1 transcription factor TFTC complex 1 Q6P1X5,Q15542 196 1.06e-05 150 3 3 1.000 0.020 REAC:5633007 rea 1 Regulation of TP53 Activity 1 Q6P1X5,P20226,Q15542 196 1.19e-05 43 3 3 1.000 0.070 KEGG:03022 keg 1 Basal transcription factors 1 Q6P1X5,P20226,Q15542 196 1.23e-05 206 3 3 1.000 0.015 GO:0072331 BP 1 signal transduction by p53 class mediator 1 Q6P1X5,P20226,Q15542 196 1.42e-05 216 3 3 1.000 0.014 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q6P1X5,P20226,Q15542 196 1.57e-05 5 3 2 0.667 0.400 CORUM:1321 cor 1 Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP) 1 P20226,Q15542 196 1.57e-05 5 3 2 0.667 0.400 CORUM:1318 cor 1 Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP) 1 P20226,Q15542 196 3.32e-05 219 3 3 1.000 0.014 REAC:162906 rea 1 HIV Infection 1 Q6P1X5,P20226,Q15542 196 4.29e-05 30 3 2 0.667 0.067 GO:0070461 CC 1 SAGA-type complex 1 Q6P1X5,Q15542 196 7.06e-05 10 3 2 0.667 0.200 CORUM:508 cor 1 TFIID complex 1 P20226,Q15542 196 8.62e-05 11 3 2 0.667 0.182 CORUM:463 cor 1 TFIID-beta complex 1 P20226,Q15542 196 8.62e-05 11 3 2 0.667 0.182 CORUM:484 cor 1 TFIID complex 1 P20226,Q15542 196 1.03e-04 12 3 2 0.667 0.167 CORUM:485 cor 1 TFIID complex, B-cell specific 1 P20226,Q15542 196 1.03e-04 12 3 2 0.667 0.167 CORUM:509 cor 1 TFIID complex 1 P20226,Q15542 196 1.03e-04 12 3 2 0.667 0.167 CORUM:514 cor 1 TFIID-beta complex 1 P20226,Q15542 196 1.14e-04 432 3 3 1.000 0.007 GO:0000975 MF 1 regulatory region DNA binding 1 Q6P1X5,P20226,Q15542 196 1.14e-04 432 3 3 1.000 0.007 GO:0001067 MF 1 regulatory region nucleic acid binding 1 Q6P1X5,P20226,Q15542 196 1.14e-04 432 3 3 1.000 0.007 GO:0044212 MF 1 transcription regulatory region DNA binding 1 Q6P1X5,P20226,Q15542 196 1.15e-04 331 3 3 1.000 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q6P1X5,P20226,Q15542 196 1.32e-04 346 3 3 1.000 0.009 REAC:5663205 rea 1 Infectious disease 1 Q6P1X5,P20226,Q15542 196 1.88e-04 16 3 2 0.667 0.125 CORUM:462 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 1.88e-04 16 3 2 0.667 0.125 CORUM:459 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 1.88e-04 16 3 2 0.667 0.125 CORUM:445 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 1.88e-04 16 3 2 0.667 0.125 CORUM:456 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 1.88e-04 16 3 2 0.667 0.125 CORUM:455 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 2.01e-04 521 3 3 1.000 0.006 GO:0044451 CC 1 nucleoplasm part 1 Q6P1X5,P20226,Q15542 196 2.13e-04 17 3 2 0.667 0.118 CORUM:513 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 2.13e-04 17 3 2 0.667 0.118 CORUM:470 cor 1 TFTC complex (TATA-binding protein-free TAF-II-containing complex) 1 Q6P1X5,Q15542 196 2.37e-04 70 3 2 0.667 0.029 GO:0009301 BP 1 snRNA transcription 1 P20226,Q15542 196 2.37e-04 70 3 2 0.667 0.029 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 P20226,Q15542 196 3.18e-04 81 3 2 0.667 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q6P1X5,Q15542 196 3.33e-04 70 3 2 0.667 0.029 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 P20226,Q15542 196 3.42e-04 84 3 2 0.667 0.024 GO:0016073 BP 1 snRNA metabolic process 1 P20226,Q15542 196 3.45e-04 624 3 3 1.000 0.005 GO:1990234 CC 1 transferase complex 1 Q6P1X5,P20226,Q15542 196 4.02e-04 91 3 2 0.667 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q6P1X5,Q15542 196 4.02e-04 91 3 2 0.667 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q6P1X5,Q15542 196 4.11e-04 92 3 2 0.667 0.022 GO:0098781 BP 1 ncRNA transcription 1 P20226,Q15542 196 4.29e-04 671 3 3 1.000 0.004 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 Q6P1X5,P20226,Q15542 196 4.29e-04 671 3 3 1.000 0.004 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 Q6P1X5,P20226,Q15542 196 5.69e-04 1 3 1 0.333 1.000 GO:0001034 MF 1 RNA polymerase III transcription factor activity, sequence-specific DNA binding 1 P20226 196 7.90e-04 628 3 3 1.000 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 Q6P1X5,P20226,Q15542 196 1.11e-03 922 3 3 1.000 0.003 GO:0003677 MF 1 DNA binding 1 Q6P1X5,P20226,Q15542 196 1.19e-03 720 3 3 1.000 0.004 REAC:1643685 rea 1 Disease 1 Q6P1X5,P20226,Q15542 196 1.54e-03 1027 3 3 1.000 0.003 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q6P1X5,P20226,Q15542 196 1.57e-03 1033 3 3 1.000 0.003 GO:1902494 CC 1 catalytic complex 1 Q6P1X5,P20226,Q15542 196 1.71e-03 3 3 1 0.333 0.333 GO:0001132 MF 1 RNA polymerase II transcription factor activity, TBP-class protein binding 1 Q6P1X5 196 1.71e-03 3 3 1 0.333 0.333 GO:0001129 MF 1 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly 1 Q6P1X5 196 1.71e-03 3 3 1 0.333 0.333 GO:0005672 CC 1 transcription factor TFIIA complex 1 P20226 196 1.81e-03 1 3 1 0.333 1.000 CORUM:721 cor 1 PU.1-TBP complex 1 P20226 196 1.96e-03 201 3 2 0.667 0.010 GO:0000790 CC 1 nuclear chromatin 1 P20226,Q15542 196 2.28e-03 4 3 1 0.333 0.250 GO:0001083 MF 1 transcription factor activity, RNA polymerase II basal transcription factor binding 1 Q6P1X5 196 2.32e-03 1177 3 3 1.000 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q6P1X5,P20226,Q15542 196 2.96e-03 1 3 1 0.333 1.000 OMIM:607136 omi 1 SPINOCEREBELLAR ATAXIA 17; SCA17;;HUNTINGTON DISEASE-LIKE 4; HDL4 1 P20226 196 2.96e-03 1 3 1 0.333 1.000 OMIM:615599 omi 1 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 40; MRT40 1 Q6P1X5 196 3.13e-03 1863 3 3 1.000 0.002 TF:M00411_0 tf 1 Factor: HNF4alpha1; motif: NRGGNCAAAGGTCAN; match class: 0 1 Q6P1X5,P20226,Q15542 196 4.18e-03 294 3 2 0.667 0.007 GO:0000785 CC 1 chromatin 1 P20226,Q15542 196 4.83e-03 2153 3 3 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 Q6P1X5,P20226,Q15542 196 4.83e-03 2153 3 3 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 Q6P1X5,P20226,Q15542 196 5.12e-03 9 3 1 0.333 0.111 GO:0001075 MF 1 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly 1 Q6P1X5 196 5.13e-03 1533 3 3 1.000 0.002 GO:0035556 BP 1 intracellular signal transduction 1 Q6P1X5,P20226,Q15542 196 5.42e-03 3 3 1 0.333 0.333 CORUM:5736 cor 1 Pre-initiation complex (PIC) 1 P20226 196 5.54e-03 1573 3 3 1.000 0.002 GO:0009966 BP 1 regulation of signal transduction 1 Q6P1X5,P20226,Q15542 196 6.14e-03 357 3 2 0.667 0.006 GO:0044454 CC 1 nuclear chromosome part 1 P20226,Q15542 196 6.88e-03 1691 3 3 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 Q6P1X5,P20226,Q15542 196 7.06e-03 383 3 2 0.667 0.005 GO:0000228 CC 1 nuclear chromosome 1 P20226,Q15542 196 7.22e-03 4 3 1 0.333 0.250 CORUM:5727 cor 1 TBP-TAF complex 1 P20226 196 7.29e-03 31 3 1 0.333 0.032 TF:M05758_0 tf 1 Factor: ZNF699; motif: NGKATYAAAATA; match class: 0 1 Q6P1X5 196 7.35e-03 1728 3 3 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 Q6P1X5,P20226,Q15542 196 7.96e-03 14 3 1 0.333 0.071 GO:0005719 CC 1 nuclear euchromatin 1 P20226 196 9.02e-03 5 3 1 0.333 0.200 CORUM:3010 cor 1 TFIID subcomplex 1 Q15542 196 9.11e-03 2659 3 3 1.000 0.001 TF:M04440_0 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 0 1 Q6P1X5,P20226,Q15542 196 9.24e-03 1865 3 3 1.000 0.002 GO:0006351 BP 1 transcription, DNA-templated 1 Q6P1X5,P20226,Q15542 196 9.34e-03 1872 3 3 1.000 0.002 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q6P1X5,P20226,Q15542 196 9.66e-03 17 3 1 0.333 0.059 GO:0000791 CC 1 euchromatin 1 P20226 196 1.02e-02 18 3 1 0.333 0.056 GO:0000983 MF 1 transcription factor activity, RNA polymerase II core promoter sequence-specific 1 Q6P1X5 196 1.05e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 Q6P1X5,P20226,Q15542 196 1.10e-02 22 3 1 0.333 0.045 REAC:427359 rea 1 SIRT1 negatively regulates rRNA Expression 1 P20226 196 1.11e-02 1980 3 3 1.000 0.002 GO:0032774 BP 1 RNA biosynthetic process 1 Q6P1X5,P20226,Q15542 196 1.16e-02 492 3 2 0.667 0.004 GO:0034660 BP 1 ncRNA metabolic process 1 P20226,Q15542 196 1.20e-02 51 3 1 0.333 0.020 TF:M06972_0 tf 1 Factor: DUX3; motif: TTAATTTAATTAA; match class: 0 1 Q6P1X5 196 1.20e-02 51 3 1 0.333 0.020 TF:M06988_0 tf 1 Factor: DUX4; motif: TTAATTTAATTAA; match class: 0 1 Q6P1X5 196 1.30e-02 26 3 1 0.333 0.038 REAC:76066 rea 1 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1 P20226 196 1.31e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 Q6P1X5,P20226,Q15542 196 1.32e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 Q6P1X5,P20226,Q15542 196 1.35e-02 27 3 1 0.333 0.037 REAC:76061 rea 1 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1 P20226 196 1.35e-02 27 3 1 0.333 0.037 REAC:76071 rea 1 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1 P20226 196 1.39e-02 2136 3 3 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 Q6P1X5,P20226,Q15542 196 1.50e-02 30 3 1 0.333 0.033 REAC:73772 rea 1 RNA Polymerase I Promoter Escape 1 P20226 196 1.52e-02 565 3 2 0.667 0.004 GO:0044427 CC 1 chromosomal part 1 P20226,Q15542 196 1.55e-02 31 3 1 0.333 0.032 REAC:73863 rea 1 RNA Polymerase I Transcription Termination 1 P20226 196 1.59e-02 68 3 1 0.333 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 P20226 196 1.62e-02 9 3 1 0.333 0.111 CORUM:1114 cor 1 5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex 1 P20226 196 1.65e-02 29 3 1 0.333 0.034 GO:0006362 BP 1 transcription elongation from RNA polymerase I promoter 1 P20226 196 1.66e-02 2267 3 3 1.000 0.001 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q6P1X5,P20226,Q15542 196 1.70e-02 34 3 1 0.333 0.029 REAC:76046 rea 1 RNA Polymerase III Transcription Initiation 1 P20226 196 1.74e-02 2305 3 3 1.000 0.001 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q6P1X5,P20226,Q15542 196 1.76e-02 2310 3 3 1.000 0.001 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q6P1X5,P20226,Q15542 196 1.76e-02 31 3 1 0.333 0.032 GO:0006363 BP 1 termination of RNA polymerase I transcription 1 P20226 196 1.76e-02 609 3 2 0.667 0.003 GO:0005694 CC 1 chromosome 1 P20226,Q15542 196 1.80e-02 10 3 1 0.333 0.100 CORUM:1749 cor 1 SMN-PolII-RHA complex 1 P20226 196 1.85e-02 37 3 1 0.333 0.027 REAC:749476 rea 1 RNA Polymerase III Abortive And Retractive Initiation 1 P20226 196 1.85e-02 37 3 1 0.333 0.027 REAC:74158 rea 1 RNA Polymerase III Transcription 1 P20226 196 1.87e-02 33 3 1 0.333 0.030 GO:0006361 BP 1 transcription initiation from RNA polymerase I promoter 1 P20226 196 1.91e-02 2374 3 3 1.000 0.001 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q6P1X5,P20226,Q15542 196 2.19e-02 1122 3 2 0.667 0.002 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 Q6P1X5,P20226 196 2.20e-02 44 3 1 0.333 0.023 REAC:73777 rea 1 RNA Polymerase I Chain Elongation 1 P20226 196 2.25e-02 45 3 1 0.333 0.022 REAC:5250924 rea 1 B-WICH complex positively regulates rRNA expression 1 P20226 196 2.27e-02 40 3 1 0.333 0.025 GO:0006383 BP 1 transcription from RNA polymerase III promoter 1 P20226 196 2.30e-02 2529 3 3 1.000 0.001 GO:0005654 CC 1 nucleoplasm 1 Q6P1X5,P20226,Q15542 196 2.31e-02 3626 3 3 1.000 0.001 TF:M00373_0 tf 1 Factor: Pax-4; motif: NGNVGTCANGCGTGNNSNNYN; match class: 0 1 Q6P1X5,P20226,Q15542 196 2.34e-02 47 3 1 0.333 0.021 REAC:73762 rea 1 RNA Polymerase I Transcription Initiation 1 P20226 196 2.38e-02 42 3 1 0.333 0.024 GO:0070491 MF 1 repressing transcription factor binding 1 P20226 196 2.39e-02 102 3 1 0.333 0.010 TF:M07089_1 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 1 1 P20226 196 2.50e-02 1200 3 2 0.667 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q6P1X5,P20226 196 2.54e-02 2612 3 3 1.000 0.001 GO:1901363 MF 1 heterocyclic compound binding 1 Q6P1X5,P20226,Q15542 196 2.58e-02 2627 3 3 1.000 0.001 GO:0016070 BP 1 RNA metabolic process 1 Q6P1X5,P20226,Q15542 196 2.61e-02 46 3 1 0.333 0.022 GO:0045815 BP 1 positive regulation of gene expression, epigenetic 1 P20226 196 2.68e-02 2660 3 3 1.000 0.001 GO:0097159 MF 1 organic cyclic compound binding 1 Q6P1X5,P20226,Q15542 196 2.70e-02 3821 3 3 1.000 0.001 TF:M04415_0 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 0 1 Q6P1X5,P20226,Q15542 196 2.83e-02 2707 3 3 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q6P1X5,P20226,Q15542 196 2.83e-02 50 3 1 0.333 0.020 GO:0004402 MF 1 histone acetyltransferase activity 1 Q15542 196 2.89e-02 51 3 1 0.333 0.020 GO:0006360 BP 1 transcription from RNA polymerase I promoter 1 P20226 196 2.89e-02 51 3 1 0.333 0.020 GO:0061733 MF 1 peptide-lysine-N-acetyltransferase activity 1 Q15542 196 2.99e-02 60 3 1 0.333 0.017 REAC:427413 rea 1 NoRC negatively regulates rRNA expression 1 P20226 196 2.99e-02 60 3 1 0.333 0.017 REAC:5250913 rea 1 Positive epigenetic regulation of rRNA expression 1 P20226 196 3.01e-02 129 3 1 0.333 0.008 TF:M04107_0 tf 1 Factor: RUNX2; motif: WRACCGCANWAACCGCAN; match class: 0 1 Q6P1X5 196 3.03e-02 2770 3 3 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q6P1X5,P20226,Q15542 196 3.14e-02 63 3 1 0.333 0.016 REAC:73854 rea 1 RNA Polymerase I Promoter Clearance 1 P20226 196 3.14e-02 63 3 1 0.333 0.016 REAC:5250941 rea 1 Negative epigenetic regulation of rRNA expression 1 P20226 196 3.15e-02 135 3 1 0.333 0.007 TF:M06508_0 tf 1 Factor: ZNF114; motif: GGCCGGSTAA; match class: 0 1 Q15542 196 3.17e-02 1359 3 2 0.667 0.001 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q6P1X5,Q15542 196 3.22e-02 138 3 1 0.333 0.007 TF:M02091_0 tf 1 Factor: E4F1; motif: RTGACGTAAC; match class: 0 1 Q15542 196 3.23e-02 18 3 1 0.333 0.056 CORUM:3064 cor 1 RNA polymerase II complex, chromatin structure modifying 1 P20226 196 3.23e-02 65 3 1 0.333 0.015 REAC:73864 rea 1 RNA Polymerase I Transcription 1 P20226 196 3.28e-02 58 3 1 0.333 0.017 GO:0034212 MF 1 peptide N-acetyltransferase activity 1 Q15542 196 3.36e-02 4107 3 3 1.000 0.001 TF:M00729_0 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 0 1 Q6P1X5,P20226,Q15542 196 3.36e-02 2869 3 3 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q6P1X5,P20226,Q15542 196 3.47e-02 384 3 2 0.667 0.005 MI:hsa-miR-186 mi 1 MI:hsa-miR-186 1 Q6P1X5,P20226 196 3.57e-02 4190 3 3 1.000 0.001 TF:M04436_0 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 0 1 Q6P1X5,P20226,Q15542 196 3.57e-02 1444 3 2 0.667 0.001 TF:M07089_0 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 0 1 P20226,Q15542 196 3.58e-02 1446 3 2 0.667 0.001 TF:M07327_1 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 1 1 Q6P1X5,P20226 196 3.59e-02 2931 3 3 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 Q6P1X5,P20226,Q15542 196 3.60e-02 1451 3 2 0.667 0.001 TF:M07417_0 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 0 1 P20226,Q15542 196 3.68e-02 4233 3 3 1.000 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 Q6P1X5,P20226,Q15542 196 3.73e-02 136 3 1 0.333 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q15542 196 3.77e-02 162 3 1 0.333 0.006 TF:M04018_0 tf 1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 0 1 P20226 196 3.79e-02 163 3 1 0.333 0.006 TF:M05697_0 tf 1 Factor: ZNF235; motif: NCCGCWAAAYGC; match class: 0 1 P20226 196 3.86e-02 4302 3 3 1.000 0.001 TF:M04402_1 tf 1 Factor: MIXL1; motif: NNYAATTANN; match class: 1 1 Q6P1X5,P20226,Q15542 196 3.86e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 Q6P1X5,P20226,Q15542 196 3.90e-02 3013 3 3 1.000 0.001 GO:0090304 BP 1 nucleic acid metabolic process 1 Q6P1X5,P20226,Q15542 196 3.91e-02 168 3 1 0.333 0.006 TF:M00804_1 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 1 1 Q15542 196 3.97e-02 922 3 2 0.667 0.002 GO:0010628 BP 1 positive regulation of gene expression 1 Q6P1X5,P20226 196 3.99e-02 1530 3 2 0.667 0.001 TF:M04357_0 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 0 1 P20226,Q15542 196 3.99e-02 1530 3 2 0.667 0.001 TF:M04363_0 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 0 1 P20226,Q15542 196 4.02e-02 71 3 1 0.333 0.014 GO:0008080 MF 1 N-acetyltransferase activity 1 Q15542 196 4.03e-02 147 3 1 0.333 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q15542 196 4.06e-02 148 3 1 0.333 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q15542 196 4.07e-02 3058 3 3 1.000 0.001 GO:0010467 BP 1 gene expression 1 Q6P1X5,P20226,Q15542 196 4.14e-02 178 3 1 0.333 0.006 TF:M06060_0 tf 1 Factor: ZNF729; motif: GTTGAGAAGA; match class: 0 1 Q6P1X5 196 4.16e-02 179 3 1 0.333 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 Q6P1X5 196 4.16e-02 1565 3 2 0.667 0.001 TF:M00422_1 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 1 1 Q6P1X5,P20226 196 4.21e-02 181 3 1 0.333 0.006 TF:M00420_0 tf 1 Factor: MEIS1A:HOXA9; motif: TGACAGKTTTAYGA; match class: 0 1 P20226 196 4.21e-02 181 3 1 0.333 0.006 TF:M03966_0 tf 1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 0 1 P20226 196 4.23e-02 182 3 1 0.333 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 Q15542 196 4.27e-02 184 3 1 0.333 0.005 TF:M05623_0 tf 1 Factor: ZNF73; motif: NGNTGGWACAGA; match class: 0 1 P20226 196 4.29e-02 24 3 1 0.333 0.042 CORUM:103 cor 1 RNA polymerase II holoenzyme complex 1 P20226 196 4.39e-02 4492 3 3 1.000 0.001 TF:M00339_0 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 0 1 Q6P1X5,P20226,Q15542 196 4.52e-02 80 3 1 0.333 0.013 GO:0016410 MF 1 N-acyltransferase activity 1 Q15542 196 4.53e-02 3168 3 3 1.000 0.001 GO:0044428 CC 1 nuclear part 1 Q6P1X5,P20226,Q15542 196 4.63e-02 82 3 1 0.333 0.012 GO:0016407 MF 1 acetyltransferase activity 1 Q15542 196 4.64e-02 4575 3 3 1.000 0.001 TF:M04443_1 tf 1 Factor: UNCX; motif: NYAATTAN; match class: 1 1 Q6P1X5,P20226,Q15542 196 4.65e-02 26 3 1 0.333 0.038 CORUM:2825 cor 1 BRCA1-RNA polymerase II complex 1 P20226 196 4.69e-02 83 3 1 0.333 0.012 GO:0001076 MF 1 transcription factor activity, RNA polymerase II transcription factor binding 1 Q6P1X5 196 4.82e-02 1690 3 2 0.667 0.001 TF:M03802_1 tf 1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 1 Q6P1X5,Q15542 196 4.85e-02 98 3 1 0.333 0.010 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 P20226 196 4.95e-02 3262 3 3 1.000 0.001 GO:0007154 BP 1 cell communication 1 Q6P1X5,P20226,Q15542 196 4.97e-02 3268 3 3 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 Q6P1X5,P20226,Q15542 196 4.98e-02 215 3 1 0.333 0.005 TF:M07082_0 tf 1 Factor: DUX4; motif: TAAYYYAATCA; match class: 0 1 Q6P1X5 196 5.00e-02 1723 3 2 0.667 0.001 TF:M04234_0 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 0 1 Q6P1X5,P20226 196 5.00e-02 145 3 2 0.667 0.014 KEGG:05168 keg 1 Herpes simplex infection 1 P20226,Q15542 196 5.00e-02 1 3 1 0.333 1.000 HP:0007668 hp 1 Impaired pursuit initiation and maintenance 1 P20226 196 5.00e-02 101 3 1 0.333 0.010 REAC:212165 rea 1 Epigenetic regulation of gene expression 1 P20226 196 5.00e-02 3274 3 3 1.000 0.001 GO:0023052 BP 1 signaling 1 Q6P1X5,P20226,Q15542 196 5.00e-02 28 3 1 0.333 0.036 CORUM:1257 cor 1 ALL-1 supercomplex 1 P20226 196 5.00e-02 462 3 2 0.667 0.004 MI:hsa-miR-107 mi 1 MI:hsa-miR-107 1 P20226,Q15542 196 5.00e-02 17 3 1 0.333 0.059 OMIM:168600 omi 1 Parkinson Disease 1 P20226 197 1.13e-10 5 3 3 1.000 0.600 GO:0008622 CC 1 epsilon DNA polymerase complex 1 Q9NR33,Q9NRF9,Q07864 197 4.11e-09 14 3 3 1.000 0.214 GO:0000109 CC 1 nucleotide-excision repair complex 1 Q9NR33,Q9NRF9,Q07864 197 4.11e-09 14 3 3 1.000 0.214 GO:0042575 CC 1 DNA polymerase complex 1 Q9NR33,Q9NRF9,Q07864 197 1.09e-08 19 3 3 1.000 0.158 GO:0003887 MF 1 DNA-directed DNA polymerase activity 1 Q9NR33,Q9NRF9,Q07864 197 2.93e-08 26 3 3 1.000 0.115 GO:0043601 CC 1 nuclear replisome 1 Q9NR33,Q9NRF9,Q07864 197 2.93e-08 26 3 3 1.000 0.115 GO:0034061 MF 1 DNA polymerase activity 1 Q9NR33,Q9NRF9,Q07864 197 3.30e-08 27 3 3 1.000 0.111 GO:0030894 CC 1 replisome 1 Q9NR33,Q9NRF9,Q07864 197 8.77e-08 37 3 3 1.000 0.081 GO:1990391 CC 1 DNA repair complex 1 Q9NR33,Q9NRF9,Q07864 197 1.03e-07 8 3 3 1.000 0.375 REAC:174430 rea 1 Telomere C-strand synthesis initiation 1 Q9NR33,Q9NRF9,Q07864 197 1.03e-07 8 3 3 1.000 0.375 REAC:68952 rea 1 DNA replication initiation 1 Q9NR33,Q9NRF9,Q07864 197 1.11e-07 40 3 3 1.000 0.075 GO:0043596 CC 1 nuclear replication fork 1 Q9NR33,Q9NRF9,Q07864 197 3.13e-07 56 3 3 1.000 0.054 GO:0005657 CC 1 replication fork 1 Q9NR33,Q9NRF9,Q07864 197 6.66e-07 15 3 3 1.000 0.200 CORUM:1108 cor 1 DNA synthesome complex (15 subunits) 1 Q9NR33,Q9NRF9,Q07864 197 7.02e-07 73 3 3 1.000 0.041 GO:0032993 CC 1 protein-DNA complex 1 Q9NR33,Q9NRF9,Q07864 197 1.17e-06 31 3 3 1.000 0.097 KEGG:03410 keg 1 Base excision repair 1 Q9NR33,Q9NRF9,Q07864 197 1.19e-06 18 3 3 1.000 0.167 CORUM:1099 cor 1 DNA synthesome complex (17 subunits) 1 Q9NR33,Q9NRF9,Q07864 197 1.19e-06 18 3 3 1.000 0.167 CORUM:1111 cor 1 DNA synthesome complex (17 subunits) 1 Q9NR33,Q9NRF9,Q07864 197 1.87e-06 36 3 3 1.000 0.083 KEGG:03030 keg 1 DNA replication 1 Q9NR33,Q9NRF9,Q07864 197 2.12e-06 105 3 3 1.000 0.029 GO:0016779 MF 1 nucleotidyltransferase activity 1 Q9NR33,Q9NRF9,Q07864 197 2.45e-06 21 3 3 1.000 0.143 REAC:5651801 rea 1 PCNA-Dependent Long Patch Base Excision Repair 1 Q9NR33,Q9NRF9,Q07864 197 3.71e-06 45 3 3 1.000 0.067 KEGG:03420 keg 1 Nucleotide excision repair 1 Q9NR33,Q9NRF9,Q07864 197 3.73e-06 24 3 3 1.000 0.125 REAC:174417 rea 1 Telomere C-strand (Lagging Strand) Synthesis 1 Q9NR33,Q9NRF9,Q07864 197 3.73e-06 24 3 3 1.000 0.125 REAC:5696397 rea 1 Gap-filling DNA repair synthesis and ligation in GG-NER 1 Q9NR33,Q9NRF9,Q07864 197 3.73e-06 24 3 3 1.000 0.125 REAC:110373 rea 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 Q9NR33,Q9NRF9,Q07864 197 6.04e-06 28 3 3 1.000 0.107 REAC:110314 rea 1 Recognition of DNA damage by PCNA-containing replication complex 1 Q9NR33,Q9NRF9,Q07864 197 6.73e-06 29 3 3 1.000 0.103 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 Q9NR33,Q9NRF9,Q07864 197 7.48e-06 30 3 3 1.000 0.100 REAC:180786 rea 1 Extension of Telomeres 1 Q9NR33,Q9NRF9,Q07864 197 8.28e-06 31 3 3 1.000 0.097 REAC:68962 rea 1 Activation of the pre-replicative complex 1 Q9NR33,Q9NRF9,Q07864 197 1.18e-05 14 3 2 0.667 0.143 GO:0005671 CC 1 Ada2/Gcn5/Ada3 transcription activator complex 1 Q9NR33,Q9NRF9 197 1.21e-05 35 3 3 1.000 0.086 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 Q9NR33,Q9NRF9,Q07864 197 1.21e-05 35 3 3 1.000 0.086 REAC:73884 rea 1 Base Excision Repair 1 Q9NR33,Q9NRF9,Q07864 197 1.32e-05 36 3 3 1.000 0.083 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 Q9NR33,Q9NRF9,Q07864 197 1.82e-05 40 3 3 1.000 0.075 REAC:5696400 rea 1 Dual Incision in GG-NER 1 Q9NR33,Q9NRF9,Q07864 197 1.87e-05 216 3 3 1.000 0.014 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q9NR33,Q9NRF9,Q07864 197 2.44e-05 44 3 3 1.000 0.068 REAC:73893 rea 1 DNA Damage Bypass 1 Q9NR33,Q9NRF9,Q07864 197 3.62e-05 95 3 3 1.000 0.032 KEGG:00240 keg 1 Pyrimidine metabolism 1 Q9NR33,Q9NRF9,Q07864 197 3.84e-05 51 3 3 1.000 0.059 REAC:157579 rea 1 Telomere Maintenance 1 Q9NR33,Q9NRF9,Q07864 197 6.63e-05 61 3 3 1.000 0.049 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q9NR33,Q9NRF9,Q07864 197 7.32e-05 63 3 3 1.000 0.048 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 Q9NR33,Q9NRF9,Q07864 197 7.68e-05 64 3 3 1.000 0.047 REAC:6782135 rea 1 Dual incision in TC-NER 1 Q9NR33,Q9NRF9,Q07864 197 8.49e-05 357 3 3 1.000 0.008 GO:0044454 CC 1 nuclear chromosome part 1 Q9NR33,Q9NRF9,Q07864 197 9.13e-05 38 3 2 0.667 0.053 GO:1902562 CC 1 H4 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 197 1.05e-04 383 3 3 1.000 0.008 GO:0000228 CC 1 nuclear chromosome 1 Q9NR33,Q9NRF9,Q07864 197 1.35e-04 77 3 3 1.000 0.039 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 Q9NR33,Q9NRF9,Q07864 197 1.40e-04 78 3 3 1.000 0.038 REAC:73886 rea 1 Chromosome Maintenance 1 Q9NR33,Q9NRF9,Q07864 197 1.47e-04 151 3 3 1.000 0.020 KEGG:00230 keg 1 Purine metabolism 1 Q9NR33,Q9NRF9,Q07864 197 1.65e-04 51 3 2 0.667 0.039 GO:0043966 BP 1 histone H3 acetylation 1 Q9NR33,Q9NRF9 197 1.69e-04 83 3 3 1.000 0.036 REAC:68874 rea 1 M/G1 Transition 1 Q9NR33,Q9NRF9,Q07864 197 1.69e-04 83 3 3 1.000 0.036 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 Q9NR33,Q9NRF9,Q07864 197 1.69e-04 83 3 3 1.000 0.036 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 Q9NR33,Q9NRF9,Q07864 197 2.89e-04 99 3 3 1.000 0.030 REAC:69239 rea 1 Synthesis of DNA 1 Q9NR33,Q9NRF9,Q07864 197 3.36e-04 104 3 3 1.000 0.029 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q9NR33,Q9NRF9,Q07864 197 3.37e-04 565 3 3 1.000 0.005 GO:0044427 CC 1 chromosomal part 1 Q9NR33,Q9NRF9,Q07864 197 3.56e-04 106 3 3 1.000 0.028 REAC:69306 rea 1 DNA Replication 1 Q9NR33,Q9NRF9,Q07864 197 3.87e-04 109 3 3 1.000 0.028 REAC:5696398 rea 1 Nucleotide Excision Repair 1 Q9NR33,Q9NRF9,Q07864 197 3.98e-04 110 3 3 1.000 0.027 REAC:5693538 rea 1 Homology Directed Repair 1 Q9NR33,Q9NRF9,Q07864 197 4.20e-04 81 3 2 0.667 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 197 4.23e-04 609 3 3 1.000 0.005 GO:0005694 CC 1 chromosome 1 Q9NR33,Q9NRF9,Q07864 197 4.45e-04 218 3 3 1.000 0.014 KEGG:05166 keg 1 HTLV-I infection 1 Q9NR33,Q9NRF9,Q07864 197 4.55e-04 624 3 3 1.000 0.005 GO:1990234 CC 1 transferase complex 1 Q9NR33,Q9NRF9,Q07864 197 4.55e-04 115 3 3 1.000 0.026 REAC:69206 rea 1 G1/S Transition 1 Q9NR33,Q9NRF9,Q07864 197 5.30e-04 91 3 2 0.667 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q9NR33,Q9NRF9 197 5.30e-04 91 3 2 0.667 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q9NR33,Q9NRF9 197 6.00e-04 126 3 3 1.000 0.024 REAC:69242 rea 1 S Phase 1 Q9NR33,Q9NRF9,Q07864 197 6.80e-04 103 3 2 0.667 0.019 GO:0016573 BP 1 histone acetylation 1 Q9NR33,Q9NRF9 197 7.06e-04 105 3 2 0.667 0.019 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 197 7.34e-04 107 3 2 0.667 0.019 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 197 7.73e-04 137 3 3 1.000 0.022 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 Q9NR33,Q9NRF9,Q07864 197 7.75e-04 110 3 2 0.667 0.018 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q9NR33,Q9NRF9 197 7.90e-04 138 3 3 1.000 0.022 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 Q9NR33,Q9NRF9,Q07864 197 8.06e-04 755 3 3 1.000 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q9NR33,Q9NRF9,Q07864 197 1.03e-03 127 3 2 0.667 0.016 GO:0006473 BP 1 protein acetylation 1 Q9NR33,Q9NRF9 197 1.40e-03 148 3 2 0.667 0.014 GO:0043543 BP 1 protein acylation 1 Q9NR33,Q9NRF9 197 1.74e-03 1 3 1 0.333 1.000 OMIM:615083 omi 1 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12;;COLORECTAL CANCER, SUSCEPTIBILITY TO, ON CHROMOSOME 12q24 1 Q07864 197 1.74e-03 1 3 1 0.333 1.000 OMIM:615139 omi 1 FACIAL DYSMORPHISM, IMMUNODEFICIENCY, LIVEDO, AND SHORT STATURE; FILS 1 Q07864 197 2.07e-03 1033 3 3 1.000 0.003 GO:1902494 CC 1 catalytic complex 1 Q9NR33,Q9NRF9,Q07864 197 2.25e-03 3 3 1 0.333 0.333 GO:0006287 BP 1 base-excision repair, gap-filling 1 Q07864 197 3.01e-03 217 3 2 0.667 0.009 GO:0006260 BP 1 DNA replication 1 Q9NRF9,Q07864 197 3.23e-03 372 3 2 0.667 0.005 MI:hsa-miR-22* mi 1 MI:hsa-miR-22* 1 Q9NR33,Q9NRF9 197 5.04e-03 281 3 2 0.667 0.007 GO:0016570 BP 1 histone modification 1 Q9NR33,Q9NRF9 197 5.13e-03 470 3 2 0.667 0.004 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 Q9NR33,Q9NRF9 197 5.36e-03 290 3 2 0.667 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q9NR33,Q9NRF9 197 5.59e-03 296 3 2 0.667 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9NR33,Q9NRF9 197 6.11e-03 272 3 3 1.000 0.011 REAC:73894 rea 1 DNA Repair 1 Q9NR33,Q9NRF9,Q07864 197 9.47e-03 1715 3 3 1.000 0.002 GO:0016740 MF 1 transferase activity 1 Q9NR33,Q9NRF9,Q07864 197 1.28e-02 449 3 2 0.667 0.004 GO:0006325 BP 1 chromatin organization 1 Q9NR33,Q9NRF9 197 1.41e-02 1960 3 3 1.000 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9NR33,Q9NRF9,Q07864 197 1.41e-02 1960 3 3 1.000 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9NR33,Q9NRF9,Q07864 197 1.54e-02 4 3 1 0.333 0.250 CORUM:234 cor 1 HuCHRAC complex 1 Q9NRF9 197 1.71e-02 521 3 2 0.667 0.004 GO:0044451 CC 1 nucleoplasm part 1 Q9NR33,Q9NRF9 197 1.72e-02 23 3 1 0.333 0.043 GO:0006297 BP 1 nucleotide-excision repair, DNA gap filling 1 Q07864 197 1.73e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 Q9NR33,Q9NRF9,Q07864 197 2.25e-02 30 3 1 0.333 0.033 GO:0006270 BP 1 DNA replication initiation 1 Q07864 197 2.32e-02 31 3 1 0.333 0.032 GO:0000722 BP 1 telomere maintenance via recombination 1 Q07864 197 2.40e-02 32 3 1 0.333 0.031 GO:0006284 BP 1 base-excision repair 1 Q07864 197 2.50e-02 322 3 2 0.667 0.006 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q9NR33,Q9NRF9 197 2.74e-02 448 3 3 1.000 0.007 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q9NR33,Q9NRF9,Q07864 197 2.80e-02 670 3 2 0.667 0.003 GO:0006259 BP 1 DNA metabolic process 1 Q9NRF9,Q07864 197 2.82e-02 342 3 2 0.667 0.006 TF:M04131_0 tf 1 Factor: TBX21; motif: AAGGTGTGAA; match class: 0 1 Q9NR33,Q9NRF9 197 3.04e-02 2529 3 3 1.000 0.001 GO:0005654 CC 1 nucleoplasm 1 Q9NR33,Q9NRF9,Q07864 197 3.22e-02 43 3 1 0.333 0.023 GO:0006312 BP 1 mitotic recombination 1 Q07864 197 3.23e-02 720 3 2 0.667 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9NR33,Q9NRF9 197 4.37e-02 14 3 1 0.333 0.071 TF:M06771_0 tf 1 Factor: ZNF228; motif: NGGACTGTGTCC; match class: 0 1 Q07864 197 4.37e-02 14 3 1 0.333 0.071 TF:M01043_1 tf 1 Factor: Nkx2-5; motif: TSYCACTTSM; match class: 1 1 Q9NRF9 197 4.73e-02 2931 3 3 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 Q9NR33,Q9NRF9,Q07864 197 5.00e-02 13 3 1 0.333 0.077 CORUM:1005 cor 1 RC complex during G2/M-phase of cell cycle 1 Q07864 197 5.00e-02 547 3 3 1.000 0.005 REAC:1640170 rea 1 Cell Cycle 1 Q9NR33,Q9NRF9,Q07864 197 5.00e-02 1048 3 3 1.000 0.003 KEGG:01100 keg 1 Metabolic pathways 1 Q9NR33,Q9NRF9,Q07864 197 5.00e-02 67 3 1 0.333 0.015 GO:0000731 BP 1 DNA synthesis involved in DNA repair 1 Q07864 197 5.00e-02 457 3 2 0.667 0.004 TF:M04240_1 tf 1 Factor: FOXD3; motif: NRNWAATATTKACN; match class: 1 1 Q9NR33,Q9NRF9 197 5.00e-02 29 3 1 0.333 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 Q07864 197 5.00e-02 13 3 1 0.333 0.077 CORUM:1004 cor 1 RC complex during S-phase of cell cycle 1 Q07864 197 5.00e-02 1 3 1 0.333 1.000 HP:0007421 hp 1 Telangiectases of the cheeks 1 Q07864 198 6.63e-05 24 3 2 0.667 0.083 GO:0030173 CC 1 integral component of Golgi membrane 1 Q5BJH7,O95070 198 9.07e-05 28 3 2 0.667 0.071 GO:0031228 CC 1 intrinsic component of Golgi membrane 1 Q5BJH7,O95070 198 3.43e-04 54 3 2 0.667 0.037 GO:0030134 CC 1 ER to Golgi transport vesicle 1 Q5BJH7,O95070 198 4.53e-04 62 3 2 0.667 0.032 GO:0005793 CC 1 endoplasmic reticulum-Golgi intermediate compartment 1 Q5BJH7,O95070 198 8.75e-04 86 3 2 0.667 0.023 GO:0031301 CC 1 integral component of organelle membrane 1 Q5BJH7,O95070 198 1.05e-03 94 3 2 0.667 0.021 GO:0031300 CC 1 intrinsic component of organelle membrane 1 Q5BJH7,O95070 198 2.77e-03 153 3 2 0.667 0.013 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 Q5BJH7,O95070 198 3.03e-03 160 3 2 0.667 0.013 GO:0030135 CC 1 coated vesicle 1 Q5BJH7,O95070 198 3.30e-03 376 3 2 0.667 0.005 MI:hsa-miR-92a-1* mi 1 MI:hsa-miR-92a-1* 1 Q5BJH7,O95070 198 3.40e-03 382 3 2 0.667 0.005 MI:mmu-miR-676 mi 1 MI:mmu-miR-676 1 Q5BJH7,O95070 198 4.36e-03 192 3 2 0.667 0.010 GO:0030133 CC 1 transport vesicle 1 Q5BJH7,O95070 198 9.11e-03 278 3 2 0.667 0.007 GO:0048193 BP 1 Golgi vesicle transport 1 Q5BJH7,O95070 198 1.30e-02 332 3 2 0.667 0.006 GO:0000139 CC 1 Golgi membrane 1 Q5BJH7,O95070 198 2.71e-02 482 3 2 0.667 0.004 GO:0044431 CC 1 Golgi apparatus part 1 Q5BJH7,O95070 198 3.24e-02 528 3 2 0.667 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q5BJH7,O95070 198 3.32e-02 534 3 2 0.667 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q5BJH7,O95070 198 4.81e-02 49 3 1 0.333 0.020 REAC:381038 rea 1 XBP1(S) activates chaperone genes 1 O95070 198 5.00e-02 9 3 1 0.333 0.111 TF:M01234_1 tf 1 Factor: ipf1; motif: AVCTAATGAG; match class: 1 1 Q969M3 198 5.00e-02 9 3 1 0.333 0.111 TF:M06572_0 tf 1 Factor: ZNF597; motif: KGGTAATTGAGA; match class: 0 1 Q969M3 198 5.00e-02 658 3 2 0.667 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 Q5BJH7,O95070 198 5.00e-02 51 3 1 0.333 0.020 REAC:381070 rea 1 IRE1alpha activates chaperones 1 O95070 199 9.24e-07 37 5 3 0.600 0.081 GO:0007565 BP 1 female pregnancy 1 Q12816,O95467,Q9UNF1 199 1.27e-06 41 5 3 0.600 0.073 GO:0044706 BP 1 multi-multicellular organism process 1 Q12816,O95467,Q9UNF1 199 1.28e-05 8 5 2 0.400 0.250 GO:0007191 BP 1 adenylate cyclase-activating dopamine receptor signaling pathway 1 O95467,P38405 199 1.06e-04 22 5 2 0.400 0.091 GO:0007190 BP 1 activation of adenylate cyclase activity 1 O95467,P38405 199 1.16e-04 23 5 2 0.400 0.087 GO:0045762 BP 1 positive regulation of adenylate cyclase activity 1 O95467,P38405 199 1.26e-04 24 5 2 0.400 0.083 GO:0007212 BP 1 dopamine receptor signaling pathway 1 O95467,P38405 199 1.86e-04 29 5 2 0.400 0.069 GO:0031281 BP 1 positive regulation of cyclase activity 1 O95467,P38405 199 1.86e-04 29 5 2 0.400 0.069 GO:0051349 BP 1 positive regulation of lyase activity 1 O95467,P38405 199 1.99e-04 30 5 2 0.400 0.067 GO:0030819 BP 1 positive regulation of cAMP biosynthetic process 1 O95467,P38405 199 2.12e-04 31 5 2 0.400 0.065 GO:0030816 BP 1 positive regulation of cAMP metabolic process 1 O95467,P38405 199 2.27e-04 32 5 2 0.400 0.062 GO:0045761 BP 1 regulation of adenylate cyclase activity 1 O95467,P38405 199 2.56e-04 34 5 2 0.400 0.059 GO:0030804 BP 1 positive regulation of cyclic nucleotide biosynthetic process 1 O95467,P38405 199 2.64e-04 240 5 3 0.600 0.013 GO:0044703 BP 1 multi-organism reproductive process 1 Q12816,O95467,Q9UNF1 199 2.88e-04 36 5 2 0.400 0.056 GO:0030810 BP 1 positive regulation of nucleotide biosynthetic process 1 O95467,P38405 199 2.88e-04 36 5 2 0.400 0.056 GO:1900373 BP 1 positive regulation of purine nucleotide biosynthetic process 1 O95467,P38405 199 3.04e-04 37 5 2 0.400 0.054 GO:0030801 BP 1 positive regulation of cyclic nucleotide metabolic process 1 O95467,P38405 199 3.21e-04 38 5 2 0.400 0.053 GO:0031279 BP 1 regulation of cyclase activity 1 O95467,P38405 199 3.38e-04 39 5 2 0.400 0.051 GO:0007608 BP 1 sensory perception of smell 1 O95467,P38405 199 3.56e-04 40 5 2 0.400 0.050 GO:0007189 BP 1 adenylate cyclase-activating G-protein coupled receptor signaling pathway 1 O95467,P38405 199 3.56e-04 40 5 2 0.400 0.050 GO:0051339 BP 1 regulation of lyase activity 1 O95467,P38405 199 4.12e-04 43 5 2 0.400 0.047 GO:0030817 BP 1 regulation of cAMP biosynthetic process 1 O95467,P38405 199 4.31e-04 44 5 2 0.400 0.045 GO:0006171 BP 1 cAMP biosynthetic process 1 O95467,P38405 199 4.93e-04 47 5 2 0.400 0.043 GO:0030802 BP 1 regulation of cyclic nucleotide biosynthetic process 1 O95467,P38405 199 5.14e-04 48 5 2 0.400 0.042 GO:0030814 BP 1 regulation of cAMP metabolic process 1 O95467,P38405 199 5.36e-04 49 5 2 0.400 0.041 GO:1900544 BP 1 positive regulation of purine nucleotide metabolic process 1 O95467,P38405 199 5.36e-04 49 5 2 0.400 0.041 GO:0045981 BP 1 positive regulation of nucleotide metabolic process 1 O95467,P38405 199 5.81e-04 51 5 2 0.400 0.039 GO:1900371 BP 1 regulation of purine nucleotide biosynthetic process 1 O95467,P38405 199 6.04e-04 52 5 2 0.400 0.038 GO:0030808 BP 1 regulation of nucleotide biosynthetic process 1 O95467,P38405 199 6.51e-04 54 5 2 0.400 0.037 GO:0052652 BP 1 cyclic purine nucleotide metabolic process 1 O95467,P38405 199 6.76e-04 55 5 2 0.400 0.036 GO:0003014 BP 1 renal system process 1 O95467,Q9UNF1 199 6.76e-04 55 5 2 0.400 0.036 GO:0009190 BP 1 cyclic nucleotide biosynthetic process 1 O95467,P38405 199 7.01e-04 56 5 2 0.400 0.036 GO:0046058 BP 1 cAMP metabolic process 1 O95467,P38405 199 7.01e-04 56 5 2 0.400 0.036 GO:0030799 BP 1 regulation of cyclic nucleotide metabolic process 1 O95467,P38405 199 1.10e-03 388 5 3 0.600 0.008 GO:0022414 BP 1 reproductive process 1 Q12816,O95467,Q9UNF1 199 1.11e-03 389 5 3 0.600 0.008 GO:0000003 BP 1 reproduction 1 Q12816,O95467,Q9UNF1 199 1.19e-03 73 5 2 0.400 0.027 GO:0007188 BP 1 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 1 O95467,P38405 199 1.26e-03 75 5 2 0.400 0.027 GO:0007606 BP 1 sensory perception of chemical stimulus 1 O95467,P38405 199 1.26e-03 75 5 2 0.400 0.027 GO:0009187 BP 1 cyclic nucleotide metabolic process 1 O95467,P38405 199 1.33e-03 77 5 2 0.400 0.026 GO:0007187 BP 1 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1 O95467,P38405 199 1.69e-03 87 5 2 0.400 0.023 GO:1900542 BP 1 regulation of purine nucleotide metabolic process 1 O95467,P38405 199 2.02e-03 95 5 2 0.400 0.021 GO:0006140 BP 1 regulation of nucleotide metabolic process 1 O95467,P38405 199 2.65e-03 2 5 1 0.200 0.500 GO:0051429 MF 1 corticotropin-releasing hormone receptor binding 1 O95467 199 2.65e-03 2 5 1 0.200 0.500 GO:0031852 MF 1 mu-type opioid receptor binding 1 O95467 199 2.65e-03 2 5 1 0.200 0.500 GO:0071107 BP 1 response to parathyroid hormone 1 O95467 199 2.65e-03 2 5 1 0.200 0.500 GO:0051430 MF 1 corticotropin-releasing hormone receptor 1 binding 1 O95467 199 2.75e-03 111 5 2 0.400 0.018 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 O95467,P38405 199 2.90e-03 114 5 2 0.400 0.018 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 O95467,P38405 199 2.95e-03 115 5 2 0.400 0.017 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 O95467,P38405 199 3.00e-03 116 5 2 0.400 0.017 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 O95467,P38405 199 3.65e-03 128 5 2 0.400 0.016 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 O95467,P38405 199 3.97e-03 3 5 1 0.200 0.333 GO:0060789 BP 1 hair follicle placode formation 1 O95467 199 3.97e-03 3 5 1 0.200 0.333 GO:0031748 MF 1 D1 dopamine receptor binding 1 O95467 199 3.97e-03 3 5 1 0.200 0.333 GO:0043950 BP 1 positive regulation of cAMP-mediated signaling 1 O95467 199 3.97e-03 3 5 1 0.200 0.333 GO:0040015 BP 1 negative regulation of multicellular organism growth 1 O95467 199 4.00e-03 134 5 2 0.400 0.015 GO:0009165 BP 1 nucleotide biosynthetic process 1 O95467,P38405 199 4.87e-03 148 5 2 0.400 0.014 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 O95467,P38405 199 4.99e-03 650 5 3 0.600 0.005 GO:0051704 BP 1 multi-organism process 1 Q12816,O95467,Q9UNF1 199 5.29e-03 4 5 1 0.200 0.250 GO:0031698 MF 1 beta-2 adrenergic receptor binding 1 O95467 199 5.29e-03 4 5 1 0.200 0.250 GO:0031628 MF 1 opioid receptor binding 1 O95467 199 5.29e-03 4 5 1 0.200 0.250 GO:0003096 BP 1 renal sodium ion transport 1 Q9UNF1 199 5.29e-03 4 5 1 0.200 0.250 GO:0070294 BP 1 renal sodium ion absorption 1 Q9UNF1 199 5.54e-03 158 5 2 0.400 0.013 GO:0003924 MF 1 GTPase activity 1 O95467,P38405 199 6.02e-03 693 5 3 0.600 0.004 GO:0003008 BP 1 system process 1 O95467,Q9UNF1,P38405 199 6.62e-03 5 5 1 0.200 0.200 GO:0050780 MF 1 dopamine receptor binding 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0071696 BP 1 ectodermal placode development 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0071855 MF 1 neuropeptide receptor binding 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0071380 BP 1 cellular response to prostaglandin E stimulus 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0071697 BP 1 ectodermal placode morphogenesis 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0051428 MF 1 peptide hormone receptor binding 1 O95467 199 6.62e-03 5 5 1 0.200 0.200 GO:0060788 BP 1 ectodermal placode formation 1 O95467 199 7.94e-03 6 5 1 0.200 0.167 GO:0034695 BP 1 response to prostaglandin E 1 O95467 199 9.26e-03 7 5 1 0.200 0.143 GO:0035255 MF 1 ionotropic glutamate receptor binding 1 O95467 199 1.03e-02 216 5 2 0.400 0.009 GO:0007600 BP 1 sensory perception 1 O95467,P38405 199 1.06e-02 8 5 1 0.200 0.125 GO:0071379 BP 1 cellular response to prostaglandin stimulus 1 O95467 199 1.19e-02 9 5 1 0.200 0.111 GO:0034694 BP 1 response to prostaglandin 1 O95467 199 1.19e-02 9 5 1 0.200 0.111 GO:0005159 MF 1 insulin-like growth factor receptor binding 1 O95467 199 1.32e-02 10 5 1 0.200 0.100 GO:0043949 BP 1 regulation of cAMP-mediated signaling 1 O95467 199 1.32e-02 10 5 1 0.200 0.100 GO:0071880 BP 1 adenylate cyclase-activating adrenergic receptor signaling pathway 1 O95467 199 1.32e-02 10 5 1 0.200 0.100 GO:0007566 BP 1 embryo implantation 1 Q12816 199 1.45e-02 11 5 1 0.200 0.091 GO:0070293 BP 1 renal absorption 1 Q9UNF1 199 1.45e-02 11 5 1 0.200 0.091 GO:0040014 BP 1 regulation of multicellular organism growth 1 O95467 199 1.48e-02 10 5 1 0.200 0.100 REAC:170660 rea 1 Adenylate cyclase activating pathway 1 P38405 199 1.59e-02 12 5 1 0.200 0.083 GO:0035264 BP 1 multicellular organism growth 1 O95467 199 1.72e-02 13 5 1 0.200 0.077 GO:0035254 MF 1 glutamate receptor binding 1 O95467 199 1.85e-02 14 5 1 0.200 0.071 GO:0071875 BP 1 adrenergic receptor signaling pathway 1 O95467 199 1.85e-02 14 5 1 0.200 0.071 GO:0031690 MF 1 adrenergic receptor binding 1 O95467 199 1.85e-02 14 5 1 0.200 0.071 GO:0071398 BP 1 cellular response to fatty acid 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0005834 CC 1 heterotrimeric G-protein complex 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:1905360 CC 1 GTPase complex 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0001942 BP 1 hair follicle development 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0098773 BP 1 skin epidermis development 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0022405 BP 1 hair cycle process 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0022404 BP 1 molting cycle process 1 O95467 199 1.98e-02 15 5 1 0.200 0.067 GO:0070542 BP 1 response to fatty acid 1 O95467 199 1.99e-02 303 5 2 0.400 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 O95467,P38405 199 2.05e-02 307 5 2 0.400 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 O95467,P38405 199 2.07e-02 14 5 1 0.200 0.071 REAC:170670 rea 1 Adenylate cyclase inhibitory pathway 1 P38405 199 2.07e-02 14 5 1 0.200 0.071 REAC:997269 rea 1 Inhibition of adenylate cyclase pathway 1 P38405 199 2.20e-02 319 5 2 0.400 0.006 GO:0019693 BP 1 ribose phosphate metabolic process 1 O95467,P38405 199 2.25e-02 17 5 1 0.200 0.059 GO:0071869 BP 1 response to catecholamine 1 O95467 199 2.25e-02 17 5 1 0.200 0.059 GO:0071867 BP 1 response to monoamine 1 O95467 199 2.25e-02 17 5 1 0.200 0.059 GO:0071870 BP 1 cellular response to catecholamine stimulus 1 O95467 199 2.25e-02 17 5 1 0.200 0.059 GO:0071868 BP 1 cellular response to monoamine stimulus 1 O95467 199 2.27e-02 324 5 2 0.400 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 O95467,P38405 199 2.30e-02 326 5 2 0.400 0.006 GO:0050877 BP 1 neurological system process 1 O95467,P38405 199 2.36e-02 16 5 1 0.200 0.062 REAC:392851 rea 1 Prostacyclin signalling through prostacyclin receptor 1 O95467 199 2.41e-02 334 5 2 0.400 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 O95467,P38405 199 2.50e-02 1 5 1 0.200 1.000 HP:0005605 hp 1 Large cafe-au-lait macules with irregular margins 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 HP:0010734 hp 1 Fibrous dysplasia of the bones 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 HP:0010735 hp 1 Polyostotic fibrous dysplasia 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 HP:0003472 hp 1 Hypocalcemic tetany 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 OMIM:166350 omi 1 OSSEOUS HETEROPLASIA, PROGRESSIVE; POH;;ECTOPIC OSSIFICATION, FAMILIAL;;OSTEOMA CUTIS 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 OMIM:612463 omi 1 PSEUDOPSEUDOHYPOPARATHYROIDISM; PPHP;;ALBRIGHT HEREDITARY OSTEODYSTROPHY WITHOUT MULTIPLE HORMONE RESISTANCE 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 OMIM:612462 omi 1 PSEUDOHYPOPARATHYROIDISM, TYPE IC; PHP1C;;PHP IC 1 O95467 199 2.50e-02 1 5 1 0.200 1.000 OMIM:615073 omi 1 DYSTONIA 25; DYT25 1 P38405 199 2.50e-02 1 5 1 0.200 1.000 OMIM:103580 omi 1 PSEUDOHYPOPARATHYROIDISM, TYPE IA; PHP1A;;PHP IA;;ALBRIGHT HEREDITARY OSTEODYSTROPHY WITH MULTIPLE HORMONE RESISTANCE 1 O95467 199 2.51e-02 19 5 1 0.200 0.053 GO:1901655 BP 1 cellular response to ketone 1 O95467 199 2.51e-02 17 5 1 0.200 0.059 REAC:420092 rea 1 Glucagon-type ligand receptors 1 O95467 199 2.51e-02 17 5 1 0.200 0.059 REAC:164378 rea 1 PKA activation in glucagon signalling 1 O95467 199 2.64e-02 350 5 2 0.400 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 O95467,P38405 199 2.74e-02 357 5 2 0.400 0.006 GO:0007186 BP 1 G-protein coupled receptor signaling pathway 1 O95467,P38405 199 2.77e-02 21 5 1 0.200 0.048 GO:0042633 BP 1 hair cycle 1 O95467 199 2.77e-02 21 5 1 0.200 0.048 GO:0042303 BP 1 molting cycle 1 O95467 199 3.08e-02 4600 5 5 1.000 0.001 GO:0016020 CC 1 membrane 1 Q12816,O95467,Q9UNF1,Q9NX40,P38405 199 3.22e-02 388 5 2 0.400 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 O95467,P38405 199 3.24e-02 389 5 2 0.400 0.005 GO:0098609 BP 1 cell-cell adhesion 1 Q12816,O95467 199 3.30e-02 25 5 1 0.200 0.040 GO:0003091 BP 1 renal water homeostasis 1 O95467 199 3.39e-02 398 5 2 0.400 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 O95467,P38405 199 3.64e-02 463 5 3 0.600 0.006 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 Q12816,O95467,P38405 199 3.97e-02 477 5 3 0.600 0.006 MI:hsa-miR-489 mi 1 MI:hsa-miR-489 1 Q12816,O95467,Q9UNF1 199 4.08e-02 31 5 1 0.200 0.032 GO:0071377 BP 1 cellular response to glucagon stimulus 1 O95467 199 4.08e-02 31 5 1 0.200 0.032 GO:0019933 BP 1 cAMP-mediated signaling 1 O95467 199 4.27e-02 29 5 1 0.200 0.034 REAC:991365 rea 1 Activation of GABAB receptors 1 P38405 199 4.27e-02 29 5 1 0.200 0.034 REAC:977444 rea 1 GABA B receptor activation 1 P38405 199 4.29e-02 450 5 2 0.400 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 O95467,P38405 199 4.35e-02 33 5 1 0.200 0.030 GO:1901654 BP 1 response to ketone 1 O95467 199 4.35e-02 33 5 1 0.200 0.030 GO:0033762 BP 1 response to glucagon 1 O95467 199 4.36e-02 342 5 2 0.400 0.006 REAC:388396 rea 1 GPCR downstream signaling 1 O95467,P38405 199 4.41e-02 76 5 2 0.400 0.026 KEGG:05146 keg 1 Amoebiasis 1 O95467,P38405 199 4.48e-02 34 5 1 0.200 0.029 GO:0007156 BP 1 homophilic cell adhesion via plasma membrane adhesion molecules 1 Q12816 199 4.56e-02 31 5 1 0.200 0.032 REAC:163359 rea 1 Glucagon signaling in metabolic regulation 1 O95467 199 4.59e-02 466 5 2 0.400 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 O95467,P38405 199 4.61e-02 35 5 1 0.200 0.029 GO:0007193 BP 1 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 1 P38405 199 4.74e-02 36 5 1 0.200 0.028 GO:0019935 BP 1 cyclic-nucleotide-mediated signaling 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 OMIM:219080 omi 1 ACTH-Independent Macronodular Adrenal Hyperplasia 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 HP:0100829 hp 1 Galactorrhea 1 O95467 199 5.00e-02 38 5 1 0.200 0.026 GO:0050891 BP 1 multicellular organismal water homeostasis 1 O95467 199 5.00e-02 81 5 2 0.400 0.025 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 O95467,P38405 199 5.00e-02 2 5 1 0.200 0.500 HP:0006960 hp 1 Choroid plexus calcification 1 O95467 199 5.00e-02 3 5 1 0.200 0.333 CORUM:1612 cor 1 Heterotrimeric G protein complex (GNG2, GNB1, GNAS) 1 O95467 199 5.00e-02 51 5 2 0.400 0.039 TF:M04059_1 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 1 1 Q12816,Q9UNF1 199 5.00e-02 2 5 1 0.200 0.500 HP:0008231 hp 1 Macronodular adrenal hyperplasia 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 HP:0100246 hp 1 Osteoma 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 HP:0011760 hp 1 Pituitary growth hormone cell adenoma 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 OMIM:102200 omi 1 Growth Hormone-Secreting Pituitary Adenomas 1 O95467 199 5.00e-02 51 5 2 0.400 0.039 TF:M04059_0 tf 1 Factor: NRF1; motif: YGCGCATGCGCN; match class: 0 1 Q12816,Q9UNF1 199 5.00e-02 38 5 1 0.200 0.026 GO:0048640 BP 1 negative regulation of developmental growth 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 OMIM:603233 omi 1 PSEUDOHYPOPARATHYROIDISM, TYPE IB; PHP1B;;PHP IB 1 O95467 199 5.00e-02 1462 5 4 0.800 0.003 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 Q12816,Q9UNF1,Q9NX40,P38405 199 5.00e-02 2 5 1 0.200 0.500 HP:0000852 hp 1 Pseudohypoparathyroidism 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 HP:0000870 hp 1 Prolactin excess 1 O95467 199 5.00e-02 34 5 1 0.200 0.029 REAC:381676 rea 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 O95467 199 5.00e-02 2 5 1 0.200 0.500 HP:0003456 hp 1 Low urinary cyclic AMP response to PTH administration 1 O95467 199 5.00e-02 516 5 3 0.600 0.006 MI:hsa-miR-96 mi 1 MI:hsa-miR-96 1 Q12816,Q9UNF1,Q9NX40 200 1.41e-03 6 3 1 0.333 0.167 TF:M04266_0 tf 1 Factor: FOXO6; motif: TTTCCCCACACGAC; match class: 0 1 P50747 200 2.12e-03 9 3 1 0.333 0.111 TF:M02242_1 tf 1 Factor: CTCF; motif: YNRCCASYAGRKGGCRSYN; match class: 1 1 P50747 200 3.53e-03 15 3 1 0.333 0.067 TF:M07335_1 tf 1 Factor: Six-1; motif: CTCAGVTTTCT; match class: 1 1 Q14C86 200 3.85e-03 1 3 1 0.333 1.000 GO:0009305 BP 1 protein biotinylation 1 P50747 200 3.85e-03 1 3 1 0.333 1.000 GO:0071110 BP 1 histone biotinylation 1 P50747 200 3.85e-03 1 3 1 0.333 1.000 GO:0004080 MF 1 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity 1 P50747 200 3.85e-03 1 3 1 0.333 1.000 GO:0018271 MF 1 biotin-protein ligase activity 1 P50747 200 3.85e-03 1 3 1 0.333 1.000 GO:0070781 BP 1 response to biotin 1 P50747 200 5.63e-03 493 3 2 0.667 0.004 MI:hsa-miR-574-5p mi 1 MI:hsa-miR-574-5p 1 Q14C86,Q5T0L3 200 5.65e-03 24 3 1 0.333 0.042 TF:M06699_0 tf 1 Factor: ZNF226; motif: NWAGTGGAAAGM; match class: 0 1 Q14C86 200 7.31e-03 2471 3 3 1.000 0.001 TF:M04224_1 tf 1 Factor: NRL; motif: NNNNTGCTGAC; match class: 1 1 P50747,Q14C86,Q5T0L3 200 9.87e-03 42 3 1 0.333 0.024 TF:M05410_0 tf 1 Factor: ZSCAN1; motif: GGGKACAYKAGGC; match class: 0 1 Q5T0L3 200 1.06e-02 45 3 1 0.333 0.022 TF:M01259_1 tf 1 Factor: CTCF; motif: NNNNNNCCASNAGRKGGCRS; match class: 1 1 P50747 200 1.10e-02 47 3 1 0.333 0.021 TF:M06484_0 tf 1 Factor: ZNF683; motif: TTCCYAAATGC; match class: 0 1 P50747 200 1.20e-02 51 3 1 0.333 0.020 TF:M06981_0 tf 1 Factor: PRDM12; motif: NGACAGNTKACC; match class: 0 1 Q5T0L3 200 1.54e-02 4 3 1 0.333 0.250 GO:0009374 MF 1 biotin binding 1 P50747 200 1.54e-02 4 3 1 0.333 0.250 GO:0005652 CC 1 nuclear lamina 1 P50747 200 1.65e-02 3240 3 3 1.000 0.001 TF:M04635_1 tf 1 Factor: TEF-5; motif: AAAAATAT; match class: 1 1 P50747,Q14C86,Q5T0L3 200 1.83e-02 78 3 1 0.333 0.013 TF:M06741_0 tf 1 Factor: ZNF70; motif: NGGWCAAAAAGM; match class: 0 1 Q5T0L3 200 1.90e-02 81 3 1 0.333 0.012 TF:M06313_0 tf 1 Factor: ZNF678; motif: KGTTAAAAGAGA; match class: 0 1 P50747 200 2.11e-02 13 3 1 0.333 0.077 HP:0100825 hp 1 Cheilitis 1 P50747 200 2.43e-02 104 3 1 0.333 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 Q14C86 200 2.52e-02 108 3 1 0.333 0.009 TF:M07049_1 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 1 1 Q14C86 200 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q14C86 200 2.69e-02 7 3 1 0.333 0.143 GO:0032794 MF 1 GTPase activating protein binding 1 Q14C86 200 2.78e-02 119 3 1 0.333 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 P50747 200 2.83e-02 121 3 1 0.333 0.008 TF:M00005_0 tf 1 Factor: AP-4; motif: WGARYCAGCTGYGGNCNK; match class: 0 1 Q5T0L3 200 3.09e-02 1339 3 2 0.667 0.001 TF:M00634_0 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 0 1 P50747,Q14C86 200 3.15e-02 135 3 1 0.333 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 Q14C86 200 3.19e-02 137 3 1 0.333 0.007 TF:M04352_1 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 1 1 Q14C86 200 3.26e-02 140 3 1 0.333 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q14C86 200 3.49e-02 4160 3 3 1.000 0.001 TF:M01722_1 tf 1 Factor: RORbeta; motif: TGACCYA; match class: 1 1 P50747,Q14C86,Q5T0L3 200 3.49e-02 150 3 1 0.333 0.007 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 P50747 200 3.53e-02 1437 3 2 0.667 0.001 TF:M01279_0 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 0 1 P50747,Q14C86 200 3.56e-02 1442 3 2 0.667 0.001 TF:M04470_0 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 0 1 P50747,Q5T0L3 200 3.59e-02 154 3 1 0.333 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 P50747 200 3.91e-02 168 3 1 0.333 0.006 TF:M06322_0 tf 1 Factor: ZNF181; motif: NCGGAAAGACGC; match class: 0 1 P50747 200 4.00e-02 172 3 1 0.333 0.006 TF:M04254_1 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 1 1 P50747 200 4.00e-02 172 3 1 0.333 0.006 TF:M00006_1 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 1 1 P50747 200 4.01e-02 4357 3 3 1.000 0.001 TF:M02028_0 tf 1 Factor: Pbx1; motif: ATCAATCAN; match class: 0 1 P50747,Q14C86,Q5T0L3 200 4.14e-02 178 3 1 0.333 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 P50747 200 4.37e-02 188 3 1 0.333 0.005 TF:M00406_1 tf 1 Factor: MEF-2A; motif: SKYTAAAAATAACYCH; match class: 1 1 P50747 200 4.41e-02 1614 3 2 0.667 0.001 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 P50747,Q14C86 200 4.53e-02 195 3 1 0.333 0.005 TF:M06390_0 tf 1 Factor: ZNF227; motif: RTTCKGAGATN; match class: 0 1 Q14C86 200 4.59e-02 1648 3 2 0.667 0.001 TF:M00252_1 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 1 1 P50747,Q5T0L3 200 4.61e-02 1652 3 2 0.667 0.001 TF:M03820_1 tf 1 Factor: ER-alpha; motif: GGNNNNNNTGACCYN; match class: 1 1 P50747,Q14C86 200 4.65e-02 1659 3 2 0.667 0.001 TF:M01013_0 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 0 1 P50747,Q5T0L3 200 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 P50747,Q14C86,Q5T0L3 200 4.78e-02 206 3 1 0.333 0.005 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 P50747 200 4.92e-02 4666 3 3 1.000 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 P50747,Q14C86,Q5T0L3 200 5.00e-02 3 3 1 0.333 0.333 KEGG:00780 keg 1 Biotin metabolism 1 P50747 200 5.00e-02 31 3 1 0.333 0.032 HP:0002789 hp 1 Tachypnea 1 P50747 200 5.00e-02 11 3 1 0.333 0.091 REAC:196780 rea 1 Biotin transport and metabolism 1 P50747 200 5.00e-02 1 3 1 0.333 1.000 OMIM:253270 omi 1 HOLOCARBOXYLASE SYNTHETASE DEFICIENCY;;HLCS DEFICIENCY;;MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL FORM;;MULTIPLE CARBOXYLASE DEFICIENCY, EARLY ONSET 1 P50747 201 4.11e-06 8 3 2 0.667 0.250 GO:1904871 BP 1 positive regulation of protein localization to Cajal body 1 P40227,P50990 201 4.11e-06 8 3 2 0.667 0.250 GO:1904869 BP 1 regulation of protein localization to Cajal body 1 P40227,P50990 201 4.11e-06 8 3 2 0.667 0.250 GO:0005832 CC 1 chaperonin-containing T-complex 1 P40227,P50990 201 5.28e-06 9 3 2 0.667 0.222 GO:1904851 BP 1 positive regulation of establishment of protein localization to telomere 1 P40227,P50990 201 5.28e-06 9 3 2 0.667 0.222 GO:1990173 BP 1 protein localization to nucleoplasm 1 P40227,P50990 201 5.28e-06 9 3 2 0.667 0.222 GO:1904867 BP 1 protein localization to Cajal body 1 P40227,P50990 201 5.28e-06 9 3 2 0.667 0.222 GO:1903405 BP 1 protein localization to nuclear body 1 P40227,P50990 201 6.60e-06 10 3 2 0.667 0.200 GO:0070202 BP 1 regulation of establishment of protein localization to chromosome 1 P40227,P50990 201 6.60e-06 10 3 2 0.667 0.200 GO:0070203 BP 1 regulation of establishment of protein localization to telomere 1 P40227,P50990 201 8.06e-06 11 3 2 0.667 0.182 GO:1904816 BP 1 positive regulation of protein localization to chromosome, telomeric region 1 P40227,P50990 201 1.14e-05 13 3 2 0.667 0.154 GO:1904814 BP 1 regulation of protein localization to chromosome, telomeric region 1 P40227,P50990 201 1.42e-05 10 3 2 0.667 0.200 REAC:390450 rea 1 Folding of actin by CCT/TriC 1 P40227,P50990 201 1.54e-05 15 3 2 0.667 0.133 GO:0070200 BP 1 establishment of protein localization to telomere 1 P40227,P50990 201 1.54e-05 15 3 2 0.667 0.133 GO:1904872 BP 1 regulation of telomerase RNA localization to Cajal body 1 P40227,P50990 201 1.54e-05 15 3 2 0.667 0.133 GO:1904874 BP 1 positive regulation of telomerase RNA localization to Cajal body 1 P40227,P50990 201 1.76e-05 16 3 2 0.667 0.125 GO:0090672 BP 1 telomerase RNA localization 1 P40227,P50990 201 1.76e-05 16 3 2 0.667 0.125 GO:0090670 BP 1 RNA localization to Cajal body 1 P40227,P50990 201 1.76e-05 16 3 2 0.667 0.125 GO:0090671 BP 1 telomerase RNA localization to Cajal body 1 P40227,P50990 201 3.38e-05 22 3 2 0.667 0.091 GO:0070199 BP 1 establishment of protein localization to chromosome 1 P40227,P50990 201 4.76e-05 26 3 2 0.667 0.077 GO:0070198 BP 1 protein localization to chromosome, telomeric region 1 P40227,P50990 201 5.54e-05 28 3 2 0.667 0.071 GO:0032212 BP 1 positive regulation of telomere maintenance via telomerase 1 P40227,P50990 201 5.95e-05 29 3 2 0.667 0.069 GO:1904358 BP 1 positive regulation of telomere maintenance via telomere lengthening 1 P40227,P50990 201 7.65e-05 8 3 2 0.667 0.250 CORUM:126 cor 1 CCT micro-complex 1 P40227,P50990 201 7.99e-05 23 3 2 0.667 0.087 REAC:389960 rea 1 Formation of tubulin folding intermediates by CCT/TriC 1 P40227,P50990 201 1.03e-04 26 3 2 0.667 0.077 REAC:389957 rea 1 Prefoldin mediated transfer of substrate to CCT/TriC 1 P40227,P50990 201 1.14e-04 40 3 2 0.667 0.050 GO:0032210 BP 1 regulation of telomere maintenance via telomerase 1 P40227,P50990 201 1.20e-04 41 3 2 0.667 0.049 GO:0032206 BP 1 positive regulation of telomere maintenance 1 P40227,P50990 201 1.37e-04 30 3 2 0.667 0.067 REAC:389958 rea 1 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1 P40227,P50990 201 1.38e-04 44 3 2 0.667 0.045 GO:1904356 BP 1 regulation of telomere maintenance via telomere lengthening 1 P40227,P50990 201 1.51e-04 46 3 2 0.667 0.043 GO:2000573 BP 1 positive regulation of DNA biosynthetic process 1 P40227,P50990 201 1.86e-04 51 3 2 0.667 0.039 GO:0007004 BP 1 telomere maintenance via telomerase 1 P40227,P50990 201 1.94e-04 52 3 2 0.667 0.038 GO:0006278 BP 1 RNA-dependent DNA biosynthetic process 1 P40227,P50990 201 2.10e-04 37 3 2 0.667 0.054 REAC:390471 rea 1 Association of TriC/CCT with target proteins during biosynthesis 1 P40227,P50990 201 2.10e-04 37 3 2 0.667 0.054 REAC:6814122 rea 1 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1 P40227,P50990 201 2.17e-04 55 3 2 0.667 0.036 GO:0034502 BP 1 protein localization to chromosome 1 P40227,P50990 201 2.25e-04 56 3 2 0.667 0.036 GO:0010833 BP 1 telomere maintenance via telomere lengthening 1 P40227,P50990 201 2.42e-04 58 3 2 0.667 0.034 GO:2001252 BP 1 positive regulation of chromosome organization 1 P40227,P50990 201 2.50e-04 59 3 2 0.667 0.034 GO:0032204 BP 1 regulation of telomere maintenance 1 P40227,P50990 201 3.43e-04 69 3 2 0.667 0.029 GO:2000278 BP 1 regulation of DNA biosynthetic process 1 P40227,P50990 201 3.73e-04 72 3 2 0.667 0.028 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 P40227,P50990 201 7.36e-04 101 3 2 0.667 0.020 GO:0032846 BP 1 positive regulation of homeostatic process 1 P40227,P50990 201 7.46e-04 707 3 3 1.000 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q14444,P40227,P50990 201 7.81e-04 104 3 2 0.667 0.019 GO:0050821 BP 1 protein stabilization 1 P40227,P50990 201 8.58e-04 109 3 2 0.667 0.018 GO:0000723 BP 1 telomere maintenance 1 P40227,P50990 201 8.74e-04 110 3 2 0.667 0.018 GO:0032200 BP 1 telomere organization 1 P40227,P50990 201 9.20e-04 540 3 3 1.000 0.006 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q14444,P40227,P50990 201 9.89e-04 117 3 2 0.667 0.017 GO:0033044 BP 1 regulation of chromosome organization 1 P40227,P50990 201 1.02e-03 119 3 2 0.667 0.017 GO:1900180 BP 1 regulation of protein localization to nucleus 1 P40227,P50990 201 1.15e-03 86 3 2 0.667 0.023 REAC:390466 rea 1 Chaperonin-mediated protein folding 1 P40227,P50990 201 1.18e-03 128 3 2 0.667 0.016 GO:0051054 BP 1 positive regulation of DNA metabolic process 1 P40227,P50990 201 1.31e-03 92 3 2 0.667 0.022 REAC:391251 rea 1 Protein folding 1 P40227,P50990 201 1.42e-03 140 3 2 0.667 0.014 GO:0071897 BP 1 DNA biosynthetic process 1 P40227,P50990 201 1.65e-03 7 3 1 0.333 0.143 TF:M05953_0 tf 1 Factor: CTIP-2; motif: NGAGGGAAACGC; match class: 0 1 Q14444 201 1.67e-03 152 3 2 0.667 0.013 GO:0006457 BP 1 protein folding 1 P40227,P50990 201 1.80e-03 158 3 2 0.667 0.013 GO:0006403 BP 1 RNA localization 1 P40227,P50990 201 1.89e-03 162 3 2 0.667 0.012 GO:0031647 BP 1 regulation of protein stability 1 P40227,P50990 201 1.99e-03 166 3 2 0.667 0.012 GO:0005874 CC 1 microtubule 1 P40227,P50990 201 2.54e-03 3 3 1 0.333 0.333 GO:0071987 MF 1 WD40-repeat domain binding 1 P40227 201 2.59e-03 11 3 1 0.333 0.091 TF:M06211_0 tf 1 Factor: ZNF33a; motif: NGGTAAAGCASM; match class: 0 1 P50990 201 2.59e-03 11 3 1 0.333 0.091 TF:M06212_0 tf 1 Factor: ZNF33b; motif: NGGTAAAGCASM; match class: 0 1 P50990 201 2.86e-03 199 3 2 0.667 0.010 GO:0060249 BP 1 anatomical structure homeostasis 1 P40227,P50990 201 2.86e-03 199 3 2 0.667 0.010 GO:0044445 CC 1 cytosolic part 1 P40227,P50990 201 3.52e-03 221 3 2 0.667 0.009 GO:0034504 BP 1 protein localization to nucleus 1 P40227,P50990 201 3.58e-03 223 3 2 0.667 0.009 GO:0032844 BP 1 regulation of homeostatic process 1 P40227,P50990 201 4.01e-03 236 3 2 0.667 0.008 GO:0051052 BP 1 regulation of DNA metabolic process 1 P40227,P50990 201 4.35e-03 906 3 3 1.000 0.003 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q14444,P40227,P50990 201 4.36e-03 246 3 2 0.667 0.008 GO:1903829 BP 1 positive regulation of cellular protein localization 1 P40227,P50990 201 4.71e-03 930 3 3 1.000 0.003 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q14444,P40227,P50990 201 5.07e-03 6 3 1 0.333 0.167 GO:0061003 BP 1 positive regulation of dendritic spine morphogenesis 1 Q14444 201 5.09e-03 266 3 2 0.667 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 P40227,P50990 201 5.40e-03 274 3 2 0.667 0.007 GO:0099081 CC 1 supramolecular polymer 1 P40227,P50990 201 5.40e-03 274 3 2 0.667 0.007 GO:0099512 CC 1 supramolecular fiber 1 P40227,P50990 201 5.75e-03 994 3 3 1.000 0.003 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q14444,P40227,P50990 201 6.17e-03 293 3 2 0.667 0.007 GO:1904951 BP 1 positive regulation of establishment of protein localization 1 P40227,P50990 201 6.21e-03 294 3 2 0.667 0.007 GO:0099080 CC 1 supramolecular complex 1 P40227,P50990 201 6.29e-03 1438 3 3 1.000 0.002 GO:0051128 BP 1 regulation of cellular component organization 1 Q14444,P40227,P50990 201 7.94e-03 1107 3 3 1.000 0.003 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q14444,P40227,P50990 201 8.45e-03 10 3 1 0.333 0.100 GO:0044183 MF 1 protein binding involved in protein folding 1 P40227 201 9.28e-03 360 3 2 0.667 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 P40227,P50990 201 9.40e-03 40 3 1 0.333 0.025 TF:M00615_1 tf 1 Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 1 1 P40227 201 9.40e-03 40 3 1 0.333 0.025 TF:M00615_0 tf 1 Factor: c-Myc:Max; motif: NNNNNNNCACGTGNNNNNNN; match class: 0 1 P40227 201 9.69e-03 368 3 2 0.667 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 P40227,P50990 201 1.04e-02 2781 3 3 1.000 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 Q14444,P40227,P50990 201 1.06e-02 45 3 1 0.333 0.022 TF:M00459_1 tf 1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 1 Q14444 201 1.06e-02 773 3 2 0.667 0.003 TF:M00294_1 tf 1 Factor: HFH8; motif: NNNTGTTTATNTR; match class: 1 1 Q14444,P50990 201 1.10e-02 13 3 1 0.333 0.077 GO:0050775 BP 1 positive regulation of dendrite morphogenesis 1 Q14444 201 1.15e-02 49 3 1 0.333 0.020 TF:M00225_1 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 1 Q14444 201 1.24e-02 53 3 1 0.333 0.019 TF:M05590_0 tf 1 Factor: ZNF772; motif: GTAATGGCTA; match class: 0 1 P50990 201 1.27e-02 15 3 1 0.333 0.067 GO:0060999 BP 1 positive regulation of dendritic spine development 1 Q14444 201 1.31e-02 1307 3 3 1.000 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q14444,P40227,P50990 201 1.32e-02 1310 3 3 1.000 0.002 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 Q14444,P40227,P50990 201 1.41e-02 275 3 2 0.667 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 Q14444,P50990 201 1.42e-02 446 3 2 0.667 0.004 GO:0051276 BP 1 chromosome organization 1 P40227,P50990 201 1.44e-02 17 3 1 0.333 0.059 GO:0061001 BP 1 regulation of dendritic spine morphogenesis 1 Q14444 201 1.47e-02 1360 3 3 1.000 0.002 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q14444,P40227,P50990 201 1.50e-02 1923 3 3 1.000 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q14444,P40227,P50990 201 1.51e-02 1372 3 3 1.000 0.002 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q14444,P40227,P50990 201 1.55e-02 66 3 1 0.333 0.015 TF:M00457_1 tf 1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 1 1 Q14444 201 1.55e-02 467 3 2 0.667 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 P40227,P50990 201 1.59e-02 1396 3 3 1.000 0.002 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 1.63e-02 1976 3 3 1.000 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 Q14444,P40227,P50990 201 1.66e-02 71 3 1 0.333 0.014 TF:M00977_1 tf 1 Factor: EBF; motif: KTCCCYWGRGA; match class: 1 1 Q14444 201 1.67e-02 485 3 2 0.667 0.004 GO:0072594 BP 1 establishment of protein localization to organelle 1 P40227,P50990 201 1.69e-02 72 3 1 0.333 0.014 TF:M07343_1 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 1 1 P50990 201 1.85e-02 510 3 2 0.667 0.004 GO:0060341 BP 1 regulation of cellular localization 1 P40227,P50990 201 1.86e-02 1470 3 3 1.000 0.002 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 1.87e-02 2068 3 3 1.000 0.001 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q14444,P40227,P50990 201 1.89e-02 1477 3 3 1.000 0.002 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 Q14444,P40227,P50990 201 1.92e-02 82 3 1 0.333 0.012 TF:M06024_0 tf 1 Factor: Zipro1; motif: NCMKGACGACT; match class: 0 1 Q14444 201 1.93e-02 2090 3 3 1.000 0.001 GO:0009889 BP 1 regulation of biosynthetic process 1 Q14444,P40227,P50990 201 2.01e-02 86 3 1 0.333 0.012 TF:M00123_1 tf 1 Factor: c-Myc:Max; motif: NANCACGTGNNW; match class: 1 1 P40227 201 2.03e-02 24 3 1 0.333 0.042 GO:0060997 BP 1 dendritic spine morphogenesis 1 Q14444 201 2.06e-02 1521 3 3 1.000 0.002 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.08e-02 1093 3 2 0.667 0.002 TF:M07064_1 tf 1 Factor: STAT1; motif: TTCNRGGAAN; match class: 1 1 Q14444,P50990 201 2.10e-02 544 3 2 0.667 0.004 GO:0032880 BP 1 regulation of protein localization 1 P40227,P50990 201 2.17e-02 19 3 1 0.333 0.053 REAC:5620922 rea 1 BBSome-mediated cargo-targeting to cilium 1 P50990 201 2.22e-02 1559 3 3 1.000 0.002 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.23e-02 2192 3 3 1.000 0.001 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 Q14444,P40227,P50990 201 2.28e-02 27 3 1 0.333 0.037 GO:0060998 BP 1 regulation of dendritic spine development 1 Q14444 201 2.28e-02 27 3 1 0.333 0.037 GO:1900006 BP 1 positive regulation of dendrite development 1 Q14444 201 2.29e-02 1576 3 3 1.000 0.002 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.35e-02 1589 3 3 1.000 0.002 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.36e-02 101 3 1 0.333 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 Q14444 201 2.37e-02 1169 3 2 0.667 0.002 TF:M04302_0 tf 1 Factor: DLX4; motif: NYAATTAN; match class: 0 1 Q14444,P50990 201 2.37e-02 1169 3 2 0.667 0.002 TF:M04301_0 tf 1 Factor: DLX3; motif: NYAATTAN; match class: 0 1 Q14444,P50990 201 2.37e-02 1169 3 2 0.667 0.002 TF:M04304_0 tf 1 Factor: DLX6; motif: NYAATTAN; match class: 0 1 Q14444,P50990 201 2.40e-02 1600 3 3 1.000 0.002 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.42e-02 3682 3 3 1.000 0.001 TF:M00531_0 tf 1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 0 1 Q14444,P40227,P50990 201 2.45e-02 29 3 1 0.333 0.034 GO:0097061 BP 1 dendritic spine organization 1 Q14444 201 2.49e-02 1619 3 3 1.000 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q14444,P40227,P50990 201 2.50e-02 1200 3 2 0.667 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q14444,P40227 201 2.50e-02 1622 3 3 1.000 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.51e-02 368 3 2 0.667 0.005 HPA:022020_13 hpa 1 lung; pneumocytes[Supportive,High] 1 Q14444,P40227 201 2.62e-02 31 3 1 0.333 0.032 GO:0010494 CC 1 cytoplasmic stress granule 1 Q14444 201 2.71e-02 1251 3 2 0.667 0.002 TF:M07343_0 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 0 1 P40227,P50990 201 2.73e-02 1670 3 3 1.000 0.002 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.73e-02 117 3 1 0.333 0.009 TF:M00225_0 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 0 1 Q14444 201 2.81e-02 1276 3 2 0.667 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 P40227,P50990 201 2.90e-02 1704 3 3 1.000 0.002 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 Q14444,P40227,P50990 201 2.92e-02 1707 3 3 1.000 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q14444,P40227,P50990 201 2.95e-02 35 3 1 0.333 0.029 GO:0048814 BP 1 regulation of dendrite morphogenesis 1 Q14444 201 2.95e-02 35 3 1 0.333 0.029 GO:0060996 BP 1 dendritic spine development 1 Q14444 201 3.04e-02 657 3 2 0.667 0.003 GO:0033365 BP 1 protein localization to organelle 1 P40227,P50990 201 3.10e-02 1343 3 2 0.667 0.001 TF:M01260_0 tf 1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 0 1 Q14444,P50990 201 3.11e-02 1345 3 2 0.667 0.001 TF:M07050_0 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 0 1 Q14444,P50990 201 3.16e-02 670 3 2 0.667 0.003 GO:0006259 BP 1 DNA metabolic process 1 P40227,P50990 201 3.17e-02 136 3 1 0.333 0.007 TF:M01002_1 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 1 1 P50990 201 3.22e-02 1765 3 3 1.000 0.002 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q14444,P40227,P50990 201 3.25e-02 1769 3 3 1.000 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 3.25e-02 4062 3 3 1.000 0.001 TF:M00147_0 tf 1 Factor: HSF2; motif: NGAANNWTCK; match class: 0 1 Q14444,P40227,P50990 201 3.31e-02 1780 3 3 1.000 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q14444,P40227,P50990 201 3.35e-02 1787 3 3 1.000 0.002 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 3.39e-02 4118 3 3 1.000 0.001 TF:M00471_0 tf 1 Factor: TBP; motif: TATAAATW; match class: 0 1 Q14444,P40227,P50990 201 3.49e-02 150 3 1 0.333 0.007 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 P40227 201 3.51e-02 707 3 2 0.667 0.003 GO:0033043 BP 1 regulation of organelle organization 1 P40227,P50990 201 3.53e-02 1820 3 3 1.000 0.002 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 3.72e-02 160 3 1 0.333 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q14444 201 3.72e-02 160 3 1 0.333 0.006 TF:M06001_0 tf 1 Factor: ZNF316; motif: RTTGAAAAGM; match class: 0 1 P50990 201 3.75e-02 1857 3 3 1.000 0.002 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 3.79e-02 1863 3 3 1.000 0.002 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 3.80e-02 1492 3 2 0.667 0.001 TF:M01002_0 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 0 1 Q14444,P50990 201 3.87e-02 1507 3 2 0.667 0.001 TF:M00403_0 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 0 1 P40227,P50990 201 3.91e-02 1883 3 3 1.000 0.002 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q14444,P40227,P50990 201 3.93e-02 1885 3 3 1.000 0.002 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q14444,P40227,P50990 201 4.00e-02 172 3 1 0.333 0.006 TF:M00459_0 tf 1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 0 1 Q14444 201 4.00e-02 4354 3 3 1.000 0.001 TF:M04334_1 tf 1 Factor: HMX2; motif: ANCAMTTAANN; match class: 1 1 Q14444,P40227,P50990 201 4.02e-02 173 3 1 0.333 0.006 TF:M01305_0 tf 1 Factor: TEF; motif: YACATTCCWSNG; match class: 0 1 P50990 201 4.05e-02 1904 3 3 1.000 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q14444,P40227,P50990 201 4.07e-02 175 3 1 0.333 0.006 TF:M07228_0 tf 1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 0 1 Q14444 201 4.08e-02 1909 3 3 1.000 0.002 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q14444,P40227,P50990 201 4.14e-02 178 3 1 0.333 0.006 TF:M07100_0 tf 1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 0 1 P50990 201 4.14e-02 769 3 2 0.667 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 P40227,P50990 201 4.18e-02 1924 3 3 1.000 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 4.20e-02 2707 3 3 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q14444,P40227,P50990 201 4.23e-02 1932 3 3 1.000 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q14444,P40227,P50990 201 4.23e-02 182 3 1 0.333 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 Q14444 201 4.29e-02 783 3 2 0.667 0.003 GO:0042592 BP 1 homeostatic process 1 P40227,P50990 201 4.31e-02 484 3 2 0.667 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q14444,P40227 201 4.32e-02 186 3 1 0.333 0.005 TF:M00457_0 tf 1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 0 1 Q14444 201 4.35e-02 1950 3 3 1.000 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 4.38e-02 52 3 1 0.333 0.019 GO:0000932 CC 1 P-body 1 Q14444 201 4.41e-02 1614 3 2 0.667 0.001 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 P40227,P50990 201 4.46e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 Q14444,P40227,P50990 201 4.50e-02 2770 3 3 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q14444,P40227,P50990 201 4.51e-02 1974 3 3 1.000 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q14444,P40227,P50990 201 4.55e-02 54 3 1 0.333 0.019 GO:0048813 BP 1 dendrite morphogenesis 1 Q14444 201 4.56e-02 498 3 2 0.667 0.004 HPA:022010_13 hpa 1 lung; macrophages[Supportive,High] 1 Q14444,P40227 201 4.62e-02 1990 3 3 1.000 0.002 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 4.66e-02 1996 3 3 1.000 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q14444,P40227,P50990 201 4.68e-02 1998 3 3 1.000 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q14444,P40227,P50990 201 4.71e-02 56 3 1 0.333 0.018 GO:0050773 BP 1 regulation of dendrite development 1 Q14444 201 4.73e-02 4605 3 3 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q14444,P40227,P50990 201 4.78e-02 206 3 1 0.333 0.005 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 P40227 201 4.86e-02 2024 3 3 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q14444,P40227,P50990 201 4.88e-02 2026 3 3 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q14444,P40227,P50990 201 4.95e-02 4673 3 3 1.000 0.001 TF:M04300_1 tf 1 Factor: DLX2; motif: NYAATTAN; match class: 1 1 Q14444,P40227,P50990 201 4.97e-02 2039 3 3 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q14444,P40227,P50990 201 5.00e-02 44 3 1 0.333 0.023 REAC:5620920 rea 1 Cargo trafficking to the periciliary membrane 1 P50990 201 5.00e-02 2869 3 3 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q14444,P40227,P50990 201 5.00e-02 445 3 2 0.667 0.004 MI:hsa-miR-509-3-5p mi 1 MI:hsa-miR-509-3-5p 1 P40227,P50990 202 3.27e-03 3 2 1 0.500 0.333 GO:0020016 CC 1 ciliary pocket 1 Q9H4M9 202 3.27e-03 3 2 1 0.500 0.333 GO:0020018 CC 1 ciliary pocket membrane 1 Q9H4M9 202 4.36e-03 4 2 1 0.500 0.250 GO:0010886 BP 1 positive regulation of cholesterol storage 1 Q9H4M9 202 4.36e-03 4 2 1 0.500 0.250 GO:2001137 BP 1 positive regulation of endocytic recycling 1 Q9H4M9 202 5.44e-03 5 2 1 0.500 0.200 GO:1901741 BP 1 positive regulation of myoblast fusion 1 Q9H4M9 202 6.53e-03 6 2 1 0.500 0.167 GO:1901739 BP 1 regulation of myoblast fusion 1 Q9H4M9 202 6.53e-03 6 2 1 0.500 0.167 GO:2001135 BP 1 regulation of endocytic recycling 1 Q9H4M9 202 7.62e-03 7 2 1 0.500 0.143 GO:0060143 BP 1 positive regulation of syncytium formation by plasma membrane fusion 1 Q9H4M9 202 8.71e-03 8 2 1 0.500 0.125 GO:0010885 BP 1 regulation of cholesterol storage 1 Q9H4M9 202 8.71e-03 8 2 1 0.500 0.125 GO:0060142 BP 1 regulation of syncytium formation by plasma membrane fusion 1 Q9H4M9 202 9.80e-03 9 2 1 0.500 0.111 GO:0010831 BP 1 positive regulation of myotube differentiation 1 Q9H4M9 202 9.80e-03 9 2 1 0.500 0.111 GO:0031094 CC 1 platelet dense tubular network 1 Q9H4M9 202 9.80e-03 9 2 1 0.500 0.111 GO:0031095 CC 1 platelet dense tubular network membrane 1 Q9H4M9 202 1.09e-02 10 2 1 0.500 0.100 GO:0010878 BP 1 cholesterol storage 1 Q9H4M9 202 1.09e-02 10 2 1 0.500 0.100 GO:0034383 BP 1 low-density lipoprotein particle clearance 1 Q9H4M9 202 1.20e-02 11 2 1 0.500 0.091 GO:1990090 BP 1 cellular response to nerve growth factor stimulus 1 Q9H4M9 202 1.20e-02 11 2 1 0.500 0.091 GO:0007520 BP 1 myoblast fusion 1 Q9H4M9 202 1.20e-02 11 2 1 0.500 0.091 GO:1990089 BP 1 response to nerve growth factor 1 Q9H4M9 202 1.20e-02 11 2 1 0.500 0.091 GO:0010884 BP 1 positive regulation of lipid storage 1 Q9H4M9 202 1.52e-02 14 2 1 0.500 0.071 GO:0006949 BP 1 syncytium formation 1 Q9H4M9 202 1.52e-02 14 2 1 0.500 0.071 GO:0000768 BP 1 syncytium formation by plasma membrane fusion 1 Q9H4M9 202 1.63e-02 15 2 1 0.500 0.067 GO:0034381 BP 1 plasma lipoprotein particle clearance 1 Q9H4M9 202 1.74e-02 16 2 1 0.500 0.062 GO:0051155 BP 1 positive regulation of striated muscle cell differentiation 1 Q9H4M9 202 2.18e-02 20 2 1 0.500 0.050 GO:0055038 CC 1 recycling endosome membrane 1 Q9H4M9 202 2.29e-02 21 2 1 0.500 0.048 GO:0061512 BP 1 protein localization to cilium 1 Q9H4M9 202 2.39e-02 22 2 1 0.500 0.045 GO:0010830 BP 1 regulation of myotube differentiation 1 Q9H4M9 202 2.83e-02 26 2 1 0.500 0.038 GO:0032456 BP 1 endocytic recycling 1 Q9H4M9 202 2.94e-02 27 2 1 0.500 0.037 GO:0010883 BP 1 regulation of lipid storage 1 Q9H4M9 202 3.15e-02 29 2 1 0.500 0.034 GO:0060170 CC 1 ciliary membrane 1 Q9H4M9 202 3.15e-02 29 2 1 0.500 0.034 GO:0097006 BP 1 regulation of plasma lipoprotein particle levels 1 Q9H4M9 202 3.70e-02 34 2 1 0.500 0.029 GO:0051153 BP 1 regulation of striated muscle cell differentiation 1 Q9H4M9 202 3.81e-02 35 2 1 0.500 0.029 GO:0055092 BP 1 sterol homeostasis 1 Q9H4M9 202 3.81e-02 35 2 1 0.500 0.029 GO:0042632 BP 1 cholesterol homeostasis 1 Q9H4M9 202 4.02e-02 37 2 1 0.500 0.027 GO:0019915 BP 1 lipid storage 1 Q9H4M9 202 4.02e-02 37 2 1 0.500 0.027 GO:0051149 BP 1 positive regulation of muscle cell differentiation 1 Q9H4M9 202 4.02e-02 37 2 1 0.500 0.027 GO:0014902 BP 1 myotube differentiation 1 Q9H4M9 202 4.89e-02 45 2 1 0.500 0.022 GO:0031901 CC 1 early endosome membrane 1 Q9H4M9 202 5.00e-02 5 2 1 0.500 0.200 TF:M04573_0 tf 1 Factor: RARB; motif: AAAGGTCAARAGGTCA; match class: 0 1 Q5BKX5 202 5.00e-02 46 2 1 0.500 0.022 GO:0005811 CC 1 lipid particle 1 Q9H4M9 202 5.00e-02 117 2 1 0.500 0.009 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 Q9H4M9 202 5.00e-02 478 2 2 1.000 0.004 MI:hsa-miR-125b mi 1 MI:hsa-miR-125b 1 Q9H4M9,Q5BKX5 203 1.54e-06 2 8 2 0.250 1.000 GO:0003056 BP 1 regulation of vascular smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 1.54e-06 2 8 2 0.250 1.000 GO:1904694 BP 1 negative regulation of vascular smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 4.63e-06 3 8 2 0.250 0.667 GO:0045986 BP 1 negative regulation of smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 5.79e-06 24 8 3 0.375 0.125 REAC:8849471 rea 1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 Q96JJ3,Q14185,Q92556 203 9.26e-06 4 8 2 0.250 0.500 GO:0045906 BP 1 negative regulation of vasoconstriction 1 Q8N1I0,Q9H7D0 203 9.26e-06 4 8 2 0.250 0.500 GO:1904754 BP 1 positive regulation of vascular associated smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 1.41e-05 117 8 4 0.500 0.034 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 Q8IZD9,Q8N1I0,Q9H7D0,Q14185 203 1.54e-05 5 8 2 0.250 0.400 GO:0014829 BP 1 vascular smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 1.54e-05 5 8 2 0.250 0.400 GO:1904738 BP 1 vascular associated smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 1.54e-05 5 8 2 0.250 0.400 GO:1904752 BP 1 regulation of vascular associated smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 1.54e-05 5 8 2 0.250 0.400 GO:0032045 CC 1 guanyl-nucleotide exchange factor complex 1 Q14185,Q92556 203 3.24e-05 7 8 2 0.250 0.286 GO:0014911 BP 1 positive regulation of smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 3.24e-05 7 8 2 0.250 0.286 GO:0045932 BP 1 negative regulation of muscle contraction 1 Q8N1I0,Q9H7D0 203 3.94e-05 68 8 3 0.375 0.044 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 Q96JJ3,Q14185,Q92556 203 3.94e-05 68 8 3 0.375 0.044 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 Q96JJ3,Q14185,Q92556 203 3.94e-05 68 8 3 0.375 0.044 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 Q96JJ3,Q14185,Q92556 203 4.30e-05 70 8 3 0.375 0.043 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 Q96JJ3,Q14185,Q92556 203 4.49e-05 71 8 3 0.375 0.042 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 Q96JJ3,Q14185,Q92556 203 5.09e-05 2 8 2 0.250 1.000 CORUM:5337 cor 1 ELMO1-DOCK1 complex 1 Q14185,Q92556 203 7.80e-05 56 8 3 0.375 0.054 REAC:8848021 rea 1 Signaling by PTK6 1 Q96JJ3,Q14185,Q92556 203 8.47e-05 11 8 2 0.250 0.182 GO:1903523 BP 1 negative regulation of blood circulation 1 Q8N1I0,Q9H7D0 203 9.13e-05 59 8 3 0.375 0.051 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 Q96JJ3,Q14185,Q92556 203 1.52e-04 3 8 2 0.250 0.667 CORUM:5343 cor 1 ELMO1-DOCK1-CRKII complex 1 Q14185,Q92556 203 1.52e-04 3 8 2 0.250 0.667 CORUM:5342 cor 1 ELMO1-DOCK1-RAC1 complex 1 Q14185,Q92556 203 1.84e-04 16 8 2 0.250 0.125 GO:0006940 BP 1 regulation of smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 2.09e-04 17 8 2 0.250 0.118 GO:0006911 BP 1 phagocytosis, engulfment 1 Q14185,Q92556 203 2.37e-04 81 8 3 0.375 0.037 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 Q96JJ3,Q14185,Q92556 203 2.62e-04 19 8 2 0.250 0.105 GO:0019229 BP 1 regulation of vasoconstriction 1 Q8N1I0,Q9H7D0 203 2.62e-04 19 8 2 0.250 0.105 GO:0014910 BP 1 regulation of smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 3.59e-04 142 8 3 0.375 0.021 GO:0006909 BP 1 phagocytosis 1 Q96JJ3,Q14185,Q92556 203 3.88e-04 23 8 2 0.250 0.087 GO:1900026 BP 1 positive regulation of substrate adhesion-dependent cell spreading 1 Q9H7D0,Q14185 203 4.23e-04 24 8 2 0.250 0.083 GO:0014909 BP 1 smooth muscle cell migration 1 Q8N1I0,Q9H7D0 203 4.23e-04 24 8 2 0.250 0.083 GO:0042310 BP 1 vasoconstriction 1 Q8N1I0,Q9H7D0 203 4.60e-04 25 8 2 0.250 0.080 GO:0099024 BP 1 plasma membrane invagination 1 Q14185,Q92556 203 5.37e-04 27 8 2 0.250 0.074 GO:0014812 BP 1 muscle cell migration 1 Q8N1I0,Q9H7D0 203 5.60e-04 165 8 3 0.375 0.018 GO:0038093 BP 1 Fc receptor signaling pathway 1 Q96JJ3,Q14185,Q92556 203 7.58e-04 32 8 2 0.250 0.062 GO:0010324 BP 1 membrane invagination 1 Q14185,Q92556 203 7.58e-04 32 8 2 0.250 0.062 GO:0006939 BP 1 smooth muscle contraction 1 Q8N1I0,Q9H7D0 203 8.06e-04 33 8 2 0.250 0.061 GO:1900024 BP 1 regulation of substrate adhesion-dependent cell spreading 1 Q9H7D0,Q14185 203 8.50e-04 190 8 3 0.375 0.016 GO:0005085 MF 1 guanyl-nucleotide exchange factor activity 1 Q9H7D0,Q14185,Q92556 203 8.60e-04 1016 8 5 0.625 0.005 GO:0006928 BP 1 movement of cell or subcellular component 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185,Q92556 203 9.61e-04 36 8 2 0.250 0.056 GO:1990782 MF 1 protein tyrosine kinase binding 1 Q96JJ3,Q8N1I0 203 9.61e-04 36 8 2 0.250 0.056 GO:0030971 MF 1 receptor tyrosine kinase binding 1 Q96JJ3,Q8N1I0 203 1.02e-03 37 8 2 0.250 0.054 GO:0035296 BP 1 regulation of tube diameter 1 Q8N1I0,Q9H7D0 203 1.02e-03 37 8 2 0.250 0.054 GO:0097746 BP 1 regulation of blood vessel diameter 1 Q8N1I0,Q9H7D0 203 1.13e-03 39 8 2 0.250 0.051 GO:0035150 BP 1 regulation of tube size 1 Q8N1I0,Q9H7D0 203 1.13e-03 39 8 2 0.250 0.051 GO:0050880 BP 1 regulation of blood vessel size 1 Q8N1I0,Q9H7D0 203 1.24e-03 216 8 3 0.375 0.014 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 Q96JJ3,Q14185,Q92556 203 1.33e-03 221 8 3 0.375 0.014 GO:0030335 BP 1 positive regulation of cell migration 1 Q8N1I0,Q9H7D0,Q14185 203 1.37e-03 43 8 2 0.250 0.047 GO:0010811 BP 1 positive regulation of cell-substrate adhesion 1 Q9H7D0,Q14185 203 1.44e-03 227 8 3 0.375 0.013 GO:2000147 BP 1 positive regulation of cell motility 1 Q8N1I0,Q9H7D0,Q14185 203 1.57e-03 234 8 3 0.375 0.013 GO:0051272 BP 1 positive regulation of cellular component movement 1 Q8N1I0,Q9H7D0,Q14185 203 1.59e-03 235 8 3 0.375 0.013 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 Q96JJ3,Q14185,Q92556 203 1.82e-03 246 8 3 0.375 0.012 GO:0040017 BP 1 positive regulation of locomotion 1 Q8N1I0,Q9H7D0,Q14185 203 1.86e-03 50 8 2 0.250 0.040 GO:0003018 BP 1 vascular process in circulatory system 1 Q8N1I0,Q9H7D0 203 2.01e-03 640 8 4 0.500 0.006 GO:0016477 BP 1 cell migration 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185 203 2.59e-03 59 8 2 0.250 0.034 GO:0034446 BP 1 substrate adhesion-dependent cell spreading 1 Q9H7D0,Q14185 203 2.62e-03 444 8 4 0.500 0.009 REAC:109582 rea 1 Hemostasis 1 Q8IZD9,Q8N1I0,Q9H7D0,Q14185 203 2.68e-03 60 8 2 0.250 0.033 GO:0010770 BP 1 positive regulation of cell morphogenesis involved in differentiation 1 Q9H7D0,Q14185 203 3.01e-03 711 8 4 0.500 0.006 GO:0048870 BP 1 cell motility 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185 203 3.01e-03 711 8 4 0.500 0.006 GO:0051674 BP 1 localization of cell 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185 203 3.34e-03 67 8 2 0.250 0.030 GO:0010634 BP 1 positive regulation of epithelial cell migration 1 Q9H7D0,Q14185 203 3.34e-03 303 8 3 0.375 0.010 GO:0002757 BP 1 immune response-activating signal transduction 1 Q96JJ3,Q14185,Q92556 203 3.44e-03 68 8 2 0.250 0.029 GO:0006937 BP 1 regulation of muscle contraction 1 Q8N1I0,Q9H7D0 203 3.81e-03 317 8 3 0.375 0.009 GO:0002252 BP 1 immune effector process 1 Q96JJ3,Q14185,Q92556 203 3.99e-03 322 8 3 0.375 0.009 GO:0002764 BP 1 immune response-regulating signaling pathway 1 Q96JJ3,Q14185,Q92556 203 4.55e-03 337 8 3 0.375 0.009 GO:0002253 BP 1 activation of immune response 1 Q96JJ3,Q14185,Q92556 203 5.02e-03 814 8 4 0.500 0.005 GO:0040011 BP 1 locomotion 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185 203 5.09e-03 2 8 1 0.125 0.500 GO:0031685 MF 1 adenosine receptor binding 1 Q13107 203 5.25e-03 354 8 3 0.375 0.008 GO:0006897 BP 1 endocytosis 1 Q96JJ3,Q14185,Q92556 203 5.36e-03 85 8 2 0.250 0.024 GO:0090257 BP 1 regulation of muscle system process 1 Q8N1I0,Q9H7D0 203 5.36e-03 828 8 4 0.500 0.005 GO:0098772 MF 1 molecular function regulator 1 Q8N1I0,Q9H7D0,Q14185,Q92556 203 5.96e-03 370 8 3 0.375 0.008 GO:0030334 BP 1 regulation of cell migration 1 Q8N1I0,Q9H7D0,Q14185 203 6.00e-03 90 8 2 0.250 0.022 GO:0010810 BP 1 regulation of cell-substrate adhesion 1 Q9H7D0,Q14185 203 6.79e-03 387 8 3 0.375 0.008 GO:0050778 BP 1 positive regulation of immune response 1 Q96JJ3,Q14185,Q92556 203 7.53e-03 101 8 2 0.250 0.020 GO:0060326 BP 1 cell chemotaxis 1 Q96JJ3,Q8N1I0 203 7.68e-03 404 8 3 0.375 0.007 GO:2000145 BP 1 regulation of cell motility 1 Q8N1I0,Q9H7D0,Q14185 203 8.33e-03 272 8 3 0.375 0.011 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q96JJ3,Q14185,Q92556 203 8.60e-03 108 8 2 0.250 0.019 GO:0010632 BP 1 regulation of epithelial cell migration 1 Q9H7D0,Q14185 203 8.87e-03 278 8 3 0.375 0.011 REAC:194138 rea 1 Signaling by VEGF 1 Q96JJ3,Q14185,Q92556 203 9.31e-03 432 8 3 0.375 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q96JJ3,Q14185,Q92556 203 9.68e-03 438 8 3 0.375 0.007 GO:0051270 BP 1 regulation of cellular component movement 1 Q8N1I0,Q9H7D0,Q14185 203 9.94e-03 442 8 3 0.375 0.007 GO:0040012 BP 1 regulation of locomotion 1 Q8N1I0,Q9H7D0,Q14185 203 1.40e-02 499 8 3 0.375 0.006 GO:0002684 BP 1 positive regulation of immune system process 1 Q96JJ3,Q14185,Q92556 203 1.41e-02 139 8 2 0.250 0.014 GO:0010769 BP 1 regulation of cell morphogenesis involved in differentiation 1 Q9H7D0,Q14185 203 1.42e-02 501 8 3 0.375 0.006 GO:0050776 BP 1 regulation of immune response 1 Q96JJ3,Q14185,Q92556 203 1.45e-02 141 8 2 0.250 0.014 GO:1903522 BP 1 regulation of blood circulation 1 Q8N1I0,Q9H7D0 203 1.51e-02 144 8 2 0.250 0.014 GO:0010631 BP 1 epithelial cell migration 1 Q9H7D0,Q14185 203 1.53e-02 145 8 2 0.250 0.014 GO:0090132 BP 1 epithelium migration 1 Q9H7D0,Q14185 203 1.60e-02 148 8 2 0.250 0.014 GO:0090130 BP 1 tissue migration 1 Q9H7D0,Q14185 203 1.95e-02 164 8 2 0.250 0.012 GO:0006936 BP 1 muscle contraction 1 Q8N1I0,Q9H7D0 203 2.02e-02 167 8 2 0.250 0.012 GO:0005096 MF 1 GTPase activator activity 1 Q8N1I0,Q14185 203 2.03e-02 3033 8 6 0.750 0.002 GO:0048518 BP 1 positive regulation of biological process 1 Q96JJ3,Q8N1I0,Q9H7D0,Q14185,Q92556,Q8TD17 203 2.04e-02 168 8 2 0.250 0.012 GO:0045785 BP 1 positive regulation of cell adhesion 1 Q9H7D0,Q14185 203 2.12e-02 171 8 2 0.250 0.012 GO:0031589 BP 1 cell-substrate adhesion 1 Q9H7D0,Q14185 203 2.21e-02 175 8 2 0.250 0.011 GO:0010720 BP 1 positive regulation of cell development 1 Q9H7D0,Q14185 203 2.29e-02 593 8 3 0.375 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q96JJ3,Q14185,Q92556 203 2.39e-02 349 8 2 0.250 0.006 MI:hsa-miR-197 mi 1 MI:hsa-miR-197 1 Q96JJ3,Q13107 203 2.44e-02 184 8 2 0.250 0.011 GO:0001667 BP 1 ameboidal-type cell migration 1 Q9H7D0,Q14185 203 2.60e-02 190 8 2 0.250 0.011 GO:0003012 BP 1 muscle system process 1 Q8N1I0,Q9H7D0 203 2.73e-02 195 8 2 0.250 0.010 GO:0030695 MF 1 GTPase regulator activity 1 Q8N1I0,Q14185 203 2.87e-02 8 8 1 0.125 0.125 REAC:164944 rea 1 Nef and signal transduction 1 Q92556 203 3.04e-02 12 8 1 0.125 0.083 GO:0032420 CC 1 stereocilium 1 Q8N1I0 203 3.04e-02 12 8 1 0.125 0.083 GO:0000244 BP 1 spliceosomal tri-snRNP complex assembly 1 Q13107 203 3.04e-02 12 8 1 0.125 0.083 GO:0032421 CC 1 stereocilium bundle 1 Q8N1I0 203 3.07e-02 62 8 3 0.375 0.048 KEGG:05131 keg 1 Shigellosis 1 Q96JJ3,Q14185,Q92556 203 3.18e-02 211 8 2 0.250 0.009 GO:0008015 BP 1 blood circulation 1 Q8N1I0,Q9H7D0 203 3.19e-02 407 8 2 0.250 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 Q9H7D0,Q92556 203 3.21e-02 212 8 2 0.250 0.009 GO:0003013 BP 1 circulatory system process 1 Q8N1I0,Q9H7D0 203 3.27e-02 214 8 2 0.250 0.009 GO:0044057 BP 1 regulation of system process 1 Q8N1I0,Q9H7D0 203 3.30e-02 215 8 2 0.250 0.009 GO:0090066 BP 1 regulation of anatomical structure size 1 Q8N1I0,Q9H7D0 203 3.34e-02 2 8 1 0.125 0.500 CORUM:5341 cor 1 ELMO1-DOCK2 complex 1 Q92556 203 3.41e-02 422 8 2 0.250 0.005 MI:hsa-miR-566 mi 1 MI:hsa-miR-566 1 Q8IZD9,Q13107 203 3.49e-02 690 8 3 0.375 0.004 GO:0002682 BP 1 regulation of immune system process 1 Q96JJ3,Q14185,Q92556 203 3.51e-02 222 8 2 0.250 0.009 GO:0060589 MF 1 nucleoside-triphosphatase regulator activity 1 Q8N1I0,Q14185 203 3.58e-02 10 8 1 0.125 0.100 REAC:5357786 rea 1 TNFR1-induced proapoptotic signaling 1 Q13107 203 3.76e-02 445 8 2 0.250 0.004 MI:hsa-miR-509-3-5p mi 1 MI:hsa-miR-509-3-5p 1 Q8IZD9,Q92556 203 3.77e-02 3401 8 6 0.750 0.002 GO:0051179 BP 1 localization 1 Q96JJ3,Q13107,Q8N1I0,Q9H7D0,Q14185,Q92556 203 4.09e-02 731 8 3 0.375 0.004 GO:0005102 MF 1 receptor binding 1 Q96JJ3,Q13107,Q8N1I0 203 4.22e-02 739 8 3 0.375 0.004 GO:0006955 BP 1 immune response 1 Q96JJ3,Q14185,Q92556 203 4.24e-02 475 8 2 0.250 0.004 MI:hsa-miR-671-5p mi 1 MI:hsa-miR-671-5p 1 Q96JJ3,Q92556 203 4.27e-02 246 8 2 0.250 0.008 GO:0042330 BP 1 taxis 1 Q96JJ3,Q8N1I0 203 4.27e-02 246 8 2 0.250 0.008 GO:0006935 BP 1 chemotaxis 1 Q96JJ3,Q8N1I0 203 4.42e-02 486 8 2 0.250 0.004 MI:hsa-miR-362-3p mi 1 MI:hsa-miR-362-3p 1 Q96JJ3,Q14185 203 4.48e-02 252 8 2 0.250 0.008 GO:0022604 BP 1 regulation of cell morphogenesis 1 Q9H7D0,Q14185 203 4.61e-02 497 8 2 0.250 0.004 MI:hsa-miR-220b mi 1 MI:hsa-miR-220b 1 Q13107,Q14185 203 4.81e-02 19 8 1 0.125 0.053 GO:0016601 BP 1 Rac protein signal transduction 1 Q92556 203 5.00e-02 267 8 2 0.250 0.007 GO:0007264 BP 1 small GTPase mediated signal transduction 1 Q14185,Q92556 203 5.00e-02 3 8 1 0.125 0.333 CORUM:2962 cor 1 CRK-BCAR1-DOCK1 complex 1 Q14185 203 5.00e-02 73 8 3 0.375 0.041 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 Q96JJ3,Q14185,Q92556 203 5.00e-02 14 8 1 0.125 0.071 REAC:418885 rea 1 DCC mediated attractive signaling 1 Q14185 203 5.00e-02 277 8 3 0.375 0.011 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q96JJ3,Q8N1I0,Q8TD17 204 5.18e-17 11 7 6 0.857 0.545 REAC:2468052 rea 1 Establishment of Sister Chromatid Cohesion 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 6.58e-15 10 7 5 0.714 0.500 GO:0008278 CC 1 cohesin complex 1 Q7Z5K2,Q8NDV3,Q9UQE7,Q96FF9,O60216 204 1.02e-13 10 7 5 0.714 0.500 REAC:2470946 rea 1 Cohesin Loading onto Chromatin 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 8.09e-13 14 7 5 0.714 0.357 REAC:68884 rea 1 Mitotic Telophase/Cytokinesis 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 1.33e-11 116 7 6 0.857 0.052 GO:0007062 BP 1 sister chromatid cohesion 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.73e-11 121 7 6 0.857 0.050 GO:0000775 CC 1 chromosome, centromeric region 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.24e-10 99 7 6 0.857 0.061 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.00e-10 107 7 6 0.857 0.056 REAC:68877 rea 1 Mitotic Prometaphase 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.26e-10 196 7 6 0.857 0.031 GO:0000819 BP 1 sister chromatid segregation 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.86e-10 43 7 5 0.714 0.116 REAC:1221632 rea 1 Meiotic synapsis 1 Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 5.45e-10 126 7 6 0.857 0.048 REAC:69242 rea 1 S Phase 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 7.72e-10 226 7 6 0.857 0.027 GO:0098813 BP 1 nuclear chromosome segregation 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 8.58e-10 230 7 6 0.857 0.026 GO:0098687 CC 1 chromosomal region 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.38e-09 565 7 7 1.000 0.012 GO:0044427 CC 1 chromosomal part 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.75e-09 98 7 5 0.714 0.051 GO:0000793 CC 1 condensed chromosome 1 Q7Z5K2,Q8NDV3,Q9UQE7,Q96FF9,O60216 204 1.93e-09 263 7 6 0.857 0.023 GO:0007059 BP 1 chromosome segregation 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.34e-09 609 7 7 1.000 0.011 GO:0005694 CC 1 chromosome 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.42e-09 161 7 6 0.857 0.037 REAC:2467813 rea 1 Separation of Sister Chromatids 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.62e-09 172 7 6 0.857 0.035 REAC:68882 rea 1 Mitotic Anaphase 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.75e-09 173 7 6 0.857 0.035 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.16e-09 68 7 5 0.714 0.074 REAC:1500620 rea 1 Meiosis 1 Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 5.79e-09 6 7 3 0.429 0.500 GO:0030893 CC 1 meiotic cohesin complex 1 Q8NDV3,Q9UQE7,O60216 204 3.74e-08 253 7 6 0.857 0.024 REAC:68886 rea 1 M Phase 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.35e-08 547 7 7 1.000 0.013 REAC:1640170 rea 1 Cell Cycle 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.63e-08 446 7 6 0.857 0.013 GO:0051276 BP 1 chromosome organization 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 6.36e-08 12 7 3 0.429 0.250 GO:0071168 BP 1 protein localization to chromatin 1 Q7Z5K2,Q96FF9,O60216 204 2.35e-07 18 7 3 0.429 0.167 GO:0007063 BP 1 regulation of sister chromatid cohesion 1 Q7Z5K2,Q96FF9,O60216 204 3.83e-07 21 7 3 0.429 0.143 GO:0007064 BP 1 mitotic sister chromatid cohesion 1 Q7Z5K2,Q96FF9,O60216 204 4.43e-07 294 7 5 0.714 0.017 GO:0000785 CC 1 chromatin 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9 204 4.45e-07 16 7 4 0.571 0.250 CORUM:282 cor 1 SNF2h-cohesin-NuRD complex 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:166 cor 1 Cohesin-SA2 complex 1 Q8N3U4,Q9UQE7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:64 cor 1 Mitotic 14S cohesin 2 complex 1 Q8N3U4,Q9UQE7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:63 cor 1 Mitotic 14S cohesin 1 complex 1 Q9UQE7,Q8WVM7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:163 cor 1 Cohesin-SA2 complex 1 Q8N3U4,Q9UQE7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:165 cor 1 Cohesin-SA1 complex 1 Q9UQE7,Q8WVM7,O60216 204 5.68e-07 4 7 3 0.429 0.750 CORUM:164 cor 1 Cohesin-SA1 complex 1 Q9UQE7,Q8WVM7,O60216 204 8.05e-07 120 7 4 0.571 0.033 GO:0016925 BP 1 protein sumoylation 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 8.23e-07 117 7 5 0.714 0.043 KEGG:04110 keg 1 Cell cycle 1 Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 8.42e-07 27 7 3 0.429 0.111 GO:0008156 BP 1 negative regulation of DNA replication 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 1.15e-06 448 7 6 0.857 0.013 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.16e-06 75 7 4 0.571 0.053 REAC:3108214 rea 1 SUMOylation of DNA damage response and repair proteins 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 2.00e-06 3 7 2 0.286 0.667 GO:0034085 BP 1 establishment of sister chromatid cohesion 1 Q7Z5K2,Q96FF9 204 2.00e-06 3 7 2 0.286 0.667 GO:0000798 CC 1 nuclear cohesin complex 1 Q7Z5K2,O60216 204 2.00e-06 3 7 2 0.286 0.667 GO:1905634 BP 1 regulation of protein localization to chromatin 1 Q7Z5K2,Q96FF9 204 2.00e-06 3 7 2 0.286 0.667 GO:0071922 BP 1 regulation of cohesin loading 1 Q7Z5K2,Q96FF9 204 2.00e-06 3 7 2 0.286 0.667 GO:0071921 BP 1 cohesin loading 1 Q7Z5K2,Q96FF9 204 2.10e-06 402 7 5 0.714 0.012 GO:0010564 BP 1 regulation of cell cycle process 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q96FF9,O60216 204 2.83e-06 6 7 3 0.429 0.500 CORUM:5432 cor 1 Sororin-cohesin complex 1 Q9UQE7,Q96FF9,O60216 204 2.83e-06 6 7 3 0.429 0.500 CORUM:1856 cor 1 CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex 1 Q9UQE7,Q96FF9,O60216 204 3.56e-06 99 7 4 0.571 0.040 REAC:3108232 rea 1 SUMO E3 ligases SUMOylate target proteins 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 4.29e-06 952 7 6 0.857 0.006 GO:0022402 BP 1 cell cycle process 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.51e-06 105 7 4 0.571 0.038 REAC:2990846 rea 1 SUMOylation 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 6.67e-06 5 7 2 0.286 0.400 GO:0032876 BP 1 negative regulation of DNA endoreduplication 1 Q8N3U4,Q9UQE7 204 6.70e-06 53 7 3 0.429 0.057 GO:0033045 BP 1 regulation of sister chromatid segregation 1 Q7Z5K2,Q96FF9,O60216 204 7.50e-06 55 7 3 0.429 0.055 GO:0034502 BP 1 protein localization to chromosome 1 Q7Z5K2,Q96FF9,O60216 204 8.58e-06 1960 7 7 1.000 0.004 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 8.58e-06 1960 7 7 1.000 0.004 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.17e-05 1128 7 6 0.857 0.005 GO:0007049 BP 1 cell cycle 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.21e-05 236 7 4 0.571 0.017 GO:0007067 BP 1 mitotic nuclear division 1 Q7Z5K2,Q9UQE7,Q96FF9,O60216 204 1.40e-05 7 7 2 0.286 0.286 GO:0032875 BP 1 regulation of DNA endoreduplication 1 Q8N3U4,Q9UQE7 204 1.44e-05 1168 7 6 0.857 0.005 GO:1902589 BP 1 single-organism organelle organization 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.49e-05 69 7 3 0.429 0.043 GO:0051983 BP 1 regulation of chromosome segregation 1 Q7Z5K2,Q96FF9,O60216 204 1.87e-05 8 7 2 0.286 0.250 GO:0042023 BP 1 DNA endoreduplication 1 Q8N3U4,Q9UQE7 204 2.00e-05 76 7 3 0.429 0.039 GO:0006275 BP 1 regulation of DNA replication 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.33e-05 80 7 3 0.429 0.037 GO:0051053 BP 1 negative regulation of DNA metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.63e-05 670 7 5 0.714 0.007 GO:0006259 BP 1 DNA metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q96FF9,O60216 204 2.80e-05 679 7 5 0.714 0.007 GO:0051726 BP 1 regulation of cell cycle 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q96FF9,O60216 204 2.96e-05 296 7 4 0.571 0.014 GO:0018205 BP 1 peptidyl-lysine modification 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 3.51e-05 309 7 4 0.571 0.013 GO:0000280 BP 1 nuclear division 1 Q7Z5K2,Q9UQE7,Q96FF9,O60216 204 3.67e-05 93 7 3 0.429 0.032 GO:0007126 BP 1 meiotic nuclear division 1 Q7Z5K2,Q9UQE7,O60216 204 4.30e-05 98 7 3 0.429 0.031 GO:1903046 BP 1 meiotic cell cycle process 1 Q7Z5K2,Q9UQE7,O60216 204 4.30e-05 98 7 3 0.429 0.031 GO:0051321 BP 1 meiotic cell cycle 1 Q7Z5K2,Q9UQE7,O60216 204 5.12e-05 2529 7 7 1.000 0.003 GO:0005654 CC 1 nucleoplasm 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.12e-05 340 7 4 0.571 0.012 GO:0048285 BP 1 organelle fission 1 Q7Z5K2,Q9UQE7,Q96FF9,O60216 204 6.99e-05 15 7 2 0.286 0.133 GO:2000104 BP 1 negative regulation of DNA-dependent DNA replication 1 Q8N3U4,Q9UQE7 204 7.31e-05 117 7 3 0.429 0.026 GO:0033044 BP 1 regulation of chromosome organization 1 Q7Z5K2,Q96FF9,O60216 204 7.69e-05 119 7 3 0.429 0.025 GO:0000070 BP 1 mitotic sister chromatid segregation 1 Q7Z5K2,Q96FF9,O60216 204 1.02e-04 18 7 2 0.286 0.111 GO:0030261 BP 1 chromosome condensation 1 Q7Z5K2,Q96FF9 204 1.26e-04 20 7 2 0.286 0.100 GO:0043388 BP 1 positive regulation of DNA binding 1 Q7Z5K2,Q96FF9 204 1.44e-04 2931 7 7 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.00e-04 164 7 3 0.429 0.018 GO:0010948 BP 1 negative regulation of cell cycle process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.48e-04 3168 7 7 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.69e-04 29 7 2 0.286 0.069 GO:0044786 BP 1 cell cycle DNA replication 1 Q8N3U4,Q9UQE7 204 3.50e-04 33 7 2 0.286 0.061 GO:0045132 BP 1 meiotic chromosome segregation 1 Q7Z5K2,O60216 204 3.52e-04 3 7 2 0.286 0.667 OMIM:122470 omi 1 Cornelia de Lange Syndrome 1 Q9UQE7,O60216 204 3.94e-04 35 7 2 0.286 0.057 GO:0090329 BP 1 regulation of DNA-dependent DNA replication 1 Q8N3U4,Q9UQE7 204 3.96e-04 573 7 4 0.571 0.007 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 4.20e-04 3415 7 7 1.000 0.002 GO:0032991 CC 1 macromolecular complex 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.60e-04 217 7 3 0.429 0.014 GO:0006260 BP 1 DNA replication 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 4.69e-04 4 7 2 0.286 0.500 HP:0005565 hp 1 Reduced renal corticomedullary differentiation 1 Q9UQE7,O60216 204 5.63e-04 3561 7 7 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.63e-04 3561 7 7 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.63e-04 3561 7 7 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.89e-04 236 7 3 0.429 0.013 GO:0051052 BP 1 regulation of DNA metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 6.73e-04 657 7 4 0.571 0.006 GO:1903047 BP 1 mitotic cell cycle process 1 Q7Z5K2,Q9UQE7,Q96FF9,O60216 204 6.93e-04 662 7 4 0.571 0.006 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 6.97e-04 2262 7 6 0.857 0.003 GO:0006996 BP 1 organelle organization 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 7.44e-04 48 7 2 0.286 0.042 GO:0051101 BP 1 regulation of DNA binding 1 Q7Z5K2,Q96FF9 204 7.81e-04 5 7 2 0.286 0.400 HP:0004785 hp 1 Malrotation of colon 1 Q9UQE7,O60216 204 7.81e-04 5 7 2 0.286 0.400 HP:0005217 hp 1 Duplication of internal organs 1 Q9UQE7,O60216 204 7.81e-04 5 7 2 0.286 0.400 HP:0005932 hp 1 Abnormal renal corticomedullary differentiation 1 Q9UQE7,O60216 204 7.81e-04 5 7 2 0.286 0.400 HP:0003997 hp 1 Hypoplastic radial head 1 Q9UQE7,O60216 204 9.58e-04 720 7 4 0.571 0.006 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 9.63e-04 721 7 4 0.571 0.006 GO:0000278 BP 1 mitotic cell cycle 1 Q7Z5K2,Q9UQE7,Q96FF9,O60216 204 9.77e-04 55 7 2 0.286 0.036 GO:0000794 CC 1 condensed nuclear chromosome 1 Q7Z5K2,O60216 204 1.08e-03 781 7 4 0.571 0.005 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.17e-03 6 7 2 0.286 0.333 HP:0007665 hp 1 Curly eyelashes 1 Q9UQE7,O60216 204 1.28e-03 1 7 1 0.143 1.000 GO:0060623 BP 1 regulation of chromosome condensation 1 Q7Z5K2 204 1.36e-03 65 7 2 0.286 0.031 GO:0051099 BP 1 positive regulation of binding 1 Q7Z5K2,Q96FF9 204 1.37e-03 832 7 4 0.571 0.005 HPA:009030_03 hpa 1 colon; peripheral nerve/ganglion[Uncertain,High] 1 Q8N3U4,Q9UQE7,Q96FF9,O60216 204 1.64e-03 7 7 2 0.286 0.286 HP:0002580 hp 1 Volvulus 1 Q9UQE7,O60216 204 1.83e-03 347 7 3 0.429 0.009 GO:0044702 BP 1 single organism reproductive process 1 Q7Z5K2,Q9UQE7,O60216 204 1.97e-03 2707 7 6 0.857 0.002 GO:0005829 CC 1 cytosol 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.98e-03 357 7 3 0.429 0.008 GO:0044454 CC 1 nuclear chromosome part 1 Q7Z5K2,Q96FF9,O60216 204 2.18e-03 8 7 2 0.286 0.250 HP:0040082 hp 1 Happy demeanor 1 Q9UQE7,O60216 204 2.31e-03 376 7 3 0.429 0.008 GO:0045786 BP 1 negative regulation of cell cycle 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.35e-03 958 7 4 0.571 0.004 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.40e-03 416 7 3 0.429 0.007 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 Q8N3U4,Q8WVM7,O60216 204 2.43e-03 383 7 3 0.429 0.008 GO:0000228 CC 1 nuclear chromosome 1 Q7Z5K2,Q96FF9,O60216 204 2.53e-03 388 7 3 0.429 0.008 GO:0022414 BP 1 reproductive process 1 Q7Z5K2,Q9UQE7,O60216 204 2.55e-03 389 7 3 0.429 0.008 GO:0000003 BP 1 reproduction 1 Q7Z5K2,Q9UQE7,O60216 204 2.57e-03 2 7 1 0.143 0.500 GO:0034991 CC 1 nuclear meiotic cohesin complex 1 O60216 204 2.57e-03 2 7 1 0.143 0.500 GO:0051754 BP 1 meiotic sister chromatid cohesion, centromeric 1 O60216 204 2.60e-03 4430 7 7 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.78e-03 1002 7 4 0.571 0.004 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.04e-03 114 7 2 0.286 0.018 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q8WVM7,O60216 204 3.15e-03 2974 7 6 0.857 0.002 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.49e-03 10 7 2 0.286 0.200 HP:0009829 hp 1 Phocomelia 1 Q9UQE7,O60216 204 3.83e-03 1091 7 4 0.571 0.004 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.85e-03 3 7 1 0.143 0.333 GO:0051177 BP 1 meiotic sister chromatid cohesion 1 O60216 204 3.85e-03 3 7 1 0.143 0.333 GO:0035562 BP 1 negative regulation of chromatin binding 1 Q7Z5K2 204 3.85e-03 3 7 1 0.143 0.333 GO:0031536 BP 1 positive regulation of exit from mitosis 1 Q96FF9 204 3.88e-03 110 7 2 0.286 0.018 GO:0006323 BP 1 DNA packaging 1 Q7Z5K2,Q96FF9 204 3.95e-03 1100 7 4 0.571 0.004 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.95e-03 495 7 3 0.429 0.006 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 Q8WVM7,Q96FF9,O60216 204 4.04e-03 1107 7 4 0.571 0.004 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.09e-03 3113 7 6 0.857 0.002 HPA:039030_02 hpa 1 soft tissue 1; fibroblasts[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.27e-03 11 7 2 0.286 0.182 HP:0002036 hp 1 Hiatus hernia 1 Q9UQE7,O60216 204 4.30e-03 136 7 2 0.286 0.015 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q8N3U4,O60216 204 4.53e-03 119 7 2 0.286 0.017 GO:0006261 BP 1 DNA-dependent DNA replication 1 Q8N3U4,Q9UQE7 204 4.97e-03 2051 7 5 0.714 0.002 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,Q96FF9,O60216 204 5.01e-03 147 7 2 0.286 0.014 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q8WVM7,O60216 204 5.07e-03 148 7 2 0.286 0.014 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q8WVM7,O60216 204 5.11e-03 1179 7 4 0.571 0.003 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 5.13e-03 4 7 1 0.143 0.250 GO:0045875 BP 1 negative regulation of sister chromatid cohesion 1 Q7Z5K2 204 5.13e-03 4 7 1 0.143 0.250 GO:0007135 BP 1 meiosis II 1 O60216 204 5.13e-03 4 7 1 0.143 0.250 GO:0045144 BP 1 meiotic sister chromatid segregation 1 O60216 204 5.31e-03 549 7 3 0.429 0.005 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 Q8WVM7,Q96FF9,O60216 204 5.62e-03 3293 7 6 0.857 0.002 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.91e-03 160 7 2 0.286 0.013 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 Q8N3U4,O60216 204 5.97e-03 3328 7 6 0.857 0.002 HPA:004010_01 hpa 1 breast; adipocytes[Uncertain,Low] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 5.98e-03 1230 7 4 0.571 0.003 HPA:041010_12 hpa 1 spleen; cells in red pulp[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 6.20e-03 1242 7 4 0.571 0.003 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 6.29e-03 1247 7 4 0.571 0.003 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 6.32e-03 2096 7 5 0.714 0.002 GO:0043234 CC 1 protein complex 1 Q7Z5K2,Q8NDV3,Q9UQE7,Q96FF9,O60216 204 6.81e-03 1274 7 4 0.571 0.003 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 7.44e-03 153 7 2 0.286 0.013 GO:0071103 BP 1 DNA conformation change 1 Q7Z5K2,Q96FF9 204 7.49e-03 1307 7 4 0.571 0.003 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 7.51e-03 1308 7 4 0.571 0.003 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 7.53e-03 154 7 2 0.286 0.013 GO:0006302 BP 1 double-strand break repair 1 Q96FF9,O60216 204 7.69e-03 6 7 1 0.143 0.167 GO:0035561 BP 1 regulation of chromatin binding 1 Q7Z5K2 204 7.69e-03 6 7 1 0.143 0.167 GO:0070601 BP 1 centromeric sister chromatid cohesion 1 O60216 204 7.82e-03 157 7 2 0.286 0.013 GO:0051098 BP 1 regulation of binding 1 Q7Z5K2,Q96FF9 204 7.99e-03 634 7 3 0.429 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q7Z5K2,Q8WVM7,O60216 204 8.11e-03 712 7 4 0.571 0.006 REAC:597592 rea 1 Post-translational protein modification 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 8.12e-03 160 7 2 0.286 0.013 GO:0090068 BP 1 positive regulation of cell cycle process 1 Q96FF9,O60216 204 8.14e-03 1337 7 4 0.571 0.003 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 8.17e-03 639 7 3 0.429 0.005 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 Q7Z5K2,Q8WVM7,O60216 204 8.66e-03 1360 7 4 0.571 0.003 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 8.87e-03 658 7 3 0.429 0.005 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 8.95e-03 1372 7 4 0.571 0.003 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 9.13e-03 200 7 2 0.286 0.010 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 Q8WVM7,O60216 204 9.25e-03 16 7 2 0.286 0.125 HP:0001180 hp 1 Hand oligodactyly 1 Q9UQE7,O60216 204 9.25e-03 16 7 2 0.286 0.125 HP:0002557 hp 1 Hypoplastic nipples 1 Q9UQE7,O60216 204 9.54e-03 1396 7 4 0.571 0.003 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 9.54e-03 1396 7 4 0.571 0.003 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.01e-02 1419 7 4 0.571 0.003 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.03e-02 8 7 1 0.143 0.125 GO:0045876 BP 1 positive regulation of sister chromatid cohesion 1 O60216 204 1.03e-02 5381 7 7 1.000 0.001 HPA:004010 hpa 1 breast; adipocytes 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.05e-02 17 7 2 0.286 0.118 HP:0008428 hp 1 Vertebral clefting 1 Q9UQE7,O60216 204 1.10e-02 1453 7 4 0.571 0.003 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.11e-02 221 7 2 0.286 0.009 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 Q8WVM7,O60216 204 1.12e-02 1459 7 4 0.571 0.003 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.15e-02 657 7 3 0.429 0.005 GO:0033365 BP 1 protein localization to organelle 1 Q7Z5K2,Q96FF9,O60216 204 1.15e-02 1470 7 4 0.571 0.003 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.18e-02 18 7 2 0.286 0.111 HP:0005815 hp 1 Supernumerary ribs 1 Q9UQE7,O60216 204 1.18e-02 18 7 2 0.286 0.111 HP:0000879 hp 1 Short sternum 1 Q9UQE7,O60216 204 1.19e-02 730 7 3 0.429 0.004 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 1.22e-02 1492 7 4 0.571 0.003 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.24e-02 1499 7 4 0.571 0.003 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.28e-02 1513 7 4 0.571 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.29e-02 753 7 3 0.429 0.004 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q8N3U4,Q8WVM7,O60216 204 1.30e-02 755 7 3 0.429 0.004 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 1.31e-02 19 7 2 0.286 0.105 HP:0009144 hp 1 Supernumerary bones of the axial skeleton 1 Q9UQE7,O60216 204 1.35e-02 1535 7 4 0.571 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.41e-02 707 7 3 0.429 0.004 GO:0033043 BP 1 regulation of organelle organization 1 Q7Z5K2,Q96FF9,O60216 204 1.44e-02 215 7 2 0.286 0.009 GO:0045787 BP 1 positive regulation of cell cycle 1 Q96FF9,O60216 204 1.45e-02 3899 7 6 0.857 0.002 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.46e-02 3902 7 6 0.857 0.002 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.46e-02 20 7 2 0.286 0.100 HP:0000059 hp 1 Hypoplastic labia majora 1 Q9UQE7,O60216 204 1.46e-02 20 7 2 0.286 0.100 HP:0010880 hp 1 Increased nuchal translucency 1 Q9UQE7,O60216 204 1.48e-02 1574 7 4 0.571 0.003 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.48e-02 1576 7 4 0.571 0.003 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.51e-02 1583 7 4 0.571 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.53e-02 1589 7 4 0.571 0.003 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.53e-02 1589 7 4 0.571 0.003 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.53e-02 3882 7 6 0.857 0.002 GO:0016043 BP 1 cellular component organization 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.53e-02 5691 7 7 1.000 0.001 HPA:039010 hpa 1 soft tissue 1; adipocytes 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.53e-02 3939 7 6 0.857 0.002 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.54e-02 12 7 1 0.143 0.083 GO:0007076 BP 1 mitotic chromosome condensation 1 Q96FF9 204 1.57e-02 265 7 2 0.286 0.008 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 Q8WVM7,O60216 204 1.61e-02 21 7 2 0.286 0.095 HP:0009623 hp 1 Proximal placement of thumb 1 Q9UQE7,O60216 204 1.61e-02 21 7 2 0.286 0.095 HP:0001377 hp 1 Limited elbow extension 1 Q9UQE7,O60216 204 1.61e-02 21 7 2 0.286 0.095 HP:0012881 hp 1 Abnormality of the labia majora 1 Q9UQE7,O60216 204 1.63e-02 1619 7 4 0.571 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.64e-02 1621 7 4 0.571 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.64e-02 1622 7 4 0.571 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.64e-02 1622 7 4 0.571 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.65e-02 1623 7 4 0.571 0.002 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.66e-02 13 7 1 0.143 0.077 GO:0007096 BP 1 regulation of exit from mitosis 1 Q96FF9 204 1.68e-02 753 7 3 0.429 0.004 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 1.68e-02 1633 7 4 0.571 0.002 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.69e-02 5787 7 7 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.71e-02 4019 7 6 0.857 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.73e-02 836 7 3 0.429 0.004 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 Q7Z5K2,Q8WVM7,O60216 204 1.76e-02 765 7 3 0.429 0.004 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 1.78e-02 1659 7 4 0.571 0.002 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.79e-02 240 7 2 0.286 0.008 GO:0003682 MF 1 chromatin binding 1 Q96FF9,O60216 204 1.80e-02 1663 7 4 0.571 0.002 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 Q8N3U4,Q8WVM7,Q96FF9,O60216 204 1.81e-02 1666 7 4 0.571 0.002 HPA:040040_02 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Medium] 1 Q7Z5K2,Q8WVM7,Q96FF9,O60216 204 1.83e-02 1670 7 4 0.571 0.002 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.84e-02 4013 7 6 0.857 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.86e-02 858 7 3 0.429 0.003 HPA:009010_03 hpa 1 colon; endothelial cells[Uncertain,High] 1 Q8N3U4,Q96FF9,O60216 204 1.88e-02 5877 7 7 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 1.91e-02 867 7 3 0.429 0.003 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q8N3U4,Q8WVM7,O60216 204 1.93e-02 23 7 2 0.286 0.087 HP:0100777 hp 1 Exostoses 1 Q9UQE7,O60216 204 1.93e-02 23 7 2 0.286 0.087 HP:0012165 hp 1 Oligodactyly 1 Q9UQE7,O60216 204 1.93e-02 23 7 2 0.286 0.087 HP:0009603 hp 1 Deviation of the thumb 1 Q9UQE7,O60216 204 1.95e-02 794 7 3 0.429 0.004 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 1.96e-02 1704 7 4 0.571 0.002 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 1.97e-02 298 7 2 0.286 0.007 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 Q8N3U4,O60216 204 1.97e-02 877 7 3 0.429 0.003 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 1.97e-02 1707 7 4 0.571 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.08e-02 307 7 2 0.286 0.007 HPA:004010_03 hpa 1 breast; adipocytes[Uncertain,High] 1 Q8WVM7,O60216 204 2.15e-02 822 7 3 0.429 0.004 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.18e-02 1756 7 4 0.571 0.002 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.22e-02 1765 7 4 0.571 0.002 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.24e-02 834 7 3 0.429 0.004 GO:0009890 BP 1 negative regulation of biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.24e-02 1769 7 4 0.571 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.26e-02 4225 7 6 0.857 0.001 HPA:046010_02 hpa 1 tonsil; germinal center cells[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.29e-02 25 7 2 0.286 0.080 HP:0000066 hp 1 Labial hypoplasia 1 Q9UQE7,O60216 204 2.29e-02 1780 7 4 0.571 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.30e-02 1782 7 4 0.571 0.002 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.32e-02 930 7 3 0.429 0.003 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q7Z5K2,Q8WVM7,O60216 204 2.33e-02 1787 7 4 0.571 0.002 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.33e-02 1788 7 4 0.571 0.002 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.37e-02 1797 7 4 0.571 0.002 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.37e-02 852 7 3 0.429 0.004 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7 204 2.40e-02 1803 7 4 0.571 0.002 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.40e-02 942 7 3 0.429 0.003 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q7Z5K2,Q8WVM7,O60216 204 2.43e-02 333 7 2 0.286 0.006 HPA:020010_13 hpa 1 lateral ventricle; glial cells[Supportive,High] 1 Q8WVM7,O60216 204 2.45e-02 1813 7 4 0.571 0.002 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.47e-02 1818 7 4 0.571 0.002 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.47e-02 26 7 2 0.286 0.077 HP:0012815 hp 1 Hypoplastic female external genitalia 1 Q9UQE7,O60216 204 2.47e-02 26 7 2 0.286 0.077 HP:0001612 hp 1 Weak cry 1 Q9UQE7,O60216 204 2.48e-02 1820 7 4 0.571 0.002 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.48e-02 4298 7 6 0.857 0.001 HPA:009010_02 hpa 1 colon; endothelial cells[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.51e-02 1825 7 4 0.571 0.002 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.56e-02 20 7 1 0.143 0.050 GO:0051984 BP 1 positive regulation of chromosome segregation 1 O60216 204 2.56e-02 965 7 3 0.429 0.003 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q8N3U4,Q8WVM7,O60216 204 2.59e-02 969 7 3 0.429 0.003 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 2.66e-02 1857 7 4 0.571 0.002 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.67e-02 27 7 2 0.286 0.074 HP:0006714 hp 1 Aplasia/Hypoplasia of the sternum 1 Q9UQE7,O60216 204 2.67e-02 27 7 2 0.286 0.074 HP:0004691 hp 1 2-3 toe syndactyly 1 Q9UQE7,O60216 204 2.69e-02 351 7 2 0.286 0.006 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 Q8WVM7,O60216 204 2.69e-02 1863 7 4 0.571 0.002 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.70e-02 352 7 2 0.286 0.006 HPA:039010_03 hpa 1 soft tissue 1; adipocytes[Uncertain,High] 1 Q8N3U4,O60216 204 2.78e-02 1880 7 4 0.571 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.80e-02 1883 7 4 0.571 0.002 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.81e-02 1885 7 4 0.571 0.002 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.85e-02 4407 7 6 0.857 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 2.87e-02 363 7 2 0.286 0.006 HPA:026020_03 hpa 1 ovary; ovarian stroma cells[Uncertain,High] 1 Q96FF9,O60216 204 2.87e-02 28 7 2 0.286 0.071 HP:0006709 hp 1 Aplasia/Hypoplasia of the nipples 1 Q9UQE7,O60216 204 2.91e-02 1904 7 4 0.571 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.94e-02 1909 7 4 0.571 0.002 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 2.94e-02 23 7 1 0.143 0.043 GO:0045502 MF 1 dynein binding 1 Q9UQE7 204 2.94e-02 23 7 1 0.143 0.043 GO:0070192 BP 1 chromosome organization involved in meiotic cell cycle 1 O60216 204 2.96e-02 369 7 2 0.286 0.005 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 Q8N3U4,O60216 204 3.02e-02 1924 7 4 0.571 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.06e-02 1932 7 4 0.571 0.002 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.06e-02 1932 7 4 0.571 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.06e-02 24 7 1 0.143 0.042 GO:0010458 BP 1 exit from mitosis 1 Q96FF9 204 3.07e-02 1933 7 4 0.571 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.16e-02 1950 7 4 0.571 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.19e-02 384 7 2 0.286 0.005 HPA:040010_03 hpa 1 soft tissue 2; adipocytes[Uncertain,High] 1 Q8N3U4,O60216 204 3.19e-02 25 7 1 0.143 0.040 GO:0045840 BP 1 positive regulation of mitotic nuclear division 1 Q96FF9 204 3.29e-02 397 7 3 0.429 0.008 MI:hsa-miR-579 mi 1 MI:hsa-miR-579 1 Q8NDV3,Q8N3U4,Q8WVM7 204 3.30e-02 1974 7 4 0.571 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.31e-02 3013 7 5 0.714 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q96FF9,O60216 204 3.37e-02 1985 7 4 0.571 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q8N3U4,Q8WVM7,Q96FF9,O60216 204 3.39e-02 1989 7 4 0.571 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.40e-02 1990 7 4 0.571 0.002 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.43e-02 1996 7 4 0.571 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.44e-02 1998 7 4 0.571 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.46e-02 1078 7 3 0.429 0.003 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 Q7Z5K2,Q8N3U4,O60216 204 3.46e-02 1078 7 3 0.429 0.003 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q8N3U4,Q8WVM7,O60216 204 3.49e-02 403 7 2 0.286 0.005 HPA:007010_03 hpa 1 cerebral cortex; endothelial cells[Uncertain,High] 1 Q8WVM7,O60216 204 3.60e-02 2024 7 4 0.571 0.002 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.62e-02 2026 7 4 0.571 0.002 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.68e-02 4125 7 7 1.000 0.002 TF:M03850_1 tf 1 Factor: Sox5; motif: TTGTTTN; match class: 1 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 3.70e-02 29 7 1 0.143 0.034 GO:0051785 BP 1 positive regulation of nuclear division 1 Q96FF9 204 3.70e-02 29 7 1 0.143 0.034 GO:0033046 BP 1 negative regulation of sister chromatid segregation 1 Q7Z5K2 204 3.70e-02 2039 7 4 0.571 0.002 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.72e-02 2043 7 4 0.571 0.002 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.73e-02 1923 7 4 0.571 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,O60216 204 3.73e-02 3208 7 5 0.714 0.002 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 3.76e-02 2049 7 4 0.571 0.002 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.77e-02 2051 7 4 0.571 0.002 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.80e-02 2055 7 4 0.571 0.002 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.82e-02 30 7 1 0.143 0.033 GO:0051985 BP 1 negative regulation of chromosome segregation 1 Q7Z5K2 204 3.84e-02 3228 7 5 0.714 0.002 HPA:037010_03 hpa 1 small intestine; glandular cells[Uncertain,High] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q96FF9,O60216 204 3.89e-02 360 7 2 0.286 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 Q96FF9,O60216 204 3.90e-02 2071 7 4 0.571 0.002 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.91e-02 2072 7 4 0.571 0.002 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 3.94e-02 3247 7 5 0.714 0.002 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 3.95e-02 31 7 1 0.143 0.032 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 Q96FF9 204 3.95e-02 1133 7 3 0.429 0.003 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q7Z5K2,Q8N3U4,O60216 204 3.97e-02 1135 7 3 0.429 0.003 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q8N3U4,Q8WVM7,O60216 204 3.98e-02 33 7 2 0.286 0.061 HP:0002937 hp 1 Hemivertebrae 1 Q9UQE7,O60216 204 3.98e-02 33 7 2 0.286 0.061 HP:0000498 hp 1 Blepharitis 1 Q9UQE7,O60216 204 4.00e-02 2086 7 4 0.571 0.002 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.04e-02 2092 7 4 0.571 0.002 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.06e-02 368 7 2 0.286 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 Q7Z5K2,Q96FF9 204 4.10e-02 1976 7 4 0.571 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,O60216 204 4.11e-02 2102 7 4 0.571 0.002 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q7Z5K2,Q8NDV3,Q8WVM7,O60216 204 4.16e-02 2110 7 4 0.571 0.002 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.23e-02 2119 7 4 0.571 0.002 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.24e-02 1994 7 4 0.571 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,O60216 204 4.30e-02 2130 7 4 0.571 0.002 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.33e-02 34 7 1 0.143 0.029 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 Q96FF9 204 4.33e-02 34 7 1 0.143 0.029 GO:0007131 BP 1 reciprocal meiotic recombination 1 O60216 204 4.33e-02 34 7 1 0.143 0.029 GO:0035825 BP 1 reciprocal DNA recombination 1 O60216 204 4.36e-02 454 7 2 0.286 0.004 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q8WVM7,O60216 204 4.36e-02 2139 7 4 0.571 0.002 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.36e-02 2139 7 4 0.571 0.002 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.37e-02 3326 7 5 0.714 0.002 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.40e-02 384 7 2 0.286 0.005 GO:0006281 BP 1 DNA repair 1 Q96FF9,O60216 204 4.41e-02 3334 7 5 0.714 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.45e-02 2151 7 4 0.571 0.002 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.45e-02 35 7 1 0.143 0.029 GO:0005604 CC 1 basement membrane 1 Q9UQE7 204 4.46e-02 2153 7 4 0.571 0.002 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.47e-02 2154 7 4 0.571 0.002 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.47e-02 3344 7 5 0.714 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.47e-02 3344 7 5 0.714 0.001 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.51e-02 2159 7 4 0.571 0.002 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.55e-02 2165 7 4 0.571 0.002 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q8N3U4,Q8WVM7,Q96FF9,O60216 204 4.57e-02 3361 7 5 0.714 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.57e-02 2168 7 4 0.571 0.002 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.57e-02 6671 7 7 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.60e-02 6661 7 7 1.000 0.001 HPA:040030 hpa 1 soft tissue 2; fibroblasts 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.61e-02 3368 7 5 0.714 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.62e-02 3370 7 5 0.714 0.001 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.63e-02 2176 7 4 0.571 0.002 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.68e-02 3379 7 5 0.714 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.68e-02 2183 7 4 0.571 0.002 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.72e-02 2188 7 4 0.571 0.002 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.72e-02 3386 7 5 0.714 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.72e-02 3386 7 5 0.714 0.001 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.74e-02 2191 7 4 0.571 0.002 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.74e-02 3390 7 5 0.714 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.77e-02 6694 7 7 1.000 0.001 HPA:039030 hpa 1 soft tissue 1; fibroblasts 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.78e-02 2197 7 4 0.571 0.002 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.82e-02 2068 7 4 0.571 0.002 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,O60216 204 4.82e-02 3403 7 5 0.714 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.82e-02 2202 7 4 0.571 0.002 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.83e-02 4858 7 6 0.857 0.001 HPA:040030_01 hpa 1 soft tissue 2; fibroblasts[Uncertain,Low] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.83e-02 3405 7 5 0.714 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.85e-02 3407 7 5 0.714 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.85e-02 3407 7 5 0.714 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.88e-02 2209 7 4 0.571 0.002 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.88e-02 3412 7 5 0.714 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.88e-02 3413 7 5 0.714 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.89e-02 3415 7 5 0.714 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.90e-02 3416 7 5 0.714 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.90e-02 3416 7 5 0.714 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.90e-02 4872 7 6 0.857 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q7Z5K2,Q8N3U4,Q9UQE7,Q8WVM7,Q96FF9,O60216 204 4.91e-02 1111 7 3 0.429 0.003 GO:0034613 BP 1 cellular protein localization 1 Q7Z5K2,Q96FF9,O60216 204 4.91e-02 3418 7 5 0.714 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.92e-02 2215 7 4 0.571 0.002 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q7Z5K2,Q8N3U4,Q8WVM7,O60216 204 4.93e-02 3420 7 5 0.714 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.93e-02 3421 7 5 0.714 0.001 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.94e-02 3422 7 5 0.714 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.94e-02 3422 7 5 0.714 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.94e-02 3423 7 5 0.714 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.94e-02 3423 7 5 0.714 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.95e-02 3424 7 5 0.714 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.96e-02 3426 7 5 0.714 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.96e-02 3426 7 5 0.714 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.98e-02 3428 7 5 0.714 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.98e-02 3429 7 5 0.714 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.98e-02 3429 7 5 0.714 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.98e-02 3429 7 5 0.714 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3430 7 5 0.714 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 4.99e-02 3431 7 5 0.714 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 37 7 2 0.286 0.054 HP:0000058 hp 1 Abnormality of the labia 1 Q9UQE7,O60216 204 5.00e-02 1 7 1 0.143 1.000 OMIM:610759 omi 1 CORNELIA DE LANGE SYNDROME 3; CDLS3 1 Q9UQE7 204 5.00e-02 2090 7 4 0.571 0.002 GO:0009889 BP 1 regulation of biosynthetic process 1 Q7Z5K2,Q8N3U4,Q9UQE7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 37 7 2 0.286 0.054 HP:0000965 hp 1 Cutis marmorata 1 Q9UQE7,O60216 204 5.00e-02 1 7 1 0.143 1.000 OMIM:614701 omi 1 CORNELIA DE LANGE SYNDROME 4; CDLS4 1 O60216 204 5.00e-02 1169 7 4 0.571 0.003 REAC:392499 rea 1 Metabolism of proteins 1 Q8N3U4,Q9UQE7,Q8WVM7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 2 7 1 0.143 0.500 CORUM:5241 cor 1 SMC1-SMC3 complex 1 Q9UQE7 204 5.00e-02 3432 7 5 0.714 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 3432 7 5 0.714 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q8WVM7,O60216 204 5.00e-02 459 7 3 0.429 0.007 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q8NDV3,Q8N3U4,O60216 204 5.00e-02 2690 7 6 0.857 0.002 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 Q7Z5K2,Q8NDV3,Q8N3U4,Q9UQE7,Q8WVM7,O60216 205 2.19e-03 306 3 2 0.667 0.007 MI:hsa-miR-223* mi 1 MI:hsa-miR-223* 1 O60739,P41214 205 6.12e-03 514 3 2 0.667 0.004 MI:hsa-miR-320 mi 1 MI:hsa-miR-320 1 O60739,P41214 205 1.93e-02 164 3 2 0.667 0.012 GO:0006413 BP 1 translational initiation 1 O60739,P41214 205 2.16e-02 9 3 1 0.333 0.111 TF:M00419_1 tf 1 Factor: MEIS1; motif: NNNTGACAGNNN; match class: 1 1 O60739 205 3.24e-02 420 3 2 0.667 0.005 TF:M06171_0 tf 1 Factor: ZNF138; motif: NCTGGCAAGANA; match class: 0 1 O60739,P41214 205 3.35e-02 14 3 1 0.333 0.071 TF:M06217_0 tf 1 Factor: ZNF169; motif: KGTTTAAGTATA; match class: 0 1 Q96CT7 205 4.07e-02 17 3 1 0.333 0.059 TF:M06107_0 tf 1 Factor: ZNF43; motif: NGGGAAAGATGC; match class: 0 1 O60739 205 5.00e-02 523 3 2 0.667 0.004 TF:M04429_1 tf 1 Factor: PITX3; motif: NNTAATCCN; match class: 1 1 Q96CT7,O60739 205 5.00e-02 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 Q96CT7,O60739,P41214 205 5.00e-02 523 3 2 0.667 0.004 TF:M07352_1 tf 1 Factor: Crx; motif: NYTAATCNN; match class: 1 1 Q96CT7,O60739 206 7.35e-12 54 10 6 0.600 0.111 GO:0048208 BP 1 COPII vesicle coating 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 7.35e-12 54 10 6 0.600 0.111 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 9.23e-12 56 10 6 0.600 0.107 GO:0006901 BP 1 vesicle coating 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.03e-11 57 10 6 0.600 0.105 GO:0090114 BP 1 COPII-coated vesicle budding 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.28e-11 59 10 6 0.600 0.102 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 2.83e-11 67 10 6 0.600 0.090 GO:0006903 BP 1 vesicle targeting 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 3.28e-11 153 10 7 0.700 0.046 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.05e-10 60 10 6 0.600 0.100 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 2.60e-10 96 10 6 0.600 0.062 GO:0006900 BP 1 membrane budding 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 9.54e-10 522 10 9 0.900 0.017 REAC:199991 rea 1 Membrane Trafficking 1 O75865,O43617,Q9Y2L5,Q9UL33,Q7Z392,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 1.50e-09 549 10 9 0.900 0.016 REAC:5653656 rea 1 Vesicle-mediated transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q7Z392,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 2.22e-09 278 10 7 0.700 0.025 GO:0048193 BP 1 Golgi vesicle transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 2.91e-09 289 10 7 0.700 0.024 GO:0051656 BP 1 establishment of organelle localization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 7.10e-09 119 10 6 0.600 0.050 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 7.30e-09 166 10 6 0.600 0.036 GO:0051650 BP 1 establishment of vesicle localization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 7.53e-09 331 10 7 0.700 0.021 GO:0051640 BP 1 organelle localization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 8.43e-09 4 10 3 0.300 0.750 GO:0030008 CC 1 TRAPP complex 1 Q9Y2L5,Q9Y5R8,Q9Y296 206 1.00e-08 175 10 6 0.600 0.034 GO:0051648 BP 1 vesicle localization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 2.07e-08 142 10 6 0.600 0.042 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.72e-07 281 10 6 0.600 0.021 GO:0016050 BP 1 vesicle organization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 5.84e-07 248 10 6 0.600 0.024 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 4.78e-06 842 10 7 0.700 0.008 GO:0070271 BP 1 protein complex biogenesis 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 4.78e-06 842 10 7 0.700 0.008 GO:0006461 BP 1 protein complex assembly 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 1.15e-05 958 10 7 0.700 0.007 GO:0016192 BP 1 vesicle-mediated transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.23e-05 1493 10 8 0.800 0.005 GO:0051649 BP 1 establishment of localization in cell 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 1.70e-05 1015 10 7 0.700 0.007 GO:0071822 BP 1 protein complex subunit organization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 2.74e-05 44 10 3 0.300 0.068 GO:0099023 CC 1 tethering complex 1 Q9Y2L5,Q9Y5R8,Q9Y296 206 3.17e-05 1113 10 7 0.700 0.006 GO:0065003 BP 1 macromolecular complex assembly 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 3.45e-05 1706 10 8 0.800 0.005 GO:0022607 BP 1 cellular component assembly 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 5.53e-05 749 10 6 0.600 0.008 GO:0061024 BP 1 membrane organization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 6.07e-05 1836 10 8 0.800 0.004 GO:0051641 BP 1 cellular localization 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 6.45e-05 1237 10 7 0.700 0.006 GO:0046907 BP 1 intracellular transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 8.97e-05 1932 10 8 0.800 0.004 GO:0044085 BP 1 cellular component biogenesis 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 2.70e-04 712 10 6 0.600 0.008 REAC:597592 rea 1 Post-translational protein modification 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 2.99e-04 2262 10 8 0.800 0.004 GO:0006996 BP 1 organelle organization 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 3.79e-04 1614 10 7 0.700 0.004 GO:0043933 BP 1 macromolecular complex subunit organization 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 1.13e-03 28 10 2 0.200 0.071 GO:0017112 MF 1 Rab guanyl-nucleotide exchange factor activity 1 Q9Y5R8,Q9Y296 206 1.30e-03 2748 10 8 0.800 0.003 GO:0051234 BP 1 establishment of localization 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 3.89e-03 1 10 1 0.100 1.000 GO:0090233 BP 1 negative regulation of spindle checkpoint 1 Q8WVT3 206 3.89e-03 1 10 1 0.100 1.000 GO:1990072 CC 1 TRAPPIII protein complex 1 Q9Y2L5 206 3.89e-03 1 10 1 0.100 1.000 GO:1902426 BP 1 deactivation of mitotic spindle assembly checkpoint 1 Q8WVT3 206 4.18e-03 1169 10 6 0.600 0.005 REAC:392499 rea 1 Metabolism of proteins 1 O75865,O43617,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 6.27e-03 3401 10 8 0.800 0.002 GO:0051179 BP 1 localization 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 7.78e-03 2 10 1 0.100 0.500 GO:0032258 BP 1 CVT pathway 1 Q9Y2L5 206 7.78e-03 2 10 1 0.100 0.500 GO:1905340 BP 1 regulation of protein localization to kinetochore 1 Q8WVT3 206 7.78e-03 2 10 1 0.100 0.500 GO:1905342 BP 1 positive regulation of protein localization to kinetochore 1 Q8WVT3 206 9.14e-03 2644 10 7 0.700 0.003 GO:0006810 BP 1 transport 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0,Q9Y296 206 1.17e-02 3 10 1 0.100 0.333 GO:0090234 BP 1 regulation of kinetochore assembly 1 Q8WVT3 206 1.56e-02 4 10 1 0.100 0.250 GO:0030242 BP 1 pexophagy 1 Q9Y2L5 206 1.56e-02 4 10 1 0.100 0.250 GO:1901977 BP 1 negative regulation of cell cycle checkpoint 1 Q8WVT3 206 1.56e-02 4 10 1 0.100 0.250 GO:0090230 BP 1 regulation of centromere complex assembly 1 Q8WVT3 206 1.63e-02 3882 10 8 0.800 0.002 GO:0016043 BP 1 cellular component organization 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 1.71e-02 1175 10 4 0.400 0.003 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 O43617,Q9UL33,Q9Y5R8,Q8WVT3 206 2.07e-02 4013 10 8 0.800 0.002 GO:0071840 BP 1 cellular component organization or biogenesis 1 O75865,O43617,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0,Q9Y296 206 2.33e-02 6 10 1 0.100 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q8WVT3 206 2.33e-02 6 10 1 0.100 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q8WVT3 206 2.33e-02 6 10 1 0.100 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q8WVT3 206 2.97e-02 145 10 2 0.200 0.014 GO:0005088 MF 1 Ras guanyl-nucleotide exchange factor activity 1 Q9Y5R8,Q9Y296 206 3.67e-02 10 10 1 0.100 0.100 HP:0006785 hp 1 Limb-girdle muscular dystrophy 1 Q7Z392 206 3.88e-02 10 10 1 0.100 0.100 GO:0034497 BP 1 protein localization to pre-autophagosomal structure 1 Q9Y2L5 206 4.27e-02 11 10 1 0.100 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q8WVT3 206 4.27e-02 11 10 1 0.100 0.091 GO:0051382 BP 1 kinetochore assembly 1 Q8WVT3 206 4.27e-02 11 10 1 0.100 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q8WVT3 206 4.65e-02 12 10 1 0.100 0.083 GO:0051383 BP 1 kinetochore organization 1 Q8WVT3 206 4.94e-02 3269 10 6 0.600 0.002 HPA:010010_03 hpa 1 duodenum; glandular cells[Uncertain,High] 1 O75865,O43617,Q9Y2L5,Q8WVT3,Q8IUR0,Q9Y296 206 5.00e-02 680 10 5 0.500 0.007 TF:M04194_1 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 1 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 206 5.00e-02 1 10 1 0.100 1.000 OMIM:615356 omi 1 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2S; LGMD2S 1 Q7Z392 206 5.00e-02 18 10 1 0.100 0.056 REAC:3000170 rea 1 Syndecan interactions 1 Q9Y296 206 5.00e-02 414 10 4 0.400 0.010 MI:hsa-miR-631 mi 1 MI:hsa-miR-631 1 O43617,Q8WVT3,Q8IUR0,Q9Y296 207 4.08e-02 324 1 1 1.000 0.003 MI:hsa-miR-379* mi 1 MI:hsa-miR-379* 1 Q9BZF9 207 5.00e-02 397 1 1 1.000 0.003 MI:mmu-miR-201 mi 1 MI:mmu-miR-201 1 Q9BZF9 207 5.00e-02 15 1 1 1.000 0.067 TF:M06239_0 tf 1 Factor: ZNF844; motif: NAGTCATTTTTC; match class: 0 1 Q9BZF9 208 4.96e-05 7 4 2 0.500 0.286 GO:0070070 BP 1 proton-transporting V-type ATPase complex assembly 1 Q13488,Q3ZAQ7 208 4.96e-05 7 4 2 0.500 0.286 GO:0070072 BP 1 vacuolar proton-transporting V-type ATPase complex assembly 1 Q13488,Q3ZAQ7 208 1.30e-04 11 4 2 0.500 0.182 GO:0070071 BP 1 proton-transporting two-sector ATPase complex assembly 1 Q13488,Q3ZAQ7 208 5.02e-03 331 4 2 0.500 0.006 MI:hsa-miR-16-1* mi 1 MI:hsa-miR-16-1* 1 Q8WV92,Q3ZAQ7 208 5.36e-03 342 4 2 0.500 0.006 MI:hsa-miR-656 mi 1 MI:hsa-miR-656 1 Q8WV92,O75787 208 1.01e-02 472 4 2 0.500 0.004 MI:hsa-miR-133a mi 1 MI:hsa-miR-133a 1 Q3ZAQ7,O75787 208 1.01e-02 473 4 2 0.500 0.004 MI:hsa-miR-133b mi 1 MI:hsa-miR-133b 1 Q3ZAQ7,O75787 208 1.25e-02 2 4 1 0.250 0.500 TF:M04462_1 tf 1 Factor: ESRRG; motif: TCAAGGTCAN; match class: 1 1 O75787 208 1.25e-02 1 4 1 0.250 1.000 OMIM:300911 omi 1 PARKINSONISM WITH SPASTICITY, X-LINKED; XPDS 1 O75787 208 1.25e-02 1 4 1 0.250 1.000 OMIM:300423 omi 1 MENTAL RETARDATION, X-LINKED, SYNDROMIC, HEDERA TYPE; MRXSH;;MENTAL RETARDATION, X-LINKED, WITH EPILEPSY; MRXE 1 O75787 208 1.25e-02 1 4 1 0.250 1.000 OMIM:310440 omi 1 MYOPATHY, X-LINKED, WITH EXCESSIVE AUTOPHAGY; MEAX;;XMEA 1 Q3ZAQ7 208 1.82e-02 2 4 1 0.250 0.500 GO:0032914 BP 1 positive regulation of transforming growth factor beta1 production 1 O75787 208 2.12e-02 11 4 1 0.250 0.091 REAC:2022377 rea 1 Metabolism of Angiotensinogen to Angiotensins 1 O75787 208 2.73e-02 3 4 1 0.250 0.333 GO:0021903 BP 1 rostrocaudal neural tube patterning 1 O75787 208 3.63e-02 4 4 1 0.250 0.250 GO:0007039 BP 1 protein catabolic process in the vacuole 1 Q13488 208 3.63e-02 4 4 1 0.250 0.250 GO:0032905 BP 1 transforming growth factor beta1 production 1 O75787 208 3.63e-02 4 4 1 0.250 0.250 GO:0071636 BP 1 positive regulation of transforming growth factor beta production 1 O75787 208 3.63e-02 4 4 1 0.250 0.250 GO:0032908 BP 1 regulation of transforming growth factor beta1 production 1 O75787 208 3.75e-02 6 4 1 0.250 0.167 TF:M06702_0 tf 1 Factor: ZNF226; motif: CAGACGARGACC; match class: 0 1 Q3ZAQ7 208 4.23e-02 22 4 1 0.250 0.045 REAC:77387 rea 1 Insulin receptor recycling 1 Q13488 208 4.38e-02 7 4 1 0.250 0.143 TF:M06758_0 tf 1 Factor: ZFP-37; motif: NTGTAAARGTSC; match class: 0 1 Q3ZAQ7 208 4.54e-02 5 4 1 0.250 0.200 GO:0030127 CC 1 COPII vesicle coat 1 Q3ZAQ7 208 4.54e-02 5 4 1 0.250 0.200 GO:0048069 BP 1 eye pigmentation 1 O75787 208 4.81e-02 25 4 1 0.250 0.040 REAC:917977 rea 1 Transferrin endocytosis and recycling 1 Q13488 208 5.00e-02 26 4 1 0.250 0.038 REAC:1222556 rea 1 ROS, RNS production in response to bacteria 1 Q13488 208 5.00e-02 2412 4 4 1.000 0.002 GO:0044425 CC 1 membrane part 1 Q13488,Q8WV92,Q3ZAQ7,O75787 208 5.00e-02 4 4 1 0.250 0.250 OMIM:259700 omi 1 Autosomal Recessive Osteopetrosis 1 Q13488 208 5.00e-02 15 4 1 0.250 0.067 KEGG:04614 keg 1 Renin-angiotensin system 1 O75787 208 5.00e-02 2 4 1 0.250 0.500 HP:0005549 hp 1 Congenital neutropenia 1 Q13488 208 5.00e-02 2 4 1 0.250 0.500 HP:0005541 hp 1 Congenital agranulocytosis 1 Q13488 208 5.00e-02 2 4 1 0.250 0.500 HP:0012234 hp 1 Agranulocytosis 1 Q13488 209 6.01e-07 220 4 4 1.000 0.018 GO:0044441 CC 1 ciliary part 1 P10644,O75969,Q8N6U8,P22612 209 1.31e-06 267 4 4 1.000 0.015 GO:0005929 CC 1 cilium 1 P10644,O75969,Q8N6U8,P22612 209 7.28e-06 409 4 4 1.000 0.010 GO:0044463 CC 1 cell projection part 1 P10644,O75969,Q8N6U8,P22612 209 1.17e-05 97 4 3 0.750 0.031 REAC:5610787 rea 1 Hedgehog 'off' state 1 P10644,Q8N6U8,P22612 209 2.39e-05 123 4 3 0.750 0.024 REAC:5358351 rea 1 Signaling by Hedgehog 1 P10644,Q8N6U8,P22612 209 3.46e-05 16 4 2 0.500 0.125 REAC:163615 rea 1 PKA activation 1 P10644,P22612 209 3.92e-05 17 4 2 0.500 0.118 REAC:111931 rea 1 PKA-mediated phosphorylation of CREB 1 P10644,P22612 209 3.92e-05 17 4 2 0.500 0.118 REAC:164378 rea 1 PKA activation in glucagon signalling 1 P10644,P22612 209 5.05e-05 16 4 2 0.500 0.125 GO:0034199 BP 1 activation of protein kinase A activity 1 P10644,P22612 209 5.72e-05 17 4 2 0.500 0.118 GO:0097546 CC 1 ciliary base 1 P10644,P22612 209 6.04e-05 21 4 2 0.500 0.095 REAC:180024 rea 1 DARPP-32 events 1 P10644,P22612 209 7.35e-05 728 4 4 1.000 0.005 GO:0042995 CC 1 cell projection 1 P10644,O75969,Q8N6U8,P22612 209 8.62e-05 25 4 2 0.500 0.080 REAC:111997 rea 1 CaM pathway 1 P10644,P22612 209 8.62e-05 25 4 2 0.500 0.080 REAC:111933 rea 1 Calmodulin induced events 1 P10644,P22612 209 1.01e-04 27 4 2 0.500 0.074 REAC:111996 rea 1 Ca-dependent events 1 P10644,P22612 209 1.26e-04 25 4 2 0.500 0.080 GO:0003091 BP 1 renal water homeostasis 1 P10644,P22612 209 1.34e-04 31 4 2 0.500 0.065 REAC:1489509 rea 1 DAG and IP3 signaling 1 P10644,P22612 209 1.34e-04 31 4 2 0.500 0.065 REAC:163359 rea 1 Glucagon signaling in metabolic regulation 1 P10644,P22612 209 1.42e-04 32 4 2 0.500 0.062 REAC:167021 rea 1 PLC-gamma1 signalling 1 P10644,P22612 209 1.42e-04 32 4 2 0.500 0.062 REAC:212718 rea 1 EGFR interacts with phospholipase C-gamma 1 P10644,P22612 209 1.61e-04 34 4 2 0.500 0.059 REAC:381676 rea 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 P10644,P22612 209 1.71e-04 35 4 2 0.500 0.057 REAC:5654227 rea 1 Phospholipase C-mediated cascade; FGFR3 1 P10644,P22612 209 1.81e-04 36 4 2 0.500 0.056 REAC:5654228 rea 1 Phospholipase C-mediated cascade; FGFR4 1 P10644,P22612 209 1.81e-04 36 4 2 0.500 0.056 REAC:432040 rea 1 Vasopressin regulates renal water homeostasis via Aquaporins 1 P10644,P22612 209 1.95e-04 31 4 2 0.500 0.065 GO:0051018 MF 1 protein kinase A binding 1 P10644,O75969 209 1.95e-04 31 4 2 0.500 0.065 GO:0071377 BP 1 cellular response to glucagon stimulus 1 P10644,P22612 209 2.02e-04 38 4 2 0.500 0.053 REAC:445717 rea 1 Aquaporin-mediated transport 1 P10644,P22612 209 2.12e-04 39 4 2 0.500 0.051 REAC:5654219 rea 1 Phospholipase C-mediated cascade: FGFR1 1 P10644,P22612 209 2.12e-04 39 4 2 0.500 0.051 REAC:5654221 rea 1 Phospholipase C-mediated cascade; FGFR2 1 P10644,P22612 209 2.22e-04 33 4 2 0.500 0.061 GO:0033762 BP 1 response to glucagon 1 P10644,P22612 209 2.47e-04 42 4 2 0.500 0.048 REAC:112043 rea 1 PLC beta mediated events 1 P10644,P22612 209 2.59e-04 43 4 2 0.500 0.047 REAC:112040 rea 1 G-protein mediated events 1 P10644,P22612 209 2.95e-04 38 4 2 0.500 0.053 GO:0050891 BP 1 multicellular organismal water homeostasis 1 P10644,P22612 209 3.44e-04 41 4 2 0.500 0.049 GO:0030104 BP 1 water homeostasis 1 P10644,P22612 209 5.94e-04 65 4 2 0.500 0.031 REAC:422356 rea 1 Regulation of insulin secretion 1 P10644,P22612 209 6.22e-04 55 4 2 0.500 0.036 GO:0003014 BP 1 renal system process 1 P10644,P22612 209 7.49e-04 73 4 2 0.500 0.027 REAC:111885 rea 1 Opioid Signalling 1 P10644,P22612 209 1.24e-03 94 4 2 0.500 0.021 REAC:163685 rea 1 Integration of energy metabolism 1 P10644,P22612 209 1.62e-03 1 4 1 0.250 1.000 GO:1901620 BP 1 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1 Q8N6U8 209 1.62e-03 1 4 1 0.250 1.000 GO:1901621 BP 1 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1 Q8N6U8 209 1.62e-03 1 4 1 0.250 1.000 GO:0060831 BP 1 smoothened signaling pathway involved in dorsal/ventral neural tube patterning 1 Q8N6U8 209 1.62e-03 1 4 1 0.250 1.000 GO:0021904 BP 1 dorsal/ventral neural tube patterning 1 Q8N6U8 209 1.73e-03 529 4 3 0.750 0.006 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 P10644,Q8N6U8,P22612 209 1.73e-03 529 4 3 0.750 0.006 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 P10644,Q8N6U8,P22612 209 1.92e-03 117 4 2 0.500 0.017 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 P10644,P22612 209 3.47e-03 5 4 1 0.250 0.200 REAC:163358 rea 1 PKA-mediated phosphorylation of key metabolic factors 1 P22612 209 3.60e-03 1 4 1 0.250 1.000 OMIM:616176 omi 1 BLEEDING DISORDER, PLATELET-TYPE, 19; BDPLT19 1 P22612 209 3.60e-03 1 4 1 0.250 1.000 OMIM:160980 omi 1 CARNEY COMPLEX, TYPE 1; CNC1;;CARNEY MYXOMA-ENDOCRINE COMPLEX;;CARNEY SYNDROME; CAR;;MYXOMA, SPOTTY PIGMENTATION, AND ENDOCRINE OVERACTIVITY;;NAME SYNDROME;;LAMB SYNDROME 1 P10644 209 3.60e-03 1 4 1 0.250 1.000 OMIM:255960 omi 1 MYXOMA, INTRACARDIAC;;ATRIAL MYXOMA, FAMILIAL 1 P10644 209 3.70e-03 134 4 2 0.500 0.015 GO:0048871 BP 1 multicellular organismal homeostasis 1 P10644,P22612 209 4.86e-03 3 4 1 0.250 0.333 GO:0035686 CC 1 sperm fibrous sheath 1 O75969 209 4.86e-03 7 4 1 0.250 0.143 REAC:442720 rea 1 CREB phosphorylation through the activation of Adenylate Cyclase 1 P22612 209 4.94e-03 155 4 2 0.500 0.013 GO:0032147 BP 1 activation of protein kinase activity 1 P10644,P22612 209 5.66e-03 166 4 2 0.500 0.012 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 P10644,P22612 209 6.07e-03 172 4 2 0.500 0.012 GO:1901653 BP 1 cellular response to peptide 1 P10644,P22612 209 6.72e-03 181 4 2 0.500 0.011 GO:0043434 BP 1 response to peptide hormone 1 P10644,P22612 209 7.19e-03 2 4 1 0.250 0.500 OMIM:101800 omi 1 Acrodysostosis 1 P10644 209 7.40e-03 190 4 2 0.500 0.011 GO:1901652 BP 1 response to peptide 1 P10644,P22612 209 7.93e-03 885 4 3 0.750 0.003 GO:0019220 BP 1 regulation of phosphate metabolic process 1 P10644,Q8N6U8,P22612 209 8.09e-03 5 4 1 0.250 0.200 GO:0097228 CC 1 sperm principal piece 1 O75969 209 8.09e-03 5 4 1 0.250 0.200 GO:0046007 BP 1 negative regulation of activated T cell proliferation 1 P10644 209 8.25e-03 897 4 3 0.750 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 P10644,Q8N6U8,P22612 209 8.35e-03 202 4 2 0.500 0.010 GO:0019953 BP 1 sexual reproduction 1 O75969,P22612 209 9.02e-03 13 4 1 0.250 0.077 REAC:392517 rea 1 Rap1 signalling 1 P22612 209 9.71e-03 14 4 1 0.250 0.071 REAC:163560 rea 1 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1 P22612 209 9.71e-03 6 4 1 0.250 0.167 GO:0004691 MF 1 cAMP-dependent protein kinase activity 1 P22612 209 9.71e-03 6 4 1 0.250 0.167 GO:0008603 MF 1 cAMP-dependent protein kinase regulator activity 1 P10644 209 9.71e-03 6 4 1 0.250 0.167 GO:0021532 BP 1 neural tube patterning 1 Q8N6U8 209 9.71e-03 6 4 1 0.250 0.167 GO:0004862 MF 1 cAMP-dependent protein kinase inhibitor activity 1 P10644 209 9.71e-03 6 4 1 0.250 0.167 GO:2000480 BP 1 negative regulation of cAMP-dependent protein kinase activity 1 P10644 209 9.98e-03 221 4 2 0.500 0.009 GO:0007596 BP 1 blood coagulation 1 P10644,P22612 209 1.02e-02 223 4 2 0.500 0.009 GO:0007599 BP 1 hemostasis 1 P10644,P22612 209 1.03e-02 224 4 2 0.500 0.009 GO:0050817 BP 1 coagulation 1 P10644,P22612 209 1.07e-02 280 4 2 0.500 0.007 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 P10644,P22612 209 1.07e-02 280 4 2 0.500 0.007 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 P10644,P22612 209 1.07e-02 280 4 2 0.500 0.007 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 P10644,P22612 209 1.08e-02 281 4 2 0.500 0.007 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 P10644,P22612 209 1.09e-02 283 4 2 0.500 0.007 REAC:5654743 rea 1 Signaling by FGFR4 1 P10644,P22612 209 1.09e-02 283 4 2 0.500 0.007 REAC:5654741 rea 1 Signaling by FGFR3 1 P10644,P22612 209 1.11e-02 285 4 2 0.500 0.007 REAC:5654736 rea 1 Signaling by FGFR1 1 P10644,P22612 209 1.11e-02 16 4 1 0.250 0.062 REAC:194223 rea 1 HDL-mediated lipid transport 1 P22612 209 1.15e-02 290 4 2 0.500 0.007 REAC:2424491 rea 1 DAP12 signaling 1 P10644,P22612 209 1.16e-02 292 4 2 0.500 0.007 REAC:186763 rea 1 Downstream signal transduction 1 P10644,P22612 209 1.17e-02 240 4 2 0.500 0.008 GO:0044703 BP 1 multi-organism reproductive process 1 O75969,P22612 209 1.18e-02 294 4 2 0.500 0.007 REAC:2172127 rea 1 DAP12 interactions 1 P10644,P22612 209 1.26e-02 304 4 2 0.500 0.007 REAC:177929 rea 1 Signaling by EGFR 1 P10644,P22612 209 1.29e-02 252 4 2 0.500 0.008 GO:0045860 BP 1 positive regulation of protein kinase activity 1 P10644,P22612 209 1.29e-02 8 4 1 0.250 0.125 GO:0031588 CC 1 nucleotide-activated protein kinase complex 1 P10644 209 1.29e-02 8 4 1 0.250 0.125 GO:0007340 BP 1 acrosome reaction 1 O75969 209 1.29e-02 8 4 1 0.250 0.125 GO:0004690 MF 1 cyclic nucleotide-dependent protein kinase activity 1 P22612 209 1.30e-02 309 4 2 0.500 0.006 REAC:5654738 rea 1 Signaling by FGFR2 1 P10644,P22612 209 1.31e-02 311 4 2 0.500 0.006 REAC:190236 rea 1 Signaling by FGFR 1 P10644,P22612 209 1.32e-02 312 4 2 0.500 0.006 REAC:186797 rea 1 Signaling by PDGF 1 P10644,P22612 209 1.38e-02 260 4 2 0.500 0.008 GO:0071417 BP 1 cellular response to organonitrogen compound 1 P10644,P22612 209 1.39e-02 20 4 1 0.250 0.050 REAC:5621575 rea 1 CD209 (DC-SIGN) signaling 1 P22612 209 1.41e-02 322 4 2 0.500 0.006 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 P10644,P22612 209 1.44e-02 4 4 1 0.250 0.250 OMIM:610489 omi 1 Primary Pigmented Micronodular Adrenocortical Disease 1 P10644 209 1.46e-02 268 4 2 0.500 0.007 GO:0050878 BP 1 regulation of body fluid levels 1 P10644,P22612 209 1.52e-02 273 4 2 0.500 0.007 GO:0033674 BP 1 positive regulation of kinase activity 1 P10644,P22612 209 1.62e-02 10 4 1 0.250 0.100 GO:2000479 BP 1 regulation of cAMP-dependent protein kinase activity 1 P10644 209 1.62e-02 10 4 1 0.250 0.100 GO:0034236 MF 1 protein kinase A catalytic subunit binding 1 P10644 209 1.72e-02 252 4 2 0.500 0.008 MI:hsa-miR-130b* mi 1 MI:hsa-miR-130b* 1 Q8N6U8,P22612 209 1.78e-02 11 4 1 0.250 0.091 GO:0010738 BP 1 regulation of protein kinase A signaling 1 O75969 209 1.82e-02 300 4 2 0.500 0.007 GO:0042060 BP 1 wound healing 1 P10644,P22612 209 1.91e-02 307 4 2 0.500 0.007 GO:0010243 BP 1 response to organonitrogen compound 1 P10644,P22612 209 1.94e-02 12 4 1 0.250 0.083 GO:0045992 BP 1 negative regulation of embryonic development 1 Q8N6U8 209 1.94e-02 12 4 1 0.250 0.083 GO:0045879 BP 1 negative regulation of smoothened signaling pathway 1 Q8N6U8 209 1.96e-02 311 4 2 0.500 0.006 GO:0032870 BP 1 cellular response to hormone stimulus 1 P10644,P22612 209 2.01e-02 315 4 2 0.500 0.006 GO:1901699 BP 1 cellular response to nitrogen compound 1 P10644,P22612 209 2.07e-02 320 4 2 0.500 0.006 GO:0098590 CC 1 plasma membrane region 1 P10644,Q8N6U8 209 2.08e-02 394 4 2 0.500 0.005 REAC:166520 rea 1 Signalling by NGF 1 P10644,P22612 209 2.10e-02 13 4 1 0.250 0.077 GO:0042130 BP 1 negative regulation of T cell proliferation 1 P10644 209 2.14e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 P10644,O75969,Q8N6U8,P22612 209 2.21e-02 32 4 1 0.250 0.031 REAC:70263 rea 1 Gluconeogenesis 1 P22612 209 2.23e-02 4 4 1 0.250 0.250 CORUM:879 cor 1 PRKAC-AKAP5-ADRB1 complex 1 P22612 209 2.25e-02 334 4 2 0.500 0.006 GO:0009611 BP 1 response to wounding 1 P10644,P22612 209 2.28e-02 33 4 1 0.250 0.030 REAC:438064 rea 1 Post NMDA receptor activation events 1 P22612 209 2.42e-02 15 4 1 0.250 0.067 GO:0050672 BP 1 negative regulation of lymphocyte proliferation 1 P10644 209 2.42e-02 15 4 1 0.250 0.067 GO:0032945 BP 1 negative regulation of mononuclear cell proliferation 1 P10644 209 2.42e-02 15 4 1 0.250 0.067 GO:0001772 CC 1 immunological synapse 1 P10644 209 2.43e-02 347 4 2 0.500 0.006 GO:0044702 BP 1 single organism reproductive process 1 O75969,P22612 209 2.50e-02 352 4 2 0.500 0.006 GO:0009725 BP 1 response to hormone 1 P10644,P22612 209 2.55e-02 37 4 1 0.250 0.027 REAC:442755 rea 1 Activation of NMDA receptor upon glutamate binding and postsynaptic events 1 P22612 209 2.59e-02 16 4 1 0.250 0.062 GO:0036126 CC 1 sperm flagellum 1 O75969 209 2.59e-02 16 4 1 0.250 0.062 GO:0046006 BP 1 regulation of activated T cell proliferation 1 P10644 209 2.59e-02 16 4 1 0.250 0.062 GO:0010737 BP 1 protein kinase A signaling 1 O75969 209 2.59e-02 16 4 1 0.250 0.062 GO:0097729 CC 1 9+2 motile cilium 1 O75969 209 2.61e-02 444 4 2 0.500 0.005 REAC:109582 rea 1 Hemostasis 1 P10644,P22612 209 2.75e-02 17 4 1 0.250 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 P10644 209 2.79e-02 5 4 1 0.250 0.200 CORUM:621 cor 1 AKAP250-PKA-PDE4D complex 1 P22612 209 2.79e-02 5 4 1 0.250 0.200 CORUM:518 cor 1 AKAP250-PKA-PDE4D complex 1 P22612 209 2.87e-02 378 4 2 0.500 0.005 GO:1901698 BP 1 response to nitrogen compound 1 P10644,P22612 209 2.98e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 P10644,O75969,Q8N6U8,P22612 209 3.00e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 P10644,O75969,Q8N6U8,P22612 209 3.02e-02 388 4 2 0.500 0.005 GO:0022414 BP 1 reproductive process 1 O75969,P22612 209 3.03e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 P10644,O75969,Q8N6U8,P22612 209 3.04e-02 389 4 2 0.500 0.005 GO:0000003 BP 1 reproduction 1 O75969,P22612 209 3.05e-02 390 4 2 0.500 0.005 GO:0051347 BP 1 positive regulation of transferase activity 1 P10644,P22612 209 3.07e-02 19 4 1 0.250 0.053 GO:0050798 BP 1 activated T cell proliferation 1 P10644 209 3.07e-02 19 4 1 0.250 0.053 GO:0008589 BP 1 regulation of smoothened signaling pathway 1 Q8N6U8 209 3.19e-02 493 4 2 0.500 0.004 REAC:382551 rea 1 Transmembrane transport of small molecules 1 P10644,P22612 209 3.24e-02 402 4 2 0.500 0.005 GO:0045859 BP 1 regulation of protein kinase activity 1 P10644,P22612 209 3.37e-02 49 4 1 0.250 0.020 REAC:174824 rea 1 Lipoprotein metabolism 1 P22612 209 3.45e-02 359 4 2 0.500 0.006 MI:hsa-miR-150 mi 1 MI:hsa-miR-150 1 Q8N6U8,P22612 209 3.55e-02 22 4 1 0.250 0.045 GO:0030291 MF 1 protein serine/threonine kinase inhibitor activity 1 P10644 209 3.70e-02 372 4 2 0.500 0.005 MI:mmu-miR-704 mi 1 MI:mmu-miR-704 1 O75969,Q8N6U8 209 3.85e-02 439 4 2 0.500 0.005 GO:0043549 BP 1 regulation of kinase activity 1 P10644,P22612 209 3.87e-02 24 4 1 0.250 0.042 GO:0046546 BP 1 development of primary male sexual characteristics 1 P22612 209 3.87e-02 24 4 1 0.250 0.042 GO:0008584 BP 1 male gonad development 1 P22612 209 3.87e-02 24 4 1 0.250 0.042 GO:0097223 CC 1 sperm part 1 O75969 209 3.93e-02 444 4 2 0.500 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P10644,P22612 209 3.99e-02 58 4 1 0.250 0.017 REAC:5610780 rea 1 Degradation of GLI1 by the proteasome 1 P22612 209 3.99e-02 58 4 1 0.250 0.017 REAC:5610783 rea 1 Degradation of GLI2 by the proteasome 1 P22612 209 4.04e-02 25 4 1 0.250 0.040 GO:0050868 BP 1 negative regulation of T cell activation 1 P10644 209 4.05e-02 59 4 1 0.250 0.017 REAC:5610785 rea 1 GLI3 is processed to GLI3R by the proteasome 1 P22612 209 4.20e-02 26 4 1 0.250 0.038 GO:0046661 BP 1 male sex differentiation 1 P22612 209 4.20e-02 459 4 2 0.500 0.004 GO:0001934 BP 1 positive regulation of protein phosphorylation 1 P10644,P22612 209 4.24e-02 399 4 2 0.500 0.005 MI:hsa-miR-508-3p mi 1 MI:hsa-miR-508-3p 1 O75969,Q8N6U8 209 4.30e-02 577 4 2 0.500 0.003 REAC:372790 rea 1 Signaling by GPCR 1 P10644,P22612 209 4.31e-02 402 4 2 0.500 0.005 MI:hsa-miR-187 mi 1 MI:hsa-miR-187 1 O75969,P22612 209 4.35e-02 1575 4 3 0.750 0.002 REAC:162582 rea 1 Signal Transduction 1 P10644,Q8N6U8,P22612 209 4.36e-02 27 4 1 0.250 0.037 GO:0009953 BP 1 dorsal/ventral pattern formation 1 Q8N6U8 209 4.36e-02 27 4 1 0.250 0.037 GO:1903038 BP 1 negative regulation of leukocyte cell-cell adhesion 1 P10644 209 4.65e-02 484 4 2 0.500 0.004 GO:0042327 BP 1 positive regulation of phosphorylation 1 P10644,P22612 209 4.68e-02 29 4 1 0.250 0.034 GO:0060170 CC 1 ciliary membrane 1 Q8N6U8 209 4.75e-02 1635 4 3 0.750 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 P10644,Q8N6U8,P22612 209 4.78e-02 424 4 2 0.500 0.005 MI:hsa-miR-138 mi 1 MI:hsa-miR-138 1 Q8N6U8,P22612 209 4.84e-02 30 4 1 0.250 0.033 GO:0030819 BP 1 positive regulation of cAMP biosynthetic process 1 Q8N6U8 209 4.84e-02 427 4 2 0.500 0.005 MI:hsa-miR-140-5p mi 1 MI:hsa-miR-140-5p 1 O75969,Q8N6U8 209 5.00e-02 31 4 1 0.250 0.032 GO:0030816 BP 1 positive regulation of cAMP metabolic process 1 Q8N6U8 209 5.00e-02 14 4 1 0.250 0.071 OMIM:231200 omi 1 Platelet-Type Bleeding Disorders 1 P22612 209 5.00e-02 37 4 2 0.500 0.054 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q8N6U8,P22612 209 5.00e-02 9 4 1 0.250 0.111 CORUM:520 cor 1 KCNQ1 macromolecular complex 1 P22612 209 5.00e-02 101 4 3 0.750 0.030 HP:0000858 hp 1 Menstrual irregularities 1 P10644,Q8N6U8,P22612 209 5.00e-02 434 4 2 0.500 0.005 MI:hsa-miR-129-3p mi 1 MI:hsa-miR-129-3p 1 O75969,Q8N6U8 209 5.00e-02 2213 4 4 1.000 0.002 TF:M07065_1 tf 1 Factor: STAT3; motif: TTCYGGGAAN; match class: 1 1 P10644,O75969,Q8N6U8,P22612 210 3.23e-03 2 2 1 0.500 0.500 GO:0030627 MF 1 pre-mRNA 5'-splice site binding 1 Q86UA1 210 6.46e-03 4 2 1 0.500 0.250 GO:0006451 BP 1 translational readthrough 1 Q9NX07 210 6.46e-03 4 2 1 0.500 0.250 GO:0001514 BP 1 selenocysteine incorporation 1 Q9NX07 210 9.69e-03 6 2 1 0.500 0.167 GO:0000395 BP 1 mRNA 5'-splice site recognition 1 Q86UA1 210 1.13e-02 7 2 1 0.500 0.143 GO:0000243 CC 1 commitment complex 1 Q86UA1 210 2.06e-02 1550 2 2 1.000 0.001 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 Q9NX07,Q86UA1 210 2.42e-02 15 2 1 0.500 0.067 GO:0071004 CC 1 U2-type prespliceosome 1 Q86UA1 210 2.58e-02 16 2 1 0.500 0.062 GO:0045292 BP 1 mRNA cis splicing, via spliceosome 1 Q86UA1 210 2.74e-02 17 2 1 0.500 0.059 GO:0005685 CC 1 U1 snRNP 1 Q86UA1 210 2.90e-02 18 2 1 0.500 0.056 GO:0036002 MF 1 pre-mRNA binding 1 Q86UA1 210 3.03e-02 7 2 1 0.500 0.143 TF:M06312_0 tf 1 Factor: ZNF79; motif: NCGTTCGAAATC; match class: 0 1 Q86UA1 210 3.39e-02 21 2 1 0.500 0.048 GO:0071010 CC 1 prespliceosome 1 Q86UA1 210 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 Q9NX07,Q86UA1 210 3.55e-02 22 2 1 0.500 0.045 GO:0006376 BP 1 mRNA splice site selection 1 Q86UA1 210 4.75e-02 11 2 1 0.500 0.091 TF:M06933_0 tf 1 Factor: Smad6; motif: TTGSCCGCCWTA; match class: 0 1 Q9NX07 210 5.00e-02 543 2 2 1.000 0.004 TF:M01651_1 tf 1 Factor: P53; motif: RGRCATGYCYRGRCATGYYY; match class: 1 1 Q9NX07,Q86UA1 210 5.00e-02 398 2 2 1.000 0.005 MI:hsa-miR-938 mi 1 MI:hsa-miR-938 1 Q9NX07,Q86UA1 210 5.00e-02 31 2 1 0.500 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 Q86UA1 211 3.84e-06 17 2 2 1.000 0.118 GO:0001580 BP 1 detection of chemical stimulus involved in sensory perception of bitter taste 1 P09228,P01037 211 3.84e-06 17 2 2 1.000 0.118 GO:0050913 BP 1 sensory perception of bitter taste 1 P09228,P01037 211 4.32e-06 18 2 2 1.000 0.111 GO:0050912 BP 1 detection of chemical stimulus involved in sensory perception of taste 1 P09228,P01037 211 5.93e-06 21 2 2 1.000 0.095 GO:0050909 BP 1 sensory perception of taste 1 P09228,P01037 211 1.68e-05 35 2 2 1.000 0.057 GO:0004869 MF 1 cysteine-type endopeptidase inhibitor activity 1 P09228,P01037 211 1.99e-05 38 2 2 1.000 0.053 GO:0050907 BP 1 detection of chemical stimulus involved in sensory perception 1 P09228,P01037 211 3.89e-05 53 2 2 1.000 0.038 GO:0050906 BP 1 detection of stimulus involved in sensory perception 1 P09228,P01037 211 4.35e-05 56 2 2 1.000 0.036 GO:2000117 BP 1 negative regulation of cysteine-type endopeptidase activity 1 P09228,P01037 211 4.35e-05 56 2 2 1.000 0.036 GO:0009593 BP 1 detection of chemical stimulus 1 P09228,P01037 211 7.02e-05 71 2 2 1.000 0.028 GO:0010951 BP 1 negative regulation of endopeptidase activity 1 P09228,P01037 211 7.84e-05 75 2 2 1.000 0.027 GO:0007606 BP 1 sensory perception of chemical stimulus 1 P09228,P01037 211 8.05e-05 76 2 2 1.000 0.026 GO:0010466 BP 1 negative regulation of peptidase activity 1 P09228,P01037 211 8.27e-05 77 2 2 1.000 0.026 GO:0002020 MF 1 protease binding 1 P09228,P01037 211 1.03e-04 86 2 2 1.000 0.023 GO:0004866 MF 1 endopeptidase inhibitor activity 1 P09228,P01037 211 1.11e-04 89 2 2 1.000 0.022 GO:0030414 MF 1 peptidase inhibitor activity 1 P09228,P01037 211 1.16e-04 91 2 2 1.000 0.022 GO:0061135 MF 1 endopeptidase regulator activity 1 P09228,P01037 211 1.88e-04 116 2 2 1.000 0.017 GO:0061134 MF 1 peptidase regulator activity 1 P09228,P01037 211 1.98e-04 119 2 2 1.000 0.017 GO:0045861 BP 1 negative regulation of proteolysis 1 P09228,P01037 211 2.71e-04 139 2 2 1.000 0.014 GO:2000116 BP 1 regulation of cysteine-type endopeptidase activity 1 P09228,P01037 211 2.79e-04 141 2 2 1.000 0.014 GO:0051606 BP 1 detection of stimulus 1 P09228,P01037 211 3.87e-04 166 2 2 1.000 0.012 GO:0052548 BP 1 regulation of endopeptidase activity 1 P09228,P01037 211 4.06e-04 170 2 2 1.000 0.012 GO:0051346 BP 1 negative regulation of hydrolase activity 1 P09228,P01037 211 4.30e-04 175 2 2 1.000 0.011 GO:0052547 BP 1 regulation of peptidase activity 1 P09228,P01037 211 6.56e-04 216 2 2 1.000 0.009 GO:0007600 BP 1 sensory perception 1 P09228,P01037 211 6.62e-04 217 2 2 1.000 0.009 GO:0004857 MF 1 enzyme inhibitor activity 1 P09228,P01037 211 1.50e-03 326 2 2 1.000 0.006 GO:0050877 BP 1 neurological system process 1 P09228,P01037 211 2.45e-03 417 2 2 1.000 0.005 GO:0030162 BP 1 regulation of proteolysis 1 P09228,P01037 211 2.47e-03 419 2 2 1.000 0.005 GO:0043086 BP 1 negative regulation of catalytic activity 1 P09228,P01037 211 3.61e-03 506 2 2 1.000 0.004 GO:0051336 BP 1 regulation of hydrolase activity 1 P09228,P01037 211 4.58e-03 570 2 2 1.000 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 P09228,P01037 211 4.61e-03 572 2 2 1.000 0.003 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 P09228,P01037 211 4.78e-03 582 2 2 1.000 0.003 GO:0030234 MF 1 enzyme regulator activity 1 P09228,P01037 211 5.20e-03 607 2 2 1.000 0.003 GO:0051248 BP 1 negative regulation of protein metabolic process 1 P09228,P01037 211 6.29e-03 668 2 2 1.000 0.003 GO:0005615 CC 1 extracellular space 1 P09228,P01037 211 6.77e-03 693 2 2 1.000 0.003 GO:0003008 BP 1 system process 1 P09228,P01037 211 7.16e-03 914 2 2 1.000 0.002 HPA:040020_10 hpa 1 soft tissue 2; chondrocytes[Supportive,Not detected] 1 P09228,P01037 211 9.67e-03 828 2 2 1.000 0.002 GO:0098772 MF 1 molecular function regulator 1 P09228,P01037 211 1.03e-02 272 2 2 1.000 0.007 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 P09228,P01037 211 1.06e-02 276 2 2 1.000 0.007 MI:hsa-miR-96* mi 1 MI:hsa-miR-96* 1 P09228,P01037 211 1.24e-02 937 2 2 1.000 0.002 GO:0006508 BP 1 proteolysis 1 P09228,P01037 211 1.35e-02 312 2 2 1.000 0.006 MI:hsa-miR-196a* mi 1 MI:hsa-miR-196a* 1 P09228,P01037 211 1.39e-02 317 2 2 1.000 0.006 MI:hsa-miR-221* mi 1 MI:hsa-miR-221* 1 P09228,P01037 211 1.55e-02 334 2 2 1.000 0.006 MI:hsa-miR-942 mi 1 MI:hsa-miR-942 1 P09228,P01037 211 1.62e-02 1071 2 2 1.000 0.002 GO:0050790 BP 1 regulation of catalytic activity 1 P09228,P01037 211 1.74e-02 354 2 2 1.000 0.006 MI:hsa-miR-93* mi 1 MI:hsa-miR-93* 1 P09228,P01037 211 1.83e-02 363 2 2 1.000 0.006 MI:hsa-miR-150* mi 1 MI:hsa-miR-150* 1 P09228,P01037 211 2.01e-02 381 2 2 1.000 0.005 MI:hsa-miR-511 mi 1 MI:hsa-miR-511 1 P09228,P01037 211 2.10e-02 389 2 2 1.000 0.005 MI:hsa-miR-92a-2* mi 1 MI:hsa-miR-92a-2* 1 P09228,P01037 211 2.13e-02 392 2 2 1.000 0.005 MI:hsa-miR-370 mi 1 MI:hsa-miR-370 1 P09228,P01037 211 2.14e-02 1230 2 2 1.000 0.002 GO:0019899 MF 1 enzyme binding 1 P09228,P01037 211 2.30e-02 407 2 2 1.000 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 P09228,P01037 211 2.39e-02 415 2 2 1.000 0.005 MI:hsa-miR-491-5p mi 1 MI:hsa-miR-491-5p 1 P09228,P01037 211 2.42e-02 1310 2 2 1.000 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 P09228,P01037 211 2.45e-02 1317 2 2 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 P09228,P01037 211 2.54e-02 1342 2 2 1.000 0.001 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 P09228,P01037 211 2.64e-02 1756 2 2 1.000 0.001 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P09228,P01037 211 2.72e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 P09228,P01037 211 2.86e-02 1424 2 2 1.000 0.001 GO:0009892 BP 1 negative regulation of metabolic process 1 P09228,P01037 211 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 P09228,P01037 211 2.92e-02 459 2 2 1.000 0.004 MI:hsa-miR-608 mi 1 MI:hsa-miR-608 1 P09228,P01037 211 2.93e-02 1442 2 2 1.000 0.001 GO:0051246 BP 1 regulation of protein metabolic process 1 P09228,P01037 211 3.03e-02 467 2 2 1.000 0.004 MI:hsa-miR-891a mi 1 MI:hsa-miR-891a 1 P09228,P01037 211 3.04e-02 468 2 2 1.000 0.004 MI:hsa-miR-802 mi 1 MI:hsa-miR-802 1 P09228,P01037 211 3.11e-02 473 2 2 1.000 0.004 MI:hsa-miR-503 mi 1 MI:hsa-miR-503 1 P09228,P01037 211 3.48e-02 501 2 2 1.000 0.004 MI:mmu-miR-465a-3p mi 1 MI:mmu-miR-465a-3p 1 P09228,P01037 211 3.68e-02 2072 2 2 1.000 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 P09228,P01037 211 3.96e-02 534 2 2 1.000 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 P09228,P01037 211 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P09228,P01037 211 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P09228,P01037 211 5.00e-02 64 2 2 1.000 0.031 KEGG:04970 keg 1 Salivary secretion 1 P09228,P01037 211 5.00e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 P09228,P01037 211 5.00e-02 600 2 2 1.000 0.003 MI:mmu-miR-466d-5p mi 1 MI:mmu-miR-466d-5p 1 P09228,P01037 211 5.00e-02 75 2 2 1.000 0.027 TF:M05310_1 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 1 1 P09228,P01037 212 3.91e-08 28 3 3 1.000 0.107 GO:0034080 BP 1 CENP-A containing nucleosome assembly 1 O43482,Q6P0N0,Q9NYP9 212 3.91e-08 28 3 3 1.000 0.107 GO:0061641 BP 1 CENP-A containing chromatin organization 1 O43482,Q6P0N0,Q9NYP9 212 4.84e-08 30 3 3 1.000 0.100 GO:0031055 BP 1 chromatin remodeling at centromere 1 O43482,Q6P0N0,Q9NYP9 212 9.27e-08 37 3 3 1.000 0.081 GO:0006336 BP 1 DNA replication-independent nucleosome assembly 1 O43482,Q6P0N0,Q9NYP9 212 1.01e-07 38 3 3 1.000 0.079 GO:0034724 BP 1 DNA replication-independent nucleosome organization 1 O43482,Q6P0N0,Q9NYP9 212 1.01e-07 38 3 3 1.000 0.079 GO:0034508 BP 1 centromere complex assembly 1 O43482,Q6P0N0,Q9NYP9 212 1.18e-07 40 3 3 1.000 0.075 GO:0043486 BP 1 histone exchange 1 O43482,Q6P0N0,Q9NYP9 212 4.08e-07 60 3 3 1.000 0.050 GO:0043044 BP 1 ATP-dependent chromatin remodeling 1 O43482,Q6P0N0,Q9NYP9 212 6.53e-07 70 3 3 1.000 0.043 GO:0006334 BP 1 nucleosome assembly 1 O43482,Q6P0N0,Q9NYP9 212 1.18e-06 85 3 3 1.000 0.035 GO:0031497 BP 1 chromatin assembly 1 O43482,Q6P0N0,Q9NYP9 212 1.55e-06 93 3 3 1.000 0.032 GO:0034728 BP 1 nucleosome organization 1 O43482,Q6P0N0,Q9NYP9 212 2.05e-06 102 3 3 1.000 0.029 GO:0006333 BP 1 chromatin assembly or disassembly 1 O43482,Q6P0N0,Q9NYP9 212 2.57e-06 110 3 3 1.000 0.027 GO:0006323 BP 1 DNA packaging 1 O43482,Q6P0N0,Q9NYP9 212 2.94e-06 115 3 3 1.000 0.026 GO:0006338 BP 1 chromatin remodeling 1 O43482,Q6P0N0,Q9NYP9 212 3.43e-06 121 3 3 1.000 0.025 GO:0000775 CC 1 chromosome, centromeric region 1 O43482,Q6P0N0,Q9NYP9 212 4.68e-06 134 3 3 1.000 0.022 GO:0065004 BP 1 protein-DNA complex assembly 1 O43482,Q6P0N0,Q9NYP9 212 6.98e-06 153 3 3 1.000 0.020 GO:0071103 BP 1 DNA conformation change 1 O43482,Q6P0N0,Q9NYP9 212 7.55e-06 157 3 3 1.000 0.019 GO:0071824 BP 1 protein-DNA complex subunit organization 1 O43482,Q6P0N0,Q9NYP9 212 2.12e-05 42 3 3 1.000 0.071 REAC:774815 rea 1 Nucleosome assembly 1 O43482,Q6P0N0,Q9NYP9 212 2.12e-05 42 3 3 1.000 0.071 REAC:606279 rea 1 Deposition of new CENPA-containing nucleosomes at the centromere 1 O43482,Q6P0N0,Q9NYP9 212 2.39e-05 230 3 3 1.000 0.013 GO:0098687 CC 1 chromosomal region 1 O43482,Q6P0N0,Q9NYP9 212 1.40e-04 78 3 3 1.000 0.038 REAC:73886 rea 1 Chromosome Maintenance 1 O43482,Q6P0N0,Q9NYP9 212 1.75e-04 446 3 3 1.000 0.007 GO:0051276 BP 1 chromosome organization 1 O43482,Q6P0N0,Q9NYP9 212 1.79e-04 449 3 3 1.000 0.007 GO:0006325 BP 1 chromatin organization 1 O43482,Q6P0N0,Q9NYP9 212 3.57e-04 565 3 3 1.000 0.005 GO:0044427 CC 1 chromosomal part 1 O43482,Q6P0N0,Q9NYP9 212 4.47e-04 609 3 3 1.000 0.005 GO:0005694 CC 1 chromosome 1 O43482,Q6P0N0,Q9NYP9 212 6.47e-04 689 3 3 1.000 0.004 GO:0034622 BP 1 cellular macromolecular complex assembly 1 O43482,Q6P0N0,Q9NYP9 212 2.73e-03 1113 3 3 1.000 0.003 GO:0065003 BP 1 macromolecular complex assembly 1 O43482,Q6P0N0,Q9NYP9 212 4.67e-03 263 3 2 0.667 0.008 GO:0007059 BP 1 chromosome segregation 1 O43482,Q9NYP9 212 4.68e-03 449 3 2 0.667 0.004 MI:hsa-miR-505 mi 1 MI:hsa-miR-505 1 O43482,Q6P0N0 212 5.82e-03 294 3 2 0.667 0.007 GO:0000785 CC 1 chromatin 1 O43482,Q9NYP9 212 6.34e-03 8 3 1 0.333 0.125 GO:0000778 CC 1 condensed nuclear chromosome kinetochore 1 Q6P0N0 212 8.34e-03 1614 3 3 1.000 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 O43482,Q6P0N0,Q9NYP9 212 9.51e-03 12 3 1 0.333 0.083 GO:0000780 CC 1 condensed nuclear chromosome, centromeric region 1 Q6P0N0 212 9.85e-03 1706 3 3 1.000 0.002 GO:0022607 BP 1 cellular component assembly 1 O43482,Q6P0N0,Q9NYP9 212 1.43e-02 1932 3 3 1.000 0.002 GO:0044085 BP 1 cellular component biogenesis 1 O43482,Q6P0N0,Q9NYP9 212 1.49e-02 1960 3 3 1.000 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 O43482,Q6P0N0,Q9NYP9 212 1.49e-02 1960 3 3 1.000 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 O43482,Q6P0N0,Q9NYP9 212 1.82e-02 23 3 1 0.333 0.043 GO:0000777 CC 1 condensed chromosome kinetochore 1 Q6P0N0 212 2.30e-02 2262 3 3 1.000 0.001 GO:0006996 BP 1 organelle organization 1 O43482,Q6P0N0,Q9NYP9 212 2.45e-02 31 3 1 0.333 0.032 GO:0000779 CC 1 condensed chromosome, centromeric region 1 Q6P0N0 212 2.69e-02 34 3 1 0.333 0.029 GO:0015030 CC 1 Cajal body 1 O43482 212 3.21e-02 2529 3 3 1.000 0.001 GO:0005654 CC 1 nucleoplasm 1 O43482,Q6P0N0,Q9NYP9 212 4.34e-02 55 3 1 0.333 0.018 GO:0000794 CC 1 condensed nuclear chromosome 1 Q6P0N0 212 4.49e-02 1737 3 3 1.000 0.002 TF:M01011_1 tf 1 Factor: HNF1; motif: NNNNGNTAAWNATTAACYNNN; match class: 1 1 O43482,Q6P0N0,Q9NYP9 212 5.00e-02 547 3 3 1.000 0.005 REAC:1640170 rea 1 Cell Cycle 1 O43482,Q6P0N0,Q9NYP9 212 5.00e-02 2931 3 3 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 O43482,Q6P0N0,Q9NYP9 212 5.00e-02 12 3 1 0.333 0.083 TF:M00953_1 tf 1 Factor: AR; motif: NNNGNRRGNACANNGTGTTCTNNNNNN; match class: 1 1 Q6P0N0 213 1.47e-02 2647 3 3 1.000 0.001 HPA:001010_03 hpa 1 adrenal gland; glandular cells[Uncertain,High] 1 Q96S38,A8MVW0,Q8IWF6 213 1.50e-02 3 3 1 0.333 0.333 GO:2000049 BP 1 positive regulation of cell-cell adhesion mediated by cadherin 1 Q8IWF6 213 2.55e-02 1028 3 2 0.667 0.002 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 A8MVW0,Q8IWF6 213 3.00e-02 6 3 1 0.333 0.167 GO:2000047 BP 1 regulation of cell-cell adhesion mediated by cadherin 1 Q8IWF6 213 3.73e-02 1254 3 2 0.667 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 Q96S38,Q8IWF6 213 5.00e-02 111 3 2 0.667 0.018 TF:M04197_0 tf 1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 0 1 Q96S38,A8MVW0 213 5.00e-02 10 3 1 0.333 0.100 GO:0044331 BP 1 cell-cell adhesion mediated by cadherin 1 Q8IWF6 214 3.38e-03 705 2 2 1.000 0.003 TF:M07052_1 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 1 O60870,Q96QC0 214 6.60e-03 985 2 2 1.000 0.002 TF:M02102_1 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 1 O60870,Q96QC0 214 6.75e-03 39 2 1 0.500 0.026 TF:M00707_1 tf 1 Factor: TFIIA; motif: TMTRWRAGGRSS; match class: 1 1 Q96QC0 214 8.99e-03 52 2 1 0.500 0.019 TF:M06112_0 tf 1 Factor: ZNF682; motif: NGGGAAGTCKGA; match class: 0 1 O60870 214 8.99e-03 52 2 1 0.500 0.019 TF:M07123_1 tf 1 Factor: rfx5; motif: YNSCMTRGCAACAGN; match class: 1 1 Q96QC0 214 9.01e-03 1025 2 2 1.000 0.002 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 O60870,Q96QC0 214 9.16e-03 53 2 1 0.500 0.019 TF:M01241_1 tf 1 Factor: BEN; motif: CWGCGAYA; match class: 1 1 O60870 214 1.18e-02 1175 2 2 1.000 0.002 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 O60870,Q96QC0 214 1.28e-02 74 2 1 0.500 0.014 TF:M00215_0 tf 1 Factor: SRF; motif: DCCWTATATGGNCWN; match class: 0 1 O60870 214 1.35e-02 78 2 1 0.500 0.013 TF:M06741_0 tf 1 Factor: ZNF70; motif: NGGWCAAAAAGM; match class: 0 1 O60870 214 1.43e-02 83 2 1 0.500 0.012 TF:M04473_0 tf 1 Factor: NR2F1; motif: RRGGTCAARAGGTCAN; match class: 0 1 Q96QC0 214 1.48e-02 1474 2 2 1.000 0.001 TF:M01211_0 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 0 1 O60870,Q96QC0 214 1.95e-02 1693 2 2 1.000 0.001 TF:M01826_0 tf 1 Factor: PITX1; motif: GMMACTAATCY; match class: 0 1 O60870,Q96QC0 214 1.95e-02 1508 2 2 1.000 0.001 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 O60870,Q96QC0 214 2.02e-02 117 2 1 0.500 0.009 TF:M06173_0 tf 1 Factor: ZNF85; motif: KGGCGGAAGM; match class: 0 1 Q96QC0 214 2.14e-02 1578 2 2 1.000 0.001 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 O60870,Q96QC0 214 2.22e-02 129 2 1 0.500 0.008 TF:M04107_0 tf 1 Factor: RUNX2; motif: WRACCGCANWAACCGCAN; match class: 0 1 Q96QC0 214 2.24e-02 130 2 1 0.500 0.008 TF:M06017_0 tf 1 Factor: ZNF586; motif: CCTGCMYGGTGM; match class: 0 1 O60870 214 2.44e-02 1894 2 2 1.000 0.001 TF:M04385_0 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 0 1 O60870,Q96QC0 214 2.56e-02 1939 2 2 1.000 0.001 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 O60870,Q96QC0 214 2.58e-02 150 2 1 0.500 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 O60870 214 2.75e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 O60870 214 2.77e-02 2018 2 2 1.000 0.001 TF:M00658_1 tf 1 Factor: PU.1; motif: WGAGGAAG; match class: 1 1 O60870,Q96QC0 214 2.79e-02 1804 2 2 1.000 0.001 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 O60870,Q96QC0 214 2.89e-02 2062 2 2 1.000 0.001 TF:M07052_0 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 0 1 O60870,Q96QC0 214 2.91e-02 2068 2 2 1.000 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 O60870,Q96QC0 214 3.03e-02 2110 2 2 1.000 0.001 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 O60870,Q96QC0 214 3.03e-02 2111 2 2 1.000 0.001 TF:M04073_1 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1 O60870,Q96QC0 214 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 O60870,Q96QC0 214 3.11e-02 2137 2 2 1.000 0.001 TF:M00789_1 tf 1 Factor: GATA; motif: WGATARN; match class: 1 1 O60870,Q96QC0 214 3.11e-02 2137 2 2 1.000 0.001 TF:M03216_1 tf 1 Factor: GATA-6; motif: AGATAAN; match class: 1 1 O60870,Q96QC0 214 3.15e-02 2153 2 2 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 O60870,Q96QC0 214 3.15e-02 2153 2 2 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 O60870,Q96QC0 214 3.28e-02 191 2 1 0.500 0.005 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 O60870 214 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 O60870,Q96QC0 214 3.46e-02 2257 2 2 1.000 0.001 TF:M04075_1 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 1 1 O60870,Q96QC0 214 3.50e-02 2270 2 2 1.000 0.001 TF:M01739_0 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 0 1 O60870,Q96QC0 214 3.52e-02 205 2 1 0.500 0.005 TF:M01299_0 tf 1 Factor: MECP2; motif: CCGGNNTTWA; match class: 0 1 O60870 214 3.73e-02 217 2 1 0.500 0.005 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 O60870 214 3.93e-02 2405 2 2 1.000 0.001 TF:M04071_0 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 0 1 O60870,Q96QC0 214 4.17e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 O60870,Q96QC0 214 4.22e-02 2492 2 2 1.000 0.001 TF:M05347_0 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 0 1 O60870,Q96QC0 214 4.24e-02 2497 2 2 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 O60870,Q96QC0 214 4.27e-02 249 2 1 0.500 0.004 TF:M04110_0 tf 1 Factor: RUNX3; motif: NRACCGCANWAACCRCAN; match class: 0 1 Q96QC0 214 4.30e-02 251 2 1 0.500 0.004 TF:M01304_0 tf 1 Factor: SRF; motif: NNCCAWAWAAGGV; match class: 0 1 O60870 214 4.32e-02 252 2 1 0.500 0.004 TF:M04613_0 tf 1 Factor: HLTF; motif: AGSCARAAAGYRGSTGS; match class: 0 1 Q96QC0 214 4.34e-02 253 2 1 0.500 0.004 TF:M05498_0 tf 1 Factor: DRRS; motif: NGTAGTCAGC; match class: 0 1 Q96QC0 214 4.34e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 O60870,Q96QC0 214 4.41e-02 257 2 1 0.500 0.004 TF:M04203_1 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 1 1 O60870 214 4.51e-02 2576 2 2 1.000 0.001 TF:M04616_0 tf 1 Factor: islet1; motif: NGNTAATG; match class: 0 1 O60870,Q96QC0 214 4.54e-02 265 2 1 0.500 0.004 TF:M01735_1 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 1 1 O60870 214 4.68e-02 2622 2 2 1.000 0.001 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 O60870,Q96QC0 214 4.70e-02 274 2 1 0.500 0.004 TF:M00622_1 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 1 1 Q96QC0 214 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 O60870,Q96QC0 214 4.77e-02 2647 2 2 1.000 0.001 TF:M04343_0 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 0 1 O60870,Q96QC0 214 4.81e-02 2659 2 2 1.000 0.001 TF:M04440_0 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 0 1 O60870,Q96QC0 214 4.87e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 O60870,Q96QC0 214 4.98e-02 2706 2 2 1.000 0.001 TF:M01856_0 tf 1 Factor: AML3; motif: AACCACAN; match class: 0 1 O60870,Q96QC0 214 4.98e-02 2706 2 2 1.000 0.001 TF:M01759_0 tf 1 Factor: AML2; motif: AACCRCAA; match class: 0 1 O60870,Q96QC0 214 5.00e-02 292 2 1 0.500 0.003 TF:M00687_1 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 1 Q96QC0 214 5.00e-02 7 2 1 0.500 0.143 GO:0072357 CC 1 PTW/PP1 phosphatase complex 1 Q96QC0 214 5.00e-02 452 2 2 1.000 0.004 MI:hsa-miR-376a mi 1 MI:hsa-miR-376a 1 O60870,Q96QC0 214 5.00e-02 2 2 1 0.500 0.500 CORUM:180 cor 1 PNUTS-PP1 complex 1 Q96QC0 215 4.86e-05 8 7 2 0.286 0.250 GO:0010842 BP 1 retina layer formation 1 Q58EX2,Q7Z5N4 215 7.81e-05 10 7 2 0.286 0.200 GO:0060042 BP 1 retina morphogenesis in camera-type eye 1 Q58EX2,Q7Z5N4 215 1.58e-04 14 7 2 0.286 0.143 GO:0003407 BP 1 neural retina development 1 Q58EX2,Q7Z5N4 215 6.06e-04 27 7 2 0.286 0.074 GO:0048593 BP 1 camera-type eye morphogenesis 1 Q58EX2,Q7Z5N4 215 6.87e-04 354 7 3 0.429 0.008 TF:M01298_0 tf 1 Factor: MECP2; motif: CCGGSNNNANNAWWT; match class: 0 1 Q58EX2,P08183,Q9ULI3 215 7.51e-04 30 7 2 0.286 0.067 GO:0060041 BP 1 retina development in camera-type eye 1 Q58EX2,Q7Z5N4 215 9.67e-04 34 7 2 0.286 0.059 GO:0007156 BP 1 homophilic cell adhesion via plasma membrane adhesion molecules 1 Q58EX2,Q7Z5N4 215 1.41e-03 41 7 2 0.286 0.049 GO:0048592 BP 1 eye morphogenesis 1 Q58EX2,Q7Z5N4 215 2.73e-03 57 7 2 0.286 0.035 GO:0007416 BP 1 synapse assembly 1 Q58EX2,Q7Z5N4 215 2.83e-03 58 7 2 0.286 0.034 GO:0090596 BP 1 sensory organ morphogenesis 1 Q58EX2,Q7Z5N4 215 3.03e-03 60 7 2 0.286 0.033 GO:0043010 BP 1 camera-type eye development 1 Q58EX2,Q7Z5N4 215 3.35e-03 1 7 1 0.143 1.000 GO:0019863 MF 1 IgE binding 1 P17931 215 3.35e-03 1 7 1 0.143 1.000 GO:2000520 BP 1 regulation of immunological synapse formation 1 P17931 215 3.35e-03 1 7 1 0.143 1.000 GO:2000521 BP 1 negative regulation of immunological synapse formation 1 P17931 215 3.35e-03 1 7 1 0.143 1.000 GO:2001189 BP 1 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1 P17931 215 3.65e-03 172 7 2 0.286 0.012 TF:M04314_1 tf 1 Factor: EMX2; motif: NNTAATTANN; match class: 1 1 P08183,Q9ULI3 215 4.85e-03 76 7 2 0.286 0.026 GO:0098742 BP 1 cell-cell adhesion via plasma-membrane adhesion molecules 1 Q58EX2,Q7Z5N4 215 5.54e-03 213 7 2 0.286 0.009 TF:M04417_1 tf 1 Factor: NOTO; motif: NYTAATTANN; match class: 1 1 P08183,Q9ULI3 215 6.64e-03 389 7 3 0.429 0.008 GO:0098609 BP 1 cell-cell adhesion 1 Q58EX2,P17931,Q7Z5N4 215 6.69e-03 2 7 1 0.143 0.500 GO:0090555 MF 1 phosphatidylethanolamine-translocating ATPase activity 1 P08183 215 6.69e-03 2 7 1 0.143 0.500 GO:0046623 MF 1 sphingolipid-translocating ATPase activity 1 P08183 215 6.69e-03 2 7 1 0.143 0.500 GO:0070444 BP 1 oligodendrocyte progenitor proliferation 1 P23471 215 6.69e-03 2 7 1 0.143 0.500 GO:0099040 BP 1 ceramide translocation 1 P08183 215 6.69e-03 2 7 1 0.143 0.500 GO:0070445 BP 1 regulation of oligodendrocyte progenitor proliferation 1 P23471 215 6.69e-03 2 7 1 0.143 0.500 GO:0005608 CC 1 laminin-3 complex 1 P25391 215 6.69e-03 2 7 1 0.143 0.500 GO:0099038 MF 1 ceramide-translocating ATPase activity 1 P08183 215 6.69e-03 2 7 1 0.143 0.500 GO:1904121 MF 1 phosphatidylethanolamine transporter activity 1 P08183 215 6.69e-03 2 7 1 0.143 0.500 GO:0001771 BP 1 immunological synapse formation 1 P17931 215 6.69e-03 2 7 1 0.143 0.500 GO:0099039 BP 1 sphingolipid translocation 1 P08183 215 6.76e-03 236 7 2 0.286 0.008 TF:M04427_1 tf 1 Factor: PHOX2B; motif: TAATYYAATTA; match class: 1 1 P08183,P23471 215 6.79e-03 90 7 2 0.286 0.022 GO:0050808 BP 1 synapse organization 1 Q58EX2,Q7Z5N4 215 6.95e-03 91 7 2 0.286 0.022 GO:0001654 BP 1 eye development 1 Q58EX2,Q7Z5N4 215 7.04e-03 241 7 2 0.286 0.008 TF:M04308_1 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 1 1 P08183,P23471 215 7.62e-03 251 7 2 0.286 0.008 TF:M03899_1 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 1 1 P25391,Q9ULI3 215 7.68e-03 14 7 1 0.143 0.071 TF:M06949_1 tf 1 Factor: EVX2; motif: WAATTAAATT; match class: 1 1 P23471 215 8.04e-03 258 7 2 0.286 0.008 TF:M06275_0 tf 1 Factor: ZNF284; motif: NGGGGGTGGTGM; match class: 0 1 Q58EX2,Q7Z5N4 215 8.46e-03 265 7 2 0.286 0.008 TF:M04426_1 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 1 1 P08183,P23471 215 8.59e-03 854 7 3 0.429 0.004 TF:M07095_0 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 0 1 P08183,P17931,Q9ULI3 215 1.00e-02 3 7 1 0.143 0.333 GO:0008559 MF 1 xenobiotic-transporting ATPase activity 1 P08183 215 1.00e-02 3 7 1 0.143 0.333 GO:2001188 BP 1 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1 P17931 215 1.00e-02 3 7 1 0.143 0.333 GO:0005606 CC 1 laminin-1 complex 1 P25391 215 1.00e-02 3 7 1 0.143 0.333 GO:0048245 BP 1 eosinophil chemotaxis 1 P17931 215 1.04e-02 3035 7 5 0.714 0.002 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 Q58EX2,P25391,P23471,Q7Z5N4,Q9ULI3 215 1.04e-02 4573 7 6 0.857 0.001 TF:M00138_0 tf 1 Factor: Oct-1; motif: NNNNNNNWATGCAAATNNNWNNA; match class: 0 1 P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 1.07e-02 3052 7 5 0.714 0.002 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q58EX2,P23471,P17931,Q7Z5N4,Q9ULI3 215 1.12e-02 116 7 2 0.286 0.017 GO:0007423 BP 1 sensory organ development 1 Q58EX2,Q7Z5N4 215 1.12e-02 307 7 2 0.286 0.007 TF:M04385_1 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 1 1 P08183,Q9ULI3 215 1.22e-02 1916 7 4 0.571 0.002 TF:M04319_1 tf 1 Factor: ESX1; motif: NNYAATTANN; match class: 1 1 P08183,P23471,P17931,Q9ULI3 215 1.22e-02 321 7 2 0.286 0.006 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 P08183,Q7Z5N4 215 1.28e-02 987 7 3 0.429 0.003 TF:M04068_1 tf 1 Factor: POU1F1; motif: NNNATGMATAWTTAATN; match class: 1 1 P23471,P17931,Q9ULI3 215 1.29e-02 330 7 2 0.286 0.006 TF:M04616_1 tf 1 Factor: islet1; motif: NGNTAATG; match class: 1 1 P23471,P17931 215 1.34e-02 4 7 1 0.143 0.250 GO:0002291 BP 1 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 1 P17931 215 1.34e-02 4 7 1 0.143 0.250 GO:0072677 BP 1 eosinophil migration 1 P17931 215 1.34e-02 4 7 1 0.143 0.250 GO:0042910 MF 1 xenobiotic transporter activity 1 P08183 215 1.34e-02 4 7 1 0.143 0.250 GO:0090554 MF 1 phosphatidylcholine-translocating ATPase activity 1 P08183 215 1.34e-02 4 7 1 0.143 0.250 GO:0035620 MF 1 ceramide transporter activity 1 P08183 215 1.34e-02 4 7 1 0.143 0.250 GO:0060219 BP 1 camera-type eye photoreceptor cell differentiation 1 Q58EX2 215 1.42e-02 26 7 1 0.143 0.038 TF:M00437_1 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 1 1 Q9ULI3 215 1.49e-02 4879 7 6 0.857 0.001 TF:M07319_0 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 0 1 Q58EX2,P08183,P25391,P23471,Q7Z5N4,Q9ULI3 215 1.50e-02 4885 7 6 0.857 0.001 TF:M00912_1 tf 1 Factor: C/EBP; motif: NTTRCNNAANNN; match class: 1 1 Q58EX2,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 1.52e-02 6998 7 7 1.000 0.001 TF:M07301_0 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 0 1 Q58EX2,P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 1.53e-02 28 7 1 0.143 0.036 TF:M01112_1 tf 1 Factor: RBP-Jkappa; motif: ANCGTGGGAAM; match class: 1 1 P25391 215 1.59e-02 3338 7 5 0.714 0.001 TF:M07038_1 tf 1 Factor: DBP; motif: TTRCATAANN; match class: 1 1 Q58EX2,P08183,P23471,P17931,Q7Z5N4 215 1.67e-02 5 7 1 0.143 0.200 GO:0035627 BP 1 ceramide transport 1 P08183 215 1.67e-02 5 7 1 0.143 0.200 GO:0043256 CC 1 laminin complex 1 P25391 215 1.67e-02 5 7 1 0.143 0.200 GO:2001200 BP 1 positive regulation of dendritic cell differentiation 1 P17931 215 1.69e-02 1090 7 3 0.429 0.003 TF:M04387_0 tf 1 Factor: LHX6; motif: RCTAATTARN; match class: 0 1 P08183,Q7Z5N4,Q9ULI3 215 1.69e-02 1090 7 3 0.429 0.003 TF:M04387_1 tf 1 Factor: LHX6; motif: RCTAATTARN; match class: 1 1 P08183,Q7Z5N4,Q9ULI3 215 1.87e-02 401 7 2 0.286 0.005 TF:M04322_0 tf 1 Factor: GBX1; motif: NCYAATTANN; match class: 0 1 P08183,Q9ULI3 215 2.00e-02 415 7 2 0.286 0.005 TF:M04432_1 tf 1 Factor: PRRX1; motif: TAATYTAATTA; match class: 1 1 P08183,P23471 215 2.00e-02 6 7 1 0.143 0.167 GO:0002485 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002476 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002489 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002488 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002477 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class Ib 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002481 BP 1 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002428 BP 1 antigen processing and presentation of peptide antigen via MHC class Ib 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002484 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002591 BP 1 positive regulation of antigen processing and presentation of peptide antigen via MHC class I 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0002589 BP 1 regulation of antigen processing and presentation of peptide antigen via MHC class I 1 P08183 215 2.00e-02 6 7 1 0.143 0.167 GO:0019865 MF 1 immunoglobulin binding 1 P17931 215 2.04e-02 1169 7 3 0.429 0.003 TF:M04304_0 tf 1 Factor: DLX6; motif: NYAATTAN; match class: 0 1 P08183,P23471,P17931 215 2.04e-02 1169 7 3 0.429 0.003 TF:M04301_0 tf 1 Factor: DLX3; motif: NYAATTAN; match class: 0 1 P08183,P23471,P17931 215 2.04e-02 1169 7 3 0.429 0.003 TF:M04302_0 tf 1 Factor: DLX4; motif: NYAATTAN; match class: 0 1 P08183,P23471,P17931 215 2.06e-02 2218 7 4 0.571 0.002 TF:M04077_1 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 1 1 P08183,P23471,P17931,Q9ULI3 215 2.07e-02 38 7 1 0.143 0.026 TF:M00638_1 tf 1 Factor: HNF4alpha; motif: VTGAACTTTGMMB; match class: 1 1 P17931 215 2.10e-02 3555 7 5 0.714 0.001 TF:M07059_1 tf 1 Factor: POU2F1; motif: ATGCAAATN; match class: 1 1 Q58EX2,P25391,P23471,Q7Z5N4,Q9ULI3 215 2.23e-02 3602 7 5 0.714 0.001 TF:M07353_0 tf 1 Factor: E2A; motif: CAGNTGNN; match class: 0 1 Q58EX2,P23471,P17931,Q7Z5N4,Q9ULI3 215 2.26e-02 443 7 2 0.286 0.005 TF:M00228_0 tf 1 Factor: VBP; motif: GTTACRTMAT; match class: 0 1 P17931,Q7Z5N4 215 2.32e-02 449 7 2 0.286 0.004 TF:M06949_0 tf 1 Factor: EVX2; motif: WAATTAAATT; match class: 0 1 P08183,P23471 215 2.34e-02 7 7 1 0.143 0.143 GO:0002583 BP 1 regulation of antigen processing and presentation of peptide antigen 1 P08183 215 2.34e-02 7 7 1 0.143 0.143 GO:0002475 BP 1 antigen processing and presentation via MHC class Ib 1 P08183 215 2.34e-02 7 7 1 0.143 0.143 GO:0046624 MF 1 sphingolipid transporter activity 1 P08183 215 2.34e-02 7 7 1 0.143 0.143 GO:0050860 BP 1 negative regulation of T cell receptor signaling pathway 1 P17931 215 2.34e-02 7 7 1 0.143 0.143 GO:0050858 BP 1 negative regulation of antigen receptor-mediated signaling pathway 1 P17931 215 2.34e-02 7 7 1 0.143 0.143 GO:2001198 BP 1 regulation of dendritic cell differentiation 1 P17931 215 2.34e-02 7 7 1 0.143 0.143 GO:0008525 MF 1 phosphatidylcholine transporter activity 1 P08183 215 2.34e-02 7 7 1 0.143 0.143 GO:0002585 BP 1 positive regulation of antigen processing and presentation of peptide antigen 1 P08183 215 2.34e-02 7 7 1 0.143 0.143 GO:0048246 BP 1 macrophage chemotaxis 1 P17931 215 2.34e-02 43 7 1 0.143 0.023 TF:M06948_0 tf 1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 0 1 Q9ULI3 215 2.41e-02 3667 7 5 0.714 0.001 TF:M00739_0 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 0 1 Q58EX2,P08183,P23471,P17931,Q7Z5N4 215 2.50e-02 1 7 1 0.143 1.000 OMIM:615960 omi 1 PORETTI-BOLTSHAUSER SYNDROME; PTBHS 1 P25391 215 2.50e-02 1 7 1 0.143 1.000 OMIM:612244 omi 1 INFLAMMATORY BOWEL DISEASE 13; IBD13 1 P08183 215 2.50e-02 1 7 1 0.143 1.000 OMIM:120080 omi 1 COLCHICINE RESISTANCE;;COLCHICINE SENSITIVITY; CLCS 1 P08183 215 2.53e-02 7530 7 7 1.000 0.001 TF:M07059_0 tf 1 Factor: POU2F1; motif: ATGCAAATN; match class: 0 1 Q58EX2,P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 2.61e-02 48 7 1 0.143 0.021 TF:M04386_1 tf 1 Factor: LHX2; motif: YAATTANNCTAATTR; match class: 1 1 P25391 215 2.63e-02 480 7 2 0.286 0.004 TF:M01890_0 tf 1 Factor: STAT5A; motif: NNNTTTCTNRGAA; match class: 0 1 P25391,P17931 215 2.66e-02 49 7 1 0.143 0.020 TF:M06325_0 tf 1 Factor: ZNF585A; motif: ATGTNTAAAAWC; match class: 0 1 P17931 215 2.67e-02 8 7 1 0.143 0.125 GO:0015238 MF 1 drug transmembrane transporter activity 1 P08183 215 2.67e-02 8 7 1 0.143 0.125 GO:0002483 BP 1 antigen processing and presentation of endogenous peptide antigen 1 P08183 215 2.67e-02 8 7 1 0.143 0.125 GO:0019885 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I 1 P08183 215 2.67e-02 8 7 1 0.143 0.125 GO:1905517 BP 1 macrophage migration 1 P17931 215 2.73e-02 490 7 2 0.286 0.004 TF:M00066_0 tf 1 Factor: Tal-1alpha:E47; motif: NNNAACAGATGKTNNN; match class: 0 1 P23471,Q9ULI3 215 2.87e-02 503 7 2 0.286 0.004 TF:M07213_0 tf 1 Factor: GATA2; motif: NNNTTCTTATCTSN; match class: 0 1 Q58EX2,P08183 215 2.98e-02 513 7 2 0.286 0.004 TF:M04314_0 tf 1 Factor: EMX2; motif: NNTAATTANN; match class: 0 1 P08183,Q9ULI3 215 2.99e-02 7712 7 7 1.000 0.001 TF:M00347_1 tf 1 Factor: GATA-1; motif: MNAGATAANR; match class: 1 1 Q58EX2,P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 3.00e-02 9 7 1 0.143 0.111 GO:0005605 CC 1 basal lamina 1 P25391 215 3.00e-02 9 7 1 0.143 0.111 GO:0002579 BP 1 positive regulation of antigen processing and presentation 1 P08183 215 3.00e-02 9 7 1 0.143 0.111 GO:0019883 BP 1 antigen processing and presentation of endogenous antigen 1 P08183 215 3.09e-02 5578 7 6 0.857 0.001 TF:M01872_0 tf 1 Factor: DBP; motif: TTWTGYAA; match class: 0 1 Q58EX2,P08183,P23471,P17931,Q7Z5N4,Q9ULI3 215 3.11e-02 462 7 2 0.286 0.004 MI:mmu-miR-682 mi 1 MI:mmu-miR-682 1 P08183,P25391 215 3.15e-02 58 7 1 0.143 0.017 TF:M04424_1 tf 1 Factor: PDX1; motif: NYAATTARNNNTAATTAN; match class: 1 1 P08183 215 3.16e-02 3902 7 5 0.714 0.001 TF:M04068_0 tf 1 Factor: POU1F1; motif: NNNATGMATAWTTAATN; match class: 0 1 P08183,P25391,P23471,P17931,Q9ULI3 215 3.24e-02 537 7 2 0.286 0.004 TF:M01823_1 tf 1 Factor: STAT1; motif: TTMNRGGAAN; match class: 1 1 Q58EX2,P17931 215 3.26e-02 2529 7 4 0.571 0.002 TF:M04431_1 tf 1 Factor: PRRX1; motif: NYAATTAN; match class: 1 1 P08183,P23471,P17931,Q9ULI3 215 3.26e-02 678 7 3 0.429 0.004 GO:0007155 BP 1 cell adhesion 1 Q58EX2,P17931,Q7Z5N4 215 3.30e-02 542 7 2 0.286 0.004 TF:M01877_1 tf 1 Factor: GATA-2; motif: GATAANN; match class: 1 1 P08183,P17931 215 3.35e-02 684 7 3 0.429 0.004 GO:0022610 BP 1 biological adhesion 1 Q58EX2,P17931,Q7Z5N4 215 3.55e-02 7903 7 7 1.000 0.001 TF:M03876_0 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 0 1 Q58EX2,P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 3.63e-02 4029 7 5 0.714 0.001 TF:M01199_1 tf 1 Factor: RNF96; motif: BCCCGCRGCC; match class: 1 1 Q58EX2,P25391,P17931,Q7Z5N4,Q9ULI3 215 3.67e-02 4039 7 5 0.714 0.001 TF:M07354_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 Q58EX2,P25391,P23471,Q7Z5N4,Q9ULI3 215 3.67e-02 11 7 1 0.143 0.091 GO:0071677 BP 1 positive regulation of mononuclear cell migration 1 P17931 215 3.67e-02 11 7 1 0.143 0.091 GO:0002577 BP 1 regulation of antigen processing and presentation 1 P08183 215 3.67e-02 11 7 1 0.143 0.091 GO:0090484 MF 1 drug transporter activity 1 P08183 215 3.68e-02 68 7 1 0.143 0.015 TF:M05727_0 tf 1 Factor: ZNF674; motif: NGTTMAAAAAWA; match class: 0 1 Q7Z5N4 215 3.70e-02 213 7 2 0.286 0.009 GO:0045202 CC 1 synapse 1 Q58EX2,Q7Z5N4 215 3.73e-02 69 7 1 0.143 0.014 TF:M06089_0 tf 1 Factor: ZNF26; motif: NAMTCAAGSGTA; match class: 0 1 P17931 215 3.75e-02 581 7 2 0.286 0.003 TF:M01666_0 tf 1 Factor: STAT4; motif: TTCMNAGAADHNMA; match class: 0 1 Q58EX2,P25391 215 3.76e-02 4064 7 5 0.714 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 P08183,P25391,P23471,Q7Z5N4,Q9ULI3 215 3.81e-02 2647 7 4 0.571 0.002 TF:M04343_0 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 0 1 P08183,P23471,Q7Z5N4,Q9ULI3 215 3.84e-02 71 7 1 0.143 0.014 TF:M00977_1 tf 1 Factor: EBF; motif: KTCCCYWGRGA; match class: 1 1 P17931 215 3.91e-02 594 7 2 0.286 0.003 TF:M00158_1 tf 1 Factor: COUP-TF,; motif: TGAMCTTTGMMCYT; match class: 1 1 P23471,P17931 215 3.92e-02 595 7 2 0.286 0.003 TF:M00065_0 tf 1 Factor: Tal-1beta:E47; motif: NNNAACAGATGKTNNN; match class: 0 1 P23471,Q9ULI3 215 3.92e-02 1493 7 3 0.429 0.002 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 Q58EX2,P08183,P17931 215 3.99e-02 1504 7 3 0.429 0.002 TF:M05313_0 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 0 1 Q58EX2,Q7Z5N4,Q9ULI3 215 4.00e-02 74 7 1 0.143 0.014 TF:M04322_1 tf 1 Factor: GBX1; motif: NCYAATTANN; match class: 1 1 Q9ULI3 215 4.06e-02 607 7 2 0.286 0.003 TF:M04430_1 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 1 1 P08183,P23471 215 4.11e-02 537 7 2 0.286 0.004 MI:hsa-miR-30c mi 1 MI:hsa-miR-30c 1 P08183,P17931 215 4.27e-02 79 7 1 0.143 0.013 TF:M01111_1 tf 1 Factor: RBP-Jkappa; motif: TTCCCACK; match class: 1 1 P25391 215 4.28e-02 624 7 2 0.286 0.003 TF:M04343_1 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 1 1 P08183,Q9ULI3 215 4.33e-02 5939 7 6 0.857 0.001 TF:M04077_0 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 0 1 P08183,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 4.34e-02 13 7 1 0.143 0.077 GO:0005001 MF 1 transmembrane receptor protein tyrosine phosphatase activity 1 P23471 215 4.34e-02 13 7 1 0.143 0.077 GO:0019198 MF 1 transmembrane receptor protein phosphatase activity 1 P23471 215 4.34e-02 13 7 1 0.143 0.077 GO:0050856 BP 1 regulation of T cell receptor signaling pathway 1 P17931 215 4.34e-02 13 7 1 0.143 0.077 GO:0001754 BP 1 eye photoreceptor cell differentiation 1 Q58EX2 215 4.38e-02 4212 7 5 0.714 0.001 TF:M04075_0 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 0 1 Q58EX2,P08183,P25391,P17931,Q9ULI3 215 4.39e-02 633 7 2 0.286 0.003 TF:M04451_1 tf 1 Factor: VSX2; motif: CTAATTAN; match class: 1 1 P08183,Q9ULI3 215 4.39e-02 633 7 2 0.286 0.003 TF:M04451_0 tf 1 Factor: VSX2; motif: CTAATTAN; match class: 0 1 P08183,Q9ULI3 215 4.48e-02 83 7 1 0.143 0.012 TF:M06720_0 tf 1 Factor: ZNF430; motif: NTGGAGGGCAGA; match class: 0 1 P17931 215 4.60e-02 6006 7 6 0.857 0.001 TF:M00189_1 tf 1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 1 Q58EX2,P25391,P23471,P17931,Q7Z5N4,Q9ULI3 215 4.65e-02 2807 7 4 0.571 0.001 TF:M04384_1 tf 1 Factor: LBX2; motif: NNYAATTANN; match class: 1 1 P08183,P23471,P17931,Q9ULI3 215 4.67e-02 14 7 1 0.143 0.071 GO:0046530 BP 1 photoreceptor cell differentiation 1 Q58EX2 215 4.67e-02 14 7 1 0.143 0.071 GO:0070232 BP 1 regulation of T cell apoptotic process 1 P17931 215 4.69e-02 87 7 1 0.143 0.011 TF:M06603_0 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 0 1 P25391 215 4.79e-02 89 7 1 0.143 0.011 TF:M06132_0 tf 1 Factor: ZNF823; motif: NYYACCAGCCCT; match class: 0 1 Q9ULI3 215 4.83e-02 4310 7 5 0.714 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 Q58EX2,P25391,P17931,Q7Z5N4,Q9ULI3 215 4.85e-02 90 7 1 0.143 0.011 TF:M06087_0 tf 1 Factor: ZNF21; motif: NANTCCTAAAGA; match class: 0 1 P08183 215 4.85e-02 90 7 1 0.143 0.011 TF:M00423_1 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 1 P17931 215 4.92e-02 674 7 2 0.286 0.003 TF:M00451_0 tf 1 Factor: Nkx3-1; motif: NWATAAGTATWT; match class: 0 1 P08183,P23471 215 4.94e-02 4332 7 5 0.714 0.001 TF:M04073_0 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 0 1 Q58EX2,P08183,P25391,P17931,Q9ULI3 215 4.95e-02 92 7 1 0.143 0.011 TF:M04400_1 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 1 1 P25391 215 5.00e-02 15 7 1 0.143 0.067 GO:0001772 CC 1 immunological synapse 1 P17931 215 5.00e-02 7 7 1 0.143 0.143 CORUM:1746 cor 1 SMN containing complex 1 P17931 215 5.00e-02 15 7 1 0.143 0.067 GO:0097028 BP 1 dendritic cell differentiation 1 P17931 215 5.00e-02 15 7 1 0.143 0.067 GO:0043236 MF 1 laminin binding 1 P17931 215 5.00e-02 2 7 1 0.143 0.500 HP:0030329 hp 1 Retinal thinning 1 P25391 215 5.00e-02 15 7 1 0.143 0.067 GO:0042056 MF 1 chemoattractant activity 1 P17931 215 5.00e-02 2 7 1 0.143 0.500 OMIM:600263 omi 1 HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO 1 P23471 216 1.12e-09 31 5 4 0.800 0.129 GO:0030049 BP 1 muscle filament sliding 1 P35609,P13535,P09493,P19237 216 1.12e-09 31 5 4 0.800 0.129 GO:0033275 BP 1 actin-myosin filament sliding 1 P35609,P13535,P09493,P19237 216 1.85e-08 61 5 4 0.800 0.066 GO:0070252 BP 1 actin-mediated cell contraction 1 P35609,P13535,P09493,P19237 216 4.81e-08 77 5 4 0.800 0.052 GO:0030048 BP 1 actin filament-based movement 1 P35609,P13535,P09493,P19237 216 6.52e-08 83 5 4 0.800 0.048 GO:0030017 CC 1 sarcomere 1 P35609,P13535,P09493,P19237 216 1.08e-07 94 5 4 0.800 0.043 GO:0030016 CC 1 myofibril 1 P35609,P13535,P09493,P19237 216 1.13e-07 95 5 4 0.800 0.042 GO:0044449 CC 1 contractile fiber part 1 P35609,P13535,P09493,P19237 216 1.45e-07 101 5 4 0.800 0.040 GO:0043292 CC 1 contractile fiber 1 P35609,P13535,P09493,P19237 216 6.00e-07 27 5 3 0.600 0.111 GO:0008307 MF 1 structural constituent of muscle 1 P35609,P13535,P09493 216 1.03e-06 164 5 4 0.800 0.024 GO:0006936 BP 1 muscle contraction 1 P35609,P13535,P09493,P19237 216 1.85e-06 190 5 4 0.800 0.021 GO:0003012 BP 1 muscle system process 1 P35609,P13535,P09493,P19237 216 1.25e-05 306 5 4 0.800 0.013 GO:0015629 CC 1 actin cytoskeleton 1 P35609,P13535,P09493,P19237 216 1.38e-05 75 5 3 0.600 0.040 GO:0006941 BP 1 striated muscle contraction 1 P13535,P09493,P19237 216 4.18e-05 414 5 4 0.800 0.010 GO:0005198 MF 1 structural molecule activity 1 P35609,P13535,P09493,Q8TDM6 216 4.39e-05 419 5 4 0.800 0.010 GO:0030029 BP 1 actin filament-based process 1 P35609,P13535,P09493,P19237 216 5.23e-05 26 5 4 0.800 0.154 REAC:390522 rea 1 Striated Muscle Contraction 1 P35609,P13535,P09493,P19237 216 6.16e-05 13 5 2 0.400 0.154 GO:0045214 BP 1 sarcomere organization 1 P35609,P09493 216 7.85e-05 485 5 4 0.800 0.008 GO:0008092 MF 1 cytoskeletal protein binding 1 P35609,P13535,P09493,Q8TDM6 216 8.29e-05 15 5 2 0.400 0.133 GO:0005865 CC 1 striated muscle thin filament 1 P09493,P19237 216 1.07e-04 17 5 2 0.400 0.118 GO:0036379 CC 1 myofilament 1 P09493,P19237 216 1.35e-04 19 5 2 0.400 0.105 GO:0003009 BP 1 skeletal muscle contraction 1 P13535,P19237 216 1.66e-04 21 5 2 0.400 0.095 GO:0050881 BP 1 musculoskeletal movement 1 P13535,P19237 216 1.66e-04 21 5 2 0.400 0.095 GO:0050879 BP 1 multicellular organismal movement 1 P13535,P19237 216 2.76e-04 27 5 2 0.400 0.074 GO:0030239 BP 1 myofibril assembly 1 P35609,P09493 216 3.24e-04 693 5 4 0.800 0.006 GO:0003008 BP 1 system process 1 P35609,P13535,P09493,P19237 216 6.76e-04 42 5 2 0.400 0.048 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 P35609,P09493 216 7.77e-04 45 5 2 0.400 0.044 GO:0055002 BP 1 striated muscle cell development 1 P35609,P09493 216 1.05e-03 933 5 4 0.800 0.004 GO:0044430 CC 1 cytoskeletal part 1 P35609,P13535,P09493,P19237 216 1.12e-03 54 5 2 0.400 0.037 GO:0055001 BP 1 muscle cell development 1 P35609,P09493 216 1.25e-03 57 5 2 0.400 0.035 GO:0060048 BP 1 cardiac muscle contraction 1 P09493,P19237 216 1.32e-03 18 5 2 0.400 0.111 OMIM:192600 omi 1 Hypertrophic Cardiomyopathy 1 P35609,P09493 216 1.46e-03 1016 5 4 0.800 0.004 GO:0006928 BP 1 movement of cell or subcellular component 1 P35609,P13535,P09493,P19237 216 1.78e-03 68 5 2 0.400 0.029 GO:0006937 BP 1 regulation of muscle contraction 1 P09493,P19237 216 2.28e-03 1 5 1 0.200 1.000 GO:0070080 MF 1 titin Z domain binding 1 P35609 216 2.28e-03 1 5 1 0.200 1.000 GO:0003065 BP 1 positive regulation of heart rate by epinephrine 1 P09493 216 2.28e-03 1 5 1 0.200 1.000 GO:1904753 BP 1 negative regulation of vascular associated smooth muscle cell migration 1 P09493 216 2.47e-03 80 5 2 0.400 0.025 GO:0051146 BP 1 striated muscle cell differentiation 1 P35609,P09493 216 2.78e-03 85 5 2 0.400 0.024 GO:0090257 BP 1 regulation of muscle system process 1 P09493,P19237 216 2.85e-03 1204 5 4 0.800 0.003 GO:0005856 CC 1 cytoskeleton 1 P35609,P13535,P09493,P19237 216 3.26e-03 92 5 2 0.400 0.022 GO:0031032 BP 1 actomyosin structure organization 1 P35609,P09493 216 4.56e-03 2 5 1 0.200 0.500 GO:0001996 BP 1 positive regulation of heart rate by epinephrine-norepinephrine 1 P09493 216 4.56e-03 2 5 1 0.200 0.500 GO:0032059 CC 1 bleb 1 P09493 216 4.56e-03 2 5 1 0.200 0.500 GO:0051695 BP 1 actin filament uncapping 1 P35609 216 4.56e-03 2 5 1 0.200 0.500 GO:0051373 MF 1 FATZ binding 1 P35609 216 4.56e-03 2 5 1 0.200 0.500 GO:0086097 BP 1 phospholipase C-activating angiotensin-activated signaling pathway 1 P35609 216 4.65e-03 110 5 2 0.400 0.018 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 P35609,P09493 216 5.59e-03 1 5 1 0.200 1.000 OMIM:115196 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3; CMH3 1 P09493 216 5.59e-03 1 5 1 0.200 1.000 OMIM:611878 omi 1 CARDIOMYOPATHY, DILATED, 1Y; CMD1YLEFT VENTRICULAR NONCOMPACTION 9, INCLUDED; LVNC9, INCLUDED 1 P09493 216 5.59e-03 1 5 1 0.200 1.000 OMIM:158300 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 7; DA7;;TRISMUS-PSEUDOCAMPTODACTYLY SYNDROME;;MOUTH, INABILITY TO OPEN COMPLETELY, AND SHORT FINGER-FLEXOR TENDONS;;HECHT SYNDROME 1 P13535 216 5.59e-03 1 5 1 0.200 1.000 OMIM:612158 omi 1 CARDIOMYOPATHY, DILATED, 1AA, WITH OR WITHOUT LEFT VENTRICULAR NONCOMPACTION;CMD1AACARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 23, WITH OR WITHOUT VENTRICULARNONCOMPACTION, INCLUDED; CMH23, INCLUDED 1 P35609 216 5.59e-03 1 5 1 0.200 1.000 OMIM:608837 omi 1 CARNEY COMPLEX VARIANT 1 P13535 216 6.29e-03 128 5 2 0.400 0.016 GO:0060047 BP 1 heart contraction 1 P09493,P19237 216 6.49e-03 130 5 2 0.400 0.015 GO:0003015 BP 1 heart process 1 P09493,P19237 216 6.84e-03 3 5 1 0.200 0.333 GO:0030035 BP 1 microspike assembly 1 P35609 216 6.84e-03 3 5 1 0.200 0.333 GO:0032027 MF 1 myosin light chain binding 1 P13535 216 6.84e-03 3 5 1 0.200 0.333 GO:1904706 BP 1 negative regulation of vascular smooth muscle cell proliferation 1 P09493 216 7.41e-03 139 5 2 0.400 0.014 GO:0042692 BP 1 muscle cell differentiation 1 P35609,P09493 216 9.12e-03 4 5 1 0.200 0.250 GO:0017018 MF 1 myosin phosphatase activity 1 P13535 216 9.12e-03 4 5 1 0.200 0.250 GO:0001993 BP 1 regulation of systemic arterial blood pressure by norepinephrine-epinephrine 1 P09493 216 9.12e-03 4 5 1 0.200 0.250 GO:0005862 CC 1 muscle thin filament tropomyosin 1 P09493 216 9.12e-03 4 5 1 0.200 0.250 GO:2001137 BP 1 positive regulation of endocytic recycling 1 P35609 216 9.12e-03 4 5 1 0.200 0.250 GO:0003321 BP 1 positive regulation of blood pressure by epinephrine-norepinephrine 1 P09493 216 9.73e-03 678 5 3 0.600 0.004 GO:0007155 BP 1 cell adhesion 1 P35609,P09493,Q8TDM6 216 9.98e-03 684 5 3 0.600 0.004 GO:0022610 BP 1 biological adhesion 1 P35609,P09493,Q8TDM6 216 1.10e-02 170 5 2 0.400 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 P35609,P09493 216 1.14e-02 5 5 1 0.200 0.200 GO:0010460 BP 1 positive regulation of heart rate 1 P09493 216 1.14e-02 5 5 1 0.200 0.200 GO:0003062 BP 1 regulation of heart rate by chemical signal 1 P09493 216 1.14e-02 5 5 1 0.200 0.200 GO:1904752 BP 1 regulation of vascular associated smooth muscle cell migration 1 P09493 216 1.14e-02 5 5 1 0.200 0.200 GO:1904738 BP 1 vascular associated smooth muscle cell migration 1 P09493 216 1.22e-02 33 5 2 0.400 0.061 HP:0001706 hp 1 Endocardial fibroelastosis 1 P35609,P09493 216 1.22e-02 33 5 2 0.400 0.061 HP:0006673 hp 1 Reduced systolic function 1 P35609,P09493 216 1.22e-02 33 5 2 0.400 0.061 HP:0006670 hp 1 Impaired myocardial contractility 1 P35609,P09493 216 1.37e-02 6 5 1 0.200 0.167 GO:2000009 BP 1 negative regulation of protein localization to cell surface 1 P35609 216 1.37e-02 6 5 1 0.200 0.167 GO:0005861 CC 1 troponin complex 1 P19237 216 1.37e-02 6 5 1 0.200 0.167 GO:2001135 BP 1 regulation of endocytic recycling 1 P35609 216 1.39e-02 434 5 2 0.400 0.005 MI:mmu-miR-463 mi 1 MI:mmu-miR-463 1 P09493,P19237 216 1.40e-02 437 5 2 0.400 0.005 MI:hsa-miR-302d* mi 1 MI:hsa-miR-302d* 1 P09493,P19237 216 1.42e-02 439 5 2 0.400 0.005 MI:hsa-miR-302b* mi 1 MI:hsa-miR-302b* 1 P09493,P19237 216 1.42e-02 193 5 2 0.400 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 P35609,P09493 216 1.43e-02 441 5 2 0.400 0.005 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 P09493,P19237 216 1.45e-02 195 5 2 0.400 0.010 GO:0003779 MF 1 actin binding 1 P13535,P09493 216 1.46e-02 36 5 2 0.400 0.056 HP:0006685 hp 1 Endocardial fibrosis 1 P35609,P09493 216 1.46e-02 36 5 2 0.400 0.056 HP:0011713 hp 1 Left bundle branch block 1 P35609,P09493 216 1.56e-02 461 5 2 0.400 0.004 MI:hsa-miR-589 mi 1 MI:hsa-miR-589 1 P09493,P19237 216 1.59e-02 466 5 2 0.400 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 P09493,P19237 216 1.59e-02 1 5 1 0.200 1.000 HP:0011672 hp 1 Cardiac myxoma 1 P13535 216 1.60e-02 7 5 1 0.200 0.143 GO:0038166 BP 1 angiotensin-activated signaling pathway 1 P35609 216 1.60e-02 7 5 1 0.200 0.143 GO:0045777 BP 1 positive regulation of blood pressure 1 P09493 216 1.60e-02 7 5 1 0.200 0.143 GO:0032982 CC 1 myosin filament 1 P13535 216 1.62e-02 38 5 2 0.400 0.053 HP:0004971 hp 1 Pulmonary artery hypoplasia 1 P35609,P09493 216 1.69e-02 211 5 2 0.400 0.009 GO:0008015 BP 1 blood circulation 1 P09493,P19237 216 1.71e-02 212 5 2 0.400 0.009 GO:0007015 BP 1 actin filament organization 1 P35609,P09493 216 1.71e-02 212 5 2 0.400 0.009 GO:0003013 BP 1 circulatory system process 1 P09493,P19237 216 1.74e-02 214 5 2 0.400 0.009 GO:0044057 BP 1 regulation of system process 1 P09493,P19237 216 1.76e-02 491 5 2 0.400 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 P09493,P19237 216 1.79e-02 217 5 2 0.400 0.009 GO:0061061 BP 1 muscle structure development 1 P35609,P09493 216 1.82e-02 8 5 1 0.200 0.125 GO:1904385 BP 1 cellular response to angiotensin 1 P35609 216 1.82e-02 8 5 1 0.200 0.125 GO:1901017 BP 1 negative regulation of potassium ion transmembrane transporter activity 1 P35609 216 1.82e-02 8 5 1 0.200 0.125 GO:1990874 BP 1 vascular smooth muscle cell proliferation 1 P09493 216 1.82e-02 8 5 1 0.200 0.125 GO:1990776 BP 1 response to angiotensin 1 P35609 216 1.82e-02 8 5 1 0.200 0.125 GO:0045823 BP 1 positive regulation of heart contraction 1 P09493 216 1.82e-02 8 5 1 0.200 0.125 GO:1904705 BP 1 regulation of vascular smooth muscle cell proliferation 1 P09493 216 1.89e-02 1960 5 4 0.800 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P35609,P13535,P09493,P19237 216 1.89e-02 1960 5 4 0.800 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P35609,P13535,P09493,P19237 216 1.98e-02 42 5 2 0.400 0.048 HP:0001723 hp 1 Restrictive cardiomyopathy 1 P35609,P09493 216 2.05e-02 9 5 1 0.200 0.111 GO:0031143 CC 1 pseudopodium 1 P35609 216 2.05e-02 9 5 1 0.200 0.111 GO:0030836 BP 1 positive regulation of actin filament depolymerization 1 P35609 216 2.05e-02 9 5 1 0.200 0.111 GO:0031432 MF 1 titin binding 1 P35609 216 2.07e-02 535 5 2 0.400 0.004 MI:hsa-miR-181a mi 1 MI:hsa-miR-181a 1 P35609,P09493 216 2.08e-02 536 5 2 0.400 0.004 MI:hsa-miR-296-3p mi 1 MI:hsa-miR-296-3p 1 P09493,P19237 216 2.20e-02 552 5 2 0.400 0.004 MI:hsa-miR-181c mi 1 MI:hsa-miR-181c 1 P35609,P09493 216 2.28e-02 45 5 2 0.400 0.044 HP:0011712 hp 1 Right bundle branch block 1 P35609,P09493 216 2.28e-02 10 5 1 0.200 0.100 GO:0014912 BP 1 negative regulation of smooth muscle cell migration 1 P09493 216 2.28e-02 10 5 1 0.200 0.100 GO:1901380 BP 1 negative regulation of potassium ion transmembrane transport 1 P35609 216 2.28e-02 10 5 1 0.200 0.100 GO:1901018 BP 1 positive regulation of potassium ion transmembrane transporter activity 1 P35609 216 2.52e-02 594 5 2 0.400 0.003 MI:mmu-miR-466b-5p mi 1 MI:mmu-miR-466b-5p 1 P09493,P19237 216 2.59e-02 48 5 2 0.400 0.042 HP:0004749 hp 1 Atrial flutter 1 P35609,P09493 216 2.59e-02 48 5 2 0.400 0.042 HP:0100578 hp 1 Lipoatrophy 1 P35609,P09493 216 2.64e-02 265 5 2 0.400 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 P35609,P09493 216 2.73e-02 12 5 1 0.200 0.083 GO:0048662 BP 1 negative regulation of smooth muscle cell proliferation 1 P09493 216 2.73e-02 12 5 1 0.200 0.083 GO:0043267 BP 1 negative regulation of potassium ion transport 1 P35609 216 2.73e-02 12 5 1 0.200 0.083 GO:1901881 BP 1 positive regulation of protein depolymerization 1 P35609 216 2.80e-02 628 5 2 0.400 0.003 MI:hsa-miR-519b-3p mi 1 MI:hsa-miR-519b-3p 1 P09493,P19237 216 2.81e-02 50 5 2 0.400 0.040 HP:0011710 hp 1 Bundle branch block 1 P35609,P09493 216 2.86e-02 635 5 2 0.400 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 P09493,P19237 216 2.89e-02 638 5 2 0.400 0.003 MI:hsa-miR-519c-3p mi 1 MI:hsa-miR-519c-3p 1 P09493,P19237 216 2.96e-02 13 5 1 0.200 0.077 GO:1901381 BP 1 positive regulation of potassium ion transmembrane transport 1 P35609 216 3.03e-02 52 5 2 0.400 0.038 HP:0001279 hp 1 Syncope 1 P35609,P09493 216 3.13e-02 289 5 2 0.400 0.007 GO:0008285 BP 1 negative regulation of cell proliferation 1 P09493,Q8TDM6 216 3.39e-02 55 5 2 0.400 0.036 HP:0009125 hp 1 Lipodystrophy 1 P35609,P09493 216 3.41e-02 15 5 1 0.200 0.067 GO:0005859 CC 1 muscle myosin complex 1 P13535 216 3.64e-02 16 5 1 0.200 0.062 GO:2001259 BP 1 positive regulation of cation channel activity 1 P35609 216 3.64e-02 16 5 1 0.200 0.062 GO:0043243 BP 1 positive regulation of protein complex disassembly 1 P35609 216 3.76e-02 58 5 2 0.400 0.034 HP:0004756 hp 1 Ventricular tachycardia 1 P35609,P09493 216 3.89e-02 159 5 2 0.400 0.013 TF:M01248_1 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 1 1 P35609,Q8TDM6 216 3.89e-02 59 5 2 0.400 0.034 HP:0001699 hp 1 Sudden death 1 P35609,P09493 216 3.89e-02 7 5 1 0.200 0.143 OMIM:108120 omi 1 Distal Arthrogryposes 1 P13535 216 4.02e-02 60 5 2 0.400 0.033 HP:0001678 hp 1 Atrioventricular block 1 P35609,P09493 216 4.02e-02 60 5 2 0.400 0.033 HP:0004306 hp 1 Abnormality of the endocardium 1 P35609,P09493 216 4.09e-02 18 5 1 0.200 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 P35609 216 4.09e-02 18 5 1 0.200 0.056 GO:0030159 MF 1 receptor signaling complex scaffold activity 1 Q8TDM6 216 4.09e-02 18 5 1 0.200 0.056 GO:0000146 MF 1 microfilament motor activity 1 P13535 216 4.09e-02 18 5 1 0.200 0.056 GO:0043268 BP 1 positive regulation of potassium ion transport 1 P35609 216 4.29e-02 62 5 2 0.400 0.032 HP:0001962 hp 1 Palpitations 1 P35609,P09493 216 4.32e-02 19 5 1 0.200 0.053 GO:0014910 BP 1 regulation of smooth muscle cell migration 1 P09493 216 4.52e-02 357 5 3 0.600 0.008 HPA:034010_13 hpa 1 skeletal muscle; myocytes[Supportive,High] 1 P35609,P13535,P09493 216 4.55e-02 20 5 1 0.200 0.050 GO:0016460 CC 1 myosin II complex 1 P13535 216 4.75e-02 358 5 2 0.400 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 P35609,P09493 216 4.80e-02 360 5 2 0.400 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 P35609,P09493 216 4.85e-02 66 5 2 0.400 0.030 HP:0012722 hp 1 Heart block 1 P35609,P09493 216 4.85e-02 66 5 2 0.400 0.030 HP:0005150 hp 1 Abnormal atrioventricular conduction 1 P35609,P09493 216 5.00e-02 22 5 1 0.200 0.045 GO:0030834 BP 1 regulation of actin filament depolymerization 1 P35609 216 5.00e-02 22 5 1 0.200 0.045 GO:0051496 BP 1 positive regulation of stress fiber assembly 1 P09493 216 5.00e-02 138 5 4 0.800 0.029 REAC:397014 rea 1 Muscle contraction 1 P35609,P13535,P09493,P19237 216 5.00e-02 9 5 1 0.200 0.111 OMIM:604169 omi 1 Left Ventricular Noncompaction 1 P09493 216 5.00e-02 111 5 2 0.400 0.018 KEGG:04530 keg 1 Tight junction 1 P35609,P13535 216 5.00e-02 22 5 1 0.200 0.045 GO:0003044 BP 1 regulation of systemic arterial blood pressure mediated by a chemical signal 1 P09493 216 5.00e-02 3654 5 5 1.000 0.001 TF:M03542_1 tf 1 Factor: COUP-TF1; motif: TGACCTY; match class: 1 1 P35609,P13535,P09493,Q8TDM6,P19237 216 5.00e-02 1028 5 4 0.800 0.004 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 P35609,P13535,P09493,P19237 217 2.20e-08 269 5 5 1.000 0.019 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P09012,P41223,O75940,Q92620,Q13838 217 5.78e-08 326 5 5 1.000 0.015 GO:0008380 BP 1 RNA splicing 1 P09012,P41223,O75940,Q92620,Q13838 217 4.14e-07 147 5 4 0.800 0.027 GO:0005681 CC 1 spliceosomal complex 1 P09012,P41223,Q92620,Q13838 217 4.18e-07 228 5 5 1.000 0.022 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P09012,P41223,O75940,Q92620,Q13838 217 2.08e-06 141 5 5 1.000 0.035 CORUM:351 cor 1 Spliceosome 1 P09012,P41223,O75940,Q92620,Q13838 217 3.84e-06 752 5 5 1.000 0.007 GO:0006396 BP 1 RNA processing 1 P09012,P41223,O75940,Q92620,Q13838 217 4.42e-06 265 5 4 0.800 0.015 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P09012,P41223,Q92620,Q13838 217 4.42e-06 265 5 4 0.800 0.015 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P09012,P41223,Q92620,Q13838 217 1.23e-05 342 5 4 0.800 0.012 GO:0006397 BP 1 mRNA processing 1 P09012,P41223,Q92620,Q13838 217 2.17e-05 173 5 4 0.800 0.023 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P09012,P41223,O75940,Q92620 217 2.55e-05 180 5 4 0.800 0.022 REAC:72172 rea 1 mRNA Splicing 1 P09012,P41223,O75940,Q92620 217 6.61e-05 522 5 4 0.800 0.008 GO:0016071 BP 1 mRNA metabolic process 1 P09012,P41223,Q92620,Q13838 217 1.14e-04 599 5 4 0.800 0.007 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P09012,P41223,Q92620,Q13838 217 1.15e-04 600 5 4 0.800 0.007 GO:1990904 CC 1 ribonucleoprotein complex 1 P09012,P41223,Q92620,Q13838 217 2.30e-04 31 5 2 0.400 0.065 GO:0017069 MF 1 snRNA binding 1 P09012,Q13838 217 7.04e-04 54 5 2 0.400 0.037 GO:0097525 CC 1 spliceosomal snRNP complex 1 P09012,Q13838 217 9.00e-04 61 5 2 0.400 0.033 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 P09012,Q13838 217 9.60e-04 63 5 2 0.400 0.032 GO:0006369 BP 1 termination of RNA polymerase II transcription 1 Q92620,Q13838 217 1.02e-03 65 5 2 0.400 0.031 GO:0004004 MF 1 ATP-dependent RNA helicase activity 1 Q92620,Q13838 217 1.05e-03 66 5 2 0.400 0.030 GO:0008186 MF 1 RNA-dependent ATPase activity 1 Q92620,Q13838 217 1.05e-03 66 5 2 0.400 0.030 GO:0003724 MF 1 RNA helicase activity 1 Q92620,Q13838 217 1.34e-03 1118 5 4 0.800 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 P09012,O75940,Q92620,Q13838 217 1.67e-03 83 5 2 0.400 0.024 GO:0031124 BP 1 mRNA 3'-end processing 1 Q92620,Q13838 217 1.87e-03 88 5 2 0.400 0.023 GO:0070035 MF 1 purine NTP-dependent helicase activity 1 Q92620,Q13838 217 1.87e-03 88 5 2 0.400 0.023 GO:0008026 MF 1 ATP-dependent helicase activity 1 Q92620,Q13838 217 2.02e-03 2627 5 5 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 2.37e-03 99 5 2 0.400 0.020 GO:0006353 BP 1 DNA-templated transcription, termination 1 Q92620,Q13838 217 2.42e-03 100 5 2 0.400 0.020 GO:0006406 BP 1 mRNA export from nucleus 1 Q92620,Q13838 217 2.42e-03 100 5 2 0.400 0.020 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q92620,Q13838 217 2.61e-03 104 5 2 0.400 0.019 GO:0051028 BP 1 mRNA transport 1 Q92620,Q13838 217 2.69e-03 1336 5 4 0.800 0.003 GO:0003723 MF 1 RNA binding 1 P09012,O75940,Q92620,Q13838 217 2.86e-03 2 5 1 0.200 0.500 GO:0035614 MF 1 snRNA stem-loop binding 1 P09012 217 2.87e-03 109 5 2 0.400 0.018 GO:0031123 BP 1 RNA 3'-end processing 1 Q92620,Q13838 217 2.98e-03 111 5 2 0.400 0.018 GO:0006405 BP 1 RNA export from nucleus 1 Q92620,Q13838 217 3.03e-03 112 5 2 0.400 0.018 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q92620,Q13838 217 3.03e-03 112 5 2 0.400 0.018 GO:0004386 MF 1 helicase activity 1 Q92620,Q13838 217 3.19e-03 115 5 2 0.400 0.017 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q92620,Q13838 217 3.56e-03 1830 5 4 0.800 0.002 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 P09012,P41223,Q92620,Q13838 217 3.77e-03 125 5 2 0.400 0.016 GO:0050657 BP 1 nucleic acid transport 1 Q92620,Q13838 217 3.77e-03 125 5 2 0.400 0.016 GO:0050658 BP 1 RNA transport 1 Q92620,Q13838 217 3.95e-03 128 5 2 0.400 0.016 GO:0051236 BP 1 establishment of RNA localization 1 Q92620,Q13838 217 4.01e-03 3013 5 5 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 4.30e-03 3 5 1 0.200 0.333 GO:0043008 MF 1 ATP-dependent protein binding 1 Q13838 217 4.30e-03 3 5 1 0.200 0.333 GO:2000002 BP 1 negative regulation of DNA damage checkpoint 1 Q13838 217 4.30e-03 3 5 1 0.200 0.333 GO:2000825 BP 1 positive regulation of androgen receptor activity 1 P41223 217 4.32e-03 3058 5 5 1.000 0.002 GO:0010467 BP 1 gene expression 1 P09012,P41223,O75940,Q92620,Q13838 217 4.85e-03 142 5 2 0.400 0.014 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q92620,Q13838 217 5.08e-03 1485 5 5 1.000 0.003 REAC:74160 rea 1 Gene Expression 1 P09012,P41223,O75940,Q92620,Q13838 217 5.63e-03 153 5 2 0.400 0.013 GO:0051168 BP 1 nuclear export 1 Q92620,Q13838 217 5.73e-03 4 5 1 0.200 0.250 GO:0030619 MF 1 U1 snRNA binding 1 P09012 217 5.73e-03 4 5 1 0.200 0.250 GO:1901977 BP 1 negative regulation of cell cycle checkpoint 1 Q13838 217 5.73e-03 4 5 1 0.200 0.250 GO:2000823 BP 1 regulation of androgen receptor activity 1 P41223 217 6.00e-03 158 5 2 0.400 0.013 GO:0006403 BP 1 RNA localization 1 Q92620,Q13838 217 6.98e-03 52 5 2 0.400 0.038 REAC:72187 rea 1 mRNA 3'-end processing 1 Q92620,Q13838 217 7.16e-03 5 5 1 0.200 0.200 GO:0030621 MF 1 U4 snRNA binding 1 Q13838 217 7.19e-03 298 5 2 0.400 0.007 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 P09012,Q13838 217 7.81e-03 3443 5 5 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 9.16e-03 3554 5 5 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 9.25e-03 3561 5 5 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 9.34e-03 341 5 2 0.400 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 P09012,Q13838 217 9.61e-03 61 5 2 0.400 0.033 REAC:73856 rea 1 RNA Polymerase II Transcription Termination 1 Q92620,Q13838 217 9.61e-03 61 5 2 0.400 0.033 REAC:109688 rea 1 Cleavage of Growing Transcript in the Termination Region 1 Q92620,Q13838 217 1.00e-02 7 5 1 0.200 0.143 GO:0033145 BP 1 positive regulation of intracellular steroid hormone receptor signaling pathway 1 P41223 217 1.00e-02 7 5 1 0.200 0.143 GO:0005688 CC 1 U6 snRNP 1 Q13838 217 1.09e-02 3681 5 5 1.000 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 1.14e-02 8 5 1 0.200 0.125 GO:0046784 BP 1 viral mRNA export from host cell nucleus 1 Q13838 217 1.14e-02 8 5 1 0.200 0.125 GO:0035613 MF 1 RNA stem-loop binding 1 P09012 217 1.19e-02 68 5 2 0.400 0.029 REAC:159236 rea 1 Transport of Mature mRNA derived from an Intron-Containing Transcript 1 Q92620,Q13838 217 1.43e-02 10 5 1 0.200 0.100 GO:0017070 MF 1 U6 snRNA binding 1 Q13838 217 1.43e-02 10 5 1 0.200 0.100 GO:2000001 BP 1 regulation of DNA damage checkpoint 1 Q13838 217 1.43e-02 10 5 1 0.200 0.100 GO:0005687 CC 1 U4 snRNP 1 Q13838 217 1.45e-02 75 5 2 0.400 0.027 REAC:72202 rea 1 Transport of Mature Transcript to Cytoplasm 1 Q92620,Q13838 217 1.55e-02 3948 5 5 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 1.65e-02 264 5 2 0.400 0.008 GO:0042623 MF 1 ATPase activity, coupled 1 Q92620,Q13838 217 1.65e-02 2136 5 4 0.800 0.002 GO:0003676 MF 1 nucleic acid binding 1 P09012,O75940,Q92620,Q13838 217 1.86e-02 13 5 1 0.200 0.077 GO:0000346 CC 1 transcription export complex 1 Q13838 217 1.87e-02 489 5 2 0.400 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P09012,Q13838 217 2.02e-02 509 5 2 0.400 0.004 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 P09012,P41223 217 2.23e-02 4 5 1 0.200 0.250 CORUM:1148 cor 1 snRNP-free U1A (SF-A) complex 1 P09012 217 2.28e-02 4264 5 5 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 2.37e-02 318 5 2 0.400 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q92620,Q13838 217 2.43e-02 17 5 1 0.200 0.059 GO:0005685 CC 1 U1 snRNP 1 P09012 217 2.43e-02 53 5 1 0.200 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q13838 217 2.45e-02 564 5 2 0.400 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 P09012,Q13838 217 2.46e-02 324 5 2 0.400 0.006 GO:0051169 BP 1 nuclear transport 1 Q92620,Q13838 217 2.71e-02 19 5 1 0.200 0.053 GO:2000273 BP 1 positive regulation of receptor activity 1 P41223 217 2.76e-02 4430 5 5 1.000 0.001 GO:0005634 CC 1 nucleus 1 P09012,P41223,O75940,Q92620,Q13838 217 2.85e-02 20 5 1 0.200 0.050 GO:0060765 BP 1 regulation of androgen receptor signaling pathway 1 P41223 217 2.92e-02 354 5 2 0.400 0.006 GO:0016887 MF 1 ATPase activity 1 Q92620,Q13838 217 2.99e-02 1177 5 3 0.600 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 P41223,Q92620,Q13838 217 3.10e-02 639 5 2 0.400 0.003 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 P09012,Q13838 217 3.14e-02 22 5 1 0.200 0.045 GO:0032786 BP 1 positive regulation of DNA-templated transcription, elongation 1 Q13838 217 3.25e-02 374 5 2 0.400 0.005 GO:0071705 BP 1 nitrogen compound transport 1 Q92620,Q13838 217 3.51e-02 682 5 2 0.400 0.003 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 P09012,Q13838 217 3.55e-02 2612 5 4 0.800 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 P09012,O75940,Q92620,Q13838 217 3.57e-02 25 5 1 0.200 0.040 GO:1901976 BP 1 regulation of cell cycle checkpoint 1 Q13838 217 3.61e-02 409 5 3 0.600 0.007 MI:hsa-miR-375 mi 1 MI:hsa-miR-375 1 P41223,O75940,Q92620 217 3.80e-02 2660 5 4 0.800 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 P09012,O75940,Q92620,Q13838 217 3.90e-02 7 5 1 0.200 0.143 CORUM:770 cor 1 TREX complex 1 Q13838 217 3.90e-02 7 5 1 0.200 0.143 CORUM:785 cor 1 Exon junction complex 1 Q13838 217 4.24e-02 755 5 2 0.400 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 P09012,Q13838 217 4.30e-02 761 5 2 0.400 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P09012,Q13838 217 4.32e-02 438 5 3 0.600 0.007 TF:M05480_0 tf 1 Factor: TLX; motif: AAAAATCARK; match class: 0 1 P09012,O75940,Q13838 217 4.62e-02 1985 5 3 0.600 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 P41223,Q92620,Q13838 217 4.74e-02 802 5 2 0.400 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q92620,Q13838 217 4.90e-02 2029 5 3 0.600 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 P09012,Q92620,Q13838 217 5.00e-02 457 5 3 0.600 0.007 MI:hsa-miR-224 mi 1 MI:hsa-miR-224 1 P09012,P41223,Q92620 217 5.00e-02 128 5 5 1.000 0.039 KEGG:03040 keg 1 Spliceosome 1 P09012,P41223,O75940,Q92620,Q13838 217 5.00e-02 9 5 1 0.200 0.111 CORUM:1751 cor 1 SMN complex 1 P09012 217 5.00e-02 4990 5 5 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 P09012,P41223,O75940,Q92620,Q13838 217 5.00e-02 140 5 2 0.400 0.014 REAC:73857 rea 1 RNA Polymerase II Transcription 1 Q92620,Q13838 217 5.00e-02 86 5 2 0.400 0.023 TF:M03977_1 tf 1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 1 P41223,Q13838 218 3.99e-06 3 6 2 0.333 0.667 GO:0032807 CC 1 DNA ligase IV complex 1 Q13426,P49917 218 7.98e-06 4 6 2 0.333 0.500 GO:0005958 CC 1 DNA-dependent protein kinase-DNA ligase 4 complex 1 Q13426,P49917 218 1.99e-05 6 6 2 0.333 0.333 GO:0000012 BP 1 single strand break repair 1 Q7Z2E3,P49917 218 2.00e-05 7 6 2 0.333 0.286 REAC:164843 rea 1 2-LTR circle formation 1 Q13426,P49917 218 3.42e-05 9 6 2 0.333 0.222 REAC:162592 rea 1 Integration of provirus 1 Q13426,P49917 218 3.63e-05 2 6 2 0.333 1.000 CORUM:354 cor 1 DNA ligase IV-XRCC4 complex 1 Q13426,P49917 218 3.63e-05 2 6 2 0.333 1.000 CORUM:344 cor 1 DNA ligase IV-XRCC4 complex (LX complex) 1 Q13426,P49917 218 3.63e-05 2 6 2 0.333 1.000 CORUM:345 cor 1 DNA ligase IV-XRCC4 complex (LX complex) 1 Q13426,P49917 218 3.63e-05 2 6 2 0.333 1.000 CORUM:352 cor 1 DNA ligase IV-XRCC4 complex 1 Q13426,P49917 218 3.63e-05 2 6 2 0.333 1.000 CORUM:206 cor 1 DNA ligase IV-XRCC4 complex 1 Q13426,P49917 218 3.72e-05 8 6 2 0.333 0.250 GO:0075713 BP 1 establishment of integrated proviral latency 1 Q13426,P49917 218 3.72e-05 8 6 2 0.333 0.250 GO:0019043 BP 1 establishment of viral latency 1 Q13426,P49917 218 4.78e-05 9 6 2 0.333 0.222 GO:0070419 CC 1 nonhomologous end joining complex 1 Q13426,P49917 218 5.98e-05 10 6 2 0.333 0.200 GO:0019042 BP 1 viral latency 1 Q13426,P49917 218 6.26e-05 12 6 2 0.333 0.167 REAC:162594 rea 1 Early Phase of HIV Life Cycle 1 Q13426,P49917 218 8.76e-05 12 6 2 0.333 0.167 GO:0051103 BP 1 DNA ligation involved in DNA repair 1 Q13426,P49917 218 1.09e-04 3 6 2 0.333 0.667 CORUM:359 cor 1 DNA ligase IV-XRCC4-XLF complex 1 Q13426,P49917 218 1.09e-04 3 6 2 0.333 0.667 CORUM:336 cor 1 DNA ligase IV-XRCC4-AHNK complex 1 Q13426,P49917 218 1.09e-04 3 6 2 0.333 0.667 CORUM:350 cor 1 DNA ligase IV-XRCC4-PNK complex 1 Q13426,P49917 218 1.21e-04 14 6 2 0.333 0.143 GO:0010165 BP 1 response to X-ray 1 Q13426,P49917 218 2.03e-04 18 6 2 0.333 0.111 GO:0006266 BP 1 DNA ligation 1 Q13426,P49917 218 7.58e-04 7 6 2 0.333 0.286 CORUM:1189 cor 1 DNA double-strand break end-joining complex 1 Q13426,P49917 218 8.79e-04 37 6 2 0.333 0.054 GO:1990391 CC 1 DNA repair complex 1 Q13426,P49917 218 9.43e-04 2 6 1 0.167 0.500 TF:M05631_0 tf 1 Factor: ZNF210; motif: NGKTAGGGCAGA; match class: 0 1 Q0D2I5 218 9.70e-04 46 6 2 0.333 0.043 REAC:5693571 rea 1 Nonhomologous End-Joining (NHEJ) 1 Q13426,P49917 218 1.49e-03 48 6 2 0.333 0.042 GO:0006303 BP 1 double-strand break repair via nonhomologous end joining 1 Q13426,P49917 218 1.81e-03 53 6 2 0.333 0.038 GO:0000726 BP 1 non-recombinational repair 1 Q13426,P49917 218 2.12e-03 531 6 3 0.500 0.006 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q7Z2E3,Q13426,P49917 218 3.07e-03 1 6 1 0.167 1.000 GO:0002568 BP 1 somatic diversification of T cell receptor genes 1 P49917 218 3.07e-03 1 6 1 0.167 1.000 GO:0051102 BP 1 DNA ligation involved in DNA recombination 1 P49917 218 3.07e-03 1 6 1 0.167 1.000 GO:0002681 BP 1 somatic recombination of T cell receptor gene segments 1 P49917 218 3.07e-03 1 6 1 0.167 1.000 GO:0033153 BP 1 T cell receptor V(D)J recombination 1 P49917 218 3.07e-03 1 6 1 0.167 1.000 GO:0033699 MF 1 DNA 5'-adenosine monophosphate hydrolase activity 1 Q7Z2E3 218 3.20e-03 190 6 2 0.333 0.011 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 Q5TF58,Q1L5Z9 218 3.77e-03 8 6 1 0.167 0.125 TF:M06318_0 tf 1 Factor: ZFP192; motif: NTGTMAAAAATC; match class: 0 1 Q7Z2E3 218 3.92e-03 658 6 3 0.500 0.005 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.01e-03 384 6 3 0.500 0.008 GO:0006281 BP 1 DNA repair 1 Q7Z2E3,Q13426,P49917 218 4.03e-03 79 6 2 0.333 0.025 GO:0010212 BP 1 response to ionizing radiation 1 Q13426,P49917 218 5.18e-03 11 6 1 0.167 0.091 TF:M06519_0 tf 1 Factor: ZNF397; motif: NCGKGGATMAGA; match class: 0 1 Q5TF58 218 5.64e-03 12 6 1 0.167 0.083 TF:M00065_1 tf 1 Factor: Tal-1beta:E47; motif: NNNAACAGATGKTNNN; match class: 1 1 Q0D2I5 218 5.72e-03 217 6 2 0.333 0.009 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 Q7Z2E3,Q13426 218 6.14e-03 2 6 1 0.167 0.500 GO:0008967 MF 1 phosphoglycolate phosphatase activity 1 Q7Z2E3 218 6.14e-03 2 6 1 0.167 0.500 GO:0033152 BP 1 immunoglobulin V(D)J recombination 1 P49917 218 6.19e-03 98 6 2 0.333 0.020 GO:0000793 CC 1 condensed chromosome 1 Q13426,P49917 218 7.50e-03 108 6 2 0.333 0.019 GO:0008022 MF 1 protein C-terminus binding 1 Q13426,P49917 218 8.44e-03 137 6 2 0.333 0.015 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 Q13426,P49917 218 8.46e-03 18 6 1 0.167 0.056 TF:M06986_0 tf 1 Factor: znf581; motif: NCTTCTARAAGG; match class: 0 1 Q1L5Z9 218 8.46e-03 18 6 1 0.167 0.056 TF:M05576_0 tf 1 Factor: ZFP92; motif: NCGATAAAATGM; match class: 0 1 Q13426 218 8.80e-03 140 6 2 0.333 0.014 REAC:162587 rea 1 HIV Life Cycle 1 Q13426,P49917 218 9.21e-03 3 6 1 0.167 0.333 GO:0097680 BP 1 double-strand break repair via classical nonhomologous end joining 1 P49917 218 1.01e-02 919 6 3 0.500 0.003 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 1.03e-02 22 6 1 0.167 0.045 TF:M06723_0 tf 1 Factor: ZNF492; motif: KGGTRAGGAAGA; match class: 0 1 Q7Z2E3 218 1.08e-02 942 6 3 0.500 0.003 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 1.13e-02 133 6 2 0.333 0.015 GO:0016874 MF 1 ligase activity 1 Q13426,P49917 218 1.16e-02 965 6 3 0.500 0.003 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q7Z2E3,Q13426,P49917 218 1.23e-02 4 6 1 0.167 0.250 GO:0051351 BP 1 positive regulation of ligase activity 1 Q13426 218 1.28e-02 341 6 2 0.333 0.006 MI:hsa-miR-136* mi 1 MI:hsa-miR-136* 1 Q0D2I5,Q13426 218 1.31e-02 28 6 1 0.167 0.036 TF:M05869_0 tf 1 Factor: ZNF454; motif: NTGGYTKAAATC; match class: 0 1 Q5TF58 218 1.33e-02 6 6 1 0.167 0.167 HP:0005365 hp 1 Severe B lymphocytopenia 1 P49917 218 1.41e-02 592 6 3 0.500 0.005 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q7Z2E3,Q13426,P49917 218 1.51e-02 154 6 2 0.333 0.013 GO:0006302 BP 1 double-strand break repair 1 Q13426,P49917 218 1.53e-02 609 6 3 0.500 0.005 GO:0005694 CC 1 chromosome 1 Q7Z2E3,Q13426,P49917 218 1.53e-02 5 6 1 0.167 0.200 GO:0003910 MF 1 DNA ligase (ATP) activity 1 P49917 218 1.53e-02 5 6 1 0.167 0.200 GO:0051340 BP 1 regulation of ligase activity 1 Q13426 218 1.53e-02 5 6 1 0.167 0.200 GO:0002328 BP 1 pro-B cell differentiation 1 P49917 218 1.54e-02 427 6 2 0.333 0.005 TF:M03954_0 tf 1 Factor: CUX2; motif: TRATCGATAN; match class: 0 1 Q7Z2E3,Q13426 218 1.55e-02 7 6 1 0.167 0.143 HP:0006349 hp 1 Agenesis of permanent teeth 1 P49917 218 1.55e-02 7 6 1 0.167 0.143 HP:0011044 hp 1 Abnormal number of permanent teeth 1 P49917 218 1.59e-02 368 6 2 0.333 0.005 HPA:022020_13 hpa 1 lung; pneumocytes[Supportive,High] 1 Q7Z2E3,Q13426 218 1.61e-02 2511 6 4 0.667 0.002 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q7Z2E3,Q13426,Q1L5Z9,P49917 218 1.61e-02 385 6 2 0.333 0.005 MI:mmu-miR-881 mi 1 MI:mmu-miR-881 1 Q13426,P49917 218 1.62e-02 2515 6 4 0.667 0.002 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 Q7Z2E3,Q5TF58,Q1L5Z9,P49917 218 1.66e-02 1294 6 3 0.500 0.002 TF:M04147_0 tf 1 Factor: TFAP2A; motif: NGCCYSAGGCN; match class: 0 1 Q13426,Q5TF58,Q1L5Z9 218 1.67e-02 1100 6 3 0.500 0.003 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 1.67e-02 1 6 1 0.167 1.000 OMIM:606593 omi 1 LIG4 SYNDROME 1 P49917 218 1.67e-02 1 6 1 0.167 1.000 OMIM:616541 omi 1 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION; SSMED 1 Q13426 218 1.78e-02 391 6 2 0.333 0.005 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 Q7Z2E3,Q13426 218 1.79e-02 1129 6 3 0.500 0.003 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q7Z2E3,Q13426,P49917 218 1.81e-02 394 6 2 0.333 0.005 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 Q7Z2E3,Q13426 218 1.84e-02 6 6 1 0.167 0.167 GO:0002320 BP 1 lymphoid progenitor cell differentiation 1 P49917 218 1.84e-02 6 6 1 0.167 0.167 GO:0035312 MF 1 5'-3' exodeoxyribonuclease activity 1 Q7Z2E3 218 1.90e-02 404 6 2 0.333 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q7Z2E3,Q13426 218 1.91e-02 478 6 2 0.333 0.004 TF:M00085_0 tf 1 Factor: ZID; motif: NGGCTCYATCAYC; match class: 0 1 Q0D2I5,Q5TF58 218 1.92e-02 41 6 1 0.167 0.024 TF:M05512_0 tf 1 Factor: ZNF575; motif: NGGTGGGGGGGC; match class: 0 1 P49917 218 1.93e-02 408 6 2 0.333 0.005 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q7Z2E3,Q13426 218 2.02e-02 1179 6 3 0.500 0.003 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 2.02e-02 670 6 3 0.500 0.004 GO:0006259 BP 1 DNA metabolic process 1 Q7Z2E3,Q13426,P49917 218 2.08e-02 2286 6 4 0.667 0.002 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q7Z2E3,Q13426,Q5TF58,P49917 218 2.09e-02 501 6 2 0.333 0.004 TF:M01078_1 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 1 Q13426,P49917 218 2.10e-02 219 6 2 0.333 0.009 REAC:162906 rea 1 HIV Infection 1 Q13426,P49917 218 2.10e-02 45 6 1 0.167 0.022 TF:M05672_0 tf 1 Factor: ZNF133; motif: NARTGAAAAAGA; match class: 0 1 Q1L5Z9 218 2.13e-02 446 6 2 0.333 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q0D2I5,Q7Z2E3 218 2.15e-02 7 6 1 0.167 0.143 GO:0003909 MF 1 DNA ligase activity 1 P49917 218 2.15e-02 46 6 1 0.167 0.022 TF:M06890_0 tf 1 Factor: ZNF658; motif: NTGGNGAAGAGC; match class: 0 1 Q1L5Z9 218 2.15e-02 46 6 1 0.167 0.022 TF:M06889_0 tf 1 Factor: znf658b; motif: NTGGNGAAGAGC; match class: 0 1 Q1L5Z9 218 2.18e-02 512 6 2 0.333 0.004 TF:M00192_1 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 1 1 Q1L5Z9,P49917 218 2.21e-02 10 6 1 0.167 0.100 HP:0000571 hp 1 Hypometric saccades 1 Q7Z2E3 218 2.32e-02 1242 6 3 0.500 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 2.43e-02 1263 6 3 0.500 0.002 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 Q7Z2E3,Q13426,P49917 218 2.43e-02 11 6 1 0.167 0.091 HP:0003387 hp 1 Decreased number of large peripheral myelinated nerve fibers 1 Q7Z2E3 218 2.43e-02 11 6 1 0.167 0.091 HP:0000220 hp 1 Velopharyngeal insufficiency 1 P49917 218 2.43e-02 11 6 1 0.167 0.091 HP:0005338 hp 1 Sparse lateral eyebrow 1 P49917 218 2.45e-02 8 6 1 0.167 0.125 GO:0033151 BP 1 V(D)J recombination 1 P49917 218 2.49e-02 1274 6 3 0.500 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 2.52e-02 54 6 1 0.167 0.019 TF:M03884_1 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 1 1 Q0D2I5 218 2.57e-02 55 6 1 0.167 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 P49917 218 2.59e-02 476 6 2 0.333 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 Q7Z2E3,Q13426 218 2.64e-02 567 6 2 0.333 0.004 TF:M05876_0 tf 1 Factor: ZNF526; motif: KGGGTGGGGWRC; match class: 0 1 Q5TF58,Q1L5Z9 218 2.65e-02 12 6 1 0.167 0.083 HP:0004430 hp 1 Severe combined immunodeficiency 1 P49917 218 2.66e-02 501 6 2 0.333 0.004 MI:mmu-miR-465a-3p mi 1 MI:mmu-miR-465a-3p 1 Q0D2I5,P49917 218 2.71e-02 2901 6 4 0.667 0.001 TF:M02105_0 tf 1 Factor: NF-E4; motif: CHCCCTCKCCWG; match class: 0 1 Q0D2I5,Q13426,Q5TF58,Q1L5Z9 218 2.72e-02 576 6 2 0.333 0.003 TF:M04112_0 tf 1 Factor: GMEB2; motif: TTACGYAM; match class: 0 1 Q5TF58,P49917 218 2.76e-02 4666 6 5 0.833 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 Q0D2I5,Q7Z2E3,Q13426,Q5TF58,P49917 218 2.79e-02 2925 6 4 0.667 0.001 TF:M00671_0 tf 1 Factor: TCF-4; motif: SCTTTGAW; match class: 0 1 Q7Z2E3,Q13426,Q5TF58,Q1L5Z9 218 2.84e-02 1337 6 3 0.500 0.002 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q7Z2E3,Q13426,P49917 218 2.84e-02 61 6 1 0.167 0.016 TF:M05443_0 tf 1 Factor: TBX15; motif: AGGTGTGAAAN; match class: 0 1 Q5TF58 218 2.87e-02 13 6 1 0.167 0.077 HP:0006721 hp 1 Acute lymphoblastic leukemia 1 P49917 218 2.87e-02 13 6 1 0.167 0.077 HP:0002572 hp 1 Episodic vomiting 1 P49917 218 2.87e-02 13 6 1 0.167 0.077 HP:0003075 hp 1 Hypoproteinemia 1 P49917 218 2.89e-02 505 6 2 0.333 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q7Z2E3,Q13426 218 2.93e-02 63 6 1 0.167 0.016 TF:M06224_0 tf 1 Factor: ZNF415; motif: NGGGTGAAAMGA; match class: 0 1 Q0D2I5 218 3.06e-02 10 6 1 0.167 0.100 GO:0016886 MF 1 ligase activity, forming phosphoric ester bonds 1 P49917 218 3.09e-02 14 6 1 0.167 0.071 HP:0000590 hp 1 Progressive external ophthalmoplegia 1 Q7Z2E3 218 3.17e-02 272 6 2 0.333 0.007 REAC:73894 rea 1 DNA Repair 1 Q13426,P49917 218 3.21e-02 69 6 1 0.167 0.014 TF:M06089_0 tf 1 Factor: ZNF26; motif: NAMTCAAGSGTA; match class: 0 1 Q7Z2E3 218 3.23e-02 1403 6 3 0.500 0.002 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.24e-02 537 6 2 0.333 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q7Z2E3,Q13426 218 3.26e-02 1408 6 3 0.500 0.002 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.31e-02 15 6 1 0.167 0.067 HP:0410005 hp 1 Cleft hard palate 1 P49917 218 3.31e-02 15 6 1 0.167 0.067 HP:0000176 hp 1 Submucous cleft hard palate 1 P49917 218 3.33e-02 1419 6 3 0.500 0.002 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q7Z2E3,Q13426,P49917 218 3.34e-02 2 6 1 0.167 0.500 OMIM:254500 omi 1 MYELOMA, MULTIPLEAMYLOIDOSIS, SYSTEMIC, INCLUDED; AL, INCLUDED;;AL AMYLOIDOSIS, INCLUDED 1 P49917 218 3.34e-02 2 6 1 0.167 0.500 CORUM:213 cor 1 DNA ligase IV-XRCC1 complex 1 P49917 218 3.37e-02 11 6 1 0.167 0.091 GO:0006273 BP 1 lagging strand elongation 1 P49917 218 3.41e-02 233 6 2 0.333 0.009 GO:0009314 BP 1 response to radiation 1 Q13426,P49917 218 3.48e-02 75 6 1 0.167 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 Q13426 218 3.53e-02 76 6 1 0.167 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q5TF58 218 3.54e-02 664 6 2 0.333 0.003 TF:M07358_0 tf 1 Factor: HSF2; motif: NGGAATNTTCTNGNRN; match class: 0 1 Q0D2I5,P49917 218 3.55e-02 1453 6 3 0.500 0.002 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.55e-02 564 6 2 0.333 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q7Z2E3,Q13426 218 3.59e-02 1459 6 3 0.500 0.002 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q7Z2E3,Q13426,P49917 218 3.61e-02 671 6 2 0.333 0.003 TF:M00531_1 tf 1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 1 1 Q0D2I5,Q5TF58 218 3.66e-02 1470 6 3 0.500 0.002 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.68e-02 12 6 1 0.167 0.083 GO:0008409 MF 1 5'-3' exonuclease activity 1 Q7Z2E3 218 3.73e-02 1480 6 3 0.500 0.002 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.74e-02 17 6 1 0.167 0.059 HP:0005387 hp 1 Combined immunodeficiency 1 P49917 218 3.75e-02 1748 6 3 0.500 0.002 TF:M07313_1 tf 1 Factor: ATF-3; motif: SNTGACGYNATN; match class: 1 1 Q7Z2E3,Q1L5Z9,P49917 218 3.79e-02 3189 6 4 0.667 0.001 TF:M04378_1 tf 1 Factor: IRX5; motif: NWACAYRACAWN; match class: 1 1 Q0D2I5,Q13426,Q5TF58,P49917 218 3.80e-02 82 6 1 0.167 0.012 TF:M04109_0 tf 1 Factor: RUNX3; motif: NRACCGCAAACCGCAN; match class: 0 1 Q5TF58 218 3.81e-02 1492 6 3 0.500 0.002 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q7Z2E3,Q13426,P49917 218 3.86e-02 1499 6 3 0.500 0.002 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.94e-02 596 6 2 0.333 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q7Z2E3,Q13426 218 3.95e-02 1513 6 3 0.500 0.002 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 3.96e-02 18 6 1 0.167 0.056 HP:0000547 hp 1 Tapetoretinal degeneration 1 P49917 218 3.96e-02 5054 6 5 0.833 0.001 TF:M01659_0 tf 1 Factor: Cdx-2; motif: BNNATAAANRN; match class: 0 1 Q0D2I5,Q7Z2E3,Q13426,Q5TF58,P49917 218 3.98e-02 13 6 1 0.167 0.077 GO:0002208 BP 1 somatic diversification of immunoglobulins involved in immune response 1 P49917 218 3.98e-02 13 6 1 0.167 0.077 GO:0045190 BP 1 isotype switching 1 P49917 218 3.98e-02 13 6 1 0.167 0.077 GO:0002204 BP 1 somatic recombination of immunoglobulin genes involved in immune response 1 P49917 218 4.01e-02 1521 6 3 0.500 0.002 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.03e-02 87 6 1 0.167 0.011 TF:M06603_0 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 0 1 Q13426 218 4.08e-02 88 6 1 0.167 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 Q13426 218 4.11e-02 1535 6 3 0.500 0.002 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.17e-02 90 6 1 0.167 0.011 TF:M06038_0 tf 1 Factor: TCF17; motif: NGKGGAAWAAKM; match class: 0 1 Q13426 218 4.17e-02 7496 6 6 1.000 0.001 TF:M01131_1 tf 1 Factor: SOX10; motif: CWTTGTN; match class: 1 1 Q0D2I5,Q7Z2E3,Q13426,Q5TF58,Q1L5Z9,P49917 218 4.17e-02 19 6 1 0.167 0.053 HP:0002720 hp 1 IgA deficiency 1 P49917 218 4.17e-02 19 6 1 0.167 0.053 HP:0010976 hp 1 B lymphocytopenia 1 P49917 218 4.18e-02 616 6 2 0.333 0.003 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 Q7Z2E3,Q13426 218 4.28e-02 1559 6 3 0.500 0.002 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.29e-02 14 6 1 0.167 0.071 GO:0004529 MF 1 exodeoxyribonuclease activity 1 Q7Z2E3 218 4.29e-02 14 6 1 0.167 0.071 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 P49917 218 4.29e-02 14 6 1 0.167 0.071 GO:0016447 BP 1 somatic recombination of immunoglobulin gene segments 1 P49917 218 4.29e-02 14 6 1 0.167 0.071 GO:0016895 MF 1 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1 Q7Z2E3 218 4.30e-02 625 6 2 0.333 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q7Z2E3,Q13426 218 4.30e-02 2805 6 4 0.667 0.001 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 Q7Z2E3,Q13426,Q5TF58,P49917 218 4.31e-02 93 6 1 0.167 0.011 TF:M06674_0 tf 1 Factor: znf587; motif: NGGGRCTGATGA; match class: 0 1 Q0D2I5 218 4.31e-02 93 6 1 0.167 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 Q13426 218 4.35e-02 94 6 1 0.167 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 Q13426 218 4.36e-02 5164 6 5 0.833 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q0D2I5,Q7Z2E3,Q13426,Q5TF58,Q1L5Z9 218 4.39e-02 20 6 1 0.167 0.050 HP:0410004 hp 1 Cleft secondary palate 1 P49917 218 4.39e-02 20 6 1 0.167 0.050 HP:0000640 hp 1 Gaze-evoked nystagmus 1 Q7Z2E3 218 4.39e-02 20 6 1 0.167 0.050 HP:0000778 hp 1 Hypoplasia of the thymus 1 P49917 218 4.39e-02 20 6 1 0.167 0.050 HP:0007676 hp 1 Hypoplasia of the iris 1 P49917 218 4.39e-02 1574 6 3 0.500 0.002 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.40e-02 95 6 1 0.167 0.011 TF:M05645_0 tf 1 Factor: ZNF736; motif: NGATGCTSCANA; match class: 0 1 Q1L5Z9 218 4.40e-02 1576 6 3 0.500 0.002 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.41e-02 634 6 2 0.333 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q7Z2E3,Q13426 218 4.44e-02 3338 6 4 0.667 0.001 TF:M07038_1 tf 1 Factor: DBP; motif: TTRCATAANN; match class: 1 1 Q13426,Q5TF58,Q1L5Z9,P49917 218 4.44e-02 96 6 1 0.167 0.010 TF:M05652_0 tf 1 Factor: ZFX; motif: KGGGGCTGCASC; match class: 0 1 Q0D2I5 218 4.44e-02 96 6 1 0.167 0.010 TF:M05649_0 tf 1 Factor: ZFY; motif: KGGGGCTGCAGC; match class: 0 1 Q0D2I5 218 4.47e-02 1868 6 3 0.500 0.002 TF:M01996_1 tf 1 Factor: AR; motif: GNNCNNNNTGTTCTN; match class: 1 1 Q7Z2E3,Q1L5Z9,P49917 218 4.50e-02 1589 6 3 0.500 0.002 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.58e-02 3368 6 4 0.667 0.001 TF:M00146_0 tf 1 Factor: HSF1; motif: AGAANRTTCN; match class: 0 1 Q0D2I5,Q7Z2E3,Q13426,Q5TF58 218 4.58e-02 1600 6 3 0.500 0.002 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q7Z2E3,Q13426,P49917 218 4.60e-02 21 6 1 0.167 0.048 HP:0002841 hp 1 Recurrent fungal infections 1 P49917 218 4.62e-02 650 6 2 0.333 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q7Z2E3,Q13426 218 4.62e-02 100 6 1 0.167 0.010 TF:M06551_0 tf 1 Factor: znf417; motif: NGGGRCTGATGA; match class: 0 1 Q0D2I5 218 4.69e-02 773 6 2 0.333 0.003 TF:M00294_1 tf 1 Factor: HFH8; motif: NNNTGTTTATNTR; match class: 1 1 Q7Z2E3,Q5TF58 218 4.73e-02 776 6 2 0.333 0.003 TF:M00984_0 tf 1 Factor: PEBP; motif: GNTNACCACARANNK; match class: 0 1 Q7Z2E3,Q13426 218 4.75e-02 1622 6 3 0.500 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q7Z2E3,Q13426,P49917 218 4.76e-02 103 6 1 0.167 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q13426 218 4.82e-02 22 6 1 0.167 0.045 HP:0001880 hp 1 Eosinophilia 1 P49917 218 4.82e-02 22 6 1 0.167 0.045 HP:0000829 hp 1 Hypoparathyroidism 1 P49917 218 4.82e-02 22 6 1 0.167 0.045 HP:0010975 hp 1 Abnormality of B cell number 1 P49917 218 4.82e-02 22 6 1 0.167 0.045 HP:0100646 hp 1 Thyroiditis 1 P49917 218 4.94e-02 674 6 2 0.333 0.003 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 Q7Z2E3,Q13426 218 5.00e-02 800 6 2 0.333 0.003 TF:M01864_1 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 1 1 Q7Z2E3,P49917 218 5.00e-02 922 6 3 0.500 0.003 GO:0003677 MF 1 DNA binding 1 Q7Z2E3,Q13426,P49917 218 5.00e-02 12 6 2 0.333 0.167 KEGG:03450 keg 1 Non-homologous end-joining 1 Q13426,P49917 218 5.00e-02 3 6 1 0.167 0.333 CORUM:353 cor 1 DNA ligase IV-condensin complex 1 P49917 218 5.00e-02 346 6 2 0.333 0.006 REAC:5663205 rea 1 Infectious disease 1 Q13426,P49917 218 5.00e-02 3 6 1 0.167 0.333 OMIM:208920 omi 1 Ataxia-Oculomotor Apraxia 1 Q7Z2E3 219 1.63e-08 17 3 3 1.000 0.176 REAC:418990 rea 1 Adherens junctions interactions 1 Q9Y6N8,P35221,P35222 219 7.84e-08 28 3 3 1.000 0.107 REAC:421270 rea 1 Cell-cell junction organization 1 Q9Y6N8,P35221,P35222 219 5.29e-07 52 3 3 1.000 0.058 REAC:446728 rea 1 Cell junction organization 1 Q9Y6N8,P35221,P35222 219 7.96e-07 73 3 3 1.000 0.041 GO:0034332 BP 1 adherens junction organization 1 Q9Y6N8,P35221,P35222 219 1.48e-06 5 3 2 0.667 0.400 GO:0071680 BP 1 response to indole-3-methanol 1 P35221,P35222 219 1.48e-06 5 3 2 0.667 0.400 GO:0071681 BP 1 cellular response to indole-3-methanol 1 P35221,P35222 219 3.10e-06 7 3 2 0.667 0.286 GO:0016342 CC 1 catenin complex 1 P35221,P35222 219 3.21e-06 94 3 3 1.000 0.032 REAC:1500931 rea 1 Cell-Cell communication 1 Q9Y6N8,P35221,P35222 219 3.97e-06 2 3 2 0.667 1.000 CORUM:4096 cor 1 Catenin (alpha) - catenin (beta) complex 1 P35221,P35222 219 4.80e-06 132 3 3 1.000 0.023 GO:0045216 BP 1 cell-cell junction organization 1 Q9Y6N8,P35221,P35222 219 7.77e-06 10 3 2 0.667 0.200 REAC:5626467 rea 1 RHO GTPases activate IQGAPs 1 P35221,P35222 219 7.95e-06 156 3 3 1.000 0.019 GO:0034330 BP 1 cell junction organization 1 Q9Y6N8,P35221,P35222 219 1.15e-05 13 3 2 0.667 0.154 GO:0097306 BP 1 cellular response to alcohol 1 P35221,P35222 219 3.98e-05 22 3 2 0.667 0.091 REAC:525793 rea 1 Myogenesis 1 P35221,P35222 219 3.98e-05 22 3 2 0.667 0.091 REAC:375170 rea 1 CDO in myogenesis 1 P35221,P35222 219 4.76e-05 24 3 2 0.667 0.083 REAC:5218920 rea 1 VEGFR2 mediated vascular permeability 1 P35221,P35222 219 5.99e-05 29 3 2 0.667 0.069 GO:0097305 BP 1 response to alcohol 1 P35221,P35222 219 9.82e-05 37 3 2 0.667 0.054 GO:0051149 BP 1 positive regulation of muscle cell differentiation 1 P35221,P35222 219 3.87e-04 73 3 2 0.667 0.027 GO:0051147 BP 1 regulation of muscle cell differentiation 1 P35221,P35222 219 6.29e-04 49 3 2 0.667 0.041 KEGG:05213 keg 1 Endometrial cancer 1 P35221,P35222 219 6.62e-04 678 3 3 1.000 0.004 GO:0007155 BP 1 cell adhesion 1 Q9Y6N8,P35221,P35222 219 6.80e-04 684 3 3 1.000 0.004 GO:0022610 BP 1 biological adhesion 1 Q9Y6N8,P35221,P35222 219 6.98e-04 98 3 2 0.667 0.020 GO:0019897 CC 1 extrinsic component of plasma membrane 1 P35221,P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:0036023 BP 1 embryonic skeletal limb joint morphogenesis 1 P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:1901963 BP 1 regulation of cell proliferation involved in outflow tract morphogenesis 1 P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:0036022 BP 1 limb joint morphogenesis 1 P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:1990188 MF 1 euchromatin binding 1 P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:0044336 BP 1 canonical Wnt signaling pathway involved in negative regulation of apoptotic process 1 P35222 219 8.52e-04 1 3 1 0.333 1.000 GO:0061324 BP 1 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation 1 P35222 219 1.04e-03 63 3 2 0.667 0.032 KEGG:05412 keg 1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1 P35221,P35222 219 1.14e-03 125 3 2 0.667 0.016 GO:0098797 CC 1 plasma membrane protein complex 1 P35221,P35222 219 1.17e-03 127 3 2 0.667 0.016 GO:0034329 BP 1 cell junction assembly 1 P35221,P35222 219 1.29e-03 70 3 2 0.667 0.029 KEGG:04520 keg 1 Adherens junction 1 P35221,P35222 219 1.40e-03 73 3 2 0.667 0.027 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 P35221,P35222 219 1.41e-03 139 3 2 0.667 0.014 GO:0042692 BP 1 muscle cell differentiation 1 P35221,P35222 219 1.52e-03 76 3 2 0.667 0.026 KEGG:04670 keg 1 Leukocyte transendothelial migration 1 P35221,P35222 219 1.70e-03 2 3 1 0.333 0.500 GO:0045976 BP 1 negative regulation of mitotic cell cycle, embryonic 1 P35222 219 1.70e-03 2 3 1 0.333 0.500 GO:0070369 CC 1 beta-catenin-TCF7L2 complex 1 P35222 219 1.70e-03 2 3 1 0.333 0.500 GO:0061325 BP 1 cell proliferation involved in outflow tract morphogenesis 1 P35222 219 1.70e-03 2 3 1 0.333 0.500 GO:0044334 BP 1 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 1 P35222 219 1.74e-03 1 3 1 0.333 1.000 OMIM:132600 omi 1 PILOMATRIXOMA;;PILOMATRICOMA; PTR;;EPITHELIOMA CALCIFICANS OF MALHERBE 1 P35222 219 1.74e-03 1 3 1 0.333 1.000 OMIM:615075 omi 1 MENTAL RETARDATION, AUTOSOMAL DOMINANT 19; MRD19 1 P35222 219 2.25e-03 176 3 2 0.667 0.011 GO:0019898 CC 1 extrinsic component of membrane 1 P35221,P35222 219 2.50e-03 4 3 1 0.333 0.250 REAC:3134973 rea 1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0045448 BP 1 mitotic cell cycle, embryonic 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:1990907 CC 1 beta-catenin-TCF complex 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:1902730 BP 1 positive regulation of proteoglycan biosynthetic process 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0010908 BP 1 regulation of heparan sulfate proteoglycan biosynthetic process 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0071664 CC 1 catenin-TCF7L2 complex 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0009794 BP 1 regulation of mitotic cell cycle, embryonic 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:1904954 BP 1 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0010909 BP 1 positive regulation of heparan sulfate proteoglycan biosynthetic process 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0070602 BP 1 regulation of centromeric sister chromatid cohesion 1 P35222 219 2.55e-03 3 3 1 0.333 0.333 GO:0030997 BP 1 regulation of centriole-centriole cohesion 1 P35222 219 3.24e-03 111 3 2 0.667 0.018 KEGG:04530 keg 1 Tight junction 1 P35221,P35222 219 3.41e-03 4 3 1 0.333 0.250 GO:0003306 BP 1 Wnt signaling pathway involved in heart development 1 P35222 219 3.41e-03 4 3 1 0.333 0.250 GO:0051176 BP 1 positive regulation of sulfur metabolic process 1 P35222 219 3.41e-03 4 3 1 0.333 0.250 GO:0061316 BP 1 canonical Wnt signaling pathway involved in heart development 1 P35222 219 3.41e-03 4 3 1 0.333 0.250 GO:0060272 BP 1 embryonic skeletal joint morphogenesis 1 P35222 219 3.41e-03 4 3 1 0.333 0.250 GO:0072498 BP 1 embryonic skeletal joint development 1 P35222 219 3.42e-03 217 3 2 0.667 0.009 GO:0061061 BP 1 muscle structure development 1 P35221,P35222 219 3.74e-03 6 3 1 0.333 0.167 REAC:4411364 rea 1 Binding of TCF/LEF:CTNNB1 to target gene promoters 1 P35222 219 4.26e-03 5 3 1 0.333 0.200 GO:2000136 BP 1 regulation of cell proliferation involved in heart morphogenesis 1 P35222 219 4.26e-03 5 3 1 0.333 0.200 GO:0044340 BP 1 canonical Wnt signaling pathway involved in regulation of cell proliferation 1 P35222 219 4.26e-03 5 3 1 0.333 0.200 GO:0072182 BP 1 regulation of nephron tubule epithelial cell differentiation 1 P35222 219 4.30e-03 128 3 2 0.667 0.016 KEGG:04390 keg 1 Hippo signaling pathway 1 P35221,P35222 219 4.35e-03 245 3 2 0.667 0.008 GO:0071407 BP 1 cellular response to organic cyclic compound 1 P35221,P35222 219 4.49e-03 231 3 2 0.667 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 P35221,P35222 219 4.90e-03 260 3 2 0.667 0.008 GO:0071417 BP 1 cellular response to organonitrogen compound 1 P35221,P35222 219 5.11e-03 6 3 1 0.333 0.167 GO:0033234 BP 1 negative regulation of protein sumoylation 1 P35222 219 5.11e-03 6 3 1 0.333 0.167 GO:0070601 BP 1 centromeric sister chromatid cohesion 1 P35222 219 5.32e-03 271 3 2 0.667 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 P35221,P35222 219 5.48e-03 275 3 2 0.667 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 P35221,P35222 219 5.56e-03 277 3 2 0.667 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 P35221,P35222 219 5.76e-03 282 3 2 0.667 0.007 GO:0045296 MF 1 cadherin binding 1 P35221,P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:2000696 BP 1 regulation of epithelial cell differentiation involved in kidney development 1 P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:0061323 BP 1 cell proliferation involved in heart morphogenesis 1 P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:0002052 BP 1 positive regulation of neuroblast proliferation 1 P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:0061549 BP 1 sympathetic ganglion development 1 P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:0072160 BP 1 nephron tubule epithelial cell differentiation 1 P35222 219 5.96e-03 7 3 1 0.333 0.143 GO:0045294 MF 1 alpha-catenin binding 1 P35222 219 6.21e-03 272 3 2 0.667 0.007 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 P35221,P35222 219 6.23e-03 10 3 1 0.333 0.100 REAC:351906 rea 1 Apoptotic cleavage of cell adhesion proteins 1 P35222 219 6.25e-03 294 3 2 0.667 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 P35221,P35222 219 6.33e-03 523 3 2 0.667 0.004 MI:hsa-miR-582-3p mi 1 MI:hsa-miR-582-3p 1 Q9Y6N8,P35222 219 6.48e-03 278 3 2 0.667 0.007 REAC:194138 rea 1 Signaling by VEGF 1 P35221,P35222 219 6.81e-03 8 3 1 0.333 0.125 GO:0070411 MF 1 I-SMAD binding 1 P35222 219 6.81e-03 8 3 1 0.333 0.125 GO:0010560 BP 1 positive regulation of glycoprotein biosynthetic process 1 P35222 219 6.81e-03 8 3 1 0.333 0.125 GO:0061548 BP 1 ganglion development 1 P35222 219 6.81e-03 307 3 2 0.667 0.007 GO:0010243 BP 1 response to organonitrogen compound 1 P35221,P35222 219 6.90e-03 309 3 2 0.667 0.006 GO:0014070 BP 1 response to organic cyclic compound 1 P35221,P35222 219 7.17e-03 315 3 2 0.667 0.006 GO:1901699 BP 1 cellular response to nitrogen compound 1 P35221,P35222 219 7.66e-03 9 3 1 0.333 0.111 GO:1990909 CC 1 Wnt signalosome 1 P35222 219 7.66e-03 9 3 1 0.333 0.111 GO:1902692 BP 1 regulation of neuroblast proliferation 1 P35222 219 8.01e-03 333 3 2 0.667 0.006 GO:0005925 CC 1 focal adhesion 1 P35221,P35222 219 8.01e-03 333 3 2 0.667 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 P35221,P35222 219 8.06e-03 334 3 2 0.667 0.006 GO:0016337 BP 1 single organismal cell-cell adhesion 1 Q9Y6N8,P35222 219 8.10e-03 13 3 1 0.333 0.077 REAC:4641265 rea 1 Repression of WNT target genes 1 P35222 219 8.20e-03 337 3 2 0.667 0.006 GO:0030055 CC 1 cell-substrate junction 1 P35221,P35222 219 8.51e-03 10 3 1 0.333 0.100 GO:2000648 BP 1 positive regulation of stem cell proliferation 1 P35222 219 8.51e-03 10 3 1 0.333 0.100 GO:0045295 MF 1 gamma-catenin binding 1 P35221 219 8.51e-03 10 3 1 0.333 0.100 GO:0017166 MF 1 vinculin binding 1 P35221 219 8.51e-03 10 3 1 0.333 0.100 GO:1903020 BP 1 positive regulation of glycoprotein metabolic process 1 P35222 219 8.51e-03 10 3 1 0.333 0.100 GO:0010457 BP 1 centriole-centriole cohesion 1 P35222 219 8.72e-03 14 3 1 0.333 0.071 REAC:381771 rea 1 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 1 P35222 219 9.13e-03 2 3 1 0.333 0.500 CORUM:4095 cor 1 Catulin (alpha) - catenin (beta) complex 1 P35222 219 9.13e-03 2 3 1 0.333 0.500 CORUM:5262 cor 1 TCF4-CTNNB1 complex 1 P35222 219 9.13e-03 2 3 1 0.333 0.500 CORUM:826 cor 1 PAR-3-VE-cadherin-beta-catenin complex 1 P35222 219 9.13e-03 2 3 1 0.333 0.500 CORUM:5274 cor 1 Cell-cell junction complex (ARHGAP10-CTNNA1) 1 P35221 219 9.13e-03 2 3 1 0.333 0.500 CORUM:3155 cor 1 Bipartite complex (TFC4, CTNNB1) 1 P35222 219 9.13e-03 2 3 1 0.333 0.500 CORUM:5281 cor 1 Cell-cell junction complex (CDH1-CTNNB1) 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:5358747 rea 1 S33 mutants of beta-catenin aren't phosphorylated 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:5358749 rea 1 S37 mutants of beta-catenin aren't phosphorylated 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:5358752 rea 1 T41 mutants of beta-catenin aren't phosphorylated 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:5339716 rea 1 Misspliced GSK3beta mutants stabilize beta-catenin 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:5358751 rea 1 S45 mutants of beta-catenin aren't phosphorylated 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:4839743 rea 1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1 P35222 219 9.34e-03 15 3 1 0.333 0.067 REAC:400508 rea 1 Incretin synthesis, secretion, and inactivation 1 P35222 219 9.36e-03 11 3 1 0.333 0.091 GO:1904953 BP 1 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 1 P35222 219 9.36e-03 11 3 1 0.333 0.091 GO:0048485 BP 1 sympathetic nervous system development 1 P35222 219 9.36e-03 11 3 1 0.333 0.091 GO:0035315 BP 1 hair cell differentiation 1 P35222 219 9.36e-03 11 3 1 0.333 0.091 GO:0061154 BP 1 endothelial tube morphogenesis 1 P35222 219 9.36e-03 11 3 1 0.333 0.091 GO:0001569 BP 1 branching involved in blood vessel morphogenesis 1 P35222 219 9.54e-03 338 3 2 0.667 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 P35221,P35222 219 9.81e-03 369 3 2 0.667 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 P35221,P35222 219 9.87e-03 370 3 2 0.667 0.005 GO:0098602 BP 1 single organism cell adhesion 1 Q9Y6N8,P35222 219 9.97e-03 372 3 2 0.667 0.005 GO:0045597 BP 1 positive regulation of cell differentiation 1 P35221,P35222 219 1.02e-02 12 3 1 0.333 0.083 GO:1904948 BP 1 midbrain dopaminergic neuron differentiation 1 P35222 219 1.02e-02 12 3 1 0.333 0.083 GO:0045992 BP 1 negative regulation of embryonic development 1 P35222 219 1.03e-02 378 3 2 0.667 0.005 GO:1901698 BP 1 response to nitrogen compound 1 P35221,P35222 219 1.04e-02 6 3 1 0.333 0.167 OMIM:167000 omi 1 OVARIAN CANCEROVARIAN CANCER, EPITHELIAL, INCLUDED 1 P35222 219 1.06e-02 17 3 1 0.333 0.059 REAC:196299 rea 1 Beta-catenin phosphorylation cascade 1 P35222 219 1.09e-02 389 3 2 0.667 0.005 GO:0098609 BP 1 cell-cell adhesion 1 Q9Y6N8,P35222 219 1.11e-02 13 3 1 0.333 0.077 GO:0003159 BP 1 morphogenesis of an endothelium 1 P35222 219 1.11e-02 13 3 1 0.333 0.077 GO:0030877 CC 1 beta-catenin destruction complex 1 P35222 219 1.11e-02 13 3 1 0.333 0.077 GO:2000179 BP 1 positive regulation of neural precursor cell proliferation 1 P35222 219 1.11e-02 13 3 1 0.333 0.077 GO:0051571 BP 1 positive regulation of histone H3-K4 methylation 1 P35222 219 1.19e-02 14 3 1 0.333 0.071 GO:0005719 CC 1 nuclear euchromatin 1 P35222 219 1.27e-02 420 3 2 0.667 0.005 GO:0005911 CC 1 cell-cell junction 1 P35221,P35222 219 1.28e-02 15 3 1 0.333 0.067 GO:2000826 BP 1 regulation of heart morphogenesis 1 P35222 219 1.28e-02 15 3 1 0.333 0.067 GO:0048483 BP 1 autonomic nervous system development 1 P35222 219 1.28e-02 15 3 1 0.333 0.067 GO:2000144 BP 1 positive regulation of DNA-templated transcription, initiation 1 P35222 219 1.28e-02 15 3 1 0.333 0.067 GO:0015012 BP 1 heparan sulfate proteoglycan biosynthetic process 1 P35222 219 1.36e-02 16 3 1 0.333 0.062 GO:0043525 BP 1 positive regulation of neuron apoptotic process 1 P35222 219 1.36e-02 16 3 1 0.333 0.062 GO:0033233 BP 1 regulation of protein sumoylation 1 P35222 219 1.36e-02 16 3 1 0.333 0.062 GO:0061311 BP 1 cell surface receptor signaling pathway involved in heart development 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:3004 cor 1 APC-Axin-1-beta-catenin complex 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:5772 cor 1 ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:5261 cor 1 TCF4-CTNNB1-EP300 complex 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:1816 cor 1 JUN-TCF4-CTNNB1 complex 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:521 cor 1 Polycystin-1-E-cadherin-beta-catenin complex 1 P35222 219 1.37e-02 3 3 1 0.333 0.333 CORUM:5264 cor 1 TCF4-CTNNB1-CREBBP complex 1 P35222 219 1.39e-02 8 3 1 0.333 0.125 OMIM:114550 omi 1 HEPATOCELLULAR CARCINOMA;;HCC;;CANCER, HEPATOCELLULAR;;LIVER CANCER;;LIVER CELL CARCINOMA; LCC;;HEPATOMAHEPATOBLASTOMA, INCLUDED;;HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION, INCLUDED 1 P35222 219 1.42e-02 444 3 2 0.667 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P35221,P35222 219 1.42e-02 444 3 2 0.667 0.005 GO:0098796 CC 1 membrane protein complex 1 P35221,P35222 219 1.45e-02 17 3 1 0.333 0.059 GO:0051569 BP 1 regulation of histone H3-K4 methylation 1 P35222 219 1.45e-02 17 3 1 0.333 0.059 GO:0035411 BP 1 catenin import into nucleus 1 P35222 219 1.45e-02 17 3 1 0.333 0.059 GO:0032355 BP 1 response to estradiol 1 P35222 219 1.45e-02 17 3 1 0.333 0.059 GO:0000791 CC 1 euchromatin 1 P35222 219 1.45e-02 17 3 1 0.333 0.059 GO:0042762 BP 1 regulation of sulfur metabolic process 1 P35222 219 1.53e-02 18 3 1 0.333 0.056 GO:0072091 BP 1 regulation of stem cell proliferation 1 P35222 219 1.53e-02 18 3 1 0.333 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 P35222 219 1.53e-02 18 3 1 0.333 0.056 GO:0007063 BP 1 regulation of sister chromatid cohesion 1 P35222 219 1.62e-02 19 3 1 0.333 0.053 GO:2000142 BP 1 regulation of DNA-templated transcription, initiation 1 P35222 219 1.68e-02 27 3 1 0.333 0.037 REAC:4791275 rea 1 Signaling by WNT in cancer 1 P35222 219 1.70e-02 20 3 1 0.333 0.050 GO:1904886 BP 1 beta-catenin destruction complex disassembly 1 P35222 219 1.70e-02 20 3 1 0.333 0.050 GO:0071542 BP 1 dopaminergic neuron differentiation 1 P35222 219 1.70e-02 20 3 1 0.333 0.050 GO:0048704 BP 1 embryonic skeletal system morphogenesis 1 P35222 219 1.79e-02 21 3 1 0.333 0.048 GO:0010559 BP 1 regulation of glycoprotein biosynthetic process 1 P35222 219 1.79e-02 21 3 1 0.333 0.048 GO:0030201 BP 1 heparan sulfate proteoglycan metabolic process 1 P35222 219 1.80e-02 501 3 2 0.667 0.004 GO:0051094 BP 1 positive regulation of developmental process 1 P35221,P35222 219 1.80e-02 29 3 1 0.333 0.034 REAC:4641262 rea 1 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 P35222 219 1.82e-02 4 3 1 0.333 0.250 CORUM:3166 cor 1 AXIN-APC-betaCatenin-GSK3B complex 1 P35222 219 1.82e-02 4 3 1 0.333 0.250 CORUM:522 cor 1 Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex 1 P35222 219 1.82e-02 4 3 1 0.333 0.250 CORUM:2998 cor 1 Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex 1 P35222 219 1.87e-02 22 3 1 0.333 0.045 GO:0090183 BP 1 regulation of kidney development 1 P35222 219 1.87e-02 22 3 1 0.333 0.045 GO:0035850 BP 1 epithelial cell differentiation involved in kidney development 1 P35222 219 1.87e-02 22 3 1 0.333 0.045 GO:2000177 BP 1 regulation of neural precursor cell proliferation 1 P35222 219 1.87e-02 22 3 1 0.333 0.045 GO:0007405 BP 1 neuroblast proliferation 1 P35222 219 1.87e-02 22 3 1 0.333 0.045 GO:0030331 MF 1 estrogen receptor binding 1 P35222 219 1.96e-02 23 3 1 0.333 0.043 GO:0061005 BP 1 cell differentiation involved in kidney development 1 P35222 219 1.96e-02 23 3 1 0.333 0.043 GO:0031062 BP 1 positive regulation of histone methylation 1 P35222 219 1.96e-02 23 3 1 0.333 0.043 GO:0016328 CC 1 lateral plasma membrane 1 P35222 219 2.04e-02 24 3 1 0.333 0.042 GO:0072080 BP 1 nephron tubule development 1 P35222 219 2.04e-02 24 3 1 0.333 0.042 GO:1901216 BP 1 positive regulation of neuron death 1 P35222 219 2.12e-02 25 3 1 0.333 0.040 GO:1903018 BP 1 regulation of glycoprotein metabolic process 1 P35222 219 2.12e-02 25 3 1 0.333 0.040 GO:0061326 BP 1 renal tubule development 1 P35222 219 2.12e-02 25 3 1 0.333 0.040 GO:0030326 BP 1 embryonic limb morphogenesis 1 P35222 219 2.12e-02 25 3 1 0.333 0.040 GO:0035113 BP 1 embryonic appendage morphogenesis 1 P35222 219 2.12e-02 25 3 1 0.333 0.040 GO:0001102 MF 1 RNA polymerase II activating transcription factor binding 1 P35222 219 2.14e-02 9 3 1 0.333 0.111 TF:M04215_1 tf 1 Factor: MAFF; motif: NTGCTGASTCAGCAW; match class: 1 1 Q9Y6N8 219 2.14e-02 9 3 1 0.333 0.111 TF:M06309_0 tf 1 Factor: ZNF678; motif: KGGTAAGAAASA; match class: 0 1 P35222 219 2.17e-02 35 3 1 0.333 0.029 REAC:3769402 rea 1 Deactivation of the beta-catenin transactivating complex 1 P35222 219 2.28e-02 5 3 1 0.333 0.200 CORUM:5260 cor 1 TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex 1 P35222 219 2.29e-02 27 3 1 0.333 0.037 GO:0048706 BP 1 embryonic skeletal system development 1 P35222 219 2.30e-02 37 3 1 0.333 0.027 REAC:111465 rea 1 Apoptotic cleavage of cellular proteins 1 P35222 219 2.38e-02 28 3 1 0.333 0.036 GO:1904837 BP 1 beta-catenin-TCF complex assembly 1 P35222 219 2.38e-02 28 3 1 0.333 0.036 GO:0010718 BP 1 positive regulation of epithelial to mesenchymal transition 1 P35222 219 2.41e-02 582 3 2 0.667 0.003 GO:0005912 CC 1 adherens junction 1 P35221,P35222 219 2.45e-02 586 3 2 0.667 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 P35221,P35222 219 2.49e-02 591 3 2 0.667 0.003 GO:0070161 CC 1 anchoring junction 1 P35221,P35222 219 2.55e-02 30 3 1 0.333 0.033 GO:0035107 BP 1 appendage morphogenesis 1 P35222 219 2.55e-02 30 3 1 0.333 0.033 GO:0035108 BP 1 limb morphogenesis 1 P35222 219 2.55e-02 30 3 1 0.333 0.033 GO:0007223 BP 1 Wnt signaling pathway, calcium modulating pathway 1 P35222 219 2.71e-02 325 3 2 0.667 0.006 KEGG:05200 keg 1 Pathways in cancer 1 P35221,P35222 219 2.72e-02 32 3 1 0.333 0.031 GO:0003151 BP 1 outflow tract morphogenesis 1 P35222 219 2.73e-02 44 3 1 0.333 0.023 REAC:201722 rea 1 Formation of the beta-catenin:TCF transactivating complex 1 P35222 219 2.75e-02 1 3 1 0.333 1.000 HP:0030434 hp 1 Pilomatrixoma 1 P35222 219 2.80e-02 33 3 1 0.333 0.030 GO:0034394 BP 1 protein localization to cell surface 1 P35222 219 2.80e-02 33 3 1 0.333 0.030 GO:0051568 BP 1 histone H3-K4 methylation 1 P35222 219 2.89e-02 34 3 1 0.333 0.029 GO:0072009 BP 1 nephron epithelium development 1 P35222 219 2.89e-02 34 3 1 0.333 0.029 GO:0031060 BP 1 regulation of histone methylation 1 P35222 219 2.94e-02 643 3 2 0.667 0.003 GO:0071495 BP 1 cellular response to endogenous stimulus 1 P35221,P35222 219 2.97e-02 35 3 1 0.333 0.029 GO:0050681 MF 1 androgen receptor binding 1 P35222 219 2.97e-02 35 3 1 0.333 0.029 GO:0048660 BP 1 regulation of smooth muscle cell proliferation 1 P35222 219 3.02e-02 2420 3 3 1.000 0.001 GO:0005886 CC 1 plasma membrane 1 Q9Y6N8,P35221,P35222 219 3.06e-02 36 3 1 0.333 0.028 GO:0048754 BP 1 branching morphogenesis of an epithelial tube 1 P35222 219 3.14e-02 37 3 1 0.333 0.027 GO:0043297 BP 1 apical junction assembly 1 P35221 219 3.14e-02 37 3 1 0.333 0.027 GO:0048659 BP 1 smooth muscle cell proliferation 1 P35222 219 3.14e-02 37 3 1 0.333 0.027 GO:0048145 BP 1 regulation of fibroblast proliferation 1 P35222 219 3.14e-02 37 3 1 0.333 0.027 GO:0033613 MF 1 activating transcription factor binding 1 P35222 219 3.16e-02 51 3 1 0.333 0.020 REAC:4086398 rea 1 Ca2+ pathway 1 P35222 219 3.16e-02 51 3 1 0.333 0.020 REAC:75153 rea 1 Apoptotic execution phase 1 P35222 219 3.21e-02 2469 3 3 1.000 0.001 GO:0071944 CC 1 cell periphery 1 Q9Y6N8,P35221,P35222 219 3.23e-02 38 3 1 0.333 0.026 GO:0048144 BP 1 fibroblast proliferation 1 P35222 219 3.31e-02 39 3 1 0.333 0.026 GO:0061138 BP 1 morphogenesis of a branching epithelium 1 P35222 219 3.33e-02 1894 3 3 1.000 0.002 TF:M04385_0 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 0 1 Q9Y6N8,P35221,P35222 219 3.40e-02 40 3 1 0.333 0.025 GO:0072073 BP 1 kidney epithelium development 1 P35222 219 3.40e-02 40 3 1 0.333 0.025 GO:0048736 BP 1 appendage development 1 P35222 219 3.40e-02 40 3 1 0.333 0.025 GO:0060173 BP 1 limb development 1 P35222 219 3.47e-02 700 3 2 0.667 0.003 GO:0045595 BP 1 regulation of cell differentiation 1 P35221,P35222 219 3.56e-02 42 3 1 0.333 0.024 GO:0030856 BP 1 regulation of epithelial cell differentiation 1 P35222 219 3.56e-02 42 3 1 0.333 0.024 GO:0048705 BP 1 skeletal system morphogenesis 1 P35222 219 3.56e-02 42 3 1 0.333 0.024 GO:0030166 BP 1 proteoglycan biosynthetic process 1 P35222 219 3.58e-02 712 3 2 0.667 0.003 GO:0009719 BP 1 response to endogenous stimulus 1 P35221,P35222 219 3.65e-02 43 3 1 0.333 0.023 GO:0090279 BP 1 regulation of calcium ion import 1 P35222 219 3.65e-02 59 3 1 0.333 0.017 REAC:2980736 rea 1 Peptide hormone metabolism 1 P35222 219 3.66e-02 27 3 1 0.333 0.037 KEGG:05216 keg 1 Thyroid cancer 1 P35222 219 3.71e-02 60 3 1 0.333 0.017 REAC:1834949 rea 1 Cytosolic sensors of pathogen-associated DNA 1 P35222 219 3.73e-02 44 3 1 0.333 0.023 GO:0061351 BP 1 neural precursor cell proliferation 1 P35222 219 3.73e-02 44 3 1 0.333 0.023 GO:0046332 MF 1 SMAD binding 1 P35222 219 3.82e-02 45 3 1 0.333 0.022 GO:0072089 BP 1 stem cell proliferation 1 P35222 219 3.82e-02 45 3 1 0.333 0.022 GO:0001763 BP 1 morphogenesis of a branching structure 1 P35222 219 3.93e-02 746 3 2 0.667 0.003 GO:0030054 CC 1 cell junction 1 P35221,P35222 219 4.15e-02 718 3 2 0.667 0.003 REAC:1266738 rea 1 Developmental Biology 1 P35221,P35222 219 4.16e-02 49 3 1 0.333 0.020 GO:0045995 BP 1 regulation of embryonic development 1 P35222 219 4.24e-02 50 3 1 0.333 0.020 GO:0032481 BP 1 positive regulation of type I interferon production 1 P35222 219 4.29e-02 18 3 1 0.333 0.056 TF:M04215_0 tf 1 Factor: MAFF; motif: NTGCTGASTCAGCAW; match class: 0 1 Q9Y6N8 219 4.29e-02 18 3 1 0.333 0.056 TF:M06061_0 tf 1 Factor: ZNF253; motif: NGGGTAAAAATM; match class: 0 1 Q9Y6N8 219 4.33e-02 51 3 1 0.333 0.020 GO:0072006 BP 1 nephron development 1 P35222 219 4.33e-02 51 3 1 0.333 0.020 GO:0010717 BP 1 regulation of epithelial to mesenchymal transition 1 P35222 219 4.33e-02 51 3 1 0.333 0.020 GO:0030901 BP 1 midbrain development 1 P35222 219 4.33e-02 51 3 1 0.333 0.020 GO:0021953 BP 1 central nervous system neuron differentiation 1 P35222 219 4.41e-02 52 3 1 0.333 0.019 GO:0034333 BP 1 adherens junction assembly 1 P35222 219 4.41e-02 52 3 1 0.333 0.019 GO:0031058 BP 1 positive regulation of histone modification 1 P35222 219 4.49e-02 53 3 1 0.333 0.019 GO:0033045 BP 1 regulation of sister chromatid segregation 1 P35222 219 4.49e-02 53 3 1 0.333 0.019 GO:0035258 MF 1 steroid hormone receptor binding 1 P35222 219 4.49e-02 53 3 1 0.333 0.019 GO:0030521 BP 1 androgen receptor signaling pathway 1 P35222 219 4.66e-02 55 3 1 0.333 0.018 GO:0006029 BP 1 proteoglycan metabolic process 1 P35222 219 4.66e-02 55 3 1 0.333 0.018 GO:0007043 BP 1 cell-cell junction assembly 1 P35221 219 4.75e-02 56 3 1 0.333 0.018 GO:0008013 MF 1 beta-catenin binding 1 P35221 219 4.75e-02 56 3 1 0.333 0.018 GO:0034968 BP 1 histone lysine methylation 1 P35222 219 4.75e-02 56 3 1 0.333 0.018 GO:0033002 BP 1 muscle cell proliferation 1 P35222 219 4.83e-02 57 3 1 0.333 0.018 GO:1905269 BP 1 positive regulation of chromatin organization 1 P35222 219 4.89e-02 2153 3 3 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 Q9Y6N8,P35221,P35222 219 4.89e-02 2153 3 3 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 Q9Y6N8,P35221,P35222 219 4.92e-02 58 3 1 0.333 0.017 GO:0009913 BP 1 epidermal cell differentiation 1 P35222 219 5.00e-02 81 3 1 0.333 0.012 REAC:195253 rea 1 Degradation of beta-catenin by the destruction complex 1 P35222 219 5.00e-02 161 3 2 0.667 0.012 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 P35221,P35222 219 5.00e-02 71 3 2 0.667 0.028 HP:0006753 hp 1 Neoplasm of the stomach 1 P35221,P35222 219 5.00e-02 29 3 1 0.333 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 P35222 219 5.00e-02 59 3 1 0.333 0.017 GO:0019827 BP 1 stem cell population maintenance 1 P35222 219 5.00e-02 11 3 1 0.333 0.091 CORUM:5177 cor 1 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 1 P35222 219 5.00e-02 37 3 1 0.333 0.027 KEGG:05217 keg 1 Basal cell carcinoma 1 P35222 219 5.00e-02 59 3 1 0.333 0.017 GO:0098727 BP 1 maintenance of cell number 1 P35222 219 5.00e-02 21 3 1 0.333 0.048 TF:M05517_0 tf 1 Factor: HELIOS; motif: AACTGAACGAATC; match class: 0 1 P35222 220 2.22e-30 11 11 10 0.909 0.909 REAC:2408517 rea 1 SeMet incorporation into proteins 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.96e-25 24 11 10 0.909 0.417 REAC:379716 rea 1 Cytosolic tRNA aminoacylation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.90e-23 47 11 10 0.909 0.213 GO:0006418 BP 1 tRNA aminoacylation for protein translation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 5.75e-23 50 11 10 0.909 0.200 GO:0043038 BP 1 amino acid activation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 5.75e-23 50 11 10 0.909 0.200 GO:0043039 BP 1 tRNA aminoacylation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.96e-22 42 11 10 0.909 0.238 REAC:379724 rea 1 tRNA Aminoacylation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 6.06e-18 149 11 10 0.909 0.067 GO:0006399 BP 1 tRNA metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.49e-17 115 11 10 0.909 0.087 REAC:2408522 rea 1 Selenoamino acid metabolism 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.25e-15 283 11 10 0.909 0.035 GO:0006520 BP 1 cellular amino acid metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 9.57e-15 42 11 7 0.636 0.167 GO:0016876 MF 1 ligase activity, forming aminoacyl-tRNA and related compounds 1 Q15046,P54136,P14868,Q9P2J5,P56192,P47897,P41252 220 9.57e-15 42 11 7 0.636 0.167 GO:0016875 MF 1 ligase activity, forming carbon-oxygen bonds 1 Q15046,P54136,P14868,Q9P2J5,P56192,P47897,P41252 220 9.57e-15 42 11 7 0.636 0.167 GO:0004812 MF 1 aminoacyl-tRNA ligase activity 1 Q15046,P54136,P14868,Q9P2J5,P56192,P47897,P41252 220 5.75e-13 323 11 10 0.909 0.031 REAC:71291 rea 1 Metabolism of amino acids and derivatives 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 9.38e-13 483 11 10 0.909 0.021 GO:0006412 BP 1 translation 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.07e-12 44 11 7 0.636 0.159 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 Q15046,P54136,P14868,Q9P2J5,P56192,P47897,P41252 220 1.13e-12 492 11 10 0.909 0.020 GO:0034660 BP 1 ncRNA metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.28e-12 498 11 10 0.909 0.020 GO:0043043 BP 1 peptide biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.39e-12 549 11 10 0.909 0.018 GO:0043604 BP 1 amide biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 7.23e-12 592 11 10 0.909 0.017 GO:0006518 BP 1 peptide metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.85e-11 650 11 10 0.909 0.015 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.22e-11 706 11 10 0.909 0.014 GO:0043603 BP 1 cellular amide metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.29e-11 133 11 7 0.636 0.053 GO:0016874 MF 1 ligase activity 1 Q15046,P54136,P14868,Q9P2J5,P56192,P47897,P41252 220 5.82e-11 729 11 10 0.909 0.014 GO:0043436 BP 1 oxoacid metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 6.67e-11 739 11 10 0.909 0.014 GO:0006082 BP 1 organic acid metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 9.57e-10 965 11 10 0.909 0.010 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.37e-08 1333 11 10 0.909 0.008 GO:0044281 BP 1 small molecule metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.16e-07 1565 11 10 0.909 0.006 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.70e-07 2560 11 11 1.000 0.004 GO:0044710 BP 1 single-organism metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 6.84e-07 2707 11 11 1.000 0.004 GO:0005829 CC 1 cytosol 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.05e-06 2990 11 11 1.000 0.004 GO:0044267 BP 1 cellular protein metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.29e-06 1485 11 10 0.909 0.007 REAC:74160 rea 1 Gene Expression 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.11e-06 3185 11 11 1.000 0.003 GO:0019538 BP 1 protein metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 9.54e-06 1718 11 10 0.909 0.006 REAC:1430728 rea 1 Metabolism 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.89e-05 2627 11 10 0.909 0.004 GO:0016070 BP 1 RNA metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.53e-05 2707 11 10 0.909 0.004 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.17e-05 2770 11 10 0.909 0.004 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.46e-05 2869 11 10 0.909 0.003 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 5.21e-05 1984 11 9 0.818 0.005 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 Q15046,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 7.18e-05 3013 11 10 0.909 0.003 GO:0090304 BP 1 nucleic acid metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 8.29e-05 3058 11 10 0.909 0.003 GO:0010467 BP 1 gene expression 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.61e-04 3443 11 10 0.909 0.003 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.61e-04 775 11 6 0.545 0.008 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.05e-04 3499 11 10 0.909 0.003 GO:0044249 BP 1 cellular biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.54e-04 3554 11 10 0.909 0.003 GO:0046483 BP 1 heterocycle metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.61e-04 3561 11 10 0.909 0.003 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.69e-04 3569 11 10 0.909 0.003 GO:1901576 BP 1 organic substance biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.23e-04 3620 11 10 0.909 0.003 GO:0009058 BP 1 biosynthetic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.66e-04 1310 11 7 0.636 0.005 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 Q15046,P54136,P14868,O43324,Q12904,P56192,P41252 220 4.96e-04 3681 11 10 0.909 0.003 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 5.54e-04 4659 11 11 1.000 0.002 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 5.77e-04 4990 11 11 1.000 0.002 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 5.85e-04 4682 11 11 1.000 0.002 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 8.51e-04 21 11 2 0.182 0.095 REAC:379726 rea 1 Mitochondrial tRNA aminoacylation 1 Q15046,P47897 220 9.71e-04 3948 11 10 0.909 0.003 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 1.17e-03 5319 11 11 1.000 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 1.23e-03 1521 11 7 0.636 0.005 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.55e-03 1576 11 7 0.636 0.004 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.93e-03 29 11 2 0.182 0.069 GO:0000049 MF 1 tRNA binding 1 Q15046,Q12904 220 2.02e-03 4264 11 10 0.909 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 2.17e-03 5629 11 11 1.000 0.002 GO:0044444 CC 1 cytoplasmic part 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.24e-03 1670 11 7 0.636 0.004 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.36e-03 713 11 5 0.455 0.007 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q15046,P14868,Q12904,P56192,P47897 220 2.56e-03 5354 11 11 1.000 0.002 HPA:006010_02 hpa 1 cerebellum; Purkinje cells[Uncertain,Medium] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.89e-03 10 11 2 0.182 0.200 OMIM:312080 omi 1 Hypomyelinating Leukodystrophy 1 P54136,Q12904 220 3.45e-03 1787 11 7 0.636 0.004 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.48e-03 5505 11 11 1.000 0.002 HPA:007030_02 hpa 1 cerebral cortex; neuronal cells[Uncertain,Medium] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 3.78e-03 1813 11 7 0.636 0.004 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.84e-03 1818 11 7 0.636 0.004 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.94e-03 1825 11 7 0.636 0.004 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 4.20e-03 1274 11 6 0.545 0.005 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 5.23e-03 1909 11 7 0.636 0.004 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 5.50e-03 1924 11 7 0.636 0.004 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 5.54e-03 6128 11 11 1.000 0.002 GO:0044238 BP 1 primary metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 5.57e-03 389 11 3 0.273 0.008 MI:hsa-miR-606 mi 1 MI:hsa-miR-606 1 P14868,O43324,Q12904 220 5.57e-03 1 11 1 0.091 1.000 GO:0004824 MF 1 lysine-tRNA ligase activity 1 Q15046 220 5.57e-03 1 11 1 0.091 1.000 GO:0006430 BP 1 lysyl-tRNA aminoacylation 1 Q15046 220 5.57e-03 1 11 1 0.091 1.000 GO:0006425 BP 1 glutaminyl-tRNA aminoacylation 1 P47897 220 5.57e-03 1 11 1 0.091 1.000 GO:0005137 MF 1 interleukin-5 receptor binding 1 O00560 220 5.57e-03 1 11 1 0.091 1.000 GO:0006422 BP 1 aspartyl-tRNA aminoacylation 1 P14868 220 5.57e-03 1 11 1 0.091 1.000 GO:0005895 CC 1 interleukin-5 receptor complex 1 O00560 220 5.57e-03 1 11 1 0.091 1.000 GO:0004819 MF 1 glutamine-tRNA ligase activity 1 P47897 220 5.57e-03 1 11 1 0.091 1.000 GO:0017101 CC 1 aminoacyl-tRNA synthetase multienzyme complex 1 Q12904 220 5.57e-03 1 11 1 0.091 1.000 GO:0017102 CC 1 methionyl glutamyl tRNA synthetase complex 1 Q12904 220 5.64e-03 1932 11 7 0.636 0.004 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 5.90e-03 484 11 4 0.364 0.008 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q15046,P14868,Q12904,P47897 220 5.98e-03 1950 11 7 0.636 0.004 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 5.98e-03 399 11 3 0.273 0.008 MI:hsa-miR-508-3p mi 1 MI:hsa-miR-508-3p 1 P54136,O43324,P56192 220 5.99e-03 1360 11 6 0.545 0.004 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 6.45e-03 1974 11 7 0.636 0.004 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 6.79e-03 1990 11 7 0.636 0.004 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 6.92e-03 1996 11 7 0.636 0.004 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 6.96e-03 1998 11 7 0.636 0.004 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 7.08e-03 6266 11 11 1.000 0.002 GO:0044763 BP 1 single-organism cellular process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 7.50e-03 6299 11 11 1.000 0.002 GO:0044237 BP 1 cellular metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 7.90e-03 2039 11 7 0.636 0.003 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 8.14e-03 2049 11 7 0.636 0.003 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 8.19e-03 2051 11 7 0.636 0.003 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 8.70e-03 2071 11 7 0.636 0.003 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 8.88e-03 540 11 4 0.364 0.007 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q15046,P14868,Q12904,P56192 220 8.91e-03 2079 11 7 0.636 0.003 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q15046,P14868,O43324,Q12904,P56192,P47897,P41252 220 9.04e-03 463 11 3 0.273 0.006 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 Q15046,P14868,O00560 220 9.10e-03 2086 11 7 0.636 0.003 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 9.27e-03 2092 11 7 0.636 0.003 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 9.36e-03 469 11 3 0.273 0.006 MI:mmu-miR-685 mi 1 MI:mmu-miR-685 1 P54136,P14868,O00560 220 9.36e-03 469 11 3 0.273 0.006 MI:hsa-miR-891b mi 1 MI:hsa-miR-891b 1 Q15046,O43324,Q12904 220 9.54e-03 2102 11 7 0.636 0.003 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 9.77e-03 2110 11 7 0.636 0.003 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.00e-02 2119 11 7 0.636 0.003 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.03e-02 6484 11 11 1.000 0.002 GO:0071704 BP 1 organic substance metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 1.04e-02 564 11 4 0.364 0.007 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q15046,P14868,Q9P2J5,P56192 220 1.06e-02 2139 11 7 0.636 0.003 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.10e-02 2151 11 7 0.636 0.003 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.11e-02 2153 11 7 0.636 0.003 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.11e-02 2154 11 7 0.636 0.003 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.11e-02 2 11 1 0.091 0.500 GO:0004822 MF 1 isoleucine-tRNA ligase activity 1 P41252 220 1.11e-02 2 11 1 0.091 0.500 GO:0004815 MF 1 aspartate-tRNA ligase activity 1 P14868 220 1.11e-02 2 11 1 0.091 0.500 GO:0004823 MF 1 leucine-tRNA ligase activity 1 Q9P2J5 220 1.11e-02 2 11 1 0.091 0.500 GO:0004814 MF 1 arginine-tRNA ligase activity 1 P54136 220 1.11e-02 2 11 1 0.091 0.500 GO:0006429 BP 1 leucyl-tRNA aminoacylation 1 Q9P2J5 220 1.11e-02 2 11 1 0.091 0.500 GO:0004825 MF 1 methionine-tRNA ligase activity 1 P56192 220 1.11e-02 2 11 1 0.091 0.500 GO:0006428 BP 1 isoleucyl-tRNA aminoacylation 1 P41252 220 1.11e-02 2 11 1 0.091 0.500 GO:0004046 MF 1 aminoacylase activity 1 P14868 220 1.11e-02 2 11 1 0.091 0.500 GO:0006420 BP 1 arginyl-tRNA aminoacylation 1 P54136 220 1.13e-02 2159 11 7 0.636 0.003 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.16e-02 2168 11 7 0.636 0.003 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.21e-02 2183 11 7 0.636 0.003 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.22e-02 2188 11 7 0.636 0.003 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.25e-02 2197 11 7 0.636 0.003 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.27e-02 2202 11 7 0.636 0.003 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.30e-02 2209 11 7 0.636 0.003 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.32e-02 2215 11 7 0.636 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.34e-02 6642 11 11 1.000 0.002 GO:0008152 BP 1 metabolic process 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 1.36e-02 2227 11 7 0.636 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.36e-02 2227 11 7 0.636 0.003 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.38e-02 1589 11 6 0.545 0.004 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 1.43e-02 1600 11 6 0.545 0.004 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 1.52e-02 1619 11 6 0.545 0.004 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 1.53e-02 1621 11 6 0.545 0.004 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 1.53e-02 2270 11 7 0.636 0.003 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.54e-02 1622 11 6 0.545 0.004 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q15046,Q13155,Q9P2J5,Q12904,P56192,P47897 220 1.54e-02 1622 11 6 0.545 0.004 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 1.54e-02 2271 11 7 0.636 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.55e-02 2274 11 7 0.636 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.55e-02 2274 11 7 0.636 0.003 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.56e-02 565 11 3 0.273 0.005 MI:hsa-miR-548c-3p mi 1 MI:hsa-miR-548c-3p 1 Q13155,P14868,O00560 220 1.56e-02 2276 11 7 0.636 0.003 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.58e-02 2281 11 7 0.636 0.003 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.60e-02 2286 11 7 0.636 0.003 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.62e-02 2290 11 7 0.636 0.003 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.64e-02 2295 11 7 0.636 0.003 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.67e-02 3 11 1 0.091 0.333 GO:1903553 BP 1 positive regulation of extracellular exosome assembly 1 O00560 220 1.67e-02 1 11 1 0.091 1.000 OMIM:616280 omi 1 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2U; CMT2U;;CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 2U;;CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL DOMINANT, TYPE 2U 1 P56192 220 1.67e-02 1 11 1 0.091 1.000 OMIM:613641 omi 1 CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE B; CMTRIB;;CHARCOT-MARIE-TOOTH NEUROPATHY, RECESSIVE INTERMEDIATE B; RI-CMTB 1 Q15046 220 1.67e-02 1 11 1 0.091 1.000 OMIM:613916 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 89; DFNB89 1 Q15046 220 1.67e-02 1 11 1 0.091 1.000 OMIM:615486 omi 1 INTERSTITIAL LUNG AND LIVER DISEASE; ILLD;;PULMONARY ALVEOLAR PROTEINOSIS, REUNION ISLAND;;INFANTILE LIVER FAILURE SYNDROME 2, FORMERLY; ILFS2, FORMERLY 1 P56192 220 1.67e-02 1 11 1 0.091 1.000 OMIM:616140 omi 1 LEUKODYSTROPHY, HYPOMYELINATING, 9; HLD9 1 P54136 220 1.67e-02 1 11 1 0.091 1.000 OMIM:615281 omi 1 HYPOMYELINATION WITH BRAINSTEM AND SPINAL CORD INVOLVEMENT AND LEGSPASTICITY; HBSL;;ASPARTYL-tRNA SYNTHETASE DEFICIENCY 1 P14868 220 1.67e-02 1 11 1 0.091 1.000 OMIM:615760 omi 1 MICROCEPHALY, PROGRESSIVE, WITH SEIZURES AND CEREBRAL AND CEREBELLARATROPHY; MSCCA 1 P47897 220 1.67e-02 1 11 1 0.091 1.000 OMIM:260600 omi 1 LEUKODYSTROPHY, HYPOMYELINATING, 3; HLD3 1 Q12904 220 1.70e-02 2308 11 7 0.636 0.003 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.71e-02 2310 11 7 0.636 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.79e-02 2328 11 7 0.636 0.003 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.85e-02 2342 11 7 0.636 0.003 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 1.97e-02 2366 11 7 0.636 0.003 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.01e-02 1707 11 6 0.545 0.004 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 2.06e-02 628 11 3 0.273 0.005 MI:hsa-miR-519b-3p mi 1 MI:hsa-miR-519b-3p 1 Q13155,P14868,Q9P2J5 220 2.07e-02 2385 11 7 0.636 0.003 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.07e-02 7 11 1 0.091 0.143 REAC:447043 rea 1 Neurofascin interactions 1 O00560 220 2.07e-02 6474 11 11 1.000 0.002 HPA:027020_01 hpa 1 pancreas; islets of Langerhans[Uncertain,Low] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.10e-02 1152 11 5 0.455 0.004 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 Q15046,P14868,O43324,Q12904,P47897 220 2.12e-02 2395 11 7 0.636 0.003 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.13e-02 635 11 3 0.273 0.005 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 Q13155,P14868,Q9P2J5 220 2.14e-02 2397 11 7 0.636 0.003 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.15e-02 638 11 3 0.273 0.005 MI:hsa-miR-519c-3p mi 1 MI:hsa-miR-519c-3p 1 Q13155,P14868,Q9P2J5 220 2.23e-02 4 11 1 0.091 0.250 GO:2000774 BP 1 positive regulation of cellular senescence 1 O43324 220 2.25e-02 2417 11 7 0.636 0.003 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.29e-02 2425 11 7 0.636 0.003 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.31e-02 2429 11 7 0.636 0.003 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.33e-02 1756 11 6 0.545 0.003 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.35e-02 2435 11 7 0.636 0.003 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.37e-02 6993 11 11 1.000 0.002 GO:0005737 CC 1 cytoplasm 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 2.41e-02 153 11 4 0.364 0.026 HP:0011400 hp 1 Abnormal CNS myelination 1 P54136,P14868,Q12904,P47897 220 2.42e-02 1769 11 6 0.545 0.003 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 2.46e-02 2454 11 7 0.636 0.003 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.47e-02 2456 11 7 0.636 0.003 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.49e-02 2458 11 7 0.636 0.003 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.50e-02 1780 11 6 0.545 0.003 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 2.52e-02 1782 11 6 0.545 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.52e-02 2627 11 7 0.636 0.003 GO:0044421 CC 1 extracellular region part 1 P54136,P14868,O43324,O00560,Q12904,P56192,P41252 220 2.55e-02 2469 11 7 0.636 0.003 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.57e-02 2472 11 7 0.636 0.003 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.60e-02 2477 11 7 0.636 0.003 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.63e-02 1797 11 6 0.545 0.003 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.67e-02 1803 11 6 0.545 0.003 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 2.72e-02 2495 11 7 0.636 0.003 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.73e-02 2496 11 7 0.636 0.003 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.76e-02 3293 11 8 0.727 0.002 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 Q15046,Q13155,P14868,O43324,O00560,Q12904,P56192,P47897 220 2.78e-02 5 11 1 0.091 0.200 GO:0090343 BP 1 positive regulation of cell aging 1 O43324 220 2.78e-02 5 11 1 0.091 0.200 GO:0071971 BP 1 extracellular exosome assembly 1 O00560 220 2.78e-02 5 11 1 0.091 0.200 GO:0045545 MF 1 syndecan binding 1 O00560 220 2.78e-02 5 11 1 0.091 0.200 GO:1903551 BP 1 regulation of extracellular exosome assembly 1 O00560 220 2.79e-02 2505 11 7 0.636 0.003 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.81e-02 1820 11 6 0.545 0.003 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 2.89e-02 277 11 2 0.182 0.007 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 Q15046,Q13155 220 3.06e-02 1336 11 5 0.455 0.004 GO:0003723 MF 1 RNA binding 1 Q15046,P14868,O43324,Q12904,P47897 220 3.08e-02 2547 11 7 0.636 0.003 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.11e-02 1857 11 6 0.545 0.003 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.17e-02 1863 11 6 0.545 0.003 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.17e-02 291 11 2 0.182 0.007 MI:hsa-miR-16-2* mi 1 MI:hsa-miR-16-2* 1 P14868,Q12904 220 3.21e-02 293 11 2 0.182 0.007 MI:hsa-miR-374a* mi 1 MI:hsa-miR-374a* 1 O43324,Q12904 220 3.27e-02 2743 11 7 0.636 0.003 GO:0005576 CC 1 extracellular region 1 P54136,P14868,O43324,O00560,Q12904,P56192,P41252 220 3.34e-02 6 11 1 0.091 0.167 GO:0002091 BP 1 negative regulation of receptor internalization 1 O00560 220 3.34e-02 6 11 1 0.091 0.167 GO:0006930 BP 1 substrate-dependent cell migration, cell extension 1 O00560 220 3.34e-02 2 11 1 0.091 0.500 OMIM:608340 omi 1 Recessive Intermediate Charcot-Marie-Tooth Disease 1 Q15046 220 3.34e-02 1883 11 6 0.545 0.003 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 3.35e-02 3386 11 8 0.727 0.002 HPA:006030_02 hpa 1 cerebellum; cells in molecular layer[Uncertain,Medium] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192 220 3.47e-02 1291 11 5 0.455 0.004 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 Q13155,P14868,Q9P2J5,Q12904,P47897 220 3.54e-02 1904 11 6 0.545 0.003 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 3.82e-02 1932 11 6 0.545 0.003 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q15046,P14868,Q9P2J5,Q12904,P56192,P47897 220 3.87e-02 5480 11 10 0.909 0.002 HPA:035010_01 hpa 1 skin 1; Langerhans[Uncertain,Low] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 3.95e-02 328 11 2 0.182 0.006 MI:hsa-miR-126* mi 1 MI:hsa-miR-126* 1 Q15046,P56192 220 4.05e-02 1 11 1 0.091 1.000 HP:0006918 hp 1 Diffuse cerebral sclerosis 1 Q12904 220 4.05e-02 1 11 1 0.091 1.000 HP:0003269 hp 1 Sudanophilic leukodystrophy 1 Q12904 220 4.05e-02 1 11 1 0.091 1.000 HP:0002587 hp 1 Projectile vomiting 1 Q12904 220 4.08e-02 334 11 2 0.182 0.006 MI:hsa-miR-192* mi 1 MI:hsa-miR-192* 1 P54136,P14868 220 4.11e-02 5517 11 10 0.909 0.002 HPA:006030_01 hpa 1 cerebellum; cells in molecular layer[Uncertain,Low] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 220 4.39e-02 1986 11 6 0.545 0.003 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 4.43e-02 1989 11 6 0.545 0.003 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q15046,Q13155,P14868,Q9P2J5,Q12904,P56192 220 4.52e-02 1372 11 5 0.455 0.004 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q13155,P14868,Q9P2J5,Q12904,P56192 220 4.63e-02 358 11 2 0.182 0.006 MI:hsa-miR-15b* mi 1 MI:hsa-miR-15b* 1 Q15046,Q9P2J5 220 4.84e-02 2024 11 6 0.545 0.003 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q15046,Q13155,P14868,Q12904,P56192,P47897 220 4.85e-02 6994 11 11 1.000 0.002 HPA:020020_01 hpa 1 lateral ventricle; neuronal cells[Uncertain,Low] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 4.86e-02 2026 11 6 0.545 0.003 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q15046,Q13155,Q9P2J5,Q12904,P56192,P47897 220 5.00e-02 7013 11 11 1.000 0.002 HPA:018020_01 hpa 1 hippocampus; neuronal cells[Uncertain,Low] 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,O00560,Q12904,P56192,P47897,P41252 220 5.00e-02 48 11 2 0.182 0.042 TF:M00063_0 tf 1 Factor: IRF-2; motif: GAAAAGYGAAASY; match class: 0 1 Q15046,Q13155 220 5.00e-02 16 11 1 0.091 0.062 KEGG:00450 keg 1 Selenocompound metabolism 1 P56192 220 5.00e-02 17 11 1 0.091 0.059 REAC:3928664 rea 1 Ephrin signaling 1 O00560 220 5.00e-02 9 11 1 0.091 0.111 GO:0043517 BP 1 positive regulation of DNA damage response, signal transduction by p53 class mediator 1 O43324 220 5.00e-02 3 11 1 0.091 0.333 OMIM:615438 omi 1 Infantile Liver Failure Syndrome 1 Q9P2J5 220 5.00e-02 27 11 2 0.182 0.074 HP:0009027 hp 1 Foot dorsiflexor weakness 1 Q15046,P56192 220 5.00e-02 11 11 10 0.909 0.909 CORUM:3040 cor 1 Multisynthetase complex 1 Q15046,Q13155,P54136,P14868,O43324,Q9P2J5,Q12904,P56192,P47897,P41252 221 4.60e-03 1 7 1 0.143 1.000 OMIM:308990 omi 1 PROTEINURIA, LOW MOLECULAR WEIGHT, WITH HYPERCALCIURIA AND NEPHROCALCINOSIS 1 P51795 221 4.60e-03 1 7 1 0.143 1.000 OMIM:310468 omi 1 NEPHROLITHIASIS, X-LINKED RECESSIVE, WITH RENAL FAILURE; XRN;;NEPHROLITHIASIS, X-LINKED RECESSIVE, TYPE 1;;UROLITHIASIS, X-LINKED RECESSIVE, TYPE 1;;NEPHROLITHIASIS 1; NPHL1 1 P51795 221 4.60e-03 1 7 1 0.143 1.000 OMIM:300554 omi 1 HYPOPHOSPHATEMIC RICKETS, X-LINKED RECESSIVE 1 P51795 221 4.60e-03 1 7 1 0.143 1.000 OMIM:616287 omi 1 LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8 1 O43306 221 5.87e-03 190 7 3 0.429 0.016 GO:0005765 CC 1 lysosomal membrane 1 Q7Z2H8,Q8TCT8,P51795 221 5.87e-03 190 7 3 0.429 0.016 GO:0098852 CC 1 lytic vacuole membrane 1 Q7Z2H8,Q8TCT8,P51795 221 8.58e-03 216 7 3 0.429 0.014 GO:0005774 CC 1 vacuolar membrane 1 Q7Z2H8,Q8TCT8,P51795 221 9.19e-03 2 7 1 0.143 0.500 OMIM:300009 omi 1 Dent Disease 1 P51795 221 1.82e-02 279 7 3 0.429 0.011 GO:0044437 CC 1 vacuolar part 1 Q7Z2H8,Q8TCT8,P51795 221 1.83e-02 4 7 1 0.143 0.250 OMIM:193100 omi 1 Hypophosphatemic Rickets 1 P51795 221 2.29e-02 5 7 1 0.143 0.200 OMIM:264700 omi 1 Vitamin D-Dependent Rickets 1 P51795 221 2.43e-02 1 7 1 0.143 1.000 GO:1904117 BP 1 cellular response to vasopressin 1 O43306 221 2.43e-02 1 7 1 0.143 1.000 GO:1904116 BP 1 response to vasopressin 1 O43306 221 2.43e-02 1 7 1 0.143 1.000 GO:0035811 BP 1 negative regulation of urine volume 1 O43306 221 2.74e-02 6 7 1 0.143 0.167 OMIM:253310 omi 1 Lethal Congenital Contracture Syndrome 1 O43306 221 3.31e-02 342 7 3 0.429 0.009 GO:0000323 CC 1 lytic vacuole 1 Q7Z2H8,Q8TCT8,P51795 221 3.31e-02 342 7 3 0.429 0.009 GO:0005764 CC 1 lysosome 1 Q7Z2H8,Q8TCT8,P51795 221 3.56e-02 451 7 3 0.429 0.007 TF:M06766_0 tf 1 Factor: ZNF835; motif: RCWAAGATW; match class: 0 1 O00214,Q9BS91,P51795 221 3.75e-02 3 7 1 0.143 0.333 HP:0003126 hp 1 Low-molecular-weight proteinuria 1 P51795 221 3.75e-02 3 7 1 0.143 0.333 HP:0003152 hp 1 Increased serum 1,25-dihydroxyvitamin D3 1 P51795 221 4.22e-02 3 7 1 0.143 0.333 TF:M00957_1 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 1 1 Q7Z2H8 221 4.44e-02 324 7 2 0.286 0.006 MI:hsa-miR-379* mi 1 MI:hsa-miR-379* 1 Q8TCT8,P51795 221 4.48e-02 33 7 1 0.143 0.030 KEGG:04913 keg 1 Ovarian steroidogenesis 1 O43306 221 4.54e-02 328 7 2 0.286 0.006 MI:hsa-miR-519e* mi 1 MI:hsa-miR-519e* 1 Q9BS91,P51795 221 4.70e-02 334 7 2 0.286 0.006 MI:hsa-miR-380* mi 1 MI:hsa-miR-380* 1 O00214,P51795 221 4.86e-02 2 7 1 0.143 0.500 GO:0005280 MF 1 hydrogen:amino acid symporter activity 1 Q7Z2H8 221 5.00e-02 4 7 1 0.143 0.250 HP:0003020 hp 1 Enlargement of the wrists 1 P51795 221 5.00e-02 4 7 1 0.143 0.250 HP:0010502 hp 1 Fibular bowing 1 P51795 221 5.00e-02 4 7 1 0.143 0.250 HP:0003029 hp 1 Enlargement of the ankles 1 P51795 221 5.00e-02 4 7 1 0.143 0.250 HP:0000117 hp 1 Renal phosphate wasting 1 P51795 221 5.00e-02 4 7 1 0.143 0.250 HP:0003013 hp 1 Bulging epiphyses 1 P51795 221 5.00e-02 4 7 1 0.143 0.250 HP:0002752 hp 1 Sparse bone trabeculae 1 P51795 221 5.00e-02 11 7 1 0.143 0.091 OMIM:256100 omi 1 Nephronophthisis 1 P51795 221 5.00e-02 2111 7 5 0.714 0.002 TF:M01009_0 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 0 1 O00214,Q9NT99,Q9BS91,Q8TCT8,O43306 221 5.00e-02 345 7 2 0.286 0.006 MI:hsa-miR-411* mi 1 MI:hsa-miR-411* 1 Q8TCT8,P51795 221 5.00e-02 394 7 3 0.429 0.008 GO:0005773 CC 1 vacuole 1 Q7Z2H8,Q8TCT8,P51795 221 5.00e-02 1 7 1 0.143 1.000 REAC:428559 rea 1 Proton-coupled neutral amino acid transporters 1 Q7Z2H8 222 1.36e-06 6 2 2 1.000 0.333 REAC:111453 rea 1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1 O43521,P10415 222 8.18e-06 25 2 2 1.000 0.080 GO:1900739 BP 1 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521,P10415 222 8.18e-06 25 2 2 1.000 0.080 GO:1900740 BP 1 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521,P10415 222 9.58e-06 27 2 2 1.000 0.074 GO:0001844 BP 1 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 O43521,P10415 222 9.58e-06 27 2 2 1.000 0.074 GO:0051204 BP 1 protein insertion into mitochondrial membrane 1 O43521,P10415 222 1.27e-05 31 2 2 1.000 0.065 GO:2001244 BP 1 positive regulation of intrinsic apoptotic signaling pathway 1 O43521,P10415 222 1.35e-05 32 2 2 1.000 0.062 GO:0070059 BP 1 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1 O43521,P10415 222 1.35e-05 32 2 2 1.000 0.062 GO:1901030 BP 1 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 O43521,P10415 222 1.44e-05 33 2 2 1.000 0.061 GO:0051205 BP 1 protein insertion into membrane 1 O43521,P10415 222 1.62e-05 35 2 2 1.000 0.057 GO:0001836 BP 1 release of cytochrome c from mitochondria 1 O43521,P10415 222 1.92e-05 38 2 2 1.000 0.053 GO:1901028 BP 1 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 O43521,P10415 222 2.58e-05 44 2 2 1.000 0.045 GO:0097345 BP 1 mitochondrial outer membrane permeabilization 1 O43521,P10415 222 2.70e-05 45 2 2 1.000 0.044 GO:1902110 BP 1 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1 O43521,P10415 222 2.70e-05 45 2 2 1.000 0.044 GO:1902686 BP 1 mitochondrial outer membrane permeabilization involved in programmed cell death 1 O43521,P10415 222 2.82e-05 46 2 2 1.000 0.043 GO:1905710 BP 1 positive regulation of membrane permeability 1 O43521,P10415 222 2.82e-05 46 2 2 1.000 0.043 GO:0035794 BP 1 positive regulation of mitochondrial membrane permeability 1 O43521,P10415 222 2.95e-05 47 2 2 1.000 0.043 GO:1902108 BP 1 regulation of mitochondrial membrane permeability involved in apoptotic process 1 O43521,P10415 222 3.17e-05 27 2 2 1.000 0.074 REAC:114452 rea 1 Activation of BH3-only proteins 1 O43521,P10415 222 3.48e-05 51 2 2 1.000 0.039 GO:0046902 BP 1 regulation of mitochondrial membrane permeability 1 O43521,P10415 222 3.76e-05 53 2 2 1.000 0.038 GO:0090559 BP 1 regulation of membrane permeability 1 O43521,P10415 222 4.98e-05 30 2 2 1.000 0.067 KEGG:04215 keg 1 Apoptosis - multiple species 1 O43521,P10415 222 4.99e-05 61 2 2 1.000 0.033 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 O43521,P10415 222 5.50e-05 64 2 2 1.000 0.031 GO:1905477 BP 1 positive regulation of protein localization to membrane 1 O43521,P10415 222 6.69e-05 39 2 2 1.000 0.051 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 O43521,P10415 222 6.97e-05 72 2 2 1.000 0.028 GO:0007006 BP 1 mitochondrial membrane organization 1 O43521,P10415 222 8.19e-05 78 2 2 1.000 0.026 GO:0008637 BP 1 apoptotic mitochondrial changes 1 O43521,P10415 222 1.09e-04 90 2 2 1.000 0.022 GO:0005741 CC 1 mitochondrial outer membrane 1 O43521,P10415 222 1.17e-04 93 2 2 1.000 0.022 GO:1903749 BP 1 positive regulation of establishment of protein localization to mitochondrion 1 O43521,P10415 222 1.17e-04 93 2 2 1.000 0.022 GO:2001242 BP 1 regulation of intrinsic apoptotic signaling pathway 1 O43521,P10415 222 1.19e-04 94 2 2 1.000 0.021 GO:1905475 BP 1 regulation of protein localization to membrane 1 O43521,P10415 222 1.24e-04 96 2 2 1.000 0.021 GO:0031968 CC 1 organelle outer membrane 1 O43521,P10415 222 1.27e-04 97 2 2 1.000 0.021 GO:2001235 BP 1 positive regulation of apoptotic signaling pathway 1 O43521,P10415 222 1.27e-04 97 2 2 1.000 0.021 GO:0019867 CC 1 outer membrane 1 O43521,P10415 222 1.38e-04 101 2 2 1.000 0.020 GO:1903747 BP 1 regulation of establishment of protein localization to mitochondrion 1 O43521,P10415 222 2.39e-04 133 2 2 1.000 0.015 GO:0010822 BP 1 positive regulation of mitochondrion organization 1 O43521,P10415 222 2.97e-04 148 2 2 1.000 0.014 GO:0072655 BP 1 establishment of protein localization to mitochondrion 1 O43521,P10415 222 3.01e-04 73 2 2 1.000 0.027 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 O43521,P10415 222 3.05e-04 150 2 2 1.000 0.013 GO:0070585 BP 1 protein localization to mitochondrion 1 O43521,P10415 222 3.15e-04 1 2 1 0.500 1.000 GO:0032847 BP 1 regulation of cellular pH reduction 1 P10415 222 3.15e-04 1 2 1 0.500 1.000 GO:0032848 BP 1 negative regulation of cellular pH reduction 1 P10415 222 3.87e-04 169 2 2 1.000 0.012 GO:0097193 BP 1 intrinsic apoptotic signaling pathway 1 O43521,P10415 222 3.97e-04 171 2 2 1.000 0.012 GO:0010821 BP 1 regulation of mitochondrion organization 1 O43521,P10415 222 5.93e-04 209 2 2 1.000 0.010 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 O43521,P10415 222 6.16e-04 213 2 2 1.000 0.009 GO:2001233 BP 1 regulation of apoptotic signaling pathway 1 O43521,P10415 222 6.51e-04 219 2 2 1.000 0.009 GO:0006839 BP 1 mitochondrial transport 1 O43521,P10415 222 7.91e-04 118 2 2 1.000 0.017 KEGG:04210 keg 1 Apoptosis 1 O43521,P10415 222 8.22e-04 246 2 2 1.000 0.008 GO:1903829 BP 1 positive regulation of cellular protein localization 1 O43521,P10415 222 9.44e-04 3 2 1 0.500 0.333 GO:1904180 BP 1 negative regulation of membrane depolarization 1 P10415 222 9.44e-04 3 2 1 0.500 0.333 GO:0051902 BP 1 negative regulation of mitochondrial depolarization 1 P10415 222 9.44e-04 3 2 1 0.500 0.333 GO:2000271 BP 1 positive regulation of fibroblast apoptotic process 1 O43521 222 1.10e-03 139 2 2 1.000 0.014 KEGG:05206 keg 1 MicroRNAs in cancer 1 O43521,P10415 222 1.13e-03 159 2 2 1.000 0.013 REAC:109581 rea 1 Apoptosis 1 O43521,P10415 222 1.14e-03 290 2 2 1.000 0.007 GO:0090150 BP 1 establishment of protein localization to membrane 1 O43521,P10415 222 1.17e-03 293 2 2 1.000 0.007 GO:1904951 BP 1 positive regulation of establishment of protein localization 1 O43521,P10415 222 1.18e-03 162 2 2 1.000 0.012 REAC:5357801 rea 1 Programmed Cell Death 1 O43521,P10415 222 1.26e-03 4 2 1 0.500 0.250 GO:0051400 MF 1 BH domain binding 1 P10415 222 1.26e-03 4 2 1 0.500 0.250 GO:0051434 MF 1 BH3 domain binding 1 P10415 222 1.27e-03 306 2 2 1.000 0.007 GO:0043065 BP 1 positive regulation of apoptotic process 1 O43521,P10415 222 1.32e-03 311 2 2 1.000 0.006 GO:0043068 BP 1 positive regulation of programmed cell death 1 O43521,P10415 222 1.44e-03 325 2 2 1.000 0.006 GO:0010942 BP 1 positive regulation of cell death 1 O43521,P10415 222 1.48e-03 330 2 2 1.000 0.006 GO:0097190 BP 1 apoptotic signaling pathway 1 O43521,P10415 222 1.57e-03 5 2 1 0.500 0.200 GO:0043497 BP 1 regulation of protein heterodimerization activity 1 P10415 222 1.57e-03 5 2 1 0.500 0.200 GO:0051454 BP 1 intracellular pH elevation 1 P10415 222 1.57e-03 5 2 1 0.500 0.200 GO:1902237 BP 1 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1 O43521 222 1.57e-03 5 2 1 0.500 0.200 GO:0045852 BP 1 pH elevation 1 P10415 222 1.57e-03 5 2 1 0.500 0.200 GO:2000269 BP 1 regulation of fibroblast apoptotic process 1 O43521 222 1.57e-03 5 2 1 0.500 0.200 GO:0032464 BP 1 positive regulation of protein homooligomerization 1 O43521 222 1.57e-03 5 2 1 0.500 0.200 GO:0046930 CC 1 pore complex 1 P10415 222 1.76e-03 360 2 2 1.000 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 O43521,P10415 222 1.84e-03 368 2 2 1.000 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 O43521,P10415 222 1.85e-03 369 2 2 1.000 0.005 GO:0072657 BP 1 protein localization to membrane 1 O43521,P10415 222 1.89e-03 6 2 1 0.500 0.167 GO:0044346 BP 1 fibroblast apoptotic process 1 O43521 222 1.89e-03 6 2 1 0.500 0.167 GO:0070513 MF 1 death domain binding 1 P10415 222 1.94e-03 494 2 2 1.000 0.004 MI:hsa-miR-139-5p mi 1 MI:hsa-miR-139-5p 1 O43521,P10415 222 1.96e-03 3 2 1 0.500 0.333 REAC:844455 rea 1 The NLRP1 inflammasome 1 P10415 222 1.96e-03 3 2 1 0.500 0.333 REAC:111446 rea 1 Activation of BIM and translocation to mitochondria 1 O43521 222 2.05e-03 388 2 2 1.000 0.005 GO:0022414 BP 1 reproductive process 1 O43521,P10415 222 2.06e-03 389 2 2 1.000 0.005 GO:0000003 BP 1 reproduction 1 O43521,P10415 222 2.17e-03 399 2 2 1.000 0.005 GO:0031966 CC 1 mitochondrial membrane 1 O43521,P10415 222 2.20e-03 7 2 1 0.500 0.143 GO:0051900 BP 1 regulation of mitochondrial depolarization 1 P10415 222 2.20e-03 7 2 1 0.500 0.143 GO:1903896 BP 1 positive regulation of IRE1-mediated unfolded protein response 1 O43521 222 2.52e-03 8 2 1 0.500 0.125 GO:0010039 BP 1 response to iron ion 1 P10415 222 2.56e-03 434 2 2 1.000 0.005 GO:0005740 CC 1 mitochondrial envelope 1 O43521,P10415 222 2.83e-03 9 2 1 0.500 0.111 GO:0051882 BP 1 mitochondrial depolarization 1 P10415 222 2.97e-03 467 2 2 1.000 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 O43521,P10415 222 3.15e-03 10 2 1 0.500 0.100 GO:0032462 BP 1 regulation of protein homooligomerization 1 O43521 222 3.15e-03 10 2 1 0.500 0.100 GO:1903894 BP 1 regulation of IRE1-mediated unfolded protein response 1 O43521 222 3.15e-03 10 2 1 0.500 0.100 GO:1900103 BP 1 positive regulation of endoplasmic reticulum unfolded protein response 1 O43521 222 3.18e-03 483 2 2 1.000 0.004 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 O43521,P10415 222 3.18e-03 483 2 2 1.000 0.004 GO:0051050 BP 1 positive regulation of transport 1 O43521,P10415 222 3.20e-03 485 2 2 1.000 0.004 GO:0072594 BP 1 establishment of protein localization to organelle 1 O43521,P10415 222 3.54e-03 510 2 2 1.000 0.004 GO:0007005 BP 1 mitochondrion organization 1 O43521,P10415 222 3.54e-03 510 2 2 1.000 0.004 GO:0060341 BP 1 regulation of cellular localization 1 O43521,P10415 222 3.77e-03 257 2 2 1.000 0.008 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 O43521,P10415 222 3.77e-03 12 2 1 0.500 0.083 GO:0030890 BP 1 positive regulation of B cell proliferation 1 P10415 222 4.03e-03 544 2 2 1.000 0.004 GO:0032880 BP 1 regulation of protein localization 1 O43521,P10415 222 4.09e-03 13 2 1 0.500 0.077 GO:0035094 BP 1 response to nicotine 1 P10415 222 4.09e-03 13 2 1 0.500 0.077 GO:2000811 BP 1 negative regulation of anoikis 1 P10415 222 4.40e-03 14 2 1 0.500 0.071 GO:0043496 BP 1 regulation of protein homodimerization activity 1 P10415 222 4.40e-03 14 2 1 0.500 0.071 GO:0032461 BP 1 positive regulation of protein oligomerization 1 O43521 222 4.77e-03 592 2 2 1.000 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 O43521,P10415 222 5.03e-03 16 2 1 0.500 0.062 GO:1901099 BP 1 negative regulation of signal transduction in absence of ligand 1 P10415 222 5.03e-03 16 2 1 0.500 0.062 GO:1902235 BP 1 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1 O43521 222 5.03e-03 16 2 1 0.500 0.062 GO:1900101 BP 1 regulation of endoplasmic reticulum unfolded protein response 1 O43521 222 5.03e-03 16 2 1 0.500 0.062 GO:0032469 BP 1 endoplasmic reticulum calcium ion homeostasis 1 P10415 222 5.03e-03 16 2 1 0.500 0.062 GO:2001240 BP 1 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 P10415 222 5.35e-03 17 2 1 0.500 0.059 GO:0090200 BP 1 positive regulation of release of cytochrome c from mitochondria 1 O43521 222 5.40e-03 794 2 2 1.000 0.003 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 O43521,P10415 222 5.41e-03 630 2 2 1.000 0.003 GO:0044802 BP 1 single-organism membrane organization 1 O43521,P10415 222 5.66e-03 18 2 1 0.500 0.056 GO:0030888 BP 1 regulation of B cell proliferation 1 P10415 222 5.66e-03 18 2 1 0.500 0.056 GO:2000209 BP 1 regulation of anoikis 1 P10415 222 5.88e-03 657 2 2 1.000 0.003 GO:0033365 BP 1 protein localization to organelle 1 O43521,P10415 222 5.97e-03 19 2 1 0.500 0.053 GO:0003254 BP 1 regulation of membrane depolarization 1 P10415 222 6.02e-03 665 2 2 1.000 0.003 GO:0031967 CC 1 organelle envelope 1 O43521,P10415 222 6.08e-03 668 2 2 1.000 0.003 GO:0031975 CC 1 envelope 1 O43521,P10415 222 6.19e-03 674 2 2 1.000 0.003 GO:0044429 CC 1 mitochondrial part 1 O43521,P10415 222 6.29e-03 20 2 1 0.500 0.050 GO:0043276 BP 1 anoikis 1 P10415 222 6.29e-03 20 2 1 0.500 0.050 GO:2001239 BP 1 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 P10415 222 6.81e-03 707 2 2 1.000 0.003 GO:0033043 BP 1 regulation of organelle organization 1 O43521,P10415 222 6.81e-03 707 2 2 1.000 0.003 GO:0051130 BP 1 positive regulation of cellular component organization 1 O43521,P10415 222 6.92e-03 22 2 1 0.500 0.045 GO:0032459 BP 1 regulation of protein oligomerization 1 O43521 222 7.54e-03 24 2 1 0.500 0.042 GO:0050871 BP 1 positive regulation of B cell activation 1 P10415 222 7.54e-03 24 2 1 0.500 0.042 GO:0050853 BP 1 B cell receptor signaling pathway 1 P10415 222 7.58e-03 746 2 2 1.000 0.003 GO:0042981 BP 1 regulation of apoptotic process 1 O43521,P10415 222 7.64e-03 749 2 2 1.000 0.003 GO:0061024 BP 1 membrane organization 1 O43521,P10415 222 7.79e-03 756 2 2 1.000 0.003 GO:0043067 BP 1 regulation of programmed cell death 1 O43521,P10415 222 7.85e-03 759 2 2 1.000 0.003 GO:0098805 CC 1 whole membrane 1 O43521,P10415 222 7.93e-03 763 2 2 1.000 0.003 GO:0009967 BP 1 positive regulation of signal transduction 1 O43521,P10415 222 8.10e-03 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 O43521,P10415 222 8.49e-03 27 2 1 0.500 0.037 GO:0016248 MF 1 channel inhibitor activity 1 P10415 222 8.49e-03 27 2 1 0.500 0.037 GO:0090199 BP 1 regulation of release of cytochrome c from mitochondria 1 O43521 222 8.68e-03 798 2 2 1.000 0.003 GO:0010647 BP 1 positive regulation of cell communication 1 O43521,P10415 222 8.80e-03 28 2 1 0.500 0.036 GO:0043279 BP 1 response to alkaloid 1 P10415 222 8.81e-03 804 2 2 1.000 0.002 GO:0023056 BP 1 positive regulation of signaling 1 O43521,P10415 222 8.96e-03 811 2 2 1.000 0.002 GO:0010941 BP 1 regulation of cell death 1 O43521,P10415 222 9.11e-03 29 2 1 0.500 0.034 GO:0051881 BP 1 regulation of mitochondrial membrane potential 1 P10415 222 9.11e-03 29 2 1 0.500 0.034 GO:0042100 BP 1 B cell proliferation 1 P10415 222 9.43e-03 30 2 1 0.500 0.033 GO:0051452 BP 1 intracellular pH reduction 1 P10415 222 9.74e-03 31 2 1 0.500 0.032 GO:0045851 BP 1 pH reduction 1 P10415 222 9.75e-03 1257 2 2 1.000 0.002 TF:M00041_0 tf 1 Factor: ATF2:c-Jun; motif: TGACGTYA; match class: 0 1 O43521,P10415 222 9.78e-03 15 2 1 0.500 0.067 REAC:111447 rea 1 Activation of BAD and translocation to mitochondria 1 P10415 222 9.78e-03 15 2 1 0.500 0.067 REAC:622312 rea 1 Inflammasomes 1 P10415 222 1.01e-02 32 2 1 0.500 0.031 GO:0097192 BP 1 extrinsic apoptotic signaling pathway in absence of ligand 1 P10415 222 1.01e-02 32 2 1 0.500 0.031 GO:0038034 BP 1 signal transduction in absence of ligand 1 P10415 222 1.03e-02 66 2 1 0.500 0.015 TF:M06117_1 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 1 1 O43521 222 1.16e-02 37 2 1 0.500 0.027 GO:0007565 BP 1 female pregnancy 1 P10415 222 1.19e-02 936 2 2 1.000 0.002 GO:0006915 BP 1 apoptotic process 1 O43521,P10415 222 1.19e-02 936 2 2 1.000 0.002 GO:0051049 BP 1 regulation of transport 1 O43521,P10415 222 1.19e-02 38 2 1 0.500 0.026 GO:0050864 BP 1 regulation of B cell activation 1 P10415 222 1.19e-02 38 2 1 0.500 0.026 GO:0009636 BP 1 response to toxic substance 1 P10415 222 1.20e-02 1395 2 2 1.000 0.001 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 O43521,P10415 222 1.22e-02 945 2 2 1.000 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 O43521,P10415 222 1.25e-02 956 2 2 1.000 0.002 GO:0012501 BP 1 programmed cell death 1 O43521,P10415 222 1.26e-02 40 2 1 0.500 0.025 GO:0010507 BP 1 negative regulation of autophagy 1 P10415 222 1.29e-02 41 2 1 0.500 0.024 GO:0044706 BP 1 multi-multicellular organism process 1 P10415 222 1.38e-02 44 2 1 0.500 0.023 GO:0032946 BP 1 positive regulation of mononuclear cell proliferation 1 P10415 222 1.38e-02 44 2 1 0.500 0.023 GO:0050671 BP 1 positive regulation of lymphocyte proliferation 1 P10415 222 1.41e-02 45 2 1 0.500 0.022 GO:0043524 BP 1 negative regulation of neuron apoptotic process 1 P10415 222 1.41e-02 45 2 1 0.500 0.022 GO:0070665 BP 1 positive regulation of leukocyte proliferation 1 P10415 222 1.44e-02 1027 2 2 1.000 0.002 GO:1902531 BP 1 regulation of intracellular signal transduction 1 O43521,P10415 222 1.44e-02 1029 2 2 1.000 0.002 GO:0005739 CC 1 mitochondrion 1 O43521,P10415 222 1.44e-02 1029 2 2 1.000 0.002 GO:0008219 BP 1 cell death 1 O43521,P10415 222 1.47e-02 94 2 1 0.500 0.011 TF:M06284_0 tf 1 Factor: Cos52; motif: NNGTSSTAAAGC; match class: 0 1 P10415 222 1.60e-02 102 2 1 0.500 0.010 TF:M06385_0 tf 1 Factor: EZI; motif: NGGGCCTGGGGA; match class: 0 1 O43521 222 1.61e-02 1086 2 2 1.000 0.002 GO:0048584 BP 1 positive regulation of response to stimulus 1 O43521,P10415 222 1.65e-02 1100 2 2 1.000 0.002 GO:0045184 BP 1 establishment of protein localization 1 O43521,P10415 222 1.66e-02 53 2 1 0.500 0.019 GO:0007127 BP 1 meiosis I 1 O43521 222 1.68e-02 1111 2 2 1.000 0.002 GO:0034613 BP 1 cellular protein localization 1 O43521,P10415 222 1.71e-02 1121 2 2 1.000 0.002 GO:0070727 BP 1 cellular macromolecule localization 1 O43521,P10415 222 1.73e-02 55 2 1 0.500 0.018 GO:0051899 BP 1 membrane depolarization 1 P10415 222 1.73e-02 55 2 1 0.500 0.018 GO:0008625 BP 1 extrinsic apoptotic signaling pathway via death domain receptors 1 P10415 222 1.77e-02 113 2 1 0.500 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 O43521 222 1.78e-02 1440 2 2 1.000 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 O43521,P10415 222 1.79e-02 57 2 1 0.500 0.018 GO:0051453 BP 1 regulation of intracellular pH 1 P10415 222 1.82e-02 58 2 1 0.500 0.017 GO:0030641 BP 1 regulation of cellular pH 1 P10415 222 1.82e-02 58 2 1 0.500 0.017 GO:2001243 BP 1 negative regulation of intrinsic apoptotic signaling pathway 1 P10415 222 1.86e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 O43521,P10415 222 1.88e-02 60 2 1 0.500 0.017 GO:0036498 BP 1 IRE1-mediated unfolded protein response 1 O43521 222 1.88e-02 60 2 1 0.500 0.017 GO:2001237 BP 1 negative regulation of extrinsic apoptotic signaling pathway 1 P10415 222 1.91e-02 61 2 1 0.500 0.016 GO:0006885 BP 1 regulation of pH 1 P10415 222 1.91e-02 61 2 1 0.500 0.016 GO:1901215 BP 1 negative regulation of neuron death 1 P10415 222 1.95e-02 62 2 1 0.500 0.016 GO:0032944 BP 1 regulation of mononuclear cell proliferation 1 P10415 222 1.95e-02 62 2 1 0.500 0.016 GO:0050670 BP 1 regulation of lymphocyte proliferation 1 P10415 222 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 O43521,P10415 222 2.00e-02 1212 2 2 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 O43521,P10415 222 2.01e-02 64 2 1 0.500 0.016 GO:0070663 BP 1 regulation of leukocyte proliferation 1 P10415 222 2.10e-02 67 2 1 0.500 0.015 GO:0043523 BP 1 regulation of neuron apoptotic process 1 P10415 222 2.13e-02 1857 2 2 1.000 0.001 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 O43521,P10415 222 2.14e-02 37 2 1 0.500 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 P10415 222 2.22e-02 1897 2 2 1.000 0.001 TF:M00733_0 tf 1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 0 1 O43521,P10415 222 2.29e-02 73 2 1 0.500 0.014 GO:0030004 BP 1 cellular monovalent inorganic cation homeostasis 1 P10415 222 2.32e-02 74 2 1 0.500 0.014 GO:0051402 BP 1 neuron apoptotic process 1 P10415 222 2.34e-02 150 2 1 0.500 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 O43521 222 2.38e-02 76 2 1 0.500 0.013 GO:0016247 MF 1 channel regulator activity 1 P10415 222 2.38e-02 76 2 1 0.500 0.013 GO:0006959 BP 1 humoral immune response 1 P10415 222 2.41e-02 77 2 1 0.500 0.013 GO:0002020 MF 1 protease binding 1 P10415 222 2.44e-02 1989 2 2 1.000 0.001 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 O43521,P10415 222 2.45e-02 78 2 1 0.500 0.013 GO:0030307 BP 1 positive regulation of cell growth 1 P10415 222 2.45e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 O43521,P10415 222 2.47e-02 158 2 1 0.500 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 P10415 222 2.48e-02 159 2 1 0.500 0.006 TF:M06290_0 tf 1 Factor: Cos52; motif: NGGTCCDCCWGW; match class: 0 1 P10415 222 2.48e-02 159 2 1 0.500 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 O43521 222 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 O43521 222 2.51e-02 80 2 1 0.500 0.013 GO:0032943 BP 1 mononuclear cell proliferation 1 P10415 222 2.51e-02 80 2 1 0.500 0.013 GO:0046651 BP 1 lymphocyte proliferation 1 P10415 222 2.54e-02 81 2 1 0.500 0.012 GO:0051924 BP 1 regulation of calcium ion transport 1 P10415 222 2.59e-02 2048 2 2 1.000 0.001 TF:M02011_1 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 1 O43521,P10415 222 2.60e-02 83 2 1 0.500 0.012 GO:2001236 BP 1 regulation of extrinsic apoptotic signaling pathway 1 P10415 222 2.63e-02 84 2 1 0.500 0.012 GO:0055067 BP 1 monovalent inorganic cation homeostasis 1 P10415 222 2.63e-02 84 2 1 0.500 0.012 GO:0070661 BP 1 leukocyte proliferation 1 P10415 222 2.64e-02 2070 2 2 1.000 0.001 TF:M03553_0 tf 1 Factor: KLF3; motif: CCMCACCCNG; match class: 0 1 O43521,P10415 222 2.65e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 O43521,P10415 222 2.65e-02 1394 2 2 1.000 0.001 GO:0010033 BP 1 response to organic substance 1 O43521,P10415 222 2.70e-02 86 2 1 0.500 0.012 GO:0042113 BP 1 B cell activation 1 P10415 222 2.73e-02 1414 2 2 1.000 0.001 GO:0031090 CC 1 organelle membrane 1 O43521,P10415 222 2.76e-02 88 2 1 0.500 0.011 GO:2000021 BP 1 regulation of ion homeostasis 1 P10415 222 2.77e-02 48 2 1 0.500 0.021 KEGG:05014 keg 1 Amyotrophic lateral sclerosis (ALS) 1 P10415 222 2.79e-02 89 2 1 0.500 0.011 GO:0032845 BP 1 negative regulation of homeostatic process 1 P10415 222 2.82e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 O43521,P10415 222 2.82e-02 90 2 1 0.500 0.011 GO:0042493 BP 1 response to drug 1 P10415 222 2.86e-02 44 2 1 0.500 0.023 REAC:168643 rea 1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 1 P10415 222 2.91e-02 93 2 1 0.500 0.011 GO:0007126 BP 1 meiotic nuclear division 1 O43521 222 2.95e-02 2188 2 2 1.000 0.001 TF:M02279_0 tf 1 Factor: CREB1; motif: TGACGTCA; match class: 0 1 O43521,P10415 222 2.96e-02 190 2 1 0.500 0.005 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 O43521 222 2.99e-02 46 2 1 0.500 0.022 REAC:193648 rea 1 NRAGE signals death through JNK 1 O43521 222 3.01e-02 96 2 1 0.500 0.010 GO:0043393 BP 1 regulation of protein binding 1 P10415 222 3.01e-02 96 2 1 0.500 0.010 GO:0010038 BP 1 response to metal ion 1 P10415 222 3.01e-02 96 2 1 0.500 0.010 GO:0030968 BP 1 endoplasmic reticulum unfolded protein response 1 O43521 222 3.04e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 O43521,P10415 222 3.07e-02 98 2 1 0.500 0.010 GO:1903046 BP 1 meiotic cell cycle process 1 O43521 222 3.07e-02 98 2 1 0.500 0.010 GO:0051321 BP 1 meiotic cell cycle 1 O43521 222 3.10e-02 99 2 1 0.500 0.010 GO:0034620 BP 1 cellular response to unfolded protein 1 O43521 222 3.13e-02 100 2 1 0.500 0.010 GO:0051607 BP 1 defense response to virus 1 P10415 222 3.16e-02 101 2 1 0.500 0.010 GO:0045927 BP 1 positive regulation of growth 1 P10415 222 3.16e-02 101 2 1 0.500 0.010 GO:1901214 BP 1 regulation of neuron death 1 P10415 222 3.20e-02 1533 2 2 1.000 0.001 GO:0035556 BP 1 intracellular signal transduction 1 O43521,P10415 222 3.27e-02 210 2 1 0.500 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 O43521 222 3.29e-02 105 2 1 0.500 0.010 GO:0022898 BP 1 regulation of transmembrane transporter activity 1 P10415 222 3.34e-02 58 2 1 0.500 0.017 KEGG:05210 keg 1 Colorectal cancer 1 P10415 222 3.35e-02 2330 2 2 1.000 0.001 TF:M07141_0 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 0 1 O43521,P10415 222 3.37e-02 1573 2 2 1.000 0.001 GO:0009966 BP 1 regulation of signal transduction 1 O43521,P10415 222 3.49e-02 2379 2 2 1.000 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 O43521,P10415 222 3.54e-02 113 2 1 0.500 0.009 GO:0035967 BP 1 cellular response to topologically incorrect protein 1 O43521 222 3.55e-02 228 2 1 0.500 0.004 TF:M06114_0 tf 1 Factor: ZNF432; motif: NCRTCATMGCGM; match class: 0 1 O43521 222 3.57e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 O43521,P10415 222 3.57e-02 114 2 1 0.500 0.009 GO:0070997 BP 1 neuron death 1 P10415 222 3.60e-02 115 2 1 0.500 0.009 GO:0051251 BP 1 positive regulation of lymphocyte activation 1 P10415 222 3.63e-02 205 2 1 0.500 0.005 MI:hsa-miR-340* mi 1 MI:hsa-miR-340* 1 O43521 222 3.63e-02 116 2 1 0.500 0.009 GO:0032409 BP 1 regulation of transporter activity 1 P10415 222 3.72e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 O43521,P10415 222 3.76e-02 120 2 1 0.500 0.008 GO:2001234 BP 1 negative regulation of apoptotic signaling pathway 1 P10415 222 3.79e-02 121 2 1 0.500 0.008 GO:0006986 BP 1 response to unfolded protein 1 O43521 222 3.82e-02 122 2 1 0.500 0.008 GO:0097191 BP 1 extrinsic apoptotic signaling pathway 1 P10415 222 3.84e-02 59 2 1 0.500 0.017 REAC:204998 rea 1 Cell death signalling via NRAGE, NRIF and NADE 1 O43521 222 3.90e-02 1691 2 2 1.000 0.001 GO:0010646 BP 1 regulation of cell communication 1 O43521,P10415 222 3.91e-02 125 2 1 0.500 0.008 GO:0051260 BP 1 protein homooligomerization 1 O43521 222 3.92e-02 68 2 1 0.500 0.015 KEGG:04064 keg 1 NF-kappa B signaling pathway 1 P10415 222 3.94e-02 253 2 1 0.500 0.004 TF:M04017_0 tf 1 Factor: IRF5; motif: NACCGAAACYA; match class: 0 1 O43521 222 3.97e-02 127 2 1 0.500 0.008 GO:0002696 BP 1 positive regulation of leukocyte activation 1 P10415 222 4.00e-02 257 2 1 0.500 0.004 TF:M04203_1 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 1 1 O43521 222 4.02e-02 2165 2 2 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 O43521,P10415 222 4.07e-02 1728 2 2 1.000 0.001 GO:0023051 BP 1 regulation of signaling 1 O43521,P10415 222 4.09e-02 71 2 1 0.500 0.014 KEGG:01524 keg 1 Platinum drug resistance 1 P10415 222 4.12e-02 265 2 1 0.500 0.004 TF:M01735_1 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 1 1 P10415 222 4.13e-02 132 2 1 0.500 0.008 GO:0050867 BP 1 positive regulation of cell activation 1 P10415 222 4.19e-02 2605 2 2 1.000 0.001 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 O43521,P10415 222 4.29e-02 137 2 1 0.500 0.007 GO:0035966 BP 1 response to topologically incorrect protein 1 O43521 222 4.32e-02 278 2 1 0.500 0.004 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 O43521 222 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 O43521 222 4.43e-02 77 2 1 0.500 0.013 KEGG:05215 keg 1 Prostate cancer 1 P10415 222 4.47e-02 143 2 1 0.500 0.007 GO:0031334 BP 1 positive regulation of protein complex assembly 1 O43521 222 4.47e-02 143 2 1 0.500 0.007 GO:0034762 BP 1 regulation of transmembrane transport 1 P10415 222 4.47e-02 143 2 1 0.500 0.007 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 P10415 222 4.53e-02 145 2 1 0.500 0.007 GO:0010959 BP 1 regulation of metal ion transport 1 P10415 222 4.54e-02 292 2 1 0.500 0.003 TF:M04106_0 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 0 1 O43521 222 4.60e-02 1836 2 2 1.000 0.001 GO:0051641 BP 1 cellular localization 1 O43521,P10415 222 4.60e-02 147 2 1 0.500 0.007 GO:0031965 CC 1 nuclear membrane 1 P10415 222 4.71e-02 82 2 1 0.500 0.012 KEGG:04630 keg 1 Jak-STAT signaling pathway 1 P10415 222 4.78e-02 153 2 1 0.500 0.007 GO:0051249 BP 1 regulation of lymphocyte activation 1 P10415 222 4.78e-02 153 2 1 0.500 0.007 GO:0009615 BP 1 response to virus 1 P10415 222 4.80e-02 309 2 1 0.500 0.003 TF:M00919_1 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 1 1 O43521 222 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 O43521 222 4.83e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 O43521,P10415 222 4.83e-02 84 2 1 0.500 0.012 KEGG:05222 keg 1 Small cell lung cancer 1 P10415 222 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 O43521 222 4.91e-02 157 2 1 0.500 0.006 GO:0051098 BP 1 regulation of binding 1 P10415 222 4.91e-02 157 2 1 0.500 0.006 GO:0006816 BP 1 calcium ion transport 1 P10415 222 4.94e-02 86 2 1 0.500 0.012 KEGG:04933 keg 1 AGE-RAGE signaling pathway in diabetic complications 1 P10415 222 4.94e-02 86 2 1 0.500 0.012 KEGG:04066 keg 1 HIF-1 signaling pathway 1 P10415 222 5.00e-02 87 2 1 0.500 0.011 KEGG:01522 keg 1 Endocrine resistance 1 P10415 222 5.00e-02 2 2 1 0.500 0.500 HP:0012191 hp 1 B-cell lymphoma 1 P10415 222 5.00e-02 160 2 1 0.500 0.006 GO:0010035 BP 1 response to inorganic substance 1 P10415 222 5.00e-02 2 2 1 0.500 0.500 CORUM:5526 cor 1 CALM1-FKBP38-BCL2 complex 1 P10415 222 5.00e-02 2 2 1 0.500 0.500 CORUM:1062 cor 1 BAR-BCL2-CASP8 complex 1 P10415 223 1.47e-03 2256 4 4 1.000 0.002 TF:M04287_1 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.12e-03 2919 4 4 1.000 0.001 TF:M02054_0 tf 1 Factor: ELF2; motif: CCCGGAARYN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.37e-03 286 4 2 0.500 0.007 TF:M04414_1 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 1 1 Q8TBF4,Q9BRU9 223 4.68e-03 10 4 1 0.250 0.100 TF:M04230_1 tf 1 Factor: FOXB1; motif: WATGTAAATATTGACAYW; match class: 1 1 Q8TBF4 223 4.83e-03 301 4 2 0.500 0.007 TF:M07102_0 tf 1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 0 1 Q8TBF4,Q9BRU9 223 6.41e-03 180 4 2 0.500 0.011 REAC:72172 rea 1 mRNA Splicing 1 Q8IWX8,Q8TBF4 223 6.91e-03 361 4 2 0.500 0.006 TF:M04413_1 tf 1 Factor: NKX3-1; motif: NCCACTTAA; match class: 1 1 Q8TBF4,Q9BRU9 223 7.13e-03 3348 4 4 1.000 0.001 TF:M01252_0 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 8.13e-03 392 4 2 0.500 0.005 TF:M06504_0 tf 1 Factor: ZFP62; motif: TNGAAWACCKC; match class: 0 1 Q8IWX8,Q9BRU9 223 1.02e-02 228 4 2 0.500 0.009 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q8IWX8,Q8TBF4 223 1.23e-02 485 4 2 0.500 0.004 TF:M04213_0 tf 1 Factor: JDP2; motif: ATGACTCAT; match class: 0 1 Q8TBF4,Q9BRU9 223 1.23e-02 485 4 2 0.500 0.004 TF:M00495_0 tf 1 Factor: Bach1; motif: NNSATGAGTCATGNT; match class: 0 1 Q8TBF4,Q9BRU9 223 1.24e-02 1681 4 3 0.750 0.002 TF:M01652_0 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 0 1 Q8TBF4,P57071,Q9BRU9 223 1.31e-02 1714 4 3 0.750 0.002 TF:M01752_0 tf 1 Factor: ERG; motif: ACCGGAART; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 1.31e-02 28 4 1 0.250 0.036 TF:M05677_0 tf 1 Factor: ZNF816A; motif: KGGGAAAAMGGM; match class: 0 1 Q8TBF4 223 1.34e-02 3917 4 4 1.000 0.001 TF:M04333_0 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 1.35e-02 3924 4 4 1.000 0.001 TF:M04318_0 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 1.54e-02 543 4 2 0.500 0.004 TF:M01651_1 tf 1 Factor: P53; motif: RGRCATGYCYRGRCATGYYY; match class: 1 1 Q8TBF4,P57071 223 1.55e-02 4062 4 4 1.000 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 1.74e-02 4184 4 4 1.000 0.001 TF:M00476_0 tf 1 Factor: FOXO4; motif: NNGTTGTTTACNTN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 1.82e-02 4229 4 4 1.000 0.001 TF:M01250_1 tf 1 Factor: E2F-1; motif: CGTTTCNN; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 1.82e-02 1922 4 3 0.750 0.002 TF:M02062_0 tf 1 Factor: Erg; motif: ACCGGAAGTN; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 1.87e-02 4260 4 4 1.000 0.001 TF:M00474_0 tf 1 Factor: FOXO1; motif: GNNTTGTTTACNTT; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 2.04e-02 4354 4 4 1.000 0.001 TF:M04334_1 tf 1 Factor: HMX2; motif: ANCAMTTAANN; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 2.05e-02 44 4 1 0.250 0.023 TF:M04230_0 tf 1 Factor: FOXB1; motif: WATGTAAATATTGACAYW; match class: 0 1 Q8TBF4 223 2.08e-02 2136 4 4 1.000 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 2.25e-02 2071 4 3 0.750 0.001 TF:M03982_0 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 2.29e-02 667 4 2 0.500 0.003 TF:M01651_0 tf 1 Factor: P53; motif: RGRCATGYCYRGRCATGYYY; match class: 0 1 Q8TBF4,P57071 223 2.71e-02 4673 4 4 1.000 0.001 TF:M04300_1 tf 1 Factor: DLX2; motif: NYAATTAN; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 2.98e-02 2283 4 3 0.750 0.001 TF:M04324_1 tf 1 Factor: GBX2; motif: NNYAATTANN; match class: 1 1 Q8IWX8,Q8TBF4,Q9BRU9 223 3.04e-02 2299 4 3 0.750 0.001 TF:M02061_0 tf 1 Factor: ERF; motif: ACCGGAARYN; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 3.17e-02 4859 4 4 1.000 0.001 TF:M04360_1 tf 1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 3.24e-02 4887 4 4 1.000 0.001 TF:M02074_0 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 3.31e-02 809 4 2 0.500 0.002 TF:M03990_0 tf 1 Factor: GABPA; motif: ACCGGAAGTN; match class: 0 1 Q8IWX8,Q8TBF4 223 3.31e-02 809 4 2 0.500 0.002 TF:M02058_0 tf 1 Factor: SAP1A; motif: NCCGGAARYN; match class: 0 1 Q8IWX8,Q8TBF4 223 3.33e-02 2375 4 3 0.750 0.001 TF:M02072_0 tf 1 Factor: Pet-1; motif: ACCGGAWRTN; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 3.38e-02 818 4 2 0.500 0.002 TF:M04238_1 tf 1 Factor: FOXD2; motif: NRNWAATATTTAYN; match class: 1 1 Q8TBF4,Q9BRU9 223 3.64e-02 850 4 2 0.500 0.002 TF:M04333_1 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 1 1 Q8TBF4,Q9BRU9 223 3.67e-02 854 4 2 0.500 0.002 TF:M07095_0 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 0 1 Q8IWX8,Q8TBF4 223 3.76e-02 5073 4 4 1.000 0.001 TF:M04335_1 tf 1 Factor: HMX3; motif: NNCAMTTAANN; match class: 1 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 3.80e-02 2487 4 3 0.750 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 3.80e-02 2487 4 3 0.750 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 3.80e-02 2487 4 3 0.750 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 3.81e-02 870 4 2 0.500 0.002 TF:M06686_0 tf 1 Factor: PRDM9; motif: TTTGTGGAGA; match class: 0 1 Q8TBF4,Q9BRU9 223 3.91e-02 5123 4 4 1.000 0.001 TF:M03925_0 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 3.95e-02 85 4 1 0.250 0.012 TF:M00236_0 tf 1 Factor: Arnt; motif: NDDNNCACGTGNNNNN; match class: 0 1 P57071 223 4.08e-02 88 4 1 0.250 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 Q8IWX8 223 4.09e-02 5180 4 4 1.000 0.001 TF:M03563_0 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.13e-02 5192 4 4 1.000 0.001 TF:M07044_0 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.16e-02 912 4 2 0.500 0.002 TF:M04288_1 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 1 1 Q8TBF4,Q9BRU9 223 4.22e-02 91 4 1 0.250 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 P57071 223 4.30e-02 7 4 1 0.250 0.143 GO:0051533 BP 1 positive regulation of NFAT protein import into nucleus 1 Q8IWX8 223 4.30e-02 7 4 1 0.250 0.143 GO:0070181 MF 1 small ribosomal subunit rRNA binding 1 Q9BRU9 223 4.36e-02 94 4 1 0.250 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 Q8IWX8 223 4.40e-02 939 4 2 0.500 0.002 TF:M03843_1 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 1 1 P57071,Q9BRU9 223 4.40e-02 95 4 1 0.250 0.011 TF:M04356_0 tf 1 Factor: HOXC12; motif: RGTCGTAAAAN; match class: 0 1 Q9BRU9 223 4.43e-02 2626 4 3 0.750 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 4.65e-02 2612 4 4 1.000 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.66e-02 5351 4 4 1.000 0.001 TF:M01868_0 tf 1 Factor: CEBPepsilon; motif: HAANMTTKCNWMAC; match class: 0 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.67e-02 5019 4 4 1.000 0.001 HPA:028010_02 hpa 1 parathyroid gland; glandular cells[Uncertain,Medium] 1 Q8IWX8,Q8TBF4,P57071,Q9BRU9 223 4.80e-02 2702 4 3 0.750 0.001 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 Q8IWX8,Q8TBF4,P57071 223 4.90e-02 500 4 2 0.500 0.004 MI:hsa-miR-524-5p mi 1 MI:hsa-miR-524-5p 1 Q8TBF4,Q9BRU9 223 4.91e-02 106 4 1 0.250 0.009 TF:M05958_0 tf 1 Factor: ZNF286; motif: NTTGGCGGATGM; match class: 0 1 Q8IWX8 223 4.95e-02 107 4 1 0.250 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 Q9BRU9 223 4.95e-02 107 4 1 0.250 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 Q8IWX8 223 5.00e-02 23 4 1 0.250 0.043 CORUM:430 cor 1 18S U11/U12 snRNP 1 Q8TBF4 223 5.00e-02 51 4 1 0.250 0.020 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q8TBF4 223 5.00e-02 505 4 2 0.500 0.004 MI:hsa-miR-548a-5p mi 1 MI:hsa-miR-548a-5p 1 Q8TBF4,Q9BRU9 223 5.00e-02 108 4 1 0.250 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q9BRU9 224 2.86e-07 1175 9 8 0.889 0.007 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.84e-07 1256 9 8 0.889 0.006 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.38e-06 505 9 6 0.667 0.012 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.65e-06 564 9 6 0.667 0.011 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.93e-06 1578 9 8 0.889 0.005 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.45e-06 616 9 6 0.667 0.010 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.38e-06 1830 9 8 0.889 0.004 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.46e-05 755 9 6 0.667 0.008 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.77e-05 33 9 3 0.333 0.091 GO:0000380 BP 1 alternative mRNA splicing, via spliceosome 1 P52756,Q9H0G5,Q96I25 224 1.85e-05 786 9 6 0.667 0.008 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q7Z4V5,P98175,Q9UPN6 224 2.11e-05 804 9 6 0.667 0.007 HPA:019010_03 hpa 1 kidney; cells in glomeruli[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q7Z4V5,P98175,Q9UPN6 224 2.57e-05 832 9 6 0.667 0.007 HPA:009030_03 hpa 1 colon; peripheral nerve/ganglion[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,P98175 224 3.27e-05 867 9 6 0.667 0.007 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.42e-05 874 9 6 0.667 0.007 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.54e-05 879 9 6 0.667 0.007 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.59e-05 2173 9 8 0.889 0.004 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.62e-05 221 9 4 0.444 0.018 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 5.15e-05 938 9 6 0.667 0.006 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.31e-05 943 9 6 0.667 0.006 HPA:035040_03 hpa 1 skin 1; melanocytes[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.21e-05 969 9 6 0.667 0.006 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.46e-05 549 9 5 0.556 0.009 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,Q9UPN6 224 6.52e-05 977 9 6 0.667 0.006 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.19e-05 1583 9 7 0.778 0.004 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 7.20e-05 994 9 6 0.667 0.006 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.58e-05 2392 9 8 0.889 0.003 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.32e-05 3559 9 9 1.000 0.003 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.59e-05 1025 9 6 0.667 0.006 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,P98175,Q9UPN6 224 8.73e-05 1028 9 6 0.667 0.006 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q7Z4V5,P98175,Q9UPN6 224 9.25e-05 2454 9 8 0.889 0.003 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 9.61e-05 596 9 5 0.556 0.008 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.06e-04 608 9 5 0.556 0.008 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.15e-04 1078 9 6 0.667 0.006 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.17e-04 298 9 4 0.444 0.013 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 1.20e-04 624 9 5 0.556 0.008 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.23e-04 1091 9 6 0.667 0.005 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.29e-04 1100 9 6 0.667 0.005 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.31e-04 307 9 4 0.444 0.013 HPA:004010_03 hpa 1 breast; adipocytes[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5 224 1.34e-04 1107 9 6 0.667 0.005 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.44e-04 1121 9 6 0.667 0.005 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.49e-04 317 9 4 0.444 0.013 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 1.49e-04 1129 9 6 0.667 0.005 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.54e-04 1135 9 6 0.667 0.005 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.55e-04 658 9 5 0.556 0.008 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 1.72e-04 329 9 4 0.444 0.012 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,Q9UPN6 224 1.72e-04 1804 9 7 0.778 0.004 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 1.84e-04 682 9 5 0.556 0.007 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.91e-04 1179 9 6 0.667 0.005 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.98e-04 341 9 4 0.444 0.012 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.17e-04 349 9 4 0.444 0.011 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 P52756,Q8WW12,Q7Z4V5,Q9UPN6 224 2.27e-04 713 9 5 0.556 0.007 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.36e-04 357 9 4 0.444 0.011 HPA:034010_13 hpa 1 skeletal muscle; myocytes[Supportive,High] 1 P52756,Q8WW12,Q7Z4V5,Q9UPN6 224 2.44e-04 1230 9 6 0.667 0.005 HPA:041010_12 hpa 1 spleen; cells in red pulp[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.56e-04 1241 9 6 0.667 0.005 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 2.60e-04 733 9 5 0.556 0.007 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.64e-04 1247 9 6 0.667 0.005 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.66e-04 2813 9 8 0.889 0.003 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.66e-04 368 9 4 0.444 0.011 HPA:022020_13 hpa 1 lung; pneumocytes[Supportive,High] 1 P52756,Q8WW12,Q7Z4V5,Q9UPN6 224 2.69e-04 369 9 4 0.444 0.011 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 P52756,Q8WW12,Q96I25,Q7Z4V5 224 2.72e-04 1254 9 6 0.667 0.005 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,P98175 224 2.95e-04 753 9 5 0.556 0.007 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.98e-04 1274 9 6 0.667 0.005 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.10e-04 761 9 5 0.556 0.007 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.14e-04 265 9 4 0.444 0.015 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 3.14e-04 265 9 4 0.444 0.015 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 3.14e-04 384 9 4 0.444 0.010 HPA:040010_03 hpa 1 soft tissue 2; adipocytes[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5 224 3.33e-04 269 9 4 0.444 0.015 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 3.36e-04 391 9 4 0.444 0.010 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 3.38e-04 775 9 5 0.556 0.006 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.44e-04 1307 9 6 0.667 0.005 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.46e-04 1308 9 6 0.667 0.005 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.47e-04 394 9 4 0.444 0.010 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,P98175 224 3.49e-04 1310 9 6 0.667 0.005 HPA:046020_03 hpa 1 tonsil; non-germinal center cells[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.51e-04 781 9 5 0.556 0.006 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.57e-04 2013 9 7 0.778 0.003 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.63e-04 148 9 3 0.333 0.020 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 P52756,Q96I25,Q7Z4V5 224 3.77e-04 2029 9 7 0.778 0.003 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.82e-04 404 9 4 0.444 0.010 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 3.89e-04 798 9 5 0.556 0.006 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.91e-04 1337 9 6 0.667 0.004 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.98e-04 802 9 5 0.556 0.006 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,P98175 224 4.00e-04 4237 9 9 1.000 0.002 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.01e-04 803 9 5 0.556 0.006 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,P98175,Q9UPN6 224 4.23e-04 2988 9 8 0.889 0.003 HPA:009020_03 hpa 1 colon; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.27e-04 416 9 4 0.444 0.010 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 4.31e-04 2995 9 8 0.889 0.003 HPA:019020_03 hpa 1 kidney; cells in tubules[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.31e-04 1360 9 6 0.667 0.004 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.58e-04 160 9 3 0.333 0.019 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 P52756,Q96I25,Q7Z4V5 224 4.85e-04 836 9 5 0.556 0.006 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 4.99e-04 1396 9 6 0.667 0.004 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.24e-04 1408 9 6 0.667 0.004 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 5.45e-04 2146 9 7 0.778 0.003 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.47e-04 1419 9 6 0.667 0.004 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.49e-04 858 9 5 0.556 0.006 HPA:009010_03 hpa 1 colon; endothelial cells[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5,Q9UPN6 224 5.71e-04 4407 9 9 1.000 0.002 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.78e-04 2165 9 7 0.778 0.003 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.89e-04 871 9 5 0.556 0.006 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.95e-04 1440 9 6 0.667 0.004 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 5.98e-04 454 9 4 0.444 0.009 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q9UPN6 224 5.99e-04 2177 9 7 0.778 0.003 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q8WUA2,Q96I25,Q7Z4V5,Q9UPN6 224 6.00e-04 3127 9 8 0.889 0.003 HPA:022020_02 hpa 1 lung; pneumocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.08e-04 877 9 5 0.556 0.006 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 6.68e-04 1470 9 6 0.667 0.004 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.76e-04 4491 9 9 1.000 0.002 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.95e-04 902 9 5 0.556 0.006 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 7.06e-04 326 9 4 0.444 0.012 GO:0008380 BP 1 RNA splicing 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 7.09e-04 906 9 5 0.556 0.006 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 7.26e-04 1492 9 6 0.667 0.004 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.26e-04 3206 9 8 0.889 0.002 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 7.45e-04 1499 9 6 0.667 0.004 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.58e-04 919 9 5 0.556 0.005 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 7.65e-04 484 9 4 0.444 0.008 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 7.66e-04 921 9 5 0.556 0.005 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 7.70e-04 1508 9 6 0.667 0.004 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 7.74e-04 3233 9 8 0.889 0.002 HPA:041010_02 hpa 1 spleen; cells in red pulp[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 7.85e-04 1513 9 6 0.667 0.004 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.95e-04 489 9 4 0.444 0.008 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 7.98e-04 4574 9 9 1.000 0.002 HPA:021010_01 hpa 1 liver; bile duct cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.08e-04 1521 9 6 0.667 0.004 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.26e-04 2286 9 7 0.778 0.003 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 8.33e-04 495 9 4 0.444 0.008 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 P52756,Q8IX12,Q96I25,Q7Z4V5 224 8.42e-04 3269 9 8 0.889 0.002 HPA:010010_03 hpa 1 duodenum; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.51e-04 342 9 4 0.444 0.012 GO:0006397 BP 1 mRNA processing 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 8.51e-04 1535 9 6 0.667 0.004 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.52e-04 942 9 5 0.556 0.005 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 8.65e-04 945 9 5 0.556 0.005 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,P98175,Q9UPN6 224 8.82e-04 200 9 3 0.333 0.015 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 P52756,Q96I25,Q7Z4V5 224 8.95e-04 201 9 3 0.333 0.015 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 9.27e-04 509 9 4 0.444 0.008 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 P52756,Q8IX12,P98175,Q9UPN6 224 9.28e-04 1559 9 6 0.667 0.004 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.54e-04 965 9 5 0.556 0.005 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 9.68e-04 2342 9 7 0.778 0.003 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 1.03e-03 1589 9 6 0.667 0.004 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.03e-03 1589 9 6 0.667 0.004 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.07e-03 1599 9 6 0.667 0.004 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q7Z4V5,P98175,Q9UPN6 224 1.09e-03 531 9 4 0.444 0.008 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5 224 1.10e-03 995 9 5 0.556 0.005 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.14e-03 537 9 4 0.444 0.007 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.14e-03 1002 9 5 0.556 0.005 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 1.15e-03 1619 9 6 0.667 0.004 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.15e-03 1621 9 6 0.667 0.004 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.16e-03 1622 9 6 0.667 0.004 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.16e-03 1623 9 6 0.667 0.004 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.17e-03 541 9 4 0.444 0.007 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 P52756,Q8WW12,Q96I25,Q7Z4V5 224 1.31e-03 1659 9 6 0.667 0.004 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.33e-03 1663 9 6 0.667 0.004 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 1.36e-03 1670 9 6 0.667 0.004 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.37e-03 564 9 4 0.444 0.007 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.49e-03 3524 9 8 0.889 0.002 HPA:038010_02 hpa 1 smooth muscle; smooth muscle cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.52e-03 1704 9 6 0.667 0.004 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.54e-03 1707 9 6 0.667 0.004 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.59e-03 2527 9 7 0.778 0.003 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 1.60e-03 1078 9 5 0.556 0.005 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.61e-03 1722 9 6 0.667 0.003 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 1.61e-03 589 9 4 0.444 0.007 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 P52756,Q96I25,Q7Z4V5,Q9UPN6 224 1.64e-03 4954 9 9 1.000 0.002 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.74e-03 26 9 2 0.222 0.077 GO:0000381 BP 1 regulation of alternative mRNA splicing, via spliceosome 1 P52756,Q9H0G5 224 1.80e-03 1756 9 6 0.667 0.003 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.84e-03 2585 9 7 0.778 0.003 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 1.85e-03 1765 9 6 0.667 0.003 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.94e-03 1780 9 6 0.667 0.003 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.95e-03 1782 9 6 0.667 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.98e-03 1787 9 6 0.667 0.003 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.99e-03 1788 9 6 0.667 0.003 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.02e-03 1133 9 5 0.556 0.004 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.04e-03 1797 9 6 0.667 0.003 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.08e-03 1803 9 6 0.667 0.003 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.12e-03 270 9 3 0.333 0.011 HPA:040040_03 hpa 1 soft tissue 2; peripheral nerve[Uncertain,High] 1 Q96I25,Q7Z4V5,P98175 224 2.13e-03 634 9 4 0.444 0.006 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.14e-03 1813 9 6 0.667 0.003 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.15e-03 2647 9 7 0.778 0.003 HPA:001010_03 hpa 1 adrenal gland; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 2.18e-03 1152 9 5 0.556 0.004 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.18e-03 1818 9 6 0.667 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.19e-03 1820 9 6 0.667 0.003 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.22e-03 1825 9 6 0.667 0.003 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.34e-03 650 9 4 0.444 0.006 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 P52756,Q8WW12,Q7Z4V5,Q9UPN6 224 2.37e-03 652 9 4 0.444 0.006 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q8IX12,Q7Z4V5,P98175,Q9UPN6 224 2.38e-03 653 9 4 0.444 0.006 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.45e-03 1857 9 6 0.667 0.003 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.49e-03 1863 9 6 0.667 0.003 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.62e-03 1880 9 6 0.667 0.003 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.64e-03 1883 9 6 0.667 0.003 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.68e-03 674 9 4 0.444 0.006 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 P52756,Q8WW12,Q7Z4V5,Q9UPN6 224 2.70e-03 1890 9 6 0.667 0.003 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q7Z4V5,P98175,Q9UPN6 224 2.81e-03 1904 9 6 0.667 0.003 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.85e-03 1221 9 5 0.556 0.004 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.85e-03 1909 9 6 0.667 0.003 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.97e-03 1924 9 6 0.667 0.003 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.02e-03 2791 9 7 0.778 0.003 HPA:007020_02 hpa 1 cerebral cortex; glial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.04e-03 1932 9 6 0.667 0.003 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.04e-03 1932 9 6 0.667 0.003 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.05e-03 1933 9 6 0.667 0.003 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.08e-03 1242 9 5 0.556 0.004 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 3.12e-03 1941 9 6 0.667 0.003 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 3.12e-03 2805 9 7 0.778 0.002 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.19e-03 2815 9 7 0.778 0.002 HPA:041020_02 hpa 1 spleen; cells in white pulp[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.20e-03 1950 9 6 0.667 0.003 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.21e-03 3899 9 8 0.889 0.002 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.23e-03 3902 9 8 0.889 0.002 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.26e-03 3907 9 8 0.889 0.002 HPA:012010_01 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.32e-03 1263 9 5 0.556 0.004 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5 224 3.42e-03 1974 9 6 0.667 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.51e-03 5392 9 9 1.000 0.002 HPA:036010_02 hpa 1 skin 2; epidermal cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.51e-03 1984 9 6 0.667 0.003 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.56e-03 1989 9 6 0.667 0.003 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.57e-03 1990 9 6 0.667 0.003 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.61e-03 730 9 4 0.444 0.005 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q9UPN6 224 3.63e-03 1996 9 6 0.667 0.003 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.65e-03 1998 9 6 0.667 0.003 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.65e-03 2875 9 7 0.778 0.002 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 3.92e-03 2024 9 6 0.667 0.003 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.94e-03 2026 9 6 0.667 0.003 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 3.99e-03 5469 9 9 1.000 0.002 HPA:007020_01 hpa 1 cerebral cortex; glial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.03e-03 4019 9 8 0.889 0.002 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.04e-03 338 9 3 0.333 0.009 HPA:041010_13 hpa 1 spleen; cells in red pulp[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 4.06e-03 5480 9 9 1.000 0.002 HPA:035010_01 hpa 1 skin 1; Langerhans[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.12e-03 2043 9 6 0.667 0.003 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.19e-03 2049 9 6 0.667 0.003 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.20e-03 1329 9 5 0.556 0.004 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.21e-03 2051 9 6 0.667 0.003 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.21e-03 2051 9 6 0.667 0.003 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.28e-03 5512 9 9 1.000 0.002 HPA:002020_01 hpa 1 appendix; lymphoid tissue[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.29e-03 345 9 3 0.333 0.009 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 P52756,Q96I25,Q7Z4V5 224 4.36e-03 522 9 4 0.444 0.008 GO:0016071 BP 1 mRNA metabolic process 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 4.44e-03 2071 9 6 0.667 0.003 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.45e-03 2072 9 6 0.667 0.003 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.50e-03 351 9 3 0.333 0.009 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 4.54e-03 2974 9 7 0.778 0.002 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q8WUA2,Q96I25,Q7Z4V5,P98175 224 4.54e-03 352 9 3 0.333 0.009 HPA:039010_03 hpa 1 soft tissue 1; adipocytes[Uncertain,High] 1 P52756,Q8IX12,Q96I25 224 4.59e-03 42 9 2 0.222 0.048 GO:0048024 BP 1 regulation of mRNA splicing, via spliceosome 1 P52756,Q9H0G5 224 4.62e-03 2086 9 6 0.667 0.003 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.69e-03 2092 9 6 0.667 0.003 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.81e-03 2102 9 6 0.667 0.003 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.85e-03 1372 9 5 0.556 0.004 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5 224 4.94e-03 794 9 4 0.444 0.005 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5 224 4.96e-03 363 9 3 0.333 0.008 HPA:026020_03 hpa 1 ovary; ovarian stroma cells[Uncertain,High] 1 Q8IX12,Q7Z4V5,Q9UPN6 224 5.02e-03 2119 9 6 0.667 0.003 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.07e-03 5617 9 9 1.000 0.002 HPA:022010_02 hpa 1 lung; macrophages[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.17e-03 2130 9 6 0.667 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.23e-03 5636 9 9 1.000 0.002 HPA:014010_02 hpa 1 esophagus; squamous epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.25e-03 1396 9 5 0.556 0.004 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 5.25e-03 4163 9 8 0.889 0.002 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.29e-03 2139 9 6 0.667 0.003 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.29e-03 2139 9 6 0.667 0.003 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.45e-03 2151 9 6 0.667 0.003 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.45e-03 3061 9 7 0.778 0.002 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 5.45e-03 1408 9 5 0.556 0.004 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.48e-03 2153 9 6 0.667 0.003 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.49e-03 2154 9 6 0.667 0.003 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.56e-03 2159 9 6 0.667 0.003 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.68e-03 2168 9 6 0.667 0.003 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.74e-03 5694 9 9 1.000 0.002 HPA:035020_01 hpa 1 skin 1; fibroblasts[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.80e-03 2176 9 6 0.667 0.003 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.86e-03 4225 9 8 0.889 0.002 HPA:046010_02 hpa 1 tonsil; germinal center cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 5.90e-03 2183 9 6 0.667 0.003 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 5.97e-03 2188 9 6 0.667 0.003 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.02e-03 2191 9 6 0.667 0.003 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.06e-03 3113 9 7 0.778 0.002 HPA:039030_02 hpa 1 soft tissue 1; fibroblasts[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.11e-03 2197 9 6 0.667 0.003 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.18e-03 2202 9 6 0.667 0.003 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.29e-03 1453 9 5 0.556 0.003 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 6.29e-03 2209 9 6 0.667 0.003 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.38e-03 2215 9 6 0.667 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.40e-03 1459 9 5 0.556 0.003 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.46e-03 1462 9 5 0.556 0.003 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,P98175,Q9UPN6 224 6.49e-03 399 9 3 0.333 0.008 HPA:002020_13 hpa 1 appendix; lymphoid tissue[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5 224 6.57e-03 2227 9 6 0.667 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.57e-03 2227 9 6 0.667 0.003 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.60e-03 4293 9 8 0.889 0.002 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.68e-03 403 9 3 0.333 0.007 HPA:007010_03 hpa 1 cerebral cortex; endothelial cells[Uncertain,High] 1 Q8IX12,Q96I25,Q9UPN6 224 6.78e-03 4308 9 8 0.889 0.002 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 6.83e-03 867 9 4 0.444 0.005 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 6.83e-03 1480 9 5 0.556 0.003 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 6.90e-03 114 9 2 0.222 0.018 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q96I25,Q7Z4V5 224 7.28e-03 2270 9 6 0.667 0.003 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.29e-03 2271 9 6 0.667 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.35e-03 2274 9 6 0.667 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.35e-03 2274 9 6 0.667 0.003 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.38e-03 2276 9 6 0.667 0.003 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.43e-03 2279 9 6 0.667 0.003 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.47e-03 2281 9 6 0.667 0.003 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.56e-03 2286 9 6 0.667 0.003 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.63e-03 3228 9 7 0.778 0.002 HPA:037010_03 hpa 1 small intestine; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q7Z4V5,P98175,Q9UPN6 224 7.63e-03 2290 9 6 0.667 0.003 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.66e-03 1118 9 5 0.556 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 P52756,Q8IX12,Q9H0G5,Q8WUA2,P98175 224 7.72e-03 2295 9 6 0.667 0.003 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.95e-03 2308 9 6 0.667 0.003 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 7.99e-03 2310 9 6 0.667 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.33e-03 2328 9 6 0.667 0.003 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.39e-03 4433 9 8 0.889 0.002 HPA:034010_02 hpa 1 skeletal muscle; myocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.59e-03 4447 9 8 0.889 0.002 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 8.60e-03 2342 9 6 0.667 0.003 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.63e-03 3292 9 7 0.778 0.002 HPA:016010_03 hpa 1 gallbladder; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.65e-03 3293 9 7 0.778 0.002 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 8.82e-03 930 9 4 0.444 0.004 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 9.00e-03 1574 9 5 0.556 0.003 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.05e-03 1576 9 5 0.556 0.003 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.06e-03 131 9 2 0.222 0.015 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 Q96I25,Q7Z4V5 224 9.08e-03 2366 9 6 0.667 0.003 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.15e-03 4485 9 8 0.889 0.002 HPA:011010_01 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 9.23e-03 1583 9 5 0.556 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5 224 9.24e-03 3328 9 7 0.778 0.002 HPA:004010_01 hpa 1 breast; adipocytes[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.47e-03 2385 9 6 0.667 0.003 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.68e-03 1600 9 5 0.556 0.003 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q9UPN6 224 9.69e-03 2395 9 6 0.667 0.003 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.73e-03 2397 9 6 0.667 0.003 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 9.74e-03 136 9 2 0.222 0.015 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 P52756,Q96I25 224 9.83e-03 958 9 4 0.444 0.004 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5 224 9.85e-03 6046 9 9 1.000 0.001 HPA:008020_01 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.00e-02 3 9 1 0.111 0.333 HP:0000199 hp 1 Tongue nodules 1 P98175 224 1.02e-02 2417 9 6 0.667 0.002 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.03e-02 1622 9 5 0.556 0.003 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.03e-02 3386 9 7 0.778 0.002 HPA:006030_02 hpa 1 cerebellum; cells in molecular layer[Uncertain,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.03e-02 2425 9 6 0.667 0.002 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.04e-02 973 9 4 0.444 0.004 HPA:023010_03 hpa 1 lymph node; germinal center cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,Q9UPN6 224 1.04e-02 2429 9 6 0.667 0.002 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.06e-02 2435 9 6 0.667 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.06e-02 4575 9 8 0.889 0.002 HPA:018010_01 hpa 1 hippocampus; glial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.06e-02 1633 9 5 0.556 0.003 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.10e-02 2454 9 6 0.667 0.002 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.11e-02 2456 9 6 0.667 0.002 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.11e-02 2458 9 6 0.667 0.002 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.13e-02 486 9 3 0.333 0.006 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 1.13e-02 147 9 2 0.222 0.014 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q96I25,Q9UPN6 224 1.14e-02 2469 9 6 0.667 0.002 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.15e-02 2472 9 6 0.667 0.002 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.16e-02 2477 9 6 0.667 0.002 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.20e-02 2495 9 6 0.667 0.002 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.21e-02 2496 9 6 0.667 0.002 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.21e-02 4659 9 8 0.889 0.002 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,Q9UPN6 224 1.23e-02 2505 9 6 0.667 0.002 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.27e-02 70 9 2 0.222 0.029 GO:0050684 BP 1 regulation of mRNA processing 1 P52756,Q9H0G5 224 1.31e-02 6241 9 9 1.000 0.001 HPA:029020_02 hpa 1 placenta; trophoblastic cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.32e-02 3523 9 7 0.778 0.002 HPA:039040_01 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Low] 1 Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.34e-02 2547 9 6 0.667 0.002 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 1.39e-02 1055 9 4 0.444 0.004 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 P52756,Q9H0G5,Q7Z4V5,Q9UPN6 224 1.47e-02 6323 9 9 1.000 0.001 HPA:045010_02 hpa 1 thyroid gland; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.49e-02 6329 9 9 1.000 0.001 HPA:013010_02 hpa 1 epididymis; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.51e-02 6339 9 9 1.000 0.001 HPA:035040_01 hpa 1 skin 1; melanocytes[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.51e-02 1769 9 5 0.556 0.003 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 1.52e-02 540 9 3 0.333 0.006 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 1.58e-02 78 9 2 0.222 0.026 GO:0043484 BP 1 regulation of RNA splicing 1 P52756,Q9H0G5 224 1.59e-02 6377 9 9 1.000 0.001 HPA:021010 hpa 1 liver; bile duct cells 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.65e-02 4858 9 8 0.889 0.002 HPA:040030_01 hpa 1 soft tissue 2; fibroblasts[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175 224 1.68e-02 4872 9 8 0.889 0.002 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.73e-02 752 9 4 0.444 0.005 GO:0006396 BP 1 RNA processing 1 P52756,Q8IX12,Q9H0G5,Q96I25 224 1.74e-02 567 9 3 0.333 0.005 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 1.75e-02 1336 9 5 0.556 0.004 GO:0003723 MF 1 RNA binding 1 P52756,Q8IX12,Q9H0G5,Q8WUA2,P98175 224 1.85e-02 580 9 3 0.333 0.005 HPA:046010_13 hpa 1 tonsil; germinal center cells[Supportive,High] 1 P52756,Q7Z4V5,Q9UPN6 224 1.92e-02 3743 9 7 0.778 0.002 HPA:006020_02 hpa 1 cerebellum; cells in granular layer[Uncertain,Medium] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.97e-02 6530 9 9 1.000 0.001 HPA:015010_02 hpa 1 fallopian tube; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 1.99e-02 1885 9 5 0.556 0.003 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5 224 2.09e-02 90 9 2 0.222 0.022 GO:1903311 BP 1 regulation of mRNA metabolic process 1 P52756,Q9H0G5 224 2.15e-02 205 9 2 0.222 0.010 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 Q7Z4V5,Q9UPN6 224 2.16e-02 5041 9 8 0.889 0.002 HPA:020010_01 hpa 1 lateral ventricle; glial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.18e-02 6603 9 9 1.000 0.001 HPA:004030_01 hpa 1 breast; myoepithelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.19e-02 6607 9 9 1.000 0.001 HPA:002010_02 hpa 1 appendix; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.25e-02 173 9 3 0.333 0.017 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P52756,Q8IX12,Q96I25 224 2.32e-02 7 9 1 0.111 0.143 HP:0000395 hp 1 Prominent antihelix 1 P98175 224 2.33e-02 631 9 3 0.333 0.005 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 P52756,Q9H0G5,Q9UPN6 224 2.33e-02 1220 9 4 0.444 0.003 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,Q9UPN6 224 2.40e-02 217 9 2 0.222 0.009 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 P52756,Q7Z4V5 224 2.46e-02 6694 9 9 1.000 0.001 HPA:039030 hpa 1 soft tissue 1; fibroblasts 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.49e-02 1985 9 5 0.556 0.003 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q96I25,Q9UPN6 224 2.49e-02 1986 9 5 0.556 0.003 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.53e-02 180 9 3 0.333 0.017 REAC:72172 rea 1 mRNA Splicing 1 P52756,Q8IX12,Q96I25 224 2.55e-02 6719 9 9 1.000 0.001 HPA:024010_02 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.59e-02 3931 9 7 0.778 0.002 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 P52756,Q8IX12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,Q9UPN6 224 2.62e-02 3939 9 7 0.778 0.002 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175 224 2.64e-02 6747 9 9 1.000 0.001 HPA:048010_01 hpa 1 vagina; squamous epithelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.65e-02 661 9 3 0.333 0.005 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 P52756,Q8IX12,Q9UPN6 224 2.68e-02 6758 9 9 1.000 0.001 HPA:009010_01 hpa 1 colon; endothelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 2.73e-02 386 9 3 0.333 0.008 MI:hsa-miR-624 mi 1 MI:hsa-miR-624 1 P52756,Q9H0G5,Q8WUA2 224 2.75e-02 233 9 2 0.222 0.009 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 P52756,Q9UPN6 224 2.79e-02 2039 9 5 0.556 0.002 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 2.88e-02 2055 9 5 0.556 0.002 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.90e-02 4006 9 7 0.778 0.002 HPA:029010_02 hpa 1 placenta; decidual cells[Uncertain,Medium] 1 P52756,Q8IX12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175 224 2.91e-02 2060 9 5 0.556 0.002 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 2.99e-02 1310 9 4 0.444 0.003 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,Q9UPN6 224 3.03e-02 2079 9 5 0.556 0.002 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 P52756,Q8WW12,Q9H0G5,Q7Z4V5,Q9UPN6 224 3.18e-02 6886 9 9 1.000 0.001 HPA:002020 hpa 1 appendix; lymphoid tissue 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.19e-02 6889 9 9 1.000 0.001 HPA:001010_02 hpa 1 adrenal gland; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.23e-02 2110 9 5 0.556 0.002 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P52756,Q8WW12,Q96I25,Q7Z4V5,Q9UPN6 224 3.36e-02 6928 9 9 1.000 0.001 HPA:005010_02 hpa 1 bronchus; respiratory epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.49e-02 5386 9 8 0.889 0.001 HPA:032010_02 hpa 1 salivary gland; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.49e-02 5386 9 8 0.889 0.001 HPA:012020_02 hpa 1 endometrium 2; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.51e-02 265 9 2 0.222 0.008 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 Q96I25,Q7Z4V5 224 3.51e-02 265 9 2 0.222 0.008 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 P52756,Q9UPN6 224 3.54e-02 6969 9 9 1.000 0.001 HPA:035030_01 hpa 1 skin 1; keratinocytes[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.66e-02 6994 9 9 1.000 0.001 HPA:020020_01 hpa 1 lateral ventricle; neuronal cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.69e-02 272 9 2 0.222 0.007 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q8WW12,Q96I25 224 3.75e-02 7013 9 9 1.000 0.001 HPA:018020_01 hpa 1 hippocampus; neuronal cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.77e-02 275 9 2 0.222 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 P52756,Q7Z4V5 224 3.78e-02 7020 9 9 1.000 0.001 HPA:007020 hpa 1 cerebral cortex; glial cells 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.79e-02 1403 9 4 0.444 0.003 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 P52756,Q9H0G5,Q96I25,Q7Z4V5 224 3.95e-02 5479 9 8 0.889 0.001 HPA:007010_01 hpa 1 cerebral cortex; endothelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 3.97e-02 5483 9 8 0.889 0.001 HPA:046030_02 hpa 1 tonsil; squamous epithelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.03e-02 7071 9 9 1.000 0.001 HPA:035010 hpa 1 skin 1; Langerhans 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.17e-02 5520 9 8 0.889 0.001 HPA:011020_02 hpa 1 endometrium 1; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.18e-02 128 9 2 0.222 0.016 GO:0003729 MF 1 mRNA binding 1 P52756,Q9H0G5 224 4.29e-02 7119 9 9 1.000 0.001 HPA:025010_01 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Low] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q8WUA2,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.38e-02 3208 9 6 0.667 0.002 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.42e-02 2274 9 5 0.556 0.002 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q8WW12,P98175,Q9UPN6 224 4.42e-02 4298 9 7 0.778 0.002 HPA:009010_02 hpa 1 colon; endothelial cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q8WUA2,Q96I25,Q7Z4V5,Q9UPN6 224 4.64e-02 1488 9 4 0.444 0.003 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 Q8IX12,Q8WW12,P98175,Q9UPN6 224 4.66e-02 3247 9 6 0.667 0.002 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P52756,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,Q9UPN6 224 4.79e-02 2318 9 5 0.556 0.002 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P52756,Q8IX12,Q9H0G5,Q7Z4V5,Q9UPN6 224 4.81e-02 5632 9 8 0.889 0.001 HPA:004020_02 hpa 1 breast; glandular cells[Uncertain,Medium] 1 P52756,Q8IX12,Q8WW12,Q9H0G5,Q96I25,Q7Z4V5,P98175,Q9UPN6 224 4.92e-02 15 9 1 0.111 0.067 HP:0000162 hp 1 Glossoptosis 1 P98175 224 4.92e-02 15 9 1 0.111 0.067 HP:0006191 hp 1 Deep palmar crease 1 P98175 224 4.94e-02 1516 9 4 0.444 0.003 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 P52756,Q8IX12,Q7Z4V5,P98175 224 4.97e-02 477 9 3 0.333 0.006 MI:hsa-miR-489 mi 1 MI:hsa-miR-489 1 P52756,Q9H0G5,Q8WUA2 224 5.00e-02 1 9 1 0.111 1.000 OMIM:311900 omi 1 TARP SYNDROME; TARPS;;TALIPES EQUINOVARUS, ATRIAL SEPTAL DEFECT, ROBIN SEQUENCE, AND PERSISTENCEOF LEFT SUPERIOR VENA CAVA;;PIERRE ROBIN SYNDROME WITH CONGENITAL HEART MALFORMATION AND CLUBFOOT 1 P98175 224 5.00e-02 228 9 3 0.333 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P52756,Q8IX12,Q96I25 224 5.00e-02 10 9 1 0.111 0.100 CORUM:5286 cor 1 TNF-alpha/NF-kappa B signaling complex 10 1 Q8IX12 224 5.00e-02 478 9 3 0.333 0.006 MI:mmu-miR-547 mi 1 MI:mmu-miR-547 1 Q8IX12,Q8WUA2,Q96I25 224 5.00e-02 2529 9 6 0.667 0.002 GO:0005654 CC 1 nucleoplasm 1 P52756,Q8IX12,Q9H0G5,Q8WUA2,P98175,Q9UPN6 224 5.00e-02 178 9 3 0.333 0.017 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 Q8WW12,Q9H0G5,Q9UPN6 224 5.00e-02 838 9 3 0.333 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P52756,Q8WW12,Q9UPN6 225 8.40e-08 153 8 5 0.625 0.033 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 225 1.19e-07 54 8 4 0.500 0.074 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.19e-07 54 8 4 0.500 0.074 GO:0048208 BP 1 COPII vesicle coating 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.34e-07 522 8 7 0.875 0.013 REAC:199991 rea 1 Membrane Trafficking 1 O75865,Q9Y2L5,Q9UL33,Q7Z392,Q9Y5R8,Q8WVT3,Q8IUR0 225 1.38e-07 56 8 4 0.500 0.071 GO:0006901 BP 1 vesicle coating 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.49e-07 57 8 4 0.500 0.070 GO:0090114 BP 1 COPII-coated vesicle budding 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.71e-07 59 8 4 0.500 0.068 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.91e-07 549 8 7 0.875 0.013 REAC:5653656 rea 1 Vesicle-mediated transport 1 O75865,Q9Y2L5,Q9UL33,Q7Z392,Q9Y5R8,Q8WVT3,Q8IUR0 225 2.88e-07 67 8 4 0.500 0.060 GO:0006903 BP 1 vesicle targeting 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 5.31e-07 60 8 4 0.500 0.067 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.24e-06 96 8 4 0.500 0.042 GO:0006900 BP 1 membrane budding 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.67e-06 278 8 5 0.625 0.018 GO:0048193 BP 1 Golgi vesicle transport 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 225 2.02e-06 289 8 5 0.625 0.017 GO:0051656 BP 1 establishment of organelle localization 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 3.97e-06 331 8 5 0.625 0.015 GO:0051640 BP 1 organelle localization 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 8.42e-06 119 8 4 0.500 0.034 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.02e-05 4 8 2 0.250 0.500 GO:0030008 CC 1 TRAPP complex 1 Q9Y2L5,Q9Y5R8 225 1.11e-05 166 8 4 0.500 0.024 GO:0051650 BP 1 establishment of vesicle localization 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.38e-05 175 8 4 0.500 0.023 GO:0051648 BP 1 vesicle localization 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.70e-05 142 8 4 0.500 0.028 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 8.99e-05 281 8 4 0.500 0.014 GO:0016050 BP 1 vesicle organization 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.54e-04 248 8 4 0.500 0.016 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 3.83e-04 842 8 5 0.625 0.006 GO:0070271 BP 1 protein complex biogenesis 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 3.83e-04 842 8 5 0.625 0.006 GO:0006461 BP 1 protein complex assembly 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 4.16e-04 1493 8 6 0.750 0.004 GO:0051649 BP 1 establishment of localization in cell 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 7.13e-04 958 8 5 0.625 0.005 GO:0016192 BP 1 vesicle-mediated transport 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 225 8.94e-04 1706 8 6 0.750 0.004 GO:0022607 BP 1 cellular component assembly 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 9.39e-04 1015 8 5 0.625 0.005 GO:0071822 BP 1 protein complex subunit organization 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 1.36e-03 1836 8 6 0.750 0.003 GO:0051641 BP 1 cellular localization 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 1.46e-03 1113 8 5 0.625 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 1.58e-03 44 8 2 0.250 0.045 GO:0099023 CC 1 tethering complex 1 Q9Y2L5,Q9Y5R8 225 1.82e-03 1932 8 6 0.750 0.003 GO:0044085 BP 1 cellular component biogenesis 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 2.40e-03 1237 8 5 0.625 0.004 GO:0046907 BP 1 intracellular transport 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 225 2.79e-03 1 8 1 0.125 1.000 GO:0090233 BP 1 negative regulation of spindle checkpoint 1 Q8WVT3 225 2.79e-03 1 8 1 0.125 1.000 GO:1990072 CC 1 TRAPPIII protein complex 1 Q9Y2L5 225 2.79e-03 1 8 1 0.125 1.000 GO:1902426 BP 1 deactivation of mitotic spindle assembly checkpoint 1 Q8WVT3 225 3.13e-03 1 8 1 0.125 1.000 OMIM:615356 omi 1 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2S; LGMD2S 1 Q7Z392 225 4.02e-03 749 8 4 0.500 0.005 GO:0061024 BP 1 membrane organization 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 4.42e-03 2262 8 6 0.750 0.003 GO:0006996 BP 1 organelle organization 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 5.58e-03 2 8 1 0.125 0.500 GO:1905342 BP 1 positive regulation of protein localization to kinetochore 1 Q8WVT3 225 5.58e-03 2 8 1 0.125 0.500 GO:1905340 BP 1 regulation of protein localization to kinetochore 1 Q8WVT3 225 5.58e-03 2 8 1 0.125 0.500 GO:0032258 BP 1 CVT pathway 1 Q9Y2L5 225 8.31e-03 1614 8 5 0.625 0.003 GO:0043933 BP 1 macromolecular complex subunit organization 1 O75865,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 8.37e-03 3 8 1 0.125 0.333 GO:0090234 BP 1 regulation of kinetochore assembly 1 Q8WVT3 225 8.56e-03 712 8 4 0.500 0.006 REAC:597592 rea 1 Post-translational protein modification 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 1.12e-02 4 8 1 0.125 0.250 GO:0030242 BP 1 pexophagy 1 Q9Y2L5 225 1.12e-02 4 8 1 0.125 0.250 GO:1901977 BP 1 negative regulation of cell cycle checkpoint 1 Q8WVT3 225 1.12e-02 4 8 1 0.125 0.250 GO:0090230 BP 1 regulation of centromere complex assembly 1 Q8WVT3 225 1.30e-02 2748 8 6 0.750 0.002 GO:0051234 BP 1 establishment of localization 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 1.67e-02 6 8 1 0.125 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q8WVT3 225 1.67e-02 6 8 1 0.125 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q8WVT3 225 1.67e-02 6 8 1 0.125 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q8WVT3 225 2.78e-02 10 8 1 0.125 0.100 GO:0034497 BP 1 protein localization to pre-autophagosomal structure 1 Q9Y2L5 225 2.94e-02 10 8 1 0.125 0.100 HP:0006785 hp 1 Limb-girdle muscular dystrophy 1 Q7Z392 225 3.06e-02 11 8 1 0.125 0.091 GO:0051382 BP 1 kinetochore assembly 1 Q8WVT3 225 3.06e-02 11 8 1 0.125 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q8WVT3 225 3.06e-02 11 8 1 0.125 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q8WVT3 225 3.34e-02 12 8 1 0.125 0.083 GO:0051383 BP 1 kinetochore organization 1 Q8WVT3 225 3.62e-02 13 8 1 0.125 0.077 GO:0034501 BP 1 protein localization to kinetochore 1 Q8WVT3 225 3.89e-02 14 8 1 0.125 0.071 GO:0090231 BP 1 regulation of spindle checkpoint 1 Q8WVT3 225 4.14e-02 3401 8 6 0.750 0.002 GO:0051179 BP 1 localization 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8WVT3,Q8IUR0 225 4.45e-02 16 8 1 0.125 0.062 GO:0071459 BP 1 protein localization to chromosome, centromeric region 1 Q8WVT3 225 4.74e-02 1175 8 3 0.375 0.003 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q9UL33,Q9Y5R8,Q8WVT3 225 5.00e-02 18 8 1 0.125 0.056 GO:0044804 BP 1 nucleophagy 1 Q9Y2L5 225 5.00e-02 290 8 3 0.375 0.010 MI:hsa-miR-23b* mi 1 MI:hsa-miR-23b* 1 O75865,Q9Y5R8,Q8WVT3 225 5.00e-02 1169 8 4 0.500 0.003 REAC:392499 rea 1 Metabolism of proteins 1 O75865,Q9UL33,Q9Y5R8,Q8IUR0 225 5.00e-02 680 8 5 0.625 0.007 TF:M04194_1 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 1 1 O75865,Q9Y2L5,Q9UL33,Q9Y5R8,Q8IUR0 226 1.38e-02 27 2 1 0.500 0.037 REAC:76071 rea 1 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1 P52747 226 1.43e-02 20 2 1 0.500 0.050 GO:0006359 BP 1 regulation of transcription from RNA polymerase III promoter 1 P52747 226 1.74e-02 34 2 1 0.500 0.029 REAC:76046 rea 1 RNA Polymerase III Transcription Initiation 1 P52747 226 1.90e-02 37 2 1 0.500 0.027 REAC:74158 rea 1 RNA Polymerase III Transcription 1 P52747 226 1.90e-02 37 2 1 0.500 0.027 REAC:749476 rea 1 RNA Polymerase III Abortive And Retractive Initiation 1 P52747 226 2.86e-02 40 2 1 0.500 0.025 GO:0006383 BP 1 transcription from RNA polymerase III promoter 1 P52747 226 3.33e-02 2 2 1 0.500 0.500 TF:M06648_0 tf 1 Factor: znf607; motif: GAYAGTGAATGGGTTKGC; match class: 0 1 Q9BY78 226 3.58e-02 70 2 1 0.500 0.014 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 P52747 226 5.00e-02 98 2 1 0.500 0.010 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 P52747 226 5.00e-02 70 2 1 0.500 0.014 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 P52747 226 5.00e-02 3 2 1 0.500 0.333 TF:M06499_0 tf 1 Factor: znf383; motif: NGGTGGATAGGA; match class: 0 1 P52747 226 5.00e-02 387 2 2 1.000 0.005 MI:hsa-miR-933 mi 1 MI:hsa-miR-933 1 P52747,Q9BY78 226 5.00e-02 70 2 1 0.500 0.014 GO:0009301 BP 1 snRNA transcription 1 P52747 227 1.30e-07 1333 10 9 0.900 0.007 GO:0044281 BP 1 small molecule metabolic process 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,Q8N335,A6NDG6 227 6.28e-07 170 10 5 0.500 0.029 GO:0005996 BP 1 monosaccharide metabolic process 1 Q9H4Y5,P09972,Q14376,P04075,A6NDG6 227 9.35e-07 674 10 7 0.700 0.010 GO:0019637 BP 1 organophosphate metabolic process 1 Q9NPH2,P09972,P52209,P05026,P04075,Q8N335,A6NDG6 227 2.36e-06 86 10 4 0.400 0.047 GO:0046496 BP 1 nicotinamide nucleotide metabolic process 1 P09972,P52209,P04075,Q8N335 227 2.36e-06 86 10 4 0.400 0.047 GO:0019362 BP 1 pyridine nucleotide metabolic process 1 P09972,P52209,P04075,Q8N335 227 3.37e-06 94 10 4 0.400 0.043 GO:0006733 BP 1 oxidoreduction coenzyme metabolic process 1 P09972,P52209,P04075,Q8N335 227 3.83e-06 97 10 4 0.400 0.041 GO:0072524 BP 1 pyridine-containing compound metabolic process 1 P09972,P52209,P04075,Q8N335 227 7.09e-06 277 10 5 0.500 0.018 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 Q9H4Y5,P09972,Q14376,P04075,A6NDG6 227 8.18e-06 3 10 2 0.200 0.667 GO:0004332 MF 1 fructose-bisphosphate aldolase activity 1 P09972,P04075 227 1.53e-05 137 10 4 0.400 0.029 GO:0019318 BP 1 hexose metabolic process 1 P09972,Q14376,P04075,A6NDG6 227 1.53e-05 324 10 5 0.500 0.015 GO:0005975 BP 1 carbohydrate metabolic process 1 Q9H4Y5,P09972,Q14376,P04075,A6NDG6 227 2.13e-05 42 10 3 0.300 0.071 GO:0019674 BP 1 NAD metabolic process 1 P09972,P04075,Q8N335 227 2.46e-05 44 10 3 0.300 0.068 GO:0019320 BP 1 hexose catabolic process 1 P09972,Q14376,P04075 227 3.71e-05 388 10 5 0.500 0.013 GO:0009117 BP 1 nucleotide metabolic process 1 P09972,P52209,P05026,P04075,Q8N335 227 3.85e-05 51 10 3 0.300 0.059 GO:0006094 BP 1 gluconeogenesis 1 P09972,P04075,A6NDG6 227 4.08e-05 6 10 2 0.200 0.333 GO:0016832 MF 1 aldehyde-lyase activity 1 P09972,P04075 227 4.09e-05 52 10 3 0.300 0.058 GO:0046365 BP 1 monosaccharide catabolic process 1 P09972,Q14376,P04075 227 4.17e-05 2560 10 9 0.900 0.004 GO:0044710 BP 1 single-organism metabolic process 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,Q8N335,A6NDG6 227 4.20e-05 398 10 5 0.500 0.013 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P09972,P52209,P05026,P04075,Q8N335 227 4.59e-05 54 10 3 0.300 0.056 GO:0019319 BP 1 hexose biosynthetic process 1 P09972,P04075,A6NDG6 227 5.69e-05 58 10 3 0.300 0.052 GO:0046364 BP 1 monosaccharide biosynthetic process 1 P09972,P04075,A6NDG6 227 5.71e-05 7 10 2 0.200 0.286 GO:0030388 BP 1 fructose 1,6-bisphosphate metabolic process 1 P09972,P04075 227 5.80e-05 1851 10 8 0.800 0.004 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 Q9NPH2,P09972,P52209,P05026,P04075,Q8N335,O96017,A6NDG6 227 7.63e-05 450 10 5 0.500 0.011 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P09972,P52209,P05026,P04075,Q8N335 227 7.77e-05 1923 10 8 0.800 0.004 GO:0006793 BP 1 phosphorus metabolic process 1 Q9NPH2,P09972,P52209,P05026,P04075,Q8N335,O96017,A6NDG6 227 8.94e-05 214 10 4 0.400 0.019 GO:0006732 BP 1 coenzyme metabolic process 1 P09972,P52209,P04075,Q8N335 227 1.06e-04 4019 10 10 1.000 0.002 GO:0003824 MF 1 catalytic activity 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,Q8N335,O96017,A6NDG6 227 1.13e-04 26 10 3 0.300 0.115 KEGG:00030 keg 1 Pentose phosphate pathway 1 P09972,P52209,P04075 227 1.24e-04 75 10 3 0.300 0.040 GO:0006941 BP 1 striated muscle contraction 1 P05026,P04075,Q8N335 227 1.49e-04 11 10 2 0.200 0.182 GO:0006000 BP 1 fructose metabolic process 1 P09972,P04075 227 2.13e-04 267 10 4 0.400 0.015 GO:0051186 BP 1 cofactor metabolic process 1 P09972,P52209,P04075,Q8N335 227 2.67e-04 97 10 3 0.300 0.031 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 P09972,Q14376,P04075 227 2.88e-04 107 10 4 0.400 0.037 KEGG:01200 keg 1 Carbon metabolism 1 P09972,P52209,P04075,A6NDG6 227 3.11e-04 102 10 3 0.300 0.029 GO:0016052 BP 1 carbohydrate catabolic process 1 P09972,Q14376,P04075 227 3.89e-04 110 10 3 0.300 0.027 GO:0006006 BP 1 glucose metabolic process 1 P09972,P04075,A6NDG6 227 4.26e-04 319 10 4 0.400 0.013 GO:0019693 BP 1 ribose phosphate metabolic process 1 P09972,P52209,P05026,P04075 227 4.44e-04 115 10 3 0.300 0.026 GO:0016051 BP 1 carbohydrate biosynthetic process 1 P09972,P04075,A6NDG6 227 5.14e-04 20 10 2 0.200 0.100 GO:0010765 BP 1 positive regulation of sodium ion transport 1 P05026,Q8N335 227 6.83e-04 23 10 2 0.200 0.087 GO:2000649 BP 1 regulation of sodium ion transmembrane transporter activity 1 P05026,Q8N335 227 7.97e-04 375 10 4 0.400 0.011 GO:0055114 BP 1 oxidation-reduction process 1 Q9H4Y5,P09972,P52209,P04075 227 8.77e-04 26 10 2 0.200 0.077 GO:0061620 BP 1 glycolytic process through glucose-6-phosphate 1 P09972,P04075 227 8.77e-04 26 10 2 0.200 0.077 GO:0061718 BP 1 glucose catabolic process to pyruvate 1 P09972,P04075 227 8.77e-04 26 10 2 0.200 0.077 GO:0061621 BP 1 canonical glycolysis 1 P09972,P04075 227 8.77e-04 26 10 2 0.200 0.077 GO:0006735 BP 1 NADH regeneration 1 P09972,P04075 227 8.77e-04 26 10 2 0.200 0.077 GO:0061615 BP 1 glycolytic process through fructose-6-phosphate 1 P09972,P04075 227 1.02e-03 28 10 2 0.200 0.071 GO:0006007 BP 1 glucose catabolic process 1 P09972,P04075 227 1.04e-03 2707 10 8 0.800 0.003 GO:0005829 CC 1 cytosol 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P04075,Q8N335,A6NDG6 227 1.17e-03 30 10 2 0.200 0.067 GO:0006734 BP 1 NADH metabolic process 1 P09972,P04075 227 1.27e-03 164 10 3 0.300 0.018 GO:0006936 BP 1 muscle contraction 1 P05026,P04075,Q8N335 227 1.33e-03 32 10 2 0.200 0.062 GO:1902305 BP 1 regulation of sodium ion transmembrane transport 1 P05026,Q8N335 227 1.51e-03 34 10 2 0.200 0.059 GO:0016830 MF 1 carbon-carbon lyase activity 1 P09972,P04075 227 1.60e-03 35 10 2 0.200 0.057 GO:0086001 BP 1 cardiac muscle cell action potential 1 P05026,Q8N335 227 1.60e-03 851 10 5 0.500 0.006 GO:0044711 BP 1 single-organism biosynthetic process 1 Q9H4Y5,P09972,P04075,Q8N335,A6NDG6 227 1.61e-03 178 10 3 0.300 0.017 GO:0046034 BP 1 ATP metabolic process 1 P09972,P05026,P04075 227 1.92e-03 189 10 3 0.300 0.016 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P09972,P05026,P04075 227 1.95e-03 190 10 3 0.300 0.016 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P09972,P05026,P04075 227 1.95e-03 190 10 3 0.300 0.016 GO:0003012 BP 1 muscle system process 1 P05026,P04075,Q8N335 227 2.05e-03 193 10 3 0.300 0.016 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P09972,P05026,P04075 227 2.30e-03 201 10 3 0.300 0.015 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P09972,P05026,P04075 227 2.30e-03 201 10 3 0.300 0.015 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P09972,P05026,P04075 227 2.37e-03 203 10 3 0.300 0.015 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P09972,P05026,P04075 227 2.45e-03 246 10 4 0.400 0.016 REAC:71387 rea 1 Metabolism of carbohydrates 1 P09972,Q14376,P52209,P04075 227 2.48e-03 206 10 3 0.300 0.015 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P09972,P05026,P04075 227 2.51e-03 2194 10 7 0.700 0.003 GO:0070062 CC 1 extracellular exosome 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 2.59e-03 2205 10 7 0.700 0.003 GO:1903561 CC 1 extracellular vesicle 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 2.59e-03 2205 10 7 0.700 0.003 GO:0043230 CC 1 extracellular organelle 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 2.62e-03 210 10 3 0.300 0.014 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P09972,P05026,P04075 227 2.77e-03 46 10 2 0.200 0.043 GO:0002028 BP 1 regulation of sodium ion transport 1 P05026,Q8N335 227 3.14e-03 49 10 2 0.200 0.041 GO:0006096 BP 1 glycolytic process 1 P09972,P04075 227 3.21e-03 1565 10 6 0.600 0.004 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q9H4Y5,P09972,P52209,P05026,P04075,Q8N335 227 3.27e-03 50 10 2 0.200 0.040 GO:0006757 BP 1 ATP generation from ADP 1 P09972,P04075 227 3.50e-03 1 10 1 0.100 1.000 GO:1903464 BP 1 negative regulation of mitotic cell cycle DNA replication 1 O96017 227 3.50e-03 1 10 1 0.100 1.000 GO:1903463 BP 1 regulation of mitotic cell cycle DNA replication 1 O96017 227 3.50e-03 1 10 1 0.100 1.000 GO:0004616 MF 1 phosphogluconate dehydrogenase (decarboxylating) activity 1 P52209 227 3.50e-03 1 10 1 0.100 1.000 GO:0004512 MF 1 inositol-3-phosphate synthase activity 1 Q9NPH2 227 3.50e-03 1 10 1 0.100 1.000 GO:0044861 BP 1 protein transport into plasma membrane raft 1 P05026 227 3.50e-03 1 10 1 0.100 1.000 GO:0016872 MF 1 intramolecular lyase activity 1 Q9NPH2 227 3.50e-03 1 10 1 0.100 1.000 GO:0003978 MF 1 UDP-glucose 4-epimerase activity 1 Q14376 227 3.50e-03 1 10 1 0.100 1.000 GO:0072428 BP 1 signal transduction involved in intra-S DNA damage checkpoint 1 O96017 227 3.50e-03 1 10 1 0.100 1.000 GO:0043136 MF 1 glycerol-3-phosphatase activity 1 A6NDG6 227 3.53e-03 52 10 2 0.200 0.038 GO:0046031 BP 1 ADP metabolic process 1 P09972,P04075 227 3.81e-03 54 10 2 0.200 0.037 GO:0009135 BP 1 purine nucleoside diphosphate metabolic process 1 P09972,P04075 227 3.81e-03 54 10 2 0.200 0.037 GO:0009179 BP 1 purine ribonucleoside diphosphate metabolic process 1 P09972,P04075 227 3.86e-03 240 10 3 0.300 0.013 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P09972,P05026,P04075 227 4.00e-03 243 10 3 0.300 0.012 GO:0042278 BP 1 purine nucleoside metabolic process 1 P09972,P05026,P04075 227 4.10e-03 56 10 2 0.200 0.036 GO:0006165 BP 1 nucleoside diphosphate phosphorylation 1 P09972,P04075 227 4.10e-03 56 10 2 0.200 0.036 GO:0009185 BP 1 ribonucleoside diphosphate metabolic process 1 P09972,P04075 227 4.15e-03 246 10 3 0.300 0.012 GO:0044282 BP 1 small molecule catabolic process 1 P09972,Q14376,P04075 227 4.24e-03 57 10 2 0.200 0.035 GO:0060048 BP 1 cardiac muscle contraction 1 P05026,Q8N335 227 4.24e-03 57 10 2 0.200 0.035 GO:0046939 BP 1 nucleotide phosphorylation 1 P09972,P04075 227 4.40e-03 251 10 3 0.300 0.012 GO:0009119 BP 1 ribonucleoside metabolic process 1 P09972,P05026,P04075 227 4.86e-03 61 10 2 0.200 0.033 GO:0019751 BP 1 polyol metabolic process 1 Q9NPH2,A6NDG6 227 5.02e-03 62 10 2 0.200 0.032 GO:0035725 BP 1 sodium ion transmembrane transport 1 P05026,Q8N335 227 5.02e-03 62 10 2 0.200 0.032 GO:0009132 BP 1 nucleoside diphosphate metabolic process 1 P09972,P04075 227 6.09e-03 281 10 3 0.300 0.011 GO:0009116 BP 1 nucleoside metabolic process 1 P09972,P05026,P04075 227 6.20e-03 69 10 2 0.200 0.029 GO:0001508 BP 1 action potential 1 P05026,Q8N335 227 6.33e-03 1 10 1 0.100 1.000 OMIM:611881 omi 1 GLYCOGEN STORAGE DISEASE XII; GSD12;;GSD XII;;ALDOLASE A DEFICIENCY;;ALDOA DEFICIENCY;;ALDOLASE DEFICIENCY, RED CELL;;RED CELL ALDOLASE DEFICIENCY 1 P04075 227 6.33e-03 1 10 1 0.100 1.000 OMIM:230350 omi 1 GALACTOSE EPIMERASE DEFICIENCY;;GALE DEFICIENCY;;GALACTOSEMIA III;;UDP-GALACTOSE-4-EPIMERASE DEFICIENCY 1 Q14376 227 6.33e-03 1 10 1 0.100 1.000 OMIM:609265 omi 1 LI-FRAUMENI SYNDROME 2; LFS2 1 O96017 227 6.33e-03 1 10 1 0.100 1.000 OMIM:611777 omi 1 BRUGADA SYNDROME 2; BRGDA2 1 Q8N335 227 6.56e-03 2173 10 6 0.600 0.003 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q9H4Y5,Q9NPH2,Q14376,P05026,O96017,A6NDG6 227 6.99e-03 2 10 1 0.100 0.500 GO:0090038 BP 1 negative regulation of protein kinase C signaling 1 Q8N335 227 6.99e-03 2 10 1 0.100 0.500 GO:0045174 MF 1 glutathione dehydrogenase (ascorbate) activity 1 Q9H4Y5 227 6.99e-03 2 10 1 0.100 0.500 GO:0008967 MF 1 phosphoglycolate phosphatase activity 1 A6NDG6 227 6.99e-03 2 10 1 0.100 0.500 GO:0004367 MF 1 glycerol-3-phosphate dehydrogenase [NAD+] activity 1 Q8N335 227 6.99e-03 2 10 1 0.100 0.500 GO:0032596 BP 1 protein transport into membrane raft 1 P05026 227 6.99e-03 2 10 1 0.100 0.500 GO:0009051 BP 1 pentose-phosphate shunt, oxidative branch 1 P52209 227 6.99e-03 2 10 1 0.100 0.500 GO:0060373 BP 1 regulation of ventricular cardiac muscle cell membrane depolarization 1 Q8N335 227 6.99e-03 2 10 1 0.100 0.500 GO:1903281 BP 1 positive regulation of calcium:sodium antiporter activity 1 P05026 227 7.29e-03 299 10 3 0.300 0.010 GO:1901657 BP 1 glycosyl compound metabolic process 1 P09972,P05026,P04075 227 7.51e-03 76 10 2 0.200 0.026 GO:0006090 BP 1 pyruvate metabolic process 1 P09972,P04075 227 7.57e-03 303 10 3 0.300 0.010 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P09972,P05026,P04075 227 7.64e-03 304 10 3 0.300 0.010 GO:0044283 BP 1 small molecule biosynthetic process 1 P09972,P04075,A6NDG6 227 7.86e-03 307 10 3 0.300 0.010 GO:0009259 BP 1 ribonucleotide metabolic process 1 P09972,P05026,P04075 227 7.88e-03 2627 10 7 0.700 0.003 GO:0044421 CC 1 extracellular region part 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 8.76e-03 32 10 2 0.200 0.062 REAC:70171 rea 1 Glycolysis 1 P09972,P04075 227 8.76e-03 32 10 2 0.200 0.062 REAC:70263 rea 1 Gluconeogenesis 1 P09972,P04075 227 9.17e-03 324 10 3 0.300 0.009 GO:0006163 BP 1 purine nucleotide metabolic process 1 P09972,P05026,P04075 227 1.03e-02 89 10 2 0.200 0.022 GO:0043270 BP 1 positive regulation of ion transport 1 P05026,Q8N335 227 1.03e-02 89 10 2 0.200 0.022 GO:0006814 BP 1 sodium ion transport 1 P05026,Q8N335 227 1.03e-02 2743 10 7 0.700 0.003 GO:0005576 CC 1 extracellular region 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 1.05e-02 3 10 1 0.100 0.333 GO:1903278 BP 1 positive regulation of sodium ion export from cell 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0001302 BP 1 replicative cell aging 1 O96017 227 1.05e-02 3 10 1 0.100 0.333 GO:1903276 BP 1 regulation of sodium ion export from cell 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0032594 BP 1 protein transport within lipid bilayer 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:1902576 BP 1 negative regulation of nuclear cell cycle DNA replication 1 O96017 227 1.05e-02 3 10 1 0.100 0.333 GO:0006114 BP 1 glycerol biosynthetic process 1 A6NDG6 227 1.05e-02 3 10 1 0.100 0.333 GO:1903279 BP 1 regulation of calcium:sodium antiporter activity 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:1903275 BP 1 positive regulation of sodium ion export 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0044860 BP 1 protein localization to plasma membrane raft 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:1990573 BP 1 potassium ion import across plasma membrane 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0098519 MF 1 nucleotide phosphatase activity, acting on free nucleotides 1 A6NDG6 227 1.05e-02 3 10 1 0.100 0.333 GO:1903273 BP 1 regulation of sodium ion export 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:1903288 BP 1 positive regulation of potassium ion import 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0019401 BP 1 alditol biosynthetic process 1 A6NDG6 227 1.05e-02 3 10 1 0.100 0.333 GO:1903286 BP 1 regulation of potassium ion import 1 P05026 227 1.05e-02 3 10 1 0.100 0.333 GO:0016672 MF 1 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor 1 Q9H4Y5 227 1.05e-02 90 10 2 0.200 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P52209,Q8N335 227 1.14e-02 350 10 3 0.300 0.009 GO:0072521 BP 1 purine-containing compound metabolic process 1 P09972,P05026,P04075 227 1.16e-02 2795 10 7 0.700 0.003 GO:0031982 CC 1 vesicle 1 Q9H4Y5,P09972,Q14376,P52209,P05026,P04075,Q8N335 227 1.24e-02 98 10 2 0.200 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P52209,Q8N335 227 1.27e-02 6484 10 10 1.000 0.002 GO:0071704 BP 1 organic substance metabolic process 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,Q8N335,O96017,A6NDG6 227 1.35e-02 32 10 2 0.200 0.062 KEGG:00051 keg 1 Fructose and mannose metabolism 1 P09972,P04075 227 1.37e-02 798 10 4 0.400 0.005 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P09972,P52209,P05026,P04075 227 1.39e-02 104 10 2 0.200 0.019 GO:0050821 BP 1 protein stabilization 1 P05026,O96017 227 1.39e-02 104 10 2 0.200 0.019 GO:0032412 BP 1 regulation of ion transmembrane transporter activity 1 P05026,Q8N335 227 1.40e-02 1108 10 4 0.400 0.004 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 Q14376,P05026,O96017,A6NDG6 227 1.42e-02 105 10 2 0.200 0.019 GO:0022898 BP 1 regulation of transmembrane transporter activity 1 P05026,Q8N335 227 1.44e-02 3 10 1 0.100 0.333 HP:0012024 hp 1 Hypergalactosemia 1 Q14376 227 1.44e-02 3 10 1 0.100 0.333 HP:0009919 hp 1 Retinoblastoma 1 O96017 227 1.44e-02 3 10 1 0.100 0.333 HP:0012777 hp 1 Retinal neoplasm 1 O96017 227 1.61e-02 6642 10 10 1.000 0.002 GO:0008152 BP 1 metabolic process 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,Q8N335,O96017,A6NDG6 227 1.64e-02 113 10 2 0.200 0.018 GO:1904062 BP 1 regulation of cation transmembrane transport 1 P05026,Q8N335 227 1.73e-02 116 10 2 0.200 0.017 GO:0032409 BP 1 regulation of transporter activity 1 P05026,Q8N335 227 1.73e-02 116 10 2 0.200 0.017 GO:0008016 BP 1 regulation of heart contraction 1 P05026,Q8N335 227 1.75e-02 5 10 1 0.100 0.200 GO:0015038 MF 1 glutathione disulfide oxidoreductase activity 1 Q9H4Y5 227 1.75e-02 5 10 1 0.100 0.200 GO:0070061 MF 1 fructose binding 1 P04075 227 1.75e-02 5 10 1 0.100 0.200 GO:1902969 BP 1 mitotic DNA replication 1 O96017 227 1.75e-02 5 10 1 0.100 0.200 GO:1903044 BP 1 protein localization to membrane raft 1 P05026 227 1.87e-02 121 10 2 0.200 0.017 GO:0016829 MF 1 lyase activity 1 P09972,P04075 227 1.89e-02 3 10 1 0.100 0.333 OMIM:259500 omi 1 OSTEOGENIC SARCOMA;;OSTEOSARCOMA; OSRC 1 O96017 227 1.92e-02 4 10 1 0.100 0.250 HP:0030078 hp 1 Lung adenocarcinoma 1 O96017 227 1.92e-02 4 10 1 0.100 0.250 HP:0030358 hp 1 Non-small cell lung carcinoma 1 O96017 227 2.03e-02 126 10 2 0.200 0.016 GO:0016853 MF 1 isomerase activity 1 Q9NPH2,Q14376 227 2.09e-02 128 10 2 0.200 0.016 GO:0060047 BP 1 heart contraction 1 P05026,Q8N335 227 2.09e-02 6 10 1 0.100 0.167 GO:0086013 BP 1 membrane repolarization during cardiac muscle cell action potential 1 P05026 227 2.09e-02 6 10 1 0.100 0.167 GO:0015037 MF 1 peptide disulfide oxidoreductase activity 1 Q9H4Y5 227 2.09e-02 6 10 1 0.100 0.167 GO:0090036 BP 1 regulation of protein kinase C signaling 1 Q8N335 227 2.09e-02 6 10 1 0.100 0.167 GO:0031402 MF 1 sodium ion binding 1 P05026 227 2.12e-02 1941 10 5 0.500 0.003 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q9H4Y5,Q9NPH2,Q14376,P05026,O96017 227 2.16e-02 130 10 2 0.200 0.015 GO:0003015 BP 1 heart process 1 P05026,Q8N335 227 2.35e-02 136 10 2 0.200 0.015 GO:0034765 BP 1 regulation of ion transmembrane transport 1 P05026,Q8N335 227 2.40e-02 5 10 1 0.100 0.200 HP:0001930 hp 1 Nonspherocytic hemolytic anemia 1 P04075 227 2.40e-02 5 10 1 0.100 0.200 HP:0012023 hp 1 Galactosuria 1 Q14376 227 2.44e-02 7 10 1 0.100 0.143 GO:0005890 CC 1 sodium:potassium-exchanging ATPase complex 1 P05026 227 2.44e-02 7 10 1 0.100 0.143 GO:0019388 BP 1 galactose catabolic process 1 Q14376 227 2.44e-02 7 10 1 0.100 0.143 GO:2000010 BP 1 positive regulation of protein localization to cell surface 1 Q8N335 227 2.44e-02 7 10 1 0.100 0.143 GO:0030955 MF 1 potassium ion binding 1 P05026 227 2.52e-02 4 10 1 0.100 0.250 OMIM:601144 omi 1 Brugada Syndrome 1 Q8N335 227 2.52e-02 141 10 2 0.200 0.014 GO:1903522 BP 1 regulation of blood circulation 1 P05026,Q8N335 227 2.59e-02 143 10 2 0.200 0.014 GO:0034762 BP 1 regulation of transmembrane transport 1 P05026,Q8N335 227 2.67e-02 45 10 2 0.200 0.044 KEGG:00480 keg 1 Glutathione metabolism 1 Q9H4Y5,P52209 227 2.67e-02 145 10 2 0.200 0.014 GO:0010959 BP 1 regulation of metal ion transport 1 P05026,Q8N335 227 2.67e-02 1718 10 7 0.700 0.004 REAC:1430728 rea 1 Metabolism 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P04075,Q8N335 227 2.78e-02 480 10 3 0.300 0.006 GO:0016491 MF 1 oxidoreductase activity 1 Q9H4Y5,P52209,Q8N335 227 2.79e-02 8 10 1 0.100 0.125 GO:0045721 BP 1 negative regulation of gluconeogenesis 1 A6NDG6 227 2.79e-02 8 10 1 0.100 0.125 GO:0006071 BP 1 glycerol metabolic process 1 A6NDG6 227 2.79e-02 8 10 1 0.100 0.125 GO:0006975 BP 1 DNA damage induced protein phosphorylation 1 O96017 227 2.79e-02 8 10 1 0.100 0.125 GO:0071243 BP 1 cellular response to arsenic-containing substance 1 Q9H4Y5 227 2.79e-02 8 10 1 0.100 0.125 GO:0019852 BP 1 L-ascorbic acid metabolic process 1 Q9H4Y5 227 2.79e-02 8 10 1 0.100 0.125 GO:0090399 BP 1 replicative senescence 1 O96017 227 2.79e-02 8 10 1 0.100 0.125 GO:0006012 BP 1 galactose metabolic process 1 Q14376 227 2.87e-02 6 10 1 0.100 0.167 HP:0004915 hp 1 Impairment of galactose metabolism 1 Q14376 227 2.87e-02 6 10 1 0.100 0.167 HP:0006744 hp 1 Adrenocortical carcinoma 1 O96017 227 3.14e-02 9 10 1 0.100 0.111 GO:0005391 MF 1 sodium:potassium-exchanging ATPase activity 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0031420 MF 1 alkali metal ion binding 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0090533 CC 1 cation-transporting ATPase complex 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0016857 MF 1 racemase and epimerase activity, acting on carbohydrates and derivatives 1 Q14376 227 3.14e-02 9 10 1 0.100 0.111 GO:0033262 BP 1 regulation of nuclear cell cycle DNA replication 1 O96017 227 3.14e-02 9 10 1 0.100 0.111 GO:0008556 MF 1 potassium-transporting ATPase activity 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0055119 BP 1 relaxation of cardiac muscle 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0086011 BP 1 membrane repolarization during action potential 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:0019400 BP 1 alditol metabolic process 1 A6NDG6 227 3.14e-02 9 10 1 0.100 0.111 GO:0036376 BP 1 sodium ion export from cell 1 P05026 227 3.14e-02 9 10 1 0.100 0.111 GO:2000651 BP 1 positive regulation of sodium ion transmembrane transporter activity 1 P05026 227 3.15e-02 158 10 2 0.200 0.013 GO:0006066 BP 1 alcohol metabolic process 1 Q9NPH2,A6NDG6 227 3.24e-02 2154 10 5 0.500 0.002 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q9NPH2,P09972,P05026,P04075,A6NDG6 227 3.26e-02 798 10 3 0.300 0.004 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P09972,P05026,P04075 227 3.30e-02 162 10 2 0.200 0.012 GO:0031647 BP 1 regulation of protein stability 1 P05026,O96017 227 3.32e-02 44 10 2 0.200 0.045 TF:M06635_0 tf 1 Factor: znf607; motif: NCCTTGAAGGGM; match class: 0 1 Q8N335,A6NDG6 227 3.48e-02 10 10 1 0.100 0.100 GO:0046716 BP 1 muscle cell cellular homeostasis 1 P04075 227 3.48e-02 10 10 1 0.100 0.100 GO:1901018 BP 1 positive regulation of potassium ion transmembrane transporter activity 1 P05026 227 3.48e-02 10 10 1 0.100 0.100 GO:0030007 BP 1 cellular potassium ion homeostasis 1 P05026 227 3.48e-02 10 10 1 0.100 0.100 GO:0071436 BP 1 sodium ion export 1 P05026 227 3.54e-02 5629 10 9 0.900 0.002 GO:0044444 CC 1 cytoplasmic part 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P04075,Q8N335,O96017,A6NDG6 227 3.82e-02 8 10 1 0.100 0.125 HP:0001082 hp 1 Cholecystitis 1 P04075 227 3.82e-02 8 10 1 0.100 0.125 HP:0012438 hp 1 Abnormal gallbladder physiology 1 P04075 227 3.83e-02 11 10 1 0.100 0.091 GO:0046685 BP 1 response to arsenic-containing substance 1 Q9H4Y5 227 3.83e-02 11 10 1 0.100 0.091 GO:0023023 MF 1 MHC protein complex binding 1 P05026 227 3.83e-02 11 10 1 0.100 0.091 GO:0023026 MF 1 MHC class II protein complex binding 1 P05026 227 3.83e-02 11 10 1 0.100 0.091 GO:0031573 BP 1 intra-S DNA damage checkpoint 1 O96017 227 4.03e-02 1516 10 4 0.400 0.003 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 Q9H4Y5,Q14376,P05026,O96017 227 4.05e-02 180 10 2 0.200 0.011 GO:0042391 BP 1 regulation of membrane potential 1 P05026,Q8N335 227 4.10e-02 6377 10 9 0.900 0.001 HPA:021010 hpa 1 liver; bile duct cells 1 Q9H4Y5,Q9NPH2,P09972,Q14376,P52209,P05026,P04075,O96017,A6NDG6 227 4.12e-02 874 10 3 0.300 0.003 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q9NPH2,P05026,A6NDG6 227 4.18e-02 12 10 1 0.100 0.083 GO:1902307 BP 1 positive regulation of sodium ion transmembrane transport 1 P05026 227 4.18e-02 12 10 1 0.100 0.083 GO:0090075 BP 1 relaxation of muscle 1 P05026 227 4.18e-02 12 10 1 0.100 0.083 GO:0055075 BP 1 potassium ion homeostasis 1 P05026 227 4.18e-02 12 10 1 0.100 0.083 GO:0099622 BP 1 cardiac muscle cell membrane repolarization 1 P05026 227 4.29e-02 9 10 1 0.100 0.111 HP:0012272 hp 1 J wave 1 Q8N335 227 4.48e-02 4163 10 7 0.700 0.002 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 Q9H4Y5,Q14376,P52209,P05026,P04075,O96017,A6NDG6 227 4.50e-02 375 10 2 0.200 0.005 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P05026,A6NDG6 227 4.52e-02 572 10 3 0.300 0.005 GO:0044712 BP 1 single-organism catabolic process 1 P09972,Q14376,P04075 227 4.52e-02 13 10 1 0.100 0.077 GO:1901381 BP 1 positive regulation of potassium ion transmembrane transport 1 P05026 227 4.52e-02 13 10 1 0.100 0.077 GO:0098739 BP 1 import across plasma membrane 1 P05026 227 4.52e-02 13 10 1 0.100 0.077 GO:0070528 BP 1 protein kinase C signaling 1 Q8N335 227 4.52e-02 13 10 1 0.100 0.077 GO:1901021 BP 1 positive regulation of calcium ion transmembrane transporter activity 1 P05026 227 4.52e-02 13 10 1 0.100 0.077 GO:0001671 MF 1 ATPase activator activity 1 P05026 227 4.53e-02 191 10 2 0.200 0.010 GO:0006650 BP 1 glycerophospholipid metabolic process 1 Q8N335,A6NDG6 227 4.57e-02 1576 10 4 0.400 0.003 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P09972,P05026,P04075,A6NDG6 227 4.75e-02 10 10 1 0.100 0.100 HP:0011705 hp 1 First degree atrioventricular block 1 Q8N335 227 4.75e-02 10 10 1 0.100 0.100 HP:0012232 hp 1 Shortened QT interval 1 Q8N335 227 4.79e-02 1599 10 4 0.400 0.003 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 Q14376,P52209,P05026,O96017 227 4.94e-02 2395 10 5 0.500 0.002 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q9NPH2,P09972,P05026,P04075,A6NDG6 227 5.00e-02 77 10 2 0.200 0.026 REAC:70326 rea 1 Glucose metabolism 1 P09972,P04075 227 5.00e-02 6 10 1 0.100 0.167 CORUM:2236 cor 1 ASF1-histone containing complex 1 O96017 227 5.00e-02 319 10 4 0.400 0.013 MI:hsa-miR-218-1* mi 1 MI:hsa-miR-218-1* 1 Q9H4Y5,Q14376,P52209,O96017 227 5.00e-02 8 10 1 0.100 0.125 OMIM:145500 omi 1 HYPERTENSION, ESSENTIAL;;EHT 1 P05026 227 5.00e-02 86 10 2 0.200 0.023 HP:0000952 hp 1 Jaundice 1 Q14376,P04075 227 5.00e-02 62 10 2 0.200 0.032 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P09972,P04075 227 5.00e-02 201 10 2 0.200 0.010 GO:0015672 BP 1 monovalent inorganic cation transport 1 P05026,Q8N335 227 5.00e-02 592 10 4 0.400 0.007 TF:M00174_1 tf 1 Factor: AP-1; motif: NNTGACTCANN; match class: 1 1 Q9NPH2,P09972,P05026,P04075 227 5.00e-02 8 10 1 0.100 0.125 OMIM:176807 omi 1 PROSTATE CANCER 1 O96017 228 2.29e-03 610 2 2 1.000 0.003 TF:M03871_0 tf 1 Factor: GLI; motif: MCVNNGACCACCCAV; match class: 0 1 Q9HC97,Q6S8J3 228 2.73e-03 3 2 1 0.500 0.333 GO:0016494 MF 1 C-X-C chemokine receptor activity 1 Q9HC97 228 3.64e-03 4 2 1 0.500 0.250 GO:1901386 BP 1 negative regulation of voltage-gated calcium channel activity 1 Q9HC97 228 5.03e-03 903 2 2 1.000 0.002 TF:M00977_0 tf 1 Factor: EBF; motif: KTCCCYWGRGA; match class: 0 1 Q9HC97,Q6S8J3 228 5.67e-03 959 2 2 1.000 0.002 TF:M01817_1 tf 1 Factor: TEF-1; motif: GWGGAATGT; match class: 1 1 Q9HC97,Q6S8J3 228 6.38e-03 7 2 1 0.500 0.143 GO:0001637 MF 1 G-protein coupled chemoattractant receptor activity 1 Q9HC97 228 6.38e-03 7 2 1 0.500 0.143 GO:0004950 MF 1 chemokine receptor activity 1 Q9HC97 228 6.70e-03 1042 2 2 1.000 0.002 TF:M05847_0 tf 1 Factor: ZNF837; motif: NCCWMAWAAARM; match class: 0 1 Q9HC97,Q6S8J3 228 7.37e-03 47 2 1 0.500 0.021 TF:M00001_1 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 1 1 Q6S8J3 228 8.20e-03 9 2 1 0.500 0.111 GO:0070098 BP 1 chemokine-mediated signaling pathway 1 Q9HC97 228 9.11e-03 10 2 1 0.500 0.100 GO:0051482 BP 1 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway 1 Q9HC97 228 1.03e-02 1291 2 2 1.000 0.002 TF:M00071_0 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 0 1 Q9HC97,Q6S8J3 228 1.07e-02 68 2 1 0.500 0.015 TF:M05727_0 tf 1 Factor: ZNF674; motif: NGTTMAAAAAWA; match class: 0 1 Q6S8J3 228 1.09e-02 12 2 1 0.500 0.083 GO:1901385 BP 1 regulation of voltage-gated calcium channel activity 1 Q9HC97 228 1.18e-02 13 2 1 0.500 0.077 GO:0035025 BP 1 positive regulation of Rho protein signal transduction 1 Q9HC97 228 1.19e-02 76 2 1 0.500 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 Q6S8J3 228 1.35e-02 86 2 1 0.500 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 Q9HC97 228 1.37e-02 15 2 1 0.500 0.067 GO:1903170 BP 1 negative regulation of calcium ion transmembrane transport 1 Q9HC97 228 1.37e-02 15 2 1 0.500 0.067 GO:1901020 BP 1 negative regulation of calcium ion transmembrane transporter activity 1 Q9HC97 228 1.46e-02 16 2 1 0.500 0.062 GO:2001258 BP 1 negative regulation of cation channel activity 1 Q9HC97 228 1.64e-02 1632 2 2 1.000 0.001 TF:M03877_0 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 0 1 Q9HC97,Q6S8J3 228 1.71e-02 109 2 1 0.500 0.009 TF:M07098_1 tf 1 Factor: HNF-4gamma; motif: NNRGNNCAAAGKYCA; match class: 1 1 Q9HC97 228 1.72e-02 110 2 1 0.500 0.009 TF:M04058_0 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 0 1 Q9HC97 228 1.84e-02 1728 2 2 1.000 0.001 TF:M07351_0 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 0 1 Q9HC97,Q6S8J3 228 1.91e-02 21 2 1 0.500 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 Q9HC97 228 2.00e-02 22 2 1 0.500 0.045 GO:0046579 BP 1 positive regulation of Ras protein signal transduction 1 Q9HC97 228 2.09e-02 23 2 1 0.500 0.043 GO:0051057 BP 1 positive regulation of small GTPase mediated signal transduction 1 Q9HC97 228 2.09e-02 23 2 1 0.500 0.043 GO:0004896 MF 1 cytokine receptor activity 1 Q9HC97 228 2.28e-02 146 2 1 0.500 0.007 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 Q9HC97 228 2.42e-02 783 2 2 1.000 0.003 GO:0042592 BP 1 homeostatic process 1 Q9HC97,Q6S8J3 228 2.55e-02 28 2 1 0.500 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 Q9HC97 228 2.65e-02 170 2 1 0.500 0.006 TF:M06125_0 tf 1 Factor: ZNF823; motif: NGRGGGAGGAGG; match class: 0 1 Q6S8J3 228 2.67e-02 171 2 1 0.500 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q9HC97 228 2.73e-02 30 2 1 0.500 0.033 GO:1904063 BP 1 negative regulation of cation transmembrane transport 1 Q9HC97 228 2.82e-02 31 2 1 0.500 0.032 GO:0008528 MF 1 G-protein coupled peptide receptor activity 1 Q9HC97 228 2.91e-02 32 2 1 0.500 0.031 GO:0001653 MF 1 peptide receptor activity 1 Q9HC97 228 2.93e-02 188 2 1 0.500 0.005 TF:M03877_1 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 1 1 Q9HC97 228 3.00e-02 33 2 1 0.500 0.030 GO:0035023 BP 1 regulation of Rho protein signal transduction 1 Q9HC97 228 3.03e-02 2215 2 2 1.000 0.001 TF:M07341_1 tf 1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 1 Q9HC97,Q6S8J3 228 3.09e-02 34 2 1 0.500 0.029 GO:0021762 BP 1 substantia nigra development 1 Q6S8J3 228 3.18e-02 35 2 1 0.500 0.029 GO:0032410 BP 1 negative regulation of transporter activity 1 Q9HC97 228 3.27e-02 210 2 1 0.500 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 Q6S8J3 228 3.28e-02 36 2 1 0.500 0.028 GO:0048857 BP 1 neural nucleus development 1 Q6S8J3 228 3.28e-02 36 2 1 0.500 0.028 GO:0034766 BP 1 negative regulation of ion transmembrane transport 1 Q9HC97 228 3.28e-02 36 2 1 0.500 0.028 GO:0007200 BP 1 phospholipase C-activating G-protein coupled receptor signaling pathway 1 Q9HC97 228 3.37e-02 216 2 1 0.500 0.005 TF:M04190_0 tf 1 Factor: TCF3; motif: NRCACCTGNN; match class: 0 1 Q6S8J3 228 3.43e-02 220 2 1 0.500 0.005 TF:M00134_1 tf 1 Factor: HNF4; motif: NNNRGGNCAAAGKTCANNN; match class: 1 1 Q9HC97 228 3.46e-02 38 2 1 0.500 0.026 GO:0034763 BP 1 negative regulation of transmembrane transport 1 Q9HC97 228 3.55e-02 39 2 1 0.500 0.026 GO:1901019 BP 1 regulation of calcium ion transmembrane transporter activity 1 Q9HC97 228 3.58e-02 230 2 1 0.500 0.004 TF:M04364_0 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 0 1 Q9HC97 228 3.86e-02 248 2 1 0.500 0.004 TF:M03828_1 tf 1 Factor: HNF-4; motif: NNNNNNNGNNCAAAGKYCAN; match class: 1 1 Q9HC97 228 3.87e-02 249 2 1 0.500 0.004 TF:M07105_0 tf 1 Factor: JunD; motif: NNNRATGAYGTCATN; match class: 0 1 Q9HC97 228 3.89e-02 250 2 1 0.500 0.004 TF:M00464_0 tf 1 Factor: POU3F2; motif: TTATGYTAAT; match class: 0 1 Q6S8J3 228 3.91e-02 43 2 1 0.500 0.023 GO:0001895 BP 1 retina homeostasis 1 Q6S8J3 228 4.03e-02 259 2 1 0.500 0.004 TF:M00764_1 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 1 1 Q9HC97 228 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 Q6S8J3 228 4.38e-02 2664 2 2 1.000 0.001 TF:M01034_1 tf 1 Factor: Ebox; motif: NCACSTGNCN; match class: 1 1 Q9HC97,Q6S8J3 228 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 Q9HC97 228 4.64e-02 51 2 1 0.500 0.020 GO:0030901 BP 1 midbrain development 1 Q6S8J3 228 4.73e-02 52 2 1 0.500 0.019 GO:1903169 BP 1 regulation of calcium ion transmembrane transport 1 Q9HC97 228 4.73e-02 52 2 1 0.500 0.019 GO:0043271 BP 1 negative regulation of ion transport 1 Q9HC97 228 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q6S8J3 228 4.97e-02 320 2 1 0.500 0.003 TF:M06344_0 tf 1 Factor: ZNF530; motif: NGGGCAATWAYA; match class: 0 1 Q6S8J3 228 5.00e-02 107 2 1 0.500 0.009 KEGG:04080 keg 1 Neuroactive ligand-receptor interaction 1 Q9HC97 228 5.00e-02 55 2 1 0.500 0.018 GO:2001257 BP 1 regulation of cation channel activity 1 Q9HC97 228 5.00e-02 5 2 1 0.500 0.200 HP:0002611 hp 1 Cholestatic liver disease 1 Q9HC97 229 1.22e-03 1 2 1 0.500 1.000 GO:2000790 BP 1 regulation of mesenchymal cell proliferation involved in lung development 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0060486 BP 1 Clara cell differentiation 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:2000795 BP 1 negative regulation of epithelial cell proliferation involved in lung morphogenesis 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0060509 BP 1 Type I pneumocyte differentiation 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0021740 BP 1 principal sensory nucleus of trigeminal nerve development 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0061141 BP 1 lung ciliated cell differentiation 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0061140 BP 1 lung secretory cell differentiation 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0021960 BP 1 anterior commissure morphogenesis 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0060510 BP 1 Type II pneumocyte differentiation 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:0021730 BP 1 trigeminal sensory nucleus development 1 O00712 229 1.22e-03 1 2 1 0.500 1.000 GO:2000791 BP 1 negative regulation of mesenchymal cell proliferation involved in lung development 1 O00712 229 2.44e-03 2 2 1 0.500 0.500 GO:0044300 CC 1 cerebellar mossy fiber 1 O00712 229 2.44e-03 2 2 1 0.500 0.500 GO:0060916 BP 1 mesenchymal cell proliferation involved in lung development 1 O00712 229 3.34e-03 1 2 1 0.500 1.000 OMIM:616402 omi 1 MICROCEPHALY 14, PRIMARY, AUTOSOMAL RECESSIVE; MCPH14 1 Q6UVJ0 229 3.66e-03 3 2 1 0.500 0.333 GO:0060479 BP 1 lung cell differentiation 1 O00712 229 3.66e-03 3 2 1 0.500 0.333 GO:0072201 BP 1 negative regulation of mesenchymal cell proliferation 1 O00712 229 3.66e-03 3 2 1 0.500 0.333 GO:0060487 BP 1 lung epithelial cell differentiation 1 O00712 229 4.89e-03 4 2 1 0.500 0.250 GO:2000794 BP 1 regulation of epithelial cell proliferation involved in lung morphogenesis 1 O00712 229 4.89e-03 4 2 1 0.500 0.250 GO:0060502 BP 1 epithelial cell proliferation involved in lung morphogenesis 1 O00712 229 4.89e-03 4 2 1 0.500 0.250 GO:0098536 CC 1 deuterosome 1 Q6UVJ0 229 6.11e-03 5 2 1 0.500 0.200 GO:0071679 BP 1 commissural neuron axon guidance 1 O00712 229 7.33e-03 6 2 1 0.500 0.167 GO:1902894 BP 1 negative regulation of pri-miRNA transcription from RNA polymerase II promoter 1 O00712 229 8.55e-03 7 2 1 0.500 0.143 GO:0021952 BP 1 central nervous system projection neuron axonogenesis 1 O00712 229 1.08e-02 21 2 1 0.500 0.048 REAC:73980 rea 1 RNA Polymerase III Transcription Termination 1 O00712 229 1.10e-02 9 2 1 0.500 0.111 GO:0060428 BP 1 lung epithelium development 1 O00712 229 1.10e-02 9 2 1 0.500 0.111 GO:0021955 BP 1 central nervous system neuron axonogenesis 1 O00712 229 1.10e-02 9 2 1 0.500 0.111 GO:0060425 BP 1 lung morphogenesis 1 O00712 229 1.47e-02 12 2 1 0.500 0.083 GO:0010464 BP 1 regulation of mesenchymal cell proliferation 1 O00712 229 1.71e-02 14 2 1 0.500 0.071 GO:0010463 BP 1 mesenchymal cell proliferation 1 O00712 229 1.90e-02 37 2 1 0.500 0.027 REAC:74158 rea 1 RNA Polymerase III Transcription 1 O00712 229 1.90e-02 37 2 1 0.500 0.027 REAC:749476 rea 1 RNA Polymerase III Abortive And Retractive Initiation 1 O00712 229 2.08e-02 17 2 1 0.500 0.059 GO:0061614 BP 1 pri-miRNA transcription from RNA polymerase II promoter 1 O00712 229 2.08e-02 17 2 1 0.500 0.059 GO:1902893 BP 1 regulation of pri-miRNA transcription from RNA polymerase II promoter 1 O00712 229 2.37e-02 1663 2 2 1.000 0.001 HPA:004010_02 hpa 1 breast; adipocytes[Uncertain,Medium] 1 O00712,Q6UVJ0 229 2.81e-02 23 2 1 0.500 0.043 GO:0021954 BP 1 central nervous system neuron development 1 O00712 229 3.29e-02 27 2 1 0.500 0.037 GO:0007099 BP 1 centriole replication 1 Q6UVJ0 229 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 O00712,Q6UVJ0 229 3.42e-02 28 2 1 0.500 0.036 GO:0030324 BP 1 lung development 1 O00712 229 3.42e-02 28 2 1 0.500 0.036 GO:0098534 BP 1 centriole assembly 1 Q6UVJ0 229 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 O00712,Q6UVJ0 229 3.66e-02 30 2 1 0.500 0.033 GO:0030323 BP 1 respiratory tube development 1 O00712 229 3.90e-02 32 2 1 0.500 0.031 GO:0002062 BP 1 chondrocyte differentiation 1 O00712 229 4.10e-02 420 2 2 1.000 0.005 MI:hsa-miR-302d mi 1 MI:hsa-miR-302d 1 O00712,Q6UVJ0 229 4.12e-02 14 2 1 0.500 0.071 HP:0002472 hp 1 Small cerebral cortex 1 Q6UVJ0 229 4.12e-02 14 2 1 0.500 0.071 HP:0011019 hp 1 Abnormality of chromosome condensation 1 Q6UVJ0 229 4.12e-02 14 2 1 0.500 0.071 HP:0003451 hp 1 Increased rate of premature chromosome condensation 1 Q6UVJ0 229 4.39e-02 36 2 1 0.500 0.028 GO:0048857 BP 1 neural nucleus development 1 O00712 229 4.51e-02 37 2 1 0.500 0.027 GO:0060541 BP 1 respiratory system development 1 O00712 229 4.60e-02 445 2 2 1.000 0.004 MI:hsa-miR-302a mi 1 MI:hsa-miR-302a 1 O00712,Q6UVJ0 229 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 O00712,Q6UVJ0 229 4.91e-02 460 2 2 1.000 0.004 MI:hsa-miR-302b mi 1 MI:hsa-miR-302b 1 O00712,Q6UVJ0 229 5.00e-02 41 2 1 0.500 0.024 GO:0010001 BP 1 glial cell differentiation 1 O00712 229 5.00e-02 3 2 1 0.500 0.333 TF:M05325_1 tf 1 Factor: Tbx3; motif: AGGTGTGAAAT; match class: 1 1 Q6UVJ0 229 5.00e-02 17 2 1 0.500 0.059 HP:0010636 hp 1 Schizencephaly 1 Q6UVJ0 229 5.00e-02 464 2 2 1.000 0.004 MI:hsa-miR-517c mi 1 MI:hsa-miR-517c 1 O00712,Q6UVJ0 229 5.00e-02 3 2 1 0.500 0.333 TF:M05365_1 tf 1 Factor: TBX2; motif: AGGTGTGAAAT; match class: 1 1 Q6UVJ0 229 5.00e-02 98 2 1 0.500 0.010 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 O00712 230 1.48e-03 1 4 1 0.250 1.000 GO:0001680 BP 1 tRNA 3'-terminal CCA addition 1 Q96Q11 230 1.48e-03 1 4 1 0.250 1.000 GO:0004810 MF 1 tRNA adenylyltransferase activity 1 Q96Q11 230 1.48e-03 1 4 1 0.250 1.000 GO:1990180 BP 1 mitochondrial tRNA 3'-end processing 1 Q96Q11 230 1.48e-03 1 4 1 0.250 1.000 GO:0052657 MF 1 guanine phosphoribosyltransferase activity 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0004422 MF 1 hypoxanthine phosphoribosyltransferase activity 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0046099 BP 1 guanine biosynthetic process 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0033240 BP 1 positive regulation of cellular amine metabolic process 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0006166 BP 1 purine ribonucleoside salvage 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0046038 BP 1 GMP catabolic process 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0032263 BP 1 GMP salvage 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0006168 BP 1 adenine salvage 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0032264 BP 1 IMP salvage 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0006177 BP 1 GMP biosynthetic process 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0006178 BP 1 guanine salvage 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0045915 BP 1 positive regulation of catecholamine metabolic process 1 P00492 230 2.95e-03 2 4 1 0.250 0.500 GO:0045964 BP 1 positive regulation of dopamine metabolic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0032261 BP 1 purine nucleotide salvage 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0046083 BP 1 adenine metabolic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0046037 BP 1 GMP metabolic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0000965 BP 1 mitochondrial RNA 3'-end processing 1 Q96Q11 230 4.43e-03 3 4 1 0.250 0.333 GO:0042780 BP 1 tRNA 3'-end processing 1 Q96Q11 230 4.43e-03 3 4 1 0.250 0.333 GO:0046098 BP 1 guanine metabolic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:1901069 BP 1 guanosine-containing compound catabolic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0046084 BP 1 adenine biosynthetic process 1 P00492 230 4.43e-03 3 4 1 0.250 0.333 GO:0043173 BP 1 nucleotide salvage 1 P00492 230 5.91e-03 4 4 1 0.250 0.250 GO:0042069 BP 1 regulation of catecholamine metabolic process 1 P00492 230 5.91e-03 4 4 1 0.250 0.250 GO:1901070 BP 1 guanosine-containing compound biosynthetic process 1 P00492 230 5.91e-03 4 4 1 0.250 0.250 GO:0042053 BP 1 regulation of dopamine metabolic process 1 P00492 230 5.91e-03 4 4 1 0.250 0.250 GO:0043103 BP 1 hypoxanthine salvage 1 P00492 230 7.17e-03 1 4 1 0.250 1.000 OMIM:300323 omi 1 KELLEY-SEEGMILLER SYNDROME;;GOUT, HPRT-RELATED;;HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 1 DEFICIENCY, PARTIAL;;HPRT DEFICIENCY, PARTIAL;;HPRT1 DEFICIENCY, PARTIAL 1 P00492 230 7.17e-03 1 4 1 0.250 1.000 OMIM:616084 omi 1 SIDEROBLASTIC ANEMIA WITH B-CELL IMMUNODEFICIENCY, PERIODIC FEVERS,AND DEVELOPMENTAL DELAY; SIFD 1 Q96Q11 230 7.17e-03 1 4 1 0.250 1.000 OMIM:300322 omi 1 LESCH-NYHAN SYNDROME; LNS;;HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 1 DEFICIENCY;;HPRT1 DEFICIENCY;;HPRT DEFICIENCY;;HPRT DEFICIENCY, COMPLETEHPRT DEFICIENCY, NEUROLOGIC VARIANT, INCLUDED;;LESCH-NYHAN SYNDROME, NEUROLOGIC VARIANT, INCLUDED 1 P00492 230 7.38e-03 5 4 1 0.250 0.200 GO:0004301 MF 1 epoxide hydrolase activity 1 Q9H4A4 230 7.38e-03 5 4 1 0.250 0.200 GO:0046101 BP 1 hypoxanthine biosynthetic process 1 P00492 230 7.38e-03 5 4 1 0.250 0.200 GO:0043096 BP 1 purine nucleobase salvage 1 P00492 230 7.38e-03 5 4 1 0.250 0.200 GO:0006188 BP 1 IMP biosynthetic process 1 P00492 230 8.86e-03 6 4 1 0.250 0.167 GO:0009158 BP 1 ribonucleoside monophosphate catabolic process 1 P00492 230 8.86e-03 6 4 1 0.250 0.167 GO:0016803 MF 1 ether hydrolase activity 1 Q9H4A4 230 8.86e-03 6 4 1 0.250 0.167 GO:0009128 BP 1 purine nucleoside monophosphate catabolic process 1 P00492 230 8.86e-03 6 4 1 0.250 0.167 GO:0009169 BP 1 purine ribonucleoside monophosphate catabolic process 1 P00492 230 8.86e-03 6 4 1 0.250 0.167 GO:0046100 BP 1 hypoxanthine metabolic process 1 P00492 230 9.47e-03 1 4 1 0.250 1.000 HP:0001854 hp 1 Podagra 1 P00492 230 1.03e-02 7 4 1 0.250 0.143 GO:0009125 BP 1 nucleoside monophosphate catabolic process 1 P00492 230 1.18e-02 8 4 1 0.250 0.125 GO:0046040 BP 1 IMP metabolic process 1 P00492 230 1.31e-02 266 4 2 0.500 0.008 GO:1901565 BP 1 organonitrogen compound catabolic process 1 P00492,Q9H4A4 230 1.33e-02 9 4 1 0.250 0.111 GO:0016801 MF 1 hydrolase activity, acting on ether bonds 1 Q9H4A4 230 1.33e-02 9 4 1 0.250 0.111 GO:0009113 BP 1 purine nucleobase biosynthetic process 1 P00492 230 1.62e-02 11 4 1 0.250 0.091 GO:0045776 BP 1 negative regulation of blood pressure 1 Q9H4A4 230 1.62e-02 11 4 1 0.250 0.091 GO:0090646 BP 1 mitochondrial tRNA processing 1 Q96Q11 230 1.77e-02 12 4 1 0.250 0.083 GO:0006152 BP 1 purine nucleoside catabolic process 1 P00492 230 1.77e-02 12 4 1 0.250 0.083 GO:0046112 BP 1 nucleobase biosynthetic process 1 P00492 230 1.77e-02 12 4 1 0.250 0.083 GO:0046130 BP 1 purine ribonucleoside catabolic process 1 P00492 230 1.92e-02 4019 4 4 1.000 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.06e-02 14 4 1 0.250 0.071 GO:0006144 BP 1 purine nucleobase metabolic process 1 P00492 230 2.06e-02 14 4 1 0.250 0.071 GO:0043174 BP 1 nucleoside salvage 1 P00492 230 2.06e-02 14 4 1 0.250 0.071 GO:0070006 MF 1 metalloaminopeptidase activity 1 Q9H4A4 230 2.06e-02 14 4 1 0.250 0.071 GO:0000963 BP 1 mitochondrial RNA processing 1 Q96Q11 230 2.18e-02 1291 4 3 0.750 0.002 GO:0043167 MF 1 ion binding 1 Q96Q11,P00492,Q9H4A4 230 2.21e-02 4163 4 4 1.000 0.001 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.21e-02 15 4 1 0.250 0.067 GO:0043101 BP 1 purine-containing compound salvage 1 P00492 230 2.21e-02 15 4 1 0.250 0.067 GO:0042417 BP 1 dopamine metabolic process 1 P00492 230 2.21e-02 15 4 1 0.250 0.067 GO:0042454 BP 1 ribonucleoside catabolic process 1 P00492 230 2.34e-02 4225 4 4 1.000 0.001 HPA:046010_02 hpa 1 tonsil; germinal center cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.37e-02 4237 4 4 1.000 0.001 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.53e-02 4308 4 4 1.000 0.001 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.65e-02 18 4 1 0.250 0.056 GO:1901068 BP 1 guanosine-containing compound metabolic process 1 P00492 230 2.65e-02 18 4 1 0.250 0.056 GO:0043171 BP 1 peptide catabolic process 1 Q9H4A4 230 2.78e-02 4407 4 4 1.000 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 2.80e-02 19 4 1 0.250 0.053 GO:0070566 MF 1 adenylyltransferase activity 1 Q96Q11 230 2.84e-02 3 4 1 0.250 0.333 HP:0003149 hp 1 Hyperuricosuria 1 P00492 230 2.95e-02 20 4 1 0.250 0.050 GO:0009154 BP 1 purine ribonucleotide catabolic process 1 P00492 230 2.96e-02 798 4 2 0.500 0.003 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 Q9BSH4,P00492 230 2.99e-02 4491 4 4 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 3.09e-02 21 4 1 0.250 0.048 GO:0006584 BP 1 catecholamine metabolic process 1 P00492 230 3.09e-02 21 4 1 0.250 0.048 GO:0009261 BP 1 ribonucleotide catabolic process 1 P00492 230 3.09e-02 21 4 1 0.250 0.048 GO:0043628 BP 1 ncRNA 3'-end processing 1 Q96Q11 230 3.09e-02 21 4 1 0.250 0.048 GO:0009712 BP 1 catechol-containing compound metabolic process 1 P00492 230 3.14e-02 79 4 2 0.500 0.025 HP:0010972 hp 1 Anemia of inadequate production 1 Q96Q11,P00492 230 3.47e-02 4659 4 4 1.000 0.001 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492,Q9H4A4 230 3.53e-02 24 4 1 0.250 0.042 GO:0009112 BP 1 nucleobase metabolic process 1 P00492 230 3.63e-02 2392 4 3 0.750 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q96Q11,Q9BSH4,P00492 230 3.68e-02 750 4 3 0.750 0.004 TF:M01127_1 tf 1 Factor: islet1; motif: GSNTAATRK; match class: 1 1 Q96Q11,P00492,Q9H4A4 230 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q9BSH4,P00492 230 3.92e-02 321 4 3 0.750 0.009 HP:0001903 hp 1 Anemia 1 Q96Q11,Q9BSH4,P00492 230 3.97e-02 27 4 1 0.250 0.037 GO:0009164 BP 1 nucleoside catabolic process 1 P00492 230 4.27e-02 29 4 1 0.250 0.034 GO:0046148 BP 1 pigment biosynthetic process 1 P00492 230 4.27e-02 29 4 1 0.250 0.034 GO:0000049 MF 1 tRNA binding 1 Q96Q11 230 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q9BSH4,P00492 230 4.41e-02 30 4 1 0.250 0.033 GO:0000959 BP 1 mitochondrial RNA metabolic process 1 Q96Q11 230 4.56e-02 31 4 1 0.250 0.032 GO:0004177 MF 1 aminopeptidase activity 1 Q9H4A4 230 4.71e-02 32 4 1 0.250 0.031 GO:0006195 BP 1 purine nucleotide catabolic process 1 P00492 230 4.71e-02 32 4 1 0.250 0.031 GO:1901658 BP 1 glycosyl compound catabolic process 1 P00492 230 4.73e-02 5 4 1 0.250 0.200 HP:0001997 hp 1 Gout 1 P00492 230 5.00e-02 832 4 3 0.750 0.004 TF:M03969_1 tf 1 Factor: ELF5; motif: ANSMGGAAGTN; match class: 1 1 Q96Q11,P00492,Q9H4A4 230 5.00e-02 7 4 1 0.250 0.143 OMIM:220110 omi 1 MITOCHONDRIAL COMPLEX IV DEFICIENCY;;CYTOCHROME c OXIDASE DEFICIENCY;;COX DEFICIENCY 1 Q9BSH4 230 5.00e-02 498 4 3 0.750 0.006 MI:hsa-miR-125a-3p mi 1 MI:hsa-miR-125a-3p 1 Q96Q11,Q9BSH4,P00492 230 5.00e-02 349 4 3 0.750 0.009 HP:0001877 hp 1 Abnormality of erythrocytes 1 Q96Q11,Q9BSH4,P00492 230 5.00e-02 35 4 1 0.250 0.029 KEGG:00983 keg 1 Drug metabolism - other enzymes 1 P00492 230 5.00e-02 12 4 1 0.250 0.083 REAC:74217 rea 1 Purine salvage 1 P00492 230 5.00e-02 349 4 3 0.750 0.009 HP:0012130 hp 1 Abnormality of cells of the erythroid lineage 1 Q96Q11,Q9BSH4,P00492 231 1.48e-04 90 2 2 1.000 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Q9BPX1,Q00796 231 1.76e-04 98 2 2 1.000 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 Q9BPX1,Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0031320 MF 1 hexitol dehydrogenase activity 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0006062 BP 1 sorbitol catabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0051160 BP 1 L-xylitol catabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0019519 BP 1 pentitol metabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0046526 MF 1 D-xylulose reductase activity 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0019527 BP 1 pentitol catabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0051164 BP 1 L-xylitol metabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0003939 MF 1 L-iditol 2-dehydrogenase activity 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0006060 BP 1 sorbitol metabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0019407 BP 1 hexitol catabolic process 1 Q00796 231 4.26e-04 1 2 1 0.500 1.000 GO:0006059 BP 1 hexitol metabolic process 1 Q00796 231 5.54e-04 2 2 1 0.500 0.500 REAC:5652227 rea 1 Fructose biosynthesis 1 Q00796 231 8.52e-04 2 2 1 0.500 0.500 GO:0046370 BP 1 fructose biosynthetic process 1 Q00796 231 8.52e-04 2 2 1 0.500 0.500 GO:0019405 BP 1 alditol catabolic process 1 Q00796 231 8.52e-04 2 2 1 0.500 0.500 GO:0047045 MF 1 testosterone 17-beta-dehydrogenase (NADP+) activity 1 Q9BPX1 231 1.11e-03 4 2 1 0.500 0.250 REAC:193144 rea 1 Estrogen biosynthesis 1 Q9BPX1 231 1.38e-03 5 2 1 0.500 0.200 REAC:5661270 rea 1 Catabolism of glucuronate to xylulose-5-phosphate 1 Q00796 231 1.66e-03 6 2 1 0.500 0.167 REAC:5652084 rea 1 Fructose metabolism 1 Q00796 231 2.13e-03 5 2 1 0.500 0.200 GO:0006064 BP 1 glucuronate catabolic process 1 Q00796 231 2.13e-03 5 2 1 0.500 0.200 GO:0051167 BP 1 xylulose 5-phosphate metabolic process 1 Q00796 231 2.13e-03 5 2 1 0.500 0.200 GO:0019640 BP 1 glucuronate catabolic process to xylulose 5-phosphate 1 Q00796 231 2.13e-03 5 2 1 0.500 0.200 GO:1901159 BP 1 xylulose 5-phosphate biosynthetic process 1 Q00796 231 2.13e-03 5 2 1 0.500 0.200 GO:0006703 BP 1 estrogen biosynthetic process 1 Q9BPX1 231 2.55e-03 6 2 1 0.500 0.167 GO:0004303 MF 1 estradiol 17-beta-dehydrogenase activity 1 Q9BPX1 231 2.83e-03 18 2 1 0.500 0.056 TF:M04215_0 tf 1 Factor: MAFF; motif: NTGCTGASTCAGCAW; match class: 0 1 Q00796 231 3.83e-03 9 2 1 0.500 0.111 GO:0019400 BP 1 alditol metabolic process 1 Q00796 231 4.24e-03 480 2 2 1.000 0.004 GO:0016491 MF 1 oxidoreductase activity 1 Q9BPX1,Q00796 231 4.26e-03 10 2 1 0.500 0.100 GO:0008210 BP 1 estrogen metabolic process 1 Q9BPX1 231 4.68e-03 11 2 1 0.500 0.091 GO:0046174 BP 1 polyol catabolic process 1 Q00796 231 4.68e-03 11 2 1 0.500 0.091 GO:0006000 BP 1 fructose metabolic process 1 Q00796 231 4.68e-03 11 2 1 0.500 0.091 GO:0006706 BP 1 steroid catabolic process 1 Q9BPX1 231 4.70e-03 17 2 1 0.500 0.059 REAC:196071 rea 1 Metabolism of steroid hormones 1 Q9BPX1 231 5.02e-03 32 2 1 0.500 0.031 TF:M06667_0 tf 1 Factor: ZNF599; motif: KGGTTCAGGAGM; match class: 0 1 Q9BPX1 231 6.03e-03 572 2 2 1.000 0.003 GO:0044712 BP 1 single-organism catabolic process 1 Q9BPX1,Q00796 231 6.38e-03 15 2 1 0.500 0.067 GO:0051287 MF 1 NAD binding 1 Q00796 231 6.75e-03 43 2 1 0.500 0.023 TF:M05637_0 tf 1 Factor: ZNF189; motif: KGTTGSGGGATY; match class: 0 1 Q00796 231 7.24e-03 17 2 1 0.500 0.059 GO:0033764 MF 1 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Q9BPX1 231 7.66e-03 18 2 1 0.500 0.056 GO:0016229 MF 1 steroid dehydrogenase activity 1 Q9BPX1 231 8.15e-03 52 2 1 0.500 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 Q00796 231 8.94e-03 21 2 1 0.500 0.048 GO:0046164 BP 1 alcohol catabolic process 1 Q00796 231 9.09e-03 58 2 1 0.500 0.017 TF:M05970_1 tf 1 Factor: Zipro1; motif: NTGAAGGAGGM; match class: 1 1 Q9BPX1 231 9.36e-03 22 2 1 0.500 0.045 GO:0006063 BP 1 uronic acid metabolic process 1 Q00796 231 9.36e-03 22 2 1 0.500 0.045 GO:0019585 BP 1 glucuronate metabolic process 1 Q00796 231 1.02e-02 24 2 1 0.500 0.042 GO:0030317 BP 1 flagellated sperm motility 1 Q00796 231 1.02e-02 24 2 1 0.500 0.042 GO:0097722 BP 1 sperm motility 1 Q00796 231 1.11e-02 26 2 1 0.500 0.038 GO:1901616 BP 1 organic hydroxy compound catabolic process 1 Q00796 231 1.15e-02 27 2 1 0.500 0.037 GO:0042446 BP 1 hormone biosynthetic process 1 Q9BPX1 231 1.15e-02 27 2 1 0.500 0.037 GO:0044275 BP 1 cellular carbohydrate catabolic process 1 Q00796 231 1.20e-02 1395 2 2 1.000 0.001 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q9BPX1,Q00796 231 1.35e-02 86 2 1 0.500 0.012 TF:M06108_0 tf 1 Factor: ZNF43; motif: NCTKGTTGGTGM; match class: 0 1 Q00796 231 1.93e-02 1767 2 2 1.000 0.001 TF:M00978_0 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 0 1 Q9BPX1,Q00796 231 2.00e-02 47 2 1 0.500 0.021 GO:0034754 BP 1 cellular hormone metabolic process 1 Q9BPX1 231 2.17e-02 139 2 1 0.500 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q00796 231 2.21e-02 52 2 1 0.500 0.019 GO:0046365 BP 1 monosaccharide catabolic process 1 Q00796 231 2.21e-02 52 2 1 0.500 0.019 GO:0031514 CC 1 motile cilium 1 Q00796 231 2.21e-02 52 2 1 0.500 0.019 GO:0030246 MF 1 carbohydrate binding 1 Q00796 231 2.29e-02 54 2 1 0.500 0.019 GO:0019319 BP 1 hexose biosynthetic process 1 Q00796 231 2.46e-02 58 2 1 0.500 0.017 GO:0046364 BP 1 monosaccharide biosynthetic process 1 Q00796 231 2.59e-02 61 2 1 0.500 0.016 GO:0019751 BP 1 polyol metabolic process 1 Q00796 231 2.64e-02 2068 2 2 1.000 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 Q9BPX1,Q00796 231 2.72e-02 2099 2 2 1.000 0.001 TF:M07376_0 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 0 1 Q9BPX1,Q00796 231 2.96e-02 2189 2 2 1.000 0.001 TF:M00322_0 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 0 1 Q9BPX1,Q00796 231 3.07e-02 1290 2 2 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 Q9BPX1,Q00796 231 3.20e-02 205 2 1 0.500 0.005 TF:M07376_1 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 1 1 Q00796 231 3.40e-02 80 2 1 0.500 0.013 GO:0042445 BP 1 hormone metabolic process 1 Q9BPX1 231 3.42e-02 1362 2 2 1.000 0.001 GO:0009056 BP 1 catabolic process 1 Q9BPX1,Q00796 231 3.48e-02 82 2 1 0.500 0.012 GO:0072329 BP 1 monocarboxylic acid catabolic process 1 Q00796 231 3.50e-02 225 2 1 0.500 0.004 TF:M00191_1 tf 1 Factor: ER; motif: NNARGNCANNNTGACCYNN; match class: 1 1 Q9BPX1 231 3.61e-02 85 2 1 0.500 0.012 GO:0050662 MF 1 coenzyme binding 1 Q00796 231 3.79e-02 2478 2 2 1.000 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q9BPX1,Q00796 231 3.92e-02 2521 2 2 1.000 0.001 TF:M05883_0 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 0 1 Q9BPX1,Q00796 231 4.11e-02 97 2 1 0.500 0.010 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 Q00796 231 4.33e-02 102 2 1 0.500 0.010 GO:0016052 BP 1 carbohydrate catabolic process 1 Q00796 231 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 Q9BPX1 231 4.53e-02 2710 2 2 1.000 0.001 TF:M02019_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q9BPX1,Q00796 231 4.53e-02 2710 2 2 1.000 0.001 TF:M03794_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q9BPX1,Q00796 231 4.64e-02 299 2 1 0.500 0.003 TF:M05619_0 tf 1 Factor: ZSCAN5C; motif: NMGTTWAACATG; match class: 0 1 Q9BPX1 231 4.66e-02 110 2 1 0.500 0.009 GO:0006006 BP 1 glucose metabolic process 1 Q00796 231 4.77e-02 307 2 1 0.500 0.003 TF:M06527_0 tf 1 Factor: ZNF675; motif: TGAAAGGGGA; match class: 0 1 Q9BPX1 231 4.87e-02 115 2 1 0.500 0.009 GO:0016051 BP 1 carbohydrate biosynthetic process 1 Q00796 231 4.95e-02 319 2 1 0.500 0.003 TF:M01830_0 tf 1 Factor: MAX; motif: CNNGMCACGTGN; match class: 0 1 Q00796 231 4.98e-02 321 2 1 0.500 0.003 TF:M04342_0 tf 1 Factor: HOXA13; motif: NCTCGTAAAAN; match class: 0 1 Q9BPX1 231 5.00e-02 118 2 1 0.500 0.008 GO:0048037 MF 1 cofactor binding 1 Q00796 231 5.00e-02 25 2 1 0.500 0.040 KEGG:00040 keg 1 Pentose and glucuronate interconversions 1 Q00796 232 8.71e-04 331 2 2 1.000 0.006 MI:hsa-miR-493* mi 1 MI:hsa-miR-493* 1 Q4VXU2,Q9H074 232 1.38e-03 152 2 2 1.000 0.013 KEGG:03013 keg 1 RNA transport 1 Q4VXU2,Q9H074 232 1.41e-03 9 2 1 0.500 0.111 TF:M06401_0 tf 1 Factor: ZNF551; motif: KGGTCCTAAATM; match class: 0 1 Q4VXU2 232 2.58e-03 647 2 2 1.000 0.003 TF:M03545_1 tf 1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 1 Q4VXU2,Q9H074 232 3.14e-03 20 2 1 0.500 0.050 TF:M06488_0 tf 1 Factor: ZNF595; motif: NGGGAGGGMWTC; match class: 0 1 Q9H074 232 5.52e-03 946 2 2 1.000 0.002 TF:M00729_1 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 1 1 Q4VXU2,Q9H074 232 1.08e-02 69 2 1 0.500 0.014 TF:M01719_1 tf 1 Factor: OTX2; motif: NRANGGATTARNN; match class: 1 1 Q9H074 232 1.08e-02 69 2 1 0.500 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 Q4VXU2 232 1.21e-02 77 2 1 0.500 0.013 TF:M05715_0 tf 1 Factor: ZNF133; motif: KGGTAAAAAAAA; match class: 0 1 Q9H074 232 1.22e-02 78 2 1 0.500 0.013 TF:M05949_0 tf 1 Factor: ZNF714; motif: NGGGAAGGAAGM; match class: 0 1 Q9H074 232 1.35e-02 86 2 1 0.500 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 Q4VXU2 232 1.42e-02 91 2 1 0.500 0.011 TF:M05748_0 tf 1 Factor: ZNF697; motif: NTGGGCRTCGGC; match class: 0 1 Q4VXU2 232 1.60e-02 1610 2 2 1.000 0.001 TF:M03563_1 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 1 Q4VXU2,Q9H074 232 1.71e-02 1665 2 2 1.000 0.001 TF:M01224_0 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 0 1 Q4VXU2,Q9H074 232 2.11e-02 135 2 1 0.500 0.007 TF:M01224_1 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 1 Q9H074 232 2.13e-02 23 2 1 0.500 0.043 REAC:429947 rea 1 Deadenylation of mRNA 1 Q9H074 232 2.31e-02 148 2 1 0.500 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 Q4VXU2 232 2.47e-02 2000 2 2 1.000 0.001 TF:M01692_1 tf 1 Factor: LTF; motif: GKVACTTNC; match class: 1 1 Q4VXU2,Q9H074 232 2.48e-02 159 2 1 0.500 0.006 TF:M06290_0 tf 1 Factor: Cos52; motif: NGGTCCDCCWGW; match class: 0 1 Q4VXU2 232 2.73e-02 2104 2 2 1.000 0.001 TF:M02098_0 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 0 1 Q4VXU2,Q9H074 232 3.38e-02 217 2 1 0.500 0.005 TF:M06534_0 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 0 1 Q4VXU2 232 3.40e-02 218 2 1 0.500 0.005 TF:M00152_0 tf 1 Factor: SRF; motif: ATGCCCATATATGGWNNT; match class: 0 1 Q4VXU2 232 3.47e-02 223 2 1 0.500 0.004 TF:M06677_0 tf 1 Factor: ZNF285; motif: NGTTCMKAAAGM; match class: 0 1 Q4VXU2 232 3.60e-02 231 2 1 0.500 0.004 TF:M06279_0 tf 1 Factor: ZNF124; motif: WGGCGTCAGA; match class: 0 1 Q9H074 232 3.94e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 Q4VXU2,Q9H074 232 4.09e-02 263 2 1 0.500 0.004 TF:M06419_0 tf 1 Factor: ZNF493; motif: NGKTAYKGGMGA; match class: 0 1 Q4VXU2 232 4.28e-02 71 2 1 0.500 0.014 KEGG:03018 keg 1 RNA degradation 1 Q4VXU2 232 4.49e-02 2697 2 2 1.000 0.001 TF:M07046_0 tf 1 Factor: LEF-1; motif: ANNWWCAAAGN; match class: 0 1 Q4VXU2,Q9H074 232 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 Q4VXU2 232 4.62e-02 2737 2 2 1.000 0.001 TF:M01255_0 tf 1 Factor: ipf1; motif: RNWCATTAANWN; match class: 0 1 Q4VXU2,Q9H074 232 4.75e-02 306 2 1 0.500 0.003 TF:M03874_0 tf 1 Factor: Hoxa9; motif: ATYAATDACATC; match class: 0 1 Q9H074 232 4.78e-02 308 2 1 0.500 0.003 TF:M07305_1 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 1 1 Q4VXU2 232 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 Q9H074 232 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q4VXU2,Q9H074 232 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q4VXU2 232 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q4VXU2 232 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q4VXU2,Q9H074 232 5.00e-02 5 2 1 0.500 0.200 GO:0008494 MF 1 translation activator activity 1 Q9H074 232 5.00e-02 5 2 1 0.500 0.200 CORUM:1307 cor 1 Multiprotein complex (mRNA turnover) 1 Q9H074 232 5.00e-02 54 2 1 0.500 0.019 REAC:429914 rea 1 Deadenylation-dependent mRNA decay 1 Q9H074 232 5.00e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 Q4VXU2 233 3.05e-14 306 29 14 0.483 0.046 GO:0015629 CC 1 actin cytoskeleton 1 Q9UHB6,O14974,O60237,Q14247,Q69YQ0,O60292,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y4I1,P07951 233 8.51e-14 419 29 15 0.517 0.036 GO:0030029 BP 1 actin filament-based process 1 Q14126,Q9UHB6,Q14247,Q69YQ0,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,Q9Y4I1,O43166,P07951 233 1.90e-10 358 29 12 0.414 0.034 GO:0030036 BP 1 actin cytoskeleton organization 1 Q9UHB6,Q14247,Q69YQ0,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,O43166 233 1.91e-10 1204 29 18 0.621 0.015 GO:0005856 CC 1 cytoskeleton 1 Q9UHB6,O14974,P60709,O60237,Q14247,Q69YQ0,O60292,Q92828,Q16643,Q32MZ4,Q5M775,Q5TB80,Q9NYL9,P68133,P06396,Q13045,Q9Y4I1,P07951 233 6.76e-09 758 29 14 0.483 0.018 GO:0007010 BP 1 cytoskeleton organization 1 Q9UHB6,O14974,Q14247,Q69YQ0,O60292,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,O43166 233 1.01e-07 933 29 14 0.483 0.015 GO:0044430 CC 1 cytoskeletal part 1 Q9UHB6,O14974,Q14247,Q69YQ0,O60292,Q16643,Q5M775,Q5TB80,Q9NYL9,P68133,P06396,Q13045,Q9Y4I1,P07951 233 1.32e-07 190 29 8 0.276 0.042 GO:0003012 BP 1 muscle system process 1 Q14126,O60237,Q14247,Q9NYL9,P68133,P06396,O43293,P07951 233 4.26e-07 83 29 6 0.207 0.072 GO:0030017 CC 1 sarcomere 1 O14974,O60237,Q9NYL9,P68133,Q9Y281,P07951 233 9.01e-07 94 29 6 0.207 0.064 GO:0030016 CC 1 myofibril 1 O14974,O60237,Q9NYL9,P68133,Q9Y281,P07951 233 9.60e-07 95 29 6 0.207 0.063 GO:0044449 CC 1 contractile fiber part 1 O14974,O60237,Q9NYL9,P68133,Q9Y281,P07951 233 1.10e-06 164 29 7 0.241 0.043 GO:0006936 BP 1 muscle contraction 1 Q14126,O60237,Q14247,Q9NYL9,P68133,O43293,P07951 233 1.36e-06 485 29 10 0.345 0.021 GO:0008092 MF 1 cytoskeletal protein binding 1 Q9UHB6,P60709,Q92828,Q16643,Q9NYL9,P68133,P06396,Q9Y281,Q13045,P07951 233 1.39e-06 101 29 6 0.207 0.059 GO:0043292 CC 1 contractile fiber 1 O14974,O60237,Q9NYL9,P68133,Q9Y281,P07951 233 2.82e-06 59 29 5 0.172 0.085 GO:0005884 CC 1 actin filament 1 Q14247,Q69YQ0,Q5M775,P68133,Q9Y4I1 233 3.57e-06 195 29 7 0.241 0.036 GO:0003779 MF 1 actin binding 1 Q9UHB6,Q92828,Q16643,P06396,Q9Y281,Q13045,P07951 233 6.28e-06 212 29 7 0.241 0.033 GO:0007015 BP 1 actin filament organization 1 Q9UHB6,Q14247,Q16643,Q9NYL9,P68133,P06396,Q9Y281 233 8.02e-06 746 29 11 0.379 0.015 GO:0030054 CC 1 cell junction 1 Q14126,Q9UHB6,O14974,P60709,Q14247,O60292,Q16643,Q32MZ4,Q9NYL9,P06396,Q8N556 233 8.45e-06 591 29 10 0.345 0.017 GO:0070161 CC 1 anchoring junction 1 Q14126,Q9UHB6,O14974,P60709,Q14247,Q16643,Q32MZ4,Q9NYL9,P06396,Q8N556 233 1.40e-05 1168 29 13 0.448 0.011 GO:1902589 BP 1 single-organism organelle organization 1 Q9UHB6,O14974,Q14247,Q69YQ0,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,O43166 233 1.78e-05 37 29 4 0.138 0.108 GO:0042641 CC 1 actomyosin 1 Q9UHB6,O60292,Q16643,P68133 233 5.64e-05 15 29 3 0.103 0.200 GO:0005865 CC 1 striated muscle thin filament 1 Q9NYL9,P68133,P07951 233 6.19e-05 193 29 6 0.207 0.031 GO:0032970 BP 1 regulation of actin filament-based process 1 Q14126,Q9UHB6,Q14247,P06396,Q9Y281,O43293 233 7.11e-05 582 29 9 0.310 0.015 GO:0005912 CC 1 adherens junction 1 Q9UHB6,O14974,P60709,Q14247,Q16643,Q32MZ4,Q9NYL9,P06396,Q8N556 233 8.40e-05 17 29 3 0.103 0.176 GO:0036379 CC 1 myofilament 1 Q9NYL9,P68133,P07951 233 1.05e-04 8 29 3 0.103 0.375 OMIM:161800 omi 1 Nemaline Myopathy 1 P68133,Q9Y281,P07951 233 1.63e-04 64 29 4 0.138 0.062 GO:0031532 BP 1 actin cytoskeleton reorganization 1 Q14247,P06396,O43293,O43166 233 1.89e-04 22 29 3 0.103 0.136 GO:0030834 BP 1 regulation of actin filament depolymerization 1 Q9UHB6,P06396,Q9Y281 233 2.08e-04 68 29 4 0.138 0.059 GO:0006937 BP 1 regulation of muscle contraction 1 Q14126,O60237,Q14247,O43293 233 2.89e-04 693 29 9 0.310 0.013 GO:0003008 BP 1 system process 1 Q14126,O60237,Q14247,Q9NYL9,P68133,P06396,O43293,Q4KMQ1,P07951 233 3.40e-04 77 29 4 0.138 0.052 GO:0030048 BP 1 actin filament-based movement 1 Q14126,P68133,Q9Y4I1,P07951 233 3.55e-04 27 29 3 0.103 0.111 GO:0030042 BP 1 actin filament depolymerization 1 Q9UHB6,P06396,Q9Y281 233 3.82e-04 266 29 6 0.207 0.023 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 Q14247,Q69YQ0,Q5M775,Q5TB80,P68133,Q9Y4I1 233 4.51e-04 274 29 6 0.207 0.022 GO:0099081 CC 1 supramolecular polymer 1 Q14247,Q69YQ0,Q5M775,Q5TB80,P68133,Q9Y4I1 233 4.51e-04 274 29 6 0.207 0.022 GO:0099512 CC 1 supramolecular fiber 1 Q14247,Q69YQ0,Q5M775,Q5TB80,P68133,Q9Y4I1 233 4.60e-04 275 29 6 0.207 0.022 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q14126,Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 4.79e-04 277 29 6 0.207 0.022 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q14126,Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 5.01e-04 85 29 4 0.138 0.047 GO:0090257 BP 1 regulation of muscle system process 1 Q14126,O60237,Q14247,O43293 233 5.17e-04 170 29 5 0.172 0.029 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 Q9UHB6,Q14247,P06396,Q9Y281,O43293 233 5.42e-04 31 29 3 0.103 0.097 GO:0097517 CC 1 contractile actin filament bundle 1 Q9UHB6,O60292,P68133 233 5.42e-04 31 29 3 0.103 0.097 GO:0001725 CC 1 stress fiber 1 Q9UHB6,O60292,P68133 233 5.56e-04 420 29 7 0.241 0.017 GO:0005911 CC 1 cell-cell junction 1 Q14126,Q9UHB6,Q14247,O60292,Q16643,Q32MZ4,Q9NYL9 233 6.68e-04 294 29 6 0.207 0.020 GO:0099080 CC 1 supramolecular complex 1 Q14247,Q69YQ0,Q5M775,Q5TB80,P68133,Q9Y4I1 233 7.13e-04 93 29 4 0.138 0.043 GO:0008064 BP 1 regulation of actin polymerization or depolymerization 1 Q9UHB6,Q14247,P06396,Q9Y281 233 7.18e-04 34 29 3 0.103 0.088 GO:0032432 CC 1 actin filament bundle 1 Q9UHB6,O60292,P68133 233 7.18e-04 34 29 3 0.103 0.088 GO:1901879 BP 1 regulation of protein depolymerization 1 Q9UHB6,P06396,Q9Y281 233 7.44e-04 94 29 4 0.138 0.043 GO:0030832 BP 1 regulation of actin filament length 1 Q9UHB6,Q14247,P06396,Q9Y281 233 9.71e-04 2262 29 15 0.517 0.007 GO:0006996 BP 1 organelle organization 1 Q9UHB6,O14974,Q14247,Q69YQ0,O60292,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,Q9Y4I1,O43166 233 1.13e-03 7 29 2 0.069 0.286 GO:0005522 MF 1 profilin binding 1 Q14247,Q16643 233 1.33e-03 333 29 6 0.207 0.018 GO:0005925 CC 1 focal adhesion 1 Q9UHB6,O14974,P60709,Q14247,P06396,Q8N556 233 1.33e-03 333 29 6 0.207 0.018 GO:0005924 CC 1 cell-substrate adherens junction 1 Q9UHB6,O14974,P60709,Q14247,P06396,Q8N556 233 1.42e-03 337 29 6 0.207 0.018 GO:0030055 CC 1 cell-substrate junction 1 Q9UHB6,O14974,P60709,Q14247,P06396,Q8N556 233 1.55e-03 20 29 3 0.103 0.150 REAC:5627123 rea 1 RHO GTPases activate PAKs 1 O14974,O60237,Q14247 233 1.67e-03 45 29 3 0.103 0.067 GO:0043244 BP 1 regulation of protein complex disassembly 1 Q9UHB6,P06396,Q9Y281 233 1.67e-03 45 29 3 0.103 0.067 GO:0030018 CC 1 Z disc 1 O14974,O60237,Q9Y281 233 1.69e-03 661 29 8 0.276 0.012 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 P60709,O60237,O60292,P68133,Q9Y281,O43293,Q4KMQ1,P07951 233 1.74e-03 117 29 4 0.138 0.034 GO:0008154 BP 1 actin polymerization or depolymerization 1 Q9UHB6,Q14247,P06396,Q9Y281 233 2.29e-03 50 29 3 0.103 0.060 GO:0030426 CC 1 growth cone 1 Q14247,Q16643,Q9Y4I1 233 2.32e-03 369 29 6 0.207 0.016 GO:0050839 MF 1 cell adhesion molecule binding 1 Q14126,Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 2.72e-03 53 29 3 0.103 0.057 GO:0031674 CC 1 I band 1 O14974,O60237,Q9Y281 233 2.72e-03 53 29 3 0.103 0.057 GO:0030427 CC 1 site of polarized growth 1 Q14247,Q16643,Q9Y4I1 233 2.88e-03 54 29 3 0.103 0.056 GO:0051261 BP 1 protein depolymerization 1 Q9UHB6,P06396,Q9Y281 233 2.93e-03 11 29 2 0.069 0.182 GO:0030275 MF 1 LRR domain binding 1 Q9Y608,O43293 233 2.93e-03 11 29 2 0.069 0.182 GO:0031672 CC 1 A band 1 O14974,O60237 233 4.12e-03 265 29 5 0.172 0.019 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q9UHB6,Q14247,P06396,Q9Y281,O43293 233 4.13e-03 61 29 3 0.103 0.049 GO:0070252 BP 1 actin-mediated cell contraction 1 Q14126,P68133,P07951 233 4.56e-03 271 29 5 0.172 0.018 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 5.20e-03 156 29 4 0.138 0.026 GO:0034330 BP 1 cell junction organization 1 Q14126,P60709,Q14247,O43293 233 5.47e-03 282 29 5 0.172 0.018 GO:0045296 MF 1 cadherin binding 1 Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 6.34e-03 16 29 2 0.069 0.125 GO:0030835 BP 1 negative regulation of actin filament depolymerization 1 Q9UHB6,P06396 233 6.34e-03 16 29 2 0.069 0.125 GO:0006940 BP 1 regulation of smooth muscle contraction 1 Q14247,O43293 233 6.61e-03 294 29 5 0.172 0.017 GO:0005913 CC 1 cell-cell adherens junction 1 Q9UHB6,Q14247,Q16643,Q32MZ4,Q9NYL9 233 7.49e-03 2024 29 13 0.448 0.006 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 7.56e-03 75 29 3 0.103 0.040 GO:0098858 CC 1 actin-based cell projection 1 P68133,Q4KMQ1,Q9Y4I1 233 8.17e-03 176 29 4 0.138 0.023 GO:0032535 BP 1 regulation of cellular component size 1 Q9UHB6,Q14247,P06396,Q9Y281 233 9.40e-03 2072 29 13 0.448 0.006 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045 233 1.01e-02 83 29 3 0.103 0.036 GO:0072562 CC 1 blood microparticle 1 P60709,P68133,P06396 233 1.04e-02 678 29 7 0.241 0.010 GO:0007155 BP 1 cell adhesion 1 Q14126,O14974,P60709,Q14247,Q69YQ0,P06396,O43293 233 1.08e-02 1091 29 9 0.310 0.008 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q14126,P60709,O60237,Q14247,Q5M775,P68133,Q9Y281,Q86V48,Q13045 233 1.10e-02 684 29 7 0.241 0.010 GO:0022610 BP 1 biological adhesion 1 Q14126,O14974,P60709,Q14247,Q69YQ0,P06396,O43293 233 1.10e-02 21 29 2 0.069 0.095 GO:0031941 CC 1 filamentous actin 1 Q69YQ0,Q5M775 233 1.28e-02 90 29 3 0.103 0.033 GO:0051015 MF 1 actin filament binding 1 Q9UHB6,Q92828,Q9Y281 233 1.33e-02 3045 29 16 0.552 0.005 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 1.37e-02 1129 29 9 0.310 0.008 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q5M775,Q86V48,Q13045,Q8N556 233 1.37e-02 1880 29 12 0.414 0.006 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q14126,Q9UHB6,P60709,Q14247,Q16643,Q5M775,Q5TB80,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 1.57e-02 728 29 7 0.241 0.010 GO:0042995 CC 1 cell projection 1 Q14247,Q16643,Q5TB80,P68133,Q4KMQ1,Q9Y4I1,O43166 233 1.62e-02 1396 29 10 0.345 0.007 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9UHB6,P60709,Q14247,Q16643,Q5M775,Q5TB80,P06396,Q86V48,Q13045,Q8N556 233 1.68e-02 214 29 4 0.138 0.019 GO:0044057 BP 1 regulation of system process 1 Q14126,O60237,Q14247,O43293 233 1.69e-02 1 29 1 0.034 1.000 OMIM:609285 omi 1 NEMALINE MYOPATHY 4; NEM4CAP MYOPATHY 2, INCLUDED; CAPM2, INCLUDED 1 P07951 233 1.69e-02 1 29 1 0.034 1.000 OMIM:214450 omi 1 GRISCELLI SYNDROME, TYPE 1; GS1;;GRISCELLI SYNDROME WITH NEUROLOGIC IMPAIRMENT;;PARTIAL ALBINISM AND PRIMARY NEUROLOGIC DISEASE WITHOUT HEMOPHAGOCYTICSYNDROME;;GRISCELLI SYNDROME, CUTANEOUS AND NEUROLOGIC TYPE 1 Q9Y4I1 233 1.69e-02 1 29 1 0.034 1.000 OMIM:607371 omi 1 DYSTONIA, JUVENILE-ONSET; DJO 1 P60709 233 1.69e-02 1 29 1 0.034 1.000 OMIM:613307 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 79; DFNB79 1 Q4KMQ1 233 1.69e-02 1 29 1 0.034 1.000 OMIM:612877 omi 1 CARDIOMYOPATHY, DILATED, 1BB; CMD1BB 1 Q14126 233 1.69e-02 1 29 1 0.034 1.000 OMIM:600251 omi 1 FACIAL CLEFTING, OBLIQUE, 1; OBLFC1;;OCULOMAXILLOFACIAL DYSPLASIA WITH OBLIQUE FACIAL CLEFTS 1 Q69YQ0 233 1.69e-02 1 29 1 0.034 1.000 OMIM:145410 omi 1 OPITZ GBBB SYNDROME, TYPE II; GBBB2;;OPITZ GBBB SYNDROME, AUTOSOMAL DOMINANT;;HYPERTELORISM WITH ESOPHAGEAL ABNORMALITY AND HYPOSPADIAS;;G SYNDROME;;HYPOSPADIAS-DYSPHAGIA SYNDROME;;OPITZ-FRIAS SYNDROME;;OPITZ-G SYNDROME, TYPE II; OGS2;;TELECANTHUS WITH ASSOCIATED ABNORMALITIES;;BBB SYNDROME;;HYPERTELORISM-HYPOSPADIAS SYNDROME;;TELECANTHUS-HYPOSPADIAS SYNDROME;;OPITZ BBBG SYNDROME;;GBBB SYNDROME;;OPITZ OCULOGENITOLARYNGEAL SYNDROME, TYPE II;;CHROMOSOME 22q11.2 DELETION SYNDROME, OPITZ PHENOTYPE 1 Q69YQ0 233 1.69e-02 1 29 1 0.034 1.000 OMIM:243310 omi 1 Baraitser-Winter Syndrome 1 P60709 233 1.69e-02 1 29 1 0.034 1.000 OMIM:105120 omi 1 AMYLOIDOSIS, FINNISH TYPE;;AMYLOIDOSIS V;;AMYLOIDOSIS, MERETOJA TYPE;;AMYLOID CRANIAL NEUROPATHY WITH LATTICE CORNEAL DYSTROPHY;;AMYLOIDOSIS DUE TO MUTANT GELSOLINCEREBRAL AMYLOID ANGIOPATHY, GSN-RELATED, INCLUDED;;CORNEAL DYSTROPHY, LATTICE TYPE II, INCLUDED; LCD2, INCLUDED;;LATTICE CORNEAL DYSTROPHY, TYPE II, INCLUDED 1 P06396 233 1.69e-02 1 29 1 0.034 1.000 OMIM:610687 omi 1 NEMALINE MYOPATHY 7; NEM7 1 Q9Y281 233 1.69e-02 1 29 1 0.034 1.000 OMIM:610193 omi 1 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 10; ARVD10;;ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY 10; ARVC10 1 Q14126 233 1.71e-02 215 29 4 0.138 0.019 GO:0090066 BP 1 regulation of anatomical structure size 1 Q9UHB6,Q14247,P06396,Q9Y281 233 1.75e-02 1933 29 12 0.414 0.006 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q14126,P60709,O60237,Q14247,Q5M775,Q5TB80,P68133,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 1.82e-02 27 29 2 0.069 0.074 GO:0030239 BP 1 myofibril assembly 1 Q9NYL9,P68133 233 1.82e-02 27 29 2 0.069 0.074 GO:1901880 BP 1 negative regulation of protein depolymerization 1 Q9UHB6,P06396 233 2.06e-02 753 29 7 0.241 0.009 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q14126,Q9UHB6,P60709,Q14247,Q5M775,Q86V48,Q13045 233 2.10e-02 29 29 2 0.069 0.069 GO:0043242 BP 1 negative regulation of protein complex disassembly 1 Q9UHB6,P06396 233 2.16e-02 233 29 4 0.138 0.017 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 P60709,O60237,P68133,Q9Y281 233 2.22e-02 1 29 1 0.034 1.000 GO:0003164 BP 1 His-Purkinje system development 1 Q14126 233 2.22e-02 1 29 1 0.034 1.000 GO:0061689 CC 1 tricellular tight junction 1 O60292 233 2.22e-02 1 29 1 0.034 1.000 GO:0044858 BP 1 plasma membrane raft polarization 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0030478 CC 1 actin cap 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0044856 BP 1 plasma membrane raft localization 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0001766 BP 1 membrane raft polarization 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0003165 BP 1 Purkinje myocyte development 1 Q14126 233 2.22e-02 1 29 1 0.034 1.000 GO:0044855 BP 1 plasma membrane raft distribution 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0035508 BP 1 positive regulation of myosin-light-chain-phosphatase activity 1 O14974 233 2.22e-02 1 29 1 0.034 1.000 GO:1903906 BP 1 regulation of plasma membrane raft polarization 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0031580 BP 1 membrane raft distribution 1 P06396 233 2.22e-02 1 29 1 0.034 1.000 GO:0097284 BP 1 hepatocyte apoptotic process 1 P06396 233 2.28e-02 110 29 3 0.103 0.027 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 Q14247,P06396,Q9Y281 233 2.38e-02 2286 29 13 0.448 0.006 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 2.40e-02 3208 29 16 0.552 0.005 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 2.40e-02 31 29 2 0.069 0.065 GO:0030049 BP 1 muscle filament sliding 1 P68133,P07951 233 2.40e-02 31 29 2 0.069 0.065 GO:0033275 BP 1 actin-myosin filament sliding 1 P68133,P07951 233 2.50e-02 1016 29 8 0.276 0.008 GO:0006928 BP 1 movement of cell or subcellular component 1 Q14126,P60709,Q14247,P68133,P06396,O43293,Q9Y4I1,P07951 233 2.51e-02 790 29 7 0.241 0.009 GO:0048468 BP 1 cell development 1 O14974,Q14247,O60292,Q16643,Q9NYL9,P68133,O43166 233 2.56e-02 32 29 2 0.069 0.062 GO:0006939 BP 1 smooth muscle contraction 1 Q14247,O43293 233 2.74e-02 3247 29 16 0.552 0.005 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 2.81e-02 6256 29 24 0.828 0.004 HPA:026020 hpa 1 ovary; ovarian stroma cells 1 Q14126,Q9UHB6,Q9UPQ0,P60709,O60237,Q14247,Q9Y608,O60292,Q92828,Q16643,Q5M775,Q5TB80,Q9NYL9,P68133,Q6NYC8,P06396,Q9Y281,O43293,Q86V48,Q4KMQ1,Q13045,Q8N556,O43166,P07951 233 2.81e-02 2328 29 13 0.448 0.006 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 2.84e-02 409 29 5 0.172 0.012 GO:0044463 CC 1 cell projection part 1 Q14247,Q16643,Q5TB80,Q9Y4I1,O43166 233 2.97e-02 413 29 5 0.172 0.012 GO:0097458 CC 1 neuron part 1 Q14247,Q16643,Q4KMQ1,Q9Y4I1,O43166 233 3.07e-02 3073 29 15 0.517 0.005 GO:0032501 BP 1 multicellular organismal process 1 Q14126,O14974,P60709,O60237,Q14247,O60292,Q16643,Q32MZ4,Q9NYL9,P68133,P06396,O43293,Q4KMQ1,O43166,P07951 233 3.41e-02 37 29 2 0.069 0.054 GO:0017022 MF 1 myosin binding 1 P68133,P06396 233 3.42e-02 127 29 3 0.103 0.024 GO:0034329 BP 1 cell junction assembly 1 P60709,Q14247,O43293 233 3.57e-02 3326 29 16 0.552 0.005 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 3.66e-02 3334 29 16 0.552 0.005 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 3.73e-02 7283 29 26 0.897 0.004 HPA:022020 hpa 1 lung; pneumocytes 1 Q14126,Q9UHB6,Q9UPQ0,P60709,O60237,Q14247,Q9Y608,O60292,Q92828,Q16643,Q32MZ4,Q5M775,Q5TB80,Q9NYL9,P68133,Q6NYC8,P06396,Q9Y281,O43293,Q86V48,Q4KMQ1,Q13045,Q8N556,O43166,P07951,Q6P4F7 233 3.78e-02 3344 29 16 0.552 0.005 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 3.78e-02 3344 29 16 0.552 0.005 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 3.81e-02 132 29 3 0.103 0.023 GO:0045216 BP 1 cell-cell junction organization 1 Q14126,Q14247,O43293 233 3.89e-02 4759 29 21 0.724 0.004 TF:M03807_1 tf 1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 1 Q9UHB6,Q9UPQ0,P60709,Q14247,Q9Y608,Q69YQ0,Q92828,Q16643,Q32MZ4,P68133,Q6NYC8,P06396,Q9Y281,O43293,Q86V48,Q4KMQ1,Q13045,Q8N556,Q9Y4I1,P07951,Q6P4F7 233 3.92e-02 3355 29 16 0.552 0.005 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.00e-02 3361 29 16 0.552 0.005 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.11e-02 3370 29 16 0.552 0.005 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.23e-02 3379 29 16 0.552 0.005 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.33e-02 3386 29 16 0.552 0.005 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.33e-02 3386 29 16 0.552 0.005 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.33e-02 3386 29 16 0.552 0.005 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.37e-02 42 29 2 0.069 0.048 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 Q9NYL9,P68133 233 4.38e-02 3390 29 16 0.552 0.005 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.40e-02 2153 29 12 0.414 0.006 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q86V48,Q13045,Q8N556 233 4.42e-02 456 29 5 0.172 0.011 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 Q92828,Q5TB80,Q9Y281,Q86V48,Q8N556 233 4.43e-02 3882 29 17 0.586 0.004 GO:0016043 BP 1 cellular component organization 1 Q14126,Q9UHB6,O14974,P60709,Q14247,Q69YQ0,O60292,Q92828,Q16643,Q5M775,Q9NYL9,P68133,P06396,Q9Y281,O43293,Q9Y4I1,O43166 233 4.44e-02 2 29 1 0.034 0.500 GO:0030240 BP 1 skeletal muscle thin filament assembly 1 P68133 233 4.44e-02 2 29 1 0.034 0.500 GO:0097433 CC 1 dense body 1 P60709 233 4.44e-02 2 29 1 0.034 0.500 GO:1903903 BP 1 regulation of establishment of T cell polarity 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:0001768 BP 1 establishment of T cell polarity 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:0051665 BP 1 membrane raft localization 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:1903923 BP 1 positive regulation of protein processing in phagocytic vesicle 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:1903921 BP 1 regulation of protein processing in phagocytic vesicle 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:1903909 BP 1 regulation of receptor clustering 1 P06396 233 4.44e-02 2 29 1 0.034 0.500 GO:1900756 BP 1 protein processing in phagocytic vesicle 1 P06396 233 4.50e-02 2159 29 12 0.414 0.006 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q86V48,Q13045,Q8N556 233 4.52e-02 2454 29 13 0.448 0.005 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.57e-02 3403 29 16 0.552 0.005 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.57e-02 43 29 2 0.069 0.047 GO:0048167 BP 1 regulation of synaptic plasticity 1 Q16643,O43166 233 4.58e-02 2458 29 13 0.448 0.005 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 Q14126,Q9UHB6,P60709,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.60e-02 3405 29 16 0.552 0.005 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.62e-02 3407 29 16 0.552 0.005 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.62e-02 3407 29 16 0.552 0.005 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.64e-02 6886 29 25 0.862 0.004 HPA:002020 hpa 1 appendix; lymphoid tissue 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q9Y608,O60292,Q92828,Q16643,Q32MZ4,Q5M775,Q5TB80,Q9NYL9,P68133,Q6NYC8,P06396,Q9Y281,O43293,Q86V48,Q4KMQ1,Q13045,Q8N556,Q9Y4I1,O43166,P07951 233 4.68e-02 1885 29 11 0.379 0.006 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q9UHB6,Q14247,Q92828,Q16643,Q5M775,Q5TB80,Q6NYC8,Q9Y281,Q86V48,Q13045,Q8N556 233 4.71e-02 3413 29 16 0.552 0.005 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.74e-02 3415 29 16 0.552 0.005 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.76e-02 3416 29 16 0.552 0.005 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.76e-02 3416 29 16 0.552 0.005 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.76e-02 3416 29 16 0.552 0.005 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.77e-02 286 29 4 0.138 0.014 GO:0043005 CC 1 neuron projection 1 Q14247,Q16643,Q9Y4I1,O43166 233 4.79e-02 3418 29 16 0.552 0.005 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.82e-02 3420 29 16 0.552 0.005 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.83e-02 3421 29 16 0.552 0.005 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.85e-02 3422 29 16 0.552 0.005 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.85e-02 3422 29 16 0.552 0.005 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.86e-02 3423 29 16 0.552 0.005 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.86e-02 3423 29 16 0.552 0.005 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.88e-02 3424 29 16 0.552 0.005 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.91e-02 3426 29 16 0.552 0.005 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.91e-02 3426 29 16 0.552 0.005 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.94e-02 3428 29 16 0.552 0.005 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.95e-02 3429 29 16 0.552 0.005 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.95e-02 3429 29 16 0.552 0.005 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.95e-02 3429 29 16 0.552 0.005 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.97e-02 3430 29 16 0.552 0.005 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 4.98e-02 3431 29 16 0.552 0.005 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 45 29 2 0.069 0.044 GO:0030175 CC 1 filopodium 1 P68133,Q9Y4I1 233 5.00e-02 3432 29 16 0.552 0.005 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 2 29 1 0.034 0.500 CORUM:2254 cor 1 CTGF/Hcs24-actin complex 1 P60709 233 5.00e-02 2 29 1 0.034 0.500 CORUM:1130 cor 1 Hip1R-cortactin complex 1 Q14247 233 5.00e-02 3 29 1 0.034 0.333 OMIM:601680 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 2B; DA2B;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE 2B;;SHELDON-HALL SYNDROME; SHS;;FREEMAN-SHELDON SYNDROME VARIANT; FSSV;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE II, WITH CRANIOFACIALABNORMALITIES 1 P07951 233 5.00e-02 9 29 3 0.103 0.333 HP:0003798 hp 1 Nemaline bodies 1 P68133,Q9Y281,P07951 233 5.00e-02 441 29 6 0.207 0.014 MI:hsa-miR-647 mi 1 MI:hsa-miR-647 1 P60709,O60237,Q14247,Q5M775,P68133,O43166 233 5.00e-02 17 29 2 0.069 0.118 REAC:5627117 rea 1 RHO GTPases Activate ROCKs 1 O14974,O60237 233 5.00e-02 3432 29 16 0.552 0.005 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 6221 29 24 0.828 0.004 TF:M01873_0 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 0 1 Q14126,Q9UHB6,O14974,Q9UPQ0,P60709,Q14247,Q9Y608,Q69YQ0,O60292,Q92828,Q16643,Q32MZ4,Q5M775,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q4KMQ1,Q13045,Q8N556,Q9Y4I1,P07951,Q6P4F7 233 5.00e-02 3432 29 16 0.552 0.005 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 3432 29 16 0.552 0.005 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 45 29 2 0.069 0.044 GO:0055002 BP 1 striated muscle cell development 1 Q9NYL9,P68133 233 5.00e-02 3 29 1 0.034 0.333 OMIM:255310 omi 1 MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION; CFTD;;FIBER-TYPE DISPROPORTION MYOPATHY, CONGENITAL; CFTDM 1 P68133 233 5.00e-02 2 29 1 0.034 0.500 CORUM:756 cor 1 Prune-Gelsolin complex 1 P06396 233 5.00e-02 175 29 5 0.172 0.029 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 O14974,P60709,O60237,P06396,Q9Y281 233 5.00e-02 3432 29 16 0.552 0.005 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 2 29 1 0.034 0.500 CORUM:817 cor 1 MRIP-MBS complex 1 O14974 233 5.00e-02 3432 29 16 0.552 0.005 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 233 5.00e-02 3432 29 16 0.552 0.005 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 Q14126,Q9UHB6,P60709,O60237,Q14247,Q92828,Q16643,Q5M775,Q5TB80,P68133,Q6NYC8,P06396,Q9Y281,Q86V48,Q13045,Q8N556 234 1.67e-02 1 2 1 0.500 1.000 OMIM:614640 omi 1 UV-SENSITIVE SYNDROME 3; UVSS3 1 Q2YD98 234 2.39e-02 52 2 1 0.500 0.019 REAC:6781823 rea 1 Formation of TC-NER Pre-Incision Complex 1 Q2YD98 234 2.90e-02 63 2 1 0.500 0.016 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 Q2YD98 234 2.94e-02 64 2 1 0.500 0.016 REAC:6782135 rea 1 Dual incision in TC-NER 1 Q2YD98 234 3.54e-02 77 2 1 0.500 0.013 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 Q2YD98 234 5.00e-02 109 2 1 0.500 0.009 REAC:5696398 rea 1 Nucleotide Excision Repair 1 Q2YD98 234 5.00e-02 3 2 1 0.500 0.333 HP:0007623 hp 1 Pigmentation anomalies of sun-exposed skin 1 Q2YD98 234 5.00e-02 468 2 2 1.000 0.004 MI:hsa-miR-220 mi 1 MI:hsa-miR-220 1 Q2YD98,P06454 234 5.00e-02 21 2 1 0.500 0.048 GO:0000993 MF 1 RNA polymerase II core binding 1 Q2YD98 234 5.00e-02 3 2 1 0.500 0.333 OMIM:600630 omi 1 UV-Sensitive Syndrome 1 Q2YD98 234 5.00e-02 82 2 2 1.000 0.024 TF:M04109_0 tf 1 Factor: RUNX3; motif: NRACCGCAAACCGCAN; match class: 0 1 Q2YD98,P06454 235 4.50e-06 127 3 3 1.000 0.024 GO:0005788 CC 1 endoplasmic reticulum lumen 1 P14625,P27797,P07237 235 5.60e-06 9 3 2 0.667 0.222 GO:0036500 BP 1 ATF6-mediated unfolded protein response 1 P14625,P27797 235 1.21e-05 13 3 2 0.667 0.154 GO:0034975 BP 1 protein folding in endoplasmic reticulum 1 P14625,P27797 235 1.21e-05 13 3 2 0.667 0.154 GO:0071682 CC 1 endocytic vesicle lumen 1 P14625,P27797 235 2.02e-05 209 3 3 1.000 0.014 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 P14625,P27797,P07237 235 3.67e-05 15 3 2 0.667 0.133 REAC:3000480 rea 1 Scavenging by Class A Receptors 1 P14625,P27797 235 5.02e-05 152 3 3 1.000 0.020 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 P14625,P27797,P07237 235 6.31e-05 29 3 2 0.667 0.069 GO:0006984 BP 1 ER-nucleus signaling pathway 1 P14625,P27797 235 8.23e-05 333 3 3 1.000 0.009 GO:0005925 CC 1 focal adhesion 1 P14625,P27797,P07237 235 8.23e-05 333 3 3 1.000 0.009 GO:0005924 CC 1 cell-substrate adherens junction 1 P14625,P27797,P07237 235 8.53e-05 337 3 3 1.000 0.009 GO:0030055 CC 1 cell-substrate junction 1 P14625,P27797,P07237 235 1.52e-04 30 3 2 0.667 0.067 REAC:2173782 rea 1 Binding and Uptake of Ligands by Scavenger Receptors 1 P14625,P27797 235 2.14e-04 53 3 2 0.667 0.038 GO:0051208 BP 1 sequestering of calcium ion 1 P14625,P27797 235 2.22e-04 54 3 2 0.667 0.037 GO:0005178 MF 1 integrin binding 1 P27797,P07237 235 3.43e-04 67 3 2 0.667 0.030 GO:0051238 BP 1 sequestering of metal ion 1 P14625,P27797 235 3.53e-04 68 3 2 0.667 0.029 GO:0060205 CC 1 cytoplasmic vesicle lumen 1 P14625,P27797 235 3.64e-04 69 3 2 0.667 0.029 GO:0031983 CC 1 vesicle lumen 1 P14625,P27797 235 4.41e-04 582 3 3 1.000 0.005 GO:0005912 CC 1 adherens junction 1 P14625,P27797,P07237 235 4.62e-04 591 3 3 1.000 0.005 GO:0070161 CC 1 anchoring junction 1 P14625,P27797,P07237 235 6.38e-04 658 3 3 1.000 0.005 GO:0044432 CC 1 endoplasmic reticulum part 1 P14625,P27797,P07237 235 7.06e-04 96 3 2 0.667 0.021 GO:0030968 BP 1 endoplasmic reticulum unfolded protein response 1 P14625,P27797 235 7.50e-04 99 3 2 0.667 0.020 GO:0034620 BP 1 cellular response to unfolded protein 1 P14625,P27797 235 8.75e-04 731 3 3 1.000 0.004 GO:0005102 MF 1 receptor binding 1 P14625,P27797,P07237 235 8.97e-04 1 3 1 0.333 1.000 GO:0016222 CC 1 procollagen-proline 4-dioxygenase complex 1 P07237 235 8.97e-04 1 3 1 0.333 1.000 GO:0002502 BP 1 peptide antigen assembly with MHC class I protein complex 1 P27797 235 8.97e-04 1 3 1 0.333 1.000 GO:0002397 BP 1 MHC class I protein complex assembly 1 P27797 235 9.30e-04 746 3 3 1.000 0.004 GO:0042981 BP 1 regulation of apoptotic process 1 P14625,P27797,P07237 235 9.30e-04 746 3 3 1.000 0.004 GO:0030054 CC 1 cell junction 1 P14625,P27797,P07237 235 9.68e-04 756 3 3 1.000 0.004 GO:0043067 BP 1 regulation of programmed cell death 1 P14625,P27797,P07237 235 9.78e-04 113 3 2 0.667 0.018 GO:0035967 BP 1 cellular response to topologically incorrect protein 1 P14625,P27797 235 1.01e-03 115 3 2 0.667 0.017 GO:0001666 BP 1 response to hypoxia 1 P14625,P07237 235 1.04e-03 78 3 2 0.667 0.026 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 P14625,P27797 235 1.07e-03 118 3 2 0.667 0.017 GO:0036293 BP 1 response to decreased oxygen levels 1 P14625,P07237 235 1.12e-03 121 3 2 0.667 0.017 GO:0006986 BP 1 response to unfolded protein 1 P14625,P27797 235 1.14e-03 122 3 2 0.667 0.016 GO:0070482 BP 1 response to oxygen levels 1 P14625,P07237 235 1.19e-03 811 3 3 1.000 0.004 GO:0010941 BP 1 regulation of cell death 1 P14625,P27797,P07237 235 1.44e-03 137 3 2 0.667 0.015 GO:0035966 BP 1 response to topologically incorrect protein 1 P14625,P27797 235 1.63e-03 146 3 2 0.667 0.014 GO:0006898 BP 1 receptor-mediated endocytosis 1 P14625,P27797 235 1.77e-03 152 3 2 0.667 0.013 GO:0006457 BP 1 protein folding 1 P14625,P27797 235 1.79e-03 2 3 1 0.333 0.500 GO:0031247 BP 1 actin rod assembly 1 P14625 235 1.82e-03 933 3 3 1.000 0.003 GO:0005783 CC 1 endoplasmic reticulum 1 P14625,P27797,P07237 235 1.84e-03 936 3 3 1.000 0.003 GO:0006915 BP 1 apoptotic process 1 P14625,P27797,P07237 235 1.96e-03 956 3 3 1.000 0.003 GO:0012501 BP 1 programmed cell death 1 P14625,P27797,P07237 235 2.02e-03 1179 3 3 1.000 0.003 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 P14625,P27797,P07237 235 2.06e-03 164 3 2 0.667 0.012 GO:0006874 BP 1 cellular calcium ion homeostasis 1 P14625,P27797 235 2.24e-03 171 3 2 0.667 0.012 GO:0055074 BP 1 calcium ion homeostasis 1 P14625,P27797 235 2.44e-03 1029 3 3 1.000 0.003 GO:0008219 BP 1 cell death 1 P14625,P27797,P07237 235 2.45e-03 179 3 2 0.667 0.011 GO:0072503 BP 1 cellular divalent inorganic cation homeostasis 1 P14625,P27797 235 2.51e-03 181 3 2 0.667 0.011 GO:0030139 CC 1 endocytic vesicle 1 P14625,P27797 235 2.53e-03 2 3 1 0.333 0.500 REAC:168268 rea 1 Virus Assembly and Release 1 P27797 235 2.53e-03 2 3 1 0.333 0.500 REAC:168316 rea 1 Assembly of Viral Components at the Budding Site 1 P27797 235 2.54e-03 182 3 2 0.667 0.011 GO:0051235 BP 1 maintenance of location 1 P14625,P27797 235 2.65e-03 186 3 2 0.667 0.011 GO:0005509 MF 1 calcium ion binding 1 P14625,P27797 235 2.69e-03 3 3 1 0.333 0.333 GO:0042824 CC 1 MHC class I peptide loading complex 1 P27797 235 2.69e-03 3 3 1 0.333 0.333 GO:0018401 BP 1 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 1 P07237 235 2.69e-03 3 3 1 0.333 0.333 GO:0004656 MF 1 procollagen-proline 4-dioxygenase activity 1 P07237 235 2.69e-03 3 3 1 0.333 0.333 GO:0002501 BP 1 peptide antigen assembly with MHC protein complex 1 P27797 235 2.76e-03 190 3 2 0.667 0.011 GO:0072507 BP 1 divalent inorganic cation homeostasis 1 P14625,P27797 235 3.41e-03 1403 3 3 1.000 0.002 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 P14625,P27797,P07237 235 3.53e-03 215 3 2 0.667 0.009 GO:0098552 CC 1 side of membrane 1 P27797,P07237 235 3.59e-03 4 3 1 0.333 0.250 GO:2000510 BP 1 positive regulation of dendritic cell chemotaxis 1 P27797 235 3.59e-03 4 3 1 0.333 0.250 GO:0001849 MF 1 complement component C1q binding 1 P27797 235 3.59e-03 4 3 1 0.333 0.250 GO:2000508 BP 1 regulation of dendritic cell chemotaxis 1 P27797 235 3.59e-03 4 3 1 0.333 0.250 GO:0002396 BP 1 MHC protein complex assembly 1 P27797 235 3.99e-03 1212 3 3 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 P14625,P27797,P07237 235 4.03e-03 2 3 1 0.333 0.500 HP:0005472 hp 1 Orbital craniosynostosis 1 P07237 235 4.11e-03 232 3 2 0.667 0.009 GO:0006875 BP 1 cellular metal ion homeostasis 1 P14625,P27797 235 4.48e-03 5 3 1 0.333 0.200 GO:0046598 BP 1 positive regulation of viral entry into host cell 1 P07237 235 4.48e-03 5 3 1 0.333 0.200 GO:0019511 BP 1 peptidyl-proline hydroxylation 1 P07237 235 4.48e-03 5 3 1 0.333 0.200 GO:0048387 BP 1 negative regulation of retinoic acid receptor signaling pathway 1 P27797 235 4.58e-03 245 3 2 0.667 0.008 GO:0071407 BP 1 cellular response to organic cyclic compound 1 P14625,P27797 235 4.84e-03 1576 3 3 1.000 0.002 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P14625,P27797,P07237 235 5.00e-03 256 3 2 0.667 0.008 GO:0055065 BP 1 metal ion homeostasis 1 P14625,P27797 235 5.02e-03 1 3 1 0.333 1.000 CORUM:474 cor 1 Prolyl 4-hydroxylase (alpha(III)-type) 1 P07237 235 5.02e-03 1 3 1 0.333 1.000 CORUM:5217 cor 1 Calreticulin oligomer complex 1 P27797 235 5.04e-03 257 3 2 0.667 0.008 GO:0031012 CC 1 extracellular matrix 1 P14625,P07237 235 5.06e-03 1600 3 3 1.000 0.002 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P14625,P27797,P07237 235 5.27e-03 1622 3 3 1.000 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P14625,P27797,P07237 235 5.35e-03 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 P14625,P27797,P07237 235 5.38e-03 6 3 1 0.333 0.167 GO:0031545 MF 1 peptidyl-proline 4-dioxygenase activity 1 P07237 235 5.38e-03 6 3 1 0.333 0.167 GO:0019798 MF 1 procollagen-proline dioxygenase activity 1 P07237 235 5.38e-03 6 3 1 0.333 0.167 GO:0001846 MF 1 opsonin binding 1 P27797 235 5.38e-03 6 3 1 0.333 0.167 GO:0022417 BP 1 protein maturation by protein folding 1 P27797 235 5.73e-03 274 3 2 0.667 0.007 GO:0048471 CC 1 perinuclear region of cytoplasm 1 P14625,P27797 235 6.15e-03 1707 3 3 1.000 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P14625,P27797,P07237 235 6.19e-03 285 3 2 0.667 0.007 GO:0030003 BP 1 cellular cation homeostasis 1 P14625,P27797 235 6.28e-03 7 3 1 0.333 0.143 GO:0046790 MF 1 virion binding 1 P14625 235 6.28e-03 7 3 1 0.333 0.143 GO:0071318 BP 1 cellular response to ATP 1 P14625 235 6.28e-03 7 3 1 0.333 0.143 GO:0019471 BP 1 4-hydroxyproline metabolic process 1 P07237 235 6.45e-03 291 3 2 0.667 0.007 GO:0006873 BP 1 cellular ion homeostasis 1 P14625,P27797 235 6.46e-03 1423 3 3 1.000 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 P14625,P27797,P07237 235 6.84e-03 1769 3 3 1.000 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 7.05e-03 1787 3 3 1.000 0.002 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P14625,P27797,P07237 235 7.17e-03 8 3 1 0.333 0.125 GO:0018126 BP 1 protein hydroxylation 1 P07237 235 7.23e-03 1802 3 3 1.000 0.002 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 P14625,P27797,P07237 235 7.27e-03 309 3 2 0.667 0.006 GO:0014070 BP 1 response to organic cyclic compound 1 P14625,P27797 235 7.36e-03 311 3 2 0.667 0.006 GO:0009986 CC 1 cell surface 1 P27797,P07237 235 7.36e-03 311 3 2 0.667 0.006 GO:0055080 BP 1 cation homeostasis 1 P14625,P27797 235 7.51e-03 1825 3 3 1.000 0.002 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P14625,P27797,P07237 235 7.58e-03 6 3 1 0.333 0.167 REAC:3000484 rea 1 Scavenging by Class F Receptors 1 P27797 235 7.75e-03 319 3 2 0.667 0.006 GO:0098771 BP 1 inorganic ion homeostasis 1 P14625,P27797 235 8.07e-03 9 3 1 0.333 0.111 GO:0001848 MF 1 complement binding 1 P27797 235 8.07e-03 9 3 1 0.333 0.111 GO:0048385 BP 1 regulation of retinoic acid receptor signaling pathway 1 P27797 235 8.53e-03 1904 3 3 1.000 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P14625,P27797,P07237 235 8.69e-03 338 3 2 0.667 0.006 GO:0055082 BP 1 cellular chemical homeostasis 1 P14625,P27797 235 8.80e-03 1924 3 3 1.000 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 8.96e-03 10 3 1 0.333 0.100 GO:0044183 MF 1 protein binding involved in protein folding 1 P27797 235 8.96e-03 10 3 1 0.333 0.100 GO:0033198 BP 1 response to ATP 1 P14625 235 8.96e-03 10 3 1 0.333 0.100 GO:0031543 MF 1 peptidyl-proline dioxygenase activity 1 P07237 235 9.15e-03 347 3 2 0.667 0.006 GO:0050801 BP 1 ion homeostasis 1 P14625,P27797 235 9.17e-03 1950 3 3 1.000 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 9.51e-03 1974 3 3 1.000 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 9.52e-03 354 3 2 0.667 0.006 GO:0006897 BP 1 endocytosis 1 P14625,P27797 235 9.73e-03 1989 3 3 1.000 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P14625,P27797,P07237 235 9.74e-03 1990 3 3 1.000 0.002 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 9.86e-03 1998 3 3 1.000 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P14625,P27797,P07237 235 9.86e-03 11 3 1 0.333 0.091 GO:0002407 BP 1 dendritic cell chemotaxis 1 P27797 235 9.86e-03 11 3 1 0.333 0.091 GO:0018208 BP 1 peptidyl-proline modification 1 P07237 235 1.00e-02 2 3 1 0.333 0.500 CORUM:472 cor 1 Prolyl 4-hydroxylase (alpha(I)-type) 1 P07237 235 1.01e-02 5 3 1 0.333 0.200 HP:0011974 hp 1 Myelofibrosis 1 P27797 235 1.01e-02 8 3 1 0.333 0.125 REAC:1679131 rea 1 Trafficking and processing of endosomal TLR 1 P14625 235 1.03e-02 369 3 2 0.667 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 P27797,P07237 235 1.06e-02 2049 3 3 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.07e-02 2055 3 3 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.08e-02 12 3 1 0.333 0.083 GO:0042921 BP 1 glucocorticoid receptor signaling pathway 1 P27797 235 1.08e-02 12 3 1 0.333 0.083 GO:0031958 BP 1 corticosteroid receptor signaling pathway 1 P27797 235 1.08e-02 12 3 1 0.333 0.083 GO:0050750 MF 1 low-density lipoprotein particle receptor binding 1 P14625 235 1.08e-02 2060 3 3 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P14625,P27797,P07237 235 1.09e-02 531 3 2 0.667 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 P14625,P07237 235 1.10e-02 2072 3 3 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P14625,P27797,P07237 235 1.12e-02 384 3 2 0.667 0.005 GO:0032403 MF 1 protein complex binding 1 P27797,P07237 235 1.12e-02 385 3 2 0.667 0.005 GO:0019725 BP 1 cellular homeostasis 1 P14625,P27797 235 1.17e-02 13 3 1 0.333 0.077 GO:0036336 BP 1 dendritic cell migration 1 P27797 235 1.21e-02 2139 3 3 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.24e-02 567 3 2 0.667 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P14625,P07237 235 1.24e-02 2159 3 3 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 1.27e-02 2176 3 3 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.29e-02 2188 3 3 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.30e-02 2191 3 3 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.34e-02 15 3 1 0.333 0.067 GO:0048384 BP 1 retinoic acid receptor signaling pathway 1 P27797 235 1.37e-02 2227 3 3 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P14625,P27797,P07237 235 1.41e-02 7 3 1 0.333 0.143 HP:0005547 hp 1 Myeloproliferative disorder 1 P27797 235 1.43e-02 16 3 1 0.333 0.062 GO:0070325 MF 1 lipoprotein particle receptor binding 1 P14625 235 1.45e-02 2270 3 3 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.45e-02 2274 3 3 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.45e-02 2274 3 3 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.46e-02 2276 3 3 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.47e-02 2281 3 3 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.48e-02 2286 3 3 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.48e-02 2290 3 3 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.49e-02 2295 3 3 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.50e-02 1882 3 3 1.000 0.002 GO:0042221 BP 1 response to chemical 1 P14625,P27797,P07237 235 1.50e-02 624 3 2 0.667 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P14625,P07237 235 1.52e-02 2308 3 3 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P14625,P27797,P07237 235 1.52e-02 2310 3 3 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.56e-02 2328 3 3 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.59e-02 2342 3 3 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.64e-02 2366 3 3 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.68e-02 2385 3 3 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.70e-02 2395 3 3 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.70e-02 19 3 1 0.333 0.053 GO:0046596 BP 1 regulation of viral entry into host cell 1 P07237 235 1.70e-02 19 3 1 0.333 0.053 GO:0003756 MF 1 protein disulfide isomerase activity 1 P07237 235 1.70e-02 19 3 1 0.333 0.053 GO:0016864 MF 1 intramolecular oxidoreductase activity, transposing S-S bonds 1 P07237 235 1.70e-02 2397 3 3 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.75e-02 2417 3 3 1.000 0.001 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.77e-02 2429 3 3 1.000 0.001 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.79e-02 2435 3 3 1.000 0.001 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.79e-02 20 3 1 0.333 0.050 GO:0071556 CC 1 integral component of lumenal side of endoplasmic reticulum membrane 1 P27797 235 1.79e-02 20 3 1 0.333 0.050 GO:0098553 CC 1 lumenal side of endoplasmic reticulum membrane 1 P27797 235 1.81e-02 9 3 1 0.333 0.111 HP:0004443 hp 1 Lambdoidal craniosynostosis 1 P07237 235 1.83e-02 2456 3 3 1.000 0.001 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.84e-02 2458 3 3 1.000 0.001 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.86e-02 2469 3 3 1.000 0.001 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.87e-02 2472 3 3 1.000 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.88e-02 499 3 2 0.667 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 P14625,P27797 235 1.88e-02 499 3 2 0.667 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 P14625,P27797 235 1.88e-02 2477 3 3 1.000 0.001 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.92e-02 2495 3 3 1.000 0.001 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.92e-02 2496 3 3 1.000 0.001 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P14625,P27797,P07237 235 1.95e-02 348 3 2 0.667 0.006 TF:M01001_1 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 1 1 P14625,P07237 235 1.97e-02 22 3 1 0.333 0.045 GO:1902175 BP 1 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 P07237 235 1.97e-02 22 3 1 0.333 0.045 GO:0033144 BP 1 negative regulation of intracellular steroid hormone receptor signaling pathway 1 P27797 235 1.98e-02 512 3 2 0.667 0.004 GO:0048878 BP 1 chemical homeostasis 1 P14625,P27797 235 1.99e-02 2071 3 3 1.000 0.001 GO:0006950 BP 1 response to stress 1 P14625,P27797,P07237 235 2.03e-02 519 3 2 0.667 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 P14625,P07237 235 2.06e-02 23 3 1 0.333 0.043 GO:1900026 BP 1 positive regulation of substrate adhesion-dependent cell spreading 1 P27797 235 2.08e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 P14625,P27797,P07237 235 2.10e-02 528 3 2 0.667 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 P14625,P27797 235 2.15e-02 17 3 1 0.333 0.059 REAC:174800 rea 1 Chylomicron-mediated lipid transport 1 P07237 235 2.15e-02 534 3 2 0.667 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 P14625,P27797 235 2.16e-02 753 3 2 0.667 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P14625,P07237 235 2.19e-02 2136 3 3 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 P14625,P27797,P07237 235 2.21e-02 761 3 2 0.667 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P14625,P27797 235 2.24e-02 25 3 1 0.333 0.040 GO:0050766 BP 1 positive regulation of phagocytosis 1 P27797 235 2.24e-02 25 3 1 0.333 0.040 GO:0043666 BP 1 regulation of phosphoprotein phosphatase activity 1 P14625 235 2.33e-02 26 3 1 0.333 0.038 GO:1903513 BP 1 endoplasmic reticulum to cytosol transport 1 P14625 235 2.33e-02 26 3 1 0.333 0.038 GO:0030970 BP 1 retrograde protein transport, ER to cytosol 1 P14625 235 2.33e-02 26 3 1 0.333 0.038 GO:0045740 BP 1 positive regulation of DNA replication 1 P27797 235 2.37e-02 2194 3 3 1.000 0.001 GO:0070062 CC 1 extracellular exosome 1 P14625,P27797,P07237 235 2.41e-02 2205 3 3 1.000 0.001 GO:1903561 CC 1 extracellular vesicle 1 P14625,P27797,P07237 235 2.41e-02 2205 3 3 1.000 0.001 GO:0043230 CC 1 extracellular organelle 1 P14625,P27797,P07237 235 2.58e-02 586 3 2 0.667 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 P14625,P07237 235 2.59e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 P14625,P27797,P07237 235 2.60e-02 29 3 1 0.333 0.034 GO:0002690 BP 1 positive regulation of leukocyte chemotaxis 1 P27797 235 2.64e-02 593 3 2 0.667 0.003 GO:0046872 MF 1 metal ion binding 1 P14625,P27797 235 2.65e-02 836 3 2 0.667 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P14625,P07237 235 2.68e-02 30 3 1 0.333 0.033 GO:0005844 CC 1 polysome 1 P27797 235 2.75e-02 1856 3 3 1.000 0.002 TF:M02021_0 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 0 1 P14625,P27797,P07237 235 2.77e-02 31 3 1 0.333 0.032 GO:0008631 BP 1 intrinsic apoptotic signaling pathway in response to oxidative stress 1 P07237 235 2.77e-02 22 3 1 0.333 0.045 REAC:983170 rea 1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1 P27797 235 2.83e-02 2839 3 3 1.000 0.001 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 2.95e-02 33 3 1 0.333 0.030 GO:0090398 BP 1 cellular senescence 1 P27797 235 2.95e-02 33 3 1 0.333 0.030 GO:1900024 BP 1 regulation of substrate adhesion-dependent cell spreading 1 P27797 235 3.01e-02 6 3 1 0.333 0.167 CORUM:1226 cor 1 H2AX complex I 1 P27797 235 3.01e-02 15 3 1 0.333 0.067 HP:0004420 hp 1 Arterial thrombosis 1 P27797 235 3.03e-02 24 3 1 0.333 0.042 REAC:901042 rea 1 Calnexin/calreticulin cycle 1 P27797 235 3.04e-02 34 3 1 0.333 0.029 GO:1903201 BP 1 regulation of oxidative stress-induced cell death 1 P07237 235 3.06e-02 2914 3 3 1.000 0.001 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 P14625,P27797,P07237 235 3.08e-02 902 3 2 0.667 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P14625,P07237 235 3.09e-02 643 3 2 0.667 0.003 GO:0071495 BP 1 cellular response to endogenous stimulus 1 P14625,P27797 235 3.13e-02 35 3 1 0.333 0.029 GO:0050681 MF 1 androgen receptor binding 1 P27797 235 3.15e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 P14625,P27797,P07237 235 3.19e-02 919 3 2 0.667 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 P14625,P27797 235 3.20e-02 654 3 2 0.667 0.003 GO:0043169 MF 1 cation binding 1 P14625,P27797 235 3.22e-02 36 3 1 0.333 0.028 GO:0002688 BP 1 regulation of leukocyte chemotaxis 1 P27797 235 3.22e-02 36 3 1 0.333 0.028 GO:0046718 BP 1 viral entry into host cell 1 P07237 235 3.22e-02 36 3 1 0.333 0.028 GO:0016706 MF 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 1 P07237 235 3.31e-02 37 3 1 0.333 0.027 GO:0050764 BP 1 regulation of phagocytosis 1 P27797 235 3.34e-02 16 3 1 0.333 0.062 TF:M06249_0 tf 1 Factor: ZNF616; motif: NCGTGGGGGGGA; match class: 0 1 P27797 235 3.40e-02 38 3 1 0.333 0.026 GO:0032527 BP 1 protein exit from endoplasmic reticulum 1 P14625 235 3.40e-02 27 3 1 0.333 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 P07237 235 3.46e-02 958 3 2 0.667 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P14625,P07237 235 3.49e-02 39 3 1 0.333 0.026 GO:0030260 BP 1 entry into host cell 1 P07237 235 3.49e-02 39 3 1 0.333 0.026 GO:0002687 BP 1 positive regulation of leukocyte migration 1 P27797 235 3.49e-02 39 3 1 0.333 0.026 GO:0044409 BP 1 entry into host 1 P07237 235 3.49e-02 39 3 1 0.333 0.026 GO:0051828 BP 1 entry into other organism involved in symbiotic interaction 1 P07237 235 3.49e-02 39 3 1 0.333 0.026 GO:0051806 BP 1 entry into cell of other organism involved in symbiotic interaction 1 P07237 235 3.49e-02 39 3 1 0.333 0.026 GO:0006611 BP 1 protein export from nucleus 1 P27797 235 3.51e-02 965 3 2 0.667 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P14625,P07237 235 3.55e-02 690 3 2 0.667 0.003 GO:0002682 BP 1 regulation of immune system process 1 P14625,P27797 235 3.55e-02 690 3 2 0.667 0.003 GO:0044877 MF 1 macromolecular complex binding 1 P27797,P07237 235 3.58e-02 40 3 1 0.333 0.025 GO:1900407 BP 1 regulation of cellular response to oxidative stress 1 P07237 235 3.59e-02 977 3 2 0.667 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P14625,P07237 235 3.70e-02 2050 3 3 1.000 0.001 TF:M04571_0 tf 1 Factor: TFEC; motif: RNCACRTGAY; match class: 0 1 P14625,P27797,P07237 235 3.71e-02 994 3 2 0.667 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P14625,P07237 235 3.72e-02 995 3 2 0.667 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P14625,P07237 235 3.72e-02 380 3 2 0.667 0.005 MI:hsa-miR-188-3p mi 1 MI:hsa-miR-188-3p 1 P14625,P07237 235 3.74e-02 709 3 2 0.667 0.003 GO:0006886 BP 1 intracellular protein transport 1 P14625,P27797 235 3.75e-02 42 3 1 0.333 0.024 GO:0016860 MF 1 intramolecular oxidoreductase activity 1 P07237 235 3.75e-02 42 3 1 0.333 0.024 GO:1902882 BP 1 regulation of response to oxidative stress 1 P07237 235 3.75e-02 42 3 1 0.333 0.024 GO:0046683 BP 1 response to organophosphorus 1 P14625 235 3.78e-02 712 3 2 0.667 0.003 GO:0009719 BP 1 response to endogenous stimulus 1 P14625,P27797 235 3.78e-02 3127 3 3 1.000 0.001 HPA:022020_02 hpa 1 lung; pneumocytes[Uncertain,Medium] 1 P14625,P27797,P07237 235 3.81e-02 19 3 1 0.333 0.053 HP:0100576 hp 1 Amaurosis fugax 1 P27797 235 3.84e-02 43 3 1 0.333 0.023 GO:0035304 BP 1 regulation of protein dephosphorylation 1 P14625 235 3.84e-02 43 3 1 0.333 0.023 GO:0010811 BP 1 positive regulation of cell-substrate adhesion 1 P27797 235 3.84e-02 43 3 1 0.333 0.023 GO:0033143 BP 1 regulation of intracellular steroid hormone receptor signaling pathway 1 P27797 235 3.93e-02 44 3 1 0.333 0.023 GO:0036473 BP 1 cell death in response to oxidative stress 1 P07237 235 3.93e-02 44 3 1 0.333 0.023 GO:0014074 BP 1 response to purine-containing compound 1 P14625 235 4.00e-02 2612 3 3 1.000 0.001 GO:1901363 MF 1 heterocyclic compound binding 1 P14625,P27797,P07237 235 4.00e-02 8 3 1 0.333 0.125 CORUM:1227 cor 1 H2AX complex II 1 P27797 235 4.01e-02 20 3 1 0.333 0.050 HP:0010299 hp 1 Abnormality of dentin 1 P07237 235 4.07e-02 2627 3 3 1.000 0.001 GO:0044421 CC 1 extracellular region part 1 P14625,P27797,P07237 235 4.08e-02 3208 3 3 1.000 0.001 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.15e-02 33 3 1 0.333 0.030 REAC:532668 rea 1 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 1 P27797 235 4.21e-02 21 3 1 0.333 0.048 HP:0004440 hp 1 Coronal craniosynostosis 1 P07237 235 4.23e-02 2660 3 3 1.000 0.001 GO:0097159 MF 1 organic cyclic compound binding 1 P14625,P27797,P07237 235 4.23e-02 3247 3 3 1.000 0.001 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.34e-02 1078 3 2 0.667 0.002 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 P14625,P07237 235 4.34e-02 1078 3 2 0.667 0.002 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P14625,P07237 235 4.40e-02 22 3 1 0.333 0.045 HP:0000586 hp 1 Shallow orbits 1 P07237 235 4.40e-02 22 3 1 0.333 0.045 HP:3000030 hp 1 Abnormality of bony orbit of skull 1 P07237 235 4.47e-02 50 3 1 0.333 0.020 GO:0007569 BP 1 cell aging 1 P27797 235 4.55e-02 783 3 2 0.667 0.003 GO:0042592 BP 1 homeostatic process 1 P14625,P27797 235 4.55e-02 3326 3 3 1.000 0.001 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.55e-02 3326 3 3 1.000 0.001 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.58e-02 3334 3 3 1.000 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.60e-02 23 3 1 0.333 0.043 HP:0011869 hp 1 Abnormal platelet function 1 P27797 235 4.60e-02 23 3 1 0.333 0.043 HP:0003540 hp 1 Impaired platelet aggregation 1 P27797 235 4.60e-02 23 3 1 0.333 0.043 HP:0100749 hp 1 Chest pain 1 P27797 235 4.60e-02 23 3 1 0.333 0.043 HP:0030402 hp 1 Abnormal platelet aggregation 1 P27797 235 4.63e-02 3344 3 3 1.000 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.63e-02 3344 3 3 1.000 0.001 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.63e-02 2743 3 3 1.000 0.001 GO:0005576 CC 1 extracellular region 1 P14625,P27797,P07237 235 4.64e-02 52 3 1 0.333 0.019 GO:0030246 MF 1 carbohydrate binding 1 P27797 235 4.67e-02 3355 3 3 1.000 0.001 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.68e-02 1121 3 2 0.667 0.002 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P14625,P07237 235 4.70e-02 3361 3 3 1.000 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.73e-02 3368 3 3 1.000 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.73e-02 53 3 1 0.333 0.019 GO:0035258 MF 1 steroid hormone receptor binding 1 P27797 235 4.73e-02 3370 3 3 1.000 0.001 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.75e-02 1129 3 2 0.667 0.002 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P14625,P07237 235 4.77e-02 3379 3 3 1.000 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.78e-02 1133 3 2 0.667 0.002 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P14625,P07237 235 4.80e-02 3386 3 3 1.000 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.80e-02 3386 3 3 1.000 0.001 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.80e-02 3386 3 3 1.000 0.001 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.82e-02 3390 3 3 1.000 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.82e-02 54 3 1 0.333 0.019 GO:0050921 BP 1 positive regulation of chemotaxis 1 P27797 235 4.87e-02 3403 3 3 1.000 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.88e-02 3405 3 3 1.000 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.89e-02 436 3 2 0.667 0.005 MI:hsa-miR-31 mi 1 MI:hsa-miR-31 1 P14625,P27797 235 4.89e-02 3407 3 3 1.000 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.89e-02 3407 3 3 1.000 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.90e-02 2795 3 3 1.000 0.001 GO:0031982 CC 1 vesicle 1 P14625,P27797,P07237 235 4.91e-02 814 3 2 0.667 0.002 GO:0080134 BP 1 regulation of response to stress 1 P14625,P07237 235 4.91e-02 55 3 1 0.333 0.018 GO:0051213 MF 1 dioxygenase activity 1 P07237 235 4.91e-02 3412 3 3 1.000 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.92e-02 3413 3 3 1.000 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.93e-02 3415 3 3 1.000 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.93e-02 3416 3 3 1.000 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.93e-02 3416 3 3 1.000 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.93e-02 3416 3 3 1.000 0.001 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.94e-02 3418 3 3 1.000 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.95e-02 3420 3 3 1.000 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.95e-02 3421 3 3 1.000 0.001 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.96e-02 3422 3 3 1.000 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.96e-02 3422 3 3 1.000 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.96e-02 3423 3 3 1.000 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.96e-02 3423 3 3 1.000 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.97e-02 3424 3 3 1.000 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.97e-02 3426 3 3 1.000 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.97e-02 3426 3 3 1.000 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.98e-02 3428 3 3 1.000 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.99e-02 3429 3 3 1.000 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.99e-02 3429 3 3 1.000 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.99e-02 3429 3 3 1.000 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 4.99e-02 3430 3 3 1.000 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3431 3 3 1.000 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3432 3 3 1.000 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3432 3 3 1.000 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 549 3 2 0.667 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 P14625,P27797 235 5.00e-02 3432 3 3 1.000 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 56 3 1 0.333 0.018 GO:0002685 BP 1 regulation of leukocyte migration 1 P27797 235 5.00e-02 441 3 2 0.667 0.005 MI:hsa-miR-650 mi 1 MI:hsa-miR-650 1 P27797,P07237 235 5.00e-02 1 3 1 0.333 1.000 OMIM:112240 omi 1 Cole-Carpenter Syndrome 1 P07237 235 5.00e-02 45 3 1 0.333 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P27797 235 5.00e-02 25 3 1 0.333 0.040 HP:0001894 hp 1 Thrombocytosis 1 P27797 235 5.00e-02 3432 3 3 1.000 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 10 3 1 0.333 0.100 CORUM:1223 cor 1 H2AX complex, isolated from cells without IR exposure 1 P27797 235 5.00e-02 3432 3 3 1.000 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3432 3 3 1.000 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 3432 3 3 1.000 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P14625,P27797,P07237 235 5.00e-02 25 3 1 0.333 0.040 HP:0002953 hp 1 Vertebral compression fractures 1 P07237 236 4.47e-03 312 4 2 0.500 0.006 MI:hsa-miR-196a* mi 1 MI:hsa-miR-196a* 1 Q8N490,Q9HAP2 236 8.36e-03 1 4 1 0.250 1.000 OMIM:118800 omi 1 PAROXYSMAL NONKINESIGENIC DYSKINESIA 1; PNKD1;;PAROXYSMAL DYSTONIC CHOREOATHETOSIS; PDC;;CHOREOATHETOSIS, FAMILIAL PAROXYSMAL; FPD1;;MOUNT-REBACK SYNDROME;;CHOREOATHETOSIS, NONKINESIGENIC;;DYSTONIA 8; DYT8 1 Q8N490 236 9.00e-03 446 4 2 0.500 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q8N490,Q9HAP2 236 9.16e-03 450 4 2 0.500 0.004 MI:hsa-miR-557 mi 1 MI:hsa-miR-557 1 Q6P2P2,Q9HAP2 236 1.03e-02 478 4 2 0.500 0.004 MI:hsa-miR-9 mi 1 MI:hsa-miR-9 1 Q8N490,Q9HAP2 236 2.00e-02 2 4 1 0.250 0.500 TF:M04362_1 tf 1 Factor: HOXD12; motif: RGTCGTAAAAN; match class: 1 1 Q6P2P2 236 4.00e-02 4 4 1 0.250 0.250 TF:M04364_1 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 1 1 Q6P2P2 236 4.00e-02 4 4 1 0.250 0.250 HP:0002268 hp 1 Paroxysmal dystonia 1 Q8N490 236 4.13e-02 42 4 1 0.250 0.024 REAC:2151201 rea 1 Transcriptional activation of mitochondrial biogenesis 1 Q86YN6 236 5.00e-02 5 4 1 0.250 0.200 TF:M04358_1 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 1 1 Q6P2P2 236 5.00e-02 6 4 1 0.250 0.167 OMIM:601665 omi 1 OBESITYLEANNESS, INCLUDED 1 Q86YN6 236 5.00e-02 1 4 1 0.250 1.000 GO:0100024 BP 1 regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter 1 Q9HAP2 236 5.00e-02 5 4 1 0.250 0.200 TF:M04342_1 tf 1 Factor: HOXA13; motif: NCTCGTAAAAN; match class: 1 1 Q6P2P2 236 5.00e-02 1 4 1 0.250 1.000 GO:0050682 MF 1 AF-2 domain binding 1 Q86YN6 236 5.00e-02 51 4 1 0.250 0.020 REAC:1592230 rea 1 Mitochondrial biogenesis 1 Q86YN6 236 5.00e-02 5 4 1 0.250 0.200 TF:M04346_1 tf 1 Factor: HOXB13; motif: NCTCGTAAAAN; match class: 1 1 Q6P2P2 236 5.00e-02 96 4 2 0.500 0.021 KEGG:04931 keg 1 Insulin resistance 1 Q86YN6,Q9HAP2 236 5.00e-02 5 4 1 0.250 0.200 HP:0007098 hp 1 Paroxysmal choreoathetosis 1 Q8N490 236 5.00e-02 1 4 1 0.250 1.000 GO:1900402 BP 1 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter 1 Q9HAP2 237 3.67e-03 12 4 2 0.500 0.167 HP:0003541 hp 1 Urinary glycosaminoglycan excretion 1 P22304,Q8NBK3 237 3.67e-03 12 4 2 0.500 0.167 HP:0008155 hp 1 Mucopolysacchariduria 1 P22304,Q8NBK3 237 4.33e-03 13 4 2 0.500 0.154 HP:0004371 hp 1 Abnormality of glycosaminoglycan metabolism 1 P22304,Q8NBK3 237 4.33e-03 13 4 2 0.500 0.154 HP:0011012 hp 1 Abnormality of polysaccharide metabolism 1 P22304,Q8NBK3 237 4.33e-03 13 4 2 0.500 0.154 HP:0011020 hp 1 Abnormality of mucopolysaccharide metabolism 1 P22304,Q8NBK3 237 5.05e-03 14 4 2 0.500 0.143 HP:0000943 hp 1 Dysostosis multiplex 1 P22304,Q8NBK3 237 1.36e-02 111 4 2 0.500 0.018 KEGG:04142 keg 1 Lysosome 1 P22304,Q8NBK3 237 4.09e-02 9 4 1 0.250 0.111 REAC:1663150 rea 1 The activation of arylsulfatases 1 Q8NBK3 237 5.00e-02 1 4 1 0.250 1.000 GO:0004423 MF 1 iduronate-2-sulfatase activity 1 P22304 237 5.00e-02 552 4 3 0.750 0.005 TF:M00104_1 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 1 1 Q9Y2S7,O94952,Q8NBK3 237 5.00e-02 11 4 1 0.250 0.091 REAC:2024101 rea 1 CS/DS degradation 1 P22304 237 5.00e-02 1 4 1 0.250 1.000 HP:0007307 hp 1 Rapid neurologic deterioration 1 Q8NBK3 237 5.00e-02 13 4 1 0.250 0.077 KEGG:00531 keg 1 Glycosaminoglycan degradation 1 P22304 237 5.00e-02 1 4 1 0.250 1.000 OMIM:309900 omi 1 MUCOPOLYSACCHARIDOSIS, TYPE II; MPS2;;MPS II;;HUNTER SYNDROME;;IDURONATE 2-SULFATASE DEFICIENCY;;IDS DEFICIENCY;;SULFOIDURONATE SULFATASE DEFICIENCY;;SIDS DEFICIENCY 1 P22304 237 5.00e-02 1 4 1 0.250 1.000 OMIM:272200 omi 1 MULTIPLE SULFATASE DEFICIENCY; MSD;;MUCOSULFATIDOSIS;;SULFATIDOSIS, JUVENILE, AUSTIN TYPE 1 Q8NBK3 238 2.73e-03 3 2 1 0.500 0.333 GO:0019797 MF 1 procollagen-proline 3-dioxygenase activity 1 Q8IVL6 238 3.64e-03 4 2 1 0.500 0.250 GO:0031544 MF 1 peptidyl-proline 3-dioxygenase activity 1 Q8IVL6 238 5.47e-03 6 2 1 0.500 0.167 GO:0019798 MF 1 procollagen-proline dioxygenase activity 1 Q8IVL6 238 6.38e-03 7 2 1 0.500 0.143 GO:0007130 BP 1 synaptonemal complex assembly 1 Q92791 238 6.38e-03 7 2 1 0.500 0.143 GO:0070193 BP 1 synaptonemal complex organization 1 Q92791 238 9.11e-03 10 2 1 0.500 0.100 GO:0031543 MF 1 peptidyl-proline dioxygenase activity 1 Q8IVL6 238 9.11e-03 10 2 1 0.500 0.100 GO:0007129 BP 1 synapsis 1 Q92791 238 9.70e-03 40 2 1 0.500 0.025 TF:M03939_1 tf 1 Factor: ZNF740; motif: CCCCCCCCAC; match class: 1 1 Q8IVL6 238 1.36e-02 1196 2 2 1.000 0.002 TF:M03846_1 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 1 1 Q8IVL6,Q92791 238 1.41e-02 1217 2 2 1.000 0.002 TF:M07261_1 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 1 Q8IVL6,Q92791 238 1.43e-02 1225 2 2 1.000 0.002 TF:M00807_1 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 1 Q8IVL6,Q92791 238 1.45e-02 60 2 1 0.500 0.017 TF:M05573_0 tf 1 Factor: ZNF213; motif: NATGCCTRCMGM; match class: 0 1 Q8IVL6 238 1.46e-02 16 2 1 0.500 0.062 GO:0045143 BP 1 homologous chromosome segregation 1 Q92791 238 1.50e-02 62 2 1 0.500 0.016 TF:M05714_0 tf 1 Factor: Evi-1; motif: KGGTCMMAACTN; match class: 0 1 Q92791 238 1.55e-02 17 2 1 0.500 0.059 GO:0000795 CC 1 synaptonemal complex 1 Q92791 238 1.55e-02 17 2 1 0.500 0.059 GO:0099086 CC 1 synaptonemal structure 1 Q92791 238 1.98e-02 82 2 1 0.500 0.012 TF:M07410_1 tf 1 Factor: RFX2; motif: GTYNCCATGGCAACNGNNN; match class: 1 1 Q8IVL6 238 2.08e-02 86 2 1 0.500 0.012 TF:M05441_0 tf 1 Factor: ZNF396; motif: KGGTGAGGAAGA; match class: 0 1 Q92791 238 2.09e-02 23 2 1 0.500 0.043 GO:0070192 BP 1 chromosome organization involved in meiotic cell cycle 1 Q92791 238 2.23e-02 92 2 1 0.500 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 Q8IVL6 238 2.45e-02 1602 2 2 1.000 0.001 TF:M00938_0 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 0 1 Q8IVL6,Q92791 238 2.66e-02 110 2 1 0.500 0.009 TF:M04097_1 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 1 1 Q8IVL6 238 2.97e-02 1764 2 2 1.000 0.001 TF:M01592_0 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 0 1 Q8IVL6,Q92791 238 3.00e-02 33 2 1 0.500 0.030 GO:0045132 BP 1 meiotic chromosome segregation 1 Q92791 238 3.15e-02 1818 2 2 1.000 0.001 TF:M07062_0 tf 1 Factor: RREB1; motif: GRSDSGGGKTGGGKGG; match class: 0 1 Q8IVL6,Q92791 238 3.28e-02 36 2 1 0.500 0.028 GO:0016706 MF 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 1 Q8IVL6 238 3.57e-02 148 2 1 0.500 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 Q92791 238 3.68e-02 1966 2 2 1.000 0.001 TF:M07356_0 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 0 1 Q8IVL6,Q92791 238 3.69e-02 56 2 1 0.500 0.018 REAC:1650814 rea 1 Collagen biosynthesis and modifying enzymes 1 Q8IVL6 238 3.76e-02 156 2 1 0.500 0.006 TF:M04515_0 tf 1 Factor: E2F1; motif: WWTGGCGCCAAA; match class: 0 1 Q8IVL6 238 3.79e-02 157 2 1 0.500 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q8IVL6 238 3.84e-02 159 2 1 0.500 0.006 TF:M06290_0 tf 1 Factor: Cos52; motif: NGGTCCDCCWGW; match class: 0 1 Q8IVL6 238 4.20e-02 2098 2 2 1.000 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q8IVL6,Q92791 238 4.25e-02 2111 2 2 1.000 0.001 TF:M01009_0 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 0 1 Q8IVL6,Q92791 238 4.34e-02 180 2 1 0.500 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 Q8IVL6 238 4.58e-02 190 2 1 0.500 0.005 TF:M01592_1 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 1 Q8IVL6 238 4.60e-02 191 2 1 0.500 0.005 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 Q92791 238 4.72e-02 341 2 2 1.000 0.006 MI:hsa-miR-645 mi 1 MI:hsa-miR-645 1 Q8IVL6,Q92791 238 4.78e-02 2238 2 2 1.000 0.001 TF:M00918_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 Q8IVL6,Q92791 238 4.82e-02 200 2 1 0.500 0.005 TF:M00997_1 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 1 1 Q8IVL6 238 4.82e-02 53 2 1 0.500 0.019 GO:0007127 BP 1 meiosis I 1 Q92791 238 4.99e-02 2288 2 2 1.000 0.001 TF:M00919_0 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 0 1 Q8IVL6,Q92791 238 5.00e-02 351 2 2 1.000 0.006 MI:gga-miR-456 mi 1 MI:gga-miR-456 1 Q8IVL6,Q92791 238 5.00e-02 55 2 1 0.500 0.018 GO:0051213 MF 1 dioxygenase activity 1 Q8IVL6 238 5.00e-02 76 2 1 0.500 0.013 REAC:1474290 rea 1 Collagen formation 1 Q8IVL6 238 5.00e-02 2290 2 2 1.000 0.001 TF:M07347_0 tf 1 Factor: AhR; motif: NNNKNGCGTGNSNNNNN; match class: 0 1 Q8IVL6,Q92791 238 5.00e-02 55 2 1 0.500 0.018 GO:0000794 CC 1 condensed nuclear chromosome 1 Q92791 239 2.64e-07 2 4 2 0.500 1.000 GO:0030692 CC 1 Noc4p-Nop14p complex 1 P78316,Q9BVI4 239 7.91e-07 3 4 2 0.500 0.667 GO:0030689 CC 1 Noc complex 1 P78316,Q9BVI4 239 3.95e-06 6 4 2 0.500 0.333 GO:0030688 CC 1 preribosome, small subunit precursor 1 P78316,Q9BVI4 239 8.55e-05 26 4 2 0.500 0.077 GO:0030686 CC 1 90S preribosome 1 P78316,Q9BVI4 239 8.90e-05 229 4 3 0.750 0.013 GO:0006364 BP 1 rRNA processing 1 P78316,Q13895,Q9BVI4 239 9.25e-05 232 4 3 0.750 0.013 GO:0016072 BP 1 rRNA metabolic process 1 P78316,Q13895,Q9BVI4 239 1.30e-04 32 4 2 0.500 0.062 GO:0032040 CC 1 small-subunit processome 1 P78316,Q9BVI4 239 1.40e-04 200 4 3 0.750 0.015 REAC:72312 rea 1 rRNA processing 1 P78316,Q13895,Q9BVI4 239 1.56e-04 35 4 2 0.500 0.057 GO:0000462 BP 1 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316,Q9BVI4 239 1.59e-04 278 4 3 0.750 0.011 GO:0042254 BP 1 ribosome biogenesis 1 P78316,Q13895,Q9BVI4 239 2.72e-04 46 4 2 0.500 0.043 GO:0030490 BP 1 maturation of SSU-rRNA 1 P78316,Q9BVI4 239 3.11e-04 348 4 3 0.750 0.009 GO:0034470 BP 1 ncRNA processing 1 P78316,Q13895,Q9BVI4 239 4.51e-04 394 4 3 0.750 0.008 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 P78316,Q13895,Q9BVI4 239 4.79e-04 61 4 2 0.500 0.033 GO:0042274 BP 1 ribosomal small subunit biogenesis 1 P78316,Q9BVI4 239 6.14e-04 69 4 2 0.500 0.029 GO:0030684 CC 1 preribosome 1 P78316,Q9BVI4 239 8.73e-04 492 4 3 0.750 0.006 GO:0034660 BP 1 ncRNA metabolic process 1 P78316,Q13895,Q9BVI4 239 1.01e-03 1 4 1 0.250 1.000 GO:0034038 MF 1 deoxyhypusine synthase activity 1 P49366 239 1.01e-03 1 4 1 0.250 1.000 GO:0050983 BP 1 obsolete deoxyhypusine biosynthetic process from spermidine 1 P49366 239 1.95e-03 645 4 3 0.750 0.005 GO:0005730 CC 1 nucleolus 1 P78316,Q13895,Q9BVI4 239 2.20e-03 7 4 1 0.250 0.143 TF:M06602_1 tf 1 Factor: ZNF669; motif: NCGATTTTAWTT; match class: 1 1 P78316 239 3.04e-03 3 4 1 0.250 0.333 GO:0034471 BP 1 ncRNA 5'-end processing 1 P78316 239 3.04e-03 3 4 1 0.250 0.333 GO:0000967 BP 1 rRNA 5'-end processing 1 P78316 239 3.04e-03 3 4 1 0.250 0.333 GO:0000472 BP 1 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316 239 3.07e-03 752 4 3 0.750 0.004 GO:0006396 BP 1 RNA processing 1 P78316,Q13895,Q9BVI4 239 3.77e-03 4 4 1 0.250 0.250 REAC:204626 rea 1 Hypusine synthesis from eIF5A-lysine 1 P49366 239 4.05e-03 4 4 1 0.250 0.250 GO:0008612 BP 1 peptidyl-lysine modification to peptidyl-hypusine 1 P49366 239 4.05e-03 4 4 1 0.250 0.250 GO:0000480 BP 1 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316 239 4.39e-03 14 4 1 0.250 0.071 TF:M00466_1 tf 1 Factor: HIF1; motif: NGTACGTGCNGB; match class: 1 1 Q9BVI4 239 5.96e-03 19 4 1 0.250 0.053 TF:M05542_0 tf 1 Factor: SNAP190; motif: CTTSMGTATTA; match class: 0 1 P49366 239 6.08e-03 6 4 1 0.250 0.167 GO:0000966 BP 1 RNA 5'-end processing 1 P78316 239 6.08e-03 6 4 1 0.250 0.167 GO:0000447 BP 1 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316 239 6.77e-03 438 4 2 0.500 0.005 TF:M06049_0 tf 1 Factor: ZNF208; motif: NGNGGGAGTTCM; match class: 0 1 P49366,Q9BVI4 239 7.83e-03 25 4 1 0.250 0.040 TF:M03952_1 tf 1 Factor: CDP; motif: TRATCRATAN; match class: 1 1 Q13895 239 8.77e-03 28 4 1 0.250 0.036 TF:M03954_1 tf 1 Factor: CUX2; motif: TRATCGATAN; match class: 1 1 Q13895 239 8.81e-03 3901 4 4 1.000 0.001 TF:M01269_1 tf 1 Factor: NURR1; motif: YRRCCTT; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 9.08e-03 29 4 1 0.250 0.034 TF:M06629_0 tf 1 Factor: ZNF578; motif: NGAACCWKCCGA; match class: 0 1 P78316 239 9.85e-03 1118 4 3 0.750 0.003 GO:0044822 MF 1 poly(A) RNA binding 1 P78316,Q13895,Q9BVI4 239 1.01e-02 10 4 1 0.250 0.100 GO:0000479 BP 1 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316 239 1.05e-02 4080 4 4 1.000 0.001 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 1.11e-02 11 4 1 0.250 0.091 GO:0000478 BP 1 endonucleolytic cleavage involved in rRNA processing 1 P78316 239 1.19e-02 585 4 2 0.500 0.003 TF:M00621_1 tf 1 Factor: C/EBPdelta; motif: MATTKCNTMAYY; match class: 1 1 P49366,Q13895 239 1.30e-02 1963 4 3 0.750 0.002 TF:M07256_0 tf 1 Factor: FXR:RXR; motif: RGGTCANTGACCTN; match class: 0 1 P78316,P49366,Q13895 239 1.38e-02 44 4 1 0.250 0.023 TF:M00102_1 tf 1 Factor: CDP; motif: NWNATCGATTANYNN; match class: 1 1 Q13895 239 1.41e-02 45 4 1 0.250 0.022 TF:M06556_0 tf 1 Factor: znf383; motif: KGGAAGGTAAGC; match class: 0 1 P78316 239 1.44e-02 3058 4 4 1.000 0.001 GO:0010467 BP 1 gene expression 1 P78316,P49366,Q13895,Q9BVI4 239 1.62e-02 16 4 1 0.250 0.062 GO:0090502 BP 1 RNA phosphodiester bond hydrolysis, endonucleolytic 1 P78316 239 1.66e-02 1336 4 3 0.750 0.002 GO:0003723 MF 1 RNA binding 1 P78316,Q13895,Q9BVI4 239 1.74e-02 4622 4 4 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 1.78e-02 720 4 2 0.500 0.003 TF:M02268_0 tf 1 Factor: INSM1; motif: TGYCAGGGGGCR; match class: 0 1 Q13895,Q9BVI4 239 1.79e-02 2199 4 3 0.750 0.001 TF:M07394_0 tf 1 Factor: slug; motif: CACCTGNNN; match class: 0 1 P49366,Q13895,Q9BVI4 239 1.82e-02 18 4 1 0.250 0.056 GO:0000466 BP 1 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 P78316 239 1.84e-02 59 4 1 0.250 0.017 TF:M06346_0 tf 1 Factor: E4F1; motif: GTSCCGTAATNM; match class: 0 1 P49366 239 2.00e-02 64 4 1 0.250 0.016 TF:M06002_0 tf 1 Factor: ZNF257; motif: NGGGWGGGCARM; match class: 0 1 P78316 239 2.03e-02 65 4 1 0.250 0.015 TF:M06787_0 tf 1 Factor: ZNF780B; motif: KGTGGAAAAAGM; match class: 0 1 Q9BVI4 239 2.12e-02 21 4 1 0.250 0.048 GO:0000469 BP 1 cleavage involved in rRNA processing 1 P78316 239 2.15e-02 69 4 1 0.250 0.014 TF:M06263_0 tf 1 Factor: ZNF211; motif: NGTGACWAAGSM; match class: 0 1 Q9BVI4 239 2.27e-02 818 4 2 0.500 0.002 TF:M04238_1 tf 1 Factor: FOXD2; motif: NRNWAATATTTAYN; match class: 1 1 P78316,Q13895 239 2.34e-02 2416 4 3 0.750 0.001 TF:M00965_0 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 0 1 P78316,P49366,Q13895 239 2.43e-02 78 4 1 0.250 0.013 TF:M07339_1 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 1 1 P78316 239 2.43e-02 78 4 1 0.250 0.013 TF:M01261_1 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 1 1 P78316 239 2.44e-02 2451 4 3 0.750 0.001 TF:M00076_1 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 1 1 P78316,P49366,Q9BVI4 239 2.47e-02 5047 4 4 1.000 0.001 TF:M05467_0 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 0 1 P78316,P49366,Q13895,Q9BVI4 239 2.63e-02 26 4 1 0.250 0.038 GO:0030515 MF 1 snoRNA binding 1 P78316 239 2.72e-02 29 4 1 0.250 0.034 REAC:163841 rea 1 Gamma carboxylation, hypusine formation and arylsulfatase activation 1 P49366 239 2.83e-02 91 4 1 0.250 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 Q13895 239 3.03e-02 30 4 1 0.250 0.033 GO:0000460 BP 1 maturation of 5.8S rRNA 1 P78316 239 3.03e-02 953 4 2 0.500 0.002 TF:M04193_1 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 1 1 P49366,Q9BVI4 239 3.08e-02 99 4 1 0.250 0.010 TF:M04162_0 tf 1 Factor: BHLHE40; motif: NKCACGTGMC; match class: 0 1 P49366 239 3.08e-02 99 4 1 0.250 0.010 TF:M04188_0 tf 1 Factor: SREBF2; motif: ATCACGTGAY; match class: 0 1 P49366 239 3.17e-02 102 4 1 0.250 0.010 TF:M04172_0 tf 1 Factor: HEY1; motif: GRCACGTGCC; match class: 0 1 P78316 239 3.17e-02 102 4 1 0.250 0.010 TF:M04173_0 tf 1 Factor: HEY2; motif: GNCACGTGYN; match class: 0 1 P78316 239 3.19e-02 5379 4 4 1.000 0.001 TF:M02071_1 tf 1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 3.23e-02 104 4 1 0.250 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 P78316 239 3.44e-02 111 4 1 0.250 0.009 TF:M06003_0 tf 1 Factor: ZNF257; motif: NTGGWGGGCAKM; match class: 0 1 Q9BVI4 239 3.73e-02 37 4 1 0.250 0.027 GO:0007565 BP 1 female pregnancy 1 Q13895 239 3.75e-02 2855 4 3 0.750 0.001 TF:M00955_0 tf 1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 0 1 P78316,P49366,Q13895 239 3.77e-02 2861 4 3 0.750 0.001 TF:M02053_0 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 0 1 P49366,Q13895,Q9BVI4 239 3.78e-02 122 4 1 0.250 0.008 TF:M04178_0 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 0 1 P49366 239 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 P49366,Q13895 239 3.89e-02 2893 4 3 0.750 0.001 TF:M04617_1 tf 1 Factor: LRF; motif: NGNAGNGGGTYN; match class: 1 1 P78316,P49366,Q13895 239 3.97e-02 1099 4 2 0.500 0.002 TF:M07339_0 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 0 1 P78316,P49366 239 4.01e-02 3948 4 4 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P78316,P49366,Q13895,Q9BVI4 239 4.13e-02 41 4 1 0.250 0.024 GO:0044706 BP 1 multi-multicellular organism process 1 Q13895 239 4.21e-02 1133 4 2 0.500 0.002 TF:M00514_0 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 0 1 P49366,Q9BVI4 239 4.21e-02 136 4 1 0.250 0.007 TF:M01002_1 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 1 1 P78316 239 4.32e-02 3003 4 3 0.750 0.001 TF:M00432_1 tf 1 Factor: TTF1; motif: ASTCAAGTRK; match class: 1 1 P78316,P49366,Q13895 239 4.40e-02 599 4 2 0.500 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P78316,Q9BVI4 239 4.42e-02 600 4 2 0.500 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 P78316,Q9BVI4 239 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P49366,Q13895 239 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P49366,Q13895 239 4.50e-02 5864 4 4 1.000 0.001 TF:M02070_1 tf 1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 4.51e-02 1176 4 2 0.500 0.002 TF:M01261_0 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 0 1 P78316,Q13895 239 4.60e-02 1188 4 2 0.500 0.002 TF:M01968_1 tf 1 Factor: FOXO1; motif: TGTTKAC; match class: 1 1 Q13895,Q9BVI4 239 4.80e-02 1932 4 3 0.750 0.002 GO:0044085 BP 1 cellular component biogenesis 1 P78316,Q13895,Q9BVI4 239 4.81e-02 156 4 1 0.250 0.006 TF:M00113_1 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 1 1 Q9BVI4 239 4.84e-02 48 4 1 0.250 0.021 GO:0090501 BP 1 RNA phosphodiester bond hydrolysis 1 P78316 239 4.90e-02 159 4 1 0.250 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 Q9BVI4 239 4.90e-02 159 4 1 0.250 0.006 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 Q9BVI4 239 4.94e-02 6001 4 4 1.000 0.001 TF:M03582_1 tf 1 Factor: TWIST; motif: CACCTGG; match class: 1 1 P78316,P49366,Q13895,Q9BVI4 239 4.94e-02 332 4 2 0.500 0.006 MI:hsa-miR-545* mi 1 MI:hsa-miR-545* 1 P78316,Q13895 239 4.96e-02 3156 4 3 0.750 0.001 TF:M07041_1 tf 1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 1 P78316,P49366,Q9BVI4 239 5.00e-02 1960 4 3 0.750 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P78316,Q13895,Q9BVI4 239 5.00e-02 1960 4 3 0.750 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P78316,Q13895,Q9BVI4 239 5.00e-02 1485 4 3 0.750 0.002 REAC:74160 rea 1 Gene Expression 1 P78316,Q13895,Q9BVI4 239 5.00e-02 334 4 2 0.500 0.006 MI:hsa-miR-380* mi 1 MI:hsa-miR-380* 1 P78316,P49366 240 9.83e-11 5 3 3 1.000 0.600 GO:1904885 BP 1 beta-catenin destruction complex assembly 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:4839748 rea 1 AMER1 mutants destabilize the destruction complex 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:5467348 rea 1 Truncations of AMER1 destabilize the destruction complex 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:4839744 rea 1 truncated APC mutants destabilize the destruction complex 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:5467340 rea 1 AXIN missense mutants destabilize the destruction complex 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:5467337 rea 1 APC truncation mutants have impaired AXIN binding 1 O15169,P25054,Q5JTC6 240 1.07e-08 14 3 3 1.000 0.214 REAC:4839735 rea 1 AXIN mutants destabilize the destruction complex, activating WNT signaling 1 O15169,P25054,Q5JTC6 240 1.12e-08 20 3 3 1.000 0.150 GO:1904886 BP 1 beta-catenin destruction complex disassembly 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:5358751 rea 1 S45 mutants of beta-catenin aren't phosphorylated 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:5339716 rea 1 Misspliced GSK3beta mutants stabilize beta-catenin 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:5358747 rea 1 S33 mutants of beta-catenin aren't phosphorylated 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:5358749 rea 1 S37 mutants of beta-catenin aren't phosphorylated 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:5358752 rea 1 T41 mutants of beta-catenin aren't phosphorylated 1 O15169,P25054,Q5JTC6 240 1.33e-08 15 3 3 1.000 0.200 REAC:4839743 rea 1 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1 O15169,P25054,Q5JTC6 240 1.99e-08 17 3 3 1.000 0.176 REAC:196299 rea 1 Beta-catenin phosphorylation cascade 1 O15169,P25054,Q5JTC6 240 8.56e-08 27 3 3 1.000 0.111 REAC:4791275 rea 1 Signaling by WNT in cancer 1 O15169,P25054,Q5JTC6 240 1.07e-07 29 3 3 1.000 0.103 REAC:4641262 rea 1 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1 O15169,P25054,Q5JTC6 240 2.72e-07 56 3 3 1.000 0.054 GO:0008013 MF 1 beta-catenin binding 1 O15169,P25054,Q5JTC6 240 2.50e-06 81 3 3 1.000 0.037 REAC:195253 rea 1 Degradation of beta-catenin by the destruction complex 1 O15169,P25054,Q5JTC6 240 2.62e-06 118 3 3 1.000 0.025 GO:0090090 BP 1 negative regulation of canonical Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 4.12e-06 137 3 3 1.000 0.022 GO:0030178 BP 1 negative regulation of Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 6.84e-06 162 3 3 1.000 0.019 GO:0060828 BP 1 regulation of canonical Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 8.84e-06 13 3 2 0.667 0.154 GO:0030877 CC 1 beta-catenin destruction complex 1 O15169,P25054 240 1.02e-05 185 3 3 1.000 0.016 GO:0043241 BP 1 protein complex disassembly 1 O15169,P25054,Q5JTC6 240 1.12e-05 191 3 3 1.000 0.016 GO:0045732 BP 1 positive regulation of protein catabolic process 1 O15169,P25054,Q5JTC6 240 1.12e-05 191 3 3 1.000 0.016 GO:0060070 BP 1 canonical Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 1.47e-05 209 3 3 1.000 0.014 GO:0032984 BP 1 macromolecular complex disassembly 1 O15169,P25054,Q5JTC6 240 1.50e-05 210 3 3 1.000 0.014 GO:0030111 BP 1 regulation of Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 1.87e-05 3 3 2 0.667 0.667 CORUM:3004 cor 1 APC-Axin-1-beta-catenin complex 1 O15169,P25054 240 2.15e-05 165 3 3 1.000 0.018 REAC:201681 rea 1 TCF dependent signaling in response to WNT 1 O15169,P25054,Q5JTC6 240 2.15e-05 237 3 3 1.000 0.013 GO:0009896 BP 1 positive regulation of catabolic process 1 O15169,P25054,Q5JTC6 240 2.86e-05 23 3 2 0.667 0.087 GO:0016328 CC 1 lateral plasma membrane 1 O15169,P25054 240 3.08e-05 267 3 3 1.000 0.011 GO:0042176 BP 1 regulation of protein catabolic process 1 O15169,P25054,Q5JTC6 240 3.74e-05 4 3 2 0.667 0.500 CORUM:3166 cor 1 AXIN-APC-betaCatenin-GSK3B complex 1 O15169,P25054 240 3.81e-05 8 3 2 0.667 0.250 OMIM:114550 omi 1 HEPATOCELLULAR CARCINOMA;;HCC;;CANCER, HEPATOCELLULAR;;LIVER CANCER;;LIVER CELL CARCINOMA; LCC;;HEPATOMAHEPATOBLASTOMA, INCLUDED;;HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION, INCLUDED 1 O15169,P25054 240 4.42e-05 301 3 3 1.000 0.010 GO:0198738 BP 1 cell-cell signaling by wnt 1 O15169,P25054,Q5JTC6 240 4.42e-05 301 3 3 1.000 0.010 GO:0016055 BP 1 Wnt signaling pathway 1 O15169,P25054,Q5JTC6 240 4.69e-05 307 3 3 1.000 0.010 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 O15169,P25054,Q5JTC6 240 5.47e-05 323 3 3 1.000 0.009 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 O15169,P25054,Q5JTC6 240 5.57e-05 325 3 3 1.000 0.009 GO:0010498 BP 1 proteasomal protein catabolic process 1 O15169,P25054,Q5JTC6 240 6.73e-05 35 3 2 0.667 0.057 GO:0005881 CC 1 cytoplasmic microtubule 1 O15169,P25054 240 6.96e-05 350 3 3 1.000 0.009 GO:0009894 BP 1 regulation of catabolic process 1 O15169,P25054,Q5JTC6 240 7.26e-05 247 3 3 1.000 0.012 REAC:195721 rea 1 Signaling by Wnt 1 O15169,P25054,Q5JTC6 240 1.07e-04 404 3 3 1.000 0.007 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 O15169,P25054,Q5JTC6 240 1.10e-04 408 3 3 1.000 0.007 GO:0019941 BP 1 modification-dependent protein catabolic process 1 O15169,P25054,Q5JTC6 240 1.17e-04 416 3 3 1.000 0.007 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 O15169,P25054,Q5JTC6 240 1.26e-04 426 3 3 1.000 0.007 GO:0022411 BP 1 cellular component disassembly 1 O15169,P25054,Q5JTC6 240 1.42e-04 309 3 3 1.000 0.010 REAC:5663202 rea 1 Diseases of signal transduction 1 O15169,P25054,Q5JTC6 240 1.57e-04 459 3 3 1.000 0.007 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 O15169,P25054,Q5JTC6 240 1.85e-04 484 3 3 1.000 0.006 GO:0044257 BP 1 cellular protein catabolic process 1 O15169,P25054,Q5JTC6 240 2.86e-04 560 3 3 1.000 0.005 GO:0030163 BP 1 protein catabolic process 1 O15169,P25054,Q5JTC6 240 2.97e-04 73 3 2 0.667 0.027 GO:0045165 BP 1 cell fate commitment 1 O15169,P25054 240 4.21e-04 637 3 3 1.000 0.005 GO:0009968 BP 1 negative regulation of signal transduction 1 O15169,P25054,Q5JTC6 240 4.52e-04 90 3 2 0.667 0.022 GO:0090263 BP 1 positive regulation of canonical Wnt signaling pathway 1 O15169,Q5JTC6 240 4.71e-04 661 3 3 1.000 0.005 GO:0010648 BP 1 negative regulation of cell communication 1 O15169,P25054,Q5JTC6 240 4.80e-04 665 3 3 1.000 0.005 GO:0023057 BP 1 negative regulation of signaling 1 O15169,P25054,Q5JTC6 240 6.27e-04 727 3 3 1.000 0.004 GO:0044265 BP 1 cellular macromolecule catabolic process 1 O15169,P25054,Q5JTC6 240 6.54e-04 1 3 1 0.333 1.000 GO:0001743 BP 1 optic placode formation 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0021877 BP 1 forebrain neuron fate commitment 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0048319 BP 1 axial mesoderm morphogenesis 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0021898 BP 1 commitment of multipotent stem cells to neuronal lineage in forebrain 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0021881 BP 1 Wnt-activated signaling pathway involved in forebrain neuron fate commitment 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0060823 BP 1 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0048320 BP 1 axial mesoderm formation 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0021797 BP 1 forebrain anterior/posterior pattern specification 1 O15169 240 6.54e-04 1 3 1 0.333 1.000 GO:0048318 BP 1 axial mesoderm development 1 O15169 240 6.58e-04 37 3 2 0.667 0.054 KEGG:05217 keg 1 Basal cell carcinoma 1 O15169,P25054 240 6.99e-04 754 3 3 1.000 0.004 GO:0007267 BP 1 cell-cell signaling 1 O15169,P25054,Q5JTC6 240 7.38e-04 115 3 2 0.667 0.017 GO:0030177 BP 1 positive regulation of Wnt signaling pathway 1 O15169,Q5JTC6 240 7.59e-04 775 3 3 1.000 0.004 GO:0048585 BP 1 negative regulation of response to stimulus 1 O15169,P25054,Q5JTC6 240 7.64e-04 1 3 1 0.333 1.000 REAC:5467345 rea 1 Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling 1 O15169 240 7.64e-04 1 3 1 0.333 1.000 REAC:5467343 rea 1 Deletions in the AMER1 gene destabilize the destruction complex 1 Q5JTC6 240 7.64e-04 1 3 1 0.333 1.000 REAC:5467333 rea 1 APC truncation mutants are not K63 polyubiquitinated 1 P25054 240 7.64e-04 117 3 2 0.667 0.017 GO:0007389 BP 1 pattern specification process 1 O15169,P25054 240 8.29e-04 8 3 2 0.667 0.250 HP:0006572 hp 1 Subacute progressive viral hepatitis 1 O15169,P25054 240 9.74e-04 842 3 3 1.000 0.004 GO:0070271 BP 1 protein complex biogenesis 1 O15169,P25054,Q5JTC6 240 9.74e-04 842 3 3 1.000 0.004 GO:0006461 BP 1 protein complex assembly 1 O15169,P25054,Q5JTC6 240 1.10e-03 876 3 3 1.000 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 O15169,P25054,Q5JTC6 240 1.11e-03 141 3 2 0.667 0.014 GO:0031398 BP 1 positive regulation of protein ubiquitination 1 O15169,Q5JTC6 240 1.11e-03 880 3 3 1.000 0.003 GO:0051247 BP 1 positive regulation of protein metabolic process 1 O15169,P25054,Q5JTC6 240 1.16e-03 49 3 2 0.667 0.041 KEGG:05213 keg 1 Endometrial cancer 1 O15169,P25054 240 1.21e-03 147 3 2 0.667 0.014 GO:1903364 BP 1 positive regulation of cellular protein catabolic process 1 O15169,Q5JTC6 240 1.31e-03 2 3 1 0.333 0.500 GO:0071698 BP 1 olfactory placode development 1 O15169 240 1.31e-03 2 3 1 0.333 0.500 GO:0030910 BP 1 olfactory placode formation 1 O15169 240 1.31e-03 2 3 1 0.333 0.500 GO:0071699 BP 1 olfactory placode morphogenesis 1 O15169 240 1.31e-03 2 3 1 0.333 0.500 GO:1904713 MF 1 beta-catenin destruction complex binding 1 Q5JTC6 240 1.34e-03 155 3 2 0.667 0.013 GO:1903322 BP 1 positive regulation of protein modification by small protein conjugation or removal 1 O15169,Q5JTC6 240 1.34e-03 937 3 3 1.000 0.003 GO:0006508 BP 1 proteolysis 1 O15169,P25054,Q5JTC6 240 1.48e-03 967 3 3 1.000 0.003 GO:0031399 BP 1 regulation of protein modification process 1 O15169,P25054,Q5JTC6 240 1.54e-03 166 3 2 0.667 0.012 GO:0005874 CC 1 microtubule 1 O15169,P25054 240 1.63e-03 11 3 2 0.667 0.182 HP:0006562 hp 1 Viral hepatitis 1 O15169,P25054 240 1.63e-03 58 3 2 0.667 0.034 KEGG:05210 keg 1 Colorectal cancer 1 O15169,P25054 240 1.71e-03 1015 3 3 1.000 0.003 GO:0071822 BP 1 protein complex subunit organization 1 O15169,P25054,Q5JTC6 240 1.74e-03 1 3 1 0.333 1.000 OMIM:135290 omi 1 DESMOID DISEASE, HEREDITARY;;FIBROMATOSIS, FAMILIAL INFILTRATIVE; FIFDESMOID TUMOR CAUSED BY SOMATIC MUTATION, INCLUDED 1 P25054 240 1.74e-03 1 3 1 0.333 1.000 OMIM:300373 omi 1 OSTEOPATHIA STRIATA WITH CRANIAL SCLEROSIS; OSCS;;HYPEROSTOSIS GENERALISATA WITH STRIATIONS 1 Q5JTC6 240 1.74e-03 1 3 1 0.333 1.000 OMIM:607864 omi 1 CAUDAL DUPLICATION ANOMALY 1 O15169 240 1.81e-03 720 3 3 1.000 0.004 REAC:1643685 rea 1 Disease 1 O15169,P25054,Q5JTC6 240 2.01e-03 190 3 2 0.667 0.011 GO:0031396 BP 1 regulation of protein ubiquitination 1 O15169,Q5JTC6 240 2.03e-03 191 3 2 0.667 0.010 GO:1903362 BP 1 regulation of cellular protein catabolic process 1 O15169,Q5JTC6 240 2.23e-03 200 3 2 0.667 0.010 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 O15169,Q5JTC6 240 2.25e-03 1113 3 3 1.000 0.003 GO:0065003 BP 1 macromolecular complex assembly 1 O15169,P25054,Q5JTC6 240 2.43e-03 1141 3 3 1.000 0.003 GO:0044248 BP 1 cellular catabolic process 1 O15169,P25054,Q5JTC6 240 2.43e-03 209 3 2 0.667 0.010 GO:1903320 BP 1 regulation of protein modification by small protein conjugation or removal 1 O15169,Q5JTC6 240 2.61e-03 4 3 1 0.333 0.250 GO:0060897 BP 1 neural plate regionalization 1 O15169 240 2.61e-03 4 3 1 0.333 0.250 GO:0021871 BP 1 forebrain regionalization 1 O15169 240 2.61e-03 4 3 1 0.333 0.250 GO:0021999 BP 1 neural plate anterior/posterior regionalization 1 O15169 240 2.61e-03 4 3 1 0.333 0.250 GO:0072498 BP 1 embryonic skeletal joint development 1 O15169 240 2.61e-03 4 3 1 0.333 0.250 GO:0060272 BP 1 embryonic skeletal joint morphogenesis 1 O15169 240 3.10e-03 15 3 2 0.667 0.133 HP:0001413 hp 1 Micronodular cirrhosis 1 O15169,P25054 240 3.27e-03 5 3 1 0.333 0.200 GO:0090244 BP 1 Wnt signaling pathway involved in somitogenesis 1 O15169 240 3.27e-03 5 3 1 0.333 0.200 GO:0060896 BP 1 neural plate pattern specification 1 O15169 240 3.27e-03 5 3 1 0.333 0.200 GO:0071696 BP 1 ectodermal placode development 1 O15169 240 3.27e-03 5 3 1 0.333 0.200 GO:0060788 BP 1 ectodermal placode formation 1 O15169 240 3.27e-03 5 3 1 0.333 0.200 GO:0043584 BP 1 nose development 1 O15169 240 3.27e-03 5 3 1 0.333 0.200 GO:0071697 BP 1 ectodermal placode morphogenesis 1 O15169 240 3.48e-03 2 3 1 0.333 0.500 OMIM:175100 omi 1 Familial Adenomatous Polyposis 1 P25054 240 3.51e-03 1290 3 3 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 O15169,P25054,Q5JTC6 240 3.92e-03 6 3 1 0.333 0.167 GO:0031274 BP 1 positive regulation of pseudopodium assembly 1 P25054 240 3.92e-03 6 3 1 0.333 0.167 GO:0034244 BP 1 negative regulation of transcription elongation from RNA polymerase II promoter 1 O15169 240 3.92e-03 6 3 1 0.333 0.167 GO:0031272 BP 1 regulation of pseudopodium assembly 1 P25054 240 3.92e-03 6 3 1 0.333 0.167 GO:0031269 BP 1 pseudopodium assembly 1 P25054 240 3.93e-03 266 3 2 0.667 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 O15169,P25054 240 3.95e-03 1342 3 3 1.000 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 O15169,P25054,Q5JTC6 240 4.11e-03 272 3 2 0.667 0.007 GO:0031329 BP 1 regulation of cellular catabolic process 1 O15169,Q5JTC6 240 4.13e-03 1362 3 3 1.000 0.002 GO:0009056 BP 1 catabolic process 1 O15169,P25054,Q5JTC6 240 4.17e-03 274 3 2 0.667 0.007 GO:0099512 CC 1 supramolecular fiber 1 O15169,P25054 240 4.17e-03 274 3 2 0.667 0.007 GO:0099081 CC 1 supramolecular polymer 1 O15169,P25054 240 4.23e-03 276 3 2 0.667 0.007 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 O15169,P25054 240 4.52e-03 18 3 2 0.667 0.111 HP:0001402 hp 1 Hepatocellular carcinoma 1 O15169,P25054 240 4.57e-03 7 3 1 0.333 0.143 GO:0016342 CC 1 catenin complex 1 P25054 240 4.57e-03 7 3 1 0.333 0.143 GO:0031268 BP 1 pseudopodium organization 1 P25054 240 4.64e-03 1416 3 3 1.000 0.002 GO:0007166 BP 1 cell surface receptor signaling pathway 1 O15169,P25054,Q5JTC6 240 4.66e-03 1804 3 3 1.000 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 O15169,P25054,Q5JTC6 240 4.80e-03 294 3 2 0.667 0.007 GO:0099080 CC 1 supramolecular complex 1 O15169,P25054 240 4.90e-03 1442 3 3 1.000 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 O15169,P25054,Q5JTC6 240 4.94e-03 21 3 1 0.333 0.048 TF:M00665_1 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 1 Q5JTC6 240 5.23e-03 8 3 1 0.333 0.125 GO:0070411 MF 1 I-SMAD binding 1 O15169 240 5.23e-03 8 3 1 0.333 0.125 GO:0032785 BP 1 negative regulation of DNA-templated transcription, elongation 1 O15169 240 5.65e-03 108 3 2 0.667 0.019 KEGG:04550 keg 1 Signaling pathways regulating pluripotency of stem cells 1 O15169,P25054 240 5.88e-03 9 3 1 0.333 0.111 GO:0051010 MF 1 microtubule plus-end binding 1 P25054 240 5.88e-03 9 3 1 0.333 0.111 GO:1990909 CC 1 Wnt signalosome 1 P25054 240 5.88e-03 9 3 1 0.333 0.111 GO:0048663 BP 1 neuron fate commitment 1 O15169 240 6.04e-03 330 3 2 0.667 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 O15169,P25054 240 6.08e-03 112 3 2 0.667 0.018 KEGG:05224 keg 1 Breast cancer 1 O15169,P25054 240 6.10e-03 495 3 2 0.667 0.004 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 O15169,Q5JTC6 240 6.36e-03 1573 3 3 1.000 0.002 GO:0009966 BP 1 regulation of signal transduction 1 O15169,P25054,Q5JTC6 240 6.37e-03 339 3 2 0.667 0.006 GO:0019901 MF 1 protein kinase binding 1 O15169,P25054 240 6.48e-03 2013 3 3 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 6.53e-03 10 3 1 0.333 0.100 GO:0048048 BP 1 embryonic eye morphogenesis 1 O15169 240 6.53e-03 10 3 1 0.333 0.100 GO:0045295 MF 1 gamma-catenin binding 1 P25054 240 6.53e-03 10 3 1 0.333 0.100 GO:0009950 BP 1 dorsal/ventral axis specification 1 O15169 240 6.86e-03 119 3 2 0.667 0.017 KEGG:04310 keg 1 Wnt signaling pathway 1 O15169,P25054 240 6.87e-03 1614 3 3 1.000 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 O15169,P25054,Q5JTC6 240 7.18e-03 11 3 1 0.333 0.091 GO:0051988 BP 1 regulation of attachment of spindle microtubules to kinetochore 1 P25054 240 7.18e-03 11 3 1 0.333 0.091 GO:0007026 BP 1 negative regulation of microtubule depolymerization 1 P25054 240 7.18e-03 11 3 1 0.333 0.091 GO:0001756 BP 1 somitogenesis 1 O15169 240 7.18e-03 11 3 1 0.333 0.091 GO:0031114 BP 1 regulation of microtubule depolymerization 1 P25054 240 7.26e-03 1644 3 3 1.000 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 O15169,P25054,Q5JTC6 240 7.84e-03 12 3 1 0.333 0.083 GO:0070016 MF 1 armadillo repeat domain binding 1 O15169 240 7.91e-03 1691 3 3 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 O15169,P25054,Q5JTC6 240 7.93e-03 128 3 2 0.667 0.016 KEGG:04390 keg 1 Hippo signaling pathway 1 O15169,P25054 240 8.12e-03 1706 3 3 1.000 0.002 GO:0022607 BP 1 cellular component assembly 1 O15169,P25054,Q5JTC6 240 8.23e-03 386 3 2 0.667 0.005 GO:0019900 MF 1 kinase binding 1 O15169,P25054 240 8.44e-03 1728 3 3 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 O15169,P25054,Q5JTC6 240 8.46e-03 689 3 2 0.667 0.003 TF:M01596_0 tf 1 Factor: Gli3; motif: STGGGTGGYCY; match class: 0 1 O15169,Q5JTC6 240 8.69e-03 1745 3 3 1.000 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 O15169,P25054,Q5JTC6 240 8.70e-03 37 3 1 0.333 0.027 TF:M06762_0 tf 1 Factor: ZNF222; motif: NGGTCRAAACGA; match class: 0 1 P25054 240 8.70e-03 5 3 1 0.333 0.200 OMIM:613659 omi 1 GASTRIC CANCERGASTRIC CANCER, INTESTINAL, INCLUDED 1 P25054 240 8.92e-03 402 3 2 0.667 0.005 GO:0045859 BP 1 regulation of protein kinase activity 1 O15169,P25054 240 8.93e-03 708 3 2 0.667 0.003 TF:M04174_0 tf 1 Factor: ID4; motif: NRCACCTGNN; match class: 0 1 O15169,Q5JTC6 240 9.14e-03 14 3 1 0.333 0.071 GO:0001708 BP 1 cell fate specification 1 P25054 240 9.14e-03 14 3 1 0.333 0.071 GO:1904030 BP 1 negative regulation of cyclin-dependent protein kinase activity 1 P25054 240 9.14e-03 14 3 1 0.333 0.071 GO:0010800 BP 1 positive regulation of peptidyl-threonine phosphorylation 1 O15169 240 9.14e-03 14 3 1 0.333 0.071 GO:0045736 BP 1 negative regulation of cyclin-dependent protein serine/threonine kinase activity 1 P25054 240 9.26e-03 2674 3 3 1.000 0.001 TF:M01714_0 tf 1 Factor: KLF15; motif: GAGNNGGGGNGTDG; match class: 0 1 O15169,P25054,Q5JTC6 240 9.81e-03 743 3 2 0.667 0.003 TF:M05381_0 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 0 1 P25054,Q5JTC6 240 1.03e-02 44 3 1 0.333 0.023 TF:M05882_1 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 1 1 P25054 240 1.03e-02 27 3 2 0.667 0.074 HP:0012115 hp 1 Hepatitis 1 O15169,P25054 240 1.04e-02 16 3 1 0.333 0.062 GO:0035412 BP 1 regulation of catenin import into nucleus 1 O15169 240 1.04e-02 16 3 1 0.333 0.062 GO:0031111 BP 1 negative regulation of microtubule polymerization or depolymerization 1 P25054 240 1.06e-02 439 3 2 0.667 0.005 GO:0043549 BP 1 regulation of kinase activity 1 O15169,P25054 240 1.09e-02 2392 3 3 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 1.11e-02 17 3 1 0.333 0.059 GO:0035411 BP 1 catenin import into nucleus 1 O15169 240 1.13e-02 48 3 1 0.333 0.021 TF:M00063_0 tf 1 Factor: IRF-2; motif: GAAAAGYGAAASY; match class: 0 1 Q5JTC6 240 1.16e-02 459 3 2 0.667 0.004 GO:0007017 BP 1 microtubule-based process 1 O15169,P25054 240 1.17e-02 2454 3 3 1.000 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 O15169,P25054,Q5JTC6 240 1.17e-02 462 3 2 0.667 0.004 GO:0016567 BP 1 protein ubiquitination 1 O15169,Q5JTC6 240 1.18e-02 1932 3 3 1.000 0.002 GO:0044085 BP 1 cellular component biogenesis 1 O15169,P25054,Q5JTC6 240 1.24e-02 19 3 1 0.333 0.053 GO:0001707 BP 1 mesoderm formation 1 O15169 240 1.24e-02 19 3 1 0.333 0.053 GO:0021879 BP 1 forebrain neuron differentiation 1 O15169 240 1.24e-02 19 3 1 0.333 0.053 GO:0034243 BP 1 regulation of transcription elongation from RNA polymerase II promoter 1 O15169 240 1.25e-02 2953 3 3 1.000 0.001 TF:M00231_0 tf 1 Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 0 1 O15169,P25054,Q5JTC6 240 1.28e-02 2527 3 3 1.000 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 O15169,P25054,Q5JTC6 240 1.29e-02 854 3 2 0.667 0.002 TF:M07095_0 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 0 1 P25054,Q5JTC6 240 1.31e-02 20 3 1 0.333 0.050 GO:0048332 BP 1 mesoderm morphogenesis 1 O15169 240 1.31e-02 20 3 1 0.333 0.050 GO:0035282 BP 1 segmentation 1 O15169 240 1.31e-02 20 3 1 0.333 0.050 GO:0061053 BP 1 somite development 1 O15169 240 1.31e-02 20 3 1 0.333 0.050 GO:0048704 BP 1 embryonic skeletal system morphogenesis 1 O15169 240 1.34e-02 57 3 1 0.333 0.018 TF:M05335_0 tf 1 Factor: egr-3; motif: GGGCGKGGGCGG; match class: 0 1 O15169 240 1.37e-02 2582 3 3 1.000 0.001 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 O15169,P25054,Q5JTC6 240 1.37e-02 21 3 1 0.333 0.048 GO:0021872 BP 1 forebrain generation of neurons 1 O15169 240 1.40e-02 891 3 2 0.667 0.002 TF:M00210_0 tf 1 Factor: OCT-x; motif: CTNATTTGCATAY; match class: 0 1 P25054,Q5JTC6 240 1.43e-02 2 3 1 0.333 0.500 CORUM:933 cor 1 SCRIB-APC complex 1 P25054 240 1.43e-02 2 3 1 0.333 0.500 CORUM:3168 cor 1 DAXX-AXIN complex 1 O15169 240 1.43e-02 2 3 1 0.333 0.500 CORUM:2968 cor 1 Axin-SMAD3 complex 1 O15169 240 1.43e-02 2 3 1 0.333 0.500 CORUM:1909 cor 1 APC-DLG4 complex 1 P25054 240 1.44e-02 22 3 1 0.333 0.045 GO:0007019 BP 1 microtubule depolymerization 1 P25054 240 1.45e-02 62 3 1 0.333 0.016 TF:M02113_0 tf 1 Factor: OCA-B; motif: ATATGCAAATC; match class: 0 1 P25054 240 1.50e-02 23 3 1 0.333 0.043 GO:0045599 BP 1 negative regulation of fat cell differentiation 1 O15169 240 1.50e-02 23 3 1 0.333 0.043 GO:0007094 BP 1 mitotic spindle assembly checkpoint 1 P25054 240 1.50e-02 23 3 1 0.333 0.043 GO:0010799 BP 1 regulation of peptidyl-threonine phosphorylation 1 O15169 240 1.50e-02 23 3 1 0.333 0.043 GO:0007257 BP 1 activation of JUN kinase activity 1 O15169 240 1.52e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 O15169,P25054,Q5JTC6 240 1.52e-02 3152 3 3 1.000 0.001 TF:M04379_1 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 1 1 O15169,P25054,Q5JTC6 240 1.55e-02 66 3 1 0.333 0.015 TF:M03907_1 tf 1 Factor: HINFP; motif: CNRCGTCCGCNN; match class: 1 1 O15169 240 1.55e-02 33 3 2 0.667 0.061 HP:0002896 hp 1 Neoplasm of the liver 1 O15169,P25054 240 1.57e-02 24 3 1 0.333 0.042 GO:0071173 BP 1 spindle assembly checkpoint 1 P25054 240 1.63e-02 25 3 1 0.333 0.040 GO:0071174 BP 1 mitotic spindle checkpoint 1 P25054 240 1.63e-02 25 3 1 0.333 0.040 GO:0045841 BP 1 negative regulation of mitotic metaphase/anaphase transition 1 P25054 240 1.63e-02 25 3 1 0.333 0.040 GO:2000816 BP 1 negative regulation of mitotic sister chromatid separation 1 P25054 240 1.70e-02 26 3 1 0.333 0.038 GO:1902100 BP 1 negative regulation of metaphase/anaphase transition of cell cycle 1 P25054 240 1.73e-02 2791 3 3 1.000 0.001 HPA:007020_02 hpa 1 cerebral cortex; glial cells[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 1.76e-02 75 3 1 0.333 0.013 TF:M00224_1 tf 1 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN; match class: 1 1 P25054 240 1.76e-02 27 3 1 0.333 0.037 GO:0009953 BP 1 dorsal/ventral pattern formation 1 O15169 240 1.76e-02 27 3 1 0.333 0.037 GO:0033048 BP 1 negative regulation of mitotic sister chromatid segregation 1 P25054 240 1.76e-02 27 3 1 0.333 0.037 GO:0048706 BP 1 embryonic skeletal system development 1 O15169 240 1.76e-02 27 3 1 0.333 0.037 GO:1901880 BP 1 negative regulation of protein depolymerization 1 P25054 240 1.76e-02 27 3 1 0.333 0.037 GO:0008608 BP 1 attachment of spindle microtubules to kinetochore 1 P25054 240 1.80e-02 573 3 2 0.667 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 O15169,Q5JTC6 240 1.82e-02 577 3 2 0.667 0.003 GO:0051338 BP 1 regulation of transferase activity 1 O15169,P25054 240 1.85e-02 582 3 2 0.667 0.003 GO:0030234 MF 1 enzyme regulator activity 1 O15169,P25054 240 1.88e-02 3384 3 3 1.000 0.001 TF:M03811_1 tf 1 Factor: AP-2gamma; motif: GCCYNCRGSN; match class: 1 1 O15169,P25054,Q5JTC6 240 1.89e-02 29 3 1 0.333 0.034 GO:0033046 BP 1 negative regulation of sister chromatid segregation 1 P25054 240 1.89e-02 29 3 1 0.333 0.034 GO:0009798 BP 1 axis specification 1 O15169 240 1.89e-02 29 3 1 0.333 0.034 GO:0043242 BP 1 negative regulation of protein complex disassembly 1 P25054 240 1.90e-02 1575 3 3 1.000 0.002 REAC:162582 rea 1 Signal Transduction 1 O15169,P25054,Q5JTC6 240 1.93e-02 2275 3 3 1.000 0.001 GO:0036211 BP 1 protein modification process 1 O15169,P25054,Q5JTC6 240 1.93e-02 2275 3 3 1.000 0.001 GO:0006464 BP 1 cellular protein modification process 1 O15169,P25054,Q5JTC6 240 1.94e-02 83 3 1 0.333 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 O15169 240 1.96e-02 30 3 1 0.333 0.033 GO:0070830 BP 1 bicellular tight junction assembly 1 P25054 240 1.96e-02 30 3 1 0.333 0.033 GO:0031122 BP 1 cytoplasmic microtubule organization 1 O15169 240 1.96e-02 30 3 1 0.333 0.033 GO:0031110 BP 1 regulation of microtubule polymerization or depolymerization 1 P25054 240 1.96e-02 30 3 1 0.333 0.033 GO:0031577 BP 1 spindle checkpoint 1 P25054 240 1.96e-02 30 3 1 0.333 0.033 GO:0051985 BP 1 negative regulation of chromosome segregation 1 P25054 240 2.09e-02 32 3 1 0.333 0.031 GO:0000281 BP 1 mitotic cytokinesis 1 P25054 240 2.13e-02 91 3 1 0.333 0.011 TF:M05748_0 tf 1 Factor: ZNF697; motif: NTGGGCRTCGGC; match class: 0 1 O15169 240 2.13e-02 2353 3 3 1.000 0.001 GO:0048856 BP 1 anatomical structure development 1 O15169,P25054,Q5JTC6 240 2.15e-02 3 3 1 0.333 0.333 CORUM:3170 cor 1 Daxx-Axin-p53 complex 1 O15169 240 2.15e-02 3 3 1 0.333 0.333 CORUM:1812 cor 1 AXIN-MEKK4-CCD1 complex 1 O15169 240 2.15e-02 3 3 1 0.333 0.333 CORUM:1828 cor 1 TGF-beta receptor I-Axin-SMAD3 complex 1 O15169 240 2.15e-02 3 3 1 0.333 0.333 CORUM:2844 cor 1 Axin-p53-HIPK2 complex 1 O15169 240 2.15e-02 33 3 1 0.333 0.030 GO:0045839 BP 1 negative regulation of mitotic nuclear division 1 P25054 240 2.22e-02 34 3 1 0.333 0.029 GO:1901879 BP 1 regulation of protein depolymerization 1 P25054 240 2.22e-02 95 3 1 0.333 0.011 TF:M06111_0 tf 1 Factor: ZNF254; motif: NGKTGCGGACGM; match class: 0 1 O15169 240 2.25e-02 96 3 1 0.333 0.010 TF:M07120_0 tf 1 Factor: Oct-2; motif: NNNATTTGCATRT; match class: 0 1 P25054 240 2.28e-02 35 3 1 0.333 0.029 GO:0030071 BP 1 regulation of mitotic metaphase/anaphase transition 1 P25054 240 2.30e-02 650 3 2 0.667 0.003 GO:0031401 BP 1 positive regulation of protein modification process 1 O15169,Q5JTC6 240 2.31e-02 2417 3 3 1.000 0.001 GO:0043412 BP 1 macromolecule modification 1 O15169,P25054,Q5JTC6 240 2.32e-02 2420 3 3 1.000 0.001 GO:0005886 CC 1 plasma membrane 1 O15169,P25054,Q5JTC6 240 2.35e-02 36 3 1 0.333 0.028 GO:1902099 BP 1 regulation of metaphase/anaphase transition of cell cycle 1 P25054 240 2.35e-02 36 3 1 0.333 0.028 GO:0032784 BP 1 regulation of DNA-templated transcription, elongation 1 O15169 240 2.35e-02 36 3 1 0.333 0.028 GO:0007498 BP 1 mesoderm development 1 O15169 240 2.35e-02 2432 3 3 1.000 0.001 GO:0048523 BP 1 negative regulation of cellular process 1 O15169,P25054,Q5JTC6 240 2.39e-02 662 3 2 0.667 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 O15169,Q5JTC6 240 2.41e-02 37 3 1 0.333 0.027 GO:0043507 BP 1 positive regulation of JUN kinase activity 1 O15169 240 2.41e-02 37 3 1 0.333 0.027 GO:0009952 BP 1 anterior/posterior pattern specification 1 O15169 240 2.41e-02 37 3 1 0.333 0.027 GO:0010965 BP 1 regulation of mitotic sister chromatid separation 1 P25054 240 2.41e-02 37 3 1 0.333 0.027 GO:0043297 BP 1 apical junction assembly 1 P25054 240 2.41e-02 37 3 1 0.333 0.027 GO:0007091 BP 1 metaphase/anaphase transition of mitotic cell cycle 1 P25054 240 2.41e-02 37 3 1 0.333 0.027 GO:0061640 BP 1 cytoskeleton-dependent cytokinesis 1 P25054 240 2.41e-02 37 3 1 0.333 0.027 GO:0060541 BP 1 respiratory system development 1 O15169 240 2.41e-02 37 3 1 0.333 0.027 GO:0051784 BP 1 negative regulation of nuclear division 1 P25054 240 2.43e-02 104 3 1 0.333 0.010 TF:M05700_0 tf 1 Factor: ZNF19; motif: KGGGGCTGCTGC; match class: 0 1 O15169 240 2.46e-02 2469 3 3 1.000 0.001 GO:0071944 CC 1 cell periphery 1 O15169,P25054,Q5JTC6 240 2.48e-02 38 3 1 0.333 0.026 GO:0044784 BP 1 metaphase/anaphase transition of cell cycle 1 P25054 240 2.48e-02 38 3 1 0.333 0.026 GO:0051306 BP 1 mitotic sister chromatid separation 1 P25054 240 2.53e-02 1025 3 2 0.667 0.002 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 O15169,Q5JTC6 240 2.54e-02 39 3 1 0.333 0.026 GO:0006921 BP 1 cellular component disassembly involved in execution phase of apoptosis 1 P25054 240 2.55e-02 1028 3 2 0.667 0.002 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 O15169,Q5JTC6 240 2.55e-02 109 3 1 0.333 0.009 TF:M06775_0 tf 1 Factor: ZNF391; motif: NGGGTGAGGGTC; match class: 0 1 Q5JTC6 240 2.61e-02 40 3 1 0.333 0.025 GO:0032587 CC 1 ruffle membrane 1 P25054 240 2.61e-02 40 3 1 0.333 0.025 GO:0005923 CC 1 bicellular tight junction 1 P25054 240 2.61e-02 3775 3 3 1.000 0.001 TF:M05439_1 tf 1 Factor: RREB-1; motif: GGGWCSA; match class: 1 1 O15169,P25054,Q5JTC6 240 2.62e-02 1229 3 2 0.667 0.002 TF:M01116_0 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 0 1 O15169,Q5JTC6 240 2.66e-02 35 3 1 0.333 0.029 REAC:3769402 rea 1 Deactivation of the beta-catenin transactivating complex 1 P25054 240 2.66e-02 700 3 2 0.667 0.003 GO:0001932 BP 1 regulation of protein phosphorylation 1 O15169,P25054 240 2.66e-02 700 3 2 0.667 0.003 GO:0045595 BP 1 regulation of cell differentiation 1 O15169,P25054 240 2.67e-02 41 3 1 0.333 0.024 GO:0005546 MF 1 phosphatidylinositol-4,5-bisphosphate binding 1 Q5JTC6 240 2.67e-02 41 3 1 0.333 0.024 GO:0048592 BP 1 eye morphogenesis 1 O15169 240 2.67e-02 41 3 1 0.333 0.024 GO:0070160 CC 1 occluding junction 1 P25054 240 2.68e-02 1055 3 2 0.667 0.002 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 O15169,P25054 240 2.71e-02 116 3 1 0.333 0.009 TF:M05781_0 tf 1 Factor: ZNF699; motif: NTGTCGGGCAGM; match class: 0 1 O15169 240 2.73e-02 117 3 1 0.333 0.009 TF:M00225_0 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 0 1 P25054 240 2.74e-02 42 3 1 0.333 0.024 GO:0048705 BP 1 skeletal system morphogenesis 1 O15169 240 2.81e-02 2580 3 3 1.000 0.001 GO:0032502 BP 1 developmental process 1 O15169,P25054,Q5JTC6 240 2.81e-02 37 3 1 0.333 0.027 REAC:111465 rea 1 Apoptotic cleavage of cellular proteins 1 P25054 240 2.86e-02 4 3 1 0.333 0.250 CORUM:2842 cor 1 DAXX-Axin-p53-HIPK2 complex 1 O15169 240 2.86e-02 4 3 1 0.333 0.250 CORUM:2998 cor 1 Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex 1 O15169 240 2.87e-02 44 3 1 0.333 0.023 GO:0033047 BP 1 regulation of mitotic sister chromatid segregation 1 P25054 240 2.87e-02 44 3 1 0.333 0.023 GO:0046332 MF 1 SMAD binding 1 O15169 240 2.88e-02 3900 3 3 1.000 0.001 TF:M07226_0 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 0 1 O15169,P25054,Q5JTC6 240 2.89e-02 124 3 1 0.333 0.008 TF:M05825_0 tf 1 Factor: ZNF572; motif: NGGTAGDGAAGC; match class: 0 1 P25054 240 2.91e-02 3915 3 3 1.000 0.001 TF:M01854_0 tf 1 Factor: AML2; motif: CCRCACCAYDN; match class: 0 1 O15169,P25054,Q5JTC6 240 2.93e-02 45 3 1 0.333 0.022 GO:0007368 BP 1 determination of left/right symmetry 1 O15169 240 2.93e-02 45 3 1 0.333 0.022 GO:0043244 BP 1 regulation of protein complex disassembly 1 P25054 240 2.94e-02 2618 3 3 1.000 0.001 GO:0048519 BP 1 negative regulation of biological process 1 O15169,P25054,Q5JTC6 240 3.00e-02 46 3 1 0.333 0.022 GO:0045598 BP 1 regulation of fat cell differentiation 1 O15169 240 3.00e-02 46 3 1 0.333 0.022 GO:0043506 BP 1 regulation of JUN kinase activity 1 O15169 240 3.08e-02 3386 3 3 1.000 0.001 HPA:006030_02 hpa 1 cerebellum; cells in molecular layer[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 3.11e-02 758 3 2 0.667 0.003 GO:0007010 BP 1 cytoskeleton organization 1 O15169,P25054 240 3.12e-02 48 3 1 0.333 0.021 GO:0009799 BP 1 specification of symmetry 1 O15169 240 3.12e-02 48 3 1 0.333 0.021 GO:0009855 BP 1 determination of bilateral symmetry 1 O15169 240 3.12e-02 48 3 1 0.333 0.021 GO:0099572 CC 1 postsynaptic specialization 1 O15169 240 3.12e-02 48 3 1 0.333 0.021 GO:0014069 CC 1 postsynaptic density 1 O15169 240 3.13e-02 760 3 2 0.667 0.003 GO:0042325 BP 1 regulation of phosphorylation 1 O15169,P25054 240 3.15e-02 763 3 2 0.667 0.003 GO:0009967 BP 1 positive regulation of signal transduction 1 O15169,Q5JTC6 240 3.19e-02 49 3 1 0.333 0.020 GO:0098984 CC 1 neuron to neuron synapse 1 O15169 240 3.19e-02 49 3 1 0.333 0.020 GO:0032279 CC 1 asymmetric synapse 1 O15169 240 3.20e-02 769 3 2 0.667 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 O15169,P25054 240 3.25e-02 2707 3 3 1.000 0.001 GO:0005829 CC 1 cytosol 1 O15169,P25054,Q5JTC6 240 3.25e-02 50 3 1 0.333 0.020 GO:0033138 BP 1 positive regulation of peptidyl-serine phosphorylation 1 O15169 240 3.25e-02 50 3 1 0.333 0.020 GO:0032947 MF 1 protein complex scaffold 1 O15169 240 3.26e-02 4066 3 3 1.000 0.001 TF:M00195_0 tf 1 Factor: Oct-1; motif: NNNNATGCAAATNAN; match class: 0 1 O15169,P25054,Q5JTC6 240 3.29e-02 1175 3 2 0.667 0.002 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 O15169,Q5JTC6 240 3.32e-02 51 3 1 0.333 0.020 GO:0021953 BP 1 central nervous system neuron differentiation 1 O15169 240 3.38e-02 1404 3 2 0.667 0.001 TF:M03901_0 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 0 1 O15169,Q5JTC6 240 3.38e-02 52 3 1 0.333 0.019 GO:2001251 BP 1 negative regulation of chromosome organization 1 P25054 240 3.44e-02 798 3 2 0.667 0.003 GO:0010647 BP 1 positive regulation of cell communication 1 O15169,Q5JTC6 240 3.44e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 O15169,P25054,Q5JTC6 240 3.45e-02 53 3 1 0.333 0.019 GO:0001704 BP 1 formation of primary germ layer 1 O15169 240 3.45e-02 53 3 1 0.333 0.019 GO:0051304 BP 1 chromosome separation 1 P25054 240 3.45e-02 53 3 1 0.333 0.019 GO:0033045 BP 1 regulation of sister chromatid segregation 1 P25054 240 3.45e-02 53 3 1 0.333 0.019 GO:0043296 CC 1 apical junction complex 1 P25054 240 3.47e-02 3521 3 3 1.000 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 3.49e-02 804 3 2 0.667 0.002 GO:0023056 BP 1 positive regulation of signaling 1 O15169,Q5JTC6 240 3.49e-02 150 3 1 0.333 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 O15169 240 3.51e-02 54 3 1 0.333 0.019 GO:0055001 BP 1 muscle cell development 1 O15169 240 3.51e-02 54 3 1 0.333 0.019 GO:0051261 BP 1 protein depolymerization 1 P25054 240 3.58e-02 55 3 1 0.333 0.018 GO:0007043 BP 1 cell-cell junction assembly 1 P25054 240 3.58e-02 55 3 1 0.333 0.018 GO:0031256 CC 1 leading edge membrane 1 P25054 240 3.58e-02 3559 3 3 1.000 0.001 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 3.66e-02 1241 3 2 0.667 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 O15169,Q5JTC6 240 3.70e-02 828 3 2 0.667 0.002 GO:0098772 MF 1 molecular function regulator 1 O15169,P25054 240 3.73e-02 832 3 2 0.667 0.002 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 O15169,Q5JTC6 240 3.73e-02 1254 3 2 0.667 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 O15169,Q5JTC6 240 3.77e-02 58 3 1 0.333 0.017 GO:0031109 BP 1 microtubule polymerization or depolymerization 1 P25054 240 3.77e-02 58 3 1 0.333 0.017 GO:0018107 BP 1 peptidyl-threonine phosphorylation 1 O15169 240 3.77e-02 58 3 1 0.333 0.017 GO:0090596 BP 1 sensory organ morphogenesis 1 O15169 240 3.83e-02 1499 3 2 0.667 0.001 TF:M07043_0 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 0 1 O15169,Q5JTC6 240 3.84e-02 59 3 1 0.333 0.017 GO:1902936 MF 1 phosphatidylinositol bisphosphate binding 1 Q5JTC6 240 3.87e-02 51 3 1 0.333 0.020 REAC:75153 rea 1 Apoptotic execution phase 1 P25054 240 3.94e-02 3675 3 3 1.000 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 O15169,P25054,Q5JTC6 240 3.97e-02 61 3 1 0.333 0.016 GO:0018210 BP 1 peptidyl-threonine modification 1 O15169 240 3.97e-02 61 3 1 0.333 0.016 GO:0097194 BP 1 execution phase of apoptosis 1 P25054 240 3.98e-02 171 3 1 0.333 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 O15169 240 3.98e-02 1 3 1 0.333 1.000 HP:0030256 hp 1 Small intestinal polyposis 1 P25054 240 3.98e-02 1 3 1 0.333 1.000 HP:0100668 hp 1 Intestinal duplication 1 O15169 240 3.98e-02 1 3 1 0.333 1.000 HP:0006722 hp 1 Small intestine carcinoid 1 P25054 240 3.98e-02 1 3 1 0.333 1.000 HP:0004783 hp 1 Duodenal polyposis 1 P25054 240 3.98e-02 1 3 1 0.333 1.000 HP:0011140 hp 1 Gastrointestinal duplication 1 O15169 240 3.98e-02 1 3 1 0.333 1.000 HP:0006784 hp 1 Paranasal sinus hypoplasia 1 Q5JTC6 240 3.98e-02 1 3 1 0.333 1.000 HP:0010740 hp 1 Osteopathia striata 1 Q5JTC6 240 3.98e-02 1 3 1 0.333 1.000 HP:0011068 hp 1 Odontoma 1 P25054 240 3.98e-02 1 3 1 0.333 1.000 HP:0007649 hp 1 Congenital hypertrophy of retinal pigment epithelium 1 P25054 240 4.03e-02 62 3 1 0.333 0.016 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 P25054 240 4.03e-02 62 3 1 0.333 0.016 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 P25054 240 4.09e-02 54 3 1 0.333 0.019 REAC:4641257 rea 1 Degradation of AXIN 1 O15169 240 4.16e-02 3741 3 3 1.000 0.001 HPA:039020 hpa 1 soft tissue 1; chondrocytes 1 O15169,P25054,Q5JTC6 240 4.16e-02 179 3 1 0.333 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 P25054 240 4.21e-02 885 3 2 0.667 0.002 GO:0019220 BP 1 regulation of phosphate metabolic process 1 O15169,P25054 240 4.26e-02 1584 3 2 0.667 0.001 TF:M00284_0 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 0 1 P25054,Q5JTC6 240 4.27e-02 184 3 1 0.333 0.005 TF:M05623_0 tf 1 Factor: ZNF73; motif: NGNTGGWACAGA; match class: 0 1 P25054 240 4.29e-02 66 3 1 0.333 0.015 GO:0046330 BP 1 positive regulation of JNK cascade 1 O15169 240 4.32e-02 897 3 2 0.667 0.002 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 O15169,P25054 240 4.35e-02 67 3 1 0.333 0.015 GO:0033135 BP 1 regulation of peptidyl-serine phosphorylation 1 O15169 240 4.37e-02 2990 3 3 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 O15169,P25054,Q5JTC6 240 4.40e-02 2997 3 3 1.000 0.001 GO:0080090 BP 1 regulation of primary metabolic process 1 O15169,P25054,Q5JTC6 240 4.42e-02 68 3 1 0.333 0.015 GO:0048562 BP 1 embryonic organ morphogenesis 1 O15169 240 4.42e-02 68 3 1 0.333 0.015 GO:0051494 BP 1 negative regulation of cytoskeleton organization 1 P25054 240 4.43e-02 4503 3 3 1.000 0.001 TF:M07349_1 tf 1 Factor: AP-2gamma; motif: NNNNWGCCYNCRGSCN; match class: 1 1 O15169,P25054,Q5JTC6 240 4.44e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 O15169,P25054,Q5JTC6 240 4.48e-02 69 3 1 0.333 0.014 GO:0051983 BP 1 regulation of chromosome segregation 1 P25054 240 4.51e-02 1633 3 2 0.667 0.001 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 P25054,Q5JTC6 240 4.52e-02 3022 3 3 1.000 0.001 GO:0031323 BP 1 regulation of cellular metabolic process 1 O15169,P25054,Q5JTC6 240 4.55e-02 70 3 1 0.333 0.014 GO:0071901 BP 1 negative regulation of protein serine/threonine kinase activity 1 P25054 240 4.57e-02 3033 3 3 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 O15169,P25054,Q5JTC6 240 4.57e-02 197 3 1 0.333 0.005 TF:M01212_0 tf 1 Factor: STAT1:STAT1; motif: NTTTCCMGGAAAA; match class: 0 1 P25054 240 4.61e-02 71 3 1 0.333 0.014 GO:0007369 BP 1 gastrulation 1 O15169 240 4.64e-02 200 3 1 0.333 0.005 TF:M07403_0 tf 1 Factor: FOXP2; motif: NWGTAAACARN; match class: 0 1 P25054 240 4.66e-02 933 3 2 0.667 0.002 GO:0044430 CC 1 cytoskeletal part 1 O15169,P25054 240 4.70e-02 3063 3 3 1.000 0.001 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 O15169,P25054,Q5JTC6 240 4.71e-02 203 3 1 0.333 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 P25054 240 4.71e-02 3899 3 3 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 4.72e-02 3902 3 3 1.000 0.001 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 O15169,P25054,Q5JTC6 240 4.74e-02 73 3 1 0.333 0.014 GO:0003002 BP 1 regionalization 1 O15169 240 4.78e-02 4619 3 3 1.000 0.001 TF:M06203_1 tf 1 Factor: ZXDA; motif: NAGGGTG; match class: 1 1 O15169,P25054,Q5JTC6 240 4.78e-02 4619 3 3 1.000 0.001 TF:M06202_1 tf 1 Factor: ZXDB; motif: NAGGGTG; match class: 1 1 O15169,P25054,Q5JTC6 240 4.81e-02 74 3 1 0.333 0.014 GO:0098794 CC 1 postsynapse 1 O15169 240 4.83e-02 3931 3 3 1.000 0.001 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 O15169,P25054,Q5JTC6 240 4.86e-02 3939 3 3 1.000 0.001 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 O15169,P25054,Q5JTC6 240 5.00e-02 29 3 1 0.333 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 P25054 240 5.00e-02 59 3 2 0.667 0.034 HP:0001539 hp 1 Omphalocele 1 O15169,Q5JTC6 240 5.00e-02 77 3 1 0.333 0.013 GO:0032874 BP 1 positive regulation of stress-activated MAPK cascade 1 O15169 240 5.00e-02 7 3 1 0.333 0.143 CORUM:3008 cor 1 60S APC containing complex 1 P25054 240 5.00e-02 325 3 2 0.667 0.006 KEGG:05200 keg 1 Pathways in cancer 1 O15169,P25054 240 5.00e-02 712 3 2 0.667 0.003 REAC:597592 rea 1 Post-translational protein modification 1 O15169,P25054 241 2.97e-03 1 4 1 0.250 1.000 OMIM:616216 omi 1 THROMBOCYTOPENIA 5; THC5;;THROMBOCYTOPENIA 5 WITH INCREASED SUSCEPTIBILITY TO MALIGNANCY;;THROMBOCYTOPENIA, AUTOSOMAL DOMINANT, 5 1 P41212 241 3.80e-03 3 4 1 0.250 0.333 GO:1900041 BP 1 negative regulation of interleukin-2 secretion 1 P14373 241 4.47e-03 312 4 2 0.500 0.006 MI:hsa-miR-196a* mi 1 MI:hsa-miR-196a* 1 Q9H568,P14373 241 4.53e-03 314 4 2 0.500 0.006 MI:hsa-miR-24-1* mi 1 MI:hsa-miR-24-1* 1 Q9H568,Q93009 241 4.76e-03 322 4 2 0.500 0.006 MI:hsa-miR-24-2* mi 1 MI:hsa-miR-24-2* 1 Q9H568,Q93009 241 5.07e-03 4 4 1 0.250 0.250 GO:1900040 BP 1 regulation of interleukin-2 secretion 1 P14373 241 6.33e-03 5 4 1 0.250 0.200 GO:0070970 BP 1 interleukin-2 secretion 1 P14373 241 6.33e-03 5 4 1 0.250 0.200 GO:0010216 BP 1 maintenance of DNA methylation 1 Q93009 241 6.93e-03 390 4 2 0.500 0.005 MI:hsa-miR-569 mi 1 MI:hsa-miR-569 1 Q93009,P14373 241 7.61e-03 30 4 2 0.500 0.067 HP:0002895 hp 1 Papillary thyroid carcinoma 1 P41212,P14373 241 8.46e-03 432 4 2 0.500 0.005 MI:hsa-miR-887 mi 1 MI:hsa-miR-887 1 Q93009,P14373 241 9.04e-03 238 4 2 0.500 0.008 GO:0051090 BP 1 regulation of sequence-specific DNA binding transcription factor activity 1 Q93009,P14373 241 1.01e-02 8 4 1 0.250 0.125 GO:0002820 BP 1 negative regulation of adaptive immune response 1 P14373 241 1.01e-02 8 4 1 0.250 0.125 GO:0032703 BP 1 negative regulation of interleukin-2 production 1 P14373 241 1.02e-02 475 4 2 0.500 0.004 MI:hsa-miR-671-5p mi 1 MI:hsa-miR-671-5p 1 Q93009,P14373 241 1.08e-02 489 4 2 0.500 0.004 MI:hsa-miR-409-5p mi 1 MI:hsa-miR-409-5p 1 Q9H568,Q93009 241 1.14e-02 9 4 1 0.250 0.111 GO:0072643 BP 1 interferon-gamma secretion 1 P14373 241 1.23e-02 38 4 2 0.500 0.053 HP:0002890 hp 1 Thyroid carcinoma 1 P41212,P14373 241 1.39e-02 11 4 1 0.250 0.091 GO:0071425 BP 1 hematopoietic stem cell proliferation 1 P41212 241 1.39e-02 11 4 1 0.250 0.091 GO:0090281 BP 1 negative regulation of calcium ion import 1 P14373 241 1.48e-02 5 4 1 0.250 0.200 OMIM:313900 omi 1 Hereditary Thrombocytopenia 1 P41212 241 2.02e-02 16 4 1 0.250 0.062 GO:0032897 BP 1 negative regulation of viral transcription 1 P14373 241 2.10e-02 32 4 1 0.250 0.031 REAC:6804757 rea 1 Regulation of TP53 Degradation 1 Q93009 241 2.12e-02 50 4 2 0.500 0.040 HP:0100031 hp 1 Neoplasm of the thyroid gland 1 P41212,P14373 241 2.16e-02 33 4 1 0.250 0.030 REAC:6806003 rea 1 Regulation of TP53 Expression and Degradation 1 Q93009 241 2.21e-02 375 4 2 0.500 0.005 GO:0000122 BP 1 negative regulation of transcription from RNA polymerase II promoter 1 P41212,P14373 241 2.40e-02 19 4 1 0.250 0.053 GO:0070206 BP 1 protein trimerization 1 P14373 241 2.40e-02 19 4 1 0.250 0.053 GO:0032720 BP 1 negative regulation of tumor necrosis factor production 1 P14373 241 2.40e-02 19 4 1 0.250 0.053 GO:0032663 BP 1 regulation of interleukin-2 production 1 P14373 241 2.53e-02 20 4 1 0.250 0.050 GO:0030904 CC 1 retromer complex 1 P14373 241 2.53e-02 20 4 1 0.250 0.050 GO:1904353 BP 1 regulation of telomere capping 1 Q93009 241 2.65e-02 21 4 1 0.250 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 P14373 241 2.65e-02 21 4 1 0.250 0.048 GO:1903556 BP 1 negative regulation of tumor necrosis factor superfamily cytokine production 1 P14373 241 2.65e-02 21 4 1 0.250 0.048 GO:0034314 BP 1 Arp2/3 complex-mediated actin nucleation 1 P14373 241 2.78e-02 22 4 1 0.250 0.045 GO:0032623 BP 1 interleukin-2 production 1 P14373 241 2.91e-02 23 4 1 0.250 0.043 GO:0050710 BP 1 negative regulation of cytokine secretion 1 P14373 241 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P41212,P14373 241 3.39e-02 52 4 1 0.250 0.019 REAC:6781823 rea 1 Formation of TC-NER Pre-Incision Complex 1 Q93009 241 3.79e-02 30 4 1 0.250 0.033 GO:0045010 BP 1 actin nucleation 1 P14373 241 3.85e-02 1656 4 3 0.750 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 P41212,Q93009,P14373 241 3.90e-02 1663 4 3 0.750 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 P41212,Q93009,P14373 241 4.02e-02 1681 4 3 0.750 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 P41212,Q93009,P14373 241 4.04e-02 32 4 1 0.250 0.031 GO:0016233 BP 1 telomere capping 1 Q93009 241 4.10e-02 63 4 1 0.250 0.016 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 Q93009 241 4.12e-02 14 4 1 0.250 0.071 OMIM:231200 omi 1 Platelet-Type Bleeding Disorders 1 P41212 241 4.17e-02 64 4 1 0.250 0.016 REAC:6782135 rea 1 Dual incision in TC-NER 1 Q93009 241 4.38e-02 72 4 2 0.500 0.028 HP:0100568 hp 1 Neoplasm of the endocrine system 1 P41212,P14373 241 4.71e-02 1775 4 3 0.750 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 P41212,Q93009,P14373 241 4.79e-02 38 4 1 0.250 0.026 GO:0070534 BP 1 protein K63-linked ubiquitination 1 P14373 241 4.92e-02 39 4 1 0.250 0.026 GO:0032609 BP 1 interferon-gamma production 1 P14373 241 5.00e-02 17 4 1 0.250 0.059 OMIM:601626 omi 1 LEUKEMIA, ACUTE MYELOID; AML;;LEUKEMIA, ACUTE MYELOGENOUSLEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO, INCLUDED 1 P41212 241 5.00e-02 1 4 1 0.250 1.000 TF:M06650_1 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 1 1 P41212 241 5.00e-02 77 4 1 0.250 0.013 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 Q93009 241 5.00e-02 26 4 1 0.250 0.038 KEGG:04320 keg 1 Dorso-ventral axis formation 1 P41212 241 5.00e-02 77 4 2 0.500 0.026 HP:0011772 hp 1 Abnormality of thyroid morphology 1 P41212,P14373 241 5.00e-02 2 4 1 0.250 0.500 CORUM:5663 cor 1 TRIM27-RB1 complex 1 P14373 241 5.00e-02 570 4 2 0.500 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 Q93009,P14373 242 1.79e-03 1 4 1 0.250 1.000 GO:0097021 BP 1 lymphocyte migration into lymphoid organs 1 P07949 242 1.79e-03 1 4 1 0.250 1.000 GO:0048541 BP 1 Peyer's patch development 1 P07949 242 1.79e-03 1 4 1 0.250 1.000 GO:1901076 BP 1 positive regulation of engulfment of apoptotic cell 1 Q8IZY2 242 1.79e-03 1 4 1 0.250 1.000 GO:1900223 BP 1 positive regulation of beta-amyloid clearance 1 Q8IZY2 242 1.79e-03 1 4 1 0.250 1.000 GO:0048537 BP 1 mucosal-associated lymphoid tissue development 1 P07949 242 1.79e-03 1 4 1 0.250 1.000 GO:0061146 BP 1 Peyer's patch morphogenesis 1 P07949 242 1.79e-03 1 4 1 0.250 1.000 GO:0007497 BP 1 posterior midgut development 1 P07949 242 2.83e-03 9 4 1 0.250 0.111 TF:M06802_0 tf 1 Factor: ZFPM1; motif: NAWGGCATGGGM; match class: 0 1 Q8IZY2 242 3.25e-03 1219 4 3 0.750 0.002 TF:M07437_1 tf 1 Factor: ZBTB2; motif: TCCKCCTSR; match class: 1 1 Q8IZY2,P07949,P06865 242 3.58e-03 2 4 1 0.250 0.500 GO:1902995 BP 1 positive regulation of phospholipid efflux 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:0034188 MF 1 apolipoprotein A-I receptor activity 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:0030226 MF 1 apolipoprotein receptor activity 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:1901074 BP 1 regulation of engulfment of apoptotic cell 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:0015247 MF 1 aminophospholipid transporter activity 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:0090556 MF 1 phosphatidylserine-translocating ATPase activity 1 Q8IZY2 242 3.58e-03 2 4 1 0.250 0.500 GO:1902994 BP 1 regulation of phospholipid efflux 1 Q8IZY2 242 4.39e-03 14 4 1 0.250 0.071 TF:M06568_0 tf 1 Factor: ZNF501; motif: NGGTTTTAAGGA; match class: 0 1 Q8IZY2 242 4.82e-03 1395 4 3 0.750 0.002 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q8IZY2,P07949,P06865 242 5.17e-03 336 4 2 0.500 0.006 MI:hsa-miR-211 mi 1 MI:hsa-miR-211 1 P07949,P06865 242 5.29e-03 3433 4 4 1.000 0.001 TF:M00915_0 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 0 1 Q8IZY2,P07949,P06865,P0CG31 242 5.37e-03 3 4 1 0.250 0.333 GO:0072300 BP 1 positive regulation of metanephric glomerulus development 1 P07949 242 5.37e-03 3 4 1 0.250 0.333 GO:0072298 BP 1 regulation of metanephric glomerulus development 1 P07949 242 5.37e-03 3 4 1 0.250 0.333 GO:0043652 BP 1 engulfment of apoptotic cell 1 Q8IZY2 242 5.37e-03 3 4 1 0.250 0.333 GO:0007494 BP 1 midgut development 1 P07949 242 5.37e-03 3 4 1 0.250 0.333 GO:0004563 MF 1 beta-N-acetylhexosaminidase activity 1 P06865 242 5.69e-03 1 4 1 0.250 1.000 HP:0008208 hp 1 Parathyroid hyperplasia 1 P07949 242 5.69e-03 1 4 1 0.250 1.000 HP:0003528 hp 1 Elevated calcitonin 1 P07949 242 5.69e-03 1 4 1 0.250 1.000 HP:0003639 hp 1 Elevated urinary epinephrine 1 P07949 242 5.96e-03 19 4 1 0.250 0.053 TF:M00460_0 tf 1 Factor: STAT5A; motif: TTCCNRGAANNNNNNTTCCNNGRR; match class: 0 1 P0CG31 242 6.27e-03 20 4 1 0.250 0.050 TF:M07358_1 tf 1 Factor: HSF2; motif: NGGAATNTTCTNGNRN; match class: 1 1 P0CG31 242 6.50e-03 429 4 2 0.500 0.005 TF:M00797_0 tf 1 Factor: HIF1; motif: GNNKACGTGCGGNN; match class: 0 1 Q8IZY2,P07949 242 6.58e-03 380 4 2 0.500 0.005 MI:hsa-miR-204 mi 1 MI:hsa-miR-204 1 P07949,P06865 242 7.16e-03 4 4 1 0.250 0.250 GO:0038027 BP 1 apolipoprotein A-I-mediated signaling pathway 1 Q8IZY2 242 7.16e-03 4 4 1 0.250 0.250 GO:0090554 MF 1 phosphatidylcholine-translocating ATPase activity 1 Q8IZY2 242 7.16e-03 4 4 1 0.250 0.250 GO:2001241 BP 1 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 P07949 242 7.16e-03 4 4 1 0.250 0.250 GO:0042985 BP 1 negative regulation of amyloid precursor protein biosynthetic process 1 Q8IZY2 242 7.16e-03 4 4 1 0.250 0.250 GO:1902430 BP 1 negative regulation of beta-amyloid formation 1 Q8IZY2 242 8.36e-03 1 4 1 0.250 1.000 OMIM:171400 omi 1 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A;;PHEOCHROMOCYTOMA AND AMYLOID-PRODUCING MEDULLARY THYROID CARCINOMA;;PTC SYNDROME;;SIPPLE SYNDROMETHYROID CARCINOMA, FAMILIAL MEDULLARY, INCLUDED 1 P07949 242 8.36e-03 1 4 1 0.250 1.000 OMIM:162300 omi 1 MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIB; MEN2B;;MEN IIB;;NEUROMATA, MUCOSAL, WITH ENDOCRINE TUMORS;;WAGENMANN-FROBOESE SYNDROME;;MULTIPLE ENDOCRINE NEOPLASIA, TYPE III, FORMERLY; MEN3, FORMERLYMUCOSAL NEUROMA SYNDROME, INCLUDED 1 P07949 242 8.36e-03 1 4 1 0.250 1.000 OMIM:272800 omi 1 TAY-SACHS DISEASE; TSD;;GM2-GANGLIOSIDOSIS, TYPE I;;B VARIANT GM2-GANGLIOSIDOSIS;;HEXOSAMINIDASE A DEFICIENCY;;HEXA DEFICIENCYTAY-SACHS DISEASE, JUVENILE, INCLUDED;;HEXOSAMINIDASE A DEFICIENCY, ADULT TYPE, INCLUDED;;GM2-GANGLIOSIDOSIS, ADULT CHRONIC TYPE, INCLUDED;;GM2-GANGLIOSIDOSIS, VARIANT B1, INCLUDED;;TAY-SACHS DISEASE, VARIANT B1, INCLUDED;;TAY-SACHS DISEASE, PSEUDO-AB VARIANT, INCLUDED 1 P06865 242 8.94e-03 5 4 1 0.250 0.200 GO:0042984 BP 1 regulation of amyloid precursor protein biosynthetic process 1 Q8IZY2 242 8.94e-03 5 4 1 0.250 0.200 GO:2000427 BP 1 positive regulation of apoptotic cell clearance 1 Q8IZY2 242 8.94e-03 5 4 1 0.250 0.200 GO:0048265 BP 1 response to pain 1 P07949 242 8.94e-03 5 4 1 0.250 0.200 GO:0090193 BP 1 positive regulation of glomerulus development 1 P07949 242 8.94e-03 5 4 1 0.250 0.200 GO:0042983 BP 1 amyloid precursor protein biosynthetic process 1 Q8IZY2 242 8.94e-03 5 4 1 0.250 0.200 GO:1905155 BP 1 positive regulation of membrane invagination 1 Q8IZY2 242 8.94e-03 5 4 1 0.250 0.200 GO:0060100 BP 1 positive regulation of phagocytosis, engulfment 1 Q8IZY2 242 8.94e-03 5 4 1 0.250 0.200 GO:0034380 BP 1 high-density lipoprotein particle assembly 1 Q8IZY2 242 9.08e-03 448 4 2 0.500 0.004 MI:hsa-miR-564 mi 1 MI:hsa-miR-564 1 Q8IZY2,P06865 242 9.28e-03 453 4 2 0.500 0.004 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 Q8IZY2,P06865 242 1.01e-02 1798 4 3 0.750 0.002 TF:M00340_1 tf 1 Factor: c-Ets; motif: KRCAGGAARTRNKT; match class: 1 1 Q8IZY2,P07949,P0CG31 242 1.03e-02 33 4 1 0.250 0.030 TF:M05798_0 tf 1 Factor: ZNF517; motif: NGGGAAGGCGGC; match class: 0 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:1905153 BP 1 regulation of membrane invagination 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:2001140 BP 1 positive regulation of phospholipid transport 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:0072224 BP 1 metanephric glomerulus development 1 P07949 242 1.07e-02 6 4 1 0.250 0.167 GO:2001138 BP 1 regulation of phospholipid transport 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:1902992 BP 1 negative regulation of amyloid precursor protein catabolic process 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:0060099 BP 1 regulation of phagocytosis, engulfment 1 Q8IZY2 242 1.07e-02 6 4 1 0.250 0.167 GO:1900221 BP 1 regulation of beta-amyloid clearance 1 Q8IZY2 242 1.13e-02 36 4 1 0.250 0.028 TF:M05565_0 tf 1 Factor: ZNF772; motif: KGGTATGCCAKA; match class: 0 1 P0CG31 242 1.14e-02 2 4 1 0.250 0.500 HP:0005994 hp 1 Nodular goiter 1 P07949 242 1.14e-02 2 4 1 0.250 0.500 HP:0003495 hp 1 GM2-ganglioside accumulation 1 P06865 242 1.14e-02 2 4 1 0.250 0.500 HP:0002865 hp 1 Medullary thyroid carcinoma 1 P07949 242 1.16e-02 37 4 1 0.250 0.027 TF:M06703_0 tf 1 Factor: ZNF160; motif: NGGKAAAAATGA; match class: 0 1 P06865 242 1.16e-02 37 4 1 0.250 0.027 TF:M05742_0 tf 1 Factor: ZNF57; motif: NSRAMGGGCAGG; match class: 0 1 P06865 242 1.25e-02 7 4 1 0.250 0.143 GO:2000425 BP 1 regulation of apoptotic cell clearance 1 Q8IZY2 242 1.25e-02 7 4 1 0.250 0.143 GO:0001891 CC 1 phagocytic cup 1 Q8IZY2 242 1.25e-02 7 4 1 0.250 0.143 GO:0043190 CC 1 ATP-binding cassette (ABC) transporter complex 1 Q8IZY2 242 1.25e-02 7 4 1 0.250 0.143 GO:0097242 BP 1 beta-amyloid clearance 1 Q8IZY2 242 1.25e-02 7 4 1 0.250 0.143 GO:0008525 MF 1 phosphatidylcholine transporter activity 1 Q8IZY2 242 1.25e-02 7 4 1 0.250 0.143 GO:0090192 BP 1 regulation of glomerulus development 1 P07949 242 1.36e-02 246 4 2 0.500 0.008 GO:0009100 BP 1 glycoprotein metabolic process 1 Q8IZY2,P06865 242 1.41e-02 45 4 1 0.250 0.022 TF:M05942_0 tf 1 Factor: ZNF700; motif: NTGTCAAAATCN; match class: 0 1 P0CG31 242 1.43e-02 8 4 1 0.250 0.125 GO:0010561 BP 1 negative regulation of glycoprotein biosynthetic process 1 Q8IZY2 242 1.43e-02 8 4 1 0.250 0.125 GO:1902003 BP 1 regulation of beta-amyloid formation 1 Q8IZY2 242 1.43e-02 8 4 1 0.250 0.125 GO:0034205 BP 1 beta-amyloid formation 1 Q8IZY2 242 1.57e-02 2099 4 3 0.750 0.001 TF:M07376_0 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 0 1 Q8IZY2,P06865,P0CG31 242 1.59e-02 51 4 1 0.250 0.020 TF:M06423_0 tf 1 Factor: ZNF571; motif: NGKGWGGGCTGC; match class: 0 1 P07949 242 1.60e-02 2111 4 3 0.750 0.001 TF:M01009_0 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 0 1 Q8IZY2,P07949,P0CG31 242 1.61e-02 9 4 1 0.250 0.111 GO:0015929 MF 1 hexosaminidase activity 1 P06865 242 1.61e-02 9 4 1 0.250 0.111 GO:0072216 BP 1 positive regulation of metanephros development 1 P07949 242 1.67e-02 2 4 1 0.250 0.500 OMIM:155240 omi 1 THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC;;FMTC;;MTC1 1 P07949 242 1.68e-02 9 4 1 0.250 0.111 KEGG:00603 keg 1 Glycosphingolipid biosynthesis - globo and isoglobo series 1 P06865 242 1.71e-02 3 4 1 0.250 0.333 HP:0006461 hp 1 Proximal femoral epiphysiolysis 1 P07949 242 1.71e-02 3 4 1 0.250 0.333 HP:0002361 hp 1 Psychomotor deterioration 1 P06865 242 1.74e-02 712 4 2 0.500 0.003 TF:M04263_0 tf 1 Factor: FOXO4; motif: TTTCCCCACACG; match class: 0 1 P07949,P0CG31 242 1.75e-02 56 4 1 0.250 0.018 TF:M02058_1 tf 1 Factor: SAP1A; motif: NCCGGAARYN; match class: 1 1 P06865 242 1.75e-02 56 4 1 0.250 0.018 TF:M03990_1 tf 1 Factor: GABPA; motif: ACCGGAAGTN; match class: 1 1 P06865 242 1.79e-02 10 4 1 0.250 0.100 GO:0033555 BP 1 multicellular organismal response to stress 1 P07949 242 1.79e-02 10 4 1 0.250 0.100 GO:0033700 BP 1 phospholipid efflux 1 Q8IZY2 242 1.79e-02 10 4 1 0.250 0.100 GO:0042340 BP 1 keratan sulfate catabolic process 1 P06865 242 1.79e-02 10 4 1 0.250 0.100 GO:1903019 BP 1 negative regulation of glycoprotein metabolic process 1 Q8IZY2 242 1.79e-02 10 4 1 0.250 0.100 GO:0072215 BP 1 regulation of metanephros development 1 P07949 242 1.79e-02 10 4 1 0.250 0.100 GO:0030207 BP 1 chondroitin sulfate catabolic process 1 P06865 242 1.79e-02 10 4 1 0.250 0.100 GO:0033630 BP 1 positive regulation of cell adhesion mediated by integrin 1 P07949 242 1.79e-02 10 4 1 0.250 0.100 GO:1902991 BP 1 regulation of amyloid precursor protein catabolic process 1 Q8IZY2 242 1.97e-02 63 4 1 0.250 0.016 TF:M06201_0 tf 1 Factor: ZNF93; motif: NTGGGAAGAAKA; match class: 0 1 Q8IZY2 242 1.97e-02 11 4 1 0.250 0.091 GO:0030214 BP 1 hyaluronan catabolic process 1 P06865 242 1.97e-02 11 4 1 0.250 0.091 GO:0007158 BP 1 neuron cell-cell adhesion 1 P07949 242 1.97e-02 2869 4 4 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q8IZY2,P07949,P06865,P0CG31 242 2.02e-02 4802 4 4 1.000 0.001 TF:M07437_0 tf 1 Factor: ZBTB2; motif: TCCKCCTSR; match class: 0 1 Q8IZY2,P07949,P06865,P0CG31 242 2.05e-02 11 4 1 0.250 0.091 KEGG:00604 keg 1 Glycosphingolipid biosynthesis - ganglio series 1 P06865 242 2.14e-02 793 4 2 0.500 0.003 TF:M00072_1 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 1 1 Q8IZY2,P0CG31 242 2.14e-02 12 4 1 0.250 0.083 GO:0042582 CC 1 azurophil granule 1 P06865 242 2.14e-02 12 4 1 0.250 0.083 GO:0005766 CC 1 primary lysosome 1 P06865 242 2.14e-02 12 4 1 0.250 0.083 GO:0072210 BP 1 metanephric nephron development 1 P07949 242 2.14e-02 12 4 1 0.250 0.083 GO:0010875 BP 1 positive regulation of cholesterol efflux 1 Q8IZY2 242 2.21e-02 71 4 1 0.250 0.014 TF:M00977_1 tf 1 Factor: EBF; motif: KTCCCYWGRGA; match class: 1 1 Q8IZY2 242 2.31e-02 74 4 1 0.250 0.014 TF:M02059_1 tf 1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 1 P06865 242 2.32e-02 13 4 1 0.250 0.077 GO:1903793 BP 1 positive regulation of anion transport 1 Q8IZY2 242 2.32e-02 13 4 1 0.250 0.077 GO:0050435 BP 1 beta-amyloid metabolic process 1 Q8IZY2 242 2.32e-02 13 4 1 0.250 0.077 GO:0034377 BP 1 plasma lipoprotein particle assembly 1 Q8IZY2 242 2.42e-02 13 4 1 0.250 0.077 KEGG:00531 keg 1 Glycosaminoglycan degradation 1 P06865 242 2.50e-02 14 4 1 0.250 0.071 GO:0018149 BP 1 peptide cross-linking 1 Q8IZY2 242 2.50e-02 14 4 1 0.250 0.071 GO:0032376 BP 1 positive regulation of cholesterol transport 1 Q8IZY2 242 2.50e-02 14 4 1 0.250 0.071 GO:0032373 BP 1 positive regulation of sterol transport 1 Q8IZY2 242 2.50e-02 14 4 1 0.250 0.071 GO:0010874 BP 1 regulation of cholesterol efflux 1 Q8IZY2 242 2.50e-02 3 4 1 0.250 0.333 OMIM:209880 omi 1 CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL; CCHS;;AUTONOMIC CONTROL, CONGENITAL FAILURE OF;;ONDINE CURSE, CONGENITALONDINE-HIRSCHSPRUNG DISEASE, INCLUDED; OHD, INCLUDED;;CCHS WITH HIRSCHSPRUNG DISEASE, INCLUDED;;HADDAD SYNDROME, INCLUDED 1 P07949 242 2.50e-02 3 4 1 0.250 0.333 OMIM:131100 omi 1 Multiple Endocrine Neoplasia 1 P07949 242 2.50e-02 3 4 1 0.250 0.333 OMIM:191830 omi 1 Renal Hypodysplasia/Aplasia 1 P07949 242 2.57e-02 2497 4 3 0.750 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q8IZY2,P06865,P0CG31 242 2.68e-02 15 4 1 0.250 0.067 GO:0065005 BP 1 protein-lipid complex assembly 1 Q8IZY2 242 2.74e-02 88 4 1 0.250 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 P06865 242 2.84e-02 5 4 1 0.250 0.200 HP:0004345 hp 1 Abnormality of ganglioside metabolism 1 P06865 242 2.84e-02 5 4 1 0.250 0.200 HP:0007110 hp 1 Central hypoventilation 1 P07949 242 2.84e-02 5 4 1 0.250 0.200 HP:0100282 hp 1 Acute colitis 1 P07949 242 2.84e-02 5 4 1 0.250 0.200 HP:0004387 hp 1 Enterocolitis 1 P07949 242 2.86e-02 16 4 1 0.250 0.062 GO:0045332 BP 1 phospholipid translocation 1 Q8IZY2 242 2.86e-02 16 4 1 0.250 0.062 GO:1904949 CC 1 ATPase complex 1 Q8IZY2 242 2.86e-02 16 4 1 0.250 0.062 GO:0098533 CC 1 ATPase dependent transmembrane transport complex 1 Q8IZY2 242 2.89e-02 93 4 1 0.250 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 P06865 242 2.92e-02 94 4 1 0.250 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 P06865 242 2.98e-02 96 4 1 0.250 0.010 TF:M06567_0 tf 1 Factor: ZNF707; motif: NASTCMTAAAGA; match class: 0 1 P06865 242 3.04e-02 17 4 1 0.250 0.059 GO:0042987 BP 1 amyloid precursor protein catabolic process 1 Q8IZY2 242 3.04e-02 17 4 1 0.250 0.059 GO:0030212 BP 1 hyaluronan metabolic process 1 P06865 242 3.04e-02 17 4 1 0.250 0.059 GO:0090184 BP 1 positive regulation of kidney development 1 P07949 242 3.04e-02 17 4 1 0.250 0.059 GO:0034204 BP 1 lipid translocation 1 Q8IZY2 242 3.04e-02 17 4 1 0.250 0.059 GO:0006911 BP 1 phagocytosis, engulfment 1 Q8IZY2 242 3.08e-02 99 4 1 0.250 0.010 TF:M04188_0 tf 1 Factor: SREBF2; motif: ATCACGTGAY; match class: 0 1 P06865 242 3.08e-02 99 4 1 0.250 0.010 TF:M04162_0 tf 1 Factor: BHLHE40; motif: NKCACGTGMC; match class: 0 1 P06865 242 3.11e-02 100 4 1 0.250 0.010 TF:M06541_0 tf 1 Factor: ZNF502; motif: NGKTAGGRAATC; match class: 0 1 P0CG31 242 3.16e-02 17 4 1 0.250 0.059 KEGG:00511 keg 1 Other glycan degradation 1 P06865 242 3.19e-02 5379 4 4 1.000 0.001 TF:M02071_1 tf 1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 1 Q8IZY2,P07949,P06865,P0CG31 242 3.39e-02 19 4 1 0.250 0.053 GO:0004012 MF 1 phospholipid-translocating ATPase activity 1 Q8IZY2 242 3.41e-02 6 4 1 0.250 0.167 HP:0011334 hp 1 Facial shape deformation 1 P07949 242 3.41e-02 6 4 1 0.250 0.167 HP:0002009 hp 1 Potter facies 1 P07949 242 3.41e-02 110 4 1 0.250 0.009 TF:M04058_0 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 0 1 Q8IZY2 242 3.45e-02 1019 4 2 0.500 0.002 TF:M03979_0 tf 1 Factor: ETV1; motif: ACCGGAAGTN; match class: 0 1 Q8IZY2,P06865 242 3.45e-02 5486 4 4 1.000 0.001 TF:M02056_0 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 0 1 Q8IZY2,P07949,P06865,P0CG31 242 3.57e-02 115 4 1 0.250 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 P06865 242 3.57e-02 20 4 1 0.250 0.050 GO:0071827 BP 1 plasma lipoprotein particle organization 1 Q8IZY2 242 3.57e-02 20 4 1 0.250 0.050 GO:2001239 BP 1 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 P07949 242 3.57e-02 20 4 1 0.250 0.050 GO:0032370 BP 1 positive regulation of lipid transport 1 Q8IZY2 242 3.60e-02 116 4 1 0.250 0.009 TF:M05880_0 tf 1 Factor: ZNF676; motif: NGGGTAGGGTGA; match class: 0 1 P06865 242 3.65e-02 1050 4 2 0.500 0.002 TF:M03878_1 tf 1 Factor: MIBP1; motif: WNWCCCCAGCTR; match class: 1 1 Q8IZY2,P07949 242 3.75e-02 21 4 1 0.250 0.048 GO:0010559 BP 1 regulation of glycoprotein biosynthetic process 1 Q8IZY2 242 3.78e-02 122 4 1 0.250 0.008 TF:M04178_0 tf 1 Factor: MLXIPL; motif: RTCACGTGAT; match class: 0 1 P06865 242 3.93e-02 22 4 1 0.250 0.045 GO:0071825 BP 1 protein-lipid complex subunit organization 1 Q8IZY2 242 3.93e-02 22 4 1 0.250 0.045 GO:0043277 BP 1 apoptotic cell clearance 1 Q8IZY2 242 3.93e-02 22 4 1 0.250 0.045 GO:0090183 BP 1 regulation of kidney development 1 P07949 242 3.93e-02 22 4 1 0.250 0.045 GO:2001238 BP 1 positive regulation of extrinsic apoptotic signaling pathway 1 P07949 242 3.93e-02 1093 4 2 0.500 0.002 TF:M06117_0 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 0 1 P07949,P06865 242 3.97e-02 7 4 1 0.250 0.143 HP:0030074 hp 1 Chemodectoma 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0012099 hp 1 Abnormality of circulating catecholamine level 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0010497 hp 1 Sirenomelia 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0006737 hp 1 Extraadrenal pheochromocytoma 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0100642 hp 1 Neoplasm of the adrenal medulla 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0003334 hp 1 Elevated circulating catecholamine level 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0001686 hp 1 Loss of voice 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0006715 hp 1 Glomus tympanicum paraganglioma 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0006748 hp 1 Adrenal pheochromocytoma 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0003001 hp 1 Glomus jugular tumor 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0002864 hp 1 Paraganglioma of head and neck 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0010729 hp 1 Cherry red spot of the macula 1 P06865 242 3.97e-02 7 4 1 0.250 0.143 HP:0002331 hp 1 Recurrent paroxysmal headache 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0000740 hp 1 Episodic paroxysmal anxiety 1 P07949 242 3.97e-02 7 4 1 0.250 0.143 HP:0002886 hp 1 Vagal paraganglioma 1 P07949 242 4.10e-02 23 4 1 0.250 0.043 GO:0033628 BP 1 regulation of cell adhesion mediated by integrin 1 P07949 242 4.12e-02 133 4 1 0.250 0.008 TF:M06033_0 tf 1 Factor: ZNF878; motif: NGGTTTTANTCM; match class: 0 1 P06865 242 4.17e-02 10 4 1 0.250 0.100 REAC:2160916 rea 1 Hyaluronan uptake and degradation 1 P06865 242 4.17e-02 10 4 1 0.250 0.100 REAC:2022857 rea 1 Keratan sulfate degradation 1 P06865 242 4.17e-02 5 4 1 0.250 0.200 OMIM:142623 omi 1 Hirschsprung Disease 1 P07949 242 4.18e-02 135 4 1 0.250 0.007 TF:M01224_1 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 1 P07949 242 4.21e-02 136 4 1 0.250 0.007 TF:M05522_0 tf 1 Factor: ZNF341; motif: NTGGGGGGGGGG; match class: 0 1 P06865 242 4.28e-02 24 4 1 0.250 0.042 GO:0097035 BP 1 regulation of membrane lipid distribution 1 Q8IZY2 242 4.28e-02 24 4 1 0.250 0.042 GO:0042339 BP 1 keratan sulfate metabolic process 1 P06865 242 4.28e-02 24 4 1 0.250 0.042 GO:0042982 BP 1 amyloid precursor protein metabolic process 1 Q8IZY2 242 4.39e-02 1159 4 2 0.500 0.002 TF:M01588_0 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 0 1 Q8IZY2,P07949 242 4.45e-02 3035 4 3 0.750 0.001 TF:M02100_0 tf 1 Factor: MyoD; motif: CASCTGNCN; match class: 0 1 Q8IZY2,P07949,P06865 242 4.46e-02 25 4 1 0.250 0.040 GO:0030204 BP 1 chondroitin sulfate metabolic process 1 P06865 242 4.46e-02 25 4 1 0.250 0.040 GO:0050766 BP 1 positive regulation of phagocytosis 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:0032371 BP 1 regulation of sterol transport 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:0032374 BP 1 regulation of cholesterol transport 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:0099024 BP 1 plasma membrane invagination 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:1903018 BP 1 regulation of glycoprotein metabolic process 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:0007613 BP 1 memory 1 Q8IZY2 242 4.46e-02 25 4 1 0.250 0.040 GO:0072676 BP 1 lymphocyte migration 1 P07949 242 4.50e-02 5864 4 4 1.000 0.001 TF:M02070_1 tf 1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 1 Q8IZY2,P07949,P06865,P0CG31 242 4.54e-02 8 4 1 0.250 0.125 HP:0003005 hp 1 Ganglioneuroma 1 P07949 242 4.54e-02 8 4 1 0.250 0.125 HP:0002668 hp 1 Paraganglioma 1 P07949 242 4.54e-02 8 4 1 0.250 0.125 HP:0010969 hp 1 Abnormality of glycolipid metabolism 1 P06865 242 4.54e-02 8 4 1 0.250 0.125 HP:0030450 hp 1 Neuroplasm of the autonomic nervous system 1 P07949 242 4.54e-02 8 4 1 0.250 0.125 HP:0002897 hp 1 Parathyroid adenoma 1 P07949 242 4.54e-02 8 4 1 0.250 0.125 HP:0006747 hp 1 Ganglioneuroblastoma 1 P07949 242 4.54e-02 8 4 1 0.250 0.125 HP:0004343 hp 1 Abnormality of glycosphingolipid metabolism 1 P06865 242 4.54e-02 8 4 1 0.250 0.125 HP:0010968 hp 1 Abnormality of liposaccharide metabolism 1 P06865 242 4.58e-02 11 4 1 0.250 0.091 REAC:2024101 rea 1 CS/DS degradation 1 P06865 242 4.64e-02 26 4 1 0.250 0.038 GO:0001656 BP 1 metanephros development 1 P07949 242 4.72e-02 153 4 1 0.250 0.007 TF:M05731_0 tf 1 Factor: ZNF660; motif: NGGGGGGAACSM; match class: 0 1 P07949 242 4.72e-02 3569 4 4 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 Q8IZY2,P07949,P06865,P0CG31 242 4.78e-02 466 4 2 0.500 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q8IZY2,P06865 242 4.82e-02 27 4 1 0.250 0.037 GO:0050654 BP 1 chondroitin sulfate proteoglycan metabolic process 1 P06865 242 4.99e-02 28 4 1 0.250 0.036 GO:0071300 BP 1 cellular response to retinoic acid 1 P07949 242 5.00e-02 12 4 1 0.250 0.083 REAC:2142845 rea 1 Hyaluronan metabolism 1 P06865 242 5.00e-02 2 4 1 0.250 0.500 CORUM:903 cor 1 RET-Rai complex 1 P07949 242 5.00e-02 6 4 1 0.250 0.167 OMIM:171300 omi 1 PHEOCHROMOCYTOMAPHEOCHROMOCYTOMA, SUSCEPTIBILITY TO 1 P07949 242 5.00e-02 3620 4 4 1.000 0.001 GO:0009058 BP 1 biosynthetic process 1 Q8IZY2,P07949,P06865,P0CG31 242 5.00e-02 130 4 2 0.500 0.015 HP:0008046 hp 1 Abnormality of the retinal vasculature 1 P07949,P06865 243 1.08e-07 18 4 3 0.750 0.167 GO:0030992 CC 1 intraciliary transport particle B 1 Q96AJ1,Q9NWB7,Q8TDR0 243 3.88e-07 27 4 3 0.750 0.111 GO:0030990 CC 1 intraciliary transport particle 1 Q96AJ1,Q9NWB7,Q8TDR0 243 5.79e-07 39 4 3 0.750 0.077 REAC:5620924 rea 1 Intraflagellar transport 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.41e-06 41 4 3 0.750 0.073 GO:0097542 CC 1 ciliary tip 1 Q96AJ1,Q9NWB7,Q8TDR0 243 5.30e-05 173 4 3 0.750 0.017 REAC:5617833 rea 1 Assembly of the primary cilium 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.61e-04 21 4 2 0.500 0.095 GO:0099118 BP 1 microtubule-based protein transport 1 Q9NWB7,Q8TDR0 243 1.61e-04 21 4 2 0.500 0.095 GO:0098840 BP 1 protein transport along microtubule 1 Q9NWB7,Q8TDR0 243 1.61e-04 21 4 2 0.500 0.095 GO:0042073 BP 1 intraciliary transport 1 Q9NWB7,Q8TDR0 243 1.88e-04 206 4 3 0.750 0.015 GO:0060271 BP 1 cilium assembly 1 Q96AJ1,Q9NWB7,Q8TDR0 243 2.29e-04 220 4 3 0.750 0.014 GO:0044441 CC 1 ciliary part 1 Q96AJ1,Q9NWB7,Q8TDR0 243 3.15e-04 314 4 3 0.750 0.010 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 Q96AJ1,Q9NWB7,Q8TDR0 243 4.10e-04 267 4 3 0.750 0.011 GO:0005929 CC 1 cilium 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.47e-03 409 4 3 0.750 0.007 GO:0005813 CC 1 centrosome 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.47e-03 409 4 3 0.750 0.007 GO:0044463 CC 1 cell projection part 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.49e-03 63 4 2 0.500 0.032 GO:0031503 BP 1 protein complex localization 1 Q9NWB7,Q8TDR0 243 2.12e-03 2318 4 4 1.000 0.002 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 2.27e-03 474 4 3 0.750 0.006 GO:0005815 CC 1 microtubule organizing center 1 Q96AJ1,Q9NWB7,Q8TDR0 243 2.40e-03 80 4 2 0.500 0.025 GO:0010970 BP 1 transport along microtubule 1 Q9NWB7,Q8TDR0 243 2.40e-03 80 4 2 0.500 0.025 GO:0099111 BP 1 microtubule-based transport 1 Q9NWB7,Q8TDR0 243 3.75e-03 100 4 2 0.500 0.020 GO:0030705 BP 1 cytoskeleton-dependent intracellular transport 1 Q9NWB7,Q8TDR0 243 6.28e-03 1 4 1 0.250 1.000 OMIM:616629 omi 1 SENIOR-LOKEN SYNDROME 9; SLSN9 1 Q8TDR0 243 6.28e-03 1 4 1 0.250 1.000 OMIM:611868 omi 1 PROSTATE CANCER, HEREDITARY, 12; HPC12 1 Q8NDI1 243 7.55e-03 142 4 2 0.500 0.014 GO:0044782 BP 1 cilium organization 1 Q9NWB7,Q8TDR0 243 8.11e-03 728 4 3 0.750 0.004 GO:0042995 CC 1 cell projection 1 Q96AJ1,Q9NWB7,Q8TDR0 243 9.54e-03 769 4 3 0.750 0.004 GO:0015630 CC 1 microtubule cytoskeleton 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.08e-02 490 4 2 0.500 0.004 MI:hsa-miR-34b mi 1 MI:hsa-miR-34b 1 Q96AJ1,Q8NDI1 243 1.09e-02 171 4 2 0.500 0.012 GO:0007018 BP 1 microtubule-based movement 1 Q9NWB7,Q8TDR0 243 1.30e-02 1666 4 3 0.750 0.002 HPA:040040_02 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Medium] 1 Q96AJ1,Q9NWB7,Q8NDI1 243 1.63e-02 11 4 1 0.250 0.091 HP:0008802 hp 1 Hypoplasia of the femoral head 1 Q8TDR0 243 1.69e-02 933 4 3 0.750 0.003 GO:0044430 CC 1 cytoskeletal part 1 Q96AJ1,Q9NWB7,Q8TDR0 243 1.71e-02 3902 4 4 1.000 0.001 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 1.72e-02 1838 4 3 0.750 0.002 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 Q9NWB7,Q8NDI1,Q8TDR0 243 1.76e-02 3931 4 4 1.000 0.001 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 1.76e-02 608 4 2 0.500 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q9NWB7,Q8NDI1 243 1.78e-02 12 4 1 0.250 0.083 HP:0001583 hp 1 Rotary nystagmus 1 Q8TDR0 243 1.94e-02 639 4 2 0.500 0.003 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 Q9NWB7,Q8NDI1 243 2.36e-02 16 4 1 0.250 0.062 HP:0001407 hp 1 Hepatic cysts 1 Q8TDR0 243 2.39e-02 713 4 2 0.500 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q9NWB7,Q8NDI1 243 2.50e-02 4293 4 4 1.000 0.001 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 2.51e-02 17 4 1 0.250 0.059 HP:0030082 hp 1 Abnormal drinking behavior 1 Q8TDR0 243 2.51e-02 17 4 1 0.250 0.059 HP:0001959 hp 1 Polydipsia 1 Q8TDR0 243 2.65e-02 18 4 1 0.250 0.056 HP:0000547 hp 1 Tapetoretinal degeneration 1 Q8TDR0 243 2.76e-02 4399 4 4 1.000 0.001 HPA:021020_02 hpa 1 liver; hepatocytes[Uncertain,Medium] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 2.78e-02 4407 4 4 1.000 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 2.80e-02 19 4 1 0.250 0.053 HP:0000108 hp 1 Renal corticomedullary cysts 1 Q8TDR0 243 2.80e-02 19 4 1 0.250 0.053 HP:0000103 hp 1 Polyuria 1 Q8TDR0 243 2.99e-02 4491 4 4 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 3.22e-02 4574 4 4 1.000 0.001 HPA:021010_01 hpa 1 liver; bile duct cells[Uncertain,Low] 1 Q96AJ1,Q9NWB7,Q8NDI1,Q8TDR0 243 3.47e-02 867 4 2 0.500 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q96AJ1,Q8NDI1 243 3.50e-02 872 4 2 0.500 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 Q9NWB7,Q8TDR0 243 3.53e-02 12 4 1 0.250 0.083 GO:0050687 BP 1 negative regulation of defense response to virus 1 Q8TDR0 243 3.56e-02 1204 4 3 0.750 0.002 GO:0005856 CC 1 cytoskeleton 1 Q96AJ1,Q9NWB7,Q8TDR0 243 3.67e-02 25 4 1 0.250 0.040 HP:0012590 hp 1 Abnormal urine output 1 Q8TDR0 243 3.83e-02 914 4 2 0.500 0.002 HPA:040020_10 hpa 1 soft tissue 2; chondrocytes[Supportive,Not detected] 1 Q9NWB7,Q8NDI1 243 3.90e-02 2454 4 3 0.750 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q96AJ1,Q9NWB7,Q8TDR0 243 3.96e-02 930 4 2 0.500 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q9NWB7,Q8NDI1 243 3.96e-02 27 4 1 0.250 0.037 HP:0011036 hp 1 Abnormality of renal excretion 1 Q8TDR0 243 4.11e-02 28 4 1 0.250 0.036 HP:0009108 hp 1 Aplasia/Hypoplasia involving the femoral head and neck 1 Q8TDR0 243 4.23e-02 2527 4 3 0.750 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 Q96AJ1,Q9NWB7,Q8TDR0 243 4.68e-02 32 4 1 0.250 0.031 HP:0005613 hp 1 Aplasia/hypoplasia of the femur 1 Q8TDR0 243 4.97e-02 34 4 1 0.250 0.029 HP:0001737 hp 1 Pancreatic cysts 1 Q8TDR0 243 5.00e-02 17 4 1 0.250 0.059 GO:0097546 CC 1 ciliary base 1 Q8TDR0 243 5.00e-02 481 4 3 0.750 0.006 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 Q96AJ1,Q9NWB7,Q8NDI1 243 5.00e-02 8 4 1 0.250 0.125 OMIM:266900 omi 1 Senior-Loken Syndrome 1 Q8TDR0 244 2.24e-03 530 2 2 1.000 0.004 MI:hsa-let-7f-2* mi 1 MI:hsa-let-7f-2* 1 P07864,O00244 244 3.34e-03 2 2 1 0.500 0.500 GO:0032767 MF 1 copper-dependent protein binding 1 O00244 244 3.34e-03 2 2 1 0.500 0.500 GO:0015680 BP 1 intracellular copper ion transport 1 O00244 244 4.08e-03 26 2 1 0.500 0.038 TF:M06506_0 tf 1 Factor: ZFP62; motif: TSGAGMTTATTY; match class: 0 1 O00244 244 6.67e-03 4 2 1 0.500 0.250 GO:0016531 MF 1 copper chaperone activity 1 O00244 244 6.67e-03 4 2 1 0.500 0.250 GO:0004457 MF 1 lactate dehydrogenase activity 1 P07864 244 6.67e-03 4 2 1 0.500 0.250 GO:0004459 MF 1 L-lactate dehydrogenase activity 1 P07864 244 7.06e-03 45 2 1 0.500 0.022 TF:M05942_0 tf 1 Factor: ZNF700; motif: NTGTCAAAATCN; match class: 0 1 O00244 244 8.34e-03 5 2 1 0.500 0.200 GO:0016530 MF 1 metallochaperone activity 1 O00244 244 1.04e-02 1301 2 2 1.000 0.002 TF:M02219_0 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 0 1 P07864,O00244 244 1.33e-02 8 2 1 0.500 0.125 GO:0006878 BP 1 cellular copper ion homeostasis 1 O00244 244 1.50e-02 9 2 1 0.500 0.111 GO:0006825 BP 1 copper ion transport 1 O00244 244 1.52e-02 97 2 1 0.500 0.010 TF:M06380_0 tf 1 Factor: ZNF787; motif: SGTGGTAMTGATM; match class: 0 1 P07864 244 1.58e-02 101 2 1 0.500 0.010 TF:M05863_0 tf 1 Factor: ZNF491; motif: KGTTCCAGGTTC; match class: 0 1 P07864 244 1.58e-02 101 2 1 0.500 0.010 TF:M05833_0 tf 1 Factor: ZNF572; motif: NNKGRCTGTAGM; match class: 0 1 P07864 244 1.64e-02 105 2 1 0.500 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 P07864 244 1.72e-02 110 2 1 0.500 0.009 TF:M02252_1 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 1 1 P07864 244 1.75e-02 31 2 1 0.500 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P07864 244 1.77e-02 113 2 1 0.500 0.009 TF:M07231_1 tf 1 Factor: TFAP2A; motif: NNNNGCCYSAGGGCA; match class: 1 1 O00244 244 1.83e-02 11 2 1 0.500 0.091 GO:0055070 BP 1 copper ion homeostasis 1 O00244 244 1.98e-02 35 2 1 0.500 0.029 KEGG:04978 keg 1 Mineral absorption 1 O00244 244 2.15e-02 38 2 1 0.500 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P07864 244 2.23e-02 143 2 1 0.500 0.007 TF:M06082_0 tf 1 Factor: ZNF716; motif: NCAGGCAGCGGA; match class: 0 1 P07864 244 2.27e-02 145 2 1 0.500 0.007 TF:M01723_0 tf 1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 0 1 P07864 244 2.39e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 P07864 244 2.43e-02 43 2 1 0.500 0.023 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 P07864 244 2.58e-02 165 2 1 0.500 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 P07864 244 2.72e-02 174 2 1 0.500 0.006 TF:M07137_1 tf 1 Factor: AP-2gamma; motif: NNNNSCCYCAGGSCN; match class: 1 1 O00244 244 2.83e-02 26 2 1 0.500 0.038 REAC:70268 rea 1 Pyruvate metabolism 1 P07864 244 2.94e-02 27 2 1 0.500 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 O00244 244 3.29e-02 211 2 1 0.500 0.005 TF:M05594_0 tf 1 Factor: Staf; motif: GTTTACAAACG; match class: 0 1 P07864 244 3.40e-02 218 2 1 0.500 0.005 TF:M07139_0 tf 1 Factor: USF2; motif: RYCAYGTGACY; match class: 0 1 O00244 244 3.49e-02 62 2 1 0.500 0.016 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P07864 244 3.60e-02 2416 2 2 1.000 0.001 TF:M00965_0 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 0 1 P07864,O00244 244 4.05e-02 2561 2 2 1.000 0.001 TF:M04154_1 tf 1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 1 1 P07864,O00244 244 4.31e-02 277 2 1 0.500 0.004 TF:M05916_0 tf 1 Factor: ZNF407; motif: NGGTGAAARARC; match class: 0 1 P07864 244 4.41e-02 2673 2 2 1.000 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 P07864,O00244 244 4.41e-02 2673 2 2 1.000 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 P07864,O00244 244 4.60e-02 296 2 1 0.500 0.003 TF:M07080_0 tf 1 Factor: C/EBPbeta; motif: KATTGCAYMAY; match class: 0 1 P07864 244 4.66e-02 300 2 1 0.500 0.003 TF:M01182_0 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 0 1 O00244 244 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 P07864 244 5.00e-02 89 2 1 0.500 0.011 KEGG:04922 keg 1 Glucagon signaling pathway 1 P07864 244 5.00e-02 46 2 1 0.500 0.022 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 P07864 245 2.98e-04 28 3 2 0.667 0.071 GO:0017112 MF 1 Rab guanyl-nucleotide exchange factor activity 1 Q96QF0,Q8TBN0 245 4.52e-03 441 3 2 0.667 0.005 MI:hsa-miR-147b mi 1 MI:hsa-miR-147b 1 Q96QF0,Q8N9M5 245 6.57e-03 533 3 2 0.667 0.004 MI:hsa-miR-124 mi 1 MI:hsa-miR-124 1 Q8TBN0,Q8N9M5 245 8.17e-03 145 3 2 0.667 0.014 GO:0005088 MF 1 Ras guanyl-nucleotide exchange factor activity 1 Q96QF0,Q8TBN0 245 9.43e-03 260 3 2 0.667 0.008 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 Q96QF0,Q8N9M5 245 1.04e-02 19 3 1 0.333 0.053 REAC:5620916 rea 1 VxPx cargo-targeting to cilium 1 Q96QF0 245 1.04e-02 19 3 1 0.333 0.053 REAC:5620922 rea 1 BBSome-mediated cargo-targeting to cilium 1 Q96QF0 245 1.40e-02 190 3 2 0.667 0.011 GO:0005085 MF 1 guanyl-nucleotide exchange factor activity 1 Q96QF0,Q8TBN0 245 1.44e-02 8 3 1 0.333 0.125 TF:M06067_0 tf 1 Factor: ZNF195; motif: NAWTCCWAAAGM; match class: 0 1 Q96QF0 245 1.97e-02 522 3 2 0.667 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q96QF0,Q8TBN0 245 2.18e-02 549 3 2 0.667 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q96QF0,Q8TBN0 245 2.41e-02 44 3 1 0.333 0.023 REAC:5620920 rea 1 Cargo trafficking to the periciliary membrane 1 Q96QF0 245 2.53e-02 14 3 1 0.333 0.071 TF:M07317_1 tf 1 Factor: CtBP1; motif: CKCCTGRGCT; match class: 1 1 Q8TBN0 245 3.43e-02 2098 3 3 1.000 0.001 TF:M07296_1 tf 1 Factor: MAF; motif: GCTGAGTCAN; match class: 1 1 Q96QF0,Q8TBN0,Q8N9M5 245 4.09e-02 9 3 1 0.333 0.111 GO:2000406 BP 1 positive regulation of T cell migration 1 Q8N9M5 245 4.15e-02 23 3 1 0.333 0.043 TF:M03993_0 tf 1 Factor: SPDEF; motif: GCAGNAAGAMGTAAMM; match class: 0 1 Q8N9M5 245 4.30e-02 559 3 2 0.667 0.004 TF:M05709_0 tf 1 Factor: znf136; motif: NGRWYGWAGAGA; match class: 0 1 Q96QF0,Q8N9M5 245 4.37e-02 564 3 2 0.667 0.004 TF:M05509_0 tf 1 Factor: ZAC; motif: KGGGGAAGAA; match class: 0 1 Q8TBN0,Q8N9M5 245 4.55e-02 10 3 1 0.333 0.100 GO:2000403 BP 1 positive regulation of lymphocyte migration 1 Q8N9M5 245 4.69e-02 26 3 1 0.333 0.038 TF:M00984_1 tf 1 Factor: PEBP; motif: GNTNACCACARANNK; match class: 1 1 Q8TBN0 245 5.00e-02 92 3 1 0.333 0.011 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 Q96QF0 245 5.00e-02 11 3 1 0.333 0.091 GO:2000404 BP 1 regulation of T cell migration 1 Q8N9M5 245 5.00e-02 2379 3 3 1.000 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q96QF0,Q8TBN0,Q8N9M5 246 2.78e-03 1 2 1 0.500 1.000 GO:0004686 MF 1 elongation factor-2 kinase activity 1 O00418 246 1.70e-02 22 2 1 0.500 0.045 REAC:166208 rea 1 mTORC1-mediated signalling 1 O00418 246 2.08e-02 27 2 1 0.500 0.037 REAC:5601884 rea 1 PIWI-interacting RNA (piRNA) biogenesis 1 O75344 246 2.93e-02 38 2 1 0.500 0.026 REAC:165159 rea 1 mTOR signalling 1 O00418 246 3.01e-02 39 2 1 0.500 0.026 REAC:109703 rea 1 PKB-mediated events 1 O00418 246 3.02e-02 360 2 2 1.000 0.006 TF:M00224_0 tf 1 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN; match class: 0 1 O75344,O00418 246 3.31e-02 43 2 1 0.500 0.023 REAC:1221632 rea 1 Meiotic synapsis 1 O75344 246 3.33e-02 12 2 1 0.500 0.083 GO:0034587 BP 1 piRNA metabolic process 1 O75344 246 3.89e-02 14 2 1 0.500 0.071 GO:0043046 BP 1 DNA methylation involved in gamete generation 1 O75344 246 4.44e-02 16 2 1 0.500 0.062 GO:0005528 MF 1 FK506 binding 1 O75344 246 4.44e-02 16 2 1 0.500 0.062 GO:0005527 MF 1 macrolide binding 1 O75344 246 4.72e-02 17 2 1 0.500 0.059 GO:0099086 CC 1 synaptonemal structure 1 O75344 246 4.72e-02 17 2 1 0.500 0.059 GO:0000795 CC 1 synaptonemal complex 1 O75344 246 5.00e-02 65 2 1 0.500 0.015 REAC:109704 rea 1 PI3K Cascade 1 O00418 246 5.00e-02 107 2 1 0.500 0.009 KEGG:04152 keg 1 AMPK signaling pathway 1 O00418 246 5.00e-02 463 2 2 1.000 0.004 TF:M07216_0 tf 1 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT; match class: 0 1 O75344,O00418 246 5.00e-02 504 2 2 1.000 0.004 MI:hsa-miR-330-3p mi 1 MI:hsa-miR-330-3p 1 O75344,O00418 246 5.00e-02 18 2 1 0.500 0.056 GO:0004683 MF 1 calmodulin-dependent protein kinase activity 1 O00418 247 1.29e-03 119 2 2 1.000 0.017 KEGG:04310 keg 1 Wnt signaling pathway 1 Q14934,P48454 247 1.54e-03 130 2 2 1.000 0.015 KEGG:04921 keg 1 Oxytocin signaling pathway 1 Q14934,P48454 247 1.66e-03 135 2 2 1.000 0.015 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 Q14934,P48454 247 2.03e-03 149 2 2 1.000 0.013 KEGG:04360 keg 1 Axon guidance 1 Q14934,P48454 247 4.35e-03 218 2 2 1.000 0.009 KEGG:05166 keg 1 HTLV-I infection 1 Q14934,P48454 247 1.03e-02 15 2 1 0.500 0.067 REAC:111447 rea 1 Activation of BAD and translocation to mitochondria 1 P48454 247 1.11e-02 6 2 1 0.500 0.167 GO:1902894 BP 1 negative regulation of pri-miRNA transcription from RNA polymerase II promoter 1 Q14934 247 1.44e-02 21 2 1 0.500 0.048 REAC:180024 rea 1 DARPP-32 events 1 P48454 247 1.86e-02 27 2 1 0.500 0.037 REAC:114452 rea 1 Activation of BH3-only proteins 1 P48454 247 2.10e-02 4 2 1 0.500 0.250 TF:M05855_0 tf 1 Factor: ZNF312; motif: GAAGGGAAATGNAAC; match class: 0 1 Q14934 247 2.68e-02 39 2 1 0.500 0.026 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 P48454 247 3.15e-02 17 2 1 0.500 0.059 GO:0061614 BP 1 pri-miRNA transcription from RNA polymerase II promoter 1 Q14934 247 3.15e-02 17 2 1 0.500 0.059 GO:1902893 BP 1 regulation of pri-miRNA transcription from RNA polymerase II promoter 1 Q14934 247 4.35e-02 47 2 1 0.500 0.021 KEGG:04924 keg 1 Renin secretion 1 P48454 247 4.45e-02 48 2 1 0.500 0.021 KEGG:05014 keg 1 Amyotrophic lateral sclerosis (ALS) 1 P48454 247 4.63e-02 25 2 1 0.500 0.040 GO:1900740 BP 1 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P48454 247 4.63e-02 25 2 1 0.500 0.040 GO:1900739 BP 1 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P48454 247 4.72e-02 9 2 1 0.500 0.111 TF:M05569_0 tf 1 Factor: FEZF1; motif: GAAGGGAAATGNAAC; match class: 0 1 Q14934 247 4.94e-02 280 2 1 0.500 0.004 MI:hsa-miR-335* mi 1 MI:hsa-miR-335* 1 P48454 247 5.00e-02 54 2 1 0.500 0.019 KEGG:05031 keg 1 Amphetamine addiction 1 P48454 247 5.00e-02 27 2 1 0.500 0.037 GO:0001844 BP 1 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P48454 247 5.00e-02 27 2 1 0.500 0.037 GO:0051204 BP 1 protein insertion into mitochondrial membrane 1 P48454 247 5.00e-02 54 2 1 0.500 0.019 KEGG:04370 keg 1 VEGF signaling pathway 1 P48454 247 5.00e-02 73 2 1 0.500 0.014 REAC:111885 rea 1 Opioid Signalling 1 P48454 248 2.34e-03 2 2 1 0.500 0.500 GO:0010265 BP 1 SCF complex assembly 1 O75155 248 3.51e-03 3 2 1 0.500 0.333 GO:0034455 CC 1 t-UTP complex 1 Q9H583 248 4.03e-03 808 2 2 1.000 0.002 TF:M01796_0 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 0 1 Q9H583,O75155 248 4.24e-03 27 2 1 0.500 0.037 TF:M07402_1 tf 1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 1 1 O75155 248 5.18e-03 33 2 1 0.500 0.030 TF:M05741_0 tf 1 Factor: ZNF718; motif: NGGGGCWTCAGM; match class: 0 1 O75155 248 5.78e-03 968 2 2 1.000 0.002 TF:M02271_1 tf 1 Factor: HOXA5; motif: CDBWAATK; match class: 1 1 Q9H583,O75155 248 5.81e-03 37 2 1 0.500 0.027 TF:M06762_0 tf 1 Factor: ZNF222; motif: NGGTCRAAACGA; match class: 0 1 O75155 248 7.37e-03 47 2 1 0.500 0.021 TF:M07207_1 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 1 1 O75155 248 1.08e-02 1322 2 2 1.000 0.002 TF:M00113_0 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 0 1 Q9H583,O75155 248 1.19e-02 76 2 1 0.500 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 O75155 248 1.22e-02 78 2 1 0.500 0.013 TF:M07339_1 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 1 1 O75155 248 1.38e-02 88 2 1 0.500 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 Q9H583 248 1.64e-02 14 2 1 0.500 0.071 GO:0045943 BP 1 positive regulation of transcription from RNA polymerase I promoter 1 Q9H583 248 1.65e-02 1633 2 2 1.000 0.001 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 Q9H583,O75155 248 2.41e-02 154 2 1 0.500 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 Q9H583 248 2.44e-02 156 2 1 0.500 0.006 TF:M01147_0 tf 1 Factor: DMRT2; motif: NAWWTTGWTACATTGW; match class: 0 1 Q9H583 248 2.57e-02 22 2 1 0.500 0.045 GO:0006356 BP 1 regulation of transcription from RNA polymerase I promoter 1 Q9H583 248 2.64e-02 2068 2 2 1.000 0.001 TF:M03883_0 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 0 1 Q9H583,O75155 248 2.68e-02 172 2 1 0.500 0.006 TF:M04254_1 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 1 1 Q9H583 248 2.75e-02 2110 2 2 1.000 0.001 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 Q9H583,O75155 248 2.78e-02 741 2 2 1.000 0.003 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 Q9H583,O75155 248 2.78e-02 741 2 2 1.000 0.003 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 Q9H583,O75155 248 2.82e-02 2137 2 2 1.000 0.001 TF:M00789_1 tf 1 Factor: GATA; motif: WGATARN; match class: 1 1 Q9H583,O75155 248 2.82e-02 2137 2 2 1.000 0.001 TF:M03216_1 tf 1 Factor: GATA-6; motif: AGATAAN; match class: 1 1 Q9H583,O75155 248 2.84e-02 2144 2 2 1.000 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 Q9H583,O75155 248 2.94e-02 762 2 2 1.000 0.003 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 Q9H583,O75155 248 3.03e-02 194 2 1 0.500 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 Q9H583 248 3.04e-02 26 2 1 0.500 0.038 GO:0030515 MF 1 snoRNA binding 1 Q9H583 248 3.04e-02 26 2 1 0.500 0.038 GO:0030686 CC 1 90S preribosome 1 Q9H583 248 3.17e-02 791 2 2 1.000 0.003 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 Q9H583,O75155 248 3.38e-02 217 2 1 0.500 0.005 TF:M06534_0 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 0 1 O75155 248 3.54e-02 227 2 1 0.500 0.004 TF:M04169_1 tf 1 Factor: FIGLA; motif: NMCACCTGKN; match class: 1 1 O75155 248 3.58e-02 230 2 1 0.500 0.004 TF:M04364_0 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 0 1 Q9H583 248 3.70e-02 238 2 1 0.500 0.004 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 Q9H583 248 3.74e-02 32 2 1 0.500 0.031 GO:0032040 CC 1 small-subunit processome 1 Q9H583 248 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q9H583 248 3.87e-02 249 2 1 0.500 0.004 TF:M00405_1 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 1 1 Q9H583 248 3.89e-02 250 2 1 0.500 0.004 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 Q9H583 248 3.94e-02 253 2 1 0.500 0.004 TF:M05528_0 tf 1 Factor: ZAC; motif: KGWTGGGSAT; match class: 0 1 O75155 248 4.04e-02 260 2 1 0.500 0.004 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 Q9H583 248 4.07e-02 896 2 2 1.000 0.002 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q9H583,O75155 248 4.09e-02 35 2 1 0.500 0.029 GO:0000462 BP 1 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q9H583 248 4.21e-02 392 2 2 1.000 0.005 MI:hsa-miR-551b mi 1 MI:hsa-miR-551b 1 Q9H583,O75155 248 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q9H583,O75155 248 4.31e-02 922 2 2 1.000 0.002 GO:0010628 BP 1 positive regulation of gene expression 1 Q9H583,O75155 248 4.41e-02 933 2 2 1.000 0.002 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 Q9H583,O75155 248 4.46e-02 287 2 1 0.500 0.003 TF:M01797_1 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 1 1 O75155 248 4.52e-02 2705 2 2 1.000 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q9H583,O75155 248 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 Q9H583 248 4.52e-02 291 2 1 0.500 0.003 TF:M00436_1 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 1 1 Q9H583 248 4.54e-02 292 2 1 0.500 0.003 TF:M04106_0 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 0 1 O75155 248 4.54e-02 292 2 1 0.500 0.003 TF:M04259_1 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 1 1 Q9H583 248 4.54e-02 292 2 1 0.500 0.003 TF:M04255_1 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 1 1 Q9H583 248 4.54e-02 292 2 1 0.500 0.003 TF:M04247_1 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 1 1 Q9H583 248 4.56e-02 408 2 2 1.000 0.005 MI:hsa-miR-99a mi 1 MI:hsa-miR-99a 1 Q9H583,O75155 248 4.63e-02 956 2 2 1.000 0.002 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q9H583,O75155 248 4.78e-02 971 2 2 1.000 0.002 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q9H583,O75155 248 4.79e-02 418 2 2 1.000 0.005 MI:hsa-miR-100 mi 1 MI:hsa-miR-100 1 Q9H583,O75155 248 5.00e-02 993 2 2 1.000 0.002 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q9H583,O75155 248 5.00e-02 74 2 1 0.500 0.014 KEGG:03008 keg 1 Ribosome biogenesis in eukaryotes 1 Q9H583 249 2.88e-29 671 24 24 1.000 0.036 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,P17040,Q96JS3,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,O14709,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 2.88e-29 671 24 24 1.000 0.036 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,P17040,Q96JS3,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,O14709,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 2.21e-14 473 24 15 0.625 0.032 GO:0043565 MF 1 sequence-specific DNA binding 1 O14978,O14771,P17029,P17040,Q96JS3,Q53GI3,Q9Y5A6,Q9UNY5,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0 249 7.39e-13 922 24 17 0.708 0.018 GO:0003677 MF 1 DNA binding 1 O14978,O14771,Q15697,P17029,P17040,Q96JS3,Q53GI3,Q9Y5A6,Q9UNY5,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.10e-07 309 24 9 0.375 0.029 GO:0000981 MF 1 RNA polymerase II transcription factor activity, sequence-specific DNA binding 1 Q9NWS9,Q15697,Q8TBC5,Q8IWY8,Q9NX65,Q9Y5A6,Q8N0Y2,Q9BRR0,Q6R2W3 249 5.80e-07 2136 24 17 0.708 0.008 GO:0003676 MF 1 nucleic acid binding 1 O14978,O14771,Q15697,P17029,P17040,Q96JS3,Q53GI3,Q9Y5A6,Q9UNY5,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.46e-06 4430 24 22 0.917 0.005 GO:0005634 CC 1 nucleus 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,Q96JS3,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.28e-05 2612 24 17 0.708 0.007 GO:1901363 MF 1 heterocyclic compound binding 1 O14978,O14771,Q15697,P17029,P17040,Q96JS3,Q53GI3,Q9Y5A6,Q9UNY5,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.69e-05 2660 24 17 0.708 0.006 GO:0097159 MF 1 organic cyclic compound binding 1 O14978,O14771,Q15697,P17029,P17040,Q96JS3,Q53GI3,Q9Y5A6,Q9UNY5,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 6.37e-05 2919 24 17 0.708 0.006 TF:M02054_0 tf 1 Factor: ELF2; motif: CCCGGAARYN; match class: 0 1 O14978,O14771,Q15697,P17029,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 1.26e-04 628 24 9 0.375 0.014 REAC:212436 rea 1 Generic Transcription Pathway 1 O14978,Q9NWS9,O14771,P17029,Q9NX65,Q53GI3,O14709,Q969J2,Q9BRR0 249 2.64e-04 2 24 2 0.083 1.000 TF:M06603_1 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 1 1 Q15697,Q9NX65 249 1.34e-03 8065 24 24 1.000 0.003 TF:M00032_0 tf 1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 0 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,P17040,Q96JS3,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,O14709,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.92e-03 1757 24 12 0.500 0.007 TF:M02056_1 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 1 O14978,O14771,Q15697,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P57086,Q86W11,Q6R2W3 249 2.25e-03 2861 24 15 0.625 0.005 TF:M02053_0 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 0 1 O14978,O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P10073,O14709,Q8NF99,Q86W11,Q3MJ62,Q9BRR0,Q6R2W3 249 2.54e-03 516 24 7 0.292 0.014 TF:M02054_1 tf 1 Factor: ELF2; motif: CCCGGAARYN; match class: 1 1 O14978,Q15697,Q8IWY8,Q9NX65,Q53GI3,P57086,O14709 249 4.27e-03 4887 24 19 0.792 0.004 TF:M02074_0 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 0 1 O14978,Q9NWS9,O14771,Q15697,P17029,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P57086,P17028,O14709,Q8NF99,Q86W11,Q3MJ62,Q9BRR0,Q6R2W3 249 4.83e-03 5486 24 20 0.833 0.004 TF:M02056_0 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 0 1 O14978,O14771,Q15697,Q8TBC5,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,O14709,Q8NF99,Q86W11,Q3MJ62,Q9BRR0,Q6R2W3 249 4.90e-03 1603 24 11 0.458 0.007 TF:M01214_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 O14978,O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P57086,P17028,O14709 249 4.90e-03 1603 24 11 0.458 0.007 TF:M02055_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 O14978,O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P57086,P17028,O14709 249 5.13e-03 3481 24 16 0.667 0.005 TF:M02068_0 tf 1 Factor: etv3; motif: ACCGGAAGYN; match class: 0 1 O14978,O14771,Q15697,P17029,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P57086,P17028,O14709,Q8NF99,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 5.95e-03 348 24 4 0.167 0.011 MI:hsa-miR-15a* mi 1 MI:hsa-miR-15a* 1 Q9NWS9,Q8NF99,Q969J2,Q9BRR0 249 6.06e-03 6671 24 22 0.917 0.003 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,Q96JS3,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,Q8NF99,Q86W11,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 8.25e-03 3608 24 16 0.667 0.004 TF:M00032_1 tf 1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 1 O14978,Q9NWS9,O14771,Q15697,P17029,Q8TBC5,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q9UNY5,P57086,P17028,O14709,Q8NF99,Q3MJ62 249 1.01e-02 405 24 4 0.167 0.010 MI:hsa-miR-618 mi 1 MI:hsa-miR-618 1 Q8TBC5,Q96JS3,Q9Y5A6,O14709 249 1.02e-02 2071 24 12 0.500 0.006 TF:M03982_0 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 0 1 O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 1.04e-02 3671 24 16 0.667 0.004 TF:M02066_0 tf 1 Factor: PEA3; motif: RCCGGAAGYN; match class: 0 1 O14978,O14771,Q15697,P17029,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P57086,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 1.04e-02 5738 24 20 0.833 0.003 TF:M02067_0 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 0 1 O14978,O14771,Q15697,P17029,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,P10073,O14709,Q8NF99,Q969J2,Q3MJ62,Q9BRR0,Q6R2W3 249 1.05e-02 879 24 8 0.333 0.009 TF:M02066_1 tf 1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 1 O14978,O14771,P17029,Q8IWY8,Q53GI3,P57086,O14709,Q3MJ62 249 1.16e-02 422 24 4 0.167 0.009 MI:hsa-miR-490-5p mi 1 MI:hsa-miR-490-5p 1 O14978,P17040,Q8NF99,Q969J2 249 1.37e-02 443 24 4 0.167 0.009 MI:hsa-miR-629 mi 1 MI:hsa-miR-629 1 Q96JS3,Q53GI3,Q8N0Y2,Q8NF99 249 1.39e-02 445 24 4 0.167 0.009 MI:hsa-miR-499-3p mi 1 MI:hsa-miR-499-3p 1 O14978,Q8TBC5,P17028,Q9BRR0 249 1.40e-02 467 24 6 0.250 0.013 TF:M01258_1 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 1 1 O14771,P17029,Q8IWY8,Q53GI3,P57086,O14709 249 1.42e-02 448 24 4 0.167 0.009 MI:mmu-miR-691 mi 1 MI:mmu-miR-691 1 O14978,P17040,Q8NF99,Q3MJ62 249 1.59e-02 463 24 4 0.167 0.009 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 O14978,Q96JS3,Q53GI3,Q86W11 249 1.64e-02 481 24 6 0.250 0.012 TF:M02053_1 tf 1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 1 O14978,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6 249 1.71e-02 258 24 3 0.125 0.012 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 Q53GI3,Q9Y5A6,Q8NF99 249 1.97e-02 272 24 3 0.125 0.011 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 Q9NWS9,Q96JS3,Q86W11 249 1.97e-02 5379 24 19 0.792 0.004 TF:M02071_1 tf 1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 1 O14978,Q9NWS9,O14771,Q15697,P17029,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P10073,O14709,Q8NF99,Q86W11,Q3MJ62,Q6R2W3 249 2.08e-02 278 24 3 0.125 0.011 MI:hsa-miR-550* mi 1 MI:hsa-miR-550* 1 Q86W11,Q969J2,Q9BRR0 249 2.33e-02 290 24 3 0.125 0.010 MI:hsa-miR-132* mi 1 MI:hsa-miR-132* 1 Q8NF99,Q969J2,Q9BRR0 249 2.47e-02 5457 24 19 0.792 0.003 TF:M01214_0 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 0 1 O14978,O14771,Q15697,P17029,Q8TBC5,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 2.47e-02 5457 24 19 0.792 0.003 TF:M02055_0 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 0 1 O14978,O14771,Q15697,P17029,Q8TBC5,P17040,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,Q8N0Y2,Q9UNY5,P57086,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 2.75e-02 1010 24 8 0.333 0.008 TF:M03832_0 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 0 1 Q9NWS9,Q96JS3,Q8IWY8,Q9Y5A6,O14709,Q8NF99,Q9BRR0,Q6R2W3 249 2.94e-02 1949 24 11 0.458 0.006 TF:M02067_1 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 1 1 O14978,O14771,Q15697,P17029,P17040,Q8IWY8,Q9NX65,Q53GI3,P57086,O14709,Q3MJ62 249 3.08e-02 2702 24 13 0.542 0.005 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 O14771,Q15697,P17029,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 3.15e-02 3114 24 14 0.583 0.004 TF:M03983_0 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 0 1 O14771,Q15697,P17029,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P57086,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 3.15e-02 326 24 3 0.125 0.009 MI:hsa-miR-182* mi 1 MI:hsa-miR-182* 1 Q9NX65,Q9Y5A6,Q969J2 249 3.22e-02 329 24 3 0.125 0.009 MI:hsa-miR-33a* mi 1 MI:hsa-miR-33a* 1 Q96JS3,Q9Y5A6,Q86W11 249 3.37e-02 335 24 3 0.125 0.009 MI:hsa-miR-636 mi 1 MI:hsa-miR-636 1 Q9NWS9,Q9NX65,P57086 249 3.58e-02 343 24 3 0.125 0.009 MI:hsa-miR-888* mi 1 MI:hsa-miR-888* 1 P17040,Q9Y5A6,O14709 249 3.80e-02 351 24 3 0.125 0.009 MI:hsa-miR-17* mi 1 MI:hsa-miR-17* 1 Q96JS3,Q9Y5A6,Q86W11 249 3.82e-02 1060 24 8 0.333 0.008 TF:M05427_0 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 0 1 O14771,Q96JS3,P57086,O14709,Q8NF99,Q86W11,Q969J2,Q9BRR0 249 3.88e-02 2375 24 12 0.500 0.005 TF:M02072_0 tf 1 Factor: Pet-1; motif: ACCGGAWRTN; match class: 0 1 O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,P17028,O14709,Q8NF99,Q3MJ62,Q9BRR0,Q6R2W3 249 4.07e-02 361 24 3 0.125 0.008 MI:hsa-miR-600 mi 1 MI:hsa-miR-600 1 Q96JS3,Q53GI3,Q9BRR0 249 4.42e-02 373 24 3 0.125 0.008 MI:hsa-miR-412 mi 1 MI:hsa-miR-412 1 O14978,Q15697,Q86W11 249 4.63e-02 380 24 3 0.125 0.008 MI:hsa-miR-29b-2* mi 1 MI:hsa-miR-29b-2* 1 Q96JS3,Q53GI3,Q9BRR0 249 5.00e-02 1263 24 9 0.375 0.007 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 O14771,P17029,P17040,Q96JS3,Q8IWY8,Q9Y5A6,P17028,Q8NF99,Q86W11 249 5.00e-02 1485 24 9 0.375 0.006 REAC:74160 rea 1 Gene Expression 1 O14978,Q9NWS9,O14771,P17029,Q9NX65,Q53GI3,O14709,Q969J2,Q9BRR0 249 5.00e-02 1723 24 10 0.417 0.006 TF:M02069_0 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 0 1 O14771,Q15697,Q8IWY8,Q9NX65,Q53GI3,Q9Y5A6,O14709,Q8NF99,Q9BRR0,Q6R2W3 250 5.58e-03 1 4 1 0.250 1.000 OMIM:302060 omi 1 BARTH SYNDROME; BTHS;;CARDIOSKELETAL MYOPATHY WITH NEUTROPENIA AND ABNORMAL MITOCHONDRIA;;3-@METHYLGLUTACONIC ACIDURIA, TYPE II; MGCA2;;MGA, TYPE II; MGA2 1 Q16635 250 8.34e-03 1 4 1 0.250 1.000 GO:0030294 MF 1 receptor signaling protein tyrosine kinase inhibitor activity 1 Q12891 250 8.34e-03 1 4 1 0.250 1.000 GO:0046126 BP 1 pyrimidine deoxyribonucleoside biosynthetic process 1 Q86XF0 250 8.34e-03 1 4 1 0.250 1.000 GO:0070295 BP 1 renal water absorption 1 Q12891 250 8.34e-03 1 4 1 0.250 1.000 GO:0046105 BP 1 thymidine biosynthetic process 1 Q86XF0 250 8.34e-03 1 4 1 0.250 1.000 GO:0033906 MF 1 hyaluronoglucuronidase activity 1 Q12891 250 8.34e-03 1 4 1 0.250 1.000 GO:0046120 BP 1 deoxyribonucleoside biosynthetic process 1 Q86XF0 250 1.45e-02 549 4 2 0.500 0.004 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 Q12891,Q16635 250 1.67e-02 2 4 1 0.250 0.500 GO:0003097 BP 1 renal water transport 1 Q12891 250 1.67e-02 2 4 1 0.250 0.500 GO:0019087 BP 1 transformation of host cell by virus 1 Q12891 250 1.67e-02 2 4 1 0.250 0.500 GO:0010764 BP 1 negative regulation of fibroblast migration 1 Q12891 250 1.67e-02 2 4 1 0.250 0.500 GO:0004146 MF 1 dihydrofolate reductase activity 1 Q86XF0 250 2.07e-02 661 4 2 0.500 0.003 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 Q16635,Q86XF0 250 2.50e-02 3 4 1 0.250 0.333 GO:0046125 BP 1 pyrimidine deoxyribonucleoside metabolic process 1 Q86XF0 250 2.50e-02 3 4 1 0.250 0.333 GO:0046104 BP 1 thymidine metabolic process 1 Q86XF0 250 2.50e-02 3 4 1 0.250 0.333 GO:0004415 MF 1 hyalurononglucosaminidase activity 1 Q12891 250 2.50e-02 6 4 1 0.250 0.167 REAC:1482798 rea 1 Acyl chain remodeling of CL 1 Q16635 250 2.51e-02 13 4 1 0.250 0.077 KEGG:00531 keg 1 Glycosaminoglycan degradation 1 Q12891 250 2.70e-02 14 4 1 0.250 0.071 KEGG:00790 keg 1 Folate biosynthesis 1 Q86XF0 250 3.01e-02 798 4 3 0.750 0.004 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q12891,Q16635,Q86XF0 250 3.33e-02 4 4 1 0.250 0.250 GO:0030292 MF 1 protein tyrosine kinase inhibitor activity 1 Q12891 250 3.33e-02 4 4 1 0.250 0.250 GO:0035810 BP 1 positive regulation of urine volume 1 Q12891 250 3.33e-02 4 4 1 0.250 0.250 GO:0047184 MF 1 1-acylglycerophosphocholine O-acyltransferase activity 1 Q16635 250 3.47e-02 18 4 1 0.250 0.056 KEGG:00670 keg 1 One carbon pool by folate 1 Q86XF0 250 4.17e-02 5 4 1 0.250 0.200 GO:0044800 BP 1 multi-organism membrane fusion 1 Q12891 250 4.17e-02 5 4 1 0.250 0.200 GO:0039663 BP 1 membrane fusion involved in viral entry into host cell 1 Q12891 250 4.17e-02 5 4 1 0.250 0.200 GO:0042117 BP 1 monocyte activation 1 Q12891 250 4.17e-02 5 4 1 0.250 0.200 GO:0035965 BP 1 cardiolipin acyl-chain remodeling 1 Q16635 250 4.17e-02 5 4 1 0.250 0.200 GO:0009120 BP 1 deoxyribonucleoside metabolic process 1 Q86XF0 250 4.17e-02 5 4 1 0.250 0.200 GO:0019064 BP 1 fusion of virus membrane with host plasma membrane 1 Q12891 250 4.17e-02 5 4 1 0.250 0.200 GO:0006833 BP 1 water transport 1 Q12891 250 4.17e-02 10 4 1 0.250 0.100 REAC:2160916 rea 1 Hyaluronan uptake and degradation 1 Q12891 250 5.00e-02 1 4 1 0.250 1.000 HP:0003756 hp 1 Skeletal myopathy 1 Q16635 250 5.00e-02 26 4 1 0.250 0.038 KEGG:01523 keg 1 Antifolate resistance 1 Q86XF0 250 5.00e-02 1 4 1 0.250 1.000 HP:0004913 hp 1 Intermittent lactic acidemia 1 Q16635 250 5.00e-02 2 4 1 0.250 0.500 TF:M03956_1 tf 1 Factor: ONECUT2; motif: NAAAAATCRATANN; match class: 1 1 Q16635 250 5.00e-02 2 4 1 0.250 0.500 TF:M03957_1 tf 1 Factor: ONECUT3; motif: NAAAAATCRATAAN; match class: 1 1 Q16635 250 5.00e-02 6 4 1 0.250 0.167 GO:0071493 BP 1 cellular response to UV-B 1 Q12891 250 5.00e-02 2 4 1 0.250 0.500 TF:M00639_1 tf 1 Factor: HNF-6; motif: HWAAATCAATAW; match class: 1 1 Q16635 250 5.00e-02 6 4 1 0.250 0.167 GO:0031362 CC 1 anchored component of external side of plasma membrane 1 Q12891 250 5.00e-02 6 4 1 0.250 0.167 GO:0035809 BP 1 regulation of urine volume 1 Q12891 250 5.00e-02 12 4 1 0.250 0.083 REAC:2142845 rea 1 Hyaluronan metabolism 1 Q12891 251 1.33e-03 1 2 1 0.500 1.000 OMIM:603373 omi 1 HYPERTHYROIDISM, FAMILIAL GESTATIONAL 1 P16473 251 1.33e-03 1 2 1 0.500 1.000 OMIM:616647 omi 1 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 35; EIEE35 1 Q9BY32 251 1.33e-03 1 2 1 0.500 1.000 OMIM:613850 omi 1 INOSINE TRIPHOSPHATASE DEFICIENCY;;INOSINE TRIPHOSPHATE PYROPHOSPHOHYDROLASE DEFICIENCY 1 Q9BY32 251 1.33e-03 1 2 1 0.500 1.000 OMIM:609152 omi 1 HYPERTHYROIDISM, NONAUTOIMMUNE;;HYPERTHYROIDISM, CONGENITAL NONAUTOIMMUNE;;HYPERTHYROIDISM, NONAUTOIMMUNE, AUTOSOMAL DOMINANT;;TOXIC THYROID HYPERPLASIA, AUTOSOMAL DOMINANT 1 P16473 251 1.38e-03 417 2 2 1.000 0.005 MI:hsa-miR-205 mi 1 MI:hsa-miR-205 1 Q9BY32,P16473 251 1.62e-03 1 2 1 0.500 1.000 GO:0036220 MF 1 ITP diphosphatase activity 1 Q9BY32 251 1.62e-03 1 2 1 0.500 1.000 GO:0036222 MF 1 XTP diphosphatase activity 1 Q9BY32 251 2.26e-03 4 2 1 0.500 0.250 REAC:375281 rea 1 Hormone ligand-binding receptors 1 P16473 251 2.36e-03 545 2 2 1.000 0.004 MI:hsa-miR-518a-5p mi 1 MI:hsa-miR-518a-5p 1 Q9BY32,P16473 251 3.23e-03 2 2 1 0.500 0.500 GO:0035870 MF 1 dITP diphosphatase activity 1 Q9BY32 251 3.23e-03 2 2 1 0.500 0.500 GO:0004996 MF 1 thyroid-stimulating hormone receptor activity 1 P16473 251 1.25e-02 1 2 1 0.500 1.000 HP:0012188 hp 1 Hyperemesis gravidarum 1 P16473 251 1.29e-02 8 2 1 0.500 0.125 GO:0016500 MF 1 protein-hormone receptor activity 1 P16473 251 1.29e-02 8 2 1 0.500 0.125 GO:0047429 MF 1 nucleoside-triphosphate diphosphatase activity 1 Q9BY32 251 1.41e-02 450 2 2 1.000 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 Q9BY32,P16473 251 2.50e-02 2 2 1 0.500 0.500 HP:0100028 hp 1 Ectopic thyroid 1 P16473 251 2.50e-02 2 2 1 0.500 0.500 HP:0008191 hp 1 Thyroid agenesis 1 P16473 251 2.50e-02 2 2 1 0.500 0.500 HP:0008249 hp 1 Thyroid hyperplasia 1 P16473 251 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q9BY32,P16473 251 3.55e-02 22 2 1 0.500 0.045 GO:0007190 BP 1 activation of adenylate cyclase activity 1 P16473 251 3.71e-02 23 2 1 0.500 0.043 GO:0045762 BP 1 positive regulation of adenylate cyclase activity 1 P16473 251 3.75e-02 3 2 1 0.500 0.333 HP:0005990 hp 1 Thyroid hypoplasia 1 P16473 251 3.75e-02 3 2 1 0.500 0.333 HP:0004491 hp 1 Large posterior fontanelle 1 P16473 251 3.77e-02 67 2 1 0.500 0.015 REAC:418555 rea 1 G alpha (s) signalling events 1 P16473 251 3.86e-02 27 2 1 0.500 0.037 KEGG:05320 keg 1 Autoimmune thyroid disease 1 P16473 251 4.33e-02 77 2 1 0.500 0.013 REAC:373076 rea 1 Class A/1 (Rhodopsin-like receptors) 1 P16473 251 4.59e-02 260 2 1 0.500 0.004 MI:mmu-miR-207 mi 1 MI:mmu-miR-207 1 Q9BY32 251 4.68e-02 29 2 1 0.500 0.034 GO:0031281 BP 1 positive regulation of cyclase activity 1 P16473 251 4.68e-02 29 2 1 0.500 0.034 GO:0051349 BP 1 positive regulation of lyase activity 1 P16473 251 4.84e-02 30 2 1 0.500 0.033 GO:0030819 BP 1 positive regulation of cAMP biosynthetic process 1 P16473 251 5.00e-02 89 2 1 0.500 0.011 REAC:15869 rea 1 Metabolism of nucleotides 1 Q9BY32 251 5.00e-02 38 2 1 0.500 0.026 OMIM:308350 omi 1 Early Infantile Epileptic Encephalopathy 1 Q9BY32 251 5.00e-02 31 2 1 0.500 0.032 GO:0030816 BP 1 positive regulation of cAMP metabolic process 1 P16473 251 5.00e-02 35 2 1 0.500 0.029 KEGG:00983 keg 1 Drug metabolism - other enzymes 1 Q9BY32 251 5.00e-02 4 2 1 0.500 0.250 HP:0001615 hp 1 Hoarse cry 1 P16473 251 5.00e-02 302 2 2 1.000 0.007 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q9BY32,P16473 251 5.00e-02 31 2 1 0.500 0.032 GO:0008528 MF 1 G-protein coupled peptide receptor activity 1 P16473 251 5.00e-02 4 2 1 0.500 0.250 HP:0008188 hp 1 Thyroid dysgenesis 1 P16473 252 8.93e-03 628 2 2 1.000 0.003 REAC:212436 rea 1 Generic Transcription Pathway 1 O14771,O14709 252 1.61e-02 1369 2 2 1.000 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 O14771,O14709 252 2.04e-02 467 2 2 1.000 0.004 TF:M01258_1 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 1 1 O14771,O14709 252 2.66e-02 533 2 2 1.000 0.004 TF:M03791_1 tf 1 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY; match class: 1 1 O14771,O14709 252 3.10e-02 13 2 1 0.500 0.077 TF:M05794_0 tf 1 Factor: ZNF621; motif: NGGTTCGWCGTA; match class: 0 1 O14709 252 3.70e-02 629 2 2 1.000 0.003 TF:M03983_1 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 1 1 O14771,O14709 252 5.00e-02 671 2 2 1.000 0.003 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 O14771,O14709 252 5.00e-02 731 2 2 1.000 0.003 TF:M02068_1 tf 1 Factor: etv3; motif: ACCGGAAGYN; match class: 1 1 O14771,O14709 252 5.00e-02 1485 2 2 1.000 0.001 REAC:74160 rea 1 Gene Expression 1 O14771,O14709 252 5.00e-02 671 2 2 1.000 0.003 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 O14771,O14709 253 1.83e-03 5 2 1 0.500 0.200 REAC:68911 rea 1 G2 Phase 1 O00716 253 4.02e-03 11 2 1 0.500 0.091 REAC:68689 rea 1 CDC6 association with the ORC:origin complex 1 O00716 253 4.66e-03 22 2 1 0.500 0.045 TF:M06402_0 tf 1 Factor: ZNF493; motif: NGGTCAAAAAGA; match class: 0 1 Q5H9I0 253 5.12e-03 14 2 1 0.500 0.071 REAC:69298 rea 1 Association of licensing factors with the pre-replicative complex 1 O00716 253 5.93e-03 28 2 1 0.500 0.036 TF:M05677_0 tf 1 Factor: ZNF816A; motif: KGGGAAAAMGGM; match class: 0 1 Q5H9I0 253 8.43e-03 1006 2 2 1.000 0.002 TF:M07141_1 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 1 1 O00716,Q5H9I0 253 9.49e-03 26 2 1 0.500 0.038 REAC:1912408 rea 1 Pre-NOTCH Transcription and Translation 1 O00716 253 1.10e-02 30 2 1 0.500 0.033 REAC:2559585 rea 1 Oncogene Induced Senescence 1 O00716 253 1.19e-02 1193 2 2 1.000 0.002 TF:M00998_0 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 0 1 O00716,Q5H9I0 253 1.21e-02 57 2 1 0.500 0.018 TF:M06694_0 tf 1 Factor: ZNF160; motif: NGGTCAGCCAGC; match class: 0 1 Q5H9I0 253 1.23e-02 58 2 1 0.500 0.017 TF:M06232_0 tf 1 Factor: ZNF234; motif: NGTGCAAAAYKG; match class: 0 1 O00716 253 1.35e-02 37 2 1 0.500 0.027 REAC:69231 rea 1 Cyclin D associated events in G1 1 O00716 253 1.35e-02 37 2 1 0.500 0.027 REAC:69236 rea 1 G1 Phase 1 O00716 253 1.53e-02 42 2 1 0.500 0.024 REAC:1912422 rea 1 Pre-NOTCH Expression and Processing 1 O00716 253 1.54e-02 73 2 1 0.500 0.014 TF:M04083_1 tf 1 Factor: POU3F4; motif: TATGCWAAT; match class: 1 1 O00716 253 1.59e-02 75 2 1 0.500 0.013 TF:M04070_1 tf 1 Factor: POU2F1; motif: NWTATGCWAATN; match class: 1 1 O00716 253 1.60e-02 1387 2 2 1.000 0.001 TF:M00917_1 tf 1 Factor: CREB; motif: CNNTGACGTMA; match class: 1 1 O00716,Q5H9I0 253 1.67e-02 1418 2 2 1.000 0.001 TF:M07434_0 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 0 1 O00716,Q5H9I0 253 1.97e-02 93 2 1 0.500 0.011 TF:M06674_0 tf 1 Factor: znf587; motif: NGGGRCTGATGA; match class: 0 1 Q5H9I0 253 2.01e-02 1553 2 2 1.000 0.001 TF:M00801_1 tf 1 Factor: CREB; motif: CGTCAN; match class: 1 1 O00716,Q5H9I0 253 2.08e-02 36 2 1 0.500 0.028 KEGG:05219 keg 1 Bladder cancer 1 O00716 253 2.11e-02 100 2 1 0.500 0.010 TF:M06551_0 tf 1 Factor: znf417; motif: NGGGRCTGATGA; match class: 0 1 Q5H9I0 253 2.15e-02 102 2 1 0.500 0.010 TF:M07089_1 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 1 1 Q5H9I0 253 2.20e-02 104 2 1 0.500 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 O00716 253 2.42e-02 1706 2 2 1.000 0.001 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 O00716,Q5H9I0 253 2.44e-02 67 2 1 0.500 0.015 REAC:68867 rea 1 Assembly of the pre-replicative complex 1 O00716 253 2.50e-02 1732 2 2 1.000 0.001 TF:M07248_1 tf 1 Factor: CREB1; motif: NNNNTGACGTNANNN; match class: 1 1 O00716,Q5H9I0 253 2.66e-02 126 2 1 0.500 0.008 TF:M07417_1 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 1 1 Q5H9I0 253 2.73e-02 75 2 1 0.500 0.013 REAC:69304 rea 1 Regulation of DNA replication 1 O00716 253 2.73e-02 75 2 1 0.500 0.013 REAC:2559580 rea 1 Oxidative Stress Induced Senescence 1 O00716 253 2.83e-02 134 2 1 0.500 0.007 TF:M04074_1 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 1 1 O00716 253 3.00e-02 52 2 1 0.500 0.019 KEGG:05223 keg 1 Non-small cell lung cancer 1 O00716 253 3.02e-02 83 2 1 0.500 0.012 REAC:68874 rea 1 M/G1 Transition 1 O00716 253 3.02e-02 83 2 1 0.500 0.012 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 O00716 253 3.06e-02 1916 2 2 1.000 0.001 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 O00716,Q5H9I0 253 3.11e-02 54 2 1 0.500 0.019 KEGG:05218 keg 1 Melanoma 1 O00716 253 3.25e-02 154 2 1 0.500 0.006 TF:M07384_1 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 1 1 Q5H9I0 253 3.29e-02 57 2 1 0.500 0.018 KEGG:05214 keg 1 Glioma 1 O00716 253 3.29e-02 156 2 1 0.500 0.006 TF:M00113_1 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 1 1 O00716 253 3.35e-02 159 2 1 0.500 0.006 TF:M00940_1 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 1 O00716 253 3.39e-02 161 2 1 0.500 0.006 TF:M07361_1 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 1 1 O00716 253 3.45e-02 95 2 1 0.500 0.011 REAC:157118 rea 1 Signaling by NOTCH 1 O00716 253 3.50e-02 166 2 1 0.500 0.006 TF:M06096_0 tf 1 Factor: ZNF682; motif: KGRGGCGGCTGW; match class: 0 1 O00716 253 3.51e-02 61 2 1 0.500 0.016 KEGG:05212 keg 1 Pancreatic cancer 1 O00716 253 3.53e-02 2059 2 2 1.000 0.001 TF:M04355_0 tf 1 Factor: HOXC12; motif: GYAATAAAA; match class: 0 1 O00716,Q5H9I0 253 3.53e-02 2059 2 2 1.000 0.001 TF:M07377_0 tf 1 Factor: cdx-1; motif: NTTTATKNN; match class: 0 1 O00716,Q5H9I0 253 3.79e-02 180 2 1 0.500 0.006 TF:M04143_0 tf 1 Factor: TEAD3; motif: RCATTCCNNRCATWCCN; match class: 0 1 Q5H9I0 253 3.81e-02 2140 2 2 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 O00716,Q5H9I0 253 3.85e-02 106 2 1 0.500 0.009 REAC:69306 rea 1 DNA Replication 1 O00716 253 3.87e-02 184 2 1 0.500 0.005 TF:M00998_1 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 1 1 Q5H9I0 253 3.97e-02 69 2 1 0.500 0.014 KEGG:05220 keg 1 Chronic myeloid leukemia 1 O00716 253 3.99e-02 2189 2 2 1.000 0.001 TF:M00322_0 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 0 1 O00716,Q5H9I0 253 4.00e-02 4 2 1 0.500 0.250 GO:0070345 BP 1 negative regulation of fat cell proliferation 1 O00716 253 4.34e-02 2282 2 2 1.000 0.001 TF:M04361_0 tf 1 Factor: HOXD12; motif: GTAATAAAA; match class: 0 1 O00716,Q5H9I0 253 4.43e-02 77 2 1 0.500 0.013 KEGG:05215 keg 1 Prostate cancer 1 O00716 253 4.52e-02 2330 2 2 1.000 0.001 TF:M07141_0 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 0 1 O00716,Q5H9I0 253 4.56e-02 217 2 1 0.500 0.005 TF:M06534_0 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 0 1 O00716 253 4.67e-02 2367 2 2 1.000 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 O00716,Q5H9I0 253 4.75e-02 226 2 1 0.500 0.004 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q5H9I0 253 4.83e-02 84 2 1 0.500 0.012 KEGG:05222 keg 1 Small cell lung cancer 1 O00716 253 4.85e-02 2412 2 2 1.000 0.001 TF:M03561_1 tf 1 Factor: POU2F1; motif: NNATTTGCATNN; match class: 1 1 O00716,Q5H9I0 253 5.00e-02 87 2 1 0.500 0.011 KEGG:01522 keg 1 Endocrine resistance 1 O00716 253 5.00e-02 5 2 1 0.500 0.200 GO:0070341 BP 1 fat cell proliferation 1 O00716 253 5.00e-02 138 2 1 0.500 0.007 REAC:2559583 rea 1 Cellular Senescence 1 O00716 253 5.00e-02 138 2 1 0.500 0.007 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 O00716 253 5.00e-02 5 2 1 0.500 0.200 GO:0070344 BP 1 regulation of fat cell proliferation 1 O00716 253 5.00e-02 2450 2 2 1.000 0.001 TF:M00415_0 tf 1 Factor: AREB6; motif: CBGTTTSNN; match class: 0 1 O00716,Q5H9I0 254 2.14e-14 306 29 14 0.483 0.046 GO:0015629 CC 1 actin cytoskeleton 1 Q9P0K7,Q14247,O14639,O75128,Q9ULV4,Q01082,Q5M775,O43707,P28289,Q12792,O94875,Q12965,Q9Y4I1,P59998 254 9.72e-14 195 29 12 0.414 0.062 GO:0003779 MF 1 actin binding 1 O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,Q12792,Q12965,Q0ZGT2,Q13045,P59998 254 2.49e-10 485 29 13 0.448 0.027 GO:0008092 MF 1 cytoskeletal protein binding 1 O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,Q12792,O94875,Q12965,Q0ZGT2,Q13045,P59998 254 1.77e-09 1204 29 17 0.586 0.014 GO:0005856 CC 1 cytoskeleton 1 Q9P0K7,Q14247,O14639,O75128,Q9ULV4,Q01082,Q32MZ4,Q5M775,O43707,P28289,Q12792,O94875,Q12965,P80723,Q13045,Q9Y4I1,P59998 254 1.52e-08 419 29 11 0.379 0.026 GO:0030029 BP 1 actin filament-based process 1 Q14247,O75128,Q9ULV4,Q5M775,O43707,P28289,Q76I76,Q12792,Q12965,Q9Y4I1,P59998 254 1.25e-06 176 29 7 0.241 0.040 GO:0031252 CC 1 cell leading edge 1 Q14247,O14639,O75128,Q9ULV4,Q01082,Q12792,Q9Y4I1 254 1.98e-06 59 29 5 0.172 0.085 GO:0005884 CC 1 actin filament 1 Q14247,O75128,Q5M775,P28289,Q9Y4I1 254 5.15e-06 582 29 10 0.345 0.017 GO:0005912 CC 1 adherens junction 1 Q14247,Q9ULV4,Q01082,Q32MZ4,O43707,Q12792,P98082,Q12965,Q0ZGT2,Q8N556 254 5.63e-06 746 29 11 0.379 0.015 GO:0030054 CC 1 cell junction 1 Q14247,Q9ULV4,Q01082,Q32MZ4,O43707,Q12792,P98082,Q12965,Q0ZGT2,P80723,Q8N556 254 5.93e-06 591 29 10 0.345 0.017 GO:0070161 CC 1 anchoring junction 1 Q14247,Q9ULV4,Q01082,Q32MZ4,O43707,Q12792,P98082,Q12965,Q0ZGT2,Q8N556 254 1.20e-05 358 29 8 0.276 0.022 GO:0030036 BP 1 actin cytoskeleton organization 1 Q14247,O75128,Q9ULV4,Q5M775,P28289,Q76I76,Q12792,P59998 254 1.64e-05 90 29 5 0.172 0.056 GO:0051015 MF 1 actin filament binding 1 Q9ULV4,O43707,Q12965,Q0ZGT2,P59998 254 2.10e-05 42 29 4 0.138 0.095 GO:0097581 BP 1 lamellipodium organization 1 Q14247,O14639,Q9ULV4,Q76I76 254 5.98e-05 117 29 5 0.172 0.043 GO:0008154 BP 1 actin polymerization or depolymerization 1 Q14247,O75128,Q76I76,Q12792,P59998 254 7.06e-05 18 29 3 0.103 0.167 GO:0000146 MF 1 microfilament motor activity 1 Q12965,Q9ULV0,Q9Y4I1 254 7.44e-05 212 29 6 0.207 0.028 GO:0007015 BP 1 actin filament organization 1 Q14247,O75128,P28289,Q76I76,Q12792,P59998 254 8.05e-05 790 29 10 0.345 0.013 GO:0048468 BP 1 cell development 1 Q14247,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,O94875,Q12965,Q0ZGT2 254 8.79e-05 333 29 7 0.241 0.021 GO:0005925 CC 1 focal adhesion 1 Q14247,Q9ULV4,O43707,Q12792,P98082,Q0ZGT2,Q8N556 254 8.79e-05 333 29 7 0.241 0.021 GO:0005924 CC 1 cell-substrate adherens junction 1 Q14247,Q9ULV4,O43707,Q12792,P98082,Q0ZGT2,Q8N556 254 9.50e-05 337 29 7 0.241 0.021 GO:0030055 CC 1 cell-substrate junction 1 Q14247,Q9ULV4,O43707,Q12792,P98082,Q0ZGT2,Q8N556 254 2.27e-04 4 29 2 0.069 0.500 GO:0030050 BP 1 vesicle transport along actin filament 1 O43707,Q9Y4I1 254 2.38e-04 77 29 4 0.138 0.052 GO:0030048 BP 1 actin filament-based movement 1 O43707,P28289,Q12965,Q9Y4I1 254 2.55e-04 1107 29 11 0.379 0.010 GO:0009653 BP 1 anatomical structure morphogenesis 1 Q14247,O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,P80723,Q27J81 254 3.36e-04 84 29 4 0.138 0.048 GO:0001726 CC 1 ruffle 1 Q14247,O75128,Q12792,Q9Y4I1 254 3.42e-04 933 29 10 0.345 0.011 GO:0044430 CC 1 cytoskeletal part 1 Q14247,O14639,O75128,Q01082,Q5M775,P28289,Q12965,Q13045,Q9Y4I1,P59998 254 4.10e-04 758 29 9 0.310 0.012 GO:0007010 BP 1 cytoskeleton organization 1 Q14247,O75128,Q9ULV4,Q5M775,P28289,Q76I76,Q12792,Q0ZGT2,P59998 254 4.92e-04 14 29 3 0.103 0.214 OMIM:603278 omi 1 Focal Segmental Glomerulosclerosis and Nephrotic Syndrome 1 O43707,Q12965,Q27J81 254 5.00e-04 93 29 4 0.138 0.043 GO:0008064 BP 1 regulation of actin polymerization or depolymerization 1 Q14247,Q76I76,Q12792,P59998 254 5.22e-04 94 29 4 0.138 0.043 GO:0030041 BP 1 actin filament polymerization 1 Q14247,O75128,Q12792,P59998 254 5.22e-04 94 29 4 0.138 0.043 GO:0030016 CC 1 myofibril 1 P28289,Q12792,O94875,Q0ZGT2 254 5.22e-04 94 29 4 0.138 0.043 GO:0030832 BP 1 regulation of actin filament length 1 Q14247,Q76I76,Q12792,P59998 254 5.62e-04 1438 29 12 0.414 0.008 GO:0051128 BP 1 regulation of cellular component organization 1 Q14247,O75128,Q9ULV4,Q01082,O43707,Q76I76,Q12792,P98082,Q0ZGT2,Q9Y4I1,Q27J81,P59998 254 5.65e-04 6 29 2 0.069 0.333 GO:0099515 BP 1 actin filament-based transport 1 O43707,Q9Y4I1 254 6.74e-04 314 29 6 0.207 0.019 GO:0000904 BP 1 cell morphogenesis involved in differentiation 1 Q14247,O75128,Q9ULV4,Q01082,O43707,Q76I76 254 6.90e-04 101 29 4 0.138 0.040 GO:0043292 CC 1 contractile fiber 1 P28289,Q12792,O94875,Q0ZGT2 254 9.92e-04 1524 29 12 0.414 0.008 GO:0030154 BP 1 cell differentiation 1 Q14247,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723 254 1.14e-03 115 29 4 0.138 0.035 GO:0005938 CC 1 cell cortex 1 Q14247,O75128,Q01082,Q9ULV0 254 1.17e-03 45 29 3 0.103 0.067 GO:0055002 BP 1 striated muscle cell development 1 P28289,O94875,Q0ZGT2 254 1.35e-03 9 29 2 0.069 0.222 GO:1900025 BP 1 negative regulation of substrate adhesion-dependent cell spreading 1 Q9ULV4,O43707 254 1.39e-03 515 29 7 0.241 0.014 GO:0032989 BP 1 cellular component morphogenesis 1 Q14247,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76 254 1.43e-03 122 29 4 0.138 0.033 GO:0099568 CC 1 cytoplasmic region 1 Q14247,O75128,Q01082,Q9ULV0 254 1.53e-03 523 29 7 0.241 0.013 GO:0022603 BP 1 regulation of anatomical structure morphogenesis 1 Q14247,Q9ULV4,O43707,Q76I76,P98082,P80723,Q27J81 254 1.61e-03 50 29 3 0.103 0.060 GO:0030426 CC 1 growth cone 1 Q14247,O75128,Q9Y4I1 254 1.91e-03 53 29 3 0.103 0.057 GO:0030427 CC 1 site of polarized growth 1 Q14247,O75128,Q9Y4I1 254 1.97e-03 728 29 8 0.276 0.011 GO:0042995 CC 1 cell projection 1 Q14247,O14639,O75128,Q9ULV4,Q01082,O43707,Q12792,Q9Y4I1 254 2.02e-03 54 29 3 0.103 0.056 GO:0055001 BP 1 muscle cell development 1 P28289,O94875,Q0ZGT2 254 2.05e-03 11 29 2 0.069 0.182 GO:0072112 BP 1 glomerular visceral epithelial cell differentiation 1 Q12965,P80723 254 2.05e-03 11 29 2 0.069 0.182 GO:0061318 BP 1 renal filtration cell differentiation 1 Q12965,P80723 254 2.05e-03 11 29 2 0.069 0.182 GO:0072311 BP 1 glomerular epithelial cell differentiation 1 Q12965,P80723 254 2.05e-03 11 29 2 0.069 0.182 GO:0000578 BP 1 embryonic axis specification 1 O75128,P80723 254 2.05e-03 11 29 2 0.069 0.182 GO:0072010 BP 1 glomerular epithelium development 1 Q12965,P80723 254 2.12e-03 1649 29 12 0.414 0.007 GO:0048869 BP 1 cellular developmental process 1 Q14247,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723 254 2.36e-03 139 29 4 0.138 0.029 GO:0010769 BP 1 regulation of cell morphogenesis involved in differentiation 1 Q14247,Q9ULV4,O43707,Q76I76 254 2.45e-03 958 29 9 0.310 0.009 GO:0016192 BP 1 vesicle-mediated transport 1 Q14247,Q9ULV4,Q01082,O43707,P98082,Q12965,Q9ULV0,Q9Y4I1,P59998 254 2.81e-03 1477 29 11 0.379 0.007 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,O94875,Q86V48,Q13045,Q8N556 254 2.89e-03 265 29 5 0.172 0.019 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q14247,Q76I76,Q12792,Q0ZGT2,P59998 254 2.94e-03 266 29 5 0.172 0.019 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 Q14247,O75128,Q5M775,P28289,Q9Y4I1 254 3.14e-03 150 29 4 0.138 0.027 GO:0051258 BP 1 protein polymerization 1 Q14247,O75128,Q12792,P59998 254 3.37e-03 274 29 5 0.172 0.018 GO:0099512 CC 1 supramolecular fiber 1 Q14247,O75128,Q5M775,P28289,Q9Y4I1 254 3.37e-03 274 29 5 0.172 0.018 GO:0099081 CC 1 supramolecular polymer 1 Q14247,O75128,Q5M775,P28289,Q9Y4I1 254 3.79e-03 1016 29 9 0.310 0.009 GO:0006928 BP 1 movement of cell or subcellular component 1 Q14247,Q9ULV4,Q01082,O43707,P28289,P98082,Q12965,Q0ZGT2,Q9Y4I1 254 4.34e-03 70 29 3 0.103 0.043 GO:0044448 CC 1 cell cortex part 1 Q14247,Q01082,Q9ULV0 254 4.43e-03 291 29 5 0.172 0.017 GO:0048858 BP 1 cell projection morphogenesis 1 Q14247,O75128,Q9ULV4,Q01082,Q76I76 254 4.43e-03 2353 29 14 0.483 0.006 GO:0048856 BP 1 anatomical structure development 1 Q14247,O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723,Q27J81 254 4.52e-03 71 29 3 0.103 0.042 GO:0005200 MF 1 structural constituent of cytoskeleton 1 Q01082,O94875,P59998 254 4.64e-03 294 29 5 0.172 0.017 GO:0099080 CC 1 supramolecular complex 1 Q14247,O75128,Q5M775,P28289,Q9Y4I1 254 4.82e-03 168 29 4 0.138 0.024 GO:0048589 BP 1 developmental growth 1 Q14247,O75128,O94875,P80723 254 5.00e-03 299 29 5 0.172 0.017 GO:0032990 BP 1 cell part morphogenesis 1 Q14247,O75128,Q9ULV4,Q01082,Q76I76 254 5.03e-03 17 29 2 0.069 0.118 GO:0009880 BP 1 embryonic pattern specification 1 O75128,P80723 254 5.04e-03 170 29 4 0.138 0.024 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 Q14247,Q76I76,Q12792,P59998 254 5.65e-03 18 29 2 0.069 0.111 GO:0055013 BP 1 cardiac muscle cell development 1 O94875,Q0ZGT2 254 5.73e-03 176 29 4 0.138 0.023 GO:0032535 BP 1 regulation of cellular component size 1 Q14247,Q76I76,Q12792,P59998 254 5.99e-03 1880 29 12 0.414 0.006 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 6.19e-03 1372 29 10 0.345 0.007 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,O43707,P28289,O94875,Q86V48,Q13045,Q8N556 254 6.21e-03 475 29 6 0.207 0.013 GO:0000902 BP 1 cell morphogenesis 1 Q14247,O75128,Q9ULV4,Q01082,O43707,Q76I76 254 6.40e-03 80 29 3 0.103 0.037 GO:0051146 BP 1 striated muscle cell differentiation 1 P28289,O94875,Q0ZGT2 254 6.63e-03 81 29 3 0.103 0.037 GO:0030833 BP 1 regulation of actin filament polymerization 1 Q14247,Q12792,P59998 254 7.00e-03 20 29 2 0.069 0.100 GO:0035282 BP 1 segmentation 1 O75128,P80723 254 7.00e-03 20 29 2 0.069 0.100 GO:0055006 BP 1 cardiac cell development 1 O94875,Q0ZGT2 254 7.00e-03 20 29 2 0.069 0.100 GO:0003785 MF 1 actin monomer binding 1 O75128,Q12792 254 7.06e-03 1396 29 10 0.345 0.007 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,Q9ULV0,Q86V48,Q13045,Q8N556 254 7.12e-03 83 29 3 0.103 0.036 GO:0030017 CC 1 sarcomere 1 P28289,O94875,Q0ZGT2 254 7.65e-03 1933 29 12 0.414 0.006 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 7.72e-03 21 29 2 0.069 0.095 GO:0060419 BP 1 heart growth 1 O94875,P80723 254 7.89e-03 86 29 3 0.103 0.035 GO:0003774 MF 1 motor activity 1 Q12965,Q9ULV0,Q9Y4I1 254 8.07e-03 193 29 4 0.138 0.021 GO:0032970 BP 1 regulation of actin filament-based process 1 Q14247,Q76I76,Q12792,P59998 254 8.09e-03 1179 29 9 0.310 0.008 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 Q14247,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 8.38e-03 195 29 4 0.138 0.021 GO:0007409 BP 1 axonogenesis 1 Q14247,O75128,Q01082,Q76I76 254 8.48e-03 22 29 2 0.069 0.091 GO:0035850 BP 1 epithelial cell differentiation involved in kidney development 1 Q12965,P80723 254 8.66e-03 338 29 5 0.172 0.015 GO:0060284 BP 1 regulation of cell development 1 Q14247,O75128,Q9ULV4,O43707,Q76I76 254 9.00e-03 90 29 3 0.103 0.033 GO:0030027 CC 1 lamellipodium 1 Q14247,O14639,Q9ULV4 254 9.28e-03 23 29 2 0.069 0.087 GO:0061005 BP 1 cell differentiation involved in kidney development 1 Q12965,P80723 254 9.32e-03 707 29 7 0.241 0.010 GO:0033043 BP 1 regulation of organelle organization 1 Q14247,Q76I76,Q12792,Q0ZGT2,Q9Y4I1,Q27J81,P59998 254 9.58e-03 92 29 3 0.103 0.033 GO:0048588 BP 1 developmental cell growth 1 Q14247,O75128,O94875 254 9.85e-03 1990 29 12 0.414 0.006 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 1.05e-02 95 29 3 0.103 0.032 GO:0044449 CC 1 contractile fiber part 1 P28289,O94875,Q0ZGT2 254 1.06e-02 354 29 5 0.172 0.014 GO:0006897 BP 1 endocytosis 1 Q14247,Q9ULV4,P98082,Q12965,P59998 254 1.06e-02 208 29 4 0.138 0.019 GO:0061564 BP 1 axon development 1 Q14247,O75128,Q01082,Q76I76 254 1.10e-02 533 29 5 0.172 0.009 MI:hsa-miR-124 mi 1 MI:hsa-miR-124 1 Q01082,Q32MZ4,O43707,Q27J81,Q9Y2D5 254 1.15e-02 2580 29 14 0.483 0.005 GO:0032502 BP 1 developmental process 1 Q14247,O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723,Q27J81 254 1.18e-02 99 29 3 0.103 0.030 GO:0032271 BP 1 regulation of protein polymerization 1 Q14247,Q12792,P59998 254 1.20e-02 215 29 4 0.138 0.019 GO:0090066 BP 1 regulation of anatomical structure size 1 Q14247,Q76I76,Q12792,P59998 254 1.24e-02 217 29 4 0.138 0.018 GO:0061061 BP 1 muscle structure development 1 P28289,O94875,Q0ZGT2,P80723 254 1.26e-02 596 29 6 0.207 0.010 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q14247,O75128,Q01082,Q9ULV0,Q86V48,Q13045 254 1.27e-02 1 29 1 0.034 1.000 OMIM:614131 omi 1 FOCAL SEGMENTAL GLOMERULOSCLEROSIS 6; FSGS6;;GLOMERULOSCLEROSIS, FOCAL SEGMENTAL, 6 1 Q12965 254 1.27e-02 1 29 1 0.034 1.000 OMIM:214450 omi 1 GRISCELLI SYNDROME, TYPE 1; GS1;;GRISCELLI SYNDROME WITH NEUROLOGIC IMPAIRMENT;;PARTIAL ALBINISM AND PRIMARY NEUROLOGIC DISEASE WITHOUT HEMOPHAGOCYTICSYNDROME;;GRISCELLI SYNDROME, CUTANEOUS AND NEUROLOGIC TYPE 1 Q9Y4I1 254 1.27e-02 1 29 1 0.034 1.000 OMIM:614455 omi 1 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE E; CMTDIE;;CHARCOT-MARIE-TOOTH NEUROPATHY WITH FOCAL SEGMENTAL GLOMERULONEPHRITIS 1 Q27J81 254 1.27e-02 1 29 1 0.034 1.000 OMIM:251850 omi 1 DIARRHEA 2, WITH MICROVILLUS ATROPHY; DIAR2;;MICROVILLUS INCLUSION DISEASE; MVID;;MICROVILLUS ATROPHY, CONGENITAL;;DAVIDSON DISEASE;;CONGENITAL FAMILIAL PROTRACTED DIARRHEA WITH ENTEROCYTE BRUSH-BORDERABNORMALITIES;;INTRACTABLE DIARRHEA OF INFANCY 1 Q9ULV0 254 1.27e-02 1 29 1 0.034 1.000 OMIM:613876 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 20; CMH20 1 Q0ZGT2 254 1.27e-02 1 29 1 0.034 1.000 OMIM:613122 omi 1 CARDIOMYOPATHY, DILATED, 1CC; CMD1CC 1 Q0ZGT2 254 1.27e-02 1 29 1 0.034 1.000 OMIM:613237 omi 1 FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5; FSGS5;;GLOMERULOSCLEROSIS, FOCAL SEGMENTAL, 5 1 Q27J81 254 1.28e-02 369 29 5 0.172 0.014 GO:0050839 MF 1 cell adhesion molecule binding 1 Q14247,Q01082,Q32MZ4,O43707,Q12792 254 1.28e-02 27 29 2 0.069 0.074 GO:0008307 MF 1 structural constituent of muscle 1 O94875,Q0ZGT2 254 1.28e-02 27 29 2 0.069 0.074 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q9ULV4,Q76I76 254 1.32e-02 751 29 7 0.241 0.009 GO:0009888 BP 1 tissue development 1 O75128,Q9ULV4,P98082,O94875,Q12965,Q0ZGT2,P80723 254 1.43e-02 1535 29 10 0.345 0.007 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 1.44e-02 1802 29 11 0.379 0.006 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 1.44e-02 106 29 3 0.103 0.028 GO:0030674 MF 1 protein binding, bridging 1 P98082,O94875,P59998 254 1.47e-02 29 29 2 0.069 0.069 GO:0009798 BP 1 axis specification 1 O75128,P80723 254 1.52e-02 384 29 5 0.172 0.013 GO:0032403 MF 1 protein complex binding 1 Q9ULV4,O43707,Q12965,Q0ZGT2,P59998 254 1.55e-02 1820 29 11 0.379 0.006 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,Q9ULV0,Q86V48,Q13045,Q8N556 254 1.56e-02 1 29 1 0.034 1.000 GO:0007354 BP 1 zygotic determination of anterior/posterior axis, embryo 1 P80723 254 1.56e-02 1 29 1 0.034 1.000 GO:0031289 BP 1 actin phosphorylation 1 Q12792 254 1.56e-02 1 29 1 0.034 1.000 GO:1900042 BP 1 positive regulation of interleukin-2 secretion 1 Q01082 254 1.56e-02 1 29 1 0.034 1.000 GO:0035026 BP 1 leading edge cell differentiation 1 P98082 254 1.56e-02 1 29 1 0.034 1.000 GO:0001757 BP 1 somite specification 1 O75128 254 1.56e-02 1 29 1 0.034 1.000 GO:2001074 BP 1 regulation of metanephric ureteric bud development 1 P80723 254 1.56e-02 1 29 1 0.034 1.000 GO:0043538 BP 1 regulation of actin phosphorylation 1 Q12792 254 1.56e-02 1 29 1 0.034 1.000 GO:0007356 BP 1 thorax and anterior abdomen determination 1 P80723 254 1.56e-02 1 29 1 0.034 1.000 GO:2001076 BP 1 positive regulation of metanephric ureteric bud development 1 P80723 254 1.58e-02 30 29 2 0.069 0.067 GO:0032835 BP 1 glomerulus development 1 Q12965,P80723 254 1.58e-02 30 29 2 0.069 0.067 GO:0005905 CC 1 clathrin-coated pit 1 Q14247,P98082 254 1.68e-02 31 29 2 0.069 0.065 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 Q9ULV4,O43707 254 1.68e-02 31 29 2 0.069 0.065 GO:0055007 BP 1 cardiac muscle cell differentiation 1 O94875,Q0ZGT2 254 1.68e-02 31 29 2 0.069 0.065 GO:0030032 BP 1 lamellipodium assembly 1 O14639,Q76I76 254 1.79e-02 32 29 2 0.069 0.062 GO:0008180 CC 1 COP9 signalosome 1 P28289,P80723 254 1.82e-02 241 29 4 0.138 0.017 GO:0048667 BP 1 cell morphogenesis involved in neuron differentiation 1 Q14247,O75128,Q01082,Q76I76 254 1.88e-02 1091 29 8 0.276 0.007 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q9P0K7,Q14247,Q5M775,O43707,P28289,Q9ULV0,Q86V48,Q13045 254 1.90e-02 1810 29 11 0.379 0.006 GO:0048731 BP 1 system development 1 Q14247,O14639,O75128,Q9ULV4,Q01082,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723 254 1.91e-02 33 29 2 0.069 0.061 GO:1900024 BP 1 regulation of substrate adhesion-dependent cell spreading 1 Q9ULV4,O43707 254 1.99e-02 409 29 5 0.172 0.012 GO:0044463 CC 1 cell projection part 1 Q14247,O75128,Q01082,Q12792,Q9Y4I1 254 2.02e-02 34 29 2 0.069 0.059 GO:0072009 BP 1 nephron epithelium development 1 Q12965,P80723 254 2.02e-02 34 29 2 0.069 0.059 GO:0099518 BP 1 vesicle cytoskeletal trafficking 1 O43707,Q9Y4I1 254 2.04e-02 1885 29 11 0.379 0.006 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,O94875,Q86V48,Q13045,Q8N556 254 2.04e-02 120 29 3 0.103 0.025 GO:0060090 MF 1 binding, bridging 1 P98082,O94875,P59998 254 2.10e-02 1619 29 10 0.345 0.006 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,O43707,P28289,Q9ULV0,Q86V48,Q13045,Q8N556 254 2.13e-02 252 29 4 0.138 0.016 GO:0022604 BP 1 regulation of cell morphogenesis 1 Q14247,Q9ULV4,O43707,Q76I76 254 2.24e-02 420 29 5 0.172 0.012 GO:0005911 CC 1 cell-cell junction 1 Q14247,Q01082,Q32MZ4,Q12792,Q12965 254 2.29e-02 425 29 4 0.138 0.009 MI:hsa-miR-146b-3p mi 1 MI:hsa-miR-146b-3p 1 Q01082,P98082,P80723,P27482 254 2.31e-02 1129 29 8 0.276 0.007 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q14247,O75128,Q01082,Q5M775,Q9ULV0,Q86V48,Q13045,Q8N556 254 2.34e-02 3127 29 15 0.517 0.005 HPA:022020_02 hpa 1 lung; pneumocytes[Uncertain,Medium] 1 Q14247,Q9ULV4,Q01082,Q32MZ4,Q5M775,Q9NQX4,O43707,O94875,Q12965,Q0ZGT2,Q9ULV0,Q86V48,Q13045,Q8N556,Q27J81 254 2.35e-02 126 29 3 0.103 0.024 GO:0060485 BP 1 mesenchyme development 1 Q9ULV4,P98082,P80723 254 2.38e-02 1067 29 8 0.276 0.007 GO:0050793 BP 1 regulation of developmental process 1 Q14247,O75128,Q9ULV4,O43707,Q76I76,P98082,P80723,Q27J81 254 2.39e-02 1924 29 11 0.379 0.006 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 2.39e-02 37 29 2 0.069 0.054 GO:0035265 BP 1 organ growth 1 O94875,P80723 254 2.39e-02 37 29 2 0.069 0.054 GO:0009952 BP 1 anterior/posterior pattern specification 1 O75128,P80723 254 2.43e-02 433 29 4 0.138 0.009 MI:hsa-miR-423-3p mi 1 MI:hsa-miR-423-3p 1 Q9ULV4,P27482,Q8N556,Q9Y2D5 254 2.48e-02 624 29 6 0.207 0.010 GO:0051240 BP 1 positive regulation of multicellular organismal process 1 Q14247,O75128,Q01082,Q32MZ4,P98082,P80723 254 2.59e-02 1403 29 9 0.310 0.006 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,O43707,Q9ULV0,Q86V48,Q13045,Q8N556 254 2.64e-02 2485 29 13 0.448 0.005 GO:0044767 BP 1 single-organism developmental process 1 Q14247,O14639,O75128,Q9ULV4,Q01082,O43707,P28289,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723 254 2.73e-02 2547 29 13 0.448 0.005 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 2.77e-02 271 29 4 0.138 0.015 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q14247,Q01082,Q32MZ4,Q12792 254 2.79e-02 40 29 2 0.069 0.050 GO:0072073 BP 1 kidney epithelium development 1 Q12965,P80723 254 2.80e-02 2194 29 12 0.414 0.005 GO:0070062 CC 1 extracellular exosome 1 Q14247,Q01082,Q9NQX4,O43707,P98082,Q12965,Q9ULV0,Q86V48,P80723,P27482,Q9Y4I1,P59998 254 2.88e-02 274 29 4 0.138 0.015 GO:0048471 CC 1 perinuclear region of cytoplasm 1 O75128,O43707,Q12792,Q27J81 254 2.91e-02 275 29 4 0.138 0.015 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q14247,Q01082,Q32MZ4,Q12792 254 2.92e-02 2205 29 12 0.414 0.005 GO:1903561 CC 1 extracellular vesicle 1 Q14247,Q01082,Q9NQX4,O43707,P98082,Q12965,Q9ULV0,Q86V48,P80723,P27482,Q9Y4I1,P59998 254 2.92e-02 2205 29 12 0.414 0.005 GO:0043230 CC 1 extracellular organelle 1 Q14247,Q01082,Q9NQX4,O43707,P98082,Q12965,Q9ULV0,Q86V48,P80723,P27482,Q9Y4I1,P59998 254 2.99e-02 277 29 4 0.138 0.014 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q14247,Q01082,Q32MZ4,Q12792 254 3.01e-02 2274 29 12 0.414 0.005 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.03e-02 278 29 4 0.138 0.014 GO:0048812 BP 1 neuron projection morphogenesis 1 Q14247,O75128,Q01082,Q76I76 254 3.03e-02 650 29 6 0.207 0.009 GO:0030030 BP 1 cell projection organization 1 Q14247,O14639,O75128,Q9ULV4,Q01082,Q76I76 254 3.05e-02 942 29 7 0.241 0.007 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q9P0K7,Q14247,Q01082,O43707,Q86V48,Q13045,Q8N556 254 3.09e-02 1113 29 8 0.276 0.007 GO:0048513 BP 1 animal organ development 1 O14639,O75128,Q9ULV4,P98082,O94875,Q12965,Q0ZGT2,P80723 254 3.09e-02 139 29 3 0.103 0.022 GO:0042692 BP 1 muscle cell differentiation 1 P28289,O94875,Q0ZGT2 254 3.12e-02 2 29 1 0.034 0.500 GO:0060539 BP 1 diaphragm development 1 P80723 254 3.12e-02 2 29 1 0.034 0.500 GO:0048669 BP 1 collateral sprouting in absence of injury 1 O75128 254 3.12e-02 2 29 1 0.034 0.500 GO:0032417 BP 1 positive regulation of sodium:proton antiporter activity 1 O43707 254 3.12e-02 2 29 1 0.034 0.500 GO:0045179 CC 1 apical cortex 1 Q9ULV0 254 3.12e-02 2 29 1 0.034 0.500 GO:0035502 BP 1 metanephric part of ureteric bud development 1 P80723 254 3.12e-02 2 29 1 0.034 0.500 GO:0030047 BP 1 actin modification 1 Q12792 254 3.12e-02 2 29 1 0.034 0.500 GO:0044294 CC 1 dendritic growth cone 1 O75128 254 3.12e-02 2 29 1 0.034 0.500 GO:0044292 CC 1 dendrite terminus 1 O75128 254 3.14e-02 5761 29 22 0.759 0.004 HPA:019010_01 hpa 1 kidney; cells in glomeruli[Uncertain,Low] 1 Q9P0K7,Q14247,O14639,O75128,Q9ULV4,Q01082,Q32MZ4,Q5M775,Q9NQX4,O43707,Q76I76,Q12792,P98082,O94875,Q12965,Q0ZGT2,Q9ULV0,Q86V48,Q13045,P27482,Q8N556,Q27J81 254 3.14e-02 2286 29 12 0.414 0.005 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.18e-02 1998 29 11 0.379 0.006 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.18e-02 282 29 4 0.138 0.014 GO:0045296 MF 1 cadherin binding 1 Q14247,Q01082,Q32MZ4,Q12792 254 3.21e-02 472 29 4 0.138 0.008 MI:mmu-miR-290-5p mi 1 MI:mmu-miR-290-5p 1 O14639,Q01082,Q5M775,Q13045 254 3.28e-02 50 29 2 0.069 0.040 KEGG:05130 keg 1 Pathogenic Escherichia coli infection 1 Q14247,P59998 254 3.28e-02 142 29 3 0.103 0.021 GO:0072659 BP 1 protein localization to plasma membrane 1 Q01082,P98082,Q9Y4I1 254 3.35e-02 286 29 4 0.138 0.014 GO:0043005 CC 1 neuron projection 1 Q14247,O75128,Q01082,Q9Y4I1 254 3.50e-02 2024 29 11 0.379 0.005 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.51e-02 45 29 2 0.069 0.044 GO:0010771 BP 1 negative regulation of cell morphogenesis involved in differentiation 1 Q9ULV4,O43707 254 3.51e-02 45 29 2 0.069 0.044 GO:0030018 CC 1 Z disc 1 O94875,Q0ZGT2 254 3.51e-02 45 29 2 0.069 0.044 GO:0030175 CC 1 filopodium 1 Q12792,Q9Y4I1 254 3.61e-02 490 29 4 0.138 0.008 MI:hsa-miR-371-5p mi 1 MI:hsa-miR-371-5p 1 O14639,Q01082,Q5M775,Q13045 254 3.61e-02 490 29 4 0.138 0.008 MI:hsa-miR-183 mi 1 MI:hsa-miR-183 1 Q9P0K7,Q01082,A1L390,Q27J81 254 3.66e-02 46 29 2 0.069 0.043 GO:0035051 BP 1 cardiocyte differentiation 1 O94875,Q0ZGT2 254 3.69e-02 294 29 4 0.138 0.014 GO:0005913 CC 1 cell-cell adherens junction 1 Q14247,Q01082,Q32MZ4,Q12792 254 3.70e-02 1756 29 10 0.345 0.006 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.75e-02 2043 29 11 0.379 0.005 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q86V48,Q13045,Q8N556 254 3.81e-02 2342 29 12 0.414 0.005 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P28289,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.82e-02 47 29 2 0.069 0.043 GO:0048041 BP 1 focal adhesion assembly 1 Q14247,Q9ULV4 254 3.82e-02 47 29 2 0.069 0.043 GO:0007045 BP 1 cell-substrate adherens junction assembly 1 Q14247,Q9ULV4 254 3.84e-02 1492 29 9 0.310 0.006 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,Q86V48,Q13045 254 3.85e-02 753 29 6 0.207 0.008 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q14247,Q5M775,P98082,Q9ULV0,Q86V48,Q13045 254 3.89e-02 1769 29 10 0.345 0.006 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.91e-02 2055 29 11 0.379 0.005 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 3.95e-02 7 29 1 0.034 0.143 KEGG:04744 keg 1 Phototransduction 1 P27482 254 3.96e-02 152 29 3 0.103 0.020 GO:1990778 BP 1 protein localization to cell periphery 1 Q01082,P98082,Q9Y4I1 254 3.98e-02 48 29 2 0.069 0.042 GO:1903076 BP 1 regulation of protein localization to plasma membrane 1 Q01082,P98082 254 3.98e-02 48 29 2 0.069 0.042 GO:0033267 CC 1 axon part 1 O75128,Q01082 254 4.03e-02 1242 29 8 0.276 0.006 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q86V48,Q8N556 254 4.12e-02 2366 29 12 0.414 0.005 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 4.13e-02 693 29 6 0.207 0.009 GO:0003008 BP 1 system process 1 Q14247,O14639,P28289,O94875,Q12965,Q9ULV0 254 4.14e-02 1168 29 8 0.276 0.007 GO:1902589 BP 1 single-organism organelle organization 1 Q14247,O75128,Q9ULV4,Q5M775,P28289,Q76I76,Q12792,P59998 254 4.14e-02 49 29 2 0.069 0.041 GO:1904375 BP 1 regulation of protein localization to cell periphery 1 Q01082,P98082 254 4.14e-02 2071 29 11 0.379 0.005 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 4.15e-02 304 29 4 0.138 0.013 GO:0031344 BP 1 regulation of cell projection organization 1 Q14247,O75128,Q9ULV4,Q76I76 254 4.18e-02 155 29 3 0.103 0.019 GO:0098589 CC 1 membrane region 1 Q14247,Q9ULV4,P98082 254 4.20e-02 514 29 4 0.138 0.008 MI:hsa-miR-320 mi 1 MI:hsa-miR-320 1 Q5M775,P98082,Q0ZGT2,Q86V48 254 4.31e-02 50 29 2 0.069 0.040 GO:0030863 CC 1 cortical cytoskeleton 1 Q14247,Q01082 254 4.31e-02 2007 29 11 0.379 0.005 GO:0007275 BP 1 multicellular organism development 1 Q14247,O14639,O75128,Q9ULV4,Q01082,Q76I76,P98082,O94875,Q12965,Q0ZGT2,P80723 254 4.34e-02 700 29 6 0.207 0.009 GO:0045595 BP 1 regulation of cell differentiation 1 Q14247,O75128,Q9ULV4,O43707,Q76I76,P98082 254 4.35e-02 2627 29 13 0.448 0.005 GO:0044421 CC 1 extracellular region part 1 Q14247,Q01082,Q9NQX4,O43707,Q76I76,P98082,Q12965,Q9ULV0,Q86V48,P80723,P27482,Q9Y4I1,P59998 254 4.39e-02 2385 29 12 0.414 0.005 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 4.43e-02 1803 29 10 0.345 0.006 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q86V48,Q13045,Q8N556 254 4.48e-02 51 29 2 0.069 0.039 GO:0072006 BP 1 nephron development 1 Q12965,P80723 254 4.55e-02 707 29 6 0.207 0.008 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q14247,O75128,Q9ULV4,Q01082,P98082,P59998 254 4.65e-02 52 29 2 0.069 0.038 GO:0034333 BP 1 adherens junction assembly 1 Q14247,Q9ULV4 254 4.65e-02 6329 29 23 0.793 0.004 HPA:013010_02 hpa 1 epididymis; glandular cells[Uncertain,Medium] 1 Q9P0K7,Q14247,O14639,O75128,Q9ULV4,Q01082,Q32MZ4,Q5M775,O43707,Q76I76,Q12792,P98082,O94875,Q12965,Q0ZGT2,Q9ULV0,Q86V48,P80723,Q13045,P27482,Q8N556,Q27J81,Q96H55 254 4.67e-02 3 29 1 0.034 0.333 GO:2000096 BP 1 positive regulation of Wnt signaling pathway, planar cell polarity pathway 1 P98082 254 4.67e-02 3 29 1 0.034 0.333 GO:0003301 BP 1 physiological cardiac muscle hypertrophy 1 O94875 254 4.67e-02 3 29 1 0.034 0.333 GO:0032439 BP 1 endosome localization 1 Q9ULV0 254 4.67e-02 3 29 1 0.034 0.333 GO:0061049 BP 1 cell growth involved in cardiac muscle cell development 1 O94875 254 4.67e-02 3 29 1 0.034 0.333 GO:0033504 BP 1 floor plate development 1 O75128 254 4.67e-02 3 29 1 0.034 0.333 GO:0032415 BP 1 regulation of sodium:proton antiporter activity 1 O43707 254 4.67e-02 3 29 1 0.034 0.333 GO:0030903 BP 1 notochord development 1 O75128 254 4.67e-02 3 29 1 0.034 0.333 GO:0003298 BP 1 physiological muscle hypertrophy 1 O94875 254 4.75e-02 2110 29 11 0.379 0.005 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 4.77e-02 536 29 4 0.138 0.007 MI:mmu-miR-693-5p mi 1 MI:mmu-miR-693-5p 1 Q01082,A1L390,Q12965,Q27J81 254 4.82e-02 53 29 2 0.069 0.038 GO:1903729 BP 1 regulation of plasma membrane organization 1 Q01082,P98082 254 4.82e-02 53 29 2 0.069 0.038 GO:0031674 CC 1 I band 1 O94875,Q0ZGT2 254 4.82e-02 504 29 5 0.172 0.010 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q14247,Q9ULV4,Q76I76,Q12792,P59998 254 4.85e-02 62 29 2 0.069 0.032 KEGG:05131 keg 1 Shigellosis 1 Q14247,P59998 254 5.00e-02 2 29 1 0.034 0.500 CORUM:1130 cor 1 Hip1R-cortactin complex 1 Q14247 254 5.00e-02 15 29 3 0.103 0.200 HP:0000097 hp 1 Focal segmental glomerulosclerosis 1 O43707,Q12965,Q27J81 254 5.00e-02 5466 29 23 0.793 0.004 TF:M00470_1 tf 1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 1 Q9P0K7,Q14247,O75128,Q9ULV4,Q01082,Q32MZ4,A1L390,Q5M775,Q9NQX4,O43707,P28289,Q76I76,Q12965,Q9ULV0,Q86V48,P80723,Q13045,P27482,Q8N556,Q9Y4I1,Q27J81,P59998,Q9Y2D5 254 5.00e-02 2425 29 12 0.414 0.005 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q14247,O75128,Q01082,Q5M775,O43707,P98082,O94875,Q9ULV0,Q86V48,Q13045,Q8N556 254 5.00e-02 4 29 1 0.034 0.250 OMIM:606482 omi 1 Autosomal Dominant Intermediate CMT 1 Q27J81 254 5.00e-02 22 29 2 0.069 0.091 REAC:373753 rea 1 Nephrin interactions 1 Q01082,O43707 254 5.00e-02 54 29 2 0.069 0.037 GO:0030838 BP 1 positive regulation of actin filament polymerization 1 Q14247,P59998 255 2.89e-04 86 2 2 1.000 0.023 GO:0046496 BP 1 nicotinamide nucleotide metabolic process 1 Q8N335,P49247 255 2.89e-04 86 2 2 1.000 0.023 GO:0019362 BP 1 pyridine nucleotide metabolic process 1 Q8N335,P49247 255 3.45e-04 94 2 2 1.000 0.021 GO:0006733 BP 1 oxidoreduction coenzyme metabolic process 1 Q8N335,P49247 255 3.68e-04 97 2 2 1.000 0.021 GO:0072524 BP 1 pyridine-containing compound metabolic process 1 Q8N335,P49247 255 9.11e-04 1 2 1 0.500 1.000 GO:0004751 MF 1 ribose-5-phosphate isomerase activity 1 P49247 255 1.26e-03 8 2 1 0.500 0.125 TF:M00078_0 tf 1 Factor: Evi-1; motif: WGAYAAGATAAGATAA; match class: 0 1 P49247 255 1.80e-03 214 2 2 1.000 0.009 GO:0006732 BP 1 coenzyme metabolic process 1 Q8N335,P49247 255 1.82e-03 2 2 1 0.500 0.500 GO:0090038 BP 1 negative regulation of protein kinase C signaling 1 Q8N335 255 1.82e-03 2 2 1 0.500 0.500 GO:0004367 MF 1 glycerol-3-phosphate dehydrogenase [NAD+] activity 1 Q8N335 255 1.82e-03 2 2 1 0.500 0.500 GO:0060373 BP 1 regulation of ventricular cardiac muscle cell membrane depolarization 1 Q8N335 255 2.81e-03 267 2 2 1.000 0.007 GO:0051186 BP 1 cofactor metabolic process 1 Q8N335,P49247 255 4.16e-03 821 2 2 1.000 0.002 TF:M00146_1 tf 1 Factor: HSF1; motif: AGAANRTTCN; match class: 1 1 Q8N335,P49247 255 5.47e-03 6 2 1 0.500 0.167 GO:0090036 BP 1 regulation of protein kinase C signaling 1 Q8N335 255 5.93e-03 388 2 2 1.000 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 Q8N335,P49247 255 6.24e-03 398 2 2 1.000 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 Q8N335,P49247 255 6.38e-03 7 2 1 0.500 0.143 GO:2000010 BP 1 positive regulation of protein localization to cell surface 1 Q8N335 255 6.43e-03 1021 2 2 1.000 0.002 TF:M03566_0 tf 1 Factor: SNA; motif: GCCACCTGNCNGYN; match class: 0 1 Q8N335,P49247 255 6.90e-03 44 2 1 0.500 0.023 TF:M06635_0 tf 1 Factor: znf607; motif: NCCTTGAAGGGM; match class: 0 1 Q8N335 255 7.06e-03 9 2 1 0.500 0.111 REAC:71336 rea 1 Pentose phosphate pathway (hexose monophosphate shunt) 1 P49247 255 7.98e-03 450 2 2 1.000 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 Q8N335,P49247 255 8.94e-03 57 2 1 0.500 0.018 TF:M06605_0 tf 1 Factor: ZNF681; motif: SGGGGTAAAGM; match class: 0 1 P49247 255 9.11e-03 10 2 1 0.500 0.100 GO:0016861 MF 1 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1 P49247 255 1.18e-02 13 2 1 0.500 0.077 GO:0070528 BP 1 protein kinase C signaling 1 Q8N335 255 1.25e-02 1 2 1 0.500 1.000 OMIM:611777 omi 1 BRUGADA SYNDROME 2; BRGDA2 1 Q8N335 255 1.25e-02 1 2 1 0.500 1.000 OMIM:608611 omi 1 RIBOSE 5-PHOSPHATE ISOMERASE DEFICIENCY 1 P49247 255 1.30e-02 1453 2 2 1.000 0.001 TF:M00147_1 tf 1 Factor: HSF2; motif: NGAANNWTCK; match class: 1 1 Q8N335,P49247 255 1.37e-02 15 2 1 0.500 0.067 GO:0006098 BP 1 pentose-phosphate shunt 1 P49247 255 1.46e-02 16 2 1 0.500 0.062 GO:0033137 BP 1 negative regulation of peptidyl-serine phosphorylation 1 Q8N335 255 1.55e-02 17 2 1 0.500 0.059 GO:0051156 BP 1 glucose 6-phosphate metabolic process 1 P49247 255 1.55e-02 17 2 1 0.500 0.059 GO:0086005 BP 1 ventricular cardiac muscle cell action potential 1 Q8N335 255 1.64e-02 18 2 1 0.500 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 Q8N335 255 1.64e-02 18 2 1 0.500 0.056 GO:0017080 MF 1 sodium channel regulator activity 1 Q8N335 255 1.66e-02 106 2 1 0.500 0.009 TF:M05958_0 tf 1 Factor: ZNF286; motif: NTTGGCGGATGM; match class: 0 1 Q8N335 255 1.73e-02 19 2 1 0.500 0.053 GO:0003254 BP 1 regulation of membrane depolarization 1 Q8N335 255 1.75e-02 112 2 1 0.500 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 P49247 255 1.79e-02 674 2 2 1.000 0.003 GO:0019637 BP 1 organophosphate metabolic process 1 Q8N335,P49247 255 1.82e-02 20 2 1 0.500 0.050 GO:0019682 BP 1 glyceraldehyde-3-phosphate metabolic process 1 P49247 255 1.82e-02 20 2 1 0.500 0.050 GO:0010765 BP 1 positive regulation of sodium ion transport 1 Q8N335 255 1.96e-02 25 2 1 0.500 0.040 REAC:1483166 rea 1 Synthesis of PA 1 Q8N335 255 1.99e-02 1798 2 2 1.000 0.001 TF:M00340_1 tf 1 Factor: c-Ets; motif: KRCAGGAARTRNKT; match class: 1 1 Q8N335,P49247 255 2.00e-02 128 2 1 0.500 0.008 TF:M04411_1 tf 1 Factor: NKX2-3; motif: NCCACTTRAN; match class: 1 1 Q8N335 255 2.00e-02 22 2 1 0.500 0.045 GO:0086002 BP 1 cardiac muscle cell action potential involved in contraction 1 Q8N335 255 2.09e-02 23 2 1 0.500 0.043 GO:2000649 BP 1 regulation of sodium ion transmembrane transporter activity 1 Q8N335 255 2.18e-02 24 2 1 0.500 0.042 GO:0006739 BP 1 NADP metabolic process 1 P49247 255 2.19e-02 140 2 1 0.500 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 P49247 255 2.28e-02 25 2 1 0.500 0.040 GO:0006654 BP 1 phosphatidic acid biosynthetic process 1 Q8N335 255 2.28e-02 25 2 1 0.500 0.040 GO:0046473 BP 1 phosphatidic acid metabolic process 1 Q8N335 255 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 P49247 255 2.46e-02 27 2 1 0.500 0.037 GO:0086003 BP 1 cardiac muscle cell contraction 1 Q8N335 255 2.78e-02 178 2 1 0.500 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 Q8N335 255 2.79e-02 179 2 1 0.500 0.006 TF:M05492_0 tf 1 Factor: NKX1-2; motif: WTAATAAGGA; match class: 0 1 P49247 255 2.91e-02 32 2 1 0.500 0.031 GO:1902305 BP 1 regulation of sodium ion transmembrane transport 1 Q8N335 255 2.98e-02 191 2 1 0.500 0.005 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 Q8N335 255 3.00e-02 33 2 1 0.500 0.030 GO:0034394 BP 1 protein localization to cell surface 1 Q8N335 255 3.10e-02 199 2 1 0.500 0.005 TF:M06027_0 tf 1 Factor: ZNF891; motif: NNMACAAGGCAA; match class: 0 1 P49247 255 3.18e-02 35 2 1 0.500 0.029 GO:0019432 BP 1 triglyceride biosynthetic process 1 Q8N335 255 3.18e-02 35 2 1 0.500 0.029 GO:0086001 BP 1 cardiac muscle cell action potential 1 Q8N335 255 3.28e-02 36 2 1 0.500 0.028 GO:0046460 BP 1 neutral lipid biosynthetic process 1 Q8N335 255 3.28e-02 36 2 1 0.500 0.028 GO:0046463 BP 1 acylglycerol biosynthetic process 1 Q8N335 255 3.35e-02 215 2 1 0.500 0.005 TF:M07082_0 tf 1 Factor: DUX4; motif: TAAYYYAATCA; match class: 0 1 P49247 255 3.55e-02 39 2 1 0.500 0.026 GO:0002027 BP 1 regulation of heart rate 1 Q8N335 255 3.73e-02 2459 2 2 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q8N335,P49247 255 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 Q8N335,P49247 255 3.82e-02 42 2 1 0.500 0.024 GO:0016860 MF 1 intramolecular oxidoreductase activity 1 P49247 255 3.82e-02 42 2 1 0.500 0.024 GO:0019674 BP 1 NAD metabolic process 1 Q8N335 255 3.92e-02 252 2 1 0.500 0.004 TF:M01220_0 tf 1 Factor: STAT3:STAT3; motif: TTKMCGGGAAMTSC; match class: 0 1 P49247 255 4.01e-02 258 2 1 0.500 0.004 TF:M06576_0 tf 1 Factor: ZNF419; motif: GGGTGGCCGC; match class: 0 1 Q8N335 255 4.01e-02 258 2 1 0.500 0.004 TF:M06377_0 tf 1 Factor: ZNF773; motif: GGGTGGCCGC; match class: 0 1 Q8N335 255 4.06e-02 2565 2 2 1.000 0.001 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 Q8N335,P49247 255 4.13e-02 2588 2 2 1.000 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 Q8N335,P49247 255 4.18e-02 46 2 1 0.500 0.022 GO:0002028 BP 1 regulation of sodium ion transport 1 Q8N335 255 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q8N335,P49247 255 4.24e-02 2622 2 2 1.000 0.001 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 Q8N335,P49247 255 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 Q8N335 255 4.47e-02 288 2 1 0.500 0.003 TF:M06789_0 tf 1 Factor: ZNF835; motif: NCGRGKGAAMCC; match class: 0 1 P49247 255 4.50e-02 9 2 1 0.500 0.111 HP:0012272 hp 1 J wave 1 Q8N335 255 4.54e-02 292 2 1 0.500 0.003 TF:M05837_0 tf 1 Factor: ZFP2; motif: NCCWCGGGRATA; match class: 0 1 P49247 255 4.54e-02 292 2 1 0.500 0.003 TF:M00687_1 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 1 P49247 255 4.54e-02 292 2 1 0.500 0.003 TF:M07138_0 tf 1 Factor: p63; motif: NNRCAWGYNCARRCWTGYNN; match class: 0 1 Q8N335 255 4.57e-02 294 2 1 0.500 0.003 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 Q8N335 255 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 P49247 255 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q8N335 255 4.97e-02 320 2 1 0.500 0.003 TF:M06344_0 tf 1 Factor: ZNF530; motif: NGGGCAATWAYA; match class: 0 1 P49247 255 5.00e-02 26 2 1 0.500 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 P49247 255 5.00e-02 10 2 1 0.500 0.100 HP:0012232 hp 1 Shortened QT interval 1 Q8N335 255 5.00e-02 55 2 1 0.500 0.018 GO:0051899 BP 1 membrane depolarization 1 Q8N335 255 5.00e-02 10 2 1 0.500 0.100 HP:0011705 hp 1 First degree atrioventricular block 1 Q8N335 255 5.00e-02 64 2 1 0.500 0.016 REAC:75109 rea 1 Triglyceride Biosynthesis 1 Q8N335 255 5.00e-02 4 2 1 0.500 0.250 OMIM:601144 omi 1 Brugada Syndrome 1 Q8N335 256 6.82e-03 3 2 1 0.500 0.333 GO:0043426 MF 1 MRF binding 1 Q9C0J9 256 1.59e-02 7 2 1 0.500 0.143 GO:0010944 BP 1 negative regulation of transcription by competitive promoter binding 1 Q9C0J9 256 2.05e-02 9 2 1 0.500 0.111 GO:0010832 BP 1 negative regulation of myotube differentiation 1 Q9C0J9 256 2.60e-02 141 2 1 0.500 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 Q8TCZ2 256 2.96e-02 13 2 1 0.500 0.077 GO:0051154 BP 1 negative regulation of striated muscle cell differentiation 1 Q9C0J9 256 3.17e-02 38 2 1 0.500 0.026 REAC:1368108 rea 1 BMAL1:CLOCK,NPAS2 activates circadian gene expression 1 Q9C0J9 256 3.41e-02 15 2 1 0.500 0.067 GO:0043425 MF 1 bHLH transcription factor binding 1 Q9C0J9 256 4.09e-02 18 2 1 0.500 0.056 GO:0070888 MF 1 E-box binding 1 Q9C0J9 256 5.00e-02 1 2 1 0.500 1.000 OMIM:612975 omi 1 SHORT SLEEPER;;SHORT SLEEP PHENOTYPE 1 Q9C0J9 256 5.00e-02 60 2 1 0.500 0.017 REAC:400253 rea 1 Circadian Clock 1 Q9C0J9 256 5.00e-02 26 2 1 0.500 0.038 KEGG:04710 keg 1 Circadian rhythm 1 Q9C0J9 256 5.00e-02 22 2 1 0.500 0.045 GO:0010830 BP 1 regulation of myotube differentiation 1 Q9C0J9 257 1.21e-03 2 7 1 0.143 0.500 GO:0019185 CC 1 snRNA-activating protein complex 1 Q16533 257 1.82e-03 3 7 1 0.143 0.333 GO:0097371 MF 1 MDM2/MDM4 family protein binding 1 P61289 257 3.03e-03 5 7 1 0.143 0.200 GO:0061133 MF 1 endopeptidase activator activity 1 P61289 257 3.64e-03 6 7 1 0.143 0.167 GO:0042796 BP 1 snRNA transcription from RNA polymerase III promoter 1 Q16533 257 4.61e-03 1 7 1 0.143 1.000 CORUM:29 cor 1 PA28gamma complex 1 P61289 257 7.26e-03 12 7 1 0.143 0.083 GO:0035102 CC 1 PRC1 complex 1 Q14781 257 7.52e-03 226 7 2 0.286 0.009 GO:0000151 CC 1 ubiquitin ligase complex 1 Q6PCT2,Q14781 257 9.18e-03 2 7 1 0.143 0.500 HP:0008187 hp 1 Absence of secondary sex characteristics 1 Q14781 257 9.18e-03 2 7 1 0.143 0.500 HP:0008668 hp 1 Gonadal dysgenesis, male 1 Q14781 257 1.00e-02 1 7 1 0.143 1.000 OMIM:613080 omi 1 46,XY SEX REVERSAL 5; SRXY5;;46,XY SEX REVERSAL, CBX2-RELATED;;46,XY GONADAL DYSGENESIS, COMPLETE, CBX2-RELATED;;SEX REVERSAL, XY, CBX2-RELATED;;DISORDER OF SEX DEVELOPMENT, 46,XY, CBX2-RELATED 1 Q14781 257 1.09e-02 2 7 1 0.143 0.500 TF:M05794_1 tf 1 Factor: ZNF621; motif: NGGTTCGWCGTA; match class: 1 1 Q9GZU8 257 1.36e-02 307 7 2 0.286 0.007 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 Q6PCT2,P61289 257 1.38e-02 3 7 1 0.143 0.333 HP:0010464 hp 1 Streak ovary 1 Q14781 257 1.51e-02 325 7 2 0.286 0.006 GO:0010498 BP 1 proteasomal protein catabolic process 1 Q6PCT2,P61289 257 1.63e-02 27 7 1 0.143 0.037 GO:0016504 MF 1 peptidase activator activity 1 P61289 257 1.73e-02 339 7 2 0.286 0.006 MI:hsa-miR-26b* mi 1 MI:hsa-miR-26b* 1 P61289,Q14781 257 1.83e-02 4 7 1 0.143 0.250 HP:0008697 hp 1 Hypoplasia of the fallopian tube 1 Q14781 257 1.90e-02 1033 7 3 0.429 0.003 GO:1902494 CC 1 catalytic complex 1 Q6PCT2,P61289,Q14781 257 2.08e-02 360 7 2 0.286 0.006 HPA:021010_03 hpa 1 liver; bile duct cells[Uncertain,High] 1 P61289,Q96C00 257 2.20e-02 384 7 2 0.286 0.005 MI:hsa-miR-186 mi 1 MI:hsa-miR-186 1 Q16533,Q9BUV0 257 2.28e-02 38 7 1 0.143 0.026 GO:0019005 CC 1 SCF ubiquitin ligase complex 1 Q6PCT2 257 2.28e-02 38 7 1 0.143 0.026 GO:0000152 CC 1 nuclear ubiquitin ligase complex 1 Q14781 257 2.29e-02 404 7 2 0.286 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q6PCT2,P61289 257 2.29e-02 5 7 1 0.143 0.200 HP:0008655 hp 1 Aplasia/Hypoplasia of the fallopian tube 1 Q14781 257 2.29e-02 5 7 1 0.143 0.200 HP:0011027 hp 1 Abnormality of the fallopian tube 1 Q14781 257 2.29e-02 5 7 1 0.143 0.200 CORUM:114 cor 1 SNAPc (small nuclear RNA-activating protein) complex 1 Q16533 257 2.32e-02 395 7 2 0.286 0.005 MI:hsa-miR-585 mi 1 MI:hsa-miR-585 1 P61289,Q14781 257 2.33e-02 408 7 2 0.286 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q6PCT2,P61289 257 2.40e-02 40 7 1 0.143 0.025 GO:0006383 BP 1 transcription from RNA polymerase III promoter 1 Q16533 257 2.42e-02 416 7 2 0.286 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q6PCT2,P61289 257 2.58e-02 418 7 2 0.286 0.005 MI:hsa-miR-517b mi 1 MI:hsa-miR-517b 1 Q9BUV0,Q14781 257 2.58e-02 43 7 1 0.143 0.023 GO:0031519 CC 1 PcG protein complex 1 Q14781 257 2.58e-02 43 7 1 0.143 0.023 GO:0045137 BP 1 development of primary sexual characteristics 1 Q14781 257 2.59e-02 27 7 1 0.143 0.037 REAC:76071 rea 1 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1 Q16533 257 2.62e-02 272 7 2 0.286 0.007 REAC:983168 rea 1 Antigen processing: Ubiquitination & Proteasome degradation 1 Q6PCT2,P61289 257 2.65e-02 424 7 2 0.286 0.005 MI:hsa-miR-151-5p mi 1 MI:hsa-miR-151-5p 1 Q9GZU8,Q14781 257 2.74e-02 6 7 1 0.143 0.167 HP:0010462 hp 1 Aplasia/Hypoplasia of the ovary 1 Q14781 257 2.74e-02 6 7 1 0.143 0.167 HP:0008724 hp 1 Hypoplasia of the ovary 1 Q14781 257 2.74e-02 6 7 1 0.143 0.167 HP:0005092 hp 1 Streaky metaphyseal sclerosis 1 Q14781 257 2.91e-02 459 7 2 0.286 0.004 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q6PCT2,P61289 257 2.92e-02 447 7 2 0.286 0.004 MI:hsa-miR-18b mi 1 MI:hsa-miR-18b 1 Q9BUV0,Q14781 257 3.00e-02 50 7 1 0.143 0.020 GO:0002039 MF 1 p53 binding 1 P61289 257 3.05e-02 594 7 3 0.429 0.005 TF:M00935_1 tf 1 Factor: NF-AT; motif: NWGGAAANWN; match class: 1 1 Q16533,Q14781,Q96C00 257 3.17e-02 53 7 1 0.143 0.019 GO:0000502 CC 1 proteasome complex 1 P61289 257 3.17e-02 53 7 1 0.143 0.019 GO:1905369 CC 1 endopeptidase complex 1 P61289 257 3.17e-02 53 7 1 0.143 0.019 GO:0006521 BP 1 regulation of cellular amino acid metabolic process 1 P61289 257 3.20e-02 469 7 2 0.286 0.004 MI:hsa-miR-26a mi 1 MI:hsa-miR-26a 1 Q6PCT2,Q9BUV0 257 3.20e-02 7 7 1 0.143 0.143 HP:0001470 hp 1 Sex-limited autosomal dominant 1 Q14781 257 3.21e-02 484 7 2 0.286 0.004 GO:0044257 BP 1 cellular protein catabolic process 1 Q6PCT2,P61289 257 3.21e-02 470 7 2 0.286 0.004 MI:hsa-miR-18a mi 1 MI:hsa-miR-18a 1 Q9BUV0,Q14781 257 3.25e-02 34 7 1 0.143 0.029 REAC:76046 rea 1 RNA Polymerase III Transcription Initiation 1 Q16533 257 3.29e-02 55 7 1 0.143 0.018 GO:0002479 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 1 P61289 257 3.35e-02 56 7 1 0.143 0.018 GO:0033238 BP 1 regulation of cellular amine metabolic process 1 P61289 257 3.41e-02 57 7 1 0.143 0.018 GO:0042590 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class I 1 P61289 257 3.53e-02 37 7 1 0.143 0.027 REAC:749476 rea 1 RNA Polymerase III Abortive And Retractive Initiation 1 Q16533 257 3.53e-02 37 7 1 0.143 0.027 REAC:74158 rea 1 RNA Polymerase III Transcription 1 Q16533 257 3.58e-02 322 7 2 0.286 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q6PCT2,P61289 257 3.59e-02 60 7 1 0.143 0.017 GO:2001237 BP 1 negative regulation of extrinsic apoptotic signaling pathway 1 P61289 257 3.59e-02 60 7 1 0.143 0.017 GO:0007548 BP 1 sex differentiation 1 Q14781 257 3.65e-02 8 7 1 0.143 0.125 HP:0000150 hp 1 Gonadoblastoma 1 Q14781 257 3.73e-02 510 7 2 0.286 0.004 MI:hsa-miR-338-5p mi 1 MI:hsa-miR-338-5p 1 Q9BUV0,Q9GZU8 257 3.81e-02 7 7 1 0.143 0.143 TF:M06504_1 tf 1 Factor: ZFP62; motif: TNGAAWACCKC; match class: 1 1 Q9GZU8 257 4.01e-02 530 7 2 0.286 0.004 MI:hsa-let-7f-2* mi 1 MI:hsa-let-7f-2* 1 Q9BUV0,Q14781 257 4.06e-02 68 7 1 0.143 0.015 GO:1905368 CC 1 peptidase complex 1 P61289 257 4.06e-02 68 7 1 0.143 0.015 GO:0051436 BP 1 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1 P61289 257 4.11e-02 69 7 1 0.143 0.014 GO:0051439 BP 1 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1 P61289 257 4.11e-02 69 7 1 0.143 0.014 GO:1904667 BP 1 negative regulation of ubiquitin protein ligase activity 1 P61289 257 4.17e-02 70 7 1 0.143 0.014 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 Q16533 257 4.17e-02 70 7 1 0.143 0.014 GO:0009301 BP 1 snRNA transcription 1 Q16533 257 4.20e-02 560 7 2 0.286 0.004 GO:0030163 BP 1 protein catabolic process 1 Q6PCT2,P61289 257 4.28e-02 45 7 1 0.143 0.022 REAC:4570464 rea 1 SUMOylation of RNA binding proteins 1 Q14781 257 4.38e-02 573 7 2 0.286 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 P61289,Q14781 257 4.41e-02 74 7 1 0.143 0.014 GO:0051437 BP 1 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition 1 P61289 257 4.41e-02 74 7 1 0.143 0.014 GO:0051444 BP 1 negative regulation of ubiquitin-protein transferase activity 1 P61289 257 4.47e-02 47 7 1 0.143 0.021 REAC:1236978 rea 1 Cross-presentation of soluble exogenous antigens (endosomes) 1 P61289 257 4.52e-02 76 7 1 0.143 0.013 GO:0002474 BP 1 antigen processing and presentation of peptide antigen via MHC class I 1 P61289 257 4.55e-02 10 7 1 0.143 0.100 HP:0012244 hp 1 Abnormal sex determination 1 Q14781 257 4.55e-02 10 7 1 0.143 0.100 HP:0100621 hp 1 Dysgerminoma 1 Q14781 257 4.55e-02 10 7 1 0.143 0.100 HP:0100620 hp 1 Germinoma 1 Q14781 257 4.55e-02 10 7 1 0.143 0.100 HP:0012245 hp 1 Sex reversal 1 Q14781 257 4.58e-02 77 7 1 0.143 0.013 GO:0031145 BP 1 anaphase-promoting complex-dependent catabolic process 1 P61289 257 4.58e-02 77 7 1 0.143 0.013 GO:1904668 BP 1 positive regulation of ubiquitin protein ligase activity 1 P61289 257 4.65e-02 49 7 1 0.143 0.020 REAC:211733 rea 1 Regulation of activated PAK-2p34 by proteasome mediated degradation 1 P61289 257 4.70e-02 79 7 1 0.143 0.013 GO:1904666 BP 1 regulation of ubiquitin protein ligase activity 1 P61289 257 4.75e-02 50 7 1 0.143 0.020 REAC:180534 rea 1 Vpu mediated degradation of CD4 1 P61289 257 4.75e-02 50 7 1 0.143 0.020 REAC:69017 rea 1 CDK-mediated phosphorylation and removal of Cdc6 1 P61289 257 4.75e-02 50 7 1 0.143 0.020 REAC:75815 rea 1 Ubiquitin-dependent degradation of Cyclin D 1 P61289 257 4.75e-02 50 7 1 0.143 0.020 REAC:69229 rea 1 Ubiquitin-dependent degradation of Cyclin D1 1 P61289 257 4.75e-02 50 7 1 0.143 0.020 REAC:350562 rea 1 Regulation of ornithine decarboxylase (ODC) 1 P61289 257 4.81e-02 378 7 2 0.286 0.005 REAC:2262752 rea 1 Cellular responses to stress 1 P61289,Q14781 257 4.84e-02 51 7 1 0.143 0.020 REAC:349425 rea 1 Autodegradation of the E3 ubiquitin ligase COP1 1 P61289 257 4.88e-02 590 7 2 0.286 0.003 MI:mmu-miR-466h mi 1 MI:mmu-miR-466h 1 Q9BUV0,P61289 257 4.93e-02 83 7 1 0.143 0.012 GO:2000060 BP 1 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 P61289 257 4.93e-02 83 7 1 0.143 0.012 GO:2001236 BP 1 regulation of extrinsic apoptotic signaling pathway 1 P61289 257 4.93e-02 52 7 1 0.143 0.019 REAC:69610 rea 1 p53-Independent DNA Damage Response 1 P61289 257 4.93e-02 52 7 1 0.143 0.019 REAC:69601 rea 1 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1 P61289 257 4.93e-02 52 7 1 0.143 0.019 REAC:180585 rea 1 Vif-mediated degradation of APOBEC3G 1 P61289 257 4.93e-02 52 7 1 0.143 0.019 REAC:69613 rea 1 p53-Independent G1/S DNA damage checkpoint 1 P61289 257 4.99e-02 84 7 1 0.143 0.012 GO:0044106 BP 1 cellular amine metabolic process 1 P61289 257 4.99e-02 84 7 1 0.143 0.012 GO:0016073 BP 1 snRNA metabolic process 1 Q16533 257 5.00e-02 1503 7 4 0.571 0.003 TF:M00976_0 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 0 1 Q16533,Q6PCT2,Q9BUV0,Q14781 257 5.00e-02 11 7 1 0.143 0.091 HP:0004979 hp 1 Metaphyseal sclerosis 1 Q14781 257 5.00e-02 11 7 1 0.143 0.091 HP:0000041 hp 1 Chordee 1 Q14781 257 5.00e-02 11 7 1 0.143 0.091 CORUM:115 cor 1 Polycomb repressive complex 1 (PRC1, hPRC-H) 1 Q14781 257 5.00e-02 5 7 1 0.143 0.200 OMIM:400044 omi 1 46,XY Sex Reversal 1 Q14781 258 8.25e-03 1883 3 3 1.000 0.002 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.08e-02 2060 3 3 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.10e-02 2072 3 3 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.21e-02 2139 3 3 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.25e-02 2 3 1 0.333 0.500 TF:M06885_0 tf 1 Factor: ZNF545; motif: GGGGGARTTRGGGTCWGY; match class: 0 1 Q9UMX0 258 1.32e-02 2202 3 3 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P52758,Q9UMX0,O95202 258 1.45e-02 2274 3 3 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.48e-02 2290 3 3 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.70e-02 2395 3 3 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.76e-02 2425 3 3 1.000 0.001 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 1.87e-02 2472 3 3 1.000 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 2.04e-02 2547 3 3 1.000 0.001 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 P52758,Q9UMX0,O95202 258 2.15e-02 3 3 1 0.333 0.333 HP:0004484 hp 1 Craniofacial asymmetry 1 O95202 258 2.15e-02 3 3 1 0.333 0.333 HP:0004794 hp 1 Malrotation of small bowel 1 O95202 258 2.15e-02 3 3 1 0.333 0.333 HP:0006655 hp 1 Rib segmentation abnormalities 1 O95202 258 2.86e-02 4 3 1 0.333 0.250 HP:0002057 hp 1 Prominent glabella 1 O95202 258 2.86e-02 4 3 1 0.333 0.250 HP:0002056 hp 1 Abnormality of the glabella 1 O95202 258 2.86e-02 4 3 1 0.333 0.250 HP:0001812 hp 1 Hyperconvex fingernails 1 O95202 258 3.10e-02 906 3 2 0.667 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q9UMX0,O95202 258 3.49e-02 3045 3 3 1.000 0.001 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 3.57e-02 5 3 1 0.333 0.200 HP:0000188 hp 1 Short upper lip 1 O95202 258 3.57e-02 5 3 1 0.333 0.200 HP:0007109 hp 1 Periventricular cysts 1 O95202 258 3.72e-02 995 3 2 0.667 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 Q9UMX0,O95202 258 4.08e-02 3208 3 3 1.000 0.001 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.23e-02 3247 3 3 1.000 0.001 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.29e-02 6 3 1 0.333 0.167 HP:0009193 hp 1 Pseudoepiphyses of the metacarpals 1 O95202 258 4.29e-02 6 3 1 0.333 0.167 HP:0000558 hp 1 Rieger anomaly 1 O95202 258 4.29e-02 6 3 1 0.333 0.167 HP:0009918 hp 1 Ectopia pupillae 1 O95202 258 4.29e-02 6 3 1 0.333 0.167 HP:0002144 hp 1 Tethered cord 1 O95202 258 4.34e-02 1078 3 2 0.667 0.002 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q9UMX0,O95202 258 4.55e-02 3326 3 3 1.000 0.001 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.55e-02 3326 3 3 1.000 0.001 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.57e-02 1107 3 2 0.667 0.002 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q9UMX0,O95202 258 4.58e-02 3334 3 3 1.000 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.63e-02 3344 3 3 1.000 0.001 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.63e-02 3344 3 3 1.000 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.67e-02 3355 3 3 1.000 0.001 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.68e-02 1121 3 2 0.667 0.002 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 Q9UMX0,O95202 258 4.70e-02 3361 3 3 1.000 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.73e-02 3368 3 3 1.000 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.73e-02 3370 3 3 1.000 0.001 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.77e-02 3379 3 3 1.000 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.78e-02 1133 3 2 0.667 0.002 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q9UMX0,O95202 258 4.80e-02 3386 3 3 1.000 0.001 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.80e-02 3386 3 3 1.000 0.001 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.80e-02 3386 3 3 1.000 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.82e-02 3390 3 3 1.000 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.87e-02 3403 3 3 1.000 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.88e-02 3405 3 3 1.000 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.89e-02 3407 3 3 1.000 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.89e-02 3407 3 3 1.000 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.91e-02 3412 3 3 1.000 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.92e-02 3413 3 3 1.000 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.93e-02 3415 3 3 1.000 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.93e-02 3416 3 3 1.000 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.93e-02 3416 3 3 1.000 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.93e-02 3416 3 3 1.000 0.001 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.94e-02 3418 3 3 1.000 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.95e-02 3420 3 3 1.000 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.95e-02 3421 3 3 1.000 0.001 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.96e-02 3422 3 3 1.000 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.96e-02 3422 3 3 1.000 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.96e-02 3423 3 3 1.000 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.96e-02 3423 3 3 1.000 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.97e-02 3424 3 3 1.000 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.97e-02 3426 3 3 1.000 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.97e-02 3426 3 3 1.000 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.98e-02 3428 3 3 1.000 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.99e-02 3429 3 3 1.000 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.99e-02 3429 3 3 1.000 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.99e-02 3429 3 3 1.000 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 4.99e-02 3430 3 3 1.000 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3431 3 3 1.000 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3432 3 3 1.000 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3432 3 3 1.000 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 8 3 1 0.333 0.125 TF:M04066_1 tf 1 Factor: PAX7; motif: TAATCGATTA; match class: 1 1 Q9UMX0 258 5.00e-02 1 3 1 0.333 1.000 GO:1901340 BP 1 negative regulation of store-operated calcium channel activity 1 Q9UMX0 258 5.00e-02 3432 3 3 1.000 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 3432 3 3 1.000 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 8 3 1 0.333 0.125 TF:M04062_0 tf 1 Factor: PAX3; motif: TAATYRATTA; match class: 0 1 Q9UMX0 258 5.00e-02 3432 3 3 1.000 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 8 3 1 0.333 0.125 TF:M04066_0 tf 1 Factor: PAX7; motif: TAATCGATTA; match class: 0 1 Q9UMX0 258 5.00e-02 7 3 1 0.333 0.143 HP:0003363 hp 1 Abdominal situs inversus 1 O95202 258 5.00e-02 7 3 1 0.333 0.143 HP:0030853 hp 1 Heterotaxy 1 O95202 258 5.00e-02 3432 3 3 1.000 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 258 5.00e-02 7 3 1 0.333 0.143 HP:0011620 hp 1 Abnormality of abdominal situs 1 O95202 258 5.00e-02 8 3 1 0.333 0.125 TF:M04062_1 tf 1 Factor: PAX3; motif: TAATYRATTA; match class: 1 1 Q9UMX0 258 5.00e-02 7 3 1 0.333 0.143 HP:0005913 hp 1 Abnormality of metacarpal epiphyses 1 O95202 258 5.00e-02 6 3 1 0.333 0.167 CORUM:5209 cor 1 Ubiquilin-proteasome complex 1 Q9UMX0 258 5.00e-02 3432 3 3 1.000 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P52758,Q9UMX0,O95202 259 3.54e-05 22 3 2 0.667 0.091 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 Q13303,Q14722 259 4.23e-05 24 3 2 0.667 0.083 GO:0015459 MF 1 potassium channel regulator activity 1 Q13303,Q14722 259 9.11e-05 35 3 2 0.667 0.057 GO:1901379 BP 1 regulation of potassium ion transmembrane transport 1 Q13303,Q14722 259 1.32e-04 42 3 2 0.667 0.048 GO:0043266 BP 1 regulation of potassium ion transport 1 Q13303,Q14722 259 1.80e-04 49 3 2 0.667 0.041 GO:0034705 CC 1 potassium channel complex 1 Q13303,Q14722 259 2.44e-04 57 3 2 0.667 0.035 GO:0099106 MF 1 ion channel regulator activity 1 Q13303,Q14722 259 3.90e-04 72 3 2 0.667 0.028 GO:0031234 CC 1 extrinsic component of cytoplasmic side of plasma membrane 1 Q13303,Q14722 259 4.01e-04 73 3 2 0.667 0.027 GO:0071805 BP 1 potassium ion transmembrane transport 1 Q13303,Q14722 259 4.01e-04 73 3 2 0.667 0.027 GO:0071804 BP 1 cellular potassium ion transport 1 Q13303,Q14722 259 4.35e-04 76 3 2 0.667 0.026 GO:0016247 MF 1 channel regulator activity 1 Q13303,Q14722 259 6.10e-04 28 3 2 0.667 0.071 REAC:1296072 rea 1 Voltage gated Potassium channels 1 Q13303,Q14722 259 6.11e-04 90 3 2 0.667 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Q13303,Q14722 259 6.96e-04 96 3 2 0.667 0.021 GO:0006813 BP 1 potassium ion transport 1 Q13303,Q14722 259 7.25e-04 98 3 2 0.667 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 Q13303,Q14722 259 7.25e-04 98 3 2 0.667 0.020 GO:0019897 CC 1 extrinsic component of plasma membrane 1 Q13303,Q14722 259 8.84e-04 1 3 1 0.333 1.000 GO:1990031 CC 1 pinceau fiber 1 Q13303 259 8.97e-04 109 3 2 0.667 0.018 GO:0034703 CC 1 cation channel complex 1 Q13303,Q14722 259 9.64e-04 113 3 2 0.667 0.018 GO:1904062 BP 1 regulation of cation transmembrane transport 1 Q13303,Q14722 259 1.07e-03 119 3 2 0.667 0.017 GO:0009898 CC 1 cytoplasmic side of plasma membrane 1 Q13303,Q14722 259 1.30e-03 131 3 2 0.667 0.015 GO:0098562 CC 1 cytoplasmic side of membrane 1 Q13303,Q14722 259 1.40e-03 136 3 2 0.667 0.015 GO:0034702 CC 1 ion channel complex 1 Q13303,Q14722 259 1.40e-03 136 3 2 0.667 0.015 GO:0034765 BP 1 regulation of ion transmembrane transport 1 Q13303,Q14722 259 1.54e-03 143 3 2 0.667 0.014 GO:0034762 BP 1 regulation of transmembrane transport 1 Q13303,Q14722 259 1.59e-03 145 3 2 0.667 0.014 GO:0010959 BP 1 regulation of metal ion transport 1 Q13303,Q14722 259 2.01e-03 163 3 2 0.667 0.012 GO:1902495 CC 1 transmembrane transporter complex 1 Q13303,Q14722 259 2.13e-03 168 3 2 0.667 0.012 GO:1990351 CC 1 transporter complex 1 Q13303,Q14722 259 2.34e-03 176 3 2 0.667 0.011 GO:0019898 CC 1 extrinsic component of membrane 1 Q13303,Q14722 259 2.65e-03 3 3 1 0.333 0.333 GO:0070995 BP 1 NADPH oxidation 1 Q13303 259 2.95e-03 61 3 2 0.667 0.033 REAC:1296071 rea 1 Potassium Channels 1 Q13303,Q14722 259 3.05e-03 201 3 2 0.667 0.010 GO:0015672 BP 1 monovalent inorganic cation transport 1 Q13303,Q14722 259 3.33e-03 210 3 2 0.667 0.010 GO:0043269 BP 1 regulation of ion transport 1 Q13303,Q14722 259 3.48e-03 215 3 2 0.667 0.009 GO:0098552 CC 1 side of membrane 1 Q13303,Q14722 259 4.34e-03 240 3 2 0.667 0.008 GO:0098662 BP 1 inorganic cation transmembrane transport 1 Q13303,Q14722 259 4.86e-03 254 3 2 0.667 0.008 GO:0098655 BP 1 cation transmembrane transport 1 Q13303,Q14722 259 5.44e-03 269 3 2 0.667 0.007 GO:0098660 BP 1 inorganic ion transmembrane transport 1 Q13303,Q14722 259 5.76e-03 1670 3 3 1.000 0.002 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q13303,P48147,Q14722 259 7.07e-03 8 3 1 0.333 0.125 GO:0044224 CC 1 juxtaparanode region of axon 1 Q13303 259 7.19e-03 3 3 1 0.333 0.333 HP:0006897 hp 1 Cranial nerve VI palsy 1 Q13303 259 7.95e-03 9 3 1 0.333 0.111 GO:1902259 BP 1 regulation of delayed rectifier potassium channel activity 1 Q14722 259 8.84e-03 10 3 1 0.333 0.100 GO:0070402 MF 1 NADPH binding 1 Q14722 259 8.96e-03 217 3 2 0.667 0.009 TF:M00141_1 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 1 1 P48147,Q14722 259 8.97e-03 346 3 2 0.667 0.006 GO:0030001 BP 1 metal ion transport 1 Q13303,Q14722 259 9.58e-03 4 3 1 0.333 0.250 HP:0010316 hp 1 Ebstein's anomaly of the tricuspid valve 1 Q13303 259 1.05e-02 375 3 2 0.667 0.005 GO:0055114 BP 1 oxidation-reduction process 1 Q13303,Q14722 259 1.06e-02 2049 3 3 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.13e-02 2092 3 3 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q13303,P48147,Q14722 259 1.20e-02 5 3 1 0.333 0.200 HP:0010865 hp 1 Oppositional defiant disorder 1 Q13303 259 1.24e-02 2154 3 3 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.29e-02 2183 3 3 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q13303,P48147,Q14722 259 1.29e-02 416 3 2 0.667 0.005 GO:0034220 BP 1 ion transmembrane transport 1 Q13303,Q14722 259 1.44e-02 6 3 1 0.333 0.167 HP:0001734 hp 1 Annular pancreas 1 Q13303 259 1.44e-02 440 3 2 0.667 0.005 GO:0006812 BP 1 cation transport 1 Q13303,Q14722 259 1.46e-02 2279 3 3 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.47e-02 2281 3 3 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.48e-02 2290 3 3 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.59e-02 18 3 1 0.333 0.056 GO:2000008 BP 1 regulation of protein localization to cell surface 1 Q13303 259 1.68e-02 7 3 1 0.333 0.143 HP:0000892 hp 1 Bifid ribs 1 Q13303 259 1.68e-02 2385 3 3 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.70e-02 2397 3 3 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.71e-02 480 3 2 0.667 0.004 GO:0016491 MF 1 oxidoreductase activity 1 Q13303,Q14722 259 1.75e-02 2417 3 3 1.000 0.001 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.77e-02 2429 3 3 1.000 0.001 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.83e-02 2456 3 3 1.000 0.001 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.86e-02 2469 3 3 1.000 0.001 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.87e-02 2472 3 3 1.000 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.91e-02 8 3 1 0.333 0.125 HP:0010722 hp 1 Asymmetry of the ears 1 Q13303 259 1.92e-02 2495 3 3 1.000 0.001 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.92e-02 2496 3 3 1.000 0.001 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 Q13303,P48147,Q14722 259 1.97e-02 8 3 1 0.333 0.125 TF:M06540_0 tf 1 Factor: znf540; motif: NTGTCCATATTC; match class: 0 1 Q14722 259 2.08e-02 529 3 2 0.667 0.004 GO:0055085 BP 1 transmembrane transport 1 Q13303,Q14722 259 2.12e-02 24 3 1 0.333 0.042 GO:0044304 CC 1 main axon 1 Q13303 259 2.12e-02 24 3 1 0.333 0.042 GO:0006739 BP 1 NADP metabolic process 1 Q13303 259 2.21e-02 25 3 1 0.333 0.040 GO:0050661 MF 1 NADP binding 1 Q14722 259 2.29e-02 26 3 1 0.333 0.038 GO:1901016 BP 1 regulation of potassium ion transmembrane transporter activity 1 Q14722 259 2.42e-02 798 3 2 0.667 0.003 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P48147,Q14722 259 2.63e-02 11 3 1 0.333 0.091 HP:0002188 hp 1 Delayed CNS myelination 1 Q13303 259 2.63e-02 11 3 1 0.333 0.091 HP:0002616 hp 1 Aortic root dilatation 1 Q13303 259 2.91e-02 33 3 1 0.333 0.030 GO:0034394 BP 1 protein localization to cell surface 1 Q13303 259 2.95e-02 12 3 1 0.333 0.083 TF:M06653_0 tf 1 Factor: ZFP3; motif: KGGTAATAAAGC; match class: 0 1 Q14722 259 3.06e-02 2914 3 3 1.000 0.001 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 3.58e-02 15 3 1 0.333 0.067 HP:0012817 hp 1 Noncompaction cardiomyopathy 1 Q13303 259 3.58e-02 15 3 1 0.333 0.067 HP:0000176 hp 1 Submucous cleft hard palate 1 Q13303 259 3.58e-02 15 3 1 0.333 0.067 HP:0011228 hp 1 Horizontal eyebrow 1 Q13303 259 3.58e-02 15 3 1 0.333 0.067 HP:0410005 hp 1 Cleft hard palate 1 Q13303 259 3.82e-02 16 3 1 0.333 0.062 HP:0000902 hp 1 Rib fusion 1 Q13303 259 3.82e-02 16 3 1 0.333 0.062 HP:0000851 hp 1 Congenital hypothyroidism 1 Q13303 259 3.94e-02 733 3 2 0.667 0.003 GO:0006811 BP 1 ion transport 1 Q13303,Q14722 259 4.05e-02 17 3 1 0.333 0.059 HP:0100559 hp 1 Lower limb asymmetry 1 Q13303 259 4.08e-02 3208 3 3 1.000 0.001 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.18e-02 17 3 1 0.333 0.059 TF:M05718_0 tf 1 Factor: ZNF30; motif: NGGTTAAGAYRC; match class: 0 1 Q14722 259 4.23e-02 48 3 1 0.333 0.021 GO:0033267 CC 1 axon part 1 Q13303 259 4.23e-02 48 3 1 0.333 0.021 GO:0008076 CC 1 voltage-gated potassium channel complex 1 Q13303 259 4.23e-02 3247 3 3 1.000 0.001 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.29e-02 18 3 1 0.333 0.056 HP:0001655 hp 1 Patent foramen ovale 1 Q13303 259 4.29e-02 18 3 1 0.333 0.056 HP:0006956 hp 1 Dilation of lateral ventricles 1 Q13303 259 4.42e-02 18 3 1 0.333 0.056 TF:M06167_0 tf 1 Factor: ZNF93; motif: NGGGGAAGAAKA; match class: 0 1 Q13303 259 4.53e-02 19 3 1 0.333 0.053 HP:0002101 hp 1 Abnormal lung lobation 1 Q13303 259 4.55e-02 3326 3 3 1.000 0.001 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.55e-02 3326 3 3 1.000 0.001 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.58e-02 3334 3 3 1.000 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.63e-02 3344 3 3 1.000 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.67e-02 3355 3 3 1.000 0.001 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.70e-02 3361 3 3 1.000 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.73e-02 3368 3 3 1.000 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.76e-02 20 3 1 0.333 0.050 HP:0001107 hp 1 Ocular albinism 1 Q13303 259 4.76e-02 20 3 1 0.333 0.050 HP:0410004 hp 1 Cleft secondary palate 1 Q13303 259 4.77e-02 3379 3 3 1.000 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.80e-02 1135 3 2 0.667 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P48147,Q14722 259 4.80e-02 3386 3 3 1.000 0.001 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.80e-02 3386 3 3 1.000 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.82e-02 3390 3 3 1.000 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.84e-02 55 3 1 0.333 0.018 GO:2001257 BP 1 regulation of cation channel activity 1 Q14722 259 4.87e-02 3403 3 3 1.000 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.88e-02 3405 3 3 1.000 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.89e-02 3407 3 3 1.000 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.89e-02 3407 3 3 1.000 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.91e-02 3412 3 3 1.000 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.91e-02 20 3 1 0.333 0.050 TF:M00248_0 tf 1 Factor: Oct-1; motif: TNTATGBTAATT; match class: 0 1 Q13303 259 4.92e-02 3413 3 3 1.000 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.93e-02 3415 3 3 1.000 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.93e-02 3416 3 3 1.000 0.001 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.93e-02 3416 3 3 1.000 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.93e-02 3416 3 3 1.000 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.94e-02 3418 3 3 1.000 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.95e-02 3420 3 3 1.000 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.96e-02 3422 3 3 1.000 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.96e-02 3422 3 3 1.000 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.96e-02 3423 3 3 1.000 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.96e-02 3423 3 3 1.000 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.97e-02 3424 3 3 1.000 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.97e-02 3426 3 3 1.000 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.97e-02 3426 3 3 1.000 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.98e-02 3428 3 3 1.000 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.99e-02 3429 3 3 1.000 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.99e-02 3429 3 3 1.000 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.99e-02 3429 3 3 1.000 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 4.99e-02 3430 3 3 1.000 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3431 3 3 1.000 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 516 3 2 0.667 0.004 TF:M07035_1 tf 1 Factor: Beta-catenin; motif: GNNNNCTTTGWTGNY; match class: 1 1 P48147,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 21 3 1 0.333 0.048 HP:0003416 hp 1 Spinal canal stenosis 1 Q13303 259 5.00e-02 828 3 2 0.667 0.002 GO:0098772 MF 1 molecular function regulator 1 Q13303,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 3432 3 3 1.000 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 Q13303,P48147,Q14722 259 5.00e-02 329 3 2 0.667 0.006 MI:hsa-miR-363* mi 1 MI:hsa-miR-363* 1 Q13303,P48147 259 5.00e-02 252 3 2 0.667 0.008 REAC:112316 rea 1 Neuronal System 1 Q13303,Q14722 259 5.00e-02 15 3 1 0.333 0.067 KEGG:04614 keg 1 Renin-angiotensin system 1 P48147 259 5.00e-02 3432 3 3 1.000 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 Q13303,P48147,Q14722 260 7.06e-04 1 2 1 0.500 1.000 GO:0004139 MF 1 deoxyribose-phosphate aldolase activity 1 Q9Y315 260 1.41e-03 2 2 1 0.500 0.500 GO:0046121 BP 1 deoxyribonucleoside catabolic process 1 Q9Y315 260 2.83e-03 4 2 1 0.500 0.250 GO:0019145 MF 1 aminobutyraldehyde dehydrogenase activity 1 Q8IZ83 260 2.83e-03 4 2 1 0.500 0.250 GO:0047105 MF 1 4-trimethylammoniobutyraldehyde dehydrogenase activity 1 Q8IZ83 260 3.53e-03 5 2 1 0.500 0.200 GO:0009120 BP 1 deoxyribonucleoside metabolic process 1 Q9Y315 260 4.24e-03 6 2 1 0.500 0.167 GO:0016832 MF 1 aldehyde-lyase activity 1 Q9Y315 260 1.06e-02 15 2 1 0.500 0.067 GO:0009264 BP 1 deoxyribonucleotide catabolic process 1 Q9Y315 260 1.06e-02 15 2 1 0.500 0.067 GO:0006098 BP 1 pentose-phosphate shunt 1 Q9Y315 260 1.20e-02 17 2 1 0.500 0.059 GO:0004029 MF 1 aldehyde dehydrogenase (NAD) activity 1 Q8IZ83 260 1.20e-02 17 2 1 0.500 0.059 GO:0051156 BP 1 glucose 6-phosphate metabolic process 1 Q9Y315 260 1.41e-02 20 2 1 0.500 0.050 GO:0019682 BP 1 glyceraldehyde-3-phosphate metabolic process 1 Q9Y315 260 1.55e-02 22 2 1 0.500 0.045 GO:0009262 BP 1 deoxyribonucleotide metabolic process 1 Q9Y315 260 1.69e-02 24 2 1 0.500 0.042 GO:0006739 BP 1 NADP metabolic process 1 Q9Y315 260 1.91e-02 27 2 1 0.500 0.037 GO:0009164 BP 1 nucleoside catabolic process 1 Q9Y315 260 2.05e-02 29 2 1 0.500 0.034 GO:0016620 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1 Q8IZ83 260 2.26e-02 32 2 1 0.500 0.031 GO:1901658 BP 1 glycosyl compound catabolic process 1 Q9Y315 260 2.40e-02 34 2 1 0.500 0.029 GO:0016830 MF 1 carbon-carbon lyase activity 1 Q9Y315 260 2.96e-02 42 2 1 0.500 0.024 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Q8IZ83 260 3.10e-02 44 2 1 0.500 0.023 GO:0009166 BP 1 nucleotide catabolic process 1 Q9Y315 260 3.52e-02 50 2 1 0.500 0.020 GO:1901292 BP 1 nucleoside phosphate catabolic process 1 Q9Y315 260 4.51e-02 15 2 1 0.500 0.067 TF:M03965_1 tf 1 Factor: EHF; motif: NACCCGGAAGTA; match class: 1 1 Q8IZ83 260 5.00e-02 651 2 2 1.000 0.003 TF:M03789_0 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 0 1 Q9Y315,Q8IZ83 260 5.00e-02 26 2 1 0.500 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 Q9Y315 260 5.00e-02 71 2 1 0.500 0.014 GO:0006081 BP 1 cellular aldehyde metabolic process 1 Q9Y315 260 5.00e-02 9 2 1 0.500 0.111 REAC:71336 rea 1 Pentose phosphate pathway (hexose monophosphate shunt) 1 Q9Y315 261 2.55e-07 18 5 3 0.600 0.167 REAC:3295583 rea 1 TRP channels 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.08e-06 157 5 4 0.800 0.025 REAC:983712 rea 1 Ion channel transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.82e-06 249 5 4 0.800 0.016 GO:0005216 MF 1 ion channel activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.95e-06 252 5 4 0.800 0.016 GO:0022838 MF 1 substrate-specific channel activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 3.67e-06 266 5 4 0.800 0.015 GO:0015267 MF 1 channel activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 3.67e-06 266 5 4 0.800 0.015 GO:0022803 MF 1 passive transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 3.84e-06 269 5 4 0.800 0.015 GO:0098660 BP 1 inorganic ion transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 5.99e-06 71 5 3 0.600 0.042 GO:0005262 MF 1 calcium channel activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 1.03e-05 85 5 3 0.600 0.035 GO:0015085 MF 1 calcium ion transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.19e-05 416 5 4 0.800 0.010 GO:0034220 BP 1 ion transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.25e-05 110 5 3 0.600 0.027 GO:0072509 MF 1 divalent inorganic cation transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.25e-05 110 5 3 0.600 0.027 GO:0070588 BP 1 calcium ion transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.54e-05 80 5 3 0.600 0.037 REAC:2672351 rea 1 Stimuli-sensing channels 1 Q8TDD5,Q9GZU1,Q8IZK6 261 4.55e-05 500 5 4 0.800 0.008 GO:0015075 MF 1 ion transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 5.70e-05 529 5 4 0.800 0.008 GO:0055085 BP 1 transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 6.00e-05 536 5 4 0.800 0.007 GO:0022891 MF 1 substrate-specific transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 6.55e-05 157 5 3 0.600 0.019 GO:0006816 BP 1 calcium ion transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 8.15e-05 579 5 4 0.800 0.007 GO:0022857 MF 1 transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 9.38e-05 177 5 3 0.600 0.017 GO:0072511 BP 1 divalent inorganic cation transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 9.38e-05 177 5 3 0.600 0.017 GO:0070838 BP 1 divalent metal ion transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 9.87e-05 180 5 3 0.600 0.017 GO:0005261 MF 1 cation channel activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 1.35e-04 658 5 4 0.800 0.006 GO:0022892 MF 1 substrate-specific transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.00e-04 493 5 4 0.800 0.008 REAC:382551 rea 1 Transmembrane transport of small molecules 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.08e-04 733 5 4 0.800 0.005 GO:0006811 BP 1 ion transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.27e-04 750 5 4 0.800 0.005 GO:0005215 MF 1 transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 2.33e-04 240 5 3 0.600 0.013 GO:0098662 BP 1 inorganic cation transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.76e-04 254 5 3 0.600 0.012 GO:0046873 MF 1 metal ion transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.76e-04 254 5 3 0.600 0.012 GO:0098655 BP 1 cation transmembrane transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 4.76e-04 305 5 3 0.600 0.010 GO:0022890 MF 1 inorganic cation transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 6.91e-04 346 5 3 0.600 0.009 GO:0030001 BP 1 metal ion transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 8.03e-04 364 5 3 0.600 0.008 GO:0008324 MF 1 cation transmembrane transporter activity 1 Q8TDD5,Q9GZU1,Q8IZK6 261 1.09e-03 2420 5 5 1.000 0.002 GO:0005886 CC 1 plasma membrane 1 Q8TDD5,Q9GZU1,Q9Y4D2,Q8IZK6,P28472 261 1.21e-03 2469 5 5 1.000 0.002 GO:0071944 CC 1 cell periphery 1 Q8TDD5,Q9GZU1,Q9Y4D2,Q8IZK6,P28472 261 1.41e-03 440 5 3 0.600 0.007 GO:0006812 BP 1 cation transport 1 Q8TDD5,Q9GZU1,Q8IZK6 261 2.34e-03 2 5 1 0.200 0.500 GO:0046340 BP 1 diacylglycerol catabolic process 1 Q9Y4D2 261 5.85e-03 5 5 1 0.200 0.200 GO:0005381 MF 1 iron ion transmembrane transporter activity 1 Q9GZU1 261 5.85e-03 5 5 1 0.200 0.200 GO:0022851 MF 1 GABA-gated chloride ion channel activity 1 P28472 261 5.85e-03 5 5 1 0.200 0.200 GO:0071420 BP 1 cellular response to histamine 1 P28472 261 6.82e-03 5 5 1 0.200 0.200 REAC:426048 rea 1 Arachidonate production from DAG 1 Q9Y4D2 261 7.27e-03 311 5 2 0.400 0.006 MI:hsa-miR-183* mi 1 MI:hsa-miR-183* 1 Q8TDD5,Q8IZK6 261 7.50e-03 196 5 2 0.400 0.010 GO:0043235 CC 1 receptor complex 1 Q9GZU1,P28472 261 8.07e-03 328 5 2 0.400 0.006 MI:hsa-miR-146a* mi 1 MI:hsa-miR-146a* 1 Q8TDD5,Q8IZK6 261 8.18e-03 6 5 1 0.200 0.167 REAC:977441 rea 1 GABA A receptor activation 1 P28472 261 8.19e-03 7 5 1 0.200 0.143 GO:0034776 BP 1 response to histamine 1 P28472 261 9.36e-03 8 5 1 0.200 0.125 GO:0042136 BP 1 neurotransmitter biosynthetic process 1 Q9Y4D2 261 9.36e-03 8 5 1 0.200 0.125 GO:0047372 MF 1 acylglycerol lipase activity 1 Q9Y4D2 261 1.05e-02 9 5 1 0.200 0.111 GO:0099095 MF 1 ligand-gated anion channel activity 1 P28472 261 1.05e-02 9 5 1 0.200 0.111 GO:0046339 BP 1 diacylglycerol metabolic process 1 Q9Y4D2 261 1.17e-02 10 5 1 0.200 0.100 GO:1902711 CC 1 GABA-A receptor complex 1 P28472 261 1.17e-02 10 5 1 0.200 0.100 GO:1902710 CC 1 GABA receptor complex 1 P28472 261 1.17e-02 10 5 1 0.200 0.100 GO:0004890 MF 1 GABA-A receptor activity 1 P28472 261 1.25e-02 1 5 1 0.200 1.000 OMIM:612269 omi 1 EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 5; ECA5 1 P28472 261 1.25e-02 1 5 1 0.200 1.000 OMIM:252650 omi 1 MUCOLIPIDOSIS IV; ML4;;ML IV;;SIALOLIPIDOSIS 1 Q9GZU1 261 1.33e-02 424 5 2 0.400 0.005 MI:mml-miR-000 mi 1 mml miRBase microRNAs 1 Q8TDD5,Q9GZU1 261 1.33e-02 424 5 2 0.400 0.005 MI:mml-miR-189 mi 1 MI:mml-miR-189 1 Q8TDD5,Q9GZU1 261 1.39e-02 434 5 2 0.400 0.005 MI:rno-miR-336 mi 1 MI:rno-miR-336 1 Q9GZU1,Q9Y4D2 261 1.42e-02 439 5 2 0.400 0.005 MI:hsa-miR-363 mi 1 MI:hsa-miR-363 1 Q8TDD5,Q8IZK6 261 1.52e-02 13 5 1 0.200 0.077 GO:0016917 MF 1 GABA receptor activity 1 P28472 261 1.63e-02 12 5 1 0.200 0.083 REAC:975298 rea 1 Ligand-gated ion channel transport 1 P28472 261 1.64e-02 14 5 1 0.200 0.071 GO:0042133 BP 1 neurotransmitter metabolic process 1 Q9Y4D2 261 1.67e-02 2 5 1 0.200 0.500 HP:0007893 hp 1 Progressive retinal degeneration 1 Q9GZU1 261 1.81e-02 499 5 2 0.400 0.004 MI:hsa-miR-20a mi 1 MI:hsa-miR-20a 1 Q8TDD5,Q8IZK6 261 1.91e-02 513 5 2 0.400 0.004 MI:hsa-miR-106b mi 1 MI:hsa-miR-106b 1 Q8TDD5,Q8IZK6 261 1.91e-02 513 5 2 0.400 0.004 MI:hsa-miR-20b mi 1 MI:hsa-miR-20b 1 Q8TDD5,Q8IZK6 261 2.10e-02 539 5 2 0.400 0.004 MI:hsa-let-7g* mi 1 MI:hsa-let-7g* 1 Q8TDD5,Q8IZK6 261 2.22e-02 19 5 1 0.200 0.053 GO:0071242 BP 1 cellular response to ammonium ion 1 P28472 261 2.48e-02 589 5 2 0.400 0.003 MI:mmu-miR-466e-5p mi 1 MI:mmu-miR-466e-5p 1 Q8IZK6,P28472 261 2.57e-02 22 5 1 0.200 0.045 GO:0022824 MF 1 transmitter-gated ion channel activity 1 P28472 261 2.57e-02 22 5 1 0.200 0.045 GO:0022835 MF 1 transmitter-gated channel activity 1 P28472 261 2.57e-02 22 5 1 0.200 0.045 GO:0046461 BP 1 neutral lipid catabolic process 1 Q9Y4D2 261 2.57e-02 22 5 1 0.200 0.045 GO:0046464 BP 1 acylglycerol catabolic process 1 Q9Y4D2 261 2.60e-02 604 5 2 0.400 0.003 MI:mmu-miR-466a-5p mi 1 MI:mmu-miR-466a-5p 1 Q8IZK6,P28472 261 2.68e-02 23 5 1 0.200 0.043 GO:0060359 BP 1 response to ammonium ion 1 P28472 261 2.68e-02 23 5 1 0.200 0.043 GO:0060021 BP 1 palate development 1 P28472 261 2.72e-02 4600 5 5 1.000 0.001 GO:0016020 CC 1 membrane 1 Q8TDD5,Q9GZU1,Q9Y4D2,Q8IZK6,P28472 261 2.92e-02 25 5 1 0.200 0.040 GO:0046915 MF 1 transition metal ion transmembrane transporter activity 1 Q9GZU1 261 3.04e-02 2644 5 4 0.800 0.002 GO:0006810 BP 1 transport 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 3.15e-02 27 5 1 0.200 0.037 GO:1902476 BP 1 chloride transmembrane transport 1 P28472 261 3.25e-02 24 5 1 0.200 0.042 REAC:114508 rea 1 Effects of PIP2 hydrolysis 1 Q9Y4D2 261 3.34e-02 4 5 1 0.200 0.250 HP:0007266 hp 1 Cerebral dysmyelination 1 Q9GZU1 261 3.39e-02 25 5 1 0.200 0.040 REAC:917977 rea 1 Transferrin endocytosis and recycling 1 Q9GZU1 261 3.50e-02 30 5 1 0.200 0.033 GO:0015682 BP 1 ferric iron transport 1 Q9GZU1 261 3.50e-02 30 5 1 0.200 0.033 GO:0033572 BP 1 transferrin transport 1 Q9GZU1 261 3.50e-02 30 5 1 0.200 0.033 GO:0072512 BP 1 trivalent inorganic cation transport 1 Q9GZU1 261 3.50e-02 30 5 1 0.200 0.033 GO:0005230 MF 1 extracellular ligand-gated ion channel activity 1 P28472 261 3.50e-02 30 5 1 0.200 0.033 GO:0019369 BP 1 arachidonic acid metabolic process 1 Q9Y4D2 261 3.50e-02 30 5 1 0.200 0.033 GO:0098661 BP 1 inorganic anion transmembrane transport 1 P28472 261 3.52e-02 2748 5 4 0.800 0.001 GO:0051234 BP 1 establishment of localization 1 Q8TDD5,Q9GZU1,Q8IZK6,P28472 261 3.96e-02 34 5 1 0.200 0.029 GO:0046503 BP 1 glycerolipid catabolic process 1 Q9Y4D2 261 4.17e-02 5 5 1 0.200 0.200 HP:0004345 hp 1 Abnormality of ganglioside metabolism 1 Q9GZU1 261 4.19e-02 36 5 1 0.200 0.028 GO:0006826 BP 1 iron ion transport 1 Q9GZU1 261 5.00e-02 37 5 1 0.200 0.027 REAC:917937 rea 1 Iron uptake and transport 1 Q9GZU1 261 5.00e-02 6 5 1 0.200 0.167 HP:0010849 hp 1 EEG with spike-wave complexes (>3.5 Hz) 1 P28472 261 5.00e-02 6 5 1 0.200 0.167 HP:0007281 hp 1 Developmental stagnation 1 Q9GZU1 261 5.00e-02 80 5 2 0.400 0.025 KEGG:04723 keg 1 Retrograde endocannabinoid signaling 1 Q9Y4D2,P28472 261 5.00e-02 4 5 1 0.200 0.250 OMIM:600131 omi 1 Susceptibility to Childhood Absence Epilepsy 1 P28472 261 5.00e-02 37 5 1 0.200 0.027 REAC:977443 rea 1 GABA receptor activation 1 P28472 261 5.00e-02 2840 5 5 1.000 0.002 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q8TDD5,Q9GZU1,Q9Y4D2,Q8IZK6,P28472 261 5.00e-02 43 5 1 0.200 0.023 GO:0006821 BP 1 chloride transport 1 P28472 262 1.92e-07 2 4 2 0.500 1.000 GO:0004618 MF 1 phosphoglycerate kinase activity 1 P00558,P07205 262 3.22e-07 32 4 3 0.750 0.094 REAC:70263 rea 1 Gluconeogenesis 1 P00558,P13929,P07205 262 3.22e-07 32 4 3 0.750 0.094 REAC:70171 rea 1 Glycolysis 1 P00558,P13929,P07205 262 6.11e-07 49 4 3 0.750 0.061 GO:0006096 BP 1 glycolytic process 1 P00558,P13929,P07205 262 6.50e-07 50 4 3 0.750 0.060 GO:0006757 BP 1 ATP generation from ADP 1 P00558,P13929,P07205 262 7.33e-07 52 4 3 0.750 0.058 GO:0046031 BP 1 ADP metabolic process 1 P00558,P13929,P07205 262 8.23e-07 54 4 3 0.750 0.056 GO:0009135 BP 1 purine nucleoside diphosphate metabolic process 1 P00558,P13929,P07205 262 8.23e-07 54 4 3 0.750 0.056 GO:0009179 BP 1 purine ribonucleoside diphosphate metabolic process 1 P00558,P13929,P07205 262 9.20e-07 56 4 3 0.750 0.054 GO:0006165 BP 1 nucleoside diphosphate phosphorylation 1 P00558,P13929,P07205 262 9.20e-07 56 4 3 0.750 0.054 GO:0009185 BP 1 ribonucleoside diphosphate metabolic process 1 P00558,P13929,P07205 262 9.71e-07 57 4 3 0.750 0.053 GO:0046939 BP 1 nucleotide phosphorylation 1 P00558,P13929,P07205 262 1.15e-06 4 4 2 0.500 0.500 GO:0016774 MF 1 phosphotransferase activity, carboxyl group as acceptor 1 P00558,P07205 262 1.25e-06 62 4 3 0.750 0.048 GO:0009132 BP 1 nucleoside diphosphate metabolic process 1 P00558,P13929,P07205 262 2.33e-06 76 4 3 0.750 0.039 GO:0006090 BP 1 pyruvate metabolic process 1 P00558,P13929,P07205 262 3.39e-06 86 4 3 0.750 0.035 GO:0019362 BP 1 pyridine nucleotide metabolic process 1 P00558,P13929,P07205 262 3.39e-06 86 4 3 0.750 0.035 GO:0046496 BP 1 nicotinamide nucleotide metabolic process 1 P00558,P13929,P07205 262 4.44e-06 94 4 3 0.750 0.032 GO:0006733 BP 1 oxidoreduction coenzyme metabolic process 1 P00558,P13929,P07205 262 4.72e-06 77 4 3 0.750 0.039 REAC:70326 rea 1 Glucose metabolism 1 P00558,P13929,P07205 262 4.88e-06 97 4 3 0.750 0.031 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 P00558,P13929,P07205 262 4.88e-06 97 4 3 0.750 0.031 GO:0072524 BP 1 pyridine-containing compound metabolic process 1 P00558,P13929,P07205 262 5.68e-06 102 4 3 0.750 0.029 GO:0016052 BP 1 carbohydrate catabolic process 1 P00558,P13929,P07205 262 1.16e-05 62 4 3 0.750 0.048 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P00558,P13929,P07205 262 1.60e-05 69 4 3 0.750 0.043 KEGG:01230 keg 1 Biosynthesis of amino acids 1 P00558,P13929,P07205 262 3.04e-05 178 4 3 0.750 0.017 GO:0046034 BP 1 ATP metabolic process 1 P00558,P13929,P07205 262 3.64e-05 189 4 3 0.750 0.016 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P00558,P13929,P07205 262 3.70e-05 190 4 3 0.750 0.016 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P00558,P13929,P07205 262 3.88e-05 193 4 3 0.750 0.016 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P00558,P13929,P07205 262 4.38e-05 201 4 3 0.750 0.015 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P00558,P13929,P07205 262 4.38e-05 201 4 3 0.750 0.015 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P00558,P13929,P07205 262 4.51e-05 203 4 3 0.750 0.015 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P00558,P13929,P07205 262 4.72e-05 206 4 3 0.750 0.015 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P00558,P13929,P07205 262 5.00e-05 210 4 3 0.750 0.014 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P00558,P13929,P07205 262 5.29e-05 214 4 3 0.750 0.014 GO:0006732 BP 1 coenzyme metabolic process 1 P00558,P13929,P07205 262 6.04e-05 107 4 3 0.750 0.028 KEGG:01200 keg 1 Carbon metabolism 1 P00558,P13929,P07205 262 6.22e-05 26 4 2 0.500 0.077 GO:0061620 BP 1 glycolytic process through glucose-6-phosphate 1 P00558,P13929 262 6.22e-05 26 4 2 0.500 0.077 GO:0061718 BP 1 glucose catabolic process to pyruvate 1 P00558,P13929 262 6.22e-05 26 4 2 0.500 0.077 GO:0061615 BP 1 glycolytic process through fructose-6-phosphate 1 P00558,P13929 262 6.22e-05 26 4 2 0.500 0.077 GO:0061621 BP 1 canonical glycolysis 1 P00558,P13929 262 6.22e-05 26 4 2 0.500 0.077 GO:0006735 BP 1 NADH regeneration 1 P00558,P13929 262 7.23e-05 28 4 2 0.500 0.071 GO:0006007 BP 1 glucose catabolic process 1 P00558,P13929 262 7.46e-05 240 4 3 0.750 0.013 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P00558,P13929,P07205 262 7.74e-05 243 4 3 0.750 0.012 GO:0042278 BP 1 purine nucleoside metabolic process 1 P00558,P13929,P07205 262 8.32e-05 30 4 2 0.500 0.067 GO:0006734 BP 1 NADH metabolic process 1 P00558,P13929 262 8.53e-05 251 4 3 0.750 0.012 GO:0009119 BP 1 ribonucleoside metabolic process 1 P00558,P13929,P07205 262 9.15e-05 257 4 3 0.750 0.012 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P00558,P13929,P07205 262 1.03e-04 267 4 3 0.750 0.011 GO:0051186 BP 1 cofactor metabolic process 1 P00558,P13929,P07205 262 1.15e-04 277 4 3 0.750 0.011 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 P00558,P13929,P07205 262 1.20e-04 281 4 3 0.750 0.011 GO:0009116 BP 1 nucleoside metabolic process 1 P00558,P13929,P07205 262 1.44e-04 299 4 3 0.750 0.010 GO:1901657 BP 1 glycosyl compound metabolic process 1 P00558,P13929,P07205 262 1.50e-04 303 4 3 0.750 0.010 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P00558,P13929,P07205 262 1.55e-04 246 4 3 0.750 0.012 REAC:71387 rea 1 Metabolism of carbohydrates 1 P00558,P13929,P07205 262 1.56e-04 307 4 3 0.750 0.010 GO:0009259 BP 1 ribonucleotide metabolic process 1 P00558,P13929,P07205 262 1.65e-04 42 4 2 0.500 0.048 GO:0019674 BP 1 NAD metabolic process 1 P00558,P13929 262 1.75e-04 319 4 3 0.750 0.009 GO:0019693 BP 1 ribose phosphate metabolic process 1 P00558,P13929,P07205 262 1.81e-04 44 4 2 0.500 0.045 GO:0019320 BP 1 hexose catabolic process 1 P00558,P13929 262 1.83e-04 324 4 3 0.750 0.009 GO:0005975 BP 1 carbohydrate metabolic process 1 P00558,P13929,P07205 262 1.83e-04 324 4 3 0.750 0.009 GO:0006163 BP 1 purine nucleotide metabolic process 1 P00558,P13929,P07205 262 2.31e-04 350 4 3 0.750 0.009 GO:0072521 BP 1 purine-containing compound metabolic process 1 P00558,P13929,P07205 262 2.36e-04 353 4 3 0.750 0.008 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P00558,P13929,P07205 262 2.43e-04 51 4 2 0.500 0.039 GO:0006094 BP 1 gluconeogenesis 1 P00558,P13929 262 2.53e-04 52 4 2 0.500 0.038 GO:0046365 BP 1 monosaccharide catabolic process 1 P00558,P13929 262 2.73e-04 54 4 2 0.500 0.037 GO:0019319 BP 1 hexose biosynthetic process 1 P00558,P13929 262 3.14e-04 388 4 3 0.750 0.008 GO:0009117 BP 1 nucleotide metabolic process 1 P00558,P13929,P07205 262 3.15e-04 58 4 2 0.500 0.034 GO:0046364 BP 1 monosaccharide biosynthetic process 1 P00558,P13929 262 3.38e-04 398 4 3 0.750 0.008 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P00558,P13929,P07205 262 4.88e-04 450 4 3 0.750 0.007 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P00558,P13929,P07205 262 7.19e-04 1565 4 4 1.000 0.003 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P00558,P13929,P43897,P07205 262 9.95e-04 572 4 3 0.750 0.005 GO:0044712 BP 1 single-organism catabolic process 1 P00558,P13929,P07205 262 1.14e-03 110 4 2 0.500 0.018 GO:0006006 BP 1 glucose metabolic process 1 P00558,P13929 262 1.24e-03 115 4 2 0.500 0.017 GO:0016051 BP 1 carbohydrate biosynthetic process 1 P00558,P13929 262 1.45e-03 650 4 3 0.750 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 P00558,P13929,P07205 262 1.62e-03 674 4 3 0.750 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 P00558,P13929,P07205 262 1.76e-03 137 4 2 0.500 0.015 GO:0019318 BP 1 hexose metabolic process 1 P00558,P13929 262 1.88e-03 1 4 1 0.250 1.000 OMIM:610505 omi 1 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 3; COXPD3;;ENCEPHALOMYOPATHY, RESPIRATORY FAILURE, AND LACTIC ACIDOSIS;;CONCENTRIC CARDIOMYOPATHY, HYPOTONIA, AND LACTIC ACIDOSIS 1 P43897 262 1.88e-03 1 4 1 0.250 1.000 OMIM:300653 omi 1 PHOSPHOGLYCERATE KINASE 1 DEFICIENCY;;PGK1 DEFICIENCY 1 P00558 262 1.88e-03 1 4 1 0.250 1.000 OMIM:612932 omi 1 GLYCOGEN STORAGE DISEASE XIII; GSD13;;GSD XIII;;ENOLASE 3 DEFICIENCY;;ENOLASE-BETA DEFICIENCY 1 P13929 262 1.90e-03 1015 4 3 0.750 0.003 TF:M00339_1 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 1 P00558,P13929,P43897 262 2.04e-03 729 4 3 0.750 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 P00558,P13929,P07205 262 2.12e-03 739 4 3 0.750 0.004 GO:0006082 BP 1 organic acid metabolic process 1 P00558,P13929,P07205 262 2.21e-03 3 4 1 0.250 0.333 GO:0004634 MF 1 phosphopyruvate hydratase activity 1 P13929 262 2.66e-03 798 4 3 0.750 0.004 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P00558,P13929,P07205 262 2.70e-03 170 4 2 0.500 0.012 GO:0005996 BP 1 monosaccharide metabolic process 1 P00558,P13929 262 2.80e-03 86 4 2 0.500 0.023 KEGG:04066 keg 1 HIF-1 signaling pathway 1 P00558,P13929 262 3.77e-03 12 4 1 0.250 0.083 TF:M03865_1 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 1 1 P43897 262 4.08e-03 13 4 1 0.250 0.077 TF:M06865_1 tf 1 Factor: PLAG1; motif: NTGGGGTGGGGG; match class: 1 1 P13929 262 4.39e-03 14 4 1 0.250 0.071 TF:M00956_1 tf 1 Factor: AR; motif: NNNNNNRGNACRNNGTGTTCTNNNNNN; match class: 1 1 P43897 262 4.97e-03 231 4 2 0.500 0.009 GO:0005524 MF 1 ATP binding 1 P00558,P07205 262 5.62e-03 246 4 2 0.500 0.008 GO:0044282 BP 1 small molecule catabolic process 1 P00558,P13929 262 5.96e-03 19 4 1 0.250 0.053 TF:M05624_0 tf 1 Factor: PRD51; motif: TGGGGCTGAATC; match class: 0 1 P13929 262 6.04e-03 255 4 2 0.500 0.008 GO:0032559 MF 1 adenyl ribonucleotide binding 1 P00558,P07205 262 6.51e-03 265 4 2 0.500 0.008 GO:0030554 MF 1 adenyl nucleotide binding 1 P00558,P07205 262 7.83e-03 25 4 1 0.250 0.040 TF:M06240_0 tf 1 Factor: ZNF616; motif: NGGGTGGAACGM; match class: 0 1 P13929 262 8.04e-03 421 4 2 0.500 0.005 MI:hsa-miR-607 mi 1 MI:hsa-miR-607 1 P43897,P07205 262 8.54e-03 304 4 2 0.500 0.007 GO:0044283 BP 1 small molecule biosynthetic process 1 P00558,P13929 262 8.84e-03 12 4 1 0.250 0.083 GO:0003746 MF 1 translation elongation factor activity 1 P43897 262 9.85e-03 327 4 2 0.500 0.006 GO:0035639 MF 1 purine ribonucleoside triphosphate binding 1 P00558,P07205 262 1.03e-02 1266 4 3 0.750 0.002 GO:0016310 BP 1 phosphorylation 1 P00558,P13929,P07205 262 1.06e-02 551 4 2 0.500 0.004 TF:M00223_0 tf 1 Factor: STAT; motif: TTCCCGKAA; match class: 0 1 P00558,P13929 262 1.09e-02 1290 4 3 0.750 0.002 GO:1901575 BP 1 organic substance catabolic process 1 P00558,P13929,P07205 262 1.12e-02 349 4 2 0.500 0.006 GO:0032549 MF 1 ribonucleoside binding 1 P00558,P07205 262 1.12e-02 349 4 2 0.500 0.006 GO:0032550 MF 1 purine ribonucleoside binding 1 P00558,P07205 262 1.13e-02 350 4 2 0.500 0.006 GO:0001883 MF 1 purine nucleoside binding 1 P00558,P07205 262 1.14e-02 353 4 2 0.500 0.006 GO:0001882 MF 1 nucleoside binding 1 P00558,P07205 262 1.20e-02 1333 4 3 0.750 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P00558,P13929,P07205 262 1.23e-02 366 4 2 0.500 0.005 GO:0032555 MF 1 purine ribonucleotide binding 1 P00558,P07205 262 1.27e-02 372 4 2 0.500 0.005 GO:0032553 MF 1 ribonucleotide binding 1 P00558,P07205 262 1.28e-02 1362 4 3 0.750 0.002 GO:0009056 BP 1 catabolic process 1 P00558,P13929,P07205 262 1.29e-02 375 4 2 0.500 0.005 GO:0055114 BP 1 oxidation-reduction process 1 P00558,P13929 262 1.31e-02 378 4 2 0.500 0.005 GO:0017076 MF 1 purine nucleotide binding 1 P00558,P07205 262 1.38e-02 44 4 1 0.250 0.023 TF:M06021_0 tf 1 Factor: ZNF98; motif: NTGGAWAGAAGA; match class: 0 1 P07205 262 1.47e-02 2049 4 3 0.750 0.001 TF:M01876_0 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 0 1 P00558,P13929,P43897 262 1.49e-02 4447 4 4 1.000 0.001 TF:M03998_0 tf 1 Factor: GATA4; motif: WGATAANN; match class: 0 1 P00558,P13929,P43897,P07205 262 1.49e-02 2061 4 3 0.750 0.001 TF:M00777_0 tf 1 Factor: STAT; motif: NNNNNTTCTKGGA; match class: 0 1 P00558,P43897,P07205 262 1.69e-02 3443 4 4 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P00558,P13929,P43897,P07205 262 1.83e-02 731 4 2 0.500 0.003 TF:M07353_1 tf 1 Factor: E2A; motif: CAGNTGNN; match class: 1 1 P13929,P43897 262 1.84e-02 59 4 1 0.250 0.017 TF:M04046_0 tf 1 Factor: MYBL2; motif: AACSGTTAACSGNY; match class: 0 1 P07205 262 1.90e-02 61 4 1 0.250 0.016 TF:M01239_1 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 1 1 P13929 262 1.92e-02 3554 4 4 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 P00558,P13929,P43897,P07205 262 1.93e-02 3561 4 4 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P00558,P13929,P43897,P07205 262 2.06e-02 66 4 1 0.250 0.015 TF:M00209_1 tf 1 Factor: NF-Y; motif: NCTGATTGGYTASY; match class: 1 1 P00558 262 2.08e-02 479 4 2 0.500 0.004 GO:0000166 MF 1 nucleotide binding 1 P00558,P07205 262 2.09e-02 480 4 2 0.500 0.004 GO:1901265 MF 1 nucleoside phosphate binding 1 P00558,P07205 262 2.09e-02 67 4 1 0.250 0.015 TF:M00287_1 tf 1 Factor: NF-Y; motif: NNNRRCCAATSRGNNN; match class: 1 1 P00558 262 2.09e-02 67 4 1 0.250 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 P43897 262 2.18e-02 70 4 1 0.250 0.014 TF:M06184_0 tf 1 Factor: ZNF85; motif: NGGGATGGAAGM; match class: 0 1 P07205 262 2.20e-02 3681 4 4 1.000 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P00558,P13929,P43897,P07205 262 2.27e-02 4943 4 4 1.000 0.001 TF:M00762_0 tf 1 Factor: PPAR,; motif: RGGNCAAAGGTCA; match class: 0 1 P00558,P13929,P43897,P07205 262 2.37e-02 76 4 1 0.250 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 P43897 262 2.50e-02 34 4 1 0.250 0.029 GO:0021762 BP 1 substantia nigra development 1 P13929 262 2.58e-02 2498 4 3 0.750 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 P00558,P13929,P43897 262 2.58e-02 2498 4 3 0.750 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 P00558,P13929,P43897 262 2.62e-02 540 4 2 0.500 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 P00558,P07205 262 2.64e-02 36 4 1 0.250 0.028 GO:0032784 BP 1 regulation of DNA-templated transcription, elongation 1 P43897 262 2.64e-02 36 4 1 0.250 0.028 GO:0048857 BP 1 neural nucleus development 1 P13929 262 2.67e-02 2528 4 3 0.750 0.001 TF:M02117_0 tf 1 Factor: STAT4; motif: TTMNNRGAAA; match class: 0 1 P00558,P13929,P43897 262 2.67e-02 891 4 2 0.500 0.002 TF:M00210_0 tf 1 Factor: OCT-x; motif: CTNATTTGCATAY; match class: 0 1 P00558,P07205 262 2.68e-02 86 4 1 0.250 0.012 TF:M07434_1 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 1 1 P00558 262 2.74e-02 88 4 1 0.250 0.011 TF:M05988_0 tf 1 Factor: ZNF860; motif: NTGGGAAAWGSM; match class: 0 1 P00558 262 2.74e-02 88 4 1 0.250 0.011 TF:M01116_1 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 1 1 P00558 262 2.74e-02 903 4 2 0.500 0.002 TF:M04415_1 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 1 1 P00558,P07205 262 2.86e-02 5233 4 4 1.000 0.001 TF:M07379_0 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 0 1 P00558,P13929,P43897,P07205 262 2.86e-02 39 4 1 0.250 0.026 GO:0016836 MF 1 hydro-lyase activity 1 P13929 262 2.92e-02 933 4 2 0.500 0.002 TF:M00095_0 tf 1 Factor: CDP; motif: CCAATAATCGAT; match class: 0 1 P00558,P07205 262 2.92e-02 3948 4 4 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P00558,P13929,P43897,P07205 262 3.09e-02 1851 4 3 0.750 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P00558,P13929,P07205 262 3.11e-02 100 4 1 0.250 0.010 TF:M06541_0 tf 1 Factor: ZNF502; motif: NGKTAGGRAATC; match class: 0 1 P07205 262 3.14e-02 101 4 1 0.250 0.010 TF:M05459_0 tf 1 Factor: SCRT2; motif: GTCAAMCGA; match class: 0 1 P43897 262 3.20e-02 103 4 1 0.250 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 P00558 262 3.20e-02 103 4 1 0.250 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 P13929 262 3.26e-02 105 4 1 0.250 0.010 TF:M06407_0 tf 1 Factor: ZNF677; motif: NKTTAAAAAACA; match class: 0 1 P07205 262 3.26e-02 105 4 1 0.250 0.010 TF:M07415_0 tf 1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 0 1 P13929 262 3.34e-02 612 4 2 0.500 0.003 GO:0036094 MF 1 small molecule binding 1 P00558,P07205 262 3.39e-02 1010 4 2 0.500 0.002 TF:M03832_0 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 0 1 P13929,P43897 262 3.45e-02 1923 4 3 0.750 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 P00558,P13929,P07205 262 3.47e-02 112 4 1 0.250 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 P00558 262 3.53e-02 630 4 2 0.500 0.003 GO:0016301 MF 1 kinase activity 1 P00558,P07205 262 3.54e-02 114 4 1 0.250 0.009 TF:M07314_1 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 1 1 P43897 262 3.57e-02 115 4 1 0.250 0.009 TF:M07103_0 tf 1 Factor: JunB; motif: NRRTGASTCAK; match class: 0 1 P07205 262 3.69e-02 119 4 1 0.250 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 P13929 262 3.69e-02 119 4 1 0.250 0.008 TF:M00693_1 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 1 1 P13929 262 3.74e-02 51 4 1 0.250 0.020 GO:0030901 BP 1 midbrain development 1 P13929 262 3.76e-02 1067 4 2 0.500 0.002 TF:M01303_0 tf 1 Factor: SP1; motif: GGGGYGGGGNS; match class: 0 1 P00558,P13929 262 3.78e-02 1070 4 2 0.500 0.002 TF:M07058_1 tf 1 Factor: POU2F1; motif: ATTTGCATN; match class: 1 1 P00558,P07205 262 3.81e-02 123 4 1 0.250 0.008 TF:M05680_0 tf 1 Factor: ZNF80; motif: NTGGGCTGGGGW; match class: 0 1 P00558 262 3.84e-02 124 4 1 0.250 0.008 TF:M05358_0 tf 1 Factor: RLF; motif: GCATCRWCATT; match class: 0 1 P43897 262 3.97e-02 4264 4 4 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P00558,P13929,P43897,P07205 262 4.02e-02 130 4 1 0.250 0.008 TF:M07328_0 tf 1 Factor: NF-AT5; motif: KGKRWTTTTCCAN; match class: 0 1 P13929 262 4.04e-02 1109 4 2 0.500 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 P43897,P07205 262 4.10e-02 56 4 1 0.250 0.018 GO:0016835 MF 1 carbon-oxygen lyase activity 1 P13929 262 4.15e-02 134 4 1 0.250 0.007 TF:M00186_0 tf 1 Factor: SRF; motif: GNCCAWATAWGGMN; match class: 0 1 P13929 262 4.15e-02 134 4 1 0.250 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 P13929 262 4.15e-02 1125 4 2 0.500 0.002 TF:M07385_0 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 0 1 P00558,P07205 262 4.31e-02 3000 4 3 0.750 0.001 TF:M04238_0 tf 1 Factor: FOXD2; motif: NRNWAATATTTAYN; match class: 0 1 P00558,P43897,P07205 262 4.33e-02 140 4 1 0.250 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 P13929 262 4.34e-02 3008 4 3 0.750 0.001 TF:M00232_0 tf 1 Factor: MEF-2A; motif: NNNNNWKCTAWAAATAGMNNNN; match class: 0 1 P13929,P43897,P07205 262 4.49e-02 3045 4 3 0.750 0.001 TF:M07321_0 tf 1 Factor: HNF-4A; motif: NGNNCAAAGKYCAN; match class: 0 1 P13929,P43897,P07205 262 4.51e-02 1718 4 3 0.750 0.002 REAC:1430728 rea 1 Metabolism 1 P00558,P13929,P07205 262 4.57e-02 148 4 1 0.250 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 P00558 262 4.63e-02 150 4 1 0.250 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 P13929 262 4.63e-02 150 4 1 0.250 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 P00558 262 4.72e-02 3100 4 3 0.750 0.001 TF:M00377_1 tf 1 Factor: Pax-4; motif: NAAWAATTANS; match class: 1 1 P00558,P13929,P07205 262 4.73e-02 85 4 1 0.250 0.012 REAC:5389840 rea 1 Mitochondrial translation elongation 1 P43897 262 4.78e-02 155 4 1 0.250 0.006 TF:M06428_0 tf 1 Factor: ZNF227; motif: NKGTAAAAAASM; match class: 0 1 P00558 262 4.81e-02 1217 4 2 0.500 0.002 TF:M07261_1 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 1 P13929,P07205 262 4.88e-02 1227 4 2 0.500 0.002 TF:M07314_0 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 0 1 P00558,P43897 262 5.00e-02 1048 4 3 0.750 0.003 KEGG:01100 keg 1 Metabolic pathways 1 P00558,P13929,P07205 262 5.00e-02 90 4 1 0.250 0.011 REAC:5368287 rea 1 Mitochondrial translation 1 P43897 263 1.10e-03 1 4 1 0.250 1.000 GO:0004655 MF 1 porphobilinogen synthase activity 1 P13716 263 1.10e-03 1 4 1 0.250 1.000 GO:0015198 MF 1 oligopeptide transporter activity 1 Q9NP78 263 1.10e-03 1 4 1 0.250 1.000 GO:0035673 MF 1 oligopeptide transmembrane transporter activity 1 Q9NP78 263 1.10e-03 1 4 1 0.250 1.000 GO:0006214 BP 1 thymidine catabolic process 1 Q12882 263 1.10e-03 1 4 1 0.250 1.000 GO:0015421 MF 1 oligopeptide-transporting ATPase activity 1 Q9NP78 263 1.10e-03 1 4 1 0.250 1.000 GO:0046127 BP 1 pyrimidine deoxyribonucleoside catabolic process 1 Q12882 263 1.10e-03 1 4 1 0.250 1.000 GO:0017113 MF 1 dihydropyrimidine dehydrogenase (NADP+) activity 1 Q12882 263 1.10e-03 1 4 1 0.250 1.000 GO:0032791 MF 1 lead ion binding 1 P13716 263 2.14e-03 647 4 3 0.750 0.005 GO:0042802 MF 1 identical protein binding 1 P13716,Q9NP78,Q12882 263 2.21e-03 2 4 1 0.250 0.500 GO:0006212 BP 1 uracil catabolic process 1 Q12882 263 2.21e-03 2 4 1 0.250 0.500 GO:0019860 BP 1 uracil metabolic process 1 Q12882 263 2.21e-03 2 4 1 0.250 0.500 GO:0046121 BP 1 deoxyribonucleoside catabolic process 1 Q12882 263 2.21e-03 2 4 1 0.250 0.500 GO:0015440 MF 1 peptide-transporting ATPase activity 1 Q9NP78 263 3.31e-03 3 4 1 0.250 0.333 GO:0006208 BP 1 pyrimidine nucleobase catabolic process 1 Q12882 263 3.31e-03 3 4 1 0.250 0.333 GO:0019859 BP 1 thymine metabolic process 1 Q12882 263 3.31e-03 3 4 1 0.250 0.333 GO:0046104 BP 1 thymidine metabolic process 1 Q12882 263 3.31e-03 3 4 1 0.250 0.333 GO:0046125 BP 1 pyrimidine deoxyribonucleoside metabolic process 1 Q12882 263 3.31e-03 3 4 1 0.250 0.333 GO:0006210 BP 1 thymine catabolic process 1 Q12882 263 3.31e-03 3 4 1 0.250 0.333 GO:0006145 BP 1 purine nucleobase catabolic process 1 Q12882 263 4.42e-03 4 4 1 0.250 0.250 GO:1904680 MF 1 peptide transmembrane transporter activity 1 Q9NP78 263 4.50e-03 313 4 2 0.500 0.006 MI:hsa-miR-26a-2* mi 1 MI:hsa-miR-26a-2* 1 Q9NP78,Q12882 263 5.52e-03 5 4 1 0.250 0.200 GO:0009120 BP 1 deoxyribonucleoside metabolic process 1 Q12882 263 5.52e-03 5 4 1 0.250 0.200 GO:0046113 BP 1 nucleobase catabolic process 1 Q12882 263 6.38e-03 374 4 2 0.500 0.005 MI:hsa-miR-21* mi 1 MI:hsa-miR-21* 1 Q9NP78,Q12882 263 6.62e-03 6 4 1 0.250 0.167 GO:0002484 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002485 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002477 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class Ib 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002488 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002489 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002481 BP 1 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002589 BP 1 regulation of antigen processing and presentation of peptide antigen via MHC class I 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002428 BP 1 antigen processing and presentation of peptide antigen via MHC class Ib 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002476 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class Ib 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0002591 BP 1 positive regulation of antigen processing and presentation of peptide antigen via MHC class I 1 Q9NP78 263 6.62e-03 6 4 1 0.250 0.167 GO:0042887 MF 1 amide transmembrane transporter activity 1 Q9NP78 263 7.73e-03 7 4 1 0.250 0.143 GO:0002585 BP 1 positive regulation of antigen processing and presentation of peptide antigen 1 Q9NP78 263 7.73e-03 7 4 1 0.250 0.143 GO:0015197 MF 1 peptide transporter activity 1 Q9NP78 263 7.73e-03 7 4 1 0.250 0.143 GO:0002583 BP 1 regulation of antigen processing and presentation of peptide antigen 1 Q9NP78 263 7.73e-03 7 4 1 0.250 0.143 GO:0002475 BP 1 antigen processing and presentation via MHC class Ib 1 Q9NP78 263 8.34e-03 429 4 2 0.500 0.005 MI:hsa-miR-542-5p mi 1 MI:hsa-miR-542-5p 1 Q9NP78,Q12882 263 8.83e-03 8 4 1 0.250 0.125 GO:0019885 BP 1 antigen processing and presentation of endogenous peptide antigen via MHC class I 1 Q9NP78 263 8.83e-03 8 4 1 0.250 0.125 GO:0002483 BP 1 antigen processing and presentation of endogenous peptide antigen 1 Q9NP78 263 9.93e-03 9 4 1 0.250 0.111 GO:0008239 MF 1 dipeptidyl-peptidase activity 1 Q9NQE7 263 9.93e-03 9 4 1 0.250 0.111 GO:0002579 BP 1 positive regulation of antigen processing and presentation 1 Q9NP78 263 9.93e-03 9 4 1 0.250 0.111 GO:0019883 BP 1 antigen processing and presentation of endogenous antigen 1 Q9NP78 263 1.16e-02 508 4 2 0.500 0.004 MI:mmu-miR-669b mi 1 MI:mmu-miR-669b 1 Q9NP78,Q12882 263 1.21e-02 11 4 1 0.250 0.091 GO:0006206 BP 1 pyrimidine nucleobase metabolic process 1 Q12882 263 1.21e-02 11 4 1 0.250 0.091 GO:0002577 BP 1 regulation of antigen processing and presentation 1 Q9NP78 263 1.32e-02 12 4 1 0.250 0.083 GO:0070008 MF 1 serine-type exopeptidase activity 1 Q9NQE7 263 1.32e-02 12 4 1 0.250 0.083 GO:0004185 MF 1 serine-type carboxypeptidase activity 1 Q9NQE7 263 1.43e-02 13 4 1 0.250 0.077 GO:0046135 BP 1 pyrimidine nucleoside catabolic process 1 Q12882 263 1.54e-02 14 4 1 0.250 0.071 GO:0006783 BP 1 heme biosynthetic process 1 P13716 263 1.54e-02 14 4 1 0.250 0.071 GO:0006144 BP 1 purine nucleobase metabolic process 1 Q12882 263 1.61e-02 342 4 2 0.500 0.006 GO:0005764 CC 1 lysosome 1 Q9NQE7,Q9NP78 263 1.61e-02 342 4 2 0.500 0.006 GO:0000323 CC 1 lytic vacuole 1 Q9NQE7,Q9NP78 263 1.63e-02 1291 4 3 0.750 0.002 GO:0043167 MF 1 ion binding 1 P13716,Q9NP78,Q12882 263 1.76e-02 16 4 1 0.250 0.062 GO:0006779 BP 1 porphyrin-containing compound biosynthetic process 1 P13716 263 1.87e-02 17 4 1 0.250 0.059 GO:0033014 BP 1 tetrapyrrole biosynthetic process 1 P13716 263 1.87e-02 17 4 1 0.250 0.059 GO:0016628 MF 1 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1 Q12882 263 2.09e-02 10 4 1 0.250 0.100 REAC:189451 rea 1 Heme biosynthesis 1 P13716 263 2.12e-02 394 4 2 0.500 0.005 GO:0005773 CC 1 vacuole 1 Q9NQE7,Q9NP78 263 2.20e-02 20 4 1 0.250 0.050 GO:0042168 BP 1 heme metabolic process 1 P13716 263 2.30e-02 11 4 1 0.250 0.091 REAC:73621 rea 1 Pyrimidine catabolism 1 Q12882 263 2.42e-02 22 4 1 0.250 0.045 GO:0006778 BP 1 porphyrin-containing compound metabolic process 1 P13716 263 2.64e-02 24 4 1 0.250 0.042 GO:0072529 BP 1 pyrimidine-containing compound catabolic process 1 Q12882 263 2.64e-02 24 4 1 0.250 0.042 GO:0009112 BP 1 nucleobase metabolic process 1 Q12882 263 2.69e-02 445 4 2 0.500 0.004 GO:0042803 MF 1 protein homodimerization activity 1 Q9NP78,Q12882 263 2.75e-02 25 4 1 0.250 0.040 GO:0050661 MF 1 NADP binding 1 Q12882 263 2.95e-02 466 4 2 0.500 0.004 GO:0005768 CC 1 endosome 1 Q9NQE7,Q9NP78 263 2.97e-02 27 4 1 0.250 0.037 GO:0009164 BP 1 nucleoside catabolic process 1 Q12882 263 3.11e-02 479 4 2 0.500 0.004 GO:0000166 MF 1 nucleotide binding 1 Q9NP78,Q12882 263 3.12e-02 480 4 2 0.500 0.004 GO:1901265 MF 1 nucleoside phosphate binding 1 Q9NP78,Q12882 263 3.19e-02 29 4 1 0.250 0.034 GO:0046148 BP 1 pigment biosynthetic process 1 P13716 263 3.34e-02 16 4 1 0.250 0.062 REAC:189445 rea 1 Metabolism of porphyrins 1 P13716 263 3.41e-02 31 4 1 0.250 0.032 GO:0006213 BP 1 pyrimidine nucleoside metabolic process 1 Q12882 263 3.41e-02 31 4 1 0.250 0.032 GO:0004177 MF 1 aminopeptidase activity 1 Q9NQE7 263 3.47e-02 18 4 1 0.250 0.056 KEGG:00770 keg 1 Pantothenate and CoA biosynthesis 1 Q12882 263 3.52e-02 32 4 1 0.250 0.031 GO:1901658 BP 1 glycosyl compound catabolic process 1 Q12882 263 3.85e-02 35 4 1 0.250 0.029 GO:0004180 MF 1 carboxypeptidase activity 1 Q9NQE7 263 3.96e-02 36 4 1 0.250 0.028 GO:0033013 BP 1 tetrapyrrole metabolic process 1 P13716 263 4.18e-02 38 4 1 0.250 0.026 GO:0072523 BP 1 purine-containing compound catabolic process 1 Q12882 263 4.21e-02 560 4 2 0.500 0.004 GO:0046983 MF 1 protein dimerization activity 1 Q9NP78,Q12882 263 4.29e-02 39 4 1 0.250 0.026 GO:0016836 MF 1 hydro-lyase activity 1 P13716 263 4.29e-02 39 4 1 0.250 0.026 GO:0042440 BP 1 pigment metabolic process 1 P13716 263 4.40e-02 40 4 1 0.250 0.025 GO:0050660 MF 1 flavin adenine dinucleotide binding 1 Q12882 263 4.69e-02 4019 4 4 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 Q9NQE7,P13716,Q9NP78,Q12882 263 4.94e-02 45 4 1 0.250 0.022 GO:0016627 MF 1 oxidoreductase activity, acting on the CH-CH group of donors 1 Q12882 263 5.00e-02 24 4 1 0.250 0.042 REAC:73848 rea 1 Pyrimidine metabolism 1 Q12882 263 5.00e-02 1 4 1 0.250 1.000 OMIM:274270 omi 1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY;;DPD DEFICIENCY;;DPYD DEFICIENCY;;THYMINE-URACILURIA, HEREDITARY;;PYRIMIDINEMIA, FAMILIAL5-@FLUOROURACIL TOXICITY, INCLUDED 1 Q12882 263 5.00e-02 1 4 1 0.250 1.000 OMIM:612740 omi 1 PORPHYRIA, ACUTE HEPATIC;;DELTA-AMINOLEVULINATE DEHYDRATASE DEFICIENCY;;ALAD DEFICIENCY;;PORPHYRIA, ALAD;;PORPHOBILINOGEN SYNTHASE DEFICIENCY;;DOSS PORPHYRIALEAD POISONING, SUSCEPTIBILITY TO, INCLUDED 1 P13716 263 5.00e-02 114 4 2 0.500 0.018 TF:M04218_1 tf 1 Factor: MAFK; motif: NTGCTGANTCAGCRN; match class: 1 1 Q9NQE7,Q9NP78 263 5.00e-02 1 4 1 0.250 1.000 HP:0011848 hp 1 Abdominal colic 1 P13716 263 5.00e-02 26 4 1 0.250 0.038 KEGG:00410 keg 1 beta-Alanine metabolism 1 Q12882 263 5.00e-02 612 4 2 0.500 0.003 GO:0036094 MF 1 small molecule binding 1 Q9NP78,Q12882 264 2.93e-06 60 4 3 0.750 0.050 GO:0042058 BP 1 regulation of epidermal growth factor receptor signaling pathway 1 O43639,Q13191,Q99704 264 3.24e-06 62 4 3 0.750 0.048 GO:1901184 BP 1 regulation of ERBB signaling pathway 1 O43639,Q13191,Q99704 264 1.26e-05 97 4 3 0.750 0.031 GO:0007173 BP 1 epidermal growth factor receptor signaling pathway 1 O43639,Q13191,Q99704 264 2.05e-05 114 4 3 0.750 0.026 GO:0038127 BP 1 ERBB signaling pathway 1 O43639,Q13191,Q99704 264 4.51e-05 14 4 2 0.500 0.143 GO:0007176 BP 1 regulation of epidermal growth factor-activated receptor activity 1 O43639,Q13191 264 2.30e-04 31 4 2 0.500 0.065 GO:0061097 BP 1 regulation of protein tyrosine kinase activity 1 O43639,Q13191 264 7.05e-04 54 4 2 0.500 0.037 GO:0030838 BP 1 positive regulation of actin filament polymerization 1 O43639,A6NGB9 264 1.06e-03 66 4 2 0.500 0.030 GO:0010469 BP 1 regulation of receptor activity 1 O43639,Q13191 264 1.06e-03 66 4 2 0.500 0.030 GO:0032273 BP 1 positive regulation of protein polymerization 1 O43639,A6NGB9 264 1.12e-03 432 4 3 0.750 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 O43639,Q13191,Q99704 264 1.24e-03 1416 4 4 1.000 0.003 GO:0007166 BP 1 cell surface receptor signaling pathway 1 O43639,Q13191,Q99704,A6NGB9 264 1.59e-03 81 4 2 0.500 0.025 GO:0030833 BP 1 regulation of actin filament polymerization 1 O43639,A6NGB9 264 2.10e-03 93 4 2 0.500 0.022 GO:0008064 BP 1 regulation of actin polymerization or depolymerization 1 O43639,A6NGB9 264 2.14e-03 94 4 2 0.500 0.021 GO:0030832 BP 1 regulation of actin filament length 1 O43639,A6NGB9 264 2.14e-03 94 4 2 0.500 0.021 GO:0030041 BP 1 actin filament polymerization 1 O43639,A6NGB9 264 2.28e-03 97 4 2 0.500 0.021 GO:0050730 BP 1 regulation of peptidyl-tyrosine phosphorylation 1 O43639,Q13191 264 2.38e-03 99 4 2 0.500 0.020 GO:0032271 BP 1 regulation of protein polymerization 1 O43639,A6NGB9 264 2.86e-03 593 4 3 0.750 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 O43639,Q13191,Q99704 264 2.94e-03 110 4 2 0.500 0.018 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 O43639,A6NGB9 264 3.32e-03 117 4 2 0.500 0.017 GO:0008154 BP 1 actin polymerization or depolymerization 1 O43639,A6NGB9 264 4.82e-03 141 4 2 0.500 0.014 GO:0018108 BP 1 peptidyl-tyrosine phosphorylation 1 O43639,Q13191 264 4.95e-03 143 4 2 0.500 0.014 GO:0031334 BP 1 positive regulation of protein complex assembly 1 O43639,A6NGB9 264 4.95e-03 143 4 2 0.500 0.014 GO:0018212 BP 1 peptidyl-tyrosine modification 1 O43639,Q13191 264 5.45e-03 150 4 2 0.500 0.013 GO:0051258 BP 1 protein polymerization 1 O43639,A6NGB9 264 5.72e-03 3 4 1 0.250 0.333 GO:0051666 BP 1 actin cortical patch localization 1 A6NGB9 264 5.72e-03 3 4 1 0.250 0.333 GO:0044396 BP 1 actin cortical patch organization 1 A6NGB9 264 5.72e-03 3 4 1 0.250 0.333 GO:0061645 CC 1 endocytic patch 1 A6NGB9 264 5.72e-03 3 4 1 0.250 0.333 GO:1903912 BP 1 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 1 O43639 264 5.72e-03 3 4 1 0.250 0.333 GO:0000147 BP 1 actin cortical patch assembly 1 A6NGB9 264 5.72e-03 3 4 1 0.250 0.333 GO:0030479 CC 1 actin cortical patch 1 A6NGB9 264 6.04e-03 2101 4 4 1.000 0.002 GO:0048583 BP 1 regulation of response to stimulus 1 O43639,Q13191,Q99704,A6NGB9 264 6.30e-03 80 4 2 0.500 0.025 KEGG:04012 keg 1 ErbB signaling pathway 1 O43639,Q13191 264 6.94e-03 84 4 2 0.500 0.024 KEGG:04660 keg 1 T cell receptor signaling pathway 1 O43639,Q13191 264 6.99e-03 170 4 2 0.500 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 O43639,A6NGB9 264 7.49e-03 176 4 2 0.500 0.011 GO:0032535 BP 1 regulation of cellular component size 1 O43639,A6NGB9 264 8.99e-03 193 4 2 0.500 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 O43639,A6NGB9 264 9.43e-03 98 4 2 0.500 0.020 KEGG:05162 keg 1 Measles 1 Q13191,Q99704 264 9.53e-03 5 4 1 0.250 0.200 GO:0036492 BP 1 eiF2alpha phosphorylation in response to endoplasmic reticulum stress 1 O43639 264 9.53e-03 5 4 1 0.250 0.200 GO:0036491 BP 1 regulation of translation initiation in response to endoplasmic reticulum stress 1 O43639 264 1.08e-02 212 4 2 0.500 0.009 GO:0007015 BP 1 actin filament organization 1 O43639,A6NGB9 264 1.11e-02 215 4 2 0.500 0.009 GO:0090066 BP 1 regulation of anatomical structure size 1 O43639,A6NGB9 264 1.14e-02 6 4 1 0.250 0.167 GO:0007175 BP 1 negative regulation of epidermal growth factor-activated receptor activity 1 Q13191 264 1.14e-02 6 4 1 0.250 0.167 GO:0036490 BP 1 regulation of translation in response to endoplasmic reticulum stress 1 O43639 264 1.19e-02 222 4 2 0.500 0.009 GO:0001933 BP 1 negative regulation of protein phosphorylation 1 O43639,Q13191 264 1.26e-02 229 4 2 0.500 0.009 GO:0043254 BP 1 regulation of protein complex assembly 1 O43639,A6NGB9 264 1.33e-02 7 4 1 0.250 0.143 GO:0007172 BP 1 signal complex assembly 1 O43639 264 1.33e-02 7 4 1 0.250 0.143 GO:0010998 BP 1 regulation of translational initiation by eIF2 alpha phosphorylation 1 O43639 264 1.45e-02 246 4 2 0.500 0.008 GO:0042326 BP 1 negative regulation of phosphorylation 1 O43639,Q13191 264 1.60e-02 7 4 1 0.250 0.143 REAC:8849469 rea 1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1 Q99704 264 1.66e-02 2707 4 4 1.000 0.001 GO:0005829 CC 1 cytosol 1 O43639,Q13191,Q99704,A6NGB9 264 1.67e-02 264 4 2 0.500 0.008 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 O43639,A6NGB9 264 1.68e-02 265 4 2 0.500 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 O43639,A6NGB9 264 2.09e-02 11 4 1 0.250 0.091 GO:0051127 BP 1 positive regulation of actin nucleation 1 A6NGB9 264 2.28e-02 12 4 1 0.250 0.083 GO:0061099 BP 1 negative regulation of protein tyrosine kinase activity 1 Q13191 264 2.28e-02 12 4 1 0.250 0.083 GO:0043558 BP 1 regulation of translational initiation in response to stress 1 O43639 264 2.47e-02 322 4 2 0.500 0.006 GO:0045936 BP 1 negative regulation of phosphate metabolic process 1 O43639,Q13191 264 2.48e-02 323 4 2 0.500 0.006 GO:0010563 BP 1 negative regulation of phosphorus metabolic process 1 O43639,Q13191 264 2.53e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 O43639,Q13191,Q99704,A6NGB9 264 2.67e-02 14 4 1 0.250 0.071 GO:0008093 MF 1 cytoskeletal adaptor activity 1 O43639 264 2.86e-02 15 4 1 0.250 0.067 GO:0005086 MF 1 ARF guanyl-nucleotide exchange factor activity 1 O43639 264 3.04e-02 358 4 2 0.500 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 O43639,A6NGB9 264 3.04e-02 16 4 1 0.250 0.062 GO:0033137 BP 1 negative regulation of peptidyl-serine phosphorylation 1 O43639 264 3.04e-02 16 4 1 0.250 0.062 GO:0043555 BP 1 regulation of translation in response to stress 1 O43639 264 3.07e-02 360 4 2 0.500 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 O43639,A6NGB9 264 3.19e-02 14 4 1 0.250 0.071 REAC:428540 rea 1 Activation of Rac 1 O43639 264 3.23e-02 331 4 2 0.500 0.006 MI:hsa-miR-580 mi 1 MI:hsa-miR-580 1 O43639,Q99704 264 3.23e-02 17 4 1 0.250 0.059 GO:0045742 BP 1 positive regulation of epidermal growth factor receptor signaling pathway 1 Q99704 264 3.23e-02 17 4 1 0.250 0.059 GO:2000272 BP 1 negative regulation of receptor activity 1 Q13191 264 3.23e-02 17 4 1 0.250 0.059 GO:0030866 BP 1 cortical actin cytoskeleton organization 1 A6NGB9 264 3.24e-02 370 4 2 0.500 0.005 GO:0031400 BP 1 negative regulation of protein modification process 1 O43639,Q13191 264 3.42e-02 18 4 1 0.250 0.056 GO:0030159 MF 1 receptor signaling complex scaffold activity 1 O43639 264 3.42e-02 18 4 1 0.250 0.056 GO:1901186 BP 1 positive regulation of ERBB signaling pathway 1 Q99704 264 3.47e-02 4659 4 4 1.000 0.001 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 O43639,Q13191,Q99704,A6NGB9 264 3.50e-02 872 4 2 0.500 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 O43639,A6NGB9 264 3.51e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 O43639,Q13191,Q99704,A6NGB9 264 3.54e-02 4682 4 4 1.000 0.001 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 O43639,Q13191,Q99704,A6NGB9 264 3.54e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 O43639,Q13191,Q99704,A6NGB9 264 3.56e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 O43639,Q13191,Q99704,A6NGB9 264 3.61e-02 391 4 2 0.500 0.005 GO:0043623 BP 1 cellular protein complex assembly 1 O43639,A6NGB9 264 3.61e-02 19 4 1 0.250 0.053 GO:0051125 BP 1 regulation of actin nucleation 1 A6NGB9 264 3.75e-02 3 4 1 0.250 0.333 CORUM:5171 cor 1 SH3KBP1-CBLB-EGFR complex 1 Q13191 264 3.80e-02 360 4 2 0.500 0.006 MI:mmu-miR-692 mi 1 MI:mmu-miR-692 1 Q13191,Q99704 264 3.82e-02 402 4 2 0.500 0.005 GO:0045859 BP 1 regulation of protein kinase activity 1 O43639,Q13191 264 3.87e-02 17 4 1 0.250 0.059 REAC:3928664 rea 1 Ephrin signaling 1 O43639 264 3.99e-02 21 4 1 0.250 0.048 GO:0006607 BP 1 NLS-bearing protein import into nucleus 1 Q13191 264 3.99e-02 21 4 1 0.250 0.048 GO:0030865 BP 1 cortical cytoskeleton organization 1 A6NGB9 264 4.14e-02 419 4 2 0.500 0.005 GO:0030029 BP 1 actin filament-based process 1 O43639,A6NGB9 264 4.53e-02 439 4 2 0.500 0.005 GO:0043549 BP 1 regulation of kinase activity 1 O43639,Q13191 264 4.93e-02 411 4 2 0.500 0.005 MI:hsa-miR-92a mi 1 MI:hsa-miR-92a 1 O43639,Q99704 264 4.94e-02 26 4 1 0.250 0.038 GO:1903573 BP 1 negative regulation of response to endoplasmic reticulum stress 1 O43639 264 5.00e-02 4 4 1 0.250 0.250 CORUM:2453 cor 1 Multiprotein complex (monoubiquitination) 1 Q13191 264 5.00e-02 22 4 1 0.250 0.045 REAC:373753 rea 1 Nephrin interactions 1 O43639 264 5.00e-02 45 4 2 0.500 0.044 TF:M06556_0 tf 1 Factor: znf383; motif: KGGAAGGTAAGC; match class: 0 1 Q13191,Q99704 264 5.00e-02 229 4 2 0.500 0.009 KEGG:04144 keg 1 Endocytosis 1 Q13191,A6NGB9 264 5.00e-02 414 4 2 0.500 0.005 MI:hsa-miR-631 mi 1 MI:hsa-miR-631 1 Q13191,Q99704 264 5.00e-02 1573 4 3 0.750 0.002 GO:0009966 BP 1 regulation of signal transduction 1 O43639,Q13191,Q99704 265 2.51e-11 4 3 3 1.000 0.750 GO:0004740 MF 1 pyruvate dehydrogenase (acetyl-transferring) kinase activity 1 Q15119,Q15120,Q15118 265 1.38e-09 12 3 3 1.000 0.250 GO:0050812 BP 1 regulation of acyl-CoA biosynthetic process 1 Q15119,Q15120,Q15118 265 1.38e-09 12 3 3 1.000 0.250 GO:0006086 BP 1 acetyl-CoA biosynthetic process from pyruvate 1 Q15119,Q15120,Q15118 265 1.38e-09 12 3 3 1.000 0.250 GO:0010510 BP 1 regulation of acetyl-CoA biosynthetic process from pyruvate 1 Q15119,Q15120,Q15118 265 3.52e-09 16 3 3 1.000 0.188 GO:0006085 BP 1 acetyl-CoA biosynthetic process 1 Q15119,Q15120,Q15118 265 4.27e-09 17 3 3 1.000 0.176 GO:0042762 BP 1 regulation of sulfur metabolic process 1 Q15119,Q15120,Q15118 265 9.67e-09 22 3 3 1.000 0.136 GO:0006084 BP 1 acetyl-CoA metabolic process 1 Q15119,Q15120,Q15118 265 2.16e-08 14 3 3 1.000 0.214 REAC:204174 rea 1 Regulation of pyruvate dehydrogenase (PDH) complex 1 Q15119,Q15120,Q15118 265 5.74e-08 39 3 3 1.000 0.077 GO:0051193 BP 1 regulation of cofactor metabolic process 1 Q15119,Q15120,Q15118 265 5.74e-08 39 3 3 1.000 0.077 GO:0051196 BP 1 regulation of coenzyme metabolic process 1 Q15119,Q15120,Q15118 265 8.91e-08 45 3 3 1.000 0.067 GO:0010906 BP 1 regulation of glucose metabolic process 1 Q15119,Q15120,Q15118 265 8.91e-08 45 3 3 1.000 0.067 GO:0019217 BP 1 regulation of fatty acid metabolic process 1 Q15119,Q15120,Q15118 265 1.16e-07 49 3 3 1.000 0.061 GO:0071616 BP 1 acyl-CoA biosynthetic process 1 Q15119,Q15120,Q15118 265 1.16e-07 49 3 3 1.000 0.061 GO:0035384 BP 1 thioester biosynthetic process 1 Q15119,Q15120,Q15118 265 1.54e-07 26 3 3 1.000 0.115 REAC:70268 rea 1 Pyruvate metabolism 1 Q15119,Q15120,Q15118 265 2.04e-07 59 3 3 1.000 0.051 GO:0010675 BP 1 regulation of cellular carbohydrate metabolic process 1 Q15119,Q15120,Q15118 265 2.17e-07 3 3 2 0.667 0.667 GO:0097411 BP 1 hypoxia-inducible factor-1alpha signaling pathway 1 Q15120,Q15118 265 2.74e-07 65 3 3 1.000 0.046 GO:0006637 BP 1 acyl-CoA metabolic process 1 Q15119,Q15120,Q15118 265 2.74e-07 65 3 3 1.000 0.046 GO:0035383 BP 1 thioester metabolic process 1 Q15119,Q15120,Q15118 265 3.55e-07 34 3 3 1.000 0.088 REAC:5362517 rea 1 Signaling by Retinoic Acid 1 Q15119,Q15120,Q15118 265 4.41e-07 76 3 3 1.000 0.039 GO:0006090 BP 1 pyruvate metabolic process 1 Q15119,Q15120,Q15118 265 4.59e-07 77 3 3 1.000 0.039 GO:0006109 BP 1 regulation of carbohydrate metabolic process 1 Q15119,Q15120,Q15118 265 7.88e-07 92 3 3 1.000 0.033 GO:0009108 BP 1 coenzyme biosynthetic process 1 Q15119,Q15120,Q15118 265 9.00e-07 46 3 3 1.000 0.065 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 Q15119,Q15120,Q15118 265 1.28e-06 108 3 3 1.000 0.028 GO:0010565 BP 1 regulation of cellular ketone metabolic process 1 Q15119,Q15120,Q15118 265 1.35e-06 110 3 3 1.000 0.027 GO:0006006 BP 1 glucose metabolic process 1 Q15119,Q15120,Q15118 265 1.90e-06 123 3 3 1.000 0.024 GO:0051188 BP 1 cofactor biosynthetic process 1 Q15119,Q15120,Q15118 265 2.04e-06 126 3 3 1.000 0.024 GO:0044262 BP 1 cellular carbohydrate metabolic process 1 Q15119,Q15120,Q15118 265 2.63e-06 137 3 3 1.000 0.022 GO:0019318 BP 1 hexose metabolic process 1 Q15119,Q15120,Q15118 265 2.93e-06 142 3 3 1.000 0.021 GO:0042180 BP 1 cellular ketone metabolic process 1 Q15119,Q15120,Q15118 265 3.26e-06 147 3 3 1.000 0.020 GO:0019216 BP 1 regulation of lipid metabolic process 1 Q15119,Q15120,Q15118 265 4.45e-06 163 3 3 1.000 0.018 GO:0044272 BP 1 sulfur compound biosynthetic process 1 Q15119,Q15120,Q15118 265 5.05e-06 170 3 3 1.000 0.018 GO:0005996 BP 1 monosaccharide metabolic process 1 Q15119,Q15120,Q15118 265 8.62e-06 203 3 3 1.000 0.015 GO:0006631 BP 1 fatty acid metabolic process 1 Q15119,Q15120,Q15118 265 1.01e-05 214 3 3 1.000 0.014 GO:0006732 BP 1 coenzyme metabolic process 1 Q15119,Q15120,Q15118 265 1.97e-05 267 3 3 1.000 0.011 GO:0051186 BP 1 cofactor metabolic process 1 Q15119,Q15120,Q15118 265 2.20e-05 277 3 3 1.000 0.011 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 Q15119,Q15120,Q15118 265 2.45e-05 287 3 3 1.000 0.010 GO:0006790 BP 1 sulfur compound metabolic process 1 Q15119,Q15120,Q15118 265 3.47e-05 153 3 3 1.000 0.020 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 Q15119,Q15120,Q15118 265 3.53e-05 324 3 3 1.000 0.009 GO:0005975 BP 1 carbohydrate metabolic process 1 Q15119,Q15120,Q15118 265 4.22e-05 344 3 3 1.000 0.009 GO:0005759 CC 1 mitochondrial matrix 1 Q15119,Q15120,Q15118 265 4.56e-05 353 3 3 1.000 0.008 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 Q15119,Q15120,Q15118 265 1.09e-04 472 3 3 1.000 0.006 GO:0004672 MF 1 protein kinase activity 1 Q15119,Q15120,Q15118 265 1.84e-04 72 3 2 0.667 0.028 GO:0071456 BP 1 cellular response to hypoxia 1 Q15120,Q15118 265 2.00e-04 75 3 2 0.667 0.027 GO:0036294 BP 1 cellular response to decreased oxygen levels 1 Q15120,Q15118 265 2.01e-04 578 3 3 1.000 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 Q15119,Q15120,Q15118 265 2.22e-04 79 3 2 0.667 0.025 GO:0071453 BP 1 cellular response to oxygen levels 1 Q15120,Q15118 265 2.28e-04 80 3 2 0.667 0.025 GO:0042593 BP 1 glucose homeostasis 1 Q15119,Q15120 265 2.28e-04 80 3 2 0.667 0.025 GO:0033500 BP 1 carbohydrate homeostasis 1 Q15119,Q15120 265 2.60e-04 630 3 3 1.000 0.005 GO:0016301 MF 1 kinase activity 1 Q15119,Q15120,Q15118 265 2.64e-04 633 3 3 1.000 0.005 GO:0044255 BP 1 cellular lipid metabolic process 1 Q15119,Q15120,Q15118 265 2.86e-04 650 3 3 1.000 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q15119,Q15120,Q15118 265 3.19e-04 674 3 3 1.000 0.004 GO:0044429 CC 1 mitochondrial part 1 Q15119,Q15120,Q15118 265 4.04e-04 729 3 3 1.000 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 Q15119,Q15120,Q15118 265 4.21e-04 739 3 3 1.000 0.004 GO:0006082 BP 1 organic acid metabolic process 1 Q15119,Q15120,Q15118 265 4.49e-04 755 3 3 1.000 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q15119,Q15120,Q15118 265 4.67e-04 765 3 3 1.000 0.004 GO:0006629 BP 1 lipid metabolic process 1 Q15119,Q15120,Q15118 265 4.72e-04 115 3 2 0.667 0.017 GO:0001666 BP 1 response to hypoxia 1 Q15120,Q15118 265 4.96e-04 118 3 2 0.667 0.017 GO:0036293 BP 1 response to decreased oxygen levels 1 Q15120,Q15118 265 5.31e-04 122 3 2 0.667 0.016 GO:0034599 BP 1 cellular response to oxidative stress 1 Q15119,Q15118 265 5.31e-04 122 3 2 0.667 0.016 GO:0070482 BP 1 response to oxygen levels 1 Q15120,Q15118 265 6.43e-04 851 3 3 1.000 0.004 GO:0044711 BP 1 single-organism biosynthetic process 1 Q15119,Q15120,Q15118 265 7.53e-04 897 3 3 1.000 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 Q15119,Q15120,Q15118 265 8.35e-04 2 3 1 0.333 0.500 GO:0005967 CC 1 mitochondrial pyruvate dehydrogenase complex 1 Q15119 265 1.02e-03 169 3 2 0.667 0.012 GO:0097193 BP 1 intrinsic apoptotic signaling pathway 1 Q15119,Q15118 265 1.14e-03 1029 3 3 1.000 0.003 GO:0005739 CC 1 mitochondrion 1 Q15119,Q15120,Q15118 265 1.35e-03 195 3 2 0.667 0.010 GO:0006979 BP 1 response to oxidative stress 1 Q15119,Q15118 265 1.86e-03 1212 3 3 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 Q15119,Q15120,Q15118 265 1.90e-03 231 3 2 0.667 0.009 GO:0005524 MF 1 ATP binding 1 Q15119,Q15120 265 2.31e-03 255 3 2 0.667 0.008 GO:0032559 MF 1 adenyl ribonucleotide binding 1 Q15119,Q15120 265 2.47e-03 1333 3 3 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 Q15119,Q15120,Q15118 265 2.49e-03 265 3 2 0.667 0.008 GO:0030554 MF 1 adenyl nucleotide binding 1 Q15119,Q15120 265 2.50e-03 6 3 1 0.333 0.167 GO:0045254 CC 1 pyruvate dehydrogenase complex 1 Q15119 265 3.01e-03 1423 3 3 1.000 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q15119,Q15120,Q15118 265 3.79e-03 327 3 2 0.667 0.006 GO:0035639 MF 1 purine ribonucleoside triphosphate binding 1 Q15119,Q15120 265 3.86e-03 330 3 2 0.667 0.006 GO:0097190 BP 1 apoptotic signaling pathway 1 Q15119,Q15118 265 4.17e-03 10 3 1 0.333 0.100 GO:0035357 BP 1 peroxisome proliferator activated receptor signaling pathway 1 Q15120 265 4.31e-03 349 3 2 0.667 0.006 GO:0032549 MF 1 ribonucleoside binding 1 Q15119,Q15120 265 4.31e-03 349 3 2 0.667 0.006 GO:0032550 MF 1 purine ribonucleoside binding 1 Q15119,Q15120 265 4.33e-03 350 3 2 0.667 0.006 GO:0001883 MF 1 purine nucleoside binding 1 Q15119,Q15120 265 4.41e-03 353 3 2 0.667 0.006 GO:0001882 MF 1 nucleoside binding 1 Q15119,Q15120 265 4.73e-03 366 3 2 0.667 0.005 GO:0032555 MF 1 purine ribonucleotide binding 1 Q15119,Q15120 265 4.89e-03 372 3 2 0.667 0.005 GO:0032553 MF 1 ribonucleotide binding 1 Q15119,Q15120 265 5.05e-03 378 3 2 0.667 0.005 GO:0017076 MF 1 purine nucleotide binding 1 Q15119,Q15120 265 5.27e-03 1715 3 3 1.000 0.002 GO:0016740 MF 1 transferase activity 1 Q15119,Q15120,Q15118 265 5.59e-03 291 3 2 0.667 0.007 TF:M07258_1 tf 1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 1 1 Q15119,Q15118 265 5.84e-03 14 3 1 0.333 0.071 GO:0031670 BP 1 cellular response to nutrient 1 Q15119 265 5.84e-03 14 3 1 0.333 0.071 GO:0071398 BP 1 cellular response to fatty acid 1 Q15120 265 6.26e-03 15 3 1 0.333 0.067 GO:0070542 BP 1 response to fatty acid 1 Q15120 265 6.67e-03 16 3 1 0.333 0.062 GO:0006111 BP 1 regulation of gluconeogenesis 1 Q15119 265 6.94e-03 444 3 2 0.667 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 Q15119,Q15120 265 6.96e-03 1882 3 3 1.000 0.002 GO:0042221 BP 1 response to chemical 1 Q15119,Q15120,Q15118 265 7.43e-03 1923 3 3 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 Q15119,Q15120,Q15118 265 8.06e-03 479 3 2 0.667 0.004 GO:0000166 MF 1 nucleotide binding 1 Q15119,Q15120 265 8.09e-03 480 3 2 0.667 0.004 GO:1901265 MF 1 nucleoside phosphate binding 1 Q15119,Q15120 265 8.23e-03 1673 3 3 1.000 0.002 TF:M07302_0 tf 1 Factor: NF-Y; motif: RGCCAATCRGN; match class: 0 1 Q15119,Q15120,Q15118 265 8.90e-03 368 3 2 0.667 0.005 TF:M05704_0 tf 1 Factor: ZNF133; motif: NGGTTAAACNSM; match class: 0 1 Q15120,Q15118 265 9.19e-03 512 3 2 0.667 0.004 GO:0048878 BP 1 chemical homeostasis 1 Q15119,Q15120 265 9.24e-03 2068 3 3 1.000 0.001 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q15119,Q15120,Q15118 265 9.28e-03 2071 3 3 1.000 0.001 GO:0006950 BP 1 response to stress 1 Q15119,Q15120,Q15118 265 9.44e-03 519 3 2 0.667 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 Q15120,Q15118 265 9.54e-03 2090 3 3 1.000 0.001 GO:0009889 BP 1 regulation of biosynthetic process 1 Q15119,Q15120,Q15118 265 1.02e-02 540 3 2 0.667 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 Q15119,Q15120 265 1.08e-02 26 3 1 0.333 0.038 GO:0007584 BP 1 response to nutrient 1 Q15119 265 1.20e-02 586 3 2 0.667 0.003 GO:1901700 BP 1 response to oxygen-containing compound 1 Q15119,Q15120 265 1.27e-02 1933 3 3 1.000 0.002 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 Q15119,Q15120,Q15118 265 1.29e-02 31 3 1 0.333 0.032 GO:0071333 BP 1 cellular response to glucose stimulus 1 Q15120 265 1.29e-02 31 3 1 0.333 0.032 GO:0008631 BP 1 intrinsic apoptotic signaling pathway in response to oxidative stress 1 Q15118 265 1.31e-02 612 3 2 0.667 0.003 GO:0036094 MF 1 small molecule binding 1 Q15119,Q15120 265 1.37e-02 33 3 1 0.333 0.030 GO:0071326 BP 1 cellular response to monosaccharide stimulus 1 Q15120 265 1.37e-02 33 3 1 0.333 0.030 GO:0071331 BP 1 cellular response to hexose stimulus 1 Q15120 265 1.46e-02 35 3 1 0.333 0.029 GO:0071322 BP 1 cellular response to carbohydrate stimulus 1 Q15120 265 1.54e-02 18 3 1 0.333 0.056 TF:M04116_1 tf 1 Factor: EOMES; motif: TCACACCTNNNNAGGTGTGA; match class: 1 1 Q15119 265 1.66e-02 40 3 1 0.333 0.025 GO:0043255 BP 1 regulation of carbohydrate biosynthetic process 1 Q15119 265 1.67e-02 1 3 1 0.333 1.000 OMIM:300905 omi 1 CHARCOT-MARIE-TOOTH DISEASE, X-LINKED DOMINANT, 6; CMTX6;;CHARCOT-MARIE-TOOTH NEUROPATHY, X-LINKED DOMINANT, 6 1 Q15120 265 1.72e-02 2140 3 3 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 Q15119,Q15120,Q15118 265 1.75e-02 2560 3 3 1.000 0.001 GO:0044710 BP 1 single-organism metabolic process 1 Q15119,Q15120,Q15118 265 1.79e-02 43 3 1 0.333 0.023 GO:0072332 BP 1 intrinsic apoptotic signaling pathway by p53 class mediator 1 Q15119 265 1.79e-02 43 3 1 0.333 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 Q15120 265 1.83e-02 44 3 1 0.333 0.023 GO:0036473 BP 1 cell death in response to oxidative stress 1 Q15118 265 2.08e-02 50 3 1 0.333 0.020 GO:0009749 BP 1 response to glucose 1 Q15120 265 2.12e-02 783 3 2 0.667 0.003 GO:0042592 BP 1 homeostatic process 1 Q15119,Q15120 265 2.12e-02 51 3 1 0.333 0.020 GO:0006094 BP 1 gluconeogenesis 1 Q15119 265 2.20e-02 53 3 1 0.333 0.019 GO:0009746 BP 1 response to hexose 1 Q15120 265 2.20e-02 53 3 1 0.333 0.019 GO:0034284 BP 1 response to monosaccharide 1 Q15120 265 2.24e-02 54 3 1 0.333 0.019 GO:0019319 BP 1 hexose biosynthetic process 1 Q15119 265 2.33e-02 56 3 1 0.333 0.018 GO:0009743 BP 1 response to carbohydrate 1 Q15120 265 2.35e-02 826 3 2 0.667 0.002 GO:0043168 MF 1 anion binding 1 Q15119,Q15120 265 2.41e-02 58 3 1 0.333 0.017 GO:0046364 BP 1 monosaccharide biosynthetic process 1 Q15119 265 2.53e-02 61 3 1 0.333 0.016 GO:0006885 BP 1 regulation of pH 1 Q15119 265 2.70e-02 65 3 1 0.333 0.015 GO:0034614 BP 1 cellular response to reactive oxygen species 1 Q15119 265 2.74e-02 2497 3 3 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q15119,Q15120,Q15118 265 2.81e-02 2997 3 3 1.000 0.001 GO:0080090 BP 1 regulation of primary metabolic process 1 Q15119,Q15120,Q15118 265 2.83e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 Q15119,Q15120,Q15118 265 2.88e-02 3022 3 3 1.000 0.001 GO:0031323 BP 1 regulation of cellular metabolic process 1 Q15119,Q15120,Q15118 265 2.92e-02 671 3 2 0.667 0.003 TF:M00531_1 tf 1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 1 1 Q15119,Q15120 265 3.00e-02 936 3 2 0.667 0.002 GO:0006915 BP 1 apoptotic process 1 Q15119,Q15118 265 3.07e-02 74 3 1 0.333 0.014 GO:0071229 BP 1 cellular response to acid chemical 1 Q15120 265 3.12e-02 956 3 2 0.667 0.002 GO:0012501 BP 1 programmed cell death 1 Q15119,Q15118 265 3.24e-02 78 3 1 0.333 0.013 GO:2000377 BP 1 regulation of reactive oxygen species metabolic process 1 Q15120 265 3.24e-02 78 3 1 0.333 0.013 GO:1990204 CC 1 oxidoreductase complex 1 Q15119 265 3.28e-02 79 3 1 0.333 0.013 GO:0008286 BP 1 insulin receptor signaling pathway 1 Q15119 265 3.41e-02 40 3 1 0.333 0.025 TF:M03939_1 tf 1 Factor: ZNF740; motif: CCCCCCCCAC; match class: 1 1 Q15119 265 3.44e-02 83 3 1 0.333 0.012 GO:0031669 BP 1 cellular response to nutrient levels 1 Q15119 265 3.48e-02 84 3 1 0.333 0.012 GO:0055067 BP 1 monovalent inorganic cation homeostasis 1 Q15119 265 3.51e-02 2712 3 3 1.000 0.001 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 Q15119,Q15120,Q15118 265 3.60e-02 1029 3 2 0.667 0.002 GO:0008219 BP 1 cell death 1 Q15119,Q15118 265 3.63e-02 3262 3 3 1.000 0.001 GO:0007154 BP 1 cell communication 1 Q15119,Q15120,Q15118 265 3.63e-02 3263 3 3 1.000 0.001 GO:0019222 BP 1 regulation of metabolic process 1 Q15119,Q15120,Q15118 265 3.65e-02 3268 3 3 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 Q15119,Q15120,Q15118 265 3.67e-02 3274 3 3 1.000 0.001 GO:0023052 BP 1 signaling 1 Q15119,Q15120,Q15118 265 3.75e-02 64 3 1 0.333 0.016 KEGG:05230 keg 1 Central carbon metabolism in cancer 1 Q15118 265 3.77e-02 91 3 1 0.333 0.011 GO:0031668 BP 1 cellular response to extracellular stimulus 1 Q15119 265 3.85e-02 1575 3 3 1.000 0.002 REAC:162582 rea 1 Signal Transduction 1 Q15119,Q15120,Q15118 265 3.85e-02 93 3 1 0.333 0.011 GO:0001101 BP 1 response to acid chemical 1 Q15120 265 3.89e-02 2808 3 3 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q15119,Q15120,Q15118 265 4.06e-02 98 3 1 0.333 0.010 GO:0000302 BP 1 response to reactive oxygen species 1 Q15119 265 4.09e-02 48 3 1 0.333 0.021 TF:M04116_0 tf 1 Factor: EOMES; motif: TCACACCTNNNNAGGTGTGA; match class: 0 1 Q15119 265 4.45e-02 2935 3 3 1.000 0.001 TF:M01889_1 tf 1 Factor: Smad4; motif: TGTCTGN; match class: 1 1 Q15119,Q15120,Q15118 265 4.47e-02 108 3 1 0.333 0.009 GO:0031667 BP 1 response to nutrient levels 1 Q15119 265 4.48e-02 3499 3 3 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 Q15119,Q15120,Q15118 265 4.51e-02 109 3 1 0.333 0.009 GO:0032869 BP 1 cellular response to insulin stimulus 1 Q15119 265 4.52e-02 1157 3 2 0.667 0.002 GO:0071310 BP 1 cellular response to organic substance 1 Q15119,Q15120 265 4.71e-02 114 3 1 0.333 0.009 GO:0032868 BP 1 response to insulin 1 Q15119 265 4.72e-02 3561 3 3 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q15119,Q15120,Q15118 265 4.72e-02 3561 3 3 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q15119,Q15120,Q15118 265 4.72e-02 3561 3 3 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 Q15119,Q15120,Q15118 265 4.75e-02 3569 3 3 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 Q15119,Q15120,Q15118 265 4.75e-02 115 3 1 0.333 0.009 GO:0016051 BP 1 carbohydrate biosynthetic process 1 Q15119 265 4.92e-02 119 3 1 0.333 0.008 GO:0071496 BP 1 cellular response to external stimulus 1 Q15119 265 4.92e-02 119 3 1 0.333 0.008 GO:0009991 BP 1 response to extracellular stimulus 1 Q15119 265 4.96e-02 3620 3 3 1.000 0.001 GO:0009058 BP 1 biosynthetic process 1 Q15119,Q15120,Q15118 265 5.00e-02 121 3 1 0.333 0.008 GO:0072593 BP 1 reactive oxygen species metabolic process 1 Q15120 265 5.00e-02 3 3 1 0.333 0.333 OMIM:302800 omi 1 X-linked Charcot-Marie-Tooth Disease 1 Q15120 265 5.00e-02 2 3 1 0.333 0.500 HP:0002378 hp 1 Hand tremor 1 Q15120 265 5.00e-02 308 3 2 0.667 0.006 MI:hsa-miR-432* mi 1 MI:hsa-miR-432* 1 Q15119,Q15120 265 5.00e-02 3052 3 3 1.000 0.001 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q15119,Q15120,Q15118 265 5.00e-02 1718 3 3 1.000 0.002 REAC:1430728 rea 1 Metabolism 1 Q15119,Q15120,Q15118 266 2.51e-03 244 2 2 1.000 0.008 TF:M00514_1 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 1 1 Q15293,Q86Y79 266 5.39e-03 5 2 1 0.500 0.200 TF:M06287_0 tf 1 Factor: ZNF791; motif: KGTTGCATGAGA; match class: 0 1 Q15293 266 9.98e-03 486 2 2 1.000 0.004 TF:M00178_1 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 1 1 Q15293,Q86Y79 266 1.01e-02 488 2 2 1.000 0.004 TF:M00338_1 tf 1 Factor: ATF; motif: NTGACGTCANYS; match class: 1 1 Q15293,Q86Y79 266 1.29e-02 12 2 1 0.500 0.083 TF:M01830_1 tf 1 Factor: MAX; motif: CNNGMCACGTGN; match class: 1 1 Q86Y79 266 1.50e-02 595 2 2 1.000 0.003 TF:M00765_1 tf 1 Factor: COUP; motif: TGACCTTTGACCC; match class: 1 1 Q15293,Q86Y79 266 1.62e-02 15 2 1 0.500 0.067 TF:M05745_0 tf 1 Factor: ZNF718; motif: NGGGRATWGCGM; match class: 0 1 Q15293 266 2.03e-02 692 2 2 1.000 0.003 TF:M01652_1 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 1 1 Q15293,Q86Y79 266 2.26e-02 21 2 1 0.500 0.048 TF:M06850_1 tf 1 Factor: ZNF96; motif: NGGWRCGGAGGA; match class: 1 1 Q15293 266 2.59e-02 782 2 2 1.000 0.003 TF:M01863_1 tf 1 Factor: ATF-3; motif: RTKRCGTCANN; match class: 1 1 Q15293,Q86Y79 266 2.71e-02 800 2 2 1.000 0.003 TF:M01864_1 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 1 1 Q15293,Q86Y79 266 2.91e-02 27 2 1 0.500 0.037 TF:M00011_1 tf 1 Factor: Evi-1; motif: ACAAGATAA; match class: 1 1 Q15293 266 3.07e-02 852 2 2 1.000 0.002 TF:M00039_1 tf 1 Factor: CREB; motif: TGACGTMA; match class: 1 1 Q15293,Q86Y79 266 3.07e-02 852 2 2 1.000 0.002 TF:M00039_0 tf 1 Factor: CREB; motif: TGACGTMA; match class: 0 1 Q15293,Q86Y79 266 3.12e-02 29 2 1 0.500 0.034 TF:M06415_0 tf 1 Factor: ZNF429; motif: NMGTCGGGMCGC; match class: 0 1 Q15293 266 3.13e-02 860 2 2 1.000 0.002 TF:M00041_1 tf 1 Factor: ATF2:c-Jun; motif: TGACGTYA; match class: 1 1 Q15293,Q86Y79 266 3.36e-02 891 2 2 1.000 0.002 TF:M07312_1 tf 1 Factor: ATF-2; motif: NNTGACGTCAN; match class: 1 1 Q15293,Q86Y79 266 3.39e-02 895 2 2 1.000 0.002 TF:M00338_0 tf 1 Factor: ATF; motif: NTGACGTCANYS; match class: 0 1 Q15293,Q86Y79 266 3.74e-02 940 2 2 1.000 0.002 TF:M00513_1 tf 1 Factor: ATF3; motif: CBCTGACGTCANCS; match class: 1 1 Q15293,Q86Y79 266 3.82e-02 950 2 2 1.000 0.002 TF:M02279_1 tf 1 Factor: CREB1; motif: TGACGTCA; match class: 1 1 Q15293,Q86Y79 266 4.09e-02 38 2 1 0.500 0.026 TF:M06323_0 tf 1 Factor: ZNF569; motif: NGRTTAAGAATC; match class: 0 1 Q15293 266 4.22e-02 999 2 2 1.000 0.002 TF:M04594_0 tf 1 Factor: Zic3; motif: CCCGCTGGG; match class: 0 1 Q15293,Q86Y79 266 4.52e-02 42 2 1 0.500 0.024 TF:M03838_1 tf 1 Factor: Otx1; motif: WASTAATCC; match class: 1 1 Q86Y79 266 4.77e-02 1062 2 2 1.000 0.002 TF:M07209_0 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 0 1 Q15293,Q86Y79 266 4.84e-02 45 2 1 0.500 0.022 TF:M06083_0 tf 1 Factor: ZNF891; motif: NGGGGCATAASA; match class: 0 1 Q86Y79 266 4.84e-02 45 2 1 0.500 0.022 TF:M06219_0 tf 1 Factor: ZNF266; motif: NGGWAAGTCCGY; match class: 0 1 Q15293 266 5.00e-02 381 2 2 1.000 0.005 MI:hsa-miR-622 mi 1 MI:hsa-miR-622 1 Q15293,Q86Y79 266 5.00e-02 1087 2 2 1.000 0.002 TF:M00178_0 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 0 1 Q15293,Q86Y79 266 5.00e-02 1087 2 2 1.000 0.002 TF:M01861_1 tf 1 Factor: ATF-1; motif: TNACGTCAN; match class: 1 1 Q15293,Q86Y79 266 5.00e-02 3 2 1 0.500 0.333 GO:0004045 MF 1 aminoacyl-tRNA hydrolase activity 1 Q86Y79 267 1.00e-03 1 2 1 0.500 1.000 GO:0034441 BP 1 plasma lipoprotein particle oxidation 1 Q13093 267 1.00e-03 1 2 1 0.500 1.000 GO:1904692 BP 1 positive regulation of type B pancreatic cell proliferation 1 Q16849 267 1.10e-03 7 2 1 0.500 0.143 TF:M00325_0 tf 1 Factor: NRSE; motif: TTYAGCWCCDCGGASAGYRCC; match class: 0 1 Q16849 267 2.00e-03 2 2 1 0.500 0.500 GO:0003847 MF 1 1-alkyl-2-acetylglycerophosphocholine esterase activity 1 Q13093 267 2.00e-03 2 2 1 0.500 0.500 GO:1990502 BP 1 dense core granule maturation 1 Q16849 267 2.00e-03 2 2 1 0.500 0.500 GO:0042161 BP 1 lipoprotein oxidation 1 Q13093 267 2.00e-03 2 2 1 0.500 0.500 GO:0061469 BP 1 regulation of type B pancreatic cell proliferation 1 Q16849 267 2.00e-03 2 2 1 0.500 0.500 GO:0042160 BP 1 lipoprotein modification 1 Q13093 267 2.00e-03 2 2 1 0.500 0.500 GO:0061792 BP 1 secretory granule maturation 1 Q16849 267 3.01e-03 3 2 1 0.500 0.333 GO:0001553 BP 1 luteinization 1 Q16849 267 3.01e-03 3 2 1 0.500 0.333 GO:0047499 MF 1 calcium-independent phospholipase A2 activity 1 Q13093 267 3.14e-03 20 2 1 0.500 0.050 TF:M00248_0 tf 1 Factor: Oct-1; motif: TNTATGBTAATT; match class: 0 1 Q16849 267 3.30e-03 732 2 2 1.000 0.003 TF:M00205_1 tf 1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1 1 Q16849,Q13093 267 4.01e-03 4 2 1 0.500 0.250 GO:0034362 CC 1 low-density lipoprotein particle 1 Q13093 267 5.01e-03 5 2 1 0.500 0.200 GO:0046469 BP 1 platelet activating factor metabolic process 1 Q13093 267 5.01e-03 5 2 1 0.500 0.200 GO:0044342 BP 1 type B pancreatic cell proliferation 1 Q16849 267 5.81e-03 37 2 1 0.500 0.027 TF:M00256_0 tf 1 Factor: NRSF; motif: TTCAGCACCACGGACAGMGCC; match class: 0 1 Q16849 267 5.83e-03 972 2 2 1.000 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q16849,Q13093 267 6.01e-03 6 2 1 0.500 0.167 GO:0034374 BP 1 low-density lipoprotein particle remodeling 1 Q13093 267 8.50e-03 10 2 1 0.500 0.100 REAC:422085 rea 1 Synthesis, secretion, and deacylation of Ghrelin 1 Q13093 267 8.62e-03 55 2 1 0.500 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q13093 267 9.02e-03 9 2 1 0.500 0.111 GO:0090026 BP 1 positive regulation of monocyte chemotaxis 1 Q13093 267 9.41e-03 60 2 1 0.500 0.017 TF:M01028_0 tf 1 Factor: NRSF; motif: GYRCTGTCCRYGGTGCTGA; match class: 0 1 Q16849 267 1.08e-02 69 2 1 0.500 0.014 TF:M01256_0 tf 1 Factor: REST; motif: NNNNGGNGCTGTCCATGGTGCT; match class: 0 1 Q16849 267 1.10e-02 504 2 2 1.000 0.004 GO:0016788 MF 1 hydrolase activity, acting on ester bonds 1 Q16849,Q13093 267 1.10e-02 11 2 1 0.500 0.091 GO:1990777 CC 1 lipoprotein particle 1 Q13093 267 1.10e-02 11 2 1 0.500 0.091 GO:0071677 BP 1 positive regulation of mononuclear cell migration 1 Q13093 267 1.10e-02 11 2 1 0.500 0.091 GO:0034358 CC 1 plasma lipoprotein particle 1 Q13093 267 1.13e-02 72 2 1 0.500 0.014 TF:M06363_0 tf 1 Factor: ZNF730; motif: NNGGTGGACCGC; match class: 0 1 Q13093 267 1.20e-02 12 2 1 0.500 0.083 GO:0034367 BP 1 macromolecular complex remodeling 1 Q13093 267 1.20e-02 12 2 1 0.500 0.083 GO:0090025 BP 1 regulation of monocyte chemotaxis 1 Q13093 267 1.20e-02 12 2 1 0.500 0.083 GO:0034368 BP 1 protein-lipid complex remodeling 1 Q13093 267 1.20e-02 12 2 1 0.500 0.083 GO:0034369 BP 1 plasma lipoprotein particle remodeling 1 Q13093 267 1.30e-02 13 2 1 0.500 0.077 GO:0033363 BP 1 secretory granule organization 1 Q16849 267 1.30e-02 13 2 1 0.500 0.077 GO:0032994 CC 1 protein-lipid complex 1 Q13093 267 1.50e-02 15 2 1 0.500 0.067 GO:0004623 MF 1 phospholipase A2 activity 1 Q13093 267 1.53e-02 98 2 1 0.500 0.010 TF:M02219_1 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 1 Q13093 267 1.58e-02 101 2 1 0.500 0.010 TF:M05833_0 tf 1 Factor: ZNF572; motif: NNKGRCTGTAGM; match class: 0 1 Q16849 267 1.60e-02 16 2 1 0.500 0.062 GO:0071675 BP 1 regulation of mononuclear cell migration 1 Q13093 267 1.67e-02 1 2 1 0.500 1.000 OMIM:614278 omi 1 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE DEFICIENCY; PAFAD 1 Q13093 267 1.67e-02 107 2 1 0.500 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 Q13093 267 1.74e-02 111 2 1 0.500 0.009 TF:M04197_0 tf 1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 0 1 Q16849 267 1.80e-02 18 2 1 0.500 0.056 GO:0046545 BP 1 development of primary female sexual characteristics 1 Q16849 267 1.80e-02 18 2 1 0.500 0.056 GO:0008585 BP 1 female gonad development 1 Q16849 267 1.80e-02 18 2 1 0.500 0.056 GO:0022602 BP 1 ovulation cycle process 1 Q16849 267 1.83e-02 117 2 1 0.500 0.009 TF:M00225_0 tf 1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 0 1 Q13093 267 1.90e-02 19 2 1 0.500 0.053 GO:0035773 BP 1 insulin secretion involved in cellular response to glucose stimulus 1 Q16849 267 1.90e-02 19 2 1 0.500 0.053 GO:0030507 MF 1 spectrin binding 1 Q16849 267 2.00e-02 20 2 1 0.500 0.050 GO:0046660 BP 1 female sex differentiation 1 Q16849 267 2.00e-02 20 2 1 0.500 0.050 GO:0042698 BP 1 ovulation cycle 1 Q16849 267 2.00e-02 20 2 1 0.500 0.050 GO:0002548 BP 1 monocyte chemotaxis 1 Q13093 267 2.00e-02 20 2 1 0.500 0.050 GO:0071827 BP 1 plasma lipoprotein particle organization 1 Q13093 267 2.20e-02 22 2 1 0.500 0.045 GO:0043679 CC 1 axon terminus 1 Q16849 267 2.20e-02 22 2 1 0.500 0.045 GO:0071825 BP 1 protein-lipid complex subunit organization 1 Q13093 267 2.30e-02 23 2 1 0.500 0.043 GO:0071674 BP 1 mononuclear cell migration 1 Q13093 267 2.72e-02 2098 2 2 1.000 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q16849,Q13093 267 2.73e-02 175 2 1 0.500 0.006 TF:M07228_0 tf 1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 0 1 Q13093 267 2.80e-02 28 2 1 0.500 0.036 GO:0044306 CC 1 neuron projection terminus 1 Q16849 267 2.81e-02 180 2 1 0.500 0.006 TF:M04143_0 tf 1 Factor: TEAD3; motif: RCATTCCNNRCATWCCN; match class: 0 1 Q13093 267 2.82e-02 181 2 1 0.500 0.006 TF:M07227_0 tf 1 Factor: SRF; motif: NNTKNCCAWATAWGGNAA; match class: 0 1 Q16849 267 2.90e-02 29 2 1 0.500 0.034 GO:0097006 BP 1 regulation of plasma lipoprotein particle levels 1 Q13093 267 2.90e-02 29 2 1 0.500 0.034 GO:0002690 BP 1 positive regulation of leukocyte chemotaxis 1 Q13093 267 2.98e-02 191 2 1 0.500 0.005 TF:M04142_0 tf 1 Factor: TEAD1; motif: RCATTCCWNRCATTCCN; match class: 0 1 Q13093 267 3.10e-02 31 2 1 0.500 0.032 GO:0071333 BP 1 cellular response to glucose stimulus 1 Q16849 267 3.30e-02 33 2 1 0.500 0.030 GO:0071326 BP 1 cellular response to monosaccharide stimulus 1 Q16849 267 3.30e-02 33 2 1 0.500 0.030 GO:0071331 BP 1 cellular response to hexose stimulus 1 Q16849 267 3.38e-02 217 2 1 0.500 0.005 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 Q16849 267 3.50e-02 35 2 1 0.500 0.029 GO:0071322 BP 1 cellular response to carbohydrate stimulus 1 Q16849 267 3.60e-02 36 2 1 0.500 0.028 GO:0002688 BP 1 regulation of leukocyte chemotaxis 1 Q13093 267 3.80e-02 244 2 1 0.500 0.004 TF:M00514_1 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 1 1 Q13093 267 3.80e-02 38 2 1 0.500 0.026 GO:0050729 BP 1 positive regulation of inflammatory response 1 Q13093 267 3.85e-02 2497 2 2 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q16849,Q13093 267 3.90e-02 39 2 1 0.500 0.026 GO:0002687 BP 1 positive regulation of leukocyte migration 1 Q13093 267 3.92e-02 252 2 1 0.500 0.004 TF:M03883_1 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 1 1 Q16849 267 3.97e-02 23 2 1 0.500 0.043 KEGG:04940 keg 1 Type I diabetes mellitus 1 Q16849 267 4.12e-02 265 2 1 0.500 0.004 TF:M01260_1 tf 1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 1 Q13093 267 4.13e-02 2588 2 2 1.000 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 Q16849,Q13093 267 4.17e-02 2601 2 2 1.000 0.001 TF:M02280_1 tf 1 Factor: AP1; motif: TGACTCA; match class: 1 1 Q16849,Q13093 267 4.20e-02 42 2 1 0.500 0.024 GO:0008406 BP 1 gonad development 1 Q16849 267 4.21e-02 238 2 1 0.500 0.004 MI:hsa-miR-32* mi 1 MI:hsa-miR-32* 1 Q13093 267 4.30e-02 43 2 1 0.500 0.023 GO:0045137 BP 1 development of primary sexual characteristics 1 Q16849 267 4.30e-02 43 2 1 0.500 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 Q16849 267 4.31e-02 277 2 1 0.500 0.004 TF:M05916_0 tf 1 Factor: ZNF407; motif: NGGTGAAARARC; match class: 0 1 Q16849 267 4.31e-02 2644 2 2 1.000 0.001 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 Q16849,Q13093 267 4.41e-02 2674 2 2 1.000 0.001 TF:M07308_0 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 0 1 Q16849,Q13093 267 4.46e-02 2689 2 2 1.000 0.001 TF:M04144_0 tf 1 Factor: TEAD3; motif: RCATTCCW; match class: 0 1 Q16849,Q13093 267 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q16849 267 4.59e-02 260 2 1 0.500 0.004 MI:mmu-miR-207 mi 1 MI:mmu-miR-207 1 Q16849 267 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q16849,Q13093 267 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 Q16849 267 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q13093 267 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q13093 267 4.95e-02 319 2 1 0.500 0.003 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q16849 267 5.00e-02 3 2 1 0.500 0.333 OMIM:147050 omi 1 IgE RESPONSIVENESS, ATOPIC; IGER;;IMMUNOGLOBULIN E, BASIC LEVEL OF, IN SERUM;;IgE, LEVEL OF; IGEL;;IgE RESPONSE UNDERLYING ALLERGIC ASTHMA AND RHINITISIgE, ELEVATED LEVEL OF, INCLUDED;;ATOPY, SUSCEPTIBILITY TO, INCLUDED;;ATOPIC HYPERSENSITIVITY, INCLUDED 1 Q13093 267 5.00e-02 59 2 1 0.500 0.017 REAC:2980736 rea 1 Peptide hormone metabolism 1 Q13093 267 5.00e-02 1 2 1 0.500 1.000 HP:0040178 hp 1 Increased level of platelet-activating factor 1 Q13093 267 5.00e-02 50 2 1 0.500 0.020 GO:0009749 BP 1 response to glucose 1 Q16849 267 5.00e-02 29 2 1 0.500 0.034 KEGG:00565 keg 1 Ether lipid metabolism 1 Q13093 267 5.00e-02 1 2 1 0.500 1.000 HP:0040177 hp 1 Abnormal level of platelet-activating factor 1 Q13093 267 5.00e-02 1 2 1 0.500 1.000 HP:0040176 hp 1 Abnormal level of phospholipids 1 Q13093 267 5.00e-02 1 2 1 0.500 1.000 HP:0040175 hp 1 Platelet-activating factor acetylhydrolase deficiency 1 Q13093 268 1.25e-06 8 2 2 1.000 0.250 GO:0099078 CC 1 BORC complex 1 P78537,Q969J3 268 2.97e-05 37 2 2 1.000 0.054 GO:0032418 BP 1 lysosome localization 1 P78537,Q969J3 268 5.91e-05 52 2 2 1.000 0.038 GO:0072384 BP 1 organelle transport along microtubule 1 P78537,Q969J3 268 1.41e-04 80 2 2 1.000 0.025 GO:0010970 BP 1 transport along microtubule 1 P78537,Q969J3 268 1.41e-04 80 2 2 1.000 0.025 GO:0099111 BP 1 microtubule-based transport 1 P78537,Q969J3 268 2.21e-04 100 2 2 1.000 0.020 GO:0030705 BP 1 cytoskeleton-dependent intracellular transport 1 P78537,Q969J3 268 6.48e-04 171 2 2 1.000 0.012 GO:0007018 BP 1 microtubule-based movement 1 P78537,Q969J3 268 8.01e-04 190 2 2 1.000 0.011 GO:0005765 CC 1 lysosomal membrane 1 P78537,Q969J3 268 8.01e-04 190 2 2 1.000 0.011 GO:0098852 CC 1 lytic vacuole membrane 1 P78537,Q969J3 268 8.79e-04 199 2 2 1.000 0.010 GO:0044445 CC 1 cytosolic part 1 P78537,Q969J3 268 1.04e-03 216 2 2 1.000 0.009 GO:0005774 CC 1 vacuolar membrane 1 P78537,Q969J3 268 1.54e-03 3 2 1 0.500 0.333 GO:0005873 CC 1 plus-end kinesin complex 1 Q969J3 268 1.54e-03 3 2 1 0.500 0.333 GO:0098574 CC 1 cytoplasmic side of lysosomal membrane 1 Q969J3 268 1.73e-03 279 2 2 1.000 0.007 GO:0044437 CC 1 vacuolar part 1 P78537,Q969J3 268 1.86e-03 289 2 2 1.000 0.007 GO:0051656 BP 1 establishment of organelle localization 1 P78537,Q969J3 268 2.06e-03 4 2 1 0.500 0.250 GO:0060155 BP 1 platelet dense granule organization 1 P78537 268 2.44e-03 331 2 2 1.000 0.006 GO:0051640 BP 1 organelle localization 1 P78537,Q969J3 268 2.60e-03 342 2 2 1.000 0.006 GO:0000323 CC 1 lytic vacuole 1 P78537,Q969J3 268 2.60e-03 342 2 2 1.000 0.006 GO:0005764 CC 1 lysosome 1 P78537,Q969J3 268 3.45e-03 394 2 2 1.000 0.005 GO:0005773 CC 1 vacuole 1 P78537,Q969J3 268 4.69e-03 459 2 2 1.000 0.004 GO:0007017 BP 1 microtubule-based process 1 P78537,Q969J3 268 4.81e-03 27 2 1 0.500 0.037 TF:M00647_0 tf 1 Factor: LXR; motif: TGGGGTYACTNGCGGTCA; match class: 0 1 P78537 268 5.55e-03 891 2 2 1.000 0.002 TF:M00210_0 tf 1 Factor: OCT-x; motif: CTNATTTGCATAY; match class: 0 1 P78537,Q969J3 268 6.44e-03 867 2 2 1.000 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 P78537,Q969J3 268 6.68e-03 13 2 1 0.500 0.077 GO:0033363 BP 1 secretory granule organization 1 P78537 268 7.33e-03 574 2 2 1.000 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 P78537,Q969J3 268 7.47e-03 42 2 1 0.500 0.024 TF:M06790_0 tf 1 Factor: ZBTB12; motif: TGGRYTAANCC; match class: 0 1 P78537 268 7.65e-03 43 2 1 0.500 0.023 TF:M06265_0 tf 1 Factor: ZNF791; motif: NAYGCRTWGATM; match class: 0 1 P78537 268 7.71e-03 15 2 1 0.500 0.067 GO:0099514 BP 1 synaptic vesicle cytoskeletal transport 1 P78537 268 7.71e-03 15 2 1 0.500 0.067 GO:0099517 BP 1 synaptic vesicle transport along microtubule 1 P78537 268 7.71e-03 15 2 1 0.500 0.067 GO:0031083 CC 1 BLOC-1 complex 1 P78537 268 7.71e-03 15 2 1 0.500 0.067 GO:0048490 BP 1 anterograde synaptic vesicle transport 1 P78537 268 1.00e-02 3 2 1 0.500 0.333 CORUM:2653 cor 1 MYC-MAX-BLOC1S1 complex 1 P78537 268 1.03e-02 20 2 1 0.500 0.050 GO:0031082 CC 1 BLOC complex 1 P78537 268 1.08e-02 21 2 1 0.500 0.048 GO:0048753 BP 1 pigment granule organization 1 P78537 268 1.08e-02 21 2 1 0.500 0.048 GO:0032438 BP 1 melanosome organization 1 P78537 268 1.08e-02 61 2 1 0.500 0.016 TF:M00766_0 tf 1 Factor: LXR; motif: TGACCGNNAGTRACCC; match class: 0 1 P78537 268 1.18e-02 23 2 1 0.500 0.043 GO:0008089 BP 1 anterograde axonal transport 1 P78537 268 1.28e-02 759 2 2 1.000 0.003 GO:0098805 CC 1 whole membrane 1 P78537,Q969J3 268 1.32e-02 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 P78537,Q969J3 268 1.39e-02 27 2 1 0.500 0.037 GO:0098930 BP 1 axonal transport 1 P78537 268 1.54e-02 30 2 1 0.500 0.033 GO:0008088 BP 1 axo-dendritic transport 1 P78537 268 1.54e-02 30 2 1 0.500 0.033 GO:0047496 BP 1 vesicle transport along microtubule 1 P78537 268 1.55e-02 87 2 1 0.500 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 P78537 268 1.60e-02 90 2 1 0.500 0.011 TF:M00423_1 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 1 P78537 268 1.74e-02 1576 2 2 1.000 0.001 TF:M00086_1 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 1 1 P78537,Q969J3 268 1.75e-02 34 2 1 0.500 0.029 GO:0099518 BP 1 vesicle cytoskeletal trafficking 1 P78537 268 1.85e-02 36 2 1 0.500 0.028 GO:0033059 BP 1 cellular pigmentation 1 P78537 268 1.86e-02 105 2 1 0.500 0.010 TF:M01211_1 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 1 1 Q969J3 268 1.90e-02 1488 2 2 1.000 0.001 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 P78537,Q969J3 268 1.99e-02 945 2 2 1.000 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 P78537,Q969J3 268 2.11e-02 119 2 1 0.500 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 Q969J3 268 2.16e-02 122 2 1 0.500 0.008 TF:M07092_0 tf 1 Factor: Fra-2; motif: NRRTGASTCAB; match class: 0 1 P78537 268 2.30e-02 1016 2 2 1.000 0.002 GO:0006928 BP 1 movement of cell or subcellular component 1 P78537,Q969J3 268 2.41e-02 136 2 1 0.500 0.007 TF:M06262_0 tf 1 Factor: ZNF415; motif: NGGGGAAWCAGA; match class: 0 1 P78537 268 2.41e-02 47 2 1 0.500 0.021 GO:0043473 BP 1 pigmentation 1 P78537 268 2.44e-02 35 2 1 0.500 0.029 REAC:432720 rea 1 Lysosome Vesicle Biogenesis 1 P78537 268 2.46e-02 48 2 1 0.500 0.021 GO:0009060 BP 1 aerobic respiration 1 P78537 268 2.48e-02 140 2 1 0.500 0.007 TF:M06084_0 tf 1 Factor: ZNF208; motif: NSGGGAAGRGGT; match class: 0 1 P78537 268 2.51e-02 1894 2 2 1.000 0.001 TF:M04385_0 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 0 1 P78537,Q969J3 268 2.51e-02 49 2 1 0.500 0.020 GO:0005758 CC 1 mitochondrial intermembrane space 1 P78537 268 2.51e-02 49 2 1 0.500 0.020 GO:0005871 CC 1 kinesin complex 1 Q969J3 268 2.66e-02 150 2 1 0.500 0.007 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 P78537 268 2.67e-02 8 2 1 0.500 0.125 CORUM:23 cor 1 BLOC-1 (biogenesis of lysosome-related organelles complex 1) 1 P78537 268 2.69e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 P78537 268 2.69e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 P78537 268 2.69e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 P78537 268 2.69e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 P78537 268 2.71e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 P78537 268 2.72e-02 53 2 1 0.500 0.019 GO:0031970 CC 1 organelle envelope lumen 1 P78537 268 2.94e-02 166 2 1 0.500 0.006 TF:M04623_1 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 1 1 P78537 268 2.94e-02 166 2 1 0.500 0.006 TF:M04505_1 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 1 1 P78537 268 2.97e-02 168 2 1 0.500 0.006 TF:M06322_0 tf 1 Factor: ZNF181; motif: NCGGAAAGACGC; match class: 0 1 P78537 268 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 P78537,Q969J3 268 3.24e-02 2153 2 2 1.000 0.001 TF:M04381_0 tf 1 Factor: ISX; motif: NYAATTAN; match class: 0 1 P78537,Q969J3 268 3.24e-02 2153 2 2 1.000 0.001 TF:M04416_0 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 0 1 P78537,Q969J3 268 3.33e-02 188 2 1 0.500 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 P78537 268 3.41e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 P78537,Q969J3 268 3.67e-02 11 2 1 0.500 0.091 CORUM:654 cor 1 BLOC1-BLOC2 complex 1 P78537 268 3.74e-02 73 2 1 0.500 0.014 GO:0097480 BP 1 establishment of synaptic vesicle localization 1 P78537 268 3.74e-02 73 2 1 0.500 0.014 GO:0048489 BP 1 synaptic vesicle transport 1 P78537 268 3.74e-02 73 2 1 0.500 0.014 GO:0099003 BP 1 vesicle-mediated transport in synapse 1 P78537 268 3.78e-02 2323 2 2 1.000 0.001 TF:M00930_0 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 0 1 P78537,Q969J3 268 3.89e-02 56 2 1 0.500 0.018 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 P78537 268 3.90e-02 76 2 1 0.500 0.013 GO:0097479 BP 1 synaptic vesicle localization 1 P78537 268 4.07e-02 2412 2 2 1.000 0.001 TF:M03561_1 tf 1 Factor: POU2F1; motif: NNATTTGCATNN; match class: 1 1 P78537,Q969J3 268 4.08e-02 2416 2 2 1.000 0.001 TF:M00965_0 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 0 1 P78537,Q969J3 268 4.18e-02 2443 2 2 1.000 0.001 TF:M07066_0 tf 1 Factor: STAT6; motif: TTCYYNGGAAN; match class: 0 1 P78537,Q969J3 268 4.20e-02 2450 2 2 1.000 0.001 TF:M00415_0 tf 1 Factor: AREB6; motif: CBGTTTSNN; match class: 0 1 P78537,Q969J3 268 4.29e-02 243 2 1 0.500 0.004 TF:M00641_0 tf 1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 0 1 Q969J3 268 4.34e-02 2489 2 2 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 P78537,Q969J3 268 4.37e-02 2500 2 2 1.000 0.001 TF:M01209_0 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 0 1 P78537,Q969J3 268 4.45e-02 252 2 1 0.500 0.004 TF:M01871_1 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 1 1 P78537 268 4.45e-02 1414 2 2 1.000 0.001 GO:0031090 CC 1 organelle membrane 1 P78537,Q969J3 268 4.54e-02 2548 2 2 1.000 0.001 TF:M00106_0 tf 1 Factor: CDP; motif: NATYGATSSS; match class: 0 1 P78537,Q969J3 268 4.59e-02 2561 2 2 1.000 0.001 TF:M04154_1 tf 1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 1 1 P78537,Q969J3 268 4.64e-02 2576 2 2 1.000 0.001 TF:M04616_0 tf 1 Factor: islet1; motif: NGNTAATG; match class: 0 1 P78537,Q969J3 268 4.69e-02 266 2 1 0.500 0.004 TF:M04196_1 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 1 1 P78537 268 4.69e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 P78537 268 4.69e-02 266 2 1 0.500 0.004 TF:M04196_0 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 0 1 P78537 268 4.95e-02 2659 2 2 1.000 0.001 TF:M04440_0 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 0 1 P78537,Q969J3 268 4.97e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 P78537,Q969J3 268 5.00e-02 72 2 1 0.500 0.014 REAC:421837 rea 1 Clathrin derived vesicle budding 1 P78537 268 5.00e-02 15 2 1 0.500 0.067 CORUM:652 cor 1 AP3-BLOC1 complex 1 P78537 268 5.00e-02 72 2 1 0.500 0.014 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 P78537 268 5.00e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 P78537,Q969J3 268 5.00e-02 2673 2 2 1.000 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 P78537,Q969J3 268 5.00e-02 2673 2 2 1.000 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 P78537,Q969J3 269 5.40e-07 2 5 2 0.400 1.000 GO:1904693 BP 1 midbrain morphogenesis 1 Q9NPG1,O60353 269 1.92e-05 95 5 3 0.600 0.032 GO:0001738 BP 1 morphogenesis of a polarized epithelium 1 Q9NPG1,O60353,Q8N205 269 3.56e-05 12 5 2 0.400 0.167 GO:0048854 BP 1 brain morphogenesis 1 Q9NPG1,O60353 269 5.66e-05 15 5 2 0.400 0.133 GO:0042813 MF 1 Wnt-activated receptor activity 1 Q9NPG1,O60353 269 8.24e-05 18 5 2 0.400 0.111 GO:0017147 MF 1 Wnt-protein binding 1 Q9NPG1,O60353 269 2.34e-04 30 5 2 0.400 0.067 GO:0007223 BP 1 Wnt signaling pathway, calcium modulating pathway 1 Q9NPG1,O60353 269 2.42e-04 221 5 3 0.600 0.014 GO:0002009 BP 1 morphogenesis of an epithelium 1 Q9NPG1,O60353,Q8N205 269 4.35e-04 269 5 3 0.600 0.011 GO:0048729 BP 1 tissue morphogenesis 1 Q9NPG1,O60353,Q8N205 269 6.83e-04 51 5 2 0.400 0.039 GO:0030901 BP 1 midbrain development 1 Q9NPG1,O60353 269 7.10e-04 37 5 2 0.400 0.054 KEGG:05217 keg 1 Basal cell carcinoma 1 Q9NPG1,O60353 269 1.01e-03 45 5 2 0.400 0.044 REAC:373080 rea 1 Class B/2 (Secretin family receptors) 1 Q9NPG1,O60353 269 1.30e-03 51 5 2 0.400 0.039 REAC:4086398 rea 1 Ca2+ pathway 1 Q9NPG1,O60353 269 1.40e-03 153 5 2 0.400 0.013 TF:M05731_0 tf 1 Factor: ZNF660; motif: NGGGGGGAACSM; match class: 0 1 Q9NPG1,O60353 269 1.56e-03 1 5 1 0.200 1.000 GO:0031309 CC 1 integral component of nuclear outer membrane 1 Q8N205 269 1.56e-03 1 5 1 0.200 1.000 GO:1990608 BP 1 mitotic spindle pole body localization to nuclear envelope 1 Q8N205 269 1.56e-03 1 5 1 0.200 1.000 GO:0031308 CC 1 intrinsic component of nuclear outer membrane 1 Q8N205 269 1.56e-03 1 5 1 0.200 1.000 GO:1903087 BP 1 mitotic spindle pole body duplication 1 Q8N205 269 1.84e-03 1818 5 4 0.800 0.002 TF:M00412_1 tf 1 Factor: AREB6; motif: NNYNYACCTGWVT; match class: 1 1 Q6P597,O95159,O60353,Q8N205 269 1.86e-03 439 5 3 0.600 0.007 GO:0060429 BP 1 epithelium development 1 Q9NPG1,O60353,Q8N205 269 1.90e-03 85 5 2 0.400 0.024 GO:0090175 BP 1 regulation of establishment of planar polarity 1 Q9NPG1,O60353 269 1.90e-03 85 5 2 0.400 0.024 GO:0060071 BP 1 Wnt signaling pathway, planar cell polarity pathway 1 Q9NPG1,O60353 269 2.04e-03 88 5 2 0.400 0.023 GO:0007164 BP 1 establishment of tissue polarity 1 Q9NPG1,O60353 269 2.04e-03 88 5 2 0.400 0.023 GO:0001736 BP 1 establishment of planar polarity 1 Q9NPG1,O60353 269 3.07e-03 77 5 2 0.400 0.026 KEGG:04916 keg 1 Melanogenesis 1 Q9NPG1,O60353 269 3.11e-03 2 5 1 0.200 0.500 GO:0030474 BP 1 spindle pole body duplication 1 Q8N205 269 3.11e-03 2 5 1 0.200 0.500 GO:0071789 BP 1 spindle pole body localization to nuclear envelope 1 Q8N205 269 3.11e-03 2 5 1 0.200 0.500 GO:0070632 BP 1 establishment of spindle pole body localization 1 Q8N205 269 3.11e-03 2 5 1 0.200 0.500 GO:0070631 BP 1 spindle pole body localization 1 Q8N205 269 3.11e-03 2 5 1 0.200 0.500 GO:0045976 BP 1 negative regulation of mitotic cell cycle, embryonic 1 Q9NPG1 269 3.11e-03 2 5 1 0.200 0.500 GO:0051300 BP 1 spindle pole body organization 1 Q8N205 269 3.11e-03 2 5 1 0.200 0.500 GO:0071790 BP 1 establishment of spindle pole body localization to nuclear envelope 1 Q8N205 269 3.12e-03 109 5 2 0.400 0.018 GO:1905330 BP 1 regulation of morphogenesis of an epithelium 1 Q9NPG1,O60353 269 3.52e-03 84 5 2 0.400 0.024 REAC:4086400 rea 1 PCP/CE pathway 1 Q9NPG1,O60353 269 3.97e-03 123 5 2 0.400 0.016 GO:0035567 BP 1 non-canonical Wnt signaling pathway 1 Q9NPG1,O60353 269 4.03e-03 124 5 2 0.400 0.016 GO:2000027 BP 1 regulation of organ morphogenesis 1 Q9NPG1,O60353 269 4.31e-03 11 5 1 0.200 0.091 TF:M05701_0 tf 1 Factor: ZNF30; motif: KGTGGKACCMGM; match class: 0 1 O60353 269 4.65e-03 281 5 2 0.400 0.007 TF:M03855_0 tf 1 Factor: Tbx5:csx; motif: YMTYCTSWCACYTGN; match class: 0 1 Q6P597,Q8N205 269 4.67e-03 3 5 1 0.200 0.333 GO:0044732 CC 1 mitotic spindle pole body 1 Q8N205 269 4.67e-03 3 5 1 0.200 0.333 GO:0009794 BP 1 regulation of mitotic cell cycle, embryonic 1 Q9NPG1 269 4.67e-03 3 5 1 0.200 0.333 GO:0045448 BP 1 mitotic cell cycle, embryonic 1 Q9NPG1 269 5.01e-03 292 5 2 0.400 0.007 TF:M04106_0 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 0 1 Q6P597,O95159 269 5.57e-03 146 5 2 0.400 0.014 GO:0004930 MF 1 G-protein coupled receptor activity 1 Q9NPG1,O60353 269 5.99e-03 108 5 2 0.400 0.019 KEGG:04550 keg 1 Signaling pathways regulating pluripotency of stem cells 1 Q9NPG1,O60353 269 6.43e-03 112 5 2 0.400 0.018 KEGG:05224 keg 1 Breast cancer 1 Q9NPG1,O60353 269 6.66e-03 17 5 1 0.200 0.059 TF:M06362_0 tf 1 Factor: ZNF730; motif: KGGGACWAAAGM; match class: 0 1 Q8N205 269 7.25e-03 119 5 2 0.400 0.017 KEGG:04310 keg 1 Wnt signaling pathway 1 Q9NPG1,O60353 269 7.51e-03 2622 5 4 0.800 0.002 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 Q9NPG1,Q6P597,O95159,Q8N205 269 7.78e-03 5 5 1 0.200 0.200 GO:0045198 BP 1 establishment of epithelial cell apical/basal polarity 1 Q8N205 269 8.23e-03 129 5 2 0.400 0.016 REAC:3858494 rea 1 Beta-catenin independent WNT signaling 1 Q9NPG1,O60353 269 8.36e-03 128 5 2 0.400 0.016 KEGG:04390 keg 1 Hippo signaling pathway 1 Q9NPG1,O60353 269 8.94e-03 751 5 3 0.600 0.004 GO:0009888 BP 1 tissue development 1 Q9NPG1,O60353,Q8N205 269 9.00e-03 23 5 1 0.200 0.043 TF:M05536_0 tf 1 Factor: ZNF777; motif: NGGGMCKGCAGA; match class: 0 1 Q8N205 269 9.14e-03 134 5 2 0.400 0.015 KEGG:04150 keg 1 mTOR signaling pathway 1 Q9NPG1,O60353 269 9.32e-03 5 5 1 0.200 0.200 REAC:5340588 rea 1 RNF mutants show enhanced WNT signaling and proliferation 1 O60353 269 9.33e-03 6 5 1 0.200 0.167 GO:0005640 CC 1 nuclear outer membrane 1 Q8N205 269 9.33e-03 6 5 1 0.200 0.167 GO:0034993 CC 1 LINC complex 1 Q8N205 269 9.33e-03 6 5 1 0.200 0.167 GO:0030859 BP 1 polarized epithelial cell differentiation 1 Q8N205 269 9.33e-03 6 5 1 0.200 0.167 GO:0034992 CC 1 microtubule organizing center attachment site 1 Q8N205 269 9.48e-03 191 5 2 0.400 0.010 GO:0060070 BP 1 canonical Wnt signaling pathway 1 Q9NPG1,O60353 269 9.67e-03 140 5 2 0.400 0.014 REAC:500792 rea 1 GPCR ligand binding 1 Q9NPG1,O60353 269 9.81e-03 2813 5 4 0.800 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353 269 1.09e-02 7 5 1 0.200 0.143 GO:0035089 BP 1 establishment of apical/basal cell polarity 1 Q8N205 269 1.09e-02 7 5 1 0.200 0.143 GO:0061549 BP 1 sympathetic ganglion development 1 Q9NPG1 269 1.09e-02 7 5 1 0.200 0.143 GO:1900118 BP 1 negative regulation of execution phase of apoptosis 1 Q9NPG1 269 1.09e-02 7 5 1 0.200 0.143 GO:0002052 BP 1 positive regulation of neuroblast proliferation 1 Q9NPG1 269 1.10e-02 28 5 1 0.200 0.036 TF:M05440_0 tf 1 Factor: Nkx2-3; motif: TAAAGAYGATNNNNNNNRT; match class: 0 1 Q6P597 269 1.14e-02 210 5 2 0.400 0.010 GO:0007420 BP 1 brain development 1 Q9NPG1,O60353 269 1.16e-02 1418 5 3 0.600 0.002 TF:M07434_0 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 0 1 Q9NPG1,O60353,Q8N205 269 1.24e-02 219 5 2 0.400 0.009 GO:0060322 BP 1 head development 1 Q9NPG1,O60353 269 1.24e-02 8 5 1 0.200 0.125 GO:0061162 BP 1 establishment of monopolar cell polarity 1 Q8N205 269 1.24e-02 8 5 1 0.200 0.125 GO:0061548 BP 1 ganglion development 1 Q9NPG1 269 1.24e-02 8 5 1 0.200 0.125 GO:0005816 CC 1 spindle pole body 1 Q8N205 269 1.24e-02 8 5 1 0.200 0.125 GO:0044453 CC 1 nuclear membrane part 1 Q8N205 269 1.25e-02 411 5 2 0.400 0.005 MI:hsa-miR-92a mi 1 MI:hsa-miR-92a 1 O60353,Q8N205 269 1.27e-02 415 5 2 0.400 0.005 MI:hsa-miR-92b mi 1 MI:hsa-miR-92b 1 O60353,Q8N205 269 1.31e-02 422 5 2 0.400 0.005 MI:hsa-miR-885-5p mi 1 MI:hsa-miR-885-5p 1 O95159,Q8N205 269 1.33e-02 34 5 1 0.200 0.029 TF:M05768_0 tf 1 Factor: ZNF544; motif: GTWAAAACGM; match class: 0 1 Q9NPG1 269 1.34e-02 427 5 2 0.400 0.005 MI:mmu-miR-697 mi 1 MI:mmu-miR-697 1 O95159,Q8N205 269 1.37e-02 490 5 2 0.400 0.004 TF:M02270_1 tf 1 Factor: FOXO3; motif: KGTAAACA; match class: 1 1 Q9NPG1,O60353 269 1.40e-02 9 5 1 0.200 0.111 GO:0061339 BP 1 establishment or maintenance of monopolar cell polarity 1 Q8N205 269 1.40e-02 9 5 1 0.200 0.111 GO:1902692 BP 1 regulation of neuroblast proliferation 1 Q9NPG1 269 1.42e-02 3101 5 4 0.800 0.001 TF:M03810_0 tf 1 Factor: RXR:PXR; motif: NNNTGAMCTYNNNTGAMCYN; match class: 0 1 Q9NPG1,Q6P597,O95159,Q8N205 269 1.49e-02 512 5 2 0.400 0.004 TF:M00192_1 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 1 1 Q9NPG1,O95159 269 1.50e-02 1554 5 3 0.600 0.002 TF:M04012_0 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 0 1 Q9NPG1,O95159,O60353 269 1.50e-02 173 5 2 0.400 0.012 KEGG:05205 keg 1 Proteoglycans in cancer 1 Q9NPG1,O60353 269 1.55e-02 10 5 1 0.200 0.100 GO:2000648 BP 1 positive regulation of stem cell proliferation 1 Q9NPG1 269 1.57e-02 5544 5 5 1.000 0.001 TF:M00983_0 tf 1 Factor: MAF; motif: NGCTGAGTCAN; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 1.64e-02 474 5 2 0.400 0.004 MI:hsa-miR-142-5p mi 1 MI:hsa-miR-142-5p 1 O95159,Q8N205 269 1.67e-02 478 5 2 0.400 0.004 MI:hsa-miR-486-3p mi 1 MI:hsa-miR-486-3p 1 O95159,Q8N205 269 1.71e-02 11 5 1 0.200 0.091 GO:0048485 BP 1 sympathetic nervous system development 1 Q9NPG1 269 1.71e-02 551 5 2 0.400 0.004 TF:M00776_0 tf 1 Factor: SREBP; motif: VNNVTCACCCYA; match class: 0 1 O95159,Q8N205 269 1.83e-02 47 5 1 0.200 0.021 TF:M06752_0 tf 1 Factor: ZN337; motif: KGGGTAGGAAGA; match class: 0 1 O95159 269 1.85e-02 10 5 1 0.200 0.100 HP:0001806 hp 1 Onycholysis 1 O60353 269 1.86e-02 12 5 1 0.200 0.083 GO:0090162 BP 1 establishment of epithelial cell polarity 1 Q8N205 269 1.86e-02 12 5 1 0.200 0.083 GO:0045992 BP 1 negative regulation of embryonic development 1 Q9NPG1 269 1.87e-02 48 5 1 0.200 0.021 TF:M06308_1 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 1 1 O60353 269 1.98e-02 594 5 2 0.400 0.003 TF:M00935_1 tf 1 Factor: NF-AT; motif: NWGGAAANWN; match class: 1 1 O60353,Q8N205 269 2.02e-02 13 5 1 0.200 0.077 GO:2000179 BP 1 positive regulation of neural precursor cell proliferation 1 Q9NPG1 269 2.05e-02 11 5 1 0.200 0.091 REAC:5625970 rea 1 RHO GTPases activate KTN1 1 Q6P597 269 2.05e-02 1737 5 3 0.600 0.002 TF:M00350_1 tf 1 Factor: GATA-3; motif: NGAGATAANA; match class: 1 1 Q9NPG1,Q6P597,O60353 269 2.10e-02 54 5 1 0.200 0.019 TF:M01023_0 tf 1 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 0 1 Q8N205 269 2.14e-02 544 5 2 0.400 0.004 MI:hsa-miR-590-5p mi 1 MI:hsa-miR-590-5p 1 O60353,Q8N205 269 2.14e-02 55 5 1 0.200 0.018 TF:M00769_1 tf 1 Factor: AML; motif: NNGKNTGTGGTTWNC; match class: 1 1 Q8N205 269 2.14e-02 55 5 1 0.200 0.018 TF:M03913_1 tf 1 Factor: KLF14; motif: NRCCACGCCCMCYN; match class: 1 1 Q6P597 269 2.17e-02 5915 5 5 1.000 0.001 TF:M03572_0 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 2.31e-02 301 5 2 0.400 0.007 GO:0016055 BP 1 Wnt signaling pathway 1 Q9NPG1,O60353 269 2.31e-02 301 5 2 0.400 0.007 GO:0198738 BP 1 cell-cell signaling by wnt 1 Q9NPG1,O60353 269 2.33e-02 15 5 1 0.200 0.067 GO:0048483 BP 1 autonomic nervous system development 1 Q9NPG1 269 2.35e-02 218 5 2 0.400 0.009 KEGG:05166 keg 1 HTLV-I infection 1 Q9NPG1,O60353 269 2.40e-02 307 5 2 0.400 0.007 GO:0007417 BP 1 central nervous system development 1 Q9NPG1,O60353 269 2.61e-02 4019 5 5 1.000 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 2.65e-02 323 5 2 0.400 0.006 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 Q9NPG1,O60353 269 2.68e-02 69 5 1 0.200 0.014 TF:M06709_0 tf 1 Factor: ZNF355P; motif: GWTAAAAMGC; match class: 0 1 Q9NPG1 269 2.69e-02 1025 5 3 0.600 0.003 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q9NPG1,O60353,Q8N205 269 2.72e-02 3694 5 4 0.800 0.001 TF:M03868_1 tf 1 Factor: CP2; motif: NTGNCTGGNN; match class: 1 1 Q6P597,O95159,O60353,Q8N205 269 2.73e-02 1107 5 3 0.600 0.003 GO:0009653 BP 1 anatomical structure morphogenesis 1 Q9NPG1,O60353,Q8N205 269 2.78e-02 6218 5 5 1.000 0.001 TF:M03557_0 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 2.79e-02 15 5 1 0.200 0.067 REAC:4641263 rea 1 Regulation of FZD by ubiquitination 1 O60353 269 2.79e-02 18 5 1 0.200 0.056 GO:0072091 BP 1 regulation of stem cell proliferation 1 Q9NPG1 269 2.79e-02 18 5 1 0.200 0.056 GO:1900117 BP 1 regulation of execution phase of apoptosis 1 Q9NPG1 269 2.93e-02 247 5 2 0.400 0.008 REAC:195721 rea 1 Signaling by Wnt 1 Q9NPG1,O60353 269 2.95e-02 76 5 1 0.200 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q8N205 269 3.07e-02 348 5 2 0.400 0.006 GO:0009887 BP 1 animal organ morphogenesis 1 Q9NPG1,O60353 269 3.10e-02 20 5 1 0.200 0.050 GO:0045197 BP 1 establishment or maintenance of epithelial cell apical/basal polarity 1 Q8N205 269 3.11e-02 6358 5 5 1.000 0.001 TF:M02099_0 tf 1 Factor: MITF; motif: CATGTGM; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 3.23e-02 2050 5 3 0.600 0.001 TF:M00216_1 tf 1 Factor: TATA; motif: NCTATAAAAR; match class: 1 1 Q9NPG1,O95159,O60353 269 3.37e-02 87 5 1 0.200 0.011 TF:M01724_0 tf 1 Factor: T3RALPHA; motif: NNTSRGGTCAN; match class: 0 1 Q6P597 269 3.41e-02 22 5 1 0.200 0.045 GO:0007405 BP 1 neuroblast proliferation 1 Q9NPG1 269 3.41e-02 22 5 1 0.200 0.045 GO:2000177 BP 1 regulation of neural precursor cell proliferation 1 Q9NPG1 269 3.57e-02 23 5 1 0.200 0.043 GO:0061245 BP 1 establishment or maintenance of bipolar cell polarity 1 Q8N205 269 3.57e-02 23 5 1 0.200 0.043 GO:0035088 BP 1 establishment or maintenance of apical/basal cell polarity 1 Q8N205 269 3.63e-02 4293 5 5 1.000 0.001 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 3.65e-02 4298 5 5 1.000 0.001 HPA:009010_02 hpa 1 colon; endothelial cells[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 3.96e-02 1175 5 3 0.600 0.003 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q9NPG1,O60353,Q8N205 269 4.13e-02 4407 5 5 1.000 0.001 HPA:035030_02 hpa 1 skin 1; keratinocytes[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 4.54e-02 4491 5 5 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 4.58e-02 2331 5 3 0.600 0.001 TF:M01223_0 tf 1 Factor: P50:P50; motif: NRGGGAMTNCCCN; match class: 0 1 Q6P597,O95159,O60353 269 4.61e-02 2337 5 3 0.600 0.001 TF:M04414_0 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 0 1 Q9NPG1,Q6P597,O95159 269 4.73e-02 944 5 2 0.400 0.002 TF:M01657_0 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 0 1 O95159,Q8N205 269 4.79e-02 4310 5 4 0.800 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 Q9NPG1,O95159,O60353,Q8N205 269 4.86e-02 1263 5 3 0.600 0.002 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 Q9NPG1,O60353,Q8N205 269 4.88e-02 6958 5 5 1.000 0.001 TF:M00076_0 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 0 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 4.99e-02 972 5 2 0.400 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q9NPG1,O60353 269 5.00e-02 325 5 2 0.400 0.006 KEGG:05200 keg 1 Pathways in cancer 1 Q9NPG1,O60353 269 5.00e-02 1 5 1 0.200 1.000 OMIM:615540 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 76; DFNB76 1 Q8N205 269 5.00e-02 1 5 1 0.200 1.000 OMIM:614157 omi 1 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10; NDNC10;;CLAW-SHAPED NAILS;;ONYCHAUXIS, HYPONYCHIA, AND ONYCHOLYSIS 1 O60353 269 5.00e-02 4578 5 5 1.000 0.001 HPA:003010_02 hpa 1 bone marrow; hematopoietic cells[Uncertain,Medium] 1 Q9NPG1,Q6P597,O95159,O60353,Q8N205 269 5.00e-02 448 5 2 0.400 0.004 GO:0004888 MF 1 transmembrane signaling receptor activity 1 Q9NPG1,O60353 269 5.00e-02 27 5 1 0.200 0.037 REAC:4791275 rea 1 Signaling by WNT in cancer 1 O60353 270 1.28e-03 1 2 1 0.500 1.000 GO:0071393 BP 1 cellular response to progesterone stimulus 1 P12931 270 2.57e-03 2 2 1 0.500 0.500 GO:0033625 BP 1 positive regulation of integrin activation 1 P12931 270 2.57e-03 2 2 1 0.500 0.500 GO:0086098 BP 1 angiotensin-activated signaling pathway involved in heart process 1 P12931 270 2.84e-03 3 2 1 0.500 0.333 REAC:191647 rea 1 c-src mediated regulation of Cx43 function and closure of gap junctions 1 P12931 270 2.84e-03 3 2 1 0.500 0.333 REAC:191650 rea 1 Regulation of gap junction activity 1 P12931 270 3.85e-03 3 2 1 0.500 0.333 GO:1904180 BP 1 negative regulation of membrane depolarization 1 P12931 270 3.85e-03 3 2 1 0.500 0.333 GO:0051902 BP 1 negative regulation of mitochondrial depolarization 1 P12931 270 5.14e-03 4 2 1 0.500 0.250 GO:0050847 BP 1 progesterone receptor signaling pathway 1 P12931 270 5.14e-03 4 2 1 0.500 0.250 GO:2001286 BP 1 regulation of caveolin-mediated endocytosis 1 P12931 270 5.88e-03 13 2 1 0.500 0.077 TF:M05968_0 tf 1 Factor: ZNF316; motif: KGGTCCGGSGGM; match class: 0 1 Q7L9B9 270 6.42e-03 5 2 1 0.500 0.200 GO:0032463 BP 1 negative regulation of protein homooligomerization 1 P12931 270 6.42e-03 5 2 1 0.500 0.200 GO:0033623 BP 1 regulation of integrin activation 1 P12931 270 6.62e-03 7 2 1 0.500 0.143 REAC:430116 rea 1 GP1b-IX-V activation signalling 1 P12931 270 7.70e-03 6 2 1 0.500 0.167 GO:0036035 BP 1 osteoclast development 1 P12931 270 7.70e-03 6 2 1 0.500 0.167 GO:0086103 BP 1 G-protein coupled receptor signaling pathway involved in heart process 1 P12931 270 8.52e-03 9 2 1 0.500 0.111 REAC:418886 rea 1 Netrin mediated repulsion signals 1 P12931 270 8.99e-03 7 2 1 0.500 0.143 GO:2000394 BP 1 positive regulation of lamellipodium morphogenesis 1 P12931 270 8.99e-03 7 2 1 0.500 0.143 GO:0032460 BP 1 negative regulation of protein oligomerization 1 P12931 270 8.99e-03 7 2 1 0.500 0.143 GO:0007172 BP 1 signal complex assembly 1 P12931 270 8.99e-03 7 2 1 0.500 0.143 GO:0051900 BP 1 regulation of mitochondrial depolarization 1 P12931 270 8.99e-03 7 2 1 0.500 0.143 GO:0038166 BP 1 angiotensin-activated signaling pathway 1 P12931 270 9.11e-03 2 2 1 0.500 0.500 CORUM:2073 cor 1 TNFRSF11A-TRAF6-SRC complex 1 P12931 270 9.11e-03 2 2 1 0.500 0.500 CORUM:2471 cor 1 SRC-PRKCD-CDCP1 complex 1 P12931 270 9.46e-03 10 2 1 0.500 0.100 REAC:391160 rea 1 Signal regulatory protein (SIRP) family interactions 1 P12931 270 9.94e-03 22 2 1 0.500 0.045 TF:M06256_0 tf 1 Factor: ZNF177; motif: NCYGGCGGRYCC; match class: 0 1 Q7L9B9 270 1.03e-02 8 2 1 0.500 0.125 GO:0098751 BP 1 bone cell development 1 P12931 270 1.03e-02 8 2 1 0.500 0.125 GO:1990776 BP 1 response to angiotensin 1 P12931 270 1.03e-02 8 2 1 0.500 0.125 GO:1904385 BP 1 cellular response to angiotensin 1 P12931 270 1.03e-02 8 2 1 0.500 0.125 GO:0033622 BP 1 integrin activation 1 P12931 270 1.03e-02 8 2 1 0.500 0.125 GO:0072584 BP 1 caveolin-mediated endocytosis 1 P12931 270 1.04e-02 11 2 1 0.500 0.091 REAC:210990 rea 1 PECAM1 interactions 1 P12931 270 1.04e-02 11 2 1 0.500 0.091 REAC:2029481 rea 1 FCGR activation 1 P12931 270 1.16e-02 9 2 1 0.500 0.111 GO:0071801 BP 1 regulation of podosome assembly 1 P12931 270 1.16e-02 9 2 1 0.500 0.111 GO:2000392 BP 1 regulation of lamellipodium morphogenesis 1 P12931 270 1.16e-02 9 2 1 0.500 0.111 GO:0051882 BP 1 mitochondrial depolarization 1 P12931 270 1.20e-02 821 2 2 1.000 0.002 TF:M00146_1 tf 1 Factor: HSF1; motif: AGAANRTTCN; match class: 1 1 Q7L9B9,P12931 270 1.23e-02 13 2 1 0.500 0.077 REAC:171007 rea 1 p38MAPK events 1 P12931 270 1.23e-02 13 2 1 0.500 0.077 REAC:1433559 rea 1 Regulation of KIT signaling 1 P12931 270 1.28e-02 10 2 1 0.500 0.100 GO:0045124 BP 1 regulation of bone resorption 1 P12931 270 1.28e-02 10 2 1 0.500 0.100 GO:0032462 BP 1 regulation of protein homooligomerization 1 P12931 270 1.32e-02 14 2 1 0.500 0.071 REAC:418885 rea 1 DCC mediated attractive signaling 1 P12931 270 1.37e-02 3 2 1 0.500 0.333 CORUM:5928 cor 1 CNK1-SRC-RAF1 complex 1 P12931 270 1.37e-02 3 2 1 0.500 0.333 CORUM:2470 cor 1 p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex 1 P12931 270 1.37e-02 3 2 1 0.500 0.333 CORUM:5282 cor 1 CAS-SRC-FAK complex 1 P12931 270 1.37e-02 3 2 1 0.500 0.333 CORUM:5713 cor 1 SH3P2/OSTF1-CBL-SRC complex 1 P12931 270 1.41e-02 11 2 1 0.500 0.091 GO:0032570 BP 1 response to progesterone 1 P12931 270 1.41e-02 11 2 1 0.500 0.091 GO:0072673 BP 1 lamellipodium morphogenesis 1 P12931 270 1.41e-02 11 2 1 0.500 0.091 GO:0032211 BP 1 negative regulation of telomere maintenance via telomerase 1 P12931 270 1.41e-02 11 2 1 0.500 0.091 GO:0051974 BP 1 negative regulation of telomerase activity 1 P12931 270 1.42e-02 15 2 1 0.500 0.067 REAC:354194 rea 1 GRB2:SOS provides linkage to MAPK signaling for Integrins 1 P12931 270 1.42e-02 15 2 1 0.500 0.067 REAC:1295596 rea 1 Spry regulation of FGF signaling 1 P12931 270 1.42e-02 15 2 1 0.500 0.067 REAC:372708 rea 1 p130Cas linkage to MAPK signaling for integrins 1 P12931 270 1.47e-02 911 2 2 1.000 0.002 TF:M01037_0 tf 1 Factor: GLI; motif: NBTGGGTGGTCN; match class: 0 1 Q7L9B9,P12931 270 1.51e-02 16 2 1 0.500 0.062 REAC:157858 rea 1 Gap junction trafficking and regulation 1 P12931 270 1.54e-02 12 2 1 0.500 0.083 GO:0061515 BP 1 myeloid cell development 1 P12931 270 1.54e-02 12 2 1 0.500 0.083 GO:0046875 MF 1 ephrin receptor binding 1 P12931 270 1.61e-02 17 2 1 0.500 0.059 REAC:3928664 rea 1 Ephrin signaling 1 P12931 270 1.67e-02 13 2 1 0.500 0.077 GO:2000811 BP 1 negative regulation of anoikis 1 P12931 270 1.67e-02 13 2 1 0.500 0.077 GO:0051895 BP 1 negative regulation of focal adhesion assembly 1 P12931 270 1.67e-02 13 2 1 0.500 0.077 GO:0045453 BP 1 bone resorption 1 P12931 270 1.67e-02 13 2 1 0.500 0.077 GO:0043114 BP 1 regulation of vascular permeability 1 P12931 270 1.67e-02 13 2 1 0.500 0.077 GO:0046850 BP 1 regulation of bone remodeling 1 P12931 270 1.76e-02 39 2 1 0.500 0.026 TF:M05876_1 tf 1 Factor: ZNF526; motif: KGGGTGGGGWRC; match class: 1 1 P12931 270 1.80e-02 19 2 1 0.500 0.053 REAC:389513 rea 1 CTLA4 inhibitory signaling 1 P12931 270 1.80e-02 14 2 1 0.500 0.071 GO:0071800 BP 1 podosome assembly 1 P12931 270 1.80e-02 14 2 1 0.500 0.071 GO:1903392 BP 1 negative regulation of adherens junction organization 1 P12931 270 1.80e-02 14 2 1 0.500 0.071 GO:1904357 BP 1 negative regulation of telomere maintenance via telomere lengthening 1 P12931 270 1.81e-02 40 2 1 0.500 0.025 TF:M00068_1 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 1 1 Q7L9B9 270 1.82e-02 4 2 1 0.500 0.250 CORUM:2377 cor 1 ITGA2b-ITGB3-CD47-SRC complex 1 P12931 270 1.89e-02 20 2 1 0.500 0.050 REAC:5654732 rea 1 Negative regulation of FGFR3 signaling 1 P12931 270 1.89e-02 20 2 1 0.500 0.050 REAC:418592 rea 1 ADP signalling through P2Y purinoceptor 1 1 P12931 270 1.99e-02 21 2 1 0.500 0.048 REAC:5654733 rea 1 Negative regulation of FGFR4 signaling 1 P12931 270 2.18e-02 17 2 1 0.500 0.059 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 P12931 270 2.18e-02 17 2 1 0.500 0.059 GO:2000641 BP 1 regulation of early endosome to late endosome transport 1 P12931 270 2.18e-02 17 2 1 0.500 0.059 GO:0042169 MF 1 SH2 domain binding 1 P12931 270 2.18e-02 17 2 1 0.500 0.059 GO:1901889 BP 1 negative regulation of cell junction assembly 1 P12931 270 2.27e-02 24 2 1 0.500 0.042 REAC:5654727 rea 1 Negative regulation of FGFR2 signaling 1 P12931 270 2.27e-02 24 2 1 0.500 0.042 REAC:5654726 rea 1 Negative regulation of FGFR1 signaling 1 P12931 270 2.31e-02 18 2 1 0.500 0.056 GO:2000209 BP 1 regulation of anoikis 1 P12931 270 2.36e-02 25 2 1 0.500 0.040 REAC:354192 rea 1 Integrin alphaIIb beta3 signaling 1 P12931 270 2.36e-02 25 2 1 0.500 0.040 REAC:5673000 rea 1 RAF activation 1 P12931 270 2.36e-02 25 2 1 0.500 0.040 REAC:456926 rea 1 Thrombin signalling through proteinase activated receptors (PARs) 1 P12931 270 2.44e-02 19 2 1 0.500 0.053 GO:0003254 BP 1 regulation of membrane depolarization 1 P12931 270 2.44e-02 19 2 1 0.500 0.053 GO:1901655 BP 1 cellular response to ketone 1 P12931 270 2.47e-02 36 2 1 0.500 0.028 KEGG:05219 keg 1 Bladder cancer 1 P12931 270 2.55e-02 27 2 1 0.500 0.037 REAC:392518 rea 1 Signal amplification 1 P12931 270 2.57e-02 20 2 1 0.500 0.050 GO:0046849 BP 1 bone remodeling 1 P12931 270 2.57e-02 20 2 1 0.500 0.050 GO:0001953 BP 1 negative regulation of cell-matrix adhesion 1 P12931 270 2.57e-02 20 2 1 0.500 0.050 GO:0043276 BP 1 anoikis 1 P12931 270 2.57e-02 20 2 1 0.500 0.050 GO:1903649 BP 1 regulation of cytoplasmic transport 1 P12931 270 2.65e-02 28 2 1 0.500 0.036 REAC:437239 rea 1 Recycling pathway of L1 1 P12931 270 2.65e-02 28 2 1 0.500 0.036 REAC:389356 rea 1 CD28 co-stimulation 1 P12931 270 2.65e-02 28 2 1 0.500 0.036 REAC:3928663 rea 1 EPHA-mediated growth cone collapse 1 P12931 270 2.69e-02 21 2 1 0.500 0.048 GO:0034103 BP 1 regulation of tissue remodeling 1 P12931 270 2.74e-02 29 2 1 0.500 0.034 REAC:76009 rea 1 Platelet Aggregation (Plug Formation) 1 P12931 270 2.82e-02 22 2 1 0.500 0.045 GO:0032459 BP 1 regulation of protein oligomerization 1 P12931 270 2.82e-02 22 2 1 0.500 0.045 GO:2000279 BP 1 negative regulation of DNA biosynthetic process 1 P12931 270 2.89e-02 64 2 1 0.500 0.016 TF:M05995_0 tf 1 Factor: ZNF180; motif: NGRGGGGGCAGC; match class: 0 1 Q7L9B9 270 2.95e-02 23 2 1 0.500 0.043 GO:0051057 BP 1 positive regulation of small GTPase mediated signal transduction 1 P12931 270 2.98e-02 66 2 1 0.500 0.015 TF:M06117_1 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 1 1 P12931 270 3.08e-02 24 2 1 0.500 0.042 GO:0032205 BP 1 negative regulation of telomere maintenance 1 P12931 270 3.18e-02 7 2 1 0.500 0.143 CORUM:3137 cor 1 MASH1 promoter-coactivator complex 1 P12931 270 3.21e-02 25 2 1 0.500 0.040 GO:0048008 BP 1 platelet-derived growth factor receptor signaling pathway 1 P12931 270 3.25e-02 72 2 1 0.500 0.014 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 Q7L9B9 270 3.25e-02 72 2 1 0.500 0.014 TF:M07343_1 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 1 1 P12931 270 3.46e-02 27 2 1 0.500 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 P12931 270 3.46e-02 27 2 1 0.500 0.037 GO:0097110 MF 1 scaffold protein binding 1 P12931 270 3.49e-02 37 2 1 0.500 0.027 REAC:5674135 rea 1 MAP2K and MAPK activation 1 P12931 270 3.59e-02 38 2 1 0.500 0.026 REAC:373752 rea 1 Netrin-1 signaling 1 P12931 270 3.59e-02 28 2 1 0.500 0.036 GO:0030316 BP 1 osteoclast differentiation 1 P12931 270 3.64e-02 8 2 1 0.500 0.125 CORUM:3142 cor 1 CAMK2-delta-MASH1 promoter-coactivator complex 1 P12931 270 3.68e-02 39 2 1 0.500 0.026 REAC:3928662 rea 1 EPHB-mediated forward signaling 1 P12931 270 3.68e-02 39 2 1 0.500 0.026 REAC:3928665 rea 1 EPH-ephrin mediated repulsion of cells 1 P12931 270 3.71e-02 54 2 1 0.500 0.019 KEGG:04370 keg 1 VEGF signaling pathway 1 P12931 270 3.72e-02 29 2 1 0.500 0.034 GO:0051881 BP 1 regulation of mitochondrial membrane potential 1 P12931 270 3.75e-02 1453 2 2 1.000 0.001 TF:M00147_1 tf 1 Factor: HSF2; motif: NGAANNWTCK; match class: 1 1 Q7L9B9,P12931 270 3.84e-02 56 2 1 0.500 0.018 KEGG:04917 keg 1 Prolactin signaling pathway 1 P12931 270 3.85e-02 30 2 1 0.500 0.033 GO:0030520 BP 1 intracellular estrogen receptor signaling pathway 1 P12931 270 3.98e-02 31 2 1 0.500 0.032 GO:0038128 BP 1 ERBB2 signaling pathway 1 P12931 270 3.98e-02 31 2 1 0.500 0.032 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 P12931 270 3.98e-02 58 2 1 0.500 0.017 KEGG:05120 keg 1 Epithelial cell signaling in Helicobacter pylori infection 1 P12931 270 4.06e-02 43 2 1 0.500 0.023 REAC:1227986 rea 1 Signaling by ERBB2 1 P12931 270 4.10e-02 91 2 1 0.500 0.011 TF:M06051_0 tf 1 Factor: ZNF208; motif: NGGGGGGGTGGA; match class: 0 1 P12931 270 4.10e-02 32 2 1 0.500 0.031 GO:0051219 MF 1 phosphoprotein binding 1 P12931 270 4.15e-02 92 2 1 0.500 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 P12931 270 4.23e-02 33 2 1 0.500 0.030 GO:0051893 BP 1 regulation of focal adhesion assembly 1 P12931 270 4.23e-02 33 2 1 0.500 0.030 GO:0090109 BP 1 regulation of cell-substrate junction assembly 1 P12931 270 4.23e-02 33 2 1 0.500 0.030 GO:1901654 BP 1 response to ketone 1 P12931 270 4.23e-02 33 2 1 0.500 0.030 GO:0045022 BP 1 early endosome to late endosome transport 1 P12931 270 4.25e-02 62 2 1 0.500 0.016 KEGG:05131 keg 1 Shigellosis 1 P12931 270 4.36e-02 34 2 1 0.500 0.029 GO:0051972 BP 1 regulation of telomerase activity 1 P12931 270 4.37e-02 97 2 1 0.500 0.010 TF:M00068_0 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 0 1 Q7L9B9 270 4.49e-02 35 2 1 0.500 0.029 GO:0098927 BP 1 vesicle-mediated transport between endosomal compartments 1 P12931 270 4.49e-02 35 2 1 0.500 0.029 GO:0020037 MF 1 heme binding 1 P12931 270 4.49e-02 35 2 1 0.500 0.029 GO:1903391 BP 1 regulation of adherens junction organization 1 P12931 270 4.62e-02 36 2 1 0.500 0.028 GO:0004715 MF 1 non-membrane spanning protein tyrosine kinase activity 1 P12931 270 4.66e-02 68 2 1 0.500 0.015 KEGG:04727 keg 1 GABAergic synapse 1 P12931 270 4.74e-02 37 2 1 0.500 0.027 GO:0046906 MF 1 tetrapyrrole binding 1 P12931 270 4.74e-02 37 2 1 0.500 0.027 GO:0038083 BP 1 peptidyl-tyrosine autophosphorylation 1 P12931 270 4.74e-02 37 2 1 0.500 0.027 GO:0051897 BP 1 positive regulation of protein kinase B signaling 1 P12931 270 4.80e-02 70 2 1 0.500 0.014 KEGG:04520 keg 1 Adherens junction 1 P12931 270 4.87e-02 38 2 1 0.500 0.026 GO:0048771 BP 1 tissue remodeling 1 P12931 270 4.87e-02 38 2 1 0.500 0.026 GO:0005070 MF 1 SH3/SH2 adaptor activity 1 P12931 270 4.92e-02 1665 2 2 1.000 0.001 TF:M01224_0 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 0 1 Q7L9B9,P12931 270 4.93e-02 72 2 1 0.500 0.014 KEGG:04750 keg 1 Inflammatory mediator regulation of TRP channels 1 P12931 270 5.00e-02 53 2 1 0.500 0.019 REAC:388841 rea 1 Costimulation by the CD28 family 1 P12931 270 5.00e-02 39 2 1 0.500 0.026 GO:0031295 BP 1 T cell costimulation 1 P12931 270 5.00e-02 39 2 1 0.500 0.026 GO:0031294 BP 1 lymphocyte costimulation 1 P12931 270 5.00e-02 11 2 1 0.500 0.091 CORUM:5177 cor 1 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 1 P12931 270 5.00e-02 111 2 1 0.500 0.009 TF:M04197_0 tf 1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 0 1 Q7L9B9 270 5.00e-02 73 2 1 0.500 0.014 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 P12931 270 5.00e-02 73 2 1 0.500 0.014 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 P12931 271 7.00e-06 96 4 3 0.750 0.031 GO:0006900 BP 1 membrane budding 1 Q92734,Q9Y3E7,Q9HD42 271 2.22e-05 13 4 2 0.500 0.154 GO:1901673 BP 1 regulation of mitotic spindle assembly 1 Q9Y3E7,Q9HD42 271 2.98e-05 15 4 2 0.500 0.133 GO:0090169 BP 1 regulation of spindle assembly 1 Q9Y3E7,Q9HD42 271 3.86e-05 17 4 2 0.500 0.118 GO:0000920 BP 1 cell separation after cytokinesis 1 Q9Y3E7,Q9HD42 271 5.39e-05 20 4 2 0.500 0.100 GO:0060236 BP 1 regulation of mitotic spindle organization 1 Q9Y3E7,Q9HD42 271 6.55e-05 22 4 2 0.500 0.091 GO:0039702 BP 1 viral budding via host ESCRT complex 1 Q9Y3E7,Q9HD42 271 6.55e-05 22 4 2 0.500 0.091 GO:0090224 BP 1 regulation of spindle organization 1 Q9Y3E7,Q9HD42 271 8.51e-05 25 4 2 0.500 0.080 GO:1902590 BP 1 multi-organism organelle organization 1 Q9Y3E7,Q9HD42 271 8.51e-05 25 4 2 0.500 0.080 GO:0046755 BP 1 viral budding 1 Q9Y3E7,Q9HD42 271 8.51e-05 25 4 2 0.500 0.080 GO:1902592 BP 1 multi-organism membrane budding 1 Q9Y3E7,Q9HD42 271 1.15e-04 29 4 2 0.500 0.069 GO:0010824 BP 1 regulation of centrosome duplication 1 Q9Y3E7,Q9HD42 271 1.23e-04 30 4 2 0.500 0.067 GO:0036258 BP 1 multivesicular body assembly 1 Q9Y3E7,Q9HD42 271 1.23e-04 30 4 2 0.500 0.067 GO:0044803 BP 1 multi-organism membrane organization 1 Q9Y3E7,Q9HD42 271 1.32e-04 31 4 2 0.500 0.065 GO:0036257 BP 1 multivesicular body organization 1 Q9Y3E7,Q9HD42 271 1.69e-04 35 4 2 0.500 0.057 GO:0046605 BP 1 regulation of centrosome cycle 1 Q9Y3E7,Q9HD42 271 1.77e-04 281 4 3 0.750 0.011 GO:0016050 BP 1 vesicle organization 1 Q92734,Q9Y3E7,Q9HD42 271 1.78e-04 36 4 2 0.500 0.056 GO:0019068 BP 1 virion assembly 1 Q9Y3E7,Q9HD42 271 1.93e-04 289 4 3 0.750 0.010 GO:0051656 BP 1 establishment of organelle localization 1 Q92734,Q9Y3E7,Q9HD42 271 2.32e-04 41 4 2 0.500 0.049 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q9Y3E7,Q9HD42 271 2.89e-04 331 4 3 0.750 0.009 GO:0051640 BP 1 organelle localization 1 Q92734,Q9Y3E7,Q9HD42 271 3.19e-04 48 4 2 0.500 0.042 GO:0051310 BP 1 metaphase plate congression 1 Q9Y3E7,Q9HD42 271 3.90e-04 53 4 2 0.500 0.038 GO:0090307 BP 1 mitotic spindle assembly 1 Q9Y3E7,Q9HD42 271 4.05e-04 54 4 2 0.500 0.037 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 Q9Y3E7,Q9HD42 271 4.05e-04 54 4 2 0.500 0.037 GO:0051298 BP 1 centrosome duplication 1 Q9Y3E7,Q9HD42 271 4.20e-04 55 4 2 0.500 0.036 GO:0051303 BP 1 establishment of chromosome localization 1 Q9Y3E7,Q9HD42 271 4.35e-04 56 4 2 0.500 0.036 GO:0050000 BP 1 chromosome localization 1 Q9Y3E7,Q9HD42 271 5.17e-04 61 4 2 0.500 0.033 GO:0007032 BP 1 endosome organization 1 Q9Y3E7,Q9HD42 271 6.24e-04 67 4 2 0.500 0.030 GO:0007098 BP 1 centrosome cycle 1 Q9Y3E7,Q9HD42 271 8.04e-04 76 4 2 0.500 0.026 GO:0051225 BP 1 spindle assembly 1 Q9Y3E7,Q9HD42 271 9.82e-04 84 4 2 0.500 0.024 GO:0070507 BP 1 regulation of microtubule cytoskeleton organization 1 Q9Y3E7,Q9HD42 271 1.08e-03 88 4 2 0.500 0.023 GO:0007052 BP 1 mitotic spindle organization 1 Q9Y3E7,Q9HD42 271 1.09e-03 1 4 1 0.250 1.000 GO:0045013 BP 1 carbon catabolite repression of transcription 1 Q9HD42 271 1.09e-03 1 4 1 0.250 1.000 GO:0045014 BP 1 negative regulation of transcription by glucose 1 Q9HD42 271 1.31e-03 97 4 2 0.500 0.021 GO:0051297 BP 1 centrosome organization 1 Q9Y3E7,Q9HD42 271 1.42e-03 101 4 2 0.500 0.020 GO:0007088 BP 1 regulation of mitotic nuclear division 1 Q9Y3E7,Q9HD42 271 1.48e-03 103 4 2 0.500 0.019 GO:0006997 BP 1 nucleus organization 1 Q9Y3E7,Q9HD42 271 1.51e-03 104 4 2 0.500 0.019 GO:0032886 BP 1 regulation of microtubule-based process 1 Q9Y3E7,Q9HD42 271 1.56e-03 106 4 2 0.500 0.019 GO:0031023 BP 1 microtubule organizing center organization 1 Q9Y3E7,Q9HD42 271 1.59e-03 107 4 2 0.500 0.019 GO:0051783 BP 1 regulation of nuclear division 1 Q9Y3E7,Q9HD42 271 1.95e-03 1 4 1 0.250 1.000 OMIM:604484 omi 1 NEUROPATHY, HEREDITARY MOTOR AND SENSORY, OKINAWA TYPE; HMSNO;;HEREDITARY MOTOR AND SENSORY NEUROPATHY, PROXIMAL TYPE, FORMERLY;HMSNP, FORMERLY 1 Q92734 271 1.95e-03 1 4 1 0.250 1.000 OMIM:614961 omi 1 PONTOCEREBELLAR HYPOPLASIA, TYPE 8; PCH8 1 Q9HD42 271 1.95e-03 1 4 1 0.250 1.000 OMIM:615658 omi 1 SPASTIC PARAPLEGIA 57, AUTOSOMAL RECESSIVE; SPG57 1 Q92734 271 1.97e-03 119 4 2 0.500 0.017 GO:0000070 BP 1 mitotic sister chromatid segregation 1 Q9Y3E7,Q9HD42 271 2.10e-03 123 4 2 0.500 0.016 GO:0007051 BP 1 spindle organization 1 Q9Y3E7,Q9HD42 271 2.12e-03 647 4 3 0.750 0.005 GO:0042802 MF 1 identical protein binding 1 Q92734,Q9Y3E7,Q9HD42 271 2.19e-03 2 4 1 0.250 0.500 GO:0061763 BP 1 multivesicular body-lysosome fusion 1 Q9Y3E7 271 2.19e-03 2 4 1 0.250 0.500 GO:0051469 BP 1 vesicle fusion with vacuole 1 Q9Y3E7 271 2.35e-03 130 4 2 0.500 0.015 GO:1902115 BP 1 regulation of organelle assembly 1 Q9Y3E7,Q9HD42 271 3.27e-03 749 4 3 0.750 0.004 GO:0061024 BP 1 membrane organization 1 Q92734,Q9Y3E7,Q9HD42 271 3.64e-03 281 4 2 0.500 0.007 MI:hsa-miR-144* mi 1 MI:hsa-miR-144* 1 Q92734,Q9Y3E7 271 3.82e-03 166 4 2 0.500 0.012 GO:0051301 BP 1 cell division 1 Q9Y3E7,Q9HD42 271 4.37e-03 4 4 1 0.250 0.250 GO:0032510 BP 1 endosome to lysosome transport via multivesicular body sorting pathway 1 Q9Y3E7 271 4.37e-03 4 4 1 0.250 0.250 GO:0046015 BP 1 regulation of transcription by glucose 1 Q9HD42 271 4.37e-03 4 4 1 0.250 0.250 GO:0045990 BP 1 carbon catabolite regulation of transcription 1 Q9HD42 271 5.31e-03 196 4 2 0.500 0.010 GO:0000819 BP 1 sister chromatid segregation 1 Q9Y3E7,Q9HD42 271 6.38e-03 374 4 2 0.500 0.005 MI:hsa-miR-633 mi 1 MI:hsa-miR-633 1 O15321,Q92734 271 6.76e-03 958 4 3 0.750 0.003 GO:0016192 BP 1 vesicle-mediated transport 1 Q92734,Q9Y3E7,Q9HD42 271 7.04e-03 226 4 2 0.500 0.009 GO:0098813 BP 1 nuclear chromosome segregation 1 Q9Y3E7,Q9HD42 271 7.67e-03 236 4 2 0.500 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q9Y3E7,Q9HD42 271 8.01e-03 1015 4 3 0.750 0.003 GO:0071822 BP 1 protein complex subunit organization 1 Q92734,Q9Y3E7,Q9HD42 271 8.77e-03 440 4 2 0.500 0.005 MI:hsa-miR-581 mi 1 MI:hsa-miR-581 1 O15321,Q92734 271 9.50e-03 263 4 2 0.500 0.008 GO:0007059 BP 1 chromosome segregation 1 Q9Y3E7,Q9HD42 271 9.65e-03 265 4 2 0.500 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q9Y3E7,Q9HD42 271 1.09e-02 10 4 1 0.250 0.100 GO:0032509 BP 1 endosome transport via multivesicular body sorting pathway 1 Q9Y3E7 271 1.09e-02 10 4 1 0.250 0.100 GO:0000815 CC 1 ESCRT III complex 1 Q9Y3E7 271 1.09e-02 10 4 1 0.250 0.100 GO:1904896 BP 1 ESCRT complex disassembly 1 Q9HD42 271 1.09e-02 10 4 1 0.250 0.100 GO:1904903 BP 1 ESCRT III complex disassembly 1 Q9HD42 271 1.11e-02 1578 4 3 0.750 0.002 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 O15321,Q92734,Q9Y3E7 271 1.15e-02 507 4 2 0.500 0.004 MI:hsa-miR-768-3p mi 1 MI:hsa-miR-768-3p 1 O15321,Q92734 271 1.19e-02 514 4 2 0.500 0.004 MI:hsa-miR-320 mi 1 MI:hsa-miR-320 1 O15321,Q92734 271 1.20e-02 11 4 1 0.250 0.091 GO:0071985 BP 1 multivesicular body sorting pathway 1 Q9Y3E7 271 1.20e-02 11 4 1 0.250 0.091 GO:1902187 BP 1 negative regulation of viral release from host cell 1 Q9Y3E7 271 1.31e-02 309 4 2 0.500 0.006 GO:0000280 BP 1 nuclear division 1 Q9Y3E7,Q9HD42 271 1.31e-02 12 4 1 0.250 0.083 GO:1902188 BP 1 positive regulation of viral release from host cell 1 Q9Y3E7 271 1.31e-02 12 4 1 0.250 0.083 GO:0007076 BP 1 mitotic chromosome condensation 1 Q9HD42 271 1.31e-02 12 4 1 0.250 0.083 GO:1990381 MF 1 ubiquitin-specific protease binding 1 Q9Y3E7 271 1.36e-02 531 4 2 0.500 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.39e-02 537 4 2 0.500 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.42e-02 13 4 1 0.250 0.077 GO:0050997 MF 1 quaternary ammonium group binding 1 Q9Y3E7 271 1.42e-02 13 4 1 0.250 0.077 GO:0031210 MF 1 phosphatidylcholine binding 1 Q9Y3E7 271 1.49e-02 330 4 2 0.500 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q9Y3E7,Q9HD42 271 1.53e-02 14 4 1 0.250 0.071 GO:0031670 BP 1 cellular response to nutrient 1 Q9HD42 271 1.54e-02 567 4 2 0.500 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.58e-02 340 4 2 0.500 0.006 GO:0048285 BP 1 organelle fission 1 Q9Y3E7,Q9HD42 271 1.58e-02 341 4 2 0.500 0.006 GO:0019058 BP 1 viral life cycle 1 Q9Y3E7,Q9HD42 271 1.69e-02 596 4 2 0.500 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.75e-02 16 4 1 0.250 0.062 GO:1903541 BP 1 regulation of exosomal secretion 1 Q9Y3E7 271 1.79e-02 363 4 2 0.500 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q9Y3E7,Q9HD42 271 1.81e-02 616 4 2 0.500 0.003 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.83e-02 24 4 1 0.250 0.042 REAC:162588 rea 1 Budding and maturation of HIV virion 1 Q9Y3E7 271 1.85e-02 624 4 2 0.500 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.85e-02 17 4 1 0.250 0.059 GO:2000641 BP 1 regulation of early endosome to late endosome transport 1 Q9Y3E7 271 1.86e-02 625 4 2 0.500 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 1.89e-02 373 4 2 0.500 0.005 GO:0016032 BP 1 viral process 1 Q9Y3E7,Q9HD42 271 1.91e-02 375 4 2 0.500 0.005 GO:0044764 BP 1 multi-organism cellular process 1 Q9Y3E7,Q9HD42 271 1.96e-02 18 4 1 0.250 0.056 GO:0030261 BP 1 chromosome condensation 1 Q9HD42 271 2.02e-02 386 4 2 0.500 0.005 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 Q9Y3E7,Q9HD42 271 2.02e-02 386 4 2 0.500 0.005 GO:0044419 BP 1 interspecies interaction between organisms 1 Q9Y3E7,Q9HD42 271 2.06e-02 27 4 1 0.250 0.037 REAC:917729 rea 1 Endosomal Sorting Complex Required For Transport (ESCRT) 1 Q9Y3E7 271 2.07e-02 19 4 1 0.250 0.053 GO:1990182 BP 1 exosomal secretion 1 Q9Y3E7 271 2.07e-02 19 4 1 0.250 0.053 GO:0097734 BP 1 extracellular exosome biogenesis 1 Q9Y3E7 271 2.18e-02 20 4 1 0.250 0.050 GO:1903649 BP 1 regulation of cytoplasmic transport 1 Q9Y3E7 271 2.19e-02 402 4 2 0.500 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 Q9Y3E7,Q9HD42 271 2.21e-02 404 4 2 0.500 0.005 GO:0010256 BP 1 endomembrane system organization 1 Q9Y3E7,Q9HD42 271 2.47e-02 1493 4 3 0.750 0.002 GO:0051649 BP 1 establishment of localization in cell 1 Q92734,Q9Y3E7,Q9HD42 271 2.50e-02 2 4 1 0.250 0.500 HP:0002378 hp 1 Hand tremor 1 Q92734 271 2.52e-02 13 4 1 0.250 0.077 OMIM:607596 omi 1 Pontocerebellar Hypoplasia 1 Q9HD42 271 2.65e-02 753 4 2 0.500 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 2.67e-02 755 4 2 0.500 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 O15321,Q9Y3E7 271 2.67e-02 445 4 2 0.500 0.004 GO:0070925 BP 1 organelle assembly 1 Q9Y3E7,Q9HD42 271 2.67e-02 445 4 2 0.500 0.004 GO:0042803 MF 1 protein homodimerization activity 1 Q9Y3E7,Q9HD42 271 2.68e-02 446 4 2 0.500 0.004 GO:0051276 BP 1 chromosome organization 1 Q9Y3E7,Q9HD42 271 2.72e-02 25 4 1 0.250 0.040 GO:1902186 BP 1 regulation of viral release from host cell 1 Q9Y3E7 271 2.72e-02 25 4 1 0.250 0.040 GO:0097352 BP 1 autophagosome maturation 1 Q9Y3E7 271 2.72e-02 25 4 1 0.250 0.040 GO:0036452 CC 1 ESCRT complex 1 Q9Y3E7 271 2.83e-02 26 4 1 0.250 0.038 GO:0007584 BP 1 response to nutrient 1 Q9HD42 271 2.83e-02 459 4 2 0.500 0.004 GO:0007017 BP 1 microtubule-based process 1 Q9Y3E7,Q9HD42 271 2.92e-02 466 4 2 0.500 0.004 GO:0005768 CC 1 endosome 1 Q9Y3E7,Q9HD42 271 2.94e-02 27 4 1 0.250 0.037 GO:0097576 BP 1 vacuole fusion 1 Q9Y3E7 271 3.09e-02 1614 4 3 0.750 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q92734,Q9Y3E7,Q9HD42 271 3.15e-02 2274 4 3 0.750 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 O15321,Q92734,Q9Y3E7 271 3.16e-02 29 4 1 0.250 0.034 GO:0052192 BP 1 movement in environment of other organism involved in symbiotic interaction 1 Q9Y3E7 271 3.16e-02 29 4 1 0.250 0.034 GO:0019076 BP 1 viral release from host cell 1 Q9Y3E7 271 3.16e-02 29 4 1 0.250 0.034 GO:0052126 BP 1 movement in host environment 1 Q9Y3E7 271 3.16e-02 29 4 1 0.250 0.034 GO:0035891 BP 1 exit from host cell 1 Q9Y3E7 271 3.16e-02 29 4 1 0.250 0.034 GO:0035890 BP 1 exit from host 1 Q9Y3E7 271 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 3.40e-02 504 4 2 0.500 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9Y3E7,Q9HD42 271 3.40e-02 985 4 3 0.750 0.003 TF:M02102_1 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 1 Q92734,Q9Y3E7,Q9HD42 271 3.52e-02 874 4 2 0.500 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 3.59e-02 33 4 1 0.250 0.030 GO:0051291 BP 1 protein heterooligomerization 1 Q9Y3E7 271 3.59e-02 33 4 1 0.250 0.030 GO:0045022 BP 1 early endosome to late endosome transport 1 Q9Y3E7 271 3.62e-02 1706 4 3 0.750 0.002 GO:0022607 BP 1 cellular component assembly 1 Q92734,Q9Y3E7,Q9HD42 271 3.68e-02 6 4 1 0.250 0.167 TF:M06084_1 tf 1 Factor: ZNF208; motif: NSGGGAAGRGGT; match class: 1 1 Q9HD42 271 3.73e-02 902 4 2 0.500 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 O15321,Q9Y3E7 271 3.77e-02 906 4 2 0.500 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 O15321,Q9Y3E7 271 3.81e-02 35 4 1 0.250 0.029 GO:0008333 BP 1 endosome to lysosome transport 1 Q9Y3E7 271 3.81e-02 35 4 1 0.250 0.029 GO:0098927 BP 1 vesicle-mediated transport between endosomal compartments 1 Q9Y3E7 271 3.82e-02 233 4 2 0.500 0.009 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 O15321,Q9HD42 271 3.87e-02 919 4 2 0.500 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 O15321,Q9Y3E7 271 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 3.93e-02 522 4 2 0.500 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q92734,Q9Y3E7 271 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 O15321,Q9Y3E7 271 4.13e-02 38 4 1 0.250 0.026 GO:0070405 MF 1 ammonium ion binding 1 Q9Y3E7 271 4.17e-02 560 4 2 0.500 0.004 GO:0046983 MF 1 protein dimerization activity 1 Q9Y3E7,Q9HD42 271 4.33e-02 549 4 2 0.500 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q92734,Q9Y3E7 271 4.47e-02 1836 4 3 0.750 0.002 GO:0051641 BP 1 cellular localization 1 Q92734,Q9Y3E7,Q9HD42 271 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 O15321,Q9Y3E7 271 4.55e-02 1002 4 2 0.500 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 O15321,Q9Y3E7 271 4.55e-02 60 4 1 0.250 0.017 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 Q92734 271 4.99e-02 1122 4 3 0.750 0.003 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 O15321,Q92734,Q9HD42 271 5.00e-02 229 4 2 0.500 0.009 KEGG:04144 keg 1 Endocytosis 1 Q9Y3E7,Q9HD42 271 5.00e-02 10 4 2 0.500 0.200 CORUM:1186 cor 1 ESCRT-III complex 1 Q9Y3E7,Q9HD42 271 5.00e-02 26 4 1 0.250 0.038 OMIM:270800 omi 1 Autosomal Recessive Spastic Paraplegia 1 Q92734 271 5.00e-02 267 4 2 0.500 0.007 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 Q92734,Q9HD42 271 5.00e-02 46 4 1 0.250 0.022 GO:0016363 CC 1 nuclear matrix 1 Q9HD42 271 5.00e-02 4 4 1 0.250 0.250 HP:0004684 hp 1 Talipes valgus 1 Q9HD42 271 5.00e-02 66 4 1 0.250 0.015 REAC:1632852 rea 1 Macroautophagy 1 Q9Y3E7 271 5.00e-02 267 4 2 0.500 0.007 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 Q92734,Q9HD42 272 7.21e-03 2 4 1 0.250 0.500 GO:0033018 CC 1 sarcoplasmic reticulum lumen 1 O14958 272 7.49e-03 406 4 2 0.500 0.005 MI:mmu-miR-680 mi 1 MI:mmu-miR-680 1 Q9Y576,Q96NA8 272 7.60e-03 409 4 2 0.500 0.005 MI:hsa-miR-375 mi 1 MI:hsa-miR-375 1 Q9Y576,Q96NA8 272 7.71e-03 412 4 2 0.500 0.005 MI:hsa-miR-923 mi 1 MI:hsa-miR-923 1 Q9Y576,Q96NA8 272 8.50e-03 433 4 2 0.500 0.005 MI:hsa-miR-423-3p mi 1 MI:hsa-miR-423-3p 1 Q9Y576,Q96NA8 272 8.81e-03 441 4 2 0.500 0.005 MI:mmu-miR-763 mi 1 MI:mmu-miR-763 1 Q9Y576,Q96NA8 272 9.48e-03 458 4 2 0.500 0.004 MI:hsa-miR-24 mi 1 MI:hsa-miR-24 1 Q9Y576,Q96NA8 272 1.08e-02 3 4 1 0.250 0.333 GO:0086029 BP 1 Purkinje myocyte to ventricular cardiac muscle cell signaling 1 O14958 272 1.08e-02 3 4 1 0.250 0.333 GO:0086068 BP 1 Purkinje myocyte to ventricular cardiac muscle cell communication 1 O14958 272 1.19e-02 516 4 2 0.500 0.004 MI:mmu-miR-673-5p mi 1 MI:mmu-miR-673-5p 1 Q9Y576,Q96NA8 272 1.44e-02 4 4 1 0.250 0.250 GO:0051549 BP 1 positive regulation of keratinocyte migration 1 Q9H329 272 1.44e-02 4 4 1 0.250 0.250 GO:0051547 BP 1 regulation of keratinocyte migration 1 Q9H329 272 2.16e-02 6 4 1 0.250 0.167 GO:0031000 BP 1 response to caffeine 1 O14958 272 2.16e-02 6 4 1 0.250 0.167 GO:0071313 BP 1 cellular response to caffeine 1 O14958 272 2.16e-02 6 4 1 0.250 0.167 GO:0005513 BP 1 detection of calcium ion 1 O14958 272 2.16e-02 6 4 1 0.250 0.167 GO:0014701 CC 1 junctional sarcoplasmic reticulum membrane 1 O14958 272 2.50e-02 1 4 1 0.250 1.000 OMIM:611938 omi 1 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 2; CPVT2;;VENTRICULAR TACHYCARDIA, STRESS-INDUCED POLYMORPHIC; VTSIP 1 O14958 272 2.52e-02 7 4 1 0.250 0.143 GO:0051546 BP 1 keratinocyte migration 1 Q9H329 272 2.52e-02 7 4 1 0.250 0.143 GO:0071415 BP 1 cellular response to purine-containing compound 1 O14958 272 2.52e-02 7 4 1 0.250 0.143 GO:0010649 BP 1 regulation of cell communication by electrical coupling 1 O14958 272 2.88e-02 8 4 1 0.250 0.125 GO:0060315 BP 1 negative regulation of ryanodine-sensitive calcium-release channel activity 1 O14958 272 2.88e-02 8 4 1 0.250 0.125 GO:1901017 BP 1 negative regulation of potassium ion transmembrane transporter activity 1 O14958 272 2.88e-02 8 4 1 0.250 0.125 GO:0051280 BP 1 negative regulation of release of sequestered calcium ion into cytosol 1 O14958 272 3.24e-02 9 4 1 0.250 0.111 GO:0010523 BP 1 negative regulation of calcium ion transport into cytosol 1 O14958 272 3.24e-02 9 4 1 0.250 0.111 GO:0051284 BP 1 positive regulation of sequestering of calcium ion 1 O14958 272 3.60e-02 10 4 1 0.250 0.100 GO:1901380 BP 1 negative regulation of potassium ion transmembrane transport 1 O14958 272 3.96e-02 11 4 1 0.250 0.091 GO:0090281 BP 1 negative regulation of calcium ion import 1 O14958 272 4.32e-02 12 4 1 0.250 0.083 GO:0042036 BP 1 negative regulation of cytokine biosynthetic process 1 Q9Y576 272 4.32e-02 12 4 1 0.250 0.083 GO:0050849 BP 1 negative regulation of calcium-mediated signaling 1 O14958 272 4.32e-02 12 4 1 0.250 0.083 GO:0043267 BP 1 negative regulation of potassium ion transport 1 O14958 272 4.68e-02 13 4 1 0.250 0.077 GO:0010881 BP 1 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1 O14958 272 4.68e-02 13 4 1 0.250 0.077 GO:0086019 BP 1 cell-cell signaling involved in cardiac conduction 1 O14958 272 5.00e-02 2 4 1 0.250 0.500 OMIM:604772 omi 1 Catecholaminergic Polymorphic Ventricular Tachycardia 1 O14958 272 5.00e-02 4 4 1 0.250 0.250 CORUM:208 cor 1 Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) 1 Q9Y576 272 5.00e-02 210 4 2 0.500 0.010 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 O14958,Q96NA8 272 5.00e-02 1263 4 3 0.750 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 Q9Y576,Q9H329,O14958 273 6.61e-09 16 3 3 1.000 0.188 GO:0035098 CC 1 ESC/E(Z) complex 1 O75530,Q5T6S3,Q9Y483 273 1.34e-07 27 3 3 1.000 0.111 REAC:212300 rea 1 PRC2 methylates histones and DNA 1 O75530,Q5T6S3,Q9Y483 273 1.46e-07 43 3 3 1.000 0.070 GO:0031519 CC 1 PcG protein complex 1 O75530,Q5T6S3,Q9Y483 273 5.92e-07 68 3 3 1.000 0.044 GO:0035097 CC 1 histone methyltransferase complex 1 O75530,Q5T6S3,Q9Y483 273 6.19e-07 69 3 3 1.000 0.043 GO:0045814 BP 1 negative regulation of gene expression, epigenetic 1 O75530,Q5T6S3,Q9Y483 273 1.25e-06 87 3 3 1.000 0.034 GO:0034708 CC 1 methyltransferase complex 1 O75530,Q5T6S3,Q9Y483 273 1.36e-06 5 3 2 0.667 0.400 GO:0061087 BP 1 positive regulation of histone H3-K27 methylation 1 Q5T6S3,Q9Y483 273 2.86e-06 7 3 2 0.667 0.286 GO:0061085 BP 1 regulation of histone H3-K27 methylation 1 Q5T6S3,Q9Y483 273 6.13e-06 10 3 2 0.667 0.200 GO:0070734 BP 1 histone H3-K27 methylation 1 Q5T6S3,Q9Y483 273 7.65e-06 101 3 3 1.000 0.030 REAC:212165 rea 1 Epigenetic regulation of gene expression 1 O75530,Q5T6S3,Q9Y483 273 1.15e-05 181 3 3 1.000 0.017 GO:0040029 BP 1 regulation of gene expression, epigenetic 1 O75530,Q5T6S3,Q9Y483 273 3.44e-05 23 3 2 0.667 0.087 GO:0031062 BP 1 positive regulation of histone methylation 1 Q5T6S3,Q9Y483 273 7.63e-05 34 3 2 0.667 0.059 GO:0031060 BP 1 regulation of histone methylation 1 Q5T6S3,Q9Y483 273 1.17e-04 42 3 2 0.667 0.048 GO:0035064 MF 1 methylated histone binding 1 Q5T6S3,Q9Y483 273 1.80e-04 52 3 2 0.667 0.038 GO:0031058 BP 1 positive regulation of histone modification 1 Q5T6S3,Q9Y483 273 2.09e-04 56 3 2 0.667 0.036 GO:0034968 BP 1 histone lysine methylation 1 Q5T6S3,Q9Y483 273 2.17e-04 57 3 2 0.667 0.035 GO:1905269 BP 1 positive regulation of chromatin organization 1 Q5T6S3,Q9Y483 273 2.77e-04 521 3 3 1.000 0.006 GO:0044451 CC 1 nucleoplasm part 1 O75530,Q5T6S3,Q9Y483 273 2.82e-04 65 3 2 0.667 0.031 GO:0018022 BP 1 peptidyl-lysine methylation 1 Q5T6S3,Q9Y483 273 3.47e-04 72 3 2 0.667 0.028 GO:0016571 BP 1 histone methylation 1 Q5T6S3,Q9Y483 273 3.97e-04 77 3 2 0.667 0.026 GO:0031056 BP 1 regulation of histone modification 1 Q5T6S3,Q9Y483 273 4.76e-04 624 3 3 1.000 0.005 GO:1990234 CC 1 transferase complex 1 O75530,Q5T6S3,Q9Y483 273 5.92e-04 94 3 2 0.667 0.021 GO:0008213 BP 1 protein alkylation 1 Q5T6S3,Q9Y483 273 5.92e-04 94 3 2 0.667 0.021 GO:0006479 BP 1 protein methylation 1 Q5T6S3,Q9Y483 273 6.31e-04 97 3 2 0.667 0.021 GO:1902275 BP 1 regulation of chromatin organization 1 Q5T6S3,Q9Y483 273 1.12e-03 129 3 2 0.667 0.016 GO:0042393 MF 1 histone binding 1 Q5T6S3,Q9Y483 273 1.25e-03 861 3 3 1.000 0.003 GO:0010629 BP 1 negative regulation of gene expression 1 O75530,Q5T6S3,Q9Y483 273 1.83e-03 165 3 2 0.667 0.012 GO:0043414 BP 1 macromolecule methylation 1 Q5T6S3,Q9Y483 273 2.09e-03 1614 3 3 1.000 0.002 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 2.16e-03 1033 3 3 1.000 0.003 GO:1902494 CC 1 catalytic complex 1 O75530,Q5T6S3,Q9Y483 273 2.27e-03 184 3 2 0.667 0.011 GO:0032259 BP 1 methylation 1 Q5T6S3,Q9Y483 273 2.42e-03 10 3 1 0.333 0.100 TF:M03942_0 tf 1 Factor: ZSCAN4; motif: TGCACACACTGAAAA; match class: 0 1 Q5T6S3 273 3.14e-03 4 3 1 0.333 0.250 GO:0061086 BP 1 negative regulation of histone H3-K27 methylation 1 Q9Y483 273 3.14e-03 4 3 1 0.333 0.250 GO:0007379 BP 1 segment specification 1 Q9Y483 273 4.49e-03 1317 3 3 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 O75530,Q5T6S3,Q9Y483 273 4.59e-03 19 3 1 0.333 0.053 TF:M06575_0 tf 1 Factor: ZNF845; motif: KGGGWTGATTCC; match class: 0 1 Q5T6S3 273 5.27e-03 281 3 2 0.667 0.007 GO:0016570 BP 1 histone modification 1 Q5T6S3,Q9Y483 273 5.61e-03 290 3 2 0.667 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q5T6S3,Q9Y483 273 5.62e-03 552 3 2 0.667 0.004 TF:M00104_1 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 1 1 O75530,Q5T6S3 273 5.67e-03 1424 3 3 1.000 0.002 GO:0009892 BP 1 negative regulation of metabolic process 1 O75530,Q5T6S3,Q9Y483 273 5.85e-03 296 3 2 0.667 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q5T6S3,Q9Y483 273 6.36e-03 588 3 2 0.667 0.003 TF:M01252_1 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 1 1 O75530,Q9Y483 273 6.76e-03 28 3 1 0.333 0.036 TF:M06940_0 tf 1 Factor: ATF-3; motif: TCTATGTAATMW; match class: 0 1 O75530 273 8.21e-03 2546 3 3 1.000 0.001 TF:M00941_0 tf 1 Factor: MEF-2; motif: RGCTATWTTTAR; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 8.63e-03 11 3 1 0.333 0.091 GO:0031061 BP 1 negative regulation of histone methylation 1 Q9Y483 273 1.09e-02 2797 3 3 1.000 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 1.16e-02 48 3 1 0.333 0.021 TF:M05921_0 tf 1 Factor: ZFP14; motif: KGGTGAAAAATA; match class: 0 1 O75530 273 1.18e-02 49 3 1 0.333 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 Q5T6S3 273 1.21e-02 50 3 1 0.333 0.020 TF:M05674_0 tf 1 Factor: ZNF235; motif: NGGTTAAAGATM; match class: 0 1 Q9Y483 273 1.24e-02 827 3 2 0.667 0.002 TF:M01251_1 tf 1 Factor: E2F-1; motif: CGAAAMGT; match class: 1 1 O75530,Q9Y483 273 1.27e-02 2941 3 3 1.000 0.001 TF:M00737_0 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 1.33e-02 449 3 2 0.667 0.004 GO:0006325 BP 1 chromatin organization 1 Q5T6S3,Q9Y483 273 1.36e-02 866 3 2 0.667 0.002 TF:M07285_1 tf 1 Factor: ESE-1; motif: NNYTTCCTG; match class: 1 1 O75530,Q5T6S3 273 1.49e-02 62 3 1 0.333 0.016 TF:M06179_0 tf 1 Factor: ZNF445; motif: NGGATAAAGGA; match class: 0 1 O75530 273 1.56e-02 3152 3 3 1.000 0.001 TF:M04379_1 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 1.57e-02 20 3 1 0.333 0.050 GO:0035282 BP 1 segmentation 1 Q9Y483 273 1.70e-02 972 3 2 0.667 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 O75530,Q5T6S3 273 1.72e-02 22 3 1 0.333 0.045 GO:0031057 BP 1 negative regulation of histone modification 1 Q9Y483 273 1.80e-02 75 3 1 0.333 0.013 TF:M04180_0 tf 1 Factor: MNT; motif: NNCACGTGNN; match class: 0 1 Q5T6S3 273 1.81e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 O75530,Q5T6S3,Q9Y483 273 1.87e-02 3348 3 3 1.000 0.001 TF:M01252_0 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 1.97e-02 82 3 1 0.333 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 Q5T6S3 273 2.00e-02 2 3 1 0.333 0.500 CORUM:5521 cor 1 EED-EZH polycomb complex 1 O75530 273 2.02e-02 2173 3 3 1.000 0.001 GO:0010468 BP 1 regulation of gene expression 1 O75530,Q5T6S3,Q9Y483 273 2.17e-02 3520 3 3 1.000 0.001 TF:M04321_1 tf 1 Factor: EVX2; motif: NNTNATTANN; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 2.26e-02 3566 3 3 1.000 0.001 TF:M00050_0 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 2.35e-02 30 3 1 0.333 0.033 GO:1905268 BP 1 negative regulation of chromatin organization 1 Q9Y483 273 2.45e-02 3667 3 3 1.000 0.001 TF:M00739_0 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 2.50e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 O75530,Q5T6S3,Q9Y483 273 2.51e-02 619 3 2 0.667 0.003 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 O75530,Q9Y483 273 2.54e-02 623 3 2 0.667 0.003 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 O75530,Q9Y483 273 2.54e-02 106 3 1 0.333 0.009 TF:M05958_0 tf 1 Factor: ZNF286; motif: NTTGGCGGATGM; match class: 0 1 O75530 273 2.56e-02 1200 3 2 0.667 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 O75530,Q5T6S3 273 2.62e-02 632 3 2 0.667 0.003 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 O75530,Q9Y483 273 2.64e-02 110 3 1 0.333 0.009 TF:M01142_1 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 1 1 Q5T6S3 273 2.67e-02 1225 3 2 0.667 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 O75530,Q5T6S3 273 2.69e-02 1229 3 2 0.667 0.002 TF:M01116_0 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 0 1 Q5T6S3,Q9Y483 273 2.77e-02 650 3 2 0.667 0.003 GO:0031401 BP 1 positive regulation of protein modification process 1 Q5T6S3,Q9Y483 273 2.91e-02 667 3 2 0.667 0.003 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 O75530,Q9Y483 273 3.00e-02 3 3 1 0.333 0.333 CORUM:5502 cor 1 EED-EZH-YY1 polycomb complex 1 O75530 273 3.00e-02 3 3 1 0.333 0.333 CORUM:1177 cor 1 Polycomb repressive complex 4 (PRC4) 1 O75530 273 3.06e-02 1316 3 2 0.667 0.002 TF:M04182_0 tf 1 Factor: NEUROD2; motif: RMCATATGKY; match class: 0 1 Q5T6S3,Q9Y483 273 3.18e-02 2529 3 3 1.000 0.001 GO:0005654 CC 1 nucleoplasm 1 O75530,Q5T6S3,Q9Y483 273 3.23e-02 135 3 1 0.333 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 O75530 273 3.26e-02 707 3 2 0.667 0.003 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q5T6S3,Q9Y483 273 3.33e-02 139 3 1 0.333 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 O75530 273 3.34e-02 4064 3 3 1.000 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 3.35e-02 140 3 1 0.333 0.007 TF:M04091_0 tf 1 Factor: POU6F2; motif: GCTAATTANN; match class: 0 1 Q5T6S3 273 3.35e-02 140 3 1 0.333 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q5T6S3 273 3.38e-02 720 3 2 0.667 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q5T6S3,Q9Y483 273 3.48e-02 4118 3 3 1.000 0.001 TF:M00471_0 tf 1 Factor: TBP; motif: TATAAATW; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 3.53e-02 2618 3 3 1.000 0.001 GO:0048519 BP 1 negative regulation of biological process 1 O75530,Q5T6S3,Q9Y483 273 3.58e-02 4160 3 3 1.000 0.001 TF:M04078_0 tf 1 Factor: POU3F2; motif: NWTGCATAAWTTA; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 3.69e-02 753 3 2 0.667 0.003 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 O75530,Q9Y483 273 3.75e-02 48 3 1 0.333 0.021 GO:0042054 MF 1 histone methyltransferase activity 1 O75530 273 3.80e-02 765 3 2 0.667 0.003 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 O75530,Q9Y483 273 3.86e-02 4263 3 3 1.000 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 3.97e-02 4305 3 3 1.000 0.001 TF:M04081_0 tf 1 Factor: POU3F3; motif: WTGMATAAWTWA; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 3.98e-02 1507 3 2 0.667 0.001 TF:M00403_0 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 0 1 O75530,Q5T6S3 273 4.06e-02 170 3 1 0.333 0.006 TF:M02021_1 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 1 1 Q9Y483 273 4.09e-02 794 3 2 0.667 0.003 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 O75530,Q9Y483 273 4.11e-02 172 3 1 0.333 0.006 TF:M00006_1 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 1 1 O75530 273 4.11e-02 4354 3 3 1.000 0.001 TF:M04334_1 tf 1 Factor: HMX2; motif: ANCAMTTAANN; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 4.21e-02 1553 3 2 0.667 0.001 TF:M00801_1 tf 1 Factor: CREB; motif: CGTCAN; match class: 1 1 O75530,Q5T6S3 273 4.34e-02 182 3 1 0.333 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 Q9Y483 273 4.38e-02 822 3 2 0.667 0.002 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 O75530,Q9Y483 273 4.48e-02 832 3 2 0.667 0.002 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 Q5T6S3,Q9Y483 273 4.50e-02 834 3 2 0.667 0.002 GO:0009890 BP 1 negative regulation of biosynthetic process 1 O75530,Q9Y483 273 4.54e-02 1616 3 2 0.667 0.001 TF:M03833_1 tf 1 Factor: NKX3A; motif: NCACTTANTYN; match class: 1 1 O75530,Q5T6S3 273 4.55e-02 191 3 1 0.333 0.005 TF:M06688_0 tf 1 Factor: ZFP; motif: GACAAAACGA; match class: 0 1 Q9Y483 273 4.61e-02 59 3 1 0.333 0.017 GO:0098727 BP 1 maintenance of cell number 1 Q9Y483 273 4.61e-02 59 3 1 0.333 0.017 GO:0019827 BP 1 stem cell population maintenance 1 Q9Y483 273 4.65e-02 195 3 1 0.333 0.005 TF:M06390_0 tf 1 Factor: ZNF227; motif: RTTCKGAGATN; match class: 0 1 Q9Y483 273 4.69e-02 852 3 2 0.667 0.002 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 O75530,Q9Y483 273 4.70e-02 197 3 1 0.333 0.005 TF:M01212_0 tf 1 Factor: STAT1:STAT1; motif: NTTTCCMGGAAAA; match class: 0 1 O75530 273 4.85e-02 4602 3 3 1.000 0.001 TF:M01855_1 tf 1 Factor: AHR; motif: CACGCN; match class: 1 1 O75530,Q5T6S3,Q9Y483 273 4.90e-02 1681 3 2 0.667 0.001 TF:M01652_0 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 0 1 O75530,Q5T6S3 273 4.95e-02 2931 3 3 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 O75530,Q5T6S3,Q9Y483 273 4.95e-02 208 3 1 0.333 0.005 TF:M06849_0 tf 1 Factor: ZNF528; motif: NSTCCGGAAGA; match class: 0 1 Q9Y483 273 4.98e-02 4643 3 3 1.000 0.001 TF:M03846_0 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 0 1 O75530,Q5T6S3,Q9Y483 273 5.00e-02 5 3 1 0.333 0.200 CORUM:105 cor 1 Polycomb repressive complex 2 (PRC 2) 1 O75530 273 5.00e-02 42 3 1 0.333 0.024 REAC:3214841 rea 1 PKMTs methylate histone lysines 1 O75530 273 5.00e-02 880 3 2 0.667 0.002 GO:0051247 BP 1 positive regulation of protein metabolic process 1 Q5T6S3,Q9Y483 273 5.00e-02 5 3 1 0.333 0.200 CORUM:996 cor 1 Polycomb repressive complex 2 (PRC2) 1 O75530 273 5.00e-02 5 3 1 0.333 0.200 CORUM:995 cor 1 Polycomb repressive complex 3 (PRC3) 1 O75530 273 5.00e-02 5 3 1 0.333 0.200 CORUM:974 cor 1 EED-EZH2 complex 1 O75530 273 5.00e-02 210 3 1 0.333 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 O75530 274 2.44e-05 37 2 2 1.000 0.054 GO:0051492 BP 1 regulation of stress fiber assembly 1 P19634,Q92633 274 3.46e-05 44 2 2 1.000 0.045 GO:0032231 BP 1 regulation of actin filament bundle assembly 1 P19634,Q92633 274 4.13e-05 48 2 2 1.000 0.042 GO:0043149 BP 1 stress fiber assembly 1 P19634,Q92633 274 4.13e-05 48 2 2 1.000 0.042 GO:0030038 BP 1 contractile actin filament bundle assembly 1 P19634,Q92633 274 1.25e-04 83 2 2 1.000 0.024 GO:0051017 BP 1 actin filament bundle assembly 1 P19634,Q92633 274 1.28e-04 84 2 2 1.000 0.024 GO:0061572 BP 1 actin filament bundle organization 1 P19634,Q92633 274 1.53e-04 92 2 2 1.000 0.022 GO:0031032 BP 1 actomyosin structure organization 1 P19634,Q92633 274 4.22e-04 1 2 1 0.500 1.000 GO:0086040 MF 1 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential 1 P19634 274 4.22e-04 1 2 1 0.500 1.000 GO:0086092 BP 1 regulation of the force of heart contraction by cardiac conduction 1 P19634 274 5.26e-04 170 2 2 1.000 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 P19634,Q92633 274 6.78e-04 193 2 2 1.000 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 P19634,Q92633 274 8.19e-04 212 2 2 1.000 0.009 GO:0007015 BP 1 actin filament organization 1 P19634,Q92633 274 8.45e-04 2 2 1 0.500 0.500 GO:1903281 BP 1 positive regulation of calcium:sodium antiporter activity 1 P19634 274 8.45e-04 2 2 1 0.500 0.500 GO:0035727 MF 1 lysophosphatidic acid binding 1 Q92633 274 8.45e-04 2 2 1 0.500 0.500 GO:0070915 MF 1 lysophosphatidic acid receptor activity 1 Q92633 274 9.81e-04 232 2 2 1.000 0.009 GO:0006875 BP 1 cellular metal ion homeostasis 1 P19634,Q92633 274 1.05e-03 240 2 2 1.000 0.008 GO:0005543 MF 1 phospholipid binding 1 P19634,Q92633 274 1.20e-03 256 2 2 1.000 0.008 GO:0055065 BP 1 metal ion homeostasis 1 P19634,Q92633 274 1.27e-03 3 2 1 0.500 0.333 GO:0070886 BP 1 positive regulation of calcineurin-NFAT signaling cascade 1 P19634 274 1.27e-03 3 2 1 0.500 0.333 GO:1903279 BP 1 regulation of calcium:sodium antiporter activity 1 P19634 274 1.28e-03 265 2 2 1.000 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 P19634,Q92633 274 1.31e-03 406 2 2 1.000 0.005 MI:hsa-miR-544 mi 1 MI:hsa-miR-544 1 P19634,Q92633 274 1.48e-03 285 2 2 1.000 0.007 GO:0030003 BP 1 cellular cation homeostasis 1 P19634,Q92633 274 1.55e-03 291 2 2 1.000 0.007 GO:0006873 BP 1 cellular ion homeostasis 1 P19634,Q92633 274 1.69e-03 4 2 1 0.500 0.250 GO:0086036 BP 1 regulation of cardiac muscle cell membrane potential 1 P19634 274 1.69e-03 4 2 1 0.500 0.250 GO:0098735 BP 1 positive regulation of the force of heart contraction 1 P19634 274 1.77e-03 311 2 2 1.000 0.006 GO:0055080 BP 1 cation homeostasis 1 P19634,Q92633 274 1.86e-03 319 2 2 1.000 0.006 GO:0098771 BP 1 inorganic ion homeostasis 1 P19634,Q92633 274 2.09e-03 338 2 2 1.000 0.006 GO:0055082 BP 1 cellular chemical homeostasis 1 P19634,Q92633 274 2.11e-03 5 2 1 0.500 0.200 GO:0030346 MF 1 protein phosphatase 2B binding 1 P19634 274 2.11e-03 5 2 1 0.500 0.200 GO:0045125 MF 1 bioactive lipid receptor activity 1 Q92633 274 2.11e-03 5 2 1 0.500 0.200 GO:0035994 BP 1 response to muscle stretch 1 P19634 274 2.17e-03 345 2 2 1.000 0.006 GO:0008289 MF 1 lipid binding 1 P19634,Q92633 274 2.20e-03 347 2 2 1.000 0.006 GO:0050801 BP 1 ion homeostasis 1 P19634,Q92633 274 2.34e-03 358 2 2 1.000 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 P19634,Q92633 274 2.53e-03 6 2 1 0.500 0.167 GO:0010447 BP 1 response to acidic pH 1 P19634 274 2.53e-03 6 2 1 0.500 0.167 GO:0071468 BP 1 cellular response to acidic pH 1 P19634 274 2.71e-03 385 2 2 1.000 0.005 GO:0019725 BP 1 cellular homeostasis 1 P19634,Q92633 274 2.96e-03 7 2 1 0.500 0.143 GO:0071872 BP 1 cellular response to epinephrine stimulus 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:0015386 MF 1 potassium:proton antiporter activity 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:0098719 BP 1 sodium ion import across plasma membrane 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:0051533 BP 1 positive regulation of NFAT protein import into nucleus 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:1990118 BP 1 sodium ion import into cell 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:0071871 BP 1 response to epinephrine 1 P19634 274 2.96e-03 7 2 1 0.500 0.143 GO:0015385 MF 1 sodium:proton antiporter activity 1 P19634 274 3.02e-03 6 2 1 0.500 0.167 REAC:425986 rea 1 Sodium/Proton exchangers 1 P19634 274 3.21e-03 419 2 2 1.000 0.005 GO:0030029 BP 1 actin filament-based process 1 P19634,Q92633 274 3.38e-03 8 2 1 0.500 0.125 GO:0010613 BP 1 positive regulation of cardiac muscle hypertrophy 1 P19634 274 3.38e-03 8 2 1 0.500 0.125 GO:0014742 BP 1 positive regulation of muscle hypertrophy 1 P19634 274 3.38e-03 8 2 1 0.500 0.125 GO:0097369 BP 1 sodium ion import 1 P19634 274 3.38e-03 8 2 1 0.500 0.125 GO:0022821 MF 1 potassium ion antiporter activity 1 P19634 274 3.52e-03 7 2 1 0.500 0.143 REAC:419408 rea 1 Lysosphingolipid and LPA receptors 1 Q92633 274 3.80e-03 9 2 1 0.500 0.111 GO:0051532 BP 1 regulation of NFAT protein import into nucleus 1 P19634 274 3.80e-03 9 2 1 0.500 0.111 GO:0090533 CC 1 cation-transporting ATPase complex 1 P19634 274 3.80e-03 9 2 1 0.500 0.111 GO:0070884 BP 1 regulation of calcineurin-NFAT signaling cascade 1 P19634 274 3.80e-03 9 2 1 0.500 0.111 GO:0051531 BP 1 NFAT protein import into nucleus 1 P19634 274 3.80e-03 9 2 1 0.500 0.111 GO:2000651 BP 1 positive regulation of sodium ion transmembrane transporter activity 1 P19634 274 3.80e-03 9 2 1 0.500 0.111 GO:0005451 MF 1 monovalent cation:proton antiporter activity 1 P19634 274 4.22e-03 10 2 1 0.500 0.100 GO:0071467 BP 1 cellular response to pH 1 P19634 274 4.22e-03 10 2 1 0.500 0.100 GO:0009268 BP 1 response to pH 1 P19634 274 4.22e-03 10 2 1 0.500 0.100 GO:0051482 BP 1 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway 1 Q92633 274 4.22e-03 10 2 1 0.500 0.100 GO:0015299 MF 1 solute:proton antiporter activity 1 P19634 274 4.22e-03 10 2 1 0.500 0.100 GO:0071436 BP 1 sodium ion export 1 P19634 274 4.22e-03 10 2 1 0.500 0.100 GO:0030011 BP 1 maintenance of cell polarity 1 P19634 274 4.26e-03 483 2 2 1.000 0.004 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 P19634,Q92633 274 4.64e-03 504 2 2 1.000 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 P19634,Q92633 274 4.64e-03 11 2 1 0.500 0.091 GO:0030214 BP 1 hyaluronan catabolic process 1 P19634 274 4.79e-03 512 2 2 1.000 0.004 GO:0048878 BP 1 chemical homeostasis 1 P19634,Q92633 274 5.03e-03 10 2 1 0.500 0.100 REAC:2160916 rea 1 Hyaluronan uptake and degradation 1 P19634 274 5.07e-03 12 2 1 0.500 0.083 GO:0050850 BP 1 positive regulation of calcium-mediated signaling 1 P19634 274 5.07e-03 12 2 1 0.500 0.083 GO:0002026 BP 1 regulation of the force of heart contraction 1 P19634 274 5.07e-03 12 2 1 0.500 0.083 GO:1902307 BP 1 positive regulation of sodium ion transmembrane transport 1 P19634 274 5.49e-03 13 2 1 0.500 0.077 GO:1901021 BP 1 positive regulation of calcium ion transmembrane transporter activity 1 P19634 274 5.49e-03 13 2 1 0.500 0.077 GO:0098739 BP 1 import across plasma membrane 1 P19634 274 5.49e-03 13 2 1 0.500 0.077 GO:0035025 BP 1 positive regulation of Rho protein signal transduction 1 Q92633 274 5.91e-03 14 2 1 0.500 0.071 GO:0033173 BP 1 calcineurin-NFAT signaling cascade 1 P19634 274 5.91e-03 14 2 1 0.500 0.071 GO:0010611 BP 1 regulation of cardiac muscle hypertrophy 1 P19634 274 5.91e-03 14 2 1 0.500 0.071 GO:0014743 BP 1 regulation of muscle hypertrophy 1 P19634 274 5.91e-03 14 2 1 0.500 0.071 GO:0097720 BP 1 calcineurin-mediated signaling 1 P19634 274 6.04e-03 12 2 1 0.500 0.083 REAC:2142845 rea 1 Hyaluronan metabolism 1 P19634 274 6.33e-03 15 2 1 0.500 0.067 GO:0098659 BP 1 inorganic cation import into cell 1 P19634 274 6.33e-03 15 2 1 0.500 0.067 GO:0007202 BP 1 activation of phospholipase C activity 1 Q92633 274 6.33e-03 15 2 1 0.500 0.067 GO:0099587 BP 1 inorganic ion import into cell 1 P19634 274 6.33e-03 15 2 1 0.500 0.067 GO:0010882 BP 1 regulation of cardiac muscle contraction by calcium ion signaling 1 P19634 274 6.75e-03 16 2 1 0.500 0.062 GO:1904949 CC 1 ATPase complex 1 P19634 274 6.75e-03 16 2 1 0.500 0.062 GO:0098533 CC 1 ATPase dependent transmembrane transport complex 1 P19634 274 6.75e-03 16 2 1 0.500 0.062 GO:0006883 BP 1 cellular sodium ion homeostasis 1 P19634 274 6.75e-03 16 2 1 0.500 0.062 GO:0015491 MF 1 cation:cation antiporter activity 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0030212 BP 1 hyaluronan metabolic process 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0071868 BP 1 cellular response to monoamine stimulus 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0071867 BP 1 response to monoamine 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0015298 MF 1 solute:cation antiporter activity 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0071870 BP 1 cellular response to catecholamine stimulus 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0048016 BP 1 inositol phosphate-mediated signaling 1 P19634 274 7.17e-03 17 2 1 0.500 0.059 GO:0071869 BP 1 response to catecholamine 1 P19634 274 7.49e-03 640 2 2 1.000 0.003 GO:0016477 BP 1 cell migration 1 P19634,Q92633 274 8.44e-03 20 2 1 0.500 0.050 GO:0010765 BP 1 positive regulation of sodium ion transport 1 P19634 274 8.86e-03 21 2 1 0.500 0.048 GO:0010863 BP 1 positive regulation of phospholipase C activity 1 Q92633 274 8.86e-03 21 2 1 0.500 0.048 GO:1904427 BP 1 positive regulation of calcium ion transmembrane transport 1 P19634 274 8.86e-03 21 2 1 0.500 0.048 GO:0003300 BP 1 cardiac muscle hypertrophy 1 P19634 274 8.86e-03 21 2 1 0.500 0.048 GO:0014897 BP 1 striated muscle hypertrophy 1 P19634 274 9.14e-03 707 2 2 1.000 0.003 GO:0033043 BP 1 regulation of organelle organization 1 P19634,Q92633 274 9.24e-03 711 2 2 1.000 0.003 GO:0051674 BP 1 localization of cell 1 P19634,Q92633 274 9.24e-03 711 2 2 1.000 0.003 GO:0048870 BP 1 cell motility 1 P19634,Q92633 274 9.28e-03 22 2 1 0.500 0.045 GO:0014896 BP 1 muscle hypertrophy 1 P19634 274 9.28e-03 22 2 1 0.500 0.045 GO:0046579 BP 1 positive regulation of Ras protein signal transduction 1 Q92633 274 9.28e-03 22 2 1 0.500 0.045 GO:0043502 BP 1 regulation of muscle adaptation 1 P19634 274 9.28e-03 22 2 1 0.500 0.045 GO:0051496 BP 1 positive regulation of stress fiber assembly 1 Q92633 274 9.70e-03 23 2 1 0.500 0.043 GO:2000649 BP 1 regulation of sodium ion transmembrane transporter activity 1 P19634 274 9.70e-03 23 2 1 0.500 0.043 GO:0055078 BP 1 sodium ion homeostasis 1 P19634 274 9.70e-03 23 2 1 0.500 0.043 GO:0051057 BP 1 positive regulation of small GTPase mediated signal transduction 1 Q92633 274 1.01e-02 24 2 1 0.500 0.042 GO:1900274 BP 1 regulation of phospholipase C activity 1 Q92633 274 1.05e-02 758 2 2 1.000 0.003 GO:0007010 BP 1 cytoskeleton organization 1 P19634,Q92633 274 1.06e-02 763 2 2 1.000 0.003 GO:0009967 BP 1 positive regulation of signal transduction 1 P19634,Q92633 274 1.12e-02 783 2 2 1.000 0.003 GO:0042592 BP 1 homeostatic process 1 P19634,Q92633 274 1.14e-02 27 2 1 0.500 0.037 GO:0032233 BP 1 positive regulation of actin filament bundle assembly 1 Q92633 274 1.16e-02 798 2 2 1.000 0.003 GO:0010647 BP 1 positive regulation of cell communication 1 P19634,Q92633 274 1.18e-02 28 2 1 0.500 0.036 GO:0099516 MF 1 ion antiporter activity 1 P19634 274 1.18e-02 28 2 1 0.500 0.036 GO:0010518 BP 1 positive regulation of phospholipase activity 1 Q92633 274 1.18e-02 28 2 1 0.500 0.036 GO:0042993 BP 1 positive regulation of transcription factor import into nucleus 1 P19634 274 1.18e-02 28 2 1 0.500 0.036 GO:0071260 BP 1 cellular response to mechanical stimulus 1 P19634 274 1.18e-02 28 2 1 0.500 0.036 GO:0043500 BP 1 muscle adaptation 1 P19634 274 1.18e-02 804 2 2 1.000 0.002 GO:0023056 BP 1 positive regulation of signaling 1 P19634,Q92633 274 1.19e-02 808 2 2 1.000 0.002 GO:0005887 CC 1 integral component of plasma membrane 1 P19634,Q92633 274 1.21e-02 814 2 2 1.000 0.002 GO:0040011 BP 1 locomotion 1 P19634,Q92633 274 1.25e-02 826 2 2 1.000 0.002 GO:0043168 MF 1 anion binding 1 P19634,Q92633 274 1.27e-02 835 2 2 1.000 0.002 GO:0009605 BP 1 response to external stimulus 1 P19634,Q92633 274 1.30e-02 843 2 2 1.000 0.002 GO:0031226 CC 1 intrinsic component of plasma membrane 1 P19634,Q92633 274 1.32e-02 850 2 2 1.000 0.002 GO:0044093 BP 1 positive regulation of molecular function 1 P19634,Q92633 274 1.35e-02 32 2 1 0.500 0.031 GO:1902305 BP 1 regulation of sodium ion transmembrane transport 1 P19634 274 1.39e-02 33 2 1 0.500 0.030 GO:0051893 BP 1 regulation of focal adhesion assembly 1 P19634 274 1.39e-02 33 2 1 0.500 0.030 GO:0090109 BP 1 regulation of cell-substrate junction assembly 1 P19634 274 1.39e-02 33 2 1 0.500 0.030 GO:0035023 BP 1 regulation of Rho protein signal transduction 1 Q92633 274 1.39e-02 33 2 1 0.500 0.030 GO:1902600 BP 1 hydrogen ion transmembrane transport 1 P19634 274 1.43e-02 34 2 1 0.500 0.029 GO:0060193 BP 1 positive regulation of lipase activity 1 Q92633 274 1.48e-02 35 2 1 0.500 0.029 GO:0007193 BP 1 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 1 Q92633 274 1.48e-02 35 2 1 0.500 0.029 GO:0010517 BP 1 regulation of phospholipase activity 1 Q92633 274 1.48e-02 35 2 1 0.500 0.029 GO:0032414 BP 1 positive regulation of ion transmembrane transporter activity 1 P19634 274 1.48e-02 35 2 1 0.500 0.029 GO:1903391 BP 1 regulation of adherens junction organization 1 P19634 274 1.48e-02 35 2 1 0.500 0.029 GO:0055117 BP 1 regulation of cardiac muscle contraction 1 P19634 274 1.52e-02 36 2 1 0.500 0.028 GO:0007200 BP 1 phospholipase C-activating G-protein coupled receptor signaling pathway 1 Q92633 274 1.52e-02 36 2 1 0.500 0.028 GO:0051928 BP 1 positive regulation of calcium ion transport 1 P19634 274 1.56e-02 37 2 1 0.500 0.027 GO:0050848 BP 1 regulation of calcium-mediated signaling 1 P19634 274 1.60e-02 38 2 1 0.500 0.026 GO:0048306 MF 1 calcium-dependent protein binding 1 P19634 274 1.64e-02 39 2 1 0.500 0.026 GO:1901019 BP 1 regulation of calcium ion transmembrane transporter activity 1 P19634 274 1.64e-02 39 2 1 0.500 0.026 GO:0098657 BP 1 import into cell 1 P19634 274 1.64e-02 39 2 1 0.500 0.026 GO:0015297 MF 1 antiporter activity 1 P19634 274 1.69e-02 40 2 1 0.500 0.025 GO:1904064 BP 1 positive regulation of cation transmembrane transport 1 P19634 274 1.73e-02 41 2 1 0.500 0.024 GO:0005546 MF 1 phosphatidylinositol-4,5-bisphosphate binding 1 P19634 274 1.73e-02 41 2 1 0.500 0.024 GO:0032411 BP 1 positive regulation of transporter activity 1 P19634 274 1.81e-02 43 2 1 0.500 0.023 GO:0006027 BP 1 glycosaminoglycan catabolic process 1 P19634 274 1.85e-02 44 2 1 0.500 0.023 GO:0060191 BP 1 regulation of lipase activity 1 Q92633 274 1.89e-02 1016 2 2 1.000 0.002 GO:0006928 BP 1 movement of cell or subcellular component 1 P19634,Q92633 274 1.93e-02 1027 2 2 1.000 0.002 GO:1902531 BP 1 regulation of intracellular signal transduction 1 P19634,Q92633 274 1.94e-02 46 2 1 0.500 0.022 GO:0006942 BP 1 regulation of striated muscle contraction 1 P19634 274 1.94e-02 46 2 1 0.500 0.022 GO:0002028 BP 1 regulation of sodium ion transport 1 P19634 274 1.98e-02 47 2 1 0.500 0.021 GO:0048041 BP 1 focal adhesion assembly 1 P19634 274 1.98e-02 47 2 1 0.500 0.021 GO:0034767 BP 1 positive regulation of ion transmembrane transport 1 P19634 274 1.98e-02 47 2 1 0.500 0.021 GO:0007045 BP 1 cell-substrate adherens junction assembly 1 P19634 274 2.02e-02 48 2 1 0.500 0.021 GO:1901888 BP 1 regulation of cell junction assembly 1 P19634 274 2.07e-02 49 2 1 0.500 0.020 GO:0006026 BP 1 aminoglycan catabolic process 1 P19634 274 2.11e-02 50 2 1 0.500 0.020 GO:0032947 MF 1 protein complex scaffold 1 P19634 274 2.15e-02 29 2 1 0.500 0.034 HP:0002070 hp 1 Limb ataxia 1 P19634 274 2.15e-02 51 2 1 0.500 0.020 GO:0001952 BP 1 regulation of cell-matrix adhesion 1 P19634 274 2.15e-02 51 2 1 0.500 0.020 GO:0042307 BP 1 positive regulation of protein import into nucleus 1 P19634 274 2.16e-02 1086 2 2 1.000 0.002 GO:0048584 BP 1 positive regulation of response to stimulus 1 P19634,Q92633 274 2.19e-02 52 2 1 0.500 0.019 GO:0042990 BP 1 regulation of transcription factor import into nucleus 1 P19634 274 2.19e-02 52 2 1 0.500 0.019 GO:1904591 BP 1 positive regulation of protein import 1 P19634 274 2.19e-02 52 2 1 0.500 0.019 GO:0034333 BP 1 adherens junction assembly 1 P19634 274 2.19e-02 52 2 1 0.500 0.019 GO:1903169 BP 1 regulation of calcium ion transmembrane transport 1 P19634 274 2.19e-02 52 2 1 0.500 0.019 GO:0034764 BP 1 positive regulation of transmembrane transport 1 P19634 274 2.19e-02 51 2 1 0.500 0.020 KEGG:04976 keg 1 Bile secretion 1 P19634 274 2.23e-02 53 2 1 0.500 0.019 GO:0015992 BP 1 proton transport 1 P19634 274 2.23e-02 53 2 1 0.500 0.019 GO:0009612 BP 1 response to mechanical stimulus 1 P19634 274 2.23e-02 53 2 1 0.500 0.019 GO:0015078 MF 1 hydrogen ion transmembrane transporter activity 1 P19634 274 2.32e-02 55 2 1 0.500 0.018 GO:0006818 BP 1 hydrogen transport 1 P19634 274 2.32e-02 55 2 1 0.500 0.018 GO:0042991 BP 1 transcription factor import into nucleus 1 P19634 274 2.40e-02 57 2 1 0.500 0.018 GO:0060048 BP 1 cardiac muscle contraction 1 P19634 274 2.40e-02 57 2 1 0.500 0.018 GO:0051453 BP 1 regulation of intracellular pH 1 P19634 274 2.40e-02 57 2 1 0.500 0.018 GO:0007044 BP 1 cell-substrate junction assembly 1 P19634 274 2.44e-02 58 2 1 0.500 0.017 GO:0010977 BP 1 negative regulation of neuron projection development 1 Q92633 274 2.44e-02 58 2 1 0.500 0.017 GO:0030641 BP 1 regulation of cellular pH 1 P19634 274 2.49e-02 59 2 1 0.500 0.017 GO:1902936 MF 1 phosphatidylinositol bisphosphate binding 1 P19634 274 2.49e-02 58 2 1 0.500 0.017 KEGG:04971 keg 1 Gastric acid secretion 1 P19634 274 2.50e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 P19634,Q92633 274 2.57e-02 61 2 1 0.500 0.016 GO:0006885 BP 1 regulation of pH 1 P19634 274 2.61e-02 62 2 1 0.500 0.016 GO:0035725 BP 1 sodium ion transmembrane transport 1 P19634 274 2.62e-02 61 2 1 0.500 0.016 KEGG:04260 keg 1 Cardiac muscle contraction 1 P19634 274 2.70e-02 64 2 1 0.500 0.016 GO:0007266 BP 1 Rho protein signal transduction 1 Q92633 274 2.74e-02 65 2 1 0.500 0.015 GO:0046824 BP 1 positive regulation of nucleocytoplasmic transport 1 P19634 274 2.75e-02 64 2 1 0.500 0.016 KEGG:04970 keg 1 Salivary secretion 1 P19634 274 2.86e-02 68 2 1 0.500 0.015 GO:0006937 BP 1 regulation of muscle contraction 1 P19634 274 2.86e-02 68 2 1 0.500 0.015 GO:1903510 BP 1 mucopolysaccharide metabolic process 1 P19634 274 2.86e-02 68 2 1 0.500 0.015 GO:0046578 BP 1 regulation of Ras protein signal transduction 1 Q92633 274 2.92e-02 1263 2 2 1.000 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 P19634,Q92633 274 2.92e-02 68 2 1 0.500 0.015 KEGG:04972 keg 1 Pancreatic secretion 1 P19634 274 2.96e-02 1272 2 2 1.000 0.002 GO:0044459 CC 1 plasma membrane part 1 P19634,Q92633 274 2.99e-02 71 2 1 0.500 0.014 GO:0019903 MF 1 protein phosphatase binding 1 P19634 274 3.03e-02 72 2 1 0.500 0.014 GO:0045665 BP 1 negative regulation of neuron differentiation 1 Q92633 274 3.03e-02 72 2 1 0.500 0.014 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 P19634 274 3.05e-02 1291 2 2 1.000 0.002 GO:0043167 MF 1 ion binding 1 P19634,Q92633 274 3.07e-02 73 2 1 0.500 0.014 GO:0007188 BP 1 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 1 Q92633 274 3.07e-02 73 2 1 0.500 0.014 GO:0030004 BP 1 cellular monovalent inorganic cation homeostasis 1 P19634 274 3.07e-02 73 2 1 0.500 0.014 GO:0071804 BP 1 cellular potassium ion transport 1 P19634 274 3.07e-02 73 2 1 0.500 0.014 GO:0071805 BP 1 potassium ion transmembrane transport 1 P19634 274 3.07e-02 73 2 1 0.500 0.014 GO:0034332 BP 1 adherens junction organization 1 P19634 274 3.10e-02 42 2 1 0.500 0.024 HP:0002075 hp 1 Dysdiadochokinesis 1 P19634 274 3.12e-02 74 2 1 0.500 0.014 GO:0031345 BP 1 negative regulation of cell projection organization 1 Q92633 274 3.16e-02 75 2 1 0.500 0.013 GO:0006941 BP 1 striated muscle contraction 1 P19634 274 3.24e-02 77 2 1 0.500 0.013 GO:0007187 BP 1 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1 Q92633 274 3.24e-02 77 2 1 0.500 0.013 GO:0019722 BP 1 calcium-mediated signaling 1 P19634 274 3.26e-02 65 2 1 0.500 0.015 REAC:425393 rea 1 Transport of inorganic cations/anions and amino acids/oligopeptides 1 P19634 274 3.41e-02 81 2 1 0.500 0.012 GO:0051924 BP 1 regulation of calcium ion transport 1 P19634 274 3.47e-02 81 2 1 0.500 0.012 KEGG:04540 keg 1 Gap junction 1 Q92633 274 3.52e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 P19634,Q92633 274 3.53e-02 84 2 1 0.500 0.012 GO:0055067 BP 1 monovalent inorganic cation homeostasis 1 P19634 274 3.54e-02 1392 2 2 1.000 0.001 GO:0016021 CC 1 integral component of membrane 1 P19634,Q92633 274 3.58e-02 85 2 1 0.500 0.012 GO:0090257 BP 1 regulation of muscle system process 1 P19634 274 3.58e-02 85 2 1 0.500 0.012 GO:0008360 BP 1 regulation of cell shape 1 Q92633 274 3.66e-02 87 2 1 0.500 0.011 GO:0015079 MF 1 potassium ion transmembrane transporter activity 1 P19634 274 3.66e-02 87 2 1 0.500 0.011 GO:0015081 MF 1 sodium ion transmembrane transporter activity 1 P19634 274 3.66e-02 87 2 1 0.500 0.011 GO:0050768 BP 1 negative regulation of neurogenesis 1 Q92633 274 3.70e-02 88 2 1 0.500 0.011 GO:0061337 BP 1 cardiac conduction 1 P19634 274 3.70e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 P19634,Q92633 274 3.74e-02 89 2 1 0.500 0.011 GO:0006814 BP 1 sodium ion transport 1 P19634 274 3.74e-02 89 2 1 0.500 0.011 GO:0043270 BP 1 positive regulation of ion transport 1 P19634 274 3.78e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 P19634,Q92633 274 3.79e-02 90 2 1 0.500 0.011 GO:0030027 CC 1 lamellipodium 1 P19634 274 3.79e-02 90 2 1 0.500 0.011 GO:0010810 BP 1 regulation of cell-substrate adhesion 1 P19634 274 3.79e-02 1440 2 2 1.000 0.001 GO:0031224 CC 1 intrinsic component of membrane 1 P19634,Q92633 274 3.86e-02 77 2 1 0.500 0.013 REAC:373076 rea 1 Class A/1 (Rhodopsin-like receptors) 1 Q92633 274 3.91e-02 93 2 1 0.500 0.011 GO:1901981 MF 1 phosphatidylinositol phosphate binding 1 P19634 274 3.95e-02 94 2 1 0.500 0.011 GO:0051961 BP 1 negative regulation of nervous system development 1 Q92633 274 3.95e-02 94 2 1 0.500 0.011 GO:0042306 BP 1 regulation of protein import into nucleus 1 P19634 274 4.04e-02 96 2 1 0.500 0.010 GO:0006813 BP 1 potassium ion transport 1 P19634 274 4.04e-02 96 2 1 0.500 0.010 GO:1904589 BP 1 regulation of protein import 1 P19634 274 4.08e-02 97 2 1 0.500 0.010 GO:0007204 BP 1 positive regulation of cytosolic calcium ion concentration 1 Q92633 274 4.25e-02 101 2 1 0.500 0.010 GO:0060326 BP 1 cell chemotaxis 1 Q92633 274 4.25e-02 101 2 1 0.500 0.010 GO:0010721 BP 1 negative regulation of cell development 1 Q92633 274 4.25e-02 101 2 1 0.500 0.010 GO:0019902 MF 1 phosphatase binding 1 P19634 274 4.25e-02 101 2 1 0.500 0.010 GO:0015291 MF 1 secondary active transmembrane transporter activity 1 P19634 274 4.29e-02 102 2 1 0.500 0.010 GO:0007163 BP 1 establishment or maintenance of cell polarity 1 P19634 274 4.30e-02 1533 2 2 1.000 0.001 GO:0035556 BP 1 intracellular signal transduction 1 P19634,Q92633 274 4.37e-02 104 2 1 0.500 0.010 GO:0032412 BP 1 regulation of ion transmembrane transporter activity 1 P19634 274 4.40e-02 88 2 1 0.500 0.011 REAC:416476 rea 1 G alpha (q) signalling events 1 Q92633 274 4.41e-02 105 2 1 0.500 0.010 GO:0030203 BP 1 glycosaminoglycan metabolic process 1 P19634 274 4.41e-02 105 2 1 0.500 0.010 GO:0022898 BP 1 regulation of transmembrane transporter activity 1 P19634 274 4.46e-02 106 2 1 0.500 0.009 GO:0030674 MF 1 protein binding, bridging 1 P19634 274 4.49e-02 105 2 1 0.500 0.010 KEGG:04919 keg 1 Thyroid hormone signaling pathway 1 P19634 274 4.50e-02 107 2 1 0.500 0.009 GO:0035637 BP 1 multicellular organismal signaling 1 P19634 274 4.53e-02 1573 2 2 1.000 0.001 GO:0009966 BP 1 regulation of signal transduction 1 P19634,Q92633 274 4.58e-02 107 2 1 0.500 0.009 KEGG:04080 keg 1 Neuroactive ligand-receptor interaction 1 Q92633 274 4.62e-02 110 2 1 0.500 0.009 GO:0070588 BP 1 calcium ion transmembrane transport 1 P19634 274 4.62e-02 110 2 1 0.500 0.009 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 Q92633 274 4.67e-02 111 2 1 0.500 0.009 GO:0051480 BP 1 regulation of cytosolic calcium ion concentration 1 Q92633 274 4.67e-02 111 2 1 0.500 0.009 GO:0006022 BP 1 aminoglycan metabolic process 1 P19634 274 4.75e-02 113 2 1 0.500 0.009 GO:1904062 BP 1 regulation of cation transmembrane transport 1 P19634 274 4.75e-02 113 2 1 0.500 0.009 GO:0007160 BP 1 cell-matrix adhesion 1 P19634 274 4.78e-02 271 2 1 0.500 0.004 MI:hsa-miR-526b* mi 1 MI:hsa-miR-526b* 1 P19634 274 4.85e-02 97 2 1 0.500 0.010 REAC:418594 rea 1 G alpha (i) signalling events 1 Q92633 274 4.87e-02 116 2 1 0.500 0.009 GO:0008016 BP 1 regulation of heart contraction 1 P19634 274 4.87e-02 116 2 1 0.500 0.009 GO:0032409 BP 1 regulation of transporter activity 1 P19634 274 4.89e-02 1635 2 2 1.000 0.001 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 P19634,Q92633 274 4.95e-02 1644 2 2 1.000 0.001 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 P19634,Q92633 274 5.00e-02 119 2 1 0.500 0.008 GO:0071496 BP 1 cellular response to external stimulus 1 P19634 274 5.00e-02 419 2 2 1.000 0.005 TF:M01801_0 tf 1 Factor: ER-alpha; motif: AGGTCACNGTGACCT; match class: 0 1 P19634,Q92633 274 5.00e-02 117 2 1 0.500 0.009 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 Q92633 274 5.00e-02 100 2 1 0.500 0.010 REAC:1630316 rea 1 Glycosaminoglycan metabolism 1 P19634 274 5.00e-02 1 2 1 0.500 1.000 OMIM:616291 omi 1 LICHTENSTEIN-KNORR SYNDROME; LIKNS;;SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 19; SCAR19 1 P19634 274 5.00e-02 119 2 1 0.500 0.008 GO:1900180 BP 1 regulation of protein localization to nucleus 1 P19634 275 4.00e-02 12 2 1 0.500 0.083 GO:0046827 BP 1 positive regulation of protein export from nucleus 1 Q9H6Z4 275 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q9H6Z4 275 5.00e-02 158 2 2 1.000 0.013 TF:M06398_0 tf 1 Factor: ZNF761; motif: GGKWAATCAGA; match class: 0 1 Q9H6Z4,Q9UGI8 276 5.42e-08 3 2 2 1.000 0.667 GO:1903690 BP 1 negative regulation of wound healing, spreading of epidermal cells 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:0045180 CC 1 basal cortex 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:1904259 BP 1 regulation of basement membrane assembly involved in embryonic body morphogenesis 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:1903689 BP 1 regulation of wound healing, spreading of epidermal cells 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:1904261 BP 1 positive regulation of basement membrane assembly involved in embryonic body morphogenesis 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:0070831 BP 1 basement membrane assembly 1 Q7Z460,O75122 276 1.81e-07 5 2 2 1.000 0.400 GO:2001197 BP 1 basement membrane assembly involved in embryonic body morphogenesis 1 Q7Z460,O75122 276 2.71e-07 6 2 2 1.000 0.333 GO:0005828 CC 1 kinetochore microtubule 1 Q7Z460,O75122 276 2.71e-07 6 2 2 1.000 0.333 GO:0002162 MF 1 dystroglycan binding 1 Q7Z460,O75122 276 2.71e-07 6 2 2 1.000 0.333 GO:0090091 BP 1 positive regulation of extracellular matrix disassembly 1 Q7Z460,O75122 276 5.06e-07 8 2 2 1.000 0.250 GO:1905331 BP 1 negative regulation of morphogenesis of an epithelium 1 Q7Z460,O75122 276 5.06e-07 8 2 2 1.000 0.250 GO:0071711 BP 1 basement membrane organization 1 Q7Z460,O75122 276 5.06e-07 8 2 2 1.000 0.250 GO:0010172 BP 1 embryonic body morphogenesis 1 Q7Z460,O75122 276 5.06e-07 8 2 2 1.000 0.250 GO:1901203 BP 1 positive regulation of extracellular matrix assembly 1 Q7Z460,O75122 276 6.50e-07 9 2 2 1.000 0.222 GO:0035313 BP 1 wound healing, spreading of epidermal cells 1 Q7Z460,O75122 276 6.50e-07 9 2 2 1.000 0.222 GO:0051010 MF 1 microtubule plus-end binding 1 Q7Z460,O75122 276 6.50e-07 9 2 2 1.000 0.222 GO:0099738 CC 1 cell cortex region 1 Q7Z460,O75122 276 6.50e-07 9 2 2 1.000 0.222 GO:1901201 BP 1 regulation of extracellular matrix assembly 1 Q7Z460,O75122 276 8.13e-07 10 2 2 1.000 0.200 GO:0051497 BP 1 negative regulation of stress fiber assembly 1 Q7Z460,O75122 276 9.94e-07 11 2 2 1.000 0.182 GO:0007026 BP 1 negative regulation of microtubule depolymerization 1 Q7Z460,O75122 276 9.94e-07 11 2 2 1.000 0.182 GO:0031114 BP 1 regulation of microtubule depolymerization 1 Q7Z460,O75122 276 1.19e-06 12 2 2 1.000 0.167 GO:0032232 BP 1 negative regulation of actin filament bundle assembly 1 Q7Z460,O75122 276 1.41e-06 13 2 2 1.000 0.154 GO:0010715 BP 1 regulation of extracellular matrix disassembly 1 Q7Z460,O75122 276 1.41e-06 13 2 2 1.000 0.154 GO:1903055 BP 1 positive regulation of extracellular matrix organization 1 Q7Z460,O75122 276 1.46e-06 9 2 2 1.000 0.222 REAC:428890 rea 1 Role of Abl in Robo-Slit signaling 1 Q7Z460,O75122 276 1.64e-06 14 2 2 1.000 0.143 GO:0034453 BP 1 microtubule anchoring 1 Q7Z460,O75122 276 1.90e-06 15 2 2 1.000 0.133 GO:0045178 CC 1 basal part of cell 1 Q7Z460,O75122 276 2.17e-06 16 2 2 1.000 0.125 GO:0040019 BP 1 positive regulation of embryonic development 1 Q7Z460,O75122 276 2.17e-06 16 2 2 1.000 0.125 GO:0031111 BP 1 negative regulation of microtubule polymerization or depolymerization 1 Q7Z460,O75122 276 2.46e-06 17 2 2 1.000 0.118 GO:0085029 BP 1 extracellular matrix assembly 1 Q7Z460,O75122 276 3.09e-06 19 2 2 1.000 0.105 GO:0044319 BP 1 wound healing, spreading of cells 1 Q7Z460,O75122 276 3.09e-06 19 2 2 1.000 0.105 GO:0090505 BP 1 epiboly involved in wound healing 1 Q7Z460,O75122 276 3.09e-06 19 2 2 1.000 0.105 GO:0007020 BP 1 microtubule nucleation 1 Q7Z460,O75122 276 3.43e-06 20 2 2 1.000 0.100 GO:0090504 BP 1 epiboly 1 Q7Z460,O75122 276 3.43e-06 20 2 2 1.000 0.100 GO:0010470 BP 1 regulation of gastrulation 1 Q7Z460,O75122 276 3.79e-06 21 2 2 1.000 0.095 GO:0010171 BP 1 body morphogenesis 1 Q7Z460,O75122 276 4.17e-06 22 2 2 1.000 0.091 GO:0007019 BP 1 microtubule depolymerization 1 Q7Z460,O75122 276 4.57e-06 23 2 2 1.000 0.087 GO:1903053 BP 1 regulation of extracellular matrix organization 1 Q7Z460,O75122 276 4.99e-06 24 2 2 1.000 0.083 GO:0010458 BP 1 exit from mitosis 1 Q7Z460,O75122 276 6.34e-06 27 2 2 1.000 0.074 GO:1901880 BP 1 negative regulation of protein depolymerization 1 Q7Z460,O75122 276 7.34e-06 29 2 2 1.000 0.069 GO:0043242 BP 1 negative regulation of protein complex disassembly 1 Q7Z460,O75122 276 7.86e-06 30 2 2 1.000 0.067 GO:0031110 BP 1 regulation of microtubule polymerization or depolymerization 1 Q7Z460,O75122 276 7.86e-06 30 2 2 1.000 0.067 GO:0002011 BP 1 morphogenesis of an epithelial sheet 1 Q7Z460,O75122 276 9.54e-06 33 2 2 1.000 0.061 GO:0051893 BP 1 regulation of focal adhesion assembly 1 Q7Z460,O75122 276 9.54e-06 33 2 2 1.000 0.061 GO:0090109 BP 1 regulation of cell-substrate junction assembly 1 Q7Z460,O75122 276 1.01e-05 34 2 2 1.000 0.059 GO:1901879 BP 1 regulation of protein depolymerization 1 Q7Z460,O75122 276 1.08e-05 35 2 2 1.000 0.057 GO:1903391 BP 1 regulation of adherens junction organization 1 Q7Z460,O75122 276 1.08e-05 35 2 2 1.000 0.057 GO:0005881 CC 1 cytoplasmic microtubule 1 Q7Z460,O75122 276 1.20e-05 37 2 2 1.000 0.054 GO:0061045 BP 1 negative regulation of wound healing 1 Q7Z460,O75122 276 1.20e-05 37 2 2 1.000 0.054 GO:0046785 BP 1 microtubule polymerization 1 Q7Z460,O75122 276 1.20e-05 37 2 2 1.000 0.054 GO:0051492 BP 1 regulation of stress fiber assembly 1 Q7Z460,O75122 276 1.48e-05 41 2 2 1.000 0.049 GO:1903035 BP 1 negative regulation of response to wounding 1 Q7Z460,O75122 276 1.56e-05 42 2 2 1.000 0.048 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 Q7Z460,O75122 276 1.71e-05 44 2 2 1.000 0.045 GO:0032231 BP 1 regulation of actin filament bundle assembly 1 Q7Z460,O75122 276 1.79e-05 45 2 2 1.000 0.044 GO:0043244 BP 1 regulation of protein complex disassembly 1 Q7Z460,O75122 276 1.88e-05 31 2 2 1.000 0.065 REAC:376176 rea 1 Signaling by Robo receptor 1 Q7Z460,O75122 276 1.95e-05 47 2 2 1.000 0.043 GO:0007045 BP 1 cell-substrate adherens junction assembly 1 Q7Z460,O75122 276 1.95e-05 47 2 2 1.000 0.043 GO:0048041 BP 1 focal adhesion assembly 1 Q7Z460,O75122 276 2.04e-05 48 2 2 1.000 0.042 GO:0005876 CC 1 spindle microtubule 1 Q7Z460,O75122 276 2.04e-05 48 2 2 1.000 0.042 GO:0043149 BP 1 stress fiber assembly 1 Q7Z460,O75122 276 2.04e-05 48 2 2 1.000 0.042 GO:0030038 BP 1 contractile actin filament bundle assembly 1 Q7Z460,O75122 276 2.04e-05 48 2 2 1.000 0.042 GO:0045921 BP 1 positive regulation of exocytosis 1 Q7Z460,O75122 276 2.04e-05 48 2 2 1.000 0.042 GO:1901888 BP 1 regulation of cell junction assembly 1 Q7Z460,O75122 276 2.12e-05 49 2 2 1.000 0.041 GO:0045995 BP 1 regulation of embryonic development 1 Q7Z460,O75122 276 2.30e-05 51 2 2 1.000 0.039 GO:0001952 BP 1 regulation of cell-matrix adhesion 1 Q7Z460,O75122 276 2.30e-05 51 2 2 1.000 0.039 GO:0010717 BP 1 regulation of epithelial to mesenchymal transition 1 Q7Z460,O75122 276 2.40e-05 52 2 2 1.000 0.038 GO:0034333 BP 1 adherens junction assembly 1 Q7Z460,O75122 276 2.59e-05 54 2 2 1.000 0.037 GO:0051261 BP 1 protein depolymerization 1 Q7Z460,O75122 276 2.88e-05 57 2 2 1.000 0.035 GO:0007044 BP 1 cell-substrate junction assembly 1 Q7Z460,O75122 276 2.99e-05 58 2 2 1.000 0.034 GO:0031109 BP 1 microtubule polymerization or depolymerization 1 Q7Z460,O75122 276 3.31e-05 61 2 2 1.000 0.033 GO:0001948 MF 1 glycoprotein binding 1 Q7Z460,O75122 276 4.00e-05 67 2 2 1.000 0.030 GO:0010634 BP 1 positive regulation of epithelial cell migration 1 Q7Z460,O75122 276 4.00e-05 67 2 2 1.000 0.030 GO:0006903 BP 1 vesicle targeting 1 Q7Z460,O75122 276 4.12e-05 68 2 2 1.000 0.029 GO:0051494 BP 1 negative regulation of cytoskeleton organization 1 Q7Z460,O75122 276 4.36e-05 70 2 2 1.000 0.029 GO:0044448 CC 1 cell cortex part 1 Q7Z460,O75122 276 4.49e-05 71 2 2 1.000 0.028 GO:0022617 BP 1 extracellular matrix disassembly 1 Q7Z460,O75122 276 4.49e-05 71 2 2 1.000 0.028 GO:0007369 BP 1 gastrulation 1 Q7Z460,O75122 276 4.75e-05 73 2 2 1.000 0.027 GO:0034332 BP 1 adherens junction organization 1 Q7Z460,O75122 276 4.88e-05 74 2 2 1.000 0.027 GO:0001837 BP 1 epithelial to mesenchymal transition 1 Q7Z460,O75122 276 5.57e-05 79 2 2 1.000 0.025 GO:0061041 BP 1 regulation of wound healing 1 Q7Z460,O75122 276 6.15e-05 83 2 2 1.000 0.024 GO:0051017 BP 1 actin filament bundle assembly 1 Q7Z460,O75122 276 6.30e-05 84 2 2 1.000 0.024 GO:0070507 BP 1 regulation of microtubule cytoskeleton organization 1 Q7Z460,O75122 276 6.30e-05 84 2 2 1.000 0.024 GO:0061572 BP 1 actin filament bundle organization 1 Q7Z460,O75122 276 6.45e-05 85 2 2 1.000 0.024 GO:1903034 BP 1 regulation of response to wounding 1 Q7Z460,O75122 276 6.76e-05 87 2 2 1.000 0.023 GO:0007030 BP 1 Golgi organization 1 Q7Z460,O75122 276 6.92e-05 88 2 2 1.000 0.023 GO:0007052 BP 1 mitotic spindle organization 1 Q7Z460,O75122 276 7.24e-05 90 2 2 1.000 0.022 GO:0010810 BP 1 regulation of cell-substrate adhesion 1 Q7Z460,O75122 276 7.40e-05 91 2 2 1.000 0.022 GO:0000776 CC 1 kinetochore 1 Q7Z460,O75122 276 7.56e-05 92 2 2 1.000 0.022 GO:0031032 BP 1 actomyosin structure organization 1 Q7Z460,O75122 276 9.12e-05 101 2 2 1.000 0.020 GO:0017157 BP 1 regulation of exocytosis 1 Q7Z460,O75122 276 9.31e-05 102 2 2 1.000 0.020 GO:0007163 BP 1 establishment or maintenance of cell polarity 1 Q7Z460,O75122 276 9.68e-05 104 2 2 1.000 0.019 GO:0032886 BP 1 regulation of microtubule-based process 1 Q7Z460,O75122 276 1.01e-04 106 2 2 1.000 0.019 GO:0031023 BP 1 microtubule organizing center organization 1 Q7Z460,O75122 276 1.04e-04 108 2 2 1.000 0.019 GO:0048762 BP 1 mesenchymal cell differentiation 1 Q7Z460,O75122 276 1.04e-04 108 2 2 1.000 0.019 GO:0010632 BP 1 regulation of epithelial cell migration 1 Q7Z460,O75122 276 1.06e-04 109 2 2 1.000 0.018 GO:1905330 BP 1 regulation of morphogenesis of an epithelium 1 Q7Z460,O75122 276 1.14e-04 113 2 2 1.000 0.018 GO:0007160 BP 1 cell-matrix adhesion 1 Q7Z460,O75122 276 1.18e-04 115 2 2 1.000 0.017 GO:0030336 BP 1 negative regulation of cell migration 1 Q7Z460,O75122 276 1.18e-04 115 2 2 1.000 0.017 GO:0005938 CC 1 cell cortex 1 Q7Z460,O75122 276 1.21e-04 116 2 2 1.000 0.017 GO:0007062 BP 1 sister chromatid cohesion 1 Q7Z460,O75122 276 1.31e-04 121 2 2 1.000 0.017 GO:2000146 BP 1 negative regulation of cell motility 1 Q7Z460,O75122 276 1.31e-04 121 2 2 1.000 0.017 GO:0000775 CC 1 chromosome, centromeric region 1 Q7Z460,O75122 276 1.33e-04 122 2 2 1.000 0.016 GO:0099568 CC 1 cytoplasmic region 1 Q7Z460,O75122 276 1.33e-04 122 2 2 1.000 0.016 GO:0008017 MF 1 microtubule binding 1 Q7Z460,O75122 276 1.36e-04 123 2 2 1.000 0.016 GO:0007051 BP 1 spindle organization 1 Q7Z460,O75122 276 1.42e-04 126 2 2 1.000 0.016 GO:0060485 BP 1 mesenchyme development 1 Q7Z460,O75122 276 1.45e-04 127 2 2 1.000 0.016 GO:0034329 BP 1 cell junction assembly 1 Q7Z460,O75122 276 1.45e-04 127 2 2 1.000 0.016 GO:0032102 BP 1 negative regulation of response to external stimulus 1 Q7Z460,O75122 276 1.47e-04 128 2 2 1.000 0.016 GO:1903532 BP 1 positive regulation of secretion by cell 1 Q7Z460,O75122 276 1.56e-04 132 2 2 1.000 0.015 GO:0045216 BP 1 cell-cell junction organization 1 Q7Z460,O75122 276 1.61e-04 134 2 2 1.000 0.015 GO:0051047 BP 1 positive regulation of secretion 1 Q7Z460,O75122 276 1.78e-04 141 2 2 1.000 0.014 GO:0051271 BP 1 negative regulation of cellular component movement 1 Q7Z460,O75122 276 1.86e-04 144 2 2 1.000 0.014 GO:0010631 BP 1 epithelial cell migration 1 Q7Z460,O75122 276 1.89e-04 145 2 2 1.000 0.014 GO:0090132 BP 1 epithelium migration 1 Q7Z460,O75122 276 1.96e-04 99 2 2 1.000 0.020 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q7Z460,O75122 276 1.97e-04 148 2 2 1.000 0.014 GO:0090130 BP 1 tissue migration 1 Q7Z460,O75122 276 2.02e-04 150 2 2 1.000 0.013 GO:0051258 BP 1 protein polymerization 1 Q7Z460,O75122 276 2.07e-04 152 2 2 1.000 0.013 GO:0043624 BP 1 cellular protein complex disassembly 1 Q7Z460,O75122 276 2.07e-04 152 2 2 1.000 0.013 GO:0040013 BP 1 negative regulation of locomotion 1 Q7Z460,O75122 276 2.08e-04 1 2 1 0.500 1.000 GO:0031592 CC 1 centrosomal corona 1 Q7Z460 276 2.18e-04 156 2 2 1.000 0.013 GO:0034330 BP 1 cell junction organization 1 Q7Z460,O75122 276 2.30e-04 107 2 2 1.000 0.019 REAC:68877 rea 1 Mitotic Prometaphase 1 Q7Z460,O75122 276 2.47e-04 166 2 2 1.000 0.012 GO:0005874 CC 1 microtubule 1 Q7Z460,O75122 276 2.47e-04 166 2 2 1.000 0.012 GO:0051650 BP 1 establishment of vesicle localization 1 Q7Z460,O75122 276 2.56e-04 113 2 2 1.000 0.018 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 Q7Z460,O75122 276 2.60e-04 170 2 2 1.000 0.012 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 Q7Z460,O75122 276 2.63e-04 171 2 2 1.000 0.012 GO:0010639 BP 1 negative regulation of organelle organization 1 Q7Z460,O75122 276 2.63e-04 171 2 2 1.000 0.012 GO:0031589 BP 1 cell-substrate adhesion 1 Q7Z460,O75122 276 2.66e-04 172 2 2 1.000 0.012 GO:0015631 MF 1 tubulin binding 1 Q7Z460,O75122 276 2.72e-04 174 2 2 1.000 0.011 GO:0005819 CC 1 spindle 1 Q7Z460,O75122 276 2.75e-04 175 2 2 1.000 0.011 GO:0048598 BP 1 embryonic morphogenesis 1 Q7Z460,O75122 276 2.75e-04 175 2 2 1.000 0.011 GO:0051648 BP 1 vesicle localization 1 Q7Z460,O75122 276 3.04e-04 184 2 2 1.000 0.011 GO:0001667 BP 1 ameboidal-type cell migration 1 Q7Z460,O75122 276 3.08e-04 185 2 2 1.000 0.011 GO:0043241 BP 1 protein complex disassembly 1 Q7Z460,O75122 276 3.35e-04 193 2 2 1.000 0.010 GO:0032970 BP 1 regulation of actin filament-based process 1 Q7Z460,O75122 276 3.45e-04 196 2 2 1.000 0.010 GO:0000819 BP 1 sister chromatid segregation 1 Q7Z460,O75122 276 3.74e-04 204 2 2 1.000 0.010 GO:0043062 BP 1 extracellular structure organization 1 Q7Z460,O75122 276 3.74e-04 204 2 2 1.000 0.010 GO:0030198 BP 1 extracellular matrix organization 1 Q7Z460,O75122 276 3.93e-04 209 2 2 1.000 0.010 GO:0032984 BP 1 macromolecular complex disassembly 1 Q7Z460,O75122 276 4.04e-04 212 2 2 1.000 0.009 GO:0007015 BP 1 actin filament organization 1 Q7Z460,O75122 276 4.17e-04 2 2 1 0.500 0.500 GO:0030981 CC 1 cortical microtubule cytoskeleton 1 Q7Z460 276 4.39e-04 221 2 2 1.000 0.009 GO:0030335 BP 1 positive regulation of cell migration 1 Q7Z460,O75122 276 4.39e-04 221 2 2 1.000 0.009 GO:0002009 BP 1 morphogenesis of an epithelium 1 Q7Z460,O75122 276 4.59e-04 226 2 2 1.000 0.009 GO:0098813 BP 1 nuclear chromosome segregation 1 Q7Z460,O75122 276 4.63e-04 227 2 2 1.000 0.009 GO:2000147 BP 1 positive regulation of cell motility 1 Q7Z460,O75122 276 4.76e-04 230 2 2 1.000 0.009 GO:0098687 CC 1 chromosomal region 1 Q7Z460,O75122 276 4.93e-04 234 2 2 1.000 0.009 GO:0051272 BP 1 positive regulation of cellular component movement 1 Q7Z460,O75122 276 5.01e-04 236 2 2 1.000 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q7Z460,O75122 276 5.21e-04 161 2 2 1.000 0.012 REAC:2467813 rea 1 Separation of Sister Chromatids 1 Q7Z460,O75122 276 5.36e-04 244 2 2 1.000 0.008 GO:0006887 BP 1 exocytosis 1 Q7Z460,O75122 276 5.45e-04 246 2 2 1.000 0.008 GO:0040017 BP 1 positive regulation of locomotion 1 Q7Z460,O75122 276 5.95e-04 172 2 2 1.000 0.012 REAC:68882 rea 1 Mitotic Anaphase 1 Q7Z460,O75122 276 6.02e-04 173 2 2 1.000 0.012 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 Q7Z460,O75122 276 6.23e-04 263 2 2 1.000 0.008 GO:0007059 BP 1 chromosome segregation 1 Q7Z460,O75122 276 6.27e-04 264 2 2 1.000 0.008 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 Q7Z460,O75122 276 6.32e-04 265 2 2 1.000 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q7Z460,O75122 276 6.37e-04 266 2 2 1.000 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 Q7Z460,O75122 276 6.51e-04 269 2 2 1.000 0.007 GO:0048729 BP 1 tissue morphogenesis 1 Q7Z460,O75122 276 6.56e-04 270 2 2 1.000 0.007 GO:1903530 BP 1 regulation of secretion by cell 1 Q7Z460,O75122 276 6.76e-04 274 2 2 1.000 0.007 GO:0099081 CC 1 supramolecular polymer 1 Q7Z460,O75122 276 6.76e-04 274 2 2 1.000 0.007 GO:0099512 CC 1 supramolecular fiber 1 Q7Z460,O75122 276 7.11e-04 281 2 2 1.000 0.007 GO:0009790 BP 1 embryo development 1 Q7Z460,O75122 276 7.31e-04 285 2 2 1.000 0.007 GO:0060627 BP 1 regulation of vesicle-mediated transport 1 Q7Z460,O75122 276 7.31e-04 285 2 2 1.000 0.007 GO:0051046 BP 1 regulation of secretion 1 Q7Z460,O75122 276 7.52e-04 289 2 2 1.000 0.007 GO:0051656 BP 1 establishment of organelle localization 1 Q7Z460,O75122 276 7.78e-04 294 2 2 1.000 0.007 GO:0099080 CC 1 supramolecular complex 1 Q7Z460,O75122 276 8.05e-04 299 2 2 1.000 0.007 GO:0030155 BP 1 regulation of cell adhesion 1 Q7Z460,O75122 276 8.10e-04 300 2 2 1.000 0.007 GO:0042060 BP 1 wound healing 1 Q7Z460,O75122 276 8.34e-04 4 2 1 0.500 0.250 GO:0043515 MF 1 kinetochore binding 1 Q7Z460 276 8.60e-04 309 2 2 1.000 0.006 GO:0000280 BP 1 nuclear division 1 Q7Z460,O75122 276 9.81e-04 330 2 2 1.000 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q7Z460,O75122 276 9.87e-04 331 2 2 1.000 0.006 GO:0051640 BP 1 organelle localization 1 Q7Z460,O75122 276 9.99e-04 333 2 2 1.000 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 Q7Z460,O75122 276 9.99e-04 333 2 2 1.000 0.006 GO:0005925 CC 1 focal adhesion 1 Q7Z460,O75122 276 1.00e-03 334 2 2 1.000 0.006 GO:0009611 BP 1 response to wounding 1 Q7Z460,O75122 276 1.02e-03 337 2 2 1.000 0.006 GO:0030055 CC 1 cell-substrate junction 1 Q7Z460,O75122 276 1.02e-03 337 2 2 1.000 0.006 GO:0051093 BP 1 negative regulation of developmental process 1 Q7Z460,O75122 276 1.04e-03 340 2 2 1.000 0.006 GO:0048285 BP 1 organelle fission 1 Q7Z460,O75122 276 1.04e-03 5 2 1 0.500 0.200 GO:0030953 BP 1 astral microtubule organization 1 Q7Z460 276 1.08e-03 231 2 2 1.000 0.009 REAC:195258 rea 1 RHO GTPase Effectors 1 Q7Z460,O75122 276 1.08e-03 347 2 2 1.000 0.006 GO:0032101 BP 1 regulation of response to external stimulus 1 Q7Z460,O75122 276 1.15e-03 358 2 2 1.000 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 Q7Z460,O75122 276 1.16e-03 359 2 2 1.000 0.006 GO:0051129 BP 1 negative regulation of cellular component organization 1 Q7Z460,O75122 276 1.23e-03 370 2 2 1.000 0.005 GO:0030334 BP 1 regulation of cell migration 1 Q7Z460,O75122 276 1.29e-03 253 2 2 1.000 0.008 REAC:68886 rea 1 M Phase 1 Q7Z460,O75122 276 1.31e-03 382 2 2 1.000 0.005 GO:0048646 BP 1 anatomical structure formation involved in morphogenesis 1 Q7Z460,O75122 276 1.38e-03 391 2 2 1.000 0.005 GO:0043623 BP 1 cellular protein complex assembly 1 Q7Z460,O75122 276 1.47e-03 404 2 2 1.000 0.005 GO:2000145 BP 1 regulation of cell motility 1 Q7Z460,O75122 276 1.47e-03 404 2 2 1.000 0.005 GO:0010256 BP 1 endomembrane system organization 1 Q7Z460,O75122 276 1.52e-03 411 2 2 1.000 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q7Z460,O75122 276 1.58e-03 419 2 2 1.000 0.005 GO:0030029 BP 1 actin filament-based process 1 Q7Z460,O75122 276 1.63e-03 425 2 2 1.000 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q7Z460,O75122 276 1.64e-03 426 2 2 1.000 0.005 GO:0022411 BP 1 cellular component disassembly 1 Q7Z460,O75122 276 1.73e-03 438 2 2 1.000 0.005 GO:0051270 BP 1 regulation of cellular component movement 1 Q7Z460,O75122 276 1.74e-03 439 2 2 1.000 0.005 GO:0060429 BP 1 epithelium development 1 Q7Z460,O75122 276 1.76e-03 442 2 2 1.000 0.005 GO:0040012 BP 1 regulation of locomotion 1 Q7Z460,O75122 276 1.79e-03 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 Q7Z460,O75122 276 1.90e-03 459 2 2 1.000 0.004 GO:0007017 BP 1 microtubule-based process 1 Q7Z460,O75122 276 1.94e-03 464 2 2 1.000 0.004 GO:0032940 BP 1 secretion by cell 1 Q7Z460,O75122 276 2.10e-03 483 2 2 1.000 0.004 GO:0051050 BP 1 positive regulation of transport 1 Q7Z460,O75122 276 2.12e-03 485 2 2 1.000 0.004 GO:0008092 MF 1 cytoskeletal protein binding 1 Q7Z460,O75122 276 2.17e-03 491 2 2 1.000 0.004 GO:0046903 BP 1 secretion 1 Q7Z460,O75122 276 2.26e-03 501 2 2 1.000 0.004 GO:0051094 BP 1 positive regulation of developmental process 1 Q7Z460,O75122 276 2.29e-03 504 2 2 1.000 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q7Z460,O75122 276 2.29e-03 11 2 1 0.500 0.091 GO:0031116 BP 1 positive regulation of microtubule polymerization 1 Q7Z460 276 2.31e-03 338 2 2 1.000 0.006 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q7Z460,O75122 276 2.39e-03 515 2 2 1.000 0.004 GO:0032989 BP 1 cellular component morphogenesis 1 Q7Z460,O75122 276 2.47e-03 523 2 2 1.000 0.004 GO:0022603 BP 1 regulation of anatomical structure morphogenesis 1 Q7Z460,O75122 276 2.50e-03 12 2 1 0.500 0.083 GO:0090162 BP 1 establishment of epithelial cell polarity 1 Q7Z460 276 2.63e-03 540 2 2 1.000 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 Q7Z460,O75122 276 2.71e-03 13 2 1 0.500 0.077 GO:0051895 BP 1 negative regulation of focal adhesion assembly 1 O75122 276 2.71e-03 13 2 1 0.500 0.077 GO:0031112 BP 1 positive regulation of microtubule polymerization or depolymerization 1 Q7Z460 276 2.71e-03 13 2 1 0.500 0.077 GO:0035371 CC 1 microtubule plus-end 1 Q7Z460 276 2.88e-03 565 2 2 1.000 0.004 GO:0044427 CC 1 chromosomal part 1 Q7Z460,O75122 276 2.92e-03 14 2 1 0.500 0.071 GO:1903392 BP 1 negative regulation of adherens junction organization 1 O75122 276 3.05e-03 582 2 2 1.000 0.003 GO:0005912 CC 1 adherens junction 1 Q7Z460,O75122 276 3.14e-03 20 2 1 0.500 0.050 TF:M05783_0 tf 1 Factor: ZNF667; motif: KGGGSCATTATC; match class: 0 1 Q7Z460 276 3.15e-03 591 2 2 1.000 0.003 GO:0070161 CC 1 anchoring junction 1 Q7Z460,O75122 276 3.33e-03 16 2 1 0.500 0.062 GO:0040001 BP 1 establishment of mitotic spindle localization 1 Q7Z460 276 3.35e-03 609 2 2 1.000 0.003 GO:0005694 CC 1 chromosome 1 Q7Z460,O75122 276 3.51e-03 624 2 2 1.000 0.003 GO:0051240 BP 1 positive regulation of multicellular organismal process 1 Q7Z460,O75122 276 3.54e-03 17 2 1 0.500 0.059 GO:1901889 BP 1 negative regulation of cell junction assembly 1 O75122 276 3.54e-03 17 2 1 0.500 0.059 GO:0031113 BP 1 regulation of microtubule polymerization 1 Q7Z460 276 3.69e-03 640 2 2 1.000 0.003 GO:0016477 BP 1 cell migration 1 Q7Z460,O75122 276 3.75e-03 18 2 1 0.500 0.056 GO:0051294 BP 1 establishment of spindle orientation 1 Q7Z460 276 3.89e-03 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q7Z460,O75122 276 3.96e-03 19 2 1 0.500 0.053 GO:1990752 CC 1 microtubule end 1 Q7Z460 276 4.05e-03 448 2 2 1.000 0.004 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q7Z460,O75122 276 4.15e-03 678 2 2 1.000 0.003 GO:0007155 BP 1 cell adhesion 1 Q7Z460,O75122 276 4.16e-03 20 2 1 0.500 0.050 GO:0001953 BP 1 negative regulation of cell-matrix adhesion 1 O75122 276 4.22e-03 684 2 2 1.000 0.003 GO:0022610 BP 1 biological adhesion 1 Q7Z460,O75122 276 4.26e-03 459 2 2 1.000 0.004 REAC:422475 rea 1 Axon guidance 1 Q7Z460,O75122 276 4.28e-03 689 2 2 1.000 0.003 GO:0034622 BP 1 cellular macromolecular complex assembly 1 Q7Z460,O75122 276 4.42e-03 700 2 2 1.000 0.003 GO:0045595 BP 1 regulation of cell differentiation 1 Q7Z460,O75122 276 4.51e-03 707 2 2 1.000 0.003 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q7Z460,O75122 276 4.51e-03 707 2 2 1.000 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q7Z460,O75122 276 4.56e-03 711 2 2 1.000 0.003 GO:0051674 BP 1 localization of cell 1 Q7Z460,O75122 276 4.56e-03 711 2 2 1.000 0.003 GO:0048870 BP 1 cell motility 1 Q7Z460,O75122 276 4.69e-03 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q7Z460,O75122 276 5.02e-03 746 2 2 1.000 0.003 GO:0030054 CC 1 cell junction 1 Q7Z460,O75122 276 5.02e-03 32 2 1 0.500 0.031 TF:M06708_0 tf 1 Factor: ZNF355P; motif: NSGTGGAACCGM; match class: 0 1 O75122 276 5.09e-03 751 2 2 1.000 0.003 GO:0009888 BP 1 tissue development 1 Q7Z460,O75122 276 5.18e-03 758 2 2 1.000 0.003 GO:0007010 BP 1 cytoskeleton organization 1 Q7Z460,O75122 276 5.20e-03 25 2 1 0.500 0.040 GO:0051293 BP 1 establishment of spindle localization 1 Q7Z460 276 5.34e-03 769 2 2 1.000 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 Q7Z460,O75122 276 5.36e-03 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 Q7Z460,O75122 276 5.41e-03 774 2 2 1.000 0.003 GO:2000026 BP 1 regulation of multicellular organismal development 1 Q7Z460,O75122 276 5.41e-03 26 2 1 0.500 0.038 GO:0051653 BP 1 spindle localization 1 Q7Z460 276 5.42e-03 775 2 2 1.000 0.003 GO:0048585 BP 1 negative regulation of response to stimulus 1 Q7Z460,O75122 276 5.98e-03 814 2 2 1.000 0.002 GO:0080134 BP 1 regulation of response to stress 1 Q7Z460,O75122 276 5.98e-03 814 2 2 1.000 0.002 GO:0040011 BP 1 locomotion 1 Q7Z460,O75122 276 6.05e-03 547 2 2 1.000 0.004 REAC:1640170 rea 1 Cell Cycle 1 Q7Z460,O75122 276 6.24e-03 30 2 1 0.500 0.033 GO:0031122 BP 1 cytoplasmic microtubule organization 1 Q7Z460 276 6.29e-03 835 2 2 1.000 0.002 GO:0009605 BP 1 response to external stimulus 1 Q7Z460,O75122 276 6.40e-03 842 2 2 1.000 0.002 GO:0070271 BP 1 protein complex biogenesis 1 Q7Z460,O75122 276 6.40e-03 842 2 2 1.000 0.002 GO:0006461 BP 1 protein complex assembly 1 Q7Z460,O75122 276 6.45e-03 31 2 1 0.500 0.032 GO:0010812 BP 1 negative regulation of cell-substrate adhesion 1 O75122 276 6.46e-03 846 2 2 1.000 0.002 GO:0005794 CC 1 Golgi apparatus 1 Q7Z460,O75122 276 7.86e-03 933 2 2 1.000 0.002 GO:0044430 CC 1 cytoskeletal part 1 Q7Z460,O75122 276 7.91e-03 936 2 2 1.000 0.002 GO:0051049 BP 1 regulation of transport 1 Q7Z460,O75122 276 8.02e-03 1140 2 2 1.000 0.002 TF:M00472_1 tf 1 Factor: FOXO4; motif: RWAAACAANNN; match class: 1 1 Q7Z460,O75122 276 8.18e-03 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 Q7Z460,O75122 276 8.28e-03 958 2 2 1.000 0.002 GO:0016192 BP 1 vesicle-mediated transport 1 Q7Z460,O75122 276 8.32e-03 40 2 1 0.500 0.025 GO:0032587 CC 1 ruffle membrane 1 O75122 276 8.95e-03 43 2 1 0.500 0.023 GO:0072686 CC 1 mitotic spindle 1 O75122 276 9.25e-03 59 2 1 0.500 0.017 TF:M04046_0 tf 1 Factor: MYBL2; motif: AACSGTTAACSGNY; match class: 0 1 Q7Z460 276 9.30e-03 1015 2 2 1.000 0.002 GO:0071822 BP 1 protein complex subunit organization 1 Q7Z460,O75122 276 9.32e-03 1016 2 2 1.000 0.002 GO:0006928 BP 1 movement of cell or subcellular component 1 Q7Z460,O75122 276 9.56e-03 61 2 1 0.500 0.016 TF:M06022_0 tf 1 Factor: ZNF729; motif: NTGTMWAGAAGA; match class: 0 1 O75122 276 9.56e-03 61 2 1 0.500 0.016 TF:M06740_0 tf 1 Factor: ZNF492; motif: NTGTMWAGAAGA; match class: 0 1 O75122 276 1.03e-02 1067 2 2 1.000 0.002 GO:0050793 BP 1 regulation of developmental process 1 Q7Z460,O75122 276 1.03e-02 66 2 1 0.500 0.015 TF:M04251_0 tf 1 Factor: FOXJ3; motif: GTAAACATAAACA; match class: 0 1 Q7Z460 276 1.04e-02 50 2 1 0.500 0.020 GO:0030863 CC 1 cortical cytoskeleton 1 Q7Z460 276 1.04e-02 718 2 2 1.000 0.003 REAC:1266738 rea 1 Developmental Biology 1 Q7Z460,O75122 276 1.06e-02 51 2 1 0.500 0.020 GO:0001578 BP 1 microtubule bundle formation 1 Q7Z460 276 1.10e-02 53 2 1 0.500 0.019 GO:0090307 BP 1 mitotic spindle assembly 1 Q7Z460 276 1.11e-02 1107 2 2 1.000 0.002 GO:0009653 BP 1 anatomical structure morphogenesis 1 Q7Z460,O75122 276 1.12e-02 1113 2 2 1.000 0.002 GO:0065003 BP 1 macromolecular complex assembly 1 Q7Z460,O75122 276 1.12e-02 1113 2 2 1.000 0.002 GO:0048513 BP 1 animal organ development 1 Q7Z460,O75122 276 1.12e-02 54 2 1 0.500 0.019 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 Q7Z460 276 1.14e-02 1361 2 2 1.000 0.001 TF:M07379_1 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 1 1 Q7Z460,O75122 276 1.14e-02 55 2 1 0.500 0.018 GO:0031256 CC 1 leading edge membrane 1 O75122 276 1.15e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 Q7Z460,O75122 276 1.18e-02 1382 2 2 1.000 0.001 TF:M01659_1 tf 1 Factor: Cdx-2; motif: BNNATAAANRN; match class: 1 1 Q7Z460,O75122 276 1.23e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 Q7Z460,O75122 276 1.31e-02 1204 2 2 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 Q7Z460,O75122 276 1.31e-02 63 2 1 0.500 0.016 GO:0030010 BP 1 establishment of cell polarity 1 Q7Z460 276 1.37e-02 66 2 1 0.500 0.015 GO:0032273 BP 1 positive regulation of protein polymerization 1 Q7Z460 276 1.44e-02 1263 2 2 1.000 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 Q7Z460,O75122 276 1.50e-02 96 2 1 0.500 0.010 TF:M06567_0 tf 1 Factor: ZNF707; motif: NASTCMTAAAGA; match class: 0 1 O75122 276 1.58e-02 76 2 1 0.500 0.013 GO:0051225 BP 1 spindle assembly 1 Q7Z460 276 1.62e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 Q7Z460,O75122 276 1.74e-02 84 2 1 0.500 0.012 GO:0001726 CC 1 ruffle 1 O75122 276 1.75e-02 112 2 1 0.500 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 O75122 276 1.87e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 Q7Z460,O75122 276 1.92e-02 66 2 1 0.500 0.015 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 Q7Z460 276 1.92e-02 66 2 1 0.500 0.015 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 Q7Z460 276 2.01e-02 69 2 1 0.500 0.014 REAC:8854518 rea 1 AURKA Activation by TPX2 1 Q7Z460 276 2.01e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 Q7Z460,O75122 276 2.03e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 Q7Z460,O75122 276 2.05e-02 99 2 1 0.500 0.010 GO:0032271 BP 1 regulation of protein polymerization 1 Q7Z460 276 2.05e-02 99 2 1 0.500 0.010 GO:0007162 BP 1 negative regulation of cell adhesion 1 O75122 276 2.10e-02 1524 2 2 1.000 0.001 GO:0030154 BP 1 cell differentiation 1 Q7Z460,O75122 276 2.10e-02 1847 2 2 1.000 0.001 TF:M01872_1 tf 1 Factor: DBP; motif: TTWTGYAA; match class: 1 1 Q7Z460,O75122 276 2.18e-02 105 2 1 0.500 0.010 GO:0090002 BP 1 establishment of protein localization to plasma membrane 1 O75122 276 2.18e-02 75 2 1 0.500 0.013 REAC:380287 rea 1 Centrosome maturation 1 Q7Z460 276 2.18e-02 75 2 1 0.500 0.013 REAC:380270 rea 1 Recruitment of mitotic centrosome proteins and complexes 1 Q7Z460 276 2.19e-02 1883 2 2 1.000 0.001 TF:M04623_0 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 0 1 Q7Z460,O75122 276 2.19e-02 1883 2 2 1.000 0.001 TF:M04505_0 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 0 1 Q7Z460,O75122 276 2.22e-02 107 2 1 0.500 0.009 GO:0031253 CC 1 cell projection membrane 1 O75122 276 2.28e-02 110 2 1 0.500 0.009 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 Q7Z460 276 2.32e-02 1939 2 2 1.000 0.001 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 Q7Z460,O75122 276 2.34e-02 150 2 1 0.500 0.007 TF:M00292_1 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 1 1 O75122 276 2.35e-02 1614 2 2 1.000 0.001 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q7Z460,O75122 276 2.36e-02 114 2 1 0.500 0.009 GO:0044450 CC 1 microtubule organizing center part 1 Q7Z460 276 2.39e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 Q7Z460 276 2.41e-02 83 2 1 0.500 0.012 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 Q7Z460 276 2.44e-02 156 2 1 0.500 0.006 TF:M00113_1 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 1 1 O75122 276 2.46e-02 1649 2 2 1.000 0.001 GO:0048869 BP 1 cellular developmental process 1 Q7Z460,O75122 276 2.46e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 Q7Z460,O75122 276 2.52e-02 2022 2 2 1.000 0.001 TF:M00141_0 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 0 1 Q7Z460,O75122 276 2.54e-02 163 2 1 0.500 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 O75122 276 2.62e-02 2059 2 2 1.000 0.001 TF:M04355_0 tf 1 Factor: HOXC12; motif: GYAATAAAA; match class: 0 1 Q7Z460,O75122 276 2.62e-02 2059 2 2 1.000 0.001 TF:M07377_0 tf 1 Factor: cdx-1; motif: NTTTATKNN; match class: 0 1 Q7Z460,O75122 276 2.63e-02 1706 2 2 1.000 0.001 GO:0022607 BP 1 cellular component assembly 1 Q7Z460,O75122 276 2.67e-02 92 2 1 0.500 0.011 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 Q7Z460 276 2.89e-02 2166 2 2 1.000 0.001 TF:M03891_1 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 1 1 Q7Z460,O75122 276 2.94e-02 142 2 1 0.500 0.007 GO:0072659 BP 1 protein localization to plasma membrane 1 O75122 276 2.96e-02 1810 2 2 1.000 0.001 GO:0048731 BP 1 system development 1 Q7Z460,O75122 276 2.96e-02 143 2 1 0.500 0.007 GO:0031334 BP 1 positive regulation of protein complex assembly 1 Q7Z460 276 3.04e-02 1836 2 2 1.000 0.001 GO:0051641 BP 1 cellular localization 1 Q7Z460,O75122 276 3.04e-02 147 2 1 0.500 0.007 GO:0005802 CC 1 trans-Golgi network 1 O75122 276 3.15e-02 152 2 1 0.500 0.007 GO:1990778 BP 1 protein localization to cell periphery 1 O75122 276 3.15e-02 2261 2 2 1.000 0.001 TF:M03548_0 tf 1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 0 1 Q7Z460,O75122 276 3.19e-02 154 2 1 0.500 0.006 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 Q7Z460 276 3.33e-02 161 2 1 0.500 0.006 GO:0044839 BP 1 cell cycle G2/M phase transition 1 Q7Z460 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04253_1 tf 1 Factor: FOXL1; motif: RTAAACA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04267_1 tf 1 Factor: FOXP3; motif: RTAAACA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04244_1 tf 1 Factor: FOXI1; motif: GTAAACA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04262_1 tf 1 Factor: FOXO4; motif: GTAAACA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04241_1 tf 1 Factor: FOXD3; motif: GTAAAYA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04265_1 tf 1 Factor: FOXO6; motif: GTAAACA; match class: 1 1 Q7Z460,O75122 276 3.36e-02 2333 2 2 1.000 0.001 TF:M04239_1 tf 1 Factor: FOXD2; motif: GTAAACA; match class: 1 1 Q7Z460,O75122 276 3.37e-02 1932 2 2 1.000 0.001 GO:0044085 BP 1 cellular component biogenesis 1 Q7Z460,O75122 276 3.38e-02 217 2 1 0.500 0.005 TF:M00141_1 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 1 1 O75122 276 3.43e-02 166 2 1 0.500 0.006 GO:0051301 BP 1 cell division 1 Q7Z460 276 3.47e-02 1960 2 2 1.000 0.001 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q7Z460,O75122 276 3.47e-02 1960 2 2 1.000 0.001 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q7Z460,O75122 276 3.50e-02 169 2 1 0.500 0.006 GO:0098791 CC 1 Golgi subcompartment 1 O75122 276 3.56e-02 172 2 1 0.500 0.006 GO:0007009 BP 1 plasma membrane organization 1 O75122 276 3.64e-02 2007 2 2 1.000 0.001 GO:0007275 BP 1 multicellular organism development 1 Q7Z460,O75122 276 3.64e-02 176 2 1 0.500 0.006 GO:0031252 CC 1 cell leading edge 1 O75122 276 3.76e-02 182 2 1 0.500 0.005 GO:0031984 CC 1 organelle subcompartment 1 O75122 276 3.80e-02 244 2 1 0.500 0.004 TF:M00514_1 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 1 1 O75122 276 3.82e-02 2487 2 2 1.000 0.001 TF:M04255_0 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 0 1 Q7Z460,O75122 276 3.82e-02 2487 2 2 1.000 0.001 TF:M04259_0 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 0 1 Q7Z460,O75122 276 3.82e-02 2487 2 2 1.000 0.001 TF:M04247_0 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 0 1 Q7Z460,O75122 276 3.87e-02 2071 2 2 1.000 0.001 GO:0006950 BP 1 response to stress 1 Q7Z460,O75122 276 3.97e-02 2096 2 2 1.000 0.001 GO:0043234 CC 1 protein complex 1 Q7Z460,O75122 276 3.99e-02 2101 2 2 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 Q7Z460,O75122 276 4.01e-02 258 2 1 0.500 0.004 TF:M06275_0 tf 1 Factor: ZNF284; motif: NGGGGGTGGTGM; match class: 0 1 Q7Z460 276 4.26e-02 2626 2 2 1.000 0.001 TF:M00477_0 tf 1 Factor: FOXO3; motif: TNNTTGTTTACNTW; match class: 0 1 Q7Z460,O75122 276 4.40e-02 283 2 1 0.500 0.004 TF:M00424_0 tf 1 Factor: Nkx6-1; motif: TWTTTAATTGGTT; match class: 0 1 O75122 276 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 Q7Z460 276 4.47e-02 2690 2 2 1.000 0.001 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 Q7Z460,O75122 276 4.61e-02 2260 2 2 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 Q7Z460,O75122 276 4.62e-02 2262 2 2 1.000 0.001 GO:0006996 BP 1 organelle organization 1 Q7Z460,O75122 276 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q7Z460 276 4.73e-02 229 2 1 0.500 0.004 GO:0043254 BP 1 regulation of protein complex assembly 1 Q7Z460 276 4.81e-02 310 2 1 0.500 0.003 TF:M00808_1 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 1 1 O75122 276 4.85e-02 2804 2 2 1.000 0.001 TF:M04298_0 tf 1 Factor: Cdx-2; motif: GYMATAAAA; match class: 0 1 Q7Z460,O75122 276 4.94e-02 171 2 1 0.500 0.006 REAC:69275 rea 1 G2/M Transition 1 Q7Z460 276 5.00e-02 173 2 1 0.500 0.006 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 Q7Z460 276 5.00e-02 173 2 1 0.500 0.006 REAC:5617833 rea 1 Assembly of the primary cilium 1 Q7Z460 277 2.18e-03 101 3 2 0.667 0.020 GO:0007088 BP 1 regulation of mitotic nuclear division 1 Q15398,P18754 277 2.45e-03 107 3 2 0.667 0.019 GO:0051783 BP 1 regulation of nuclear division 1 Q15398,P18754 277 7.51e-03 3 3 1 0.333 0.333 GO:0007079 BP 1 mitotic chromosome movement towards spindle pole 1 Q15398 277 7.65e-03 555 3 2 0.667 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 Q9H6Z4,P18754 277 1.00e-02 4 3 1 0.333 0.250 GO:0051305 BP 1 chromosome movement towards spindle pole 1 Q15398 277 1.07e-02 658 3 2 0.667 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 Q9H6Z4,P18754 277 1.19e-02 236 3 2 0.667 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q15398,P18754 277 1.25e-02 5 3 1 0.333 0.200 GO:0005087 MF 1 Ran guanyl-nucleotide exchange factor activity 1 P18754 277 1.47e-02 263 3 2 0.667 0.008 GO:0007059 BP 1 chromosome segregation 1 Q15398,P18754 277 1.50e-02 6 3 1 0.333 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q15398 277 1.50e-02 6 3 1 0.333 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q15398 277 1.50e-02 6 3 1 0.333 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q15398 277 2.00e-02 8 3 1 0.333 0.125 GO:0031616 CC 1 spindle pole centrosome 1 Q15398 277 2.02e-02 913 3 2 0.667 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q9H6Z4,P18754 277 2.03e-02 309 3 2 0.667 0.006 GO:0000280 BP 1 nuclear division 1 Q15398,P18754 277 2.08e-02 927 3 2 0.667 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 Q9H6Z4,P18754 277 2.22e-02 958 3 2 0.667 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q9H6Z4,P18754 277 2.42e-02 1002 3 2 0.667 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q9H6Z4,P18754 277 2.45e-02 340 3 2 0.667 0.006 GO:0048285 BP 1 organelle fission 1 Q15398,P18754 277 2.79e-02 363 3 2 0.667 0.006 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q15398,P18754 277 3.00e-02 12 3 1 0.333 0.083 GO:0046827 BP 1 positive regulation of protein export from nucleus 1 Q9H6Z4 277 3.42e-02 402 3 2 0.667 0.005 GO:0010564 BP 1 regulation of cell cycle process 1 Q15398,P18754 277 3.47e-02 3521 3 3 1.000 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q9H6Z4,Q15398,P18754 277 3.55e-02 1221 3 2 0.667 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q9H6Z4,P18754 277 3.57e-02 411 3 2 0.667 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q15398,P18754 277 3.66e-02 1242 3 2 0.667 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q9H6Z4,P18754 277 3.69e-02 1247 3 2 0.667 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q9H6Z4,P18754 277 3.75e-02 15 3 1 0.333 0.067 GO:0070412 MF 1 R-SMAD binding 1 Q9H6Z4 277 3.82e-02 425 3 2 0.667 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q15398,P18754 277 3.95e-02 1291 3 2 0.667 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 Q9H6Z4,P18754 277 4.04e-02 1307 3 2 0.667 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q9H6Z4,P18754 277 4.10e-02 1317 3 2 0.667 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 Q9H6Z4,P18754 277 4.22e-02 1337 3 2 0.667 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q9H6Z4,P18754 277 4.44e-02 459 3 2 0.667 0.004 GO:0007017 BP 1 microtubule-based process 1 Q15398,P18754 277 4.58e-02 1396 3 2 0.667 0.001 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q9H6Z4,P18754 277 4.58e-02 1396 3 2 0.667 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9H6Z4,P18754 277 4.66e-02 1408 3 2 0.667 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q9H6Z4,P18754 277 4.73e-02 1419 3 2 0.667 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q9H6Z4,P18754 277 4.85e-02 32 3 1 0.333 0.031 REAC:180746 rea 1 Nuclear import of Rev protein 1 P18754 277 4.98e-02 1459 3 2 0.667 0.001 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q9H6Z4,P18754 277 5.00e-02 33 3 1 0.333 0.030 REAC:165054 rea 1 Rev-mediated nuclear export of HIV RNA 1 P18754 277 5.00e-02 413 3 3 1.000 0.007 MI:hsa-miR-541 mi 1 MI:hsa-miR-541 1 Q9H6Z4,Q15398,P18754 277 5.00e-02 4 3 1 0.333 0.250 TF:M00999_1 tf 1 Factor: AIRE; motif: WTNNNWNNTGGWWNNNWNGGNNWNWN; match class: 1 1 Q15398 277 5.00e-02 20 3 1 0.333 0.050 GO:0051984 BP 1 positive regulation of chromosome segregation 1 Q15398 277 5.00e-02 20 3 1 0.333 0.050 GO:0046825 BP 1 regulation of protein export from nucleus 1 Q9H6Z4 278 4.44e-03 418 9 3 0.333 0.007 MI:hsa-miR-496 mi 1 MI:hsa-miR-496 1 Q5JW98,Q86SJ6,Q86SG7 278 4.44e-03 418 9 3 0.333 0.007 MI:hsa-miR-100 mi 1 MI:hsa-miR-100 1 Q13835,Q86SJ6,Q86SG7 278 7.21e-03 1 9 1 0.111 1.000 OMIM:604536 omi 1 ECTODERMAL DYSPLASIA/SKIN FRAGILITY SYNDROME;;MCGRATH SYNDROME 1 Q13835 278 8.35e-03 1 9 1 0.111 1.000 GO:0004668 MF 1 protein-arginine deiminase activity 1 Q9ULW8 278 1.44e-02 2 9 1 0.111 0.500 OMIM:607903 omi 1 Autosomal Recessive Localized Hypotrichosis 1 Q86SJ6 278 2.50e-02 3 9 1 0.111 0.333 GO:0016724 MF 1 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 1 Q6MZM0 278 2.50e-02 3 9 1 0.111 0.333 GO:0004322 MF 1 ferroxidase activity 1 Q6MZM0 278 2.94e-02 311 9 2 0.222 0.006 MI:hsa-miR-183* mi 1 MI:hsa-miR-183* 1 Q13835,Q9ULW8 278 3.34e-02 4 9 1 0.111 0.250 GO:0046813 BP 1 receptor-mediated virion attachment to host cell 1 Q8TF66 278 3.34e-02 4 9 1 0.111 0.250 GO:0030280 MF 1 structural constituent of epidermis 1 Q13835 278 3.75e-02 354 9 2 0.222 0.006 MI:hsa-miR-93* mi 1 MI:hsa-miR-93* 1 Q86SG7,P33764 278 3.93e-02 363 9 2 0.222 0.006 MI:hsa-miR-150* mi 1 MI:hsa-miR-150* 1 Q9ULW8,P33764 278 4.03e-02 1 9 1 0.111 1.000 TF:M01023_1 tf 1 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 1 Q6MZM0 278 4.17e-02 5 9 1 0.111 0.200 GO:0045110 BP 1 intermediate filament bundle assembly 1 Q13835 278 4.25e-02 379 9 2 0.222 0.005 MI:hsa-miR-596 mi 1 MI:hsa-miR-596 1 Q13835,P33764 278 4.31e-02 382 9 2 0.222 0.005 MI:mmu-miR-676 mi 1 MI:mmu-miR-676 1 Q13835,P33764 278 4.52e-02 392 9 2 0.222 0.005 MI:hsa-miR-551b mi 1 MI:hsa-miR-551b 1 Q13835,Q86SJ6 278 4.69e-02 400 9 2 0.222 0.005 MI:mmu-miR-805 mi 1 MI:mmu-miR-805 1 Q86SJ6,P33764 278 4.87e-02 408 9 2 0.222 0.005 MI:hsa-miR-99a mi 1 MI:hsa-miR-99a 1 Q86SJ6,Q86SG7 278 4.89e-02 409 9 2 0.222 0.005 MI:hsa-miR-375 mi 1 MI:hsa-miR-375 1 Q86SJ6,P33764 278 4.93e-02 411 9 2 0.222 0.005 MI:hsa-miR-659 mi 1 MI:hsa-miR-659 1 Q5JW98,Q86SJ6 278 5.00e-02 10 9 1 0.111 0.100 REAC:351906 rea 1 Apoptotic cleavage of cell adhesion proteins 1 Q13835 278 5.00e-02 414 9 2 0.222 0.005 MI:hsa-miR-631 mi 1 MI:hsa-miR-631 1 Q86SG7,P33764 278 5.00e-02 1270 9 5 0.556 0.004 TF:M00517_1 tf 1 Factor: AP-1; motif: NNNTGAGTCAKCN; match class: 1 1 Q9ULW8,Q5JW98,Q8TF66,Q86SG7,O95147 278 5.00e-02 6 9 1 0.111 0.167 GO:0016813 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1 Q9ULW8 278 5.00e-02 7 9 1 0.111 0.143 OMIM:605389 omi 1 Nonsyndromic Hypotrichosis 1 Q86SJ6 278 5.00e-02 15 9 2 0.222 0.133 HP:0002224 hp 1 Woolly hair 1 Q13835,Q86SJ6 279 2.89e-03 603 2 2 1.000 0.003 MI:mmu-miR-466f-5p mi 1 MI:mmu-miR-466f-5p 1 Q9H6R0,Q9P275 279 4.08e-03 7 2 1 0.500 0.143 GO:0000182 MF 1 rDNA binding 1 Q9H6R0 279 8.17e-03 14 2 1 0.500 0.071 GO:0045943 BP 1 positive regulation of transcription from RNA polymerase I promoter 1 Q9H6R0 279 1.05e-02 645 2 2 1.000 0.003 GO:0005730 CC 1 nucleolus 1 Q9H6R0,Q9P275 279 1.28e-02 22 2 1 0.500 0.045 GO:0006356 BP 1 regulation of transcription from RNA polymerase I promoter 1 Q9H6R0 279 1.98e-02 34 2 1 0.500 0.029 GO:1903146 BP 1 regulation of mitophagy 1 Q9P275 279 2.32e-02 13 2 1 0.500 0.077 TF:M06811_0 tf 1 Factor: ZNF528; motif: KGTTAMGGCCGM; match class: 0 1 Q9P275 279 2.86e-02 16 2 1 0.500 0.062 TF:M06535_0 tf 1 Factor: ZNF555; motif: KGGGGCTGCCGN; match class: 0 1 Q9P275 279 2.97e-02 51 2 1 0.500 0.020 GO:0006360 BP 1 transcription from RNA polymerase I promoter 1 Q9H6R0 279 3.16e-02 1118 2 2 1.000 0.002 GO:0044822 MF 1 poly(A) RNA binding 1 Q9H6R0,Q9P275 279 3.72e-02 64 2 1 0.500 0.016 GO:0004843 MF 1 thiol-dependent ubiquitin-specific protease activity 1 Q9P275 279 3.72e-02 64 2 1 0.500 0.016 GO:0036459 MF 1 thiol-dependent ubiquitinyl hydrolase activity 1 Q9P275 279 3.75e-02 21 2 1 0.500 0.048 TF:M00665_1 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 1 Q9P275 279 3.78e-02 65 2 1 0.500 0.015 GO:0004004 MF 1 ATP-dependent RNA helicase activity 1 Q9H6R0 279 3.84e-02 66 2 1 0.500 0.015 GO:0008186 MF 1 RNA-dependent ATPase activity 1 Q9H6R0 279 3.84e-02 66 2 1 0.500 0.015 GO:0003724 MF 1 RNA helicase activity 1 Q9H6R0 279 3.84e-02 66 2 1 0.500 0.015 GO:0000422 BP 1 mitophagy 1 Q9P275 279 3.84e-02 66 2 1 0.500 0.015 GO:0061726 BP 1 mitochondrion disassembly 1 Q9P275 279 3.90e-02 67 2 1 0.500 0.015 GO:0101005 MF 1 ubiquitinyl hydrolase activity 1 Q9P275 279 3.96e-02 68 2 1 0.500 0.015 GO:1903955 BP 1 positive regulation of protein targeting to mitochondrion 1 Q9P275 279 4.36e-02 75 2 1 0.500 0.013 GO:1903214 BP 1 regulation of protein targeting to mitochondrion 1 Q9P275 279 4.36e-02 75 2 1 0.500 0.013 GO:0019783 MF 1 ubiquitin-like protein-specific protease activity 1 Q9P275 279 4.51e-02 1336 2 2 1.000 0.001 GO:0003723 MF 1 RNA binding 1 Q9H6R0,Q9P275 279 4.94e-02 85 2 1 0.500 0.012 GO:1903008 BP 1 organelle disassembly 1 Q9P275 279 5.00e-02 28 2 1 0.500 0.036 TF:M05677_0 tf 1 Factor: ZNF816A; motif: KGGGAAAAMGGM; match class: 0 1 Q9H6R0 279 5.00e-02 86 2 1 0.500 0.012 GO:0016579 BP 1 protein deubiquitination 1 Q9P275 279 5.00e-02 28 2 1 0.500 0.036 TF:M07367_1 tf 1 Factor: Slug; motif: SSSNNNKCACCTGN; match class: 1 1 Q9P275 279 5.00e-02 127 2 1 0.500 0.008 KEGG:04621 keg 1 NOD-like receptor signaling pathway 1 Q9H6R0 280 2.33e-06 5 3 2 0.667 0.400 GO:0090286 BP 1 cytoskeletal anchoring at nuclear membrane 1 Q8WXH0,Q8NF91 280 3.50e-06 6 3 2 0.667 0.333 GO:0034993 CC 1 LINC complex 1 Q8WXH0,Q8NF91 280 3.50e-06 6 3 2 0.667 0.333 GO:0034992 CC 1 microtubule organizing center attachment site 1 Q8WXH0,Q8NF91 280 1.17e-05 4 3 2 0.667 0.500 HP:0009049 hp 1 Peroneal muscle atrophy 1 Q8WXH0,Q8NF91 280 1.17e-05 4 3 2 0.667 0.500 HP:0011727 hp 1 Peroneal muscle weakness 1 Q8WXH0,Q8NF91 280 1.94e-05 5 3 2 0.667 0.400 HP:0005144 hp 1 Left ventricular septal hypertrophy 1 Q8WXH0,Q8NF91 280 1.94e-05 5 3 2 0.667 0.400 HP:0005997 hp 1 Restricted neck movement due to contractures 1 Q8WXH0,Q8NF91 280 2.92e-05 6 3 2 0.667 0.333 HP:0004631 hp 1 Decreased cervical spine flexion due to contractures of posterior cervical muscles 1 Q8WXH0,Q8NF91 280 8.74e-05 10 3 2 0.667 0.200 HP:0006785 hp 1 Limb-girdle muscular dystrophy 1 Q8WXH0,Q8NF91 280 1.07e-04 11 3 2 0.667 0.182 HP:0008944 hp 1 Distal lower limb amyotrophy 1 Q8WXH0,Q8NF91 280 1.07e-04 11 3 2 0.667 0.182 HP:0009053 hp 1 Distal lower limb muscle weakness 1 Q8WXH0,Q8NF91 280 1.28e-04 12 3 2 0.667 0.167 HP:0005986 hp 1 Limitation of neck motion 1 Q8WXH0,Q8NF91 280 1.51e-04 13 3 2 0.667 0.154 HP:0007210 hp 1 Lower limb amyotrophy 1 Q8WXH0,Q8NF91 280 3.17e-04 43 3 2 0.667 0.047 REAC:1221632 rea 1 Meiotic synapsis 1 Q8WXH0,Q8NF91 280 3.91e-04 5 3 2 0.667 0.400 OMIM:310300 omi 1 Emery-Dreifuss Muscular Dystrophy 1 Q8WXH0,Q8NF91 280 5.34e-04 24 3 2 0.667 0.083 HP:0003797 hp 1 Limb-girdle muscle atrophy 1 Q8WXH0,Q8NF91 280 5.45e-04 69 3 2 0.667 0.029 GO:0032507 BP 1 maintenance of protein location in cell 1 Q8WXH0,Q8NF91 280 6.11e-04 73 3 2 0.667 0.027 GO:0045185 BP 1 maintenance of protein location 1 Q8WXH0,Q8NF91 280 7.34e-04 80 3 2 0.667 0.025 GO:0051651 BP 1 maintenance of location in cell 1 Q8WXH0,Q8NF91 280 7.85e-04 29 3 2 0.667 0.069 HP:0000467 hp 1 Neck muscle weakness 1 Q8WXH0,Q8NF91 280 7.91e-04 83 3 2 0.667 0.024 GO:0030017 CC 1 sarcomere 1 Q8WXH0,Q8NF91 280 7.98e-04 68 3 2 0.667 0.029 REAC:1500620 rea 1 Meiosis 1 Q8WXH0,Q8NF91 280 8.41e-04 30 3 2 0.667 0.067 HP:0008180 hp 1 Mildly elevated creatine phosphokinase 1 Q8WXH0,Q8NF91 280 9.58e-04 32 3 2 0.667 0.062 HP:0001430 hp 1 Abnormality of the calf musculature 1 Q8WXH0,Q8NF91 280 1.01e-03 94 3 2 0.667 0.021 GO:0030016 CC 1 myofibril 1 Q8WXH0,Q8NF91 280 1.02e-03 33 3 2 0.667 0.061 HP:0001662 hp 1 Bradycardia 1 Q8WXH0,Q8NF91 280 1.04e-03 95 3 2 0.667 0.021 GO:0044449 CC 1 contractile fiber part 1 Q8WXH0,Q8NF91 280 1.15e-03 35 3 2 0.667 0.057 HP:0003306 hp 1 Spinal rigidity 1 Q8WXH0,Q8NF91 280 1.17e-03 101 3 2 0.667 0.020 GO:0043292 CC 1 contractile fiber 1 Q8WXH0,Q8NF91 280 1.28e-03 37 3 2 0.667 0.054 HP:0007340 hp 1 Lower limb muscle weakness 1 Q8WXH0,Q8NF91 280 1.36e-03 38 3 2 0.667 0.053 HP:0003691 hp 1 Scapular winging 1 Q8WXH0,Q8NF91 280 1.43e-03 39 3 2 0.667 0.051 HP:0001771 hp 1 Achilles tendon contracture 1 Q8WXH0,Q8NF91 280 1.50e-03 40 3 2 0.667 0.050 HP:0005109 hp 1 Abnormality of the Achilles tendon 1 Q8WXH0,Q8NF91 280 2.48e-03 147 3 2 0.667 0.014 GO:0031965 CC 1 nuclear membrane 1 Q8WXH0,Q8NF91 280 2.69e-03 2 3 1 0.333 0.500 GO:0031022 BP 1 nuclear migration along microfilament 1 Q8WXH0 280 2.85e-03 55 3 2 0.667 0.036 HP:0007126 hp 1 Proximal amyotrophy 1 Q8WXH0,Q8NF91 280 2.85e-03 55 3 2 0.667 0.036 HP:0002987 hp 1 Elbow flexion contracture 1 Q8WXH0,Q8NF91 280 2.96e-03 56 3 2 0.667 0.036 HP:0003325 hp 1 Limb-girdle muscle weakness 1 Q8WXH0,Q8NF91 280 3.74e-03 63 3 2 0.667 0.032 HP:0001437 hp 1 Abnormality of the musculature of the lower limbs 1 Q8WXH0,Q8NF91 280 3.80e-03 182 3 2 0.667 0.011 GO:0051235 BP 1 maintenance of location 1 Q8WXH0,Q8NF91 280 4.04e-03 3 3 1 0.333 0.333 GO:0090292 BP 1 nuclear matrix anchoring at nuclear membrane 1 Q8NF91 280 4.37e-03 195 3 2 0.667 0.010 GO:0003779 MF 1 actin binding 1 Q8WXH0,Q8NF91 280 4.49e-03 69 3 2 0.667 0.029 HP:0011006 hp 1 Abnormality of the musculature of the neck 1 Q8WXH0,Q8NF91 280 4.75e-03 71 3 2 0.667 0.028 HP:0008366 hp 1 Contractures involving the joints of the feet 1 Q8WXH0,Q8NF91 280 4.89e-03 72 3 2 0.667 0.028 HP:0005110 hp 1 Atrial fibrillation 1 Q8WXH0,Q8NF91 280 5.30e-03 75 3 2 0.667 0.027 HP:0001692 hp 1 Primary atrial arrhythmia 1 Q8WXH0,Q8NF91 280 5.38e-03 4 3 1 0.333 0.250 GO:0043578 BP 1 nuclear matrix organization 1 Q8NF91 280 5.44e-03 76 3 2 0.667 0.026 HP:0003560 hp 1 Muscular dystrophy 1 Q8WXH0,Q8NF91 280 5.44e-03 76 3 2 0.667 0.026 HP:0004755 hp 1 Supraventricular tachycardia 1 Q8WXH0,Q8NF91 280 5.59e-03 77 3 2 0.667 0.026 HP:0005115 hp 1 Supraventricular arrhythmia 1 Q8WXH0,Q8NF91 280 5.73e-03 78 3 2 0.667 0.026 HP:0001435 hp 1 Abnormality of the shoulder girdle musculature 1 Q8WXH0,Q8NF91 280 5.88e-03 79 3 2 0.667 0.025 HP:0002996 hp 1 Limited elbow movement 1 Q8WXH0,Q8NF91 280 6.82e-03 244 3 2 0.667 0.008 GO:0005635 CC 1 nuclear envelope 1 Q8WXH0,Q8NF91 280 6.97e-03 86 3 2 0.667 0.023 HP:0000782 hp 1 Abnormality of the scapula 1 Q8WXH0,Q8NF91 280 8.07e-03 6 3 1 0.333 0.167 GO:0031258 CC 1 lamellipodium membrane 1 Q8WXH0 280 8.07e-03 6 3 1 0.333 0.167 GO:0099515 BP 1 actin filament-based transport 1 Q8WXH0 280 8.15e-03 2173 3 3 1.000 0.001 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q8WXH0,P55327,Q8NF91 280 8.85e-03 97 3 2 0.667 0.021 HP:0003690 hp 1 Limb muscle weakness 1 Q8WXH0,Q8NF91 280 9.40e-03 100 3 2 0.667 0.020 HP:0002460 hp 1 Distal muscle weakness 1 Q8WXH0,Q8NF91 280 9.42e-03 7 3 1 0.333 0.143 GO:0007097 BP 1 nuclear migration 1 Q8WXH0 280 9.97e-03 103 3 2 0.667 0.019 HP:0005750 hp 1 Contractures of the joints of the lower limbs 1 Q8WXH0,Q8NF91 280 1.07e-02 107 3 2 0.667 0.019 HP:0001649 hp 1 Tachycardia 1 Q8WXH0,Q8NF91 280 1.08e-02 8 3 1 0.333 0.125 GO:0040023 BP 1 establishment of nucleus localization 1 Q8WXH0 280 1.14e-02 110 3 2 0.667 0.018 HP:0001645 hp 1 Sudden cardiac death 1 Q8WXH0,Q8NF91 280 1.17e-02 320 3 2 0.667 0.006 GO:0098590 CC 1 plasma membrane region 1 Q8WXH0,Q8NF91 280 1.17e-02 2454 3 3 1.000 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q8WXH0,P55327,Q8NF91 280 1.18e-02 112 3 2 0.667 0.018 HP:0001695 hp 1 Cardiac arrest 1 Q8WXH0,Q8NF91 280 1.22e-02 114 3 2 0.667 0.018 HP:0003677 hp 1 Slow progression 1 Q8WXH0,Q8NF91 280 1.22e-02 114 3 2 0.667 0.018 HP:0001644 hp 1 Dilated cardiomyopathy 1 Q8WXH0,Q8NF91 280 1.24e-02 115 3 2 0.667 0.017 HP:0001446 hp 1 Abnormality of the musculature of the upper limbs 1 Q8WXH0,Q8NF91 280 1.26e-02 116 3 2 0.667 0.017 HP:0003693 hp 1 Distal amyotrophy 1 Q8WXH0,Q8NF91 280 1.35e-02 10 3 1 0.333 0.100 GO:0005521 MF 1 lamin binding 1 Q8NF91 280 1.35e-02 10 3 1 0.333 0.100 GO:0051642 BP 1 centrosome localization 1 Q8WXH0 280 1.42e-02 761 3 2 0.667 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 Q8WXH0,P55327 280 1.48e-02 11 3 1 0.333 0.091 GO:0031527 CC 1 filopodium membrane 1 Q8WXH0 280 1.48e-02 11 3 1 0.333 0.091 GO:0051647 BP 1 nucleus localization 1 Q8WXH0 280 1.52e-02 1652 3 3 1.000 0.002 GO:1902578 BP 1 single-organism localization 1 Q8WXH0,P55327,Q8NF91 280 1.56e-02 798 3 2 0.667 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 Q8WXH0,P55327 280 1.75e-02 13 3 1 0.333 0.077 GO:0051457 BP 1 maintenance of protein location in nucleus 1 Q8NF91 280 1.86e-02 874 3 2 0.667 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q8WXH0,P55327 280 1.99e-02 146 3 2 0.667 0.014 HP:0011463 hp 1 Childhood onset 1 Q8WXH0,Q8NF91 280 2.13e-02 938 3 2 0.667 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q8WXH0,P55327 280 2.25e-02 445 3 2 0.667 0.004 GO:0042803 MF 1 protein homodimerization activity 1 P55327,Q8NF91 280 2.28e-02 3061 3 3 1.000 0.001 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 Q8WXH0,P55327,Q8NF91 280 2.31e-02 977 3 2 0.667 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q8WXH0,P55327 280 2.39e-02 994 3 2 0.667 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q8WXH0,P55327 280 2.56e-02 166 3 2 0.667 0.012 HP:0009811 hp 1 Abnormality of the elbow 1 Q8WXH0,Q8NF91 280 2.62e-02 3206 3 3 1.000 0.001 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 Q8WXH0,P55327,Q8NF91 280 2.66e-02 343 3 2 0.667 0.006 MI:hsa-miR-888* mi 1 MI:hsa-miR-888* 1 Q8WXH0,Q8NF91 280 2.66e-02 485 3 2 0.667 0.004 GO:0008092 MF 1 cytoskeletal protein binding 1 Q8WXH0,Q8NF91 280 2.79e-02 1078 3 2 0.667 0.002 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q8WXH0,P55327 280 2.80e-02 174 3 2 0.667 0.011 HP:0011021 hp 1 Abnormality of circulating enzyme level 1 Q8WXH0,Q8NF91 280 2.80e-02 174 3 2 0.667 0.011 HP:0040081 hp 1 Abnormal levels of creatine kinase in blood 1 Q8WXH0,Q8NF91 280 2.80e-02 174 3 2 0.667 0.011 HP:0003236 hp 1 Elevated serum creatine phosphokinase 1 Q8WXH0,Q8NF91 280 2.96e-02 22 3 1 0.333 0.045 GO:0072595 BP 1 maintenance of protein localization in organelle 1 Q8NF91 280 3.00e-02 180 3 2 0.667 0.011 HP:0003701 hp 1 Proximal muscle weakness 1 Q8WXH0,Q8NF91 280 3.07e-02 1133 3 2 0.667 0.002 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q8WXH0,P55327 280 3.08e-02 1135 3 2 0.667 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q8WXH0,P55327 280 3.12e-02 372 3 2 0.667 0.005 MI:hsa-miR-9* mi 1 MI:hsa-miR-9* 1 P55327,Q8NF91 280 3.22e-02 24 3 1 0.333 0.042 GO:0045211 CC 1 postsynaptic membrane 1 Q8NF91 280 3.50e-02 195 3 2 0.667 0.010 HP:0100360 hp 1 Contractures of the joints of the upper limbs 1 Q8WXH0,Q8NF91 280 3.54e-02 560 3 2 0.667 0.004 GO:0046983 MF 1 protein dimerization activity 1 P55327,Q8NF91 280 3.63e-02 27 3 1 0.333 0.037 GO:0016235 CC 1 aggresome 1 Q8WXH0 280 3.69e-02 1247 3 2 0.667 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q8WXH0,P55327 280 3.71e-02 406 3 2 0.667 0.005 MI:mmu-miR-680 mi 1 MI:mmu-miR-680 1 Q8WXH0,Q8NF91 280 3.89e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 Q8WXH0,P55327,Q8NF91 280 4.03e-02 30 3 1 0.333 0.033 GO:0016529 CC 1 sarcoplasmic reticulum 1 Q8WXH0 280 4.06e-02 1310 3 2 0.667 0.002 HPA:046020_03 hpa 1 tonsil; non-germinal center cells[Uncertain,High] 1 P55327,Q8NF91 280 4.16e-02 213 3 2 0.667 0.009 HP:0003581 hp 1 Adult onset 1 Q8WXH0,Q8NF91 280 4.41e-02 1369 3 2 0.667 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 Q8WXH0,Q8NF91 280 4.43e-02 33 3 1 0.333 0.030 GO:0016528 CC 1 sarcoplasm 1 Q8WXH0 280 4.51e-02 222 3 2 0.667 0.009 HP:0009127 hp 1 Abnormality of the musculature of the limbs 1 Q8WXH0,Q8NF91 280 4.55e-02 450 3 2 0.667 0.004 MI:hsa-miR-557 mi 1 MI:hsa-miR-557 1 Q8WXH0,Q8NF91 280 4.70e-02 647 3 2 0.667 0.003 GO:0042802 MF 1 identical protein binding 1 P55327,Q8NF91 280 4.75e-02 228 3 2 0.667 0.009 HP:0010876 hp 1 Abnormality of circulating protein level 1 Q8WXH0,Q8NF91 280 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q8WXH0,P55327 280 4.96e-02 665 3 2 0.667 0.003 GO:0031967 CC 1 organelle envelope 1 Q8WXH0,Q8NF91 280 5.00e-02 547 3 2 0.667 0.004 REAC:1640170 rea 1 Cell Cycle 1 Q8WXH0,Q8NF91 280 5.00e-02 1 3 1 0.333 1.000 OMIM:612998 omi 1 EMERY-DREIFUSS MUSCULAR DYSTROPHY 4, AUTOSOMAL DOMINANT; EDMD4;;EMERY-DREIFUSS MUSCULAR DYSTROPHY 4 WITH VARIABLE FEATURES 1 Q8NF91 280 5.00e-02 160 3 2 0.667 0.013 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q8WXH0,Q8NF91 280 5.00e-02 1 3 1 0.333 1.000 OMIM:612999 omi 1 EMERY-DREIFUSS MUSCULAR DYSTROPHY 5, AUTOSOMAL DOMINANT; EDMD5 1 Q8WXH0 280 5.00e-02 1 3 1 0.333 1.000 OMIM:610743 omi 1 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 8; SCAR8;;ATAXIA, RECESSIVE, OF BEAUCE;;CEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, TYPE 1; ARCA1 1 Q8NF91 280 5.00e-02 668 3 2 0.667 0.003 GO:0031975 CC 1 envelope 1 Q8WXH0,Q8NF91 280 5.00e-02 472 3 2 0.667 0.004 MI:mmu-miR-290-5p mi 1 MI:mmu-miR-290-5p 1 Q8WXH0,Q8NF91 280 5.00e-02 234 3 2 0.667 0.009 HP:0001376 hp 1 Limitation of joint mobility 1 Q8WXH0,Q8NF91 281 3.73e-03 778 2 2 1.000 0.003 TF:M07345_1 tf 1 Factor: ZNF515; motif: SCTGCTGK; match class: 1 1 Q9NPD8,Q12765 281 3.86e-03 1 2 1 0.500 1.000 OMIM:616435 omi 1 FANCONI ANEMIA, COMPLEMENTATION GROUP T; FANCT 1 Q9NPD8 281 4.67e-03 870 2 2 1.000 0.002 TF:M06686_0 tf 1 Factor: PRDM9; motif: TTTGTGGAGA; match class: 0 1 Q9NPD8,Q12765 281 5.02e-03 32 2 1 0.500 0.031 TF:M05658_0 tf 1 Factor: ZNF780A; motif: NGTGGMTTAGKC; match class: 0 1 Q9NPD8 281 5.81e-03 37 2 1 0.500 0.027 TF:M06412_0 tf 1 Factor: ZNF227; motif: NTTGMTWAAATA; match class: 0 1 Q9NPD8 281 6.43e-03 41 2 1 0.500 0.024 TF:M04380_0 tf 1 Factor: ISX; motif: NTAATCTAATTAN; match class: 0 1 Q9NPD8 281 9.88e-03 63 2 1 0.500 0.016 TF:M05323_0 tf 1 Factor: Tbx1; motif: AGGTGTGAAAG; match class: 0 1 Q9NPD8 281 9.88e-03 63 2 1 0.500 0.016 TF:M05324_0 tf 1 Factor: tbx10; motif: AGGTGTKAAAG; match class: 0 1 Q9NPD8 281 1.14e-02 1359 2 2 1.000 0.001 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q9NPD8,Q12765 281 1.34e-02 1474 2 2 1.000 0.001 TF:M01211_0 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 0 1 Q9NPD8,Q12765 281 1.38e-02 88 2 1 0.500 0.011 TF:M04120_0 tf 1 Factor: TBR1; motif: AAGGTGTGAAA; match class: 0 1 Q9NPD8 281 1.47e-02 1543 2 2 1.000 0.001 TF:M04074_0 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 0 1 Q9NPD8,Q12765 281 1.51e-02 1565 2 2 1.000 0.001 TF:M00422_1 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 1 1 Q9NPD8,Q12765 281 1.60e-02 14 2 1 0.500 0.071 HP:0003221 hp 1 Chromosomal breakage induced by crosslinking agents 1 Q9NPD8 281 1.60e-02 14 2 1 0.500 0.071 HP:0001017 hp 1 Anemic pallor 1 Q9NPD8 281 1.60e-02 14 2 1 0.500 0.071 HP:0011018 hp 1 Abnormality of the cell cycle 1 Q9NPD8 281 1.60e-02 14 2 1 0.500 0.071 HP:0003213 hp 1 Deficient excision of UV-induced pyrimidine dimers in DNA 1 Q9NPD8 281 1.60e-02 14 2 1 0.500 0.071 HP:0003214 hp 1 Prolonged G2 phase of cell cycle 1 Q9NPD8 281 1.61e-02 103 2 1 0.500 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 Q12765 281 1.71e-02 15 2 1 0.500 0.067 HP:0010293 hp 1 Aplasia/Hypoplasia of the uvula 1 Q9NPD8 281 1.72e-02 1672 2 2 1.000 0.001 TF:M04029_0 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 0 1 Q9NPD8,Q12765 281 1.83e-02 16 2 1 0.500 0.062 HP:0040012 hp 1 Chromosome breakage 1 Q9NPD8 281 1.94e-02 17 2 1 0.500 0.059 HP:0009998 hp 1 Complete duplication of phalanx of hand 1 Q9NPD8 281 1.94e-02 17 2 1 0.500 0.059 HP:0005912 hp 1 Biliary atresia 1 Q9NPD8 281 1.94e-02 17 2 1 0.500 0.059 HP:0009943 hp 1 Complete duplication of thumb phalanx 1 Q9NPD8 281 1.97e-02 126 2 1 0.500 0.008 TF:M04029_1 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 1 1 Q12765 281 2.06e-02 18 2 1 0.500 0.056 HP:0007565 hp 1 Multiple cafe-au-lait spots 1 Q9NPD8 281 2.09e-02 134 2 1 0.500 0.007 TF:M04074_1 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 1 1 Q9NPD8 281 2.15e-02 1868 2 2 1.000 0.001 TF:M01996_1 tf 1 Factor: AR; motif: GNNCNNNNTGTTCTN; match class: 1 1 Q9NPD8,Q12765 281 2.17e-02 19 2 1 0.500 0.053 HP:0001045 hp 1 Vitiligo 1 Q9NPD8 281 2.17e-02 19 2 1 0.500 0.053 HP:0000081 hp 1 Duplicated collecting system 1 Q9NPD8 281 2.19e-02 1882 2 2 1.000 0.001 TF:M01058_0 tf 1 Factor: Gfi1b; motif: TAAATCACTGCW; match class: 0 1 Q9NPD8,Q12765 281 2.28e-02 20 2 1 0.500 0.050 HP:0004353 hp 1 Abnormality of pyrimidine metabolism 1 Q9NPD8 281 2.28e-02 20 2 1 0.500 0.050 HP:0100760 hp 1 Clubbing of toes 1 Q9NPD8 281 2.28e-02 20 2 1 0.500 0.050 HP:0002245 hp 1 Meckel diverticulum 1 Q9NPD8 281 2.34e-02 150 2 1 0.500 0.007 TF:M00292_1 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 1 1 Q12765 281 2.40e-02 21 2 1 0.500 0.048 HP:0004742 hp 1 Abnormality of the renal collecting system 1 Q9NPD8 281 2.40e-02 21 2 1 0.500 0.048 HP:0003254 hp 1 Abnormality of DNA repair 1 Q9NPD8 281 2.44e-02 156 2 1 0.500 0.006 TF:M04515_0 tf 1 Factor: E2F1; motif: WWTGGCGCCAAA; match class: 0 1 Q12765 281 2.44e-02 156 2 1 0.500 0.006 TF:M00113_1 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 1 1 Q9NPD8 281 2.51e-02 22 2 1 0.500 0.045 HP:0001549 hp 1 Abnormality of the ileum 1 Q9NPD8 281 2.52e-02 2022 2 2 1.000 0.001 TF:M00141_0 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 0 1 Q9NPD8,Q12765 281 2.62e-02 23 2 1 0.500 0.043 HP:0010932 hp 1 Abnormality of nucleobase metabolism 1 Q9NPD8 281 2.62e-02 23 2 1 0.500 0.043 HP:0002032 hp 1 Esophageal atresia 1 Q9NPD8 281 2.71e-02 2096 2 2 1.000 0.001 TF:M00053_0 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 0 1 Q9NPD8,Q12765 281 2.85e-02 25 2 1 0.500 0.040 HP:0005344 hp 1 Abnormality of the carotid arteries 1 Q9NPD8 281 2.96e-02 26 2 1 0.500 0.038 HP:0000073 hp 1 Ureteral duplication 1 Q9NPD8 281 2.98e-02 191 2 1 0.500 0.005 TF:M07217_0 tf 1 Factor: MAX; motif: RRGCACATGK; match class: 0 1 Q9NPD8 281 3.03e-02 194 2 1 0.500 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 Q9NPD8 281 3.08e-02 27 2 1 0.500 0.037 HP:0002885 hp 1 Medulloblastoma 1 Q9NPD8 281 3.14e-02 2255 2 2 1.000 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 Q9NPD8,Q12765 281 3.19e-02 28 2 1 0.500 0.036 HP:0003953 hp 1 Absent forearm bone 1 Q9NPD8 281 3.19e-02 28 2 1 0.500 0.036 HP:0003974 hp 1 Absent radius 1 Q9NPD8 281 3.19e-02 28 2 1 0.500 0.036 HP:0009822 hp 1 Aplasia involving forearm bones 1 Q9NPD8 281 3.33e-02 2323 2 2 1.000 0.001 TF:M00930_0 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 0 1 Q9NPD8,Q12765 281 3.37e-02 2337 2 2 1.000 0.001 TF:M04414_0 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 0 1 Q9NPD8,Q12765 281 3.41e-02 219 2 1 0.500 0.005 TF:M04011_1 tf 1 Factor: HSFY1; motif: TTCGAANNRTTCGAA; match class: 1 1 Q12765 281 3.42e-02 30 2 1 0.500 0.033 HP:0000125 hp 1 Pelvic kidney 1 Q9NPD8 281 3.42e-02 30 2 1 0.500 0.033 HP:0100867 hp 1 Duodenal stenosis 1 Q9NPD8 281 3.42e-02 30 2 1 0.500 0.033 HP:0001896 hp 1 Reticulocytopenia 1 Q9NPD8 281 3.42e-02 30 2 1 0.500 0.033 HP:0012848 hp 1 Small intestinal stenosis 1 Q9NPD8 281 3.42e-02 30 2 1 0.500 0.033 HP:0100587 hp 1 Abnormality of the preputium 1 Q9NPD8 281 3.64e-02 32 2 1 0.500 0.031 HP:0001915 hp 1 Aplastic anemia 1 Q9NPD8 281 3.64e-02 32 2 1 0.500 0.031 HP:0003220 hp 1 Abnormality of chromosome stability 1 Q9NPD8 281 3.76e-02 33 2 1 0.500 0.030 HP:0002667 hp 1 Nephroblastoma 1 Q9NPD8 281 3.87e-02 34 2 1 0.500 0.029 HP:0011794 hp 1 Embryonal renal neoplasm 1 Q9NPD8 281 3.94e-02 253 2 1 0.500 0.004 TF:M01044_0 tf 1 Factor: Tbx5; motif: CTCACACCTT; match class: 0 1 Q9NPD8 281 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q9NPD8 281 3.98e-02 35 2 1 0.500 0.029 HP:0009777 hp 1 Absent thumb 1 Q9NPD8 281 3.98e-02 35 2 1 0.500 0.029 HP:0002589 hp 1 Gastrointestinal atresia 1 Q9NPD8 281 4.00e-02 4 2 1 0.500 0.250 GO:0044314 BP 1 protein K27-linked ubiquitination 1 Q9NPD8 281 4.10e-02 2578 2 2 1.000 0.001 TF:M02088_0 tf 1 Factor: E2A; motif: NRMCASCTGCNNN; match class: 0 1 Q9NPD8,Q12765 281 4.24e-02 2622 2 2 1.000 0.001 TF:M04072_0 tf 1 Factor: POU2F2; motif: NTATGCWAATN; match class: 0 1 Q9NPD8,Q12765 281 4.25e-02 2624 2 2 1.000 0.001 TF:M04088_0 tf 1 Factor: POU5F1B; motif: TATGCWAAT; match class: 0 1 Q9NPD8,Q12765 281 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 Q9NPD8 281 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 Q9NPD8 281 4.44e-02 39 2 1 0.500 0.026 HP:0100026 hp 1 Arteriovenous malformation 1 Q9NPD8 281 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 Q9NPD8 281 4.52e-02 291 2 1 0.500 0.003 TF:M07258_1 tf 1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 1 1 Q9NPD8 281 4.52e-02 2707 2 2 1.000 0.001 TF:M03837_0 tf 1 Factor: Oct3; motif: TKWNATGCAWATN; match class: 0 1 Q9NPD8,Q12765 281 4.55e-02 2714 2 2 1.000 0.001 TF:M04413_0 tf 1 Factor: NKX3-1; motif: NCCACTTAA; match class: 0 1 Q9NPD8,Q12765 281 4.64e-02 299 2 1 0.500 0.003 TF:M05619_0 tf 1 Factor: ZSCAN5C; motif: NMGTTWAACATG; match class: 0 1 Q12765 281 4.66e-02 41 2 1 0.500 0.024 HP:0002898 hp 1 Embryonal neoplasm 1 Q9NPD8 281 4.66e-02 41 2 1 0.500 0.024 HP:0009942 hp 1 Duplication of thumb phalanx 1 Q9NPD8 281 4.67e-02 301 2 1 0.500 0.003 TF:M04134_1 tf 1 Factor: TBX2; motif: NAGGTGTGAAN; match class: 1 1 Q9NPD8 281 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q9NPD8 281 4.89e-02 43 2 1 0.500 0.023 HP:0002860 hp 1 Squamous cell carcinoma 1 Q9NPD8 281 4.95e-02 319 2 1 0.500 0.003 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q12765 281 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q9NPD8 281 5.00e-02 29 2 1 0.500 0.034 REAC:6783310 rea 1 Fanconi Anemia Pathway 1 Q9NPD8 281 5.00e-02 5 2 1 0.500 0.200 GO:0035519 BP 1 protein K29-linked ubiquitination 1 Q9NPD8 281 5.00e-02 45 2 1 0.500 0.022 KEGG:03460 keg 1 Fanconi anemia pathway 1 Q9NPD8 281 5.00e-02 44 2 1 0.500 0.023 HP:0000815 hp 1 Hypergonadotropic hypogonadism 1 Q9NPD8 282 3.40e-07 5 2 2 1.000 0.400 GO:0004849 MF 1 uridine kinase activity 1 Q96BW1,Q9HA47 282 1.87e-06 11 2 2 1.000 0.182 GO:0006206 BP 1 pyrimidine nucleobase metabolic process 1 Q96BW1,Q9HA47 282 2.25e-06 12 2 2 1.000 0.167 GO:0008655 BP 1 pyrimidine-containing compound salvage 1 Q96BW1,Q9HA47 282 2.25e-06 12 2 2 1.000 0.167 GO:0043097 BP 1 pyrimidine nucleoside salvage 1 Q96BW1,Q9HA47 282 3.10e-06 14 2 2 1.000 0.143 GO:0043174 BP 1 nucleoside salvage 1 Q96BW1,Q9HA47 282 3.10e-06 14 2 2 1.000 0.143 GO:0019206 MF 1 nucleoside kinase activity 1 Q96BW1,Q9HA47 282 6.46e-06 20 2 2 1.000 0.100 GO:0046134 BP 1 pyrimidine nucleoside biosynthetic process 1 Q96BW1,Q9HA47 282 9.39e-06 24 2 2 1.000 0.083 GO:0009112 BP 1 nucleobase metabolic process 1 Q96BW1,Q9HA47 282 1.11e-05 26 2 2 1.000 0.077 GO:0072528 BP 1 pyrimidine-containing compound biosynthetic process 1 Q96BW1,Q9HA47 282 1.58e-05 31 2 2 1.000 0.065 GO:0006213 BP 1 pyrimidine nucleoside metabolic process 1 Q96BW1,Q9HA47 282 2.14e-05 36 2 2 1.000 0.056 GO:0043094 BP 1 cellular metabolic compound salvage 1 Q96BW1,Q9HA47 282 3.22e-05 44 2 2 1.000 0.045 GO:0019205 MF 1 nucleobase-containing compound kinase activity 1 Q96BW1,Q9HA47 282 5.05e-05 55 2 2 1.000 0.036 GO:0072527 BP 1 pyrimidine-containing compound metabolic process 1 Q96BW1,Q9HA47 282 1.16e-04 83 2 2 1.000 0.024 GO:0009163 BP 1 nucleoside biosynthetic process 1 Q96BW1,Q9HA47 282 1.21e-04 85 2 2 1.000 0.024 GO:1901659 BP 1 glycosyl compound biosynthetic process 1 Q96BW1,Q9HA47 282 4.07e-04 95 2 2 1.000 0.021 KEGG:00240 keg 1 Pyrimidine metabolism 1 Q96BW1,Q9HA47 282 1.34e-03 281 2 2 1.000 0.007 GO:0009116 BP 1 nucleoside metabolic process 1 Q96BW1,Q9HA47 282 1.52e-03 299 2 2 1.000 0.007 GO:1901657 BP 1 glycosyl compound metabolic process 1 Q96BW1,Q9HA47 282 3.44e-03 450 2 2 1.000 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 Q96BW1,Q9HA47 282 3.69e-03 466 2 2 1.000 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q96BW1,Q9HA47 282 5.65e-03 10 2 1 0.500 0.100 REAC:73614 rea 1 Pyrimidine salvage reactions 1 Q9HA47 282 6.74e-03 630 2 2 1.000 0.003 GO:0016301 MF 1 kinase activity 1 Q96BW1,Q9HA47 282 9.68e-03 755 2 2 1.000 0.003 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q96BW1,Q9HA47 282 1.08e-02 798 2 2 1.000 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q96BW1,Q9HA47 282 1.23e-02 851 2 2 1.000 0.002 GO:0044711 BP 1 single-organism biosynthetic process 1 Q96BW1,Q9HA47 282 1.35e-02 24 2 1 0.500 0.042 REAC:73848 rea 1 Pyrimidine metabolism 1 Q9HA47 282 1.58e-02 965 2 2 1.000 0.002 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q96BW1,Q9HA47 282 1.61e-02 35 2 1 0.500 0.029 KEGG:00983 keg 1 Drug metabolism - other enzymes 1 Q9HA47 282 3.02e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 Q96BW1,Q9HA47 282 3.23e-02 1941 2 2 1.000 0.001 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q96BW1,Q9HA47 282 4.16e-02 1565 2 2 1.000 0.001 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q96BW1,Q9HA47 282 4.55e-02 258 2 1 0.500 0.004 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 Q9HA47 282 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 Q96BW1,Q9HA47 282 5.00e-02 89 2 1 0.500 0.011 REAC:15869 rea 1 Metabolism of nucleotides 1 Q9HA47 282 5.00e-02 3 2 1 0.500 0.333 TF:M06135_1 tf 1 Factor: ZNF28; motif: GCKAAAGGAWA; match class: 1 1 Q96BW1 282 5.00e-02 1715 2 2 1.000 0.001 GO:0016740 MF 1 transferase activity 1 Q96BW1,Q9HA47 283 4.37e-04 1 2 1 0.500 1.000 GO:0044867 BP 1 modulation by host of viral catalytic activity 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:0052403 BP 1 negative regulation by host of symbiont catalytic activity 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:1903016 BP 1 negative regulation of exo-alpha-sialidase activity 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:1903015 BP 1 regulation of exo-alpha-sialidase activity 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:0044870 BP 1 modulation by host of viral glycoprotein metabolic process 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:0044871 BP 1 negative regulation by host of viral glycoprotein metabolic process 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:0044866 BP 1 modulation by host of viral exo-alpha-sialidase activity 1 P26022 283 4.37e-04 1 2 1 0.500 1.000 GO:0044869 BP 1 negative regulation by host of viral exo-alpha-sialidase activity 1 P26022 283 8.74e-04 2 2 1 0.500 0.500 GO:0044868 BP 1 modulation by host of viral molecular function 1 P26022 283 8.74e-04 2 2 1 0.500 0.500 GO:0052199 BP 1 negative regulation of catalytic activity in other organism involved in symbiotic interaction 1 P26022 283 1.31e-03 3 2 1 0.500 0.333 GO:0052055 BP 1 modulation by symbiont of host molecular function 1 P26022 283 1.31e-03 3 2 1 0.500 0.333 GO:0052203 BP 1 modulation of catalytic activity in other organism involved in symbiotic interaction 1 P26022 283 1.31e-03 3 2 1 0.500 0.333 GO:0052405 BP 1 negative regulation by host of symbiont molecular function 1 P26022 283 1.31e-03 3 2 1 0.500 0.333 GO:0052422 BP 1 modulation by host of symbiont catalytic activity 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0001849 MF 1 complement component C1q binding 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0044362 BP 1 negative regulation of molecular function in other organism 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0044359 BP 1 modulation of molecular function in other organism 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0052204 BP 1 negative regulation of molecular function in other organism involved in symbiotic interaction 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0052428 BP 1 modification by host of symbiont molecular function 1 P26022 283 1.75e-03 4 2 1 0.500 0.250 GO:0052205 BP 1 modulation of molecular function in other organism involved in symbiotic interaction 1 P26022 283 2.62e-03 6 2 1 0.500 0.167 GO:0001846 MF 1 opsonin binding 1 P26022 283 3.06e-03 7 2 1 0.500 0.143 GO:0046790 MF 1 virion binding 1 P26022 283 3.06e-03 7 2 1 0.500 0.143 GO:0044793 BP 1 negative regulation by host of viral process 1 P26022 283 3.49e-03 8 2 1 0.500 0.125 GO:0005537 MF 1 mannose binding 1 Q9Y6Z7 283 3.93e-03 9 2 1 0.500 0.111 GO:0001848 MF 1 complement binding 1 P26022 283 4.08e-03 12 2 1 0.500 0.083 REAC:166663 rea 1 Initial triggering of complement 1 Q9Y6Z7 283 4.37e-03 10 2 1 0.500 0.100 GO:1903019 BP 1 negative regulation of glycoprotein metabolic process 1 P26022 283 4.80e-03 11 2 1 0.500 0.091 GO:0046597 BP 1 negative regulation of viral entry into host cell 1 P26022 283 4.93e-03 894 2 2 1.000 0.002 TF:M07218_0 tf 1 Factor: MEF-2A; motif: NKCTAAAAATAGMNN; match class: 0 1 P26022,Q9Y6Z7 283 6.11e-03 14 2 1 0.500 0.071 GO:0044788 BP 1 modulation by host of viral process 1 P26022 283 7.48e-03 22 2 1 0.500 0.045 REAC:166658 rea 1 Complement cascade 1 Q9Y6Z7 283 8.30e-03 19 2 1 0.500 0.053 GO:0046596 BP 1 regulation of viral entry into host cell 1 P26022 283 9.25e-03 59 2 1 0.500 0.017 TF:M06569_0 tf 1 Factor: ZNF775; motif: NYGGGAAAATW; match class: 0 1 P26022 283 9.88e-03 63 2 1 0.500 0.016 TF:M06769_0 tf 1 Factor: ZNF391; motif: NGGGCSAGCMGA; match class: 0 1 Q9Y6Z7 283 1.00e-02 23 2 1 0.500 0.043 GO:0048029 MF 1 monosaccharide binding 1 Q9Y6Z7 283 1.03e-02 739 2 2 1.000 0.003 GO:0006955 BP 1 immune response 1 P26022,Q9Y6Z7 283 1.09e-02 25 2 1 0.500 0.040 GO:1903018 BP 1 regulation of glycoprotein metabolic process 1 P26022 283 1.29e-02 1446 2 2 1.000 0.001 TF:M07327_1 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 1 1 P26022,Q9Y6Z7 283 1.40e-02 32 2 1 0.500 0.031 GO:0006956 BP 1 complement activation 1 Q9Y6Z7 283 1.46e-02 93 2 1 0.500 0.011 TF:M01235_0 tf 1 Factor: ipf1; motif: NVSTAATTAC; match class: 0 1 Q9Y6Z7 283 1.50e-02 1557 2 2 1.000 0.001 TF:M07044_1 tf 1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 1 P26022,Q9Y6Z7 283 1.52e-02 1569 2 2 1.000 0.001 TF:M01233_0 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 0 1 P26022,Q9Y6Z7 283 1.53e-02 35 2 1 0.500 0.029 GO:0051851 BP 1 modification by host of symbiont morphology or physiology 1 P26022 283 1.57e-02 36 2 1 0.500 0.028 GO:0044003 BP 1 modification by symbiont of host morphology or physiology 1 P26022 283 1.57e-02 36 2 1 0.500 0.028 GO:0046718 BP 1 viral entry into host cell 1 P26022 283 1.57e-02 36 2 1 0.500 0.028 GO:0051702 BP 1 interaction with symbiont 1 P26022 283 1.70e-02 39 2 1 0.500 0.026 GO:0051806 BP 1 entry into cell of other organism involved in symbiotic interaction 1 P26022 283 1.70e-02 39 2 1 0.500 0.026 GO:0030260 BP 1 entry into host cell 1 P26022 283 1.70e-02 39 2 1 0.500 0.026 GO:0044409 BP 1 entry into host 1 P26022 283 1.70e-02 39 2 1 0.500 0.026 GO:0051828 BP 1 entry into other organism involved in symbiotic interaction 1 P26022 283 1.88e-02 120 2 1 0.500 0.008 TF:M04108_1 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 1 1 P26022 283 2.04e-02 1818 2 2 1.000 0.001 TF:M04407_0 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 0 1 P26022,Q9Y6Z7 283 2.05e-02 131 2 1 0.500 0.008 TF:M05419_0 tf 1 Factor: ZNF499; motif: NGTTCCGGASGC; match class: 0 1 Q9Y6Z7 283 2.07e-02 938 2 2 1.000 0.002 REAC:168249 rea 1 Innate Immune System 1 P26022,Q9Y6Z7 283 2.09e-02 48 2 1 0.500 0.021 GO:0072376 BP 1 protein activation cascade 1 Q9Y6Z7 283 2.10e-02 1847 2 2 1.000 0.001 TF:M01872_1 tf 1 Factor: DBP; motif: TTWTGYAA; match class: 1 1 P26022,Q9Y6Z7 283 2.19e-02 1882 2 2 1.000 0.001 TF:M01058_0 tf 1 Factor: Gfi1b; motif: TAAATCACTGCW; match class: 0 1 P26022,Q9Y6Z7 283 2.27e-02 1916 2 2 1.000 0.001 TF:M04319_1 tf 1 Factor: ESX1; motif: NNYAATTANN; match class: 1 1 P26022,Q9Y6Z7 283 2.27e-02 52 2 1 0.500 0.019 GO:0030246 MF 1 carbohydrate binding 1 Q9Y6Z7 283 2.53e-02 162 2 1 0.500 0.006 TF:M04018_0 tf 1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 0 1 P26022 283 2.57e-02 1165 2 2 1.000 0.002 GO:0002376 BP 1 immune system process 1 P26022,Q9Y6Z7 283 2.57e-02 59 2 1 0.500 0.017 GO:1903901 BP 1 negative regulation of viral life cycle 1 P26022 283 2.66e-02 61 2 1 0.500 0.016 GO:0048525 BP 1 negative regulation of viral process 1 P26022 283 2.75e-02 63 2 1 0.500 0.016 GO:0051817 BP 1 modification of morphology or physiology of other organism involved in symbiotic interaction 1 P26022 283 2.78e-02 178 2 1 0.500 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 Q9Y6Z7 283 2.87e-02 184 2 1 0.500 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 P26022 283 2.88e-02 66 2 1 0.500 0.015 GO:0035821 BP 1 modification of morphology or physiology of other organism 1 P26022 283 2.92e-02 67 2 1 0.500 0.015 GO:0043901 BP 1 negative regulation of multi-organism process 1 P26022 283 3.15e-02 202 2 1 0.500 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 P26022 283 3.20e-02 2278 2 2 1.000 0.001 TF:M04240_0 tf 1 Factor: FOXD3; motif: NRNWAATATTKACN; match class: 0 1 P26022,Q9Y6Z7 283 3.21e-02 206 2 1 0.500 0.005 TF:M00736_1 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 1 P26022 283 3.27e-02 210 2 1 0.500 0.005 TF:M01117_1 tf 1 Factor: OTX; motif: GATTANNT; match class: 1 1 P26022 283 3.31e-02 76 2 1 0.500 0.013 GO:0006959 BP 1 humoral immune response 1 Q9Y6Z7 283 3.58e-02 2410 2 2 1.000 0.001 TF:M03829_0 tf 1 Factor: HNF-6; motif: AATCAATA; match class: 0 1 P26022,Q9Y6Z7 283 3.79e-02 87 2 1 0.500 0.011 GO:0004252 MF 1 serine-type endopeptidase activity 1 Q9Y6Z7 283 3.82e-02 2489 2 2 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 P26022,Q9Y6Z7 283 4.26e-02 2628 2 2 1.000 0.001 TF:M04393_1 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 1 1 P26022,Q9Y6Z7 283 4.26e-02 98 2 1 0.500 0.010 GO:0051701 BP 1 interaction with host 1 P26022 283 4.31e-02 277 2 1 0.500 0.004 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q9Y6Z7 283 4.34e-02 279 2 1 0.500 0.004 TF:M04290_0 tf 1 Factor: BARX1; motif: CNATTAAAWANCNATTA; match class: 0 1 Q9Y6Z7 283 4.36e-02 2657 2 2 1.000 0.001 TF:M00132_0 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 0 1 P26022,Q9Y6Z7 283 4.49e-02 2697 2 2 1.000 0.001 TF:M07046_0 tf 1 Factor: LEF-1; motif: ANNWWCAAAGN; match class: 0 1 P26022,Q9Y6Z7 283 4.75e-02 306 2 1 0.500 0.003 TF:M03874_0 tf 1 Factor: Hoxa9; motif: ATYAATDACATC; match class: 0 1 Q9Y6Z7 283 4.77e-02 2781 2 2 1.000 0.001 TF:M07421_1 tf 1 Factor: HOXC-8; motif: GAATWAYARN; match class: 1 1 P26022,Q9Y6Z7 283 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 P26022 283 4.95e-02 319 2 1 0.500 0.003 TF:M01022_1 tf 1 Factor: LEF-1; motif: NWTCAAAGNN; match class: 1 1 Q9Y6Z7 283 4.97e-02 2837 2 2 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 P26022,Q9Y6Z7 283 4.97e-02 2837 2 2 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 P26022,Q9Y6Z7 283 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 P26022 283 5.00e-02 2846 2 2 1.000 0.001 TF:M04392_1 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 1 1 P26022,Q9Y6Z7 283 5.00e-02 290 2 2 1.000 0.007 MI:hsa-miR-132* mi 1 MI:hsa-miR-132* 1 P26022,Q9Y6Z7 283 5.00e-02 1457 2 2 1.000 0.001 REAC:168256 rea 1 Immune System 1 P26022,Q9Y6Z7 283 5.00e-02 115 2 1 0.500 0.009 GO:0008236 MF 1 serine-type peptidase activity 1 Q9Y6Z7 284 9.14e-06 645 8 6 0.750 0.009 GO:0005730 CC 1 nucleolus 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q9Y3T9 284 3.32e-04 1960 8 7 0.875 0.004 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 3.32e-04 1960 8 7 0.875 0.004 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 1.68e-03 449 8 4 0.500 0.009 GO:0006325 BP 1 chromatin organization 1 P46013,Q7Z7K6,Q9H6W3,Q9Y3T9 284 4.45e-03 1118 8 5 0.625 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 Q9H6R0,O00567,O60287,P46013,Q9Y3T9 284 5.10e-03 2931 8 7 0.875 0.002 GO:0031981 CC 1 nuclear lumen 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 5.67e-03 4430 8 8 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9H6W3,Q9Y3T9 284 8.35e-03 1 8 1 0.125 1.000 GO:0030690 CC 1 Noc1p-Noc2p complex 1 Q9Y3T9 284 8.35e-03 1 8 1 0.125 1.000 GO:0030691 CC 1 Noc2p-Noc3p complex 1 Q9Y3T9 284 8.53e-03 278 8 3 0.375 0.011 GO:0042254 BP 1 ribosome biogenesis 1 O00567,Q9H6W3,Q9Y3T9 284 8.58e-03 3168 8 7 0.875 0.002 GO:0044428 CC 1 nuclear part 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 1.03e-02 1336 8 5 0.625 0.004 GO:0003723 MF 1 RNA binding 1 Q9H6R0,O00567,O60287,P46013,Q9Y3T9 284 1.16e-02 69 8 2 0.250 0.029 GO:0030684 CC 1 preribosome 1 O00567,Q9Y3T9 284 1.67e-02 2 8 1 0.125 0.500 GO:0031508 BP 1 pericentric heterochromatin assembly 1 Q7Z7K6 284 1.70e-02 798 8 3 0.375 0.004 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 O00567,O60287,Q7Z7K6 284 1.76e-02 85 8 2 0.250 0.024 GO:0031497 BP 1 chromatin assembly 1 Q7Z7K6,Q9Y3T9 284 1.83e-02 303 8 2 0.250 0.007 MI:hsa-miR-593* mi 1 MI:hsa-miR-593* 1 Q7Z7K6,Q9Y3T9 284 1.87e-02 3561 8 7 0.875 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 1.87e-02 3561 8 7 0.875 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 1.87e-02 3561 8 7 0.875 0.002 GO:0043233 CC 1 organelle lumen 1 Q9H6R0,O00567,Q14146,O60287,P46013,Q7Z7K6,Q9Y3T9 284 2.15e-02 871 8 3 0.375 0.003 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 O00567,O60287,Q7Z7K6 284 2.28e-02 97 8 2 0.250 0.021 GO:1902275 BP 1 regulation of chromatin organization 1 P46013,Q9Y3T9 284 2.34e-02 394 8 3 0.375 0.008 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 O00567,Q9H6W3,Q9Y3T9 284 2.50e-02 3 8 1 0.125 0.333 GO:1990226 MF 1 histone methyltransferase binding 1 O00567 284 2.50e-02 3 8 1 0.125 0.333 GO:0032066 BP 1 nucleolus to nucleoplasm transport 1 Q9Y3T9 284 2.50e-02 3 8 1 0.125 0.333 GO:0030689 CC 1 Noc complex 1 Q9Y3T9 284 2.52e-02 102 8 2 0.250 0.020 GO:0006333 BP 1 chromatin assembly or disassembly 1 Q7Z7K6,Q9Y3T9 284 2.65e-02 9 8 1 0.125 0.111 HP:0012473 hp 1 Tongue atrophy 1 O00567 284 2.68e-02 371 8 2 0.250 0.005 MI:hsa-miR-653 mi 1 MI:hsa-miR-653 1 Q14146,Q7Z7K6 284 2.86e-02 969 8 3 0.375 0.003 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 O00567,O60287,Q7Z7K6 284 2.92e-02 110 8 2 0.250 0.018 GO:0006323 BP 1 DNA packaging 1 Q7Z7K6,Q9Y3T9 284 3.19e-02 115 8 2 0.250 0.017 GO:0006338 BP 1 chromatin remodeling 1 Q7Z7K6,Q9H6W3 284 3.34e-02 4 8 1 0.125 0.250 GO:0070544 BP 1 histone H3-K36 demethylation 1 Q9H6W3 284 3.34e-02 4 8 1 0.125 0.250 GO:0051864 MF 1 histone demethylase activity (H3-K36 specific) 1 Q9H6W3 284 3.34e-02 417 8 2 0.250 0.005 MI:hsa-miR-328 mi 1 MI:hsa-miR-328 1 Q7Z7K6,Q9Y3T9 284 3.41e-02 1857 8 4 0.500 0.002 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 O00567,O60287,P46013,Q7Z7K6 284 3.44e-02 424 8 2 0.250 0.005 MI:hsa-miR-138 mi 1 MI:hsa-miR-138 1 O60287,Q7Z7K6 284 3.50e-02 428 8 2 0.250 0.005 MI:hsa-miR-193b mi 1 MI:hsa-miR-193b 1 Q7Z7K6,Q9Y3T9 284 3.64e-02 437 8 2 0.250 0.005 MI:hsa-miR-217 mi 1 MI:hsa-miR-217 1 Q14146,Q7Z7K6 284 3.81e-02 448 8 2 0.250 0.004 MI:hsa-miR-564 mi 1 MI:hsa-miR-564 1 O00567,Q7Z7K6 284 3.90e-02 1933 8 4 0.500 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 O00567,O60287,P46013,Q7Z7K6 284 3.92e-02 455 8 2 0.250 0.004 MI:mmu-miR-714 mi 1 MI:mmu-miR-714 1 Q14146,Q9Y3T9 284 3.99e-02 1100 8 3 0.375 0.003 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 O00567,O60287,Q7Z7K6 284 4.00e-02 460 8 2 0.250 0.004 MI:hsa-miR-674 mi 1 MI:hsa-miR-674 1 Q14146,Q7Z7K6 284 4.03e-02 37 8 1 0.125 0.027 REAC:390471 rea 1 Association of TriC/CCT with target proteins during biosynthesis 1 O00567 284 4.17e-02 5 8 1 0.125 0.200 GO:0031428 CC 1 box C/D snoRNP complex 1 O00567 284 4.27e-02 1986 8 4 0.500 0.002 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 O00567,O60287,P46013,Q7Z7K6 284 4.34e-02 1996 8 4 0.500 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 O00567,O60287,P46013,Q7Z7K6 284 4.46e-02 2013 8 4 0.500 0.002 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 O00567,Q14146,O60287,Q7Z7K6 284 4.69e-02 484 8 2 0.250 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 O60287,Q7Z7K6 284 4.75e-02 2051 8 4 0.500 0.002 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 O00567,O60287,P46013,Q7Z7K6 284 5.00e-02 6 8 1 0.125 0.167 GO:0070761 CC 1 pre-snoRNP complex 1 O00567 284 5.00e-02 6 8 1 0.125 0.167 GO:0032453 MF 1 histone demethylase activity (H3-K4 specific) 1 Q9H6W3 284 5.00e-02 6 8 1 0.125 0.167 GO:0034720 BP 1 histone H3-K4 demethylation 1 Q9H6W3 284 5.00e-02 1 8 1 0.125 1.000 OMIM:614153 omi 1 SPINOCEREBELLAR ATAXIA 36; SCA36 1 O00567 284 5.00e-02 1138 8 5 0.625 0.004 TF:M01593_1 tf 1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 1 1 O00567,Q14146,P46013,Q7Z7K6,Q9Y3T9 285 3.12e-11 25 4 4 1.000 0.160 GO:0050690 BP 1 regulation of defense response to virus by virus 1 Q9BXS5,Q10567,P61966,O43747 285 5.62e-11 10 4 4 1.000 0.400 REAC:164940 rea 1 Nef mediated downregulation of MHC class I complex cell surface expression 1 Q9BXS5,Q10567,P61966,O43747 285 1.82e-10 38 4 4 1.000 0.105 GO:0030669 CC 1 clathrin-coated endocytic vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 4.03e-10 46 4 4 1.000 0.087 GO:0045334 CC 1 clathrin-coated endocytic vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 5.78e-10 8 4 4 1.000 0.500 CORUM:36 cor 1 AP1 adaptor complex 1 Q9BXS5,Q10567,P61966,O43747 285 7.81e-10 54 4 4 1.000 0.074 GO:0030665 CC 1 clathrin-coated vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 8.18e-10 18 4 4 1.000 0.222 REAC:164938 rea 1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1 Q9BXS5,Q10567,P61966,O43747 285 1.04e-09 9 4 4 1.000 0.444 CORUM:144 cor 1 Gamma-BAR-AP1 complex 1 Q9BXS5,Q10567,P61966,O43747 285 1.05e-09 58 4 4 1.000 0.069 GO:0050688 BP 1 regulation of defense response to virus 1 Q9BXS5,Q10567,P61966,O43747 285 2.40e-09 71 4 4 1.000 0.056 GO:0032588 CC 1 trans-Golgi network membrane 1 Q9BXS5,Q10567,P61966,O43747 285 3.38e-09 25 4 4 1.000 0.160 REAC:164952 rea 1 The role of Nef in HIV-1 replication and disease pathogenesis 1 Q9BXS5,Q10567,P61966,O43747 285 3.91e-09 80 4 4 1.000 0.050 GO:0002831 BP 1 regulation of response to biotic stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 4.11e-09 81 4 4 1.000 0.049 GO:0019886 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class II 1 Q9BXS5,Q10567,P61966,O43747 285 4.32e-09 82 4 4 1.000 0.049 GO:0002495 BP 1 antigen processing and presentation of peptide antigen via MHC class II 1 Q9BXS5,Q10567,P61966,O43747 285 4.54e-09 83 4 4 1.000 0.048 GO:0002504 BP 1 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1 Q9BXS5,Q10567,P61966,O43747 285 8.56e-09 97 4 4 1.000 0.041 GO:0030662 CC 1 coated vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 8.56e-09 97 4 4 1.000 0.041 GO:0030666 CC 1 endocytic vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 9.30e-09 99 4 4 1.000 0.040 GO:0030136 CC 1 clathrin-coated vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 9.68e-09 100 4 4 1.000 0.040 GO:0051607 BP 1 defense response to virus 1 Q9BXS5,Q10567,P61966,O43747 285 1.40e-08 35 4 4 1.000 0.114 REAC:432720 rea 1 Lysosome Vesicle Biogenesis 1 Q9BXS5,Q10567,P61966,O43747 285 4.13e-08 143 4 4 1.000 0.028 GO:0002478 BP 1 antigen processing and presentation of exogenous peptide antigen 1 Q9BXS5,Q10567,P61966,O43747 285 4.24e-08 144 4 4 1.000 0.028 GO:0019884 BP 1 antigen processing and presentation of exogenous antigen 1 Q9BXS5,Q10567,P61966,O43747 285 4.61e-08 147 4 4 1.000 0.027 GO:0005802 CC 1 trans-Golgi network 1 Q9BXS5,Q10567,P61966,O43747 285 5.00e-08 150 4 4 1.000 0.027 GO:0048002 BP 1 antigen processing and presentation of peptide antigen 1 Q9BXS5,Q10567,P61966,O43747 285 5.42e-08 153 4 4 1.000 0.026 GO:0009615 BP 1 response to virus 1 Q9BXS5,Q10567,P61966,O43747 285 5.71e-08 155 4 4 1.000 0.026 GO:0002697 BP 1 regulation of immune effector process 1 Q9BXS5,Q10567,P61966,O43747 285 6.49e-08 160 4 4 1.000 0.025 GO:0030135 CC 1 coated vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 7.91e-08 168 4 4 1.000 0.024 GO:0098542 BP 1 defense response to other organism 1 Q9BXS5,Q10567,P61966,O43747 285 8.10e-08 169 4 4 1.000 0.024 GO:0098791 CC 1 Golgi subcompartment 1 Q9BXS5,Q10567,P61966,O43747 285 8.90e-08 173 4 4 1.000 0.023 GO:0019882 BP 1 antigen processing and presentation 1 Q9BXS5,Q10567,P61966,O43747 285 9.82e-08 56 4 4 1.000 0.071 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 Q9BXS5,Q10567,P61966,O43747 285 1.07e-07 181 4 4 1.000 0.022 GO:0030139 CC 1 endocytic vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 1.09e-07 182 4 4 1.000 0.022 GO:0031984 CC 1 organelle subcompartment 1 Q9BXS5,Q10567,P61966,O43747 285 1.30e-07 190 4 4 1.000 0.021 GO:0098852 CC 1 lytic vacuole membrane 1 Q9BXS5,Q10567,P61966,O43747 285 1.30e-07 190 4 4 1.000 0.021 GO:0005765 CC 1 lysosomal membrane 1 Q9BXS5,Q10567,P61966,O43747 285 2.18e-07 216 4 4 1.000 0.019 GO:0005774 CC 1 vacuolar membrane 1 Q9BXS5,Q10567,P61966,O43747 285 2.75e-07 72 4 4 1.000 0.056 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 Q9BXS5,Q10567,P61966,O43747 285 2.75e-07 72 4 4 1.000 0.056 REAC:421837 rea 1 Clathrin derived vesicle budding 1 Q9BXS5,Q10567,P61966,O43747 285 3.62e-07 245 4 4 1.000 0.016 GO:0030659 CC 1 cytoplasmic vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 4.25e-07 255 4 4 1.000 0.016 GO:0012506 CC 1 vesicle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 6.10e-07 279 4 4 1.000 0.014 GO:0044437 CC 1 vacuolar part 1 Q9BXS5,Q10567,P61966,O43747 285 8.51e-07 95 4 4 1.000 0.042 REAC:2132295 rea 1 MHC class II antigen presentation 1 Q9BXS5,Q10567,P61966,O43747 285 8.73e-07 305 4 4 1.000 0.013 GO:0051707 BP 1 response to other organism 1 Q9BXS5,Q10567,P61966,O43747 285 8.73e-07 305 4 4 1.000 0.013 GO:0043207 BP 1 response to external biotic stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 1.02e-06 317 4 4 1.000 0.013 GO:0002252 BP 1 immune effector process 1 Q9BXS5,Q10567,P61966,O43747 285 1.11e-06 324 4 4 1.000 0.012 GO:0009607 BP 1 response to biotic stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 1.23e-06 332 4 4 1.000 0.012 GO:0000139 CC 1 Golgi membrane 1 Q9BXS5,Q10567,P61966,O43747 285 1.38e-06 342 4 4 1.000 0.012 GO:0000323 CC 1 lytic vacuole 1 Q9BXS5,Q10567,P61966,O43747 285 1.38e-06 342 4 4 1.000 0.012 GO:0005764 CC 1 lysosome 1 Q9BXS5,Q10567,P61966,O43747 285 1.47e-06 347 4 4 1.000 0.012 GO:0032101 BP 1 regulation of response to external stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 2.18e-06 383 4 4 1.000 0.010 GO:0031347 BP 1 regulation of defense response 1 Q9BXS5,Q10567,P61966,O43747 285 2.44e-06 394 4 4 1.000 0.010 GO:0005773 CC 1 vacuole 1 Q9BXS5,Q10567,P61966,O43747 285 2.59e-06 125 4 4 1.000 0.032 REAC:162909 rea 1 Host Interactions of HIV factors 1 Q9BXS5,Q10567,P61966,O43747 285 5.49e-06 482 4 4 1.000 0.008 GO:0044431 CC 1 Golgi apparatus part 1 Q9BXS5,Q10567,P61966,O43747 285 5.91e-06 9 4 2 0.500 0.222 GO:0048757 BP 1 pigment granule maturation 1 Q9BXS5,O43747 285 5.91e-06 9 4 2 0.500 0.222 GO:0043485 BP 1 endosome to pigment granule transport 1 Q9BXS5,O43747 285 5.91e-06 9 4 2 0.500 0.222 GO:0035646 BP 1 endosome to melanosome transport 1 Q9BXS5,O43747 285 6.30e-06 499 4 4 1.000 0.008 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q9BXS5,Q10567,P61966,O43747 285 9.02e-06 11 4 2 0.500 0.182 GO:0043482 BP 1 cellular pigment accumulation 1 Q9BXS5,O43747 285 9.02e-06 11 4 2 0.500 0.182 GO:0043476 BP 1 pigment accumulation 1 Q9BXS5,O43747 285 1.72e-05 15 4 2 0.500 0.133 GO:0050931 BP 1 pigment cell differentiation 1 Q9BXS5,O43747 285 2.01e-05 666 4 4 1.000 0.006 GO:0006952 BP 1 defense response 1 Q9BXS5,Q10567,P61966,O43747 285 2.31e-05 690 4 4 1.000 0.006 GO:0002682 BP 1 regulation of immune system process 1 Q9BXS5,Q10567,P61966,O43747 285 2.49e-05 219 4 4 1.000 0.018 REAC:162906 rea 1 HIV Infection 1 Q9BXS5,Q10567,P61966,O43747 285 3.11e-05 20 4 2 0.500 0.100 GO:0048066 BP 1 developmental pigmentation 1 Q9BXS5,O43747 285 3.39e-05 759 4 4 1.000 0.005 GO:0098805 CC 1 whole membrane 1 Q9BXS5,Q10567,P61966,O43747 285 3.44e-05 21 4 2 0.500 0.095 GO:0032438 BP 1 melanosome organization 1 Q9BXS5,O43747 285 3.44e-05 21 4 2 0.500 0.095 GO:0048753 BP 1 pigment granule organization 1 Q9BXS5,O43747 285 4.48e-05 814 4 4 1.000 0.005 GO:0080134 BP 1 regulation of response to stress 1 Q9BXS5,Q10567,P61966,O43747 285 4.97e-05 835 4 4 1.000 0.005 GO:0009605 BP 1 response to external stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 5.23e-05 846 4 4 1.000 0.005 GO:0005794 CC 1 Golgi apparatus 1 Q9BXS5,Q10567,P61966,O43747 285 5.75e-05 27 4 2 0.500 0.074 GO:0030119 CC 1 AP-type membrane coat adaptor complex 1 P61966,O43747 285 7.01e-05 910 4 4 1.000 0.004 GO:0097708 CC 1 intracellular vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 7.68e-05 931 4 4 1.000 0.004 GO:0031410 CC 1 cytoplasmic vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 8.16e-05 945 4 4 1.000 0.004 GO:0098588 CC 1 bounding membrane of organelle 1 Q9BXS5,Q10567,P61966,O43747 285 1.03e-04 36 4 2 0.500 0.056 GO:0033059 BP 1 cellular pigmentation 1 Q9BXS5,O43747 285 1.57e-04 346 4 4 1.000 0.012 REAC:5663205 rea 1 Infectious disease 1 Q9BXS5,Q10567,P61966,O43747 285 1.77e-04 47 4 2 0.500 0.043 GO:0043473 BP 1 pigmentation 1 Q9BXS5,O43747 285 1.89e-04 1165 4 4 1.000 0.003 GO:0002376 BP 1 immune system process 1 Q9BXS5,Q10567,P61966,O43747 285 2.70e-04 58 4 2 0.500 0.034 GO:0048475 CC 1 coated membrane 1 P61966,O43747 285 2.70e-04 58 4 2 0.500 0.034 GO:0030117 CC 1 membrane coat 1 P61966,O43747 285 3.94e-04 70 4 2 0.500 0.029 GO:0021700 BP 1 developmental maturation 1 Q9BXS5,O43747 285 4.10e-04 1414 4 4 1.000 0.003 GO:0031090 CC 1 organelle membrane 1 Q9BXS5,Q10567,P61966,O43747 285 8.18e-04 522 4 4 1.000 0.008 REAC:199991 rea 1 Membrane Trafficking 1 Q9BXS5,Q10567,P61966,O43747 285 1.00e-03 549 4 4 1.000 0.007 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9BXS5,Q10567,P61966,O43747 285 1.26e-03 2 4 1 0.250 0.500 GO:0043323 BP 1 positive regulation of natural killer cell degranulation 1 O43747 285 1.26e-03 2 4 1 0.250 0.500 GO:0043321 BP 1 regulation of natural killer cell degranulation 1 O43747 285 1.57e-03 614 4 4 1.000 0.007 REAC:1280218 rea 1 Adaptive Immune System 1 Q9BXS5,Q10567,P61966,O43747 285 1.89e-03 2071 4 4 1.000 0.002 GO:0006950 BP 1 response to stress 1 Q9BXS5,Q10567,P61966,O43747 285 2.00e-03 2101 4 4 1.000 0.002 GO:0048583 BP 1 regulation of response to stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 2.68e-03 2260 4 4 1.000 0.002 GO:0012505 CC 1 endomembrane system 1 Q9BXS5,Q10567,P61966,O43747 285 2.97e-03 720 4 4 1.000 0.006 REAC:1643685 rea 1 Disease 1 Q9BXS5,Q10567,P61966,O43747 285 3.16e-03 5 4 1 0.250 0.200 GO:0043320 BP 1 natural killer cell degranulation 1 O43747 285 3.16e-03 5 4 1 0.250 0.200 GO:0030121 CC 1 AP-1 adaptor complex 1 P61966 285 3.79e-03 6 4 1 0.250 0.167 GO:0090160 BP 1 Golgi to lysosome transport 1 O43747 285 3.79e-03 6 4 1 0.250 0.167 GO:0032816 BP 1 positive regulation of natural killer cell activation 1 O43747 285 3.93e-03 222 4 2 0.500 0.009 GO:0016197 BP 1 endosomal transport 1 Q9BXS5,O43747 285 4.42e-03 7 4 1 0.250 0.143 GO:0030130 CC 1 clathrin coat of trans-Golgi network vesicle 1 P61966 285 5.05e-03 8 4 1 0.250 0.125 GO:0032814 BP 1 regulation of natural killer cell activation 1 O43747 285 5.05e-03 8 4 1 0.250 0.125 GO:0012510 CC 1 trans-Golgi network transport vesicle membrane 1 P61966 285 5.05e-03 8 4 1 0.250 0.125 GO:0002717 BP 1 positive regulation of natural killer cell mediated immunity 1 O43747 285 5.05e-03 8 4 1 0.250 0.125 GO:0045954 BP 1 positive regulation of natural killer cell mediated cytotoxicity 1 O43747 285 5.51e-03 2707 4 4 1.000 0.001 GO:0005829 CC 1 cytosol 1 Q9BXS5,Q10567,P61966,O43747 285 6.25e-03 281 4 2 0.500 0.007 GO:0016050 BP 1 vesicle organization 1 Q9BXS5,O43747 285 6.27e-03 2795 4 4 1.000 0.001 GO:0031982 CC 1 vesicle 1 Q9BXS5,Q10567,P61966,O43747 285 6.31e-03 10 4 1 0.250 0.100 GO:0006896 BP 1 Golgi to vacuole transport 1 O43747 285 6.94e-03 11 4 1 0.250 0.091 GO:0043302 BP 1 positive regulation of leukocyte degranulation 1 O43747 285 8.20e-03 13 4 1 0.250 0.077 GO:0002323 BP 1 natural killer cell activation involved in immune response 1 O43747 285 8.83e-03 14 4 1 0.250 0.071 GO:0002715 BP 1 regulation of natural killer cell mediated immunity 1 O43747 285 8.83e-03 14 4 1 0.250 0.071 GO:0030131 CC 1 clathrin adaptor complex 1 P61966 285 8.83e-03 14 4 1 0.250 0.071 GO:0042269 BP 1 regulation of natural killer cell mediated cytotoxicity 1 O43747 285 9.45e-03 15 4 1 0.250 0.067 GO:0030742 MF 1 GTP-dependent protein binding 1 O43747 285 9.45e-03 15 4 1 0.250 0.067 GO:0001912 BP 1 positive regulation of leukocyte mediated cytotoxicity 1 O43747 285 9.45e-03 15 4 1 0.250 0.067 GO:0031343 BP 1 positive regulation of cell killing 1 O43747 285 1.08e-02 490 4 2 0.500 0.004 MI:hsa-miR-22 mi 1 MI:hsa-miR-22 1 Q10567,P61966 285 1.13e-02 18 4 1 0.250 0.056 GO:0030125 CC 1 clathrin vesicle coat 1 P61966 285 1.20e-02 19 4 1 0.250 0.053 GO:0030140 CC 1 trans-Golgi network transport vesicle 1 P61966 285 1.39e-02 22 4 1 0.250 0.045 GO:0043300 BP 1 regulation of leukocyte degranulation 1 O43747 285 1.39e-02 22 4 1 0.250 0.045 GO:1903307 BP 1 positive regulation of regulated secretory pathway 1 O43747 285 1.51e-02 24 4 1 0.250 0.042 GO:0031341 BP 1 regulation of cell killing 1 O43747 285 1.51e-02 24 4 1 0.250 0.042 GO:0001910 BP 1 regulation of leukocyte mediated cytotoxicity 1 O43747 285 1.53e-02 444 4 2 0.500 0.005 GO:0098796 CC 1 membrane protein complex 1 P61966,O43747 285 1.57e-02 25 4 1 0.250 0.040 GO:0030118 CC 1 clathrin coat 1 P61966 285 1.57e-02 25 4 1 0.250 0.040 GO:0042267 BP 1 natural killer cell mediated cytotoxicity 1 O43747 285 1.57e-02 25 4 1 0.250 0.040 GO:0002228 BP 1 natural killer cell mediated immunity 1 O43747 285 1.64e-02 26 4 1 0.250 0.038 GO:0019894 MF 1 kinesin binding 1 O43747 285 1.64e-02 26 4 1 0.250 0.038 GO:0030101 BP 1 natural killer cell activation 1 O43747 285 1.70e-02 27 4 1 0.250 0.037 GO:0002708 BP 1 positive regulation of lymphocyte mediated immunity 1 O43747 285 1.89e-02 30 4 1 0.250 0.033 GO:0043299 BP 1 leukocyte degranulation 1 O43747 285 2.20e-02 35 4 1 0.250 0.029 GO:0030660 CC 1 Golgi-associated vesicle membrane 1 P61966 285 2.26e-02 36 4 1 0.250 0.028 GO:0002705 BP 1 positive regulation of leukocyte mediated immunity 1 O43747 285 2.26e-02 36 4 1 0.250 0.028 GO:0030120 CC 1 vesicle coat 1 P61966 285 2.39e-02 38 4 1 0.250 0.026 GO:0001909 BP 1 leukocyte mediated cytotoxicity 1 O43747 285 2.58e-02 41 4 1 0.250 0.024 GO:0001906 BP 1 cell killing 1 O43747 285 2.76e-02 44 4 1 0.250 0.023 GO:0002706 BP 1 regulation of lymphocyte mediated immunity 1 O43747 285 3.01e-02 48 4 1 0.250 0.021 GO:0045921 BP 1 positive regulation of exocytosis 1 O43747 285 3.45e-02 55 4 1 0.250 0.018 GO:0005798 CC 1 Golgi-associated vesicle 1 P61966 285 3.57e-02 57 4 1 0.250 0.018 GO:0002285 BP 1 lymphocyte activation involved in immune response 1 O43747 285 3.70e-02 4356 4 4 1.000 0.001 GO:0050896 BP 1 response to stimulus 1 Q9BXS5,Q10567,P61966,O43747 285 3.76e-02 60 4 1 0.250 0.017 GO:1903305 BP 1 regulation of regulated secretory pathway 1 O43747 285 4.07e-02 65 4 1 0.250 0.015 GO:0007041 BP 1 lysosomal transport 1 O43747 285 4.07e-02 65 4 1 0.250 0.015 GO:0002703 BP 1 regulation of leukocyte mediated immunity 1 O43747 285 4.13e-02 66 4 1 0.250 0.015 GO:0002699 BP 1 positive regulation of immune effector process 1 O43747 285 4.22e-02 750 4 2 0.500 0.003 GO:0005215 MF 1 transporter activity 1 Q10567,O43747 285 4.57e-02 73 4 1 0.250 0.014 GO:0030658 CC 1 transport vesicle membrane 1 P61966 285 4.60e-02 4600 4 4 1.000 0.001 GO:0016020 CC 1 membrane 1 Q9BXS5,Q10567,P61966,O43747 285 4.81e-02 77 4 1 0.250 0.013 GO:0002449 BP 1 lymphocyte mediated immunity 1 O43747 285 4.94e-02 79 4 1 0.250 0.013 GO:0006892 BP 1 post-Golgi vesicle-mediated transport 1 O43747 285 4.97e-02 34 4 1 0.250 0.029 HP:0010783 hp 1 Erythema 1 P61966 285 5.00e-02 111 4 4 1.000 0.036 KEGG:04142 keg 1 Lysosome 1 Q9BXS5,Q10567,P61966,O43747 285 5.00e-02 80 4 1 0.250 0.013 GO:0055037 CC 1 recycling endosome 1 O43747 285 5.00e-02 1 4 1 0.250 1.000 OMIM:609313 omi 1 MENTAL RETARDATION, ENTEROPATHY, DEAFNESS, PERIPHERAL NEUROPATHY,ICHTHYOSIS, AND KERATODERMA; MEDNIK;;ERYTHROKERATODERMIA VARIABILIS 3; EKV3;;ERYTHROKERATODERMIA VARIABILIS, KAMOURASKA TYPE 1 P61966 285 5.00e-02 3 4 1 0.250 0.333 CORUM:1090 cor 1 APLG1-Rababtin5 complex 1 O43747 285 5.00e-02 3 4 1 0.250 0.333 CORUM:5165 cor 1 AP1G1-PACS1-FURIN complex 1 O43747 285 5.00e-02 1 4 1 0.250 1.000 TF:M00279_1 tf 1 Factor: MIF-1; motif: NNGTTGCWWGGYAACNGS; match class: 1 1 Q9BXS5 285 5.00e-02 1457 4 4 1.000 0.003 REAC:168256 rea 1 Immune System 1 Q9BXS5,Q10567,P61966,O43747 286 2.19e-03 793 5 3 0.600 0.004 TF:M00072_1 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 1 1 Q9NQG6,Q9NYH9,Q8WY07 286 8.22e-03 21 5 1 0.200 0.048 TF:M03978_0 tf 1 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN; match class: 0 1 Q9NQG6 286 8.32e-03 4885 5 5 1.000 0.001 TF:M00912_1 tf 1 Factor: C/EBP; motif: NTTRCNNAANNN; match class: 1 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 8.61e-03 22 5 1 0.200 0.045 TF:M06402_0 tf 1 Factor: ZNF493; motif: NGGTCAAAAAGA; match class: 0 1 Q96P53 286 9.39e-03 24 5 1 0.200 0.042 TF:M04174_1 tf 1 Factor: ID4; motif: NRCACCTGNN; match class: 1 1 Q9NYH9 286 1.10e-02 28 5 1 0.200 0.036 TF:M06726_0 tf 1 Factor: ZNF624; motif: NGCTCCTAATGA; match class: 0 1 Q9NYH9 286 1.29e-02 33 5 1 0.200 0.030 TF:M06429_0 tf 1 Factor: ZSCAN2; motif: NAGGAAARCCKC; match class: 0 1 Q96P53 286 1.31e-02 3035 5 4 0.800 0.001 TF:M02100_0 tf 1 Factor: MyoD; motif: CASCTGNCN; match class: 0 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 1.51e-02 5502 5 5 1.000 0.001 TF:M00096_0 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 1.73e-02 554 5 2 0.400 0.004 TF:M04323_0 tf 1 Factor: GBX2; motif: TAATTGNNCAATTA; match class: 0 1 Q9NQG6,Q8WY07 286 1.83e-02 47 5 1 0.200 0.021 TF:M05846_0 tf 1 Factor: ZNF689; motif: NRGGTTAAGTGC; match class: 0 1 Q9NYH9 286 1.90e-02 3354 5 4 0.800 0.001 TF:M01860_1 tf 1 Factor: AP-4; motif: NCAGCTGYNGNCN; match class: 1 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 1.97e-02 592 5 2 0.400 0.003 TF:M01231_1 tf 1 Factor: ZNF515; motif: GTGGGGGGTM; match class: 1 1 P43304,Q8WY07 286 2.13e-02 618 5 2 0.400 0.003 TF:M01798_1 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 1 1 Q9NQG6,Q9NYH9 286 2.22e-02 57 5 1 0.200 0.018 TF:M01650_0 tf 1 Factor: PNR; motif: RAGRTCAAARRTCA; match class: 0 1 Q96P53 286 2.26e-02 540 5 2 0.400 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q9NYH9,P43304 286 2.26e-02 58 5 1 0.200 0.017 TF:M06719_1 tf 1 Factor: ZNF430; motif: NCGTAMAAAAGA; match class: 1 1 P43304 286 2.35e-02 3552 5 4 0.800 0.001 TF:M05386_1 tf 1 Factor: KLF17; motif: NGGGCGG; match class: 1 1 Q9NQG6,Q9NYH9,P43304,Q96P53 286 2.35e-02 3552 5 4 0.800 0.001 TF:M05499_1 tf 1 Factor: LKLF; motif: NGGGCGG; match class: 1 1 Q9NQG6,Q9NYH9,P43304,Q96P53 286 2.41e-02 62 5 1 0.200 0.016 TF:M05714_0 tf 1 Factor: Evi-1; motif: KGGTCMMAACTN; match class: 0 1 Q96P53 286 2.56e-02 3635 5 4 0.800 0.001 TF:M00927_0 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 0 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 2.57e-02 66 5 1 0.200 0.015 TF:M05546_1 tf 1 Factor: EOS; motif: TGGTTATM; match class: 1 1 Q96P53 286 2.61e-02 3653 5 4 0.800 0.001 TF:M01247_1 tf 1 Factor: Nanog; motif: NNWNNANAACAAWRGNNNNN; match class: 1 1 Q9NQG6,Q9NYH9,Q96P53,Q8WY07 286 2.64e-02 68 5 1 0.200 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 Q9NQG6 286 2.71e-02 6184 5 5 1.000 0.001 TF:M00706_0 tf 1 Factor: TFII-I; motif: RGAGGKAGG; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 2.91e-02 75 5 1 0.200 0.013 TF:M06462_0 tf 1 Factor: ZNF441; motif: KGKTCTTGMTSG; match class: 0 1 P43304 286 2.96e-02 3780 5 4 0.800 0.001 TF:M00173_0 tf 1 Factor: AP-1; motif: RSTGACTNANW; match class: 0 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 3.06e-02 634 5 2 0.400 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q9NYH9,P43304 286 3.07e-02 3817 5 4 0.800 0.001 TF:M07345_0 tf 1 Factor: ZNF515; motif: SCTGCTGK; match class: 0 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 3.18e-02 82 5 1 0.200 0.012 TF:M06024_0 tf 1 Factor: Zipro1; motif: NCMKGACGACT; match class: 0 1 Q9NYH9 286 3.20e-02 650 5 2 0.400 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q9NYH9,P43304 286 3.22e-02 83 5 1 0.200 0.012 TF:M06720_0 tf 1 Factor: ZNF430; motif: NTGGAGGGCAGA; match class: 0 1 Q9NYH9 286 3.27e-02 774 5 2 0.400 0.003 TF:M03914_1 tf 1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 1 Q9NQG6,P43304 286 3.30e-02 85 5 1 0.200 0.012 TF:M06863_0 tf 1 Factor: ZNF789; motif: NGGTKAGGCGGW; match class: 0 1 Q8WY07 286 3.30e-02 6433 5 5 1.000 0.001 TF:M00130_0 tf 1 Factor: FOXD3; motif: NAWTGTTTRTTT; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 3.44e-02 3938 5 4 0.800 0.001 TF:M00072_0 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 0 1 Q9NQG6,Q9NYH9,Q96P53,Q8WY07 286 3.45e-02 89 5 1 0.200 0.011 TF:M04475_0 tf 1 Factor: NR2F6; motif: NRGGTCAAAGGTCA; match class: 0 1 Q96P53 286 3.51e-02 804 5 2 0.400 0.002 TF:M00734_0 tf 1 Factor: CIZ; motif: SAAAAANNN; match class: 0 1 Q9NQG6,Q96P53 286 3.56e-02 92 5 1 0.200 0.011 TF:M04400_1 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 1 1 Q8WY07 286 3.68e-02 2151 5 3 0.600 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 Q9NQG6,P43304,Q96P53 286 3.69e-02 4013 5 4 0.800 0.001 TF:M03843_0 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q8WY07 286 3.70e-02 6583 5 5 1.000 0.001 TF:M07037_0 tf 1 Factor: C/EBPalpha; motif: NNNNNTTKCNNAAN; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 3.75e-02 97 5 1 0.200 0.010 TF:M06106_0 tf 1 Factor: ZNF14; motif: KGGWCCATCAGT; match class: 0 1 P43304 286 3.87e-02 6644 5 5 1.000 0.001 TF:M00124_0 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 3.98e-02 4097 5 4 0.800 0.001 TF:M03969_0 tf 1 Factor: ELF5; motif: ANSMGGAAGTN; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53 286 4.09e-02 6716 5 5 1.000 0.001 TF:M06191_0 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 4.09e-02 6716 5 5 1.000 0.001 TF:M06190_0 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 4.21e-02 4160 5 4 0.800 0.001 TF:M01722_1 tf 1 Factor: RORbeta; motif: TGACCYA; match class: 1 1 Q9NQG6,P43304,Q96P53,Q8WY07 286 4.37e-02 332 5 2 0.400 0.006 MI:hsa-miR-373* mi 1 MI:hsa-miR-373* 1 Q9NYH9,Q96P53 286 4.48e-02 6840 5 5 1.000 0.001 TF:M03547_0 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 0 1 Q9NQG6,Q9NYH9,P43304,Q96P53,Q8WY07 286 4.51e-02 117 5 1 0.200 0.009 TF:M06173_0 tf 1 Factor: ZNF85; motif: KGGCGGAAGM; match class: 0 1 Q9NYH9 286 4.68e-02 939 5 2 0.400 0.002 TF:M03843_1 tf 1 Factor: POU4F1; motif: TAATTTATKCN; match class: 1 1 P43304,Q8WY07 286 4.75e-02 19 5 1 0.200 0.053 OMIM:125853 omi 1 DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM;;DIABETES MELLITUS, TYPE II; T2D;;NONINSULIN-DEPENDENT DIABETES MELLITUS;;MATURITY-ONSET DIABETESINSULIN RESISTANCE, SUSCEPTIBILITY TO, INCLUDED;;DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST, INCLUDED 1 P43304 286 4.77e-02 949 5 2 0.400 0.002 TF:M04071_1 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 1 1 Q96P53,Q8WY07 286 4.96e-02 969 5 2 0.400 0.002 TF:M00707_0 tf 1 Factor: TFIIA; motif: TMTRWRAGGRSS; match class: 0 1 Q96P53,Q8WY07 286 4.99e-02 972 5 2 0.400 0.002 TF:M07432_1 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 1 1 Q9NYH9,Q96P53 286 5.00e-02 356 5 2 0.400 0.006 MI:hsa-miR-616* mi 1 MI:hsa-miR-616* 1 Q9NYH9,Q96P53 286 5.00e-02 1 5 1 0.200 1.000 GO:0004368 MF 1 glycerol-3-phosphate dehydrogenase activity 1 P43304 286 5.00e-02 17 5 1 0.200 0.059 REAC:352230 rea 1 Amino acid transport across the plasma membrane 1 Q8WY07 286 5.00e-02 20 5 1 0.200 0.050 OMIM:606391 omi 1 MODY 1 P43304 286 5.00e-02 1 5 1 0.200 1.000 GO:0016901 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor 1 P43304 287 3.77e-03 628 3 3 1.000 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 Q9BV97,Q96C28,Q14593 287 3.67e-02 143 3 1 0.333 0.007 GO:0000978 MF 1 RNA polymerase II core promoter proximal region sequence-specific DNA binding 1 Q14593 287 3.90e-02 152 3 1 0.333 0.007 GO:0000987 MF 1 core promoter proximal region sequence-specific DNA binding 1 Q14593 287 3.93e-02 153 3 1 0.333 0.007 GO:0001159 MF 1 core promoter proximal region DNA binding 1 Q14593 287 5.00e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 Q9BV97,Q96C28,Q14593 287 5.00e-02 128 3 2 0.667 0.016 TF:M04411_1 tf 1 Factor: NKX2-3; motif: NCCACTTRAN; match class: 1 1 Q96C28,Q14593 288 1.40e-02 12 2 1 0.500 0.083 GO:0030057 CC 1 desmosome 1 Q99569 288 2.36e-02 178 2 2 1.000 0.011 TF:M00411_1 tf 1 Factor: HNF4alpha1; motif: NRGGNCAAAGGTCAN; match class: 1 1 Q9Y240,Q99569 288 2.56e-02 22 2 1 0.500 0.045 GO:0051233 CC 1 spindle midzone 1 Q99569 288 2.91e-02 25 2 1 0.500 0.040 GO:0032467 BP 1 positive regulation of cytokinesis 1 Q99569 288 3.37e-02 29 2 1 0.500 0.034 GO:0051781 BP 1 positive regulation of cell division 1 Q99569 288 3.72e-02 32 2 1 0.500 0.031 GO:0044291 CC 1 cell-cell contact zone 1 Q99569 288 4.58e-02 248 2 2 1.000 0.008 TF:M03828_1 tf 1 Factor: HNF-4; motif: NNNNNNNGNNCAAAGKYCAN; match class: 1 1 Q9Y240,Q99569 288 5.00e-02 43 2 1 0.500 0.023 GO:0008083 MF 1 growth factor activity 1 Q9Y240 288 5.00e-02 43 2 1 0.500 0.023 GO:0072686 CC 1 mitotic spindle 1 Q99569 288 5.00e-02 259 2 2 1.000 0.008 TF:M00764_1 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 1 1 Q9Y240,Q99569 289 1.15e-09 30 4 4 1.000 0.133 KEGG:04215 keg 1 Apoptosis - multiple species 1 P98170,O43464,P55211,Q96P09 289 3.16e-08 121 4 4 1.000 0.033 GO:0043281 BP 1 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 P98170,O43464,P55211,Q96P09 289 5.53e-08 139 4 4 1.000 0.029 GO:2000116 BP 1 regulation of cysteine-type endopeptidase activity 1 P98170,O43464,P55211,Q96P09 289 1.13e-07 166 4 4 1.000 0.024 GO:0052548 BP 1 regulation of endopeptidase activity 1 P98170,O43464,P55211,Q96P09 289 1.40e-07 175 4 4 1.000 0.023 GO:0052547 BP 1 regulation of peptidase activity 1 P98170,O43464,P55211,Q96P09 289 4.61e-06 417 4 4 1.000 0.010 GO:0030162 BP 1 regulation of proteolysis 1 P98170,O43464,P55211,Q96P09 289 5.18e-06 7 4 2 0.500 0.286 GO:0097340 BP 1 inhibition of cysteine-type endopeptidase activity 1 P98170,Q96P09 289 5.18e-06 7 4 2 0.500 0.286 GO:1990001 BP 1 inhibition of cysteine-type endopeptidase activity involved in apoptotic process 1 P98170,Q96P09 289 5.18e-06 7 4 2 0.500 0.286 GO:0097341 BP 1 zymogen inhibition 1 P98170,Q96P09 289 7.45e-06 5 4 2 0.500 0.400 REAC:111469 rea 1 SMAC-mediated apoptotic response 1 P98170,P55211 289 7.45e-06 5 4 2 0.500 0.400 REAC:111464 rea 1 SMAC-mediated dissociation of IAP:caspase complexes 1 P98170,P55211 289 7.45e-06 5 4 2 0.500 0.400 REAC:111463 rea 1 SMAC binds to IAPs 1 P98170,P55211 289 1.00e-05 506 4 4 1.000 0.008 GO:0051336 BP 1 regulation of hydrolase activity 1 P98170,O43464,P55211,Q96P09 289 1.56e-05 7 4 2 0.500 0.286 REAC:111471 rea 1 Apoptotic factor-mediated response 1 P98170,P55211 289 2.00e-05 84 4 3 0.750 0.036 KEGG:05222 keg 1 Small cell lung cancer 1 P98170,P55211,Q96P09 289 2.11e-05 145 4 3 0.750 0.021 GO:0016485 BP 1 protein processing 1 P98170,O43464,Q96P09 289 2.90e-05 95 4 3 0.750 0.032 KEGG:05145 keg 1 Toxoplasmosis 1 P98170,P55211,Q96P09 289 3.00e-05 163 4 3 0.750 0.018 GO:0051604 BP 1 protein maturation 1 P98170,O43464,Q96P09 289 3.35e-05 17 4 2 0.500 0.118 GO:0043027 MF 1 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1 P98170,Q96P09 289 4.22e-05 19 4 2 0.500 0.105 GO:0010955 BP 1 negative regulation of protein processing 1 P98170,Q96P09 289 4.22e-05 19 4 2 0.500 0.105 GO:1903318 BP 1 negative regulation of protein maturation 1 P98170,Q96P09 289 4.76e-05 746 4 4 1.000 0.005 GO:0042981 BP 1 regulation of apoptotic process 1 P98170,O43464,P55211,Q96P09 289 5.02e-05 756 4 4 1.000 0.005 GO:0043067 BP 1 regulation of programmed cell death 1 P98170,O43464,P55211,Q96P09 289 5.58e-05 118 4 3 0.750 0.025 KEGG:04210 keg 1 Apoptosis 1 P98170,O43464,P55211 289 6.53e-05 3 4 2 0.500 0.667 CORUM:5317 cor 1 LATS1-HTRA2-BIRC4 complex 1 P98170,O43464 289 6.65e-05 811 4 4 1.000 0.005 GO:0010941 BP 1 regulation of cell death 1 P98170,O43464,P55211,Q96P09 289 1.14e-04 31 4 2 0.500 0.065 GO:0043028 MF 1 cysteine-type endopeptidase regulator activity involved in apoptotic process 1 P98170,Q96P09 289 1.18e-04 936 4 4 1.000 0.004 GO:0006915 BP 1 apoptotic process 1 P98170,O43464,P55211,Q96P09 289 1.19e-04 937 4 4 1.000 0.004 GO:0006508 BP 1 proteolysis 1 P98170,O43464,P55211,Q96P09 289 1.22e-04 32 4 2 0.500 0.062 GO:0097192 BP 1 extrinsic apoptotic signaling pathway in absence of ligand 1 O43464,P55211 289 1.22e-04 32 4 2 0.500 0.062 GO:0038034 BP 1 signal transduction in absence of ligand 1 O43464,P55211 289 1.28e-04 956 4 4 1.000 0.004 GO:0012501 BP 1 programmed cell death 1 P98170,O43464,P55211,Q96P09 289 1.46e-04 35 4 2 0.500 0.057 GO:0004869 MF 1 cysteine-type endopeptidase inhibitor activity 1 P98170,Q96P09 289 1.73e-04 1029 4 4 1.000 0.004 GO:0008219 BP 1 cell death 1 P98170,O43464,P55211,Q96P09 289 2.03e-04 1071 4 4 1.000 0.004 GO:0050790 BP 1 regulation of catalytic activity 1 P98170,O43464,P55211,Q96P09 289 2.43e-04 45 4 2 0.500 0.044 GO:0070613 BP 1 regulation of protein processing 1 P98170,Q96P09 289 2.43e-04 45 4 2 0.500 0.044 GO:1903317 BP 1 regulation of protein maturation 1 P98170,Q96P09 289 2.54e-04 46 4 2 0.500 0.043 GO:0043154 BP 1 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 P98170,Q96P09 289 2.77e-04 48 4 2 0.500 0.042 GO:0005876 CC 1 spindle microtubule 1 P98170,Q96P09 289 3.38e-04 53 4 2 0.500 0.038 GO:0090307 BP 1 mitotic spindle assembly 1 P98170,Q96P09 289 3.51e-04 54 4 2 0.500 0.037 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 P98170,Q96P09 289 3.78e-04 56 4 2 0.500 0.036 GO:2000117 BP 1 negative regulation of cysteine-type endopeptidase activity 1 P98170,Q96P09 289 4.49e-04 61 4 2 0.500 0.033 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 O43464,P55211 289 4.69e-04 408 4 3 0.750 0.007 GO:0043066 BP 1 negative regulation of apoptotic process 1 P98170,O43464,Q96P09 289 4.97e-04 416 4 3 0.750 0.007 GO:0043069 BP 1 negative regulation of programmed cell death 1 P98170,O43464,Q96P09 289 5.00e-04 1342 4 4 1.000 0.003 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 P98170,O43464,P55211,Q96P09 289 5.49e-04 39 4 2 0.500 0.051 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 P98170,P55211 289 5.72e-04 1388 4 4 1.000 0.003 GO:0065009 BP 1 regulation of molecular function 1 P98170,O43464,P55211,Q96P09 289 6.09e-04 71 4 2 0.500 0.028 GO:0010951 BP 1 negative regulation of endopeptidase activity 1 P98170,Q96P09 289 6.19e-04 448 4 3 0.750 0.007 GO:0060548 BP 1 negative regulation of cell death 1 P98170,O43464,Q96P09 289 6.20e-04 1416 4 4 1.000 0.003 GO:0007166 BP 1 cell surface receptor signaling pathway 1 P98170,O43464,P55211,Q96P09 289 6.66e-04 1442 4 4 1.000 0.003 GO:0051246 BP 1 regulation of protein metabolic process 1 P98170,O43464,P55211,Q96P09 289 6.80e-04 75 4 2 0.500 0.027 GO:0043280 BP 1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 O43464,P55211 289 6.98e-04 76 4 2 0.500 0.026 GO:0010466 BP 1 negative regulation of peptidase activity 1 P98170,Q96P09 289 6.98e-04 76 4 2 0.500 0.026 GO:0051225 BP 1 spindle assembly 1 P98170,Q96P09 289 8.33e-04 83 4 2 0.500 0.024 GO:2001056 BP 1 positive regulation of cysteine-type endopeptidase activity 1 O43464,P55211 289 8.94e-04 86 4 2 0.500 0.023 GO:0004866 MF 1 endopeptidase inhibitor activity 1 P98170,Q96P09 289 9.36e-04 88 4 2 0.500 0.023 GO:0007052 BP 1 mitotic spindle organization 1 P98170,Q96P09 289 9.58e-04 89 4 2 0.500 0.022 GO:0030414 MF 1 peptidase inhibitor activity 1 P98170,Q96P09 289 9.79e-04 90 4 2 0.500 0.022 GO:0090263 BP 1 positive regulation of canonical Wnt signaling pathway 1 P98170,Q96P09 289 9.79e-04 90 4 2 0.500 0.022 GO:0010950 BP 1 positive regulation of endopeptidase activity 1 O43464,P55211 289 1.00e-03 91 4 2 0.500 0.022 GO:0061135 MF 1 endopeptidase regulator activity 1 P98170,Q96P09 289 1.07e-03 94 4 2 0.500 0.021 GO:0010952 BP 1 positive regulation of peptidase activity 1 O43464,P55211 289 1.15e-03 325 4 3 0.750 0.009 KEGG:05200 keg 1 Pathways in cancer 1 P98170,P55211,Q96P09 289 1.31e-03 71 4 2 0.500 0.028 KEGG:01524 keg 1 Platinum drug resistance 1 P98170,P55211 289 1.35e-03 582 4 3 0.750 0.005 GO:0030234 MF 1 enzyme regulator activity 1 P98170,P55211,Q96P09 289 1.42e-03 592 4 3 0.750 0.005 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P98170,O43464,P55211 289 1.60e-03 115 4 2 0.500 0.017 GO:0030177 BP 1 positive regulation of Wnt signaling pathway 1 P98170,Q96P09 289 1.63e-03 116 4 2 0.500 0.017 GO:0061134 MF 1 peptidase regulator activity 1 P98170,Q96P09 289 1.71e-03 119 4 2 0.500 0.017 GO:0045861 BP 1 negative regulation of proteolysis 1 P98170,Q96P09 289 1.80e-03 122 4 2 0.500 0.016 GO:0097191 BP 1 extrinsic apoptotic signaling pathway 1 O43464,P55211 289 1.83e-03 123 4 2 0.500 0.016 GO:0007051 BP 1 spindle organization 1 P98170,Q96P09 289 1.90e-03 2 4 1 0.250 0.500 GO:0043293 CC 1 apoptosome 1 P55211 289 1.90e-03 2 4 1 0.250 0.500 GO:1902530 BP 1 positive regulation of protein linear polyubiquitination 1 P98170 289 1.90e-03 2 4 1 0.250 0.500 GO:1902528 BP 1 regulation of protein linear polyubiquitination 1 P98170 289 2.85e-03 3 4 1 0.250 0.333 GO:1902916 BP 1 positive regulation of protein polyubiquitination 1 P98170 289 2.97e-03 1 4 1 0.250 1.000 OMIM:300635 omi 1 LYMPHOPROLIFERATIVE SYNDROME, X-LINKED, 2; XLP2;;XIAP DEFICIENCY 1 P98170 289 2.97e-03 1 4 1 0.250 1.000 OMIM:610297 omi 1 PARKINSON DISEASE 13, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO; PARK13 1 O43464 289 3.00e-03 763 4 3 0.750 0.004 GO:0009967 BP 1 positive regulation of signal transduction 1 P98170,O43464,Q96P09 289 3.01e-03 2101 4 4 1.000 0.002 GO:0048583 BP 1 regulation of response to stimulus 1 P98170,O43464,P55211,Q96P09 289 3.16e-03 162 4 2 0.500 0.012 GO:0060828 BP 1 regulation of canonical Wnt signaling pathway 1 P98170,Q96P09 289 3.32e-03 166 4 2 0.500 0.012 GO:0005874 CC 1 microtubule 1 P98170,Q96P09 289 3.43e-03 798 4 3 0.750 0.004 GO:0010647 BP 1 positive regulation of cell communication 1 P98170,O43464,Q96P09 289 3.44e-03 169 4 2 0.500 0.012 GO:0097193 BP 1 intrinsic apoptotic signaling pathway 1 O43464,P55211 289 3.48e-03 170 4 2 0.500 0.012 GO:0051346 BP 1 negative regulation of hydrolase activity 1 P98170,Q96P09 289 3.50e-03 804 4 3 0.750 0.004 GO:0023056 BP 1 positive regulation of signaling 1 P98170,O43464,Q96P09 289 3.60e-03 118 4 2 0.500 0.017 KEGG:05012 keg 1 Parkinson's disease 1 O43464,P55211 289 3.63e-03 814 4 3 0.750 0.004 GO:0080134 BP 1 regulation of response to stress 1 P98170,O43464,P55211 289 3.64e-03 174 4 2 0.500 0.011 GO:0005819 CC 1 spindle 1 P98170,Q96P09 289 3.80e-03 4 4 1 0.250 0.250 GO:2001241 BP 1 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 O43464 289 3.82e-03 828 4 3 0.750 0.004 GO:0098772 MF 1 molecular function regulator 1 P98170,P55211,Q96P09 289 3.88e-03 832 4 3 0.750 0.004 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 P98170,O43464,P55211 289 3.97e-03 124 4 2 0.500 0.016 KEGG:04120 keg 1 Ubiquitin mediated proteolysis 1 P98170,Q96P09 289 4.39e-03 191 4 2 0.500 0.010 GO:0060070 BP 1 canonical Wnt signaling pathway 1 P98170,Q96P09 289 4.57e-03 880 4 3 0.750 0.003 GO:0051247 BP 1 positive regulation of protein metabolic process 1 P98170,O43464,P55211 289 4.75e-03 5 4 1 0.250 0.200 GO:0097039 BP 1 protein linear polyubiquitination 1 P98170 289 4.75e-03 5 4 1 0.250 0.200 GO:0070424 BP 1 regulation of nucleotide-binding oligomerization domain containing signaling pathway 1 P98170 289 5.29e-03 210 4 2 0.500 0.010 GO:0030111 BP 1 regulation of Wnt signaling pathway 1 P98170,Q96P09 289 5.39e-03 3 4 1 0.250 0.333 REAC:111458 rea 1 Formation of apoptosome 1 P55211 289 5.65e-03 217 4 2 0.500 0.009 GO:0004857 MF 1 enzyme inhibitor activity 1 P98170,Q96P09 289 5.70e-03 6 4 1 0.250 0.167 GO:0016540 BP 1 protein autoprocessing 1 O43464 289 5.75e-03 219 4 2 0.500 0.009 GO:0004175 MF 1 endopeptidase activity 1 O43464,P55211 289 6.64e-03 7 4 1 0.250 0.143 GO:0035458 BP 1 cellular response to interferon-beta 1 O43464 289 6.67e-03 236 4 2 0.500 0.008 GO:0007067 BP 1 mitotic nuclear division 1 P98170,Q96P09 289 7.21e-03 398 4 2 0.500 0.005 MI:hsa-miR-625 mi 1 MI:hsa-miR-625 1 O43464,P55211 289 7.59e-03 8 4 1 0.250 0.125 GO:0008635 BP 1 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 1 P55211 289 7.59e-03 8 4 1 0.250 0.125 GO:1902914 BP 1 regulation of protein polyubiquitination 1 P98170 289 7.83e-03 256 4 2 0.500 0.008 GO:0045862 BP 1 positive regulation of proteolysis 1 O43464,P55211 289 8.44e-03 266 4 2 0.500 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 P98170,Q96P09 289 8.48e-03 1086 4 3 0.750 0.003 GO:0048584 BP 1 positive regulation of response to stimulus 1 P98170,O43464,Q96P09 289 8.54e-03 9 4 1 0.250 0.111 GO:0036344 BP 1 platelet morphogenesis 1 P55211 289 8.54e-03 9 4 1 0.250 0.111 GO:0030220 BP 1 platelet formation 1 P55211 289 8.90e-03 3 4 1 0.250 0.333 OMIM:308240 omi 1 X-linked/Autosomal Lymphoproliferative Syndrome 1 P98170 289 8.95e-03 274 4 2 0.500 0.007 GO:0099081 CC 1 supramolecular polymer 1 P98170,Q96P09 289 8.95e-03 274 4 2 0.500 0.007 GO:0099512 CC 1 supramolecular fiber 1 P98170,Q96P09 289 8.97e-03 5 4 1 0.250 0.200 REAC:111459 rea 1 Activation of caspases through apoptosome-mediated cleavage 1 P55211 289 8.97e-03 5 4 1 0.250 0.200 REAC:111461 rea 1 Cytochrome c-mediated apoptotic response 1 P55211 289 8.98e-03 2761 4 4 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 P98170,O43464,P55211,Q96P09 289 9.10e-03 159 4 2 0.500 0.013 REAC:109581 rea 1 Apoptosis 1 P98170,P55211 289 9.44e-03 457 4 2 0.500 0.004 MI:hsa-miR-875-5p mi 1 MI:hsa-miR-875-5p 1 O43464,P55211 289 9.44e-03 162 4 2 0.500 0.012 REAC:5357801 rea 1 Programmed Cell Death 1 P98170,P55211 289 9.47e-03 1128 4 3 0.750 0.003 GO:0007049 BP 1 cell cycle 1 P98170,O43464,Q96P09 289 9.49e-03 10 4 1 0.250 0.100 GO:0035456 BP 1 response to interferon-beta 1 O43464 289 9.49e-03 10 4 1 0.250 0.100 GO:0035631 CC 1 CD40 receptor complex 1 O43464 289 1.01e-02 292 4 2 0.500 0.007 GO:0051345 BP 1 positive regulation of hydrolase activity 1 O43464,P55211 289 1.03e-02 294 4 2 0.500 0.007 GO:0099080 CC 1 supramolecular complex 1 P98170,Q96P09 289 1.04e-02 11 4 1 0.250 0.091 GO:0055070 BP 1 copper ion homeostasis 1 P98170 289 1.04e-02 11 4 1 0.250 0.091 GO:0097153 MF 1 cysteine-type endopeptidase activity involved in apoptotic process 1 P55211 289 1.05e-02 1168 4 3 0.750 0.003 GO:1902589 BP 1 single-organism organelle organization 1 P98170,O43464,Q96P09 289 1.08e-02 301 4 2 0.500 0.007 GO:0198738 BP 1 cell-cell signaling by wnt 1 P98170,Q96P09 289 1.08e-02 301 4 2 0.500 0.007 GO:0016055 BP 1 Wnt signaling pathway 1 P98170,Q96P09 289 1.08e-02 302 4 2 0.500 0.007 GO:0004842 MF 1 ubiquitin-protein transferase activity 1 P98170,Q96P09 289 1.11e-02 306 4 2 0.500 0.007 GO:0043065 BP 1 positive regulation of apoptotic process 1 O43464,P55211 289 1.13e-02 309 4 2 0.500 0.006 GO:0000280 BP 1 nuclear division 1 P98170,Q96P09 289 1.14e-02 12 4 1 0.250 0.083 GO:2001269 BP 1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1 O43464 289 1.15e-02 1204 4 3 0.750 0.002 GO:0005856 CC 1 cytoskeleton 1 P98170,O43464,Q96P09 289 1.15e-02 311 4 2 0.500 0.006 GO:0043068 BP 1 positive regulation of programmed cell death 1 O43464,P55211 289 1.17e-02 1212 4 3 0.750 0.002 GO:0033554 BP 1 cellular response to stress 1 P98170,O43464,P55211 289 1.19e-02 316 4 2 0.500 0.006 GO:0071363 BP 1 cellular response to growth factor stimulus 1 P98170,O43464 289 1.20e-02 318 4 2 0.500 0.006 GO:0019787 MF 1 ubiquitin-like protein transferase activity 1 P98170,Q96P09 289 1.23e-02 2990 4 4 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.24e-02 323 4 2 0.500 0.006 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 P98170,Q96P09 289 1.25e-02 2997 4 4 1.000 0.001 GO:0080090 BP 1 regulation of primary metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.25e-02 325 4 2 0.500 0.006 GO:0010942 BP 1 positive regulation of cell death 1 O43464,P55211 289 1.26e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 P98170,O43464,P55211,Q96P09 289 1.26e-02 326 4 2 0.500 0.006 GO:0070848 BP 1 response to growth factor 1 P98170,O43464 289 1.28e-02 534 4 2 0.500 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 P98170,P55211 289 1.29e-02 3022 4 4 1.000 0.001 GO:0031323 BP 1 regulation of cellular metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.29e-02 330 4 2 0.500 0.006 GO:0097190 BP 1 apoptotic signaling pathway 1 O43464,P55211 289 1.29e-02 330 4 2 0.500 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 P98170,Q96P09 289 1.31e-02 3033 4 4 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 P98170,O43464,P55211,Q96P09 289 1.36e-02 3063 4 4 1.000 0.001 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.37e-02 340 4 2 0.500 0.006 GO:0048285 BP 1 organelle fission 1 P98170,Q96P09 289 1.42e-02 15 4 1 0.250 0.067 GO:1902176 BP 1 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 O43464 289 1.42e-02 15 4 1 0.250 0.067 GO:2001267 BP 1 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1 O43464 289 1.51e-02 357 4 2 0.500 0.006 GO:0070011 MF 1 peptidase activity, acting on L-amino acid peptides 1 O43464,P55211 289 1.58e-02 366 4 2 0.500 0.005 GO:0008233 MF 1 peptidase activity 1 O43464,P55211 289 1.59e-02 3185 4 4 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.61e-02 9 4 1 0.250 0.111 REAC:418889 rea 1 Ligand-independent caspase activation via DCC 1 P55211 289 1.75e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 P98170,O43464,P55211,Q96P09 289 1.75e-02 3263 4 4 1.000 0.001 GO:0019222 BP 1 regulation of metabolic process 1 P98170,O43464,P55211,Q96P09 289 1.76e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 P98170,O43464,P55211,Q96P09 289 1.78e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 P98170,O43464,P55211,Q96P09 289 1.89e-02 20 4 1 0.250 0.050 GO:2001239 BP 1 regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 O43464 289 1.92e-02 404 4 2 0.500 0.005 GO:0080135 BP 1 regulation of cellular response to stress 1 O43464,P55211 289 2.06e-02 419 4 2 0.500 0.005 GO:0043086 BP 1 negative regulation of catalytic activity 1 P98170,Q96P09 289 2.08e-02 22 4 1 0.250 0.045 GO:1902175 BP 1 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1 O43464 289 2.08e-02 22 4 1 0.250 0.045 GO:2001238 BP 1 positive regulation of extrinsic apoptotic signaling pathway 1 O43464 289 2.15e-02 12 4 1 0.250 0.083 REAC:5675482 rea 1 Regulation of necroptotic cell death 1 P98170 289 2.18e-02 23 4 1 0.250 0.043 GO:1900408 BP 1 negative regulation of cellular response to oxidative stress 1 O43464 289 2.18e-02 23 4 1 0.250 0.043 GO:1902883 BP 1 negative regulation of response to oxidative stress 1 O43464 289 2.18e-02 23 4 1 0.250 0.043 GO:1903202 BP 1 negative regulation of oxidative stress-induced cell death 1 O43464 289 2.31e-02 1533 4 3 0.750 0.002 GO:0035556 BP 1 intracellular signal transduction 1 P98170,O43464,P55211 289 2.32e-02 445 4 2 0.500 0.004 GO:0070925 BP 1 organelle assembly 1 P98170,Q96P09 289 2.33e-02 13 4 1 0.250 0.077 REAC:198323 rea 1 AKT phosphorylates targets in the cytosol 1 P55211 289 2.46e-02 459 4 2 0.500 0.004 GO:0007017 BP 1 microtubule-based process 1 P98170,Q96P09 289 2.49e-02 1573 4 3 0.750 0.002 GO:0009966 BP 1 regulation of signal transduction 1 P98170,O43464,Q96P09 289 2.51e-02 14 4 1 0.250 0.071 REAC:5213460 rea 1 RIPK1-mediated regulated necrosis 1 P98170 289 2.51e-02 14 4 1 0.250 0.071 REAC:5218859 rea 1 Regulated Necrosis 1 P98170 289 2.65e-02 28 4 1 0.250 0.036 GO:0071300 BP 1 cellular response to retinoic acid 1 O43464 289 2.78e-02 1635 4 3 0.750 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 P98170,O43464,P55211 289 2.83e-02 1644 4 3 0.750 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 P98170,O43464,P55211 289 2.84e-02 30 4 1 0.250 0.033 GO:0070423 BP 1 nucleotide-binding oligomerization domain containing signaling pathway 1 P98170 289 2.93e-02 31 4 1 0.250 0.032 GO:0035872 BP 1 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 1 P98170 289 2.93e-02 31 4 1 0.250 0.032 GO:0008631 BP 1 intrinsic apoptotic signaling pathway in response to oxidative stress 1 O43464 289 3.07e-02 1691 4 3 0.750 0.002 GO:0010646 BP 1 regulation of cell communication 1 P98170,O43464,Q96P09 289 3.07e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 P98170,O43464,P55211,Q96P09 289 3.13e-02 519 4 2 0.500 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 O43464,P55211 289 3.22e-02 34 4 1 0.250 0.029 GO:1903201 BP 1 regulation of oxidative stress-induced cell death 1 O43464 289 3.22e-02 34 4 1 0.250 0.029 GO:0030510 BP 1 regulation of BMP signaling pathway 1 P98170 289 3.22e-02 34 4 1 0.250 0.029 GO:1903146 BP 1 regulation of mitophagy 1 O43464 289 3.27e-02 1728 4 3 0.750 0.002 GO:0023051 BP 1 regulation of signaling 1 P98170,O43464,Q96P09 289 3.36e-02 1745 4 3 0.750 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 P98170,O43464,P55211 289 3.51e-02 3882 4 4 1.000 0.001 GO:0016043 BP 1 cellular component organization 1 P98170,O43464,P55211,Q96P09 289 3.59e-02 38 4 1 0.250 0.026 GO:0017124 MF 1 SH3 domain binding 1 P55211 289 3.69e-02 39 4 1 0.250 0.026 GO:0032526 BP 1 response to retinoic acid 1 O43464 289 3.75e-02 570 4 2 0.500 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 P98170,Q96P09 289 3.77e-02 42 4 1 0.250 0.024 KEGG:05134 keg 1 Legionellosis 1 P55211 289 3.77e-02 572 4 2 0.500 0.003 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 P98170,Q96P09 289 3.78e-02 40 4 1 0.250 0.025 GO:1900407 BP 1 regulation of cellular response to oxidative stress 1 O43464 289 3.94e-02 44 4 1 0.250 0.023 KEGG:05416 keg 1 Viral myocarditis 1 P55211 289 3.97e-02 42 4 1 0.250 0.024 GO:1902882 BP 1 regulation of response to oxidative stress 1 O43464 289 3.97e-02 42 4 1 0.250 0.024 GO:0002753 BP 1 cytoplasmic pattern recognition receptor signaling pathway 1 P98170 289 4.01e-02 4013 4 4 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 P98170,O43464,P55211,Q96P09 289 4.03e-02 4019 4 4 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 P98170,O43464,P55211,Q96P09 289 4.11e-02 23 4 1 0.250 0.043 REAC:5674400 rea 1 Constitutive Signaling by AKT1 E17K in Cancer 1 P55211 289 4.11e-02 23 4 1 0.250 0.043 REAC:5357769 rea 1 Caspase activation via extrinsic apoptotic signalig pathway 1 P55211 289 4.11e-02 23 4 1 0.250 0.043 REAC:5357956 rea 1 TNFR1-induced NFkappaB signaling pathway 1 P98170 289 4.16e-02 44 4 1 0.250 0.023 GO:0036473 BP 1 cell death in response to oxidative stress 1 O43464 289 4.23e-02 607 4 2 0.500 0.003 GO:0051248 BP 1 negative regulation of protein metabolic process 1 P98170,Q96P09 289 4.30e-02 48 4 1 0.250 0.021 KEGG:05014 keg 1 Amyotrophic lateral sclerosis (ALS) 1 P55211 289 4.38e-02 49 4 1 0.250 0.020 KEGG:05213 keg 1 Endometrial cancer 1 P55211 289 4.63e-02 49 4 1 0.250 0.020 GO:0034644 BP 1 cellular response to UV 1 P55211 289 4.63e-02 49 4 1 0.250 0.020 GO:0005758 CC 1 mitochondrial intermembrane space 1 O43464 289 4.65e-02 52 4 1 0.250 0.019 KEGG:05223 keg 1 Non-small cell lung cancer 1 P55211 289 4.68e-02 1960 4 3 0.750 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P98170,O43464,Q96P09 289 4.68e-02 1960 4 3 0.750 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P98170,O43464,Q96P09 289 4.82e-02 54 4 1 0.250 0.019 KEGG:04370 keg 1 VEGF signaling pathway 1 P55211 289 4.93e-02 657 4 2 0.500 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 P98170,Q96P09 289 5.00e-02 418 4 3 0.750 0.007 TF:M01019_0 tf 1 Factor: Tbx5; motif: NNAGGTGTNANN; match class: 0 1 P98170,O43464,P55211 289 5.00e-02 3 4 1 0.250 0.333 CORUM:5816 cor 1 Apoptosome-procaspase 9 complex 1 P55211 289 5.00e-02 1 4 1 0.250 1.000 HP:0004787 hp 1 Fulminant hepatitis 1 P98170 289 5.00e-02 28 4 1 0.250 0.036 REAC:5357905 rea 1 Regulation of TNFR1 signaling 1 P98170 289 5.00e-02 56 4 1 0.250 0.018 KEGG:04115 keg 1 p53 signaling pathway 1 P55211 289 5.00e-02 53 4 1 0.250 0.019 GO:0031970 CC 1 organelle envelope lumen 1 O43464 289 5.00e-02 17 4 1 0.250 0.059 OMIM:168600 omi 1 Parkinson Disease 1 O43464 289 5.00e-02 1 4 1 0.250 1.000 HP:0002480 hp 1 Hepatic encephalopathy 1 P98170 290 1.42e-03 87 4 2 0.500 0.023 GO:1900542 BP 1 regulation of purine nucleotide metabolic process 1 P51693,Q04656 290 1.48e-03 1 4 1 0.250 1.000 GO:0051542 BP 1 elastin biosynthetic process 1 Q04656 290 1.48e-03 1 4 1 0.250 1.000 GO:0060003 BP 1 copper ion export 1 Q04656 290 1.48e-03 1 4 1 0.250 1.000 GO:0071873 BP 1 response to norepinephrine 1 P51693 290 1.48e-03 1 4 1 0.250 1.000 GO:0035434 BP 1 copper ion transmembrane transport 1 Q04656 290 1.48e-03 1 4 1 0.250 1.000 GO:0071874 BP 1 cellular response to norepinephrine stimulus 1 P51693 290 1.48e-03 1 4 1 0.250 1.000 GO:0031695 MF 1 alpha-2B adrenergic receptor binding 1 P51693 290 1.70e-03 95 4 2 0.500 0.021 GO:0006140 BP 1 regulation of nucleotide metabolic process 1 P51693,Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0061687 BP 1 detoxification of inorganic compound 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0042414 BP 1 epinephrine metabolic process 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0016532 MF 1 superoxide dismutase copper chaperone activity 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0004008 MF 1 copper-exporting ATPase activity 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0021859 BP 1 pyramidal neuron differentiation 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0032767 MF 1 copper-dependent protein binding 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0021860 BP 1 pyramidal neuron development 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0043682 MF 1 copper-transporting ATPase activity 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0097501 BP 1 stress response to metal ion 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:0031696 MF 1 alpha-2C adrenergic receptor binding 1 P51693 290 2.95e-03 2 4 1 0.250 0.500 GO:0010273 BP 1 detoxification of copper ion 1 Q04656 290 2.95e-03 2 4 1 0.250 0.500 GO:1990169 BP 1 stress response to copper ion 1 Q04656 290 4.19e-03 1 4 1 0.250 1.000 OMIM:300489 omi 1 SPINAL MUSCULAR ATROPHY, DISTAL, X-LINKED 3; SMAX3;;SPINAL MUSCULAR ATROPHY, DISTAL, X-LINKED RECESSIVE;;DSMAX 1 Q04656 290 4.19e-03 1 4 1 0.250 1.000 OMIM:304150 omi 1 OCCIPITAL HORN SYNDROME; OHS;;CUTIS LAXA, X-LINKED, FORMERLY;;EHLERS-DANLOS SYNDROME, OCCIPITAL HORN TYPE, FORMERLY;;EDS IX, FORMERLY;;EDS9, FORMERLY 1 Q04656 290 4.19e-03 1 4 1 0.250 1.000 OMIM:309400 omi 1 MENKES DISEASE;;MK; MNK;;MENKES SYNDROME;;KINKY HAIR DISEASE;;STEELY HAIR DISEASE;;COPPER TRANSPORT DISEASE 1 Q04656 290 4.43e-03 3 4 1 0.250 0.333 GO:0021694 BP 1 cerebellar Purkinje cell layer formation 1 Q04656 290 4.43e-03 3 4 1 0.250 0.333 GO:0051541 BP 1 elastin metabolic process 1 Q04656 290 4.43e-03 3 4 1 0.250 0.333 GO:0015677 BP 1 copper ion import 1 Q04656 290 4.43e-03 3 4 1 0.250 0.333 GO:0021702 BP 1 cerebellar Purkinje cell differentiation 1 Q04656 290 4.43e-03 3 4 1 0.250 0.333 GO:0042428 BP 1 serotonin metabolic process 1 Q04656 290 5.26e-03 339 4 2 0.500 0.006 MI:hsa-miR-27b* mi 1 MI:hsa-miR-27b* 1 Q5VT97,P51693 290 5.91e-03 4 4 1 0.250 0.250 GO:0031694 MF 1 alpha-2A adrenergic receptor binding 1 P51693 290 5.91e-03 4 4 1 0.250 0.250 GO:0005375 MF 1 copper ion transmembrane transporter activity 1 Q04656 290 5.91e-03 4 4 1 0.250 0.250 GO:0021697 BP 1 cerebellar cortex formation 1 Q04656 290 5.91e-03 4 4 1 0.250 0.250 GO:0016531 MF 1 copper chaperone activity 1 Q04656 290 6.79e-03 386 4 2 0.500 0.005 MI:hsa-miR-571 mi 1 MI:hsa-miR-571 1 Q5VT97,P51693 290 7.38e-03 5 4 1 0.250 0.200 GO:0042415 BP 1 norepinephrine metabolic process 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0021680 BP 1 cerebellar Purkinje cell layer development 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0048730 BP 1 epidermis morphogenesis 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0016530 MF 1 metallochaperone activity 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:1901160 BP 1 primary amino compound metabolic process 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0048251 BP 1 elastic fiber assembly 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0021692 BP 1 cerebellar Purkinje cell layer morphogenesis 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0021533 BP 1 cell differentiation in hindbrain 1 Q04656 290 7.38e-03 5 4 1 0.250 0.200 GO:0031069 BP 1 hair follicle morphogenesis 1 Q04656 290 8.86e-03 6 4 1 0.250 0.167 GO:0021696 BP 1 cerebellar cortex morphogenesis 1 Q04656 290 8.86e-03 6 4 1 0.250 0.167 GO:0046688 BP 1 response to copper ion 1 Q04656 290 1.03e-02 7 4 1 0.250 0.143 GO:0021587 BP 1 cerebellum morphogenesis 1 Q04656 290 1.03e-02 7 4 1 0.250 0.143 GO:0021695 BP 1 cerebellar cortex development 1 Q04656 290 1.03e-02 7 4 1 0.250 0.143 GO:0048286 BP 1 lung alveolus development 1 Q04656 290 1.18e-02 8 4 1 0.250 0.125 GO:0021575 BP 1 hindbrain morphogenesis 1 Q04656 290 1.18e-02 8 4 1 0.250 0.125 GO:0006878 BP 1 cellular copper ion homeostasis 1 Q04656 290 1.26e-02 3 4 1 0.250 0.333 OMIM:182960 omi 1 Autosomal Recessive Distal Hereditary Motor Neuronopathy (Distal Spinal Muscular Atrophy) 1 Q04656 290 1.33e-02 9 4 1 0.250 0.111 GO:0006568 BP 1 tryptophan metabolic process 1 Q04656 290 1.33e-02 9 4 1 0.250 0.111 GO:0002082 BP 1 regulation of oxidative phosphorylation 1 Q04656 290 1.33e-02 9 4 1 0.250 0.111 GO:0006825 BP 1 copper ion transport 1 Q04656 290 1.39e-02 274 4 2 0.500 0.007 GO:0048471 CC 1 perinuclear region of cytoplasm 1 P51693,Q04656 290 1.48e-02 10 4 1 0.250 0.100 GO:0001974 BP 1 blood vessel remodeling 1 Q04656 290 1.51e-02 286 4 2 0.500 0.007 GO:0043005 CC 1 neuron projection 1 Q92870,Q04656 290 1.62e-02 11 4 1 0.250 0.091 GO:0055070 BP 1 copper ion homeostasis 1 Q04656 290 1.63e-02 297 4 2 0.500 0.007 GO:0008047 MF 1 enzyme activator activity 1 Q5VT97,Q04656 290 1.67e-02 1 4 1 0.250 1.000 HP:0005302 hp 1 Carotid artery tortuosity 1 Q04656 290 1.70e-02 303 4 2 0.500 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P51693,Q04656 290 1.74e-02 307 4 2 0.500 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 P51693,Q04656 290 1.77e-02 12 4 1 0.250 0.083 GO:0022037 BP 1 metencephalon development 1 Q04656 290 1.77e-02 12 4 1 0.250 0.083 GO:0021884 BP 1 forebrain neuron development 1 Q04656 290 1.77e-02 12 4 1 0.250 0.083 GO:0021549 BP 1 cerebellum development 1 Q04656 290 1.77e-02 12 4 1 0.250 0.083 GO:0006586 BP 1 indolalkylamine metabolic process 1 Q04656 290 1.88e-02 319 4 2 0.500 0.006 GO:0019693 BP 1 ribose phosphate metabolic process 1 P51693,Q04656 290 1.92e-02 13 4 1 0.250 0.077 GO:0071450 BP 1 cellular response to oxygen radical 1 Q04656 290 1.92e-02 13 4 1 0.250 0.077 GO:0000303 BP 1 response to superoxide 1 Q04656 290 1.92e-02 13 4 1 0.250 0.077 GO:0071451 BP 1 cellular response to superoxide 1 Q04656 290 1.92e-02 13 4 1 0.250 0.077 GO:0019430 BP 1 removal of superoxide radicals 1 Q04656 290 1.94e-02 324 4 2 0.500 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 P51693,Q04656 290 2.06e-02 14 4 1 0.250 0.071 GO:0030818 BP 1 negative regulation of cAMP biosynthetic process 1 P51693 290 2.06e-02 14 4 1 0.250 0.071 GO:0000305 BP 1 response to oxygen radical 1 Q04656 290 2.06e-02 14 4 1 0.250 0.071 GO:0031690 MF 1 adrenergic receptor binding 1 P51693 290 2.06e-02 14 4 1 0.250 0.071 GO:0042430 BP 1 indole-containing compound metabolic process 1 Q04656 290 2.06e-02 14 4 1 0.250 0.071 GO:0030803 BP 1 negative regulation of cyclic nucleotide biosynthetic process 1 P51693 290 2.21e-02 15 4 1 0.250 0.067 GO:0001942 BP 1 hair follicle development 1 Q04656 290 2.21e-02 15 4 1 0.250 0.067 GO:0098773 BP 1 skin epidermis development 1 Q04656 290 2.21e-02 15 4 1 0.250 0.067 GO:0022405 BP 1 hair cycle process 1 Q04656 290 2.21e-02 15 4 1 0.250 0.067 GO:0042417 BP 1 dopamine metabolic process 1 Q04656 290 2.21e-02 15 4 1 0.250 0.067 GO:0098869 BP 1 cellular oxidant detoxification 1 Q04656 290 2.21e-02 15 4 1 0.250 0.067 GO:0022404 BP 1 molting cycle process 1 Q04656 290 2.25e-02 350 4 2 0.500 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 P51693,Q04656 290 2.36e-02 16 4 1 0.250 0.062 GO:0030800 BP 1 negative regulation of cyclic nucleotide metabolic process 1 P51693 290 2.36e-02 16 4 1 0.250 0.062 GO:0030815 BP 1 negative regulation of cAMP metabolic process 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:0071868 BP 1 cellular response to monoamine stimulus 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:0085029 BP 1 extracellular matrix assembly 1 Q04656 290 2.51e-02 17 4 1 0.250 0.059 GO:0071867 BP 1 response to monoamine 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:1900372 BP 1 negative regulation of purine nucleotide biosynthetic process 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:0071869 BP 1 response to catecholamine 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:0030809 BP 1 negative regulation of nucleotide biosynthetic process 1 P51693 290 2.51e-02 17 4 1 0.250 0.059 GO:0071870 BP 1 cellular response to catecholamine stimulus 1 P51693 290 2.65e-02 18 4 1 0.250 0.056 GO:0001540 MF 1 beta-amyloid binding 1 Q92870 290 2.65e-02 18 4 1 0.250 0.056 GO:1990748 BP 1 cellular detoxification 1 Q04656 290 2.76e-02 388 4 2 0.500 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 P51693,Q04656 290 2.80e-02 19 4 1 0.250 0.053 GO:0030140 CC 1 trans-Golgi network transport vesicle 1 Q04656 290 2.80e-02 19 4 1 0.250 0.053 GO:0021879 BP 1 forebrain neuron differentiation 1 Q04656 290 2.90e-02 398 4 2 0.500 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P51693,Q04656 290 2.95e-02 20 4 1 0.250 0.050 GO:0042093 BP 1 T-helper cell differentiation 1 Q04656 290 2.95e-02 20 4 1 0.250 0.050 GO:0098754 BP 1 detoxification 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0021872 BP 1 forebrain generation of neurons 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0042303 BP 1 molting cycle 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0042633 BP 1 hair cycle 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0002292 BP 1 T cell differentiation involved in immune response 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0006584 BP 1 catecholamine metabolic process 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0002294 BP 1 CD4-positive, alpha-beta T cell differentiation involved in immune response 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0002293 BP 1 alpha-beta T cell differentiation involved in immune response 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0009072 BP 1 aromatic amino acid family metabolic process 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0002287 BP 1 alpha-beta T cell activation involved in immune response 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0030199 BP 1 collagen fibril organization 1 Q04656 290 3.09e-02 21 4 1 0.250 0.048 GO:0009712 BP 1 catechol-containing compound metabolic process 1 Q04656 290 3.12e-02 413 4 2 0.500 0.005 GO:0097458 CC 1 neuron part 1 Q92870,Q04656 290 3.22e-02 4575 4 4 1.000 0.001 HPA:018010_01 hpa 1 hippocampus; glial cells[Uncertain,Low] 1 Q5VT97,P51693,Q92870,Q04656 290 3.24e-02 22 4 1 0.250 0.045 GO:0030902 BP 1 hindbrain development 1 Q04656 290 3.39e-02 23 4 1 0.250 0.043 GO:0021954 BP 1 central nervous system neuron development 1 Q04656 290 3.39e-02 23 4 1 0.250 0.043 GO:0043367 BP 1 CD4-positive, alpha-beta T cell differentiation 1 Q04656 290 3.53e-02 24 4 1 0.250 0.042 GO:0015662 MF 1 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1 Q04656 290 3.53e-02 24 4 1 0.250 0.042 GO:0051353 BP 1 positive regulation of oxidoreductase activity 1 Q04656 290 3.59e-02 444 4 2 0.500 0.005 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P51693,Q04656 290 3.68e-02 25 4 1 0.250 0.040 GO:0046915 MF 1 transition metal ion transmembrane transporter activity 1 Q04656 290 3.68e-02 450 4 2 0.500 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P51693,Q04656 290 3.83e-02 26 4 1 0.250 0.038 GO:1900543 BP 1 negative regulation of purine nucleotide metabolic process 1 P51693 290 3.94e-02 466 4 2 0.500 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P51693,Q04656 290 3.97e-02 27 4 1 0.250 0.037 GO:0035710 BP 1 CD4-positive, alpha-beta T cell activation 1 Q04656 290 3.97e-02 27 4 1 0.250 0.037 GO:0045980 BP 1 negative regulation of nucleotide metabolic process 1 P51693 290 4.12e-02 28 4 1 0.250 0.036 GO:0030324 BP 1 lung development 1 Q04656 290 4.12e-02 28 4 1 0.250 0.036 GO:0006801 BP 1 superoxide metabolic process 1 Q04656 290 4.27e-02 29 4 1 0.250 0.034 GO:0007626 BP 1 locomotory behavior 1 Q04656 290 4.41e-02 30 4 1 0.250 0.033 GO:0030323 BP 1 respiratory tube development 1 Q04656 290 4.41e-02 30 4 1 0.250 0.033 GO:0046632 BP 1 alpha-beta T cell differentiation 1 Q04656 290 4.41e-02 30 4 1 0.250 0.033 GO:0005507 MF 1 copper ion binding 1 Q04656 290 4.56e-02 31 4 1 0.250 0.032 GO:0009118 BP 1 regulation of nucleoside metabolic process 1 Q04656 290 4.56e-02 31 4 1 0.250 0.032 GO:1903578 BP 1 regulation of ATP metabolic process 1 Q04656 290 4.75e-02 5041 4 4 1.000 0.001 HPA:020010_01 hpa 1 lateral ventricle; glial cells[Uncertain,Low] 1 Q5VT97,P51693,Q92870,Q04656 290 4.78e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 Q5VT97,P51693,Q92870,Q04656 290 5.00e-02 27 4 1 0.250 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 Q04656 290 5.00e-02 12 4 1 0.250 0.083 OMIM:104300 omi 1 Alzheimer Disease 1 Q92870 290 5.00e-02 3 4 1 0.250 0.333 HP:0003276 hp 1 Pelvic bone exostoses 1 Q04656 290 5.00e-02 35 4 1 0.250 0.029 KEGG:04978 keg 1 Mineral absorption 1 Q04656 290 5.00e-02 1626 4 4 1.000 0.002 TF:M06119_0 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 0 1 Q5VT97,P51693,Q92870,Q04656 290 5.00e-02 3 4 1 0.250 0.333 HP:0004474 hp 1 Persistent open anterior fontanelle 1 Q04656 290 5.00e-02 3 4 1 0.250 0.333 HP:0000472 hp 1 Long neck 1 Q04656 291 1.09e-07 480 23 10 0.435 0.021 GO:0016491 MF 1 oxidoreductase activity 1 P09211,P00390,P51649,P14550,P51857,P40926,Q9BYZ2,P35754,P11766,C9JRZ8 291 1.89e-07 90 23 6 0.261 0.067 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P14550,P51857,P40926,Q9BYZ2,P11766,C9JRZ8 291 3.17e-07 98 23 6 0.261 0.061 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P14550,P51857,P40926,Q9BYZ2,P11766,C9JRZ8 291 2.54e-06 1333 23 13 0.565 0.010 GO:0044281 BP 1 small molecule metabolic process 1 P54819,P09211,P00390,P51649,P14550,P51857,P00505,P40926,P55263,Q9BYZ2,P35754,Q16831,P11766 291 1.68e-05 2194 23 15 0.652 0.007 GO:0070062 CC 1 extracellular exosome 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 1.79e-05 2205 23 15 0.652 0.007 GO:1903561 CC 1 extracellular vesicle 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 1.79e-05 2205 23 15 0.652 0.007 GO:0043230 CC 1 extracellular organelle 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 5.62e-05 89 23 5 0.217 0.056 REAC:15869 rea 1 Metabolism of nucleotides 1 P54819,P00390,P55263,P35754,Q16831 291 1.78e-04 2627 23 15 0.652 0.006 GO:0044421 CC 1 extracellular region part 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 1.91e-04 26 23 3 0.130 0.115 GO:0015949 BP 1 nucleobase-containing small molecule interconversion 1 P54819,P00390,P35754 291 3.10e-04 2743 23 15 0.652 0.005 GO:0005576 CC 1 extracellular region 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 3.94e-04 2795 23 15 0.652 0.005 GO:0031982 CC 1 vesicle 1 P54819,P09211,P00390,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,Q01469,Q9Y281,P35754,P68036,P11766 291 4.15e-04 5 23 2 0.087 0.400 GO:0015038 MF 1 glutathione disulfide oxidoreductase activity 1 P00390,P35754 291 4.84e-04 344 23 6 0.261 0.017 GO:0005759 CC 1 mitochondrial matrix 1 P00390,P51649,P00505,P40926,Q9BYZ2,C9JRZ8 291 4.87e-04 25 23 3 0.130 0.120 REAC:499943 rea 1 Synthesis and interconversion of nucleotide di- and triphosphates 1 P54819,P00390,P35754 291 6.17e-04 27 23 3 0.130 0.111 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 P09211,P00390,O00244 291 6.21e-04 6 23 2 0.087 0.333 GO:0015037 MF 1 peptide disulfide oxidoreductase activity 1 P00390,P35754 291 6.60e-04 110 23 4 0.174 0.036 GO:0006006 BP 1 glucose metabolic process 1 P51649,P14550,P00505,P40926 291 7.73e-04 2560 23 14 0.609 0.005 GO:0044710 BP 1 single-organism metabolic process 1 P54819,P09211,P00390,P51649,P14550,P51857,P00505,P40926,P55263,Q01469,Q9BYZ2,P35754,Q16831,P11766 291 1.22e-03 1718 23 14 0.609 0.008 REAC:1430728 rea 1 Metabolism 1 P54819,P09211,P00390,P14550,P51857,P00505,P40926,P55263,Q01469,Q9BYZ2,P35754,Q16831,P11766,C9JRZ8 291 1.55e-03 137 23 4 0.174 0.029 GO:0019318 BP 1 hexose metabolic process 1 P51649,P14550,P00505,P40926 291 1.65e-03 4019 23 17 0.739 0.004 GO:0003824 MF 1 catalytic activity 1 P54819,P09211,P00390,P51649,P14550,P51857,P00505,P40926,P21283,P55263,Q9BYZ2,P35754,Q16831,Q969M7,P68036,P11766,C9JRZ8 291 1.73e-03 6993 23 22 0.957 0.003 GO:0005737 CC 1 cytoplasm 1 P54819,P09211,P00390,P51649,P31483,P14550,P51857,P00505,P40926,Q01085,P21283,P55263,Q01469,Q9Y281,Q9BYZ2,P35754,O00244,Q16831,Q969M7,P68036,P11766,C9JRZ8 291 1.73e-03 5629 23 20 0.870 0.004 GO:0044444 CC 1 cytoplasmic part 1 P54819,P09211,P00390,P51649,P31483,P14550,P51857,P00505,P40926,Q01085,P21283,P55263,Q01469,Q9Y281,Q9BYZ2,P35754,O00244,Q16831,P11766,C9JRZ8 291 2.12e-03 650 23 7 0.304 0.011 GO:0019752 BP 1 carboxylic acid metabolic process 1 P09211,P51649,P14550,P51857,P00505,P40926,Q9BYZ2 291 2.65e-03 674 23 7 0.304 0.010 GO:0044429 CC 1 mitochondrial part 1 P54819,P00390,P51649,P00505,P40926,Q9BYZ2,C9JRZ8 291 2.92e-03 64 23 3 0.130 0.047 GO:0043648 BP 1 dicarboxylic acid metabolic process 1 P51649,P00505,P40926 291 3.54e-03 170 23 4 0.174 0.024 GO:0005996 BP 1 monosaccharide metabolic process 1 P51649,P14550,P00505,P40926 291 4.13e-03 72 23 3 0.130 0.042 GO:0009055 MF 1 electron carrier activity 1 P00390,P14550,P11766 291 4.29e-03 729 23 7 0.304 0.010 GO:0043436 BP 1 oxoacid metabolic process 1 P09211,P51649,P14550,P51857,P00505,P40926,Q9BYZ2 291 4.30e-03 15 23 2 0.087 0.133 GO:0005504 MF 1 fatty acid binding 1 Q01469,P11766 291 4.67e-03 739 23 7 0.304 0.009 GO:0006082 BP 1 organic acid metabolic process 1 P09211,P51649,P14550,P51857,P00505,P40926,Q9BYZ2 291 5.56e-03 17 23 2 0.087 0.118 GO:0004029 MF 1 aldehyde dehydrogenase (NAD) activity 1 P51649,P11766 291 6.09e-03 353 23 5 0.217 0.014 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P09211,P51649,P14550,P51857,Q9BYZ2 291 6.19e-03 1029 23 8 0.348 0.008 GO:0005739 CC 1 mitochondrion 1 P54819,P09211,P00390,P51649,P00505,P40926,Q9BYZ2,C9JRZ8 291 6.24e-03 18 23 2 0.087 0.111 GO:0006536 BP 1 glutamate metabolic process 1 P51649,P00505 291 7.74e-03 20 23 2 0.087 0.100 GO:1901687 BP 1 glutathione derivative biosynthetic process 1 P09211,P14550 291 7.74e-03 20 23 2 0.087 0.100 GO:1901685 BP 1 glutathione derivative metabolic process 1 P09211,P14550 291 7.75e-03 572 23 6 0.261 0.010 GO:0044712 BP 1 single-organism catabolic process 1 P51649,P14550,P51857,P00505,Q01469,Q16831 291 8.56e-03 1 23 1 0.043 1.000 HP:0005354 hp 1 Absent cellular immunity 1 P54819 291 9.38e-03 22 23 2 0.087 0.091 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 P14550,P51857 291 1.09e-02 6266 23 20 0.870 0.003 GO:0044763 BP 1 single-organism cellular process 1 P54819,P09211,P00390,P51649,P31483,P14550,P51857,P00505,P60981,P40926,Q01085,P21283,P55263,Q01469,Q9Y281,Q9BYZ2,P35754,O00244,Q16831,P68036 291 1.09e-02 851 23 7 0.304 0.008 GO:0044711 BP 1 single-organism biosynthetic process 1 P09211,P14550,P51857,P00505,P40926,P55263,Q16831 291 1.27e-02 1 23 1 0.043 1.000 OMIM:610687 omi 1 NEMALINE MYOPATHY 7; NEM7 1 Q9Y281 291 1.27e-02 1 23 1 0.043 1.000 OMIM:267500 omi 1 RETICULAR DYSGENESIS;;RETICULAR DYSGENESIA;;CONGENITAL ALEUKIA;;SEVERE COMBINED IMMUNODEFICIENCY WITH LEUKOPENIA;;DE VAAL DISEASE;;HEMATOPOIETIC HYPOPLASIA, GENERALIZED;;ALEUKOCYTOSIS 1 P54819 291 1.27e-02 1 23 1 0.043 1.000 OMIM:235555 omi 1 BILE ACID SYNTHESIS DEFECT, CONGENITAL, 2; CBAS2;;CHOLESTASIS WITH DELTA(4)-3-OXOSTEROID 5-BETA-REDUCTASE DEFICIENCY 1 P51857 291 1.27e-02 1 23 1 0.043 1.000 OMIM:614300 omi 1 HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY 1 P55263 291 1.27e-02 1 23 1 0.043 1.000 OMIM:604454 omi 1 WELANDER DISTAL MYOPATHY; WDM;;MUSCULAR DYSTROPHY, DISTAL, LATE-ONSET, AUTOSOMAL DOMINANT;;MYOPATHY, DISTAL, SWEDISH 1 P31483 291 1.27e-02 1 23 1 0.043 1.000 OMIM:271980 omi 1 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY; SSADHD;;SSADH DEFICIENCY;;4-@HYDROXYBUTYRIC ACIDURIA;;GABA METABOLIC DEFECT;;GAMMA-HYDROXYBUTYRIC ACIDURIA 1 P51649 291 1.31e-02 26 23 2 0.087 0.077 GO:0015036 MF 1 disulfide oxidoreductase activity 1 P00390,P35754 291 1.42e-02 27 23 2 0.087 0.074 GO:0030042 BP 1 actin filament depolymerization 1 P60981,Q9Y281 291 1.42e-02 246 23 4 0.174 0.016 GO:0044282 BP 1 small molecule catabolic process 1 P51649,P14550,P51857,P00505 291 1.64e-02 29 23 2 0.087 0.069 GO:0016620 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1 P51649,P11766 291 1.66e-02 116 23 3 0.130 0.026 GO:0006575 BP 1 cellular modified amino acid metabolic process 1 P09211,P51649,P00505 291 1.70e-02 2 23 1 0.043 0.500 HP:0005541 hp 1 Congenital agranulocytosis 1 P54819 291 1.70e-02 2 23 1 0.043 0.500 HP:0012234 hp 1 Agranulocytosis 1 P54819 291 1.82e-02 450 23 5 0.217 0.011 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P54819,P00390,P55263,P35754,Q16831 291 1.87e-02 31 23 2 0.087 0.065 GO:0010494 CC 1 cytoplasmic stress granule 1 P31483,Q01085 291 2.12e-02 33 23 2 0.087 0.061 GO:0033293 MF 1 monocarboxylic acid binding 1 Q01469,P11766 291 2.18e-02 1 23 1 0.043 1.000 GO:0035732 BP 1 nitric oxide storage 1 P09211 291 2.18e-02 1 23 1 0.043 1.000 GO:0004777 MF 1 succinate-semialdehyde dehydrogenase (NAD+) activity 1 P51649 291 2.18e-02 1 23 1 0.043 1.000 GO:0051903 MF 1 S-(hydroxymethyl)glutathione dehydrogenase activity 1 P11766 291 2.18e-02 1 23 1 0.043 1.000 GO:0035730 MF 1 S-nitrosoglutathione binding 1 P09211 291 2.18e-02 1 23 1 0.043 1.000 GO:0047939 MF 1 L-glucuronate reductase activity 1 P14550 291 2.18e-02 1 23 1 0.043 1.000 GO:0097573 MF 1 glutathione oxidoreductase activity 1 P35754 291 2.18e-02 1 23 1 0.043 1.000 GO:0004362 MF 1 glutathione-disulfide reductase activity 1 P00390 291 2.18e-02 1 23 1 0.043 1.000 GO:0035731 MF 1 dinitrosyl-iron complex binding 1 P09211 291 2.18e-02 1 23 1 0.043 1.000 GO:0035726 BP 1 common myeloid progenitor cell proliferation 1 P09211 291 2.18e-02 1 23 1 0.043 1.000 GO:0006083 BP 1 acetate metabolic process 1 P51649 291 2.18e-02 1 23 1 0.043 1.000 GO:0004001 MF 1 adenosine kinase activity 1 P55263 291 2.18e-02 1 23 1 0.043 1.000 GO:0009013 MF 1 succinate-semialdehyde dehydrogenase [NAD(P)+] activity 1 P51649 291 2.18e-02 1 23 1 0.043 1.000 GO:0080058 BP 1 protein deglutathionylation 1 P35754 291 2.18e-02 1 23 1 0.043 1.000 GO:0018467 MF 1 formaldehyde dehydrogenase activity 1 P11766 291 2.20e-02 277 23 4 0.174 0.014 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 P51649,P14550,P00505,P40926 291 2.52e-02 36 23 2 0.087 0.056 GO:0043094 BP 1 cellular metabolic compound salvage 1 P55263,Q16831 291 2.55e-02 27 23 2 0.087 0.074 REAC:6803529 rea 1 FGFR2 alternative splicing 1 P31483,Q01085 291 3.10e-02 40 23 2 0.087 0.050 GO:0016667 MF 1 oxidoreductase activity, acting on a sulfur group of donors 1 P00390,P35754 291 3.35e-02 31 23 2 0.087 0.065 REAC:156590 rea 1 Glutathione conjugation 1 P09211,P14550 291 3.38e-02 4 23 1 0.043 0.250 HP:0001786 hp 1 Narrow foot 1 P55263 291 3.38e-02 4 23 1 0.043 0.250 HP:0006580 hp 1 Portal fibrosis 1 P55263 291 3.38e-02 4 23 1 0.043 0.250 HP:0002487 hp 1 Hyperkinesis 1 P51649 291 3.41e-02 42 23 2 0.087 0.048 GO:0009064 BP 1 glutamine family amino acid metabolic process 1 P51649,P00505 291 3.41e-02 42 23 2 0.087 0.048 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P51649,P11766 291 3.57e-02 32 23 2 0.087 0.062 REAC:70263 rea 1 Gluconeogenesis 1 P00505,P40926 291 3.74e-02 44 23 2 0.087 0.045 GO:0019205 MF 1 nucleobase-containing compound kinase activity 1 P54819,P55263 291 3.77e-02 3 23 1 0.043 0.333 OMIM:254130 omi 1 Miyoshi Muscular Dystrophy 1 P31483 291 3.88e-02 324 23 4 0.174 0.012 GO:0005975 BP 1 carbohydrate metabolic process 1 P51649,P14550,P00505,P40926 291 4.08e-02 46 23 2 0.087 0.043 GO:0016209 MF 1 antioxidant activity 1 P09211,P00390 291 4.08e-02 46 23 2 0.087 0.043 GO:0006749 BP 1 glutathione metabolic process 1 P09211,P51649 291 4.21e-02 5 23 1 0.043 0.200 HP:0003789 hp 1 Minicore myopathy 1 Q9Y281 291 4.26e-02 47 23 2 0.087 0.043 GO:0034754 BP 1 cellular hormone metabolic process 1 P51857,C9JRZ8 291 4.36e-02 2 23 1 0.043 0.500 GO:0051771 BP 1 negative regulation of nitric-oxide synthase biosynthetic process 1 P09211 291 4.36e-02 2 23 1 0.043 0.500 GO:0006533 BP 1 aspartate catabolic process 1 P00505 291 4.36e-02 2 23 1 0.043 0.500 GO:0097165 CC 1 nuclear stress granule 1 P31483 291 4.36e-02 2 23 1 0.043 0.500 GO:0097057 CC 1 TRAF2-GSTP1 complex 1 P09211 291 4.36e-02 2 23 1 0.043 0.500 GO:0009450 BP 1 gamma-aminobutyric acid catabolic process 1 P51649 291 4.36e-02 2 23 1 0.043 0.500 GO:0009448 BP 1 gamma-aminobutyric acid metabolic process 1 P51649 291 4.36e-02 2 23 1 0.043 0.500 GO:0004069 MF 1 L-aspartate:2-oxoglutarate aminotransferase activity 1 P00505 291 4.36e-02 2 23 1 0.043 0.500 GO:0070026 MF 1 nitric oxide binding 1 P09211 291 4.36e-02 2 23 1 0.043 0.500 GO:0015680 BP 1 intracellular copper ion transport 1 O00244 291 4.36e-02 2 23 1 0.043 0.500 GO:0032767 MF 1 copper-dependent protein binding 1 O00244 291 4.36e-02 2 23 1 0.043 0.500 GO:0033484 BP 1 nitric oxide homeostasis 1 P09211 291 4.36e-02 2 23 1 0.043 0.500 GO:0004850 MF 1 uridine phosphorylase activity 1 Q16831 291 4.40e-02 375 23 3 0.130 0.008 HPA:021020_13 hpa 1 liver; hepatocytes[Supportive,High] 1 P51649,P00505,P40926 291 5.00e-02 3 23 1 0.043 0.333 CORUM:5856 cor 1 AK2-FADD-caspase-10 (AFAC10) complex 1 P54819 291 5.00e-02 2 23 1 0.043 0.500 REAC:916853 rea 1 Degradation of GABA 1 P51649 291 5.00e-02 5209 23 19 0.826 0.004 TF:M07054_0 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 0 1 P54819,P09211,P00390,P51649,P31483,P14550,P51857,P60981,P40926,Q01085,P21283,Q9Y281,P35754,O00244,Q16831,Q969M7,P68036,P11766,C9JRZ8 291 5.00e-02 43 23 3 0.130 0.070 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 P00505,P40926,Q9BYZ2 291 5.00e-02 394 23 5 0.217 0.013 MI:mmu-miR-706 mi 1 MI:mmu-miR-706 1 P00390,P31483,P00505,Q01085,Q16831 291 5.00e-02 3 23 1 0.043 0.333 CORUM:2823 cor 1 BRCA1-BARD1-UbcH7c complex 1 P68036 291 5.00e-02 4 23 1 0.043 0.250 OMIM:607765 omi 1 Congenital Defects in Bile Acid Synthesis 1 P51857 291 5.00e-02 51 23 2 0.087 0.039 GO:0006094 BP 1 gluconeogenesis 1 P00505,P40926 292 1.15e-03 432 2 2 1.000 0.005 TF:M02094_0 tf 1 Factor: ERR3; motif: NNTCAAGGTCACN; match class: 0 1 Q86Y56,Q92990 292 1.35e-03 1 2 1 0.500 1.000 GO:0005171 MF 1 hepatocyte growth factor receptor binding 1 Q92990 292 1.35e-03 1 2 1 0.500 1.000 GO:0045086 BP 1 positive regulation of interleukin-2 biosynthetic process 1 Q92990 292 1.93e-03 1 2 1 0.500 1.000 OMIM:138000 omi 1 GLOMUVENOUS MALFORMATIONS; GVM;;VENOUS MALFORMATIONS WITH GLOMUS CELLS; VMGLOM;;GLOMUS TUMORS, MULTIPLE;;GLOMANGIOMAS, MULTIPLE 1 Q92990 292 1.93e-03 1 2 1 0.500 1.000 OMIM:614874 omi 1 CILIARY DYSKINESIA, PRIMARY, 18; CILD18;;CILIARY DYSKINESIA, PRIMARY, 18, WITH OR WITHOUT SITUS INVERSUS 1 Q86Y56 292 2.71e-03 2 2 1 0.500 0.500 GO:0055105 MF 1 ubiquitin-protein transferase inhibitor activity 1 Q92990 292 4.06e-03 3 2 1 0.500 0.333 GO:0045076 BP 1 regulation of interleukin-2 biosynthetic process 1 Q92990 292 4.87e-03 31 2 1 0.500 0.032 TF:M06248_0 tf 1 Factor: ZNF91; motif: NKGTGARAAAGM; match class: 0 1 Q92990 292 5.41e-03 4 2 1 0.500 0.250 GO:0042094 BP 1 interleukin-2 biosynthetic process 1 Q92990 292 6.62e-03 1036 2 2 1.000 0.002 TF:M01132_0 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 0 1 Q86Y56,Q92990 292 6.62e-03 1036 2 2 1.000 0.002 TF:M07253_0 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 0 1 Q86Y56,Q92990 292 6.77e-03 5 2 1 0.500 0.200 GO:0045505 MF 1 dynein intermediate chain binding 1 Q86Y56 292 6.93e-03 1060 2 2 1.000 0.002 TF:M05427_0 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 0 1 Q86Y56,Q92990 292 8.53e-03 1176 2 2 1.000 0.002 TF:M01261_0 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 0 1 Q86Y56,Q92990 292 8.78e-03 56 2 1 0.500 0.018 TF:M06138_0 tf 1 Factor: ZNF23; motif: NGGTACGGSCTW; match class: 0 1 Q86Y56 292 9.26e-03 1225 2 2 1.000 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 Q86Y56,Q92990 292 1.08e-02 8 2 1 0.500 0.125 GO:0055106 MF 1 ubiquitin-protein transferase regulator activity 1 Q92990 292 1.11e-02 1339 2 2 1.000 0.001 TF:M03925_1 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 1 Q86Y56,Q92990 292 1.35e-02 86 2 1 0.500 0.012 TF:M00123_1 tf 1 Factor: c-Myc:Max; motif: NANCACGTGNNW; match class: 1 1 Q86Y56 292 1.35e-02 10 2 1 0.500 0.100 GO:0031462 CC 1 Cul2-RING ubiquitin ligase complex 1 Q92990 292 1.35e-02 10 2 1 0.500 0.100 GO:0031464 CC 1 Cul4A-RING E3 ubiquitin ligase complex 1 Q92990 292 1.35e-02 10 2 1 0.500 0.100 GO:0036159 BP 1 inner dynein arm assembly 1 Q86Y56 292 1.49e-02 11 2 1 0.500 0.091 GO:0032743 BP 1 positive regulation of interleukin-2 production 1 Q92990 292 1.50e-02 96 2 1 0.500 0.010 TF:M07120_0 tf 1 Factor: Oct-2; motif: NNNATTTGCATRT; match class: 0 1 Q92990 292 1.53e-02 98 2 1 0.500 0.010 TF:M06739_0 tf 1 Factor: ZNF358; motif: NTRTGAAGAATM; match class: 0 1 Q86Y56 292 1.62e-02 12 2 1 0.500 0.083 GO:0036158 BP 1 outer dynein arm assembly 1 Q86Y56 292 1.76e-02 13 2 1 0.500 0.077 GO:0042130 BP 1 negative regulation of T cell proliferation 1 Q92990 292 1.87e-02 1739 2 2 1.000 0.001 TF:M07042_1 tf 1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 1 Q86Y56,Q92990 292 1.90e-02 1755 2 2 1.000 0.001 TF:M00292_0 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 0 1 Q86Y56,Q92990 292 2.03e-02 15 2 1 0.500 0.067 GO:0032945 BP 1 negative regulation of mononuclear cell proliferation 1 Q92990 292 2.03e-02 15 2 1 0.500 0.067 GO:0050672 BP 1 negative regulation of lymphocyte proliferation 1 Q92990 292 2.11e-02 1849 2 2 1.000 0.001 TF:M00193_1 tf 1 Factor: NF-1; motif: NNTTGGCNNNNNNCCNNN; match class: 1 1 Q86Y56,Q92990 292 2.11e-02 135 2 1 0.500 0.007 TF:M01013_1 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 1 1 Q92990 292 2.30e-02 17 2 1 0.500 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 Q92990 292 2.35e-02 1951 2 2 1.000 0.001 TF:M01267_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 Q86Y56,Q92990 292 2.35e-02 1951 2 2 1.000 0.001 TF:M00926_0 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 0 1 Q86Y56,Q92990 292 2.41e-02 154 2 1 0.500 0.006 TF:M07384_1 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 1 1 Q86Y56 292 2.50e-02 2012 2 2 1.000 0.001 TF:M01014_1 tf 1 Factor: SOX; motif: CTCTTTGTTANGA; match class: 1 1 Q86Y56,Q92990 292 2.57e-02 19 2 1 0.500 0.053 GO:0032663 BP 1 regulation of interleukin-2 production 1 Q92990 292 2.64e-02 2070 2 2 1.000 0.001 TF:M03553_0 tf 1 Factor: KLF3; motif: CCMCACCCNG; match class: 0 1 Q86Y56,Q92990 292 2.67e-02 171 2 1 0.500 0.006 TF:M00926_1 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 1 1 Q92990 292 2.67e-02 171 2 1 0.500 0.006 TF:M01267_1 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 1 1 Q92990 292 2.70e-02 20 2 1 0.500 0.050 GO:0042108 BP 1 positive regulation of cytokine biosynthetic process 1 Q92990 292 2.72e-02 2098 2 2 1.000 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q86Y56,Q92990 292 2.73e-02 2104 2 2 1.000 0.001 TF:M02098_0 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 0 1 Q86Y56,Q92990 292 2.96e-02 2189 2 2 1.000 0.001 TF:M00322_0 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 0 1 Q86Y56,Q92990 292 2.97e-02 22 2 1 0.500 0.045 GO:0070286 BP 1 axonemal dynein complex assembly 1 Q86Y56 292 2.97e-02 22 2 1 0.500 0.045 GO:0032623 BP 1 interleukin-2 production 1 Q92990 292 3.11e-02 23 2 1 0.500 0.043 GO:0045502 MF 1 dynein binding 1 Q86Y56 292 3.27e-02 210 2 1 0.500 0.005 TF:M06245_0 tf 1 Factor: ZNF763; motif: NGAATAAGCCNT; match class: 0 1 Q92990 292 3.38e-02 25 2 1 0.500 0.040 GO:0080008 CC 1 Cul4-RING E3 ubiquitin ligase complex 1 Q92990 292 3.38e-02 25 2 1 0.500 0.040 GO:0050868 BP 1 negative regulation of T cell activation 1 Q92990 292 3.45e-02 2365 2 2 1.000 0.001 TF:M00925_0 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 0 1 Q86Y56,Q92990 292 3.52e-02 226 2 1 0.500 0.004 TF:M00925_1 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 1 1 Q92990 292 3.56e-02 27 2 1 0.500 0.037 HP:0005938 hp 1 Abnormal respiratory motile cilium morphology 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012255 hp 1 Dynein arm defect of respiratory motile cilia 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012257 hp 1 Absent inner dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012259 hp 1 Absent inner and outer dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0200106 hp 1 Absent/shortened dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012256 hp 1 Absent outer dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012267 hp 1 Absent respiratory ciliary axoneme radial spokes 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012258 hp 1 Abnormal axonemal organization of respiratory motile cilia 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0200108 hp 1 Shortened outer dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012253 hp 1 Abnormal respiratory epithelium morphology 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0012260 hp 1 Abnormal central microtubular pair morphology of respiratory motile cilia 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0200109 hp 1 Absent/shortened outer dynein arms 1 Q86Y56 292 3.56e-02 27 2 1 0.500 0.037 HP:0200073 hp 1 Respiratory insufficiency due to defective ciliary clearance 1 Q86Y56 292 3.64e-02 2428 2 2 1.000 0.001 TF:M02093_0 tf 1 Factor: ERR1; motif: CAAGGTCAMNN; match class: 0 1 Q86Y56,Q92990 292 3.65e-02 27 2 1 0.500 0.037 GO:0001570 BP 1 vasculogenesis 1 Q92990 292 3.65e-02 27 2 1 0.500 0.037 GO:1903038 BP 1 negative regulation of leukocyte cell-cell adhesion 1 Q92990 292 3.69e-02 28 2 1 0.500 0.036 HP:0012208 hp 1 Nonmotile sperm 1 Q86Y56 292 3.69e-02 28 2 1 0.500 0.036 HP:0012265 hp 1 Ciliary dyskinesia 1 Q86Y56 292 3.74e-02 2461 2 2 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q86Y56,Q92990 292 3.87e-02 249 2 1 0.500 0.004 TF:M02098_1 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 1 1 Q92990 292 3.87e-02 249 2 1 0.500 0.004 TF:M07105_0 tf 1 Factor: JunD; motif: NNNRATGAYGTCATN; match class: 0 1 Q86Y56 292 3.89e-02 250 2 1 0.500 0.004 TF:M00464_0 tf 1 Factor: POU3F2; motif: TTATGYTAAT; match class: 0 1 Q92990 292 3.95e-02 30 2 1 0.500 0.033 HP:0012206 hp 1 Abnormal sperm motility 1 Q86Y56 292 3.95e-02 30 2 1 0.500 0.033 HP:0012207 hp 1 Reduced sperm motility 1 Q86Y56 292 4.08e-02 31 2 1 0.500 0.032 HP:0002257 hp 1 Chronic rhinitis 1 Q86Y56 292 4.08e-02 31 2 1 0.500 0.032 HP:0012735 hp 1 Cough 1 Q86Y56 292 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 Q86Y56 292 4.15e-02 267 2 1 0.500 0.004 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 Q86Y56 292 4.15e-02 267 2 1 0.500 0.004 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 Q86Y56 292 4.26e-02 274 2 1 0.500 0.004 TF:M04313_1 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 1 1 Q92990 292 4.35e-02 33 2 1 0.500 0.030 HP:0100582 hp 1 Nasal polyposis 1 Q86Y56 292 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 Q86Y56,Q92990 292 4.43e-02 285 2 1 0.500 0.004 TF:M00257_0 tf 1 Factor: RREB-1; motif: CCCCAAACMMCCCC; match class: 0 1 Q86Y56 292 4.46e-02 287 2 1 0.500 0.003 TF:M04416_1 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 1 1 Q92990 292 4.46e-02 287 2 1 0.500 0.003 TF:M04381_1 tf 1 Factor: ISX; motif: NYAATTAN; match class: 1 1 Q92990 292 4.46e-02 33 2 1 0.500 0.030 GO:0003341 BP 1 cilium movement 1 Q86Y56 292 4.46e-02 33 2 1 0.500 0.030 GO:0051250 BP 1 negative regulation of lymphocyte activation 1 Q92990 292 4.48e-02 34 2 1 0.500 0.029 HP:0012384 hp 1 Rhinitis 1 Q86Y56 292 4.48e-02 34 2 1 0.500 0.029 HP:0000389 hp 1 Chronic otitis media 1 Q86Y56 292 4.51e-02 2702 2 2 1.000 0.001 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 Q86Y56,Q92990 292 4.61e-02 35 2 1 0.500 0.029 HP:0004469 hp 1 Chronic bronchitis 1 Q86Y56 292 4.61e-02 35 2 1 0.500 0.029 HP:0002688 hp 1 Absent frontal sinuses 1 Q86Y56 292 4.61e-02 35 2 1 0.500 0.029 HP:0011109 hp 1 Chronic sinusitis 1 Q86Y56 292 4.73e-02 35 2 1 0.500 0.029 GO:0035082 BP 1 axoneme assembly 1 Q86Y56 292 4.74e-02 36 2 1 0.500 0.028 HP:0002687 hp 1 Abnormality of frontal sinus 1 Q86Y56 292 4.74e-02 36 2 1 0.500 0.028 HP:0001748 hp 1 Polysplenia 1 Q86Y56 292 4.74e-02 36 2 1 0.500 0.028 HP:0000433 hp 1 Abnormality of the nasal mucosa 1 Q86Y56 292 4.74e-02 36 2 1 0.500 0.028 HP:0009119 hp 1 Aplasia/Hypoplasia of the frontal sinuses 1 Q86Y56 292 4.77e-02 307 2 1 0.500 0.003 TF:M04385_1 tf 1 Factor: LHX2; motif: NCTAATTANN; match class: 1 1 Q92990 292 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 Q86Y56 292 4.84e-02 312 2 1 0.500 0.003 TF:M07221_0 tf 1 Factor: NF-kappaB1; motif: KGGRNTTTCCM; match class: 0 1 Q86Y56 292 4.87e-02 36 2 1 0.500 0.028 GO:0042035 BP 1 regulation of cytokine biosynthetic process 1 Q92990 292 4.95e-02 2831 2 2 1.000 0.001 TF:M01273_0 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 0 1 Q86Y56,Q92990 292 5.00e-02 371 2 2 1.000 0.005 MI:hsa-miR-653 mi 1 MI:hsa-miR-653 1 Q86Y56,Q92990 292 5.00e-02 37 2 1 0.500 0.027 GO:0002695 BP 1 negative regulation of leukocyte activation 1 Q92990 292 5.00e-02 4 2 1 0.500 0.250 CORUM:1258 cor 1 Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1) 1 Q92990 292 5.00e-02 38 2 1 0.500 0.026 HP:0009120 hp 1 Aplasia/Hypoplasia involving the sinuses 1 Q86Y56 292 5.00e-02 26 2 1 0.500 0.038 OMIM:244400 omi 1 Primary Ciliary Dyskinesia 1 Q86Y56 293 4.00e-05 26 2 2 1.000 0.077 KEGG:04710 keg 1 Circadian rhythm 1 P56645,Q49AN0 293 8.68e-05 57 2 2 1.000 0.035 GO:0042752 BP 1 regulation of circadian rhythm 1 P56645,Q49AN0 293 2.53e-04 97 2 2 1.000 0.021 GO:0007623 BP 1 circadian rhythm 1 P56645,Q49AN0 293 3.75e-04 118 2 2 1.000 0.017 GO:0048511 BP 1 rhythmic process 1 P56645,Q49AN0 293 6.27e-04 1 2 1 0.500 1.000 GO:0045187 BP 1 regulation of circadian sleep/wake cycle, sleep 1 P56645 293 6.27e-04 1 2 1 0.500 1.000 GO:0000719 BP 1 photoreactive repair 1 Q49AN0 293 6.27e-04 1 2 1 0.500 1.000 GO:0050802 BP 1 circadian sleep/wake cycle, sleep 1 P56645 293 1.25e-03 2 2 1 0.500 0.500 GO:0003914 MF 1 DNA (6-4) photolyase activity 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0030431 BP 1 sleep 1 P56645 293 1.25e-03 2 2 1 0.500 0.500 GO:0003904 MF 1 deoxyribodipyrimidine photo-lyase activity 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0006290 BP 1 pyrimidine dimer repair 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0009637 BP 1 response to blue light 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0044341 BP 1 sodium-dependent phosphate transport 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0009882 MF 1 blue light photoreceptor activity 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0009785 BP 1 blue light signaling pathway 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0042749 BP 1 regulation of circadian sleep/wake cycle 1 P56645 293 1.25e-03 2 2 1 0.500 0.500 GO:0042745 BP 1 circadian sleep/wake cycle 1 P56645 293 1.25e-03 2 2 1 0.500 0.500 GO:0003913 MF 1 DNA photolyase activity 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:2000118 BP 1 regulation of sodium-dependent phosphate transport 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0071483 BP 1 cellular response to blue light 1 Q49AN0 293 1.25e-03 2 2 1 0.500 0.500 GO:0022410 BP 1 circadian sleep/wake cycle process 1 P56645 293 1.25e-03 2 2 1 0.500 0.500 GO:0010966 BP 1 regulation of phosphate transport 1 Q49AN0 293 3.14e-03 5 2 1 0.500 0.200 GO:0006817 BP 1 phosphate ion transport 1 Q49AN0 293 3.76e-03 6 2 1 0.500 0.167 GO:2000322 BP 1 regulation of glucocorticoid receptor signaling pathway 1 Q49AN0 293 3.76e-03 6 2 1 0.500 0.167 GO:2000323 BP 1 negative regulation of glucocorticoid receptor signaling pathway 1 Q49AN0 293 3.81e-03 375 2 2 1.000 0.005 GO:0000122 BP 1 negative regulation of transcription from RNA polymerase II promoter 1 P56645,Q49AN0 293 4.39e-03 7 2 1 0.500 0.143 GO:0009881 MF 1 photoreceptor activity 1 Q49AN0 293 5.02e-03 8 2 1 0.500 0.125 GO:0042754 BP 1 negative regulation of circadian rhythm 1 Q49AN0 293 5.64e-03 9 2 1 0.500 0.111 GO:0048512 BP 1 circadian behavior 1 P56645 293 5.64e-03 9 2 1 0.500 0.111 GO:0007622 BP 1 rhythmic behavior 1 P56645 293 7.52e-03 12 2 1 0.500 0.083 GO:0050795 BP 1 regulation of behavior 1 P56645 293 7.52e-03 12 2 1 0.500 0.083 GO:0042921 BP 1 glucocorticoid receptor signaling pathway 1 Q49AN0 293 7.52e-03 12 2 1 0.500 0.083 GO:0071949 MF 1 FAD binding 1 Q49AN0 293 7.52e-03 12 2 1 0.500 0.083 GO:0031958 BP 1 corticosteroid receptor signaling pathway 1 Q49AN0 293 8.15e-03 13 2 1 0.500 0.077 GO:0032515 BP 1 negative regulation of phosphoprotein phosphatase activity 1 Q49AN0 293 9.40e-03 15 2 1 0.500 0.067 GO:0043153 BP 1 entrainment of circadian clock by photoperiod 1 Q49AN0 293 1.00e-02 16 2 1 0.500 0.062 GO:0009648 BP 1 photoperiodism 1 Q49AN0 293 1.04e-02 619 2 2 1.000 0.003 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 P56645,Q49AN0 293 1.05e-02 623 2 2 1.000 0.003 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 P56645,Q49AN0 293 1.08e-02 632 2 2 1.000 0.003 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 P56645,Q49AN0 293 1.13e-02 18 2 1 0.500 0.056 GO:0035308 BP 1 negative regulation of protein dephosphorylation 1 Q49AN0 293 1.13e-02 18 2 1 0.500 0.056 GO:0009649 BP 1 entrainment of circadian clock 1 Q49AN0 293 1.21e-02 667 2 2 1.000 0.003 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 P56645,Q49AN0 293 1.38e-02 22 2 1 0.500 0.045 GO:0033144 BP 1 negative regulation of intracellular steroid hormone receptor signaling pathway 1 Q49AN0 293 1.54e-02 753 2 2 1.000 0.003 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 P56645,Q49AN0 293 1.57e-02 25 2 1 0.500 0.040 GO:0043666 BP 1 regulation of phosphoprotein phosphatase activity 1 Q49AN0 293 1.59e-02 765 2 2 1.000 0.003 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 P56645,Q49AN0 293 1.71e-02 794 2 2 1.000 0.003 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 P56645,Q49AN0 293 1.83e-02 822 2 2 1.000 0.002 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 P56645,Q49AN0 293 1.89e-02 834 2 2 1.000 0.002 GO:0009890 BP 1 negative regulation of biosynthetic process 1 P56645,Q49AN0 293 1.94e-02 31 2 1 0.500 0.032 GO:0044070 BP 1 regulation of anion transport 1 Q49AN0 293 1.97e-02 852 2 2 1.000 0.002 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 P56645,Q49AN0 293 2.01e-02 861 2 2 1.000 0.002 GO:0010629 BP 1 negative regulation of gene expression 1 P56645,Q49AN0 293 2.13e-02 34 2 1 0.500 0.029 GO:0016830 MF 1 carbon-carbon lyase activity 1 Q49AN0 293 2.50e-02 40 2 1 0.500 0.025 GO:0050660 MF 1 flavin adenine dinucleotide binding 1 Q49AN0 293 2.56e-02 970 2 2 1.000 0.002 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 P56645,Q49AN0 293 2.63e-02 42 2 1 0.500 0.024 GO:0032922 BP 1 circadian regulation of gene expression 1 Q49AN0 293 2.69e-02 43 2 1 0.500 0.023 GO:0033143 BP 1 regulation of intracellular steroid hormone receptor signaling pathway 1 Q49AN0 293 2.69e-02 43 2 1 0.500 0.023 GO:0035304 BP 1 regulation of protein dephosphorylation 1 Q49AN0 293 3.07e-02 49 2 1 0.500 0.020 GO:0003684 MF 1 damaged DNA binding 1 Q49AN0 293 3.17e-02 38 2 1 0.500 0.026 REAC:1368108 rea 1 BMAL1:CLOCK,NPAS2 activates circadian gene expression 1 Q49AN0 293 3.32e-02 53 2 1 0.500 0.019 GO:0010923 BP 1 negative regulation of phosphatase activity 1 Q49AN0 293 3.38e-02 54 2 1 0.500 0.019 GO:0015698 BP 1 inorganic anion transport 1 Q49AN0 293 3.69e-02 59 2 1 0.500 0.017 GO:0035305 BP 1 negative regulation of dephosphorylation 1 Q49AN0 293 3.76e-02 1177 2 2 1.000 0.002 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 P56645,Q49AN0 293 4.00e-02 8 2 1 0.500 0.125 TF:M06233_0 tf 1 Factor: ZNF91; motif: NGGGGGTGCCGA; match class: 0 1 P56645 293 4.00e-02 8 2 1 0.500 0.125 TF:M06068_0 tf 1 Factor: ZNF716; motif: NGGGGRTGYCGM; match class: 0 1 P56645 293 4.21e-02 238 2 1 0.500 0.004 MI:hsa-miR-32* mi 1 MI:hsa-miR-32* 1 P56645 293 4.25e-02 68 2 1 0.500 0.015 GO:0071482 BP 1 cellular response to light stimulus 1 Q49AN0 293 4.38e-02 70 2 1 0.500 0.014 GO:0003697 MF 1 single-stranded DNA binding 1 Q49AN0 293 4.38e-02 70 2 1 0.500 0.014 GO:0010921 BP 1 regulation of phosphatase activity 1 Q49AN0 293 4.66e-02 1310 2 2 1.000 0.002 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 P56645,Q49AN0 293 4.71e-02 1317 2 2 1.000 0.002 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 P56645,Q49AN0 293 4.90e-02 786 2 2 1.000 0.003 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 P56645,Q49AN0 293 5.00e-02 60 2 1 0.500 0.017 REAC:400253 rea 1 Circadian Clock 1 Q49AN0 293 5.00e-02 81 2 1 0.500 0.012 KEGG:04713 keg 1 Circadian entrainment 1 P56645 293 5.00e-02 80 2 1 0.500 0.013 GO:0033500 BP 1 carbohydrate homeostasis 1 Q49AN0 293 5.00e-02 80 2 1 0.500 0.013 GO:0042593 BP 1 glucose homeostasis 1 Q49AN0 293 5.00e-02 794 2 2 1.000 0.003 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 P56645,Q49AN0 293 5.00e-02 4 2 1 0.500 0.250 CORUM:2773 cor 1 Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) 1 Q49AN0 293 5.00e-02 10 2 1 0.500 0.100 TF:M06845_1 tf 1 Factor: ZBTB38; motif: NTYRATGCAMY; match class: 1 1 Q49AN0 294 1.82e-10 6 3 3 1.000 0.500 GO:0071569 BP 1 protein ufmylation 1 O94874,Q96JB5,Q96HY6 294 1.05e-06 5 3 2 0.667 0.400 GO:1990564 BP 1 protein polyufmylation 1 O94874,Q96HY6 294 1.05e-06 5 3 2 0.667 0.400 GO:1990592 BP 1 protein K69-linked ufmylation 1 O94874,Q96HY6 294 8.29e-06 177 3 3 1.000 0.017 GO:1903050 BP 1 regulation of proteolysis involved in cellular protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 1.04e-05 191 3 3 1.000 0.016 GO:1903362 BP 1 regulation of cellular protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 1.37e-05 209 3 3 1.000 0.014 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 O94874,Q96JB5,Q96HY6 294 1.61e-05 18 3 2 0.667 0.111 GO:0033146 BP 1 regulation of intracellular estrogen receptor signaling pathway 1 O94874,Q96HY6 294 2.02e-05 238 3 3 1.000 0.013 GO:0051090 BP 1 regulation of sequence-specific DNA binding transcription factor activity 1 O94874,Q96JB5,Q96HY6 294 2.86e-05 267 3 3 1.000 0.011 GO:0042176 BP 1 regulation of protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 3.03e-05 272 3 3 1.000 0.011 GO:0031329 BP 1 regulation of cellular catabolic process 1 O94874,Q96JB5,Q96HY6 294 4.57e-05 30 3 2 0.667 0.067 GO:0030520 BP 1 intracellular estrogen receptor signaling pathway 1 O94874,Q96HY6 294 6.46e-05 350 3 3 1.000 0.009 GO:0009894 BP 1 regulation of catabolic process 1 O94874,Q96JB5,Q96HY6 294 9.48e-05 43 3 2 0.667 0.047 GO:0033143 BP 1 regulation of intracellular steroid hormone receptor signaling pathway 1 O94874,Q96HY6 294 1.04e-04 45 3 2 0.667 0.044 GO:0032088 BP 1 negative regulation of NF-kappaB transcription factor activity 1 O94874,Q96JB5 294 1.09e-04 417 3 3 1.000 0.007 GO:0030162 BP 1 regulation of proteolysis 1 O94874,Q96JB5,Q96HY6 294 1.46e-04 459 3 3 1.000 0.007 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 1.71e-04 484 3 3 1.000 0.006 GO:0044257 BP 1 cellular protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 2.66e-04 560 3 3 1.000 0.005 GO:0030163 BP 1 protein catabolic process 1 O94874,Q96JB5,Q96HY6 294 2.85e-04 573 3 3 1.000 0.005 GO:0032446 BP 1 protein modification by small protein conjugation 1 O94874,Q96JB5,Q96HY6 294 3.48e-04 82 3 2 0.667 0.024 GO:0043433 BP 1 negative regulation of sequence-specific DNA binding transcription factor activity 1 O94874,Q96JB5 294 4.19e-04 90 3 2 0.667 0.022 GO:0030518 BP 1 intracellular steroid hormone receptor signaling pathway 1 O94874,Q96HY6 294 4.39e-04 662 3 3 1.000 0.005 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 O94874,Q96JB5,Q96HY6 294 4.48e-04 93 3 2 0.667 0.022 GO:0043401 BP 1 steroid hormone mediated signaling pathway 1 O94874,Q96HY6 294 4.77e-04 96 3 2 0.667 0.021 GO:0061136 BP 1 regulation of proteasomal protein catabolic process 1 O94874,Q96HY6 294 5.82e-04 727 3 3 1.000 0.004 GO:0044265 BP 1 cellular macromolecule catabolic process 1 O94874,Q96JB5,Q96HY6 294 6.04e-04 108 3 2 0.667 0.019 GO:0071383 BP 1 cellular response to steroid hormone stimulus 1 O94874,Q96HY6 294 6.04e-04 108 3 2 0.667 0.019 GO:0009755 BP 1 hormone-mediated signaling pathway 1 O94874,Q96HY6 294 6.07e-04 1 3 1 0.333 1.000 GO:1903721 BP 1 positive regulation of I-kappaB phosphorylation 1 Q96HY6 294 6.07e-04 1 3 1 0.333 1.000 GO:1903719 BP 1 regulation of I-kappaB phosphorylation 1 Q96HY6 294 8.36e-04 127 3 2 0.667 0.016 GO:0048545 BP 1 response to steroid hormone 1 O94874,Q96HY6 294 9.87e-04 138 3 2 0.667 0.014 GO:1903052 BP 1 positive regulation of proteolysis involved in cellular protein catabolic process 1 Q96JB5,Q96HY6 294 1.02e-03 876 3 3 1.000 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 O94874,Q96JB5,Q96HY6 294 1.12e-03 147 3 2 0.667 0.014 GO:1903364 BP 1 positive regulation of cellular protein catabolic process 1 Q96JB5,Q96HY6 294 1.21e-03 2 3 1 0.333 0.500 GO:0071568 MF 1 UFM1 transferase activity 1 O94874 294 1.25e-03 937 3 3 1.000 0.003 GO:0006508 BP 1 proteolysis 1 O94874,Q96JB5,Q96HY6 294 1.31e-03 159 3 2 0.667 0.013 GO:0030522 BP 1 intracellular receptor signaling pathway 1 O94874,Q96HY6 294 1.37e-03 967 3 3 1.000 0.003 GO:0031399 BP 1 regulation of protein modification process 1 O94874,Q96JB5,Q96HY6 294 1.82e-03 3 3 1 0.333 0.333 GO:0097371 MF 1 MDM2/MDM4 family protein binding 1 Q96JB5 294 1.87e-03 190 3 2 0.667 0.011 GO:0031396 BP 1 regulation of protein ubiquitination 1 O94874,Q96JB5 294 1.89e-03 191 3 2 0.667 0.010 GO:0045732 BP 1 positive regulation of protein catabolic process 1 Q96JB5,Q96HY6 294 2.07e-03 200 3 2 0.667 0.010 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 Q96JB5,Q96HY6 294 2.25e-03 1141 3 3 1.000 0.003 GO:0044248 BP 1 cellular catabolic process 1 O94874,Q96JB5,Q96HY6 294 2.26e-03 209 3 2 0.667 0.010 GO:1903320 BP 1 regulation of protein modification by small protein conjugation or removal 1 O94874,Q96JB5 294 2.35e-03 1157 3 3 1.000 0.003 GO:0071310 BP 1 cellular response to organic substance 1 O94874,Q96JB5,Q96HY6 294 2.50e-03 220 3 2 0.667 0.009 GO:0071396 BP 1 cellular response to lipid 1 O94874,Q96HY6 294 2.70e-03 1212 3 3 1.000 0.002 GO:0033554 BP 1 cellular response to stress 1 O94874,Q96JB5,Q96HY6 294 2.71e-03 229 3 2 0.667 0.009 GO:0044389 MF 1 ubiquitin-like protein ligase binding 1 Q96JB5,Q96HY6 294 2.90e-03 237 3 2 0.667 0.008 GO:0009896 BP 1 positive regulation of catabolic process 1 Q96JB5,Q96HY6 294 3.10e-03 245 3 2 0.667 0.008 GO:0071407 BP 1 cellular response to organic cyclic compound 1 O94874,Q96HY6 294 3.26e-03 1290 3 3 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 O94874,Q96JB5,Q96HY6 294 3.38e-03 256 3 2 0.667 0.008 GO:0045862 BP 1 positive regulation of proteolysis 1 Q96JB5,Q96HY6 294 3.64e-03 6 3 1 0.333 0.167 GO:0044387 BP 1 negative regulation of protein kinase activity by regulation of protein phosphorylation 1 Q96JB5 294 3.67e-03 1342 3 3 1.000 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 O94874,Q96JB5,Q96HY6 294 3.83e-03 1362 3 3 1.000 0.002 GO:0009056 BP 1 catabolic process 1 O94874,Q96JB5,Q96HY6 294 4.06e-03 1388 3 3 1.000 0.002 GO:0065009 BP 1 regulation of molecular function 1 O94874,Q96JB5,Q96HY6 294 4.11e-03 1394 3 3 1.000 0.002 GO:0010033 BP 1 response to organic substance 1 O94874,Q96JB5,Q96HY6 294 4.37e-03 1423 3 3 1.000 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 O94874,Q96JB5,Q96HY6 294 4.42e-03 293 3 2 0.667 0.007 GO:0033993 BP 1 response to lipid 1 O94874,Q96HY6 294 4.55e-03 1442 3 3 1.000 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.92e-03 309 3 2 0.667 0.006 GO:0014070 BP 1 response to organic cyclic compound 1 O94874,Q96HY6 294 4.98e-03 311 3 2 0.667 0.006 GO:0032870 BP 1 cellular response to hormone stimulus 1 O94874,Q96HY6 294 5.44e-03 325 3 2 0.667 0.006 GO:0010498 BP 1 proteasomal protein catabolic process 1 O94874,Q96HY6 294 5.46e-03 9 3 1 0.333 0.111 GO:0007252 BP 1 I-kappaB phosphorylation 1 Q96HY6 294 5.91e-03 1573 3 3 1.000 0.002 GO:0009966 BP 1 regulation of signal transduction 1 O94874,Q96JB5,Q96HY6 294 6.37e-03 352 3 2 0.667 0.006 GO:0009725 BP 1 response to hormone 1 O94874,Q96HY6 294 6.67e-03 11 3 1 0.333 0.091 GO:0007095 BP 1 mitotic G2 DNA damage checkpoint 1 Q96JB5 294 6.89e-03 1656 3 3 1.000 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 O94874,Q96JB5,Q96HY6 294 6.98e-03 1663 3 3 1.000 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 O94874,Q96JB5,Q96HY6 294 7.03e-03 370 3 2 0.667 0.005 GO:0031400 BP 1 negative regulation of protein modification process 1 O94874,Q96JB5 294 7.21e-03 1681 3 3 1.000 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 7.34e-03 1691 3 3 1.000 0.002 GO:0010646 BP 1 regulation of cell communication 1 O94874,Q96JB5,Q96HY6 294 7.83e-03 1728 3 3 1.000 0.002 GO:0023051 BP 1 regulation of signaling 1 O94874,Q96JB5,Q96HY6 294 7.88e-03 13 3 1 0.333 0.077 GO:1901798 BP 1 positive regulation of signal transduction by p53 class mediator 1 Q96JB5 294 8.37e-03 404 3 2 0.667 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 O94874,Q96JB5 294 8.48e-03 14 3 1 0.333 0.071 GO:0051019 MF 1 mitogen-activated protein kinase binding 1 Q96JB5 294 8.48e-03 14 3 1 0.333 0.071 GO:0030332 MF 1 cyclin binding 1 Q96JB5 294 8.49e-03 1775 3 3 1.000 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 O94874,Q96JB5,Q96HY6 294 8.53e-03 408 3 2 0.667 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 O94874,Q96JB5 294 8.86e-03 416 3 2 0.667 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 O94874,Q96JB5 294 9.85e-03 1865 3 3 1.000 0.002 GO:0006351 BP 1 transcription, DNA-templated 1 O94874,Q96JB5,Q96HY6 294 9.96e-03 1872 3 3 1.000 0.002 GO:0097659 BP 1 nucleic acid-templated transcription 1 O94874,Q96JB5,Q96HY6 294 1.01e-02 1882 3 3 1.000 0.002 GO:0042221 BP 1 response to chemical 1 O94874,Q96JB5,Q96HY6 294 1.02e-02 2342 3 3 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 O94874,Q96JB5,Q96HY6 294 1.03e-02 17 3 1 0.333 0.059 GO:0044818 BP 1 mitotic G2/M transition checkpoint 1 Q96JB5 294 1.08e-02 1923 3 3 1.000 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.09e-02 462 3 2 0.667 0.004 GO:0016567 BP 1 protein ubiquitination 1 O94874,Q96JB5 294 1.10e-02 1614 3 3 1.000 0.002 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 O94874,Q96JB5,Q96HY6 294 1.15e-02 19 3 1 0.333 0.053 GO:0010972 BP 1 negative regulation of G2/M transition of mitotic cell cycle 1 Q96JB5 294 1.17e-02 1976 3 3 1.000 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.18e-02 1980 3 3 1.000 0.002 GO:0032774 BP 1 RNA biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.19e-02 483 3 2 0.667 0.004 GO:1902533 BP 1 positive regulation of intracellular signal transduction 1 Q96JB5,Q96HY6 294 1.20e-02 1994 3 3 1.000 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 O94874,Q96JB5,Q96HY6 294 1.21e-02 20 3 1 0.333 0.050 GO:1902750 BP 1 negative regulation of cell cycle G2/M phase transition 1 Q96JB5 294 1.27e-02 21 3 1 0.333 0.048 GO:0030262 BP 1 apoptotic nuclear changes 1 Q96JB5 294 1.34e-02 2068 3 3 1.000 0.001 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.35e-02 2071 3 3 1.000 0.001 GO:0006950 BP 1 response to stress 1 O94874,Q96JB5,Q96HY6 294 1.39e-02 2090 3 3 1.000 0.001 GO:0009889 BP 1 regulation of biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.39e-02 23 3 1 0.333 0.043 GO:0051059 MF 1 NF-kappaB binding 1 Q96JB5 294 1.41e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 O94874,Q96JB5,Q96HY6 294 1.42e-02 528 3 2 0.667 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 O94874,Q96HY6 294 1.45e-02 534 3 2 0.667 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 O94874,Q96HY6 294 1.51e-02 544 3 2 0.667 0.004 GO:0032880 BP 1 regulation of protein localization 1 O94874,Q96JB5 294 1.56e-02 2173 3 3 1.000 0.001 GO:0010468 BP 1 regulation of gene expression 1 O94874,Q96JB5,Q96HY6 294 1.60e-02 2192 3 3 1.000 0.001 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 O94874,Q96JB5,Q96HY6 294 1.65e-02 570 3 2 0.667 0.004 GO:0044092 BP 1 negative regulation of molecular function 1 O94874,Q96JB5 294 1.66e-02 572 3 2 0.667 0.003 GO:0032269 BP 1 negative regulation of cellular protein metabolic process 1 O94874,Q96JB5 294 1.70e-02 836 3 2 0.667 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 O94874,Q96JB5 294 1.75e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 O94874,Q96JB5,Q96HY6 294 1.76e-02 29 3 1 0.333 0.034 GO:0031572 BP 1 G2 DNA damage checkpoint 1 Q96JB5 294 1.77e-02 2267 3 3 1.000 0.001 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.79e-02 2275 3 3 1.000 0.001 GO:0036211 BP 1 protein modification process 1 O94874,Q96JB5,Q96HY6 294 1.79e-02 2275 3 3 1.000 0.001 GO:0006464 BP 1 cellular protein modification process 1 O94874,Q96JB5,Q96HY6 294 1.82e-02 30 3 1 0.333 0.033 GO:1903363 BP 1 negative regulation of cellular protein catabolic process 1 Q96JB5 294 1.82e-02 432 3 2 0.667 0.005 TF:M00987_0 tf 1 Factor: FOXP1; motif: TTATTTGTRTTKKYTWKTWT; match class: 0 1 Q96JB5,Q96HY6 294 1.86e-02 2305 3 3 1.000 0.001 GO:0019438 BP 1 aromatic compound biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 1.87e-02 607 3 2 0.667 0.003 GO:0051248 BP 1 negative regulation of protein metabolic process 1 O94874,Q96JB5 294 1.87e-02 2310 3 3 1.000 0.001 GO:0018130 BP 1 heterocycle biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 2.00e-02 33 3 1 0.333 0.030 GO:0010389 BP 1 regulation of G2/M transition of mitotic cell cycle 1 Q96JB5 294 2.03e-02 2374 3 3 1.000 0.001 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 2.09e-02 643 3 2 0.667 0.003 GO:0071495 BP 1 cellular response to endogenous stimulus 1 O94874,Q96HY6 294 2.14e-02 650 3 2 0.667 0.003 GO:0031401 BP 1 positive regulation of protein modification process 1 Q96JB5,Q96HY6 294 2.14e-02 2417 3 3 1.000 0.001 GO:0043412 BP 1 macromolecule modification 1 O94874,Q96JB5,Q96HY6 294 2.19e-02 658 3 2 0.667 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 O94874,Q96HY6 294 2.36e-02 39 3 1 0.333 0.026 GO:0006921 BP 1 cellular component disassembly involved in execution phase of apoptosis 1 Q96JB5 294 2.36e-02 39 3 1 0.333 0.026 GO:1902749 BP 1 regulation of cell cycle G2/M phase transition 1 Q96JB5 294 2.47e-02 700 3 2 0.667 0.003 GO:0001932 BP 1 regulation of protein phosphorylation 1 Q96JB5,Q96HY6 294 2.55e-02 712 3 2 0.667 0.003 GO:0009719 BP 1 response to endogenous stimulus 1 O94874,Q96HY6 294 2.69e-02 2174 3 3 1.000 0.001 TF:M04303_0 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 0 1 O94874,Q96JB5,Q96HY6 294 2.72e-02 45 3 1 0.333 0.022 GO:0043407 BP 1 negative regulation of MAP kinase activity 1 Q96JB5 294 2.75e-02 2627 3 3 1.000 0.001 GO:0016070 BP 1 RNA metabolic process 1 O94874,Q96JB5,Q96HY6 294 2.84e-02 2215 3 3 1.000 0.001 TF:M07341_1 tf 1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 1 O94874,Q96JB5,Q96HY6 294 2.90e-02 760 3 2 0.667 0.003 GO:0042325 BP 1 regulation of phosphorylation 1 Q96JB5,Q96HY6 294 2.92e-02 763 3 2 0.667 0.003 GO:0009967 BP 1 positive regulation of signal transduction 1 Q96JB5,Q96HY6 294 2.95e-02 396 3 2 0.667 0.005 MI:mmu-miR-688 mi 1 MI:mmu-miR-688 1 Q96JB5,Q96HY6 294 3.01e-02 2707 3 3 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 3.02e-02 50 3 1 0.333 0.020 GO:0031330 BP 1 negative regulation of cellular catabolic process 1 Q96JB5 294 3.06e-02 403 3 2 0.667 0.005 MI:hsa-miR-181c* mi 1 MI:hsa-miR-181c* 1 Q96JB5,Q96HY6 294 3.18e-02 411 3 2 0.667 0.005 MI:mmu-miR-759 mi 1 MI:mmu-miR-759 1 Q96JB5,Q96HY6 294 3.19e-02 798 3 2 0.667 0.003 GO:0010647 BP 1 positive regulation of cell communication 1 Q96JB5,Q96HY6 294 3.20e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 O94874,Q96JB5,Q96HY6 294 3.21e-02 2305 3 3 1.000 0.001 TF:M00289_1 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 1 O94874,Q96JB5,Q96HY6 294 3.23e-02 2770 3 3 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 3.24e-02 804 3 2 0.667 0.002 GO:0023056 BP 1 positive regulation of signaling 1 Q96JB5,Q96HY6 294 3.38e-02 56 3 1 0.333 0.018 GO:1901800 BP 1 positive regulation of proteasomal protein catabolic process 1 Q96HY6 294 3.46e-02 832 3 2 0.667 0.002 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 Q96JB5,Q96HY6 294 3.56e-02 59 3 1 0.333 0.017 GO:0042177 BP 1 negative regulation of protein catabolic process 1 Q96JB5 294 3.59e-02 2869 3 3 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 O94874,Q96JB5,Q96HY6 294 3.68e-02 61 3 1 0.333 0.016 GO:0097194 BP 1 execution phase of apoptosis 1 Q96JB5 294 3.74e-02 446 3 2 0.667 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 Q96JB5,Q96HY6 294 3.74e-02 62 3 1 0.333 0.016 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 Q96JB5 294 3.74e-02 62 3 1 0.333 0.016 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 Q96JB5 294 3.86e-02 880 3 2 0.667 0.002 GO:0051247 BP 1 positive regulation of protein metabolic process 1 Q96JB5,Q96HY6 294 3.91e-02 885 3 2 0.667 0.002 GO:0019220 BP 1 regulation of phosphate metabolic process 1 Q96JB5,Q96HY6 294 4.01e-02 897 3 2 0.667 0.002 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 Q96JB5,Q96HY6 294 4.04e-02 2489 3 3 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 O94874,Q96JB5,Q96HY6 294 4.06e-02 2990 3 3 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.09e-02 906 3 2 0.667 0.002 GO:0008283 BP 1 cell proliferation 1 O94874,Q96JB5 294 4.09e-02 2997 3 3 1.000 0.001 GO:0080090 BP 1 regulation of primary metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.12e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 O94874,Q96JB5,Q96HY6 294 4.15e-02 3013 3 3 1.000 0.001 GO:0090304 BP 1 nucleic acid metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.19e-02 3022 3 3 1.000 0.001 GO:0031323 BP 1 regulation of cellular metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.22e-02 70 3 1 0.333 0.014 GO:0010921 BP 1 regulation of phosphatase activity 1 Q96JB5 294 4.22e-02 70 3 1 0.333 0.014 GO:0071901 BP 1 negative regulation of protein serine/threonine kinase activity 1 Q96JB5 294 4.24e-02 3033 3 3 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 O94874,Q96JB5,Q96HY6 294 4.33e-02 933 3 2 0.667 0.002 GO:0005783 CC 1 endoplasmic reticulum 1 O94874,Q96HY6 294 4.34e-02 72 3 1 0.333 0.014 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 Q96JB5 294 4.34e-02 3058 3 3 1.000 0.001 GO:0010467 BP 1 gene expression 1 O94874,Q96JB5,Q96HY6 294 4.36e-02 3063 3 3 1.000 0.001 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.47e-02 681 3 2 0.667 0.003 TF:M00927_1 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 1 1 Q96JB5,Q96HY6 294 4.50e-02 490 3 2 0.667 0.004 MI:hsa-miR-513-5p mi 1 MI:hsa-miR-513-5p 1 Q96JB5,Q96HY6 294 4.58e-02 76 3 1 0.333 0.013 GO:0032434 BP 1 regulation of proteasomal ubiquitin-dependent protein catabolic process 1 O94874 294 4.63e-02 1403 3 2 0.667 0.001 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 O94874,Q96JB5 294 4.70e-02 37 3 1 0.333 0.027 TF:M01075_0 tf 1 Factor: PLZF; motif: KTNNWTNGNNGNTAAAGYTTKATYWGTTC; match class: 0 1 O94874 294 4.82e-02 80 3 1 0.333 0.013 GO:0044773 BP 1 mitotic DNA damage checkpoint 1 Q96JB5 294 4.91e-02 3185 3 3 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 O94874,Q96JB5,Q96HY6 294 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 O94874,Q96JB5 294 5.00e-02 2673 3 3 1.000 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 O94874,Q96JB5,Q96HY6 294 5.00e-02 2673 3 3 1.000 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 O94874,Q96JB5,Q96HY6 294 5.00e-02 517 3 2 0.667 0.004 MI:hsa-miR-220c mi 1 MI:hsa-miR-220c 1 Q96JB5,Q96HY6 294 5.00e-02 83 3 1 0.333 0.012 GO:2000060 BP 1 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 Q96JB5 295 8.66e-04 1 3 1 0.333 1.000 GO:1905520 BP 1 positive regulation of presynaptic active zone assembly 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0021684 BP 1 cerebellar granular layer formation 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0099056 CC 1 integral component of presynaptic membrane 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0097117 BP 1 guanylate kinase-associated protein clustering 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:1905518 BP 1 regulation of presynaptic active zone assembly 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0090126 BP 1 protein complex assembly involved in synapse maturation 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:1905608 BP 1 positive regulation of presynapse assembly 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:1990709 BP 1 presynaptic active zone organization 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:1905606 BP 1 regulation of presynapse assembly 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:1904071 BP 1 presynaptic active zone assembly 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0098889 CC 1 intrinsic component of presynaptic membrane 1 Q9ULB1 295 8.66e-04 1 3 1 0.333 1.000 GO:0021707 BP 1 cerebellar granule cell differentiation 1 Q9ULB1 295 1.73e-03 2 3 1 0.333 0.500 GO:0097118 BP 1 neuroligin clustering involved in postsynaptic membrane assembly 1 Q9ULB1 295 1.73e-03 2 3 1 0.333 0.500 GO:0097112 BP 1 gamma-aminobutyric acid receptor clustering 1 Q9ULB1 295 1.73e-03 2 3 1 0.333 0.500 GO:0021683 BP 1 cerebellar granular layer morphogenesis 1 Q9ULB1 295 1.73e-03 2 3 1 0.333 0.500 GO:0021681 BP 1 cerebellar granular layer development 1 Q9ULB1 295 2.60e-03 3 3 1 0.333 0.333 GO:0097114 BP 1 NMDA glutamate receptor clustering 1 Q9ULB1 295 2.60e-03 3 3 1 0.333 0.333 GO:0051490 BP 1 negative regulation of filopodium assembly 1 Q9ULB1 295 2.60e-03 3 3 1 0.333 0.333 GO:0097116 BP 1 gephyrin clustering involved in postsynaptic density assembly 1 Q9ULB1 295 3.06e-03 13 3 1 0.333 0.077 TF:M06056_0 tf 1 Factor: ZNF99; motif: NGTTGAGGTTGM; match class: 0 1 Q9HC38 295 3.46e-03 4 3 1 0.333 0.250 GO:0010996 BP 1 response to auditory stimulus 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0097109 MF 1 neuroligin family protein binding 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0007638 BP 1 mechanosensory behavior 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0097107 BP 1 postsynaptic density assembly 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0021697 BP 1 cerebellar cortex formation 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0098598 BP 1 learned vocalization behavior or vocal learning 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0097091 BP 1 synaptic vesicle clustering 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0098597 BP 1 observational learning 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0031223 BP 1 auditory behavior 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0098596 BP 1 imitative learning 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0042297 BP 1 vocal learning 1 Q9ULB1 295 3.46e-03 4 3 1 0.333 0.250 GO:0033130 MF 1 acetylcholine receptor binding 1 Q9ULB1 295 3.53e-03 15 3 1 0.333 0.067 TF:M05858_1 tf 1 Factor: ZNF625; motif: GTTSGAGTGN; match class: 1 1 Q9Y2V2 295 4.33e-03 5 3 1 0.333 0.200 GO:0097119 BP 1 postsynaptic density protein 95 clustering 1 Q9ULB1 295 4.33e-03 5 3 1 0.333 0.200 GO:0072578 BP 1 neurotransmitter-gated ion channel clustering 1 Q9ULB1 295 4.33e-03 5 3 1 0.333 0.200 GO:1904861 BP 1 excitatory synapse assembly 1 Q9ULB1 295 4.33e-03 5 3 1 0.333 0.200 GO:0021533 BP 1 cell differentiation in hindbrain 1 Q9ULB1 295 4.77e-03 453 3 2 0.667 0.004 MI:hsa-miR-486-5p mi 1 MI:hsa-miR-486-5p 1 Q9HC38,Q9ULB1 295 5.20e-03 6 3 1 0.333 0.167 GO:0097106 BP 1 postsynaptic density organization 1 Q9ULB1 295 5.20e-03 6 3 1 0.333 0.167 GO:0099084 BP 1 postsynaptic specialization organization 1 Q9ULB1 295 5.20e-03 6 3 1 0.333 0.167 GO:0097104 BP 1 postsynaptic membrane assembly 1 Q9ULB1 295 5.20e-03 6 3 1 0.333 0.167 GO:0023041 BP 1 neuronal signal transduction 1 Q9ULB1 295 5.20e-03 6 3 1 0.333 0.167 GO:0021696 BP 1 cerebellar cortex morphogenesis 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0097120 BP 1 receptor localization to synapse 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0021587 BP 1 cerebellum morphogenesis 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0021695 BP 1 cerebellar cortex development 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0090129 BP 1 positive regulation of synapse maturation 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0090128 BP 1 regulation of synapse maturation 1 Q9ULB1 295 6.06e-03 7 3 1 0.333 0.143 GO:0051968 BP 1 positive regulation of synaptic transmission, glutamatergic 1 Q9ULB1 295 6.12e-03 26 3 1 0.333 0.038 TF:M05461_0 tf 1 Factor: ZBTB4; motif: ATTTATGGCAC; match class: 0 1 Q9ULB1 295 6.12e-03 26 3 1 0.333 0.038 TF:M06341_0 tf 1 Factor: ZNF790; motif: NGGTGCAWATGA; match class: 0 1 Q9HC38 295 6.82e-03 29 3 1 0.333 0.034 TF:M05814_0 tf 1 Factor: ZNF605; motif: TGGGAATGGATN; match class: 0 1 Q9HC38 295 6.93e-03 8 3 1 0.333 0.125 GO:2000310 BP 1 regulation of N-methyl-D-aspartate selective glutamate receptor activity 1 Q9ULB1 295 6.93e-03 8 3 1 0.333 0.125 GO:0021575 BP 1 hindbrain morphogenesis 1 Q9ULB1 295 6.93e-03 8 3 1 0.333 0.125 GO:0071625 BP 1 vocalization behavior 1 Q9ULB1 295 6.93e-03 8 3 1 0.333 0.125 GO:0099068 BP 1 postsynapse assembly 1 Q9ULB1 295 6.93e-03 8 3 1 0.333 0.125 GO:0097105 BP 1 presynaptic membrane assembly 1 Q9ULB1 295 7.76e-03 33 3 1 0.333 0.030 TF:M06334_0 tf 1 Factor: ZNF782; motif: NGTTAAAAAASA; match class: 0 1 Q9Y2V2 295 7.79e-03 9 3 1 0.333 0.111 GO:0044295 CC 1 axonal growth cone 1 Q9ULB1 295 7.79e-03 9 3 1 0.333 0.111 GO:0035418 BP 1 protein localization to synapse 1 Q9ULB1 295 7.79e-03 9 3 1 0.333 0.111 GO:0060074 BP 1 synapse maturation 1 Q9ULB1 295 8.37e-03 603 3 2 0.667 0.003 MI:mmu-miR-466f-5p mi 1 MI:mmu-miR-466f-5p 1 Q9Y2V2,Q9ULB1 295 8.66e-03 10 3 1 0.333 0.100 GO:0097090 BP 1 presynaptic membrane organization 1 Q9ULB1 295 8.66e-03 10 3 1 0.333 0.100 GO:0050885 BP 1 neuromuscular process controlling balance 1 Q9ULB1 295 8.91e-03 8 3 1 0.333 0.125 HP:0007064 hp 1 Progressive language deterioration 1 Q9ULB1 295 9.16e-03 39 3 1 0.333 0.026 TF:M05799_0 tf 1 Factor: ZNF605; motif: NTTWTAATACGA; match class: 0 1 Q9HC38 295 9.52e-03 11 3 1 0.333 0.091 GO:0007158 BP 1 neuron cell-cell adhesion 1 Q9ULB1 295 9.98e-03 369 3 2 0.667 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 Q9HC38,Q9ULB1 295 1.04e-02 12 3 1 0.333 0.083 GO:0099054 BP 1 presynapse assembly 1 Q9ULB1 295 1.04e-02 12 3 1 0.333 0.083 GO:0051965 BP 1 positive regulation of synapse assembly 1 Q9ULB1 295 1.04e-02 12 3 1 0.333 0.083 GO:0022037 BP 1 metencephalon development 1 Q9ULB1 295 1.04e-02 12 3 1 0.333 0.083 GO:0021549 BP 1 cerebellum development 1 Q9ULB1 295 1.13e-02 13 3 1 0.333 0.077 GO:0001941 BP 1 postsynaptic membrane organization 1 Q9ULB1 295 1.13e-02 13 3 1 0.333 0.077 GO:0043186 CC 1 P granule 1 Q9Y2V2 295 1.13e-02 13 3 1 0.333 0.077 GO:0060293 CC 1 germ plasm 1 Q9Y2V2 295 1.13e-02 13 3 1 0.333 0.077 GO:0045495 CC 1 pole plasm 1 Q9Y2V2 295 1.13e-02 13 3 1 0.333 0.077 GO:2000311 BP 1 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 1 Q9ULB1 295 1.21e-02 14 3 1 0.333 0.071 GO:2000463 BP 1 positive regulation of excitatory postsynaptic potential 1 Q9ULB1 295 1.30e-02 15 3 1 0.333 0.067 GO:0000177 CC 1 cytoplasmic exosome (RNase complex) 1 Q9Y2V2 295 1.38e-02 59 3 1 0.333 0.017 TF:M04631_1 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 1 1 Q9Y2V2 295 1.38e-02 16 3 1 0.333 0.062 GO:0098815 BP 1 modulation of excitatory postsynaptic potential 1 Q9ULB1 295 1.38e-02 16 3 1 0.333 0.062 GO:0016339 BP 1 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1 Q9ULB1 295 1.47e-02 17 3 1 0.333 0.059 GO:0099601 BP 1 regulation of neurotransmitter receptor activity 1 Q9ULB1 295 1.47e-02 17 3 1 0.333 0.059 GO:1900449 BP 1 regulation of glutamate receptor signaling pathway 1 Q9ULB1 295 1.52e-02 65 3 1 0.333 0.015 TF:M06787_0 tf 1 Factor: ZNF780B; motif: KGTGGAAAAAGM; match class: 0 1 Q9Y2V2 295 1.56e-02 18 3 1 0.333 0.056 GO:0051963 BP 1 regulation of synapse assembly 1 Q9ULB1 295 1.59e-02 68 3 1 0.333 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q9Y2V2 295 1.64e-02 19 3 1 0.333 0.053 GO:0051703 BP 1 intraspecies interaction between organisms 1 Q9ULB1 295 1.64e-02 19 3 1 0.333 0.053 GO:0035176 BP 1 social behavior 1 Q9ULB1 295 1.64e-02 19 3 1 0.333 0.053 GO:0071709 BP 1 membrane assembly 1 Q9ULB1 295 1.73e-02 20 3 1 0.333 0.050 GO:0060079 BP 1 excitatory postsynaptic potential 1 Q9ULB1 295 1.73e-02 20 3 1 0.333 0.050 GO:0044091 BP 1 membrane biogenesis 1 Q9ULB1 295 1.82e-02 21 3 1 0.333 0.048 GO:0050905 BP 1 neuromuscular process 1 Q9ULB1 295 1.82e-02 21 3 1 0.333 0.048 GO:0051705 BP 1 multi-organism behavior 1 Q9ULB1 295 1.86e-02 1032 3 2 0.667 0.002 TF:M07085_0 tf 1 Factor: E2F-6; motif: RGGCGGGARRN; match class: 0 1 Q9Y2V2,Q9ULB1 295 1.90e-02 22 3 1 0.333 0.045 GO:0030902 BP 1 hindbrain development 1 Q9ULB1 295 1.90e-02 22 3 1 0.333 0.045 GO:0005246 MF 1 calcium channel regulator activity 1 Q9ULB1 295 1.90e-02 22 3 1 0.333 0.045 GO:0060078 BP 1 regulation of postsynaptic membrane potential 1 Q9ULB1 295 1.99e-02 23 3 1 0.333 0.043 GO:0043113 BP 1 receptor clustering 1 Q9ULB1 295 1.99e-02 23 3 1 0.333 0.043 GO:0090004 BP 1 positive regulation of establishment of protein localization to plasma membrane 1 Q9ULB1 295 1.99e-02 23 3 1 0.333 0.043 GO:0051966 BP 1 regulation of synaptic transmission, glutamatergic 1 Q9ULB1 295 1.99e-02 23 3 1 0.333 0.043 GO:1905354 CC 1 exoribonuclease complex 1 Q9Y2V2 295 1.99e-02 23 3 1 0.333 0.043 GO:0042734 CC 1 presynaptic membrane 1 Q9ULB1 295 1.99e-02 23 3 1 0.333 0.043 GO:0000178 CC 1 exosome (RNase complex) 1 Q9Y2V2 295 2.08e-02 24 3 1 0.333 0.042 GO:0035249 BP 1 synaptic transmission, glutamatergic 1 Q9ULB1 295 2.13e-02 91 3 1 0.333 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 Q9HC38 295 2.16e-02 25 3 1 0.333 0.040 GO:1904377 BP 1 positive regulation of protein localization to cell periphery 1 Q9ULB1 295 2.16e-02 25 3 1 0.333 0.040 GO:1903078 BP 1 positive regulation of protein localization to plasma membrane 1 Q9ULB1 295 2.18e-02 93 3 1 0.333 0.011 TF:M06674_0 tf 1 Factor: znf587; motif: NGGGRCTGATGA; match class: 0 1 Q9ULB1 295 2.33e-02 27 3 1 0.333 0.037 GO:0051489 BP 1 regulation of filopodium assembly 1 Q9ULB1 295 2.33e-02 27 3 1 0.333 0.037 GO:0099565 BP 1 chemical synaptic transmission, postsynaptic 1 Q9ULB1 295 2.33e-02 27 3 1 0.333 0.037 GO:0030534 BP 1 adult behavior 1 Q9ULB1 295 2.34e-02 100 3 1 0.333 0.010 TF:M06551_0 tf 1 Factor: znf417; motif: NGGGRCTGATGA; match class: 0 1 Q9ULB1 295 2.44e-02 22 3 1 0.333 0.045 HP:0002136 hp 1 Broad-based gait 1 Q9ULB1 295 2.45e-02 105 3 1 0.333 0.010 TF:M01211_1 tf 1 Factor: PARP; motif: YDRGAAAWAS; match class: 1 1 Q9ULB1 295 2.59e-02 30 3 1 0.333 0.033 GO:0007157 BP 1 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1 Q9ULB1 295 2.85e-02 33 3 1 0.333 0.030 GO:0050807 BP 1 regulation of synapse organization 1 Q9ULB1 295 2.85e-02 33 3 1 0.333 0.030 GO:0050806 BP 1 positive regulation of synaptic transmission 1 Q9ULB1 295 2.85e-02 33 3 1 0.333 0.030 GO:0007612 BP 1 learning 1 Q9ULB1 295 2.94e-02 34 3 1 0.333 0.029 GO:0051668 BP 1 localization within membrane 1 Q9ULB1 295 2.94e-02 126 3 1 0.333 0.008 TF:M06518_0 tf 1 Factor: znf383; motif: NAMTCCTGGARM; match class: 0 1 Q9ULB1 295 2.99e-02 27 3 1 0.333 0.037 HP:0002344 hp 1 Progressive neurologic deterioration 1 Q9ULB1 295 3.02e-02 35 3 1 0.333 0.029 GO:0090003 BP 1 regulation of establishment of protein localization to plasma membrane 1 Q9ULB1 295 3.06e-02 131 3 1 0.333 0.008 TF:M03931_0 tf 1 Factor: ZIC3; motif: GACCCCCCGCTGYGN; match class: 0 1 Q9Y2V2 295 3.08e-02 1338 3 2 0.667 0.001 TF:M07054_1 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 1 Q9HC38,Q9ULB1 295 3.10e-02 133 3 1 0.333 0.008 TF:M06516_0 tf 1 Factor: ZNF418; motif: NGGGKAGCCGT; match class: 0 1 Q9Y2V2 295 3.11e-02 36 3 1 0.333 0.028 GO:0050803 BP 1 regulation of synapse structure or activity 1 Q9ULB1 295 3.20e-02 37 3 1 0.333 0.027 GO:0046847 BP 1 filopodium assembly 1 Q9ULB1 295 3.25e-02 1375 3 2 0.667 0.001 TF:M02074_1 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 1 Q9Y2V2,Q9HC38 295 3.28e-02 38 3 1 0.333 0.026 GO:0048306 MF 1 calcium-dependent protein binding 1 Q9ULB1 295 3.48e-02 4156 3 3 1.000 0.001 TF:M02096_0 tf 1 Factor: ipf1; motif: YTAATGN; match class: 0 1 Q9Y2V2,Q9HC38,Q9ULB1 295 3.56e-02 1442 3 2 0.667 0.001 TF:M04470_0 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 0 1 Q9Y2V2,Q9HC38 295 3.56e-02 153 3 1 0.333 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 Q9HC38 295 3.71e-02 43 3 1 0.333 0.023 GO:0003730 MF 1 mRNA 3'-UTR binding 1 Q9Y2V2 295 3.80e-02 44 3 1 0.333 0.023 GO:0007215 BP 1 glutamate receptor signaling pathway 1 Q9ULB1 295 3.86e-02 35 3 1 0.333 0.029 HP:0010808 hp 1 Protruding tongue 1 Q9ULB1 295 3.93e-02 1519 3 2 0.667 0.001 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 Q9Y2V2,Q9ULB1 295 3.95e-02 170 3 1 0.333 0.006 TF:M02021_1 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 1 1 Q9HC38 295 3.98e-02 171 3 1 0.333 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q9HC38 295 4.06e-02 47 3 1 0.333 0.021 GO:0007270 BP 1 neuron-neuron synaptic transmission 1 Q9ULB1 295 4.11e-02 177 3 1 0.333 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q9ULB1 295 4.14e-02 48 3 1 0.333 0.021 GO:1903076 BP 1 regulation of protein localization to plasma membrane 1 Q9ULB1 295 4.14e-02 48 3 1 0.333 0.021 GO:0033267 CC 1 axon part 1 Q9ULB1 295 4.23e-02 49 3 1 0.333 0.020 GO:1904375 BP 1 regulation of protein localization to cell periphery 1 Q9ULB1 295 4.31e-02 50 3 1 0.333 0.020 GO:0030426 CC 1 growth cone 1 Q9ULB1 295 4.37e-02 188 3 1 0.333 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q9ULB1 295 4.40e-02 51 3 1 0.333 0.020 GO:0021953 BP 1 central nervous system neuron differentiation 1 Q9ULB1 295 4.40e-02 40 3 1 0.333 0.025 HP:0002883 hp 1 Hyperventilation 1 Q9ULB1 295 4.41e-02 161 3 1 0.333 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q9HC38 295 4.41e-02 1614 3 2 0.667 0.001 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 Q9Y2V2,Q9ULB1 295 4.49e-02 52 3 1 0.333 0.019 GO:0097060 CC 1 synaptic membrane 1 Q9ULB1 295 4.57e-02 53 3 1 0.333 0.019 GO:1903729 BP 1 regulation of plasma membrane organization 1 Q9ULB1 295 4.57e-02 53 3 1 0.333 0.019 GO:0009612 BP 1 response to mechanical stimulus 1 Q9ULB1 295 4.57e-02 53 3 1 0.333 0.019 GO:0030427 CC 1 site of polarized growth 1 Q9ULB1 295 4.74e-02 2795 3 3 1.000 0.001 GO:0031982 CC 1 vesicle 1 Q9Y2V2,Q9HC38,Q9ULB1 295 4.74e-02 55 3 1 0.333 0.018 GO:2001257 BP 1 regulation of cation channel activity 1 Q9ULB1 295 4.89e-02 1703 3 2 0.667 0.001 TF:M00940_0 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 0 1 Q9Y2V2,Q9ULB1 295 4.89e-02 211 3 1 0.333 0.005 TF:M05594_0 tf 1 Factor: Staf; motif: GTTTACAAACG; match class: 0 1 Q9Y2V2 295 4.91e-02 57 3 1 0.333 0.018 GO:0099106 MF 1 ion channel regulator activity 1 Q9ULB1 295 4.91e-02 57 3 1 0.333 0.018 GO:0007416 BP 1 synapse assembly 1 Q9ULB1 295 5.00e-02 39 3 1 0.333 0.026 REAC:3000171 rea 1 Non-integrin membrane-ECM interactions 1 Q9ULB1 295 5.00e-02 1 3 1 0.333 1.000 OMIM:614332 omi 1 CHROMOSOME 2p16.3 DELETION SYNDROMESCHIZOPHRENIA 17, INCLUDED; SCZD17, INCLUDED 1 Q9ULB1 295 5.00e-02 1 3 1 0.333 1.000 OMIM:614325 omi 1 PITT-HOPKINS-LIKE SYNDROME 2; PTHSL2 1 Q9ULB1 295 5.00e-02 74 3 1 0.333 0.014 KEGG:04514 keg 1 Cell adhesion molecules (CAMs) 1 Q9ULB1 295 5.00e-02 58 3 1 0.333 0.017 GO:0007611 BP 1 learning or memory 1 Q9ULB1 296 3.76e-15 8 8 5 0.625 0.625 GO:0031209 CC 1 SCAR complex 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 1.09e-13 36 8 7 0.875 0.194 REAC:5663213 rea 1 RHO GTPases Activate WASPs and WAVEs 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.90e-12 68 8 6 0.750 0.088 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.90e-12 68 8 6 0.750 0.088 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.90e-12 68 8 6 0.750 0.088 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.27e-12 70 8 6 0.750 0.086 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.48e-12 71 8 6 0.750 0.085 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.45e-12 59 8 7 0.875 0.119 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.52e-11 81 8 7 0.875 0.086 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.75e-10 142 8 6 0.750 0.042 GO:0006909 BP 1 phagocytosis 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.37e-10 165 8 6 0.750 0.036 GO:0038093 BP 1 Fc receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.46e-10 5 8 4 0.500 0.800 CORUM:186 cor 1 Wave-2 complex 1 Q8IZP0,Q9Y6W5,Q8WUW1,Q7L576 296 1.99e-09 212 8 6 0.750 0.028 GO:0007015 BP 1 actin filament organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.23e-09 216 8 6 0.750 0.028 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.90e-09 90 8 5 0.625 0.056 GO:0030027 CC 1 lamellipodium 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 3.71e-09 235 8 6 0.750 0.026 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.47e-09 5 8 3 0.375 0.600 GO:2000601 BP 1 positive regulation of Arp2/3 complex-mediated actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 1.10e-08 117 8 5 0.625 0.043 GO:0008154 BP 1 actin polymerization or depolymerization 1 Q8IZP0,Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.71e-08 303 8 6 0.750 0.020 GO:0002757 BP 1 immune response-activating signal transduction 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.24e-08 317 8 6 0.750 0.019 GO:0002252 BP 1 immune effector process 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.46e-08 322 8 6 0.750 0.019 GO:0002764 BP 1 immune response-regulating signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.24e-08 337 8 6 0.750 0.018 GO:0002253 BP 1 activation of immune response 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.35e-08 354 8 6 0.750 0.017 GO:0006897 BP 1 endocytosis 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.65e-08 358 8 6 0.750 0.017 GO:0030036 BP 1 actin cytoskeleton organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.35e-08 10 8 3 0.375 0.300 GO:0034315 BP 1 regulation of Arp2/3 complex-mediated actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 6.04e-08 54 8 4 0.500 0.074 GO:0030838 BP 1 positive regulation of actin filament polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 7.23e-08 170 8 5 0.625 0.029 GO:0032956 BP 1 regulation of actin cytoskeleton organization 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 7.35e-08 11 8 3 0.375 0.273 GO:0051127 BP 1 positive regulation of actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 7.41e-08 387 8 6 0.750 0.016 GO:0050778 BP 1 positive regulation of immune response 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 8.11e-08 231 8 7 0.875 0.030 REAC:195258 rea 1 RHO GTPase Effectors 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 8.60e-08 176 8 5 0.625 0.028 GO:0031252 CC 1 cell leading edge 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 9.32e-08 175 8 6 0.750 0.034 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 Q96F07,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.19e-07 419 8 6 0.750 0.014 GO:0030029 BP 1 actin filament-based process 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.37e-07 193 8 5 0.625 0.026 GO:0032970 BP 1 regulation of actin filament-based process 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.37e-07 66 8 4 0.500 0.061 GO:0032273 BP 1 positive regulation of protein polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.43e-07 432 8 6 0.750 0.014 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.57e-07 272 8 7 0.875 0.026 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.99e-07 278 8 7 0.875 0.025 REAC:194138 rea 1 Signaling by VEGF 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.16e-07 81 8 4 0.500 0.049 GO:0030833 BP 1 regulation of actin filament polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.38e-07 499 8 6 0.750 0.012 GO:0002684 BP 1 positive regulation of immune system process 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.46e-07 501 8 6 0.750 0.012 GO:0050776 BP 1 regulation of immune response 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.31e-07 19 8 3 0.375 0.158 GO:0016601 BP 1 Rac protein signal transduction 1 Q9NYB9,Q8WUW1,Q7L576 296 4.31e-07 19 8 3 0.375 0.158 GO:0051125 BP 1 regulation of actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 5.52e-07 93 8 4 0.500 0.043 GO:0008064 BP 1 regulation of actin polymerization or depolymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 5.76e-07 94 8 4 0.500 0.043 GO:0030832 BP 1 regulation of actin filament length 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 5.76e-07 94 8 4 0.500 0.043 GO:0030041 BP 1 actin filament polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 5.91e-07 21 8 3 0.375 0.143 GO:0034314 BP 1 Arp2/3 complex-mediated actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 6.53e-07 264 8 5 0.625 0.019 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 6.66e-07 265 8 5 0.625 0.019 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 7.10e-07 99 8 4 0.500 0.040 GO:0032271 BP 1 regulation of protein polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 9.42e-07 593 8 6 0.750 0.010 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.02e-06 25 8 3 0.375 0.120 GO:0048365 MF 1 Rac GTPase binding 1 Q9NYB9,Q8WUW1,Q7L576 296 1.09e-06 110 8 4 0.500 0.036 GO:0051495 BP 1 positive regulation of cytoskeleton organization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.18e-06 338 8 7 0.875 0.021 REAC:194315 rea 1 Signaling by Rho GTPases 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.80e-06 30 8 3 0.375 0.100 GO:0045010 BP 1 actin nucleation 1 Q9NYB9,Q8WUW1,Q7L576 296 1.99e-06 31 8 3 0.375 0.097 GO:0030032 BP 1 lamellipodium assembly 1 Q9Y6W5,Q8WUW1,Q7L576 296 2.31e-06 690 8 6 0.750 0.009 GO:0002682 BP 1 regulation of immune system process 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.11e-06 143 8 4 0.500 0.028 GO:0031334 BP 1 positive regulation of protein complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.47e-06 739 8 6 0.750 0.008 GO:0006955 BP 1 immune response 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.77e-06 150 8 4 0.500 0.027 GO:0051258 BP 1 protein polymerization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 4.03e-06 758 8 6 0.750 0.008 GO:0007010 BP 1 cytoskeleton organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.19e-06 384 8 5 0.625 0.013 GO:0032403 MF 1 protein complex binding 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 5.07e-06 42 8 3 0.375 0.071 GO:0097581 BP 1 lamellipodium organization 1 Q9Y6W5,Q8WUW1,Q7L576 296 5.44e-06 43 8 3 0.375 0.070 GO:0017048 MF 1 Rho GTPase binding 1 Q9NYB9,Q8WUW1,Q7L576 296 7.13e-06 176 8 4 0.500 0.023 GO:0032535 BP 1 regulation of cellular component size 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.32e-05 485 8 5 0.625 0.010 GO:0008092 MF 1 cytoskeletal protein binding 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q7L576 296 1.58e-05 215 8 4 0.500 0.019 GO:0090066 BP 1 regulation of anatomical structure size 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.60e-05 958 8 6 0.750 0.006 GO:0016192 BP 1 vesicle-mediated transport 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.60e-05 504 8 5 0.625 0.010 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.92e-05 2 8 2 0.250 1.000 CORUM:2294 cor 1 ABI1-WASF2 complex 1 Q8IZP0,Q9Y6W5 296 2.03e-05 229 8 4 0.500 0.017 GO:0043254 BP 1 regulation of protein complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.08e-05 9 8 2 0.250 0.222 GO:0010592 BP 1 positive regulation of lamellipodium assembly 1 Q9Y6W5,Q8WUW1 296 3.32e-05 1086 8 6 0.750 0.006 GO:0048584 BP 1 positive regulation of response to stimulus 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.01e-05 1165 8 6 0.750 0.005 GO:0002376 BP 1 immune system process 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.08e-05 1168 8 6 0.750 0.005 GO:1902589 BP 1 single-organism organelle organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.65e-05 12 8 2 0.250 0.167 GO:0070064 MF 1 proline-rich region binding 1 Q9NYB9,Q9UQB8 296 7.42e-05 690 8 5 0.625 0.007 GO:0044877 MF 1 macromolecular complex binding 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 7.78e-05 14 8 2 0.250 0.143 GO:0008093 MF 1 cytoskeletal adaptor activity 1 Q9NYB9,Q9UQB8 296 8.35e-05 707 8 5 0.625 0.007 GO:0033043 BP 1 regulation of organelle organization 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 8.35e-05 707 8 5 0.625 0.007 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 9.62e-05 728 8 5 0.625 0.007 GO:0042995 CC 1 cell projection 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 1.16e-04 17 8 2 0.250 0.118 GO:0010591 BP 1 regulation of lamellipodium assembly 1 Q9Y6W5,Q8WUW1 296 1.16e-04 17 8 2 0.250 0.118 GO:1902745 BP 1 positive regulation of lamellipodium organization 1 Q9Y6W5,Q8WUW1 296 1.21e-04 360 8 4 0.500 0.011 GO:0010638 BP 1 positive regulation of organelle organization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.55e-04 1416 8 6 0.750 0.004 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.67e-04 391 8 4 0.500 0.010 GO:0043623 BP 1 cellular protein complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 2.15e-04 1498 8 6 0.750 0.004 GO:0044765 BP 1 single-organism transport 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.99e-04 27 8 2 0.250 0.074 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q9Y6W5,Q8WUW1 296 3.01e-04 163 8 3 0.375 0.018 GO:0007265 BP 1 Ras protein signal transduction 1 Q9NYB9,Q8WUW1,Q7L576 296 3.34e-04 169 8 3 0.375 0.018 GO:0017016 MF 1 Ras GTPase binding 1 Q9NYB9,Q8WUW1,Q7L576 296 3.77e-04 1652 8 6 0.750 0.004 GO:1902578 BP 1 single-organism localization 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.30e-04 184 8 3 0.375 0.016 GO:0031267 MF 1 small GTPase binding 1 Q9NYB9,Q8WUW1,Q7L576 296 5.06e-04 2707 8 7 0.875 0.003 GO:0005829 CC 1 cytosol 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.58e-04 201 8 3 0.375 0.015 GO:0051020 MF 1 GTPase binding 1 Q9NYB9,Q8WUW1,Q7L576 296 7.79e-04 582 8 4 0.500 0.007 GO:0005912 CC 1 adherens junction 1 Q8IZP0,Q9Y6W5,Q9UQB8,Q7L576 296 8.26e-04 591 8 4 0.500 0.007 GO:0070161 CC 1 anchoring junction 1 Q8IZP0,Q9Y6W5,Q9UQB8,Q7L576 296 8.38e-04 45 8 2 0.250 0.044 GO:0030175 CC 1 filopodium 1 Q8IZP0,Q9NYB9 296 9.18e-04 238 8 3 0.375 0.013 GO:0030031 BP 1 cell projection assembly 1 Q9Y6W5,Q8WUW1,Q7L576 296 1.02e-03 3004 8 7 0.875 0.002 GO:0007165 BP 1 signal transduction 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.09e-03 3033 8 7 0.875 0.002 GO:0048518 BP 1 positive regulation of biological process 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.19e-03 650 8 4 0.500 0.006 GO:0030030 BP 1 cell projection organization 1 Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.29e-03 267 8 3 0.375 0.011 GO:0007264 BP 1 small GTPase mediated signal transduction 1 Q9NYB9,Q8WUW1,Q7L576 296 1.34e-03 271 8 3 0.375 0.011 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 1.40e-03 275 8 3 0.375 0.011 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 1.43e-03 277 8 3 0.375 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 1.44e-03 938 8 7 0.875 0.007 REAC:168249 rea 1 Innate Immune System 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.48e-03 2101 8 6 0.750 0.003 GO:0048583 BP 1 regulation of response to stimulus 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.49e-03 689 8 4 0.500 0.006 GO:0034622 BP 1 cellular macromolecular complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 1.51e-03 282 8 3 0.375 0.011 GO:0045296 MF 1 cadherin binding 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 1.70e-03 294 8 3 0.375 0.010 GO:0005913 CC 1 cell-cell adherens junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 1.77e-03 3262 8 7 0.875 0.002 GO:0007154 BP 1 cell communication 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.79e-03 3268 8 7 0.875 0.002 GO:0044700 BP 1 single organism signaling 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.81e-03 3274 8 7 0.875 0.002 GO:0023052 BP 1 signaling 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.89e-03 2194 8 6 0.750 0.003 GO:0070062 CC 1 extracellular exosome 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.94e-03 2205 8 6 0.750 0.003 GO:1903561 CC 1 extracellular vesicle 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.94e-03 2205 8 6 0.750 0.003 GO:0043230 CC 1 extracellular organelle 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.01e-03 746 8 4 0.500 0.005 GO:0030054 CC 1 cell junction 1 Q8IZP0,Q9Y6W5,Q9UQB8,Q7L576 296 2.24e-03 2262 8 6 0.750 0.003 GO:0006996 BP 1 organelle organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.32e-03 75 8 2 0.250 0.027 GO:0098858 CC 1 actin-based cell projection 1 Q8IZP0,Q9NYB9 296 2.34e-03 3401 8 7 0.875 0.002 GO:0051179 BP 1 localization 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.47e-03 1438 8 5 0.625 0.003 GO:0051128 BP 1 regulation of cellular component organization 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 2.84e-03 83 8 2 0.250 0.024 GO:0051017 BP 1 actin filament bundle assembly 1 Q9Y6W5,Q9UQB8 296 2.91e-03 84 8 2 0.250 0.024 GO:0061572 BP 1 actin filament bundle organization 1 Q9Y6W5,Q9UQB8 296 3.17e-03 842 8 4 0.500 0.005 GO:0006461 BP 1 protein complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.17e-03 842 8 4 0.500 0.005 GO:0070271 BP 1 protein complex biogenesis 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.29e-03 369 8 3 0.375 0.008 GO:0050839 MF 1 cell adhesion molecule binding 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 4.06e-03 4190 8 7 0.875 0.002 TF:M00747_1 tf 1 Factor: IRF-1; motif: TTCACTT; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.51e-03 3755 8 7 0.875 0.002 GO:0051716 BP 1 cellular response to stimulus 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.61e-03 106 8 2 0.250 0.019 GO:0030674 MF 1 protein binding, bridging 1 Q9NYB9,Q9UQB8 296 4.78e-03 420 8 3 0.375 0.007 GO:0005911 CC 1 cell-cell junction 1 Q8IZP0,Q9Y6W5,Q9UQB8 296 4.78e-03 108 8 2 0.250 0.019 GO:0060491 BP 1 regulation of cell projection assembly 1 Q9Y6W5,Q8WUW1 296 5.15e-03 2627 8 6 0.750 0.002 GO:0044421 CC 1 extracellular region part 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.28e-03 6184 8 8 1.000 0.001 TF:M00706_0 tf 1 Factor: TFII-I; motif: RGAGGKAGG; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9P206,Q9UQB8,Q8WUW1,Q7L576 296 5.34e-03 2644 8 6 0.750 0.002 GO:0006810 BP 1 transport 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.44e-03 1706 8 5 0.625 0.003 GO:0022607 BP 1 cellular component assembly 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.89e-03 120 8 2 0.250 0.017 GO:0060090 MF 1 binding, bridging 1 Q9NYB9,Q9UQB8 296 6.38e-03 1015 8 4 0.500 0.004 GO:0071822 BP 1 protein complex subunit organization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 6.54e-03 2743 8 6 0.750 0.002 GO:0005576 CC 1 extracellular region 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 6.60e-03 2748 8 6 0.750 0.002 GO:0051234 BP 1 establishment of localization 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 6.78e-03 2761 8 6 0.750 0.002 GO:0048522 BP 1 positive regulation of cellular process 1 Q96F07,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 7.25e-03 2795 8 6 0.750 0.002 GO:0031982 CC 1 vesicle 1 Q96F07,Q8IZP0,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 8.08e-03 141 8 2 0.250 0.014 GO:0018108 BP 1 peptidyl-tyrosine phosphorylation 1 Q8IZP0,Q9NYB9 296 8.12e-03 171 8 2 0.250 0.012 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q96F07,Q9UQB8 296 8.30e-03 143 8 2 0.250 0.014 GO:0018212 BP 1 peptidyl-tyrosine modification 1 Q8IZP0,Q9NYB9 296 8.88e-03 148 8 2 0.250 0.014 GO:0031346 BP 1 positive regulation of cell projection organization 1 Q9Y6W5,Q8WUW1 296 8.96e-03 1113 8 4 0.500 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 9.58e-03 1932 8 5 0.625 0.003 GO:0044085 BP 1 cellular component biogenesis 1 Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 9.62e-03 9 8 1 0.125 0.111 TF:M05327_0 tf 1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 0 1 Q9NYB9 296 9.92e-03 3376 8 6 0.750 0.002 TF:M07297_0 tf 1 Factor: MAZ; motif: CCCTCCCYCYN; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 1.01e-02 191 8 2 0.250 0.010 TF:M04142_0 tf 1 Factor: TEAD1; motif: RCATTCCWNRCATTCCN; match class: 0 1 Q9P206,Q7L576 296 1.09e-02 199 8 2 0.250 0.010 TF:M06027_0 tf 1 Factor: ZNF891; motif: NNMACAAGGCAA; match class: 0 1 Q9Y6W5,Q9P206 296 1.12e-02 70 8 2 0.250 0.029 KEGG:04520 keg 1 Adherens junction 1 Q9Y6W5,Q9UQB8 296 1.19e-02 4356 8 7 0.875 0.002 GO:0050896 BP 1 response to stimulus 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 1.26e-02 2 8 1 0.125 0.500 CORUM:2297 cor 1 ABI1-WASL complex 1 Q8IZP0 296 1.27e-02 9 8 1 0.125 0.111 GO:0097202 BP 1 activation of cysteine-type endopeptidase activity 1 Q96F07 296 1.27e-02 9 8 1 0.125 0.111 GO:0051764 BP 1 actin crosslink formation 1 Q9UQB8 296 1.28e-02 12 8 1 0.125 0.083 TF:M06400_0 tf 1 Factor: ZNF497; motif: NCSTCCGTCRSA; match class: 0 1 Q7L576 296 1.38e-02 2096 8 5 0.625 0.002 GO:0043234 CC 1 protein complex 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q8WUW1,Q7L576 296 1.41e-02 10 8 1 0.125 0.100 GO:0051497 BP 1 negative regulation of stress fiber assembly 1 Q9Y6W5 296 1.49e-02 5113 8 7 0.875 0.001 TF:M04344_0 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9P206,Q8WUW1,Q7L576 296 1.52e-02 195 8 2 0.250 0.010 GO:0003779 MF 1 actin binding 1 Q9Y6W5,Q7L576 296 1.52e-02 195 8 2 0.250 0.010 GO:0007409 BP 1 axonogenesis 1 Q9UQB8,Q7L576 296 1.52e-02 744 8 3 0.375 0.004 TF:M04417_0 tf 1 Factor: NOTO; motif: NYTAATTANN; match class: 0 1 Q96F07,Q8IZP0,Q9P206 296 1.55e-02 11 8 1 0.125 0.091 GO:0005845 CC 1 mRNA cap binding complex 1 Q7L576 296 1.55e-02 11 8 1 0.125 0.091 GO:0070207 BP 1 protein homotrimerization 1 Q8WUW1 296 1.69e-02 12 8 1 0.125 0.083 GO:0034518 CC 1 RNA cap binding complex 1 Q7L576 296 1.69e-02 12 8 1 0.125 0.083 GO:0032232 BP 1 negative regulation of actin filament bundle assembly 1 Q9Y6W5 296 1.71e-02 2526 8 5 0.625 0.002 TF:M04446_1 tf 1 Factor: VAX1; motif: YTAATTAN; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9P206,Q7L576 296 1.72e-02 208 8 2 0.250 0.010 GO:0061564 BP 1 axon development 1 Q9UQB8,Q7L576 296 1.83e-02 13 8 1 0.125 0.077 GO:2000251 BP 1 positive regulation of actin cytoskeleton reorganization 1 Q9UQB8 296 1.91e-02 808 8 3 0.375 0.004 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 Q96F07,Q9P206,Q9UQB8 296 2.23e-02 288 8 2 0.250 0.007 TF:M07394_1 tf 1 Factor: slug; motif: CACCTGNNN; match class: 1 1 Q96F07,Q9UQB8 296 2.29e-02 241 8 2 0.250 0.008 GO:0048667 BP 1 cell morphogenesis involved in neuron differentiation 1 Q9UQB8,Q7L576 296 2.34e-02 22 8 1 0.125 0.045 TF:M06010_0 tf 1 Factor: ZNF701; motif: NTGGGCANAAGA; match class: 0 1 Q8WUW1 296 2.41e-02 7474 8 8 1.000 0.001 TF:M00974_0 tf 1 Factor: SMAD; motif: TNGNCAGACWN; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9P206,Q9UQB8,Q8WUW1,Q7L576 296 2.48e-02 2749 8 5 0.625 0.002 TF:M04347_1 tf 1 Factor: HOXB2; motif: NNTMATTANN; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9P206,Q7L576 296 2.57e-02 900 8 3 0.375 0.003 TF:M04440_1 tf 1 Factor: SHOX; motif: NYAATTAN; match class: 1 1 Q8IZP0,Q9NYB9,Q9P206 296 2.59e-02 903 8 3 0.375 0.003 TF:M04415_1 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 1 1 Q96F07,Q8IZP0,Q7L576 296 2.67e-02 4062 8 6 0.750 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 2.67e-02 19 8 1 0.125 0.053 GO:0070206 BP 1 protein trimerization 1 Q8WUW1 296 2.86e-02 2840 8 5 0.625 0.002 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9P206,Q9UQB8 296 2.86e-02 384 8 2 0.250 0.005 MI:mmu-miR-293 mi 1 MI:mmu-miR-293 1 Q9NYB9,Q9UQB8 296 2.92e-02 274 8 2 0.250 0.007 GO:0048471 CC 1 perinuclear region of cytoplasm 1 Q96F07,Q7L576 296 2.94e-02 333 8 2 0.250 0.006 TF:M04486_0 tf 1 Factor: RARG; motif: RAGGTCANNNRAGGTCA; match class: 0 1 Q9P206,Q7L576 296 2.95e-02 1457 8 7 0.875 0.005 REAC:168256 rea 1 Immune System 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 3.00e-02 278 8 2 0.250 0.007 GO:0048812 BP 1 neuron projection morphogenesis 1 Q9UQB8,Q7L576 296 3.08e-02 29 8 1 0.125 0.034 TF:M01123_1 tf 1 Factor: Nanog; motif: GGGNCCATTKCC; match class: 1 1 Q9P206 296 3.12e-02 402 8 2 0.250 0.005 MI:hsa-miR-187 mi 1 MI:hsa-miR-187 1 Q9NYB9,Q9UQB8 296 3.28e-02 291 8 2 0.250 0.007 GO:0048858 BP 1 cell projection morphogenesis 1 Q9UQB8,Q7L576 296 3.30e-02 1857 8 4 0.500 0.002 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 Q8IZP0,Q9NYB9,Q9P206,Q9UQB8 296 3.34e-02 1864 8 4 0.500 0.002 TF:M03899_0 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 0 1 Q9NYB9,Q9P206,Q9UQB8,Q7L576 296 3.37e-02 24 8 1 0.125 0.042 GO:0031529 BP 1 ruffle organization 1 Q7L576 296 3.37e-02 24 8 1 0.125 0.042 GO:2000249 BP 1 regulation of actin cytoskeleton reorganization 1 Q9UQB8 296 3.41e-02 999 8 3 0.375 0.003 TF:M04594_0 tf 1 Factor: Zic3; motif: CCCGCTGGG; match class: 0 1 Q9Y6W5,Q9P206,Q7L576 296 3.41e-02 1614 8 4 0.500 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q9NYB9,Q9UQB8,Q8WUW1,Q7L576 296 3.45e-02 299 8 2 0.250 0.007 GO:0032990 BP 1 cell part morphogenesis 1 Q9UQB8,Q7L576 296 3.56e-02 304 8 2 0.250 0.007 GO:0031344 BP 1 regulation of cell projection organization 1 Q9Y6W5,Q8WUW1 296 3.61e-02 306 8 2 0.250 0.007 GO:0015629 CC 1 actin cytoskeleton 1 Q9Y6W5,Q9UQB8 296 3.65e-02 26 8 1 0.125 0.038 GO:0031638 BP 1 zymogen activation 1 Q96F07 296 3.67e-02 3011 8 5 0.625 0.002 TF:M02102_0 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 0 1 Q8IZP0,Q9NYB9,Q9P206,Q8WUW1,Q7L576 296 3.72e-02 35 8 1 0.125 0.029 TF:M04418_0 tf 1 Factor: OTX1; motif: NNTAATCCGATTANN; match class: 0 1 Q7L576 296 3.79e-02 314 8 2 0.250 0.006 GO:0000904 BP 1 cell morphogenesis involved in differentiation 1 Q9UQB8,Q7L576 296 3.80e-02 3035 8 5 0.625 0.002 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9P206,Q9UQB8 296 3.88e-02 3049 8 5 0.625 0.002 TF:M01219_0 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 0 1 Q8IZP0,Q9NYB9,Q9P206,Q9UQB8,Q7L576 296 4.03e-02 38 8 1 0.125 0.026 TF:M06666_0 tf 1 Factor: ZNF442; motif: KGKTTGTGSCGA; match class: 0 1 Q7L576 296 4.10e-02 466 8 2 0.250 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 Q9NYB9,Q9UQB8 296 4.10e-02 4411 8 6 0.750 0.001 TF:M00302_0 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 0 1 Q96F07,Q9NYB9,Q9Y6W5,Q9P206,Q9UQB8,Q7L576 296 4.19e-02 1989 8 4 0.500 0.002 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q8IZP0,Q9NYB9,Q9P206,Q9UQB8 296 4.21e-02 3882 8 6 0.750 0.002 GO:0016043 BP 1 cellular component organization 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 4.22e-02 1994 8 4 0.500 0.002 TF:M00980_1 tf 1 Factor: TBP; motif: TTTATAN; match class: 1 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5 296 4.31e-02 1090 8 3 0.375 0.003 TF:M04387_1 tf 1 Factor: LHX6; motif: RCTAATTARN; match class: 1 1 Q96F07,Q9NYB9,Q9P206 296 4.31e-02 1090 8 3 0.375 0.003 TF:M04387_0 tf 1 Factor: LHX6; motif: RCTAATTARN; match class: 0 1 Q96F07,Q9NYB9,Q9P206 296 4.35e-02 41 8 1 0.125 0.024 TF:M06276_0 tf 1 Factor: ZNF642; motif: KGTAGYGAGATG; match class: 0 1 Q96F07 296 4.49e-02 2030 8 4 0.500 0.002 TF:M03538_0 tf 1 Factor: AP-1; motif: TGACTCAN; match class: 0 1 Q8IZP0,Q9Y6W5,Q8WUW1,Q7L576 296 4.49e-02 2030 8 4 0.500 0.002 TF:M03869_0 tf 1 Factor: Fra-1; motif: TGACTCAN; match class: 0 1 Q8IZP0,Q9Y6W5,Q8WUW1,Q7L576 296 4.49e-02 2030 8 4 0.500 0.002 TF:M03552_0 tf 1 Factor: JunD; motif: TGACTCAN; match class: 0 1 Q8IZP0,Q9Y6W5,Q8WUW1,Q7L576 296 4.50e-02 4492 8 6 0.750 0.001 TF:M00339_0 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 0 1 Q96F07,Q8IZP0,Q9Y6W5,Q9P206,Q9UQB8,Q7L576 296 4.55e-02 420 8 2 0.250 0.005 TF:M05752_0 tf 1 Factor: ZNF57; motif: NCGGGGTGGKSA; match class: 0 1 Q8IZP0,Q9UQB8 296 4.66e-02 3184 8 5 0.625 0.002 TF:M01798_0 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 0 1 Q9NYB9,Q9Y6W5,Q9P206,Q8WUW1,Q7L576 296 4.74e-02 2062 8 4 0.500 0.002 TF:M07052_0 tf 1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 0 1 Q8IZP0,Q9NYB9,Q9P206,Q8WUW1 296 4.76e-02 45 8 1 0.125 0.022 TF:M06639_0 tf 1 Factor: znf559; motif: NGKGCCGACCGC; match class: 0 1 Q9P206 296 4.83e-02 1138 8 3 0.375 0.003 TF:M01593_1 tf 1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 1 1 Q96F07,Q9UQB8,Q7L576 296 4.97e-02 47 8 1 0.125 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 Q9UQB8 296 4.99e-02 6182 8 7 0.875 0.001 TF:M04320_0 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 0 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9P206,Q8WUW1,Q7L576 296 5.00e-02 4013 8 6 0.750 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.00e-02 1575 8 7 0.875 0.004 REAC:162582 rea 1 Signal Transduction 1 Q96F07,Q8IZP0,Q9NYB9,Q9Y6W5,Q9UQB8,Q8WUW1,Q7L576 296 5.00e-02 442 8 2 0.250 0.005 TF:M00616_0 tf 1 Factor: AFP1; motif: ATTAAYTRCAC; match class: 0 1 Q9NYB9,Q7L576 296 5.00e-02 152 8 2 0.250 0.013 KEGG:03013 keg 1 RNA transport 1 Q96F07,Q7L576 296 5.00e-02 8 8 1 0.125 0.125 CORUM:2300 cor 1 Profilin 2 complex 1 Q7L576 297 2.66e-09 51 4 4 1.000 0.078 REAC:216083 rea 1 Integrin cell surface interactions 1 P23229,P05556,P08648,P17301 297 2.41e-08 17 4 3 0.750 0.176 GO:0008305 CC 1 integrin complex 1 P05556,P08648,P17301 297 2.41e-08 17 4 3 0.750 0.176 GO:0098636 CC 1 protein complex involved in cell adhesion 1 P05556,P08648,P17301 297 2.80e-08 63 4 4 1.000 0.063 KEGG:05412 keg 1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1 P23229,P05556,P08648,P17301 297 3.39e-08 66 4 4 1.000 0.061 KEGG:05410 keg 1 Hypertrophic cardiomyopathy (HCM) 1 P23229,P05556,P08648,P17301 297 3.60e-08 67 4 4 1.000 0.060 KEGG:04512 keg 1 ECM-receptor interaction 1 P23229,P05556,P08648,P17301 297 4.57e-08 71 4 4 1.000 0.056 KEGG:05414 keg 1 Dilated cardiomyopathy 1 P23229,P05556,P08648,P17301 297 6.26e-08 18 4 3 0.750 0.167 REAC:3000170 rea 1 Syndecan interactions 1 P23229,P05556,P17301 297 1.06e-07 171 4 4 1.000 0.023 GO:0031589 BP 1 cell-substrate adhesion 1 P23229,P05556,P08648,P17301 297 1.36e-07 23 4 3 0.750 0.130 REAC:3000157 rea 1 Laminin interactions 1 P23229,P05556,P17301 297 1.59e-07 31 4 3 0.750 0.097 GO:0033627 BP 1 cell adhesion mediated by integrin 1 P05556,P08648,P17301 297 2.05e-07 2 4 2 0.500 1.000 GO:0034666 CC 1 integrin alpha2-beta1 complex 1 P05556,P17301 297 2.16e-07 204 4 4 1.000 0.020 GO:0030198 BP 1 extracellular matrix organization 1 P23229,P05556,P08648,P17301 297 2.16e-07 204 4 4 1.000 0.020 GO:0043062 BP 1 extracellular structure organization 1 P23229,P05556,P08648,P17301 297 6.15e-07 3 4 2 0.500 0.667 GO:0098634 MF 1 protein binding involved in cell-matrix adhesion 1 P05556,P17301 297 6.15e-07 3 4 2 0.500 0.667 GO:0098639 MF 1 collagen binding involved in cell-matrix adhesion 1 P05556,P17301 297 6.99e-07 39 4 3 0.750 0.077 REAC:3000171 rea 1 Non-integrin membrane-ECM interactions 1 P23229,P05556,P17301 297 8.30e-07 53 4 3 0.750 0.057 GO:0001704 BP 1 formation of primary germ layer 1 P05556,P08648,P17301 297 8.32e-07 3 4 2 0.500 0.667 REAC:1566977 rea 1 Fibronectin matrix formation 1 P05556,P08648 297 1.17e-06 228 4 4 1.000 0.018 REAC:1474244 rea 1 Extracellular matrix organization 1 P23229,P05556,P08648,P17301 297 1.18e-06 311 4 4 1.000 0.013 GO:0009986 CC 1 cell surface 1 P23229,P05556,P08648,P17301 297 1.55e-06 333 4 4 1.000 0.012 GO:0005924 CC 1 cell-substrate adherens junction 1 P23229,P05556,P08648,P17301 297 1.55e-06 333 4 4 1.000 0.012 GO:0005925 CC 1 focal adhesion 1 P23229,P05556,P08648,P17301 297 1.63e-06 337 4 4 1.000 0.012 GO:0030055 CC 1 cell-substrate junction 1 P23229,P05556,P08648,P17301 297 1.78e-06 175 4 4 1.000 0.023 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 P23229,P05556,P08648,P17301 297 1.84e-06 37 4 3 0.750 0.081 KEGG:04640 keg 1 Hematopoietic cell lineage 1 P23229,P08648,P17301 297 1.94e-06 179 4 4 1.000 0.022 KEGG:04510 keg 1 Focal adhesion 1 P23229,P05556,P08648,P17301 297 2.02e-06 71 4 3 0.750 0.042 GO:0007369 BP 1 gastrulation 1 P05556,P08648,P17301 297 2.69e-06 382 4 4 1.000 0.010 GO:0048646 BP 1 anatomical structure formation involved in morphogenesis 1 P23229,P05556,P08648,P17301 297 4.18e-06 70 4 3 0.750 0.043 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 P23229,P05556,P08648 297 5.37e-06 98 4 3 0.750 0.031 GO:0098802 CC 1 plasma membrane receptor complex 1 P05556,P08648,P17301 297 5.82e-06 7 4 2 0.500 0.286 REAC:75892 rea 1 Platelet Adhesion to exposed collagen 1 P05556,P17301 297 7.76e-06 8 4 2 0.500 0.250 REAC:447041 rea 1 CHL1 interactions 1 P05556,P17301 297 8.35e-06 257 4 4 1.000 0.016 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 P23229,P05556,P08648,P17301 297 9.88e-06 93 4 3 0.750 0.032 REAC:373760 rea 1 L1CAM interactions 1 P05556,P08648,P17301 297 1.12e-05 125 4 3 0.750 0.024 GO:0098797 CC 1 plasma membrane protein complex 1 P05556,P08648,P17301 297 1.31e-05 2 4 2 0.500 1.000 CORUM:2385 cor 1 ITGA5-ITGB4 complex 1 P05556,P08648 297 1.31e-05 2 4 2 0.500 1.000 CORUM:2432 cor 1 ITGA2-ITGB1 complex 1 P05556,P17301 297 1.31e-05 2 4 2 0.500 1.000 CORUM:2413 cor 1 ITGA6-ITGB1 complex 1 P23229,P05556 297 1.35e-05 12 4 2 0.500 0.167 GO:0048333 BP 1 mesodermal cell differentiation 1 P05556,P17301 297 1.46e-05 582 4 4 1.000 0.007 GO:0005912 CC 1 adherens junction 1 P23229,P05556,P08648,P17301 297 1.55e-05 591 4 4 1.000 0.007 GO:0070161 CC 1 anchoring junction 1 P23229,P05556,P08648,P17301 297 1.60e-05 13 4 2 0.500 0.154 GO:2000811 BP 1 negative regulation of anoikis 1 P05556,P08648 297 1.70e-05 444 4 4 1.000 0.009 REAC:109582 rea 1 Hemostasis 1 P23229,P05556,P08648,P17301 297 2.13e-05 640 4 4 1.000 0.006 GO:0016477 BP 1 cell migration 1 P23229,P05556,P08648,P17301 297 2.24e-05 84 4 3 0.750 0.036 KEGG:05222 keg 1 Small cell lung cancer 1 P23229,P05556,P17301 297 2.63e-05 166 4 3 0.750 0.018 GO:0050900 BP 1 leukocyte migration 1 P23229,P05556,P08648 297 2.69e-05 678 4 4 1.000 0.006 GO:0007155 BP 1 cell adhesion 1 P23229,P05556,P08648,P17301 297 2.79e-05 684 4 4 1.000 0.006 GO:0022610 BP 1 biological adhesion 1 P23229,P05556,P08648,P17301 297 3.08e-05 175 4 3 0.750 0.017 GO:0048598 BP 1 embryonic morphogenesis 1 P05556,P08648,P17301 297 3.13e-05 18 4 2 0.500 0.111 GO:2000209 BP 1 regulation of anoikis 1 P05556,P08648 297 3.25e-05 711 4 4 1.000 0.006 GO:0048870 BP 1 cell motility 1 P23229,P05556,P08648,P17301 297 3.25e-05 711 4 4 1.000 0.006 GO:0051674 BP 1 localization of cell 1 P23229,P05556,P08648,P17301 297 3.50e-05 19 4 2 0.500 0.105 GO:0001707 BP 1 mesoderm formation 1 P05556,P17301 297 3.88e-05 20 4 2 0.500 0.100 GO:0043276 BP 1 anoikis 1 P05556,P08648 297 3.88e-05 20 4 2 0.500 0.100 GO:0048332 BP 1 mesoderm morphogenesis 1 P05556,P17301 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2429 cor 1 ITGA2-ITGB1-CD47 complex 1 P05556,P17301 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2431 cor 1 ITGA2-ITGB1-COL6A3 complex 1 P05556,P17301 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2430 cor 1 ITGA2-ITGB1-CHAD complex 1 P05556,P17301 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2437 cor 1 ITGA6-ITGB1-CYR61 complex 1 P23229,P05556 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2853 cor 1 ITGA5-ITGB1-CAL4A3 complex 1 P05556,P08648 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2384 cor 1 ITGA5-ITGB1-ADAM15 complex 1 P05556,P08648 297 3.92e-05 3 4 2 0.500 0.667 CORUM:2411 cor 1 ITGA6-ITGB1-CD151 complex 1 P23229,P05556 297 3.92e-05 3 4 2 0.500 0.667 CORUM:3112 cor 1 ITGA5-ITGB1-SPP1 complex 1 P05556,P08648 297 3.94e-05 746 4 4 1.000 0.005 GO:0030054 CC 1 cell junction 1 P23229,P05556,P08648,P17301 297 4.05e-05 751 4 4 1.000 0.005 GO:0009888 BP 1 tissue development 1 P23229,P05556,P08648,P17301 297 4.34e-05 196 4 3 0.750 0.015 GO:0043235 CC 1 receptor complex 1 P05556,P08648,P17301 297 4.73e-05 19 4 2 0.500 0.105 REAC:210991 rea 1 Basigin interactions 1 P23229,P05556 297 5.59e-05 814 4 4 1.000 0.005 GO:0040011 BP 1 locomotion 1 P23229,P05556,P08648,P17301 297 5.81e-05 21 4 2 0.500 0.095 REAC:445144 rea 1 Signal transduction by L1 1 P05556,P08648 297 7.24e-05 124 4 3 0.750 0.024 KEGG:04145 keg 1 Phagosome 1 P05556,P08648,P17301 297 7.84e-05 4 4 2 0.500 0.500 CORUM:2383 cor 1 ITGA5-ITGB1-FN1-TGM2 complex 1 P05556,P08648 297 7.84e-05 4 4 2 0.500 0.500 CORUM:2850 cor 1 ITGA5-ITGB1-FN-1-NOV complex 1 P05556,P08648 297 9.69e-05 27 4 2 0.500 0.074 REAC:1566948 rea 1 Elastic fibre formation 1 P05556,P08648 297 1.01e-04 32 4 2 0.500 0.062 GO:0034113 BP 1 heterotypic cell-cell adhesion 1 P05556,P08648 297 1.12e-04 269 4 3 0.750 0.011 GO:0048729 BP 1 tissue morphogenesis 1 P05556,P08648,P17301 297 1.22e-04 277 4 3 0.750 0.011 GO:0098631 MF 1 protein binding involved in cell adhesion 1 P23229,P05556,P17301 297 1.28e-04 281 4 3 0.750 0.011 GO:0009790 BP 1 embryo development 1 P05556,P08648,P17301 297 1.29e-04 36 4 2 0.500 0.056 GO:0007498 BP 1 mesoderm development 1 P05556,P17301 297 1.36e-04 1016 4 4 1.000 0.004 GO:0006928 BP 1 movement of cell or subcellular component 1 P23229,P05556,P08648,P17301 297 1.43e-04 38 4 2 0.500 0.053 GO:0005518 MF 1 collagen binding 1 P05556,P17301 297 1.59e-04 40 4 2 0.500 0.050 GO:0032587 CC 1 ruffle membrane 1 P05556,P08648 297 1.92e-04 1107 4 4 1.000 0.004 GO:0009653 BP 1 anatomical structure morphogenesis 1 P23229,P05556,P08648,P17301 297 1.97e-04 173 4 3 0.750 0.017 KEGG:05205 keg 1 Proteoglycans in cancer 1 P05556,P08648,P17301 297 2.30e-04 48 4 2 0.500 0.042 GO:0007229 BP 1 integrin-mediated signaling pathway 1 P05556,P17301 297 2.49e-04 43 4 2 0.500 0.047 REAC:3000178 rea 1 ECM proteoglycans 1 P05556,P17301 297 3.02e-04 55 4 2 0.500 0.036 GO:0031256 CC 1 leading edge membrane 1 P05556,P08648 297 3.65e-04 52 4 2 0.500 0.038 REAC:446728 rea 1 Cell junction organization 1 P23229,P05556 297 3.89e-04 408 4 3 0.750 0.007 GO:0043066 BP 1 negative regulation of apoptotic process 1 P23229,P05556,P08648 297 4.12e-04 416 4 3 0.750 0.007 GO:0043069 BP 1 negative regulation of programmed cell death 1 P23229,P05556,P08648 297 4.24e-04 420 4 3 0.750 0.007 GO:0005911 CC 1 cell-cell junction 1 P23229,P05556,P08648 297 5.00e-04 444 4 3 0.750 0.007 GO:0098796 CC 1 membrane protein complex 1 P05556,P08648,P17301 297 5.14e-04 448 4 3 0.750 0.007 GO:0060548 BP 1 negative regulation of cell death 1 P23229,P05556,P08648 297 5.14e-04 1416 4 4 1.000 0.003 GO:0007166 BP 1 cell surface receptor signaling pathway 1 P23229,P05556,P08648,P17301 297 6.90e-04 1524 4 4 1.000 0.003 GO:0030154 BP 1 cell differentiation 1 P23229,P05556,P08648,P17301 297 7.07e-04 84 4 2 0.500 0.024 GO:0001726 CC 1 ruffle 1 P05556,P08648 297 7.88e-04 1 4 1 0.250 1.000 GO:0034681 CC 1 integrin alpha11-beta1 complex 1 P05556 297 7.88e-04 1 4 1 0.250 1.000 GO:0034680 CC 1 integrin alpha10-beta1 complex 1 P05556 297 8.18e-04 53 4 2 0.500 0.038 KEGG:05133 keg 1 Pertussis 1 P05556,P08648 297 9.46e-04 1649 4 4 1.000 0.002 GO:0048869 BP 1 cellular developmental process 1 P23229,P05556,P08648,P17301 297 1.12e-03 62 4 2 0.500 0.032 KEGG:05131 keg 1 Shigellosis 1 P05556,P08648 297 1.15e-03 107 4 2 0.500 0.019 GO:0031253 CC 1 cell projection membrane 1 P05556,P08648 297 1.17e-03 459 4 3 0.750 0.007 REAC:422475 rea 1 Axon guidance 1 P05556,P08648,P17301 297 1.19e-03 94 4 2 0.500 0.021 REAC:1500931 rea 1 Cell-Cell communication 1 P23229,P05556 297 1.24e-03 111 4 2 0.500 0.018 GO:0043547 BP 1 positive regulation of GTPase activity 1 P23229,P05556 297 1.28e-03 113 4 2 0.500 0.018 GO:0007160 BP 1 cell-matrix adhesion 1 P05556,P17301 297 1.28e-03 325 4 3 0.750 0.009 KEGG:05200 keg 1 Pathways in cancer 1 P23229,P05556,P17301 297 1.37e-03 1810 4 4 1.000 0.002 GO:0048731 BP 1 system development 1 P23229,P05556,P08648,P17301 297 1.55e-03 73 4 2 0.500 0.027 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 P05556,P08648 297 1.58e-03 2 4 1 0.250 0.500 GO:0035878 BP 1 nail development 1 P23229 297 1.58e-03 2 4 1 0.250 0.500 GO:0007161 BP 1 calcium-independent cell-matrix adhesion 1 P05556 297 1.58e-03 2 4 1 0.250 0.500 GO:0034667 CC 1 integrin alpha3-beta1 complex 1 P05556 297 1.58e-03 2 4 1 0.250 0.500 GO:0034665 CC 1 integrin alpha1-beta1 complex 1 P05556 297 1.58e-03 2 4 1 0.250 0.500 GO:0034678 CC 1 integrin alpha8-beta1 complex 1 P05556 297 1.58e-03 2 4 1 0.250 0.500 GO:0010668 BP 1 ectodermal cell differentiation 1 P23229 297 1.58e-03 2 4 1 0.250 0.500 GO:0071062 CC 1 alphav-beta3 integrin-vitronectin complex 1 P08648 297 1.59e-03 74 4 2 0.500 0.027 KEGG:04514 keg 1 Cell adhesion molecules (CAMs) 1 P23229,P05556 297 2.00e-03 3 4 1 0.250 0.333 REAC:446343 rea 1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1 P05556 297 2.08e-03 2007 4 4 1.000 0.002 GO:0007275 BP 1 multicellular organism development 1 P23229,P05556,P08648,P17301 297 2.28e-03 151 4 2 0.500 0.013 GO:0043087 BP 1 regulation of GTPase activity 1 P23229,P05556 297 2.33e-03 746 4 3 0.750 0.004 GO:0042981 BP 1 regulation of apoptotic process 1 P23229,P05556,P08648 297 2.36e-03 3 4 1 0.250 0.333 GO:0038065 BP 1 collagen-activated signaling pathway 1 P17301 297 2.36e-03 3 4 1 0.250 0.333 GO:0038064 MF 1 collagen receptor activity 1 P17301 297 2.36e-03 3 4 1 0.250 0.333 GO:0010710 BP 1 regulation of collagen catabolic process 1 P05556 297 2.42e-03 756 4 3 0.750 0.004 GO:0043067 BP 1 regulation of programmed cell death 1 P23229,P05556,P08648 297 2.62e-03 95 4 2 0.500 0.021 KEGG:05145 keg 1 Toxoplasmosis 1 P23229,P05556 297 2.95e-03 808 4 3 0.750 0.004 GO:0005887 CC 1 integral component of plasma membrane 1 P05556,P08648,P17301 297 2.98e-03 811 4 3 0.750 0.004 GO:0010941 BP 1 regulation of cell death 1 P23229,P05556,P08648 297 3.08e-03 103 4 2 0.500 0.019 KEGG:04611 keg 1 Platelet activation 1 P05556,P17301 297 3.09e-03 176 4 2 0.500 0.011 GO:0031252 CC 1 cell leading edge 1 P05556,P08648 297 3.15e-03 4 4 1 0.250 0.250 GO:0043184 MF 1 vascular endothelial growth factor receptor 2 binding 1 P08648 297 3.15e-03 4 4 1 0.250 0.250 GO:0071438 CC 1 invadopodium membrane 1 P05556 297 3.15e-03 4 4 1 0.250 0.250 GO:0019960 MF 1 C-X3-C chemokine binding 1 P05556 297 3.34e-03 843 4 3 0.750 0.004 GO:0031226 CC 1 intrinsic component of plasma membrane 1 P05556,P08648,P17301 297 3.60e-03 1 4 1 0.250 1.000 OMIM:614200 omi 1 BLEEDING DISORDER, PLATELET-TYPE, 9; BDPLT9;;GLYCOPROTEIN Ia DEFICIENCY;;GP Ia DEFICIENCY;;COLLAGEN PLATELET RECEPTOR DEFICIENCY 1 P17301 297 3.93e-03 2353 4 4 1.000 0.002 GO:0048856 BP 1 anatomical structure development 1 P23229,P05556,P08648,P17301 297 3.94e-03 5 4 1 0.250 0.200 GO:0038132 MF 1 neuregulin binding 1 P23229 297 3.94e-03 5 4 1 0.250 0.200 GO:0005172 MF 1 vascular endothelial growth factor receptor binding 1 P08648 297 3.94e-03 5 4 1 0.250 0.200 GO:0071402 BP 1 cellular response to lipoprotein particle stimulus 1 P05556 297 3.94e-03 5 4 1 0.250 0.200 GO:0071404 BP 1 cellular response to low-density lipoprotein particle stimulus 1 P05556 297 4.37e-03 718 4 3 0.750 0.004 REAC:1266738 rea 1 Developmental Biology 1 P05556,P08648,P17301 297 4.39e-03 2420 4 4 1.000 0.002 GO:0005886 CC 1 plasma membrane 1 P23229,P05556,P08648,P17301 297 4.55e-03 936 4 3 0.750 0.003 GO:0006915 BP 1 apoptotic process 1 P23229,P05556,P08648 297 4.76e-03 2469 4 4 1.000 0.002 GO:0071944 CC 1 cell periphery 1 P23229,P05556,P08648,P17301 297 4.84e-03 956 4 3 0.750 0.003 GO:0012501 BP 1 programmed cell death 1 P23229,P05556,P08648 297 4.88e-03 2485 4 4 1.000 0.002 GO:0044767 BP 1 single-organism developmental process 1 P23229,P05556,P08648,P17301 297 5.51e-03 7 4 1 0.250 0.143 GO:0031994 MF 1 insulin-like growth factor I binding 1 P23229 297 5.51e-03 7 4 1 0.250 0.143 GO:0071437 CC 1 invadopodium 1 P05556 297 5.51e-03 7 4 1 0.250 0.143 GO:0055098 BP 1 response to low-density lipoprotein particle 1 P05556 297 5.51e-03 7 4 1 0.250 0.143 GO:0097186 BP 1 amelogenesis 1 P23229 297 5.51e-03 7 4 1 0.250 0.143 GO:0033631 BP 1 cell-cell adhesion mediated by integrin 1 P05556 297 5.67e-03 2580 4 4 1.000 0.002 GO:0032502 BP 1 developmental process 1 P23229,P05556,P08648,P17301 297 6.00e-03 1029 4 3 0.750 0.003 GO:0008219 BP 1 cell death 1 P23229,P05556,P08648 297 6.00e-03 9 4 1 0.250 0.111 REAC:446107 rea 1 Type I hemidesmosome assembly 1 P23229 297 6.30e-03 8 4 1 0.250 0.125 GO:0007398 BP 1 ectoderm development 1 P23229 297 6.30e-03 8 4 1 0.250 0.125 GO:0055094 BP 1 response to lipoprotein particle 1 P05556 297 6.30e-03 8 4 1 0.250 0.125 GO:0005520 MF 1 insulin-like growth factor binding 1 P23229 297 6.87e-03 2706 4 4 1.000 0.001 GO:0044707 BP 1 single-multicellular organism process 1 P23229,P05556,P08648,P17301 297 7.08e-03 9 4 1 0.250 0.111 GO:0050901 BP 1 leukocyte tethering or rolling 1 P05556 297 7.08e-03 9 4 1 0.250 0.111 GO:0030949 BP 1 positive regulation of vascular endothelial growth factor receptor signaling pathway 1 P08648 297 7.08e-03 9 4 1 0.250 0.111 GO:0035313 BP 1 wound healing, spreading of epidermal cells 1 P08648 297 7.08e-03 9 4 1 0.250 0.111 GO:1903672 BP 1 positive regulation of sprouting angiogenesis 1 P08648 297 7.19e-03 2 4 1 0.250 0.500 OMIM:226730 omi 1 EPIDERMOLYSIS BULLOSA JUNCTIONALIS WITH PYLORIC ATRESIA;;EPIDERMOLYSIS BULLOSA, JUNCTIONAL, WITH PYLORIC ATRESIA;;JUNCTIONAL EPIDERMOLYSIS BULLOSA WITH PYLORIC ATRESIA;;JEB-PA;;EPIDERMOLYSIS BULLOSA, JUNCTIONAL, WITH PYLORIC ATRESIA AND APLASIACUTIS CONGENITA;;EB-PA-ACC;;CARMI SYNDROME;;APLASIA CUTIS CONGENITA WITH GASTROINTESTINAL ATRESIA 1 P23229 297 7.26e-03 271 4 2 0.500 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 P23229,P05556 297 7.48e-03 275 4 2 0.500 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 P23229,P05556 297 7.55e-03 1113 4 3 0.750 0.003 GO:0048513 BP 1 animal organ development 1 P23229,P05556,P17301 297 7.86e-03 282 4 2 0.500 0.007 GO:0045296 MF 1 cadherin binding 1 P23229,P05556 297 7.87e-03 10 4 1 0.250 0.100 GO:0031581 BP 1 hemidesmosome assembly 1 P23229 297 7.87e-03 10 4 1 0.250 0.100 GO:0019956 MF 1 chemokine binding 1 P05556 297 7.87e-03 10 4 1 0.250 0.100 GO:0061756 BP 1 leukocyte adhesion to vascular endothelial cell 1 P05556 297 8.00e-03 12 4 1 0.250 0.083 REAC:416700 rea 1 Other semaphorin interactions 1 P05556 297 8.42e-03 292 4 2 0.500 0.007 GO:0051345 BP 1 positive regulation of hydrolase activity 1 P23229,P05556 297 8.53e-03 294 4 2 0.500 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 P23229,P05556 297 8.63e-03 1165 4 3 0.750 0.003 GO:0002376 BP 1 immune system process 1 P23229,P05556,P08648 297 8.65e-03 11 4 1 0.250 0.091 GO:0005161 MF 1 platelet-derived growth factor receptor binding 1 P08648 297 8.88e-03 300 4 2 0.500 0.007 GO:0042060 BP 1 wound healing 1 P08648,P17301 297 9.23e-03 306 4 2 0.500 0.007 GO:0043065 BP 1 positive regulation of apoptotic process 1 P23229,P05556 297 9.44e-03 12 4 1 0.250 0.083 GO:0010712 BP 1 regulation of collagen metabolic process 1 P05556 297 9.44e-03 12 4 1 0.250 0.083 GO:0044246 BP 1 regulation of multicellular organismal metabolic process 1 P05556 297 9.44e-03 12 4 1 0.250 0.083 GO:0001968 MF 1 fibronectin binding 1 P05556 297 9.53e-03 311 4 2 0.500 0.006 GO:0043068 BP 1 positive regulation of programmed cell death 1 P23229,P05556 297 9.83e-03 316 4 2 0.500 0.006 GO:0071363 BP 1 cellular response to growth factor stimulus 1 P05556,P08648 297 9.99e-03 15 4 1 0.250 0.067 REAC:446353 rea 1 Cell-extracellular matrix interactions 1 P05556 297 1.00e-02 1 4 1 0.250 1.000 CORUM:3057 cor 1 ITGA10-ITGB1 complex 1 P05556 297 1.00e-02 1 4 1 0.250 1.000 CORUM:3058 cor 1 ITGA11-ITGB1 complex 1 P05556 297 1.00e-02 1 4 1 0.250 1.000 CORUM:3035 cor 1 LAT2-ITGB1 complex 1 P05556 297 1.01e-02 320 4 2 0.500 0.006 GO:0098590 CC 1 plasma membrane region 1 P05556,P08648 297 1.02e-02 13 4 1 0.250 0.077 GO:0030947 BP 1 regulation of vascular endothelial growth factor receptor signaling pathway 1 P08648 297 1.04e-02 325 4 2 0.500 0.006 GO:0010942 BP 1 positive regulation of cell death 1 P23229,P05556 297 1.04e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 P23229,P05556,P08648,P17301 297 1.05e-02 326 4 2 0.500 0.006 GO:0070848 BP 1 response to growth factor 1 P05556,P08648 297 1.10e-02 334 4 2 0.500 0.006 GO:0016337 BP 1 single organismal cell-cell adhesion 1 P05556,P08648 297 1.10e-02 334 4 2 0.500 0.006 GO:0009611 BP 1 response to wounding 1 P08648,P17301 297 1.10e-02 14 4 1 0.250 0.071 GO:0006929 BP 1 substrate-dependent cell migration 1 P17301 297 1.12e-02 1272 4 3 0.750 0.002 GO:0044459 CC 1 plasma membrane part 1 P05556,P08648,P17301 297 1.14e-02 3073 4 4 1.000 0.001 GO:0032501 BP 1 multicellular organismal process 1 P23229,P05556,P08648,P17301 297 1.18e-02 15 4 1 0.250 0.067 GO:0042475 BP 1 odontogenesis of dentin-containing tooth 1 P23229 297 1.19e-02 348 4 2 0.500 0.006 GO:0009887 BP 1 animal organ morphogenesis 1 P23229,P17301 297 1.20e-02 18 4 1 0.250 0.056 REAC:2129379 rea 1 Molecules associated with elastic fibres 1 P05556 297 1.33e-02 369 4 2 0.500 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 P23229,P05556 297 1.34e-02 370 4 2 0.500 0.005 GO:0098602 BP 1 single organism cell adhesion 1 P05556,P08648 297 1.44e-02 3741 4 4 1.000 0.001 HPA:039020 hpa 1 soft tissue 1; chondrocytes 1 P23229,P05556,P08648,P17301 297 1.44e-02 384 4 2 0.500 0.005 GO:0032403 MF 1 protein complex binding 1 P05556,P17301 297 1.45e-02 1392 4 3 0.750 0.002 GO:0016021 CC 1 integral component of membrane 1 P05556,P08648,P17301 297 1.45e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 P23229,P05556,P08648,P17301 297 1.46e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 P23229,P05556,P08648,P17301 297 1.47e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 P23229,P05556,P08648,P17301 297 1.48e-02 389 4 2 0.500 0.005 GO:0098609 BP 1 cell-cell adhesion 1 P05556,P08648 297 1.49e-02 19 4 1 0.250 0.053 GO:0044319 BP 1 wound healing, spreading of cells 1 P08648 297 1.49e-02 19 4 1 0.250 0.053 GO:0090505 BP 1 epiboly involved in wound healing 1 P08648 297 1.49e-02 19 4 1 0.250 0.053 GO:0006968 BP 1 cellular defense response 1 P05556 297 1.49e-02 19 4 1 0.250 0.053 GO:1903670 BP 1 regulation of sprouting angiogenesis 1 P08648 297 1.49e-02 19 4 1 0.250 0.053 GO:0015026 MF 1 coreceptor activity 1 P05556 297 1.57e-02 20 4 1 0.250 0.050 GO:0031594 CC 1 neuromuscular junction 1 P05556 297 1.57e-02 20 4 1 0.250 0.050 GO:0090504 BP 1 epiboly 1 P08648 297 1.60e-02 1440 4 3 0.750 0.002 GO:0031224 CC 1 intrinsic component of membrane 1 P05556,P08648,P17301 297 1.63e-02 409 4 2 0.500 0.005 GO:0044463 CC 1 cell projection part 1 P05556,P08648 297 1.65e-02 21 4 1 0.250 0.048 GO:0045123 BP 1 cellular extravasation 1 P05556 297 1.67e-02 2 4 1 0.250 0.500 HP:0004399 hp 1 Congenital pyloric atresia 1 P23229 297 1.71e-02 3401 4 4 1.000 0.001 GO:0051179 BP 1 localization 1 P23229,P05556,P08648,P17301 297 1.81e-02 23 4 1 0.250 0.043 GO:0090004 BP 1 positive regulation of establishment of protein localization to plasma membrane 1 P05556 297 1.96e-02 25 4 1 0.250 0.040 GO:1904377 BP 1 positive regulation of protein localization to cell periphery 1 P05556 297 1.96e-02 25 4 1 0.250 0.040 GO:1903078 BP 1 positive regulation of protein localization to plasma membrane 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2436 cor 1 ITGAV-ITGB1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:3104 cor 1 ITGB1-NRP1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2406 cor 1 ITGA3-ITGB1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2419 cor 1 ITGA4-ITGB1-CD81 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2323 cor 1 ITGA6-ITGB4 complex 1 P23229 297 2.00e-02 2 4 1 0.250 0.500 CORUM:3059 cor 1 ITGA11-ITGB1-COL1A1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2439 cor 1 ITGA8-ITGB1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2417 cor 1 ITGA4-ITGB1-EMILIN1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2444 cor 1 ITGB1-ITGA9 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2428 cor 1 ITGA4-ITGB1-THBS2 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2397 cor 1 ITGA7-ITGB1-ITGB1BP3 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2418 cor 1 ITGA4-ITGB1 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2420 cor 1 ITGA4-ITGB1-CD53 complex 1 P05556 297 2.00e-02 2 4 1 0.250 0.500 CORUM:2971 cor 1 ITGA9-ITGB1-VEGFC complex 1 P05556 297 2.26e-02 484 4 2 0.500 0.004 GO:0042327 BP 1 positive regulation of phosphorylation 1 P23229,P08648 297 2.28e-02 29 4 1 0.250 0.034 GO:0042476 BP 1 odontogenesis 1 P23229 297 2.35e-02 30 4 1 0.250 0.033 GO:0002011 BP 1 morphogenesis of an epithelial sheet 1 P08648 297 2.36e-02 495 4 2 0.500 0.004 GO:0038023 MF 1 signaling receptor activity 1 P05556,P17301 297 2.42e-02 2072 4 3 0.750 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 P23229,P08648,P17301 297 2.47e-02 506 4 2 0.500 0.004 GO:0051336 BP 1 regulation of hydrolase activity 1 P23229,P05556 297 2.50e-02 3 4 1 0.250 0.333 HP:0005984 hp 1 Elevated maternal serum alpha-fetoprotein 1 P23229 297 2.51e-02 32 4 1 0.250 0.031 GO:0035987 BP 1 endodermal cell differentiation 1 P08648 297 2.55e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 P23229,P05556,P08648,P17301 297 2.59e-02 33 4 1 0.250 0.030 GO:0055123 BP 1 digestive system development 1 P23229 297 2.59e-02 33 4 1 0.250 0.030 GO:0048565 BP 1 digestive tract development 1 P23229 297 2.67e-02 34 4 1 0.250 0.029 GO:0007156 BP 1 homophilic cell adhesion via plasma membrane adhesion molecules 1 P05556 297 2.69e-02 529 4 2 0.500 0.004 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 P23229,P08648 297 2.69e-02 529 4 2 0.500 0.004 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 P23229,P08648 297 2.74e-02 35 4 1 0.250 0.029 GO:0090003 BP 1 regulation of establishment of protein localization to plasma membrane 1 P05556 297 2.74e-02 35 4 1 0.250 0.029 GO:0001706 BP 1 endoderm formation 1 P08648 297 2.78e-02 2177 4 3 0.750 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P23229,P05556,P17301 297 2.91e-02 3882 4 4 1.000 0.001 GO:0016043 BP 1 cellular component organization 1 P23229,P05556,P08648,P17301 297 2.98e-02 38 4 1 0.250 0.026 GO:0042383 CC 1 sarcolemma 1 P05556 297 2.98e-02 38 4 1 0.250 0.026 GO:0007492 BP 1 endoderm development 1 P08648 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2395 cor 1 ITGA7-ITGB1-CD151 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2423 cor 1 ITGA4-ITGB1-CD47 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2390 cor 1 CD98-LAT2-ITGB1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2401 cor 1 ITGA3-ITGB1-THBS1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2321 cor 1 ITGA6-ITGB4-FYN complex 1 P23229 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2398 cor 1 ITGA3-ITGB1-BSG complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2770 cor 1 ITGA6-ITGB4-CD9 complex 1 P23229 297 3.00e-02 3 4 1 0.250 0.333 CORUM:3111 cor 1 ITGA9-ITGB1-SPP1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2445 cor 1 ITGA9-ITGB1-ADAM15 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2443 cor 1 ITGA9-ITGB1-TNC complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2422 cor 1 ITGA4-ITGB1-JAM2 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2320 cor 1 ITGA6-ITGB4-CD151 complex 1 P23229 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2396 cor 1 ITGA7-ITGB1-CD9 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2435 cor 1 ITGA1-ITGB1-PTPN2 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2446 cor 1 ITGA9-ITGB1-FIGF complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2442 cor 1 ITGA9-ITGB1-VCAM1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2885 cor 1 ITGAV-ITGB1-SPP1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2399 cor 1 ITGA3-ITGB1-CD63 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2882 cor 1 ITGA5-ITGB3-COL6A3 complex 1 P08648 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2400 cor 1 ITGA3-ITGB1-CD151 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2421 cor 1 ITGA4-ITGB1-VCAM1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2989 cor 1 ITGA9-ITGB1-ADAM8 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2972 cor 1 ITGA9-ITGB1-VEGFA complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2322 cor 1 ITGA6-ITGB4-LAMA5 complex 1 P23229 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2424 cor 1 ITGA4-ITGB1-CD63 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2416 cor 1 ITGB1-RAP1A-PKD1 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2447 cor 1 ITGA9-ITGB1-ADAM12 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2434 cor 1 ITGA1-ITGB1-COL6A3 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2440 cor 1 ITGA9-ITGB1-ADAM9 complex 1 P05556 297 3.00e-02 3 4 1 0.250 0.333 CORUM:2426 cor 1 ITGA4-ITGB1-THBS1 complex 1 P05556 297 3.13e-02 40 4 1 0.250 0.025 GO:0060173 BP 1 limb development 1 P23229 297 3.13e-02 40 4 1 0.250 0.025 GO:0048736 BP 1 appendage development 1 P23229 297 3.18e-02 48 4 1 0.250 0.021 REAC:2022090 rea 1 Assembly of collagen fibrils and other multimeric structures 1 P23229 297 3.24e-02 49 4 1 0.250 0.020 REAC:198933 rea 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1 P05556 297 3.32e-02 4013 4 4 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 P23229,P05556,P08648,P17301 297 3.36e-02 593 4 2 0.500 0.003 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 P05556,P08648 297 3.52e-02 45 4 1 0.250 0.022 GO:0030175 CC 1 filopodium 1 P05556 297 3.53e-02 609 4 2 0.500 0.003 GO:0060089 MF 1 molecular transducer activity 1 P05556,P17301 297 3.53e-02 609 4 2 0.500 0.003 GO:0004872 MF 1 receptor activity 1 P05556,P17301 297 3.60e-02 46 4 1 0.250 0.022 GO:0002040 BP 1 sprouting angiogenesis 1 P08648 297 3.73e-02 902 4 2 0.500 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P23229,P17301 297 3.76e-02 48 4 1 0.250 0.021 GO:0030038 BP 1 contractile actin filament bundle assembly 1 P05556 297 3.76e-02 48 4 1 0.250 0.021 GO:1903076 BP 1 regulation of protein localization to plasma membrane 1 P05556 297 3.76e-02 48 4 1 0.250 0.021 GO:0030183 BP 1 B cell differentiation 1 P05556 297 3.76e-02 48 4 1 0.250 0.021 GO:0043149 BP 1 stress fiber assembly 1 P05556 297 3.76e-02 48 4 1 0.250 0.021 GO:0019955 MF 1 cytokine binding 1 P05556 297 3.84e-02 49 4 1 0.250 0.020 GO:1904375 BP 1 regulation of protein localization to cell periphery 1 P05556 297 3.90e-02 59 4 1 0.250 0.017 REAC:373755 rea 1 Semaphorin interactions 1 P05556 297 3.91e-02 50 4 1 0.250 0.020 GO:0031623 BP 1 receptor internalization 1 P05556 297 3.99e-02 51 4 1 0.250 0.020 GO:0030574 BP 1 collagen catabolic process 1 P05556 297 4.00e-02 4 4 1 0.250 0.250 CORUM:3096 cor 1 ITGA6-ITGB4-SHC1-GRB2 complex 1 P23229 297 4.06e-02 943 4 2 0.500 0.002 HPA:035040_03 hpa 1 skin 1; melanocytes[Uncertain,High] 1 P05556,P17301 297 4.07e-02 52 4 1 0.250 0.019 GO:0045766 BP 1 positive regulation of angiogenesis 1 P08648 297 4.08e-02 945 4 2 0.500 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P05556,P17301 297 4.15e-02 53 4 1 0.250 0.019 GO:1903729 BP 1 regulation of plasma membrane organization 1 P05556 297 4.16e-02 4876 4 4 1.000 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 P23229,P05556,P08648,P17301 297 4.17e-02 5 4 1 0.250 0.200 HP:0001060 hp 1 Axillary pterygia 1 P23229 297 4.17e-02 5 4 1 0.250 0.200 HP:0003341 hp 1 Junctional split 1 P23229 297 4.22e-02 54 4 1 0.250 0.019 GO:0044243 BP 1 multicellular organism catabolic process 1 P05556 297 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P23229,P08648 297 4.26e-02 671 4 2 0.500 0.003 GO:0043085 BP 1 positive regulation of catalytic activity 1 P23229,P05556 297 4.30e-02 55 4 1 0.250 0.018 GO:0070851 MF 1 growth factor receptor binding 1 P08648 297 4.45e-02 2574 4 3 0.750 0.001 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 P23229,P08648,P17301 297 4.46e-02 57 4 1 0.250 0.018 GO:0007044 BP 1 cell-substrate junction assembly 1 P23229 297 4.49e-02 690 4 2 0.500 0.003 GO:0044877 MF 1 macromolecular complex binding 1 P05556,P17301 297 4.50e-02 2585 4 3 0.750 0.001 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 P23229,P05556,P08648 297 4.55e-02 2071 4 3 0.750 0.001 GO:0006950 BP 1 response to stress 1 P05556,P08648,P17301 297 4.62e-02 4356 4 4 1.000 0.001 GO:0050896 BP 1 response to stimulus 1 P23229,P05556,P08648,P17301 297 4.69e-02 60 4 1 0.250 0.017 GO:2001237 BP 1 negative regulation of extrinsic apoptotic signaling pathway 1 P23229 297 4.70e-02 2096 4 3 0.750 0.001 GO:0043234 CC 1 protein complex 1 P05556,P08648,P17301 297 4.74e-02 2101 4 3 0.750 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 P23229,P05556,P08648 297 4.77e-02 61 4 1 0.250 0.016 GO:1904018 BP 1 positive regulation of vasculature development 1 P08648 297 4.89e-02 721 4 2 0.500 0.003 GO:0004871 MF 1 signal transducer activity 1 P05556,P17301 297 4.90e-02 49 4 1 0.250 0.020 KEGG:05140 keg 1 Leishmaniasis 1 P05556 297 4.98e-02 728 4 2 0.500 0.003 GO:0042995 CC 1 cell projection 1 P05556,P08648 297 5.00e-02 5 4 1 0.250 0.200 CORUM:2319 cor 1 ITGA6-ITGB4-Laminin10/12 complex 1 P23229 297 5.00e-02 50 4 1 0.250 0.020 KEGG:05130 keg 1 Pathogenic Escherichia coli infection 1 P05556 297 5.00e-02 76 4 1 0.250 0.013 REAC:1474290 rea 1 Collagen formation 1 P23229 297 5.00e-02 111 4 2 0.500 0.018 TF:M04197_0 tf 1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 0 1 P08648,P17301 297 5.00e-02 5 4 1 0.250 0.200 CORUM:2318 cor 1 ITGA6-ITGB4-Laminin10/12 complex 1 P23229 297 5.00e-02 6 4 1 0.250 0.167 HP:0002041 hp 1 Intractable diarrhea 1 P23229 297 5.00e-02 14 4 1 0.250 0.071 OMIM:231200 omi 1 Platelet-Type Bleeding Disorders 1 P17301 298 1.74e-03 468 2 2 1.000 0.004 MI:hsa-miR-339-3p mi 1 MI:hsa-miR-339-3p 1 Q8NA92,Q9BUW7 298 1.94e-03 561 2 2 1.000 0.004 TF:M03856_0 tf 1 Factor: Tbx5; motif: YMTYCTCWCACYTGN; match class: 0 1 Q8NA92,Q9BUW7 298 5.04e-03 904 2 2 1.000 0.002 TF:M01273_1 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 1 Q8NA92,Q9BUW7 298 6.80e-03 1050 2 2 1.000 0.002 TF:M02004_1 tf 1 Factor: GATA-1; motif: NNNNNWGATARNNNN; match class: 1 1 Q8NA92,Q9BUW7 298 6.90e-03 44 2 1 0.500 0.023 TF:M06635_0 tf 1 Factor: znf607; motif: NCCTTGAAGGGM; match class: 0 1 Q9BUW7 298 8.94e-03 57 2 1 0.500 0.018 TF:M06605_0 tf 1 Factor: ZNF681; motif: SGGGGTAAAGM; match class: 0 1 Q9BUW7 298 9.65e-03 1251 2 2 1.000 0.002 TF:M07343_0 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 0 1 Q8NA92,Q9BUW7 298 1.51e-02 1565 2 2 1.000 0.001 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 Q8NA92,Q9BUW7 298 1.70e-02 1659 2 2 1.000 0.001 TF:M01013_0 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 0 1 Q8NA92,Q9BUW7 298 1.77e-02 1694 2 2 1.000 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 Q8NA92,Q9BUW7 298 1.78e-02 114 2 1 0.500 0.009 TF:M04218_1 tf 1 Factor: MAFK; motif: NTGCTGANTCAGCRN; match class: 1 1 Q9BUW7 298 1.80e-02 1708 2 2 1.000 0.001 TF:M00203_0 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 0 1 Q8NA92,Q9BUW7 298 1.95e-02 1776 2 2 1.000 0.001 TF:M01843_1 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 1 1 Q8NA92,Q9BUW7 298 1.96e-02 1784 2 2 1.000 0.001 TF:M07409_1 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 1 Q8NA92,Q9BUW7 298 1.97e-02 126 2 1 0.500 0.008 TF:M06518_0 tf 1 Factor: znf383; motif: NAMTCCTGGARM; match class: 0 1 Q9BUW7 298 2.17e-02 139 2 1 0.500 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q9BUW7 298 2.30e-02 147 2 1 0.500 0.007 TF:M00203_1 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 1 1 Q8NA92 298 2.35e-02 1951 2 2 1.000 0.001 TF:M00926_0 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 0 1 Q8NA92,Q9BUW7 298 2.35e-02 1951 2 2 1.000 0.001 TF:M01267_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 Q8NA92,Q9BUW7 298 2.37e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q8NA92 298 2.37e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q8NA92 298 2.37e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q8NA92 298 2.37e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q8NA92 298 2.53e-02 162 2 1 0.500 0.006 TF:M04018_0 tf 1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 0 1 Q9BUW7 298 2.95e-02 189 2 1 0.500 0.005 TF:M00053_1 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 1 1 Q9BUW7 298 3.15e-02 202 2 1 0.500 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 Q9BUW7 298 3.28e-02 2305 2 2 1.000 0.001 TF:M00289_1 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 1 Q8NA92,Q9BUW7 298 3.45e-02 2365 2 2 1.000 0.001 TF:M00925_0 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 0 1 Q8NA92,Q9BUW7 298 3.58e-02 230 2 1 0.500 0.004 TF:M04364_0 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 0 1 Q8NA92 298 3.66e-02 2144 2 2 1.000 0.001 MI:rno-miR-000 mi 1 rno miRBase microRNAs 1 Q8NA92,Q9BUW7 298 3.87e-02 219 2 1 0.500 0.005 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 Q8NA92 298 4.07e-02 262 2 1 0.500 0.004 TF:M06887_1 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 1 1 Q8NA92 298 4.14e-02 266 2 1 0.500 0.004 TF:M04196_0 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 0 1 Q8NA92 298 4.14e-02 266 2 1 0.500 0.004 TF:M04196_1 tf 1 Factor: USF1; motif: RNCACGTGAY; match class: 1 1 Q8NA92 298 4.17e-02 268 2 1 0.500 0.004 TF:M04362_0 tf 1 Factor: HOXD12; motif: RGTCGTAAAAN; match class: 0 1 Q8NA92 298 4.19e-02 2605 2 2 1.000 0.001 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 Q8NA92,Q9BUW7 298 4.26e-02 274 2 1 0.500 0.004 TF:M04313_1 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 1 1 Q9BUW7 298 4.37e-02 281 2 1 0.500 0.004 TF:M03855_0 tf 1 Factor: Tbx5:csx; motif: YMTYCTSWCACYTGN; match class: 0 1 Q8NA92 298 4.41e-02 2674 2 2 1.000 0.001 TF:M07308_0 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 0 1 Q8NA92,Q9BUW7 298 4.49e-02 289 2 1 0.500 0.003 TF:M05950_0 tf 1 Factor: ZNF700; motif: NSGWGTARTTCS; match class: 0 1 Q8NA92 298 4.52e-02 291 2 1 0.500 0.003 TF:M04358_0 tf 1 Factor: HOXC13; motif: NCTCGTAAAAN; match class: 0 1 Q8NA92 298 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q8NA92,Q9BUW7 298 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q8NA92 298 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q8NA92 298 4.95e-02 2831 2 2 1.000 0.001 TF:M01273_0 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 0 1 Q8NA92,Q9BUW7 298 4.98e-02 321 2 1 0.500 0.003 TF:M04342_0 tf 1 Factor: HOXA13; motif: NCTCGTAAAAN; match class: 0 1 Q8NA92 298 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 Q9BUW7 299 2.09e-03 1 2 1 0.500 1.000 GO:0006014 BP 1 D-ribose metabolic process 1 Q9UKK9 299 2.09e-03 1 2 1 0.500 1.000 GO:0019303 BP 1 D-ribose catabolic process 1 Q9UKK9 299 3.39e-03 6 2 1 0.500 0.167 REAC:2393930 rea 1 Phosphate bond hydrolysis by NUDT proteins 1 Q9UKK9 299 4.17e-03 2 2 1 0.500 0.500 GO:0047631 MF 1 ADP-ribose diphosphatase activity 1 Q9UKK9 299 4.17e-03 2 2 1 0.500 0.500 GO:0019144 MF 1 ADP-sugar diphosphatase activity 1 Q9UKK9 299 4.17e-03 2 2 1 0.500 0.500 GO:0044715 MF 1 8-oxo-dGDP phosphatase activity 1 Q9UKK9 299 5.01e-03 1 2 1 0.500 1.000 OMIM:616420 omi 1 LEUKODYSTROPHY, HYPOMYELINATING, 10; HLD10 1 Q96C36 299 6.26e-03 3 2 1 0.500 0.333 GO:0004735 MF 1 pyrroline-5-carboxylate reductase activity 1 Q96C36 299 8.34e-03 467 2 2 1.000 0.004 TF:M01258_1 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 1 1 Q96C36,Q9UKK9 299 8.34e-03 4 2 1 0.500 0.250 GO:0009134 BP 1 nucleoside diphosphate catabolic process 1 Q9UKK9 299 8.34e-03 4 2 1 0.500 0.250 GO:0019323 BP 1 pentose catabolic process 1 Q9UKK9 299 8.34e-03 4 2 1 0.500 0.250 GO:0006561 BP 1 proline biosynthetic process 1 Q96C36 299 8.34e-03 4 2 1 0.500 0.250 GO:1990966 BP 1 ATP generation from poly-ADP-D-ribose 1 Q9UKK9 299 8.34e-03 4 2 1 0.500 0.250 GO:0009191 BP 1 ribonucleoside diphosphate catabolic process 1 Q9UKK9 299 1.17e-02 12 2 1 0.500 0.083 TF:M06604_0 tf 1 Factor: ZNF524; motif: KTGCTTYAGGGA; match class: 0 1 Q9UKK9 299 1.25e-02 6 2 1 0.500 0.167 GO:0034656 BP 1 nucleobase-containing small molecule catabolic process 1 Q9UKK9 299 1.47e-02 26 2 1 0.500 0.038 REAC:70614 rea 1 Amino acid synthesis and interconversion (transamination) 1 Q96C36 299 1.67e-02 8 2 1 0.500 0.125 GO:0070933 BP 1 histone H4 deacetylation 1 Q9UKK9 299 1.67e-02 8 2 1 0.500 0.125 GO:0017110 MF 1 nucleoside-diphosphatase activity 1 Q9UKK9 299 1.67e-02 8 2 1 0.500 0.125 GO:0019321 BP 1 pentose metabolic process 1 Q9UKK9 299 1.67e-02 8 2 1 0.500 0.125 GO:0006560 BP 1 proline metabolic process 1 Q96C36 299 1.88e-02 9 2 1 0.500 0.111 GO:0050072 MF 1 m7G(5')pppN diphosphatase activity 1 Q9UKK9 299 2.05e-02 21 2 1 0.500 0.048 TF:M05962_1 tf 1 Factor: PRDM16; motif: NGKGCCSGCMT; match class: 1 1 Q96C36 299 2.34e-02 24 2 1 0.500 0.042 TF:M05972_0 tf 1 Factor: ZNF701; motif: NTGGGGTGAARA; match class: 0 1 Q96C36 299 2.92e-02 14 2 1 0.500 0.071 GO:0009084 BP 1 glutamine family amino acid biosynthetic process 1 Q96C36 299 3.02e-02 31 2 1 0.500 0.032 TF:M05878_0 tf 1 Factor: ZNF100; motif: NTGGWGGGCGGA; match class: 0 1 Q96C36 299 3.54e-02 17 2 1 0.500 0.059 GO:0016646 MF 1 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1 Q96C36 299 3.70e-02 38 2 1 0.500 0.026 TF:M07093_0 tf 1 Factor: FoxH1; motif: NNSAATCCACA; match class: 0 1 Q9UKK9 299 3.90e-02 1010 2 2 1.000 0.002 TF:M03832_0 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 0 1 Q96C36,Q9UKK9 299 4.34e-02 59 2 1 0.500 0.017 HP:0003429 hp 1 CNS hypomyelination 1 Q96C36 299 4.38e-02 45 2 1 0.500 0.022 TF:M06227_0 tf 1 Factor: ZNF543; motif: NGGGAGGRGGTT; match class: 0 1 Q9UKK9 299 4.54e-02 1089 2 2 1.000 0.002 TF:M02073_0 tf 1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 0 1 Q96C36,Q9UKK9 299 5.00e-02 89 2 1 0.500 0.011 REAC:15869 rea 1 Metabolism of nucleotides 1 Q9UKK9 299 5.00e-02 43 2 1 0.500 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 Q96C36 299 5.00e-02 394 2 2 1.000 0.005 MI:hsa-miR-219-1-3p mi 1 MI:hsa-miR-219-1-3p 1 Q96C36,Q9UKK9 299 5.00e-02 1143 2 2 1.000 0.002 TF:M03977_0 tf 1 Factor: ETS1; motif: ACCGGAARYN; match class: 0 1 Q96C36,Q9UKK9 299 5.00e-02 24 2 1 0.500 0.042 GO:0016645 MF 1 oxidoreductase activity, acting on the CH-NH group of donors 1 Q96C36 299 5.00e-02 10 2 1 0.500 0.100 OMIM:312080 omi 1 Hypomyelinating Leukodystrophy 1 Q96C36 300 1.61e-03 511 2 2 1.000 0.004 TF:M04428_0 tf 1 Factor: PITX1; motif: NTTAATCCN; match class: 0 1 O43813,Q5HY92 300 6.13e-03 997 2 2 1.000 0.002 TF:M01112_0 tf 1 Factor: RBP-Jkappa; motif: ANCGTGGGAAM; match class: 0 1 O43813,Q5HY92 300 1.05e-02 67 2 1 0.500 0.015 TF:M06624_0 tf 1 Factor: ZNF2; motif: NSATCGATCCGA; match class: 0 1 Q5HY92 300 1.14e-02 1361 2 2 1.000 0.001 TF:M01661_0 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 0 1 O43813,Q5HY92 300 1.21e-02 1400 2 2 1.000 0.001 TF:M01111_0 tf 1 Factor: RBP-Jkappa; motif: TTCCCACK; match class: 0 1 O43813,Q5HY92 300 1.25e-02 80 2 1 0.500 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 Q5HY92 300 1.41e-02 90 2 1 0.500 0.011 TF:M06087_0 tf 1 Factor: ZNF21; motif: NANTCCTAAAGA; match class: 0 1 Q5HY92 300 1.67e-02 107 2 1 0.500 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 O43813 300 2.19e-02 1883 2 2 1.000 0.001 TF:M04505_0 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 0 1 O43813,Q5HY92 300 2.19e-02 1883 2 2 1.000 0.001 TF:M04623_0 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 0 1 O43813,Q5HY92 300 2.54e-02 163 2 1 0.500 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 O43813 300 2.59e-02 166 2 1 0.500 0.006 TF:M04505_1 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 1 1 O43813 300 2.59e-02 166 2 1 0.500 0.006 TF:M04623_1 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 1 1 O43813 300 2.68e-02 2084 2 2 1.000 0.001 TF:M04433_1 tf 1 Factor: PRRX2; motif: NYAATTAN; match class: 1 1 O43813,Q5HY92 300 3.00e-02 9 2 1 0.500 0.111 GO:0008568 MF 1 microtubule-severing ATPase activity 1 Q5HY92 300 3.00e-02 9 2 1 0.500 0.111 GO:0043295 MF 1 glutathione binding 1 O43813 300 3.04e-02 2218 2 2 1.000 0.001 TF:M04077_1 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 1 1 O43813,Q5HY92 300 3.22e-02 2283 2 2 1.000 0.001 TF:M04324_1 tf 1 Factor: GBX2; motif: NNYAATTANN; match class: 1 1 O43813,Q5HY92 300 3.27e-02 210 2 1 0.500 0.005 TF:M04326_1 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 1 1 O43813 300 3.33e-02 10 2 1 0.500 0.100 GO:1900750 MF 1 oligopeptide binding 1 O43813 300 3.86e-02 2500 2 2 1.000 0.001 TF:M01209_0 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 0 1 O43813,Q5HY92 300 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 O43813,Q5HY92 300 4.00e-02 12 2 1 0.500 0.083 GO:0050750 MF 1 low-density lipoprotein particle receptor binding 1 O43813 300 4.40e-02 283 2 1 0.500 0.004 TF:M00424_0 tf 1 Factor: Nkx6-1; motif: TWTTTAATTGGTT; match class: 0 1 O43813 300 4.67e-02 301 2 1 0.500 0.003 TF:M06188_0 tf 1 Factor: ZNF135; motif: NGTGGCTAMCGC; match class: 0 1 O43813 300 4.74e-02 305 2 1 0.500 0.003 TF:M00930_1 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 1 1 Q5HY92 300 5.00e-02 342 2 2 1.000 0.006 HPA:039020_03 hpa 1 soft tissue 1; chondrocytes[Uncertain,High] 1 O43813,Q5HY92 301 1.34e-05 3 6 2 0.333 0.667 GO:0035256 MF 1 G-protein coupled glutamate receptor binding 1 Q9NSB8,Q86YM7 301 2.44e-04 11 6 2 0.333 0.182 GO:0007216 BP 1 G-protein coupled glutamate receptor signaling pathway 1 Q9NSB8,Q86YM7 301 3.46e-04 13 6 2 0.333 0.154 GO:0035254 MF 1 glutamate receptor binding 1 Q9NSB8,Q86YM7 301 4.17e-03 44 6 2 0.333 0.045 GO:0007215 BP 1 glutamate receptor signaling pathway 1 Q9NSB8,Q86YM7 301 7.52e-03 59 6 2 0.333 0.034 GO:0007605 BP 1 sensory perception of sound 1 Q9NSB8,Q9H254 301 8.30e-03 62 6 2 0.333 0.032 GO:0050954 BP 1 sensory perception of mechanical stimulus 1 Q9NSB8,Q9H254 301 1.03e-02 1 6 1 0.167 1.000 GO:0043203 CC 1 axon hillock 1 Q9H254 301 1.43e-02 362 6 2 0.333 0.006 MI:hsa-miR-34b* mi 1 MI:hsa-miR-34b* 1 Q86YM7,Q9H254 301 1.57e-02 380 6 2 0.333 0.005 MI:hsa-miR-188-3p mi 1 MI:hsa-miR-188-3p 1 Q9NSB8,Q9H0V9 301 1.58e-02 381 6 2 0.333 0.005 MI:hsa-miR-511 mi 1 MI:hsa-miR-511 1 Q86YM7,Q9H254 301 1.61e-02 385 6 2 0.333 0.005 MI:mmu-miR-881 mi 1 MI:mmu-miR-881 1 Q9NSB8,Q86YM7 301 1.97e-02 428 6 2 0.333 0.005 MI:hsa-miR-193b mi 1 MI:hsa-miR-193b 1 O00463,Q9H254 301 2.04e-02 435 6 2 0.333 0.005 MI:hsa-miR-193a-3p mi 1 MI:hsa-miR-193a-3p 1 O00463,Q9H254 301 2.05e-02 2 6 1 0.167 0.500 GO:0070852 CC 1 cell body fiber 1 Q9H254 301 2.05e-02 2 6 1 0.167 0.500 GO:0032426 CC 1 stereocilium tip 1 Q9NSB8 301 2.05e-02 2 6 1 0.167 0.500 GO:2001256 BP 1 regulation of store-operated calcium entry 1 Q86YM7 301 2.05e-02 2 6 1 0.167 0.500 GO:0007206 BP 1 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway 1 Q86YM7 301 2.07e-02 98 6 2 0.333 0.020 GO:0001664 MF 1 G-protein coupled receptor binding 1 Q9NSB8,Q86YM7 301 2.21e-02 454 6 2 0.333 0.004 MI:hsa-miR-30d* mi 1 MI:hsa-miR-30d* 1 Q9NSB8,Q9H254 301 2.23e-02 457 6 2 0.333 0.004 MI:hsa-miR-744 mi 1 MI:hsa-miR-744 1 Q9NSB8,Q9H254 301 2.40e-02 475 6 2 0.333 0.004 MI:hsa-miR-103 mi 1 MI:hsa-miR-103 1 Q9H0V9,Q9H254 301 2.84e-02 115 6 2 0.333 0.017 GO:0005938 CC 1 cell cortex 1 O94915,Q9H254 301 3.08e-02 3 6 1 0.167 0.333 GO:0090659 BP 1 walking behavior 1 Q9H254 301 3.08e-02 3 6 1 0.167 0.333 GO:0045162 BP 1 clustering of voltage-gated sodium channels 1 Q9H254 301 3.08e-02 3 6 1 0.167 0.333 GO:0007628 BP 1 adult walking behavior 1 Q9H254 301 3.08e-02 3 6 1 0.167 0.333 GO:0010459 BP 1 negative regulation of heart rate 1 Q9H254 301 3.20e-02 122 6 2 0.333 0.016 GO:0099568 CC 1 cytoplasmic region 1 O94915,Q9H254 301 3.69e-02 95 6 2 0.333 0.021 KEGG:04724 keg 1 Glutamatergic synapse 1 Q9NSB8,Q86YM7 301 4.03e-02 626 6 2 0.333 0.003 MI:mmu-miR-291b-3p mi 1 MI:mmu-miR-291b-3p 1 O94915,Q9NSB8 301 4.05e-02 628 6 2 0.333 0.003 MI:hsa-miR-519b-3p mi 1 MI:hsa-miR-519b-3p 1 O94915,Q9NSB8 301 4.13e-02 635 6 2 0.333 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 O94915,Q9NSB8 301 4.50e-02 145 6 2 0.333 0.014 GO:0010959 BP 1 regulation of metal ion transport 1 Q86YM7,Q9H254 301 5.00e-02 111 6 2 0.333 0.018 KEGG:04068 keg 1 FoxO signaling pathway 1 Q9NSB8,Q86YM7 301 5.00e-02 119 6 2 0.333 0.017 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 Q9H0V9,Q9H254 302 1.41e-03 9 2 1 0.500 0.111 TF:M05992_0 tf 1 Factor: Zipro1; motif: NAGTGCTGCATM; match class: 0 1 Q9NRY5 302 4.03e-03 808 2 2 1.000 0.002 TF:M01796_0 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 0 1 Q9NRY5,Q9NW97 302 4.08e-03 26 2 1 0.500 0.038 TF:M06260_0 tf 1 Factor: ZNF91; motif: GTKAAGCCRM; match class: 0 1 Q9NRY5 302 8.00e-03 51 2 1 0.500 0.020 TF:M06981_0 tf 1 Factor: PRDM12; motif: NGACAGNTKACC; match class: 0 1 Q9NRY5 302 8.04e-03 1142 2 2 1.000 0.002 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 Q9NRY5,Q9NW97 302 1.02e-02 65 2 1 0.500 0.015 TF:M03927_1 tf 1 Factor: ZBTB7A; motif: NGCGACCACCNN; match class: 1 1 Q9NW97 302 1.03e-02 66 2 1 0.500 0.015 TF:M05546_1 tf 1 Factor: EOS; motif: TGGTTATM; match class: 1 1 Q9NRY5 302 1.11e-02 71 2 1 0.500 0.014 TF:M05556_0 tf 1 Factor: ZNF784; motif: WSTATAAAGAAA; match class: 0 1 Q9NRY5 302 1.24e-02 1418 2 2 1.000 0.001 TF:M07434_0 tf 1 Factor: TRPS1; motif: DGHHWCTATYTCCTD; match class: 0 1 Q9NRY5,Q9NW97 302 1.35e-02 86 2 1 0.500 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 Q9NRY5 302 1.55e-02 1583 2 2 1.000 0.001 TF:M00002_0 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 0 1 Q9NRY5,Q9NW97 302 1.71e-02 109 2 1 0.500 0.009 TF:M07098_1 tf 1 Factor: HNF-4gamma; motif: NNRGNNCAAAGKYCA; match class: 1 1 Q9NRY5 302 2.27e-02 1916 2 2 1.000 0.001 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 Q9NRY5,Q9NW97 302 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 Q9NW97 302 2.72e-02 174 2 1 0.500 0.006 TF:M06320_0 tf 1 Factor: ZNF791; motif: NGGTTATGAMGA; match class: 0 1 Q9NW97 302 2.95e-02 2187 2 2 1.000 0.001 TF:M00764_0 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 0 1 Q9NRY5,Q9NW97 302 2.96e-02 190 2 1 0.500 0.005 TF:M05904_0 tf 1 Factor: ZNF564; motif: GGGCAKCCGN; match class: 0 1 Q9NRY5 302 3.05e-02 2223 2 2 1.000 0.001 TF:M07258_0 tf 1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 0 1 Q9NRY5,Q9NW97 302 3.15e-02 202 2 1 0.500 0.005 TF:M06128_0 tf 1 Factor: ZNF3; motif: NGGGCCAACCGM; match class: 0 1 Q9NW97 302 3.38e-02 217 2 1 0.500 0.005 TF:M04307_1 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 1 1 Q9NRY5 302 3.43e-02 220 2 1 0.500 0.005 TF:M00134_1 tf 1 Factor: HNF4; motif: NNNRGGNCAAAGKTCANNN; match class: 1 1 Q9NRY5 302 3.71e-02 2451 2 2 1.000 0.001 TF:M00076_1 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 1 1 Q9NRY5,Q9NW97 302 3.73e-02 2459 2 2 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q9NRY5,Q9NW97 302 3.85e-02 2498 2 2 1.000 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 Q9NRY5,Q9NW97 302 3.85e-02 2498 2 2 1.000 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 Q9NRY5,Q9NW97 302 3.86e-02 248 2 1 0.500 0.004 TF:M03828_1 tf 1 Factor: HNF-4; motif: NNNNNNNGNNCAAAGKYCAN; match class: 1 1 Q9NRY5 302 4.01e-02 258 2 1 0.500 0.004 TF:M06275_0 tf 1 Factor: ZNF284; motif: NGGGGGTGGTGM; match class: 0 1 Q9NW97 302 4.07e-02 262 2 1 0.500 0.004 TF:M06887_1 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 1 1 Q9NW97 302 4.24e-02 2622 2 2 1.000 0.001 TF:M04072_0 tf 1 Factor: POU2F2; motif: NTATGCWAATN; match class: 0 1 Q9NRY5,Q9NW97 302 4.24e-02 273 2 1 0.500 0.004 TF:M05501_0 tf 1 Factor: ZBTB8B; motif: NRGGGGATAGN; match class: 0 1 Q9NRY5 302 4.25e-02 2624 2 2 1.000 0.001 TF:M04088_0 tf 1 Factor: POU5F1B; motif: TATGCWAAT; match class: 0 1 Q9NRY5,Q9NW97 302 4.29e-02 2637 2 2 1.000 0.001 TF:M07301_1 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 1 1 Q9NRY5,Q9NW97 302 4.49e-02 2697 2 2 1.000 0.001 TF:M07046_0 tf 1 Factor: LEF-1; motif: ANNWWCAAAGN; match class: 0 1 Q9NRY5,Q9NW97 302 4.51e-02 290 2 1 0.500 0.003 TF:M04233_1 tf 1 Factor: FOXC1; motif: NGTMAATATTKACN; match class: 1 1 Q9NRY5 302 4.55e-02 2715 2 2 1.000 0.001 TF:M01036_0 tf 1 Factor: COUPTF; motif: NNNNNTGACCYTTGNMCNYNGMN; match class: 0 1 Q9NRY5,Q9NW97 302 4.66e-02 300 2 1 0.500 0.003 TF:M01182_0 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 0 1 Q9NRY5 302 4.77e-02 2781 2 2 1.000 0.001 TF:M07421_1 tf 1 Factor: HOXC-8; motif: GAATWAYARN; match class: 1 1 Q9NRY5,Q9NW97 302 4.93e-02 318 2 1 0.500 0.003 TF:M03999_1 tf 1 Factor: GATA5; motif: WGATAANN; match class: 1 1 Q9NRY5 302 4.93e-02 318 2 1 0.500 0.003 TF:M07214_1 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 1 1 Q9NRY5 303 3.74e-08 2 2 2 1.000 1.000 GO:0016403 MF 1 dimethylargininase activity 1 O94760,O95865 303 5.61e-07 6 2 2 1.000 0.333 GO:0016813 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1 O94760,O95865 303 5.61e-07 6 2 2 1.000 0.333 GO:0000052 BP 1 citrulline metabolic process 1 O94760,O95865 303 1.35e-06 9 2 2 1.000 0.222 GO:0006527 BP 1 arginine catabolic process 1 O94760,O95865 303 1.38e-06 9 2 2 1.000 0.222 REAC:203615 rea 1 eNOS activation 1 O94760,O95865 303 2.92e-06 13 2 2 1.000 0.154 GO:0006525 BP 1 arginine metabolic process 1 O94760,O95865 303 4.49e-06 16 2 2 1.000 0.125 GO:0007263 BP 1 nitric oxide mediated signal transduction 1 O94760,O95865 303 5.09e-06 17 2 2 1.000 0.118 GO:1904407 BP 1 positive regulation of nitric oxide metabolic process 1 O94760,O95865 303 5.09e-06 17 2 2 1.000 0.118 GO:0045429 BP 1 positive regulation of nitric oxide biosynthetic process 1 O94760,O95865 303 6.40e-06 19 2 2 1.000 0.105 GO:0009065 BP 1 glutamine family amino acid catabolic process 1 O94760,O95865 303 6.55e-06 19 2 2 1.000 0.105 REAC:203765 rea 1 eNOS activation and regulation 1 O94760,O95865 303 6.55e-06 19 2 2 1.000 0.105 REAC:202131 rea 1 Metabolism of nitric oxide 1 O94760,O95865 303 7.11e-06 20 2 2 1.000 0.100 GO:1903428 BP 1 positive regulation of reactive oxygen species biosynthetic process 1 O94760,O95865 303 8.65e-06 22 2 2 1.000 0.091 GO:0045428 BP 1 regulation of nitric oxide biosynthetic process 1 O94760,O95865 303 1.52e-05 29 2 2 1.000 0.069 GO:0050999 BP 1 regulation of nitric-oxide synthase activity 1 O94760,O95865 303 1.63e-05 30 2 2 1.000 0.067 GO:1903426 BP 1 regulation of reactive oxygen species biosynthetic process 1 O94760,O95865 303 1.63e-05 30 2 2 1.000 0.067 GO:0006809 BP 1 nitric oxide biosynthetic process 1 O94760,O95865 303 1.86e-05 32 2 2 1.000 0.062 GO:0046209 BP 1 nitric oxide metabolic process 1 O94760,O95865 303 2.10e-05 34 2 2 1.000 0.059 GO:2001057 BP 1 reactive nitrogen species metabolic process 1 O94760,O95865 303 2.36e-05 36 2 2 1.000 0.056 GO:0032768 BP 1 regulation of monooxygenase activity 1 O94760,O95865 303 3.07e-05 41 2 2 1.000 0.049 GO:1903409 BP 1 reactive oxygen species biosynthetic process 1 O94760,O95865 303 3.22e-05 42 2 2 1.000 0.048 GO:0009064 BP 1 glutamine family amino acid metabolic process 1 O94760,O95865 303 3.71e-05 45 2 2 1.000 0.044 GO:2000379 BP 1 positive regulation of reactive oxygen species metabolic process 1 O94760,O95865 303 5.16e-05 53 2 2 1.000 0.038 GO:0051341 BP 1 regulation of oxidoreductase activity 1 O94760,O95865 303 1.04e-04 75 2 2 1.000 0.027 GO:1901606 BP 1 alpha-amino acid catabolic process 1 O94760,O95865 303 1.12e-04 78 2 2 1.000 0.026 GO:2000377 BP 1 regulation of reactive oxygen species metabolic process 1 O94760,O95865 303 1.60e-04 93 2 2 1.000 0.022 GO:0009063 BP 1 cellular amino acid catabolic process 1 O94760,O95865 303 1.82e-04 99 2 2 1.000 0.020 GO:0016810 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 O94760,O95865 303 2.72e-04 121 2 2 1.000 0.017 GO:0072593 BP 1 reactive oxygen species metabolic process 1 O94760,O95865 303 2.95e-04 126 2 2 1.000 0.016 GO:0019932 BP 1 second-messenger-mediated signaling 1 O94760,O95865 303 4.41e-04 154 2 2 1.000 0.013 GO:1901605 BP 1 alpha-amino acid metabolic process 1 O94760,O95865 303 5.57e-04 173 2 2 1.000 0.012 GO:0016054 BP 1 organic acid catabolic process 1 O94760,O95865 303 5.57e-04 173 2 2 1.000 0.012 GO:0046395 BP 1 carboxylic acid catabolic process 1 O94760,O95865 303 1.13e-03 246 2 2 1.000 0.008 GO:0044282 BP 1 small molecule catabolic process 1 O94760,O95865 303 1.32e-03 266 2 2 1.000 0.008 GO:1901565 BP 1 organonitrogen compound catabolic process 1 O94760,O95865 303 1.49e-03 283 2 2 1.000 0.007 GO:0006520 BP 1 cellular amino acid metabolic process 1 O94760,O95865 303 2.05e-03 508 2 2 1.000 0.004 MI:hsa-miR-509-3p mi 1 MI:hsa-miR-509-3p 1 O94760,O95865 303 6.11e-03 572 2 2 1.000 0.003 GO:0044712 BP 1 single-organism catabolic process 1 O94760,O95865 303 7.90e-03 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 O94760,O95865 303 9.93e-03 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 O94760,O95865 303 1.02e-02 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 O94760,O95865 303 1.34e-02 31 2 1 0.500 0.032 GO:0003073 BP 1 regulation of systemic arterial blood pressure 1 O94760 303 1.71e-02 956 2 2 1.000 0.002 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 O94760,O95865 303 1.76e-02 971 2 2 1.000 0.002 GO:0009891 BP 1 positive regulation of biosynthetic process 1 O94760,O95865 303 1.84e-02 993 2 2 1.000 0.002 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 O94760,O95865 303 2.14e-02 1071 2 2 1.000 0.002 GO:0050790 BP 1 regulation of catalytic activity 1 O94760,O95865 303 2.37e-02 55 2 1 0.500 0.018 GO:0008217 BP 1 regulation of blood pressure 1 O94760 303 2.43e-02 1141 2 2 1.000 0.002 GO:0044248 BP 1 cellular catabolic process 1 O94760,O95865 303 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 O94760,O95865 303 3.11e-02 1290 2 2 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 O94760,O95865 303 3.32e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 O94760,O95865 303 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 O94760,O95865 303 3.47e-02 1362 2 2 1.000 0.001 GO:0009056 BP 1 catabolic process 1 O94760,O95865 303 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 O94760,O95865 303 3.60e-02 1388 2 2 1.000 0.001 GO:0065009 BP 1 regulation of molecular function 1 O94760,O95865 303 3.87e-02 219 2 1 0.500 0.005 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 O95865 303 3.95e-02 2146 2 2 1.000 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 O94760,O95865 303 4.24e-02 240 2 1 0.500 0.004 MI:hsa-miR-25* mi 1 MI:hsa-miR-25* 1 O95865 303 4.40e-02 1533 2 2 1.000 0.001 GO:0035556 BP 1 intracellular signal transduction 1 O94760,O95865 303 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 O95865 303 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 O94760,O95865 303 4.45e-02 252 2 1 0.500 0.004 MI:hsa-miR-130b* mi 1 MI:hsa-miR-130b* 1 O95865 303 4.57e-02 259 2 1 0.500 0.004 MI:hsa-miR-191* mi 1 MI:hsa-miR-191* 1 O95865 303 4.58e-02 1565 2 2 1.000 0.001 GO:1901564 BP 1 organonitrogen compound metabolic process 1 O94760,O95865 303 4.59e-02 260 2 1 0.500 0.004 MI:mmu-miR-207 mi 1 MI:mmu-miR-207 1 O95865 303 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 O95865 303 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-877* mi 1 MI:hsa-miR-877* 1 O95865 303 4.83e-02 1607 2 2 1.000 0.001 GO:0016787 MF 1 hydrolase activity 1 O94760,O95865 303 4.97e-02 282 2 1 0.500 0.004 MI:hsa-miR-367* mi 1 MI:hsa-miR-367* 1 O95865 303 5.00e-02 1635 2 2 1.000 0.001 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 O94760,O95865 303 5.00e-02 143 2 2 1.000 0.014 TF:M04202_0 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 0 1 O94760,O95865 304 7.83e-04 1 2 1 0.500 1.000 GO:0098838 BP 1 reduced folate transmembrane transport 1 P41440 304 7.83e-04 1 2 1 0.500 1.000 GO:0008518 MF 1 reduced folate carrier activity 1 P41440 304 1.57e-03 2 2 1 0.500 0.500 GO:0015350 MF 1 methotrexate transporter activity 1 P41440 304 2.35e-03 3 2 1 0.500 0.333 GO:0015884 BP 1 folic acid transport 1 P41440 304 3.13e-03 4 2 1 0.500 0.250 GO:0005542 MF 1 folic acid binding 1 P41440 304 3.13e-03 4 2 1 0.500 0.250 GO:0008517 MF 1 folic acid transporter activity 1 P41440 304 6.40e-03 16 2 1 0.500 0.062 REAC:196757 rea 1 Metabolism of folate and pterines 1 P41440 304 7.83e-03 10 2 1 0.500 0.100 GO:0051181 BP 1 cofactor transport 1 P41440 304 8.61e-03 11 2 1 0.500 0.091 GO:0051183 MF 1 vitamin transporter activity 1 P41440 304 8.61e-03 11 2 1 0.500 0.091 GO:0090484 MF 1 drug transporter activity 1 P41440 304 1.10e-02 14 2 1 0.500 0.071 GO:0072337 BP 1 modified amino acid transport 1 P41440 304 1.10e-02 14 2 1 0.500 0.071 GO:0051180 BP 1 vitamin transport 1 P41440 304 1.25e-02 16 2 1 0.500 0.062 GO:0046655 BP 1 folic acid metabolic process 1 P41440 304 1.33e-02 17 2 1 0.500 0.059 GO:0051184 MF 1 cofactor transporter activity 1 P41440 304 1.49e-02 19 2 1 0.500 0.053 GO:0019842 MF 1 vitamin binding 1 P41440 304 1.57e-02 20 2 1 0.500 0.050 GO:0006760 BP 1 folic acid-containing compound metabolic process 1 P41440 304 1.80e-02 7 2 1 0.500 0.143 TF:M04106_1 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 1 P41440 304 1.88e-02 24 2 1 0.500 0.042 GO:0042558 BP 1 pteridine-containing compound metabolic process 1 P41440 304 2.30e-02 477 2 2 1.000 0.004 TF:M05304_0 tf 1 Factor: Zbtb5; motif: AGGRAGCTTC; match class: 0 1 P41440,Q6UWJ8 304 2.74e-02 35 2 1 0.500 0.029 GO:0072341 MF 1 modified amino acid binding 1 P41440 304 2.89e-02 15 2 1 0.500 0.067 KEGG:04977 keg 1 Vitamin digestion and absorption 1 P41440 304 2.89e-02 37 2 1 0.500 0.027 GO:0006835 BP 1 dicarboxylic acid transport 1 P41440 304 3.42e-02 86 2 1 0.500 0.012 REAC:196849 rea 1 Metabolism of water-soluble vitamins and cofactors 1 P41440 304 3.87e-02 15 2 1 0.500 0.067 TF:M06048_0 tf 1 Factor: ZNF208; motif: NGNKGAAGTTGC; match class: 0 1 P41440 304 4.26e-02 362 2 2 1.000 0.006 MI:hsa-miR-339-5p mi 1 MI:hsa-miR-339-5p 1 P41440,Q6UWJ8 304 5.00e-02 703 2 2 1.000 0.003 TF:M00176_1 tf 1 Factor: AP-4; motif: CWCAGCTGGN; match class: 1 1 P41440,Q6UWJ8 304 5.00e-02 26 2 1 0.500 0.038 KEGG:01523 keg 1 Antifolate resistance 1 P41440 304 5.00e-02 126 2 1 0.500 0.008 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P41440 304 5.00e-02 392 2 2 1.000 0.005 MI:mmu-miR-702 mi 1 MI:mmu-miR-702 1 P41440,Q6UWJ8 304 5.00e-02 64 2 1 0.500 0.016 GO:0043648 BP 1 dicarboxylic acid metabolic process 1 P41440 305 3.88e-09 3 10 3 0.300 1.000 GO:1990423 CC 1 RZZ complex 1 O43264,Q9H900,P50748 305 1.86e-06 183 10 5 0.500 0.027 GO:0000075 BP 1 cell cycle checkpoint 1 O43264,Q6NUQ1,Q9H900,Q13535,P50748 305 1.68e-05 3 10 2 0.200 0.667 GO:0070939 CC 1 Dsl1/NZR complex 1 O43264,Q6NUQ1 305 2.38e-05 128 10 4 0.400 0.031 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 O43264,Q6NUQ1,Q9H900,P50748 305 6.52e-05 376 10 5 0.500 0.013 GO:0045786 BP 1 negative regulation of cell cycle 1 O43264,Q6NUQ1,Q9H900,Q13535,P50748 305 7.37e-05 170 10 4 0.400 0.024 GO:0045930 BP 1 negative regulation of mitotic cell cycle 1 O43264,Q6NUQ1,Q9H900,P50748 305 8.36e-05 6 10 2 0.200 0.333 GO:0005828 CC 1 kinetochore microtubule 1 O43264,P50748 305 9.86e-05 3 10 2 0.200 0.667 CORUM:705 cor 1 SNARE complex (RINT1, ZW10, p31) 1 O43264,Q6NUQ1 305 2.43e-04 230 10 4 0.400 0.017 GO:0098687 CC 1 chromosomal region 1 O43264,Q9H900,Q13535,P50748 305 4.34e-04 13 10 2 0.200 0.154 GO:0007096 BP 1 regulation of exit from mitosis 1 O43264,P50748 305 4.52e-04 91 10 3 0.300 0.033 GO:0000776 CC 1 kinetochore 1 O43264,Q9H900,P50748 305 9.33e-04 116 10 3 0.300 0.026 GO:0007062 BP 1 sister chromatid cohesion 1 O43264,Q9H900,P50748 305 1.01e-03 99 10 3 0.300 0.030 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 O43264,Q9H900,P50748 305 1.06e-03 121 10 3 0.300 0.025 GO:0000775 CC 1 chromosome, centromeric region 1 O43264,Q9H900,P50748 305 1.13e-03 679 10 5 0.500 0.007 GO:0051726 BP 1 regulation of cell cycle 1 O43264,Q6NUQ1,Q9H900,Q13535,P50748 305 1.28e-03 107 10 3 0.300 0.028 REAC:68877 rea 1 Mitotic Prometaphase 1 O43264,Q9H900,P50748 305 1.44e-03 363 10 4 0.400 0.011 GO:0007346 BP 1 regulation of mitotic cell cycle 1 O43264,Q6NUQ1,Q9H900,P50748 305 1.50e-03 113 10 3 0.300 0.027 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 O43264,Q9H900,P50748 305 1.53e-03 24 10 2 0.200 0.083 GO:0010458 BP 1 exit from mitosis 1 O43264,P50748 305 3.18e-03 446 10 4 0.400 0.009 GO:0051276 BP 1 chromosome organization 1 O43264,Q9H900,Q13535,P50748 305 4.22e-03 161 10 3 0.300 0.019 REAC:2467813 rea 1 Separation of Sister Chromatids 1 O43264,Q9H900,P50748 305 4.38e-03 196 10 3 0.300 0.015 GO:0000819 BP 1 sister chromatid segregation 1 O43264,Q9H900,P50748 305 5.11e-03 172 10 3 0.300 0.017 REAC:68882 rea 1 Mitotic Anaphase 1 O43264,Q9H900,P50748 305 5.18e-03 44 10 2 0.200 0.045 GO:0099023 CC 1 tethering complex 1 O43264,Q6NUQ1 305 5.19e-03 173 10 3 0.300 0.017 REAC:2555396 rea 1 Mitotic Metaphase and Anaphase 1 O43264,Q9H900,P50748 305 6.17e-03 48 10 2 0.200 0.042 GO:0005876 CC 1 spindle microtubule 1 O43264,P50748 305 6.64e-03 226 10 3 0.300 0.013 GO:0098813 BP 1 nuclear chromosome segregation 1 O43264,Q9H900,P50748 305 7.16e-03 1 10 1 0.100 1.000 GO:1904289 BP 1 regulation of mitotic DNA damage checkpoint 1 Q6NUQ1 305 7.16e-03 1 10 1 0.100 1.000 GO:1902504 BP 1 regulation of signal transduction involved in mitotic G2 DNA damage checkpoint 1 Q6NUQ1 305 7.22e-03 1 10 1 0.100 1.000 OMIM:614564 omi 1 CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL; FCTCS;;TELANGIECTASIA, CUTANEOUS, AND CANCER SYNDROME, FAMILIAL 1 Q13535 305 7.35e-03 234 10 3 0.300 0.013 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 O43264,Q6NUQ1,P50748 305 7.80e-03 565 10 4 0.400 0.007 GO:0044427 CC 1 chromosomal part 1 O43264,Q9H900,Q13535,P50748 305 8.10e-03 55 10 2 0.200 0.036 GO:0034502 BP 1 protein localization to chromosome 1 O43264,Q13535 305 8.20e-03 243 10 3 0.300 0.012 GO:1901987 BP 1 regulation of cell cycle phase transition 1 O43264,Q6NUQ1,P50748 305 1.03e-02 263 10 3 0.300 0.011 GO:0007059 BP 1 chromosome segregation 1 O43264,Q9H900,P50748 305 1.03e-02 609 10 4 0.400 0.007 GO:0005694 CC 1 chromosome 1 O43264,Q9H900,Q13535,P50748 305 1.19e-02 231 10 3 0.300 0.013 REAC:195258 rea 1 RHO GTPase Effectors 1 O43264,Q9H900,P50748 305 1.21e-02 1128 10 5 0.500 0.004 GO:0007049 BP 1 cell cycle 1 O43264,Q6NUQ1,Q9H900,Q13535,P50748 305 1.37e-02 657 10 4 0.400 0.006 GO:1903047 BP 1 mitotic cell cycle process 1 O43264,Q6NUQ1,Q9H900,P50748 305 1.43e-02 2 10 1 0.100 0.500 GO:0072434 BP 1 signal transduction involved in mitotic G2 DNA damage checkpoint 1 Q6NUQ1 305 1.43e-02 2 10 1 0.100 0.500 GO:1904882 BP 1 regulation of telomerase catalytic core complex assembly 1 Q13535 305 1.43e-02 2 10 1 0.100 0.500 GO:1905323 BP 1 telomerase holoenzyme complex assembly 1 Q13535 305 1.43e-02 2 10 1 0.100 0.500 GO:0072425 BP 1 signal transduction involved in G2 DNA damage checkpoint 1 Q6NUQ1 305 1.43e-02 2 10 1 0.100 0.500 GO:1904868 BP 1 telomerase catalytic core complex assembly 1 Q13535 305 1.43e-02 2 10 1 0.100 0.500 GO:1904884 BP 1 positive regulation of telomerase catalytic core complex assembly 1 Q13535 305 1.50e-02 75 10 2 0.200 0.027 GO:0006890 BP 1 retrograde vesicle-mediated transport, Golgi to ER 1 O43264,Q6NUQ1 305 1.54e-02 253 10 3 0.300 0.012 REAC:68886 rea 1 M Phase 1 O43264,Q9H900,P50748 305 1.58e-02 77 10 2 0.200 0.026 GO:0000922 CC 1 spindle pole 1 O43264,P50748 305 1.68e-02 2 10 1 0.100 0.500 CORUM:265 cor 1 ATR-ATRIP complex 1 Q13535 305 1.68e-02 2 10 1 0.100 0.500 CORUM:1133 cor 1 ATR-HDAC2 complex 1 Q13535 305 1.71e-02 547 10 4 0.400 0.007 REAC:1640170 rea 1 Cell Cycle 1 O43264,Q9H900,Q13535,P50748 305 1.78e-02 78 10 2 0.200 0.026 REAC:6811434 rea 1 COPI-dependent Golgi-to-ER retrograde traffic 1 O43264,Q6NUQ1 305 1.94e-02 721 10 4 0.400 0.006 GO:0000278 BP 1 mitotic cell cycle 1 O43264,Q6NUQ1,Q9H900,P50748 305 2.15e-02 3 10 1 0.100 0.333 GO:1990253 BP 1 cellular response to leucine starvation 1 Q92616 305 2.15e-02 3 10 1 0.100 0.333 GO:0097695 BP 1 establishment of macromolecular complex localization to telomere 1 Q13535 305 2.15e-02 3 10 1 0.100 0.333 GO:0032407 MF 1 MutSalpha complex binding 1 Q13535 305 2.15e-02 3 10 1 0.100 0.333 GO:0097694 BP 1 establishment of RNA localization to telomere 1 Q13535 305 2.22e-02 1960 10 6 0.600 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 O43264,Q92616,Q96QU8,Q9H900,Q13535,P50748 305 2.22e-02 1960 10 6 0.600 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 O43264,Q92616,Q96QU8,Q9H900,Q13535,P50748 305 2.32e-02 371 10 3 0.300 0.008 MI:mmu-miR-696 mi 1 MI:mmu-miR-696 1 Q92616,Q96QU8,P50748 305 2.42e-02 7443 10 10 1.000 0.001 HPA:017010_01 hpa 1 heart muscle; myocytes[Uncertain,Low] 1 O43264,Q92616,O43156,Q08AM6,Q9UFG5,Q6NUQ1,Q96QU8,Q9H900,Q13535,P50748 305 2.51e-02 3 10 1 0.100 0.333 CORUM:1134 cor 1 ATR-HDAC2-CHD4 complex 1 Q13535 305 2.59e-02 99 10 2 0.200 0.020 GO:0042770 BP 1 signal transduction in response to DNA damage 1 Q6NUQ1,Q13535 305 2.69e-02 101 10 2 0.200 0.020 GO:0007088 BP 1 regulation of mitotic nuclear division 1 O43264,P50748 305 2.86e-02 4 10 1 0.100 0.250 GO:0032405 MF 1 MutLalpha complex binding 1 Q13535 305 2.86e-02 4 10 1 0.100 0.250 GO:0019237 MF 1 centromeric DNA binding 1 O43264 305 2.94e-02 8 10 1 0.100 0.125 HP:0006442 hp 1 Hypoplasia of proximal fibula 1 Q13535 305 2.94e-02 8 10 1 0.100 0.125 HP:0007048 hp 1 Large basal ganglia 1 Q13535 305 2.94e-02 8 10 1 0.100 0.125 HP:0010455 hp 1 Steep acetabular roof 1 Q13535 305 3.02e-02 107 10 2 0.200 0.019 GO:0051783 BP 1 regulation of nuclear division 1 O43264,P50748 305 3.14e-02 413 10 3 0.300 0.007 MI:hsa-miR-541 mi 1 MI:hsa-miR-541 1 O43156,Q08AM6,Q96QU8 305 3.25e-02 280 10 3 0.300 0.011 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 O43264,Q08AM6,Q13535 305 3.29e-02 107 10 2 0.200 0.019 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 O43264,Q6NUQ1 305 3.30e-02 9 10 1 0.100 0.111 HP:0030148 hp 1 Heart murmur 1 Q13535 305 3.30e-02 9 10 1 0.100 0.111 HP:0006434 hp 1 Hypoplasia of proximal radius 1 Q13535 305 3.46e-02 338 10 3 0.300 0.009 REAC:194315 rea 1 Signaling by Rho GTPases 1 O43264,Q9H900,P50748 305 3.47e-02 402 10 3 0.300 0.007 GO:0010564 BP 1 regulation of cell cycle process 1 O43264,Q6NUQ1,P50748 305 3.57e-02 5 10 1 0.100 0.200 GO:0060628 BP 1 regulation of ER to Golgi vesicle-mediated transport 1 Q6NUQ1 305 3.59e-02 117 10 2 0.200 0.017 GO:0033044 BP 1 regulation of chromosome organization 1 O43264,Q13535 305 3.59e-02 117 10 2 0.200 0.017 GO:1901991 BP 1 negative regulation of mitotic cell cycle phase transition 1 O43264,Q6NUQ1 305 3.67e-02 10 10 1 0.100 0.100 HP:0011342 hp 1 Mild global developmental delay 1 Q13535 305 3.69e-02 411 10 3 0.300 0.007 GO:0044772 BP 1 mitotic cell cycle phase transition 1 O43264,Q6NUQ1,P50748 305 3.70e-02 438 10 3 0.300 0.007 MI:gga-miR-757 mi 1 MI:gga-miR-757 1 Q92616,Q08AM6,Q9H900 305 3.72e-02 119 10 2 0.200 0.017 GO:2001020 BP 1 regulation of response to DNA damage stimulus 1 Q6NUQ1,Q13535 305 3.78e-02 120 10 2 0.200 0.017 GO:1901988 BP 1 negative regulation of cell cycle phase transition 1 O43264,Q6NUQ1 305 4.06e-02 425 10 3 0.300 0.007 GO:0044770 BP 1 cell cycle phase transition 1 O43264,Q6NUQ1,P50748 305 4.09e-02 125 10 2 0.200 0.016 GO:0000077 BP 1 DNA damage checkpoint 1 Q6NUQ1,Q13535 305 4.29e-02 6 10 1 0.100 0.167 GO:0032404 MF 1 mismatch repair complex binding 1 Q13535 305 4.38e-02 12 10 1 0.100 0.083 HP:0007429 hp 1 Few cafe-au-lait spots 1 Q13535 305 4.58e-02 473 10 3 0.300 0.006 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 Q92616,O43156,Q6NUQ1 305 4.74e-02 13 10 1 0.100 0.077 HP:0003683 hp 1 Large beaked nose 1 Q13535 305 4.75e-02 135 10 2 0.200 0.015 GO:0031570 BP 1 DNA integrity checkpoint 1 Q6NUQ1,Q13535 305 5.00e-02 488 10 3 0.300 0.006 MI:hsa-miR-155 mi 1 MI:hsa-miR-155 1 O43264,Q9H900,P50748 305 5.00e-02 6 10 1 0.100 0.167 CORUM:1182 cor 1 CDC5L core complex 1 Q92616 305 5.00e-02 10 10 1 0.100 0.100 REAC:1660517 rea 1 Synthesis of PIPs at the late endosome membrane 1 Q08AM6 305 5.00e-02 325 10 3 0.300 0.009 TF:M04289_0 tf 1 Factor: BARHL2; motif: TAAWYGNYNNTAAWYG; match class: 0 1 Q96QU8,Q9H900,Q13535 305 5.00e-02 7 10 1 0.100 0.143 GO:0031931 CC 1 TORC1 complex 1 O43156 305 5.00e-02 7 10 1 0.100 0.143 OMIM:210600 omi 1 Seckel Syndrome 1 Q13535 306 2.20e-03 7 4 1 0.250 0.143 TF:M04250_0 tf 1 Factor: FOXJ3; motif: GTAAACARTAAACA; match class: 0 1 Q5VWN6 306 3.14e-03 10 4 1 0.250 0.100 TF:M05898_0 tf 1 Factor: ZSCAN4; motif: TGTTAATCCAAA; match class: 0 1 Q5VWN6 306 4.92e-03 1404 4 3 0.750 0.002 TF:M03901_0 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 0 1 Q9UK61,Q96LX8,Q99549 306 5.96e-03 19 4 1 0.250 0.053 TF:M05896_0 tf 1 Factor: ZNF713; motif: NGGGTTAWAATS; match class: 0 1 Q5VWN6 306 6.40e-03 1537 4 3 0.750 0.002 TF:M00491_0 tf 1 Factor: MAZR; motif: NSGGGGGGGGMCN; match class: 0 1 Q5VWN6,Q9UK61,Q99549 306 6.78e-03 1568 4 3 0.750 0.002 TF:M03815_1 tf 1 Factor: c-Fos; motif: TGACTCAN; match class: 1 1 Q5VWN6,Q96LX8,Q99549 306 8.00e-03 477 4 2 0.500 0.004 TF:M01197_1 tf 1 Factor: Elf5; motif: WNAAGGAARTW; match class: 1 1 Q96LX8,Q99549 306 1.10e-02 563 4 2 0.500 0.004 TF:M07427_0 tf 1 Factor: NURR1; motif: AAAGGTCANN; match class: 0 1 Q9UK61,Q99549 306 1.13e-02 36 4 1 0.250 0.028 TF:M04161_1 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 1 1 Q9UK61 306 1.13e-02 36 4 1 0.250 0.028 TF:M04161_0 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 0 1 Q9UK61 306 1.19e-02 585 4 2 0.500 0.003 TF:M02085_1 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 1 1 Q9UK61,Q99549 306 1.22e-02 39 4 1 0.250 0.026 TF:M04246_0 tf 1 Factor: FOXJ2; motif: GTAAACARTAAACA; match class: 0 1 Q5VWN6 306 1.47e-02 47 4 1 0.250 0.021 TF:M01796_1 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 1 1 Q99549 306 1.48e-02 4441 4 4 1.000 0.001 TF:M04063_1 tf 1 Factor: Pax-4; motif: SWAATWAN; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 1.56e-02 50 4 1 0.250 0.020 TF:M06161_0 tf 1 Factor: ZNF117; motif: NGGGGAGGACGM; match class: 0 1 Q99549 306 1.56e-02 50 4 1 0.250 0.020 TF:M06353_0 tf 1 Factor: ZNF782; motif: NGGGRGGGCAAWMK; match class: 0 1 Q5VWN6 306 1.63e-02 688 4 2 0.500 0.003 TF:M07124_0 tf 1 Factor: AML3; motif: KNKNTYTGTGGTTTK; match class: 0 1 Q5VWN6,Q99549 306 1.70e-02 703 4 2 0.500 0.003 TF:M03872_1 tf 1 Factor: HNF-1beta; motif: GTTAATYATTAACY; match class: 1 1 Q5VWN6,Q99549 306 1.93e-02 62 4 1 0.250 0.016 TF:M04055_0 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 0 1 Q9UK61 306 1.93e-02 62 4 1 0.250 0.016 TF:M04055_1 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 1 1 Q9UK61 306 1.98e-02 4778 4 4 1.000 0.001 TF:M00160_1 tf 1 Factor: SRY; motif: NWWAACAAWANN; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 2.08e-02 2317 4 3 0.750 0.001 TF:M00920_0 tf 1 Factor: E2F; motif: NKCGCGCSAAAN; match class: 0 1 Q9UK61,Q96LX8,Q99549 306 2.12e-02 68 4 1 0.250 0.015 TF:M05727_0 tf 1 Factor: ZNF674; motif: NGTTMAAAAAWA; match class: 0 1 Q9UK61 306 2.24e-02 397 4 2 0.500 0.005 MI:hsa-miR-200a* mi 1 MI:hsa-miR-200a* 1 Q96LX8,Q99549 306 2.55e-02 82 4 1 0.250 0.012 TF:M04109_0 tf 1 Factor: RUNX3; motif: NRACCGCAAACCGCAN; match class: 0 1 Q99549 306 2.71e-02 5164 4 4 1.000 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 2.80e-02 90 4 1 0.250 0.011 TF:M00423_1 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 1 Q99549 306 2.89e-02 2601 4 3 0.750 0.001 TF:M02280_1 tf 1 Factor: AP1; motif: TGACTCA; match class: 1 1 Q5VWN6,Q96LX8,Q99549 306 2.89e-02 93 4 1 0.250 0.011 TF:M05540_0 tf 1 Factor: ZBTB34; motif: NATAGGRATAT; match class: 0 1 Q5VWN6 306 2.97e-02 5285 4 4 1.000 0.001 TF:M02052_1 tf 1 Factor: EHF; motif: CSCGGAARTN; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 2.98e-02 459 4 2 0.500 0.004 MI:hsa-miR-299-5p mi 1 MI:hsa-miR-299-5p 1 Q96LX8,Q99549 306 3.32e-02 107 4 1 0.250 0.009 TF:M03946_0 tf 1 Factor: GRHL1; motif: AACCGGTNNAACCGGTT; match class: 0 1 Q5VWN6 306 3.37e-02 1007 4 2 0.500 0.002 TF:M03974_0 tf 1 Factor: ERF; motif: ACCGGAAGTR; match class: 0 1 Q5VWN6,Q96LX8 306 3.38e-02 109 4 1 0.250 0.009 TF:M03934_0 tf 1 Factor: ZBTB18; motif: NATCCAGATGTKN; match class: 0 1 Q96LX8 306 3.50e-02 872 4 2 0.500 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 Q5VWN6,Q99549 306 3.53e-02 501 4 2 0.500 0.004 MI:mmu-miR-467e mi 1 MI:mmu-miR-467e 1 Q5VWN6,Q96LX8 306 3.54e-02 2797 4 3 0.750 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q5VWN6,Q9UK61,Q99549 306 3.60e-02 5544 4 4 1.000 0.001 TF:M00983_0 tf 1 Factor: MAF; motif: NGCTGAGTCAN; match class: 0 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 3.72e-02 515 4 2 0.500 0.004 MI:hsa-miR-30a mi 1 MI:hsa-miR-30a 1 Q5VWN6,Q9UK61 306 3.76e-02 5607 4 4 1.000 0.001 TF:M00350_0 tf 1 Factor: GATA-3; motif: NGAGATAANA; match class: 0 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 3.81e-02 1075 4 2 0.500 0.002 TF:M04291_0 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 0 1 Q9UK61,Q99549 306 3.82e-02 1076 4 2 0.500 0.002 TF:M00623_1 tf 1 Factor: Crx; motif: YNNNTAATCYSMN; match class: 1 1 Q9UK61,Q99549 306 3.85e-02 2880 4 3 0.750 0.001 TF:M00088_1 tf 1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 1 Q5VWN6,Q9UK61,Q99549 306 3.91e-02 528 4 2 0.500 0.004 MI:mmu-miR-883a-3p mi 1 MI:mmu-miR-883a-3p 1 Q5VWN6,Q99549 306 3.92e-02 1091 4 2 0.500 0.002 TF:M00302_1 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 1 1 Q9UK61,Q99549 306 3.93e-02 5668 4 4 1.000 0.001 TF:M03815_0 tf 1 Factor: c-Fos; motif: TGACTCAN; match class: 0 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 4.10e-02 2948 4 3 0.750 0.001 TF:M00087_1 tf 1 Factor: Ik-2; motif: NNNTGGGAWNNC; match class: 1 1 Q5VWN6,Q9UK61,Q99549 306 4.12e-02 2953 4 3 0.750 0.001 TF:M00231_0 tf 1 Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 0 1 Q5VWN6,Q9UK61,Q96LX8 306 4.13e-02 5738 4 4 1.000 0.001 TF:M02067_0 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 0 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 4.15e-02 134 4 1 0.250 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q9UK61 306 4.18e-02 135 4 1 0.250 0.007 TF:M05362_0 tf 1 Factor: NKX1-1; motif: WTAATAWGGA; match class: 0 1 Q9UK61 306 4.20e-02 2973 4 3 0.750 0.001 TF:M00427_0 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 0 1 Q9UK61,Q96LX8,Q99549 306 4.21e-02 136 4 1 0.250 0.007 TF:M05522_0 tf 1 Factor: ZNF341; motif: NTGGGGGGGGGG; match class: 0 1 Q99549 306 4.27e-02 2990 4 3 0.750 0.001 TF:M00042_1 tf 1 Factor: SOX5; motif: NNAACAATNN; match class: 1 1 Q5VWN6,Q9UK61,Q99549 306 4.33e-02 140 4 1 0.250 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q9UK61 306 4.35e-02 1153 4 2 0.500 0.002 TF:M01716_0 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 0 1 Q9UK61,Q99549 306 4.39e-02 1159 4 2 0.500 0.002 TF:M01588_0 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 0 1 Q96LX8,Q99549 306 4.41e-02 3024 4 3 0.750 0.001 TF:M01231_0 tf 1 Factor: ZNF515; motif: GTGGGGGGTM; match class: 0 1 Q5VWN6,Q9UK61,Q99549 306 4.46e-02 5849 4 4 1.000 0.001 TF:M00644_1 tf 1 Factor: LBP-1; motif: CAGCTGS; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 4.54e-02 147 4 1 0.250 0.007 TF:M00203_1 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 1 1 Q96LX8 306 4.65e-02 578 4 2 0.500 0.003 MI:mmu-miR-466c-5p mi 1 MI:mmu-miR-466c-5p 1 Q5VWN6,Q96LX8 306 4.68e-02 1200 4 2 0.500 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q9UK61,Q99549 306 4.82e-02 589 4 2 0.500 0.003 MI:mmu-miR-466e-5p mi 1 MI:mmu-miR-466e-5p 1 Q5VWN6,Q96LX8 306 4.90e-02 594 4 2 0.500 0.003 MI:mmu-miR-466b-5p mi 1 MI:mmu-miR-466b-5p 1 Q5VWN6,Q96LX8 306 4.94e-02 6001 4 4 1.000 0.001 TF:M03582_1 tf 1 Factor: TWIST; motif: CACCTGG; match class: 1 1 Q5VWN6,Q9UK61,Q96LX8,Q99549 306 5.00e-02 4 4 1 0.250 0.250 CORUM:639 cor 1 RANBPM-Muskelin-TWA1-HSMpp8 complex 1 Q99549 306 5.00e-02 4 4 1 0.250 0.250 GO:0044030 BP 1 regulation of DNA methylation 1 Q99549 306 5.00e-02 600 4 2 0.500 0.003 MI:mmu-miR-466d-5p mi 1 MI:mmu-miR-466d-5p 1 Q5VWN6,Q96LX8 307 1.18e-03 5 3 1 0.333 0.200 TF:M05950_1 tf 1 Factor: ZNF700; motif: NSGWGTARTTCS; match class: 1 1 P51668 307 2.12e-03 9 3 1 0.333 0.111 TF:M06401_0 tf 1 Factor: ZNF551; motif: KGGTCCTAAATM; match class: 0 1 P51668 307 3.62e-03 1956 3 3 1.000 0.002 TF:M07235_0 tf 1 Factor: ZEB1; motif: NCWCACCTG; match class: 0 1 P51668,P14550,P25325 307 6.25e-03 1 3 1 0.333 1.000 GO:0047939 MF 1 L-glucuronate reductase activity 1 P14550 307 6.59e-03 28 3 1 0.333 0.036 TF:M06376_0 tf 1 Factor: ZNF770; motif: KGGGGGCRATS; match class: 0 1 P25325 307 1.03e-02 44 3 1 0.333 0.023 TF:M06392_0 tf 1 Factor: ZNF765; motif: NGGGCAARCATA; match class: 0 1 P25325 307 1.15e-02 2875 3 3 1.000 0.001 TF:M03788_0 tf 1 Factor: CAR_RXR; motif: CYNNNNTGAMCTYW; match class: 0 1 P51668,P14550,P25325 307 1.25e-02 2 3 1 0.333 0.500 GO:0009439 BP 1 cyanate metabolic process 1 P25325 307 1.25e-02 2 3 1 0.333 0.500 GO:0009440 BP 1 cyanate catabolic process 1 P25325 307 1.42e-02 163 3 2 0.667 0.012 GO:0044272 BP 1 sulfur compound biosynthetic process 1 P14550,P25325 307 1.55e-02 66 3 1 0.333 0.015 TF:M05866_0 tf 1 Factor: ZNF491; motif: KGGGGCAACAGW; match class: 0 1 P14550 307 1.61e-02 8 3 1 0.333 0.125 KEGG:04122 keg 1 Sulfur relay system 1 P25325 307 1.69e-02 72 3 1 0.333 0.014 TF:M06363_0 tf 1 Factor: ZNF730; motif: NNGGTGGACCGC; match class: 0 1 P14550 307 1.88e-02 3 3 1 0.333 0.333 GO:0004792 MF 1 thiosulfate sulfurtransferase activity 1 P25325 307 2.01e-02 10 3 1 0.333 0.100 KEGG:00920 keg 1 Sulfur metabolism 1 P25325 307 2.13e-02 91 3 1 0.333 0.011 TF:M01716_1 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 1 1 P25325 307 2.32e-02 1141 3 3 1.000 0.003 GO:0044248 BP 1 cellular catabolic process 1 P51668,P14550,P25325 307 2.46e-02 1191 3 2 0.667 0.002 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 P51668,P25325 307 2.50e-02 4 3 1 0.333 0.250 GO:0070814 BP 1 hydrogen sulfide biosynthetic process 1 P25325 307 2.73e-02 1256 3 2 0.667 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 P14550,P25325 307 2.83e-02 121 3 1 0.333 0.008 TF:M00005_0 tf 1 Factor: AP-4; motif: WGARYCAGCTGYGGNCNK; match class: 0 1 P25325 307 2.99e-02 1318 3 2 0.667 0.002 TF:M00693_0 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 0 1 P14550,P25325 307 3.06e-02 131 3 1 0.333 0.008 TF:M05419_0 tf 1 Factor: ZNF499; motif: NGTTCCGGASGC; match class: 0 1 P25325 307 3.13e-02 134 3 1 0.333 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 P51668 307 3.13e-02 5 3 1 0.333 0.200 GO:0019640 BP 1 glucuronate catabolic process to xylulose 5-phosphate 1 P14550 307 3.13e-02 5 3 1 0.333 0.200 GO:0051167 BP 1 xylulose 5-phosphate metabolic process 1 P14550 307 3.13e-02 5 3 1 0.333 0.200 GO:0006064 BP 1 glucuronate catabolic process 1 P14550 307 3.13e-02 5 3 1 0.333 0.200 GO:1901159 BP 1 xylulose 5-phosphate biosynthetic process 1 P14550 307 3.22e-02 138 3 1 0.333 0.007 TF:M00518_0 tf 1 Factor: PPARalpha:RXRalpha; motif: NNRGGTCATWGGGGTSANG; match class: 0 1 P25325 307 3.36e-02 1290 3 3 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 P51668,P14550,P25325 307 3.38e-02 145 3 1 0.333 0.007 TF:M02377_1 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 1 1 P25325 307 3.49e-02 150 3 1 0.333 0.007 TF:M04260_0 tf 1 Factor: FOXO3; motif: TTTCCCCACAC; match class: 0 1 P14550 307 3.75e-02 6 3 1 0.333 0.167 GO:0004032 MF 1 alditol:NADP+ 1-oxidoreductase activity 1 P14550 307 3.75e-02 6 3 1 0.333 0.167 GO:0070813 BP 1 hydrogen sulfide metabolic process 1 P25325 307 3.95e-02 1362 3 3 1.000 0.002 GO:0009056 BP 1 catabolic process 1 P51668,P14550,P25325 307 4.27e-02 184 3 1 0.333 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 P51668 307 4.38e-02 287 3 2 0.667 0.007 GO:0006790 BP 1 sulfur compound metabolic process 1 P14550,P25325 307 4.51e-02 1633 3 2 0.667 0.001 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 P51668,P25325 307 4.59e-02 4559 3 3 1.000 0.001 TF:M07409_0 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 0 1 P51668,P14550,P25325 307 4.65e-02 1658 3 2 0.667 0.001 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 P14550,P25325 307 4.72e-02 3902 3 3 1.000 0.001 HPA:039010_01 hpa 1 soft tissue 1; adipocytes[Uncertain,Low] 1 P51668,P14550,P25325 307 4.78e-02 206 3 1 0.333 0.005 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 P14550 307 4.83e-02 3931 3 3 1.000 0.001 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 P51668,P14550,P25325 307 4.90e-02 4658 3 3 1.000 0.001 TF:M04154_0 tf 1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 0 1 P51668,P14550,P25325 307 4.92e-02 4663 3 3 1.000 0.001 TF:M00155_0 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 0 1 P51668,P14550,P25325 307 5.00e-02 25 3 1 0.333 0.040 KEGG:00040 keg 1 Pentose and glucuronate interconversions 1 P14550 307 5.00e-02 5 3 1 0.333 0.200 REAC:5661270 rea 1 Catabolism of glucuronate to xylulose-5-phosphate 1 P14550 307 5.00e-02 8 3 1 0.333 0.125 GO:0016783 MF 1 sulfurtransferase activity 1 P25325 308 4.88e-05 20 2 2 1.000 0.100 REAC:2028269 rea 1 Signaling by Hippo 1 Q9Y2J4,P46937 308 3.82e-04 33 2 2 1.000 0.061 GO:0035329 BP 1 hippo signaling 1 Q9Y2J4,P46937 308 2.14e-02 9 2 1 0.500 0.111 TF:M05891_0 tf 1 Factor: VIK; motif: NGGGGCAGAATM; match class: 0 1 P46937 308 2.91e-02 29 2 1 0.500 0.034 HP:0000627 hp 1 Posterior embryotoxon 1 P46937 308 3.01e-02 30 2 1 0.500 0.033 HP:0008048 hp 1 Abnormality of the line of Schwalbe 1 P46937 308 4.45e-02 24 2 1 0.500 0.042 REAC:2032785 rea 1 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1 P46937 308 4.52e-02 19 2 1 0.500 0.053 TF:M05720_0 tf 1 Factor: ZNF134; motif: NGAAGACGGGGTCGGCNN; match class: 0 1 P46937 308 5.00e-02 21 2 1 0.500 0.048 TF:M05827_0 tf 1 Factor: ZNF544; motif: NGGTAAAGGANA; match class: 0 1 Q9Y2J4 308 5.00e-02 1 2 1 0.500 1.000 OMIM:120433 omi 1 COLOBOMA, OCULAR, WITH OR WITHOUT HEARING IMPAIRMENT, CLEFT LIP/PALATE,AND/OR MENTAL RETARDATION; COB1 1 P46937 308 5.00e-02 27 2 1 0.500 0.037 KEGG:04392 keg 1 Hippo signaling pathway -multiple species 1 P46937 308 5.00e-02 27 2 1 0.500 0.037 REAC:1251985 rea 1 Nuclear signaling by ERBB4 1 P46937 308 5.00e-02 8 2 1 0.500 0.125 CORUM:848 cor 1 RICH1/AMOT polarity complex, Flag-Amot precipitated 1 Q9Y2J4 308 5.00e-02 6 2 1 0.500 0.167 GO:0060242 BP 1 contact inhibition 1 P46937 308 5.00e-02 21 2 1 0.500 0.048 TF:M03978_0 tf 1 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN; match class: 0 1 P46937 308 5.00e-02 50 2 1 0.500 0.020 HP:0000567 hp 1 Chorioretinal coloboma 1 P46937 309 3.13e-03 1 2 1 0.500 1.000 GO:0060904 BP 1 regulation of protein folding in endoplasmic reticulum 1 P11021 309 6.25e-03 2 2 1 0.500 0.500 GO:1903891 BP 1 regulation of ATF6-mediated unfolded protein response 1 P11021 309 8.16e-03 6 2 1 0.500 0.167 CORUM:1226 cor 1 H2AX complex I 1 P11021 309 9.38e-03 3 2 1 0.500 0.333 GO:0090074 BP 1 negative regulation of protein homodimerization activity 1 P11021 309 9.38e-03 3 2 1 0.500 0.333 GO:0034663 CC 1 endoplasmic reticulum chaperone complex 1 P11021 309 1.09e-02 8 2 1 0.500 0.125 CORUM:1227 cor 1 H2AX complex II 1 P11021 309 1.21e-02 22 2 1 0.500 0.045 REAC:983170 rea 1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1 P11021 309 1.25e-02 4 2 1 0.500 0.250 GO:1903332 BP 1 regulation of protein folding 1 P11021 309 1.32e-02 24 2 1 0.500 0.042 REAC:381042 rea 1 PERK regulates gene expression 1 P11021 309 1.36e-02 10 2 1 0.500 0.100 CORUM:1223 cor 1 H2AX complex, isolated from cells without IR exposure 1 P11021 309 1.49e-02 11 2 1 0.500 0.091 CORUM:3082 cor 1 DGCR8 multiprotein complex 1 P11021 309 1.56e-02 5 2 1 0.500 0.200 GO:1903897 BP 1 regulation of PERK-mediated unfolded protein response 1 P11021 309 1.57e-02 5 2 1 0.500 0.200 HP:0012048 hp 1 Oromandibular dystonia 1 Q9BYT9 309 1.75e-02 22 2 1 0.500 0.045 KEGG:05020 keg 1 Prion diseases 1 P11021 309 1.75e-02 22 2 1 0.500 0.045 KEGG:03060 keg 1 Protein export 1 P11021 309 1.88e-02 6 2 1 0.500 0.167 GO:0035437 BP 1 maintenance of protein localization in endoplasmic reticulum 1 P11021 309 2.44e-02 18 2 1 0.500 0.056 CORUM:1335 cor 1 SNW1 complex 1 P11021 309 2.50e-02 5 2 1 0.500 0.200 TF:M06160_1 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 1 1 P11021 309 2.50e-02 8 2 1 0.500 0.125 GO:1990440 BP 1 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1 P11021 309 2.50e-02 8 2 1 0.500 0.125 HP:0002346 hp 1 Head tremor 1 Q9BYT9 309 2.58e-02 19 2 1 0.500 0.053 CORUM:2721 cor 1 HCF-1 complex 1 P11021 309 2.81e-02 51 2 1 0.500 0.020 REAC:381070 rea 1 IRE1alpha activates chaperones 1 P11021 309 2.81e-02 9 2 1 0.500 0.111 GO:0036500 BP 1 ATF6-mediated unfolded protein response 1 P11021 309 2.81e-02 9 2 1 0.500 0.111 GO:0051787 MF 1 misfolded protein binding 1 P11021 309 3.13e-02 10 2 1 0.500 0.100 GO:1903894 BP 1 regulation of IRE1-mediated unfolded protein response 1 P11021 309 3.44e-02 11 2 1 0.500 0.091 GO:0005229 MF 1 intracellular calcium activated chloride channel activity 1 Q9BYT9 309 3.44e-02 11 2 1 0.500 0.091 GO:0061778 MF 1 intracellular chloride channel activity 1 Q9BYT9 309 3.58e-02 45 2 1 0.500 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P11021 309 3.75e-02 12 2 1 0.500 0.083 GO:0036499 BP 1 PERK-mediated unfolded protein response 1 P11021 309 3.75e-02 12 2 1 0.500 0.083 HP:0030188 hp 1 Tremor by anatomical site 1 Q9BYT9 309 4.06e-02 13 2 1 0.500 0.077 GO:0034975 BP 1 protein folding in endoplasmic reticulum 1 P11021 309 4.13e-02 75 2 1 0.500 0.013 REAC:3371453 rea 1 Regulation of HSF1-mediated heat shock response 1 P11021 309 4.29e-02 78 2 1 0.500 0.013 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 P11021 309 4.38e-02 14 2 1 0.500 0.071 GO:0043496 BP 1 regulation of protein homodimerization activity 1 P11021 309 4.40e-02 80 2 1 0.500 0.013 REAC:2672351 rea 1 Stimuli-sensing channels 1 Q9BYT9 309 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 P11021 309 5.00e-02 37 2 1 0.500 0.027 CORUM:929 cor 1 CEN complex 1 P11021 309 5.00e-02 16 2 1 0.500 0.062 HP:0000643 hp 1 Blepharospasm 1 Q9BYT9 309 5.00e-02 10 2 1 0.500 0.100 TF:M05911_0 tf 1 Factor: ZNF300; motif: TCTTTAATCATG; match class: 0 1 Q9BYT9 309 5.00e-02 1 2 1 0.500 1.000 OMIM:615034 omi 1 DYSTONIA 24; DYT24 1 Q9BYT9 309 5.00e-02 10 2 1 0.500 0.100 TF:M04230_1 tf 1 Factor: FOXB1; motif: WATGTAAATATTGACAYW; match class: 1 1 Q9BYT9 309 5.00e-02 63 2 1 0.500 0.016 KEGG:04918 keg 1 Thyroid hormone synthesis 1 P11021 310 9.63e-03 21 2 1 0.500 0.048 TF:M07114_0 tf 1 Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN; match class: 0 1 Q15785 310 1.00e-02 1 2 1 0.500 1.000 GO:0004482 MF 1 mRNA (guanine-N7-)-methyltransferase activity 1 O43148 310 1.19e-02 26 2 1 0.500 0.038 TF:M00984_1 tf 1 Factor: PEBP; motif: GNTNACCACARANNK; match class: 1 1 O43148 310 2.43e-02 53 2 1 0.500 0.019 TF:M04003_0 tf 1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 0 1 Q15785 310 2.79e-02 61 2 1 0.500 0.016 TF:M06740_0 tf 1 Factor: ZNF492; motif: NTGTMWAGAAGA; match class: 0 1 O43148 310 2.79e-02 61 2 1 0.500 0.016 TF:M06022_0 tf 1 Factor: ZNF729; motif: NTGTMWAGAAGA; match class: 0 1 O43148 310 2.88e-02 1265 2 2 1.000 0.002 TF:M00423_0 tf 1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 0 1 Q15785,O43148 310 3.75e-02 1442 2 2 1.000 0.001 TF:M04470_0 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 0 1 Q15785,O43148 310 3.80e-02 1453 2 2 1.000 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 Q15785,O43148 310 4.21e-02 92 2 1 0.500 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 O43148 310 4.41e-02 1565 2 2 1.000 0.001 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 Q15785,O43148 310 4.43e-02 97 2 1 0.500 0.010 TF:M04005_0 tf 1 Factor: TCF7L1; motif: AAAGATCAAAGG; match class: 0 1 Q15785 310 4.52e-02 1584 2 2 1.000 0.001 TF:M00284_0 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 0 1 Q15785,O43148 310 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 Q15785,O43148 310 4.72e-02 453 2 2 1.000 0.004 MI:hsa-miR-300 mi 1 MI:hsa-miR-300 1 Q15785,O43148 310 4.94e-02 463 2 2 1.000 0.004 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 Q15785,O43148 310 5.00e-02 27 2 1 0.500 0.037 REAC:77075 rea 1 RNA Pol II CTD phosphorylation and interaction with CE 1 O43148 310 5.00e-02 1666 2 2 1.000 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q15785,O43148 310 5.00e-02 5 2 1 0.500 0.200 GO:0008174 MF 1 mRNA methyltransferase activity 1 O43148 310 5.00e-02 466 2 2 1.000 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 Q15785,O43148 310 5.00e-02 83 2 1 0.500 0.012 KEGG:03015 keg 1 mRNA surveillance pathway 1 O43148 311 1.54e-03 291 3 2 0.667 0.007 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 Q9H8M7,Q9UPN6 311 2.11e-03 341 3 2 0.667 0.006 TF:M06845_0 tf 1 Factor: ZBTB38; motif: NTYRATGCAMY; match class: 0 1 Q9H8M7,Q9UPN6 311 3.85e-03 1 3 1 0.333 1.000 GO:0071215 BP 1 cellular response to abscisic acid stimulus 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:0009787 BP 1 regulation of abscisic acid-activated signaling pathway 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:0009737 BP 1 response to abscisic acid 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:1901421 BP 1 positive regulation of response to alcohol 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:0009738 BP 1 abscisic acid-activated signaling pathway 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:0009789 BP 1 positive regulation of abscisic acid-activated signaling pathway 1 Q9NS86 311 3.85e-03 1 3 1 0.333 1.000 GO:1901419 BP 1 regulation of response to alcohol 1 Q9NS86 311 4.17e-03 481 3 2 0.667 0.004 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 Q9NS86,Q9H8M7 311 5.65e-03 561 3 2 0.667 0.004 TF:M03856_0 tf 1 Factor: Tbx5; motif: YMTYCTCWCACYTGN; match class: 0 1 Q9NS86,Q9UPN6 311 6.82e-03 29 3 1 0.333 0.034 TF:M06415_0 tf 1 Factor: ZNF429; motif: NMGTCGGGMCGC; match class: 0 1 Q9UPN6 311 1.05e-02 652 3 2 0.667 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q9H8M7,Q9UPN6 311 1.06e-02 773 3 2 0.667 0.003 TF:M07204_0 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 0 1 Q9NS86,Q9UPN6 311 1.08e-02 661 3 2 0.667 0.003 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 Q9NS86,Q9UPN6 311 1.10e-02 47 3 1 0.333 0.021 TF:M06484_0 tf 1 Factor: ZNF683; motif: TTCCYAAATGC; match class: 0 1 Q9NS86 311 1.11e-02 2837 3 3 1.000 0.001 TF:M04390_0 tf 1 Factor: LHX9; motif: NYAATTAN; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 1.11e-02 2837 3 3 1.000 0.001 TF:M04439_0 tf 1 Factor: SHOX2; motif: NYAATTAN; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 1.14e-02 2869 3 3 1.000 0.001 TF:M07055_0 tf 1 Factor: Pitx1; motif: CACTAATCCYYN; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 1.15e-02 3 3 1 0.333 0.333 GO:0016807 MF 1 cysteine-type carboxypeptidase activity 1 Q9H8M7 311 1.15e-02 3 3 1 0.333 0.333 GO:0070004 MF 1 cysteine-type exopeptidase activity 1 Q9H8M7 311 1.20e-02 51 3 1 0.333 0.020 TF:M00416_1 tf 1 Factor: Cart-1; motif: NNNTAATTNNCATTANCN; match class: 1 1 Q9H8M7 311 1.34e-02 57 3 1 0.333 0.018 TF:M01650_0 tf 1 Factor: PNR; motif: RAGRTCAAARRTCA; match class: 0 1 Q9NS86 311 1.55e-02 938 3 2 0.667 0.002 TF:M06308_0 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 0 1 Q9NS86,Q9H8M7 311 1.55e-02 940 3 2 0.667 0.002 TF:M06475_0 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 0 1 Q9NS86,Q9H8M7 311 1.58e-02 949 3 2 0.667 0.002 TF:M04071_1 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 1 1 Q9NS86,Q9H8M7 311 1.59e-02 68 3 1 0.333 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 Q9H8M7 311 1.68e-02 3258 3 3 1.000 0.001 TF:M03568_0 tf 1 Factor: TR4; motif: STGACCTTT; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 1.87e-02 80 3 1 0.333 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 Q9H8M7 311 2.01e-02 909 3 2 0.667 0.002 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 Q9H8M7,Q9UPN6 311 2.03e-02 1079 3 2 0.667 0.002 TF:M03884_0 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 0 1 Q9NS86,Q9UPN6 311 2.06e-02 88 3 1 0.333 0.011 TF:M07209_1 tf 1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 1 Q9H8M7 311 2.16e-02 945 3 2 0.667 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 Q9NS86,Q9UPN6 311 2.18e-02 93 3 1 0.333 0.011 TF:M00114_0 tf 1 Factor: Tax/CREB; motif: GGGGGTTGACGYANA; match class: 0 1 Q9NS86 311 2.69e-02 7 3 1 0.333 0.143 GO:0010314 MF 1 phosphatidylinositol-5-phosphate binding 1 Q9NS86 311 2.69e-02 7 3 1 0.333 0.143 GO:1990380 MF 1 Lys48-specific deubiquitinase activity 1 Q9H8M7 311 2.73e-02 3832 3 3 1.000 0.001 TF:M01035_1 tf 1 Factor: YY1; motif: NYNKCCATNTT; match class: 1 1 Q9NS86,Q9H8M7,Q9UPN6 311 2.84e-02 1282 3 2 0.667 0.002 TF:M00135_1 tf 1 Factor: Oct-1; motif: NNNNWTATGCAAATNTNNN; match class: 1 1 Q9NS86,Q9H8M7 311 2.93e-02 1303 3 2 0.667 0.002 TF:M04235_0 tf 1 Factor: FOXC2; motif: NGTMAATATTKACN; match class: 0 1 Q9H8M7,Q9UPN6 311 3.48e-02 3524 3 3 1.000 0.001 HPA:038010_02 hpa 1 smooth muscle; smooth muscle cells[Uncertain,Medium] 1 Q9NS86,Q9H8M7,Q9UPN6 311 3.63e-02 4215 3 3 1.000 0.001 TF:M02271_0 tf 1 Factor: HOXA5; motif: CDBWAATK; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 3.80e-02 1493 3 2 0.667 0.001 TF:M00349_1 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 1 1 Q9NS86,Q9H8M7 311 4.03e-02 147 3 1 0.333 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q9UPN6 311 4.07e-02 1547 3 2 0.667 0.001 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 Q9NS86,Q9H8M7 311 4.07e-02 1547 3 2 0.667 0.001 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 Q9NS86,Q9H8M7 311 4.14e-02 178 3 1 0.333 0.006 TF:M04234_1 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 1 1 Q9UPN6 311 4.28e-02 1589 3 2 0.667 0.001 TF:M01868_1 tf 1 Factor: CEBPepsilon; motif: HAANMTTKCNWMAC; match class: 1 1 Q9NS86,Q9H8M7 311 4.37e-02 188 3 1 0.333 0.005 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 Q9H8M7 311 4.37e-02 188 3 1 0.333 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q9H8M7 311 4.44e-02 191 3 1 0.333 0.005 TF:M07230_0 tf 1 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG; match class: 0 1 Q9H8M7 311 4.49e-02 4525 3 3 1.000 0.001 TF:M01778_0 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 0 1 Q9NS86,Q9H8M7,Q9UPN6 311 4.58e-02 1645 3 2 0.667 0.001 TF:M07420_0 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 0 1 Q9NS86,Q9UPN6 311 4.59e-02 4557 3 3 1.000 0.001 TF:M01836_1 tf 1 Factor: GR; motif: CNNNNTGTYCTNN; match class: 1 1 Q9NS86,Q9H8M7,Q9UPN6 311 4.59e-02 1648 3 2 0.667 0.001 TF:M00252_1 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 1 1 Q9H8M7,Q9UPN6 311 4.84e-02 1694 3 2 0.667 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 Q9NS86,Q9H8M7 311 4.94e-02 213 3 1 0.333 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 Q9H8M7 311 5.00e-02 1723 3 2 0.667 0.001 TF:M04234_0 tf 1 Factor: FOXC1; motif: WAWGTAAAYAW; match class: 0 1 Q9H8M7,Q9UPN6 311 5.00e-02 29 3 1 0.333 0.034 CORUM:1183 cor 1 CDC5L complex 1 Q9UPN6 311 5.00e-02 424 3 2 0.667 0.005 MI:mml-miR-000 mi 1 mml miRBase microRNAs 1 Q9NS86,Q9UPN6 311 5.00e-02 424 3 2 0.667 0.005 MI:mml-miR-189 mi 1 MI:mml-miR-189 1 Q9NS86,Q9UPN6 312 2.75e-05 19 3 2 0.667 0.105 REAC:2022870 rea 1 Chondroitin sulfate biosynthesis 1 P07585,Q86X52 312 7.58e-05 19 3 2 0.667 0.105 GO:0030206 BP 1 chondroitin sulfate biosynthetic process 1 P07585,Q86X52 312 1.02e-04 22 3 2 0.667 0.091 GO:0050650 BP 1 chondroitin sulfate proteoglycan biosynthetic process 1 P07585,Q86X52 312 1.33e-04 25 3 2 0.667 0.080 GO:0030204 BP 1 chondroitin sulfate metabolic process 1 P07585,Q86X52 312 1.52e-04 44 3 2 0.667 0.045 REAC:1793185 rea 1 Chondroitin sulfate/dermatan sulfate metabolism 1 P07585,Q86X52 312 1.55e-04 27 3 2 0.667 0.074 GO:0050654 BP 1 chondroitin sulfate proteoglycan metabolic process 1 P07585,Q86X52 312 3.81e-04 42 3 2 0.667 0.048 GO:0030166 BP 1 proteoglycan biosynthetic process 1 P07585,Q86X52 312 6.57e-04 55 3 2 0.667 0.036 GO:0006029 BP 1 proteoglycan metabolic process 1 P07585,Q86X52 312 7.90e-04 100 3 2 0.667 0.020 REAC:1630316 rea 1 Glycosaminoglycan metabolism 1 P07585,Q86X52 312 1.01e-03 68 3 2 0.667 0.029 GO:1903510 BP 1 mucopolysaccharide metabolic process 1 P07585,Q86X52 312 1.50e-03 83 3 2 0.667 0.024 GO:0006023 BP 1 aminoglycan biosynthetic process 1 P07585,Q86X52 312 1.50e-03 83 3 2 0.667 0.024 GO:0006024 BP 1 glycosaminoglycan biosynthetic process 1 P07585,Q86X52 312 2.41e-03 105 3 2 0.667 0.019 GO:0030203 BP 1 glycosaminoglycan metabolic process 1 P07585,Q86X52 312 2.69e-03 111 3 2 0.667 0.018 GO:0006022 BP 1 aminoglycan metabolic process 1 P07585,Q86X52 312 3.49e-03 6 3 1 0.333 0.167 REAC:3595177 rea 1 Defective CHSY1 causes TPBS 1 P07585 312 3.49e-03 6 3 1 0.333 0.167 REAC:3595172 rea 1 Defective CHST3 causes SEDCJD 1 P07585 312 3.49e-03 6 3 1 0.333 0.167 REAC:3595174 rea 1 Defective CHST14 causes EDS, musculocontractural type 1 P07585 312 4.36e-03 433 3 2 0.667 0.005 MI:hsa-miR-299-3p mi 1 MI:hsa-miR-299-3p 1 P07585,Q6TDP4 312 4.74e-03 246 3 2 0.667 0.008 REAC:71387 rea 1 Metabolism of carbohydrates 1 P07585,Q86X52 312 5.80e-03 163 3 2 0.667 0.012 GO:0044272 BP 1 sulfur compound biosynthetic process 1 P07585,Q86X52 312 5.81e-03 10 3 1 0.333 0.100 REAC:2022923 rea 1 Dermatan sulfate biosynthesis 1 P07585 312 6.39e-03 11 3 1 0.333 0.091 REAC:2024101 rea 1 CS/DS degradation 1 P07585 312 7.67e-03 3 3 1 0.333 0.333 GO:0051901 BP 1 positive regulation of mitochondrial depolarization 1 P07585 312 7.67e-03 3 3 1 0.333 0.333 GO:1900747 BP 1 negative regulation of vascular endothelial growth factor signaling pathway 1 P07585 312 9.87e-03 17 3 1 0.333 0.059 REAC:3560801 rea 1 Defective B3GAT3 causes JDSSDHD 1 P07585 312 9.87e-03 17 3 1 0.333 0.059 REAC:3560783 rea 1 Defective B4GALT7 causes EDS, progeroid type 1 P07585 312 9.87e-03 17 3 1 0.333 0.059 REAC:4420332 rea 1 Defective B3GALT6 causes EDSP2 and SEMDJL1 1 P07585 312 1.02e-02 4 3 1 0.333 0.250 GO:0050510 MF 1 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity 1 Q86X52 312 1.02e-02 4 3 1 0.333 0.250 GO:1902548 BP 1 negative regulation of cellular response to vascular endothelial growth factor stimulus 1 P07585 312 1.08e-02 223 3 2 0.667 0.009 GO:0009101 BP 1 glycoprotein biosynthetic process 1 P07585,Q86X52 312 1.28e-02 22 3 1 0.333 0.045 REAC:3560782 rea 1 Diseases associated with glycosaminoglycan metabolism 1 P07585 312 1.28e-02 22 3 1 0.333 0.045 REAC:1971475 rea 1 A tetrasaccharide linker sequence is required for GAG synthesis 1 P07585 312 1.28e-02 5 3 1 0.333 0.200 GO:0047238 MF 1 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity 1 Q86X52 312 1.28e-02 5 3 1 0.333 0.200 GO:1904181 BP 1 positive regulation of membrane depolarization 1 P07585 312 1.32e-02 246 3 2 0.667 0.008 GO:0009100 BP 1 glycoprotein metabolic process 1 P07585,Q86X52 312 1.53e-02 6 3 1 0.333 0.167 GO:1900746 BP 1 regulation of vascular endothelial growth factor signaling pathway 1 P07585 312 1.79e-02 7 3 1 0.333 0.143 GO:0051900 BP 1 regulation of mitochondrial depolarization 1 P07585 312 1.79e-02 7 3 1 0.333 0.143 GO:0032839 CC 1 dendrite cytoplasm 1 Q6TDP4 312 1.79e-02 7 3 1 0.333 0.143 GO:1902547 BP 1 regulation of cellular response to vascular endothelial growth factor stimulus 1 P07585 312 1.79e-02 287 3 2 0.667 0.007 GO:0006790 BP 1 sulfur compound metabolic process 1 P07585,Q86X52 312 2.05e-02 8 3 1 0.333 0.125 GO:0032838 CC 1 cell projection cytoplasm 1 Q6TDP4 312 2.30e-02 9 3 1 0.333 0.111 GO:0051882 BP 1 mitochondrial depolarization 1 P07585 312 2.49e-02 43 3 1 0.333 0.023 REAC:3000178 rea 1 ECM proteoglycans 1 P07585 312 2.56e-02 10 3 1 0.333 0.100 GO:0030207 BP 1 chondroitin sulfate catabolic process 1 P07585 312 2.66e-02 46 3 1 0.333 0.022 REAC:1638091 rea 1 Heparan sulfate/heparin (HS-GAG) metabolism 1 P07585 312 2.81e-02 11 3 1 0.333 0.091 GO:0030208 BP 1 dermatan sulfate biosynthetic process 1 P07585 312 2.81e-02 11 3 1 0.333 0.091 GO:0030205 BP 1 dermatan sulfate metabolic process 1 P07585 312 3.07e-02 12 3 1 0.333 0.083 GO:0090141 BP 1 positive regulation of mitochondrial fission 1 P07585 312 3.29e-02 57 3 1 0.333 0.018 REAC:3781865 rea 1 Diseases of glycosylation 1 P07585 312 3.58e-02 14 3 1 0.333 0.071 GO:0050651 BP 1 dermatan sulfate proteoglycan biosynthetic process 1 P07585 312 3.58e-02 14 3 1 0.333 0.071 GO:0050655 BP 1 dermatan sulfate proteoglycan metabolic process 1 P07585 312 3.77e-02 418 3 2 0.667 0.005 GO:0051241 BP 1 negative regulation of multicellular organismal process 1 P07585,Q86X52 312 3.83e-02 15 3 1 0.333 0.067 GO:0038084 BP 1 vascular endothelial growth factor signaling pathway 1 P07585 312 3.83e-02 15 3 1 0.333 0.067 GO:0090140 BP 1 regulation of mitochondrial fission 1 P07585 312 4.68e-02 466 3 2 0.667 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P07585,Q86X52 312 4.85e-02 19 3 1 0.333 0.053 GO:0003254 BP 1 regulation of membrane depolarization 1 P07585 312 4.85e-02 19 3 1 0.333 0.053 GO:0008376 MF 1 acetylgalactosaminyltransferase activity 1 Q86X52 312 5.00e-02 20 3 1 0.333 0.050 KEGG:00532 keg 1 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1 Q86X52 312 5.00e-02 2 3 1 0.333 0.500 HP:0011487 hp 1 Increased corneal thickness 1 P07585 312 5.00e-02 87 3 1 0.333 0.011 REAC:1474228 rea 1 Degradation of the extracellular matrix 1 P07585 312 5.00e-02 482 3 2 0.667 0.004 GO:0044431 CC 1 Golgi apparatus part 1 P07585,Q86X52 312 5.00e-02 1 3 1 0.333 1.000 OMIM:610048 omi 1 CORNEAL DYSTROPHY, CONGENITAL STROMAL; CSCD;;CONGENITAL STROMAL CORNEAL DYSTROPHY 1 P07585 312 5.00e-02 2 3 1 0.333 0.500 HP:0011087 hp 1 Talon cusp 1 Q86X52 312 5.00e-02 2 3 1 0.333 0.500 HP:0008005 hp 1 Congenital corneal dystrophy 1 P07585 312 5.00e-02 113 3 2 0.667 0.018 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q86X52,Q6TDP4 312 5.00e-02 1 3 1 0.333 1.000 OMIM:605282 omi 1 TEMTAMY PREAXIAL BRACHYDACTYLY SYNDROME; TPBS;;PREAXIAL BRACHYDACTYLY SYNDROME, TEMTAMY TYPE 1 Q86X52 313 5.70e-03 353 4 2 0.500 0.006 MI:mmu-miR-709 mi 1 MI:mmu-miR-709 1 O95372,Q969T9 313 6.79e-03 386 4 2 0.500 0.005 MI:hsa-miR-940 mi 1 MI:hsa-miR-940 1 O95372,P17540 313 8.34e-03 1 4 1 0.250 1.000 GO:0071442 BP 1 positive regulation of histone H3-K14 acetylation 1 Q969T9 313 8.34e-03 1 4 1 0.250 1.000 GO:0047933 MF 1 glucose-1,6-bisphosphate synthase activity 1 Q6PCE3 313 8.84e-03 442 4 2 0.500 0.005 MI:hsa-miR-770-5p mi 1 MI:hsa-miR-770-5p 1 O95372,Q969T9 313 9.44e-03 457 4 2 0.500 0.004 MI:hsa-miR-634 mi 1 MI:hsa-miR-634 1 O95372,P17540 313 1.03e-02 479 4 2 0.500 0.004 MI:hsa-miR-369-5p mi 1 MI:hsa-miR-369-5p 1 O95372,P17540 313 1.06e-02 484 4 2 0.500 0.004 MI:hsa-let-7d mi 1 MI:hsa-let-7d 1 O95372,P17540 313 1.14e-02 504 4 2 0.500 0.004 MI:hsa-let-7a mi 1 MI:hsa-let-7a 1 O95372,P17540 313 1.32e-02 544 4 2 0.500 0.004 MI:hsa-miR-590-5p mi 1 MI:hsa-miR-590-5p 1 P17540,Q6PCE3 313 1.51e-02 1099 4 3 0.750 0.003 TF:M07339_0 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 0 1 O95372,P17540,Q969T9 313 1.74e-02 278 4 2 0.500 0.007 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 P17540,Q969T9 313 2.14e-02 309 4 2 0.500 0.006 TF:M00919_1 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 1 1 P17540,Q969T9 313 2.50e-02 3 4 1 0.250 0.333 GO:0071440 BP 1 regulation of histone H3-K14 acetylation 1 Q969T9 313 2.97e-02 365 4 2 0.500 0.005 TF:M00939_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 P17540,Q969T9 313 3.04e-02 26 4 1 0.250 0.038 KEGG:00500 keg 1 Starch and sucrose metabolism 1 Q6PCE3 313 3.33e-02 4 4 1 0.250 0.250 GO:0044154 BP 1 histone H3-K14 acetylation 1 Q969T9 313 3.33e-02 4 4 1 0.250 0.250 GO:0008474 MF 1 palmitoyl-(protein) hydrolase activity 1 O95372 313 3.33e-02 4 4 1 0.250 0.250 GO:0098734 BP 1 macromolecule depalmitoylation 1 O95372 313 3.33e-02 4 4 1 0.250 0.250 GO:0016775 MF 1 phosphotransferase activity, nitrogenous group as acceptor 1 P17540 313 3.33e-02 4 4 1 0.250 0.250 GO:0002084 BP 1 protein depalmitoylation 1 O95372 313 3.33e-02 4 4 1 0.250 0.250 GO:0004111 MF 1 creatine kinase activity 1 P17540 313 4.17e-02 5 4 1 0.250 0.200 GO:0098599 MF 1 palmitoyl hydrolase activity 1 O95372 313 4.25e-02 438 4 2 0.500 0.005 TF:M00427_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 P17540,Q969T9 313 4.52e-02 23 4 1 0.250 0.043 TF:M00987_1 tf 1 Factor: FOXP1; motif: TTATTTGTRTTKKYTWKTWT; match class: 1 1 Q969T9 313 4.67e-02 3739 4 4 1.000 0.001 TF:M00187_0 tf 1 Factor: USF; motif: GYCACGTGNC; match class: 0 1 O95372,P17540,Q969T9,Q6PCE3 313 5.00e-02 6 4 1 0.250 0.167 GO:0042159 BP 1 lipoprotein catabolic process 1 O95372 313 5.00e-02 43 4 1 0.250 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 P17540 313 5.00e-02 1658 4 3 0.750 0.002 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 O95372,P17540,Q969T9 313 5.00e-02 6 4 1 0.250 0.167 REAC:71288 rea 1 Creatine metabolism 1 P17540 314 1.67e-03 1 2 1 0.500 1.000 GO:1904902 BP 1 ESCRT III complex assembly 1 Q96FZ7 314 1.67e-03 1 2 1 0.500 1.000 GO:1904895 BP 1 ESCRT complex assembly 1 Q96FZ7 314 2.04e-03 13 2 1 0.500 0.077 TF:M06865_1 tf 1 Factor: PLAG1; motif: NTGGGGTGGGGG; match class: 1 1 Q96FZ7 314 3.17e-03 608 2 2 1.000 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.19e-03 824 2 2 1.000 0.002 TF:M01253_1 tf 1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 1 1 Q9UQB8,Q96FZ7 314 5.34e-03 34 2 1 0.500 0.029 TF:M06055_0 tf 1 Factor: ZNF99; motif: NGGKGAAGAYCA; match class: 0 1 Q96FZ7 314 5.46e-03 798 2 2 1.000 0.003 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 6.50e-03 871 2 2 1.000 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 7.15e-03 913 2 2 1.000 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 7.37e-03 47 2 1 0.500 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 Q9UQB8 314 7.85e-03 1128 2 2 1.000 0.002 TF:M07051_1 tf 1 Factor: NF-1B; motif: CTGGCASGV; match class: 1 1 Q9UQB8,Q96FZ7 314 7.87e-03 958 2 2 1.000 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 7.92e-03 1133 2 2 1.000 0.002 TF:M00514_0 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 0 1 Q9UQB8,Q96FZ7 314 8.00e-03 51 2 1 0.500 0.020 TF:M05772_0 tf 1 Factor: ZNF792; motif: NGGTCAAGCYGA; match class: 0 1 Q96FZ7 314 8.05e-03 969 2 2 1.000 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 9.14e-03 1217 2 2 1.000 0.002 TF:M07261_1 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 1 Q9UQB8,Q96FZ7 314 1.19e-02 1179 2 2 1.000 0.002 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.28e-02 1221 2 2 1.000 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.32e-02 1242 2 2 1.000 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.43e-02 1291 2 2 1.000 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.47e-02 1308 2 2 1.000 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.49e-02 1317 2 2 1.000 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.50e-02 9 2 1 0.500 0.111 GO:0051764 BP 1 actin crosslink formation 1 Q9UQB8 314 1.51e-02 1329 2 2 1.000 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.53e-02 1337 2 2 1.000 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.55e-02 1583 2 2 1.000 0.001 TF:M00002_0 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 0 1 Q9UQB8,Q96FZ7 314 1.61e-02 1372 2 2 1.000 0.001 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.64e-02 1632 2 2 1.000 0.001 TF:M03877_0 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 0 1 Q9UQB8,Q96FZ7 314 1.67e-02 10 2 1 0.500 0.100 GO:0000815 CC 1 ESCRT III complex 1 Q96FZ7 314 1.67e-02 1396 2 2 1.000 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q9UQB8 314 1.71e-02 109 2 1 0.500 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q9UQB8 314 1.73e-02 1419 2 2 1.000 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.74e-02 111 2 1 0.500 0.009 TF:M05462_0 tf 1 Factor: znf581; motif: NTGTGGGCAC; match class: 0 1 Q96FZ7 314 1.75e-02 1682 2 2 1.000 0.001 TF:M01778_1 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 1 1 Q9UQB8,Q96FZ7 314 1.77e-02 113 2 1 0.500 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q9UQB8 314 1.81e-02 1453 2 2 1.000 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.83e-02 1459 2 2 1.000 0.001 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.83e-02 504 2 2 1.000 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9UQB8,Q96FZ7 314 1.85e-02 1470 2 2 1.000 0.001 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 1.87e-02 1477 2 2 1.000 0.001 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.91e-02 1492 2 2 1.000 0.001 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 1.92e-02 1765 2 2 1.000 0.001 TF:M00280_1 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 1 1 Q9UQB8,Q96FZ7 314 1.98e-02 1521 2 2 1.000 0.001 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.00e-02 12 2 1 0.500 0.083 GO:0070064 MF 1 proline-rich region binding 1 Q9UQB8 314 2.12e-02 1574 2 2 1.000 0.001 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.15e-02 1583 2 2 1.000 0.001 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.17e-02 13 2 1 0.500 0.077 GO:2000251 BP 1 positive regulation of actin cytoskeleton reorganization 1 Q9UQB8 314 2.25e-02 1619 2 2 1.000 0.001 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.25e-02 1621 2 2 1.000 0.001 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.26e-02 1622 2 2 1.000 0.001 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.26e-02 1622 2 2 1.000 0.001 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.26e-02 1623 2 2 1.000 0.001 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.29e-02 1633 2 2 1.000 0.001 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q9UQB8,Q96FZ7 314 2.33e-02 14 2 1 0.500 0.071 GO:0008093 MF 1 cytoskeletal adaptor activity 1 Q9UQB8 314 2.39e-02 1670 2 2 1.000 0.001 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.45e-02 157 2 1 0.500 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q9UQB8 314 2.49e-02 1704 2 2 1.000 0.001 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q9UQB8 314 2.50e-02 1707 2 2 1.000 0.001 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.60e-02 141 2 1 0.500 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 Q9UQB8 314 2.64e-02 1756 2 2 1.000 0.001 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.67e-02 16 2 1 0.500 0.062 GO:1903541 BP 1 regulation of exosomal secretion 1 Q96FZ7 314 2.67e-02 171 2 1 0.500 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q9UQB8 314 2.67e-02 1765 2 2 1.000 0.001 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.68e-02 1769 2 2 1.000 0.001 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.72e-02 1780 2 2 1.000 0.001 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.72e-02 1782 2 2 1.000 0.001 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.74e-02 1787 2 2 1.000 0.001 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.74e-02 1788 2 2 1.000 0.001 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.77e-02 1797 2 2 1.000 0.001 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.78e-02 178 2 1 0.500 0.006 TF:M03839_1 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 1 1 Q9UQB8 314 2.79e-02 1803 2 2 1.000 0.001 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.83e-02 17 2 1 0.500 0.059 GO:0000920 BP 1 cell separation after cytokinesis 1 Q96FZ7 314 2.84e-02 1820 2 2 1.000 0.001 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.86e-02 1825 2 2 1.000 0.001 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 2.96e-02 1857 2 2 1.000 0.001 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 2.98e-02 1863 2 2 1.000 0.001 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.03e-02 1880 2 2 1.000 0.001 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.04e-02 1883 2 2 1.000 0.001 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.05e-02 1885 2 2 1.000 0.001 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.11e-02 1904 2 2 1.000 0.001 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.11e-02 2246 2 2 1.000 0.001 TF:M00037_1 tf 1 Factor: NF-E2; motif: TGCTGAGTCAY; match class: 1 1 Q9UQB8,Q96FZ7 314 3.13e-02 1909 2 2 1.000 0.001 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.17e-02 19 2 1 0.500 0.053 GO:1990182 BP 1 exosomal secretion 1 Q96FZ7 314 3.17e-02 19 2 1 0.500 0.053 GO:0097734 BP 1 extracellular exosome biogenesis 1 Q96FZ7 314 3.20e-02 1932 2 2 1.000 0.001 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.20e-02 1932 2 2 1.000 0.001 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.21e-02 1933 2 2 1.000 0.001 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.26e-02 1950 2 2 1.000 0.001 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.32e-02 213 2 1 0.500 0.005 TF:M04417_1 tf 1 Factor: NOTO; motif: NYTAATTANN; match class: 1 1 Q96FZ7 314 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.42e-02 1996 2 2 1.000 0.001 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.42e-02 1998 2 2 1.000 0.001 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 Q9UQB8,Q96FZ7 314 3.49e-02 2379 2 2 1.000 0.001 TF:M00800_1 tf 1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 1 Q9UQB8,Q96FZ7 314 3.51e-02 2024 2 2 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.52e-02 2026 2 2 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.54e-02 227 2 1 0.500 0.004 TF:M04169_1 tf 1 Factor: FIGLA; motif: NMCACCTGKN; match class: 1 1 Q96FZ7 314 3.57e-02 2039 2 2 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.58e-02 2043 2 2 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.60e-02 2049 2 2 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.61e-02 2051 2 2 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.62e-02 2055 2 2 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.64e-02 2060 2 2 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.67e-02 22 2 1 0.500 0.045 GO:0039702 BP 1 viral budding via host ESCRT complex 1 Q96FZ7 314 3.68e-02 2071 2 2 1.000 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.68e-02 2072 2 2 1.000 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 Q9UQB8,Q96FZ7 314 3.68e-02 2072 2 2 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.73e-02 2086 2 2 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.75e-02 2092 2 2 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.82e-02 2110 2 2 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.89e-02 2510 2 2 1.000 0.001 TF:M00691_0 tf 1 Factor: ATF1; motif: CYYTGACGTCA; match class: 0 1 Q9UQB8,Q96FZ7 314 3.89e-02 250 2 1 0.500 0.004 TF:M00464_0 tf 1 Factor: POU3F2; motif: TTATGYTAAT; match class: 0 1 Q96FZ7 314 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.92e-02 2139 2 2 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.92e-02 2139 2 2 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.94e-02 2527 2 2 1.000 0.001 TF:M02085_0 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 0 1 Q9UQB8,Q96FZ7 314 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 3.98e-02 2153 2 2 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 3.98e-02 2154 2 2 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.00e-02 2159 2 2 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.00e-02 24 2 1 0.500 0.042 GO:2000249 BP 1 regulation of actin cytoskeleton reorganization 1 Q9UQB8 314 4.01e-02 258 2 1 0.500 0.004 TF:M06576_0 tf 1 Factor: ZNF419; motif: GGGTGGCCGC; match class: 0 1 Q9UQB8 314 4.01e-02 258 2 1 0.500 0.004 TF:M06377_0 tf 1 Factor: ZNF773; motif: GGGTGGCCGC; match class: 0 1 Q9UQB8 314 4.03e-02 2168 2 2 1.000 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.09e-02 2183 2 2 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.11e-02 2188 2 2 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.12e-02 2191 2 2 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 Q9UQB8,Q96FZ7 314 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.17e-02 25 2 1 0.500 0.040 GO:1902590 BP 1 multi-organism organelle organization 1 Q96FZ7 314 4.17e-02 25 2 1 0.500 0.040 GO:0036452 CC 1 ESCRT complex 1 Q96FZ7 314 4.17e-02 25 2 1 0.500 0.040 GO:0046755 BP 1 viral budding 1 Q96FZ7 314 4.17e-02 25 2 1 0.500 0.040 GO:1902592 BP 1 multi-organism membrane budding 1 Q96FZ7 314 4.19e-02 2209 2 2 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.25e-02 2227 2 2 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q9UQB8,Q96FZ7 314 4.37e-02 281 2 1 0.500 0.004 TF:M03919_1 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 1 1 Q96FZ7 314 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.44e-02 2274 2 2 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.44e-02 2274 2 2 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.44e-02 2276 2 2 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.46e-02 2281 2 2 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.47e-02 288 2 1 0.500 0.003 TF:M07394_1 tf 1 Factor: slug; motif: CACCTGNNN; match class: 1 1 Q9UQB8 314 4.48e-02 2286 2 2 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.53e-02 375 2 2 1.000 0.005 MI:hsa-miR-492 mi 1 MI:hsa-miR-492 1 Q9UQB8,Q96FZ7 314 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.60e-02 296 2 1 0.500 0.003 TF:M00516_0 tf 1 Factor: E2F; motif: TTTSGCGCGMNR; match class: 0 1 Q96FZ7 314 4.61e-02 297 2 1 0.500 0.003 TF:M06747_0 tf 1 Factor: ZNF225; motif: KGRWGCWAANGM; match class: 0 1 Q9UQB8 314 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.71e-02 2342 2 2 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q9UQB8,Q96FZ7 314 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q9UQB8,Q96FZ7 314 4.95e-02 319 2 1 0.500 0.003 TF:M01830_0 tf 1 Factor: MAX; motif: CNNGMCACGTGN; match class: 0 1 Q96FZ7 314 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q96FZ7 314 5.00e-02 394 2 2 1.000 0.005 MI:hsa-miR-219-1-3p mi 1 MI:hsa-miR-219-1-3p 1 Q9UQB8,Q96FZ7 314 5.00e-02 70 2 1 0.500 0.014 KEGG:04520 keg 1 Adherens junction 1 Q9UQB8 314 5.00e-02 24 2 1 0.500 0.042 REAC:162588 rea 1 Budding and maturation of HIV virion 1 Q96FZ7 314 5.00e-02 10 2 1 0.500 0.100 CORUM:1186 cor 1 ESCRT-III complex 1 Q96FZ7 315 1.50e-14 19 5 5 1.000 0.263 GO:0003887 MF 1 DNA-directed DNA polymerase activity 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 7.45e-14 5 5 4 0.800 0.800 GO:0008622 CC 1 epsilon DNA polymerase complex 1 Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 8.50e-14 26 5 5 1.000 0.192 GO:0034061 MF 1 DNA polymerase activity 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 8.50e-14 26 5 5 1.000 0.192 GO:0043601 CC 1 nuclear replisome 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.04e-13 27 5 5 1.000 0.185 GO:0030894 CC 1 replisome 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 8.50e-13 40 5 5 1.000 0.125 GO:0043596 CC 1 nuclear replication fork 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 4.93e-12 56 5 5 1.000 0.089 GO:0005657 CC 1 replication fork 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 6.61e-12 8 5 4 0.800 0.500 REAC:68952 rea 1 DNA replication initiation 1 P09884,Q9NR33,Q9NRF9,Q07864 315 6.61e-12 8 5 4 0.800 0.500 REAC:174430 rea 1 Telomere C-strand synthesis initiation 1 P09884,Q9NR33,Q9NRF9,Q07864 315 1.49e-11 14 5 4 0.800 0.286 GO:0042575 CC 1 DNA polymerase complex 1 Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.49e-11 14 5 4 0.800 0.286 GO:0000109 CC 1 nucleotide-excision repair complex 1 Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.94e-11 73 5 5 1.000 0.068 GO:0032993 CC 1 protein-DNA complex 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.25e-10 105 5 5 1.000 0.048 GO:0016779 MF 1 nucleotidyltransferase activity 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 9.81e-10 37 5 4 0.800 0.108 GO:1990391 CC 1 DNA repair complex 1 Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.00e-09 24 5 4 0.800 0.167 REAC:174417 rea 1 Telomere C-strand (Lagging Strand) Synthesis 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.58e-09 30 5 4 0.800 0.133 REAC:180786 rea 1 Extension of Telomeres 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.96e-09 31 5 4 0.800 0.129 REAC:68962 rea 1 Activation of the pre-replicative complex 1 P09884,Q9NR33,Q9NRF9,Q07864 315 4.83e-09 216 5 5 1.000 0.023 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 9.71e-09 15 5 4 0.800 0.267 CORUM:1108 cor 1 DNA synthesome complex (15 subunits) 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.18e-08 18 5 4 0.800 0.222 CORUM:1111 cor 1 DNA synthesome complex (17 subunits) 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.18e-08 18 5 4 0.800 0.222 CORUM:1099 cor 1 DNA synthesome complex (17 subunits) 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.35e-08 51 5 4 0.800 0.078 REAC:157579 rea 1 Telomere Maintenance 1 P09884,Q9NR33,Q9NRF9,Q07864 315 6.07e-08 357 5 5 1.000 0.014 GO:0044454 CC 1 nuclear chromosome part 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 7.02e-08 36 5 4 0.800 0.111 KEGG:03030 keg 1 DNA replication 1 P09884,Q9NR33,Q9NRF9,Q07864 315 8.64e-08 383 5 5 1.000 0.013 GO:0000228 CC 1 nuclear chromosome 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.34e-07 78 5 4 0.800 0.051 REAC:73886 rea 1 Chromosome Maintenance 1 P09884,Q9NR33,Q9NRF9,Q07864 315 1.72e-07 83 5 4 0.800 0.048 REAC:68874 rea 1 M/G1 Transition 1 P09884,Q9NR33,Q9NRF9,Q07864 315 1.72e-07 83 5 4 0.800 0.048 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 P09884,Q9NR33,Q9NRF9,Q07864 315 3.52e-07 99 5 4 0.800 0.040 REAC:69239 rea 1 Synthesis of DNA 1 P09884,Q9NR33,Q9NRF9,Q07864 315 4.52e-07 21 5 3 0.600 0.143 REAC:5651801 rea 1 PCNA-Dependent Long Patch Base Excision Repair 1 Q9NR33,Q9NRF9,Q07864 315 4.64e-07 106 5 4 0.800 0.038 REAC:69306 rea 1 DNA Replication 1 P09884,Q9NR33,Q9NRF9,Q07864 315 6.09e-07 565 5 5 1.000 0.009 GO:0044427 CC 1 chromosomal part 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 6.45e-07 115 5 4 0.800 0.035 REAC:69206 rea 1 G1/S Transition 1 P09884,Q9NR33,Q9NRF9,Q07864 315 6.88e-07 24 5 3 0.600 0.125 REAC:110373 rea 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 Q9NR33,Q9NRF9,Q07864 315 6.88e-07 24 5 3 0.600 0.125 REAC:5696397 rea 1 Gap-filling DNA repair synthesis and ligation in GG-NER 1 Q9NR33,Q9NRF9,Q07864 315 8.87e-07 609 5 5 1.000 0.008 GO:0005694 CC 1 chromosome 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 9.33e-07 126 5 4 0.800 0.032 REAC:69242 rea 1 S Phase 1 P09884,Q9NR33,Q9NRF9,Q07864 315 1.00e-06 624 5 5 1.000 0.008 GO:1990234 CC 1 transferase complex 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.11e-06 28 5 3 0.600 0.107 REAC:110314 rea 1 Recognition of DNA damage by PCNA-containing replication complex 1 Q9NR33,Q9NRF9,Q07864 315 1.24e-06 29 5 3 0.600 0.103 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 Q9NR33,Q9NRF9,Q07864 315 1.35e-06 138 5 4 0.800 0.029 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.22e-06 35 5 3 0.600 0.086 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 Q9NR33,Q9NRF9,Q07864 315 2.22e-06 35 5 3 0.600 0.086 REAC:73884 rea 1 Base Excision Repair 1 Q9NR33,Q9NRF9,Q07864 315 2.42e-06 36 5 3 0.600 0.083 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 Q9NR33,Q9NRF9,Q07864 315 2.61e-06 755 5 5 1.000 0.007 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 3.35e-06 40 5 3 0.600 0.075 REAC:5696400 rea 1 Dual Incision in GG-NER 1 Q9NR33,Q9NRF9,Q07864 315 3.76e-06 95 5 4 0.800 0.042 KEGG:00240 keg 1 Pyrimidine metabolism 1 P09884,Q9NR33,Q9NRF9,Q07864 315 4.48e-06 44 5 3 0.600 0.068 REAC:73893 rea 1 DNA Damage Bypass 1 Q9NR33,Q9NRF9,Q07864 315 1.21e-05 61 5 3 0.600 0.049 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q9NR33,Q9NRF9,Q07864 315 1.25e-05 1033 5 5 1.000 0.005 GO:1902494 CC 1 catalytic complex 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.34e-05 63 5 3 0.600 0.048 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 Q9NR33,Q9NRF9,Q07864 315 1.35e-05 31 5 3 0.600 0.097 KEGG:03410 keg 1 Base excision repair 1 Q9NR33,Q9NRF9,Q07864 315 1.40e-05 64 5 3 0.600 0.047 REAC:6782135 rea 1 Dual incision in TC-NER 1 Q9NR33,Q9NRF9,Q07864 315 2.44e-05 151 5 4 0.800 0.026 KEGG:00230 keg 1 Purine metabolism 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.46e-05 77 5 3 0.600 0.039 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 Q9NR33,Q9NRF9,Q07864 315 3.00e-05 14 5 2 0.400 0.143 GO:0005671 CC 1 Ada2/Gcn5/Ada3 transcription activator complex 1 Q9NR33,Q9NRF9 315 3.08e-05 83 5 3 0.600 0.036 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 Q9NR33,Q9NRF9,Q07864 315 3.76e-05 4 5 2 0.400 0.500 CORUM:234 cor 1 HuCHRAC complex 1 Q9NRG0,Q9NRF9 315 4.25e-05 45 5 3 0.600 0.067 KEGG:03420 keg 1 Nucleotide excision repair 1 Q9NR33,Q9NRF9,Q07864 315 6.08e-05 104 5 3 0.600 0.029 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q9NR33,Q9NRF9,Q07864 315 7.01e-05 109 5 3 0.600 0.028 REAC:5696398 rea 1 Nucleotide Excision Repair 1 Q9NR33,Q9NRF9,Q07864 315 7.20e-05 110 5 3 0.600 0.027 REAC:5693538 rea 1 Homology Directed Repair 1 Q9NR33,Q9NRF9,Q07864 315 1.39e-04 137 5 3 0.600 0.022 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 Q9NR33,Q9NRF9,Q07864 315 1.40e-04 217 5 3 0.600 0.014 GO:0006260 BP 1 DNA replication 1 P09884,Q9NRF9,Q07864 315 1.43e-04 30 5 2 0.400 0.067 GO:0006270 BP 1 DNA replication initiation 1 P09884,Q07864 315 1.49e-04 448 5 4 0.800 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P09884,Q9NR33,Q9NRF9,Q07864 315 1.53e-04 31 5 2 0.400 0.065 GO:0000722 BP 1 telomere maintenance via recombination 1 P09884,Q07864 315 1.59e-04 1715 5 5 1.000 0.003 GO:0016740 MF 1 transferase activity 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 2.31e-04 38 5 2 0.400 0.053 GO:1902562 CC 1 H4 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 315 2.96e-04 43 5 2 0.400 0.047 GO:0006312 BP 1 mitotic recombination 1 P09884,Q07864 315 3.10e-04 1960 5 5 1.000 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 3.10e-04 1960 5 5 1.000 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 3.28e-04 547 5 4 0.800 0.007 REAC:1640170 rea 1 Cell Cycle 1 P09884,Q9NR33,Q9NRF9,Q07864 315 4.17e-04 51 5 2 0.400 0.039 GO:0043966 BP 1 histone H3 acetylation 1 Q9NR33,Q9NRF9 315 4.86e-04 13 5 2 0.400 0.154 CORUM:1004 cor 1 RC complex during S-phase of cell cycle 1 P09884,Q07864 315 4.86e-04 13 5 2 0.400 0.154 CORUM:1005 cor 1 RC complex during G2/M-phase of cell cycle 1 P09884,Q07864 315 7.22e-04 67 5 2 0.400 0.030 GO:0000731 BP 1 DNA synthesis involved in DNA repair 1 P09884,Q07864 315 1.06e-03 81 5 2 0.400 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 315 1.07e-03 272 5 3 0.600 0.011 REAC:73894 rea 1 DNA Repair 1 Q9NR33,Q9NRF9,Q07864 315 1.21e-03 449 5 3 0.600 0.007 GO:0006325 BP 1 chromatin organization 1 Q9NRG0,Q9NR33,Q9NRF9 315 1.33e-03 91 5 2 0.400 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q9NR33,Q9NRF9 315 1.33e-03 91 5 2 0.400 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q9NR33,Q9NRF9 315 1.70e-03 103 5 2 0.400 0.019 GO:0016573 BP 1 histone acetylation 1 Q9NR33,Q9NRF9 315 1.77e-03 105 5 2 0.400 0.019 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 315 1.84e-03 107 5 2 0.400 0.019 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 315 1.90e-03 2 5 1 0.200 0.500 GO:0006272 BP 1 leading strand elongation 1 P09884 315 1.90e-03 2 5 1 0.200 0.500 GO:0008623 CC 1 CHRAC 1 Q9NRG0 315 1.91e-03 109 5 2 0.400 0.018 GO:0000723 BP 1 telomere maintenance 1 P09884,Q07864 315 1.94e-03 110 5 2 0.400 0.018 GO:0032200 BP 1 telomere organization 1 P09884,Q07864 315 1.94e-03 110 5 2 0.400 0.018 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q9NR33,Q9NRF9 315 1.96e-03 1 5 1 0.200 1.000 OMIM:615083 omi 1 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12;;COLORECTAL CANCER, SUSCEPTIBILITY TO, ON CHROMOSOME 12q24 1 Q07864 315 1.96e-03 1 5 1 0.200 1.000 OMIM:615139 omi 1 FACIAL DYSMORPHISM, IMMUNODEFICIENCY, LIVEDO, AND SHORT STATURE; FILS 1 Q07864 315 1.96e-03 1 5 1 0.200 1.000 OMIM:310465 omi 1 N SYNDROME; NSX 1 P09884 315 2.27e-03 119 5 2 0.400 0.017 GO:0006261 BP 1 DNA-dependent DNA replication 1 P09884,Q07864 315 2.32e-03 2931 5 5 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 2.58e-03 127 5 2 0.400 0.016 GO:0006473 BP 1 protein acetylation 1 Q9NR33,Q9NRF9 315 2.85e-03 3 5 1 0.200 0.333 GO:0006287 BP 1 base-excision repair, gap-filling 1 Q07864 315 3.14e-03 140 5 2 0.400 0.014 GO:0071897 BP 1 DNA biosynthetic process 1 P09884,Q07864 315 3.42e-03 3168 5 5 1.000 0.002 GO:0044428 CC 1 nuclear part 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 3.50e-03 148 5 2 0.400 0.014 GO:0043543 BP 1 protein acylation 1 Q9NR33,Q9NRF9 315 3.81e-03 4 5 1 0.200 0.250 GO:0005658 CC 1 alpha DNA polymerase:primase complex 1 P09884 315 3.81e-03 4 5 1 0.200 0.250 GO:0003896 MF 1 DNA primase activity 1 P09884 315 3.92e-03 670 5 3 0.600 0.004 GO:0006259 BP 1 DNA metabolic process 1 P09884,Q9NRF9,Q07864 315 4.09e-03 160 5 2 0.400 0.013 GO:0006310 BP 1 DNA recombination 1 P09884,Q07864 315 4.84e-03 218 5 3 0.600 0.014 KEGG:05166 keg 1 HTLV-I infection 1 Q9NR33,Q9NRF9,Q07864 315 4.98e-03 3415 5 5 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 5.04e-03 178 5 2 0.400 0.011 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P09884,Q07864 315 5.44e-03 185 5 2 0.400 0.011 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P09884,Q07864 315 6.15e-03 3561 5 5 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 6.15e-03 3561 5 5 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 6.15e-03 3561 5 5 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 6.28e-03 199 5 2 0.400 0.010 GO:0060249 BP 1 anatomical structure homeostasis 1 P09884,Q07864 315 8.26e-03 332 5 2 0.400 0.006 MI:mmu-miR-719 mi 1 MI:mmu-miR-719 1 Q9NRG0,Q9NR33 315 9.08e-03 240 5 2 0.400 0.008 GO:0003682 MF 1 chromatin binding 1 P09884,Q07864 315 9.46e-03 3882 5 5 1.000 0.001 GO:0016043 BP 1 cellular component organization 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 9.50e-03 10 5 1 0.200 0.100 GO:0031010 CC 1 ISWI-type complex 1 Q9NRG0 315 9.89e-03 922 5 3 0.600 0.003 GO:0003677 MF 1 DNA binding 1 P09884,Q9NRG0,Q07864 315 1.02e-02 2096 5 4 0.800 0.002 GO:0043234 CC 1 protein complex 1 Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.03e-02 372 5 2 0.400 0.005 MI:hsa-miR-22* mi 1 MI:hsa-miR-22* 1 Q9NR33,Q9NRF9 315 1.05e-02 11 5 1 0.200 0.091 GO:0006273 BP 1 lagging strand elongation 1 P09884 315 1.12e-02 4013 5 5 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.13e-02 4019 5 5 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.24e-02 281 5 2 0.400 0.007 GO:0016570 BP 1 histone modification 1 Q9NR33,Q9NRF9 315 1.32e-02 290 5 2 0.400 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q9NR33,Q9NRF9 315 1.37e-02 296 5 2 0.400 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9NR33,Q9NRF9 315 1.44e-02 4 5 1 0.200 0.250 CORUM:1100 cor 1 DNA polymerase alpha-primase complex 1 P09884 315 1.62e-02 470 5 2 0.400 0.004 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 Q9NR33,Q9NRF9 315 1.83e-02 4430 5 5 1.000 0.001 GO:0005634 CC 1 nucleus 1 P09884,Q9NRG0,Q9NR33,Q9NRF9,Q07864 315 1.92e-02 13 5 1 0.200 0.077 REAC:113501 rea 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1 P09884 315 1.92e-02 515 5 2 0.400 0.004 MI:hsa-miR-424 mi 1 MI:hsa-miR-424 1 Q9NRG0,Q9NR33 315 2.07e-02 14 5 1 0.200 0.071 REAC:69091 rea 1 Polymerase switching 1 P09884 315 2.07e-02 14 5 1 0.200 0.071 REAC:69109 rea 1 Leading Strand Synthesis 1 P09884 315 2.07e-02 14 5 1 0.200 0.071 REAC:69166 rea 1 Removal of the Flap Intermediate 1 P09884 315 2.07e-02 14 5 1 0.200 0.071 REAC:174411 rea 1 Polymerase switching on the C-strand of the telomere 1 P09884 315 2.09e-02 22 5 1 0.200 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 P09884 315 2.09e-02 2529 5 4 0.800 0.002 GO:0005654 CC 1 nucleoplasm 1 P09884,Q9NR33,Q9NRF9,Q07864 315 2.18e-02 23 5 1 0.200 0.043 GO:0006297 BP 1 nucleotide-excision repair, DNA gap filling 1 Q07864 315 2.22e-02 15 5 1 0.200 0.067 REAC:69183 rea 1 Processive synthesis on the lagging strand 1 P09884 315 2.27e-02 384 5 2 0.400 0.005 GO:0006281 BP 1 DNA repair 1 P09884,Q07864 315 2.37e-02 25 5 1 0.200 0.040 GO:0006271 BP 1 DNA strand elongation involved in DNA replication 1 P09884 315 2.59e-02 411 5 2 0.400 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P09884,Q07864 315 2.66e-02 18 5 1 0.200 0.056 REAC:69205 rea 1 G1/S-Specific Transcription 1 P09884 315 2.76e-02 425 5 2 0.400 0.005 GO:0044770 BP 1 cell cycle phase transition 1 P09884,Q07864 315 2.95e-02 20 5 1 0.200 0.050 REAC:69186 rea 1 Lagging Strand Synthesis 1 P09884 315 3.03e-02 32 5 1 0.200 0.031 GO:0006284 BP 1 base-excision repair 1 Q07864 315 3.03e-02 32 5 1 0.200 0.031 GO:0022616 BP 1 DNA strand elongation 1 P09884 315 3.03e-02 446 5 2 0.400 0.004 GO:0051276 BP 1 chromosome organization 1 P09884,Q07864 315 3.23e-02 9 5 1 0.200 0.111 CORUM:1003 cor 1 RC complex (Replication competent complex) 1 P09884 315 3.58e-02 10 5 1 0.200 0.100 CORUM:1107 cor 1 DNA synthesome core complex 1 P09884 315 3.59e-02 38 5 1 0.200 0.026 GO:0003899 MF 1 DNA-directed 5'-3' RNA polymerase activity 1 P09884 315 3.78e-02 40 5 1 0.200 0.025 GO:0097747 MF 1 RNA polymerase activity 1 P09884 315 3.78e-02 40 5 1 0.200 0.025 GO:0034062 MF 1 5'-3' RNA polymerase activity 1 P09884 315 4.08e-02 521 5 2 0.400 0.004 GO:0044451 CC 1 nucleoplasm part 1 Q9NR33,Q9NRF9 315 4.34e-02 46 5 1 0.200 0.022 GO:0016363 CC 1 nuclear matrix 1 P09884 315 4.53e-02 48 5 1 0.200 0.021 GO:0006303 BP 1 double-strand break repair via nonhomologous end joining 1 P09884 315 4.71e-02 32 5 1 0.200 0.031 REAC:69190 rea 1 DNA strand elongation 1 P09884 315 4.82e-02 1614 5 3 0.600 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q9NRG0,Q9NR33,Q9NRF9 315 5.00e-02 1048 5 4 0.800 0.004 KEGG:01100 keg 1 Metabolic pathways 1 P09884,Q9NR33,Q9NRF9,Q07864 315 5.00e-02 14 5 1 0.200 0.071 CORUM:1098 cor 1 DNA synthesome complex (13 subunits) 1 P09884 315 5.00e-02 1 5 1 0.200 1.000 HP:0007421 hp 1 Telangiectases of the cheeks 1 Q07864 315 5.00e-02 53 5 1 0.200 0.019 GO:0000726 BP 1 non-recombinational repair 1 P09884 315 5.00e-02 34 5 1 0.200 0.029 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 P09884 316 2.96e-04 671 4 4 1.000 0.006 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 Q9NX65,Q53GI3,P10073,Q9H4T2 316 2.96e-04 671 4 4 1.000 0.006 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 Q9NX65,Q53GI3,P10073,Q9H4T2 316 6.94e-03 473 4 3 0.750 0.006 GO:0043565 MF 1 sequence-specific DNA binding 1 Q53GI3,P10073,Q9H4T2 316 7.21e-03 398 4 2 0.500 0.005 MI:hsa-miR-588 mi 1 MI:hsa-miR-588 1 Q53GI3,Q9H4T2 316 9.52e-03 459 4 2 0.500 0.004 MI:hsa-miR-299-5p mi 1 MI:hsa-miR-299-5p 1 Q9NX65,Q53GI3 316 4.08e-02 945 4 2 0.500 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P10073,Q9H4T2 316 5.00e-02 2 4 1 0.250 0.500 TF:M06603_1 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 1 1 Q9NX65 316 5.00e-02 922 4 3 0.750 0.003 GO:0003677 MF 1 DNA binding 1 Q53GI3,P10073,Q9H4T2 316 5.00e-02 628 4 2 0.500 0.003 REAC:212436 rea 1 Generic Transcription Pathway 1 Q9NX65,Q53GI3 317 2.10e-03 153 2 2 1.000 0.013 GO:0071103 BP 1 DNA conformation change 1 P41227,Q13472 317 4.17e-03 2 2 1 0.500 0.500 GO:1990190 MF 1 peptide-glutamate-N-acetyltransferase activity 1 P41227 317 4.17e-03 2 2 1 0.500 0.500 GO:0017198 BP 1 N-terminal peptidyl-serine acetylation 1 P41227 317 4.17e-03 2 2 1 0.500 0.500 GO:0018002 BP 1 N-terminal peptidyl-glutamic acid acetylation 1 P41227 317 4.17e-03 2 2 1 0.500 0.500 GO:0030920 BP 1 peptidyl-serine acetylation 1 P41227 317 4.17e-03 2 2 1 0.500 0.500 GO:1990189 MF 1 peptide-serine-N-acetyltransferase activity 1 P41227 317 6.26e-03 3 2 1 0.500 0.333 GO:0003917 MF 1 DNA topoisomerase type I activity 1 Q13472 317 1.00e-02 2 2 1 0.500 0.500 CORUM:2223 cor 1 BLM-TOP3A complex 1 Q13472 317 1.04e-02 5 2 1 0.500 0.200 GO:0031415 CC 1 NatA complex 1 P41227 317 1.19e-02 26 2 1 0.500 0.038 REAC:5693554 rea 1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1 Q13472 317 1.25e-02 6 2 1 0.500 0.167 GO:0003916 MF 1 DNA topoisomerase activity 1 Q13472 317 1.33e-02 29 2 1 0.500 0.034 REAC:5693568 rea 1 Resolution of D-loop Structures through Holliday Junction Intermediates 1 Q13472 317 1.37e-02 30 2 1 0.500 0.033 REAC:5693537 rea 1 Resolution of D-Loop Structures 1 Q13472 317 1.64e-02 36 2 1 0.500 0.028 REAC:5685938 rea 1 HDR through Single Strand Annealing (SSA) 1 Q13472 317 1.74e-02 38 2 1 0.500 0.026 REAC:5693616 rea 1 Presynaptic phase of homologous DNA pairing and strand exchange 1 Q13472 317 1.79e-02 446 2 2 1.000 0.004 GO:0051276 BP 1 chromosome organization 1 P41227,Q13472 317 1.87e-02 41 2 1 0.500 0.024 REAC:5693579 rea 1 Homologous DNA Pairing and Strand Exchange 1 Q13472 317 1.87e-02 41 2 1 0.500 0.024 REAC:912446 rea 1 Meiotic recombination 1 Q13472 317 1.88e-02 9 2 1 0.500 0.111 GO:0004596 MF 1 peptide alpha-N-acetyltransferase activity 1 P41227 317 1.88e-02 9 2 1 0.500 0.111 GO:0006265 BP 1 DNA topological change 1 Q13472 317 2.00e-02 2 2 1 0.500 0.500 HP:0011089 hp 1 Double tooth 1 P41227 317 2.00e-02 2 2 1 0.500 0.500 HP:0009762 hp 1 Facial wrinkling 1 P41227 317 2.00e-02 2 2 1 0.500 0.500 HP:0007733 hp 1 Laterally curved eyebrow 1 P41227 317 2.00e-02 2 2 1 0.500 0.500 HP:0011090 hp 1 Fused teeth 1 P41227 317 2.00e-02 2 2 1 0.500 0.500 HP:0020006 hp 1 Ciliary body coloboma 1 P41227 317 2.00e-02 4 2 1 0.500 0.250 CORUM:246 cor 1 BLM complex III 1 Q13472 317 2.08e-02 10 2 1 0.500 0.100 GO:0031414 CC 1 N-terminal protein acetyltransferase complex 1 P41227 317 2.78e-02 61 2 1 0.500 0.016 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 Q13472 317 2.92e-02 14 2 1 0.500 0.071 GO:0006474 BP 1 N-terminal protein amino acid acetylation 1 P41227 317 3.00e-02 3 2 1 0.500 0.333 HP:0100818 hp 1 Long thorax 1 P41227 317 3.00e-02 3 2 1 0.500 0.333 HP:0003717 hp 1 Minimal subcutaneous fat 1 P41227 317 3.00e-02 6 2 1 0.500 0.167 CORUM:2222 cor 1 BLM complex II 1 Q13472 317 3.00e-02 6 2 1 0.500 0.167 CORUM:2738 cor 1 BLM complex II 1 Q13472 317 3.10e-02 68 2 1 0.500 0.015 REAC:1500620 rea 1 Meiosis 1 Q13472 317 3.13e-02 333 2 2 1.000 0.006 TF:M06526_0 tf 1 Factor: ZNF555; motif: GAGCHGGCCC; match class: 0 1 P41227,Q13472 317 3.28e-02 72 2 1 0.500 0.014 REAC:69473 rea 1 G2/M DNA damage checkpoint 1 Q13472 317 3.37e-02 74 2 1 0.500 0.014 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 Q13472 317 3.63e-02 205 2 1 0.500 0.005 MI:hsa-miR-340* mi 1 MI:hsa-miR-340* 1 P41227 317 3.92e-02 86 2 1 0.500 0.012 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q13472 317 4.00e-02 4 2 1 0.500 0.250 HP:0200160 hp 1 Agenesis of maxillary incisor 1 P41227 317 4.00e-02 4 2 1 0.500 0.250 HP:0000667 hp 1 Phthisis bulbi 1 P41227 317 4.00e-02 4 2 1 0.500 0.250 HP:0200153 hp 1 Agenesis of lateral incisor 1 P41227 317 4.00e-02 4 2 1 0.500 0.250 HP:0000690 hp 1 Agenesis of maxillary lateral incisor 1 P41227 317 4.00e-02 8 2 1 0.500 0.125 CORUM:248 cor 1 BRAFT complex 1 Q13472 317 4.00e-02 8 2 1 0.500 0.125 CORUM:2739 cor 1 FA complex (Fanconi anemia complex) 1 Q13472 317 4.17e-02 20 2 1 0.500 0.050 GO:0018200 BP 1 peptidyl-glutamic acid modification 1 P41227 317 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-454* mi 1 MI:hsa-miR-454* 1 P41227 317 4.55e-02 258 2 1 0.500 0.004 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 P41227 317 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P41227,Q13472 317 4.73e-02 104 2 1 0.500 0.010 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q13472 317 5.00e-02 40 2 1 0.500 0.025 KEGG:03440 keg 1 Homologous recombination 1 Q13472 317 5.00e-02 110 2 1 0.500 0.009 REAC:5693538 rea 1 Homology Directed Repair 1 Q13472 317 5.00e-02 5 2 1 0.500 0.200 HP:0006485 hp 1 Agenesis of incisor 1 P41227 317 5.00e-02 421 2 2 1.000 0.005 TF:M00143_0 tf 1 Factor: Pax-5; motif: BCNNNRNGCANBGNTGNRTAGCSGCHNB; match class: 0 1 P41227,Q13472 317 5.00e-02 1 2 1 0.500 1.000 OMIM:309800 omi 1 MICROPHTHALMIA, SYNDROMIC 1; MCOPS1;;LENZ MICROPHTHALMIA SYNDROME;;LENZ DYSPLASIA;;MAA, FORMERLY 1 P41227 317 5.00e-02 5 2 1 0.500 0.200 HP:0006682 hp 1 Ventricular extrasystoles 1 P41227 317 5.00e-02 5 2 1 0.500 0.200 HP:0002000 hp 1 Short columella 1 P41227 317 5.00e-02 1 2 1 0.500 1.000 OMIM:300855 omi 1 OGDEN SYNDROME; OGDNS;;N-TERMINAL ACETYLTRANSFERASE DEFICIENCY; NATD 1 P41227 317 5.00e-02 24 2 1 0.500 0.042 GO:0031365 BP 1 N-terminal protein amino acid modification 1 P41227 317 5.00e-02 10 2 1 0.500 0.100 CORUM:244 cor 1 BRAFT complex 1 Q13472 318 3.57e-03 3 1 1 1.000 0.333 GO:0050567 MF 1 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity 1 O75879 318 3.57e-03 3 1 1 1.000 0.333 GO:0030956 CC 1 glutamyl-tRNA(Gln) amidotransferase complex 1 O75879 318 3.57e-03 3 1 1 1.000 0.333 GO:0070681 BP 1 glutaminyl-tRNAGln biosynthesis via transamidation 1 O75879 318 1.19e-02 10 1 1 1.000 0.100 GO:0016884 MF 1 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1 O75879 318 2.82e-02 259 1 1 1.000 0.004 MI:hsa-miR-191* mi 1 MI:hsa-miR-191* 1 O75879 318 3.02e-02 277 1 1 1.000 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 O75879 318 3.16e-02 290 1 1 1.000 0.003 MI:hsa-miR-132* mi 1 MI:hsa-miR-132* 1 O75879 318 3.32e-02 305 1 1 1.000 0.003 MI:hsa-miR-145* mi 1 MI:hsa-miR-145* 1 O75879 318 3.33e-02 306 1 1 1.000 0.003 MI:mmu-miR-681 mi 1 MI:mmu-miR-681 1 O75879 318 3.33e-02 360 1 1 1.000 0.003 HPA:021010_03 hpa 1 liver; bile duct cells[Uncertain,High] 1 O75879 318 3.40e-02 312 1 1 1.000 0.003 MI:mmu-miR-720 mi 1 MI:mmu-miR-720 1 O75879 318 3.47e-02 319 1 1 1.000 0.003 MI:hsa-miR-106b* mi 1 MI:hsa-miR-106b* 1 O75879 318 3.61e-02 331 1 1 1.000 0.003 MI:hsa-miR-580 mi 1 MI:hsa-miR-580 1 O75879 318 3.66e-02 336 1 1 1.000 0.003 MI:hsa-miR-193b* mi 1 MI:hsa-miR-193b* 1 O75879 318 3.68e-02 39 1 1 1.000 0.026 TF:M06178_0 tf 1 Factor: ZNF81; motif: NGTTCATGTACA; match class: 0 1 O75879 318 3.69e-02 339 1 1 1.000 0.003 MI:hsa-miR-26b* mi 1 MI:hsa-miR-26b* 1 O75879 318 3.79e-02 348 1 1 1.000 0.003 MI:hsa-miR-518f* mi 1 MI:hsa-miR-518f* 1 O75879 318 3.83e-02 352 1 1 1.000 0.003 MI:hsa-miR-127-3p mi 1 MI:hsa-miR-127-3p 1 O75879 318 3.89e-02 357 1 1 1.000 0.003 MI:hsa-miR-27a* mi 1 MI:hsa-miR-27a* 1 O75879 318 3.94e-02 362 1 1 1.000 0.003 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 O75879 318 3.95e-02 363 1 1 1.000 0.003 MI:mmu-miR-701 mi 1 MI:mmu-miR-701 1 O75879 318 3.97e-02 364 1 1 1.000 0.003 MI:hsa-miR-135a* mi 1 MI:hsa-miR-135a* 1 O75879 318 4.06e-02 373 1 1 1.000 0.003 MI:hsa-miR-412 mi 1 MI:hsa-miR-412 1 O75879 318 4.15e-02 381 1 1 1.000 0.003 MI:hsa-miR-609 mi 1 MI:hsa-miR-609 1 O75879 318 4.15e-02 44 1 1 1.000 0.023 TF:M00451_1 tf 1 Factor: Nkx3-1; motif: NWATAAGTATWT; match class: 1 1 O75879 318 4.16e-02 382 1 1 1.000 0.003 MI:mmu-miR-676 mi 1 MI:mmu-miR-676 1 O75879 318 4.16e-02 382 1 1 1.000 0.003 MI:hsa-miR-92b* mi 1 MI:hsa-miR-92b* 1 O75879 318 4.19e-02 385 1 1 1.000 0.003 MI:hsa-miR-635 mi 1 MI:hsa-miR-635 1 O75879 318 4.24e-02 389 1 1 1.000 0.003 MI:hsa-miR-92a-2* mi 1 MI:hsa-miR-92a-2* 1 O75879 318 4.28e-02 393 1 1 1.000 0.003 MI:hsa-miR-597 mi 1 MI:hsa-miR-597 1 O75879 318 4.30e-02 395 1 1 1.000 0.003 MI:hsa-miR-585 mi 1 MI:hsa-miR-585 1 O75879 318 4.32e-02 397 1 1 1.000 0.003 MI:mmu-miR-201 mi 1 MI:mmu-miR-201 1 O75879 318 4.36e-02 400 1 1 1.000 0.003 MI:hsa-miR-601 mi 1 MI:hsa-miR-601 1 O75879 318 4.42e-02 406 1 1 1.000 0.002 MI:mmu-miR-680 mi 1 MI:mmu-miR-680 1 O75879 318 4.55e-02 418 1 1 1.000 0.002 MI:hsa-miR-655 mi 1 MI:hsa-miR-655 1 O75879 318 4.55e-02 418 1 1 1.000 0.002 MI:gga-miR-460 mi 1 MI:gga-miR-460 1 O75879 318 4.58e-02 420 1 1 1.000 0.002 MI:hsa-miR-604 mi 1 MI:hsa-miR-604 1 O75879 318 4.59e-02 495 1 1 1.000 0.002 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 O75879 318 4.62e-02 424 1 1 1.000 0.002 MI:hsa-miR-138 mi 1 MI:hsa-miR-138 1 O75879 318 4.62e-02 424 1 1 1.000 0.002 MI:hsa-miR-555 mi 1 MI:hsa-miR-555 1 O75879 318 4.64e-02 426 1 1 1.000 0.002 MI:hsa-miR-381 mi 1 MI:hsa-miR-381 1 O75879 318 4.66e-02 428 1 1 1.000 0.002 MI:mmu-miR-666-3p mi 1 MI:mmu-miR-666-3p 1 O75879 318 4.71e-02 432 1 1 1.000 0.002 MI:hsa-miR-663 mi 1 MI:hsa-miR-663 1 O75879 318 4.74e-02 435 1 1 1.000 0.002 MI:hsa-miR-671-3p mi 1 MI:hsa-miR-671-3p 1 O75879 318 4.80e-02 441 1 1 1.000 0.002 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 O75879 318 4.80e-02 441 1 1 1.000 0.002 MI:hsa-miR-650 mi 1 MI:hsa-miR-650 1 O75879 318 4.80e-02 441 1 1 1.000 0.002 MI:hsa-miR-647 mi 1 MI:hsa-miR-647 1 O75879 318 4.80e-02 441 1 1 1.000 0.002 MI:hsa-miR-623 mi 1 MI:hsa-miR-623 1 O75879 318 4.83e-02 443 1 1 1.000 0.002 MI:hsa-miR-629 mi 1 MI:hsa-miR-629 1 O75879 318 4.88e-02 448 1 1 1.000 0.002 MI:hsa-miR-564 mi 1 MI:hsa-miR-564 1 O75879 318 4.89e-02 449 1 1 1.000 0.002 MI:hsa-miR-602 mi 1 MI:hsa-miR-602 1 O75879 318 4.90e-02 450 1 1 1.000 0.002 MI:hsa-miR-586 mi 1 MI:hsa-miR-586 1 O75879 318 4.93e-02 453 1 1 1.000 0.002 MI:hsa-miR-300 mi 1 MI:hsa-miR-300 1 O75879 318 5.00e-02 42 1 1 1.000 0.024 GO:0016879 MF 1 ligase activity, forming carbon-nitrogen bonds 1 O75879 318 5.00e-02 53 1 1 1.000 0.019 TF:M04003_0 tf 1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 0 1 O75879 318 5.00e-02 459 1 1 1.000 0.002 MI:hsa-miR-33b mi 1 MI:hsa-miR-33b 1 O75879 318 5.00e-02 459 1 1 1.000 0.002 MI:hsa-miR-608 mi 1 MI:hsa-miR-608 1 O75879 318 5.00e-02 44 1 1 1.000 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 O75879 319 9.08e-06 31 7 3 0.429 0.097 KEGG:00640 keg 1 Propanoate metabolism 1 Q9P2R7,P07864,Q9BYZ2 319 1.73e-05 46 7 3 0.429 0.065 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 Q9P2R7,P07864,Q9BYZ2 319 2.35e-05 4 7 2 0.286 0.500 GO:0004459 MF 1 L-lactate dehydrogenase activity 1 P07864,Q9BYZ2 319 2.35e-05 4 7 2 0.286 0.500 GO:0004457 MF 1 lactate dehydrogenase activity 1 P07864,Q9BYZ2 319 7.01e-05 73 7 3 0.429 0.041 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 P84085,P84077,P18085 319 8.56e-05 78 7 3 0.429 0.038 REAC:6811434 rea 1 COPI-dependent Golgi-to-ER retrograde traffic 1 P84085,P84077,P18085 319 2.21e-04 107 7 3 0.429 0.028 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 P84085,P84077,P18085 319 3.03e-04 119 7 3 0.429 0.025 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 P84085,P84077,P18085 319 5.12e-04 142 7 3 0.429 0.021 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 P84085,P84077,P18085 319 5.39e-04 26 7 2 0.286 0.077 REAC:70268 rea 1 Pyruvate metabolism 1 P07864,Q9BYZ2 319 6.38e-04 153 7 3 0.429 0.020 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 Q9P2R7,P07864,Q9BYZ2 319 8.86e-04 171 7 3 0.429 0.018 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 P84085,P84077,P18085 319 1.05e-03 158 7 3 0.429 0.019 GO:0003924 MF 1 GTPase activity 1 P84085,P84077,P18085 319 1.43e-03 38 7 2 0.286 0.053 KEGG:00620 keg 1 Pyruvate metabolism 1 P07864,Q9BYZ2 319 1.83e-03 43 7 2 0.286 0.047 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 P07864,Q9BYZ2 319 2.63e-03 248 7 3 0.429 0.012 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 P84085,P84077,P18085 319 2.80e-03 506 7 3 0.429 0.006 MI:hsa-miR-221 mi 1 MI:hsa-miR-221 1 P84077,P18085,Q9BYZ2 319 3.42e-03 2194 7 6 0.857 0.003 GO:0070062 CC 1 extracellular exosome 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 3.53e-03 2205 7 6 0.857 0.003 GO:0043230 CC 1 extracellular organelle 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 3.53e-03 2205 7 6 0.857 0.003 GO:1903561 CC 1 extracellular vesicle 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 3.78e-03 62 7 2 0.286 0.032 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P07864,Q9BYZ2 319 4.60e-03 1 7 1 0.143 1.000 OMIM:105150 omi 1 CEREBRAL AMYLOID ANGIOPATHY, CST3-RELATED;;AMYLOIDOSIS, CEREBROARTERIAL, ICELANDIC TYPE;;AMYLOIDOSIS VI;;HEREDITARY CEREBRAL HEMORRHAGE WITH AMYLOIDOSIS; HCHWA;;CEREBRAL HEMORRHAGE, HEREDITARY, WITH AMYLOIDOSIS 1 P01034 319 4.60e-03 1 7 1 0.143 1.000 OMIM:611953 omi 1 MACULAR DEGENERATION, AGE-RELATED, 11; ARMD11 1 P01034 319 4.60e-03 1 7 1 0.143 1.000 OMIM:612073 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH ORWITHOUT METHYLMALONIC ACIDURIA); MTDPS5;;MITOCHONDRIAL DNA DEPLETION SYNDROME, ENCEPHALOMYOPATHIC FORM, WITHOR WITHOUT METHYLMALONIC ACIDURIA, AUTOSOMAL RECESSIVE, SUCLA2-RELATED 1 Q9P2R7 319 5.60e-03 278 7 3 0.429 0.011 GO:0048193 BP 1 Golgi vesicle transport 1 P84085,P84077,P18085 319 7.53e-03 1 7 1 0.143 1.000 GO:0006781 BP 1 succinyl-CoA pathway 1 Q9P2R7 319 7.53e-03 1 7 1 0.143 1.000 GO:0060310 BP 1 regulation of elastin catabolic process 1 P01034 319 7.53e-03 1 7 1 0.143 1.000 GO:0010711 BP 1 negative regulation of collagen catabolic process 1 P01034 319 7.53e-03 1 7 1 0.143 1.000 GO:0060313 BP 1 negative regulation of blood vessel remodeling 1 P01034 319 7.53e-03 1 7 1 0.143 1.000 GO:0060311 BP 1 negative regulation of elastin catabolic process 1 P01034 319 7.53e-03 1 7 1 0.143 1.000 GO:0060309 BP 1 elastin catabolic process 1 P01034 319 7.69e-03 89 7 2 0.286 0.022 KEGG:04922 keg 1 Glucagon signaling pathway 1 P07864,Q9BYZ2 319 8.37e-03 2560 7 6 0.857 0.002 GO:0044710 BP 1 single-organism metabolic process 1 P01034,Q9P2R7,P84077,P07864,P18085,Q9BYZ2 319 9.71e-03 2627 7 6 0.857 0.002 GO:0044421 CC 1 extracellular region part 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 1.06e-02 75 7 2 0.286 0.027 GO:0006890 BP 1 retrograde vesicle-mediated transport, Golgi to ER 1 P84085,P18085 319 1.09e-02 76 7 2 0.286 0.026 GO:0006090 BP 1 pyruvate metabolic process 1 P07864,Q9BYZ2 319 1.14e-02 272 7 2 0.286 0.007 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 P84085,P01034 319 1.25e-02 2743 7 6 0.857 0.002 GO:0005576 CC 1 extracellular region 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 1.39e-02 2795 7 6 0.857 0.002 GO:0031982 CC 1 vesicle 1 P84085,P01034,Q9P2R7,P84077,P07864,P18085 319 1.51e-02 2 7 1 0.143 0.500 GO:0046502 BP 1 uroporphyrinogen III metabolic process 1 Q9P2R7 319 1.51e-02 2 7 1 0.143 0.500 GO:0044252 BP 1 negative regulation of multicellular organismal metabolic process 1 P01034 319 1.51e-02 2 7 1 0.143 0.500 GO:0010713 BP 1 negative regulation of collagen metabolic process 1 P01034 319 1.51e-02 2 7 1 0.143 0.500 GO:0006780 BP 1 uroporphyrinogen III biosynthetic process 1 Q9P2R7 319 1.51e-02 2 7 1 0.143 0.500 GO:0004775 MF 1 succinate-CoA ligase (ADP-forming) activity 1 Q9P2R7 319 1.53e-02 90 7 2 0.286 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P07864,Q9BYZ2 319 1.61e-02 8 7 1 0.143 0.125 REAC:167590 rea 1 Nef Mediated CD4 Down-regulation 1 P84077 319 1.63e-02 328 7 2 0.286 0.006 MI:hsa-miR-519e* mi 1 MI:hsa-miR-519e* 1 P01034,P07864 319 1.81e-02 98 7 2 0.286 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P07864,Q9BYZ2 319 1.96e-02 362 7 2 0.286 0.006 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 P01034,P07864 319 1.98e-02 363 7 2 0.286 0.006 MI:hsa-miR-150* mi 1 MI:hsa-miR-150* 1 P01034,P18085 319 2.16e-02 381 7 2 0.286 0.005 MI:hsa-miR-622 mi 1 MI:hsa-miR-622 1 P07864,P18085 319 2.20e-02 522 7 3 0.429 0.006 REAC:199991 rea 1 Membrane Trafficking 1 P84085,P84077,P18085 319 2.22e-02 386 7 2 0.286 0.005 MI:hsa-miR-940 mi 1 MI:hsa-miR-940 1 P84085,P01034 319 2.26e-02 3 7 1 0.143 0.333 GO:0010710 BP 1 regulation of collagen catabolic process 1 P01034 319 2.26e-02 3 7 1 0.143 0.333 GO:0004774 MF 1 succinate-CoA ligase activity 1 Q9P2R7 319 2.26e-02 3 7 1 0.143 0.333 GO:0051541 BP 1 elastin metabolic process 1 P01034 319 2.26e-02 3 7 1 0.143 0.333 GO:0060312 BP 1 regulation of blood vessel remodeling 1 P01034 319 2.26e-02 3 7 1 0.143 0.333 GO:0031584 BP 1 activation of phospholipase D activity 1 P18085 319 2.27e-02 391 7 2 0.286 0.005 MI:mmu-miR-678 mi 1 MI:mmu-miR-678 1 P18085,Q9BYZ2 319 2.28e-02 392 7 2 0.286 0.005 MI:hsa-miR-190 mi 1 MI:hsa-miR-190 1 Q9P2R7,P18085 319 2.45e-02 407 7 2 0.286 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 P84085,P01034 319 2.50e-02 1 7 1 0.143 1.000 HP:0007868 hp 1 Age-related macular degeneration 1 P01034 319 2.53e-02 549 7 3 0.429 0.005 REAC:5653656 rea 1 Vesicle-mediated transport 1 P84085,P84077,P18085 319 2.61e-02 421 7 2 0.286 0.005 MI:hsa-miR-30c-1* mi 1 MI:hsa-miR-30c-1* 1 P84085,Q9P2R7 319 2.65e-02 424 7 2 0.286 0.005 MI:hsa-miR-361-5p mi 1 MI:hsa-miR-361-5p 1 P18085,Q9BYZ2 319 2.71e-02 429 7 2 0.286 0.005 MI:hsa-miR-542-5p mi 1 MI:hsa-miR-542-5p 1 P84085,P84077 319 2.86e-02 442 7 2 0.286 0.005 MI:hsa-miR-182 mi 1 MI:hsa-miR-182 1 Q9P2R7,P18085 319 3.01e-02 4 7 1 0.143 0.250 GO:0010716 BP 1 negative regulation of extracellular matrix disassembly 1 P01034 319 3.01e-02 4 7 1 0.143 0.250 GO:0006104 BP 1 succinyl-CoA metabolic process 1 Q9P2R7 319 3.01e-02 4 7 1 0.143 0.250 GO:0034104 BP 1 negative regulation of tissue remodeling 1 P01034 319 3.01e-02 15 7 1 0.143 0.067 REAC:1660514 rea 1 Synthesis of PIPs at the Golgi membrane 1 P84077 319 3.04e-02 457 7 2 0.286 0.004 MI:hsa-miR-744 mi 1 MI:hsa-miR-744 1 P84085,P01034 319 3.04e-02 457 7 2 0.286 0.004 MI:hsa-miR-634 mi 1 MI:hsa-miR-634 1 P18085,Q9BYZ2 319 3.08e-02 460 7 2 0.286 0.004 MI:hsa-miR-302b mi 1 MI:hsa-miR-302b 1 P07864,Q9BYZ2 319 3.16e-02 466 7 2 0.286 0.004 MI:mmu-miR-666-5p mi 1 MI:mmu-miR-666-5p 1 P84085,P01034 319 3.21e-02 470 7 2 0.286 0.004 MI:hsa-miR-33a mi 1 MI:hsa-miR-33a 1 Q9P2R7,Q9BYZ2 319 3.28e-02 476 7 2 0.286 0.004 MI:hsa-miR-335 mi 1 MI:hsa-miR-335 1 Q9P2R7,P18085 319 3.30e-02 1169 7 4 0.571 0.003 REAC:392499 rea 1 Metabolism of proteins 1 P84085,P01034,P84077,P18085 319 3.36e-02 482 7 2 0.286 0.004 MI:hsa-miR-491-3p mi 1 MI:hsa-miR-491-3p 1 P84085,Q9BYZ2 319 3.61e-02 18 7 1 0.143 0.056 REAC:164938 rea 1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1 P84077 319 3.61e-02 18 7 1 0.143 0.056 REAC:71403 rea 1 Citric acid cycle (TCA cycle) 1 Q9P2R7 319 3.76e-02 5 7 1 0.143 0.200 GO:0060292 BP 1 long term synaptic depression 1 P84077 319 3.81e-02 19 7 1 0.143 0.053 REAC:5620916 rea 1 VxPx cargo-targeting to cilium 1 P18085 319 4.06e-02 534 7 2 0.286 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 P01034,Q9P2R7 319 4.06e-02 534 7 2 0.286 0.004 MI:hsa-miR-144 mi 1 MI:hsa-miR-144 1 Q9P2R7,Q9BYZ2 319 4.12e-02 553 7 3 0.429 0.005 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P84085,P84077,P18085 319 4.13e-02 539 7 2 0.286 0.004 MI:hsa-let-7g* mi 1 MI:hsa-let-7g* 1 P84085,P07864 319 4.51e-02 6 7 1 0.143 0.167 GO:1903054 BP 1 negative regulation of extracellular matrix organization 1 P01034 319 4.51e-02 6 7 1 0.143 0.167 GO:0016405 MF 1 CoA-ligase activity 1 Q9P2R7 319 4.67e-02 229 7 2 0.286 0.009 KEGG:04144 keg 1 Endocytosis 1 P84085,P84077 319 4.95e-02 590 7 3 0.429 0.005 GO:0016462 MF 1 pyrophosphatase activity 1 P84085,P84077,P18085 319 5.00e-02 2 7 1 0.143 0.500 CORUM:394 cor 1 Succinyl-CoA synthetase, ADP-forming 1 Q9P2R7 319 5.00e-02 2 7 1 0.143 0.500 HP:0008945 hp 1 Loss of ability to walk in early childhood 1 Q9P2R7 319 5.00e-02 821 7 4 0.571 0.005 TF:M02013_1 tf 1 Factor: HNF-1alpha; motif: RGTTAATNWTT; match class: 1 1 P01034,Q9P2R7,P07864,Q9BYZ2 319 5.00e-02 592 7 3 0.429 0.005 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P84085,P84077,P18085 319 5.00e-02 11 7 1 0.143 0.091 OMIM:603075 omi 1 Age-Related Macular Degeneration 1 P01034 319 5.00e-02 592 7 3 0.429 0.005 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P84085,P84077,P18085 319 5.00e-02 29 7 1 0.143 0.034 KEGG:00020 keg 1 Citrate cycle (TCA cycle) 1 Q9P2R7 319 5.00e-02 11 7 1 0.143 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 Q9P2R7 319 5.00e-02 25 7 1 0.143 0.040 REAC:164952 rea 1 The role of Nef in HIV-1 replication and disease pathogenesis 1 P84077 320 5.54e-04 2 2 1 0.500 0.500 REAC:110331 rea 1 Cleavage of the damaged purine 1 P29372 320 5.54e-04 2 2 1 0.500 0.500 REAC:73927 rea 1 Depurination 1 P29372 320 5.54e-04 2 2 1 0.500 0.500 REAC:110330 rea 1 Recognition and association of DNA glycosylase with site containing an affected purine 1 P29372 320 2.21e-03 8 2 1 0.500 0.125 REAC:73929 rea 1 Base-Excision Repair, AP Site Formation 1 P29372 320 2.21e-03 8 2 1 0.500 0.125 REAC:110357 rea 1 Displacement of DNA glycosylase by APEX1 1 P29372 320 2.78e-03 1 2 1 0.500 1.000 GO:0003905 MF 1 alkylbase DNA N-glycosylase activity 1 P29372 320 5.56e-03 2 2 1 0.500 0.500 GO:0045007 BP 1 depurination 1 P29372 320 9.66e-03 35 2 1 0.500 0.029 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 P29372 320 9.66e-03 35 2 1 0.500 0.029 REAC:73884 rea 1 Base Excision Repair 1 P29372 320 2.22e-02 8 2 1 0.500 0.125 GO:0006285 BP 1 base-excision repair, AP site formation 1 P29372 320 2.50e-02 9 2 1 0.500 0.111 GO:0006307 BP 1 DNA dealkylation involved in DNA repair 1 P29372 320 3.16e-02 24 2 1 0.500 0.042 TF:M04204_1 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 1 1 P29372 320 3.33e-02 12 2 1 0.500 0.083 GO:0019104 MF 1 DNA N-glycosylase activity 1 P29372 320 3.80e-02 857 2 2 1.000 0.002 TF:M00698_1 tf 1 Factor: HEB; motif: RCCWGCTG; match class: 1 1 P29372,Q9NVX7 320 3.89e-02 14 2 1 0.500 0.071 GO:0016799 MF 1 hydrolase activity, hydrolyzing N-glycosyl compounds 1 P29372 320 3.95e-02 30 2 1 0.500 0.033 TF:M04050_0 tf 1 Factor: NFAT5; motif: RTGGAAAATTACWN; match class: 0 1 P29372 320 4.57e-02 940 2 2 1.000 0.002 TF:M06475_0 tf 1 Factor: znf679; motif: CTTSAADAKC; match class: 0 1 P29372,Q9NVX7 320 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P29372,Q9NVX7 320 4.74e-02 36 2 1 0.500 0.028 TF:M04202_1 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 1 1 P29372 320 4.87e-02 37 2 1 0.500 0.027 TF:M05742_0 tf 1 Factor: ZNF57; motif: NSRAMGGGCAGG; match class: 0 1 P29372 320 5.00e-02 38 2 1 0.500 0.026 TF:M04201_1 tf 1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 1 1 P29372 320 5.00e-02 31 2 1 0.500 0.032 KEGG:03410 keg 1 Base excision repair 1 P29372 320 5.00e-02 18 2 1 0.500 0.056 GO:0035510 BP 1 DNA dealkylation 1 P29372 321 1.88e-03 8 3 1 0.333 0.125 TF:M05317_1 tf 1 Factor: sox30; motif: YAAATTTTCN; match class: 1 1 Q9BQG2 321 2.09e-03 1 3 1 0.333 1.000 GO:0019677 BP 1 NAD catabolic process 1 Q9BQG2 321 2.09e-03 1 3 1 0.333 1.000 GO:0019364 BP 1 pyridine nucleotide catabolic process 1 Q9BQG2 321 2.09e-03 1 3 1 0.333 1.000 GO:0035529 MF 1 NADH pyrophosphatase activity 1 Q9BQG2 321 2.09e-03 1 3 1 0.333 1.000 GO:0000210 MF 1 NAD+ diphosphatase activity 1 Q9BQG2 321 2.09e-03 1 3 1 0.333 1.000 GO:0006742 BP 1 NADP catabolic process 1 Q9BQG2 321 2.39e-03 363 3 2 0.667 0.006 TF:M01122_0 tf 1 Factor: ZNF219; motif: CRCCCCCCNCCC; match class: 0 1 Q8N653,Q9BQG2 321 4.03e-03 416 3 2 0.667 0.005 MI:hsa-miR-134 mi 1 MI:hsa-miR-134 1 Q8N653,Q13867 321 4.18e-03 1 3 1 0.333 1.000 OMIM:616564 omi 1 NOONAN SYNDROME 10; NS10 1 Q8N653 321 4.18e-03 1 3 1 0.333 1.000 OMIM:615670 omi 1 SCHWANNOMATOSIS 2; SWNTS2 1 Q8N653 321 4.24e-03 18 3 1 0.333 0.056 TF:M04215_0 tf 1 Factor: MAFF; motif: NTGCTGASTCAGCAW; match class: 0 1 Q13867 321 4.66e-03 509 3 2 0.667 0.004 TF:M00491_1 tf 1 Factor: MAZR; motif: NSGGGGGGGGMCN; match class: 1 1 Q8N653,Q9BQG2 321 5.65e-03 24 3 1 0.333 0.042 TF:M06458_0 tf 1 Factor: ZNF441; motif: NCCATTTTCAGW; match class: 0 1 Q9BQG2 321 6.26e-03 3 3 1 0.333 0.333 GO:0043418 BP 1 homocysteine catabolic process 1 Q13867 321 6.82e-03 29 3 1 0.333 0.034 TF:M06194_0 tf 1 Factor: ZNF121; motif: NGGTAADGMCGM; match class: 0 1 Q13867 321 8.27e-03 681 3 2 0.667 0.003 TF:M04427_0 tf 1 Factor: PHOX2B; motif: TAATYYAATTA; match class: 0 1 Q13867,Q9BQG2 321 8.70e-03 37 3 1 0.333 0.027 TF:M05742_0 tf 1 Factor: ZNF57; motif: NSRAMGGGCAGG; match class: 0 1 Q13867 321 1.04e-02 764 3 2 0.667 0.003 TF:M04308_0 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 0 1 Q13867,Q9BQG2 321 1.04e-02 5 3 1 0.333 0.200 GO:0072526 BP 1 pyridine-containing compound catabolic process 1 Q9BQG2 321 1.04e-02 5 3 1 0.333 0.200 GO:0006769 BP 1 nicotinamide metabolic process 1 Q9BQG2 321 1.22e-02 52 3 1 0.333 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 Q13867 321 1.25e-02 6 3 1 0.333 0.167 GO:0009109 BP 1 coenzyme catabolic process 1 Q9BQG2 321 1.25e-02 3 3 1 0.333 0.333 OMIM:162091 omi 1 Schwannomatosis 1 Q8N653 321 1.26e-02 266 3 2 0.667 0.008 GO:1901565 BP 1 organonitrogen compound catabolic process 1 Q13867,Q9BQG2 321 1.34e-02 4 3 1 0.333 0.250 HP:0006751 hp 1 Paraspinal neurofibromas 1 Q8N653 321 1.34e-02 4 3 1 0.333 0.250 HP:0009589 hp 1 Bilateral vestibular Schwannoma 1 Q8N653 321 1.34e-02 4 3 1 0.333 0.250 HP:0007576 hp 1 Palmar neurofibromas 1 Q8N653 321 1.50e-02 64 3 1 0.333 0.016 TF:M06002_0 tf 1 Factor: ZNF257; motif: NGGGWGGGCARM; match class: 0 1 Q13867 321 1.67e-02 8 3 1 0.333 0.125 GO:0009820 BP 1 alkaloid metabolic process 1 Q9BQG2 321 1.83e-02 1022 3 2 0.667 0.002 TF:M04426_0 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 0 1 Q13867,Q9BQG2 321 1.88e-02 9 3 1 0.333 0.111 GO:0050667 BP 1 homocysteine metabolic process 1 Q13867 321 1.95e-02 1055 3 2 0.667 0.002 TF:M00201_1 tf 1 Factor: C/EBP; motif: NGWVTKNKGYAAKNSAYA; match class: 1 1 Q13867,Q9BQG2 321 2.01e-02 6 3 1 0.333 0.167 HP:0010302 hp 1 Spinal cord tumor 1 Q8N653 321 2.01e-02 6 3 1 0.333 0.167 HP:0009737 hp 1 Lisch nodules 1 Q8N653 321 2.01e-02 6 3 1 0.333 0.167 HP:0009588 hp 1 Vestibular Schwannoma 1 Q8N653 321 2.01e-02 6 3 1 0.333 0.167 HP:0040096 hp 1 Neoplasm of the inner ear 1 Q8N653 321 2.01e-02 86 3 1 0.333 0.012 TF:M06108_0 tf 1 Factor: ZNF43; motif: NCTKGTTGGTGM; match class: 0 1 Q13867 321 2.01e-02 86 3 1 0.333 0.012 TF:M05464_1 tf 1 Factor: Sall1; motif: NAKKCGKAAAKG; match class: 1 1 Q13867 321 2.09e-02 10 3 1 0.333 0.100 GO:0000098 BP 1 sulfur amino acid catabolic process 1 Q13867 321 2.15e-02 1111 3 2 0.667 0.002 TF:M04282_0 tf 1 Factor: ARX; motif: NTAATYNAATTAN; match class: 0 1 Q13867,Q9BQG2 321 2.29e-02 98 3 1 0.333 0.010 TF:M04185_1 tf 1 Factor: OLIG1; motif: AMCATATGKT; match class: 1 1 Q9BQG2 321 2.29e-02 98 3 1 0.333 0.010 TF:M04185_0 tf 1 Factor: OLIG1; motif: AMCATATGKT; match class: 0 1 Q9BQG2 321 2.34e-02 7 3 1 0.333 0.143 HP:0100008 hp 1 Schwannoma 1 Q8N653 321 2.48e-02 106 3 1 0.333 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 Q13867 321 2.50e-02 5 3 1 0.333 0.200 REAC:197264 rea 1 Nicotinamide salvaging 1 Q9BQG2 321 2.50e-02 12 3 1 0.333 0.083 GO:0004551 MF 1 nucleotide diphosphatase activity 1 Q9BQG2 321 2.50e-02 12 3 1 0.333 0.083 GO:0051187 BP 1 cofactor catabolic process 1 Q9BQG2 321 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 Q8N653 321 2.71e-02 1251 3 2 0.667 0.002 TF:M07343_0 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 0 1 Q8N653,Q9BQG2 321 3.03e-02 130 3 1 0.333 0.008 TF:M06017_0 tf 1 Factor: ZNF586; motif: CCTGCMYGGTGM; match class: 0 1 Q8N653 321 3.03e-02 130 3 1 0.333 0.008 TF:M07328_0 tf 1 Factor: NF-AT5; motif: KGKRWTTTTCCAN; match class: 0 1 Q13867 321 3.19e-02 137 3 1 0.333 0.007 TF:M04339_1 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 1 1 Q13867 321 3.19e-02 137 3 1 0.333 0.007 TF:M04352_1 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 1 1 Q13867 321 3.22e-02 138 3 1 0.333 0.007 TF:M05994_0 tf 1 Factor: ZNF230; motif: NSNTAAAAACRA; match class: 0 1 Q13867 321 3.24e-02 139 3 1 0.333 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q13867 321 3.24e-02 139 3 1 0.333 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 Q9BQG2 321 3.33e-02 121 3 1 0.333 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 Q9BQG2 321 3.34e-02 10 3 1 0.333 0.100 HP:0012780 hp 1 Neoplasm of the ear 1 Q8N653 321 3.67e-02 11 3 1 0.333 0.091 HP:0001067 hp 1 Neurofibromas 1 Q8N653 321 3.67e-02 11 3 1 0.333 0.091 HP:0004859 hp 1 Amegakaryocytic thrombocytopenia 1 Q8N653 321 3.71e-02 1473 3 2 0.667 0.001 TF:M01142_0 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 0 1 Q8N653,Q9BQG2 321 3.84e-02 1500 3 2 0.667 0.001 TF:M01108_1 tf 1 Factor: HOXA7; motif: YCAATCT; match class: 1 1 Q13867,Q9BQG2 321 4.00e-02 12 3 1 0.333 0.083 HP:0008357 hp 1 Reduced factor XIII activity 1 Q8N653 321 4.00e-02 12 3 1 0.333 0.083 HP:0100697 hp 1 Neurofibrosarcoma 1 Q8N653 321 4.00e-02 12 3 1 0.333 0.083 HP:0011995 hp 1 Atrial septal aneurysm 1 Q8N653 321 4.00e-02 12 3 1 0.333 0.083 HP:0007429 hp 1 Few cafe-au-lait spots 1 Q8N653 321 4.00e-02 12 3 1 0.333 0.083 HP:0100769 hp 1 Synovitis 1 Q8N653 321 4.02e-02 1537 3 2 0.667 0.001 TF:M00491_0 tf 1 Factor: MAZR; motif: NSGGGGGGGGMCN; match class: 0 1 Q8N653,Q9BQG2 321 4.11e-02 177 3 1 0.333 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q9BQG2 321 4.27e-02 184 3 1 0.333 0.005 TF:M05417_0 tf 1 Factor: ZNF641; motif: NAGGGGKGGGGN; match class: 0 1 Q8N653 321 4.27e-02 184 3 1 0.333 0.005 TF:M05438_0 tf 1 Factor: Osx; motif: WGGGCGGGTS; match class: 0 1 Q8N653 321 4.34e-02 13 3 1 0.333 0.077 HP:0000917 hp 1 Superior pectus carinatum 1 Q8N653 321 4.34e-02 13 3 1 0.333 0.077 HP:0040180 hp 1 Hyperkeratosis pilaris 1 Q8N653 321 4.34e-02 13 3 1 0.333 0.077 HP:0004841 hp 1 Reduced factor XII activity 1 Q8N653 321 4.34e-02 13 3 1 0.333 0.077 HP:0000915 hp 1 Pectus excavatum of inferior sternum 1 Q8N653 321 4.39e-02 189 3 1 0.333 0.005 TF:M00053_1 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 1 1 Q8N653 321 4.51e-02 1633 3 2 0.667 0.001 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 Q8N653,Q9BQG2 321 4.59e-02 11 3 1 0.333 0.091 OMIM:163950 omi 1 Noonan Syndrome 1 Q8N653 321 4.67e-02 14 3 1 0.333 0.071 HP:0012209 hp 1 Juvenile myelomonocytic leukemia 1 Q8N653 321 4.69e-02 1666 3 2 0.667 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q13867,Q9BQG2 321 4.89e-02 1703 3 2 0.667 0.001 TF:M03835_0 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 0 1 Q13867,Q9BQG2 321 4.92e-02 1708 3 2 0.667 0.001 TF:M07264_0 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 0 1 Q13867,Q9BQG2 321 5.00e-02 10 3 1 0.333 0.100 REAC:196807 rea 1 Nicotinate metabolism 1 Q9BQG2 321 5.00e-02 12 3 1 0.333 0.083 OMIM:104300 omi 1 Alzheimer Disease 1 Q13867 321 5.00e-02 24 3 1 0.333 0.042 GO:0006739 BP 1 NADP metabolic process 1 Q9BQG2 321 5.00e-02 15 3 1 0.333 0.067 HP:0012324 hp 1 Myeloid leukemia 1 Q8N653 321 5.00e-02 15 3 1 0.333 0.067 HP:0001555 hp 1 Asymmetry of the thorax 1 Q8N653 321 5.00e-02 15 3 1 0.333 0.067 HP:0000914 hp 1 Shield chest 1 Q8N653 321 5.00e-02 22 3 1 0.333 0.045 KEGG:00760 keg 1 Nicotinate and nicotinamide metabolism 1 Q9BQG2 322 4.38e-02 7 2 1 0.500 0.143 TF:M06601_0 tf 1 Factor: ZNF501; motif: NGGTCAAGAATT; match class: 0 1 Q86YS6 322 5.00e-02 47 2 1 0.500 0.021 REAC:6811440 rea 1 Retrograde transport at the Trans-Golgi-Network 1 Q86YS6 322 5.00e-02 2 2 1 0.500 0.500 GO:0035526 BP 1 retrograde transport, plasma membrane to Golgi 1 Q86YS6 323 8.01e-04 2 2 1 0.500 0.500 REAC:3359475 rea 1 Defective MMAA causes methylmalonic aciduria type cblA 1 P22033 323 8.01e-04 2 2 1 0.500 0.500 REAC:3359478 rea 1 Defective MUT causes methylmalonic aciduria mut type 1 P22033 323 2.00e-03 5 2 1 0.500 0.200 REAC:71032 rea 1 Propionyl-CoA catabolism 1 P22033 323 2.11e-03 1 2 1 0.500 1.000 GO:0004494 MF 1 methylmalonyl-CoA mutase activity 1 P22033 323 2.11e-03 1 2 1 0.500 1.000 GO:0006436 BP 1 tryptophanyl-tRNA aminoacylation 1 P23381 323 3.60e-03 9 2 1 0.500 0.111 REAC:3296469 rea 1 Defects in cobalamin (B12) metabolism 1 P22033 323 4.23e-03 2 2 1 0.500 0.500 GO:0004830 MF 1 tryptophan-tRNA ligase activity 1 P23381 323 5.60e-03 14 2 1 0.500 0.071 REAC:196741 rea 1 Cobalamin (Cbl, vitamin B12) transport and metabolism 1 P22033 323 6.40e-03 16 2 1 0.500 0.062 REAC:3296482 rea 1 Defects in vitamin and cofactor metabolism 1 P22033 323 7.32e-03 283 2 2 1.000 0.007 GO:0006520 BP 1 cellular amino acid metabolic process 1 P23381,P22033 323 8.00e-03 20 2 1 0.500 0.050 REAC:77289 rea 1 Mitochondrial Fatty Acid Beta-Oxidation 1 P22033 323 9.59e-03 24 2 1 0.500 0.042 REAC:379716 rea 1 Cytosolic tRNA aminoacylation 1 P23381 323 1.27e-02 6 2 1 0.500 0.167 GO:0019626 BP 1 short-chain fatty acid catabolic process 1 P22033 323 1.27e-02 27 2 1 0.500 0.037 KEGG:00630 keg 1 Glyoxylate and dicarboxylate metabolism 1 P22033 323 1.36e-02 34 2 1 0.500 0.029 REAC:5668914 rea 1 Diseases of metabolism 1 P22033 323 1.46e-02 31 2 1 0.500 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P22033 323 1.68e-02 42 2 1 0.500 0.024 REAC:379724 rea 1 tRNA Aminoacylation 1 P23381 323 1.90e-02 9 2 1 0.500 0.111 GO:0050667 BP 1 homocysteine metabolic process 1 P22033 323 2.07e-02 44 2 1 0.500 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 P23381 323 2.11e-02 10 2 1 0.500 0.100 GO:0046459 BP 1 short-chain fatty acid metabolic process 1 P22033 323 2.16e-02 46 2 1 0.500 0.022 KEGG:00280 keg 1 Valine, leucine and isoleucine degradation 1 P22033 323 2.96e-02 14 2 1 0.500 0.071 GO:0009235 BP 1 cobalamin metabolic process 1 P22033 323 3.32e-02 17 2 1 0.500 0.059 TF:M05509_1 tf 1 Factor: ZAC; motif: KGGGGAAGAA; match class: 1 1 P23381 323 3.42e-02 86 2 1 0.500 0.012 REAC:196849 rea 1 Metabolism of water-soluble vitamins and cofactors 1 P22033 323 3.87e-02 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 P23381,P22033 323 4.10e-02 21 2 1 0.500 0.048 TF:M06139_0 tf 1 Factor: ZNF324; motif: NCTGGMATGGGM; match class: 0 1 P23381 323 4.10e-02 21 2 1 0.500 0.048 TF:M03978_0 tf 1 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN; match class: 0 1 P23381 323 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 P22033 323 4.43e-02 400 2 2 1.000 0.005 MI:hsa-miR-601 mi 1 MI:hsa-miR-601 1 P23381,P22033 323 4.65e-02 22 2 1 0.500 0.045 GO:0016866 MF 1 intramolecular transferase activity 1 P22033 323 4.87e-02 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 P23381,P22033 323 4.89e-02 799 2 2 1.000 0.003 TF:M00209_0 tf 1 Factor: NF-Y; motif: NCTGATTGGYTASY; match class: 0 1 P23381,P22033 323 5.00e-02 808 2 2 1.000 0.002 TF:M01796_0 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 0 1 P23381,P22033 323 5.00e-02 1 2 1 0.500 1.000 OMIM:251000 omi 1 METHYLMALONIC ACIDURIA DUE TO METHYLMALONYL-CoA MUTASE DEFICIENCY;;METHYLMALONIC ACIDEMIA DUE TO METHYLMALONYL-CoA MUTASE DEFICIENCYMMA DUE TO MCM DEFICIENCY;;METHYLMALONIC ACIDURIA, mut TYPEMETHYLMALONIC ACIDURIA, mut(0) TYPE, INCLUDED;;METHYLMALONIC ACIDURIA, mut(-) TYPE, INCLUDED 1 P22033 323 5.00e-02 2 2 1 0.500 0.500 HP:0005979 hp 1 Metabolic ketoacidosis 1 P22033 323 5.00e-02 2 2 1 0.500 0.500 HP:0002453 hp 1 Abnormality of the globus pallidus 1 P22033 323 5.00e-02 126 2 1 0.500 0.008 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P22033 323 5.00e-02 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 P23381,P22033 323 5.00e-02 107 2 1 0.500 0.009 KEGG:01200 keg 1 Carbon metabolism 1 P22033 324 1.68e-17 23 18 8 0.444 0.348 GO:0034451 CC 1 centriolar satellite 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96NB1,Q96RK4,Q4AC94,Q49A88 324 6.60e-17 409 18 14 0.778 0.034 GO:0005813 CC 1 centrosome 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 5.25e-16 474 18 14 0.778 0.030 GO:0005815 CC 1 microtubule organizing center 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 1.81e-13 114 18 9 0.500 0.079 GO:0044450 CC 1 microtubule organizing center part 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96NB1,Q96RK4,Q9C0D2,Q4AC94,Q49A88 324 4.48e-13 769 18 14 0.778 0.018 GO:0015630 CC 1 microtubule cytoskeleton 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 6.47e-12 933 18 14 0.778 0.015 GO:0044430 CC 1 cytoskeletal part 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 1.90e-10 17 18 5 0.278 0.294 GO:0071539 BP 1 protein localization to centrosome 1 Q15154,Q8WXW3,Q96RK4,Q4AC94,Q49A88 324 1.90e-10 17 18 5 0.278 0.294 GO:1905508 BP 1 protein localization to microtubule organizing center 1 Q15154,Q8WXW3,Q96RK4,Q4AC94,Q49A88 324 2.14e-10 1204 18 14 0.778 0.012 GO:0005856 CC 1 cytoskeleton 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 1.62e-09 25 18 5 0.278 0.200 GO:0072698 BP 1 protein localization to microtubule cytoskeleton 1 Q15154,Q8WXW3,Q96RK4,Q4AC94,Q49A88 324 2.09e-09 206 18 8 0.444 0.039 GO:0060271 BP 1 cilium assembly 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96NB1,Q96RK4,Q9C0D2,Q4AC94 324 2.45e-09 27 18 5 0.278 0.185 GO:0044380 BP 1 protein localization to cytoskeleton 1 Q15154,Q8WXW3,Q96RK4,Q4AC94,Q49A88 324 1.50e-07 21 18 4 0.222 0.190 GO:1905515 BP 1 non-motile cilium assembly 1 Q15154,Q8WXW3,Q96RK4,Q4AC94 324 1.53e-07 1960 18 14 0.778 0.007 GO:0043228 CC 1 non-membrane-bounded organelle 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 1.53e-07 1960 18 14 0.778 0.007 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q96NB1,Q96RK4,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 3.16e-07 142 18 6 0.333 0.042 GO:0044782 BP 1 cilium organization 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 1.83e-06 97 18 5 0.278 0.052 GO:0051297 BP 1 centrosome organization 1 O75665,Q15154,Q9Y2D8,Q96RK4,Q4AC94 324 2.85e-06 106 18 5 0.278 0.047 GO:0031023 BP 1 microtubule organizing center organization 1 O75665,Q15154,Q9Y2D8,Q96RK4,Q4AC94 324 6.72e-06 238 18 6 0.333 0.025 GO:0030031 BP 1 cell projection assembly 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 1.31e-05 267 18 6 0.333 0.022 GO:0005929 CC 1 cilium 1 O75665,Q15154,Q9Y2D8,Q96NB1,Q96RK4,Q9C0D2 324 1.44e-05 63 18 4 0.222 0.063 GO:0036064 CC 1 ciliary basal body 1 O75665,Q9Y2D8,Q96NB1,Q96RK4 324 1.64e-05 445 18 7 0.389 0.016 GO:0070925 BP 1 organelle assembly 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q9C0D2,Q4AC94 324 2.46e-05 72 18 4 0.222 0.056 GO:0005814 CC 1 centriole 1 O75665,Q96RK4,Q9C0D2,Q4AC94 324 4.47e-05 330 18 6 0.333 0.018 GO:0000226 BP 1 microtubule cytoskeleton organization 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 1.04e-04 220 18 5 0.278 0.023 GO:0044441 CC 1 ciliary part 1 O75665,Q15154,Q9Y2D8,Q96NB1,Q96RK4 324 1.41e-04 5 18 2 0.111 0.400 GO:0035735 BP 1 intraciliary transport involved in cilium assembly 1 Q15154,Q9Y2D8 324 2.11e-04 6 18 2 0.111 0.333 GO:0034454 BP 1 microtubule anchoring at centrosome 1 Q15154,Q96RK4 324 2.91e-04 459 18 6 0.333 0.013 GO:0007017 BP 1 microtubule-based process 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 3.94e-04 8 18 2 0.111 0.250 GO:0072393 BP 1 microtubule anchoring at microtubule organizing center 1 Q15154,Q96RK4 324 4.13e-04 52 18 3 0.167 0.058 GO:0031514 CC 1 motile cilium 1 Q96NB1,Q96RK4,Q9C0D2 324 7.46e-04 171 18 4 0.222 0.023 GO:0007018 BP 1 microtubule-based movement 1 O75665,Q15154,Q9Y2D8,Q96RK4 324 9.25e-04 12 18 2 0.111 0.167 GO:0043014 MF 1 alpha-tubulin binding 1 O75665,Q96RK4 324 1.27e-03 14 18 2 0.111 0.143 GO:0034453 BP 1 microtubule anchoring 1 Q15154,Q96RK4 324 1.27e-03 14 18 2 0.111 0.143 GO:0000242 CC 1 pericentriolar material 1 Q15154,Q96RK4 324 1.97e-03 409 18 5 0.278 0.012 GO:0044463 CC 1 cell projection part 1 O75665,Q15154,Q9Y2D8,Q96NB1,Q96RK4 324 1.99e-03 650 18 6 0.333 0.009 GO:0030030 BP 1 cell projection organization 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 2.92e-03 21 18 2 0.111 0.095 GO:0098840 BP 1 protein transport along microtubule 1 Q15154,Q9Y2D8 324 2.92e-03 21 18 2 0.111 0.095 GO:0099118 BP 1 microtubule-based protein transport 1 Q15154,Q9Y2D8 324 2.92e-03 21 18 2 0.111 0.095 GO:0042073 BP 1 intraciliary transport 1 Q15154,Q9Y2D8 324 3.66e-03 728 18 6 0.333 0.008 GO:0042995 CC 1 cell projection 1 O75665,Q15154,Q9Y2D8,Q96NB1,Q96RK4,Q9C0D2 324 4.54e-03 758 18 6 0.333 0.008 GO:0007010 BP 1 cytoskeleton organization 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 4.85e-03 27 18 2 0.111 0.074 GO:0007099 BP 1 centriole replication 1 O75665,Q4AC94 324 5.22e-03 28 18 2 0.111 0.071 GO:0098534 BP 1 centriole assembly 1 O75665,Q4AC94 324 5.66e-03 173 18 4 0.222 0.023 REAC:5617833 rea 1 Assembly of the primary cilium 1 O75665,Q15154,Q96RK4,Q4AC94 324 6.82e-03 32 18 2 0.111 0.062 GO:0035869 CC 1 ciliary transition zone 1 Q15154,Q96RK4 324 7.04e-03 1 18 1 0.056 1.000 OMIM:300804 omi 1 JOUBERT SYNDROME 10; JBTS10 1 O75665 324 7.04e-03 1 18 1 0.056 1.000 OMIM:300209 omi 1 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 2;;SGBS2 1 O75665 324 7.04e-03 1 18 1 0.056 1.000 OMIM:311200 omi 1 OROFACIODIGITAL SYNDROME I; OFD1;;ORAL-FACIAL-DIGITAL SYNDROME, TYPE I;;OFDS I;;PAPILLON-LEAGE AND PSAUME SYNDROME 1 O75665 324 7.04e-03 1 18 1 0.056 1.000 OMIM:300424 omi 1 RETINITIS PIGMENTOSA 23; RP23 1 O75665 324 7.04e-03 1 18 1 0.056 1.000 OMIM:615948 omi 1 OROFACIODIGITAL SYNDROME XIV; OFD14 1 Q4AC94 324 7.04e-03 1 18 1 0.056 1.000 OMIM:615636 omi 1 JOUBERT SYNDROME 21; JBTS21 1 Q1MSJ5 324 7.04e-03 1 18 1 0.056 1.000 OMIM:615092 omi 1 LEFT VENTRICULAR NONCOMPACTION 7; LVNC7 1 Q86YT6 324 7.04e-03 1 18 1 0.056 1.000 OMIM:615982 omi 1 BARDET-BIEDL SYNDROME 4; BBS4 1 Q96RK4 324 7.04e-03 1 18 1 0.056 1.000 OMIM:615860 omi 1 CONE-ROD DYSTROPHY 19; CORD19 1 Q6EMB2 324 7.26e-03 33 18 2 0.111 0.061 GO:0003341 BP 1 cilium movement 1 O75665,Q96RK4 324 7.65e-03 507 18 4 0.222 0.008 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 Q8WXW3,Q1MSJ5,Q96KV7,Q96M89 324 8.25e-03 20 18 2 0.111 0.100 OMIM:213300 omi 1 Joubert Syndrome 1 O75665,Q1MSJ5 324 9.59e-03 1 18 1 0.056 1.000 GO:0042505 BP 1 tyrosine phosphorylation of Stat6 protein 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0042525 BP 1 regulation of tyrosine phosphorylation of Stat6 protein 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0032815 BP 1 negative regulation of natural killer cell activation 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0010531 BP 1 activation of JAK1 kinase activity 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0005136 MF 1 interleukin-4 receptor binding 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0042521 BP 1 negative regulation of tyrosine phosphorylation of Stat4 protein 1 Q8WXW3 324 9.59e-03 1 18 1 0.056 1.000 GO:0042526 BP 1 positive regulation of tyrosine phosphorylation of Stat6 protein 1 Q8WXW3 324 9.62e-03 38 18 2 0.111 0.053 GO:1902117 BP 1 positive regulation of organelle assembly 1 Q96RK4,Q9C0D2 324 1.08e-02 92 18 3 0.167 0.033 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 O75665,Q15154,Q4AC94 324 1.12e-02 41 18 2 0.111 0.049 GO:0097730 CC 1 non-motile cilium 1 Q15154,Q96RK4 324 1.35e-02 45 18 2 0.111 0.044 GO:0007368 BP 1 determination of left/right symmetry 1 O75665,Q96RK4 324 1.49e-02 952 18 6 0.333 0.006 GO:0022402 BP 1 cell cycle process 1 O75665,Q15154,Q8WXW3,Q1MSJ5,Q96RK4,Q4AC94 324 1.53e-02 48 18 2 0.111 0.042 GO:0009855 BP 1 determination of bilateral symmetry 1 O75665,Q96RK4 324 1.53e-02 48 18 2 0.111 0.042 GO:0009799 BP 1 specification of symmetry 1 O75665,Q96RK4 324 1.59e-02 49 18 2 0.111 0.041 GO:0032465 BP 1 regulation of cytokinesis 1 Q1MSJ5,Q96RK4 324 1.67e-02 657 18 5 0.278 0.008 GO:0033365 BP 1 protein localization to organelle 1 Q15154,Q8WXW3,Q96RK4,Q4AC94,Q49A88 324 1.86e-02 53 18 2 0.111 0.038 GO:0090307 BP 1 mitotic spindle assembly 1 O75665,Q8WXW3 324 1.89e-02 361 18 3 0.167 0.008 MI:hsa-miR-374a mi 1 MI:hsa-miR-374a 1 Q1MSJ5,Q5T9S5,Q96NB1 324 1.92e-02 2 18 1 0.056 0.500 GO:0046548 BP 1 retinal rod cell development 1 Q96RK4 324 1.92e-02 2 18 1 0.056 0.500 GO:0031392 BP 1 regulation of prostaglandin biosynthetic process 1 Q8WXW3 324 1.92e-02 2 18 1 0.056 0.500 GO:0042504 BP 1 tyrosine phosphorylation of Stat4 protein 1 Q8WXW3 324 1.92e-02 2 18 1 0.056 0.500 GO:2001279 BP 1 regulation of unsaturated fatty acid biosynthetic process 1 Q8WXW3 324 1.92e-02 2 18 1 0.056 0.500 GO:0042519 BP 1 regulation of tyrosine phosphorylation of Stat4 protein 1 Q8WXW3 324 1.92e-02 2 18 1 0.056 0.500 GO:0031393 BP 1 negative regulation of prostaglandin biosynthetic process 1 Q8WXW3 324 1.93e-02 54 18 2 0.111 0.037 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 O75665,Q8WXW3 324 1.93e-02 54 18 2 0.111 0.037 GO:0051298 BP 1 centrosome duplication 1 O75665,Q4AC94 324 2.44e-02 210 18 3 0.167 0.014 GO:0007420 BP 1 brain development 1 Q15154,Q96RK4,Q49A88 324 2.53e-02 62 18 2 0.111 0.032 GO:0051302 BP 1 regulation of cell division 1 Q1MSJ5,Q96RK4 324 2.55e-02 7860 18 17 0.944 0.002 HPA:029020_01 hpa 1 placenta; trophoblastic cells[Uncertain,Low] 1 O75665,Q15154,Q8WXW3,Q86YT6,Q9Y6R9,Q9Y2D8,Q6EMB2,Q5T9S5,Q96NB1,Q96RK4,Q86T90,Q96DN5,Q96KV7,Q96M89,Q9C0D2,Q4AC94,Q49A88 324 2.61e-02 63 18 2 0.111 0.032 GO:0031503 BP 1 protein complex localization 1 Q15154,Q9Y2D8 324 2.74e-02 416 18 3 0.167 0.007 MI:hsa-miR-134 mi 1 MI:hsa-miR-134 1 O75665,Q6EMB2,Q96DN5 324 2.74e-02 219 18 3 0.167 0.014 GO:0060322 BP 1 head development 1 Q15154,Q96RK4,Q49A88 324 2.83e-02 421 18 3 0.167 0.007 MI:hsa-miR-603 mi 1 MI:hsa-miR-603 1 O75665,Q8WXW3,Q96RK4 324 2.83e-02 421 18 3 0.167 0.007 MI:hsa-miR-409-3p mi 1 MI:hsa-miR-409-3p 1 Q6EMB2,Q5T9S5,Q96DN5 324 2.87e-02 3 18 1 0.056 0.333 GO:0050893 BP 1 sensory processing 1 Q96RK4 324 2.87e-02 3 18 1 0.056 0.333 GO:0022027 BP 1 interkinetic nuclear migration 1 Q15154 324 2.87e-02 3 18 1 0.056 0.333 GO:0038108 BP 1 negative regulation of appetite by leptin-mediated signaling pathway 1 Q96RK4 324 2.94e-02 67 18 2 0.111 0.030 GO:0007098 BP 1 centrosome cycle 1 O75665,Q4AC94 324 3.25e-02 1111 18 6 0.333 0.005 GO:0034613 BP 1 cellular protein localization 1 Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94,Q49A88 324 3.40e-02 1121 18 6 0.333 0.005 GO:0070727 BP 1 cellular macromolecule localization 1 Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94,Q49A88 324 3.51e-02 1128 18 6 0.333 0.005 GO:0007049 BP 1 cell cycle 1 O75665,Q15154,Q8WXW3,Q1MSJ5,Q96RK4,Q4AC94 324 3.53e-02 459 18 3 0.167 0.007 MI:hsa-miR-33b mi 1 MI:hsa-miR-33b 1 Q15154,Q6EMB2,Q96KV7 324 3.71e-02 468 18 3 0.167 0.006 MI:hsa-miR-802 mi 1 MI:hsa-miR-802 1 Q1MSJ5,Q5T9S5,Q96RK4 324 3.75e-02 470 18 3 0.167 0.006 MI:hsa-miR-195 mi 1 MI:hsa-miR-195 1 Q6EMB2,Q5T9S5,Q96NB1 324 3.76e-02 76 18 2 0.111 0.026 GO:0051225 BP 1 spindle assembly 1 O75665,Q8WXW3 324 3.83e-02 4 18 1 0.056 0.250 GO:0032096 BP 1 negative regulation of response to food 1 Q96RK4 324 3.83e-02 4 18 1 0.056 0.250 GO:0032098 BP 1 regulation of appetite 1 Q96RK4 324 3.83e-02 4 18 1 0.056 0.250 GO:0032099 BP 1 negative regulation of appetite 1 Q96RK4 324 3.83e-02 4 18 1 0.056 0.250 GO:0042976 BP 1 activation of Janus kinase activity 1 Q8WXW3 324 3.83e-02 4 18 1 0.056 0.250 GO:1902019 BP 1 regulation of cilium-dependent cell motility 1 Q96RK4 324 3.83e-02 4 18 1 0.056 0.250 GO:0061511 BP 1 centriole elongation 1 Q4AC94 324 3.83e-02 4 18 1 0.056 0.250 GO:0060296 BP 1 regulation of cilium beat frequency involved in ciliary motility 1 Q96RK4 324 3.83e-02 4 18 1 0.056 0.250 GO:0060295 BP 1 regulation of cilium movement involved in cell motility 1 Q96RK4 324 3.83e-02 474 18 3 0.167 0.006 MI:hsa-miR-369-3p mi 1 MI:hsa-miR-369-3p 1 Q96RK4,Q96DN5,Q49A88 324 3.89e-02 3881 18 13 0.722 0.003 TF:M01127_0 tf 1 Factor: islet1; motif: GSNTAATRK; match class: 0 1 Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q5T9S5,Q96NB1,Q96RK4,Q86T90,Q96DN5,Q9C0D2,Q4AC94,Q49A88 324 4.16e-02 80 18 2 0.111 0.025 GO:0010970 BP 1 transport along microtubule 1 Q15154,Q9Y2D8 324 4.16e-02 80 18 2 0.111 0.025 GO:0099111 BP 1 microtubule-based transport 1 Q15154,Q9Y2D8 324 4.16e-02 1168 18 6 0.333 0.005 GO:1902589 BP 1 single-organism organelle organization 1 O75665,Q15154,Q8WXW3,Q9Y2D8,Q96RK4,Q4AC94 324 4.21e-02 205 18 2 0.111 0.010 MI:hsa-miR-340* mi 1 MI:hsa-miR-340* 1 Q6EMB2,Q96DN5 324 4.38e-02 500 18 3 0.167 0.006 MI:hsa-miR-524-5p mi 1 MI:hsa-miR-524-5p 1 O75665,Q6EMB2,Q96DN5 324 4.69e-02 103 18 3 0.167 0.029 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q15154,Q96RK4,Q96KV7 324 4.78e-02 5 18 1 0.056 0.200 GO:0032105 BP 1 negative regulation of response to extracellular stimulus 1 Q96RK4 324 4.78e-02 5 18 1 0.056 0.200 GO:0032108 BP 1 negative regulation of response to nutrient levels 1 Q96RK4 324 4.78e-02 5 18 1 0.056 0.200 GO:0032095 BP 1 regulation of response to food 1 Q96RK4 324 4.78e-02 5 18 1 0.056 0.200 GO:0021544 BP 1 subpallium development 1 Q96RK4 324 4.78e-02 5 18 1 0.056 0.200 GO:0021756 BP 1 striatum development 1 Q96RK4 324 4.89e-02 87 18 2 0.111 0.023 GO:0030900 BP 1 forebrain development 1 Q15154,Q96RK4 324 4.92e-02 524 18 3 0.167 0.006 MI:hsa-miR-30e mi 1 MI:hsa-miR-30e 1 Q8WXW3,Q5T9S5,Q96KV7 324 4.99e-02 527 18 3 0.167 0.006 MI:hsa-miR-337-5p mi 1 MI:hsa-miR-337-5p 1 Q8WXW3,Q5T9S5,Q96KV7 324 5.00e-02 88 18 2 0.111 0.023 GO:0007052 BP 1 mitotic spindle organization 1 O75665,Q8WXW3 324 5.00e-02 16 18 3 0.167 0.188 HP:0000180 hp 1 Lobulated tongue 1 O75665,Q1MSJ5,Q4AC94 324 5.00e-02 314 18 4 0.222 0.013 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 O75665,Q15154,Q96RK4,Q4AC94 324 5.00e-02 5351 18 15 0.833 0.003 TF:M01868_0 tf 1 Factor: CEBPepsilon; motif: HAANMTTKCNWMAC; match class: 0 1 O75665,Q15154,Q8WXW3,Q86YT6,Q1MSJ5,Q9Y6R9,Q9Y2D8,Q6EMB2,Q5T9S5,Q96NB1,Q96RK4,Q86T90,Q96M89,Q9C0D2,Q4AC94 325 5.21e-03 6 3 1 0.333 0.167 REAC:444257 rea 1 RSK activation 1 P51812 325 6.08e-03 7 3 1 0.333 0.143 REAC:199920 rea 1 CREB phosphorylation 1 P51812 325 6.67e-03 16 3 1 0.333 0.062 GO:0043555 BP 1 regulation of translation in response to stress 1 P51812 325 7.09e-03 17 3 1 0.333 0.059 GO:0043027 MF 1 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1 P51812 325 1.29e-02 31 3 1 0.333 0.032 GO:0043028 MF 1 cysteine-type endopeptidase regulator activity involved in apoptotic process 1 P51812 325 1.46e-02 35 3 1 0.333 0.029 GO:0004869 MF 1 cysteine-type endopeptidase inhibitor activity 1 P51812 325 1.82e-02 21 3 1 0.333 0.048 REAC:198753 rea 1 ERK/MAPK targets 1 P51812 325 1.91e-02 46 3 1 0.333 0.022 GO:0043154 BP 1 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 P51812 325 2.08e-02 24 3 1 0.333 0.042 REAC:198725 rea 1 Nuclear Events (kinase and transcription factor activation) 1 P51812 325 2.16e-02 52 3 1 0.333 0.019 GO:0043620 BP 1 regulation of DNA-templated transcription in response to stress 1 P51812 325 2.17e-02 25 3 1 0.333 0.040 REAC:442742 rea 1 CREB phosphorylation through the activation of Ras 1 P51812 325 2.33e-02 56 3 1 0.333 0.018 GO:2000117 BP 1 negative regulation of cysteine-type endopeptidase activity 1 P51812 325 2.42e-02 28 3 1 0.333 0.036 REAC:437239 rea 1 Recycling pathway of L1 1 P51812 325 2.60e-02 30 3 1 0.333 0.033 REAC:450282 rea 1 MAPK targets/ Nuclear events mediated by MAP kinases 1 P51812 325 2.85e-02 33 3 1 0.333 0.030 REAC:438064 rea 1 Post NMDA receptor activation events 1 P51812 325 2.95e-02 71 3 1 0.333 0.014 GO:0010951 BP 1 negative regulation of endopeptidase activity 1 P51812 325 3.15e-02 76 3 1 0.333 0.013 GO:0010466 BP 1 negative regulation of peptidase activity 1 P51812 325 3.20e-02 37 3 1 0.333 0.027 REAC:442755 rea 1 Activation of NMDA receptor upon glutamate binding and postsynaptic events 1 P51812 325 3.24e-02 78 3 1 0.333 0.013 GO:0030307 BP 1 positive regulation of cell growth 1 P51812 325 3.44e-02 83 3 1 0.333 0.012 GO:0002224 BP 1 toll-like receptor signaling pathway 1 P51812 325 3.46e-02 59 3 1 0.333 0.017 KEGG:04720 keg 1 Long-term potentiation 1 P51812 325 3.56e-02 86 3 1 0.333 0.012 GO:0004866 MF 1 endopeptidase inhibitor activity 1 P51812 325 3.65e-02 88 3 1 0.333 0.011 GO:0032496 BP 1 response to lipopolysaccharide 1 P51812 325 3.69e-02 89 3 1 0.333 0.011 GO:0030414 MF 1 peptidase inhibitor activity 1 P51812 325 3.77e-02 91 3 1 0.333 0.011 GO:0061135 MF 1 endopeptidase regulator activity 1 P51812 325 3.98e-02 96 3 1 0.333 0.010 GO:0002237 BP 1 response to molecule of bacterial origin 1 P51812 325 4.18e-02 101 3 1 0.333 0.010 GO:0045927 BP 1 positive regulation of growth 1 P51812 325 4.47e-02 108 3 1 0.333 0.009 GO:0002221 BP 1 pattern recognition receptor signaling pathway 1 P51812 325 4.55e-02 78 3 1 0.333 0.013 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 P51812 325 4.80e-02 116 3 1 0.333 0.009 GO:0061134 MF 1 peptidase regulator activity 1 P51812 325 4.91e-02 57 3 1 0.333 0.018 REAC:450294 rea 1 MAP kinase activation in TLR cascade 1 P51812 325 4.92e-02 119 3 1 0.333 0.008 GO:0045861 BP 1 negative regulation of proteolysis 1 P51812 325 5.00e-02 326 3 2 0.667 0.006 MI:hsa-miR-182* mi 1 MI:hsa-miR-182* 1 Q9UJ78,Q8IV31 325 5.00e-02 58 3 1 0.333 0.017 REAC:2559582 rea 1 Senescence-Associated Secretory Phenotype (SASP) 1 P51812 325 5.00e-02 1 3 1 0.333 1.000 HP:0006129 hp 1 Drumstick terminal phalanges 1 P51812 325 5.00e-02 121 3 1 0.333 0.008 GO:0043281 BP 1 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 P51812 325 5.00e-02 1 3 1 0.333 1.000 OMIM:300844 omi 1 MENTAL RETARDATION, X-LINKED 19; MRX19 1 P51812 325 5.00e-02 1 3 1 0.333 1.000 OMIM:303600 omi 1 COFFIN-LOWRY SYNDROME; CLS 1 P51812 325 5.00e-02 1 3 1 0.333 1.000 HP:0010309 hp 1 Bifid sternum 1 P51812 325 5.00e-02 1 3 1 0.333 1.000 HP:0009746 hp 1 Thick nasal septum 1 P51812 325 5.00e-02 1127 3 3 1.000 0.003 TF:M01045_0 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 0 1 Q9UJ78,P51812,Q8IV31 325 5.00e-02 1241 3 3 1.000 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q9UJ78,P51812,Q8IV31 326 6.14e-05 10 2 2 1.000 0.200 CORUM:5286 cor 1 TNF-alpha/NF-kappa B signaling complex 10 1 P40222,Q16543 326 3.14e-03 20 2 1 0.500 0.050 TF:M06424_0 tf 1 Factor: ZNF788; motif: KGGGGCAGGTTT; match class: 0 1 Q16543 326 4.40e-03 28 2 1 0.500 0.036 TF:M06376_0 tf 1 Factor: ZNF770; motif: KGGGGGCRATS; match class: 0 1 Q16543 326 6.43e-03 41 2 1 0.500 0.024 TF:M05512_0 tf 1 Factor: ZNF575; motif: NGGTGGGGGGGC; match class: 0 1 Q16543 326 8.00e-03 1139 2 2 1.000 0.002 TF:M03927_0 tf 1 Factor: ZBTB7A; motif: NGCGACCACCNN; match class: 0 1 P40222,Q16543 326 8.15e-03 52 2 1 0.500 0.019 TF:M05601_0 tf 1 Factor: FIZ1; motif: GGGSTMGGCCT; match class: 0 1 P40222 326 9.40e-03 3 2 1 0.500 0.333 CORUM:5849 cor 1 HSP90-CDC37-LRRK2 complex 1 Q16543 326 9.73e-03 1256 2 2 1.000 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 P40222,Q16543 326 1.17e-02 1375 2 2 1.000 0.001 TF:M02074_1 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 1 P40222,Q16543 326 1.25e-02 4 2 1 0.500 0.250 CORUM:2112 cor 1 CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex 1 Q16543 326 1.35e-02 86 2 1 0.500 0.012 TF:M03977_1 tf 1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 1 P40222 326 1.39e-02 89 2 1 0.500 0.011 TF:M04475_0 tf 1 Factor: NR2F6; motif: NRGGTCAAAGGTCA; match class: 0 1 P40222 326 1.57e-02 5 2 1 0.500 0.200 CORUM:5269 cor 1 TNF-alpha/NF-kappa B signaling complex 8 1 Q16543 326 1.57e-02 5 2 1 0.500 0.200 CORUM:5285 cor 1 TNF-alpha/NF-kappa B signaling complex 9 1 Q16543 326 1.57e-02 5 2 1 0.500 0.200 CORUM:5234 cor 1 IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex 1 Q16543 326 1.63e-02 14 2 1 0.500 0.071 REAC:5637810 rea 1 Constitutive Signaling by EGFRvIII 1 Q16543 326 1.63e-02 14 2 1 0.500 0.071 REAC:5637812 rea 1 Signaling by EGFRvIII in Cancer 1 Q16543 326 1.64e-02 105 2 1 0.500 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 P40222 326 1.94e-02 1775 2 2 1.000 0.001 TF:M00430_1 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 1 P40222,Q16543 326 1.98e-02 17 2 1 0.500 0.059 REAC:1236382 rea 1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1 Q16543 326 1.98e-02 17 2 1 0.500 0.059 REAC:1643713 rea 1 Signaling by EGFR in Cancer 1 Q16543 326 1.98e-02 17 2 1 0.500 0.059 REAC:5637815 rea 1 Signaling by Ligand-Responsive EGFR Variants in Cancer 1 Q16543 326 2.03e-02 130 2 1 0.500 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 P40222 326 2.13e-02 1859 2 2 1.000 0.001 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 P40222,Q16543 326 2.19e-02 7 2 1 0.500 0.143 CORUM:5212 cor 1 Kinase maturation complex 2 1 Q16543 326 2.27e-02 1920 2 2 1.000 0.001 TF:M00736_0 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 0 1 P40222,Q16543 326 2.30e-02 147 2 1 0.500 0.007 TF:M05303_0 tf 1 Factor: ZNF536; motif: NCWGSTGCTA; match class: 0 1 P40222 326 2.34e-02 1949 2 2 1.000 0.001 TF:M02067_1 tf 1 Factor: ER71; motif: ACCGGAARYN; match class: 1 1 P40222,Q16543 326 2.38e-02 1966 2 2 1.000 0.001 TF:M07356_0 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 0 1 P40222,Q16543 326 2.50e-02 8 2 1 0.500 0.125 CORUM:5268 cor 1 TNF-alpha/NF-kappa B signaling complex 7 1 Q16543 326 2.51e-02 161 2 1 0.500 0.006 TF:M05322_0 tf 1 Factor: T-box; motif: TTCACACCTR; match class: 0 1 Q16543 326 2.59e-02 2049 2 2 1.000 0.001 TF:M01876_0 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 0 1 P40222,Q16543 326 2.71e-02 2096 2 2 1.000 0.001 TF:M00053_0 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 0 1 P40222,Q16543 326 2.95e-02 189 2 1 0.500 0.005 TF:M00053_1 tf 1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 1 1 Q16543 326 3.21e-02 206 2 1 0.500 0.005 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 P40222 326 4.03e-02 259 2 1 0.500 0.004 TF:M07350_1 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 1 1 Q16543 326 4.24e-02 240 2 1 0.500 0.004 MI:hsa-miR-25* mi 1 MI:hsa-miR-25* 1 Q16543 326 4.38e-02 14 2 1 0.500 0.071 CORUM:5266 cor 1 TNF-alpha/NF-kappa B signaling complex 6 1 Q16543 326 4.43e-02 285 2 1 0.500 0.004 TF:M00257_0 tf 1 Factor: RREB-1; motif: CCCCAAACMMCCCC; match class: 0 1 Q16543 326 4.80e-02 309 2 1 0.500 0.003 TF:M05390_0 tf 1 Factor: TBPL2; motif: CTTTTAAATC; match class: 0 1 P40222 326 4.97e-02 320 2 1 0.500 0.003 TF:M07259_1 tf 1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1 Q16543 326 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q16543 326 5.00e-02 16 2 1 0.500 0.062 CORUM:5613 cor 1 Emerin complex 25 1 Q16543 326 5.00e-02 43 2 1 0.500 0.023 REAC:1227986 rea 1 Signaling by ERBB2 1 Q16543 326 5.00e-02 16 2 1 0.500 0.062 CORUM:5199 cor 1 Kinase maturation complex 1 1 Q16543 326 5.00e-02 1 2 1 0.500 1.000 GO:0030372 MF 1 high molecular weight B cell growth factor receptor binding 1 P40222 327 1.17e-05 13 2 2 1.000 0.154 GO:0034975 BP 1 protein folding in endoplasmic reticulum 1 P27824,P14625 327 4.31e-04 63 2 2 1.000 0.032 KEGG:04918 keg 1 Thyroid hormone synthesis 1 P27824,P14625 327 1.06e-03 2 2 1 0.500 0.500 REAC:168316 rea 1 Assembly of Viral Components at the Budding Site 1 P27824 327 1.06e-03 2 2 1 0.500 0.500 REAC:168268 rea 1 Virus Assembly and Release 1 P27824 327 1.20e-03 127 2 2 1.000 0.016 GO:0005788 CC 1 endoplasmic reticulum lumen 1 P27824,P14625 327 1.58e-03 146 2 2 1.000 0.014 GO:0006898 BP 1 receptor-mediated endocytosis 1 P27824,P14625 327 1.72e-03 152 2 2 1.000 0.013 GO:0006457 BP 1 protein folding 1 P27824,P14625 327 2.53e-03 152 2 2 1.000 0.013 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 P27824,P14625 327 2.57e-03 186 2 2 1.000 0.011 GO:0005509 MF 1 calcium ion binding 1 P27824,P14625 327 3.03e-03 701 2 2 1.000 0.003 TF:M05938_0 tf 1 Factor: ZNF714; motif: NSGKTGGGCCGM; match class: 0 1 P27824,P14625 327 3.45e-03 2 2 1 0.500 0.500 GO:0031247 BP 1 actin rod assembly 1 P14625 327 3.77e-03 24 2 1 0.500 0.042 TF:M06149_0 tf 1 Factor: ZNF132; motif: NGGANTGGCAAA; match class: 0 1 P27824 327 3.77e-03 24 2 1 0.500 0.042 TF:M06583_0 tf 1 Factor: ZNF845; motif: KGGGCAAACGGM; match class: 0 1 P27824 327 4.24e-03 8 2 1 0.500 0.125 REAC:1679131 rea 1 Trafficking and processing of endosomal TLR 1 P14625 327 4.92e-03 257 2 2 1.000 0.008 GO:0031012 CC 1 extracellular matrix 1 P27824,P14625 327 4.99e-03 265 2 2 1.000 0.008 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 P27824,P14625 327 6.31e-03 298 2 2 1.000 0.007 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 P27824,P14625 327 7.14e-03 317 2 2 1.000 0.006 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 P27824,P14625 327 7.81e-03 1125 2 2 1.000 0.002 TF:M04345_0 tf 1 Factor: HOXB13; motif: CCAATAAAAN; match class: 0 1 P27824,P14625 327 7.88e-03 333 2 2 1.000 0.006 HPA:020010_13 hpa 1 lateral ventricle; glial cells[Supportive,High] 1 P27824,P14625 327 7.94e-03 15 2 1 0.500 0.067 REAC:3000480 rea 1 Scavenging by Class A Receptors 1 P14625 327 8.26e-03 341 2 2 1.000 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 P27824,P14625 327 8.94e-03 57 2 1 0.500 0.018 TF:M01650_0 tf 1 Factor: PNR; motif: RAGRTCAAARRTCA; match class: 0 1 P14625 327 9.35e-03 354 2 2 1.000 0.006 GO:0006897 BP 1 endocytosis 1 P27824,P14625 327 1.04e-02 6 2 1 0.500 0.167 GO:0044233 CC 1 ER-mitochondrion membrane contact site 1 P27824 327 1.16e-02 22 2 1 0.500 0.045 REAC:983170 rea 1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1 P27824 327 1.21e-02 7 2 1 0.500 0.143 GO:0071318 BP 1 cellular response to ATP 1 P14625 327 1.21e-02 7 2 1 0.500 0.143 GO:0046790 MF 1 virion binding 1 P14625 327 1.27e-02 24 2 1 0.500 0.042 REAC:901042 rea 1 Calnexin/calreticulin cycle 1 P27824 327 1.34e-02 1476 2 2 1.000 0.001 TF:M02110_1 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 1 1 P27824,P14625 327 1.39e-02 1500 2 2 1.000 0.001 TF:M01108_1 tf 1 Factor: HOXA7; motif: YCAATCT; match class: 1 1 P27824,P14625 327 1.44e-02 92 2 1 0.500 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 P27824 327 1.44e-02 1530 2 2 1.000 0.001 TF:M04363_0 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 0 1 P27824,P14625 327 1.44e-02 1530 2 2 1.000 0.001 TF:M04357_0 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 0 1 P27824,P14625 327 1.49e-02 95 2 1 0.500 0.011 TF:M04356_0 tf 1 Factor: HOXC12; motif: RGTCGTAAAAN; match class: 0 1 P14625 327 1.55e-02 9 2 1 0.500 0.111 GO:0036500 BP 1 ATF6-mediated unfolded protein response 1 P14625 327 1.59e-02 30 2 1 0.500 0.033 REAC:2173782 rea 1 Binding and Uptake of Ligands by Scavenger Receptors 1 P14625 327 1.60e-02 1610 2 2 1.000 0.001 TF:M03563_1 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 1 P27824,P14625 327 1.67e-02 484 2 2 1.000 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P27824,P14625 327 1.67e-02 107 2 1 0.500 0.009 TF:M04163_0 tf 1 Factor: BHLHE41; motif: NKCACGTGMC; match class: 0 1 P27824 327 1.70e-02 489 2 2 1.000 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P27824,P14625 327 1.72e-02 110 2 1 0.500 0.009 TF:M04097_1 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 1 1 P14625 327 1.73e-02 10 2 1 0.500 0.100 GO:0033198 BP 1 response to ATP 1 P14625 327 1.73e-02 10 2 1 0.500 0.100 GO:0044232 CC 1 organelle membrane contact site 1 P27824 327 1.74e-02 33 2 1 0.500 0.030 REAC:532668 rea 1 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 1 P27824 327 1.76e-02 498 2 2 1.000 0.004 HPA:022010_13 hpa 1 lung; macrophages[Supportive,High] 1 P27824,P14625 327 1.84e-02 509 2 2 1.000 0.004 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 P27824,P14625 327 1.95e-02 1778 2 2 1.000 0.001 TF:M01821_1 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 1 1 P27824,P14625 327 2.07e-02 12 2 1 0.500 0.083 GO:0050750 MF 1 low-density lipoprotein particle receptor binding 1 P14625 327 2.07e-02 540 2 2 1.000 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 P27824,P14625 327 2.08e-02 528 2 2 1.000 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 P27824,P14625 327 2.13e-02 534 2 2 1.000 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 P27824,P14625 327 2.19e-02 555 2 2 1.000 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 P27824,P14625 327 2.24e-02 13 2 1 0.500 0.077 GO:0048488 BP 1 synaptic vesicle endocytosis 1 P27824 327 2.24e-02 13 2 1 0.500 0.077 GO:0071682 CC 1 endocytic vesicle lumen 1 P14625 327 2.26e-02 564 2 2 1.000 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 P27824,P14625 327 2.29e-02 567 2 2 1.000 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P27824,P14625 327 2.53e-02 596 2 2 1.000 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 P27824,P14625 327 2.59e-02 2050 2 2 1.000 0.001 TF:M04571_0 tf 1 Factor: TFEC; motif: RNCACRTGAY; match class: 0 1 P27824,P14625 327 2.63e-02 593 2 2 1.000 0.003 GO:0046872 MF 1 metal ion binding 1 P27824,P14625 327 2.63e-02 608 2 2 1.000 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 P27824,P14625 327 2.76e-02 16 2 1 0.500 0.062 GO:0070325 MF 1 lipoprotein particle receptor binding 1 P14625 327 2.77e-02 624 2 2 1.000 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P27824,P14625 327 2.78e-02 625 2 2 1.000 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 P27824,P14625 327 2.81e-02 180 2 1 0.500 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 P14625 327 2.83e-02 631 2 2 1.000 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 P27824,P14625 327 2.86e-02 2153 2 2 1.000 0.001 TF:M04341_0 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 0 1 P27824,P14625 327 2.93e-02 17 2 1 0.500 0.059 GO:0036465 BP 1 synaptic vesicle recycling 1 P27824 327 3.03e-02 652 2 2 1.000 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 P27824,P14625 327 3.08e-02 658 2 2 1.000 0.003 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P27824,P14625 327 3.20e-02 654 2 2 1.000 0.003 GO:0043169 MF 1 cation binding 1 P27824,P14625 327 3.24e-02 658 2 2 1.000 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 P27824,P14625 327 3.31e-02 682 2 2 1.000 0.003 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 P27824,P14625 327 3.39e-02 2343 2 2 1.000 0.001 TF:M03981_0 tf 1 Factor: ETV3; motif: ACCGGAAGTN; match class: 0 1 P27824,P14625 327 3.45e-02 20 2 1 0.500 0.050 GO:0071556 CC 1 integral component of lumenal side of endoplasmic reticulum membrane 1 P27824 327 3.45e-02 20 2 1 0.500 0.050 GO:0098553 CC 1 lumenal side of endoplasmic reticulum membrane 1 P27824 327 3.47e-02 2372 2 2 1.000 0.001 TF:M04627_0 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 0 1 P27824,P14625 327 3.48e-02 2375 2 2 1.000 0.001 TF:M02072_0 tf 1 Factor: Pet-1; motif: ACCGGAWRTN; match class: 0 1 P27824,P14625 327 3.55e-02 228 2 1 0.500 0.004 TF:M07084_0 tf 1 Factor: E2F-4; motif: NGGCGGGAARN; match class: 0 1 P27824 327 3.55e-02 228 2 1 0.500 0.004 TF:M04341_1 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 1 1 P14625 327 3.63e-02 233 2 1 0.500 0.004 TF:M04099_1 tf 1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 1 P14625 327 3.70e-02 238 2 1 0.500 0.004 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 P14625 327 3.77e-02 242 2 1 0.500 0.004 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 P14625 327 3.79e-02 730 2 2 1.000 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 P27824,P14625 327 3.85e-02 2497 2 2 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 P27824,P14625 327 4.04e-02 753 2 2 1.000 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P27824,P14625 327 4.04e-02 260 2 1 0.500 0.004 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 P14625 327 4.06e-02 755 2 2 1.000 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 P27824,P14625 327 4.11e-02 78 2 1 0.500 0.013 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 P14625 327 4.12e-02 761 2 2 1.000 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P27824,P14625 327 4.17e-02 268 2 1 0.500 0.004 TF:M04362_0 tf 1 Factor: HOXD12; motif: RGTCGTAAAAN; match class: 0 1 P14625 327 4.28e-02 775 2 2 1.000 0.003 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P27824,P14625 327 4.31e-02 25 2 1 0.500 0.040 GO:0043666 BP 1 regulation of phosphoprotein phosphatase activity 1 P14625 327 4.34e-02 781 2 2 1.000 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P27824,P14625 327 4.46e-02 287 2 1 0.500 0.003 TF:M01797_1 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 1 1 P14625 327 4.46e-02 287 2 1 0.500 0.003 TF:M06078_0 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 0 1 P14625 327 4.48e-02 26 2 1 0.500 0.038 GO:1903513 BP 1 endoplasmic reticulum to cytosol transport 1 P14625 327 4.48e-02 26 2 1 0.500 0.038 GO:0030970 BP 1 retrograde protein transport, ER to cytosol 1 P14625 327 4.51e-02 2702 2 2 1.000 0.001 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 P27824,P14625 327 4.53e-02 798 2 2 1.000 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P27824,P14625 327 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 P27824,P14625 327 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 P14625 327 4.78e-02 308 2 1 0.500 0.003 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 P14625 327 4.85e-02 2804 2 2 1.000 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 P27824,P14625 327 4.86e-02 313 2 1 0.500 0.003 TF:M04627_1 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 1 1 P27824 327 4.89e-02 2816 2 2 1.000 0.001 TF:M07315_1 tf 1 Factor: C/EBPbeta; motif: NNTTKCNNMAN; match class: 1 1 P27824,P14625 327 4.98e-02 836 2 2 1.000 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P27824,P14625 327 5.00e-02 95 2 1 0.500 0.011 REAC:2132295 rea 1 MHC class II antigen presentation 1 P27824 327 5.00e-02 29 2 1 0.500 0.034 GO:0006984 BP 1 ER-nucleus signaling pathway 1 P14625 327 5.00e-02 45 2 1 0.500 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P27824 327 5.00e-02 838 2 2 1.000 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P27824,P14625 328 5.28e-04 324 3 3 1.000 0.009 GO:0005975 BP 1 carbohydrate metabolic process 1 P36871,P30837,Q01415 328 6.81e-04 62 3 2 0.667 0.032 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P36871,P30837 328 2.12e-03 9 3 1 0.333 0.111 TF:M04171_1 tf 1 Factor: HES-7; motif: YGGCACGTGCCR; match class: 1 1 Q01415 328 2.12e-03 9 3 1 0.333 0.111 TF:M04171_0 tf 1 Factor: HES-7; motif: YGGCACGTGCCR; match class: 0 1 Q01415 328 3.53e-03 1939 3 3 1.000 0.002 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 P36871,P30837,Q01415 328 4.16e-03 2048 3 3 1.000 0.001 TF:M02011_1 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 1 P36871,P30837,Q01415 328 4.55e-03 503 3 2 0.667 0.004 TF:M07213_0 tf 1 Factor: GATA2; motif: NNNTTCTTATCTSN; match class: 0 1 P36871,P30837 328 5.59e-03 5 3 1 0.333 0.200 REAC:70370 rea 1 Galactose catabolism 1 P36871 328 5.88e-03 25 3 1 0.333 0.040 TF:M06861_0 tf 1 Factor: ZNF484; motif: NGRTAGGGGAAA; match class: 0 1 P30837 328 5.98e-03 508 3 2 0.667 0.004 MI:hsa-miR-451 mi 1 MI:hsa-miR-451 1 P30837,Q01415 328 8.93e-03 8 3 1 0.333 0.125 REAC:71384 rea 1 Ethanol oxidation 1 P30837 328 9.87e-03 42 3 1 0.333 0.024 TF:M04338_0 tf 1 Factor: HNF1B; motif: NRTTAATNATTAACN; match class: 0 1 P30837 328 1.07e-02 2808 3 3 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 P36871,P30837,Q01415 328 1.08e-02 2813 3 3 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 P36871,P30837,Q01415 328 1.19e-02 2909 3 3 1.000 0.001 TF:M04435_0 tf 1 Factor: RAX; motif: NNYAATTANN; match class: 0 1 P36871,P30837,Q01415 328 1.20e-02 51 3 1 0.333 0.020 TF:M06454_0 tf 1 Factor: ZNF786; motif: KGGWTYAGGGGA; match class: 0 1 P30837 328 1.22e-02 52 3 1 0.333 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 P30837 328 1.25e-02 2 3 1 0.333 0.500 GO:0004335 MF 1 galactokinase activity 1 Q01415 328 1.56e-02 14 3 1 0.333 0.071 REAC:3322077 rea 1 Glycogen synthesis 1 P36871 328 1.56e-02 14 3 1 0.333 0.071 REAC:70221 rea 1 Glycogen breakdown (glycogenolysis) 1 P36871 328 1.57e-02 67 3 1 0.333 0.015 TF:M06487_0 tf 1 Factor: ZNF695; motif: NTKTAAGGAGNT; match class: 0 1 Q01415 328 1.65e-02 18 3 1 0.333 0.056 KEGG:00340 keg 1 Histidine metabolism 1 P30837 328 1.66e-02 71 3 1 0.333 0.014 TF:M04337_0 tf 1 Factor: HNF1B; motif: GTTAATNATTAAY; match class: 0 1 P30837 328 1.67e-02 4 3 1 0.333 0.250 HP:0005305 hp 1 Cerebral venous thrombosis 1 P36871 328 1.69e-02 72 3 1 0.333 0.014 TF:M01124_1 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1 P36871 328 1.76e-02 75 3 1 0.333 0.013 TF:M06462_0 tf 1 Factor: ZNF441; motif: KGKTCTTGMTSG; match class: 0 1 P30837 328 1.83e-02 78 3 1 0.333 0.013 TF:M06741_0 tf 1 Factor: ZNF70; motif: NGGWCAAAAAGM; match class: 0 1 Q01415 328 1.83e-02 20 3 1 0.333 0.050 KEGG:00053 keg 1 Ascorbate and aldarate metabolism 1 P30837 328 1.87e-02 80 3 1 0.333 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 P36871 328 1.88e-02 3 3 1 0.333 0.333 GO:0004614 MF 1 phosphoglucomutase activity 1 P36871 328 1.94e-02 83 3 1 0.333 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 P36871 328 1.99e-02 3450 3 3 1.000 0.001 TF:M00750_1 tf 1 Factor: HMGIY; motif: GGAAAWT; match class: 1 1 P36871,P30837,Q01415 328 2.15e-02 92 3 1 0.333 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 P30837 328 2.16e-02 3547 3 3 1.000 0.001 TF:M00413_0 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 0 1 P36871,P30837,Q01415 328 2.29e-02 25 3 1 0.333 0.040 KEGG:00052 keg 1 Galactose metabolism 1 P36871 328 2.36e-02 101 3 1 0.333 0.010 TF:M06317_0 tf 1 Factor: ZNF829; motif: KGGGSCARACGC; match class: 0 1 P36871 328 2.38e-02 26 3 1 0.333 0.038 KEGG:00410 keg 1 beta-Alanine metabolism 1 P30837 328 2.38e-02 26 3 1 0.333 0.038 KEGG:00500 keg 1 Starch and sucrose metabolism 1 P36871 328 2.38e-02 26 3 1 0.333 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 P36871 328 2.39e-02 102 3 1 0.333 0.010 TF:M04336_0 tf 1 Factor: HNF1A; motif: NRTTAATNATTAACN; match class: 0 1 P30837 328 2.43e-02 104 3 1 0.333 0.010 TF:M06220_0 tf 1 Factor: ZNF155; motif: NWGATTWACTGM; match class: 0 1 P30837 328 2.49e-02 1197 3 2 0.667 0.002 TF:M01125_0 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 0 1 P36871,Q01415 328 2.74e-02 30 3 1 0.333 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 P30837 328 2.91e-02 3917 3 3 1.000 0.001 TF:M04333_0 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 0 1 P36871,P30837,Q01415 328 2.92e-02 7 3 1 0.333 0.143 HP:0001976 hp 1 Reduced antithrombin III activity 1 P36871 328 2.94e-02 1108 3 2 0.667 0.002 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 P36871,P30837 328 3.13e-02 134 3 1 0.333 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q01415 328 3.15e-02 135 3 1 0.333 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 P30837 328 3.24e-02 139 3 1 0.333 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 P30837 328 3.26e-02 4067 3 3 1.000 0.001 TF:M00346_1 tf 1 Factor: GATA-1; motif: NCWGATAACA; match class: 1 1 P36871,P30837,Q01415 328 3.31e-02 142 3 1 0.333 0.007 TF:M07115_0 tf 1 Factor: NF-YB; motif: NNNYNRRCCAATCAG; match class: 0 1 P36871 328 3.43e-02 147 3 1 0.333 0.007 TF:M00203_1 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 1 1 P36871 328 3.47e-02 38 3 1 0.333 0.026 KEGG:00071 keg 1 Fatty acid degradation 1 P30837 328 3.47e-02 38 3 1 0.333 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P30837 328 3.49e-02 4160 3 3 1.000 0.001 TF:M01722_1 tf 1 Factor: RORbeta; motif: TGACCYA; match class: 1 1 P36871,P30837,Q01415 328 3.59e-02 154 3 1 0.333 0.006 TF:M04236_1 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 1 1 Q01415 328 3.75e-02 9 3 1 0.333 0.111 HP:0010988 hp 1 Abnormality of the extrinsic pathway 1 P36871 328 3.92e-02 43 3 1 0.333 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 P30837 328 4.00e-02 172 3 1 0.333 0.006 TF:M04254_1 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 1 1 Q01415 328 4.18e-02 1569 3 2 0.667 0.001 TF:M01233_0 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 0 1 P30837,Q01415 328 4.19e-02 46 3 1 0.333 0.022 KEGG:00280 keg 1 Valine, leucine and isoleucine degradation 1 P30837 328 4.19e-02 46 3 1 0.333 0.022 KEGG:00520 keg 1 Amino sugar and nucleotide sugar metabolism 1 P36871 328 4.23e-02 182 3 1 0.333 0.005 TF:M04192_0 tf 1 Factor: TFAP4; motif: AWCAGCTGWT; match class: 0 1 P36871 328 4.37e-02 48 3 1 0.333 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 P30837 328 4.38e-02 7 3 1 0.333 0.143 GO:0019388 BP 1 galactose catabolic process 1 P36871 328 4.64e-02 200 3 1 0.333 0.005 TF:M07403_0 tf 1 Factor: FOXP2; motif: NWGTAAACARN; match class: 0 1 P36871 328 4.69e-02 202 3 1 0.333 0.005 TF:M06128_0 tf 1 Factor: ZNF3; motif: NGGGCCAACCGM; match class: 0 1 P36871 328 4.82e-02 208 3 1 0.333 0.005 TF:M06154_0 tf 1 Factor: ZNF132; motif: NTTRGAAATGTTYM; match class: 0 1 P36871 328 4.89e-02 1703 3 2 0.667 0.001 TF:M03835_0 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 0 1 P36871,P30837 328 4.92e-02 1708 3 2 0.667 0.001 TF:M00203_0 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 0 1 P36871,P30837 328 5.00e-02 8 3 1 0.333 0.125 GO:0006069 BP 1 ethanol oxidation 1 P30837 328 5.00e-02 8 3 1 0.333 0.125 GO:0006067 BP 1 ethanol metabolic process 1 P30837 328 5.00e-02 1 3 1 0.333 1.000 OMIM:614921 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE It; CDG1T;;CDG It; CDGIt;;PHOSPHOGLUCOMUTASE 1 DEFICIENCY;;PGM1 DEFICIENCY;;GLYCOGEN STORAGE DISEASE XIV; GSD14;;GSD XIV 1 P36871 328 5.00e-02 55 3 1 0.333 0.018 KEGG:00310 keg 1 Lysine degradation 1 P30837 328 5.00e-02 8 3 1 0.333 0.125 GO:0006012 BP 1 galactose metabolic process 1 P36871 328 5.00e-02 45 3 1 0.333 0.022 REAC:211945 rea 1 Phase 1 - Functionalization of compounds 1 P30837 328 5.00e-02 12 3 1 0.333 0.083 HP:0000201 hp 1 Pierre-Robin sequence 1 P36871 329 6.34e-05 49 2 2 1.000 0.041 GO:0031463 CC 1 Cul3-RING ubiquitin ligase complex 1 Q13618,Q9P2K6 329 5.03e-04 137 2 2 1.000 0.015 GO:0031461 CC 1 cullin-RING ubiquitin ligase complex 1 Q13618,Q9P2K6 329 6.22e-04 1 2 1 0.500 1.000 GO:0031208 MF 1 POZ domain binding 1 Q13618 329 6.22e-04 1 2 1 0.500 1.000 GO:0040016 BP 1 embryonic cleavage 1 Q13618 329 1.22e-03 213 2 2 1.000 0.009 GO:0000209 BP 1 protein polyubiquitination 1 Q13618,Q9P2K6 329 1.37e-03 226 2 2 1.000 0.009 GO:0000151 CC 1 ubiquitin ligase complex 1 Q13618,Q9P2K6 329 2.45e-03 302 2 2 1.000 0.007 GO:0004842 MF 1 ubiquitin-protein transferase activity 1 Q13618,Q9P2K6 329 2.53e-03 307 2 2 1.000 0.007 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 Q13618,Q9P2K6 329 2.72e-03 318 2 2 1.000 0.006 GO:0019787 MF 1 ubiquitin-like protein transferase activity 1 Q13618,Q9P2K6 329 2.83e-03 18 2 1 0.500 0.056 TF:M05832_0 tf 1 Factor: ZNF620; motif: NGCTKWAAACGM; match class: 0 1 Q13618 329 2.84e-03 325 2 2 1.000 0.006 GO:0010498 BP 1 proteasomal protein catabolic process 1 Q13618,Q9P2K6 329 3.11e-03 5 2 1 0.500 0.200 GO:0005827 CC 1 polar microtubule 1 Q13618 329 3.14e-03 20 2 1 0.500 0.050 TF:M00248_0 tf 1 Factor: Oct-1; motif: TNTATGBTAATT; match class: 0 1 Q13618 329 3.73e-03 6 2 1 0.500 0.167 GO:1901970 BP 1 positive regulation of mitotic sister chromatid separation 1 Q13618 329 3.73e-03 6 2 1 0.500 0.167 GO:0045842 BP 1 positive regulation of mitotic metaphase/anaphase transition 1 Q13618 329 3.73e-03 6 2 1 0.500 0.167 GO:1902101 BP 1 positive regulation of metaphase/anaphase transition of cell cycle 1 Q13618 329 4.29e-03 834 2 2 1.000 0.002 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 Q13618,Q9P2K6 329 4.39e-03 404 2 2 1.000 0.005 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 Q13618,Q9P2K6 329 4.48e-03 408 2 2 1.000 0.005 GO:0019941 BP 1 modification-dependent protein catabolic process 1 Q13618,Q9P2K6 329 4.66e-03 416 2 2 1.000 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q13618,Q9P2K6 329 4.98e-03 8 2 1 0.500 0.125 GO:0035024 BP 1 negative regulation of Rho protein signal transduction 1 Q13618 329 5.34e-03 34 2 1 0.500 0.029 TF:M06143_0 tf 1 Factor: ZNF16; motif: NGTKGCTTAAKA; match class: 0 1 Q13618 329 5.67e-03 459 2 2 1.000 0.004 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 Q13618,Q9P2K6 329 5.74e-03 462 2 2 1.000 0.004 GO:0016567 BP 1 protein ubiquitination 1 Q13618,Q9P2K6 329 6.31e-03 484 2 2 1.000 0.004 GO:0044257 BP 1 cellular protein catabolic process 1 Q13618,Q9P2K6 329 7.84e-03 50 2 1 0.500 0.020 TF:M05674_0 tf 1 Factor: ZNF235; motif: NGGTTAAAGATM; match class: 0 1 Q13618 329 8.44e-03 560 2 2 1.000 0.004 GO:0030163 BP 1 protein catabolic process 1 Q13618,Q9P2K6 329 8.53e-03 1176 2 2 1.000 0.002 TF:M01124_0 tf 1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 0 1 Q13618,Q9P2K6 329 8.62e-03 55 2 1 0.500 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q9P2K6 329 8.84e-03 573 2 2 1.000 0.003 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q13618,Q9P2K6 329 9.09e-03 58 2 1 0.500 0.017 TF:M03912_0 tf 1 Factor: KLF13; motif: NTGMCACGCCCCTTTTTG; match class: 0 1 Q13618 329 9.33e-03 15 2 1 0.500 0.067 GO:0017145 BP 1 stem cell division 1 Q13618 329 9.88e-03 63 2 1 0.500 0.016 TF:M06611_0 tf 1 Factor: ZNF560; motif: NNGTGGGKCAGC; match class: 0 1 Q9P2K6 329 1.05e-02 624 2 2 1.000 0.003 GO:1990234 CC 1 transferase complex 1 Q13618,Q9P2K6 329 1.14e-02 1361 2 2 1.000 0.001 TF:M07379_1 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 1 1 Q13618,Q9P2K6 329 1.16e-02 74 2 1 0.500 0.014 TF:M06627_0 tf 1 Factor: ZNF570; motif: NTGTWAARCATA; match class: 0 1 Q13618 329 1.18e-02 75 2 1 0.500 0.013 TF:M06020_0 tf 1 Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 0 1 Q9P2K6 329 1.18e-02 662 2 2 1.000 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q13618,Q9P2K6 329 1.22e-02 78 2 1 0.500 0.013 TF:M05949_0 tf 1 Factor: ZNF714; motif: NGGGAAGGAAGM; match class: 0 1 Q9P2K6 329 1.24e-02 20 2 1 0.500 0.050 GO:0051984 BP 1 positive regulation of chromosome segregation 1 Q13618 329 1.25e-02 1 2 1 0.500 1.000 OMIM:614496 omi 1 PSEUDOHYPOALDOSTERONISM, TYPE IIE; PHA2E 1 Q13618 329 1.37e-02 22 2 1 0.500 0.045 GO:0046580 BP 1 negative regulation of Ras protein signal transduction 1 Q13618 329 1.37e-02 1492 2 2 1.000 0.001 TF:M01002_0 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 0 1 Q13618,Q9P2K6 329 1.42e-02 727 2 2 1.000 0.003 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q13618,Q9P2K6 329 1.43e-02 23 2 1 0.500 0.043 GO:0051058 BP 1 negative regulation of small GTPase mediated signal transduction 1 Q13618 329 1.44e-02 92 2 1 0.500 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 Q9P2K6 329 1.54e-02 1581 2 2 1.000 0.001 TF:M04108_0 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 0 1 Q13618,Q9P2K6 329 1.55e-02 25 2 1 0.500 0.040 GO:0045840 BP 1 positive regulation of mitotic nuclear division 1 Q13618 329 1.55e-02 25 2 1 0.500 0.040 GO:0032467 BP 1 positive regulation of cytokinesis 1 Q13618 329 1.61e-02 103 2 1 0.500 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q9P2K6 329 1.80e-02 29 2 1 0.500 0.034 GO:0051785 BP 1 positive regulation of nuclear division 1 Q13618 329 1.80e-02 29 2 1 0.500 0.034 GO:0051781 BP 1 positive regulation of cell division 1 Q13618 329 1.88e-02 3 2 1 0.500 0.333 CORUM:1225 cor 1 Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) 1 Q13618 329 1.88e-02 3 2 1 0.500 0.333 CORUM:1243 cor 1 Ubiquitin E3 ligase (SPOP, DAXX, CUL3) 1 Q13618 329 1.88e-02 3 2 1 0.500 0.333 CORUM:222 cor 1 CAND1-CUL3-RBX1 complex 1 Q13618 329 1.88e-02 3 2 1 0.500 0.333 CORUM:1224 cor 1 Ubiquitin E3 ligase (BMI1, SPOP, CUL3) 1 Q13618 329 1.93e-02 31 2 1 0.500 0.032 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 Q13618 329 2.05e-02 33 2 1 0.500 0.030 GO:0035023 BP 1 regulation of Rho protein signal transduction 1 Q13618 329 2.07e-02 876 2 2 1.000 0.002 GO:0009057 BP 1 macromolecule catabolic process 1 Q13618,Q9P2K6 329 2.11e-02 34 2 1 0.500 0.029 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 Q13618 329 2.17e-02 35 2 1 0.500 0.029 GO:0030071 BP 1 regulation of mitotic metaphase/anaphase transition 1 Q13618 329 2.24e-02 36 2 1 0.500 0.028 GO:1902099 BP 1 regulation of metaphase/anaphase transition of cell cycle 1 Q13618 329 2.30e-02 37 2 1 0.500 0.027 GO:0007091 BP 1 metaphase/anaphase transition of mitotic cell cycle 1 Q13618 329 2.30e-02 37 2 1 0.500 0.027 GO:0010965 BP 1 regulation of mitotic sister chromatid separation 1 Q13618 329 2.35e-02 1953 2 2 1.000 0.001 TF:M00428_1 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 1 Q13618,Q9P2K6 329 2.36e-02 38 2 1 0.500 0.026 GO:0051306 BP 1 mitotic sister chromatid separation 1 Q13618 329 2.36e-02 38 2 1 0.500 0.026 GO:0044784 BP 1 metaphase/anaphase transition of cell cycle 1 Q13618 329 2.37e-02 937 2 2 1.000 0.002 GO:0006508 BP 1 proteolysis 1 Q13618,Q9P2K6 329 2.50e-02 4 2 1 0.500 0.250 HP:0011423 hp 1 Hyperchloremia 1 Q13618 329 2.50e-02 136 2 1 0.500 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q13618 329 2.55e-02 41 2 1 0.500 0.024 GO:0007080 BP 1 mitotic metaphase plate congression 1 Q13618 329 2.65e-02 170 2 1 0.500 0.006 TF:M06125_0 tf 1 Factor: ZNF823; motif: NGRGGGAGGAGG; match class: 0 1 Q9P2K6 329 2.72e-02 2098 2 2 1.000 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q13618,Q9P2K6 329 2.72e-02 148 2 1 0.500 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q13618 329 2.73e-02 44 2 1 0.500 0.023 GO:0033047 BP 1 regulation of mitotic sister chromatid segregation 1 Q13618 329 2.75e-02 176 2 1 0.500 0.006 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 Q13618 329 2.75e-02 2110 2 2 1.000 0.001 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 Q13618,Q9P2K6 329 2.86e-02 46 2 1 0.500 0.022 GO:0006513 BP 1 protein monoubiquitination 1 Q13618 329 2.88e-02 1033 2 2 1.000 0.002 GO:1902494 CC 1 catalytic complex 1 Q13618,Q9P2K6 329 2.94e-02 160 2 1 0.500 0.006 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 Q13618 329 2.95e-02 189 2 1 0.500 0.005 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 Q9P2K6 329 2.96e-02 190 2 1 0.500 0.005 TF:M01592_1 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 1 1 Q9P2K6 329 2.98e-02 48 2 1 0.500 0.021 GO:0005876 CC 1 spindle microtubule 1 Q13618 329 2.98e-02 48 2 1 0.500 0.021 GO:0051310 BP 1 metaphase plate congression 1 Q13618 329 2.98e-02 48 2 1 0.500 0.021 GO:0043149 BP 1 stress fiber assembly 1 Q13618 329 2.98e-02 48 2 1 0.500 0.021 GO:0030038 BP 1 contractile actin filament bundle assembly 1 Q13618 329 2.98e-02 48 2 1 0.500 0.021 GO:0007229 BP 1 integrin-mediated signaling pathway 1 Q13618 329 3.03e-02 194 2 1 0.500 0.005 TF:M06860_0 tf 1 Factor: ZNF549; motif: NCTTTTWTGGGA; match class: 0 1 Q13618 329 3.04e-02 49 2 1 0.500 0.020 GO:0032465 BP 1 regulation of cytokinesis 1 Q13618 329 3.16e-02 2264 2 2 1.000 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q13618,Q9P2K6 329 3.29e-02 53 2 1 0.500 0.019 GO:0051304 BP 1 chromosome separation 1 Q13618 329 3.29e-02 53 2 1 0.500 0.019 GO:0033045 BP 1 regulation of sister chromatid segregation 1 Q13618 329 3.35e-02 54 2 1 0.500 0.019 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 Q13618 329 3.35e-02 54 2 1 0.500 0.019 GO:0048208 BP 1 COPII vesicle coating 1 Q13618 329 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q13618,Q9P2K6 329 3.38e-02 217 2 1 0.500 0.005 TF:M06534_0 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 0 1 Q13618 329 3.41e-02 55 2 1 0.500 0.018 GO:0051303 BP 1 establishment of chromosome localization 1 Q13618 329 3.48e-02 56 2 1 0.500 0.018 GO:0050000 BP 1 chromosome localization 1 Q13618 329 3.48e-02 56 2 1 0.500 0.018 GO:0006901 BP 1 vesicle coating 1 Q13618 329 3.51e-02 1141 2 2 1.000 0.002 GO:0044248 BP 1 cellular catabolic process 1 Q13618,Q9P2K6 329 3.54e-02 57 2 1 0.500 0.018 GO:0090114 BP 1 COPII-coated vesicle budding 1 Q13618 329 3.57e-02 272 2 2 1.000 0.007 REAC:983168 rea 1 Antigen processing: Ubiquitination & Proteasome degradation 1 Q13618,Q9P2K6 329 3.60e-02 58 2 1 0.500 0.017 GO:2001252 BP 1 positive regulation of chromosome organization 1 Q13618 329 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q13618,Q9P2K6 329 3.66e-02 59 2 1 0.500 0.017 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 Q13618 329 3.85e-02 62 2 1 0.500 0.016 GO:0051302 BP 1 regulation of cell division 1 Q13618 329 3.97e-02 64 2 1 0.500 0.016 GO:0007266 BP 1 Rho protein signal transduction 1 Q13618 329 4.02e-02 2165 2 2 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q13618,Q9P2K6 329 4.06e-02 2565 2 2 1.000 0.001 TF:M00821_0 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 0 1 Q13618,Q9P2K6 329 4.09e-02 263 2 1 0.500 0.004 TF:M06291_0 tf 1 Factor: ZNF672; motif: STTGGGGAGC; match class: 0 1 Q9P2K6 329 4.16e-02 67 2 1 0.500 0.015 GO:0006903 BP 1 vesicle targeting 1 Q13618 329 4.22e-02 68 2 1 0.500 0.015 GO:0046578 BP 1 regulation of Ras protein signal transduction 1 Q13618 329 4.28e-02 69 2 1 0.500 0.014 GO:0051983 BP 1 regulation of chromosome segregation 1 Q13618 329 4.28e-02 69 2 1 0.500 0.014 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 Q13618 329 4.40e-02 283 2 1 0.500 0.004 TF:M00424_0 tf 1 Factor: Nkx6-1; motif: TWTTTAATTGGTT; match class: 0 1 Q13618 329 4.49e-02 1290 2 2 1.000 0.002 GO:1901575 BP 1 organic substance catabolic process 1 Q13618,Q9P2K6 329 4.56e-02 2719 2 2 1.000 0.001 TF:M03806_0 tf 1 Factor: ZBTB7C; motif: GKCCCGGGCKG; match class: 0 1 Q13618,Q9P2K6 329 4.57e-02 294 2 1 0.500 0.003 TF:M00821_1 tf 1 Factor: Nrf-2; motif: NTGCTGAGTCAKN; match class: 1 1 Q13618 329 4.67e-02 301 2 1 0.500 0.003 TF:M07102_0 tf 1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 0 1 Q13618 329 4.78e-02 77 2 1 0.500 0.013 GO:0031145 BP 1 anaphase-promoting complex-dependent catabolic process 1 Q13618 329 4.78e-02 77 2 1 0.500 0.013 GO:0000922 CC 1 spindle pole 1 Q13618 329 4.85e-02 2804 2 2 1.000 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 Q13618,Q9P2K6 329 4.89e-02 315 2 1 0.500 0.003 TF:M00740_1 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 1 Q9P2K6 329 5.00e-02 37 2 1 0.500 0.027 KEGG:04340 keg 1 Hedgehog signaling pathway 1 Q13618 329 5.00e-02 8 2 1 0.500 0.125 HP:0008242 hp 1 Pseudohypoaldosteronism 1 Q13618 329 5.00e-02 8 2 1 0.500 0.125 CORUM:2715 cor 1 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) 1 Q13618 329 5.00e-02 1362 2 2 1.000 0.001 GO:0009056 BP 1 catabolic process 1 Q13618,Q9P2K6 329 5.00e-02 4 2 1 0.500 0.250 OMIM:145260 omi 1 Pseudohypoaldosteronism Type II 1 Q13618 329 5.00e-02 322 2 2 1.000 0.006 REAC:983169 rea 1 Class I MHC mediated antigen processing & presentation 1 Q13618,Q9P2K6 330 8.40e-07 9 2 2 1.000 0.222 GO:0042613 CC 1 MHC class II protein complex 1 P01912,Q30154 330 1.54e-06 12 2 2 1.000 0.167 GO:0042611 CC 1 MHC protein complex 1 P01912,Q30154 330 2.80e-06 16 2 2 1.000 0.125 GO:0042605 MF 1 peptide antigen binding 1 P01912,Q30154 330 3.68e-06 13 2 2 1.000 0.154 REAC:202430 rea 1 Translocation of ZAP-70 to Immunological synapse 1 P01912,Q30154 330 4.43e-06 20 2 2 1.000 0.100 GO:0071556 CC 1 integral component of lumenal side of endoplasmic reticulum membrane 1 P01912,Q30154 330 4.43e-06 20 2 2 1.000 0.100 GO:0098553 CC 1 lumenal side of endoplasmic reticulum membrane 1 P01912,Q30154 330 4.95e-06 15 2 2 1.000 0.133 REAC:202427 rea 1 Phosphorylation of CD3 and TCR zeta chains 1 P01912,Q30154 330 5.66e-06 16 2 2 1.000 0.125 REAC:389948 rea 1 PD-1 signaling 1 P01912,Q30154 330 1.39e-05 35 2 2 1.000 0.057 GO:0031902 CC 1 late endosome membrane 1 P01912,Q30154 330 1.53e-05 26 2 2 1.000 0.077 REAC:202433 rea 1 Generation of second messenger molecules 1 P01912,Q30154 330 1.55e-05 37 2 2 1.000 0.054 GO:0012507 CC 1 ER to Golgi transport vesicle membrane 1 P01912,Q30154 330 1.64e-05 38 2 2 1.000 0.053 GO:0030669 CC 1 clathrin-coated endocytic vesicle membrane 1 P01912,Q30154 330 1.73e-05 39 2 2 1.000 0.051 GO:0031294 BP 1 lymphocyte costimulation 1 P01912,Q30154 330 1.73e-05 39 2 2 1.000 0.051 GO:0031295 BP 1 T cell costimulation 1 P01912,Q30154 330 2.01e-05 42 2 2 1.000 0.048 GO:0003823 MF 1 antigen binding 1 P01912,Q30154 330 2.41e-05 46 2 2 1.000 0.043 GO:0045334 CC 1 clathrin-coated endocytic vesicle 1 P01912,Q30154 330 3.34e-05 54 2 2 1.000 0.037 GO:0030665 CC 1 clathrin-coated vesicle membrane 1 P01912,Q30154 330 3.34e-05 54 2 2 1.000 0.037 GO:0030134 CC 1 ER to Golgi transport vesicle 1 P01912,Q30154 330 3.59e-05 56 2 2 1.000 0.036 GO:0060333 BP 1 interferon-gamma-mediated signaling pathway 1 P01912,Q30154 330 5.80e-05 71 2 2 1.000 0.028 GO:0032588 CC 1 trans-Golgi network membrane 1 P01912,Q30154 330 5.96e-05 72 2 2 1.000 0.028 GO:0071346 BP 1 cellular response to interferon-gamma 1 P01912,Q30154 330 6.13e-05 73 2 2 1.000 0.027 GO:0030658 CC 1 transport vesicle membrane 1 P01912,Q30154 330 6.50e-05 53 2 2 1.000 0.038 REAC:388841 rea 1 Costimulation by the CD28 family 1 P01912,Q30154 330 7.56e-05 81 2 2 1.000 0.025 GO:0034341 BP 1 response to interferon-gamma 1 P01912,Q30154 330 7.56e-05 81 2 2 1.000 0.025 GO:0019886 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class II 1 P01912,Q30154 330 7.75e-05 82 2 2 1.000 0.024 GO:0002495 BP 1 antigen processing and presentation of peptide antigen via MHC class II 1 P01912,Q30154 330 7.94e-05 83 2 2 1.000 0.024 GO:0002504 BP 1 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1 P01912,Q30154 330 9.98e-05 93 2 2 1.000 0.022 GO:0050870 BP 1 positive regulation of T cell activation 1 P01912,Q30154 330 1.01e-04 66 2 2 1.000 0.030 REAC:877300 rea 1 Interferon gamma signaling 1 P01912,Q30154 330 1.04e-04 95 2 2 1.000 0.021 GO:1903039 BP 1 positive regulation of leukocyte cell-cell adhesion 1 P01912,Q30154 330 1.09e-04 97 2 2 1.000 0.021 GO:0030662 CC 1 coated vesicle membrane 1 P01912,Q30154 330 1.09e-04 97 2 2 1.000 0.021 GO:0030666 CC 1 endocytic vesicle membrane 1 P01912,Q30154 330 1.13e-04 99 2 2 1.000 0.020 GO:0030136 CC 1 clathrin-coated vesicle 1 P01912,Q30154 330 1.16e-04 11 2 2 1.000 0.182 KEGG:05310 keg 1 Asthma 1 P01912,Q30154 330 1.25e-04 104 2 2 1.000 0.019 GO:0030176 CC 1 integral component of endoplasmic reticulum membrane 1 P01912,Q30154 330 1.35e-04 108 2 2 1.000 0.019 GO:0031227 CC 1 intrinsic component of endoplasmic reticulum membrane 1 P01912,Q30154 330 1.37e-04 109 2 2 1.000 0.018 GO:0022409 BP 1 positive regulation of cell-cell adhesion 1 P01912,Q30154 330 1.53e-04 115 2 2 1.000 0.017 GO:0005770 CC 1 late endosome 1 P01912,Q30154 330 1.53e-04 115 2 2 1.000 0.017 GO:0051251 BP 1 positive regulation of lymphocyte activation 1 P01912,Q30154 330 1.58e-04 117 2 2 1.000 0.017 GO:0042277 MF 1 peptide binding 1 P01912,Q30154 330 1.64e-04 119 2 2 1.000 0.017 GO:0050863 BP 1 regulation of T cell activation 1 P01912,Q30154 330 1.75e-04 123 2 2 1.000 0.016 GO:1903037 BP 1 regulation of leukocyte cell-cell adhesion 1 P01912,Q30154 330 1.78e-04 124 2 2 1.000 0.016 GO:0050852 BP 1 T cell receptor signaling pathway 1 P01912,Q30154 330 1.81e-04 125 2 2 1.000 0.016 GO:0098797 CC 1 plasma membrane protein complex 1 P01912,Q30154 330 1.85e-04 89 2 2 1.000 0.022 REAC:202424 rea 1 Downstream TCR signaling 1 P01912,Q30154 330 1.87e-04 127 2 2 1.000 0.016 GO:0002696 BP 1 positive regulation of leukocyte activation 1 P01912,Q30154 330 1.93e-04 129 2 2 1.000 0.016 GO:0033218 MF 1 amide binding 1 P01912,Q30154 330 2.02e-04 132 2 2 1.000 0.015 GO:0050867 BP 1 positive regulation of cell activation 1 P01912,Q30154 330 2.10e-04 95 2 2 1.000 0.021 REAC:2132295 rea 1 MHC class II antigen presentation 1 P01912,Q30154 330 2.37e-04 143 2 2 1.000 0.014 GO:0002478 BP 1 antigen processing and presentation of exogenous peptide antigen 1 P01912,Q30154 330 2.37e-04 143 2 2 1.000 0.014 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 P01912,Q30154 330 2.40e-04 144 2 2 1.000 0.014 GO:0019884 BP 1 antigen processing and presentation of exogenous antigen 1 P01912,Q30154 330 2.50e-04 147 2 2 1.000 0.014 GO:0005802 CC 1 trans-Golgi network 1 P01912,Q30154 330 2.61e-04 150 2 2 1.000 0.013 GO:0048002 BP 1 antigen processing and presentation of peptide antigen 1 P01912,Q30154 330 2.62e-04 106 2 2 1.000 0.019 REAC:202403 rea 1 TCR signaling 1 P01912,Q30154 330 2.71e-04 153 2 2 1.000 0.013 GO:0051249 BP 1 regulation of lymphocyte activation 1 P01912,Q30154 330 2.97e-04 160 2 2 1.000 0.013 GO:0030135 CC 1 coated vesicle 1 P01912,Q30154 330 3.23e-04 167 2 2 1.000 0.012 GO:0022407 BP 1 regulation of cell-cell adhesion 1 P01912,Q30154 330 3.23e-04 18 2 2 1.000 0.111 KEGG:05330 keg 1 Allograft rejection 1 P01912,Q30154 330 3.27e-04 168 2 2 1.000 0.012 GO:0045785 BP 1 positive regulation of cell adhesion 1 P01912,Q30154 330 3.31e-04 169 2 2 1.000 0.012 GO:0098791 CC 1 Golgi subcompartment 1 P01912,Q30154 330 3.43e-04 172 2 2 1.000 0.012 GO:0070489 BP 1 T cell aggregation 1 P01912,Q30154 330 3.43e-04 172 2 2 1.000 0.012 GO:0042110 BP 1 T cell activation 1 P01912,Q30154 330 3.47e-04 173 2 2 1.000 0.012 GO:0071593 BP 1 lymphocyte aggregation 1 P01912,Q30154 330 3.47e-04 173 2 2 1.000 0.012 GO:0019882 BP 1 antigen processing and presentation 1 P01912,Q30154 330 3.67e-04 178 2 2 1.000 0.011 GO:0070486 BP 1 leukocyte aggregation 1 P01912,Q30154 330 3.72e-04 179 2 2 1.000 0.011 GO:0002694 BP 1 regulation of leukocyte activation 1 P01912,Q30154 330 3.80e-04 181 2 2 1.000 0.011 GO:0030139 CC 1 endocytic vesicle 1 P01912,Q30154 330 3.84e-04 182 2 2 1.000 0.011 GO:0031984 CC 1 organelle subcompartment 1 P01912,Q30154 330 4.02e-04 20 2 2 1.000 0.100 KEGG:05332 keg 1 Graft-versus-host disease 1 P01912,Q30154 330 4.19e-04 190 2 2 1.000 0.011 GO:0005765 CC 1 lysosomal membrane 1 P01912,Q30154 330 4.19e-04 190 2 2 1.000 0.011 GO:0098852 CC 1 lytic vacuole membrane 1 P01912,Q30154 330 4.28e-04 192 2 2 1.000 0.010 GO:0030133 CC 1 transport vesicle 1 P01912,Q30154 330 4.44e-04 21 2 2 1.000 0.095 KEGG:04672 keg 1 Intestinal immune network for IgA production 1 P01912,Q30154 330 4.55e-04 198 2 2 1.000 0.010 GO:0007159 BP 1 leukocyte cell-cell adhesion 1 P01912,Q30154 330 4.55e-04 198 2 2 1.000 0.010 GO:0050865 BP 1 regulation of cell activation 1 P01912,Q30154 330 4.60e-04 199 2 2 1.000 0.010 GO:0010008 CC 1 endosome membrane 1 P01912,Q30154 330 5.13e-04 148 2 2 1.000 0.014 REAC:913531 rea 1 Interferon Signaling 1 P01912,Q30154 330 5.35e-04 23 2 2 1.000 0.087 KEGG:04940 keg 1 Type I diabetes mellitus 1 P01912,Q30154 330 5.37e-04 215 2 2 1.000 0.009 GO:0098552 CC 1 side of membrane 1 P01912,Q30154 330 5.38e-04 2 2 1 0.500 0.500 GO:0002505 BP 1 antigen processing and presentation of polysaccharide antigen via MHC class II 1 P01912 330 5.38e-04 2 2 1 0.500 0.500 GO:0065006 BP 1 protein-carbohydrate complex assembly 1 P01912 330 5.38e-04 2 2 1 0.500 0.500 GO:0071823 BP 1 protein-carbohydrate complex subunit organization 1 P01912 330 5.38e-04 2 2 1 0.500 0.500 GO:0002506 BP 1 polysaccharide assembly with MHC class II protein complex 1 P01912 330 5.42e-04 216 2 2 1.000 0.009 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 P01912,Q30154 330 5.42e-04 216 2 2 1.000 0.009 GO:0005774 CC 1 vacuolar membrane 1 P01912,Q30154 330 5.98e-04 227 2 2 1.000 0.009 GO:0044440 CC 1 endosomal part 1 P01912,Q30154 330 6.41e-04 235 2 2 1.000 0.009 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 P01912,Q30154 330 6.58e-04 238 2 2 1.000 0.008 GO:0046649 BP 1 lymphocyte activation 1 P01912,Q30154 330 6.97e-04 245 2 2 1.000 0.008 GO:0030659 CC 1 cytoplasmic vesicle membrane 1 P01912,Q30154 330 7.42e-04 27 2 2 1.000 0.074 KEGG:05320 keg 1 Autoimmune thyroid disease 1 P01912,Q30154 330 7.55e-04 255 2 2 1.000 0.008 GO:0012506 CC 1 vesicle membrane 1 P01912,Q30154 330 8.07e-04 3 2 1 0.500 0.333 GO:0002399 BP 1 MHC class II protein complex assembly 1 P01912 330 8.66e-04 273 2 2 1.000 0.007 GO:0019221 BP 1 cytokine-mediated signaling pathway 1 P01912,Q30154 330 9.05e-04 279 2 2 1.000 0.007 GO:0044437 CC 1 vacuolar part 1 P01912,Q30154 330 9.20e-04 30 2 2 1.000 0.067 KEGG:05150 keg 1 Staphylococcus aureus infection 1 P01912,Q30154 330 9.44e-04 285 2 2 1.000 0.007 GO:0045321 BP 1 leukocyte activation 1 P01912,Q30154 330 1.04e-03 299 2 2 1.000 0.007 GO:0030155 BP 1 regulation of cell adhesion 1 P01912,Q30154 330 1.07e-03 303 2 2 1.000 0.007 GO:0002757 BP 1 immune response-activating signal transduction 1 P01912,Q30154 330 1.08e-03 4 2 1 0.500 0.250 GO:0002396 BP 1 MHC protein complex assembly 1 P01912 330 1.19e-03 34 2 2 1.000 0.059 KEGG:05321 keg 1 Inflammatory bowel disease (IBD) 1 P01912,Q30154 330 1.21e-03 322 2 2 1.000 0.006 GO:0002764 BP 1 immune response-regulating signaling pathway 1 P01912,Q30154 330 1.28e-03 332 2 2 1.000 0.006 GO:0000139 CC 1 Golgi membrane 1 P01912,Q30154 330 1.30e-03 334 2 2 1.000 0.006 GO:0016337 BP 1 single organismal cell-cell adhesion 1 P01912,Q30154 330 1.32e-03 337 2 2 1.000 0.006 GO:0002253 BP 1 activation of immune response 1 P01912,Q30154 330 1.35e-03 5 2 1 0.500 0.200 GO:2001179 BP 1 regulation of interleukin-10 secretion 1 P01912 330 1.35e-03 341 2 2 1.000 0.006 GO:0071345 BP 1 cellular response to cytokine stimulus 1 P01912,Q30154 330 1.36e-03 342 2 2 1.000 0.006 GO:0005764 CC 1 lysosome 1 P01912,Q30154 330 1.36e-03 342 2 2 1.000 0.006 GO:0000323 CC 1 lytic vacuole 1 P01912,Q30154 330 1.41e-03 37 2 2 1.000 0.054 KEGG:04640 keg 1 Hematopoietic cell lineage 1 P01912,Q30154 330 1.59e-03 370 2 2 1.000 0.005 GO:0098602 BP 1 single organism cell adhesion 1 P01912,Q30154 330 1.61e-03 6 2 1 0.500 0.167 GO:0072608 BP 1 interleukin-10 secretion 1 P01912 330 1.61e-03 6 2 1 0.500 0.167 GO:0002437 BP 1 inflammatory response to antigenic stimulus 1 P01912 330 1.61e-03 6 2 1 0.500 0.167 GO:0032395 MF 1 MHC class II receptor activity 1 P01912 330 1.61e-03 6 2 1 0.500 0.167 GO:0035774 BP 1 positive regulation of insulin secretion involved in cellular response to glucose stimulus 1 P01912 330 1.72e-03 385 2 2 1.000 0.005 GO:0001775 BP 1 cell activation 1 P01912,Q30154 330 1.74e-03 387 2 2 1.000 0.005 GO:0050778 BP 1 positive regulation of immune response 1 P01912,Q30154 330 1.76e-03 389 2 2 1.000 0.005 GO:0098609 BP 1 cell-cell adhesion 1 P01912,Q30154 330 1.79e-03 392 2 2 1.000 0.005 GO:0034097 BP 1 response to cytokine 1 P01912,Q30154 330 1.81e-03 394 2 2 1.000 0.005 GO:0005773 CC 1 vacuole 1 P01912,Q30154 330 1.88e-03 7 2 1 0.500 0.143 GO:0002455 BP 1 humoral immune response mediated by circulating immunoglobulin 1 P01912 330 1.99e-03 414 2 2 1.000 0.005 GO:0045087 BP 1 innate immune response 1 P01912,Q30154 330 2.00e-03 44 2 2 1.000 0.045 KEGG:05416 keg 1 Viral myocarditis 1 P01912,Q30154 330 2.09e-03 45 2 2 1.000 0.044 KEGG:04612 keg 1 Antigen processing and presentation 1 P01912,Q30154 330 2.15e-03 8 2 1 0.500 0.125 GO:0016045 BP 1 detection of bacterium 1 P01912 330 2.15e-03 8 2 1 0.500 0.125 GO:0032633 BP 1 interleukin-4 production 1 P01912 330 2.15e-03 8 2 1 0.500 0.125 GO:0032673 BP 1 regulation of interleukin-4 production 1 P01912 330 2.29e-03 444 2 2 1.000 0.005 GO:0098796 CC 1 membrane protein complex 1 P01912,Q30154 330 2.42e-03 9 2 1 0.500 0.111 GO:0098543 BP 1 detection of other organism 1 P01912 330 2.49e-03 49 2 2 1.000 0.041 KEGG:05140 keg 1 Leishmaniasis 1 P01912,Q30154 330 2.53e-03 466 2 2 1.000 0.004 GO:0005768 CC 1 endosome 1 P01912,Q30154 330 2.70e-03 51 2 2 1.000 0.039 KEGG:05323 keg 1 Rheumatoid arthritis 1 P01912,Q30154 330 2.70e-03 51 2 2 1.000 0.039 KEGG:05322 keg 1 Systemic lupus erythematosus 1 P01912,Q30154 330 2.70e-03 482 2 2 1.000 0.004 GO:0044431 CC 1 Golgi apparatus part 1 P01912,Q30154 330 2.90e-03 499 2 2 1.000 0.004 GO:0044433 CC 1 cytoplasmic vesicle part 1 P01912,Q30154 330 2.90e-03 499 2 2 1.000 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 P01912,Q30154 330 2.92e-03 501 2 2 1.000 0.004 GO:0050776 BP 1 regulation of immune response 1 P01912,Q30154 330 2.96e-03 11 2 1 0.500 0.091 GO:0042088 BP 1 T-helper 1 type immune response 1 P01912 330 2.96e-03 11 2 1 0.500 0.091 GO:0023026 MF 1 MHC class II protein complex binding 1 P01912 330 2.96e-03 11 2 1 0.500 0.091 GO:0023023 MF 1 MHC protein complex binding 1 P01912 330 3.23e-03 12 2 1 0.500 0.083 GO:0032689 BP 1 negative regulation of interferon-gamma production 1 P01912 330 3.23e-03 12 2 1 0.500 0.083 GO:0098581 BP 1 detection of external biotic stimulus 1 P01912 330 3.25e-03 528 2 2 1.000 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 P01912,Q30154 330 3.32e-03 534 2 2 1.000 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 P01912,Q30154 330 3.50e-03 13 2 1 0.500 0.077 GO:0042130 BP 1 negative regulation of T cell proliferation 1 P01912 330 3.76e-03 14 2 1 0.500 0.071 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 P01912 330 3.76e-03 14 2 1 0.500 0.071 GO:0032653 BP 1 regulation of interleukin-10 production 1 P01912 330 3.76e-03 14 2 1 0.500 0.071 GO:0061178 BP 1 regulation of insulin secretion involved in cellular response to glucose stimulus 1 P01912 330 4.03e-03 15 2 1 0.500 0.067 GO:0009595 BP 1 detection of biotic stimulus 1 P01912 330 4.03e-03 15 2 1 0.500 0.067 GO:0050672 BP 1 negative regulation of lymphocyte proliferation 1 P01912 330 4.03e-03 15 2 1 0.500 0.067 GO:0032945 BP 1 negative regulation of mononuclear cell proliferation 1 P01912 330 4.13e-03 63 2 2 1.000 0.032 KEGG:04658 keg 1 Th1 and Th2 cell differentiation 1 P01912,Q30154 330 4.30e-03 16 2 1 0.500 0.062 GO:0032613 BP 1 interleukin-10 production 1 P01912 330 4.57e-03 17 2 1 0.500 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 P01912 330 4.68e-03 446 2 2 1.000 0.004 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 P01912,Q30154 330 4.84e-03 18 2 1 0.500 0.056 GO:0032024 BP 1 positive regulation of insulin secretion 1 P01912 330 5.04e-03 658 2 2 1.000 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 P01912,Q30154 330 5.11e-03 19 2 1 0.500 0.053 GO:0035773 BP 1 insulin secretion involved in cellular response to glucose stimulus 1 P01912 330 5.17e-03 666 2 2 1.000 0.003 GO:0006952 BP 1 defense response 1 P01912,Q30154 330 5.35e-03 678 2 2 1.000 0.003 GO:0007155 BP 1 cell adhesion 1 P01912,Q30154 330 5.45e-03 684 2 2 1.000 0.003 GO:0022610 BP 1 biological adhesion 1 P01912,Q30154 330 5.54e-03 690 2 2 1.000 0.003 GO:0002682 BP 1 regulation of immune system process 1 P01912,Q30154 330 5.71e-03 74 2 2 1.000 0.027 KEGG:04514 keg 1 Cell adhesion molecules (CAMs) 1 P01912,Q30154 330 6.18e-03 23 2 1 0.500 0.043 GO:0016064 BP 1 immunoglobulin mediated immune response 1 P01912 330 6.18e-03 23 2 1 0.500 0.043 GO:0002793 BP 1 positive regulation of peptide secretion 1 P01912 330 6.18e-03 23 2 1 0.500 0.043 GO:0090277 BP 1 positive regulation of peptide hormone secretion 1 P01912 330 6.36e-03 739 2 2 1.000 0.003 GO:0006955 BP 1 immune response 1 P01912,Q30154 330 6.45e-03 24 2 1 0.500 0.042 GO:0019724 BP 1 B cell mediated immunity 1 P01912 330 6.71e-03 759 2 2 1.000 0.003 GO:0098805 CC 1 whole membrane 1 P01912,Q30154 330 6.72e-03 25 2 1 0.500 0.040 GO:0002377 BP 1 immunoglobulin production 1 P01912 330 6.72e-03 25 2 1 0.500 0.040 GO:0050868 BP 1 negative regulation of T cell activation 1 P01912 330 7.26e-03 27 2 1 0.500 0.037 GO:1903038 BP 1 negative regulation of leukocyte cell-cell adhesion 1 P01912 330 8.33e-03 31 2 1 0.500 0.032 GO:0071333 BP 1 cellular response to glucose stimulus 1 P01912 330 8.33e-03 31 2 1 0.500 0.032 GO:0046887 BP 1 positive regulation of hormone secretion 1 P01912 330 8.34e-03 846 2 2 1.000 0.002 GO:0005794 CC 1 Golgi apparatus 1 P01912,Q30154 330 8.87e-03 33 2 1 0.500 0.030 GO:0071331 BP 1 cellular response to hexose stimulus 1 P01912 330 8.87e-03 33 2 1 0.500 0.030 GO:0071326 BP 1 cellular response to monosaccharide stimulus 1 P01912 330 8.87e-03 33 2 1 0.500 0.030 GO:0051250 BP 1 negative regulation of lymphocyte activation 1 P01912 330 8.87e-03 614 2 2 1.000 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 P01912,Q30154 330 9.40e-03 35 2 1 0.500 0.029 GO:0032649 BP 1 regulation of interferon-gamma production 1 P01912 330 9.40e-03 35 2 1 0.500 0.029 GO:0071322 BP 1 cellular response to carbohydrate stimulus 1 P01912 330 9.44e-03 95 2 2 1.000 0.021 KEGG:05145 keg 1 Toxoplasmosis 1 P01912,Q30154 330 9.65e-03 910 2 2 1.000 0.002 GO:0097708 CC 1 intracellular vesicle 1 P01912,Q30154 330 9.94e-03 37 2 1 0.500 0.027 GO:0002695 BP 1 negative regulation of leukocyte activation 1 P01912 330 1.01e-02 931 2 2 1.000 0.002 GO:0031410 CC 1 cytoplasmic vesicle 1 P01912,Q30154 330 1.01e-02 933 2 2 1.000 0.002 GO:0005783 CC 1 endoplasmic reticulum 1 P01912,Q30154 330 1.04e-02 945 2 2 1.000 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 P01912,Q30154 330 1.05e-02 39 2 1 0.500 0.026 GO:0032609 BP 1 interferon-gamma production 1 P01912 330 1.15e-02 43 2 1 0.500 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 P01912 330 1.26e-02 47 2 1 0.500 0.021 GO:0042129 BP 1 regulation of T cell proliferation 1 P01912 330 1.29e-02 48 2 1 0.500 0.021 GO:0050866 BP 1 negative regulation of cell activation 1 P01912 330 1.34e-02 50 2 1 0.500 0.020 GO:0009749 BP 1 response to glucose 1 P01912 330 1.37e-02 51 2 1 0.500 0.020 GO:0022408 BP 1 negative regulation of cell-cell adhesion 1 P01912 330 1.37e-02 1086 2 2 1.000 0.002 GO:0048584 BP 1 positive regulation of response to stimulus 1 P01912,Q30154 330 1.42e-02 53 2 1 0.500 0.019 GO:0034284 BP 1 response to monosaccharide 1 P01912 330 1.42e-02 53 2 1 0.500 0.019 GO:0009746 BP 1 response to hexose 1 P01912 330 1.45e-02 54 2 1 0.500 0.019 GO:0042098 BP 1 T cell proliferation 1 P01912 330 1.50e-02 56 2 1 0.500 0.018 GO:0009743 BP 1 response to carbohydrate 1 P01912 330 1.56e-02 58 2 1 0.500 0.017 GO:0002440 BP 1 production of molecular mediator of immune response 1 P01912 330 1.56e-02 1157 2 2 1.000 0.002 GO:0071310 BP 1 cellular response to organic substance 1 P01912,Q30154 330 1.58e-02 1165 2 2 1.000 0.002 GO:0002376 BP 1 immune system process 1 P01912,Q30154 330 1.58e-02 59 2 1 0.500 0.017 GO:0050707 BP 1 regulation of cytokine secretion 1 P01912 330 1.61e-02 124 2 2 1.000 0.016 KEGG:04145 keg 1 Phagosome 1 P01912,Q30154 330 1.66e-02 62 2 1 0.500 0.016 GO:0050670 BP 1 regulation of lymphocyte proliferation 1 P01912 330 1.66e-02 62 2 1 0.500 0.016 GO:0032944 BP 1 regulation of mononuclear cell proliferation 1 P01912 330 1.70e-02 1408 2 2 1.000 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P01912,Q30154 330 1.72e-02 64 2 1 0.500 0.016 GO:0070663 BP 1 regulation of leukocyte proliferation 1 P01912 330 1.75e-02 129 2 2 1.000 0.016 KEGG:05164 keg 1 Influenza A 1 P01912,Q30154 330 1.77e-02 66 2 1 0.500 0.015 GO:0009897 CC 1 external side of plasma membrane 1 P01912 330 1.77e-02 130 2 2 1.000 0.015 KEGG:05152 keg 1 Tuberculosis 1 P01912,Q30154 330 1.88e-02 70 2 1 0.500 0.014 GO:0051262 BP 1 protein tetramerization 1 P01912 330 1.89e-02 1272 2 2 1.000 0.002 GO:0044459 CC 1 plasma membrane part 1 P01912,Q30154 330 1.90e-02 71 2 1 0.500 0.014 GO:0050663 BP 1 cytokine secretion 1 P01912 330 1.90e-02 71 2 1 0.500 0.014 GO:0050796 BP 1 regulation of insulin secretion 1 P01912 330 1.93e-02 72 2 1 0.500 0.014 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 P01912 330 1.94e-02 334 2 2 1.000 0.006 MI:hsa-miR-452* mi 1 MI:hsa-miR-452* 1 P01912,Q30154 330 2.04e-02 76 2 1 0.500 0.013 GO:0006959 BP 1 humoral immune response 1 P01912 330 2.06e-02 77 2 1 0.500 0.013 GO:0002449 BP 1 lymphocyte mediated immunity 1 P01912 330 2.08e-02 1559 2 2 1.000 0.001 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 P01912,Q30154 330 2.15e-02 80 2 1 0.500 0.013 GO:0032943 BP 1 mononuclear cell proliferation 1 P01912 330 2.15e-02 80 2 1 0.500 0.013 GO:0090276 BP 1 regulation of peptide hormone secretion 1 P01912 330 2.15e-02 80 2 1 0.500 0.013 GO:0046651 BP 1 lymphocyte proliferation 1 P01912 330 2.15e-02 80 2 1 0.500 0.013 GO:0042593 BP 1 glucose homeostasis 1 P01912 330 2.15e-02 80 2 1 0.500 0.013 GO:0033500 BP 1 carbohydrate homeostasis 1 P01912 330 2.17e-02 1589 2 2 1.000 0.001 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P01912,Q30154 330 2.17e-02 1589 2 2 1.000 0.001 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P01912,Q30154 330 2.17e-02 81 2 1 0.500 0.012 GO:0002791 BP 1 regulation of peptide secretion 1 P01912 330 2.20e-02 82 2 1 0.500 0.012 GO:0050714 BP 1 positive regulation of protein secretion 1 P01912 330 2.21e-02 145 2 2 1.000 0.014 KEGG:05168 keg 1 Herpes simplex infection 1 P01912,Q30154 330 2.23e-02 83 2 1 0.500 0.012 GO:0090087 BP 1 regulation of peptide transport 1 P01912 330 2.24e-02 359 2 2 1.000 0.006 MI:hsa-miR-125b-1* mi 1 MI:hsa-miR-125b-1* 1 P01912,Q30154 330 2.25e-02 84 2 1 0.500 0.012 GO:0030073 BP 1 insulin secretion 1 P01912 330 2.25e-02 84 2 1 0.500 0.012 GO:0070661 BP 1 leukocyte proliferation 1 P01912 330 2.26e-02 1392 2 2 1.000 0.001 GO:0016021 CC 1 integral component of membrane 1 P01912,Q30154 330 2.26e-02 1394 2 2 1.000 0.001 GO:0010033 BP 1 response to organic substance 1 P01912,Q30154 330 2.33e-02 1414 2 2 1.000 0.001 GO:0031090 CC 1 organelle membrane 1 P01912,Q30154 330 2.34e-02 1416 2 2 1.000 0.001 GO:0007166 BP 1 cell surface receptor signaling pathway 1 P01912,Q30154 330 2.36e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 P01912,Q30154 330 2.42e-02 1440 2 2 1.000 0.001 GO:0031224 CC 1 intrinsic component of membrane 1 P01912,Q30154 330 2.50e-02 1707 2 2 1.000 0.001 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P01912,Q30154 330 2.54e-02 382 2 2 1.000 0.005 MI:mmu-miR-764-3p mi 1 MI:mmu-miR-764-3p 1 P01912,Q30154 330 2.55e-02 95 2 1 0.500 0.011 GO:0002250 BP 1 adaptive immune response 1 P01912 330 2.57e-02 96 2 1 0.500 0.010 GO:0030072 BP 1 peptide hormone secretion 1 P01912 330 2.60e-02 97 2 1 0.500 0.010 GO:0046883 BP 1 regulation of hormone secretion 1 P01912 330 2.60e-02 97 2 1 0.500 0.010 GO:0002790 BP 1 peptide secretion 1 P01912 330 2.63e-02 389 2 2 1.000 0.005 MI:hsa-miR-920 mi 1 MI:hsa-miR-920 1 P01912,Q30154 330 2.65e-02 99 2 1 0.500 0.010 GO:0007162 BP 1 negative regulation of cell adhesion 1 P01912 330 2.67e-02 1765 2 2 1.000 0.001 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P01912,Q30154 330 2.71e-02 101 2 1 0.500 0.010 GO:0032846 BP 1 positive regulation of homeostatic process 1 P01912 330 2.73e-02 102 2 1 0.500 0.010 GO:0001818 BP 1 negative regulation of cytokine production 1 P01912 330 2.84e-02 106 2 1 0.500 0.009 GO:0015833 BP 1 peptide transport 1 P01912 330 2.87e-02 107 2 1 0.500 0.009 GO:0002443 BP 1 leukocyte mediated immunity 1 P01912 330 2.91e-02 409 2 2 1.000 0.005 MI:hsa-miR-708 mi 1 MI:hsa-miR-708 1 P01912,Q30154 330 3.03e-02 113 2 1 0.500 0.009 GO:0046879 BP 1 hormone secretion 1 P01912 330 3.11e-02 1904 2 2 1.000 0.001 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P01912,Q30154 330 3.13e-02 117 2 1 0.500 0.009 GO:0009914 BP 1 hormone transport 1 P01912 330 3.13e-02 117 2 1 0.500 0.009 GO:0042886 BP 1 amide transport 1 P01912 330 3.31e-02 436 2 2 1.000 0.005 MI:hsa-miR-143 mi 1 MI:hsa-miR-143 1 P01912,Q30154 330 3.31e-02 436 2 2 1.000 0.005 MI:hsa-miR-561 mi 1 MI:hsa-miR-561 1 P01912,Q30154 330 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P01912,Q30154 330 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P01912,Q30154 330 3.41e-02 180 2 2 1.000 0.011 KEGG:05169 keg 1 Epstein-Barr virus infection 1 P01912,Q30154 330 3.42e-02 128 2 1 0.500 0.008 GO:1903532 BP 1 positive regulation of secretion by cell 1 P01912 330 3.56e-02 133 2 1 0.500 0.008 GO:0002683 BP 1 negative regulation of immune system process 1 P01912 330 3.58e-02 134 2 1 0.500 0.007 GO:0051047 BP 1 positive regulation of secretion 1 P01912 330 3.75e-02 464 2 2 1.000 0.004 MI:hsa-miR-575 mi 1 MI:hsa-miR-575 1 P01912,Q30154 330 3.77e-02 141 2 1 0.500 0.007 GO:0051606 BP 1 detection of stimulus 1 P01912 330 3.93e-02 475 2 2 1.000 0.004 MI:hsa-miR-671-5p mi 1 MI:hsa-miR-671-5p 1 P01912,Q30154 330 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P01912,Q30154 330 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P01912,Q30154 330 4.12e-02 2191 2 2 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P01912,Q30154 330 4.13e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 P01912,Q30154 330 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P01912,Q30154 330 4.38e-02 164 2 1 0.500 0.006 GO:0009617 BP 1 response to bacterium 1 P01912 330 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P01912,Q30154 330 4.54e-02 170 2 1 0.500 0.006 GO:0050708 BP 1 regulation of protein secretion 1 P01912 330 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P01912,Q30154 330 4.60e-02 514 2 2 1.000 0.004 MI:hsa-miR-320 mi 1 MI:hsa-miR-320 1 P01912,Q30154 330 4.91e-02 184 2 1 0.500 0.005 GO:0023061 BP 1 signal release 1 P01912 330 5.00e-02 1 2 1 0.500 1.000 HP:0008940 hp 1 Generalized lymphadenopathy 1 P01912 330 5.00e-02 218 2 2 1.000 0.009 KEGG:05166 keg 1 HTLV-I infection 1 P01912,Q30154 330 5.00e-02 1457 2 2 1.000 0.001 REAC:168256 rea 1 Immune System 1 P01912,Q30154 330 5.00e-02 2071 2 2 1.000 0.001 GO:0006950 BP 1 response to stress 1 P01912,Q30154 330 5.00e-02 536 2 2 1.000 0.004 MI:mmu-miR-693-5p mi 1 MI:mmu-miR-693-5p 1 P01912,Q30154 330 5.00e-02 1 2 1 0.500 1.000 HP:0007734 hp 1 Enlarged lacrimal glands 1 P01912 330 5.00e-02 1 2 1 0.500 1.000 HP:0005397 hp 1 Exaggerated cellular immune processes 1 P01912 331 3.77e-03 12 4 1 0.250 0.083 TF:M00495_1 tf 1 Factor: Bach1; motif: NNSATGAGTCATGNT; match class: 1 1 O75695 331 3.77e-03 12 4 1 0.250 0.083 TF:M04213_1 tf 1 Factor: JDP2; motif: ATGACTCAT; match class: 1 1 O75695 331 4.71e-03 15 4 1 0.250 0.067 TF:M05764_0 tf 1 Factor: ZNF394; motif: KGGTGAARCAWM; match class: 0 1 Q8IWA5 331 5.45e-03 392 4 2 0.500 0.005 TF:M01036_1 tf 1 Factor: COUPTF; motif: NNNNNTGACCYTTGNMCNYNGMN; match class: 1 1 Q969Z3,Q92882 331 5.96e-03 19 4 1 0.250 0.053 TF:M06824_0 tf 1 Factor: Insm2; motif: MGAATTSCCYG; match class: 0 1 Q969Z3 331 7.52e-03 24 4 1 0.250 0.042 TF:M04174_1 tf 1 Factor: ID4; motif: NRCACCTGNN; match class: 1 1 Q92882 331 7.79e-03 3782 4 4 1.000 0.001 TF:M07300_1 tf 1 Factor: NF-1C; motif: TTGGCNN; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 8.34e-03 2 4 1 0.250 0.500 GO:0042126 BP 1 nitrate metabolic process 1 Q969Z3 331 8.34e-03 2 4 1 0.250 0.500 GO:0030151 MF 1 molybdenum ion binding 1 Q969Z3 331 8.34e-03 2 4 1 0.250 0.500 GO:0008940 MF 1 nitrate reductase activity 1 Q969Z3 331 8.96e-03 445 4 2 0.500 0.004 MI:hsa-miR-871 mi 1 MI:hsa-miR-871 1 Q969Z3,Q92882 331 9.93e-03 469 4 2 0.500 0.004 MI:mmu-miR-685 mi 1 MI:mmu-miR-685 1 Q969Z3,Q92882 331 1.06e-02 551 4 2 0.500 0.004 TF:M00776_0 tf 1 Factor: SREBP; motif: VNNVTCACCCYA; match class: 0 1 Q969Z3,Q92882 331 1.25e-02 3 4 1 0.250 0.333 GO:0016661 MF 1 oxidoreductase activity, acting on other nitrogenous compounds as donors 1 Q969Z3 331 1.25e-02 3 4 1 0.250 0.333 GO:0043546 MF 1 molybdopterin cofactor binding 1 Q969Z3 331 1.30e-02 1963 4 3 0.750 0.002 TF:M07256_0 tf 1 Factor: FXR:RXR; motif: RGGTCANTGACCTN; match class: 0 1 Q969Z3,Q8IWA5,Q92882 331 1.53e-02 49 4 1 0.250 0.020 TF:M03995_0 tf 1 Factor: SPIB; motif: NAAAAGMGGAAGTN; match class: 0 1 Q92882 331 1.57e-02 2194 4 4 1.000 0.002 GO:0070062 CC 1 extracellular exosome 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.60e-02 2205 4 4 1.000 0.002 GO:1903561 CC 1 extracellular vesicle 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.60e-02 2205 4 4 1.000 0.002 GO:0043230 CC 1 extracellular organelle 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.62e-02 52 4 1 0.250 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 Q92882 331 1.67e-02 4 4 1 0.250 0.250 GO:0015220 MF 1 choline transmembrane transporter activity 1 Q8IWA5 331 1.67e-02 4 4 1 0.250 0.250 GO:0015871 BP 1 choline transport 1 Q8IWA5 331 1.67e-02 2144 4 3 0.750 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 O75695,Q8IWA5,Q92882 331 1.75e-02 4627 4 4 1.000 0.001 TF:M07382_1 tf 1 Factor: Fli-1; motif: MGGAAGT; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.75e-02 4627 4 4 1.000 0.001 TF:M02278_1 tf 1 Factor: SPI1; motif: AGGAAGT; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.75e-02 4627 4 4 1.000 0.001 TF:M01870_1 tf 1 Factor: C-ets-1; motif: AGGAAGN; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.75e-02 4627 4 4 1.000 0.001 TF:M03579_1 tf 1 Factor: PEA3; motif: AGGAAGT; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 1.97e-02 63 4 1 0.250 0.016 TF:M06224_0 tf 1 Factor: ZNF415; motif: NGGGTGAAAMGA; match class: 0 1 O75695 331 2.01e-02 2288 4 3 0.750 0.001 TF:M00233_0 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 0 1 O75695,Q969Z3,Q8IWA5 331 2.09e-02 5 4 1 0.250 0.200 GO:0007023 BP 1 post-chaperonin tubulin folding pathway 1 O75695 331 2.09e-02 5 4 1 0.250 0.200 GO:0051410 BP 1 detoxification of nitrogen compound 1 Q969Z3 331 2.35e-02 834 4 2 0.500 0.002 TF:M06597_0 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 0 1 Q969Z3,Q92882 331 2.37e-02 76 4 1 0.250 0.013 TF:M01208_1 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 1 1 O75695 331 2.46e-02 79 4 1 0.250 0.013 TF:M01111_1 tf 1 Factor: RBP-Jkappa; motif: TTCCCACK; match class: 1 1 Q8IWA5 331 2.71e-02 5164 4 4 1.000 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 O75695,Q969Z3,Q8IWA5,Q92882 331 2.75e-02 904 4 2 0.500 0.002 TF:M01273_1 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 1 Q8IWA5,Q92882 331 2.94e-02 2618 4 3 0.750 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 O75695,Q969Z3,Q92882 331 3.13e-02 968 4 2 0.500 0.002 TF:M02271_1 tf 1 Factor: HOXA5; motif: CDBWAATK; match class: 1 1 O75695,Q969Z3 331 3.23e-02 2627 4 4 1.000 0.002 GO:0044421 CC 1 extracellular region part 1 O75695,Q969Z3,Q8IWA5,Q92882 331 3.35e-02 108 4 1 0.250 0.009 TF:M07049_1 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 1 1 Q92882 331 3.42e-02 1015 4 2 0.500 0.002 TF:M00339_1 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 1 Q8IWA5,Q92882 331 3.52e-02 1030 4 2 0.500 0.002 TF:M00123_0 tf 1 Factor: c-Myc:Max; motif: NANCACGTGNNW; match class: 0 1 Q969Z3,Q92882 331 3.54e-02 114 4 1 0.250 0.009 TF:M06757_0 tf 1 Factor: ZNF835; motif: TGGDCMTGCATC; match class: 0 1 Q969Z3 331 3.54e-02 114 4 1 0.250 0.009 TF:M04218_1 tf 1 Factor: MAFK; motif: NTGCTGANTCAGCRN; match class: 1 1 Q92882 331 3.60e-02 116 4 1 0.250 0.009 TF:M05781_0 tf 1 Factor: ZNF699; motif: NTGTCGGGCAGM; match class: 0 1 Q969Z3 331 3.67e-02 1054 4 2 0.500 0.002 TF:M00769_0 tf 1 Factor: AML; motif: NNGKNTGTGGTTWNC; match class: 0 1 Q8IWA5,Q92882 331 3.83e-02 2875 4 3 0.750 0.001 TF:M00007_0 tf 1 Factor: Elk-1; motif: NAAACMGGAAGTNCVH; match class: 0 1 O75695,Q8IWA5,Q92882 331 3.84e-02 2743 4 4 1.000 0.001 GO:0005576 CC 1 extracellular region 1 O75695,Q969Z3,Q8IWA5,Q92882 331 3.87e-02 5645 4 4 1.000 0.001 TF:M00351_0 tf 1 Factor: GATA-3; motif: ANAGATMWWA; match class: 0 1 O75695,Q969Z3,Q8IWA5,Q92882 331 4.14e-02 2795 4 4 1.000 0.001 GO:0031982 CC 1 vesicle 1 O75695,Q969Z3,Q8IWA5,Q92882 331 4.21e-02 2974 4 3 0.750 0.001 TF:M07129_1 tf 1 Factor: Sp2; motif: GYCCCGCCYCYNNNN; match class: 1 1 O75695,Q8IWA5,Q92882 331 4.30e-02 139 4 1 0.250 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q92882 331 4.33e-02 3006 4 3 0.750 0.001 TF:M03920_1 tf 1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 1 O75695,Q8IWA5,Q92882 331 4.39e-02 142 4 1 0.250 0.007 TF:M00938_1 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 1 Q92882 331 4.54e-02 147 4 1 0.250 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 O75695 331 4.62e-02 1191 4 2 0.500 0.002 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q969Z3,Q8IWA5 331 4.63e-02 1193 4 2 0.500 0.002 TF:M00998_0 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 0 1 Q8IWA5,Q92882 331 4.81e-02 3121 4 3 0.750 0.001 TF:M00701_1 tf 1 Factor: SMAD3; motif: TGTCTGTCT; match class: 1 1 O75695,Q969Z3,Q92882 331 5.00e-02 4 4 1 0.250 0.250 REAC:5624138 rea 1 Trafficking of myristoylated proteins to the cilium 1 O75695 331 5.00e-02 12 4 1 0.250 0.083 GO:0008519 MF 1 ammonium transmembrane transporter activity 1 Q8IWA5 331 5.00e-02 1 4 1 0.250 1.000 OMIM:312600 omi 1 RETINITIS PIGMENTOSA 2; RP2 1 O75695 331 5.00e-02 3 4 1 0.250 0.333 CORUM:5713 cor 1 SH3P2/OSTF1-CBL-SRC complex 1 Q92882 332 1.88e-03 12 2 1 0.500 0.083 TF:M03865_1 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 1 1 Q9NYY3 332 2.09e-03 3 2 1 0.500 0.333 GO:0043008 MF 1 ATP-dependent protein binding 1 Q9NYY3 332 3.48e-03 5 2 1 0.500 0.200 GO:0060292 BP 1 long term synaptic depression 1 Q9NYY3 332 7.06e-03 45 2 1 0.500 0.022 TF:M00228_1 tf 1 Factor: VBP; motif: GTTACRTMAT; match class: 1 1 Q9NYY3 332 7.66e-03 11 2 1 0.500 0.091 GO:0060291 BP 1 long-term synaptic potentiation 1 Q9NYY3 332 7.66e-03 11 2 1 0.500 0.091 GO:0032486 BP 1 Rap protein signal transduction 1 Q9NYY3 332 8.94e-03 57 2 1 0.500 0.018 TF:M04225_1 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 1 1 Q9NYY3 332 9.75e-03 14 2 1 0.500 0.071 GO:0046599 BP 1 regulation of centriole replication 1 Q9NYY3 332 1.21e-02 77 2 1 0.500 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 Q9NYY3 332 1.25e-02 18 2 1 0.500 0.056 GO:0050805 BP 1 negative regulation of synaptic transmission 1 Q9NYY3 332 1.28e-02 1220 2 2 1.000 0.002 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 1.46e-02 93 2 1 0.500 0.011 TF:M00260_1 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 1 1 Q9NYY3 332 1.61e-02 103 2 1 0.500 0.010 TF:M01279_1 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 1 Q9NYY3 332 1.67e-02 107 2 1 0.500 0.009 TF:M00241_1 tf 1 Factor: Nkx2-5; motif: CWTAATTG; match class: 1 1 Q9NYY3 332 1.74e-02 25 2 1 0.500 0.040 GO:0007613 BP 1 memory 1 Q9NYY3 332 1.78e-02 1440 2 2 1.000 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 1.78e-02 114 2 1 0.500 0.009 TF:M07314_1 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 1 1 Q9NYY3 332 1.88e-02 27 2 1 0.500 0.037 GO:0007099 BP 1 centriole replication 1 Q9NYY3 332 1.90e-02 1488 2 2 1.000 0.001 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 1.92e-02 123 2 1 0.500 0.008 TF:M05313_1 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 1 1 Q9NYY3 332 1.95e-02 28 2 1 0.500 0.036 GO:0098534 BP 1 centriole assembly 1 Q9NYY3 332 2.02e-02 29 2 1 0.500 0.034 GO:0010824 BP 1 regulation of centrosome duplication 1 Q9NYY3 332 2.11e-02 135 2 1 0.500 0.007 TF:M07101_0 tf 1 Factor: c-Jun; motif: NNRATGATGTCAT; match class: 0 1 Q9NYY3 332 2.11e-02 19 2 1 0.500 0.053 REAC:6804115 rea 1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 1 Q9NYY3 332 2.14e-02 137 2 1 0.500 0.007 TF:M06482_0 tf 1 Factor: ZNF547; motif: KGTTCCTGGMGA; match class: 0 1 Q9NYY3 332 2.30e-02 33 2 1 0.500 0.030 GO:0050806 BP 1 positive regulation of synaptic transmission 1 Q9NYY3 332 2.31e-02 148 2 1 0.500 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 Q9NYY3 332 2.43e-02 35 2 1 0.500 0.029 GO:0046605 BP 1 regulation of centrosome cycle 1 Q9NYY3 332 2.93e-02 188 2 1 0.500 0.005 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 Q9NYY3 332 2.99e-02 43 2 1 0.500 0.023 GO:0048167 BP 1 regulation of synaptic plasticity 1 Q9NYY3 332 3.16e-02 203 2 1 0.500 0.005 TF:M01233_1 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 1 1 Q9NYY3 332 3.29e-02 211 2 1 0.500 0.005 TF:M03938_0 tf 1 Factor: ZNF524; motif: CTCGAACCCKTGNN; match class: 0 1 Q9NYY3 332 3.38e-02 1984 2 2 1.000 0.001 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 3.68e-02 53 2 1 0.500 0.019 GO:0006977 BP 1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1 Q9NYY3 332 3.75e-02 54 2 1 0.500 0.019 GO:0072431 BP 1 signal transduction involved in mitotic G1 DNA damage checkpoint 1 Q9NYY3 332 3.75e-02 54 2 1 0.500 0.019 GO:1902400 BP 1 intracellular signal transduction involved in G1 DNA damage checkpoint 1 Q9NYY3 332 3.75e-02 54 2 1 0.500 0.019 GO:0051298 BP 1 centrosome duplication 1 Q9NYY3 332 3.82e-02 55 2 1 0.500 0.018 GO:0072413 BP 1 signal transduction involved in mitotic cell cycle checkpoint 1 Q9NYY3 332 3.82e-02 55 2 1 0.500 0.018 GO:1902402 BP 1 signal transduction involved in mitotic DNA damage checkpoint 1 Q9NYY3 332 3.82e-02 55 2 1 0.500 0.018 GO:1902403 BP 1 signal transduction involved in mitotic DNA integrity checkpoint 1 Q9NYY3 332 3.87e-02 249 2 1 0.500 0.004 TF:M07105_0 tf 1 Factor: JunD; motif: NNNRATGAYGTCATN; match class: 0 1 Q9NYY3 332 3.96e-02 57 2 1 0.500 0.018 GO:0072422 BP 1 signal transduction involved in DNA damage checkpoint 1 Q9NYY3 332 3.96e-02 57 2 1 0.500 0.018 GO:0072395 BP 1 signal transduction involved in cell cycle checkpoint 1 Q9NYY3 332 3.96e-02 57 2 1 0.500 0.018 GO:0072401 BP 1 signal transduction involved in DNA integrity checkpoint 1 Q9NYY3 332 4.03e-02 58 2 1 0.500 0.017 GO:0007611 BP 1 learning or memory 1 Q9NYY3 332 4.17e-02 60 2 1 0.500 0.017 GO:0010508 BP 1 positive regulation of autophagy 1 Q9NYY3 332 4.17e-02 60 2 1 0.500 0.017 GO:0031571 BP 1 mitotic G1 DNA damage checkpoint 1 Q9NYY3 332 4.17e-02 60 2 1 0.500 0.017 GO:0044819 BP 1 mitotic G1/S transition checkpoint 1 Q9NYY3 332 4.24e-02 61 2 1 0.500 0.016 GO:0044783 BP 1 G1 DNA damage checkpoint 1 Q9NYY3 332 4.43e-02 285 2 1 0.500 0.004 TF:M03822_0 tf 1 Factor: FoxH1; motif: SAATACACAT; match class: 0 1 Q9NYY3 332 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 4.52e-02 291 2 1 0.500 0.003 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 Q9NYY3 332 4.54e-02 292 2 1 0.500 0.003 TF:M07138_0 tf 1 Factor: p63; motif: NNRCAWGYNCARRCWTGYNN; match class: 0 1 Q9NYY3 332 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q9NYY3 332 4.58e-02 295 2 1 0.500 0.003 TF:M04504_1 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 1 1 Q9NYY3 332 4.58e-02 295 2 1 0.500 0.003 TF:M04211_1 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 1 1 Q9NYY3 332 4.58e-02 295 2 1 0.500 0.003 TF:M04504_0 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 0 1 Q9NYY3 332 4.58e-02 295 2 1 0.500 0.003 TF:M04211_0 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 0 1 Q9NYY3 332 4.65e-02 67 2 1 0.500 0.015 GO:0007098 BP 1 centrosome cycle 1 Q9NYY3 332 4.66e-02 300 2 1 0.500 0.003 TF:M04112_1 tf 1 Factor: GMEB2; motif: TTACGYAM; match class: 1 1 Q9NYY3 332 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q9NYY3,Q3YEC7 332 4.79e-02 69 2 1 0.500 0.014 GO:0071158 BP 1 positive regulation of cell cycle arrest 1 Q9NYY3 332 4.86e-02 313 2 1 0.500 0.003 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 Q9NYY3 332 5.00e-02 72 2 1 0.500 0.014 GO:0005814 CC 1 centriole 1 Q9NYY3 332 5.00e-02 45 2 1 0.500 0.022 REAC:6791312 rea 1 TP53 Regulates Transcription of Cell Cycle Genes 1 Q9NYY3 332 5.00e-02 111 2 1 0.500 0.009 KEGG:04068 keg 1 FoxO signaling pathway 1 Q9NYY3 332 5.00e-02 379 2 2 1.000 0.005 MI:mmu-miR-343 mi 1 MI:mmu-miR-343 1 Q9NYY3,Q3YEC7 333 3.27e-03 3 2 1 0.500 0.333 GO:0070004 MF 1 cysteine-type exopeptidase activity 1 Q9H8M7 333 3.27e-03 3 2 1 0.500 0.333 GO:0016807 MF 1 cysteine-type carboxypeptidase activity 1 Q9H8M7 333 3.64e-03 652 2 2 1.000 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q9H8M7,Q9UPN6 333 7.08e-03 909 2 2 1.000 0.002 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 Q9H8M7,Q9UPN6 333 7.62e-03 7 2 1 0.500 0.143 GO:1990380 MF 1 Lys48-specific deubiquitinase activity 1 Q9H8M7 333 2.14e-02 1578 2 2 1.000 0.001 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 Q9H8M7,Q9UPN6 333 2.71e-02 147 2 1 0.500 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q9UPN6 333 2.72e-02 25 2 1 0.500 0.040 GO:0043175 MF 1 RNA polymerase core enzyme binding 1 Q9UPN6 333 3.53e-02 2029 2 2 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 Q9H8M7,Q9UPN6 333 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q9UPN6 333 3.76e-02 205 2 1 0.500 0.005 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 Q9UPN6 333 3.81e-02 35 2 1 0.500 0.029 GO:0004180 MF 1 carboxypeptidase activity 1 Q9H8M7 333 4.05e-02 221 2 1 0.500 0.005 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 Q9UPN6 333 4.13e-02 38 2 1 0.500 0.026 GO:0070063 MF 1 RNA polymerase binding 1 Q9UPN6 333 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q9UPN6 333 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q9H8M7,Q9UPN6 333 4.85e-02 265 2 1 0.500 0.004 HPA:018010_13 hpa 1 hippocampus; glial cells[Supportive,High] 1 Q9UPN6 333 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q9H8M7,Q9UPN6 333 5.00e-02 291 2 2 1.000 0.007 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 Q9H8M7,Q9UPN6 333 5.00e-02 458 2 2 1.000 0.004 MI:hsa-miR-223 mi 1 MI:hsa-miR-223 1 Q9H8M7,Q9UPN6 333 5.00e-02 29 2 1 0.500 0.034 CORUM:1183 cor 1 CDC5L complex 1 Q9UPN6 333 5.00e-02 46 2 1 0.500 0.022 GO:0016363 CC 1 nuclear matrix 1 Q9UPN6 334 5.21e-07 4 2 2 1.000 0.500 GO:0072487 CC 1 MSL complex 1 Q9H7Z6,Q9HCI7 334 5.05e-06 4 2 2 1.000 0.500 CORUM:610 cor 1 MSL complex 1 Q9H7Z6,Q9HCI7 334 2.40e-05 24 2 2 1.000 0.083 GO:0043984 BP 1 histone H4-K16 acetylation 1 Q9H7Z6,Q9HCI7 334 6.11e-05 38 2 2 1.000 0.053 GO:1902562 CC 1 H4 histone acetyltransferase complex 1 Q9H7Z6,Q9HCI7 334 1.20e-04 53 2 2 1.000 0.038 GO:0043967 BP 1 histone H4 acetylation 1 Q9H7Z6,Q9HCI7 334 2.82e-04 81 2 2 1.000 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q9H7Z6,Q9HCI7 334 3.56e-04 91 2 2 1.000 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q9H7Z6,Q9HCI7 334 3.56e-04 91 2 2 1.000 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q9H7Z6,Q9HCI7 334 4.56e-04 103 2 2 1.000 0.019 GO:0016573 BP 1 histone acetylation 1 Q9H7Z6,Q9HCI7 334 4.74e-04 105 2 2 1.000 0.019 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q9H7Z6,Q9HCI7 334 4.93e-04 107 2 2 1.000 0.019 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q9H7Z6,Q9HCI7 334 5.21e-04 110 2 2 1.000 0.018 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q9H7Z6,Q9HCI7 334 6.95e-04 127 2 2 1.000 0.016 GO:0006473 BP 1 protein acetylation 1 Q9H7Z6,Q9HCI7 334 9.45e-04 148 2 2 1.000 0.014 GO:0043543 BP 1 protein acylation 1 Q9H7Z6,Q9HCI7 334 3.42e-03 281 2 2 1.000 0.007 GO:0016570 BP 1 histone modification 1 Q9H7Z6,Q9HCI7 334 3.64e-03 290 2 2 1.000 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q9H7Z6,Q9HCI7 334 3.79e-03 296 2 2 1.000 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9H7Z6,Q9HCI7 334 3.87e-03 2 2 1 0.500 0.500 CORUM:724 cor 1 MAF2 complex 1 Q9H7Z6 334 5.18e-03 33 2 1 0.500 0.030 TF:M06619_0 tf 1 Factor: ZNF669; motif: KGGGTCGGCGGA; match class: 0 1 Q9H7Z6 334 5.18e-03 33 2 1 0.500 0.030 TF:M06093_0 tf 1 Factor: ZNF17; motif: KGGTCCAASRTT; match class: 0 1 Q9HCI7 334 8.74e-03 449 2 2 1.000 0.004 GO:0006325 BP 1 chromatin organization 1 Q9H7Z6,Q9HCI7 334 9.65e-03 93 2 2 1.000 0.022 REAC:3214847 rea 1 HATs acetylate histones 1 Q9H7Z6,Q9HCI7 334 9.72e-03 62 2 1 0.500 0.016 TF:M00652_1 tf 1 Factor: NRF-1; motif: CGCATGCGCR; match class: 1 1 Q9HCI7 334 1.00e-02 10 2 1 0.500 0.100 GO:0043995 MF 1 histone acetyltransferase activity (H4-K5 specific) 1 Q9H7Z6 334 1.00e-02 10 2 1 0.500 0.100 GO:0046972 MF 1 histone acetyltransferase activity (H4-K16 specific) 1 Q9H7Z6 334 1.00e-02 10 2 1 0.500 0.100 GO:0043996 MF 1 histone acetyltransferase activity (H4-K8 specific) 1 Q9H7Z6 334 1.00e-02 64 2 1 0.500 0.016 TF:M05591_0 tf 1 Factor: ZNF215; motif: GAGWATGCGGM; match class: 0 1 Q9H7Z6 334 1.10e-02 1333 2 2 1.000 0.002 TF:M07372_0 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 0 1 Q9H7Z6,Q9HCI7 334 1.18e-02 521 2 2 1.000 0.004 GO:0044451 CC 1 nucleoplasm part 1 Q9H7Z6,Q9HCI7 334 1.47e-02 94 2 1 0.500 0.011 TF:M06523_0 tf 1 Factor: ZNF527; motif: KGGAGWATGCGM; match class: 0 1 Q9H7Z6 334 1.50e-02 15 2 1 0.500 0.067 GO:0043981 BP 1 histone H4-K5 acetylation 1 Q9H7Z6 334 1.50e-02 15 2 1 0.500 0.067 GO:0043982 BP 1 histone H4-K8 acetylation 1 Q9H7Z6 334 1.60e-02 16 2 1 0.500 0.062 GO:0010485 MF 1 H4 histone acetyltransferase activity 1 Q9H7Z6 334 1.64e-02 105 2 1 0.500 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 Q9H7Z6 334 1.69e-02 624 2 2 1.000 0.003 GO:1990234 CC 1 transferase complex 1 Q9H7Z6,Q9HCI7 334 1.78e-02 1700 2 2 1.000 0.001 TF:M07397_0 tf 1 Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 0 1 Q9H7Z6,Q9HCI7 334 1.93e-02 10 2 1 0.500 0.100 CORUM:1401 cor 1 MOF complex 1 Q9H7Z6 334 2.25e-02 720 2 2 1.000 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9H7Z6,Q9HCI7 334 2.27e-02 1916 2 2 1.000 0.001 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 Q9H7Z6,Q9HCI7 334 2.44e-02 1989 2 2 1.000 0.001 TF:M07208_1 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 1 Q9H7Z6,Q9HCI7 334 2.61e-02 2057 2 2 1.000 0.001 TF:M00482_0 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 0 1 Q9H7Z6,Q9HCI7 334 2.64e-02 2070 2 2 1.000 0.001 TF:M05961_0 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 0 1 Q9H7Z6,Q9HCI7 334 2.70e-02 27 2 1 0.500 0.037 GO:0071339 CC 1 MLL1 complex 1 Q9H7Z6 334 2.70e-02 27 2 1 0.500 0.037 GO:0044665 CC 1 MLL1/2 complex 1 Q9H7Z6 334 2.78e-02 178 2 1 0.500 0.006 TF:M00411_1 tf 1 Factor: HNF4alpha1; motif: NRGGNCAAAGGTCAN; match class: 1 1 Q9HCI7 334 2.87e-02 184 2 1 0.500 0.005 TF:M05417_0 tf 1 Factor: ZNF641; motif: NAGGGGKGGGGN; match class: 0 1 Q9H7Z6 334 3.03e-02 194 2 1 0.500 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 Q9H7Z6 334 3.27e-02 210 2 1 0.500 0.005 TF:M00976_1 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 1 Q9HCI7 334 3.77e-02 242 2 1 0.500 0.004 TF:M05961_1 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 1 1 Q9HCI7 334 4.07e-02 262 2 1 0.500 0.004 TF:M06887_1 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 1 1 Q9HCI7 334 4.20e-02 42 2 1 0.500 0.024 GO:0035064 MF 1 methylated histone binding 1 Q9H7Z6 334 4.59e-02 2727 2 2 1.000 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 Q9H7Z6,Q9HCI7 334 4.63e-02 1033 2 2 1.000 0.002 GO:1902494 CC 1 catalytic complex 1 Q9H7Z6,Q9HCI7 334 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q9H7Z6,Q9HCI7 334 4.88e-02 2813 2 2 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 Q9H7Z6,Q9HCI7 334 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q9H7Z6,Q9HCI7 334 5.00e-02 211 2 2 1.000 0.009 REAC:4839726 rea 1 Chromatin organization 1 Q9H7Z6,Q9HCI7 334 5.00e-02 50 2 1 0.500 0.020 GO:0004402 MF 1 histone acetyltransferase activity 1 Q9H7Z6 334 5.00e-02 211 2 2 1.000 0.009 REAC:3247509 rea 1 Chromatin modifying enzymes 1 Q9H7Z6,Q9HCI7 334 5.00e-02 26 2 1 0.500 0.038 CORUM:5386 cor 1 MLL1-WDR5 complex 1 Q9H7Z6 335 1.56e-07 4 2 2 1.000 0.500 GO:1902857 BP 1 positive regulation of non-motile cilium assembly 1 Q9P2S5,Q66GS9 335 2.60e-07 5 2 2 1.000 0.400 GO:1902855 BP 1 regulation of non-motile cilium assembly 1 Q9P2S5,Q66GS9 335 2.03e-06 13 2 2 1.000 0.154 GO:0045724 BP 1 positive regulation of cilium assembly 1 Q9P2S5,Q66GS9 335 5.47e-06 21 2 2 1.000 0.095 GO:1905515 BP 1 non-motile cilium assembly 1 Q9P2S5,Q66GS9 335 1.83e-05 38 2 2 1.000 0.053 GO:1902117 BP 1 positive regulation of organelle assembly 1 Q9P2S5,Q66GS9 335 2.94e-05 48 2 2 1.000 0.042 GO:1902017 BP 1 regulation of cilium assembly 1 Q9P2S5,Q66GS9 335 1.50e-04 108 2 2 1.000 0.019 GO:0060491 BP 1 regulation of cell projection assembly 1 Q9P2S5,Q66GS9 335 2.18e-04 130 2 2 1.000 0.015 GO:1902115 BP 1 regulation of organelle assembly 1 Q9P2S5,Q66GS9 335 2.61e-04 142 2 2 1.000 0.014 GO:0044782 BP 1 cilium organization 1 Q9P2S5,Q66GS9 335 2.83e-04 148 2 2 1.000 0.014 GO:0031346 BP 1 positive regulation of cell projection organization 1 Q9P2S5,Q66GS9 335 5.50e-04 206 2 2 1.000 0.010 GO:0060271 BP 1 cilium assembly 1 Q9P2S5,Q66GS9 335 7.35e-04 238 2 2 1.000 0.008 GO:0030031 BP 1 cell projection assembly 1 Q9P2S5,Q66GS9 335 9.04e-04 264 2 2 1.000 0.008 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 Q9P2S5,Q66GS9 335 1.20e-03 304 2 2 1.000 0.007 GO:0031344 BP 1 regulation of cell projection organization 1 Q9P2S5,Q66GS9 335 1.41e-03 330 2 2 1.000 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q9P2S5,Q66GS9 335 1.68e-03 360 2 2 1.000 0.006 GO:0010638 BP 1 positive regulation of organelle organization 1 Q9P2S5,Q66GS9 335 2.17e-03 409 2 2 1.000 0.005 GO:0005813 CC 1 centrosome 1 Q9P2S5,Q66GS9 335 2.57e-03 445 2 2 1.000 0.004 GO:0070925 BP 1 organelle assembly 1 Q9P2S5,Q66GS9 335 2.74e-03 459 2 2 1.000 0.004 GO:0007017 BP 1 microtubule-based process 1 Q9P2S5,Q66GS9 335 2.92e-03 474 2 2 1.000 0.004 GO:0005815 CC 1 microtubule organizing center 1 Q9P2S5,Q66GS9 335 3.00e-03 10 2 1 0.500 0.100 GO:0010457 BP 1 centriole-centriole cohesion 1 Q66GS9 335 3.30e-03 504 2 2 1.000 0.004 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q9P2S5,Q66GS9 335 3.34e-03 1 2 1 0.500 1.000 OMIM:614673 omi 1 MICROCEPHALY 8, PRIMARY, AUTOSOMAL RECESSIVE; MCPH8 1 Q66GS9 335 5.49e-03 650 2 2 1.000 0.003 GO:0030030 BP 1 cell projection organization 1 Q9P2S5,Q66GS9 335 5.61e-03 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q9P2S5,Q66GS9 335 6.50e-03 707 2 2 1.000 0.003 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q9P2S5,Q66GS9 335 6.50e-03 707 2 2 1.000 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q9P2S5,Q66GS9 335 6.76e-03 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q9P2S5,Q66GS9 335 7.47e-03 758 2 2 1.000 0.003 GO:0007010 BP 1 cytoskeleton organization 1 Q9P2S5,Q66GS9 335 7.69e-03 769 2 2 1.000 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 Q9P2S5,Q66GS9 335 8.10e-03 27 2 1 0.500 0.037 GO:0007099 BP 1 centriole replication 1 Q66GS9 335 8.40e-03 28 2 1 0.500 0.036 GO:0098534 BP 1 centriole assembly 1 Q66GS9 335 1.13e-02 933 2 2 1.000 0.002 GO:0044430 CC 1 cytoskeletal part 1 Q9P2S5,Q66GS9 335 1.18e-02 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 Q9P2S5,Q66GS9 335 1.59e-02 53 2 1 0.500 0.019 GO:0090307 BP 1 mitotic spindle assembly 1 Q9P2S5 335 1.62e-02 54 2 1 0.500 0.019 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 Q9P2S5 335 1.62e-02 54 2 1 0.500 0.019 GO:0051298 BP 1 centrosome duplication 1 Q66GS9 335 1.66e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 Q9P2S5,Q66GS9 335 1.77e-02 1168 2 2 1.000 0.002 GO:1902589 BP 1 single-organism organelle organization 1 Q9P2S5,Q66GS9 335 1.89e-02 1204 2 2 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 Q9P2S5,Q66GS9 335 1.89e-02 63 2 1 0.500 0.016 GO:0036064 CC 1 ciliary basal body 1 Q9P2S5 335 2.01e-02 67 2 1 0.500 0.015 GO:0007098 BP 1 centrosome cycle 1 Q66GS9 335 2.14e-02 3 2 1 0.500 0.333 TF:M04455_0 tf 1 Factor: ESR1; motif: NRGGTCACNRTGACCTK; match class: 0 1 Q66GS9 335 2.16e-02 72 2 1 0.500 0.014 GO:0005814 CC 1 centriole 1 Q66GS9 335 2.28e-02 76 2 1 0.500 0.013 GO:0051225 BP 1 spindle assembly 1 Q9P2S5 335 2.63e-02 88 2 1 0.500 0.011 GO:0007052 BP 1 mitotic spindle organization 1 Q9P2S5 335 2.69e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 Q9P2S5,Q66GS9 335 2.90e-02 97 2 1 0.500 0.010 GO:0051297 BP 1 centrosome organization 1 Q66GS9 335 3.17e-02 106 2 1 0.500 0.009 GO:0031023 BP 1 microtubule organizing center organization 1 Q66GS9 335 3.23e-02 108 2 1 0.500 0.009 GO:0008022 MF 1 protein C-terminus binding 1 Q66GS9 335 3.41e-02 114 2 1 0.500 0.009 GO:0044450 CC 1 microtubule organizing center part 1 Q66GS9 335 3.59e-02 66 2 1 0.500 0.015 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 Q66GS9 335 3.59e-02 66 2 1 0.500 0.015 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 Q66GS9 335 3.68e-02 123 2 1 0.500 0.008 GO:0007051 BP 1 spindle organization 1 Q9P2S5 335 3.76e-02 69 2 1 0.500 0.014 REAC:8854518 rea 1 AURKA Activation by TPX2 1 Q66GS9 335 3.79e-02 1706 2 2 1.000 0.001 GO:0022607 BP 1 cellular component assembly 1 Q9P2S5,Q66GS9 335 4.08e-02 75 2 1 0.500 0.013 REAC:380270 rea 1 Recruitment of mitotic centrosome proteins and complexes 1 Q66GS9 335 4.08e-02 75 2 1 0.500 0.013 REAC:380287 rea 1 Centrosome maturation 1 Q66GS9 335 4.12e-02 14 2 1 0.500 0.071 HP:0011019 hp 1 Abnormality of chromosome condensation 1 Q66GS9 335 4.12e-02 14 2 1 0.500 0.071 HP:0002472 hp 1 Small cerebral cortex 1 Q66GS9 335 4.12e-02 14 2 1 0.500 0.071 HP:0003451 hp 1 Increased rate of premature chromosome condensation 1 Q66GS9 335 4.51e-02 83 2 1 0.500 0.012 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 Q66GS9 335 4.60e-02 154 2 1 0.500 0.006 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 Q66GS9 335 4.78e-02 271 2 1 0.500 0.004 MI:hsa-miR-526b* mi 1 MI:hsa-miR-526b* 1 Q9P2S5 335 4.80e-02 161 2 1 0.500 0.006 GO:0044839 BP 1 cell cycle G2/M phase transition 1 Q66GS9 335 4.86e-02 1932 2 2 1.000 0.001 GO:0044085 BP 1 cellular component biogenesis 1 Q9P2S5,Q66GS9 335 5.00e-02 1960 2 2 1.000 0.001 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9P2S5,Q66GS9 335 5.00e-02 1960 2 2 1.000 0.001 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9P2S5,Q66GS9 335 5.00e-02 92 2 1 0.500 0.011 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 Q66GS9 335 5.00e-02 17 2 1 0.500 0.059 HP:0010636 hp 1 Schizencephaly 1 Q66GS9 335 5.00e-02 7 2 1 0.500 0.143 TF:M04519_1 tf 1 Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 1 1 Q9P2S5 336 9.43e-04 3 4 1 0.250 0.333 TF:M06140_0 tf 1 Factor: ZNF647; motif: GKGGGGGACYGAGGYGGC; match class: 0 1 Q7L7X3 336 3.91e-03 3184 4 4 1.000 0.001 TF:M01798_0 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 4.19e-03 1 4 1 0.250 1.000 OMIM:613091 omi 1 SHORT-RIB THORACIC DYSPLASIA 3 WITH OR WITHOUT POLYDACTYLY; SRTD3;;ASPHYXIATING THORACIC DYSTROPHY 3; ATD3;;SHORT RIB-POLYDACTYLY SYNDROME, TYPE I; SRPS1;;SALDINO-NOONAN SYNDROME;;POLYDACTYLY WITH NEONATAL CHONDRODYSTROPHY, TYPE I;;SHORT RIB-POLYDACTYLY SYNDROME, TYPE III; SRPS3;;VERMA-NAUMOFF SYNDROME;;POLYDACTYLY WITH NEONATAL CHONDRODYSTROPHY, TYPE III;;SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIB; SRPS2B 1 Q8NCM8 336 5.33e-03 17 4 1 0.250 0.059 TF:M06386_0 tf 1 Factor: ZNF836; motif: NGGTGAAGCCAG; match class: 0 1 Q7L7X3 336 5.61e-03 2 4 1 0.250 0.500 HP:0005873 hp 1 Polysyndactyly of hallux 1 Q8NCM8 336 5.61e-03 2 4 1 0.250 0.500 HP:0005817 hp 1 Postaxial polysyndactyly of foot 1 Q8NCM8 336 5.61e-03 2 4 1 0.250 0.500 HP:0005766 hp 1 Disproportionate shortening of the tibia 1 Q8NCM8 336 6.24e-03 1524 4 3 0.750 0.002 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q7L7X3,Q8NCM8,O60231 336 7.03e-03 393 4 2 0.500 0.005 MI:hsa-miR-597 mi 1 MI:hsa-miR-597 1 Q8N1G4,Q8NCM8 336 7.52e-03 24 4 1 0.250 0.042 TF:M05972_0 tf 1 Factor: ZNF701; motif: NTGGGGTGAARA; match class: 0 1 Q7L7X3 336 7.59e-03 394 4 2 0.500 0.005 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 Q8NCM8,O60231 336 7.71e-03 412 4 2 0.500 0.005 MI:hsa-miR-889 mi 1 MI:hsa-miR-889 1 Q7L7X3,Q8NCM8 336 8.53e-03 1440 4 3 0.750 0.002 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q8N1G4,Q8NCM8,O60231 336 9.25e-03 1746 4 3 0.750 0.002 TF:M00006_0 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 0 1 Q7L7X3,Q8NCM8,O60231 336 9.54e-03 1765 4 3 0.750 0.002 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q7L7X3,Q8NCM8,O60231 336 9.68e-03 463 4 2 0.500 0.004 MI:hsa-miR-194 mi 1 MI:hsa-miR-194 1 Q8N1G4,Q8NCM8 336 9.72e-03 464 4 2 0.500 0.004 MI:hsa-miR-875-3p mi 1 MI:hsa-miR-875-3p 1 Q8N1G4,Q8NCM8 336 9.72e-03 464 4 2 0.500 0.004 MI:hsa-miR-30a* mi 1 MI:hsa-miR-30a* 1 Q7L7X3,Q8NCM8 336 1.02e-02 475 4 2 0.500 0.004 MI:hsa-miR-425 mi 1 MI:hsa-miR-425 1 Q8N1G4,Q8NCM8 336 1.06e-02 34 4 1 0.250 0.029 TF:M06748_0 tf 1 Factor: ZN337; motif: KGKTAAGTCMGA; match class: 0 1 O60231 336 1.12e-02 4 4 1 0.250 0.250 HP:0005349 hp 1 Hypoplasia of the epiglottis 1 Q8NCM8 336 1.12e-02 4 4 1 0.250 0.250 HP:0011802 hp 1 Hamartoma of tongue 1 Q8NCM8 336 1.12e-02 4 4 1 0.250 0.250 HP:0100648 hp 1 Neoplasm of the tongue 1 Q8NCM8 336 1.35e-02 1991 4 3 0.750 0.002 TF:M04307_0 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 0 1 Q7L7X3,Q8NCM8,O60231 336 1.40e-02 5 4 1 0.250 0.200 HP:0010565 hp 1 Aplasia/Hypoplasia of the Epiglottis 1 Q8NCM8 336 1.40e-02 5 4 1 0.250 0.200 HP:0100629 hp 1 Midline facial cleft 1 Q8NCM8 336 1.40e-02 5 4 1 0.250 0.200 HP:0005483 hp 1 Abnormality of the epiglottis 1 Q8NCM8 336 1.43e-02 1722 4 3 0.750 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 Q8N1G4,Q7L7X3,Q8NCM8 336 1.47e-02 47 4 1 0.250 0.021 TF:M06924_0 tf 1 Factor: ZNF236; motif: NGGGGTAATTCT; match class: 0 1 O60231 336 1.47e-02 653 4 2 0.500 0.003 TF:M04332_1 tf 1 Factor: HMBOX1; motif: MYTAGTTAMN; match class: 1 1 Q8N1G4,Q7L7X3 336 1.53e-02 49 4 1 0.250 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 Q8NCM8 336 1.55e-02 4492 4 4 1.000 0.001 TF:M00339_0 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 1.60e-02 29 4 1 0.250 0.034 REAC:6811436 rea 1 COPI-independent Golgi-to-ER retrograde traffic 1 Q8NCM8 336 1.69e-02 596 4 2 0.500 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q8N1G4,O60231 336 1.70e-02 3899 4 4 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 1.72e-02 55 4 1 0.250 0.018 TF:M04111_1 tf 1 Factor: RUNX3; motif: WAACCRCAAA; match class: 1 1 Q8NCM8 336 1.84e-02 733 4 2 0.500 0.003 TF:M04471_0 tf 1 Factor: NR2E1; motif: AAGTCAANAAGTCA; match class: 0 1 Q8N1G4,Q8NCM8 336 1.84e-02 59 4 1 0.250 0.017 TF:M04291_1 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 1 1 Q8NCM8 336 1.86e-02 625 4 2 0.500 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q8N1G4,O60231 336 1.91e-02 634 4 2 0.500 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q8N1G4,O60231 336 1.92e-02 4019 4 4 1.000 0.001 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 2.00e-02 64 4 1 0.250 0.016 TF:M05826_0 tf 1 Factor: ZNF66; motif: GTSTTCAACTWA; match class: 0 1 Q8NCM8 336 2.09e-02 67 4 1 0.250 0.015 TF:M06624_0 tf 1 Factor: ZNF2; motif: NSATCGATCCGA; match class: 0 1 Q8NCM8 336 2.14e-02 1984 4 3 0.750 0.002 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 Q8N1G4,Q7L7X3,O60231 336 2.14e-02 1985 4 3 0.750 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,O60231 336 2.14e-02 39 4 1 0.250 0.026 REAC:5620924 rea 1 Intraflagellar transport 1 Q8NCM8 336 2.21e-02 2365 4 3 0.750 0.001 TF:M07424_0 tf 1 Factor: MEF-2; motif: NNYTATTTTTAGN; match class: 0 1 Q7L7X3,Q8NCM8,O60231 336 2.35e-02 2051 4 3 0.750 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,O60231 336 2.44e-02 2079 4 3 0.750 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q7L7X3,Q8NCM8,O60231 336 2.50e-02 730 4 2 0.500 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q8N1G4,O60231 336 2.51e-02 9 4 1 0.250 0.111 HP:0011315 hp 1 Unicoronal synostosis 1 Q8NCM8 336 2.51e-02 9 4 1 0.250 0.111 HP:0008797 hp 1 Early ossification of capital femoral epiphyses 1 Q8NCM8 336 2.54e-02 868 4 2 0.500 0.002 TF:M03838_0 tf 1 Factor: Otx1; motif: WASTAATCC; match class: 0 1 Q8NCM8,O60231 336 2.67e-02 755 4 2 0.500 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q8N1G4,O60231 336 2.67e-02 2146 4 3 0.750 0.001 HPA:021010_02 hpa 1 liver; bile duct cells[Uncertain,Medium] 1 Q7L7X3,Q8NCM8,O60231 336 2.71e-02 761 4 2 0.500 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 Q8N1G4,O60231 336 2.74e-02 88 4 1 0.250 0.011 TF:M05988_0 tf 1 Factor: ZNF860; motif: NTGGGAAAWGSM; match class: 0 1 Q8NCM8 336 2.79e-02 10 4 1 0.250 0.100 HP:0100866 hp 1 Short iliac bones 1 Q8NCM8 336 2.79e-02 10 4 1 0.250 0.100 HP:0004743 hp 1 Chronic tubulointerstitial nephritis 1 Q8NCM8 336 2.80e-02 775 4 2 0.500 0.003 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q8N1G4,O60231 336 2.84e-02 781 4 2 0.500 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q8N1G4,O60231 336 2.96e-02 5282 4 4 1.000 0.001 TF:M00913_0 tf 1 Factor: MYB; motif: NAACNGNCN; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 2.97e-02 38 4 1 0.250 0.026 KEGG:04962 keg 1 Vasopressin-regulated water reabsorption 1 Q8NCM8 336 2.98e-02 4485 4 4 1.000 0.001 HPA:011010_01 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Low] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 2.99e-02 802 4 2 0.500 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q7L7X3,O60231 336 2.99e-02 4491 4 4 1.000 0.001 HPA:048010_02 hpa 1 vagina; squamous epithelial cells[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 3.00e-02 3 4 1 0.250 0.333 GO:0009328 CC 1 phenylalanine-tRNA ligase complex 1 Q8N1G4 336 3.04e-02 98 4 1 0.250 0.010 TF:M03947_1 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 1 1 Q8N1G4 336 3.04e-02 98 4 1 0.250 0.010 TF:M07050_1 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 1 1 Q8NCM8 336 3.07e-02 11 4 1 0.250 0.091 HP:0006644 hp 1 Thoracic dysplasia 1 Q8NCM8 336 3.17e-02 102 4 1 0.250 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 O60231 336 3.17e-02 102 4 1 0.250 0.010 TF:M06385_0 tf 1 Factor: EZI; motif: NGGGCCTGGGGA; match class: 0 1 Q8NCM8 336 3.19e-02 2286 4 3 0.750 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q8N1G4,Q8NCM8,O60231 336 3.20e-02 103 4 1 0.250 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 Q8NCM8 336 3.25e-02 2712 4 3 0.750 0.001 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8 336 3.34e-02 12 4 1 0.250 0.083 HP:0009556 hp 1 Absent tibia 1 Q8NCM8 336 3.34e-02 12 4 1 0.250 0.083 HP:0005736 hp 1 Short tibia 1 Q8NCM8 336 3.34e-02 12 4 1 0.250 0.083 HP:0009817 hp 1 Aplasia involving bones of the lower limbs 1 Q8NCM8 336 3.34e-02 12 4 1 0.250 0.083 HP:0006557 hp 1 Polycystic liver disease 1 Q8NCM8 336 3.35e-02 108 4 1 0.250 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q8NCM8 336 3.43e-02 1016 4 2 0.500 0.002 TF:M06727_0 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 0 1 Q8N1G4,O60231 336 3.47e-02 867 4 2 0.500 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q8NCM8,O60231 336 3.47e-02 112 4 1 0.250 0.009 TF:M04363_1 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 1 1 Q8NCM8 336 3.47e-02 112 4 1 0.250 0.009 TF:M04357_1 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 1 1 Q8NCM8 336 3.54e-02 4682 4 4 1.000 0.001 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 3.54e-02 877 4 2 0.500 0.002 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q8N1G4,O60231 336 3.56e-02 879 4 2 0.500 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q7L7X3,O60231 336 3.57e-02 115 4 1 0.250 0.009 TF:M03947_0 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 0 1 Q8N1G4 336 3.61e-02 2816 4 3 0.750 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8 336 3.62e-02 13 4 1 0.250 0.077 HP:0000888 hp 1 Horizontal ribs 1 Q8NCM8 336 3.62e-02 13 4 1 0.250 0.077 HP:0000161 hp 1 Median cleft lip 1 Q8NCM8 336 3.62e-02 13 4 1 0.250 0.077 HP:0005054 hp 1 Metaphyseal spurs 1 Q8NCM8 336 3.62e-02 13 4 1 0.250 0.077 HP:0009107 hp 1 Abnormal ossification involving the femoral head and neck 1 Q8NCM8 336 3.62e-02 13 4 1 0.250 0.077 HP:0010454 hp 1 Acetabular spurs 1 Q8NCM8 336 3.72e-02 120 4 1 0.250 0.008 TF:M04108_1 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 1 1 Q8NCM8 336 3.73e-02 902 4 2 0.500 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q8N1G4,O60231 336 3.82e-02 4774 4 4 1.000 0.001 HPA:041020_01 hpa 1 spleen; cells in white pulp[Uncertain,Low] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 3.83e-02 1078 4 2 0.500 0.002 TF:M00414_1 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 1 1 Q8N1G4,O60231 336 3.86e-02 1082 4 2 0.500 0.002 TF:M07278_1 tf 1 Factor: Dlx3; motif: NTAATTNVN; match class: 1 1 Q8NCM8,O60231 336 3.87e-02 919 4 2 0.500 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q8N1G4,O60231 336 3.90e-02 126 4 1 0.250 0.008 TF:M00478_1 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 1 1 Q8NCM8 336 3.98e-02 73 4 1 0.250 0.014 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 Q8NCM8 336 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q8N1G4,O60231 336 4.15e-02 4872 4 4 1.000 0.001 HPA:025010_02 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 4.17e-02 15 4 1 0.250 0.067 HP:0002006 hp 1 Facial cleft 1 Q8NCM8 336 4.17e-02 15 4 1 0.250 0.067 HP:0000171 hp 1 Microglossia 1 Q8NCM8 336 4.17e-02 2966 4 3 0.750 0.001 TF:M01869_0 tf 1 Factor: C/EBPgamma; motif: NRTKRSRMAAKN; match class: 0 1 Q8N1G4,Q8NCM8,O60231 336 4.19e-02 1131 4 2 0.500 0.002 TF:M00183_1 tf 1 Factor: c-Myb; motif: NNNAACTGNC; match class: 1 1 Q8N1G4,Q7L7X3 336 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q8N1G4,O60231 336 4.27e-02 1142 4 2 0.500 0.002 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 Q8NCM8,O60231 336 4.39e-02 142 4 1 0.250 0.007 TF:M07115_0 tf 1 Factor: NF-YB; motif: NNNYNRRCCAATCAG; match class: 0 1 Q8N1G4 336 4.45e-02 16 4 1 0.250 0.062 HP:0002908 hp 1 Conjugated hyperbilirubinemia 1 Q8NCM8 336 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q8N1G4,O60231 336 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 Q8N1G4,O60231 336 4.55e-02 1182 4 2 0.500 0.002 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 Q7L7X3,O60231 336 4.63e-02 150 4 1 0.250 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 O60231 336 4.66e-02 151 4 1 0.250 0.007 TF:M04619_1 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 1 O60231 336 4.67e-02 5019 4 4 1.000 0.001 HPA:028010_02 hpa 1 parathyroid gland; glandular cells[Uncertain,Medium] 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 4.69e-02 152 4 1 0.250 0.007 TF:M05756_0 tf 1 Factor: ZNF470; motif: NTGTTTAWKAWA; match class: 0 1 Q8NCM8 336 4.72e-02 3100 4 3 0.750 0.001 TF:M00377_1 tf 1 Factor: Pax-4; motif: NAAWAATTANS; match class: 1 1 Q8N1G4,Q7L7X3,O60231 336 4.72e-02 17 4 1 0.250 0.059 HP:0010444 hp 1 Pulmonary insufficiency 1 Q8NCM8 336 4.72e-02 17 4 1 0.250 0.059 HP:0100649 hp 1 Neoplasm of the oral cavity 1 Q8NCM8 336 4.75e-02 1025 4 2 0.500 0.002 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q7L7X3,O60231 336 4.83e-02 5967 4 4 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 Q8N1G4,Q7L7X3,Q8NCM8,O60231 336 5.00e-02 5 4 1 0.250 0.200 GO:0006432 BP 1 phenylalanyl-tRNA aminoacylation 1 Q8N1G4 336 5.00e-02 16 4 1 0.250 0.062 CORUM:1141 cor 1 CF IIAm complex (Cleavage factor IIAm complex) 1 O60231 336 5.00e-02 18 4 1 0.250 0.056 HP:0003259 hp 1 Elevated serum creatinine 1 Q8NCM8 336 5.00e-02 12 4 1 0.250 0.083 OMIM:208500 omi 1 Asphyxiating Thoracic Dysplasia 1 Q8NCM8 336 5.00e-02 5 4 1 0.250 0.200 GO:0004826 MF 1 phenylalanine-tRNA ligase activity 1 Q8N1G4 336 5.00e-02 18 4 1 0.250 0.056 HP:0012100 hp 1 Abnormal circulating creatinine level 1 Q8NCM8 336 5.00e-02 18 4 1 0.250 0.056 HP:0006956 hp 1 Dilation of lateral ventricles 1 Q8NCM8 336 5.00e-02 18 4 1 0.250 0.056 HP:0003027 hp 1 Mesomelia 1 Q8NCM8 337 3.40e-03 7 1 1 1.000 0.143 CORUM:924 cor 1 Toposome 1 Q96SB4 337 9.71e-03 20 1 1 1.000 0.050 CORUM:1332 cor 1 Large Drosha complex 1 Q96SB4 337 3.23e-02 328 1 1 1.000 0.003 MI:hsa-miR-146a* mi 1 MI:hsa-miR-146a* 1 Q96SB4 337 3.97e-02 403 1 1 1.000 0.002 MI:hsa-miR-526b mi 1 MI:hsa-miR-526b 1 Q96SB4 337 4.63e-02 469 1 1 1.000 0.002 MI:mmu-miR-685 mi 1 MI:mmu-miR-685 1 Q96SB4 337 4.87e-02 494 1 1 1.000 0.002 MI:hsa-miR-452 mi 1 MI:hsa-miR-452 1 Q96SB4 337 5.00e-02 5 1 1 1.000 0.200 GO:0035092 BP 1 sperm chromatin condensation 1 Q96SB4 337 5.00e-02 103 1 1 1.000 0.010 CORUM:3055 cor 1 Nop56p-associated pre-rRNA complex 1 Q96SB4 337 5.00e-02 145 1 1 1.000 0.007 KEGG:05168 keg 1 Herpes simplex infection 1 Q96SB4 337 5.00e-02 8 1 1 1.000 0.125 TF:M04045_1 tf 1 Factor: MYBL1; motif: GNCNGTTANWACSGTTR; match class: 1 1 Q96SB4 337 5.00e-02 507 1 1 1.000 0.002 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 Q96SB4 338 1.00e-02 1 5 1 0.200 1.000 GO:1990032 CC 1 parallel fiber 1 Q5VWQ8 338 1.00e-02 1 5 1 0.200 1.000 GO:0021814 BP 1 cell motility involved in cerebral cortex radial glia guided migration 1 Q5VWQ8 338 1.00e-02 1 5 1 0.200 1.000 GO:0044301 CC 1 climbing fiber 1 Q5VWQ8 338 1.00e-02 1 5 1 0.200 1.000 GO:1990597 CC 1 AIP1-IRE1 complex 1 Q5VWQ8 338 1.65e-02 24 5 1 0.200 0.042 REAC:8849471 rea 1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 Q5VWQ8 338 2.00e-02 2 5 1 0.200 0.500 GO:0004066 MF 1 asparagine synthase (glutamine-hydrolyzing) activity 1 Q9NWL6 338 2.00e-02 2 5 1 0.200 0.500 GO:0044300 CC 1 cerebellar mossy fiber 1 Q5VWQ8 338 2.00e-02 2 5 1 0.200 0.500 GO:0043553 BP 1 negative regulation of phosphatidylinositol 3-kinase activity 1 Q5VWQ8 338 2.00e-02 2 5 1 0.200 0.500 GO:0006529 BP 1 asparagine biosynthetic process 1 Q9NWL6 338 2.00e-02 2 5 1 0.200 0.500 GO:0036324 BP 1 vascular endothelial growth factor receptor-2 signaling pathway 1 Q5VWQ8 338 2.00e-02 2 5 1 0.200 0.500 GO:0070317 BP 1 negative regulation of G0 to G1 transition 1 Q5VWQ8 338 2.00e-02 2 5 1 0.200 0.500 GO:0021819 BP 1 layer formation in cerebral cortex 1 Q5VWQ8 338 3.00e-02 3 5 1 0.200 0.333 GO:1900747 BP 1 negative regulation of vascular endothelial growth factor signaling pathway 1 Q5VWQ8 338 3.00e-02 3 5 1 0.200 0.333 GO:0090219 BP 1 negative regulation of lipid kinase activity 1 Q5VWQ8 338 3.00e-02 3 5 1 0.200 0.333 GO:0070316 BP 1 regulation of G0 to G1 transition 1 Q5VWQ8 338 3.82e-02 56 5 1 0.200 0.018 REAC:8848021 rea 1 Signaling by PTK6 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0035662 MF 1 Toll-like receptor 4 binding 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:1902548 BP 1 negative regulation of cellular response to vascular endothelial growth factor stimulus 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0043184 MF 1 vascular endothelial growth factor receptor 2 binding 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0021801 BP 1 cerebral cortex radial glia guided migration 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0034144 BP 1 negative regulation of toll-like receptor 4 signaling pathway 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0030948 BP 1 negative regulation of vascular endothelial growth factor receptor signaling pathway 1 Q5VWQ8 338 4.00e-02 4 5 1 0.200 0.250 GO:0022030 BP 1 telencephalon glial cell migration 1 Q5VWQ8 338 4.49e-02 66 5 1 0.200 0.015 REAC:5658442 rea 1 Regulation of RAS by GAPs 1 Q5VWQ8 338 5.00e-02 63 5 2 0.400 0.032 TF:M06189_0 tf 1 Factor: ZNF91; motif: KGKTAGGRCAKA; match class: 0 1 Q5VWQ8,Q9NWL6 338 5.00e-02 5 5 1 0.200 0.200 GO:0032809 CC 1 neuronal cell body membrane 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0006528 BP 1 asparagine metabolic process 1 Q9NWL6 338 5.00e-02 5 5 1 0.200 0.200 GO:0005172 MF 1 vascular endothelial growth factor receptor binding 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0021799 BP 1 cerebral cortex radially oriented cell migration 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0036312 MF 1 phosphatidylinositol 3-kinase regulatory subunit binding 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0043497 BP 1 regulation of protein heterodimerization activity 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:1903726 BP 1 negative regulation of phospholipid metabolic process 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0014067 BP 1 negative regulation of phosphatidylinositol 3-kinase signaling 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0045023 BP 1 G0 to G1 transition 1 Q5VWQ8 338 5.00e-02 5 5 1 0.200 0.200 GO:0044298 CC 1 cell body membrane 1 Q5VWQ8 338 5.00e-02 380 5 3 0.600 0.008 MI:hsa-miR-374b mi 1 MI:hsa-miR-374b 1 O75677,O75678,Q9NWL6 339 3.79e-03 4 2 1 0.500 0.250 REAC:211163 rea 1 AKT-mediated inactivation of FOXO1A 1 Q9Y243 339 5.68e-03 6 2 1 0.500 0.167 REAC:196791 rea 1 Vitamin D (calciferol) metabolism 1 Q99538 339 7.57e-03 8 2 1 0.500 0.125 REAC:1679131 rea 1 Trafficking and processing of endosomal TLR 1 Q99538 339 7.57e-03 8 2 1 0.500 0.125 REAC:198693 rea 1 AKT phosphorylates targets in the nucleus 1 Q9Y243 339 1.04e-02 11 2 1 0.500 0.091 REAC:210745 rea 1 Regulation of gene expression in beta cells 1 Q9Y243 339 1.14e-02 12 2 1 0.500 0.083 REAC:6804759 rea 1 Regulation of TP53 Activity through Association with Co-factors 1 Q9Y243 339 1.14e-02 12 2 1 0.500 0.083 REAC:1358803 rea 1 Downregulation of ERBB2:ERBB3 signaling 1 Q9Y243 339 1.23e-02 13 2 1 0.500 0.077 REAC:198323 rea 1 AKT phosphorylates targets in the cytosol 1 Q9Y243 339 1.42e-02 15 2 1 0.500 0.067 REAC:111447 rea 1 Activation of BAD and translocation to mitochondria 1 Q9Y243 339 1.61e-02 17 2 1 0.500 0.059 REAC:186712 rea 1 Regulation of beta-cell development 1 Q9Y243 339 1.61e-02 17 2 1 0.500 0.059 REAC:389357 rea 1 CD28 dependent PI3K/Akt signaling 1 Q9Y243 339 1.80e-02 19 2 1 0.500 0.053 REAC:389513 rea 1 CTLA4 inhibitory signaling 1 Q9Y243 339 2.17e-02 23 2 1 0.500 0.043 REAC:5674400 rea 1 Constitutive Signaling by AKT1 E17K in Cancer 1 Q9Y243 339 2.27e-02 24 2 1 0.500 0.042 REAC:5218920 rea 1 VEGFR2 mediated vascular permeability 1 Q9Y243 339 2.27e-02 33 2 1 0.500 0.030 KEGG:04973 keg 1 Carbohydrate digestion and absorption 1 Q9Y243 339 2.47e-02 614 2 2 1.000 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 Q99538,Q9Y243 339 2.55e-02 27 2 1 0.500 0.037 REAC:114452 rea 1 Activation of BH3-only proteins 1 Q9Y243 339 2.61e-02 38 2 1 0.500 0.026 KEGG:04923 keg 1 Regulation of lipolysis in adipocytes 1 Q9Y243 339 2.65e-02 28 2 1 0.500 0.036 REAC:389356 rea 1 CD28 co-stimulation 1 Q9Y243 339 2.83e-02 30 2 1 0.500 0.033 REAC:6804758 rea 1 Regulation of TP53 Activity through Acetylation 1 Q9Y243 339 3.02e-02 32 2 1 0.500 0.031 REAC:6804757 rea 1 Regulation of TP53 Degradation 1 Q9Y243 339 3.09e-02 45 2 1 0.500 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 Q99538 339 3.12e-02 33 2 1 0.500 0.030 REAC:6806003 rea 1 Regulation of TP53 Expression and Degradation 1 Q9Y243 339 3.31e-02 35 2 1 0.500 0.029 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 Q9Y243 339 3.36e-02 49 2 1 0.500 0.020 KEGG:05213 keg 1 Endometrial cancer 1 Q9Y243 339 3.49e-02 37 2 1 0.500 0.027 REAC:114604 rea 1 GPVI-mediated activation cascade 1 Q9Y243 339 3.57e-02 52 2 1 0.500 0.019 KEGG:05223 keg 1 Non-small cell lung cancer 1 Q9Y243 339 3.57e-02 52 2 1 0.500 0.019 KEGG:05221 keg 1 Acute myeloid leukemia 1 Q9Y243 339 3.59e-02 38 2 1 0.500 0.026 REAC:397795 rea 1 G-protein beta:gamma signalling 1 Q9Y243 339 3.68e-02 39 2 1 0.500 0.026 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 Q9Y243 339 3.71e-02 54 2 1 0.500 0.019 KEGG:04370 keg 1 VEGF signaling pathway 1 Q9Y243 339 3.71e-02 54 2 1 0.500 0.019 KEGG:04664 keg 1 Fc epsilon RI signaling pathway 1 Q9Y243 339 3.71e-02 54 2 1 0.500 0.019 KEGG:05218 keg 1 Melanoma 1 Q9Y243 339 3.84e-02 56 2 1 0.500 0.018 KEGG:04917 keg 1 Prolactin signaling pathway 1 Q9Y243 339 3.87e-02 41 2 1 0.500 0.024 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 Q99538 339 3.91e-02 57 2 1 0.500 0.018 KEGG:04213 keg 1 Longevity regulating pathway - multiple species 1 Q9Y243 339 3.91e-02 57 2 1 0.500 0.018 KEGG:05214 keg 1 Glioma 1 Q9Y243 339 3.98e-02 58 2 1 0.500 0.017 KEGG:04920 keg 1 Adipocytokine signaling pathway 1 Q9Y243 339 3.98e-02 58 2 1 0.500 0.017 KEGG:05210 keg 1 Colorectal cancer 1 Q9Y243 339 4.05e-02 59 2 1 0.500 0.017 KEGG:04662 keg 1 B cell receptor signaling pathway 1 Q9Y243 339 4.05e-02 59 2 1 0.500 0.017 KEGG:05211 keg 1 Renal cell carcinoma 1 Q9Y243 339 4.06e-02 43 2 1 0.500 0.023 REAC:1227986 rea 1 Signaling by ERBB2 1 Q9Y243 339 4.18e-02 61 2 1 0.500 0.016 KEGG:05212 keg 1 Pancreatic cancer 1 Q9Y243 339 4.39e-02 64 2 1 0.500 0.016 KEGG:05230 keg 1 Central carbon metabolism in cancer 1 Q9Y243 339 4.73e-02 69 2 1 0.500 0.014 KEGG:05220 keg 1 Chronic myeloid leukemia 1 Q9Y243 339 4.80e-02 70 2 1 0.500 0.014 KEGG:04620 keg 1 Toll-like receptor signaling pathway 1 Q9Y243 339 4.86e-02 71 2 1 0.500 0.014 KEGG:01524 keg 1 Platinum drug resistance 1 Q9Y243 339 5.00e-02 4 2 1 0.500 0.250 HP:0010775 hp 1 Vascular ring 1 Q9Y243 339 5.00e-02 445 2 2 1.000 0.004 MI:hsa-miR-556-5p mi 1 MI:hsa-miR-556-5p 1 Q99538,Q9Y243 339 5.00e-02 2 2 1 0.500 0.500 GO:0006624 BP 1 vacuolar protein processing 1 Q99538 339 5.00e-02 53 2 1 0.500 0.019 REAC:388841 rea 1 Costimulation by the CD28 family 1 Q9Y243 339 5.00e-02 73 2 1 0.500 0.014 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 Q9Y243 340 1.31e-05 21 2 2 1.000 0.095 GO:0016538 MF 1 cyclin-dependent protein serine/threonine kinase regulator activity 1 P42773,P11802 340 2.41e-05 30 2 2 1.000 0.067 REAC:2559585 rea 1 Oncogene Induced Senescence 1 P42773,P11802 340 3.69e-05 37 2 2 1.000 0.054 REAC:69231 rea 1 Cyclin D associated events in G1 1 P42773,P11802 340 3.69e-05 37 2 2 1.000 0.054 REAC:69236 rea 1 G1 Phase 1 P42773,P11802 340 9.16e-05 58 2 2 1.000 0.034 REAC:2559582 rea 1 Senescence-Associated Secretory Phenotype (SASP) 1 P42773,P11802 340 1.54e-04 75 2 2 1.000 0.027 REAC:2559580 rea 1 Oxidative Stress Induced Senescence 1 P42773,P11802 340 3.88e-04 112 2 2 1.000 0.018 GO:0019887 MF 1 protein kinase regulator activity 1 P42773,P11802 340 4.76e-04 124 2 2 1.000 0.016 GO:0019207 MF 1 kinase regulator activity 1 P42773,P11802 340 5.24e-04 138 2 2 1.000 0.014 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P42773,P11802 340 5.24e-04 138 2 2 1.000 0.014 REAC:2559583 rea 1 Cellular Senescence 1 P42773,P11802 340 6.64e-04 87 2 2 1.000 0.023 KEGG:01522 keg 1 Endocrine resistance 1 P42773,P11802 340 9.84e-04 178 2 2 1.000 0.011 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P42773,P11802 340 1.01e-03 180 2 2 1.000 0.011 GO:0007050 BP 1 cell cycle arrest 1 P42773,P11802 340 1.06e-03 185 2 2 1.000 0.011 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P42773,P11802 340 1.11e-03 48 2 2 1.000 0.042 HP:0002894 hp 1 Neoplasm of the pancreas 1 P42773,P11802 340 1.20e-03 117 2 2 1.000 0.017 KEGG:04110 keg 1 Cell cycle 1 P42773,P11802 340 2.00e-03 5 2 1 0.500 0.200 REAC:8849470 rea 1 PTK6 Regulates Cell Cycle 1 P11802 340 3.95e-03 378 2 2 1.000 0.005 REAC:2262752 rea 1 Cellular responses to stress 1 P42773,P11802 340 4.20e-03 218 2 2 1.000 0.009 KEGG:05166 keg 1 HTLV-I infection 1 P42773,P11802 340 4.40e-03 376 2 2 1.000 0.005 GO:0045786 BP 1 negative regulation of cell cycle 1 P42773,P11802 340 5.26e-03 411 2 2 1.000 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P42773,P11802 340 5.55e-03 448 2 2 1.000 0.004 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P42773,P11802 340 5.63e-03 425 2 2 1.000 0.005 GO:0044770 BP 1 cell cycle phase transition 1 P42773,P11802 340 6.48e-03 9 2 1 0.500 0.111 GO:0004861 MF 1 cyclin-dependent protein serine/threonine kinase inhibitor activity 1 P42773 340 7.15e-03 1 2 1 0.500 1.000 OMIM:609048 omi 1 MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 3; CMM3 1 P11802 340 7.20e-03 10 2 1 0.500 0.100 GO:0010971 BP 1 positive regulation of G2/M transition of mitotic cell cycle 1 P11802 340 7.50e-03 124 2 2 1.000 0.016 HP:0100242 hp 1 Sarcoma 1 P42773,P11802 340 7.62e-03 125 2 2 1.000 0.016 HP:0008069 hp 1 Neoplasm of the skin 1 P42773,P11802 340 7.92e-03 11 2 1 0.500 0.091 GO:1902751 BP 1 positive regulation of cell cycle G2/M phase transition 1 P11802 340 8.27e-03 547 2 2 1.000 0.004 REAC:1640170 rea 1 Cell Cycle 1 P42773,P11802 340 9.36e-03 13 2 1 0.500 0.077 GO:0071157 BP 1 negative regulation of cell cycle arrest 1 P11802 340 9.43e-03 139 2 2 1.000 0.014 HP:0007378 hp 1 Neoplasm of the gastrointestinal tract 1 P42773,P11802 340 1.01e-02 14 2 1 0.500 0.071 GO:0030332 MF 1 cyclin binding 1 P11802 340 1.01e-02 14 2 1 0.500 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 P11802 340 1.01e-02 14 2 1 0.500 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 P11802 340 1.06e-02 582 2 2 1.000 0.003 GO:0030234 MF 1 enzyme regulator activity 1 P42773,P11802 340 1.32e-02 5 2 1 0.500 0.200 HP:0012197 hp 1 Insulinoma 1 P42773 340 1.32e-02 5 2 1 0.500 0.200 HP:0100633 hp 1 Esophagitis 1 P42773 340 1.32e-02 5 2 1 0.500 0.200 HP:0008261 hp 1 Pancreatic islet cell adenoma 1 P42773 340 1.32e-02 5 2 1 0.500 0.200 HP:0030404 hp 1 Glucagonoma 1 P42773 340 1.32e-02 5 2 1 0.500 0.200 HP:0030405 hp 1 Pancreatic endocrine tumor 1 P42773 340 1.32e-02 5 2 1 0.500 0.200 HP:0007449 hp 1 Confetti-like hypopigmented macules 1 P42773 340 1.35e-02 657 2 2 1.000 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 P42773,P11802 340 1.36e-02 34 2 1 0.500 0.029 REAC:3214858 rea 1 RMTs methylate histone arginines 1 P11802 340 1.38e-02 168 2 2 1.000 0.012 HP:0001732 hp 1 Abnormality of the pancreas 1 P42773,P11802 340 1.41e-02 672 2 2 1.000 0.003 GO:0042127 BP 1 regulation of cell proliferation 1 P42773,P11802 340 1.44e-02 679 2 2 1.000 0.003 GO:0051726 BP 1 regulation of cell cycle 1 P42773,P11802 340 1.58e-02 6 2 1 0.500 0.167 HP:0008256 hp 1 Adrenocortical adenoma 1 P42773 340 1.58e-02 6 2 1 0.500 0.167 HP:0002044 hp 1 Zollinger-Ellison syndrome 1 P42773 340 1.58e-02 6 2 1 0.500 0.167 HP:0100570 hp 1 Carcinoid tumor 1 P42773 340 1.58e-02 22 2 1 0.500 0.045 GO:0030291 MF 1 protein serine/threonine kinase inhibitor activity 1 P42773 340 1.58e-02 22 2 1 0.500 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 P11802 340 1.62e-02 721 2 2 1.000 0.003 GO:0000278 BP 1 mitotic cell cycle 1 P42773,P11802 340 1.64e-02 41 2 1 0.500 0.024 REAC:912446 rea 1 Meiotic recombination 1 P11802 340 1.85e-02 7 2 1 0.500 0.143 HP:0001074 hp 1 Atypical nevi in non-sun exposed areas 1 P11802 340 1.85e-02 7 2 1 0.500 0.143 HP:0006767 hp 1 Pituitary prolactin cell adenoma 1 P42773 340 1.85e-02 7 2 1 0.500 0.143 HP:0001062 hp 1 Atypical nevus 1 P11802 340 1.90e-02 197 2 2 1.000 0.010 HP:0011792 hp 1 Neoplasm by histology 1 P42773,P11802 340 1.99e-02 50 2 1 0.500 0.020 REAC:75815 rea 1 Ubiquitin-dependent degradation of Cyclin D 1 P11802 340 1.99e-02 50 2 1 0.500 0.020 REAC:69229 rea 1 Ubiquitin-dependent degradation of Cyclin D1 1 P11802 340 2.11e-02 8 2 1 0.500 0.125 HP:0007716 hp 1 Intraocular melanoma 1 P11802 340 2.11e-02 8 2 1 0.500 0.125 HP:0002897 hp 1 Parathyroid adenoma 1 P42773 340 2.14e-02 828 2 2 1.000 0.002 GO:0098772 MF 1 molecular function regulator 1 P42773,P11802 340 2.16e-02 30 2 1 0.500 0.033 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 P11802 340 2.23e-02 31 2 1 0.500 0.032 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 P11802 340 2.23e-02 56 2 1 0.500 0.018 REAC:8848021 rea 1 Signaling by PTK6 1 P11802 340 2.31e-02 58 2 1 0.500 0.017 REAC:187577 rea 1 SCF(Skp2)-mediated degradation of p27/p21 1 P11802 340 2.37e-02 9 2 1 0.500 0.111 HP:0002893 hp 1 Pituitary adenoma 1 P42773 340 2.37e-02 33 2 1 0.500 0.030 GO:0010389 BP 1 regulation of G2/M transition of mitotic cell cycle 1 P11802 340 2.45e-02 34 2 1 0.500 0.029 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 P11802 340 2.50e-02 2 2 1 0.500 0.500 CORUM:5287 cor 1 CDK4-CCND1 complex 1 P11802 340 2.50e-02 2 2 1 0.500 0.500 CORUM:3084 cor 1 CCND1-CDK4 complex 1 P11802 340 2.50e-02 2 2 1 0.500 0.500 CORUM:3086 cor 1 CCND3-CDK4 complex 1 P11802 340 2.50e-02 2 2 1 0.500 0.500 CORUM:5107 cor 1 p34(SEI-1)-CDK4-CyclinD2 complex 1 P11802 340 2.50e-02 2 2 1 0.500 0.500 CORUM:3085 cor 1 CCND2-CDK4 complex 1 P11802 340 2.54e-02 363 2 2 1.000 0.006 MI:mmu-miR-701 mi 1 MI:mmu-miR-701 1 P42773,P11802 340 2.56e-02 906 2 2 1.000 0.002 GO:0008283 BP 1 cell proliferation 1 P42773,P11802 340 2.64e-02 10 2 1 0.500 0.100 HP:0009719 hp 1 Hypomelanotic macule 1 P42773 340 2.64e-02 10 2 1 0.500 0.100 HP:0011750 hp 1 Neoplasm of the anterior pituitary 1 P42773 340 2.64e-02 10 2 1 0.500 0.100 HP:0001031 hp 1 Subcutaneous lipoma 1 P42773 340 2.66e-02 37 2 1 0.500 0.027 GO:0048145 BP 1 regulation of fibroblast proliferation 1 P11802 340 2.71e-02 68 2 1 0.500 0.015 REAC:1500620 rea 1 Meiosis 1 P11802 340 2.71e-02 68 2 1 0.500 0.015 REAC:69656 rea 1 Cyclin A:Cdk2-associated events at S phase entry 1 P11802 340 2.71e-02 68 2 1 0.500 0.015 REAC:381340 rea 1 Transcriptional regulation of white adipocyte differentiation 1 P11802 340 2.73e-02 38 2 1 0.500 0.026 GO:0048144 BP 1 fibroblast proliferation 1 P11802 340 2.75e-02 69 2 1 0.500 0.014 REAC:69202 rea 1 Cyclin E associated events during G1/S transition 1 P11802 340 2.80e-02 39 2 1 0.500 0.026 GO:1902749 BP 1 regulation of cell cycle G2/M phase transition 1 P11802 340 2.83e-02 952 2 2 1.000 0.002 GO:0022402 BP 1 cell cycle process 1 P42773,P11802 340 2.90e-02 11 2 1 0.500 0.091 HP:0100733 hp 1 Neoplasm of the parathyroid gland 1 P42773 340 2.90e-02 11 2 1 0.500 0.091 HP:0100012 hp 1 Neoplasm of the eye 1 P11802 340 2.94e-02 245 2 2 1.000 0.008 HP:0002577 hp 1 Abnormality of the stomach 1 P42773,P11802 340 3.16e-02 12 2 1 0.500 0.083 HP:0100641 hp 1 Neoplasm of the adrenal cortex 1 P42773 340 3.22e-02 36 2 1 0.500 0.028 KEGG:05219 keg 1 Bladder cancer 1 P11802 340 3.42e-02 13 2 1 0.500 0.077 HP:0000845 hp 1 Growth hormone excess 1 P42773 340 3.42e-02 13 2 1 0.500 0.077 HP:0001054 hp 1 Numerous nevi 1 P11802 340 3.42e-02 13 2 1 0.500 0.077 HP:0012056 hp 1 Cutaneous melanoma 1 P11802 340 3.56e-02 1068 2 2 1.000 0.002 GO:0006468 BP 1 protein phosphorylation 1 P42773,P11802 340 3.75e-02 3 2 1 0.500 0.333 CORUM:1642 cor 1 p16-cyclin D2-CDK4 complex 1 P11802 340 3.75e-02 3 2 1 0.500 0.333 CORUM:1633 cor 1 CyclinD1-CDK4-CDK6 complex 1 P11802 340 3.75e-02 3 2 1 0.500 0.333 CORUM:5100 cor 1 CyclinD3-CDK4-CDK6 complex 1 P11802 340 3.95e-02 15 2 1 0.500 0.067 HP:0004398 hp 1 Peptic ulcer 1 P42773 340 3.95e-02 15 2 1 0.500 0.067 HP:0001578 hp 1 Hypercortisolism 1 P42773 340 3.95e-02 15 2 1 0.500 0.067 HP:0000843 hp 1 Hyperparathyroidism 1 P42773 340 3.97e-02 1128 2 2 1.000 0.002 GO:0007049 BP 1 cell cycle 1 P42773,P11802 340 4.38e-02 61 2 1 0.500 0.016 GO:0004860 MF 1 protein kinase inhibitor activity 1 P42773 340 4.45e-02 62 2 1 0.500 0.016 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 P42773 340 4.45e-02 62 2 1 0.500 0.016 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 P42773 340 4.48e-02 17 2 1 0.500 0.059 HP:0012093 hp 1 Abnormality of endocrine pancreas physiology 1 P42773 340 4.48e-02 17 2 1 0.500 0.059 HP:0006476 hp 1 Abnormality of the pancreatic islet cells 1 P42773 340 4.48e-02 17 2 1 0.500 0.059 HP:0100634 hp 1 Neuroendocrine neoplasm 1 P42773 340 4.53e-02 63 2 1 0.500 0.016 GO:0019210 MF 1 kinase inhibitor activity 1 P42773 340 4.57e-02 115 2 1 0.500 0.009 REAC:69206 rea 1 G1/S Transition 1 P11802 340 4.62e-02 307 2 2 1.000 0.007 HP:0001000 hp 1 Abnormality of skin pigmentation 1 P42773,P11802 340 4.64e-02 52 2 1 0.500 0.019 KEGG:05223 keg 1 Non-small cell lung cancer 1 P11802 340 4.65e-02 491 2 2 1.000 0.004 MI:mmu-miR-743b-5p mi 1 MI:mmu-miR-743b-5p 1 P42773,P11802 340 4.82e-02 54 2 1 0.500 0.019 KEGG:05218 keg 1 Melanoma 1 P11802 340 4.95e-02 69 2 1 0.500 0.014 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 P11802 340 5.00e-02 126 2 1 0.500 0.008 REAC:69242 rea 1 S Phase 1 P11802 340 5.00e-02 4 2 1 0.500 0.250 CORUM:5101 cor 1 CyclinD3-CDK4-CDK6-p21 complex 1 P11802 340 5.00e-02 7 2 1 0.500 0.143 OMIM:155600 omi 1 Susceptibility to Cutaneous Malignant Melanoma 1 P11802 340 5.00e-02 56 2 1 0.500 0.018 KEGG:04115 keg 1 p53 signaling pathway 1 P11802 340 5.00e-02 19 2 1 0.500 0.053 HP:0011766 hp 1 Abnormality of the parathyroid morphology 1 P42773 340 5.00e-02 4 2 1 0.500 0.250 CORUM:312 cor 1 Cell cycle kinase complex CDK4 1 P11802 340 5.00e-02 1266 2 2 1.000 0.002 GO:0016310 BP 1 phosphorylation 1 P42773,P11802 340 5.00e-02 509 2 2 1.000 0.004 MI:hsa-miR-885-3p mi 1 MI:hsa-miR-885-3p 1 P42773,P11802 341 4.83e-04 35 4 2 0.500 0.057 GO:0032414 BP 1 positive regulation of ion transmembrane transporter activity 1 Q9H4A3,Q13586 341 6.65e-04 41 4 2 0.500 0.049 GO:0032411 BP 1 positive regulation of transporter activity 1 Q9H4A3,Q13586 341 8.76e-04 47 4 2 0.500 0.043 GO:0034767 BP 1 positive regulation of ion transmembrane transport 1 Q9H4A3,Q13586 341 1.07e-03 52 4 2 0.500 0.038 GO:0034764 BP 1 positive regulation of transmembrane transport 1 Q9H4A3,Q13586 341 1.29e-03 57 4 2 0.500 0.035 GO:0099106 MF 1 ion channel regulator activity 1 Q9H4A3,Q13586 341 2.30e-03 76 4 2 0.500 0.026 GO:0016247 MF 1 channel regulator activity 1 Q9H4A3,Q13586 341 3.14e-03 1 4 1 0.250 1.000 HP:0010522 hp 1 Dyslexia 1 Q13586 341 3.16e-03 89 4 2 0.500 0.022 GO:0043270 BP 1 positive regulation of ion transport 1 Q9H4A3,Q13586 341 3.87e-03 1 4 1 0.250 1.000 OMIM:185070 omi 1 STORMORKEN SYNDROME; STRMK;;THROMBOCYTOPATHY, ASPLENIA, AND MIOSIS;;YORK PLATELET SYNDROME; YPS 1 Q13586 341 3.87e-03 1 4 1 0.250 1.000 OMIM:201300 omi 1 NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IIA; HSAN2A;;HSAN IIA;;NEUROPATHY, HEREDITARY SENSORY, TYPE IIA; HSN2A;;HSN IIA;;ACROOSTEOLYSIS, NEUROGENIC;;ACROOSTEOLYSIS, GIACCAI TYPE;;NEUROPATHY, HEREDITARY SENSORY RADICULAR, AUTOSOMAL RECESSIVE;;MORVAN DISEASE;;NEUROPATHY, PROGRESSIVE SENSORY, OF CHILDREN;;NEUROPATHY, CONGENITAL SENSORY 1 Q9H4A3 341 3.87e-03 1 4 1 0.250 1.000 OMIM:612783 omi 1 IMMUNODEFICIENCY 10; IMD10;;IMMUNE DYSFUNCTION WITH T-CELL INACTIVATION DUE TO CALCIUM ENTRY DEFECT2;;STIM1 DEFICIENCY 1 Q13586 341 3.87e-03 1 4 1 0.250 1.000 OMIM:614492 omi 1 PSEUDOHYPOALDOSTERONISM, TYPE IIC; PHA2C 1 Q9H4A3 341 4.31e-03 104 4 2 0.500 0.019 GO:0032412 BP 1 regulation of ion transmembrane transporter activity 1 Q9H4A3,Q13586 341 4.39e-03 105 4 2 0.500 0.019 GO:0022898 BP 1 regulation of transmembrane transporter activity 1 Q9H4A3,Q13586 341 5.36e-03 116 4 2 0.500 0.017 GO:0032409 BP 1 regulation of transporter activity 1 Q9H4A3,Q13586 341 5.64e-03 351 4 2 0.500 0.006 MI:hsa-miR-17* mi 1 MI:hsa-miR-17* 1 Q9H4A3,Q8TCB7 341 6.26e-03 2 4 1 0.250 0.500 GO:0023016 BP 1 signal transduction by trans-phosphorylation 1 Q9H4A3 341 7.36e-03 136 4 2 0.500 0.015 GO:0034765 BP 1 regulation of ion transmembrane transport 1 Q9H4A3,Q13586 341 8.08e-03 422 4 2 0.500 0.005 MI:hsa-miR-490-5p mi 1 MI:hsa-miR-490-5p 1 Q13586,Q8TCB7 341 8.13e-03 143 4 2 0.500 0.014 GO:0034762 BP 1 regulation of transmembrane transport 1 Q9H4A3,Q13586 341 8.36e-03 145 4 2 0.500 0.014 GO:0010959 BP 1 regulation of metal ion transport 1 Q9H4A3,Q13586 341 9.39e-03 3 4 1 0.250 0.333 GO:1901341 BP 1 positive regulation of store-operated calcium channel activity 1 Q13586 341 9.39e-03 3 4 1 0.250 0.333 GO:0032237 BP 1 activation of store-operated calcium channel activity 1 Q13586 341 9.39e-03 3 4 1 0.250 0.333 GO:0070166 BP 1 enamel mineralization 1 Q13586 341 9.39e-03 3 4 1 0.250 0.333 GO:0032541 CC 1 cortical endoplasmic reticulum 1 Q13586 341 1.15e-02 1864 4 4 1.000 0.002 TF:M03899_0 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 0 1 Q9H4A3,Q13586,Q7Z401,Q8TCB7 341 1.25e-02 4 4 1 0.250 0.250 GO:1901339 BP 1 regulation of store-operated calcium channel activity 1 Q13586 341 1.25e-02 4 4 1 0.250 0.250 HP:0011423 hp 1 Hyperchloremia 1 Q9H4A3 341 1.25e-02 4 4 1 0.250 0.250 HP:0006121 hp 1 Acral ulceration leading to autoamputation of digits 1 Q9H4A3 341 1.25e-02 4 4 1 0.250 0.250 HP:0009005 hp 1 Weakness of the intrinsic hand muscles 1 Q13586 341 1.26e-02 828 4 3 0.750 0.004 GO:0098772 MF 1 molecular function regulator 1 Q9H4A3,Q13586,Q7Z401 341 1.43e-02 1722 4 3 0.750 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 Q9H4A3,Q13586,Q8TCB7 341 1.55e-02 4 4 1 0.250 0.250 OMIM:145260 omi 1 Pseudohypoaldosteronism Type II 1 Q9H4A3 341 1.57e-02 5 4 1 0.250 0.200 HP:0001069 hp 1 Episodic hyperhidrosis 1 Q9H4A3 341 1.74e-02 210 4 2 0.500 0.010 GO:0043269 BP 1 regulation of ion transport 1 Q9H4A3,Q13586 341 1.88e-02 6 4 1 0.250 0.167 GO:0005513 BP 1 detection of calcium ion 1 Q13586 341 1.88e-02 6 4 1 0.250 0.167 HP:0000224 hp 1 Decreased taste sensation 1 Q9H4A3 341 1.88e-02 6 4 1 0.250 0.167 HP:0000223 hp 1 Abnormality of taste sensation 1 Q9H4A3 341 1.93e-02 10 4 1 0.250 0.100 REAC:139853 rea 1 Elevation of cytosolic Ca2+ levels 1 Q13586 341 2.01e-02 756 4 3 0.750 0.004 TF:M00425_1 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 1 1 Q9H4A3,Q7Z401,Q8TCB7 341 2.02e-02 653 4 2 0.500 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 Q9H4A3,Q13586 341 2.14e-02 114 4 2 0.500 0.018 HP:0003677 hp 1 Slow progression 1 Q9H4A3,Q13586 341 2.19e-02 7 4 1 0.250 0.143 GO:0034505 BP 1 tooth mineralization 1 Q13586 341 2.19e-02 7 4 1 0.250 0.143 GO:0097186 BP 1 amelogenesis 1 Q13586 341 2.19e-02 7 4 1 0.250 0.143 HP:0002661 hp 1 Painless fractures due to injury 1 Q9H4A3 341 2.19e-02 7 4 1 0.250 0.143 HP:0007460 hp 1 Autoamputation of digits 1 Q9H4A3 341 2.27e-02 788 4 3 0.750 0.004 TF:M00431_1 tf 1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 1 Q9H4A3,Q7Z401,Q8TCB7 341 2.50e-02 8 4 1 0.250 0.125 HP:0003738 hp 1 Exercise-induced myalgia 1 Q13586 341 2.50e-02 8 4 1 0.250 0.125 HP:0007021 hp 1 Pain insensitivity 1 Q9H4A3 341 2.50e-02 8 4 1 0.250 0.125 HP:0008242 hp 1 Pseudohypoaldosteronism 1 Q9H4A3 341 2.50e-02 8 4 1 0.250 0.125 GO:0002115 BP 1 store-operated calcium entry 1 Q13586 341 2.52e-02 733 4 2 0.500 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q9H4A3,Q13586 341 2.62e-02 2288 4 4 1.000 0.002 TF:M00919_0 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 0 1 Q9H4A3,Q13586,Q7Z401,Q8TCB7 341 2.76e-02 2317 4 4 1.000 0.002 TF:M00920_0 tf 1 Factor: E2F; motif: NKCGCGCSAAAN; match class: 0 1 Q9H4A3,Q13586,Q7Z401,Q8TCB7 341 2.81e-02 9 4 1 0.250 0.111 HP:0001842 hp 1 Foot acroosteolysis 1 Q9H4A3 341 2.81e-02 9 4 1 0.250 0.111 HP:0010177 hp 1 Osteolytic defects of the phalanges of the toes 1 Q9H4A3 341 2.82e-02 9 4 1 0.250 0.111 GO:0019869 MF 1 chloride channel inhibitor activity 1 Q9H4A3 341 2.82e-02 9 4 1 0.250 0.111 GO:0051010 MF 1 microtubule plus-end binding 1 Q13586 341 3.12e-02 10 4 1 0.250 0.100 HP:0001818 hp 1 Paronychia 1 Q9H4A3 341 3.12e-02 10 4 1 0.250 0.100 HP:0003750 hp 1 Increased muscle fatiguability 1 Q13586 341 3.36e-02 144 4 2 0.500 0.014 HP:0010929 hp 1 Abnormality of cation homeostasis 1 Q9H4A3,Q13586 341 3.52e-02 2462 4 4 1.000 0.002 TF:M00939_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 Q9H4A3,Q13586,Q7Z401,Q8TCB7 341 3.75e-02 12 4 1 0.250 0.083 HP:0009134 hp 1 Osteolysis involving bones of the feet 1 Q9H4A3 341 3.75e-02 12 4 1 0.250 0.083 HP:0100803 hp 1 Abnormality of the periungual region 1 Q9H4A3 341 3.75e-02 12 4 1 0.250 0.083 HP:0001218 hp 1 Autoamputation 1 Q9H4A3 341 3.75e-02 12 4 1 0.250 0.083 HP:0002401 hp 1 Stroke-like episodes 1 Q13586 341 3.75e-02 12 4 1 0.250 0.083 HP:0009139 hp 1 Osteolysis involving bones of the lower limbs 1 Q9H4A3 341 4.04e-02 21 4 1 0.250 0.048 REAC:418360 rea 1 Platelet calcium homeostasis 1 Q13586 341 4.06e-02 13 4 1 0.250 0.077 HP:0002600 hp 1 Hyporeflexia of lower limbs 1 Q13586 341 4.06e-02 13 4 1 0.250 0.077 HP:0040132 hp 1 Abnormal sensory nerve conduction velocity 1 Q9H4A3 341 4.06e-02 13 4 1 0.250 0.077 HP:0003448 hp 1 Decreased sensory nerve conduction velocity 1 Q9H4A3 341 4.06e-02 13 4 1 0.250 0.077 GO:1901021 BP 1 positive regulation of calcium ion transmembrane transporter activity 1 Q13586 341 4.06e-02 13 4 1 0.250 0.077 GO:0017081 MF 1 chloride channel regulator activity 1 Q9H4A3 341 4.06e-02 13 4 1 0.250 0.077 GO:0071782 CC 1 endoplasmic reticulum tubular network 1 Q13586 341 4.32e-02 164 4 2 0.500 0.012 HP:0003111 hp 1 Abnormality of ion homeostasis 1 Q9H4A3,Q13586 341 4.36e-02 14 4 1 0.250 0.071 HP:0011422 hp 1 Abnormality of chloride homeostasis 1 Q9H4A3 341 4.36e-02 14 4 1 0.250 0.071 HP:0000616 hp 1 Miosis 1 Q13586 341 4.36e-02 14 4 1 0.250 0.071 HP:0003554 hp 1 Type 2 muscle fiber atrophy 1 Q13586 341 4.67e-02 346 4 2 0.500 0.006 GO:0030001 BP 1 metal ion transport 1 Q9H4A3,Q13586 341 4.67e-02 15 4 1 0.250 0.067 HP:0002522 hp 1 Areflexia of lower limbs 1 Q13586 341 4.67e-02 15 4 1 0.250 0.067 HP:0001954 hp 1 Episodic fever 1 Q13586 341 4.69e-02 15 4 1 0.250 0.067 GO:0098827 CC 1 endoplasmic reticulum subcompartment 1 Q13586 341 4.69e-02 15 4 1 0.250 0.067 GO:0042475 BP 1 odontogenesis of dentin-containing tooth 1 Q13586 341 4.70e-02 347 4 2 0.500 0.006 GO:0050801 BP 1 ion homeostasis 1 Q9H4A3,Q13586 341 4.98e-02 16 4 1 0.250 0.062 HP:0003552 hp 1 Muscle stiffness 1 Q13586 341 4.98e-02 16 4 1 0.250 0.062 HP:0002153 hp 1 Hyperkalemia 1 Q9H4A3 341 5.00e-02 2 4 1 0.250 0.500 CORUM:1121 cor 1 WNK1-OSR1 complex 1 Q9H4A3 341 5.00e-02 2 4 1 0.250 0.500 CORUM:1123 cor 1 WNK1-SPAk complex 1 Q9H4A3 341 5.00e-02 177 4 2 0.500 0.011 HP:0001284 hp 1 Areflexia 1 Q9H4A3,Q13586 341 5.00e-02 235 4 2 0.500 0.009 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 Q9H4A3,Q13586 341 5.00e-02 26 4 1 0.250 0.038 REAC:983695 rea 1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1 Q13586 341 5.00e-02 16 4 1 0.250 0.062 GO:2001259 BP 1 positive regulation of cation channel activity 1 Q13586 342 1.99e-03 1030 4 3 0.750 0.003 TF:M00123_0 tf 1 Factor: c-Myc:Max; motif: NANCACGTGNNW; match class: 0 1 Q14258,A1X283,P47224 342 4.27e-03 1338 4 3 0.750 0.002 TF:M07054_1 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 1 Q14258,P56211,P47224 342 5.89e-03 408 4 2 0.500 0.005 TF:M02002_0 tf 1 Factor: Evi-1; motif: TATCTTGTC; match class: 0 1 P56211,A1X283 342 6.58e-03 21 4 1 0.250 0.048 TF:M06250_0 tf 1 Factor: ZNF345; motif: NCGGGGTGYYGC; match class: 0 1 P56211 342 6.92e-03 443 4 2 0.500 0.005 TF:M07406_0 tf 1 Factor: SREBP-2; motif: RTGGGGTGAY; match class: 0 1 Q14258,A1X283 342 7.83e-03 25 4 1 0.250 0.040 TF:M06036_0 tf 1 Factor: ZNF264; motif: NGKTTCATCAGM; match class: 0 1 A1X283 342 9.18e-03 512 4 2 0.500 0.004 TF:M07405_0 tf 1 Factor: SREBP-1; motif: RTCACCCCAY; match class: 0 1 Q14258,A1X283 342 9.54e-03 1765 4 3 0.750 0.002 TF:M00280_1 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 1 1 Q14258,P56211,P47224 342 1.06e-02 551 4 2 0.500 0.004 TF:M00776_0 tf 1 Factor: SREBP; motif: VNNVTCACCCYA; match class: 0 1 Q14258,A1X283 342 1.13e-02 36 4 1 0.250 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 A1X283 342 1.17e-02 4185 4 4 1.000 0.001 TF:M03797_1 tf 1 Factor: Msx-2; motif: TWWTTGGDGABN; match class: 1 1 Q14258,P56211,A1X283,P47224 342 1.28e-02 41 4 1 0.250 0.024 TF:M00650_0 tf 1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 0 1 Q14258 342 1.31e-02 4307 4 4 1.000 0.001 TF:M00172_0 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 0 1 Q14258,P56211,A1X283,P47224 342 1.38e-02 44 4 1 0.250 0.023 TF:M06635_0 tf 1 Factor: znf607; motif: NCCTTGAAGGGM; match class: 0 1 Q14258 342 1.45e-02 4414 4 4 1.000 0.001 TF:M00188_0 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 0 1 Q14258,P56211,A1X283,P47224 342 1.47e-02 47 4 1 0.250 0.021 TF:M06484_0 tf 1 Factor: ZNF683; motif: TTCCYAAATGC; match class: 0 1 A1X283 342 1.50e-02 48 4 1 0.250 0.021 TF:M06043_0 tf 1 Factor: ZNF208; motif: NGGGGSTAATGM; match class: 0 1 P47224 342 1.69e-02 54 4 1 0.250 0.019 TF:M03884_1 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 1 1 Q14258 342 1.71e-02 4605 4 4 1.000 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q14258,P56211,A1X283,P47224 342 1.79e-02 722 4 2 0.500 0.003 TF:M00050_1 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 1 1 A1X283,P47224 342 1.95e-02 756 4 2 0.500 0.003 TF:M00425_1 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 1 1 P56211,A1X283 342 2.09e-02 67 4 1 0.250 0.015 TF:M06141_0 tf 1 Factor: ZNF708; motif: NGKGGAAAAGGW; match class: 0 1 Q14258 342 2.09e-02 67 4 1 0.250 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 A1X283 342 2.32e-02 4969 4 4 1.000 0.001 TF:M00746_1 tf 1 Factor: Elf-1; motif: RNWMBAGGAART; match class: 1 1 Q14258,P56211,A1X283,P47224 342 2.48e-02 2 4 1 0.250 0.500 GO:0045722 BP 1 positive regulation of gluconeogenesis 1 P56211 342 2.98e-02 944 4 2 0.500 0.002 TF:M00188_1 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 1 1 P56211,A1X283 342 3.01e-02 97 4 1 0.250 0.010 TF:M07420_1 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 1 1 P47224 342 3.04e-02 98 4 1 0.250 0.010 TF:M02219_1 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 1 P56211 342 3.31e-02 5431 4 4 1.000 0.001 TF:M01865_0 tf 1 Factor: BTEB3; motif: BNRNGGGAGGNGT; match class: 0 1 Q14258,P56211,A1X283,P47224 342 3.41e-02 110 4 1 0.250 0.009 TF:M02252_1 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 1 1 Q14258 342 3.78e-02 122 4 1 0.250 0.008 TF:M07092_0 tf 1 Factor: Fra-2; motif: NRRTGASTCAB; match class: 0 1 A1X283 342 3.82e-02 49 4 1 0.250 0.020 KEGG:04622 keg 1 RIG-I-like receptor signaling pathway 1 Q14258 342 4.04e-02 2932 4 3 0.750 0.001 TF:M02063_0 tf 1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 0 1 Q14258,A1X283,P47224 342 4.09e-02 5725 4 4 1.000 0.001 TF:M00280_0 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 0 1 Q14258,P56211,A1X283,P47224 342 4.12e-02 2952 4 3 0.750 0.001 TF:M00454_0 tf 1 Factor: MRF2; motif: AWSCACAATACNVA; match class: 0 1 P56211,A1X283,P47224 342 4.30e-02 139 4 1 0.250 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 Q14258 342 4.57e-02 148 4 1 0.250 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 P47224 342 4.78e-02 3114 4 3 0.750 0.001 TF:M03983_0 tf 1 Factor: ETV5; motif: NCCGGAWGYN; match class: 0 1 Q14258,A1X283,P47224 342 4.86e-02 1224 4 2 0.500 0.002 TF:M03996_0 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 0 1 Q14258,P56211 342 4.97e-02 4 4 1 0.250 0.250 GO:0016176 MF 1 superoxide-generating NADPH oxidase activator activity 1 A1X283 342 5.00e-02 828 4 3 0.750 0.004 GO:0098772 MF 1 molecular function regulator 1 P56211,A1X283,P47224 342 5.00e-02 2 4 1 0.250 0.500 CORUM:2717 cor 1 Ubiquitin E3 ligase (TRIM25, DDX58) 1 Q14258 342 5.00e-02 1 4 1 0.250 1.000 OMIM:249420 omi 1 FRANK-TER HAAR SYNDROME; FTHS;;TER HAAR SYNDROME;;BORRONE DERMATOCARDIOSKELETAL SYNDROME;;MELNICK-NEEDLES SYNDROME, AUTOSOMAL RECESSIVE, FORMERLY 1 A1X283 342 5.00e-02 1 4 1 0.250 1.000 HP:0008519 hp 1 Abnormality of the coccyx 1 A1X283 342 5.00e-02 1 4 1 0.250 1.000 HP:0040016 hp 1 Prominent coccyx 1 A1X283 342 5.00e-02 10 4 1 0.250 0.100 REAC:918233 rea 1 TRAF3-dependent IRF activation pathway 1 Q14258 342 5.00e-02 10 4 1 0.250 0.100 REAC:2465910 rea 1 MASTL Facilitates Mitotic Progression 1 P56211 342 5.00e-02 1 4 1 0.250 1.000 HP:0008473 hp 1 Narrow anterio-posterior vertebral body diameter 1 A1X283 343 3.78e-08 59 6 4 0.667 0.068 GO:0044420 CC 1 extracellular matrix component 1 Q14766,Q9UBX5,P35555,O00468 343 4.76e-07 110 6 4 0.667 0.036 GO:0005578 CC 1 proteinaceous extracellular matrix 1 Q14766,Q9UBX5,P35555,O00468 343 2.01e-06 27 6 3 0.500 0.111 REAC:1566948 rea 1 Elastic fibre formation 1 Q14766,Q9UBX5,P35555 343 2.78e-06 3 6 2 0.333 0.667 GO:0035583 BP 1 sequestering of TGFbeta in extracellular matrix 1 Q14766,P35555 343 5.57e-06 4 6 2 0.333 0.500 GO:0071694 BP 1 maintenance of protein location in extracellular region 1 Q14766,P35555 343 5.57e-06 4 6 2 0.333 0.500 GO:0071692 BP 1 protein localization to extracellular region 1 Q14766,P35555 343 5.57e-06 4 6 2 0.333 0.500 GO:0035581 BP 1 sequestering of extracellular ligand from receptor 1 Q14766,P35555 343 9.27e-06 5 6 2 0.333 0.400 GO:1900115 BP 1 extracellular regulation of signal transduction 1 Q14766,P35555 343 9.27e-06 5 6 2 0.333 0.400 GO:1900116 BP 1 extracellular negative regulation of signal transduction 1 Q14766,P35555 343 1.39e-05 6 6 2 0.333 0.333 GO:0001527 CC 1 microfibril 1 Q14766,P35555 343 1.44e-05 257 6 4 0.667 0.016 GO:0031012 CC 1 extracellular matrix 1 Q14766,Q9UBX5,P35555,O00468 343 2.59e-05 8 6 2 0.333 0.250 GO:0043205 CC 1 fibril 1 Q14766,P35555 343 2.99e-05 228 6 4 0.667 0.018 REAC:1474244 rea 1 Extracellular matrix organization 1 Q14766,Q9UBX5,P35555,O00468 343 1.90e-04 18 6 2 0.333 0.111 REAC:2129379 rea 1 Molecules associated with elastic fibres 1 Q14766,Q9UBX5 343 2.97e-04 2 6 2 0.333 1.000 HP:0004927 hp 1 Pulmonary artery dilatation 1 Q9UBX5,P35555 343 4.31e-04 204 6 3 0.500 0.015 GO:0030198 BP 1 extracellular matrix organization 1 Q9UBX5,P35555,O00468 343 4.31e-04 204 6 3 0.500 0.015 GO:0043062 BP 1 extracellular structure organization 1 Q9UBX5,P35555,O00468 343 5.48e-04 35 6 2 0.333 0.057 GO:0005604 CC 1 basement membrane 1 P35555,O00468 343 6.47e-04 38 6 2 0.333 0.053 GO:1903845 BP 1 negative regulation of cellular response to transforming growth factor beta stimulus 1 Q14766,P35555 343 6.47e-04 38 6 2 0.333 0.053 GO:0030512 BP 1 negative regulation of transforming growth factor beta receptor signaling pathway 1 Q14766,P35555 343 6.51e-04 33 6 2 0.333 0.061 REAC:975634 rea 1 Retinoid metabolism and transport 1 P01130,O00468 343 1.01e-03 41 6 2 0.333 0.049 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 P01130,O00468 343 1.18e-03 1618 6 5 0.833 0.003 GO:0033036 BP 1 macromolecule localization 1 Q14766,P01130,Q9UBX5,P35555,O00468 343 1.31e-03 54 6 2 0.333 0.037 GO:0005178 MF 1 integrin binding 1 Q9UBX5,P35555 343 1.31e-03 54 6 2 0.333 0.037 GO:0090101 BP 1 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q14766,P35555 343 1.40e-03 2478 6 5 0.833 0.002 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q14766,P01130,Q9UBX5,O00468,Q9H3C7 343 1.56e-03 51 6 2 0.333 0.039 REAC:216083 rea 1 Integrin cell surface interactions 1 P35555,O00468 343 1.57e-03 59 6 2 0.333 0.034 GO:0017015 BP 1 regulation of transforming growth factor beta receptor signaling pathway 1 Q14766,P35555 343 1.57e-03 59 6 2 0.333 0.034 GO:1903844 BP 1 regulation of cellular response to transforming growth factor beta stimulus 1 Q14766,P35555 343 1.59e-03 567 6 3 0.500 0.005 TF:M05876_0 tf 1 Factor: ZNF526; motif: KGGGTGGGGWRC; match class: 0 1 Q14766,Q9UBX5,O00468 343 1.68e-03 61 6 2 0.333 0.033 GO:0001948 MF 1 glycoprotein binding 1 P01130,O00468 343 1.79e-03 63 6 2 0.333 0.032 GO:0090288 BP 1 negative regulation of cellular response to growth factor stimulus 1 Q14766,P35555 343 2.14e-03 1 6 1 0.167 1.000 GO:0048050 BP 1 post-embryonic eye morphogenesis 1 P35555 343 2.14e-03 1 6 1 0.167 1.000 GO:0045887 BP 1 positive regulation of synaptic growth at neuromuscular junction 1 O00468 343 2.14e-03 1 6 1 0.167 1.000 GO:1904398 BP 1 positive regulation of neuromuscular junction development 1 O00468 343 2.14e-03 1 6 1 0.167 1.000 GO:0050436 MF 1 microfibril binding 1 Q14766 343 2.14e-03 1 6 1 0.167 1.000 GO:0009886 BP 1 post-embryonic animal morphogenesis 1 P35555 343 2.14e-03 1 6 1 0.167 1.000 GO:0048563 BP 1 post-embryonic animal organ morphogenesis 1 P35555 343 2.31e-03 62 6 2 0.333 0.032 REAC:2187338 rea 1 Visual phototransduction 1 P01130,O00468 343 2.40e-03 73 6 2 0.333 0.027 GO:0045185 BP 1 maintenance of protein location 1 Q14766,P35555 343 2.75e-03 176 6 2 0.333 0.011 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 P35555,Q9H3C7 343 2.83e-03 6 6 1 0.167 0.167 TF:M05752_1 tf 1 Factor: ZNF57; motif: NCGGGGTGGKSA; match class: 1 1 P35555 343 3.17e-03 84 6 2 0.333 0.024 GO:0005539 MF 1 glycosaminoglycan binding 1 P35555,O00468 343 3.34e-03 2970 6 5 0.833 0.002 TF:M03558_0 tf 1 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN; match class: 0 1 P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 4.21e-03 1 6 1 0.167 1.000 OMIM:614185 omi 1 GELEOPHYSIC DYSPLASIA 2; GPHYSD2 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:184900 omi 1 STIFF SKIN SYNDROME; SSKS 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:615120 omi 1 MYASTHENIC SYNDROME, CONGENITAL, 8; CMS8;;MYASTHENIC SYNDROME, CONGENITAL, WITH PRE- AND POSTSYNAPTIC DEFECTS;CMSPPD;;MYASTHENIC SYNDROME, CONGENITAL, DUE TO AGRIN DEFICIENCY 1 O00468 343 4.21e-03 1 6 1 0.167 1.000 OMIM:102370 omi 1 ACROMICRIC DYSPLASIA; ACMICD 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:608328 omi 1 WEILL-MARCHESANI SYNDROME 2; WMS2;;WEILL-MARCHESANI SYNDROME, AUTOSOMAL DOMINANT;;SPHEROPHAKIA-BRACHYMORPHIA SYNDROME;;MESODERMAL DYSMORPHODYSTROPHY, CONGENITAL;;GLAUCOMA-LENS ECTOPIA-MICROSPHEROPHAKIA-STIFFNESS-SHORTNESS SYNDROME;GEMSS 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:614434 omi 1 CUTIS LAXA, AUTOSOMAL DOMINANT 2; ADCL2 1 Q9UBX5 343 4.21e-03 1 6 1 0.167 1.000 OMIM:604308 omi 1 MASS SYNDROME;;MASS PHENOTYPE;;OVERLAP CONNECTIVE TISSUE DISEASE; OCTD 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:608895 omi 1 MACULAR DEGENERATION, AGE-RELATED, 3; ARMD3 1 Q9UBX5 343 4.21e-03 1 6 1 0.167 1.000 OMIM:154700 omi 1 MARFAN SYNDROME; MFS;;MARFAN SYNDROME, TYPE I; MFS1 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:231050 omi 1 Geleophysic Dysplasia 1 P35555 343 4.21e-03 1 6 1 0.167 1.000 OMIM:129600 omi 1 Isolated Ectopia Lentis 1 P35555 343 4.28e-03 2 6 1 0.167 0.500 GO:0008582 BP 1 regulation of synaptic growth at neuromuscular junction 1 O00468 343 4.28e-03 2 6 1 0.167 0.500 GO:1990666 CC 1 PCSK9-LDLR complex 1 P01130 343 4.28e-03 2 6 1 0.167 0.500 GO:2001205 BP 1 negative regulation of osteoclast development 1 P35555 343 4.28e-03 2 6 1 0.167 0.500 GO:1903011 BP 1 negative regulation of bone development 1 P35555 343 4.28e-03 2 6 1 0.167 0.500 GO:0035582 BP 1 sequestering of BMP in extracellular matrix 1 P35555 343 4.28e-03 2 6 1 0.167 0.500 GO:0010899 BP 1 regulation of phosphatidylcholine catabolic process 1 P01130 343 5.23e-03 108 6 2 0.333 0.019 GO:0007179 BP 1 transforming growth factor beta receptor signaling pathway 1 Q14766,P35555 343 5.33e-03 109 6 2 0.333 0.018 GO:1901681 MF 1 sulfur compound binding 1 P35555,O00468 343 5.52e-03 111 6 2 0.333 0.018 GO:0090092 BP 1 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q14766,P35555 343 5.64e-03 12 6 1 0.167 0.083 TF:M06148_0 tf 1 Factor: ZNF41; motif: NAKTAAGAGARA; match class: 0 1 Q14766 343 5.67e-03 3321 6 5 0.833 0.002 TF:M00084_1 tf 1 Factor: MZF-1; motif: KNGNKAGGGGNAA; match class: 1 1 Q14766,Q9UBX5,P35555,O00468,Q9H3C7 343 5.93e-03 115 6 2 0.333 0.017 GO:0090287 BP 1 regulation of cellular response to growth factor stimulus 1 Q14766,P35555 343 6.42e-03 3 6 1 0.167 0.333 GO:0071953 CC 1 elastic fiber 1 Q9UBX5 343 6.42e-03 3 6 1 0.167 0.333 GO:0060696 BP 1 regulation of phospholipid catabolic process 1 P01130 343 6.42e-03 3 6 1 0.167 0.333 GO:1904396 BP 1 regulation of neuromuscular junction development 1 O00468 343 6.42e-03 3 6 1 0.167 0.333 GO:0045162 BP 1 clustering of voltage-gated sodium channels 1 O00468 343 6.42e-03 3 6 1 0.167 0.333 GO:0048569 BP 1 post-embryonic animal organ development 1 P35555 343 6.42e-03 3 6 1 0.167 0.333 GO:2001204 BP 1 regulation of osteoclast development 1 P35555 343 6.42e-03 3 6 1 0.167 0.333 GO:0051124 BP 1 synaptic growth at neuromuscular junction 1 O00468 343 6.42e-03 3 6 1 0.167 0.333 GO:0035374 MF 1 chondroitin sulfate binding 1 O00468 343 6.48e-03 925 6 3 0.500 0.003 TF:M01587_1 tf 1 Factor: FPM315; motif: SRGGGAGGAGGN; match class: 1 1 Q14766,O00468,Q9H3C7 343 7.33e-03 128 6 2 0.333 0.016 GO:0071560 BP 1 cellular response to transforming growth factor beta stimulus 1 Q14766,P35555 343 7.44e-03 129 6 2 0.333 0.016 GO:0071559 BP 1 response to transforming growth factor beta 1 Q14766,P35555 343 7.55e-03 540 6 3 0.500 0.006 GO:0097367 MF 1 carbohydrate derivative binding 1 P01130,P35555,O00468 343 8.42e-03 2 6 1 0.167 0.500 OMIM:123700 omi 1 Autosomal Dominant Cutis Laxa 1 Q9UBX5 343 8.46e-03 18 6 1 0.167 0.056 TF:M05507_0 tf 1 Factor: Aiolos; motif: NGGGGGGGGMGTK; match class: 0 1 O00468 343 8.56e-03 4 6 1 0.167 0.250 GO:1903010 BP 1 regulation of bone development 1 P35555 343 8.56e-03 4 6 1 0.167 0.250 GO:0032050 MF 1 clathrin heavy chain binding 1 P01130 343 8.56e-03 4 6 1 0.167 0.250 GO:0030229 MF 1 very-low-density lipoprotein particle receptor activity 1 P01130 343 8.79e-03 319 6 2 0.333 0.006 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q14766,P01130 343 8.92e-03 1036 6 3 0.500 0.003 TF:M01132_0 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 0 1 P01130,P35555,Q9H3C7 343 8.92e-03 1036 6 3 0.500 0.003 TF:M07253_0 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 0 1 P01130,P35555,Q9H3C7 343 8.93e-03 19 6 1 0.167 0.053 TF:M05628_0 tf 1 Factor: ZNF735; motif: NGGTCCGGCCSC; match class: 0 1 Q14766 343 9.38e-03 126 6 2 0.333 0.016 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P01130,O00468 343 9.86e-03 21 6 1 0.167 0.048 TF:M06521_0 tf 1 Factor: ZFP62; motif: NGGTSCMGCCGG; match class: 0 1 P35555 343 1.06e-02 9 6 2 0.333 0.222 HP:0004937 hp 1 Pulmonary artery aneurysm 1 Q9UBX5,P35555 343 1.06e-02 9 6 2 0.333 0.222 HP:0004955 hp 1 Generalized arterial tortuosity 1 Q9UBX5,P35555 343 1.07e-02 1393 6 4 0.667 0.003 GO:0008104 BP 1 protein localization 1 Q14766,Q9UBX5,P35555,O00468 343 1.07e-02 5 6 1 0.167 0.200 GO:0034638 BP 1 phosphatidylcholine catabolic process 1 P01130 343 1.07e-02 5 6 1 0.167 0.200 GO:0033691 MF 1 sialic acid binding 1 O00468 343 1.07e-02 5 6 1 0.167 0.200 GO:0048251 BP 1 elastic fiber assembly 1 Q9UBX5 343 1.07e-02 5 6 1 0.167 0.200 GO:0030023 MF 1 extracellular matrix constituent conferring elasticity 1 P35555 343 1.08e-02 23 6 1 0.167 0.043 TF:M05478_0 tf 1 Factor: ZFP202; motif: NTGGGTAGCWAM; match class: 0 1 Q9UBX5 343 1.16e-02 1423 6 4 0.667 0.003 GO:0070887 BP 1 cellular response to chemical stimulus 1 Q14766,Q9UBX5,P35555,O00468 343 1.22e-02 26 6 1 0.167 0.038 TF:M06990_0 tf 1 Factor: ZNF236; motif: GCCAWTATTGKT; match class: 0 1 Q14766 343 1.28e-02 6 6 1 0.167 0.167 GO:0045671 BP 1 negative regulation of osteoclast differentiation 1 P35555 343 1.28e-02 6 6 1 0.167 0.167 GO:0036035 BP 1 osteoclast development 1 P35555 343 1.28e-02 6 6 1 0.167 0.167 GO:0005024 MF 1 transforming growth factor beta-activated receptor activity 1 Q14766 343 1.28e-02 6 6 1 0.167 0.167 GO:0002162 MF 1 dystroglycan binding 1 O00468 343 1.28e-02 6 6 1 0.167 0.167 GO:0097493 MF 1 structural molecule activity conferring elasticity 1 P35555 343 1.34e-02 174 6 2 0.333 0.011 GO:0007178 BP 1 transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q14766,P35555 343 1.35e-02 398 6 2 0.333 0.005 TF:M02107_0 tf 1 Factor: NF-YC; motif: NRGCCAATYAGMGC; match class: 0 1 O00468,Q9H3C7 343 1.38e-02 403 6 2 0.333 0.005 TF:M00947_1 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 1 1 P01130,O00468 343 1.47e-02 182 6 2 0.333 0.011 GO:0051235 BP 1 maintenance of location 1 Q14766,P35555 343 1.49e-02 420 6 2 0.333 0.005 TF:M05752_0 tf 1 Factor: ZNF57; motif: NCGGGGTGGKSA; match class: 0 1 P35555,O00468 343 1.50e-02 7 6 1 0.167 0.143 GO:0010867 BP 1 positive regulation of triglyceride biosynthetic process 1 P01130 343 1.50e-02 7 6 1 0.167 0.143 GO:0043395 MF 1 heparan sulfate proteoglycan binding 1 O00468 343 1.50e-02 7 6 1 0.167 0.143 GO:2000121 BP 1 regulation of removal of superoxide radicals 1 Q9UBX5 343 1.50e-02 2461 6 4 0.667 0.002 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q14766,P01130,P35555,O00468 343 1.50e-02 32 6 1 0.167 0.031 TF:M05999_0 tf 1 Factor: ZNF711; motif: WGTTTAAACCC; match class: 0 1 Q9UBX5 343 1.53e-02 186 6 2 0.333 0.011 GO:0005509 MF 1 calcium ion binding 1 P35555,O00468 343 1.61e-02 6396 6 6 1.000 0.001 TF:M07387_0 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 0 1 Q14766,P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 1.62e-02 11 6 2 0.333 0.182 HP:0001548 hp 1 Overgrowth 1 Q9UBX5,P35555 343 1.65e-02 389 6 2 0.333 0.005 MI:rno-miR-347 mi 1 MI:rno-miR-347 1 P01130,O00468 343 1.66e-02 6427 6 6 1.000 0.001 TF:M07250_1 tf 1 Factor: E2F1; motif: NNNSSCGCSAANN; match class: 1 1 Q14766,P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 1.71e-02 451 6 2 0.333 0.004 TF:M04182_1 tf 1 Factor: NEUROD2; motif: RMCATATGKY; match class: 1 1 Q14766,Q9UBX5 343 1.71e-02 8 6 1 0.167 0.125 GO:0045161 BP 1 neuronal ion channel clustering 1 O00468 343 1.71e-02 8 6 1 0.167 0.125 GO:0070508 BP 1 cholesterol import 1 P01130 343 1.71e-02 8 6 1 0.167 0.125 GO:0005041 MF 1 low-density lipoprotein receptor activity 1 P01130 343 1.71e-02 8 6 1 0.167 0.125 GO:0098856 BP 1 intestinal lipid absorption 1 P01130 343 1.71e-02 8 6 1 0.167 0.125 GO:0030299 BP 1 intestinal cholesterol absorption 1 P01130 343 1.71e-02 8 6 1 0.167 0.125 GO:0035376 BP 1 sterol import 1 P01130 343 1.71e-02 8 6 1 0.167 0.125 GO:0098751 BP 1 bone cell development 1 P35555 343 1.73e-02 37 6 1 0.167 0.027 TF:M06558_0 tf 1 Factor: ZNF675; motif: NGGGAAAAAASA; match class: 0 1 P01130 343 1.73e-02 37 6 1 0.167 0.027 TF:M06620_0 tf 1 Factor: ZNF681; motif: NGGGAAAAAASA; match class: 0 1 P01130 343 1.78e-02 38 6 1 0.167 0.026 TF:M07093_0 tf 1 Factor: FoxH1; motif: NNSAATCCACA; match class: 0 1 Q14766 343 1.84e-02 2605 6 4 0.667 0.002 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 Q14766,P01130,Q9UBX5,Q9H3C7 343 1.92e-02 9 6 1 0.167 0.111 GO:0009791 BP 1 post-embryonic development 1 P35555 343 1.92e-02 9 6 1 0.167 0.111 GO:0005605 CC 1 basal lamina 1 O00468 343 1.92e-02 9 6 1 0.167 0.111 GO:1905145 BP 1 cellular response to acetylcholine 1 O00468 343 1.92e-02 9 6 1 0.167 0.111 GO:0090208 BP 1 positive regulation of triglyceride metabolic process 1 P01130 343 1.92e-02 9 6 1 0.167 0.111 GO:0095500 BP 1 acetylcholine receptor signaling pathway 1 O00468 343 1.92e-02 9 6 1 0.167 0.111 GO:1903831 BP 1 signal transduction involved in cellular response to ammonium ion 1 O00468 343 1.92e-02 9 6 1 0.167 0.111 GO:0007213 BP 1 G-protein coupled acetylcholine receptor signaling pathway 1 O00468 343 1.92e-02 9 6 1 0.167 0.111 GO:1905144 BP 1 response to acetylcholine 1 O00468 343 1.94e-02 12 6 2 0.333 0.167 HP:0002631 hp 1 Ascending aortic aneurysm 1 Q9UBX5,P35555 343 1.94e-02 12 6 2 0.333 0.167 HP:0012727 hp 1 Thoracic aortic aneurysm 1 Q9UBX5,P35555 343 1.98e-02 11 6 1 0.167 0.091 REAC:3656253 rea 1 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 1 O00468 343 1.98e-02 11 6 1 0.167 0.091 REAC:3656237 rea 1 Defective EXT2 causes exostoses 2 1 O00468 343 2.10e-02 5 6 1 0.167 0.200 OMIM:219100 omi 1 Autosomal Recessive Cutis Laxa 1 Q9UBX5 343 2.10e-02 5 6 1 0.167 0.200 OMIM:143890 omi 1 HYPERCHOLESTEROLEMIA, FAMILIAL;;FHC; FH;;HYPERLIPOPROTEINEMIA, TYPE II;;HYPERLIPOPROTEINEMIA, TYPE IIA;;HYPER-LOW-DENSITY-LIPOPROTEINEMIA;;HYPERCHOLESTEROLEMIC XANTHOMATOSIS, FAMILIAL;;LDL RECEPTOR DISORDERLOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS2, INCLUDED; LDLCQ2, INCLUDED 1 P01130 343 2.13e-02 4411 6 5 0.833 0.001 TF:M00302_0 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 0 1 Q14766,P01130,Q9UBX5,P35555,Q9H3C7 343 2.14e-02 10 6 1 0.167 0.100 GO:0030228 MF 1 lipoprotein particle receptor activity 1 P01130 343 2.14e-02 10 6 1 0.167 0.100 GO:0048048 BP 1 embryonic eye morphogenesis 1 P35555 343 2.14e-02 10 6 1 0.167 0.100 GO:0034383 BP 1 low-density lipoprotein particle clearance 1 P01130 343 2.15e-02 46 6 1 0.167 0.022 TF:M06064_0 tf 1 Factor: ZNF729; motif: NGTTGGGAAAGM; match class: 0 1 P01130 343 2.18e-02 451 6 2 0.333 0.004 MI:hsa-miR-892b mi 1 MI:hsa-miR-892b 1 Q9UBX5,O00468 343 2.21e-02 2740 6 4 0.667 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q14766,P01130,Q9UBX5,Q9H3C7 343 2.28e-02 525 6 2 0.333 0.004 TF:M07140_0 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 0 1 P35555,Q9H3C7 343 2.29e-02 13 6 2 0.333 0.154 HP:0005112 hp 1 Dilatation of the abdominal aorta 1 Q9UBX5,P35555 343 2.29e-02 13 6 2 0.333 0.154 HP:0004942 hp 1 Aortic aneurysm 1 Q9UBX5,P35555 343 2.35e-02 11 6 1 0.167 0.091 GO:0010866 BP 1 regulation of triglyceride biosynthetic process 1 P01130 343 2.38e-02 473 6 2 0.333 0.004 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 P01130,P35555 343 2.41e-02 541 6 2 0.333 0.004 TF:M05544_0 tf 1 Factor: BCL-11A; motif: CSTAMGGA; match class: 0 1 P01130,Q9H3C7 343 2.43e-02 478 6 2 0.333 0.004 MI:hsa-miR-9 mi 1 MI:hsa-miR-9 1 P01130,P35555 343 2.56e-02 12 6 1 0.167 0.083 GO:0061515 BP 1 myeloid cell development 1 P35555 343 2.56e-02 12 6 1 0.167 0.083 GO:0044241 BP 1 lipid digestion 1 P01130 343 2.56e-02 12 6 1 0.167 0.083 GO:0051965 BP 1 positive regulation of synapse assembly 1 O00468 343 2.57e-02 55 6 1 0.167 0.018 TF:M06393_0 tf 1 Factor: ZNF765; motif: NTGGYAAGGRSA; match class: 0 1 Q9UBX5 343 2.64e-02 499 6 2 0.333 0.004 MI:hsa-miR-128a mi 1 MI:hsa-miR-128a 1 P01130,O00468 343 2.68e-02 2893 6 4 0.667 0.001 TF:M04617_1 tf 1 Factor: LRF; motif: NGNAGNGGGTYN; match class: 1 1 Q14766,P35555,O00468,Q9H3C7 343 2.69e-02 15 6 1 0.167 0.067 REAC:171052 rea 1 LDL-mediated lipid transport 1 P01130 343 2.74e-02 2909 6 4 0.667 0.001 TF:M04435_0 tf 1 Factor: RAX; motif: NNYAATTANN; match class: 0 1 Q14766,P01130,Q9UBX5,Q9H3C7 343 2.76e-02 6998 6 6 1.000 0.001 TF:M07301_0 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 0 1 Q14766,P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 2.78e-02 13 6 1 0.167 0.077 GO:0071451 BP 1 cellular response to superoxide 1 Q9UBX5 343 2.78e-02 13 6 1 0.167 0.077 GO:0019430 BP 1 removal of superoxide radicals 1 Q9UBX5 343 2.78e-02 13 6 1 0.167 0.077 GO:0046475 BP 1 glycerophospholipid catabolic process 1 P01130 343 2.78e-02 13 6 1 0.167 0.077 GO:0007528 BP 1 neuromuscular junction development 1 O00468 343 2.78e-02 13 6 1 0.167 0.077 GO:0000303 BP 1 response to superoxide 1 Q9UBX5 343 2.78e-02 13 6 1 0.167 0.077 GO:0071450 BP 1 cellular response to oxygen radical 1 Q9UBX5 343 2.84e-02 61 6 1 0.167 0.016 TF:M00766_0 tf 1 Factor: LXR; motif: TGACCGNNAGTRACCC; match class: 0 1 Q9H3C7 343 2.86e-02 592 6 2 0.333 0.003 TF:M00174_1 tf 1 Factor: AP-1; motif: NNTGACTCANN; match class: 1 1 P01130,O00468 343 2.99e-02 14 6 1 0.167 0.071 GO:0050431 MF 1 transforming growth factor beta binding 1 Q14766 343 2.99e-02 14 6 1 0.167 0.071 GO:0000305 BP 1 response to oxygen radical 1 Q9UBX5 343 2.99e-02 14 6 1 0.167 0.071 GO:0002762 BP 1 negative regulation of myeloid leukocyte differentiation 1 P35555 343 2.99e-02 14 6 1 0.167 0.071 GO:0050892 BP 1 intestinal absorption 1 P01130 343 2.99e-02 14 6 1 0.167 0.071 GO:0004675 MF 1 transmembrane receptor protein serine/threonine kinase activity 1 Q14766 343 2.99e-02 14 6 1 0.167 0.071 GO:0090322 BP 1 regulation of superoxide metabolic process 1 Q9UBX5 343 3.05e-02 17 6 1 0.167 0.059 REAC:174800 rea 1 Chylomicron-mediated lipid transport 1 P01130 343 3.05e-02 17 6 1 0.167 0.059 REAC:3560783 rea 1 Defective B4GALT7 causes EDS, progeroid type 1 O00468 343 3.05e-02 17 6 1 0.167 0.059 REAC:3560801 rea 1 Defective B3GAT3 causes JDSSDHD 1 O00468 343 3.05e-02 17 6 1 0.167 0.059 REAC:4420332 rea 1 Defective B3GALT6 causes EDSP2 and SEMDJL1 1 O00468 343 3.08e-02 266 6 2 0.333 0.008 GO:1901565 BP 1 organonitrogen compound catabolic process 1 P01130,O00468 343 3.16e-02 68 6 1 0.167 0.015 TF:M05727_0 tf 1 Factor: ZNF674; motif: NGTTMAAAAAWA; match class: 0 1 P01130 343 3.16e-02 68 6 1 0.167 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 P01130 343 3.17e-02 531 6 2 0.333 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q14766,P35555 343 3.20e-02 15 6 1 0.167 0.067 GO:0034381 BP 1 plasma lipoprotein particle clearance 1 P01130 343 3.20e-02 15 6 1 0.167 0.067 GO:0043236 MF 1 laminin binding 1 O00468 343 3.20e-02 15 6 1 0.167 0.067 GO:0098869 BP 1 cellular oxidant detoxification 1 Q9UBX5 343 3.20e-02 15 6 1 0.167 0.067 GO:0051491 BP 1 positive regulation of filopodium assembly 1 O00468 343 3.20e-02 15 6 1 0.167 0.067 GO:0042551 BP 1 neuron maturation 1 O00468 343 3.20e-02 15 6 1 0.167 0.067 GO:0090207 BP 1 regulation of triglyceride metabolic process 1 P01130 343 3.23e-02 18 6 1 0.167 0.056 REAC:2024096 rea 1 HS-GAG degradation 1 O00468 343 3.26e-02 274 6 2 0.333 0.007 GO:0099512 CC 1 supramolecular fiber 1 Q14766,P35555 343 3.26e-02 274 6 2 0.333 0.007 GO:0099081 CC 1 supramolecular polymer 1 Q14766,P35555 343 3.29e-02 1665 6 3 0.500 0.002 TF:M01224_0 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 0 1 P01130,O00468,Q9H3C7 343 3.30e-02 1882 6 4 0.667 0.002 GO:0042221 BP 1 response to chemical 1 Q14766,Q9UBX5,P35555,O00468 343 3.41e-02 16 6 1 0.167 0.062 GO:0030514 BP 1 negative regulation of BMP signaling pathway 1 P35555 343 3.47e-02 657 6 2 0.333 0.003 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 P01130,O00468 343 3.54e-02 1712 6 3 0.500 0.002 TF:M04619_0 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 0 1 Q14766,P01130,Q9H3C7 343 3.58e-02 1924 6 4 0.667 0.002 GO:0065008 BP 1 regulation of biological quality 1 Q14766,P01130,P35555,O00468 343 3.59e-02 7311 6 6 1.000 0.001 TF:M00395_1 tf 1 Factor: HOXA3; motif: CNTANNNKN; match class: 1 1 Q14766,P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 3.63e-02 17 6 1 0.167 0.059 GO:0085029 BP 1 extracellular matrix assembly 1 Q9UBX5 343 3.63e-02 17 6 1 0.167 0.059 GO:0045670 BP 1 regulation of osteoclast differentiation 1 P35555 343 3.65e-02 3155 6 4 0.667 0.001 TF:M01253_0 tf 1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 0 1 Q14766,Q9UBX5,O00468,Q9H3C7 343 3.65e-02 3156 6 4 0.667 0.001 TF:M07041_1 tf 1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 1 Q14766,P01130,P35555,O00468 343 3.71e-02 80 6 1 0.167 0.013 TF:M07281_1 tf 1 Factor: EKLF; motif: NCCMCACCCW; match class: 1 1 O00468 343 3.73e-02 294 6 2 0.333 0.007 GO:0099080 CC 1 supramolecular complex 1 Q14766,P35555 343 3.75e-02 1748 6 3 0.500 0.002 TF:M07313_1 tf 1 Factor: ATF-3; motif: SNTGACGYNATN; match class: 1 1 Q14766,P01130,Q9H3C7 343 3.81e-02 7385 6 6 1.000 0.001 TF:M00033_1 tf 1 Factor: p300; motif: NNNGGGAGTNNNNS; match class: 1 1 Q14766,P01130,Q9UBX5,P35555,O00468,Q9H3C7 343 3.84e-02 18 6 1 0.167 0.056 GO:0051963 BP 1 regulation of synapse assembly 1 O00468 343 3.84e-02 18 6 1 0.167 0.056 GO:1990748 BP 1 cellular detoxification 1 Q9UBX5 343 3.85e-02 33 6 1 0.167 0.030 KEGG:04913 keg 1 Ovarian steroidogenesis 1 P01130 343 3.94e-02 22 6 1 0.167 0.045 REAC:3560782 rea 1 Diseases associated with glycosaminoglycan metabolism 1 O00468 343 3.94e-02 22 6 1 0.167 0.045 REAC:1971475 rea 1 A tetrasaccharide linker sequence is required for GAG synthesis 1 O00468 343 4.05e-02 19 6 1 0.167 0.053 GO:0009395 BP 1 phospholipid catabolic process 1 P01130 343 4.05e-02 19 6 1 0.167 0.053 GO:0071242 BP 1 cellular response to ammonium ion 1 O00468 343 4.05e-02 19 6 1 0.167 0.053 GO:0043394 MF 1 proteoglycan binding 1 O00468 343 4.14e-02 3401 6 5 0.833 0.001 GO:0051179 BP 1 localization 1 Q14766,P01130,Q9UBX5,P35555,O00468 343 4.26e-02 92 6 1 0.167 0.011 TF:M03991_0 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 0 1 P01130 343 4.26e-02 92 6 1 0.167 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 P35555 343 4.26e-02 20 6 1 0.167 0.050 GO:1901031 BP 1 regulation of response to reactive oxygen species 1 Q9UBX5 343 4.26e-02 20 6 1 0.167 0.050 GO:0098754 BP 1 detoxification 1 Q9UBX5 343 4.26e-02 20 6 1 0.167 0.050 GO:0038024 MF 1 cargo receptor activity 1 P01130 343 4.29e-02 24 6 1 0.167 0.042 REAC:419037 rea 1 NCAM1 interactions 1 O00468 343 4.29e-02 316 6 2 0.333 0.006 GO:0071363 BP 1 cellular response to growth factor stimulus 1 Q14766,P35555 343 4.42e-02 5180 6 5 0.833 0.001 TF:M03563_0 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 0 1 Q14766,Q9UBX5,P35555,O00468,Q9H3C7 343 4.49e-02 97 6 1 0.167 0.010 TF:M00068_0 tf 1 Factor: HEN1; motif: NNNGGNCNCAGCTGCGNCCCNN; match class: 0 1 Q9UBX5 343 4.56e-02 326 6 2 0.333 0.006 GO:0070848 BP 1 response to growth factor 1 Q14766,P35555 343 4.59e-02 11 6 1 0.167 0.091 OMIM:603075 omi 1 Age-Related Macular Degeneration 1 Q9UBX5 343 4.69e-02 22 6 1 0.167 0.045 GO:0050840 MF 1 extracellular matrix binding 1 O00468 343 4.74e-02 1621 6 3 0.500 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q14766,Q9UBX5,P35555 343 4.76e-02 103 6 1 0.167 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 P35555 343 4.90e-02 23 6 1 0.167 0.043 GO:0043113 BP 1 receptor clustering 1 O00468 343 4.90e-02 23 6 1 0.167 0.043 GO:0060359 BP 1 response to ammonium ion 1 O00468 343 4.94e-02 107 6 1 0.167 0.009 TF:M01007_0 tf 1 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN; match class: 0 1 P35555 343 4.99e-02 108 6 1 0.167 0.009 TF:M04165_0 tf 1 Factor: BHLHE23; motif: AMCATATGYT; match class: 0 1 Q9UBX5 343 4.99e-02 5322 6 5 0.833 0.001 TF:M00749_1 tf 1 Factor: SREBP-1; motif: CACSCCA; match class: 1 1 Q14766,P01130,Q9UBX5,P35555,O00468 343 5.00e-02 19 6 2 0.333 0.105 HP:0005116 hp 1 Arterial tortuosity 1 Q9UBX5,P35555 343 5.00e-02 342 6 2 0.333 0.006 GO:0005764 CC 1 lysosome 1 P01130,O00468 343 5.00e-02 28 6 1 0.167 0.036 REAC:2022928 rea 1 HS-GAG biosynthesis 1 O00468 343 5.00e-02 19 6 2 0.333 0.105 HP:0004948 hp 1 Vascular tortuosity 1 Q9UBX5,P35555 343 5.00e-02 342 6 2 0.333 0.006 GO:0000323 CC 1 lytic vacuole 1 P01130,O00468 344 4.22e-11 9 7 4 0.571 0.444 GO:0042407 BP 1 cristae formation 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 3.35e-10 14 7 4 0.571 0.286 GO:0007007 BP 1 inner mitochondrial membrane organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 9.67e-09 5 7 3 0.429 0.600 GO:0061617 CC 1 MICOS complex 1 Q9NX63,Q16891,Q9BRQ6 344 3.40e-07 72 7 4 0.571 0.056 GO:0007006 BP 1 mitochondrial membrane organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 7.86e-07 18 7 3 0.429 0.167 GO:0031305 CC 1 integral component of mitochondrial inner membrane 1 Q9NX63,Q16891,Q9BRQ6 344 9.33e-07 19 7 3 0.429 0.158 GO:0031304 CC 1 intrinsic component of mitochondrial inner membrane 1 Q9NX63,Q16891,Q9BRQ6 344 1.96e-06 111 7 4 0.571 0.036 GO:0098798 CC 1 mitochondrial protein complex 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 5.44e-06 143 7 4 0.571 0.028 GO:0044455 CC 1 mitochondrial membrane part 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 6.77e-06 399 7 5 0.714 0.013 GO:0031966 CC 1 mitochondrial membrane 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 8.76e-06 39 7 3 0.429 0.077 GO:0032592 CC 1 integral component of mitochondrial membrane 1 Q9NX63,Q16891,Q9BRQ6 344 1.02e-05 41 7 3 0.429 0.073 GO:0098573 CC 1 intrinsic component of mitochondrial membrane 1 Q9NX63,Q16891,Q9BRQ6 344 1.03e-05 434 7 5 0.714 0.012 GO:0005740 CC 1 mitochondrial envelope 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 8.45e-05 665 7 5 0.714 0.008 GO:0031967 CC 1 organelle envelope 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 8.64e-05 668 7 5 0.714 0.007 GO:0031975 CC 1 envelope 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 9.03e-05 674 7 5 0.714 0.007 GO:0044429 CC 1 mitochondrial part 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 9.69e-05 86 7 3 0.429 0.035 GO:0031301 CC 1 integral component of organelle membrane 1 Q9NX63,Q16891,Q9BRQ6 344 1.27e-04 94 7 3 0.429 0.032 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 Q9NX63,Q16891,Q9BRQ6 344 1.27e-04 94 7 3 0.429 0.032 GO:0031300 CC 1 intrinsic component of organelle membrane 1 Q9NX63,Q16891,Q9BRQ6 344 4.88e-04 444 7 4 0.571 0.009 GO:0098796 CC 1 membrane protein complex 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 7.13e-04 1029 7 5 0.714 0.005 GO:0005739 CC 1 mitochondrion 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 8.40e-04 510 7 4 0.571 0.008 GO:0007005 BP 1 mitochondrion organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 1.91e-03 630 7 4 0.571 0.006 GO:0044802 BP 1 single-organism membrane organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 3.29e-03 1414 7 5 0.714 0.004 GO:0031090 CC 1 organelle membrane 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6 344 3.72e-03 749 7 4 0.571 0.005 GO:0061024 BP 1 membrane organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 4.06e-03 302 7 3 0.429 0.010 GO:0005743 CC 1 mitochondrial inner membrane 1 Q9NX63,Q16891,Q9BRQ6 344 4.29e-03 1 7 1 0.143 1.000 GO:0001401 CC 1 mitochondrial sorting and assembly machinery complex 1 Q9Y512 344 5.04e-03 325 7 3 0.429 0.009 GO:0019866 CC 1 organelle inner membrane 1 Q9NX63,Q16891,Q9BRQ6 344 8.71e-03 90 7 2 0.286 0.022 GO:0005741 CC 1 mitochondrial outer membrane 1 Q9Y512,O75431 344 9.90e-03 96 7 2 0.286 0.021 GO:0031968 CC 1 organelle outer membrane 1 Q9Y512,O75431 344 1.01e-02 97 7 2 0.286 0.021 GO:0019867 CC 1 outer membrane 1 Q9Y512,O75431 344 2.01e-02 1168 7 4 0.571 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 2.14e-02 5 7 1 0.143 0.200 GO:0045040 BP 1 protein import into mitochondrial outer membrane 1 Q9Y512 344 3.00e-02 7 7 1 0.143 0.143 GO:0007008 BP 1 outer mitochondrial membrane organization 1 Q9Y512 344 3.00e-02 7 7 1 0.143 0.143 GO:0050700 MF 1 CARD domain binding 1 Q96LW7 344 3.85e-02 9 7 1 0.143 0.111 GO:0090151 BP 1 establishment of protein localization to mitochondrial membrane 1 Q9Y512 344 3.85e-02 9 7 1 0.143 0.111 GO:0098799 CC 1 outer mitochondrial membrane protein complex 1 Q9Y512 344 3.86e-02 1392 7 4 0.571 0.003 GO:0016021 CC 1 integral component of membrane 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 4.21e-02 1722 7 6 0.857 0.003 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 Q9Y512,Q9NX63,O75431,Q16891,Q9BRQ6,Q5HYI7 344 4.37e-02 1440 7 4 0.571 0.003 GO:0031224 CC 1 intrinsic component of membrane 1 Q9Y512,Q9NX63,Q16891,Q9BRQ6 344 4.77e-02 478 7 3 0.429 0.006 MI:mmu-miR-465a-5p mi 1 MI:mmu-miR-465a-5p 1 O75431,Q16891,Q96LW7 344 5.00e-02 56 7 3 0.429 0.054 REAC:1268020 rea 1 Mitochondrial protein import 1 Q9Y512,Q9NX63,O75431 344 5.00e-02 486 7 3 0.429 0.006 MI:mmu-miR-465c-5p mi 1 MI:mmu-miR-465c-5p 1 O75431,Q16891,Q96LW7 344 5.00e-02 476 7 4 0.571 0.008 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 Q9Y512,Q9NX63,O75431,Q16891 344 5.00e-02 219 7 2 0.286 0.009 GO:0006839 BP 1 mitochondrial transport 1 Q9Y512,O75431 345 9.97e-08 24 4 3 0.750 0.125 GO:0005689 CC 1 U12-type spliceosomal complex 1 Q9UDW3,Q15696,Q16560 345 2.25e-06 51 4 3 0.750 0.059 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q9UDW3,Q15696,Q16560 345 7.20e-06 23 4 3 0.750 0.130 CORUM:430 cor 1 18S U11/U12 snRNP 1 Q9UDW3,Q15696,Q16560 345 2.27e-05 599 4 4 1.000 0.007 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.29e-05 600 4 4 1.000 0.007 GO:1990904 CC 1 ribonucleoprotein complex 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.53e-05 147 4 3 0.750 0.020 GO:0005681 CC 1 spliceosomal complex 1 Q9UDW3,Q15696,Q16560 345 1.02e-04 180 4 3 0.750 0.017 REAC:72172 rea 1 mRNA Splicing 1 Q9UDW3,Q15696,Q16560 345 1.49e-04 265 4 3 0.750 0.011 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 Q9UDW3,Q15696,Q16560 345 1.49e-04 265 4 3 0.750 0.011 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 Q9UDW3,Q15696,Q16560 345 1.55e-04 269 4 3 0.750 0.011 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 Q9UDW3,Q15696,Q16560 345 2.07e-04 228 4 3 0.750 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q9UDW3,Q15696,Q16560 345 2.76e-04 326 4 3 0.750 0.009 GO:0008380 BP 1 RNA splicing 1 Q9UDW3,Q15696,Q16560 345 3.19e-04 342 4 3 0.750 0.009 GO:0006397 BP 1 mRNA processing 1 Q9UDW3,Q15696,Q16560 345 1.12e-03 522 4 3 0.750 0.006 GO:0016071 BP 1 mRNA metabolic process 1 Q9UDW3,Q15696,Q16560 345 3.13e-03 3011 4 4 1.000 0.001 TF:M02102_0 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.25e-03 1219 4 3 0.750 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q96F63,Q15696,Q16560 345 3.31e-03 752 4 3 0.750 0.004 GO:0006396 BP 1 RNA processing 1 Q9UDW3,Q15696,Q16560 345 4.37e-03 4 4 1 0.250 0.250 GO:0089701 CC 1 U2AF 1 Q15696 345 4.71e-03 15 4 1 0.250 0.067 TF:M06743_0 tf 1 Factor: ZNF287; motif: NTGTTAAGACGM; match class: 0 1 Q15696 345 5.46e-03 5 4 1 0.250 0.200 GO:0030628 MF 1 pre-mRNA 3'-splice site binding 1 Q15696 345 6.36e-03 360 4 2 0.500 0.006 HPA:021010_03 hpa 1 liver; bile duct cells[Uncertain,High] 1 Q9UDW3,Q16560 345 7.35e-03 402 4 2 0.500 0.005 MI:hsa-miR-187 mi 1 MI:hsa-miR-187 1 Q9UDW3,Q15696 345 7.65e-03 7 4 1 0.250 0.143 GO:0000243 CC 1 commitment complex 1 Q16560 345 8.54e-03 434 4 2 0.500 0.005 MI:mmu-miR-463 mi 1 MI:mmu-miR-463 1 Q9UDW3,Q15696 345 9.99e-03 1793 4 3 0.750 0.002 TF:M04122_1 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 1 1 Q9UDW3,Q96F63,Q16560 345 9.99e-03 1793 4 3 0.750 0.002 TF:M04117_1 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 1 1 Q9UDW3,Q96F63,Q16560 345 9.99e-03 1793 4 3 0.750 0.002 TF:M04137_1 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 1 1 Q9UDW3,Q96F63,Q16560 345 9.99e-03 1793 4 3 0.750 0.002 TF:M04126_1 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 1 1 Q9UDW3,Q96F63,Q16560 345 9.99e-03 1793 4 3 0.750 0.002 TF:M04135_1 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 1 1 Q9UDW3,Q96F63,Q16560 345 1.03e-02 33 4 1 0.250 0.030 TF:M06597_1 tf 1 Factor: ZNF775; motif: KGTTTAAGSG; match class: 1 1 Q96F63 345 1.10e-02 35 4 1 0.250 0.029 TF:M03950_0 tf 1 Factor: CDP; motif: ATCGATNNNNNATCRAT; match class: 0 1 Q16560 345 1.10e-02 35 4 1 0.250 0.029 TF:M05957_0 tf 1 Factor: ZNF306; motif: KGGGTAAGMCGM; match class: 0 1 Q16560 345 1.16e-02 37 4 1 0.250 0.027 TF:M06762_0 tf 1 Factor: ZNF222; motif: NGGTCRAAACGA; match class: 0 1 Q96F63 345 1.19e-02 4208 4 4 1.000 0.001 TF:M00761_1 tf 1 Factor: p53; motif: RGRCAWGNCY; match class: 1 1 Q9UDW3,Q96F63,Q15696,Q16560 345 1.23e-02 595 4 2 0.500 0.003 TF:M00065_0 tf 1 Factor: Tal-1beta:E47; motif: NNNAACAGATGKTNNN; match class: 0 1 Q9UDW3,Q15696 345 1.29e-02 537 4 2 0.500 0.004 MI:hsa-miR-30c mi 1 MI:hsa-miR-30c 1 Q9UDW3,Q15696 345 1.35e-02 4337 4 4 1.000 0.001 TF:M07278_0 tf 1 Factor: Dlx3; motif: NTAATTNVN; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 1.35e-02 625 4 2 0.500 0.003 TF:M03543_1 tf 1 Factor: COUP-TF2; motif: GNCARAGGTCANRRN; match class: 1 1 Q9UDW3,Q16560 345 1.36e-02 552 4 2 0.500 0.004 MI:hsa-miR-30b mi 1 MI:hsa-miR-30b 1 Q9UDW3,Q15696 345 1.42e-02 564 4 2 0.500 0.004 MI:hsa-miR-518e mi 1 MI:hsa-miR-518e 1 Q96F63,Q15696 345 1.47e-02 47 4 1 0.250 0.021 TF:M06259_0 tf 1 Factor: ZNF91; motif: NATGGCGGCCGC; match class: 0 1 Q9UDW3 345 1.50e-02 48 4 1 0.250 0.021 TF:M06103_0 tf 1 Factor: ZNF325; motif: NKGGCAAGAARM; match class: 0 1 Q9UDW3 345 1.59e-02 51 4 1 0.250 0.020 TF:M06454_0 tf 1 Factor: ZNF786; motif: KGGWTYAGGGGA; match class: 0 1 Q15696 345 1.70e-02 4594 4 4 1.000 0.001 TF:M02014_1 tf 1 Factor: HNF-3beta; motif: NTRTTTRYT; match class: 1 1 Q9UDW3,Q96F63,Q15696,Q16560 345 1.76e-02 3931 4 4 1.000 0.001 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 Q9UDW3,Q96F63,Q15696,Q16560 345 1.79e-02 3168 4 4 1.000 0.001 GO:0044428 CC 1 nuclear part 1 Q9UDW3,Q96F63,Q15696,Q16560 345 1.96e-02 18 4 1 0.250 0.056 GO:0036002 MF 1 pre-mRNA binding 1 Q15696 345 2.00e-02 64 4 1 0.250 0.016 TF:M05826_0 tf 1 Factor: ZNF66; motif: GTSTTCAACTWA; match class: 0 1 Q15696 345 2.07e-02 19 4 1 0.250 0.053 GO:0005686 CC 1 U2 snRNP 1 Q96F63 345 2.13e-02 791 4 2 0.500 0.003 TF:M01259_0 tf 1 Factor: CTCF; motif: NNNNNNCCASNAGRKGGCRS; match class: 0 1 Q96F63,Q15696 345 2.19e-02 4895 4 4 1.000 0.001 TF:M07435_0 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.28e-02 4949 4 4 1.000 0.001 TF:M00289_0 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.42e-02 3415 4 4 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.61e-02 84 4 1 0.250 0.012 TF:M05865_0 tf 1 Factor: ZNF709; motif: NGYTCCAACACC; match class: 0 1 Q96F63 345 2.71e-02 87 4 1 0.250 0.011 TF:M06727_1 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 1 1 Q9UDW3 345 2.71e-02 5164 4 4 1.000 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.72e-02 25 4 1 0.250 0.040 GO:0071011 CC 1 precatalytic spliceosome 1 Q16560 345 2.77e-02 89 4 1 0.250 0.011 TF:M00778_0 tf 1 Factor: AhR; motif: NTNGCGTGNNN; match class: 0 1 Q96F63 345 2.77e-02 908 4 2 0.500 0.002 TF:M03844_1 tf 1 Factor: SAP-1a; motif: CWTCCKGT; match class: 1 1 Q9UDW3,Q15696 345 2.77e-02 908 4 2 0.500 0.002 TF:M07282_1 tf 1 Factor: ER71; motif: CWTCCTGT; match class: 1 1 Q9UDW3,Q15696 345 2.82e-02 916 4 2 0.500 0.002 TF:M03889_1 tf 1 Factor: TBX2; motif: AGGTGTGARM; match class: 1 1 Q9UDW3,Q16560 345 2.84e-02 4433 4 4 1.000 0.001 HPA:034010_02 hpa 1 skeletal muscle; myocytes[Uncertain,Medium] 1 Q9UDW3,Q96F63,Q15696,Q16560 345 2.89e-02 93 4 1 0.250 0.011 TF:M00260_1 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 1 1 Q15696 345 3.26e-02 2716 4 3 0.750 0.001 TF:M03562_0 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 0 1 Q96F63,Q15696,Q16560 345 3.26e-02 840 4 2 0.500 0.002 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 Q9UDW3,Q16560 345 3.35e-02 2743 4 3 0.750 0.001 TF:M04084_0 tf 1 Factor: POU3F4; motif: TGCATAAWTTA; match class: 0 1 Q9UDW3,Q96F63,Q15696 345 3.38e-02 31 4 1 0.250 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 Q16560 345 3.38e-02 31 4 1 0.250 0.032 GO:0017069 MF 1 snRNA binding 1 Q16560 345 3.41e-02 5471 4 4 1.000 0.001 TF:M00252_0 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.41e-02 110 4 1 0.250 0.009 TF:M01142_1 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 1 1 Q9UDW3 345 3.51e-02 2787 4 3 0.750 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q96F63,Q15696,Q16560 345 3.54e-02 114 4 1 0.250 0.009 TF:M01774_1 tf 1 Factor: TBR2; motif: AGGTGTGAA; match class: 1 1 Q96F63 345 3.62e-02 1046 4 2 0.500 0.002 TF:M00262_0 tf 1 Factor: Staf; motif: NTTWCCCANMATGCAYYRCGNY; match class: 0 1 Q9UDW3,Q16560 345 3.77e-02 906 4 2 0.500 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q96F63,Q16560 345 3.77e-02 5611 4 4 1.000 0.001 TF:M07286_1 tf 1 Factor: FOXO1A; motif: TTGTTTWN; match class: 1 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.81e-02 123 4 1 0.250 0.008 TF:M05680_0 tf 1 Factor: ZNF80; motif: NTGGGCTGGGGW; match class: 0 1 Q9UDW3 345 3.82e-02 913 4 2 0.500 0.002 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q96F63,Q16560 345 3.87e-02 919 4 2 0.500 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q96F63,Q16560 345 3.93e-02 927 4 2 0.500 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 Q96F63,Q16560 345 3.94e-02 5672 4 4 1.000 0.001 TF:M04122_0 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.94e-02 5672 4 4 1.000 0.001 TF:M04137_0 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.94e-02 5672 4 4 1.000 0.001 TF:M04135_0 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.94e-02 5672 4 4 1.000 0.001 TF:M04117_0 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 3.94e-02 5672 4 4 1.000 0.001 TF:M04126_0 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 0 1 Q9UDW3,Q96F63,Q15696,Q16560 345 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q96F63,Q16560 345 4.15e-02 134 4 1 0.250 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q16560 345 4.17e-02 2966 4 3 0.750 0.001 TF:M01869_0 tf 1 Factor: C/EBPgamma; motif: NRTKRSRMAAKN; match class: 0 1 Q96F63,Q15696,Q16560 345 4.19e-02 2970 4 3 0.750 0.001 TF:M03558_0 tf 1 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN; match class: 0 1 Q9UDW3,Q96F63,Q16560 345 4.23e-02 2527 4 3 0.750 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 Q9UDW3,Q96F63,Q16560 345 4.59e-02 1187 4 2 0.500 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 Q96F63,Q15696 345 4.66e-02 151 4 1 0.250 0.007 TF:M04619_1 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 1 Q96F63 345 4.68e-02 1200 4 2 0.500 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q9UDW3,Q15696 345 4.72e-02 3100 4 3 0.750 0.001 TF:M00377_1 tf 1 Factor: Pax-4; motif: NAAWAATTANS; match class: 1 1 Q9UDW3,Q96F63,Q15696 345 4.77e-02 131 4 1 0.250 0.008 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 Q16560 345 4.90e-02 159 4 1 0.250 0.006 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 Q96F63 345 4.93e-02 160 4 1 0.250 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q15696 345 4.94e-02 6001 4 4 1.000 0.001 TF:M03582_1 tf 1 Factor: TWIST; motif: CACCTGG; match class: 1 1 Q9UDW3,Q96F63,Q15696,Q16560 345 4.98e-02 3160 4 3 0.750 0.001 TF:M00130_1 tf 1 Factor: FOXD3; motif: NAWTGTTTRTTT; match class: 1 1 Q96F63,Q15696,Q16560 345 5.00e-02 46 4 1 0.250 0.022 GO:0000245 BP 1 spliceosomal complex assembly 1 Q15696 345 5.00e-02 14 4 1 0.250 0.071 CORUM:1068 cor 1 12S U11 snRNP 1 Q16560 345 5.00e-02 1485 4 3 0.750 0.002 REAC:74160 rea 1 Gene Expression 1 Q9UDW3,Q15696,Q16560 346 3.91e-05 275 3 3 1.000 0.011 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 7.48e-05 341 3 3 1.000 0.009 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.02e-05 349 3 3 1.000 0.009 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.58e-05 357 3 3 1.000 0.008 HPA:034010_13 hpa 1 skeletal muscle; myocytes[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.09e-04 11 3 2 0.667 0.182 CORUM:3082 cor 1 DGCR8 multiprotein complex 1 Q12906,Q08211 346 1.28e-04 408 3 3 1.000 0.007 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.36e-04 416 3 3 1.000 0.007 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.77e-04 454 3 3 1.000 0.007 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.14e-04 484 3 3 1.000 0.006 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.21e-04 489 3 3 1.000 0.006 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.44e-04 505 3 3 1.000 0.006 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.93e-04 537 3 3 1.000 0.006 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 3.24e-04 555 3 3 1.000 0.005 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.26e-04 608 3 3 1.000 0.005 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.43e-04 616 3 3 1.000 0.005 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 4.83e-04 634 3 3 1.000 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 5.27e-04 653 3 3 1.000 0.005 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 5.70e-04 318 3 3 1.000 0.009 GO:0010608 BP 1 posttranscriptional regulation of gene expression 1 Q07666,Q12906,Q08211 346 6.01e-04 682 3 3 1.000 0.004 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 6.87e-04 713 3 3 1.000 0.004 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 7.46e-04 733 3 3 1.000 0.004 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.09e-04 753 3 3 1.000 0.004 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.16e-04 755 3 3 1.000 0.004 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 8.35e-04 761 3 3 1.000 0.004 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.82e-04 775 3 3 1.000 0.004 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 8.88e-04 121 3 2 0.667 0.017 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 Q07666,Q12906 346 9.03e-04 781 3 3 1.000 0.004 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 9.85e-04 804 3 3 1.000 0.004 HPA:019010_03 hpa 1 kidney; cells in glomeruli[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.11e-03 836 3 3 1.000 0.004 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.12e-03 838 3 3 1.000 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.24e-03 867 3 3 1.000 0.003 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.27e-03 874 3 3 1.000 0.003 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.28e-03 877 3 3 1.000 0.003 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.31e-03 147 3 2 0.667 0.014 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q07666,Q12906 346 1.39e-03 902 3 3 1.000 0.003 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.42e-03 909 3 3 1.000 0.003 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.44e-03 913 3 3 1.000 0.003 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.47e-03 919 3 3 1.000 0.003 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.48e-03 921 3 3 1.000 0.003 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.51e-03 927 3 3 1.000 0.003 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.53e-03 930 3 3 1.000 0.003 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.57e-03 938 3 3 1.000 0.003 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.67e-03 958 3 3 1.000 0.003 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.70e-03 965 3 3 1.000 0.003 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.77e-03 977 3 3 1.000 0.003 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.86e-03 994 3 3 1.000 0.003 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.87e-03 995 3 3 1.000 0.003 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 1.91e-03 1002 3 3 1.000 0.003 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.04e-03 1025 3 3 1.000 0.003 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.06e-03 1028 3 3 1.000 0.003 HPA:034010_03 hpa 1 skeletal muscle; myocytes[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.23e-03 1055 3 3 1.000 0.003 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.38e-03 1078 3 3 1.000 0.003 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.38e-03 1078 3 3 1.000 0.003 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.42e-03 200 3 2 0.667 0.010 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 Q07666,Q12906 346 2.45e-03 201 3 2 0.667 0.010 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q07666,Q12906 346 2.46e-03 1091 3 3 1.000 0.003 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.53e-03 1100 3 3 1.000 0.003 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.54e-03 205 3 2 0.667 0.010 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 Q07666,Q12906 346 2.57e-03 1107 3 3 1.000 0.003 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.66e-03 4 3 1 0.333 0.250 REAC:8849468 rea 1 PTK6 Regulates Proteins Involved in RNA Processing 1 Q07666 346 2.67e-03 1121 3 3 1.000 0.003 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.73e-03 1129 3 3 1.000 0.003 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.76e-03 1133 3 3 1.000 0.003 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q07666,Q12906,Q08211 346 2.77e-03 1135 3 3 1.000 0.003 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.85e-03 217 3 2 0.667 0.009 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 Q07666,Q12906 346 2.90e-03 1152 3 3 1.000 0.003 HPA:020020_03 hpa 1 lateral ventricle; neuronal cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.95e-03 221 3 2 0.667 0.009 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 Q07666,Q12906 346 3.08e-03 1175 3 3 1.000 0.003 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 3.11e-03 1179 3 3 1.000 0.003 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 3.28e-03 233 3 2 0.667 0.009 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q07666,Q12906 346 3.46e-03 1221 3 3 1.000 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q07666,Q12906,Q08211 346 3.53e-03 1230 3 3 1.000 0.002 HPA:041010_12 hpa 1 spleen; cells in red pulp[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 3.63e-03 1241 3 3 1.000 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 3.64e-03 1242 3 3 1.000 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 3.68e-03 1247 3 3 1.000 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 3.93e-03 1274 3 3 1.000 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.08e-03 1291 3 3 1.000 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 4.24e-03 1307 3 3 1.000 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.25e-03 1308 3 3 1.000 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.46e-03 1329 3 3 1.000 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 4.59e-03 2 3 1 0.333 0.500 CORUM:3080 cor 1 ILF3-XPO5 complex 1 Q12906 346 4.59e-03 2 3 1 0.333 0.500 CORUM:644 cor 1 ASPP1-SAM68 complex 1 Q07666 346 4.59e-03 2 3 1 0.333 0.500 CORUM:3079 cor 1 DGCR8-ILF3 complex 1 Q12906 346 4.59e-03 2 3 1 0.333 0.500 CORUM:2578 cor 1 Sam68-p120GAP complex 1 Q07666 346 4.78e-03 1360 3 3 1.000 0.002 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 5.17e-03 1396 3 3 1.000 0.002 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 5.17e-03 1396 3 3 1.000 0.002 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 5.30e-03 1408 3 3 1.000 0.002 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 5.35e-03 298 3 2 0.667 0.007 HPA:009010_13 hpa 1 colon; endothelial cells[Supportive,High] 1 Q12906,Q08211 346 5.43e-03 1419 3 3 1.000 0.002 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 5.82e-03 1453 3 3 1.000 0.002 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 5.90e-03 1459 3 3 1.000 0.002 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 6.05e-03 317 3 2 0.667 0.006 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 Q07666,Q12906 346 6.16e-03 1480 3 3 1.000 0.002 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 6.31e-03 1492 3 3 1.000 0.002 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q07666,Q12906,Q08211 346 6.40e-03 1499 3 3 1.000 0.002 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 6.51e-03 1508 3 3 1.000 0.002 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 6.51e-03 329 3 2 0.667 0.006 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 Q07666,Q12906 346 6.58e-03 1513 3 3 1.000 0.002 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 6.64e-03 10 3 1 0.333 0.100 REAC:3134963 rea 1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1 Q08211 346 6.67e-03 333 3 2 0.667 0.006 HPA:020010_13 hpa 1 lateral ventricle; glial cells[Supportive,High] 1 Q12906,Q08211 346 6.68e-03 1521 3 3 1.000 0.002 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 6.87e-03 1535 3 3 1.000 0.002 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 6.87e-03 338 3 2 0.667 0.006 HPA:041010_13 hpa 1 spleen; cells in red pulp[Supportive,High] 1 Q07666,Q12906 346 6.87e-03 3 3 1 0.333 0.333 CORUM:2577 cor 1 Sam68-p85 P13K-IRS-1-IR signaling complex 1 Q07666 346 6.87e-03 3 3 1 0.333 0.333 CORUM:3129 cor 1 STAT6-p100-RHA complex 1 Q08211 346 6.87e-03 3 3 1 0.333 0.333 CORUM:3618 cor 1 GammaH2AFX-NDHII-Ku70-DNA complex 1 Q08211 346 7.03e-03 342 3 2 0.667 0.006 HPA:039020_03 hpa 1 soft tissue 1; chondrocytes[Uncertain,High] 1 Q07666,Q12906 346 7.16e-03 345 3 2 0.667 0.006 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 Q07666,Q12906 346 7.20e-03 1559 3 3 1.000 0.002 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.41e-03 351 3 2 0.667 0.006 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 Q07666,Q08211 346 7.41e-03 1574 3 3 1.000 0.002 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.43e-03 1576 3 3 1.000 0.002 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.46e-03 1578 3 3 1.000 0.002 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 7.53e-03 1583 3 3 1.000 0.002 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 Q07666,Q12906,Q08211 346 7.62e-03 1589 3 3 1.000 0.002 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.62e-03 1589 3 3 1.000 0.002 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.78e-03 1600 3 3 1.000 0.002 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 7.92e-03 363 3 2 0.667 0.006 HPA:026020_03 hpa 1 ovary; ovarian stroma cells[Uncertain,High] 1 Q07666,Q12906 346 8.06e-03 1619 3 3 1.000 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 8.09e-03 1621 3 3 1.000 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q07666,Q12906,Q08211 346 8.10e-03 1622 3 3 1.000 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 8.10e-03 1622 3 3 1.000 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q07666,Q12906,Q08211 346 8.12e-03 1623 3 3 1.000 0.002 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 8.13e-03 368 3 2 0.667 0.005 HPA:022020_13 hpa 1 lung; pneumocytes[Supportive,High] 1 Q07666,Q12906 346 8.18e-03 369 3 2 0.667 0.005 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 Q07666,Q08211 346 8.27e-03 1633 3 3 1.000 0.002 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 8.30e-03 1635 3 3 1.000 0.002 HPA:039020_02 hpa 1 soft tissue 1; chondrocytes[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 8.67e-03 1659 3 3 1.000 0.002 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 8.85e-03 1670 3 3 1.000 0.002 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 9.17e-03 391 3 2 0.667 0.005 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 Q07666,Q12906 346 9.26e-03 393 3 2 0.667 0.005 HPA:041020_13 hpa 1 spleen; cells in white pulp[Supportive,High] 1 Q07666,Q12906 346 9.31e-03 394 3 2 0.667 0.005 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 Q07666,Q12906 346 9.40e-03 1704 3 3 1.000 0.002 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 9.45e-03 1707 3 3 1.000 0.002 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 9.73e-03 403 3 2 0.667 0.005 HPA:007010_03 hpa 1 cerebral cortex; endothelial cells[Uncertain,High] 1 Q07666,Q12906 346 9.78e-03 404 3 2 0.667 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q07666,Q12906 346 1.02e-02 103 3 2 0.667 0.019 CORUM:3055 cor 1 Nop56p-associated pre-rRNA complex 1 Q12906,Q08211 346 1.03e-02 1756 3 3 1.000 0.002 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.04e-02 1765 3 3 1.000 0.002 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.05e-02 1769 3 3 1.000 0.002 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.07e-02 1780 3 3 1.000 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.07e-02 1782 3 3 1.000 0.002 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.08e-02 1787 3 3 1.000 0.002 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.09e-02 1788 3 3 1.000 0.002 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.10e-02 1797 3 3 1.000 0.002 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.11e-02 1803 3 3 1.000 0.002 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.12e-02 1804 3 3 1.000 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.13e-02 1813 3 3 1.000 0.002 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.14e-02 1818 3 3 1.000 0.002 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.15e-02 1820 3 3 1.000 0.002 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.15e-02 1825 3 3 1.000 0.002 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.16e-02 1830 3 3 1.000 0.002 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 1.19e-02 18 3 1 0.333 0.056 REAC:1810476 rea 1 RIP-mediated NFkB activation via ZBP1 1 Q08211 346 1.23e-02 1863 3 3 1.000 0.002 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.26e-02 1880 3 3 1.000 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.27e-02 1883 3 3 1.000 0.002 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.31e-02 1904 3 3 1.000 0.002 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.32e-02 1909 3 3 1.000 0.002 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.35e-02 476 3 2 0.667 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 Q07666,Q12906 346 1.35e-02 1924 3 3 1.000 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.37e-02 1932 3 3 1.000 0.002 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.37e-02 1932 3 3 1.000 0.002 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.37e-02 1933 3 3 1.000 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.37e-02 6 3 1 0.333 0.167 CORUM:3102 cor 1 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex 1 Q08211 346 1.39e-02 1941 3 3 1.000 0.002 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.39e-02 21 3 1 0.333 0.048 REAC:1606322 rea 1 ZBP1(DAI) mediated induction of type I IFNs 1 Q08211 346 1.41e-02 1950 3 3 1.000 0.002 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.41e-02 486 3 2 0.667 0.004 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q07666,Q12906 346 1.43e-02 2 3 1 0.333 0.500 GO:0032241 BP 1 positive regulation of nucleobase-containing compound transport 1 Q07666 346 1.43e-02 2 3 1 0.333 0.500 GO:0046833 BP 1 positive regulation of RNA export from nucleus 1 Q07666 346 1.43e-02 2 3 1 0.333 0.500 GO:0097165 CC 1 nuclear stress granule 1 Q08211 346 1.46e-02 22 3 1 0.333 0.045 REAC:933542 rea 1 TRAF6 mediated NF-kB activation 1 Q08211 346 1.46e-02 495 3 2 0.667 0.004 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 Q07666,Q12906 346 1.46e-02 1974 3 3 1.000 0.002 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.48e-02 498 3 2 0.667 0.004 HPA:022010_13 hpa 1 lung; macrophages[Supportive,High] 1 Q07666,Q12906 346 1.48e-02 1984 3 3 1.000 0.002 HPA:007030_03 hpa 1 cerebral cortex; neuronal cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.49e-02 1986 3 3 1.000 0.002 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.49e-02 1989 3 3 1.000 0.002 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.50e-02 1990 3 3 1.000 0.002 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.51e-02 1996 3 3 1.000 0.002 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.52e-02 1998 3 3 1.000 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.58e-02 2024 3 3 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.58e-02 2026 3 3 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.59e-02 2029 3 3 1.000 0.001 HPA:045010_03 hpa 1 thyroid gland; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.59e-02 24 3 1 0.333 0.042 REAC:445989 rea 1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 1 Q08211 346 1.60e-02 7 3 1 0.333 0.143 CORUM:924 cor 1 Toposome 1 Q08211 346 1.61e-02 2039 3 3 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.62e-02 2043 3 3 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.64e-02 2051 3 3 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 1.64e-02 2051 3 3 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.65e-02 2055 3 3 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.66e-02 2060 3 3 1.000 0.001 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.68e-02 531 3 2 0.667 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q07666,Q12906 346 1.69e-02 2071 3 3 1.000 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.69e-02 2072 3 3 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.69e-02 2072 3 3 1.000 0.001 HPA:039020_10 hpa 1 soft tissue 1; chondrocytes[Supportive,Not detected] 1 Q07666,Q12906,Q08211 346 1.71e-02 2079 3 3 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.72e-02 2086 3 3 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.73e-02 540 3 2 0.667 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q12906,Q08211 346 1.74e-02 2092 3 3 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.74e-02 541 3 2 0.667 0.004 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 Q07666,Q12906 346 1.76e-02 2102 3 3 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.78e-02 2110 3 3 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.79e-02 549 3 2 0.667 0.004 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 Q07666,Q12906 346 1.83e-02 8 3 1 0.333 0.125 CORUM:5183 cor 1 DNA-PK-Ku-eIF2-NF90-NF45 complex 1 Q12906 346 1.84e-02 2130 3 3 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.86e-02 2139 3 3 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.86e-02 2139 3 3 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.89e-02 564 3 2 0.667 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q07666,Q08211 346 1.89e-02 564 3 2 0.667 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q07666,Q12906 346 1.89e-02 2151 3 3 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.90e-02 2153 3 3 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.90e-02 2154 3 3 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.91e-02 567 3 2 0.667 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 Q07666,Q12906 346 1.91e-02 2159 3 3 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.93e-02 2165 3 3 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 1.94e-02 2168 3 3 1.000 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.95e-02 2173 3 3 1.000 0.001 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.96e-02 2176 3 3 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 1.96e-02 2177 3 3 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 1.98e-02 2183 3 3 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 1.99e-02 2188 3 3 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.00e-02 580 3 2 0.667 0.003 HPA:046010_13 hpa 1 tonsil; germinal center cells[Supportive,High] 1 Q07666,Q12906 346 2.00e-02 2191 3 3 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.02e-02 2197 3 3 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.02e-02 2200 3 3 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 Q07666,Q12906,Q08211 346 2.03e-02 2202 3 3 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.05e-02 2209 3 3 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.06e-02 589 3 2 0.667 0.003 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 Q07666,Q12906 346 2.06e-02 2215 3 3 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.10e-02 2227 3 3 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.10e-02 2227 3 3 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q07666,Q12906,Q08211 346 2.10e-02 596 3 2 0.667 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q07666,Q12906 346 2.22e-02 2270 3 3 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.23e-02 2271 3 3 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.23e-02 2274 3 3 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.23e-02 2274 3 3 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.23e-02 2274 3 3 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.24e-02 2276 3 3 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.25e-02 2279 3 3 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.26e-02 2281 3 3 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.27e-02 2286 3 3 1.000 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 2.27e-02 2286 3 3 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.28e-02 2290 3 3 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.28e-02 10 3 1 0.333 0.100 CORUM:1749 cor 1 SMN-PolII-RHA complex 1 Q08211 346 2.30e-02 624 3 2 0.667 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q07666,Q12906 346 2.31e-02 625 3 2 0.667 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q07666,Q12906 346 2.34e-02 2308 3 3 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.34e-02 2310 3 3 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.35e-02 631 3 2 0.667 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q12906,Q08211 346 2.37e-02 2318 3 3 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.40e-02 2328 3 3 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.41e-02 639 3 2 0.667 0.003 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 Q07666,Q08211 346 2.44e-02 2342 3 3 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.44e-02 2342 3 3 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.49e-02 650 3 2 0.667 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q07666,Q12906 346 2.50e-02 1118 3 3 1.000 0.003 GO:0044822 MF 1 poly(A) RNA binding 1 Q07666,Q12906,Q08211 346 2.51e-02 652 3 2 0.667 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q12906,Q08211 346 2.52e-02 2366 3 3 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.52e-02 653 3 2 0.667 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 Q12906,Q08211 346 2.58e-02 2385 3 3 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.58e-02 661 3 2 0.667 0.003 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 Q07666,Q12906 346 2.59e-02 206 3 2 0.667 0.010 GO:0006417 BP 1 regulation of translation 1 Q07666,Q12906 346 2.61e-02 2395 3 3 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.62e-02 2397 3 3 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.68e-02 674 3 2 0.667 0.003 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 Q07666,Q12906 346 2.68e-02 2417 3 3 1.000 0.001 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.71e-02 2425 3 3 1.000 0.001 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.72e-02 2429 3 3 1.000 0.001 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.74e-02 2435 3 3 1.000 0.001 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.81e-02 2454 3 3 1.000 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 2.81e-02 2454 3 3 1.000 0.001 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.82e-02 2458 3 3 1.000 0.001 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.86e-02 2469 3 3 1.000 0.001 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.86e-02 2470 3 3 1.000 0.001 HPA:026010_02 hpa 1 ovary; follicle cells[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 2.87e-02 2472 3 3 1.000 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.89e-02 2477 3 3 1.000 0.001 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.95e-02 2495 3 3 1.000 0.001 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.96e-02 2496 3 3 1.000 0.001 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 Q07666,Q12906,Q08211 346 2.99e-02 2505 3 3 1.000 0.001 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 Q07666,Q12906,Q08211 346 3.13e-02 730 3 2 0.667 0.003 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q12906,Q08211 346 3.14e-02 2547 3 3 1.000 0.001 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q07666,Q12906,Q08211 346 3.19e-02 229 3 2 0.667 0.009 GO:0034248 BP 1 regulation of cellular amide metabolic process 1 Q07666,Q12906 346 3.24e-02 2574 3 3 1.000 0.001 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 Q07666,Q12906,Q08211 346 3.27e-02 2582 3 3 1.000 0.001 HPA:039020_01 hpa 1 soft tissue 1; chondrocytes[Uncertain,Low] 1 Q07666,Q12906,Q08211 346 3.28e-02 2585 3 3 1.000 0.001 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 3.52e-02 2647 3 3 1.000 0.001 HPA:001010_03 hpa 1 adrenal gland; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 3.57e-02 5 3 1 0.333 0.200 GO:0070934 BP 1 CRD-mediated mRNA stabilization 1 Q08211 346 3.62e-02 786 3 2 0.667 0.003 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 Q07666,Q12906 346 3.69e-02 56 3 1 0.333 0.018 REAC:8848021 rea 1 Signaling by PTK6 1 Q07666 346 3.73e-02 798 3 2 0.667 0.003 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 Q07666,Q12906 346 3.76e-02 802 3 2 0.667 0.002 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 Q07666,Q12906 346 3.77e-02 803 3 2 0.667 0.002 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 Q07666,Q12906 346 3.96e-02 60 3 1 0.333 0.017 REAC:1834949 rea 1 Cytosolic sensors of pathogen-associated DNA 1 Q08211 346 4.04e-02 832 3 2 0.667 0.002 HPA:009030_03 hpa 1 colon; peripheral nerve/ganglion[Uncertain,High] 1 Q07666,Q08211 346 4.09e-02 62 3 1 0.333 0.016 REAC:168928 rea 1 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 1 Q08211 346 4.12e-02 840 3 2 0.667 0.002 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 Q07666,Q12906 346 4.13e-02 2791 3 3 1.000 0.001 HPA:007020_02 hpa 1 cerebral cortex; glial cells[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 4.23e-02 2813 3 3 1.000 0.001 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 4.24e-02 2815 3 3 1.000 0.001 HPA:041020_02 hpa 1 spleen; cells in white pulp[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 4.26e-02 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 Q07666,Q12906,Q08211 346 4.29e-02 6 3 1 0.333 0.167 GO:0070937 CC 1 CRD-mediated mRNA stability complex 1 Q08211 346 4.29e-02 858 3 2 0.667 0.002 HPA:009010_03 hpa 1 colon; endothelial cells[Uncertain,High] 1 Q12906,Q08211 346 4.38e-02 867 3 2 0.667 0.002 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 Q07666,Q12906 346 4.42e-02 871 3 2 0.667 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 Q12906,Q08211 346 4.50e-02 879 3 2 0.667 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q07666,Q12906 346 4.52e-02 2875 3 3 1.000 0.001 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 Q07666,Q12906,Q08211 346 4.55e-02 20 3 1 0.333 0.050 CORUM:1332 cor 1 Large Drosha complex 1 Q12906 346 4.93e-02 75 3 1 0.333 0.013 REAC:975138 rea 1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1 Q08211 346 5.00e-02 7 3 1 0.333 0.143 GO:1903608 BP 1 protein localization to cytoplasmic stress granule 1 Q08211 346 5.00e-02 2974 3 3 1.000 0.001 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 Q07666,Q12906,Q08211 346 5.00e-02 985 3 3 1.000 0.003 TF:M02102_1 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 1 Q07666,Q12906,Q08211 346 5.00e-02 76 3 1 0.333 0.013 REAC:975871 rea 1 MyD88 cascade initiated on plasma membrane 1 Q08211 346 5.00e-02 76 3 1 0.333 0.013 REAC:168181 rea 1 Toll Like Receptor 7/8 (TLR7/8) Cascade 1 Q08211 346 5.00e-02 76 3 1 0.333 0.013 REAC:168142 rea 1 Toll Like Receptor 10 (TLR10) Cascade 1 Q08211 346 5.00e-02 22 3 1 0.333 0.045 CORUM:5615 cor 1 Emerin complex 52 1 Q12906 346 5.00e-02 76 3 1 0.333 0.013 REAC:168176 rea 1 Toll Like Receptor 5 (TLR5) Cascade 1 Q08211 346 5.00e-02 76 3 1 0.333 0.013 REAC:975155 rea 1 MyD88 dependent cascade initiated on endosome 1 Q08211 347 4.27e-10 8 3 3 1.000 0.375 GO:0015377 MF 1 cation:chloride symporter activity 1 P55011,Q9Y666,Q9UP95 347 1.35e-08 23 3 3 1.000 0.130 GO:0015296 MF 1 anion:cation symporter activity 1 P55011,Q9Y666,Q9UP95 347 8.82e-08 7 3 3 1.000 0.429 REAC:426117 rea 1 Cation-coupled Chloride cotransporters 1 P55011,Q9Y666,Q9UP95 347 1.50e-07 50 3 3 1.000 0.060 GO:0015294 MF 1 solute:cation symporter activity 1 P55011,Q9Y666,Q9UP95 347 1.50e-07 50 3 3 1.000 0.060 GO:0015293 MF 1 symporter activity 1 P55011,Q9Y666,Q9UP95 347 2.36e-07 58 3 3 1.000 0.052 GO:0015108 MF 1 chloride transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 4.75e-07 73 3 3 1.000 0.041 GO:0015103 MF 1 inorganic anion transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 5.58e-07 77 3 3 1.000 0.039 GO:0022853 MF 1 active ion transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 8.80e-07 5 3 2 0.667 0.400 GO:0022820 MF 1 potassium ion symporter activity 1 Q9Y666,Q9UP95 347 8.80e-07 5 3 2 0.667 0.400 GO:0015379 MF 1 potassium:chloride symporter activity 1 Q9Y666,Q9UP95 347 1.27e-06 101 3 3 1.000 0.030 GO:0015291 MF 1 secondary active transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 5.92e-06 168 3 3 1.000 0.018 GO:0008509 MF 1 anion transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 8.19e-06 187 3 3 1.000 0.016 GO:0022804 MF 1 active transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 4.91e-05 339 3 3 1.000 0.009 GO:0019901 MF 1 protein kinase binding 1 P55011,Q9Y666,Q9UP95 347 6.08e-05 364 3 3 1.000 0.008 GO:0008324 MF 1 cation transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 7.26e-05 386 3 3 1.000 0.008 GO:0019900 MF 1 kinase binding 1 P55011,Q9Y666,Q9UP95 347 1.10e-04 65 3 3 1.000 0.046 REAC:425393 rea 1 Transport of inorganic cations/anions and amino acids/oligopeptides 1 P55011,Q9Y666,Q9UP95 347 1.58e-04 500 3 3 1.000 0.006 GO:0015075 MF 1 ion transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 1.95e-04 536 3 3 1.000 0.006 GO:0022891 MF 1 substrate-specific transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 2.46e-04 579 3 3 1.000 0.005 GO:0022857 MF 1 transmembrane transporter activity 1 P55011,Q9Y666,Q9UP95 347 3.28e-04 87 3 2 0.667 0.023 GO:0015079 MF 1 potassium ion transmembrane transporter activity 1 Q9Y666,Q9UP95 347 3.61e-04 658 3 3 1.000 0.005 GO:0022892 MF 1 substrate-specific transporter activity 1 P55011,Q9Y666,Q9UP95 347 4.99e-04 733 3 3 1.000 0.004 GO:0006811 BP 1 ion transport 1 P55011,Q9Y666,Q9UP95 347 5.08e-04 1 3 1 0.333 1.000 GO:0070634 BP 1 transepithelial ammonium transport 1 P55011 347 5.35e-04 750 3 3 1.000 0.004 GO:0005215 MF 1 transporter activity 1 P55011,Q9Y666,Q9UP95 347 6.69e-04 808 3 3 1.000 0.004 GO:0005887 CC 1 integral component of plasma membrane 1 P55011,Q9Y666,Q9UP95 347 7.59e-04 843 3 3 1.000 0.004 GO:0031226 CC 1 intrinsic component of plasma membrane 1 P55011,Q9Y666,Q9UP95 347 1.02e-03 2 3 1 0.333 0.500 GO:0008511 MF 1 sodium:potassium:chloride symporter activity 1 P55011 347 1.52e-03 3 3 1 0.333 0.333 GO:0030321 BP 1 transepithelial chloride transport 1 P55011 347 1.60e-03 192 3 2 0.667 0.010 GO:0015077 MF 1 monovalent inorganic cation transmembrane transporter activity 1 Q9Y666,Q9UP95 347 2.36e-03 1230 3 3 1.000 0.002 GO:0019899 MF 1 enzyme binding 1 P55011,Q9Y666,Q9UP95 347 2.41e-03 180 3 3 1.000 0.017 REAC:425407 rea 1 SLC-mediated transmembrane transport 1 P55011,Q9Y666,Q9UP95 347 2.54e-03 5 3 1 0.333 0.200 GO:0070633 BP 1 transepithelial transport 1 P55011 347 2.61e-03 1272 3 3 1.000 0.002 GO:0044459 CC 1 plasma membrane part 1 P55011,Q9Y666,Q9UP95 347 2.79e-03 254 3 2 0.667 0.008 GO:0046873 MF 1 metal ion transmembrane transporter activity 1 Q9Y666,Q9UP95 347 3.12e-03 269 3 2 0.667 0.007 GO:0007268 BP 1 chemical synaptic transmission 1 Q9Y666,Q9UP95 347 3.12e-03 269 3 2 0.667 0.007 GO:0099537 BP 1 trans-synaptic signaling 1 Q9Y666,Q9UP95 347 3.12e-03 269 3 2 0.667 0.007 GO:0099536 BP 1 synaptic signaling 1 Q9Y666,Q9UP95 347 3.12e-03 269 3 2 0.667 0.007 GO:0098916 BP 1 anterograde trans-synaptic signaling 1 Q9Y666,Q9UP95 347 3.42e-03 1392 3 3 1.000 0.002 GO:0016021 CC 1 integral component of membrane 1 P55011,Q9Y666,Q9UP95 347 3.79e-03 1440 3 3 1.000 0.002 GO:0031224 CC 1 intrinsic component of membrane 1 P55011,Q9Y666,Q9UP95 347 4.01e-03 305 3 2 0.667 0.007 GO:0022890 MF 1 inorganic cation transmembrane transporter activity 1 Q9Y666,Q9UP95 347 4.57e-03 9 3 1 0.333 0.111 GO:0006884 BP 1 cell volume homeostasis 1 Q9UP95 347 6.09e-03 12 3 1 0.333 0.083 GO:0008519 MF 1 ammonium transmembrane transporter activity 1 P55011 347 1.28e-02 2527 3 3 1.000 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 P55011,Q9Y666,Q9UP95 347 1.37e-02 2585 3 3 1.000 0.001 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 P55011,Q9Y666,Q9UP95 347 1.78e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 P55011,Q9Y666,Q9UP95 347 1.80e-02 2420 3 3 1.000 0.001 GO:0005886 CC 1 plasma membrane 1 P55011,Q9Y666,Q9UP95 347 1.82e-02 36 3 1 0.333 0.028 GO:0015696 BP 1 ammonium transport 1 P55011 347 1.85e-02 872 3 2 0.667 0.002 HPA:040020_02 hpa 1 soft tissue 2; chondrocytes[Uncertain,Medium] 1 Q9Y666,Q9UP95 347 1.91e-02 2469 3 3 1.000 0.001 GO:0071944 CC 1 cell periphery 1 P55011,Q9Y666,Q9UP95 347 2.16e-02 945 3 2 0.667 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P55011,Q9Y666 347 2.18e-02 43 3 1 0.333 0.023 GO:0006821 BP 1 chloride transport 1 P55011 347 2.35e-02 2644 3 3 1.000 0.001 GO:0006810 BP 1 transport 1 P55011,Q9Y666,Q9UP95 347 2.39e-02 754 3 2 0.667 0.003 GO:0007267 BP 1 cell-cell signaling 1 Q9Y666,Q9UP95 347 2.64e-02 2748 3 3 1.000 0.001 GO:0051234 BP 1 establishment of localization 1 P55011,Q9Y666,Q9UP95 347 2.73e-02 54 3 1 0.333 0.019 GO:0015698 BP 1 inorganic anion transport 1 P55011 347 3.58e-02 71 3 1 0.333 0.014 GO:0008361 BP 1 regulation of cell size 1 Q9UP95 347 4.28e-02 85 3 1 0.333 0.012 GO:0016324 CC 1 apical plasma membrane 1 P55011 347 4.48e-02 1380 3 2 0.667 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q9Y666,Q9UP95 347 4.66e-02 1408 3 2 0.667 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 P55011,Q9Y666 347 4.71e-02 3899 3 3 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 P55011,Q9Y666,Q9UP95 347 5.00e-02 493 3 3 1.000 0.006 REAC:382551 rea 1 Transmembrane transport of small molecules 1 P55011,Q9Y666,Q9UP95 347 5.00e-02 313 3 2 0.667 0.006 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 Q9Y666,Q9UP95 347 5.00e-02 23 3 1 0.333 0.043 KEGG:04966 keg 1 Collecting duct acid secretion 1 Q9Y666 347 5.00e-02 3401 3 3 1.000 0.001 GO:0051179 BP 1 localization 1 P55011,Q9Y666,Q9UP95 348 4.39e-03 5478 8 8 1.000 0.001 HPA:029010_01 hpa 1 placenta; decidual cells[Uncertain,Low] 1 P36551,P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3,O14907 348 7.20e-03 1 8 1 0.125 1.000 OMIM:121300 omi 1 COPROPORPHYRIA, HEREDITARY; HCP;;COPROPORPHYRINOGEN OXIDASE DEFICIENCY;;CPOX DEFICIENCY;;CPO DEFICIENCY;;CPX DEFICIENCYHARDEROPORPHYRIA, INCLUDED 1 P36551 348 7.20e-03 1 8 1 0.125 1.000 OMIM:616501 omi 1 CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASEDEFICIENCY 4; CEMCOX4 1 Q5JTJ3 348 8.19e-03 4293 8 7 0.875 0.002 HPA:004030_02 hpa 1 breast; myoepithelial cells[Uncertain,Medium] 1 P36551,P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3 348 8.94e-03 58 8 2 0.250 0.034 TF:M06232_0 tf 1 Factor: ZNF234; motif: NGTGCAAAAYKG; match class: 0 1 P36551,Q5JTJ3 348 9.20e-03 2 8 1 0.125 0.500 HP:0003489 hp 1 Acute episodes of neuropathic symptoms 1 P36551 348 1.38e-02 3 8 1 0.125 0.333 HP:0004357 hp 1 Abnormality of leucine metabolism 1 P38117 348 1.38e-02 3 8 1 0.125 0.333 HP:0003647 hp 1 Electron transfer flavoprotein-ubiquinone oxidoreductase defect 1 P38117 348 1.38e-02 3 8 1 0.125 0.333 HP:0002614 hp 1 Hepatic periportal necrosis 1 P38117 348 1.38e-02 3 8 1 0.125 0.333 HP:0003490 hp 1 Defective dehydrogenation of isovaleryl CoA and butyryl CoA 1 P38117 348 1.38e-02 3 8 1 0.125 0.333 HP:0002203 hp 1 Respiratory paralysis 1 P36551 348 1.43e-02 3386 8 6 0.750 0.002 HPA:006030_02 hpa 1 cerebellum; cells in molecular layer[Uncertain,Medium] 1 P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3 348 1.64e-02 275 8 2 0.250 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 P38117,Q9Y376 348 1.75e-02 8 8 1 0.125 0.125 REAC:5666185 rea 1 RHO GTPases Activate Rhotekin and Rhophilins 1 O14907 348 1.76e-02 6515 8 8 1.000 0.001 HPA:029010 hpa 1 placenta; decidual cells 1 P36551,P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3,O14907 348 1.83e-02 4 8 1 0.125 0.250 HP:0003530 hp 1 Glutaric acidemia 1 P38117 348 1.83e-02 4 8 1 0.125 0.250 HP:0004804 hp 1 Congenital hemolytic anemia 1 P36551 348 1.88e-02 49 8 2 0.250 0.041 GO:0005758 CC 1 mitochondrial intermembrane space 1 P36551,Q5JTJ3 348 2.15e-02 3 8 1 0.125 0.333 OMIM:231680 omi 1 MULTIPLE ACYL-CoA DEHYDROGENASE DEFICIENCY; MADD;;GLUTARIC ACIDEMIA II;;GLUTARIC ACIDURIA II;;GA II;;ETHYLMALONIC-ADIPICACIDURIA; EMAGLUTARIC ACIDEMIA IIA, INCLUDED;;ETFA DEFICIENCY, INCLUDED;;GLUTARIC ACIDEMIA IIB, INCLUDED;;ETFB DEFICIENCY, INCLUDED;;GLUTARIC ACIDEMIA IIC, INCLUDED;;ETFDH DEFICIENCY, INCLUDED 1 P38117 348 2.19e-02 10 8 1 0.125 0.100 REAC:189451 rea 1 Heme biosynthesis 1 P36551 348 2.20e-02 53 8 2 0.250 0.038 GO:0031970 CC 1 organelle envelope lumen 1 P36551,Q5JTJ3 348 2.57e-02 930 8 3 0.375 0.003 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P38117,P31937,Q9Y376 348 2.58e-02 674 8 4 0.500 0.006 GO:0044429 CC 1 mitochondrial part 1 P36551,P38117,P31937,Q5JTJ3 348 2.63e-02 1722 8 4 0.500 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P38117,P31937,Q15843,Q5JTJ3 348 2.68e-02 1 8 1 0.125 1.000 GO:0017133 CC 1 mitochondrial electron transfer flavoprotein complex 1 P38117 348 2.68e-02 1 8 1 0.125 1.000 GO:0008442 MF 1 3-hydroxyisobutyrate dehydrogenase activity 1 P31937 348 2.68e-02 1 8 1 0.125 1.000 GO:0045251 CC 1 electron transfer flavoprotein complex 1 P38117 348 2.68e-02 1 8 1 0.125 1.000 GO:0042774 BP 1 plasma membrane ATP synthesis coupled electron transport 1 Q5JTJ3 348 2.68e-02 1 8 1 0.125 1.000 GO:0004109 MF 1 coproporphyrinogen oxidase activity 1 P36551 348 2.75e-02 6 8 1 0.125 0.167 HP:0003219 hp 1 Ethylmalonic aciduria 1 P38117 348 2.75e-02 6 8 1 0.125 0.167 HP:0006597 hp 1 Diaphragmatic paralysis 1 P36551 348 2.75e-02 6889 8 8 1.000 0.001 HPA:001010_02 hpa 1 adrenal gland; glandular cells[Uncertain,Medium] 1 P36551,P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3,O14907 348 2.78e-02 958 8 3 0.375 0.003 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P38117,P31937,Q9Y376 348 2.84e-02 73 8 2 0.250 0.027 HP:0001397 hp 1 Hepatic steatosis 1 P38117,Q5JTJ3 348 2.87e-02 4 8 1 0.125 0.250 OMIM:604377 omi 1 Fatal Infantile Cardioencephalomyopathy Due to Cytochrome c Oxidase Deficiency 1 Q5JTJ3 348 3.00e-02 3 8 1 0.125 0.333 TF:M06775_1 tf 1 Factor: ZNF391; motif: NGGGTGAGGGTC; match class: 1 1 P38117 348 3.01e-02 3 8 1 0.125 0.333 CORUM:6053 cor 1 LKB1-STRAD-MO25 complex 1 Q9Y376 348 3.06e-02 14 8 1 0.125 0.071 REAC:140837 rea 1 Intrinsic Pathway of Fibrin Clot Formation 1 P42785 348 3.10e-02 3931 8 6 0.750 0.002 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 P36551,P38117,P31937,Q15843,Q9Y376,Q5JTJ3 348 3.20e-02 7 8 1 0.125 0.143 HP:0009113 hp 1 Diaphragmatic weakness 1 P36551 348 3.20e-02 7 8 1 0.125 0.143 HP:0002909 hp 1 Generalized aminoaciduria 1 P38117 348 3.46e-02 5386 8 7 0.875 0.001 HPA:032010_02 hpa 1 salivary gland; glandular cells[Uncertain,Medium] 1 P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3,O14907 348 3.49e-02 16 8 1 0.125 0.062 REAC:189445 rea 1 Metabolism of porphyrins 1 P36551 348 3.58e-02 1055 8 3 0.375 0.003 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 P31937,Q9Y376,P42785 348 3.62e-02 83 8 2 0.250 0.024 HP:0006561 hp 1 Lipid accumulation in hepatocytes 1 P38117,Q5JTJ3 348 3.65e-02 8 8 1 0.125 0.125 HP:0010892 hp 1 Abnormality of branched chain family amino acid metabolism 1 P38117 348 3.87e-02 86 8 2 0.250 0.023 HP:0000952 hp 1 Jaundice 1 P36551,P38117 348 3.99e-02 1100 8 3 0.375 0.003 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P38117,P31937,Q9Y376 348 4.06e-02 1107 8 3 0.375 0.003 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 P38117,P31937,Q9Y376 348 4.10e-02 9 8 1 0.125 0.111 HP:0001325 hp 1 Hypoglycemic coma 1 P38117 348 4.10e-02 9 8 1 0.125 0.111 HP:0003150 hp 1 Glutaric aciduria 1 P38117 348 4.14e-02 4163 8 6 0.750 0.001 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 P38117,P31937,Q15843,Q9Y376,P42785,Q5JTJ3 348 4.25e-02 485 8 3 0.375 0.006 TF:M00495_0 tf 1 Factor: Bach1; motif: NNSATGAGTCATGNT; match class: 0 1 P36551,P31937,Q15843 348 4.25e-02 485 8 3 0.375 0.006 TF:M04213_0 tf 1 Factor: JDP2; motif: ATGACTCAT; match class: 0 1 P36551,P31937,Q15843 348 4.55e-02 10 8 1 0.125 0.100 HP:0100785 hp 1 Insomnia 1 P36551 348 4.55e-02 10 8 1 0.125 0.100 HP:0006999 hp 1 Basal ganglia gliosis 1 Q5JTJ3 348 4.55e-02 476 8 2 0.250 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P38117,P31937 348 4.78e-02 489 8 2 0.250 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P31937,Q9Y376 348 4.97e-02 2079 8 4 0.500 0.002 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 P38117,Q15843,Q9Y376,P42785 348 5.00e-02 7 8 1 0.125 0.143 OMIM:607426 omi 1 Primary Coenzyme Q10 Deficiency 1 P38117 348 5.00e-02 11 8 1 0.125 0.091 HP:0001289 hp 1 Confusion 1 P36551 348 5.00e-02 23 8 1 0.125 0.043 REAC:70895 rea 1 Branched-chain amino acid catabolism 1 P31937 348 5.00e-02 397 8 3 0.375 0.008 MI:hsa-miR-200a* mi 1 MI:hsa-miR-200a* 1 P36551,P31937,P42785 348 5.00e-02 11 8 1 0.125 0.091 HP:0007941 hp 1 Limited extraocular movements 1 Q5JTJ3 348 5.00e-02 23 8 1 0.125 0.043 REAC:140877 rea 1 Formation of Fibrin Clot (Clotting Cascade) 1 P42785 348 5.00e-02 5 8 1 0.125 0.200 TF:M04537_0 tf 1 Factor: SOX21; motif: TCAATGNTATTGA; match class: 0 1 Q5JTJ3 348 5.00e-02 5 8 1 0.125 0.200 TF:M05840_0 tf 1 Factor: APA1; motif: NGTTKCTAAACY; match class: 0 1 Q15843 348 5.00e-02 5 8 1 0.125 0.200 CORUM:2188 cor 1 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) 1 Q15843 348 5.00e-02 15 8 1 0.125 0.067 KEGG:04614 keg 1 Renin-angiotensin system 1 P42785 349 1.37e-03 3 2 1 0.500 0.333 KEGG:00780 keg 1 Biotin metabolism 1 P43251 349 2.34e-03 4 2 1 0.500 0.250 REAC:8853383 rea 1 Lysosomal oligosaccharide catabolism 1 O00462 349 3.85e-03 1 2 1 0.500 1.000 GO:0004567 MF 1 beta-mannosidase activity 1 O00462 349 6.43e-03 11 2 1 0.500 0.091 REAC:196780 rea 1 Biotin transport and metabolism 1 P43251 349 6.82e-03 15 2 1 0.500 0.067 KEGG:04977 keg 1 Vitamin digestion and absorption 1 P43251 349 7.70e-03 2 2 1 0.500 0.500 GO:0047708 MF 1 biotinidase activity 1 P43251 349 7.73e-03 17 2 1 0.500 0.059 KEGG:00511 keg 1 Other glycan degradation 1 O00462 349 2.69e-02 7 2 1 0.500 0.143 GO:0009313 BP 1 oligosaccharide catabolic process 1 O00462 349 3.18e-02 418 2 2 1.000 0.005 MI:hsa-miR-100 mi 1 MI:hsa-miR-100 1 O00462,P43251 349 3.95e-02 1 2 1 0.500 1.000 HP:0100275 hp 1 Diffuse cerebellar atrophy 1 P43251 349 4.53e-02 20 2 1 0.500 0.050 TF:M06676_0 tf 1 Factor: ZNF665; motif: NGGTAAAAATGC; match class: 0 1 O00462 349 4.53e-02 20 2 1 0.500 0.050 TF:M01203_1 tf 1 Factor: SPI1; motif: NNAAWGNGGAASTNNNN; match class: 1 1 O00462 349 5.00e-02 13 2 1 0.500 0.077 GO:0006768 BP 1 biotin metabolic process 1 P43251 349 5.00e-02 1 2 1 0.500 1.000 OMIM:253260 omi 1 BIOTINIDASE DEFICIENCYMULTIPLE CARBOXYLASE DEFICIENCY, LATE-ONSET;;MULTIPLE CARBOXYLASE DEFICIENCY, JUVENILE-ONSET;;BTD DEFICIENCY 1 P43251 349 5.00e-02 1 2 1 0.500 1.000 OMIM:248510 omi 1 MANNOSIDOSIS, BETA A, LYSOSOMAL; MANSB;;BETA-MANNOSIDOSIS;;LYSOSOMAL BETA-MANNOSIDASE DEFICIENCY;;BETA-MANNOSIDASE DEFICIENCY 1 O00462 349 5.00e-02 83 2 2 1.000 0.024 HP:0000502 hp 1 Abnormality of the conjunctiva 1 O00462,P43251 349 5.00e-02 111 2 1 0.500 0.009 KEGG:04142 keg 1 Lysosome 1 O00462 349 5.00e-02 750 2 2 1.000 0.003 TF:M01127_1 tf 1 Factor: islet1; motif: GSNTAATRK; match class: 1 1 O00462,P43251 349 5.00e-02 86 2 1 0.500 0.012 REAC:196849 rea 1 Metabolism of water-soluble vitamins and cofactors 1 P43251 349 5.00e-02 524 2 2 1.000 0.004 MI:mmu-miR-467d mi 1 MI:mmu-miR-467d 1 O00462,P43251 350 7.24e-08 2 2 2 1.000 1.000 GO:0047179 MF 1 platelet-activating factor acetyltransferase activity 1 Q15102,P68402 350 7.61e-06 15 2 2 1.000 0.133 GO:0004623 MF 1 phospholipase A2 activity 1 Q15102,P68402 350 3.70e-05 29 2 2 1.000 0.069 KEGG:00565 keg 1 Ether lipid metabolism 1 Q15102,P68402 350 1.20e-04 58 2 2 1.000 0.034 GO:0004620 MF 1 phospholipase activity 1 Q15102,P68402 350 1.35e-04 29 2 2 1.000 0.069 REAC:6811436 rea 1 COPI-independent Golgi-to-ER retrograde traffic 1 Q15102,P68402 350 1.51e-04 65 2 2 1.000 0.031 GO:0052689 MF 1 carboxylic ester hydrolase activity 1 Q15102,P68402 350 1.85e-04 72 2 2 1.000 0.028 GO:0016298 MF 1 lipase activity 1 Q15102,P68402 350 2.41e-04 82 2 2 1.000 0.024 GO:0016407 MF 1 acetyltransferase activity 1 Q15102,P68402 350 8.87e-04 157 2 2 1.000 0.013 GO:0016747 MF 1 transferase activity, transferring acyl groups other than amino-acyl groups 1 Q15102,P68402 350 1.12e-03 176 2 2 1.000 0.011 GO:0016746 MF 1 transferase activity, transferring acyl groups 1 Q15102,P68402 350 1.59e-03 210 2 2 1.000 0.010 GO:0007420 BP 1 brain development 1 Q15102,P68402 350 1.73e-03 219 2 2 1.000 0.009 GO:0060322 BP 1 head development 1 Q15102,P68402 350 1.75e-03 469 2 2 1.000 0.004 MI:hsa-miR-377 mi 1 MI:hsa-miR-377 1 Q15102,P68402 350 1.88e-03 107 2 2 1.000 0.019 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 Q15102,P68402 350 3.40e-03 307 2 2 1.000 0.007 GO:0007417 BP 1 central nervous system development 1 Q15102,P68402 350 4.83e-03 171 2 2 1.000 0.012 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 Q15102,P68402 350 5.50e-03 944 2 2 1.000 0.002 TF:M01657_0 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 0 1 Q15102,P68402 350 7.06e-03 45 2 1 0.500 0.022 TF:M07090_0 tf 1 Factor: c-Fos; motif: NNTGASTCATN; match class: 0 1 P68402 350 8.94e-03 57 2 1 0.500 0.018 TF:M06694_0 tf 1 Factor: ZNF160; motif: NGGTCAGCCAGC; match class: 0 1 P68402 350 9.18e-03 504 2 2 1.000 0.004 GO:0016788 MF 1 hydrolase activity, acting on ester bonds 1 Q15102,P68402 350 9.72e-03 62 2 1 0.500 0.016 TF:M01163_0 tf 1 Factor: Elk-1; motif: AACCGGAAGTR; match class: 0 1 P68402 350 9.88e-03 63 2 1 0.500 0.016 TF:M06611_0 tf 1 Factor: ZNF560; motif: NNGTGGGKCAGC; match class: 0 1 Q15102 350 1.33e-02 85 2 1 0.500 0.012 TF:M00634_1 tf 1 Factor: GCM; motif: CNNRCCCGCATD; match class: 1 1 P68402 350 1.38e-02 88 2 1 0.500 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 Q15102 350 1.46e-02 93 2 1 0.500 0.011 TF:M00114_0 tf 1 Factor: Tax/CREB; motif: GGGGGTTGACGYANA; match class: 0 1 P68402 350 1.80e-02 115 2 1 0.500 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 P68402 350 2.12e-02 765 2 2 1.000 0.003 GO:0006629 BP 1 lipid metabolic process 1 Q15102,P68402 350 2.30e-02 147 2 1 0.500 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 P68402 350 2.42e-02 155 2 1 0.500 0.006 TF:M06428_0 tf 1 Factor: ZNF227; motif: NKGTAAAAAASM; match class: 0 1 P68402 350 2.50e-02 30 2 1 0.500 0.033 GO:0016239 BP 1 positive regulation of macroautophagy 1 P68402 350 2.68e-02 172 2 1 0.500 0.006 TF:M01204_0 tf 1 Factor: Spi-B; motif: AAAAWGMGGAAGTWNSN; match class: 0 1 P68402 350 2.75e-02 176 2 1 0.500 0.006 TF:M03869_1 tf 1 Factor: Fra-1; motif: TGACTCAN; match class: 1 1 P68402 350 2.75e-02 176 2 1 0.500 0.006 TF:M03552_1 tf 1 Factor: JunD; motif: TGACTCAN; match class: 1 1 P68402 350 2.75e-02 176 2 1 0.500 0.006 TF:M03538_1 tf 1 Factor: AP-1; motif: TGACTCAN; match class: 1 1 P68402 350 2.81e-02 180 2 1 0.500 0.006 TF:M04143_0 tf 1 Factor: TEAD3; motif: RCATTCCNNRCATWCCN; match class: 0 1 P68402 350 2.84e-02 182 2 1 0.500 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 Q15102 350 3.02e-02 2213 2 2 1.000 0.001 TF:M00724_1 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 1 1 Q15102,P68402 350 3.12e-02 200 2 1 0.500 0.005 TF:M01752_1 tf 1 Factor: ERG; motif: ACCGGAART; match class: 1 1 P68402 350 3.22e-02 943 2 2 1.000 0.002 GO:0007399 BP 1 nervous system development 1 Q15102,P68402 350 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 Q15102,P68402 350 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 Q15102 350 4.15e-02 267 2 1 0.500 0.004 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 P68402 350 4.15e-02 267 2 1 0.500 0.004 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 P68402 350 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 P68402 350 4.48e-02 1113 2 2 1.000 0.002 GO:0048513 BP 1 animal organ development 1 Q15102,P68402 350 4.51e-02 2702 2 2 1.000 0.001 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 Q15102,P68402 350 4.52e-02 522 2 2 1.000 0.004 REAC:199991 rea 1 Membrane Trafficking 1 Q15102,P68402 350 4.74e-02 305 2 1 0.500 0.003 TF:M00930_1 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 1 1 P68402 350 4.77e-02 307 2 1 0.500 0.003 TF:M01816_1 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 1 P68402 350 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 P68402 350 4.92e-02 317 2 1 0.500 0.003 TF:M03982_1 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 1 P68402 350 5.00e-02 60 2 1 0.500 0.017 GO:0010508 BP 1 positive regulation of autophagy 1 P68402 350 5.00e-02 549 2 2 1.000 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q15102,P68402 350 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 Q15102,P68402 351 4.61e-08 409 6 6 1.000 0.015 GO:0005813 CC 1 centrosome 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 1.12e-07 474 6 6 1.000 0.013 GO:0005815 CC 1 microtubule organizing center 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 2.07e-06 769 6 6 1.000 0.008 GO:0015630 CC 1 microtubule cytoskeleton 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 6.63e-06 933 6 6 1.000 0.006 GO:0044430 CC 1 cytoskeletal part 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 3.08e-05 1204 6 6 1.000 0.005 GO:0005856 CC 1 cytoskeleton 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 5.75e-04 1960 6 6 1.000 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 5.75e-04 1960 6 6 1.000 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q969Q6,Q5VT06,Q5JTW2,Q96LK0,Q2KHM9,O95684 351 1.37e-03 66 6 2 0.333 0.030 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 Q5JTW2,O95684 351 1.37e-03 66 6 2 0.333 0.030 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 Q5JTW2,O95684 351 1.49e-03 69 6 2 0.333 0.029 REAC:8854518 rea 1 AURKA Activation by TPX2 1 Q5JTW2,O95684 351 1.76e-03 75 6 2 0.333 0.027 REAC:380287 rea 1 Centrosome maturation 1 Q5JTW2,O95684 351 1.76e-03 75 6 2 0.333 0.027 REAC:380270 rea 1 Recruitment of mitotic centrosome proteins and complexes 1 Q5JTW2,O95684 351 2.16e-03 83 6 2 0.333 0.024 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 Q5JTW2,O95684 351 2.64e-03 92 6 2 0.333 0.022 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 Q5JTW2,O95684 351 8.91e-03 171 6 2 0.333 0.012 REAC:69275 rea 1 G2/M Transition 1 Q5JTW2,O95684 351 9.11e-03 173 6 2 0.333 0.012 REAC:5617833 rea 1 Assembly of the primary cilium 1 Q5JTW2,O95684 351 9.11e-03 173 6 2 0.333 0.012 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 Q5JTW2,O95684 351 1.15e-02 1941 6 4 0.667 0.002 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q969Q6,Q5VT06,Q5JTW2,Q2KHM9 351 1.28e-02 341 6 2 0.333 0.006 MI:hsa-miR-19a* mi 1 MI:hsa-miR-19a* 1 Q969Q6,Q5JTW2 351 1.68e-02 393 6 2 0.333 0.005 MI:hsa-miR-578 mi 1 MI:hsa-miR-578 1 Q5JTW2,Q2KHM9 351 1.69e-02 18 6 1 0.167 0.056 REAC:1839117 rea 1 Signaling by cytosolic FGFR1 fusion mutants 1 O95684 351 1.71e-02 397 6 2 0.333 0.005 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 Q5JTW2,O95684 351 1.73e-02 399 6 2 0.333 0.005 MI:hsa-miR-410 mi 1 MI:hsa-miR-410 1 Q969Q6,O95684 351 1.94e-02 424 6 2 0.333 0.005 MI:hsa-miR-361-5p mi 1 MI:hsa-miR-361-5p 1 Q5JTW2,O95684 351 1.97e-02 428 6 2 0.333 0.005 MI:hsa-miR-936 mi 1 MI:hsa-miR-936 1 Q2KHM9,O95684 351 2.23e-02 4 6 1 0.167 0.250 HP:0000798 hp 1 Oligospermia 1 Q96LK0 351 2.23e-02 4 6 1 0.167 0.250 HP:0003141 hp 1 Hyperbetalipoproteinemia 1 Q96LK0 351 2.34e-02 25 6 1 0.167 0.040 REAC:1839124 rea 1 FGFR1 mutant receptor activation 1 O95684 351 2.86e-02 314 6 2 0.333 0.006 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 Q5JTW2,O95684 351 2.99e-02 32 6 1 0.167 0.031 REAC:5655302 rea 1 Signaling by FGFR1 in disease 1 O95684 351 3.40e-02 114 6 2 0.333 0.018 GO:0044450 CC 1 microtubule organizing center part 1 Q96LK0,Q2KHM9 351 3.55e-02 564 6 2 0.333 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q5VT06,Q2KHM9 351 4.28e-02 624 6 2 0.333 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q5VT06,Q2KHM9 351 4.66e-02 653 6 2 0.333 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 Q5VT06,Q2KHM9 351 5.00e-02 510 6 3 0.500 0.006 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 Q969Q6,Q5JTW2,Q96LK0 351 5.00e-02 1 6 1 0.167 1.000 OMIM:615703 omi 1 MORBID OBESITY AND SPERMATOGENIC FAILURE; MOSPGF 1 Q96LK0 351 5.00e-02 9 6 1 0.167 0.111 HP:0003233 hp 1 Hypoalphalipoproteinemia 1 Q96LK0 351 5.00e-02 4 6 1 0.167 0.250 GO:0030292 MF 1 protein tyrosine kinase inhibitor activity 1 O95684 351 5.00e-02 54 6 1 0.167 0.019 REAC:1226099 rea 1 Signaling by FGFR in disease 1 O95684 352 4.08e-03 26 2 1 0.500 0.038 TF:M07104_0 tf 1 Factor: JunD; motif: NRTGASTCATN; match class: 0 1 Q96IY4 352 4.40e-03 28 2 1 0.500 0.036 TF:M04207_0 tf 1 Factor: CREB3; motif: NTGCCACGTCAYCN; match class: 0 1 Q96IY4 352 4.87e-03 31 2 1 0.500 0.032 TF:M05758_0 tf 1 Factor: ZNF699; motif: NGKATYAAAATA; match class: 0 1 Q9BS40 352 5.02e-03 32 2 1 0.500 0.031 TF:M06613_0 tf 1 Factor: ZNF514; motif: NGTTGATTMAGM; match class: 0 1 Q96IY4 352 9.26e-03 1225 2 2 1.000 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 Q9BS40,Q96IY4 352 9.35e-03 11 2 1 0.500 0.091 REAC:2022377 rea 1 Metabolism of Angiotensinogen to Angiotensins 1 Q96IY4 352 1.21e-02 77 2 1 0.500 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 Q9BS40 352 1.39e-02 89 2 1 0.500 0.011 TF:M06132_0 tf 1 Factor: ZNF823; motif: NYYACCAGCCCT; match class: 0 1 Q96IY4 352 1.70e-02 1659 2 2 1.000 0.001 TF:M01013_0 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 0 1 Q9BS40,Q96IY4 352 1.72e-02 110 2 1 0.500 0.009 TF:M04058_0 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 0 1 Q96IY4 352 1.74e-02 111 2 1 0.500 0.009 TF:M04000_0 tf 1 Factor: GCM1; motif: ATRCKGGTRCCMGCAN; match class: 0 1 Q96IY4 352 1.86e-02 119 2 1 0.500 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 Q96IY4 352 2.08e-02 1835 2 2 1.000 0.001 TF:M00406_0 tf 1 Factor: MEF-2A; motif: SKYTAAAAATAACYCH; match class: 0 1 Q9BS40,Q96IY4 352 2.32e-02 1939 2 2 1.000 0.001 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 Q9BS40,Q96IY4 352 2.38e-02 1962 2 2 1.000 0.001 TF:M01595_0 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 0 1 Q9BS40,Q96IY4 352 2.49e-02 2008 2 2 1.000 0.001 TF:M04442_1 tf 1 Factor: UNCX; motif: NTAATNNAATTAN; match class: 1 1 Q9BS40,Q96IY4 352 2.59e-02 2050 2 2 1.000 0.001 TF:M00216_1 tf 1 Factor: TATA; motif: NCTATAAAAR; match class: 1 1 Q9BS40,Q96IY4 352 2.71e-02 372 2 2 1.000 0.005 MI:mmu-miR-704 mi 1 MI:mmu-miR-704 1 Q9BS40,Q96IY4 352 2.86e-02 20 2 1 0.500 0.050 GO:0042730 BP 1 fibrinolysis 1 Q96IY4 352 2.89e-02 2166 2 2 1.000 0.001 TF:M03891_1 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 1 1 Q9BS40,Q96IY4 352 2.93e-02 188 2 1 0.500 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q96IY4 352 2.93e-02 188 2 1 0.500 0.005 TF:M00406_1 tf 1 Factor: MEF-2A; motif: SKYTAAAAATAACYCH; match class: 1 1 Q96IY4 352 2.95e-02 189 2 1 0.500 0.005 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 Q96IY4 352 3.00e-02 2204 2 2 1.000 0.001 TF:M01029_0 tf 1 Factor: TFE; motif: TCATGTGN; match class: 0 1 Q9BS40,Q96IY4 352 3.15e-02 2261 2 2 1.000 0.001 TF:M03548_0 tf 1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 0 1 Q9BS40,Q96IY4 352 3.17e-02 2267 2 2 1.000 0.001 TF:M07390_1 tf 1 Factor: Nfe2l1; motif: TGYNNAGTCATT; match class: 1 1 Q9BS40,Q96IY4 352 3.18e-02 2270 2 2 1.000 0.001 TF:M01739_0 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 0 1 Q9BS40,Q96IY4 352 3.21e-02 2282 2 2 1.000 0.001 TF:M04361_0 tf 1 Factor: HOXD12; motif: GTAATAAAA; match class: 0 1 Q9BS40,Q96IY4 352 3.28e-02 409 2 2 1.000 0.005 MI:hsa-miR-641 mi 1 MI:hsa-miR-641 1 Q9BS40,Q96IY4 352 3.40e-02 218 2 1 0.500 0.005 TF:M00152_0 tf 1 Factor: SRF; motif: ATGCCCATATATGGWNNT; match class: 0 1 Q96IY4 352 3.43e-02 24 2 1 0.500 0.042 GO:0004181 MF 1 metallocarboxypeptidase activity 1 Q96IY4 352 3.74e-02 2461 2 2 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q9BS40,Q96IY4 352 3.89e-02 2510 2 2 1.000 0.001 TF:M00691_0 tf 1 Factor: ATF1; motif: CYYTGACGTCA; match class: 0 1 Q9BS40,Q96IY4 352 3.89e-02 2511 2 2 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q9BS40,Q96IY4 352 3.92e-02 2519 2 2 1.000 0.001 TF:M00744_1 tf 1 Factor: POU1F1; motif: ATGAATAAWT; match class: 1 1 Q9BS40,Q96IY4 352 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q96IY4 352 4.06e-02 261 2 1 0.500 0.004 TF:M00538_0 tf 1 Factor: HTF; motif: NNWWWWNGMCACGTCATYNYWNNN; match class: 0 1 Q96IY4 352 4.13e-02 2588 2 2 1.000 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 Q9BS40,Q96IY4 352 4.23e-02 2618 2 2 1.000 0.001 TF:M04421_0 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 0 1 Q9BS40,Q96IY4 352 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 Q9BS40,Q96IY4 352 4.43e-02 31 2 1 0.500 0.032 GO:1900047 BP 1 negative regulation of hemostasis 1 Q96IY4 352 4.43e-02 31 2 1 0.500 0.032 GO:0030195 BP 1 negative regulation of blood coagulation 1 Q96IY4 352 4.52e-02 291 2 1 0.500 0.003 TF:M00436_1 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 1 1 Q96IY4 352 4.61e-02 485 2 2 1.000 0.004 MI:mmu-miR-743b-3p mi 1 MI:mmu-miR-743b-3p 1 Q9BS40,Q96IY4 352 4.62e-02 2737 2 2 1.000 0.001 TF:M01255_0 tf 1 Factor: ipf1; motif: RNWCATTAANWN; match class: 0 1 Q9BS40,Q96IY4 352 4.64e-02 299 2 1 0.500 0.003 TF:M05619_0 tf 1 Factor: ZSCAN5C; motif: NMGTTWAACATG; match class: 0 1 Q96IY4 352 4.66e-02 300 2 1 0.500 0.003 TF:M01182_0 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 0 1 Q9BS40 352 4.71e-02 33 2 1 0.500 0.030 GO:0050819 BP 1 negative regulation of coagulation 1 Q96IY4 352 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 Q9BS40 352 4.80e-02 309 2 1 0.500 0.003 TF:M05390_0 tf 1 Factor: TBPL2; motif: CTTTTAAATC; match class: 0 1 Q9BS40 352 4.89e-02 315 2 1 0.500 0.003 TF:M00740_1 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 1 Q96IY4 352 4.89e-02 2816 2 2 1.000 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 Q9BS40,Q96IY4 352 4.92e-02 501 2 2 1.000 0.004 MI:mmu-miR-465a-3p mi 1 MI:mmu-miR-465a-3p 1 Q9BS40,Q96IY4 352 5.00e-02 35 2 1 0.500 0.029 GO:0004180 MF 1 carboxypeptidase activity 1 Q96IY4 352 5.00e-02 48 2 1 0.500 0.021 KEGG:04610 keg 1 Complement and coagulation cascades 1 Q96IY4 352 5.00e-02 59 2 1 0.500 0.017 REAC:2980736 rea 1 Peptide hormone metabolism 1 Q96IY4 352 5.00e-02 505 2 2 1.000 0.004 MI:mmu-miR-743a mi 1 MI:mmu-miR-743a 1 Q9BS40,Q96IY4 353 4.59e-06 35 7 3 0.429 0.086 GO:0019432 BP 1 triglyceride biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 5.01e-06 36 7 3 0.429 0.083 GO:0046460 BP 1 neutral lipid biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 5.01e-06 36 7 3 0.429 0.083 GO:0046463 BP 1 acylglycerol biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 1.98e-05 528 7 5 0.714 0.009 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3 353 2.10e-05 534 7 5 0.714 0.009 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3 353 2.15e-05 58 7 3 0.429 0.052 GO:0006641 BP 1 triglyceride metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 3.81e-05 70 7 3 0.429 0.043 GO:0006638 BP 1 neutral lipid metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 3.81e-05 70 7 3 0.429 0.043 GO:0006639 BP 1 acylglycerol metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 5.87e-05 658 7 5 0.714 0.008 GO:0044432 CC 1 endoplasmic reticulum part 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3 353 2.21e-04 17 7 2 0.286 0.118 GO:0071617 MF 1 lysophospholipid acyltransferase activity 1 Q9NRZ5,Q9NRZ7 353 2.21e-04 17 7 2 0.286 0.118 GO:0042171 MF 1 lysophosphatidic acid acyltransferase activity 1 Q9NRZ5,Q9NRZ7 353 2.21e-04 17 7 2 0.286 0.118 GO:0003841 MF 1 1-acylglycerol-3-phosphate O-acyltransferase activity 1 Q9NRZ5,Q9NRZ7 353 3.06e-04 25 7 2 0.286 0.080 REAC:1483166 rea 1 Synthesis of PA 1 Q9NRZ5,Q9NRZ7 353 3.24e-04 933 7 5 0.714 0.005 GO:0005783 CC 1 endoplasmic reticulum 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3 353 3.75e-04 22 7 2 0.286 0.091 GO:0016411 MF 1 acylglycerol O-acyltransferase activity 1 Q9NRZ5,Q9NRZ7 353 4.38e-04 158 7 3 0.429 0.019 GO:0008654 BP 1 phospholipid biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 4.81e-04 163 7 3 0.429 0.018 GO:0045017 BP 1 glycerolipid biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 4.86e-04 25 7 2 0.286 0.080 GO:0046473 BP 1 phosphatidic acid metabolic process 1 Q9NRZ5,Q9NRZ7 353 4.86e-04 25 7 2 0.286 0.080 GO:0006654 BP 1 phosphatidic acid biosynthetic process 1 Q9NRZ5,Q9NRZ7 353 1.02e-03 36 7 2 0.286 0.056 GO:0008374 MF 1 O-acyltransferase activity 1 Q9NRZ5,Q9NRZ7 353 1.24e-03 1 7 1 0.143 1.000 REAC:190840 rea 1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1 P17302 353 1.49e-03 239 7 3 0.429 0.013 GO:0046486 BP 1 glycerolipid metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 1.51e-03 240 7 3 0.429 0.013 GO:0006644 BP 1 phospholipid metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 2.02e-03 64 7 2 0.286 0.031 REAC:75109 rea 1 Triglyceride Biosynthesis 1 Q9NRZ5,Q9NRZ7 353 2.47e-03 2412 7 6 0.857 0.002 GO:0044425 CC 1 membrane part 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3,P13224 353 2.48e-03 2 7 1 0.143 0.500 REAC:190704 rea 1 Oligomerization of connexins into connexons 1 P17302 353 2.48e-03 2 7 1 0.143 0.500 REAC:190827 rea 1 Transport of connexins along the secretory pathway 1 P17302 353 2.48e-03 2 7 1 0.143 0.500 REAC:190872 rea 1 Transport of connexons to the plasma membrane 1 P17302 353 3.14e-03 1 7 1 0.143 1.000 GO:0086075 MF 1 gap junction channel activity involved in cardiac conduction electrical coupling 1 P17302 353 3.14e-03 1 7 1 0.143 1.000 GO:1903763 MF 1 gap junction channel activity involved in cell communication by electrical coupling 1 P17302 353 3.54e-03 1 7 1 0.143 1.000 TF:M05963_1 tf 1 Factor: ZNF286; motif: KGKTGAGAACGM; match class: 1 1 P13224 353 3.63e-03 1 7 1 0.143 1.000 OMIM:164200 omi 1 Oculodentodigital Syndrome 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:104100 omi 1 PALMOPLANTAR KERATODERMA AND CONGENITAL ALOPECIA 1; PPKCA1;;PPKCA, STEVANOVIC TYPE;;KERATODERMA-HYPOTRICHOSIS-LEUKONYCHIA TOTALIS SYNDROME 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:241550 omi 1 Hypoplastic Left Heart Syndrome 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:218400 omi 1 CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL RECESSIVE; CMDR 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:257850 omi 1 OCULODENTODIGITAL DYSPLASIA, AUTOSOMAL RECESSIVE;;ODDD, AUTOSOMAL RECESSIVE;;OCULODENTOOSSEOUS DYSPLASIA, AUTOSOMAL RECESSIVE;;ODOD, AUTOSOMAL RECESSIVE 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:186100 omi 1 SYNDACTYLY, TYPE III;;SDTY3;;RING AND LITTLE FINGER SYNDACTYLY;;SYNDACTYLY OF FINGERS IV AND V 1 P17302 353 3.63e-03 1 7 1 0.143 1.000 OMIM:600309 omi 1 ATRIOVENTRICULAR SEPTAL DEFECT 3; AVSD3 1 P17302 353 3.72e-03 3 7 1 0.143 0.333 REAC:6806664 rea 1 Metabolism of vitamin K 1 Q8N0U8 353 3.72e-03 3 7 1 0.143 0.333 REAC:191647 rea 1 c-src mediated regulation of Cx43 function and closure of gap junctions 1 P17302 353 3.72e-03 3 7 1 0.143 0.333 REAC:191650 rea 1 Regulation of gap junction activity 1 P17302 353 3.99e-03 334 7 3 0.429 0.009 GO:0090407 BP 1 organophosphate biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 4.68e-03 98 7 2 0.286 0.020 REAC:1483206 rea 1 Glycerophospholipid biosynthesis 1 Q9NRZ5,Q9NRZ7 353 5.25e-03 367 7 3 0.429 0.008 GO:0008610 BP 1 lipid biosynthetic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 6.19e-03 5 7 1 0.143 0.200 REAC:190861 rea 1 Gap junction assembly 1 P17302 353 6.27e-03 2 7 1 0.143 0.500 GO:0005922 CC 1 connexin complex 1 P17302 353 6.27e-03 2 7 1 0.143 0.500 GO:0047057 MF 1 vitamin-K-epoxide reductase (warfarin-sensitive) activity 1 Q8N0U8 353 6.27e-03 2 7 1 0.143 0.500 GO:0016900 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor 1 Q8N0U8 353 6.52e-03 48 7 2 0.286 0.042 KEGG:00561 keg 1 Glycerolipid metabolism 1 Q9NRZ5,Q9NRZ7 353 8.66e-03 7 7 1 0.143 0.143 REAC:75892 rea 1 Platelet Adhesion to exposed collagen 1 P13224 353 8.66e-03 7 7 1 0.143 0.143 REAC:430116 rea 1 GP1b-IX-V activation signalling 1 P13224 353 9.41e-03 3 7 1 0.143 0.333 GO:0035356 BP 1 cellular triglyceride homeostasis 1 Q8N6M3 353 9.41e-03 3 7 1 0.143 0.333 GO:0005243 MF 1 gap junction channel activity 1 P17302 353 1.09e-02 3 7 1 0.143 0.333 OMIM:133200 omi 1 ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA; EKVP;;ERYTHROKERATODERMIA VARIABILIS; EKV;;ERYTHROKERATODERMIA, PROGRESSIVE SYMMETRIC; PSEK;;ERYTHROKERATODERMIA FIGURATA, CONGENITAL FAMILIAL, IN PLAQUES;;ERYTHROKERATODERMIA VARIABILIS WITH ERYTHEMA GYRATUM REPENSGREITHER DISEASE, INCLUDED;;KERATOSIS PALMOPLANTARIS TRANSGREDIENS ET PROGREDIENS, INCLUDED 1 P17302 353 1.09e-02 3 7 1 0.143 0.333 OMIM:606215 omi 1 Isolated Atrioventricular Septal Defect 1 P17302 353 1.11e-02 9 7 1 0.143 0.111 REAC:196025 rea 1 Formation of annular gap junctions 1 P17302 353 1.24e-02 10 7 1 0.143 0.100 REAC:190873 rea 1 Gap junction degradation 1 P17302 353 1.25e-02 4 7 1 0.143 0.250 GO:0022829 MF 1 wide pore channel activity 1 P17302 353 1.25e-02 4 7 1 0.143 0.250 GO:0042373 BP 1 vitamin K metabolic process 1 Q8N0U8 353 1.25e-02 4 7 1 0.143 0.250 GO:0010890 BP 1 positive regulation of sequestering of triglyceride 1 Q8N6M3 353 1.29e-02 165 7 2 0.286 0.012 REAC:1483257 rea 1 Phospholipid metabolism 1 Q9NRZ5,Q9NRZ7 353 1.58e-02 75 7 2 0.286 0.027 KEGG:00564 keg 1 Glycerophospholipid metabolism 1 Q9NRZ5,Q9NRZ7 353 1.61e-02 144 7 2 0.286 0.014 GO:0046474 BP 1 glycerophospholipid biosynthetic process 1 Q9NRZ5,Q9NRZ7 353 1.73e-02 14 7 1 0.143 0.071 REAC:190828 rea 1 Gap junction trafficking 1 P17302 353 1.73e-02 14 7 1 0.143 0.071 REAC:140837 rea 1 Intrinsic Pathway of Fibrin Clot Formation 1 P13224 353 1.88e-02 6 7 1 0.143 0.167 GO:0016264 BP 1 gap junction assembly 1 P17302 353 1.88e-02 6 7 1 0.143 0.167 GO:0018214 BP 1 protein carboxylation 1 Q8N0U8 353 1.88e-02 6 7 1 0.143 0.167 GO:0005921 CC 1 gap junction 1 P17302 353 1.88e-02 6 7 1 0.143 0.167 GO:0010889 BP 1 regulation of sequestering of triglyceride 1 Q8N6M3 353 1.88e-02 6 7 1 0.143 0.167 GO:0017187 BP 1 peptidyl-glutamic acid carboxylation 1 Q8N0U8 353 1.89e-02 201 7 2 0.286 0.010 REAC:535734 rea 1 Fatty acid, triacylglycerol, and ketone body metabolism 1 Q9NRZ5,Q9NRZ7 353 1.91e-02 157 7 2 0.286 0.013 GO:0016747 MF 1 transferase activity, transferring acyl groups other than amino-acyl groups 1 Q9NRZ5,Q9NRZ7 353 1.93e-02 589 7 3 0.429 0.005 TF:M00118_1 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 1 1 P17302,Q8N0U8,P13224 353 1.93e-02 589 7 3 0.429 0.005 TF:M00118_0 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 0 1 P17302,Q8N0U8,P13224 353 1.97e-02 16 7 1 0.143 0.062 REAC:157858 rea 1 Gap junction trafficking and regulation 1 P17302 353 2.03e-02 606 7 3 0.429 0.005 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 2.12e-02 6 7 1 0.143 0.167 TF:M01298_1 tf 1 Factor: MECP2; motif: CCGGSNNNANNAWWT; match class: 1 1 P0CG08 353 2.14e-02 379 7 2 0.286 0.005 MI:mmu-miR-343 mi 1 MI:mmu-miR-343 1 Q9NRZ7,P0CG08 353 2.19e-02 2260 7 5 0.714 0.002 GO:0012505 CC 1 endomembrane system 1 Q9NRZ5,P17302,Q9NRZ7,Q8N0U8,Q8N6M3 353 2.19e-02 7 7 1 0.143 0.143 GO:0086066 BP 1 atrial cardiac muscle cell to AV node cell communication 1 P17302 353 2.19e-02 7 7 1 0.143 0.143 GO:0086014 BP 1 atrial cardiac muscle cell action potential 1 P17302 353 2.19e-02 7 7 1 0.143 0.143 GO:0086026 BP 1 atrial cardiac muscle cell to AV node cell signaling 1 P17302 353 2.39e-02 176 7 2 0.286 0.011 GO:0016746 MF 1 transferase activity, transferring acyl groups 1 Q9NRZ5,Q9NRZ7 353 2.51e-02 8 7 1 0.143 0.125 GO:0034389 BP 1 lipid particle organization 1 Q8N6M3 353 2.51e-02 8 7 1 0.143 0.125 GO:0030730 BP 1 sequestering of triglyceride 1 Q8N6M3 353 2.52e-02 633 7 3 0.429 0.005 GO:0044255 BP 1 cellular lipid metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 2.79e-02 188 7 2 0.286 0.011 TF:M04400_0 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 0 1 P0CG08,Q8N6M3 353 2.80e-02 191 7 2 0.286 0.010 GO:0006650 BP 1 glycerophospholipid metabolic process 1 Q9NRZ5,Q9NRZ7 353 2.83e-02 23 7 1 0.143 0.043 REAC:140877 rea 1 Formation of Fibrin Clot (Clotting Cascade) 1 P13224 353 2.83e-02 8 7 1 0.143 0.125 TF:M05806_0 tf 1 Factor: ZNF529; motif: KGGGTAATAAGA; match class: 0 1 Q8N6M3 353 3.01e-02 674 7 3 0.429 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 3.25e-02 203 7 2 0.286 0.010 TF:M01233_1 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 1 1 P17302,P0CG08 353 3.44e-02 11 7 1 0.143 0.091 GO:0010884 BP 1 positive regulation of lipid storage 1 Q8N6M3 353 3.44e-02 11 7 1 0.143 0.091 GO:0010866 BP 1 regulation of triglyceride biosynthetic process 1 Q8N6M3 353 3.53e-02 1537 7 4 0.571 0.003 TF:M00491_0 tf 1 Factor: MAZR; motif: NSGGGGGGGGMCN; match class: 0 1 P17302,Q9NRZ7,Q8N6M3,P13224 353 3.55e-02 29 7 1 0.143 0.034 REAC:6811436 rea 1 COPI-independent Golgi-to-ER retrograde traffic 1 Q9NRZ7 353 3.55e-02 29 7 1 0.143 0.034 REAC:76009 rea 1 Platelet Aggregation (Plug Formation) 1 P13224 353 3.75e-02 117 7 2 0.286 0.017 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 Q9NRZ5,Q9NRZ7 353 3.75e-02 12 7 1 0.143 0.083 GO:0007597 BP 1 blood coagulation, intrinsic pathway 1 P13224 353 3.77e-02 1565 7 4 0.571 0.003 TF:M00422_1 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 1 1 Q9NRZ5,P17302,Q9NRZ7,Q8N6M3 353 3.94e-02 525 7 2 0.286 0.004 MI:hsa-miR-212 mi 1 MI:hsa-miR-212 1 Q9NRZ7,P0CG08 353 4.00e-02 226 7 2 0.286 0.009 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q9NRZ5,P17302 353 4.02e-02 531 7 2 0.286 0.004 MI:hsa-miR-132 mi 1 MI:hsa-miR-132 1 Q9NRZ7,P0CG08 353 4.07e-02 13 7 1 0.143 0.077 GO:0086019 BP 1 cell-cell signaling involved in cardiac conduction 1 P17302 353 4.07e-02 13 7 1 0.143 0.077 GO:0055090 BP 1 acylglycerol homeostasis 1 Q8N6M3 353 4.07e-02 13 7 1 0.143 0.077 GO:0070328 BP 1 triglyceride homeostasis 1 Q8N6M3 353 4.07e-02 228 7 2 0.286 0.009 TF:M04341_1 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 1 1 Q9NRZ5,P0CG08 353 4.14e-02 230 7 2 0.286 0.009 TF:M04364_0 tf 1 Factor: HOXD13; motif: GCTCGTAAAAN; match class: 0 1 P17302,Q9NRZ7 353 4.30e-02 765 7 3 0.429 0.004 GO:0006629 BP 1 lipid metabolic process 1 Q9NRZ5,Q9NRZ7,Q8N6M3 353 4.47e-02 792 7 3 0.429 0.004 TF:M04359_0 tf 1 Factor: HOXD11; motif: RTCGTAAAAN; match class: 0 1 Q9NRZ5,P17302,Q8N6M3 353 4.69e-02 15 7 1 0.143 0.067 GO:0090207 BP 1 regulation of triglyceride metabolic process 1 Q8N6M3 353 4.94e-02 252 7 2 0.286 0.008 TF:M03883_1 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 1 1 P0CG08,P13224 353 5.00e-02 1 7 1 0.143 1.000 HP:0009772 hp 1 Patchy sclerosis of finger phalanx 1 P17302 353 5.00e-02 14 7 1 0.143 0.071 OMIM:231200 omi 1 Platelet-Type Bleeding Disorders 1 P13224 353 5.00e-02 10 7 1 0.143 0.100 KEGG:00130 keg 1 Ubiquinone and other terpenoid-quinone biosynthesis 1 Q8N0U8 353 5.00e-02 1 7 1 0.143 1.000 HP:0006384 hp 1 Club-shaped distal femur 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0004495 hp 1 Thin anteverted nares 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0012812 hp 1 Fullness of paranasal tissue 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0009162 hp 1 Absent middle phalanx of 5th finger 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0005769 hp 1 Fifth finger distal phalanx clinodactyly 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0008442 hp 1 Vertebral hyperostosis 1 P17302 353 5.00e-02 824 7 3 0.429 0.004 TF:M01253_1 tf 1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 1 1 Q9NRZ7,Q8N0U8,P13224 353 5.00e-02 41 7 1 0.143 0.024 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 Q8N0U8 353 5.00e-02 1 7 1 0.143 1.000 HP:0011560 hp 1 Mitral atresia 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0009238 hp 1 Aplasia of the 5th finger 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0010445 hp 1 Primum atrial septal defect 1 P17302 353 5.00e-02 5 7 1 0.143 0.200 CORUM:2872 cor 1 ITGA2b-ITGB3-CD9-GP1b-CD47 complex 1 P13224 353 5.00e-02 1 7 1 0.143 1.000 HP:0004281 hp 1 Irregular sclerosis of hand bones 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0004286 hp 1 Patchy sclerosis of hand bones 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0006298 hp 1 Prolonged bleeding after dental extraction 1 P13224 353 5.00e-02 1 7 1 0.143 1.000 HP:0011622 hp 1 Inlet ventricular septal defect 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0011546 hp 1 Abnormal atrioventricular connection 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0004407 hp 1 Bony paranasal bossing 1 P17302 353 5.00e-02 16 7 1 0.143 0.062 GO:0086064 BP 1 cell communication by electrical coupling involved in cardiac conduction 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0010705 hp 1 4-5 finger syndactyly 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0005768 hp 1 2-4 toe cutaneous syndactyly 1 P17302 353 5.00e-02 1 7 1 0.143 1.000 HP:0010883 hp 1 Aortic valve atresia 1 P17302 354 2.77e-03 2920 4 4 1.000 0.001 TF:M04609_1 tf 1 Factor: AP-3; motif: TKGAAAKN; match class: 1 1 Q9NZB2,Q02809,P55795,Q14296 354 3.14e-03 10 4 1 0.250 0.100 TF:M06793_0 tf 1 Factor: ZNF629; motif: NKGGGCWAACGC; match class: 0 1 Q14296 354 4.39e-03 351 4 2 0.500 0.006 TF:M07206_0 tf 1 Factor: E2F1; motif: NGGGCGGGARV; match class: 0 1 Q02809,Q14296 354 5.83e-03 1263 4 3 0.750 0.002 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 Q9NZB2,Q02809,P55795 354 6.58e-03 380 4 2 0.500 0.005 MI:hsa-miR-662 mi 1 MI:hsa-miR-662 1 Q02809,Q14296 354 7.21e-03 23 4 1 0.250 0.043 TF:M05990_0 tf 1 Factor: ZNF69; motif: NAMTCGGGATCA; match class: 0 1 P55795 354 7.60e-03 409 4 2 0.500 0.005 MI:mmu-miR-434-5p mi 1 MI:mmu-miR-434-5p 1 Q02809,P55795 354 7.83e-03 25 4 1 0.250 0.040 TF:M06240_0 tf 1 Factor: ZNF616; motif: NGGGTGGAACGM; match class: 0 1 Q14296 354 7.83e-03 25 4 1 0.250 0.040 TF:M05915_0 tf 1 Factor: ZBTB20; motif: NGGTWAAGCSGG; match class: 0 1 Q02809 354 8.36e-03 1 4 1 0.250 1.000 HP:0008458 hp 1 Progressive congenital scoliosis 1 Q02809 354 8.61e-03 436 4 2 0.500 0.005 MI:hsa-miR-657 mi 1 MI:hsa-miR-657 1 Q9NZB2,Q14296 354 8.65e-03 1706 4 3 0.750 0.002 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 Q9NZB2,P55795,Q14296 354 8.74e-03 1712 4 3 0.750 0.002 TF:M01888_1 tf 1 Factor: Smad3; motif: NGNCAGACASNNN; match class: 1 1 Q02809,P55795,Q14296 354 9.53e-03 1764 4 3 0.750 0.002 TF:M01592_0 tf 1 Factor: LBP9; motif: CCRGNNNNARCCRGYYN; match class: 0 1 Q02809,P55795,Q14296 354 1.15e-02 507 4 2 0.500 0.004 MI:hsa-miR-454 mi 1 MI:hsa-miR-454 1 P55795,Q14296 354 1.19e-02 514 4 2 0.500 0.004 MI:hsa-miR-199a-5p mi 1 MI:hsa-miR-199a-5p 1 Q02809,P55795 354 1.20e-02 588 4 2 0.500 0.003 TF:M01252_1 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 1 1 P55795,Q14296 354 1.22e-02 521 4 2 0.500 0.004 MI:mmu-miR-883b-3p mi 1 MI:mmu-miR-883b-3p 1 Q9NZB2,P55795 354 1.23e-02 595 4 2 0.500 0.003 TF:M00483_1 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 1 1 Q9NZB2,Q14296 354 1.23e-02 524 4 2 0.500 0.004 MI:mmu-miR-467d mi 1 MI:mmu-miR-467d 1 Q9NZB2,Q14296 354 1.26e-02 531 4 2 0.500 0.004 MI:mmu-miR-467c mi 1 MI:mmu-miR-467c 1 Q9NZB2,Q14296 354 1.43e-02 2032 4 3 0.750 0.001 TF:M07375_0 tf 1 Factor: BCL-6; motif: TTCCTAGAAA; match class: 0 1 Q9NZB2,P55795,Q14296 354 1.44e-02 46 4 1 0.250 0.022 TF:M06889_0 tf 1 Factor: znf658b; motif: NTGGNGAAGAGC; match class: 0 1 Q9NZB2 354 1.44e-02 46 4 1 0.250 0.022 TF:M06890_0 tf 1 Factor: ZNF658; motif: NTGGNGAAGAGC; match class: 0 1 Q9NZB2 354 1.47e-02 47 4 1 0.250 0.021 TF:M06259_0 tf 1 Factor: ZNF91; motif: NATGGCGGCCGC; match class: 0 1 Q9NZB2 354 1.50e-02 48 4 1 0.250 0.021 TF:M05921_0 tf 1 Factor: ZFP14; motif: KGGTGAAAAATA; match class: 0 1 P55795 354 1.57e-02 2098 4 3 0.750 0.001 TF:M01288_0 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 0 1 Q9NZB2,Q02809,Q14296 354 1.67e-02 1 4 1 0.250 1.000 GO:0046946 BP 1 hydroxylysine metabolic process 1 Q02809 354 1.67e-02 1 4 1 0.250 1.000 GO:0046947 BP 1 hydroxylysine biosynthetic process 1 Q02809 354 1.67e-02 2 4 1 0.250 0.500 HP:0005952 hp 1 Decreased pulmonary function 1 Q02809 354 1.89e-02 4006 4 4 1.000 0.001 HPA:029010_02 hpa 1 placenta; decidual cells[Uncertain,Medium] 1 Q9NZB2,Q02809,P55795,Q14296 354 1.94e-02 753 4 2 0.500 0.003 TF:M00796_1 tf 1 Factor: USF; motif: NRCCACGTGASN; match class: 1 1 P55795,Q14296 354 2.01e-02 1941 4 3 0.750 0.002 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 Q9NZB2,Q02809,P55795 354 2.12e-02 68 4 1 0.250 0.015 TF:M05617_0 tf 1 Factor: ZNF500; motif: NGTTCCGGGGRW; match class: 0 1 Q14296 354 2.21e-02 2367 4 3 0.750 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q9NZB2,P55795,Q14296 354 2.66e-02 889 4 2 0.500 0.002 TF:M04044_0 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 0 1 P55795,Q14296 354 2.74e-02 88 4 1 0.250 0.011 TF:M01116_1 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 1 1 Q14296 354 2.76e-02 2561 4 3 0.750 0.001 TF:M04154_1 tf 1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 1 1 Q9NZB2,P55795,Q14296 354 2.81e-02 2576 4 3 0.750 0.001 TF:M04616_0 tf 1 Factor: islet1; motif: NGNTAATG; match class: 0 1 Q02809,P55795,Q14296 354 2.86e-02 92 4 1 0.250 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 P55795 354 3.03e-02 953 4 2 0.500 0.002 TF:M04193_1 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 1 1 P55795,Q14296 354 3.06e-02 56 4 1 0.250 0.018 REAC:1650814 rea 1 Collagen biosynthesis and modifying enzymes 1 Q02809 354 3.12e-02 2673 4 3 0.750 0.001 TF:M01047_1 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 1 Q9NZB2,P55795,Q14296 354 3.12e-02 2673 4 3 0.750 0.001 TF:M01047_0 tf 1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 0 1 Q9NZB2,P55795,Q14296 354 3.23e-02 2705 4 3 0.750 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q9NZB2,P55795,Q14296 354 3.23e-02 985 4 2 0.500 0.002 TF:M03907_0 tf 1 Factor: HINFP; motif: CNRCGTCCGCNN; match class: 0 1 Q9NZB2,Q14296 354 3.26e-02 5411 4 4 1.000 0.001 TF:M01888_0 tf 1 Factor: Smad3; motif: NGNCAGACASNNN; match class: 0 1 Q9NZB2,Q02809,P55795,Q14296 354 3.34e-02 4 4 1 0.250 0.250 HP:0007605 hp 1 Excessive wrinkling of palmar skin 1 Q02809 354 3.34e-02 4 4 1 0.250 0.250 HP:0007517 hp 1 Palmoplantar cutis laxa 1 Q02809 354 3.40e-02 5466 4 4 1.000 0.001 TF:M00470_1 tf 1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 1 Q9NZB2,Q02809,P55795,Q14296 354 3.47e-02 867 4 2 0.500 0.002 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 Q9NZB2,P55795 354 3.47e-02 867 4 2 0.500 0.002 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q9NZB2,P55795 354 3.47e-02 112 4 1 0.250 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 P55795 354 4.14e-02 76 4 1 0.250 0.013 REAC:1474290 rea 1 Collagen formation 1 Q02809 354 4.17e-02 5 4 1 0.250 0.200 HP:0007392 hp 1 Excessive wrinkled skin 1 Q02809 354 4.30e-02 139 4 1 0.250 0.007 TF:M05321_0 tf 1 Factor: TBR2; motif: TTNACACCTR; match class: 0 1 Q14296 354 4.30e-02 139 4 1 0.250 0.007 TF:M05366_0 tf 1 Factor: Tbr-1; motif: TTNACACCTR; match class: 0 1 Q14296 354 4.30e-02 139 4 1 0.250 0.007 TF:M05495_0 tf 1 Factor: T-bet; motif: TTAACACCTA; match class: 0 1 Q14296 354 4.31e-02 3000 4 3 0.750 0.001 TF:M04238_0 tf 1 Factor: FOXD2; motif: NRNWAATATTTAYN; match class: 0 1 Q9NZB2,Q02809,P55795 354 4.38e-02 3018 4 3 0.750 0.001 TF:M01863_0 tf 1 Factor: ATF-3; motif: RTKRCGTCANN; match class: 0 1 Q9NZB2,P55795,Q14296 354 4.58e-02 3066 4 3 0.750 0.001 TF:M02273_0 tf 1 Factor: NURR1; motif: AAGGTCAC; match class: 0 1 Q9NZB2,P55795,Q14296 354 4.69e-02 3093 4 3 0.750 0.001 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 Q9NZB2,P55795,Q14296 354 4.72e-02 153 4 1 0.250 0.007 TF:M05731_0 tf 1 Factor: ZNF660; motif: NGGGGGGAACSM; match class: 0 1 Q14296 354 4.87e-02 158 4 1 0.250 0.006 TF:M06398_0 tf 1 Factor: ZNF761; motif: GGKWAATCAGA; match class: 0 1 Q9NZB2 354 4.96e-02 3156 4 3 0.750 0.001 TF:M07041_1 tf 1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 1 Q9NZB2,Q02809,Q14296 354 5.00e-02 6 4 1 0.250 0.167 HP:0000993 hp 1 Molluscoid pseudotumors 1 Q02809 354 5.00e-02 6 4 1 0.250 0.167 HP:0005294 hp 1 Arterial dissection 1 Q02809 354 5.00e-02 1 4 1 0.250 1.000 OMIM:225400 omi 1 EHLERS-DANLOS SYNDROME, TYPE VI; EDS6;;EHLERS-DANLOS SYNDROME, KYPHOSCOLIOTIC TYPE;;EDS VI;;EHLERS-DANLOS SYNDROME, OCULAR-SCOLIOTIC TYPE;;NEVO SYNDROME;;EHLERS-DANLOS SYNDROME, TYPE VIA, FORMERLY; EDS6A, FORMERLY 1 Q02809 354 5.00e-02 55 4 1 0.250 0.018 KEGG:00310 keg 1 Lysine degradation 1 Q02809 354 5.00e-02 3 4 1 0.250 0.333 GO:0008475 MF 1 procollagen-lysine 5-dioxygenase activity 1 Q02809 355 6.32e-09 17 3 3 1.000 0.176 GO:0005852 CC 1 eukaryotic translation initiation factor 3 complex 1 Q13347,O15371,P55884 355 6.08e-08 35 3 3 1.000 0.086 GO:0003743 MF 1 translation initiation factor activity 1 Q13347,O15371,P55884 355 4.87e-07 69 3 3 1.000 0.043 GO:0008135 MF 1 translation factor activity, RNA binding 1 Q13347,O15371,P55884 355 1.07e-06 5 3 2 0.667 0.400 GO:0075525 BP 1 viral translational termination-reinitiation 1 O15371,P55884 355 2.03e-06 52 3 3 1.000 0.058 REAC:72695 rea 1 Formation of the ternary complex, and subsequently, the 43S complex 1 Q13347,O15371,P55884 355 2.25e-06 7 3 2 0.667 0.286 GO:0075522 BP 1 IRES-dependent viral translational initiation 1 O15371,P55884 355 2.98e-06 59 3 3 1.000 0.051 REAC:72649 rea 1 Translation initiation complex formation 1 Q13347,O15371,P55884 355 2.98e-06 59 3 3 1.000 0.051 REAC:72702 rea 1 Ribosomal scanning and start codon recognition 1 Q13347,O15371,P55884 355 3.14e-06 60 3 3 1.000 0.050 REAC:72662 rea 1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1 Q13347,O15371,P55884 355 4.82e-06 10 3 2 0.667 0.200 GO:0019081 BP 1 viral translation 1 O15371,P55884 355 5.89e-06 11 3 2 0.667 0.182 GO:0002192 BP 1 IRES-dependent translational initiation 1 O15371,P55884 355 6.71e-06 164 3 3 1.000 0.018 GO:0006413 BP 1 translational initiation 1 Q13347,O15371,P55884 355 9.75e-06 14 3 2 0.667 0.143 GO:0002190 BP 1 cap-independent translational initiation 1 O15371,P55884 355 1.29e-05 16 3 2 0.667 0.125 GO:0002183 BP 1 cytoplasmic translational initiation 1 O15371,P55884 355 1.48e-05 100 3 3 1.000 0.030 REAC:72689 rea 1 Formation of a pool of free 40S subunits 1 Q13347,O15371,P55884 355 1.98e-05 110 3 3 1.000 0.027 REAC:156827 rea 1 L13a-mediated translational silencing of Ceruloplasmin expression 1 Q13347,O15371,P55884 355 2.04e-05 111 3 3 1.000 0.027 REAC:72706 rea 1 GTP hydrolysis and joining of the 60S ribosomal subunit 1 Q13347,O15371,P55884 355 2.45e-05 118 3 3 1.000 0.025 REAC:72737 rea 1 Cap-dependent Translation Initiation 1 Q13347,O15371,P55884 355 2.45e-05 118 3 3 1.000 0.025 REAC:72613 rea 1 Eukaryotic Translation Initiation 1 Q13347,O15371,P55884 355 5.59e-05 155 3 3 1.000 0.019 REAC:72766 rea 1 Translation 1 Q13347,O15371,P55884 355 1.26e-04 49 3 2 0.667 0.041 GO:0002181 BP 1 cytoplasmic translation 1 O15371,P55884 355 1.73e-04 483 3 3 1.000 0.006 GO:0006412 BP 1 translation 1 Q13347,O15371,P55884 355 1.90e-04 498 3 3 1.000 0.006 GO:0043043 BP 1 peptide biosynthetic process 1 Q13347,O15371,P55884 355 2.55e-04 549 3 3 1.000 0.005 GO:0043604 BP 1 amide biosynthetic process 1 Q13347,O15371,P55884 355 3.20e-04 592 3 3 1.000 0.005 GO:0006518 BP 1 peptide metabolic process 1 Q13347,O15371,P55884 355 4.79e-04 12 3 3 1.000 0.250 CORUM:742 cor 1 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) 1 Q13347,O15371,P55884 355 5.43e-04 706 3 3 1.000 0.004 GO:0043603 BP 1 cellular amide metabolic process 1 Q13347,O15371,P55884 355 6.18e-04 1 3 1 0.333 1.000 GO:0098808 MF 1 mRNA cap binding 1 O15371 355 6.23e-04 13 3 3 1.000 0.231 CORUM:1097 cor 1 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) 1 Q13347,O15371,P55884 355 1.24e-03 2 3 1 0.333 0.500 GO:0002191 BP 1 cap-dependent translational initiation 1 O15371 355 1.39e-03 965 3 3 1.000 0.003 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q13347,O15371,P55884 355 1.62e-03 175 3 2 0.667 0.011 GO:0019080 BP 1 viral gene expression 1 O15371,P55884 355 1.96e-03 193 3 2 0.667 0.010 GO:0044033 BP 1 multi-organism metabolic process 1 O15371,P55884 355 3.69e-03 1336 3 3 1.000 0.002 GO:0003723 MF 1 RNA binding 1 Q13347,O15371,P55884 355 5.93e-03 1565 3 3 1.000 0.002 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q13347,O15371,P55884 355 6.09e-03 341 3 2 0.667 0.006 GO:0019058 BP 1 viral life cycle 1 O15371,P55884 355 7.28e-03 373 3 2 0.667 0.005 GO:0016032 BP 1 viral process 1 O15371,P55884 355 7.35e-03 375 3 2 0.667 0.005 GO:0044764 BP 1 multi-organism cellular process 1 O15371,P55884 355 7.79e-03 386 3 2 0.667 0.005 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 O15371,P55884 355 7.79e-03 386 3 2 0.667 0.005 GO:0044419 BP 1 interspecies interaction between organisms 1 O15371,P55884 355 8.03e-03 13 3 1 0.333 0.077 GO:0000339 MF 1 RNA cap binding 1 O15371 355 9.65e-03 625 3 2 0.667 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q13347,P55884 355 1.25e-02 713 3 2 0.667 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q13347,P55884 355 1.32e-02 733 3 2 0.667 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q13347,P55884 355 1.42e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 Q13347,O15371,P55884 355 1.50e-02 3 3 2 0.667 0.667 CORUM:4395 cor 1 EIF3 complex (EIF3B, EIF3G, EIF3I) 1 Q13347,P55884 355 1.50e-02 3 3 2 0.667 0.667 CORUM:4399 cor 1 EIF3 complex (EIF3B, EIF3J, EIF3I) 1 Q13347,P55884 355 1.51e-02 2136 3 3 1.000 0.001 GO:0003676 MF 1 nucleic acid binding 1 Q13347,O15371,P55884 355 1.77e-02 2815 3 3 1.000 0.001 HPA:041020_02 hpa 1 spleen; cells in white pulp[Uncertain,Medium] 1 Q13347,O15371,P55884 355 2.05e-02 919 3 2 0.667 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q13347,P55884 355 2.13e-02 938 3 2 0.667 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q13347,P55884 355 2.18e-02 650 3 2 0.667 0.003 GO:0051704 BP 1 multi-organism process 1 O15371,P55884 355 2.39e-02 994 3 2 0.667 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 Q13347,P55884 355 2.44e-02 1169 3 3 1.000 0.003 REAC:392499 rea 1 Metabolism of proteins 1 Q13347,O15371,P55884 355 2.76e-02 2612 3 3 1.000 0.001 GO:1901363 MF 1 heterocyclic compound binding 1 Q13347,O15371,P55884 355 2.82e-02 333 3 2 0.667 0.006 MI:hsa-miR-106a* mi 1 MI:hsa-miR-106a* 1 Q13347,P55884 355 2.84e-02 3293 3 3 1.000 0.001 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 Q13347,O15371,P55884 355 2.90e-02 1100 3 2 0.667 0.002 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 Q13347,P55884 355 2.91e-02 2660 3 3 1.000 0.001 GO:0097159 MF 1 organic cyclic compound binding 1 Q13347,O15371,P55884 355 2.94e-02 1107 3 2 0.667 0.002 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q13347,P55884 355 3.00e-02 4 3 2 0.667 0.500 CORUM:4389 cor 1 EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I) 1 Q13347,P55884 355 3.01e-02 1121 3 2 0.667 0.002 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 Q13347,P55884 355 3.05e-02 1129 3 2 0.667 0.002 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q13347,P55884 355 3.07e-02 2707 3 3 1.000 0.001 GO:0005829 CC 1 cytosol 1 Q13347,O15371,P55884 355 3.07e-02 2707 3 3 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q13347,O15371,P55884 355 3.07e-02 1133 3 2 0.667 0.002 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q13347,P55884 355 3.08e-02 50 3 1 0.333 0.020 GO:0032947 MF 1 protein complex scaffold 1 P55884 355 3.29e-02 2770 3 3 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q13347,O15371,P55884 355 3.33e-02 121 3 1 0.333 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 P55884 355 3.45e-02 56 3 1 0.333 0.018 GO:0006446 BP 1 regulation of translational initiation 1 P55884 355 3.47e-02 3521 3 3 1.000 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q13347,O15371,P55884 355 3.55e-02 1221 3 2 0.667 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q13347,P55884 355 3.58e-02 3559 3 3 1.000 0.001 HPA:035010_02 hpa 1 skin 1; Langerhans[Uncertain,Medium] 1 Q13347,O15371,P55884 355 3.65e-02 2869 3 3 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q13347,O15371,P55884 355 3.66e-02 1242 3 2 0.667 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 Q13347,P55884 355 3.69e-02 1247 3 2 0.667 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q13347,P55884 355 4.05e-02 1308 3 2 0.667 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 Q13347,P55884 355 4.10e-02 1317 3 2 0.667 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 Q13347,P55884 355 4.14e-02 2990 3 3 1.000 0.001 GO:0044267 BP 1 cellular protein metabolic process 1 Q13347,O15371,P55884 355 4.17e-02 1329 3 2 0.667 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 Q13347,P55884 355 4.22e-02 1337 3 2 0.667 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q13347,P55884 355 4.36e-02 1360 3 2 0.667 0.001 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q13347,P55884 355 4.43e-02 3058 3 3 1.000 0.001 GO:0010467 BP 1 gene expression 1 Q13347,O15371,P55884 355 4.43e-02 1372 3 2 0.667 0.001 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q13347,P55884 355 4.58e-02 1396 3 2 0.667 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q13347,P55884 355 4.63e-02 1403 3 2 0.667 0.001 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q13347,P55884 355 4.66e-02 1408 3 2 0.667 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q13347,P55884 355 4.73e-02 1419 3 2 0.667 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q13347,P55884 355 4.74e-02 433 3 2 0.667 0.005 MI:hsa-miR-423-3p mi 1 MI:hsa-miR-423-3p 1 Q13347,O15371 355 4.74e-02 3907 3 3 1.000 0.001 HPA:012010_01 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Low] 1 Q13347,O15371,P55884 355 4.86e-02 3939 3 3 1.000 0.001 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 Q13347,O15371,P55884 355 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q13347,P55884 355 5.00e-02 445 3 2 0.667 0.004 MI:hsa-miR-499-3p mi 1 MI:hsa-miR-499-3p 1 O15371,P55884 355 5.00e-02 3185 3 3 1.000 0.001 GO:0019538 BP 1 protein metabolic process 1 Q13347,O15371,P55884 355 5.00e-02 147 3 2 0.667 0.014 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 Q13347,O15371 355 5.00e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 Q13347,O15371,P55884 355 5.00e-02 152 3 3 1.000 0.020 KEGG:03013 keg 1 RNA transport 1 Q13347,O15371,P55884 356 2.98e-09 15 3 3 1.000 0.200 GO:0005859 CC 1 muscle myosin complex 1 P12883,P11055,Q9Y623 356 5.34e-09 18 3 3 1.000 0.167 GO:0000146 MF 1 microfilament motor activity 1 P12883,P11055,Q9Y623 356 7.46e-09 20 3 3 1.000 0.150 GO:0016460 CC 1 myosin II complex 1 P12883,P11055,Q9Y623 356 2.14e-08 28 3 3 1.000 0.107 GO:0016459 CC 1 myosin complex 1 P12883,P11055,Q9Y623 356 2.94e-08 31 3 3 1.000 0.097 GO:0033275 BP 1 actin-myosin filament sliding 1 P12883,P11055,Q9Y623 356 2.94e-08 31 3 3 1.000 0.097 GO:0030049 BP 1 muscle filament sliding 1 P12883,P11055,Q9Y623 356 2.36e-07 61 3 3 1.000 0.049 GO:0070252 BP 1 actin-mediated cell contraction 1 P12883,P11055,Q9Y623 356 4.65e-07 57 3 3 1.000 0.053 REAC:1445148 rea 1 Translocation of GLUT4 to the plasma membrane 1 P12883,P11055,Q9Y623 356 4.79e-07 77 3 3 1.000 0.039 GO:0030048 BP 1 actin filament-based movement 1 P12883,P11055,Q9Y623 356 6.01e-07 83 3 3 1.000 0.036 GO:0030017 CC 1 sarcomere 1 P12883,P11055,Q9Y623 356 6.70e-07 86 3 3 1.000 0.035 GO:0003774 MF 1 motor activity 1 P12883,P11055,Q9Y623 356 8.77e-07 94 3 3 1.000 0.032 GO:0030016 CC 1 myofibril 1 P12883,P11055,Q9Y623 356 9.06e-07 95 3 3 1.000 0.032 GO:0044449 CC 1 contractile fiber part 1 P12883,P11055,Q9Y623 356 1.09e-06 101 3 3 1.000 0.030 GO:0043292 CC 1 contractile fiber 1 P12883,P11055,Q9Y623 356 4.72e-06 164 3 3 1.000 0.018 GO:0006936 BP 1 muscle contraction 1 P12883,P11055,Q9Y623 356 6.05e-06 178 3 3 1.000 0.017 GO:0046034 BP 1 ATP metabolic process 1 P12883,P11055,Q9Y623 356 7.25e-06 189 3 3 1.000 0.016 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P12883,P11055,Q9Y623 356 7.37e-06 190 3 3 1.000 0.016 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P12883,P11055,Q9Y623 356 7.37e-06 190 3 3 1.000 0.016 GO:0003012 BP 1 muscle system process 1 P12883,P11055,Q9Y623 356 7.72e-06 193 3 3 1.000 0.016 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P12883,P11055,Q9Y623 356 8.73e-06 201 3 3 1.000 0.015 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P12883,P11055,Q9Y623 356 8.73e-06 201 3 3 1.000 0.015 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P12883,P11055,Q9Y623 356 8.99e-06 203 3 3 1.000 0.015 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P12883,P11055,Q9Y623 356 9.40e-06 206 3 3 1.000 0.015 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P12883,P11055,Q9Y623 356 9.96e-06 210 3 3 1.000 0.014 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P12883,P11055,Q9Y623 356 1.29e-05 19 3 2 0.667 0.105 GO:0003009 BP 1 skeletal muscle contraction 1 P12883,P11055 356 1.44e-05 111 3 3 1.000 0.027 KEGG:04530 keg 1 Tight junction 1 P12883,P11055,Q9Y623 356 1.49e-05 240 3 3 1.000 0.013 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P12883,P11055,Q9Y623 356 1.55e-05 243 3 3 1.000 0.012 GO:0042278 BP 1 purine nucleoside metabolic process 1 P12883,P11055,Q9Y623 356 1.58e-05 21 3 2 0.667 0.095 GO:0050881 BP 1 musculoskeletal movement 1 P12883,P11055 356 1.58e-05 21 3 2 0.667 0.095 GO:0050879 BP 1 multicellular organismal movement 1 P12883,P11055 356 1.70e-05 251 3 3 1.000 0.012 GO:0009119 BP 1 ribonucleoside metabolic process 1 P12883,P11055,Q9Y623 356 2.39e-05 281 3 3 1.000 0.011 GO:0009116 BP 1 nucleoside metabolic process 1 P12883,P11055,Q9Y623 356 2.89e-05 299 3 3 1.000 0.010 GO:1901657 BP 1 glycosyl compound metabolic process 1 P12883,P11055,Q9Y623 356 3.00e-05 303 3 3 1.000 0.010 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P12883,P11055,Q9Y623 356 3.10e-05 306 3 3 1.000 0.010 GO:0015629 CC 1 actin cytoskeleton 1 P12883,P11055,Q9Y623 356 3.13e-05 307 3 3 1.000 0.010 GO:0009259 BP 1 ribonucleotide metabolic process 1 P12883,P11055,Q9Y623 356 3.51e-05 319 3 3 1.000 0.009 GO:0019693 BP 1 ribose phosphate metabolic process 1 P12883,P11055,Q9Y623 356 3.68e-05 324 3 3 1.000 0.009 GO:0006163 BP 1 purine nucleotide metabolic process 1 P12883,P11055,Q9Y623 356 4.64e-05 350 3 3 1.000 0.009 GO:0072521 BP 1 purine-containing compound metabolic process 1 P12883,P11055,Q9Y623 356 4.80e-05 354 3 3 1.000 0.008 GO:0016887 MF 1 ATPase activity 1 P12883,P11055,Q9Y623 356 6.32e-05 388 3 3 1.000 0.008 GO:0009117 BP 1 nucleotide metabolic process 1 P12883,P11055,Q9Y623 356 6.83e-05 398 3 3 1.000 0.008 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P12883,P11055,Q9Y623 356 7.97e-05 419 3 3 1.000 0.007 GO:0030029 BP 1 actin filament-based process 1 P12883,P11055,Q9Y623 356 9.88e-05 450 3 3 1.000 0.007 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P12883,P11055,Q9Y623 356 1.83e-04 553 3 3 1.000 0.005 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P12883,P11055,Q9Y623 356 2.09e-04 75 3 2 0.667 0.027 GO:0006941 BP 1 striated muscle contraction 1 P12883,P11055 356 2.23e-04 590 3 3 1.000 0.005 GO:0016462 MF 1 pyrophosphatase activity 1 P12883,P11055,Q9Y623 356 2.25e-04 592 3 3 1.000 0.005 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P12883,P11055,Q9Y623 356 2.25e-04 592 3 3 1.000 0.005 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P12883,P11055,Q9Y623 356 3.33e-04 674 3 3 1.000 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 P12883,P11055,Q9Y623 356 3.62e-04 693 3 3 1.000 0.004 GO:0003008 BP 1 system process 1 P12883,P11055,Q9Y623 356 3.75e-04 522 3 3 1.000 0.006 REAC:199991 rea 1 Membrane Trafficking 1 P12883,P11055,Q9Y623 356 4.35e-04 1 3 1 0.333 1.000 GO:0031444 BP 1 slow-twitch skeletal muscle fiber contraction 1 P12883 356 4.35e-04 1 3 1 0.333 1.000 GO:0031449 BP 1 regulation of slow-twitch skeletal muscle fiber contraction 1 P12883 356 4.36e-04 549 3 3 1.000 0.005 REAC:5653656 rea 1 Vesicle-mediated transport 1 P12883,P11055,Q9Y623 356 5.52e-04 798 3 3 1.000 0.004 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P12883,P11055,Q9Y623 356 5.72e-04 124 3 2 0.667 0.016 GO:0007517 BP 1 muscle organ development 1 P12883,P11055 356 8.71e-04 2 3 1 0.333 0.500 GO:0014862 BP 1 regulation of skeletal muscle contraction by chemo-mechanical energy conversion 1 P12883 356 8.71e-04 2 3 1 0.333 0.500 GO:0003010 BP 1 voluntary skeletal muscle contraction 1 P12883 356 8.71e-04 2 3 1 0.333 0.500 GO:0014728 BP 1 regulation of the force of skeletal muscle contraction 1 P12883 356 8.71e-04 2 3 1 0.333 0.500 GO:0014721 BP 1 twitch skeletal muscle contraction 1 P12883 356 8.71e-04 2 3 1 0.333 0.500 GO:0014724 BP 1 regulation of twitch skeletal muscle contraction 1 P12883 356 8.83e-04 933 3 3 1.000 0.003 GO:0044430 CC 1 cytoskeletal part 1 P12883,P11055,Q9Y623 356 1.14e-03 1016 3 3 1.000 0.003 GO:0006928 BP 1 movement of cell or subcellular component 1 P12883,P11055,Q9Y623 356 1.74e-03 4 3 1 0.333 0.250 GO:0017018 MF 1 myosin phosphatase activity 1 P11055 356 1.74e-03 4 3 1 0.333 0.250 GO:0007512 BP 1 adult heart development 1 P12883 356 1.75e-03 217 3 2 0.667 0.009 GO:0061061 BP 1 muscle structure development 1 P12883,P11055 356 1.90e-03 1204 3 3 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 P12883,P11055,Q9Y623 356 2.58e-03 1333 3 3 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P12883,P11055,Q9Y623 356 2.58e-03 264 3 2 0.667 0.008 GO:0042623 MF 1 ATPase activity, coupled 1 P12883,P11055 356 2.76e-03 1307 3 3 1.000 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 P12883,P11055,Q9Y623 356 2.80e-03 1 3 1 0.333 1.000 OMIM:193700 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 2A; DA2A;;FREEMAN-SHELDON SYNDROME; FSS;;WHISTLING FACE-WINDMILL VANE HAND SYNDROME;;CRANIOCARPOTARSAL DYSTROPHY;;CRANIOCARPOTARSAL DYSPLASIA 1 P11055 356 2.80e-03 1 3 1 0.333 1.000 OMIM:608358 omi 1 MYOPATHY, MYOSIN STORAGE, AUTOSOMAL DOMINANT; MSMA;;MYOPATHY, HYALINE BODY, AUTOSOMAL DOMINANT;;MYOPATHY WITH LYSIS OF TYPE I MYOFIBRILS 1 P12883 356 2.80e-03 1 3 1 0.333 1.000 OMIM:181430 omi 1 SCAPULOPERONEAL MYOPATHY, MYH7-RELATED; SPMM;;SCAPULOPERONEAL MUSCULAR DYSTROPHY; SPMD;;SCAPULOPERONEAL SYNDROME, MYOPATHIC TYPE 1 P12883 356 2.80e-03 1 3 1 0.333 1.000 OMIM:255160 omi 1 MYOPATHY, MYOSIN STORAGE, AUTOSOMAL RECESSIVE; MSMB;;MYOPATHY, HYALINE BODY, AUTOSOMAL RECESSIVE 1 P12883 356 2.80e-03 1 3 1 0.333 1.000 OMIM:160500 omi 1 MYOPATHY, DISTAL, 1; MPD1;;MYOPATHY, LATE DISTAL HEREDITARY;;LAING DISTAL MYOPATHY;;MYOPATHY, DISTAL, EARLY-ONSET, AUTOSOMAL DOMINANT 1 P12883 356 2.80e-03 1 3 1 0.333 1.000 OMIM:178110 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 8; DA8;;MULTIPLE PTERYGIUM SYNDROME, AUTOSOMAL DOMINANT;;PTERYGIUM SYNDROME, MULTIPLE, AUTOSOMAL DOMINANT 1 P11055 356 2.80e-03 1 3 1 0.333 1.000 OMIM:613426 omi 1 CARDIOMYOPATHY, DILATED, 1S; CMD1SLEFT VENTRICULAR NONCOMPACTION 5, INCLUDED; LVNC5, INCLUDED 1 P12883 356 3.05e-03 7 3 1 0.333 0.143 GO:0032982 CC 1 myosin filament 1 P12883 356 3.48e-03 8 3 1 0.333 0.125 GO:0014819 BP 1 regulation of skeletal muscle contraction 1 P12883 356 3.92e-03 9 3 1 0.333 0.111 GO:0030898 MF 1 actin-dependent ATPase activity 1 P12883 356 4.01e-03 1480 3 3 1.000 0.002 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P12883,P11055,Q9Y623 356 4.17e-03 1565 3 3 1.000 0.002 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P12883,P11055,Q9Y623 356 4.52e-03 1607 3 3 1.000 0.002 GO:0016787 MF 1 hydrolase activity 1 P12883,P11055,Q9Y623 356 5.22e-03 12 3 1 0.333 0.083 GO:0060325 BP 1 face morphogenesis 1 P11055 356 5.22e-03 12 3 1 0.333 0.083 GO:0002026 BP 1 regulation of the force of heart contraction 1 P12883 356 5.65e-03 13 3 1 0.333 0.077 GO:0060323 BP 1 head morphogenesis 1 P11055 356 5.65e-03 13 3 1 0.333 0.077 GO:0045214 BP 1 sarcomere organization 1 P11055 356 5.73e-03 565 3 2 0.667 0.004 TF:M02261_1 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 1 1 P12883,P11055 356 6.22e-03 589 3 2 0.667 0.003 TF:M00118_0 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 0 1 P11055,Q9Y623 356 6.22e-03 589 3 2 0.667 0.003 TF:M00118_1 tf 1 Factor: c-Myc:Max; motif: NNACCACGTGGTNN; match class: 1 1 P11055,Q9Y623 356 6.52e-03 15 3 1 0.333 0.067 GO:0060324 BP 1 face development 1 P11055 356 6.55e-03 605 3 2 0.667 0.003 TF:M01967_0 tf 1 Factor: Pbx; motif: NKTGATTGACRKSN; match class: 0 1 P12883,Q9Y623 356 6.59e-03 28 3 1 0.333 0.036 TF:M06846_1 tf 1 Factor: ZFHX2; motif: WGWGGTCCCCC; match class: 1 1 P11055 356 6.91e-03 1851 3 3 1.000 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P12883,P11055,Q9Y623 356 7.75e-03 1923 3 3 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 P12883,P11055,Q9Y623 356 8.20e-03 1960 3 3 1.000 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P12883,P11055,Q9Y623 356 8.20e-03 1960 3 3 1.000 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P12883,P11055,Q9Y623 356 8.38e-03 3 3 1 0.333 0.333 OMIM:601680 omi 1 ARTHROGRYPOSIS, DISTAL, TYPE 2B; DA2B;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE 2B;;SHELDON-HALL SYNDROME; SHS;;FREEMAN-SHELDON SYNDROME VARIANT; FSSV;;ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE II, WITH CRANIOFACIALABNORMALITIES 1 P11055 356 9.13e-03 21 3 1 0.333 0.048 GO:0010171 BP 1 body morphogenesis 1 P11055 356 1.00e-02 2096 3 3 1.000 0.001 GO:0043234 CC 1 protein complex 1 P12883,P11055,Q9Y623 356 1.03e-02 2026 3 3 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P12883,P11055,Q9Y623 356 1.08e-02 26 3 1 0.333 0.038 REAC:390522 rea 1 Striated Muscle Contraction 1 P11055 356 1.09e-02 25 3 1 0.333 0.040 GO:0035113 BP 1 embryonic appendage morphogenesis 1 P11055 356 1.09e-02 25 3 1 0.333 0.040 GO:0055010 BP 1 ventricular cardiac muscle tissue morphogenesis 1 P12883 356 1.09e-02 25 3 1 0.333 0.040 GO:0030326 BP 1 embryonic limb morphogenesis 1 P11055 356 1.13e-02 26 3 1 0.333 0.038 GO:0003229 BP 1 ventricular cardiac muscle tissue development 1 P12883 356 1.17e-02 27 3 1 0.333 0.037 GO:0030239 BP 1 myofibril assembly 1 P11055 356 1.21e-02 2139 3 3 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P12883,P11055,Q9Y623 356 1.24e-02 53 3 1 0.333 0.019 TF:M04003_0 tf 1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 0 1 P11055 356 1.30e-02 30 3 1 0.333 0.033 GO:0035108 BP 1 limb morphogenesis 1 P11055 356 1.30e-02 30 3 1 0.333 0.033 GO:0055008 BP 1 cardiac muscle tissue morphogenesis 1 P12883 356 1.30e-02 30 3 1 0.333 0.033 GO:0035107 BP 1 appendage morphogenesis 1 P11055 356 1.32e-02 2200 3 3 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 1.35e-02 3035 3 3 1.000 0.001 TF:M02100_0 tf 1 Factor: MyoD; motif: CASCTGNCN; match class: 0 1 P12883,P11055,Q9Y623 356 1.38e-02 59 3 1 0.333 0.017 TF:M04631_1 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 1 1 P12883 356 1.43e-02 33 3 1 0.333 0.030 GO:0060415 BP 1 muscle tissue morphogenesis 1 P12883 356 1.43e-02 33 3 1 0.333 0.030 GO:0048644 BP 1 muscle organ morphogenesis 1 P12883 356 1.45e-02 62 3 1 0.333 0.016 TF:M06525_0 tf 1 Factor: ZNF431; motif: NGKTWGGGCAGA; match class: 0 1 P11055 356 1.47e-02 912 3 2 0.667 0.002 TF:M04288_1 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 1 1 P11055,Q9Y623 356 1.48e-02 63 3 1 0.333 0.016 TF:M06189_0 tf 1 Factor: ZNF91; motif: KGKTAGGRCAKA; match class: 0 1 P12883 356 1.61e-02 37 3 1 0.333 0.027 GO:0003208 BP 1 cardiac ventricle morphogenesis 1 P12883 356 1.69e-02 39 3 1 0.333 0.026 GO:0002027 BP 1 regulation of heart rate 1 P12883 356 1.74e-02 40 3 1 0.333 0.025 GO:0060173 BP 1 limb development 1 P11055 356 1.74e-02 40 3 1 0.333 0.025 GO:0048736 BP 1 appendage development 1 P11055 356 1.82e-02 42 3 1 0.333 0.024 GO:0010927 BP 1 cellular component assembly involved in morphogenesis 1 P11055 356 1.83e-02 2560 3 3 1.000 0.001 GO:0044710 BP 1 single-organism metabolic process 1 P12883,P11055,Q9Y623 356 1.95e-02 45 3 1 0.333 0.022 GO:0003231 BP 1 cardiac ventricle development 1 P12883 356 1.95e-02 45 3 1 0.333 0.022 GO:0055002 BP 1 striated muscle cell development 1 P11055 356 1.95e-02 7 3 1 0.333 0.143 OMIM:108120 omi 1 Distal Arthrogryposes 1 P11055 356 1.99e-02 46 3 1 0.333 0.022 GO:0006942 BP 1 regulation of striated muscle contraction 1 P12883 356 2.05e-02 3483 3 3 1.000 0.001 TF:M07266_1 tf 1 Factor: p300; motif: CTGNCTYMAN; match class: 1 1 P12883,P11055,Q9Y623 356 2.08e-02 48 3 1 0.333 0.021 GO:0003206 BP 1 cardiac chamber morphogenesis 1 P12883 356 2.08e-02 89 3 1 0.333 0.011 TF:M06132_0 tf 1 Factor: ZNF823; motif: NYYACCAGCCCT; match class: 0 1 P12883 356 2.11e-02 2574 3 3 1.000 0.001 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 2.25e-02 96 3 1 0.333 0.010 TF:M05944_0 tf 1 Factor: ZNF552; motif: NWTTGCTGRMGA; match class: 0 1 P11055 356 2.25e-02 52 3 1 0.333 0.019 GO:0003725 MF 1 double-stranded RNA binding 1 Q9Y623 356 2.27e-02 97 3 1 0.333 0.010 TF:M04005_0 tf 1 Factor: TCF7L1; motif: AAAGATCAAAGG; match class: 0 1 P11055 356 2.34e-02 54 3 1 0.333 0.019 GO:0055001 BP 1 muscle cell development 1 P11055 356 2.34e-02 54 3 1 0.333 0.019 GO:0004722 MF 1 protein serine/threonine phosphatase activity 1 P11055 356 2.38e-02 55 3 1 0.333 0.018 GO:0003205 BP 1 cardiac chamber development 1 P12883 356 2.47e-02 57 3 1 0.333 0.018 GO:0060048 BP 1 cardiac muscle contraction 1 P12883 356 2.51e-02 9 3 1 0.333 0.111 OMIM:604169 omi 1 Left Ventricular Noncompaction 1 P12883 356 2.51e-02 58 3 1 0.333 0.017 GO:0005516 MF 1 calmodulin binding 1 P11055 356 2.52e-02 3731 3 3 1.000 0.001 TF:M01591_0 tf 1 Factor: Tal-1; motif: CTTCCTTMTCTSY; match class: 0 1 P12883,P11055,Q9Y623 356 2.64e-02 1235 3 2 0.667 0.002 TF:M07210_0 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 0 1 P12883,Q9Y623 356 2.70e-02 3817 3 3 1.000 0.001 TF:M07345_0 tf 1 Factor: ZNF515; motif: SCTGCTGK; match class: 0 1 P12883,P11055,Q9Y623 356 2.73e-02 1256 3 2 0.667 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 P12883,P11055 356 2.81e-02 3869 3 3 1.000 0.001 TF:M01718_1 tf 1 Factor: NF-AT2; motif: TTTCCWN; match class: 1 1 P12883,P11055,Q9Y623 356 2.83e-02 2839 3 3 1.000 0.001 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 2.94e-02 68 3 1 0.333 0.015 GO:0006937 BP 1 regulation of muscle contraction 1 P12883 356 3.07e-02 71 3 1 0.333 0.014 GO:0048738 BP 1 cardiac muscle tissue development 1 P12883 356 3.13e-02 134 3 1 0.333 0.007 TF:M00186_0 tf 1 Factor: SRF; motif: GNCCAWATAWGGMN; match class: 0 1 P12883 356 3.16e-02 3073 3 3 1.000 0.001 GO:0032501 BP 1 multicellular organismal process 1 P12883,P11055,Q9Y623 356 3.17e-02 136 3 1 0.333 0.007 TF:M06262_0 tf 1 Factor: ZNF415; motif: NGGGGAAWCAGA; match class: 0 1 P12883 356 3.38e-02 145 3 1 0.333 0.007 TF:M00978_1 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 1 1 P11055 356 3.46e-02 80 3 1 0.333 0.013 GO:0051146 BP 1 striated muscle cell differentiation 1 P11055 356 3.48e-02 4156 3 3 1.000 0.001 TF:M02096_0 tf 1 Factor: ipf1; motif: YTAATGN; match class: 0 1 P12883,P11055,Q9Y623 356 3.56e-02 153 3 1 0.333 0.007 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 P12883 356 3.62e-02 44 3 1 0.333 0.023 KEGG:05416 keg 1 Viral myocarditis 1 P12883 356 3.67e-02 85 3 1 0.333 0.012 GO:0090257 BP 1 regulation of muscle system process 1 P12883 356 3.79e-02 163 3 1 0.333 0.006 TF:M05697_0 tf 1 Factor: ZNF235; motif: NCCGCWAAAYGC; match class: 0 1 Q9Y623 356 3.89e-02 90 3 1 0.333 0.011 GO:0051015 MF 1 actin filament binding 1 P11055 356 3.89e-02 90 3 1 0.333 0.011 GO:0003007 BP 1 heart morphogenesis 1 P12883 356 3.89e-02 1511 3 2 0.667 0.001 TF:M07137_0 tf 1 Factor: AP-2gamma; motif: NNNNSCCYCAGGSCN; match class: 0 1 P12883,P11055 356 3.97e-02 92 3 1 0.333 0.011 GO:0031032 BP 1 actomyosin structure organization 1 P11055 356 4.01e-02 4357 3 3 1.000 0.001 TF:M02028_0 tf 1 Factor: Pbx1; motif: ATCAATCAN; match class: 0 1 P12883,P11055,Q9Y623 356 4.26e-02 4447 3 3 1.000 0.001 TF:M07304_0 tf 1 Factor: Pbx; motif: NTGATTGANN; match class: 0 1 P12883,P11055,Q9Y623 356 4.33e-02 1107 3 2 0.667 0.002 GO:0009653 BP 1 anatomical structure morphogenesis 1 P12883,P11055 356 4.34e-02 3415 3 3 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 P12883,P11055,Q9Y623 356 4.34e-02 187 3 1 0.333 0.005 TF:M00733_1 tf 1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 1 P12883 356 4.37e-02 188 3 1 0.333 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 P11055 356 4.37e-02 1113 3 2 0.667 0.002 GO:0048513 BP 1 animal organ development 1 P12883,P11055 356 4.39e-02 1610 3 2 0.667 0.001 TF:M03563_1 tf 1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 1 P12883,Q9Y623 356 4.45e-02 3443 3 3 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P12883,P11055,Q9Y623 356 4.55e-02 3326 3 3 1.000 0.001 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.55e-02 3326 3 3 1.000 0.001 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.58e-02 3334 3 3 1.000 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.63e-02 3344 3 3 1.000 0.001 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.63e-02 3344 3 3 1.000 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.65e-02 1658 3 2 0.667 0.001 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 P11055,Q9Y623 356 4.70e-02 3361 3 3 1.000 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.70e-02 109 3 1 0.333 0.009 GO:0014706 BP 1 striated muscle tissue development 1 P12883 356 4.73e-02 3368 3 3 1.000 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.73e-02 3370 3 3 1.000 0.001 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.77e-02 3379 3 3 1.000 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.80e-02 3386 3 3 1.000 0.001 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.80e-02 3386 3 3 1.000 0.001 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.80e-02 3386 3 3 1.000 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.82e-02 3390 3 3 1.000 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.84e-02 1694 3 2 0.667 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 P12883,Q9Y623 356 4.87e-02 210 3 1 0.333 0.005 TF:M01117_1 tf 1 Factor: OTX; motif: GATTANNT; match class: 1 1 Q9Y623 356 4.87e-02 210 3 1 0.333 0.005 TF:M04326_1 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 1 1 P12883 356 4.87e-02 113 3 1 0.333 0.009 GO:0060537 BP 1 muscle tissue development 1 P12883 356 4.87e-02 3403 3 3 1.000 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.88e-02 3405 3 3 1.000 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.89e-02 3407 3 3 1.000 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.89e-02 3407 3 3 1.000 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.89e-02 3554 3 3 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 P12883,P11055,Q9Y623 356 4.91e-02 1706 3 2 0.667 0.001 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 P11055,Q9Y623 356 4.91e-02 3412 3 3 1.000 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.92e-02 3413 3 3 1.000 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.92e-02 3561 3 3 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P12883,P11055,Q9Y623 356 4.93e-02 3415 3 3 1.000 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.93e-02 3416 3 3 1.000 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.93e-02 3416 3 3 1.000 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.93e-02 3416 3 3 1.000 0.001 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.94e-02 3418 3 3 1.000 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.95e-02 3420 3 3 1.000 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.95e-02 3421 3 3 1.000 0.001 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.96e-02 3422 3 3 1.000 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.96e-02 3422 3 3 1.000 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.96e-02 3423 3 3 1.000 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.96e-02 3423 3 3 1.000 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.97e-02 3424 3 3 1.000 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.97e-02 3426 3 3 1.000 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.97e-02 3426 3 3 1.000 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.98e-02 3428 3 3 1.000 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.99e-02 3429 3 3 1.000 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.99e-02 3429 3 3 1.000 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.99e-02 3429 3 3 1.000 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 4.99e-02 3430 3 3 1.000 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3431 3 3 1.000 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 116 3 1 0.333 0.009 GO:0008016 BP 1 regulation of heart contraction 1 P12883 356 5.00e-02 3432 3 3 1.000 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3432 3 3 1.000 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3432 3 3 1.000 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 35 3 2 0.667 0.057 HP:0001611 hp 1 Nasal speech 1 P12883,P11055 356 5.00e-02 18 3 1 0.333 0.056 OMIM:192600 omi 1 Hypertrophic Cardiomyopathy 1 P12883 356 5.00e-02 3432 3 3 1.000 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 61 3 1 0.333 0.016 KEGG:04260 keg 1 Cardiac muscle contraction 1 P12883 356 5.00e-02 3432 3 3 1.000 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3432 3 3 1.000 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 356 5.00e-02 3432 3 3 1.000 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P12883,P11055,Q9Y623 357 9.43e-04 6 2 1 0.500 0.167 TF:M06180_1 tf 1 Factor: ZNF445; motif: NTGGGGGGAM; match class: 1 1 Q9H201 357 1.96e-03 564 2 2 1.000 0.004 TF:M07360_1 tf 1 Factor: LRH-1; motif: NNNYCAAGGYCAN; match class: 1 1 Q9H201,O95208 357 6.90e-03 44 2 1 0.500 0.023 TF:M06436_0 tf 1 Factor: ZNF836; motif: NTGGGCAAACKT; match class: 0 1 O95208 357 7.18e-03 1079 2 2 1.000 0.002 TF:M07267_1 tf 1 Factor: SF-1; motif: TGRCCTTGR; match class: 1 1 Q9H201,O95208 357 7.27e-03 1086 2 2 1.000 0.002 TF:M01719_0 tf 1 Factor: OTX2; motif: NRANGGATTARNN; match class: 0 1 Q9H201,O95208 357 9.86e-03 1264 2 2 1.000 0.002 TF:M00069_0 tf 1 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW; match class: 0 1 Q9H201,O95208 357 1.03e-02 66 2 1 0.500 0.015 TF:M06117_1 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 1 1 Q9H201 357 1.30e-02 1451 2 2 1.000 0.001 TF:M07417_0 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 0 1 Q9H201,O95208 357 1.32e-02 84 2 1 0.500 0.012 TF:M05865_0 tf 1 Factor: ZNF709; motif: NGYTCCAACACC; match class: 0 1 Q9H201 357 1.41e-02 1511 2 2 1.000 0.001 TF:M07137_0 tf 1 Factor: AP-2gamma; motif: NNNNSCCYCAGGSCN; match class: 0 1 Q9H201,O95208 357 1.72e-02 110 2 1 0.500 0.009 TF:M01142_1 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 1 1 O95208 357 1.74e-02 1681 2 2 1.000 0.001 TF:M01652_0 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 0 1 Q9H201,O95208 357 1.76e-02 1690 2 2 1.000 0.001 TF:M03802_1 tf 1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 1 Q9H201,O95208 357 2.51e-02 2018 2 2 1.000 0.001 TF:M00658_1 tf 1 Factor: PU.1; motif: WGAGGAAG; match class: 1 1 Q9H201,O95208 357 2.58e-02 2044 2 2 1.000 0.001 TF:M04326_0 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 0 1 Q9H201,O95208 357 2.72e-02 174 2 1 0.500 0.006 TF:M07137_1 tf 1 Factor: AP-2gamma; motif: NNNNSCCYCAGGSCN; match class: 1 1 Q9H201 357 2.84e-02 2144 2 2 1.000 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 Q9H201,O95208 357 3.16e-02 2264 2 2 1.000 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q9H201,O95208 357 3.17e-02 2267 2 2 1.000 0.001 TF:M07390_1 tf 1 Factor: Nfe2l1; motif: TGYNNAGTCATT; match class: 1 1 Q9H201,O95208 357 3.26e-02 2299 2 2 1.000 0.001 TF:M07246_0 tf 1 Factor: ATF-4; motif: NNTKRCRTCANS; match class: 0 1 Q9H201,O95208 357 3.35e-02 2331 2 2 1.000 0.001 TF:M02092_1 tf 1 Factor: Egr-2; motif: CCCMCNCN; match class: 1 1 Q9H201,O95208 357 3.64e-02 2428 2 2 1.000 0.001 TF:M02093_0 tf 1 Factor: ERR1; motif: CAAGGTCAMNN; match class: 0 1 Q9H201,O95208 357 3.72e-02 239 2 1 0.500 0.004 TF:M06564_0 tf 1 Factor: ZNF578; motif: KGGACGKGAAAA; match class: 0 1 O95208 357 3.85e-02 2497 2 2 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q9H201,O95208 357 3.87e-02 249 2 1 0.500 0.004 TF:M02098_1 tf 1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 1 1 Q9H201 357 3.89e-02 250 2 1 0.500 0.004 TF:M06697_0 tf 1 Factor: ZNF70; motif: NGGGGCGGMAKA; match class: 0 1 O95208 357 3.94e-02 253 2 1 0.500 0.004 TF:M04017_0 tf 1 Factor: IRF5; motif: NACCGAAACYA; match class: 0 1 O95208 357 3.98e-02 256 2 1 0.500 0.004 TF:M00055_0 tf 1 Factor: N-Myc; motif: NNCCACGTGNNN; match class: 0 1 O95208 357 4.41e-02 2674 2 2 1.000 0.001 TF:M01714_0 tf 1 Factor: KLF15; motif: GAGNNGGGGNGTDG; match class: 0 1 Q9H201,O95208 357 4.43e-02 285 2 1 0.500 0.004 TF:M00257_0 tf 1 Factor: RREB-1; motif: CCCCAAACMMCCCC; match class: 0 1 O95208 357 4.54e-02 2712 2 2 1.000 0.001 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 Q9H201,O95208 357 4.81e-02 310 2 1 0.500 0.003 TF:M00808_1 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 1 1 Q9H201 357 4.95e-02 98 2 1 0.500 0.010 GO:0019897 CC 1 extrinsic component of plasma membrane 1 Q9H201 357 4.95e-02 319 2 1 0.500 0.003 TF:M01830_0 tf 1 Factor: MAX; motif: CNNGMCACGTGN; match class: 0 1 O95208 357 4.98e-02 2840 2 2 1.000 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q9H201,O95208 357 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 O95208 357 5.00e-02 99 2 1 0.500 0.010 GO:0030136 CC 1 clathrin-coated vesicle 1 Q9H201 357 5.00e-02 229 2 2 1.000 0.009 KEGG:04144 keg 1 Endocytosis 1 Q9H201,O95208 358 1.93e-03 1 2 1 0.500 1.000 OMIM:612518 omi 1 CILIARY DYSKINESIA, PRIMARY, 10; CILD10;;CILIARY DYSKINESIA, PRIMARY, 10, WITH OR WITHOUT SITUS INVERSUS 1 Q9NVR5 358 1.93e-03 1 2 1 0.500 1.000 OMIM:616311 omi 1 MENTAL RETARDATION, AUTOSOMAL DOMINANT 33; MRD33 1 P42658 358 1.93e-03 1 2 1 0.500 1.000 OMIM:612956 omi 1 VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 2; VF2 1 P42658 358 2.72e-03 2 2 1 0.500 0.500 HP:0001137 hp 1 Alternating esotropia 1 P42658 358 6.80e-03 5 2 1 0.500 0.200 HP:0011094 hp 1 Overbite 1 P42658 358 1.11e-02 2 2 1 0.500 0.500 GO:0097588 BP 1 archaeal or bacterial-type flagellum-dependent cell motility 1 Q9NVR5 358 1.11e-02 2 2 1 0.500 0.500 GO:0071973 BP 1 bacterial-type flagellum-dependent cell motility 1 Q9NVR5 358 2.44e-02 18 2 1 0.500 0.056 HP:0001663 hp 1 Ventricular fibrillation 1 P42658 358 2.60e-02 141 2 1 0.500 0.007 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 P42658 358 3.66e-02 27 2 1 0.500 0.037 HP:0200106 hp 1 Absent/shortened dynein arms 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0200073 hp 1 Respiratory insufficiency due to defective ciliary clearance 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0005938 hp 1 Abnormal respiratory motile cilium morphology 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012259 hp 1 Absent inner and outer dynein arms 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012258 hp 1 Abnormal axonemal organization of respiratory motile cilia 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0200108 hp 1 Shortened outer dynein arms 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012253 hp 1 Abnormal respiratory epithelium morphology 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012260 hp 1 Abnormal central microtubular pair morphology of respiratory motile cilia 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012257 hp 1 Absent inner dynein arms 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0200109 hp 1 Absent/shortened outer dynein arms 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012255 hp 1 Dynein arm defect of respiratory motile cilia 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012267 hp 1 Absent respiratory ciliary axoneme radial spokes 1 Q9NVR5 358 3.66e-02 27 2 1 0.500 0.037 HP:0012256 hp 1 Absent outer dynein arms 1 Q9NVR5 358 3.79e-02 28 2 1 0.500 0.036 HP:0012265 hp 1 Ciliary dyskinesia 1 Q9NVR5 358 3.79e-02 28 2 1 0.500 0.036 HP:0012208 hp 1 Nonmotile sperm 1 Q9NVR5 358 4.06e-02 30 2 1 0.500 0.033 HP:0012207 hp 1 Reduced sperm motility 1 Q9NVR5 358 4.06e-02 30 2 1 0.500 0.033 HP:0000666 hp 1 Horizontal nystagmus 1 P42658 358 4.06e-02 30 2 1 0.500 0.033 HP:0012206 hp 1 Abnormal sperm motility 1 Q9NVR5 358 4.19e-02 31 2 1 0.500 0.032 HP:0012735 hp 1 Cough 1 Q9NVR5 358 4.19e-02 31 2 1 0.500 0.032 HP:0002257 hp 1 Chronic rhinitis 1 Q9NVR5 358 4.46e-02 33 2 1 0.500 0.030 HP:0100582 hp 1 Nasal polyposis 1 Q9NVR5 358 4.60e-02 34 2 1 0.500 0.029 HP:0012384 hp 1 Rhinitis 1 Q9NVR5 358 4.60e-02 34 2 1 0.500 0.029 HP:0000389 hp 1 Chronic otitis media 1 Q9NVR5 358 4.73e-02 35 2 1 0.500 0.029 HP:0011109 hp 1 Chronic sinusitis 1 Q9NVR5 358 4.73e-02 35 2 1 0.500 0.029 HP:0004469 hp 1 Chronic bronchitis 1 Q9NVR5 358 4.73e-02 35 2 1 0.500 0.029 HP:0002688 hp 1 Absent frontal sinuses 1 Q9NVR5 358 4.87e-02 36 2 1 0.500 0.028 HP:0002687 hp 1 Abnormality of frontal sinus 1 Q9NVR5 358 4.87e-02 36 2 1 0.500 0.028 HP:0009119 hp 1 Aplasia/Hypoplasia of the frontal sinuses 1 Q9NVR5 358 4.87e-02 36 2 1 0.500 0.028 HP:0001748 hp 1 Polysplenia 1 Q9NVR5 358 4.87e-02 36 2 1 0.500 0.028 HP:0000433 hp 1 Abnormality of the nasal mucosa 1 Q9NVR5 358 5.00e-02 26 2 1 0.500 0.038 OMIM:244400 omi 1 Primary Ciliary Dyskinesia 1 Q9NVR5 358 5.00e-02 37 2 1 0.500 0.027 HP:0010055 hp 1 Broad hallux 1 P42658 359 5.29e-03 2218 3 3 1.000 0.001 TF:M04077_1 tf 1 Factor: POU3F1; motif: WTGMATAAWTNA; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 5.29e-03 2 3 1 0.333 0.500 GO:0032089 MF 1 NACHT domain binding 1 Q9Y2G2 359 6.66e-03 610 3 2 0.667 0.003 TF:M06005_0 tf 1 Factor: ZSCAN11; motif: NYMKAGGAAASA; match class: 0 1 Q9Y2G2,Q5T3J3 359 8.46e-03 36 3 1 0.333 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 Q9Y2G2 359 1.02e-02 2762 3 3 1.000 0.001 TF:M04317_1 tf 1 Factor: EN1; motif: TAATTRSNYAATTA; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 1.06e-02 4 3 1 0.333 0.250 GO:0072559 CC 1 NLRP3 inflammasome complex 1 Q9Y2G2 359 1.08e-02 781 3 2 0.667 0.003 TF:M04448_0 tf 1 Factor: VENTX; motif: ANCGATTAR; match class: 0 1 Q5T3J3,Q8IWC1 359 1.15e-02 49 3 1 0.333 0.020 TF:M00672_1 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 1 1 Q9Y2G2 359 1.22e-02 52 3 1 0.333 0.019 TF:M05427_1 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 1 1 Q5T3J3 359 1.24e-02 53 3 1 0.333 0.019 TF:M03922_0 tf 1 Factor: SP4; motif: NWRGCCACGCCCMCTYN; match class: 0 1 Q5T3J3 359 1.27e-02 54 3 1 0.333 0.019 TF:M01023_0 tf 1 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 0 1 Q5T3J3 359 1.38e-02 59 3 1 0.333 0.017 TF:M06569_0 tf 1 Factor: ZNF775; motif: NYGGGAAAATW; match class: 0 1 Q8IWC1 359 1.50e-02 64 3 1 0.333 0.016 TF:M05826_0 tf 1 Factor: ZNF66; motif: GTSTTCAACTWA; match class: 0 1 Q8IWC1 359 1.59e-02 6 3 1 0.333 0.167 GO:0061702 CC 1 inflammasome complex 1 Q9Y2G2 359 1.92e-02 3408 3 3 1.000 0.001 TF:M07257_1 tf 1 Factor: HOXA10; motif: TTATNNYWN; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 1.92e-02 82 3 1 0.333 0.012 TF:M07410_1 tf 1 Factor: RFX2; motif: GTYNCCATGGCAACNGNNN; match class: 1 1 Q5T3J3 359 1.96e-02 1060 3 2 0.667 0.002 TF:M05427_0 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 0 1 Q9Y2G2,Q5T3J3 359 2.08e-02 1091 3 2 0.667 0.002 TF:M00302_1 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 1 1 Q9Y2G2,Q5T3J3 359 2.14e-02 1109 3 2 0.667 0.002 TF:M07311_0 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 0 1 Q9Y2G2,Q8IWC1 359 2.49e-02 1197 3 2 0.667 0.002 TF:M04405_0 tf 1 Factor: MSX1; motif: NCAATTAN; match class: 0 1 Q5T3J3,Q8IWC1 359 2.50e-02 1200 3 2 0.667 0.002 TF:M04042_0 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 0 1 Q9Y2G2,Q5T3J3 359 2.59e-02 111 3 1 0.333 0.009 TF:M04197_0 tf 1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 0 1 Q5T3J3 359 3.01e-02 1323 3 2 0.667 0.002 TF:M00489_1 tf 1 Factor: Nkx6-2; motif: NWADTAAWTANN; match class: 1 1 Q9Y2G2,Q5T3J3 359 3.12e-02 4006 3 3 1.000 0.001 TF:M00792_1 tf 1 Factor: SMAD; motif: AGACNBCNN; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 3.17e-02 12 3 1 0.333 0.083 GO:0050718 BP 1 positive regulation of interleukin-1 beta secretion 1 Q9Y2G2 359 3.24e-02 1374 3 2 0.667 0.001 TF:M00478_0 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 0 1 Q9Y2G2,Q8IWC1 359 3.25e-02 1375 3 2 0.667 0.001 TF:M02074_1 tf 1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 1 Q9Y2G2,Q5T3J3 359 3.25e-02 4062 3 3 1.000 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 3.39e-02 4118 3 3 1.000 0.001 TF:M00471_0 tf 1 Factor: TBP; motif: TATAAATW; match class: 0 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 3.43e-02 13 3 1 0.333 0.077 GO:0050716 BP 1 positive regulation of interleukin-1 secretion 1 Q9Y2G2 359 3.49e-02 150 3 1 0.333 0.007 TF:M06119_1 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 1 1 Q5T3J3 359 3.61e-02 1453 3 2 0.667 0.001 TF:M00147_1 tf 1 Factor: HSF2; motif: NGAANNWTCK; match class: 1 1 Q9Y2G2,Q5T3J3 359 3.68e-02 4233 3 3 1.000 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 3.70e-02 14 3 1 0.333 0.071 GO:0008656 MF 1 cysteine-type endopeptidase activator activity involved in apoptotic process 1 Q9Y2G2 359 3.73e-02 1478 3 2 0.667 0.001 TF:M00630_1 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 1 1 Q9Y2G2,Q8IWC1 359 3.73e-02 136 3 1 0.333 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q9Y2G2 359 3.96e-02 15 3 1 0.333 0.067 GO:0050706 BP 1 regulation of interleukin-1 beta secretion 1 Q9Y2G2 359 3.96e-02 15 3 1 0.333 0.067 GO:0016505 MF 1 peptidase activator activity involved in apoptotic process 1 Q9Y2G2 359 4.14e-02 178 3 1 0.333 0.006 TF:M07100_0 tf 1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 0 1 Q5T3J3 359 4.16e-02 4411 3 3 1.000 0.001 TF:M00302_0 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 0 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 4.16e-02 1565 3 2 0.667 0.001 TF:M00422_1 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 1 1 Q9Y2G2,Q8IWC1 359 4.22e-02 1576 3 2 0.667 0.001 TF:M00086_1 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 1 1 Q9Y2G2,Q8IWC1 359 4.37e-02 188 3 1 0.333 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q9Y2G2 359 4.49e-02 17 3 1 0.333 0.059 GO:0032731 BP 1 positive regulation of interleukin-1 beta production 1 Q9Y2G2 359 4.49e-02 17 3 1 0.333 0.059 GO:0050704 BP 1 regulation of interleukin-1 secretion 1 Q9Y2G2 359 4.69e-02 1666 3 2 0.667 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q9Y2G2,Q8IWC1 359 4.82e-02 208 3 1 0.333 0.005 TF:M06849_0 tf 1 Factor: ZNF528; motif: NSTCCGGAAGA; match class: 0 1 Q5T3J3 359 4.91e-02 212 3 1 0.333 0.005 TF:M04042_1 tf 1 Factor: MYBL1; motif: ACCGTTAAACNG; match class: 1 1 Q9Y2G2 359 4.92e-02 1708 3 2 0.667 0.001 TF:M00203_0 tf 1 Factor: GATA-X; motif: NGATAAGNMNN; match class: 0 1 Q9Y2G2,Q8IWC1 359 4.95e-02 4673 3 3 1.000 0.001 TF:M04300_1 tf 1 Factor: DLX2; motif: NYAATTAN; match class: 1 1 Q9Y2G2,Q5T3J3,Q8IWC1 359 5.00e-02 408 3 2 0.667 0.005 MI:hsa-miR-570 mi 1 MI:hsa-miR-570 1 Q5T3J3,Q8IWC1 359 5.00e-02 474 3 2 0.667 0.004 GO:0005815 CC 1 microtubule organizing center 1 Q5T3J3,Q8IWC1 360 1.22e-03 1 2 1 0.500 1.000 GO:0030109 MF 1 HLA-B specific inhibitory MHC class I receptor activity 1 P43629 360 1.22e-03 1 2 1 0.500 1.000 GO:0032396 MF 1 inhibitory MHC class I receptor activity 1 P43629 360 4.89e-03 4 2 1 0.500 0.250 GO:0032393 MF 1 MHC class I receptor activity 1 P43629 360 1.20e-02 20 2 1 0.500 0.050 KEGG:05332 keg 1 Graft-versus-host disease 1 P43629 360 1.34e-02 11 2 1 0.500 0.091 GO:0001530 MF 1 lipopolysaccharide binding 1 Q96DR5 360 2.69e-02 45 2 1 0.500 0.022 KEGG:04612 keg 1 Antigen processing and presentation 1 P43629 360 3.05e-02 25 2 1 0.500 0.040 GO:0042267 BP 1 natural killer cell mediated cytotoxicity 1 P43629 360 3.05e-02 25 2 1 0.500 0.040 GO:0002228 BP 1 natural killer cell mediated immunity 1 P43629 360 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 Q96DR5 360 4.63e-02 38 2 1 0.500 0.026 GO:0001909 BP 1 leukocyte mediated cytotoxicity 1 P43629 360 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-877* mi 1 MI:hsa-miR-877* 1 Q96DR5 360 5.00e-02 2 2 1 0.500 0.500 TF:M06405_0 tf 1 Factor: ZNF329; motif: NTGTACTGCMTA; match class: 0 1 Q96DR5 360 5.00e-02 84 2 1 0.500 0.012 KEGG:04650 keg 1 Natural killer cell mediated cytotoxicity 1 P43629 360 5.00e-02 41 2 1 0.500 0.024 GO:0001906 BP 1 cell killing 1 P43629 361 4.55e-03 1 4 1 0.250 1.000 GO:0004569 MF 1 glycoprotein endo-alpha-1,2-mannosidase activity 1 Q5SRI9 361 1.82e-02 4 4 1 0.250 0.250 GO:0051152 BP 1 positive regulation of smooth muscle cell differentiation 1 O95897 361 2.27e-02 5 4 1 0.250 0.200 GO:0003190 BP 1 atrioventricular valve formation 1 Q99784 361 2.73e-02 6 4 1 0.250 0.167 GO:0023041 BP 1 neuronal signal transduction 1 Q99784 361 2.73e-02 6 4 1 0.250 0.167 GO:0003188 BP 1 heart valve formation 1 Q99784 361 3.42e-02 368 4 2 0.500 0.005 MI:hsa-miR-372 mi 1 MI:hsa-miR-372 1 Q8WYA1,Q5SRI9 361 3.97e-02 397 4 2 0.500 0.005 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 Q8WYA1,Q99784 361 4.07e-02 402 4 2 0.500 0.005 MI:hsa-miR-34a* mi 1 MI:hsa-miR-34a* 1 Q99784,Q5SRI9 361 4.09e-02 9 4 1 0.250 0.111 GO:0044295 CC 1 axonal growth cone 1 Q99784 361 4.09e-02 9 4 1 0.250 0.111 GO:0042753 BP 1 positive regulation of circadian rhythm 1 Q8WYA1 361 4.20e-02 409 4 2 0.500 0.005 MI:hsa-miR-641 mi 1 MI:hsa-miR-641 1 O95897,Q99784 361 4.49e-02 423 4 2 0.500 0.005 MI:hsa-miR-628-3p mi 1 MI:hsa-miR-628-3p 1 Q99784,Q5SRI9 361 4.87e-02 441 4 2 0.500 0.005 MI:hsa-miR-768-5p mi 1 MI:hsa-miR-768-5p 1 Q99784,Q5SRI9 361 5.00e-02 11 4 1 0.250 0.091 GO:0051150 BP 1 regulation of smooth muscle cell differentiation 1 O95897 361 5.00e-02 11 4 1 0.250 0.091 GO:0003181 BP 1 atrioventricular valve morphogenesis 1 Q99784 361 5.00e-02 5 4 1 0.250 0.200 REAC:964739 rea 1 N-glycan trimming and elongation in the cis-Golgi 1 Q5SRI9 361 5.00e-02 447 4 2 0.500 0.004 MI:hsa-miR-872 mi 1 MI:hsa-miR-872 1 Q99784,Q5SRI9 361 5.00e-02 1 4 1 0.250 1.000 TF:M06272_1 tf 1 Factor: ZNF569; motif: KGKGGGTGRATM; match class: 1 1 Q99784 361 5.00e-02 11 4 1 0.250 0.091 GO:0032281 CC 1 AMPA glutamate receptor complex 1 O95897 361 5.00e-02 1 4 1 0.250 1.000 TF:M05522_1 tf 1 Factor: ZNF341; motif: NTGGGGGGGGGG; match class: 1 1 Q99784 362 8.89e-08 19 4 3 0.750 0.158 REAC:428930 rea 1 Thromboxane signalling through TP receptor 1 P29992,P50148,P62879 362 1.05e-07 20 4 3 0.750 0.150 REAC:418592 rea 1 ADP signalling through P2Y purinoceptor 1 1 P29992,P50148,P62879 362 2.11e-07 25 4 3 0.750 0.120 REAC:456926 rea 1 Thrombin signalling through proteinase activated receptors (PARs) 1 P29992,P50148,P62879 362 2.68e-07 27 4 3 0.750 0.111 REAC:392518 rea 1 Signal amplification 1 P29992,P50148,P62879 362 3.53e-07 2 4 2 0.500 1.000 GO:0031826 MF 1 type 2A serotonin receptor binding 1 P29992,P50148 362 3.79e-07 6 4 3 0.750 0.500 CORUM:117 cor 1 GPR56-CD81-Galphaq/11-Gbeta complex 1 P29992,P50148,P62879 362 3.32e-06 5 4 2 0.500 0.400 REAC:434316 rea 1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 1 P29992,P50148 362 3.32e-06 5 4 2 0.500 0.400 REAC:400451 rea 1 Free fatty acids regulate insulin secretion 1 P29992,P50148 362 3.53e-06 5 4 2 0.500 0.400 GO:0031821 MF 1 G-protein coupled serotonin receptor binding 1 P29992,P50148 362 3.99e-06 65 4 3 0.750 0.046 REAC:422356 rea 1 Regulation of insulin secretion 1 P29992,P50148,P62879 362 4.98e-06 6 4 2 0.500 0.333 REAC:399997 rea 1 Acetylcholine regulates insulin secretion 1 P29992,P50148 362 5.29e-06 6 4 2 0.500 0.333 GO:0060158 BP 1 phospholipase C-activating dopamine receptor signaling pathway 1 P29992,P50148 362 1.00e-05 88 4 3 0.750 0.034 REAC:416476 rea 1 G alpha (q) signalling events 1 P29992,P50148,P62879 362 1.22e-05 94 4 3 0.750 0.032 REAC:163685 rea 1 Integration of energy metabolism 1 P29992,P50148,P62879 362 1.27e-05 9 4 2 0.500 0.222 GO:0095500 BP 1 acetylcholine receptor signaling pathway 1 P29992,P50148 362 1.27e-05 9 4 2 0.500 0.222 GO:1905144 BP 1 response to acetylcholine 1 P29992,P50148 362 1.27e-05 9 4 2 0.500 0.222 GO:1903831 BP 1 signal transduction involved in cellular response to ammonium ion 1 P29992,P50148 362 1.27e-05 9 4 2 0.500 0.222 GO:1905145 BP 1 cellular response to acetylcholine 1 P29992,P50148 362 1.27e-05 9 4 2 0.500 0.222 GO:0007213 BP 1 G-protein coupled acetylcholine receptor signaling pathway 1 P29992,P50148 362 3.91e-05 158 4 3 0.750 0.019 GO:0003924 MF 1 GTPase activity 1 P29992,P50148,P62879 362 4.23e-05 16 4 2 0.500 0.125 GO:0007603 BP 1 phototransduction, visible light 1 P29992,P50148 362 4.23e-05 16 4 2 0.500 0.125 GO:0001750 CC 1 photoreceptor outer segment 1 P29992,P50148 362 5.39e-05 18 4 2 0.500 0.111 GO:0009649 BP 1 entrainment of circadian clock 1 P29992,P50148 362 5.56e-05 88 4 3 0.750 0.034 KEGG:04725 keg 1 Cholinergic synapse 1 P29992,P50148,P62879 362 6.03e-05 19 4 2 0.500 0.105 GO:0071242 BP 1 cellular response to ammonium ion 1 P29992,P50148 362 6.81e-05 190 4 3 0.750 0.016 GO:0098852 CC 1 lytic vacuole membrane 1 P29992,P50148,P62879 362 6.81e-05 190 4 3 0.750 0.016 GO:0005765 CC 1 lysosomal membrane 1 P29992,P50148,P62879 362 8.91e-05 23 4 2 0.500 0.087 GO:0009584 BP 1 detection of visible light 1 P29992,P50148 362 8.91e-05 23 4 2 0.500 0.087 GO:0060359 BP 1 response to ammonium ion 1 P29992,P50148 362 9.72e-05 24 4 2 0.500 0.083 GO:0007212 BP 1 dopamine receptor signaling pathway 1 P29992,P50148 362 1.00e-04 216 4 3 0.750 0.014 GO:0005774 CC 1 vacuolar membrane 1 P29992,P50148,P62879 362 1.14e-04 26 4 2 0.500 0.077 GO:0007602 BP 1 phototransduction 1 P29992,P50148 362 1.43e-04 213 4 3 0.750 0.014 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 P29992,P50148,P62879 362 1.43e-04 29 4 2 0.500 0.069 GO:0097733 CC 1 photoreceptor cell cilium 1 P29992,P50148 362 1.53e-04 30 4 2 0.500 0.067 GO:0097732 CC 1 9+2 non-motile cilium 1 P29992,P50148 362 1.75e-04 32 4 2 0.500 0.062 GO:0009583 BP 1 detection of light stimulus 1 P29992,P50148 362 2.15e-04 279 4 3 0.750 0.011 GO:0044437 CC 1 vacuolar part 1 P29992,P50148,P62879 362 2.22e-04 36 4 2 0.500 0.056 GO:0007200 BP 1 phospholipase C-activating G-protein coupled receptor signaling pathway 1 P29992,P50148 362 2.88e-04 41 4 2 0.500 0.049 GO:0097730 CC 1 non-motile cilium 1 P29992,P50148 362 3.10e-04 315 4 3 0.750 0.010 GO:1901699 BP 1 cellular response to nitrogen compound 1 P29992,P50148,P62879 362 3.48e-04 287 4 3 0.750 0.010 REAC:881907 rea 1 Gastrin-CREB signalling pathway via PKC and MAPK 1 P29992,P50148,P62879 362 3.96e-04 342 4 3 0.750 0.009 GO:0000323 CC 1 lytic vacuole 1 P29992,P50148,P62879 362 3.96e-04 342 4 3 0.750 0.009 GO:0005764 CC 1 lysosome 1 P29992,P50148,P62879 362 3.96e-04 48 4 2 0.500 0.042 GO:0009581 BP 1 detection of external stimulus 1 P29992,P50148 362 4.13e-04 49 4 2 0.500 0.041 GO:0009582 BP 1 detection of abiotic stimulus 1 P29992,P50148 362 4.50e-04 357 4 3 0.750 0.008 GO:0007186 BP 1 G-protein coupled receptor signaling pathway 1 P29992,P50148,P62879 362 5.34e-04 378 4 3 0.750 0.008 GO:1901698 BP 1 response to nitrogen compound 1 P29992,P50148,P62879 362 5.60e-04 57 4 2 0.500 0.035 GO:0042752 BP 1 regulation of circadian rhythm 1 P29992,P50148 362 5.86e-04 342 4 3 0.750 0.009 REAC:388396 rea 1 GPCR downstream signaling 1 P29992,P50148,P62879 362 6.04e-04 394 4 3 0.750 0.008 GO:0005773 CC 1 vacuole 1 P29992,P50148,P62879 362 8.22e-04 69 4 2 0.500 0.029 GO:0001508 BP 1 action potential 1 P29992,P50148 362 8.32e-04 1394 4 4 1.000 0.003 GO:0010033 BP 1 response to organic substance 1 P29992,P29317,P50148,P62879 362 8.62e-04 444 4 3 0.750 0.007 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P29992,P50148,P62879 362 9.03e-04 1423 4 4 1.000 0.003 GO:0070887 BP 1 cellular response to chemical stimulus 1 P29992,P29317,P50148,P62879 362 1.27e-03 444 4 3 0.750 0.007 REAC:109582 rea 1 Hemostasis 1 P29992,P50148,P62879 362 1.36e-03 1 4 1 0.250 1.000 GO:0060444 BP 1 branching involved in mammary gland duct morphogenesis 1 P29317 362 1.36e-03 1 4 1 0.250 1.000 GO:0070309 BP 1 lens fiber cell morphogenesis 1 P29317 362 1.63e-03 97 4 2 0.500 0.021 GO:0007623 BP 1 circadian rhythm 1 P29992,P50148 362 1.63e-03 51 4 2 0.500 0.039 KEGG:04730 keg 1 Long-term depression 1 P29992,P50148 362 1.66e-03 553 4 3 0.750 0.005 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P29992,P50148,P62879 362 1.66e-03 98 4 2 0.500 0.020 GO:0001664 MF 1 G-protein coupled receptor binding 1 P29992,P50148 362 1.97e-03 586 4 3 0.750 0.005 GO:1901700 BP 1 response to oxygen-containing compound 1 P29992,P50148,P62879 362 2.01e-03 590 4 3 0.750 0.005 GO:0016462 MF 1 pyrophosphatase activity 1 P29992,P50148,P62879 362 2.02e-03 108 4 2 0.500 0.019 GO:0030168 BP 1 platelet activation 1 P29992,P50148 362 2.03e-03 592 4 3 0.750 0.005 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P29992,P50148,P62879 362 2.03e-03 592 4 3 0.750 0.005 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P29992,P50148,P62879 362 2.41e-03 118 4 2 0.500 0.017 GO:0048511 BP 1 rhythmic process 1 P29992,P50148 362 2.74e-03 66 4 2 0.500 0.030 KEGG:04911 keg 1 Insulin secretion 1 P29992,P50148 362 2.74e-03 66 4 2 0.500 0.030 KEGG:04925 keg 1 Aldosterone synthesis and secretion 1 P29992,P50148 362 2.75e-03 577 4 3 0.750 0.005 REAC:372790 rea 1 Signaling by GPCR 1 P29992,P50148,P62879 362 2.77e-03 1882 4 4 1.000 0.002 GO:0042221 BP 1 response to chemical 1 P29992,P29317,P50148,P62879 362 2.77e-03 325 4 3 0.750 0.009 KEGG:05200 keg 1 Pathways in cancer 1 P29992,P50148,P62879 362 3.43e-03 141 4 2 0.500 0.014 GO:0051606 BP 1 detection of stimulus 1 P29992,P50148 362 3.63e-03 76 4 2 0.500 0.026 KEGG:05146 keg 1 Amoebiasis 1 P29992,P50148 362 3.63e-03 76 4 2 0.500 0.026 KEGG:04912 keg 1 GnRH signaling pathway 1 P29992,P50148 362 3.74e-03 728 4 3 0.750 0.004 GO:0042995 CC 1 cell projection 1 P29992,P29317,P50148 362 4.02e-03 80 4 2 0.500 0.025 KEGG:04723 keg 1 Retrograde endocannabinoid signaling 1 P50148,P62879 362 4.07e-03 3 4 1 0.250 0.333 GO:0070307 BP 1 lens fiber cell development 1 P29317 362 4.07e-03 3 4 1 0.250 0.333 GO:0060603 BP 1 mammary gland duct morphogenesis 1 P29317 362 4.12e-03 81 4 2 0.500 0.025 KEGG:04713 keg 1 Circadian entrainment 1 P50148,P62879 362 4.12e-03 81 4 2 0.500 0.025 KEGG:04540 keg 1 Gap junction 1 P29992,P50148 362 4.12e-03 81 4 2 0.500 0.025 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 P29992,P50148 362 4.19e-03 156 4 2 0.500 0.013 GO:0009416 BP 1 response to light stimulus 1 P29992,P50148 362 4.23e-03 759 4 3 0.750 0.004 GO:0098805 CC 1 whole membrane 1 P29992,P50148,P62879 362 4.32e-03 83 4 2 0.500 0.024 KEGG:04726 keg 1 Serotonergic synapse 1 P50148,P62879 362 4.53e-03 85 4 2 0.500 0.024 KEGG:04270 keg 1 Vascular smooth muscle contraction 1 P29992,P50148 362 5.43e-03 4 4 1 0.250 0.250 GO:0070306 BP 1 lens fiber cell differentiation 1 P29317 362 5.43e-03 4 4 1 0.250 0.250 GO:0002089 BP 1 lens morphogenesis in camera-type eye 1 P29317 362 5.57e-03 180 4 2 0.500 0.011 GO:0042391 BP 1 regulation of membrane potential 1 P29992,P50148 362 5.60e-03 835 4 3 0.750 0.004 GO:0009605 BP 1 response to external stimulus 1 P29992,P29317,P50148 362 5.65e-03 95 4 2 0.500 0.021 KEGG:04724 keg 1 Glutamatergic synapse 1 P50148,P62879 362 6.78e-03 5 4 1 0.250 0.200 GO:0060443 BP 1 mammary gland morphogenesis 1 P29317 362 7.57e-03 2420 4 4 1.000 0.002 GO:0005886 CC 1 plasma membrane 1 P29992,P29317,P50148,P62879 362 7.69e-03 111 4 2 0.500 0.018 KEGG:04728 keg 1 Dopaminergic synapse 1 P50148,P62879 362 8.06e-03 945 4 3 0.750 0.003 GO:0098588 CC 1 bounding membrane of organelle 1 P29992,P50148,P62879 362 8.10e-03 808 4 3 0.750 0.004 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 P29992,P29317,P62879 362 8.20e-03 2469 4 4 1.000 0.002 GO:0071944 CC 1 cell periphery 1 P29992,P29317,P50148,P62879 362 8.29e-03 220 4 2 0.500 0.009 GO:0044441 CC 1 ciliary part 1 P29992,P50148 362 8.37e-03 221 4 2 0.500 0.009 GO:0007596 BP 1 blood coagulation 1 P29992,P50148 362 8.52e-03 223 4 2 0.500 0.009 GO:0007599 BP 1 hemostasis 1 P29992,P50148 362 8.60e-03 224 4 2 0.500 0.009 GO:0050817 BP 1 coagulation 1 P29992,P50148 362 9.29e-03 233 4 2 0.500 0.009 GO:0009314 BP 1 response to radiation 1 P29992,P50148 362 1.05e-02 4 4 1 0.250 0.250 TF:M06516_1 tf 1 Factor: ZNF418; motif: NGGGKAGCCGT; match class: 1 1 P50148 362 1.09e-02 8 4 1 0.250 0.125 GO:0033598 BP 1 mammary gland epithelial cell proliferation 1 P29317 362 1.12e-02 134 4 2 0.500 0.015 KEGG:04020 keg 1 Calcium signaling pathway 1 P29992,P50148 362 1.13e-02 135 4 2 0.500 0.015 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 P29992,P50148 362 1.20e-02 15 4 1 0.250 0.067 REAC:997272 rea 1 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 1 P62879 362 1.20e-02 15 4 1 0.250 0.067 REAC:1296041 rea 1 Activation of G protein gated Potassium channels 1 P62879 362 1.20e-02 15 4 1 0.250 0.067 REAC:1296059 rea 1 G protein gated Potassium channels 1 P62879 362 1.22e-02 267 4 2 0.500 0.007 GO:0005929 CC 1 cilium 1 P29992,P50148 362 1.22e-02 268 4 2 0.500 0.007 GO:0050878 BP 1 regulation of body fluid levels 1 P29992,P50148 362 1.28e-02 16 4 1 0.250 0.062 REAC:392851 rea 1 Prostacyclin signalling through prostacyclin receptor 1 P62879 362 1.36e-02 17 4 1 0.250 0.059 REAC:420092 rea 1 Glucagon-type ligand receptors 1 P62879 362 1.43e-02 18 4 1 0.250 0.056 REAC:418217 rea 1 G beta:gamma signalling through PLC beta 1 P62879 362 1.45e-02 292 4 2 0.500 0.007 GO:0051345 BP 1 positive regulation of hydrolase activity 1 P29317,P50148 362 1.49e-02 155 4 2 0.500 0.013 KEGG:04015 keg 1 Rap1 signaling pathway 1 P29317,P50148 362 1.49e-02 11 4 1 0.250 0.091 GO:0002088 BP 1 lens development in camera-type eye 1 P29317 362 1.51e-02 19 4 1 0.250 0.053 REAC:500657 rea 1 Presynaptic function of Kainate receptors 1 P62879 362 1.53e-02 300 4 2 0.500 0.007 GO:0042060 BP 1 wound healing 1 P29992,P50148 362 1.59e-02 20 4 1 0.250 0.050 REAC:1296065 rea 1 Inwardly rectifying K+ channels 1 P62879 362 1.59e-02 20 4 1 0.250 0.050 REAC:392170 rea 1 ADP signalling through P2Y purinoceptor 12 1 P62879 362 1.70e-02 166 4 2 0.500 0.012 KEGG:04014 keg 1 Ras signaling pathway 1 P29317,P62879 362 1.80e-02 3004 4 4 1.000 0.001 GO:0007165 BP 1 signal transduction 1 P29992,P29317,P50148,P62879 362 1.83e-02 23 4 1 0.250 0.043 REAC:202040 rea 1 G-protein activation 1 P62879 362 1.88e-02 333 4 2 0.500 0.006 GO:0005925 CC 1 focal adhesion 1 P29317,P62879 362 1.88e-02 333 4 2 0.500 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 P29317,P62879 362 1.89e-02 334 4 2 0.500 0.006 GO:0009611 BP 1 response to wounding 1 P29992,P50148 362 1.92e-02 337 4 2 0.500 0.006 GO:0030055 CC 1 cell-substrate junction 1 P29317,P62879 362 1.99e-02 25 4 1 0.250 0.040 REAC:400042 rea 1 Adrenaline,noradrenaline inhibits insulin secretion 1 P62879 362 2.03e-02 15 4 1 0.250 0.067 GO:0022612 BP 1 gland morphogenesis 1 P29317 362 2.03e-02 15 4 1 0.250 0.067 GO:0007202 BP 1 activation of phospholipase C activity 1 P50148 362 2.15e-02 27 4 1 0.250 0.037 REAC:451326 rea 1 Activation of Kainate Receptors upon glutamate binding 1 P62879 362 2.17e-02 16 4 1 0.250 0.062 GO:0035412 BP 1 regulation of catenin import into nucleus 1 P50148 362 2.23e-02 28 4 1 0.250 0.036 REAC:3928663 rea 1 EPHA-mediated growth cone collapse 1 P29317 362 2.28e-02 368 4 2 0.500 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 P29317,P50148 362 2.30e-02 17 4 1 0.250 0.059 GO:0035411 BP 1 catenin import into nucleus 1 P50148 362 2.30e-02 17 4 1 0.250 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 P29317 362 2.31e-02 29 4 1 0.250 0.034 REAC:977444 rea 1 GABA B receptor activation 1 P62879 362 2.31e-02 29 4 1 0.250 0.034 REAC:991365 rea 1 Activation of GABAB receptors 1 P62879 362 2.44e-02 18 4 1 0.250 0.056 GO:0061180 BP 1 mammary gland epithelium development 1 P29317 362 2.46e-02 31 4 1 0.250 0.032 REAC:163359 rea 1 Glucagon signaling in metabolic regulation 1 P62879 362 2.50e-02 385 4 2 0.500 0.005 GO:0001775 BP 1 cell activation 1 P29992,P50148 362 2.50e-02 3262 4 4 1.000 0.001 GO:0007154 BP 1 cell communication 1 P29992,P29317,P50148,P62879 362 2.52e-02 3268 4 4 1.000 0.001 GO:0044700 BP 1 single organism signaling 1 P29992,P29317,P50148,P62879 362 2.54e-02 3274 4 4 1.000 0.001 GO:0023052 BP 1 signaling 1 P29992,P29317,P50148,P62879 362 2.62e-02 1414 4 3 0.750 0.002 GO:0031090 CC 1 organelle membrane 1 P29992,P50148,P62879 362 2.70e-02 34 4 1 0.250 0.029 REAC:381676 rea 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 P62879 362 2.70e-02 1217 4 3 0.750 0.002 TF:M07226_1 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 1 P29992,P50148,P62879 362 2.71e-02 20 4 1 0.250 0.050 GO:0046849 BP 1 bone remodeling 1 P29317 362 2.78e-02 35 4 1 0.250 0.029 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 P62879 362 2.81e-02 409 4 2 0.500 0.005 GO:0044463 CC 1 cell projection part 1 P29992,P50148 362 2.84e-02 21 4 1 0.250 0.048 GO:0010863 BP 1 positive regulation of phospholipase C activity 1 P50148 362 2.86e-02 36 4 1 0.250 0.028 REAC:432040 rea 1 Vasopressin regulates renal water homeostasis via Aquaporins 1 P62879 362 2.86e-02 413 4 2 0.500 0.005 GO:0097458 CC 1 neuron part 1 P29992,P50148 362 2.88e-02 4447 4 4 1.000 0.001 HPA:026020_01 hpa 1 ovary; ovarian stroma cells[Uncertain,Low] 1 P29992,P29317,P50148,P62879 362 2.90e-02 3093 4 4 1.000 0.001 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 P29992,P29317,P50148,P62879 362 2.94e-02 37 4 1 0.250 0.027 REAC:6814122 rea 1 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1 P62879 362 2.94e-02 37 4 1 0.250 0.027 REAC:977443 rea 1 GABA receptor activation 1 P62879 362 2.98e-02 22 4 1 0.250 0.045 GO:0051898 BP 1 negative regulation of protein kinase B signaling 1 P29317 362 3.02e-02 38 4 1 0.250 0.026 REAC:397795 rea 1 G-protein beta:gamma signalling 1 P62879 362 3.02e-02 38 4 1 0.250 0.026 REAC:445717 rea 1 Aquaporin-mediated transport 1 P62879 362 3.09e-02 39 4 1 0.250 0.026 REAC:3928665 rea 1 EPH-ephrin mediated repulsion of cells 1 P29317 362 3.11e-02 1277 4 3 0.750 0.002 TF:M01820_0 tf 1 Factor: CREM; motif: TGACGTCASYN; match class: 0 1 P29317,P50148,P62879 362 3.11e-02 23 4 1 0.250 0.043 GO:0033628 BP 1 regulation of cell adhesion mediated by integrin 1 P29317 362 3.11e-02 23 4 1 0.250 0.043 GO:0090004 BP 1 positive regulation of establishment of protein localization to plasma membrane 1 P29317 362 3.21e-02 392 4 3 0.750 0.008 MI:hsa-miR-658 mi 1 MI:hsa-miR-658 1 P29992,P29317,P62879 362 3.25e-02 24 4 1 0.250 0.042 GO:1900274 BP 1 regulation of phospholipase C activity 1 P50148 362 3.33e-02 42 4 1 0.250 0.024 REAC:418597 rea 1 G alpha (z) signalling events 1 P62879 362 3.34e-02 2 4 1 0.250 0.500 CORUM:3153 cor 1 GNAQ-GEFT-RHOA complex 1 P50148 362 3.38e-02 25 4 1 0.250 0.040 GO:1904377 BP 1 positive regulation of protein localization to cell periphery 1 P29317 362 3.38e-02 25 4 1 0.250 0.040 GO:1903078 BP 1 positive regulation of protein localization to plasma membrane 1 P29317 362 3.57e-02 45 4 1 0.250 0.022 REAC:373080 rea 1 Class B/2 (Secretin family receptors) 1 P62879 362 3.64e-02 467 4 2 0.500 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 P29317,P50148 362 3.65e-02 27 4 1 0.250 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 P29317 362 3.65e-02 27 4 1 0.250 0.037 GO:0048593 BP 1 camera-type eye morphogenesis 1 P29317 362 3.77e-02 3302 4 4 1.000 0.001 TF:M07436_1 tf 1 Factor: WT1; motif: NNGGGNGGGSGN; match class: 1 1 P29992,P29317,P50148,P62879 362 3.79e-02 1607 4 3 0.750 0.002 GO:0016787 MF 1 hydrolase activity 1 P29992,P50148,P62879 362 3.79e-02 28 4 1 0.250 0.036 GO:0030879 BP 1 mammary gland development 1 P29317 362 3.79e-02 28 4 1 0.250 0.036 GO:0010518 BP 1 positive regulation of phospholipase activity 1 P50148 362 3.79e-02 28 4 1 0.250 0.036 GO:0030316 BP 1 osteoclast differentiation 1 P29317 362 3.82e-02 4774 4 4 1.000 0.001 HPA:041020_01 hpa 1 spleen; cells in white pulp[Uncertain,Low] 1 P29992,P29317,P50148,P62879 362 3.99e-02 257 4 2 0.500 0.008 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 P29317,P62879 362 4.04e-02 51 4 1 0.250 0.020 REAC:4086398 rea 1 Ca2+ pathway 1 P62879 362 4.19e-02 31 4 1 0.250 0.032 GO:0071377 BP 1 cellular response to glucagon stimulus 1 P62879 362 4.19e-02 31 4 1 0.250 0.032 GO:0030032 BP 1 lamellipodium assembly 1 P29317 362 4.19e-02 31 4 1 0.250 0.032 GO:0033627 BP 1 cell adhesion mediated by integrin 1 P29317 362 4.25e-02 506 4 2 0.500 0.004 GO:0051336 BP 1 regulation of hydrolase activity 1 P29317,P50148 362 4.32e-02 510 4 2 0.500 0.004 GO:0060341 BP 1 regulation of cellular localization 1 P29317,P50148 362 4.39e-02 3755 4 4 1.000 0.001 GO:0051716 BP 1 cellular response to stimulus 1 P29992,P29317,P50148,P62879 362 4.41e-02 3433 4 4 1.000 0.001 TF:M00915_0 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 0 1 P29992,P29317,P50148,P62879 362 4.46e-02 33 4 1 0.250 0.030 GO:0033762 BP 1 response to glucagon 1 P62879 362 4.47e-02 519 4 2 0.500 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 P29992,P50148 362 4.60e-02 34 4 1 0.250 0.029 GO:0060193 BP 1 positive regulation of lipase activity 1 P50148 362 4.73e-02 35 4 1 0.250 0.029 GO:0090003 BP 1 regulation of establishment of protein localization to plasma membrane 1 P29317 362 4.73e-02 35 4 1 0.250 0.029 GO:0010517 BP 1 regulation of phospholipase activity 1 P50148 362 4.82e-02 61 4 1 0.250 0.016 REAC:1296071 rea 1 Potassium Channels 1 P62879 362 4.87e-02 36 4 1 0.250 0.028 GO:0048754 BP 1 branching morphogenesis of an epithelial tube 1 P29317 362 4.89e-02 544 4 2 0.500 0.004 GO:0032880 BP 1 regulation of protein localization 1 P29317,P50148 362 4.97e-02 19 4 1 0.250 0.053 TF:M05621_0 tf 1 Factor: ZNF73; motif: NGTTACAACCGA; match class: 0 1 P50148 362 5.00e-02 1 4 1 0.250 1.000 OMIM:116600 omi 1 CATARACT 6, MULTIPLE TYPES; CTRCT6;;CATARACT, POSTERIOR POLAR, 1; CTPP1;;CATARACT, AGE-RELATED CORTICAL, 2; ARCC2 1 P29317 362 5.00e-02 3 4 1 0.250 0.333 CORUM:5190 cor 1 TIAM1-EFNB1-EPHA2 complex 1 P29317 362 5.00e-02 455 4 3 0.750 0.007 MI:hsa-miR-198 mi 1 MI:hsa-miR-198 1 P29317,P50148,P62879 362 5.00e-02 1503 4 3 0.750 0.002 TF:M00976_0 tf 1 Factor: AhR,; motif: NRCGTGNGN; match class: 0 1 P29317,P50148,P62879 362 5.00e-02 37 4 1 0.250 0.027 GO:0043535 BP 1 regulation of blood vessel endothelial cell migration 1 P29317 362 5.00e-02 15 4 2 0.500 0.133 HP:0001139 hp 1 Choroideremia 1 P29317,P50148 362 5.00e-02 23 4 1 0.250 0.043 KEGG:05143 keg 1 African trypanosomiasis 1 P50148 362 5.00e-02 1 4 1 0.250 1.000 OMIM:615361 omi 1 HYPOCALCEMIA, AUTOSOMAL DOMINANT 2; HYPOC2 1 P29992 362 5.00e-02 1575 4 3 0.750 0.002 REAC:162582 rea 1 Signal Transduction 1 P29992,P50148,P62879 362 5.00e-02 1 4 1 0.250 1.000 OMIM:163000 omi 1 CAPILLARY MALFORMATIONS, CONGENITAL; CMC;;NEVI FLAMMEI, FAMILIAL MULTIPLE;;PORT-WINE STAIN;;CAPILLARY MALFORMATIONS; CMAL 1 P50148 362 5.00e-02 3 4 1 0.250 0.333 CORUM:557 cor 1 TRP1-G alpha-11-IP3R3-CAV1 signaling complex 1 P29992 362 5.00e-02 1 4 1 0.250 1.000 OMIM:145981 omi 1 HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II; HHC2;;FAMILIAL BENIGN HYPERCALCEMIA, TYPE II; FBH2;;HYPERCALCEMIA, FAMILIAL BENIGN, TYPE II 1 P29992 362 5.00e-02 1 4 1 0.250 1.000 OMIM:185300 omi 1 STURGE-WEBER SYNDROME; SWS 1 P50148 363 2.23e-03 601 2 2 1.000 0.003 TF:M00510_0 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 0 1 Q7LGA3,Q9BRR3 363 2.88e-03 684 2 2 1.000 0.003 TF:M00011_0 tf 1 Factor: Evi-1; motif: ACAAGATAA; match class: 0 1 Q7LGA3,Q9BRR3 363 4.17e-03 1 2 1 0.500 1.000 GO:0004394 MF 1 heparan sulfate 2-O-sulfotransferase activity 1 Q7LGA3 363 5.65e-03 36 2 1 0.500 0.028 TF:M04161_0 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 0 1 Q7LGA3 363 5.65e-03 36 2 1 0.500 0.028 TF:M04161_1 tf 1 Factor: BHLHA15; motif: ACCATATGGT; match class: 1 1 Q7LGA3 363 5.81e-03 37 2 1 0.500 0.027 TF:M05993_0 tf 1 Factor: ZNF711; motif: NTGCGTGCGC; match class: 0 1 Q7LGA3 363 6.43e-03 41 2 1 0.500 0.024 TF:M05350_0 tf 1 Factor: OZF; motif: KGTTAAAGGARA; match class: 0 1 Q7LGA3 363 7.00e-03 1065 2 2 1.000 0.002 TF:M01971_0 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 0 1 Q7LGA3,Q9BRR3 363 1.03e-02 1291 2 2 1.000 0.002 TF:M00071_0 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 0 1 Q7LGA3,Q9BRR3 363 1.07e-02 68 2 1 0.500 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q7LGA3 363 1.18e-02 1175 2 2 1.000 0.002 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q7LGA3,Q9BRR3 363 1.41e-02 28 2 1 0.500 0.036 REAC:2022928 rea 1 HS-GAG biosynthesis 1 Q7LGA3 363 1.41e-02 90 2 1 0.500 0.011 TF:M06038_0 tf 1 Factor: TCF17; motif: NGKGGAAWAAKM; match class: 0 1 Q7LGA3 363 1.47e-02 1310 2 2 1.000 0.002 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 Q7LGA3,Q9BRR3 363 1.71e-02 109 2 1 0.500 0.009 TF:M04002_1 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 1 1 Q9BRR3 363 1.74e-02 111 2 1 0.500 0.009 TF:M04000_0 tf 1 Factor: GCM1; motif: ATRCKGGTRCCMGCAN; match class: 0 1 Q9BRR3 363 1.86e-02 1737 2 2 1.000 0.001 TF:M00350_1 tf 1 Factor: GATA-3; motif: NGAGATAANA; match class: 1 1 Q7LGA3,Q9BRR3 363 2.09e-02 134 2 1 0.500 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 Q9BRR3 363 2.30e-02 147 2 1 0.500 0.007 TF:M05926_0 tf 1 Factor: ZNF700; motif: NACKACTAGTSN; match class: 0 1 Q9BRR3 363 2.31e-02 46 2 1 0.500 0.022 REAC:1638091 rea 1 Heparan sulfate/heparin (HS-GAG) metabolism 1 Q7LGA3 363 2.45e-02 157 2 1 0.500 0.006 TF:M03824_1 tf 1 Factor: GCMb; motif: RCCCKCAT; match class: 1 1 Q9BRR3 363 2.49e-02 2008 2 2 1.000 0.001 TF:M04442_1 tf 1 Factor: UNCX; motif: NTAATNNAATTAN; match class: 1 1 Q7LGA3,Q9BRR3 363 2.59e-02 2047 2 2 1.000 0.001 TF:M01816_0 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 0 1 Q7LGA3,Q9BRR3 363 3.13e-02 2251 2 2 1.000 0.001 TF:M06887_0 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 0 1 Q7LGA3,Q9BRR3 363 3.15e-02 202 2 1 0.500 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 Q9BRR3 363 3.37e-02 216 2 1 0.500 0.005 TF:M04190_0 tf 1 Factor: TCF3; motif: NRCACCTGNN; match class: 0 1 Q9BRR3 363 3.37e-02 2337 2 2 1.000 0.001 TF:M04414_0 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 0 1 Q7LGA3,Q9BRR3 363 3.40e-02 218 2 1 0.500 0.005 TF:M07139_0 tf 1 Factor: USF2; motif: RYCAYGTGACY; match class: 0 1 Q9BRR3 363 3.47e-02 2370 2 2 1.000 0.001 TF:M04624_0 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 0 1 Q7LGA3,Q9BRR3 363 3.52e-02 226 2 1 0.500 0.004 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q9BRR3 363 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q7LGA3,Q9BRR3 363 3.72e-02 239 2 1 0.500 0.004 TF:M04186_0 tf 1 Factor: OLIG2; motif: AMCATATGKT; match class: 0 1 Q7LGA3 363 3.72e-02 239 2 1 0.500 0.004 TF:M04186_1 tf 1 Factor: OLIG2; motif: AMCATATGKT; match class: 1 1 Q7LGA3 363 3.73e-02 2459 2 2 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q7LGA3,Q9BRR3 363 4.06e-02 261 2 1 0.500 0.004 TF:M04187_1 tf 1 Factor: OLIG3; motif: AMCATATGNY; match class: 1 1 Q7LGA3 363 4.26e-02 2628 2 2 1.000 0.001 TF:M04393_1 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 1 1 Q7LGA3,Q9BRR3 363 4.31e-02 2644 2 2 1.000 0.001 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 Q7LGA3,Q9BRR3 363 4.32e-02 278 2 1 0.500 0.004 TF:M07363_0 tf 1 Factor: NF-1; motif: NNNGCCAANN; match class: 0 1 Q7LGA3 363 4.32e-02 2647 2 2 1.000 0.001 TF:M04343_0 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 0 1 Q7LGA3,Q9BRR3 363 4.44e-02 286 2 1 0.500 0.003 TF:M04414_1 tf 1 Factor: NKX3-2; motif: NCCACTTAA; match class: 1 1 Q7LGA3 363 4.46e-02 2689 2 2 1.000 0.001 TF:M04144_0 tf 1 Factor: TEAD3; motif: RCATTCCW; match class: 0 1 Q7LGA3,Q9BRR3 363 4.54e-02 292 2 1 0.500 0.003 TF:M04259_1 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 1 1 Q9BRR3 363 4.54e-02 292 2 1 0.500 0.003 TF:M04247_1 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 1 1 Q9BRR3 363 4.54e-02 292 2 1 0.500 0.003 TF:M04255_1 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 1 1 Q9BRR3 363 4.55e-02 2714 2 2 1.000 0.001 TF:M04413_0 tf 1 Factor: NKX3-1; motif: NCCACTTAA; match class: 0 1 Q7LGA3,Q9BRR3 363 4.57e-02 294 2 1 0.500 0.003 TF:M01739_1 tf 1 Factor: TFIIB; motif: SASTATRWAAG; match class: 1 1 Q9BRR3 363 4.74e-02 305 2 1 0.500 0.003 TF:M00930_1 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 1 1 Q9BRR3 363 4.86e-02 313 2 1 0.500 0.003 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 Q7LGA3 363 4.96e-02 281 2 1 0.500 0.004 MI:hsa-miR-144* mi 1 MI:hsa-miR-144* 1 Q7LGA3 363 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 Q9BRR3 363 5.00e-02 2846 2 2 1.000 0.001 TF:M04392_1 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 1 1 Q7LGA3,Q9BRR3 363 5.00e-02 12 2 1 0.500 0.083 GO:0034483 MF 1 heparan sulfate sulfotransferase activity 1 Q7LGA3 363 5.00e-02 100 2 1 0.500 0.010 REAC:1630316 rea 1 Glycosaminoglycan metabolism 1 Q7LGA3 363 5.00e-02 22 2 1 0.500 0.045 KEGG:00534 keg 1 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 Q7LGA3 364 3.80e-02 38 3 1 0.333 0.026 GO:0005070 MF 1 SH3/SH2 adaptor activity 1 Q14847 364 4.10e-02 41 3 1 0.333 0.024 GO:0030864 CC 1 cortical actin cytoskeleton 1 Q14847 364 4.47e-02 8 3 1 0.333 0.125 TF:M04062_0 tf 1 Factor: PAX3; motif: TAATYRATTA; match class: 0 1 Q92576 364 4.47e-02 8 3 1 0.333 0.125 TF:M04066_0 tf 1 Factor: PAX7; motif: TAATCGATTA; match class: 0 1 Q92576 364 4.47e-02 8 3 1 0.333 0.125 TF:M04066_1 tf 1 Factor: PAX7; motif: TAATCGATTA; match class: 1 1 Q92576 364 4.47e-02 8 3 1 0.333 0.125 TF:M04062_1 tf 1 Factor: PAX3; motif: TAATYRATTA; match class: 1 1 Q92576 364 4.63e-02 1403 3 2 0.667 0.001 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q14847,Q92576 364 5.00e-02 1633 3 3 1.000 0.002 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 Q14847,Q92576,Q9BZF9 364 5.00e-02 50 3 1 0.333 0.020 GO:0030863 CC 1 cortical cytoskeleton 1 Q14847 365 1.54e-02 794 3 2 0.667 0.003 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 P52739,A1XBS5 365 1.58e-02 803 3 2 0.667 0.002 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 P52739,A1XBS5 365 1.67e-02 1 3 1 0.333 1.000 GO:0007231 BP 1 osmosensory signaling pathway 1 Q9NS73 365 1.67e-02 1 3 1 0.333 1.000 GO:0000173 BP 1 inactivation of MAPK activity involved in osmosensory signaling pathway 1 Q9NS73 365 1.72e-02 840 3 2 0.667 0.002 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 P52739,A1XBS5 365 2.70e-02 340 3 2 0.667 0.006 MI:mmu-miR-694 mi 1 MI:mmu-miR-694 1 Q9NS73,A1XBS5 365 3.73e-02 1254 3 2 0.667 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 P52739,A1XBS5 365 3.81e-02 93 3 1 0.333 0.011 REAC:3214847 rea 1 HATs acetylate histones 1 Q9NS73 365 4.28e-02 429 3 2 0.667 0.005 MI:hsa-miR-30e* mi 1 MI:hsa-miR-30e* 1 Q9NS73,A1XBS5 365 4.41e-02 1369 3 2 0.667 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 P52739,A1XBS5 365 4.64e-02 447 3 2 0.667 0.004 MI:hsa-miR-517a mi 1 MI:hsa-miR-517a 1 Q9NS73,P52739 365 4.71e-02 450 3 2 0.667 0.004 MI:hsa-miR-586 mi 1 MI:hsa-miR-586 1 Q9NS73,P52739 365 4.71e-02 3899 3 3 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q9NS73,P52739,A1XBS5 365 5.00e-02 3 3 1 0.333 0.333 GO:0047484 BP 1 regulation of response to osmotic stress 1 Q9NS73 365 5.00e-02 1082 3 3 1.000 0.003 TF:M07278_1 tf 1 Factor: Dlx3; motif: NTAATTNVN; match class: 1 1 Q9NS73,P52739,A1XBS5 365 5.00e-02 464 3 2 0.667 0.004 MI:hsa-miR-30a* mi 1 MI:hsa-miR-30a* 1 Q9NS73,A1XBS5 365 5.00e-02 464 3 2 0.667 0.004 MI:hsa-miR-517c mi 1 MI:hsa-miR-517c 1 Q9NS73,P52739 366 3.77e-03 24 2 1 0.500 0.042 TF:M04471_1 tf 1 Factor: NR2E1; motif: AAGTCAANAAGTCA; match class: 1 1 Q5TDH0 366 4.45e-03 850 2 2 1.000 0.002 TF:M04333_1 tf 1 Factor: HMX1; motif: ANCAATTAANN; match class: 1 1 Q9UJA5,Q5TDH0 366 7.76e-03 1122 2 2 1.000 0.002 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 Q9UJA5,Q5TDH0 366 8.31e-03 53 2 1 0.500 0.019 TF:M05325_0 tf 1 Factor: Tbx3; motif: AGGTGTGAAAT; match class: 0 1 Q5TDH0 366 8.31e-03 53 2 1 0.500 0.019 TF:M05365_0 tf 1 Factor: TBX2; motif: AGGTGTGAAAT; match class: 0 1 Q5TDH0 366 8.71e-03 1188 2 2 1.000 0.002 TF:M01968_1 tf 1 Factor: FOXO1; motif: TGTTKAC; match class: 1 1 Q9UJA5,Q5TDH0 366 9.17e-03 1219 2 2 1.000 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q9UJA5,Q5TDH0 366 9.29e-03 1227 2 2 1.000 0.002 TF:M07314_0 tf 1 Factor: Blimp-1; motif: CTTTCNCTTYCY; match class: 0 1 Q9UJA5,Q5TDH0 366 1.07e-02 68 2 1 0.500 0.015 TF:M03832_1 tf 1 Factor: Net; motif: CACTTCCKGK; match class: 1 1 Q5TDH0 366 1.29e-02 1444 2 2 1.000 0.001 TF:M07089_0 tf 1 Factor: Fli-1; motif: RCAGGAAGTGR; match class: 0 1 Q9UJA5,Q5TDH0 366 1.30e-02 1451 2 2 1.000 0.001 TF:M07417_0 tf 1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 0 1 Q9UJA5,Q5TDH0 366 1.38e-02 88 2 1 0.500 0.011 TF:M04120_0 tf 1 Factor: TBR1; motif: AAGGTGTGAAA; match class: 0 1 Q5TDH0 366 1.39e-02 1502 2 2 1.000 0.001 TF:M00763_0 tf 1 Factor: PPAR; motif: TGACCTTTGNCCY; match class: 0 1 Q9UJA5,Q5TDH0 366 1.39e-02 89 2 1 0.500 0.011 TF:M06132_0 tf 1 Factor: ZNF823; motif: NYYACCAGCCCT; match class: 0 1 Q9UJA5 366 1.59e-02 1603 2 2 1.000 0.001 TF:M02055_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q9UJA5,Q5TDH0 366 1.59e-02 1603 2 2 1.000 0.001 TF:M01214_1 tf 1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 1 Q9UJA5,Q5TDH0 366 1.61e-02 103 2 1 0.500 0.010 TF:M03985_1 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 1 1 Q5TDH0 366 1.63e-02 104 2 1 0.500 0.010 TF:M05700_0 tf 1 Factor: ZNF19; motif: KGGGGCTGCTGC; match class: 0 1 Q5TDH0 366 1.63e-02 1380 2 2 1.000 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q9UJA5,Q5TDH0 366 1.67e-02 107 2 1 0.500 0.009 TF:M03946_0 tf 1 Factor: GRHL1; motif: AACCGGTNNAACCGGTT; match class: 0 1 Q5TDH0 366 1.90e-02 1757 2 2 1.000 0.001 TF:M02056_1 tf 1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 1 Q9UJA5,Q5TDH0 366 2.05e-02 131 2 1 0.500 0.008 TF:M03931_0 tf 1 Factor: ZIC3; motif: GACCCCCCGCTGYGN; match class: 0 1 Q5TDH0 366 2.13e-02 136 2 1 0.500 0.007 TF:M01002_1 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 1 1 Q9UJA5 366 2.19e-02 140 2 1 0.500 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q5TDH0 366 2.19e-02 1884 2 2 1.000 0.001 TF:M01248_0 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 0 1 Q9UJA5,Q5TDH0 366 2.28e-02 1921 2 2 1.000 0.001 TF:M01117_0 tf 1 Factor: OTX; motif: GATTANNT; match class: 0 1 Q9UJA5,Q5TDH0 366 2.35e-02 1951 2 2 1.000 0.001 TF:M01267_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 Q9UJA5,Q5TDH0 366 2.35e-02 1951 2 2 1.000 0.001 TF:M00926_0 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 0 1 Q9UJA5,Q5TDH0 366 2.59e-02 2049 2 2 1.000 0.001 TF:M01876_0 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 0 1 Q9UJA5,Q5TDH0 366 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 Q9UJA5,Q5TDH0 366 2.92e-02 60 2 1 0.500 0.017 GO:0006400 BP 1 tRNA modification 1 Q9UJA5 366 3.13e-02 2251 2 2 1.000 0.001 TF:M06887_0 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 0 1 Q9UJA5,Q5TDH0 366 3.16e-02 203 2 1 0.500 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 Q9UJA5 366 3.26e-02 2299 2 2 1.000 0.001 TF:M02061_0 tf 1 Factor: ERF; motif: ACCGGAARYN; match class: 0 1 Q9UJA5,Q5TDH0 366 3.28e-02 2305 2 2 1.000 0.001 TF:M00289_1 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 1 Q9UJA5,Q5TDH0 366 3.45e-02 2365 2 2 1.000 0.001 TF:M00925_0 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 0 1 Q9UJA5,Q5TDH0 366 3.47e-02 223 2 1 0.500 0.004 TF:M06677_0 tf 1 Factor: ZNF285; motif: NGTTCMKAAAGM; match class: 0 1 Q5TDH0 366 3.57e-02 229 2 1 0.500 0.004 TF:M07256_1 tf 1 Factor: FXR:RXR; motif: RGGTCANTGACCTN; match class: 1 1 Q9UJA5 366 3.83e-02 2492 2 2 1.000 0.001 TF:M05347_0 tf 1 Factor: TR2; motif: NAGGTCAA; match class: 0 1 Q9UJA5,Q5TDH0 366 3.85e-02 2497 2 2 1.000 0.001 TF:M00678_0 tf 1 Factor: Tel-2; motif: YTACTTCCTG; match class: 0 1 Q9UJA5,Q5TDH0 366 3.92e-02 252 2 1 0.500 0.004 TF:M03883_1 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 1 1 Q9UJA5 366 3.95e-02 254 2 1 0.500 0.004 TF:M01876_1 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 1 1 Q5TDH0 366 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q9UJA5 366 4.15e-02 267 2 1 0.500 0.004 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 Q5TDH0 366 4.15e-02 267 2 1 0.500 0.004 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 Q5TDH0 366 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 Q5TDH0 366 4.23e-02 2617 2 2 1.000 0.001 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 Q9UJA5,Q5TDH0 366 4.34e-02 279 2 1 0.500 0.004 TF:M04290_0 tf 1 Factor: BARX1; motif: CNATTAAAWANCNATTA; match class: 0 1 Q9UJA5 366 4.42e-02 91 2 1 0.500 0.011 GO:0008033 BP 1 tRNA processing 1 Q9UJA5 366 4.48e-02 2695 2 2 1.000 0.001 TF:M01258_0 tf 1 Factor: GABP; motif: CACTTCCGGNNN; match class: 0 1 Q9UJA5,Q5TDH0 366 4.51e-02 2702 2 2 1.000 0.001 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 Q9UJA5,Q5TDH0 366 4.52e-02 291 2 1 0.500 0.003 TF:M00436_1 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 1 1 Q5TDH0 366 4.53e-02 2710 2 2 1.000 0.001 TF:M03794_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q9UJA5,Q5TDH0 366 4.53e-02 2710 2 2 1.000 0.001 TF:M02019_1 tf 1 Factor: LEF-1; motif: WCAAAGN; match class: 1 1 Q9UJA5,Q5TDH0 366 4.54e-02 2712 2 2 1.000 0.001 TF:M00771_0 tf 1 Factor: Ets; motif: ANNCACTTCCTG; match class: 0 1 Q9UJA5,Q5TDH0 366 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 Q5TDH0 366 4.78e-02 308 2 1 0.500 0.003 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 Q5TDH0 366 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q9UJA5,Q5TDH0 366 4.87e-02 276 2 1 0.500 0.004 MI:hsa-miR-96* mi 1 MI:hsa-miR-96* 1 Q5TDH0 366 4.94e-02 280 2 1 0.500 0.004 MI:hsa-miR-335* mi 1 MI:hsa-miR-335* 1 Q5TDH0 366 5.00e-02 322 2 1 0.500 0.003 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q5TDH0 366 5.00e-02 41 2 1 0.500 0.024 REAC:6782315 rea 1 tRNA modification in the nucleus and cytosol 1 Q9UJA5 366 5.00e-02 103 2 1 0.500 0.010 GO:0009451 BP 1 RNA modification 1 Q9UJA5 367 9.43e-04 3 4 1 0.250 0.333 TF:M05774_0 tf 1 Factor: ZNF697; motif: KGGTACGAGGGM; match class: 0 1 Q15649 367 2.03e-03 1 4 1 0.250 1.000 OMIM:615490 omi 1 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R; CMT2R;;CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 2R;;CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL RECESSIVE, TYPE 2R 1 Q9C040 367 2.20e-03 7 4 1 0.250 0.143 TF:M00023_1 tf 1 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN; match class: 1 1 Q9C040 367 3.14e-03 10 4 1 0.250 0.100 TF:M04498_0 tf 1 Factor: VDR; motif: GRGTTCATYGRGTTCA; match class: 0 1 P63215 367 3.25e-03 1219 4 3 0.750 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 Q9C040,P63215,Q15649 367 6.18e-03 1519 4 3 0.750 0.002 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 7.37e-03 1614 4 3 0.750 0.002 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 8.77e-03 28 4 1 0.250 0.036 TF:M06695_0 tf 1 Factor: ZNF160; motif: CTAAATCCGC; match class: 0 1 Q9C040 367 1.10e-02 1856 4 3 0.750 0.002 TF:M04425_0 tf 1 Factor: PDX1; motif: NYAATTAN; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 1.10e-02 1856 4 3 0.750 0.002 TF:M04316_0 tf 1 Factor: EN1; motif: NYAATTAN; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 1.13e-02 36 4 1 0.250 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 Q9C040 367 1.38e-02 44 4 1 0.250 0.023 TF:M04406_0 tf 1 Factor: MSX2; motif: GCAATTAAAWWSCAATTA; match class: 0 1 Q15649 367 1.41e-02 45 4 1 0.250 0.022 TF:M06367_0 tf 1 Factor: ZNF530; motif: KGGGGAAAAAKA; match class: 0 1 P63215 367 1.44e-02 46 4 1 0.250 0.022 TF:M05482_0 tf 1 Factor: ZFP202; motif: NGGGGCGAAT; match class: 0 1 Q15649 367 1.50e-02 48 4 1 0.250 0.021 TF:M06308_1 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 1 1 Q9C040 367 1.53e-02 49 4 1 0.250 0.020 TF:M03995_0 tf 1 Factor: SPIB; motif: NAAAAGMGGAAGTN; match class: 0 1 Q9C040 367 1.61e-02 684 4 2 0.500 0.003 TF:M01591_1 tf 1 Factor: Tal-1; motif: CTTCCTTMTCTSY; match class: 1 1 Q9C040,P63215 367 1.74e-02 4622 4 4 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 Q9UHK0,Q9C040,P63215,Q15649 367 1.80e-02 15 4 1 0.250 0.067 REAC:1296041 rea 1 Activation of G protein gated Potassium channels 1 P63215 367 1.80e-02 15 4 1 0.250 0.067 REAC:1296059 rea 1 G protein gated Potassium channels 1 P63215 367 1.80e-02 15 4 1 0.250 0.067 REAC:997272 rea 1 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 1 P63215 367 1.80e-02 4666 4 4 1.000 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 Q9UHK0,Q9C040,P63215,Q15649 367 1.83e-02 731 4 2 0.500 0.003 TF:M04309_0 tf 1 Factor: DUXA; motif: NTRAYYTAATCAN; match class: 0 1 Q9C040,Q15649 367 1.92e-02 16 4 1 0.250 0.062 REAC:392851 rea 1 Prostacyclin signalling through prostacyclin receptor 1 P63215 367 2.01e-02 2288 4 3 0.750 0.001 TF:M00233_0 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 2.03e-02 17 4 1 0.250 0.059 REAC:420092 rea 1 Glucagon-type ligand receptors 1 P63215 367 2.15e-02 18 4 1 0.250 0.056 REAC:418217 rea 1 G beta:gamma signalling through PLC beta 1 P63215 367 2.24e-02 72 4 1 0.250 0.014 TF:M06225_0 tf 1 Factor: ZNF271; motif: NGGTCMAGACGM; match class: 0 1 Q15649 367 2.27e-02 19 4 1 0.250 0.053 REAC:500657 rea 1 Presynaptic function of Kainate receptors 1 P63215 367 2.27e-02 19 4 1 0.250 0.053 REAC:428930 rea 1 Thromboxane signalling through TP receptor 1 P63215 367 2.34e-02 2416 4 3 0.750 0.001 TF:M00965_0 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 0 1 Q9UHK0,Q9C040,P63215 367 2.39e-02 20 4 1 0.250 0.050 REAC:418592 rea 1 ADP signalling through P2Y purinoceptor 1 1 P63215 367 2.39e-02 20 4 1 0.250 0.050 REAC:1296065 rea 1 Inwardly rectifying K+ channels 1 P63215 367 2.39e-02 20 4 1 0.250 0.050 REAC:392170 rea 1 ADP signalling through P2Y purinoceptor 12 1 P63215 367 2.67e-02 5147 4 4 1.000 0.001 TF:M00630_0 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 0 1 Q9UHK0,Q9C040,P63215,Q15649 367 2.71e-02 87 4 1 0.250 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 P63215 367 2.75e-02 23 4 1 0.250 0.043 REAC:202040 rea 1 G-protein activation 1 P63215 367 2.92e-02 94 4 1 0.250 0.011 TF:M06284_0 tf 1 Factor: Cos52; motif: NNGTSSTAAAGC; match class: 0 1 Q15649 367 2.99e-02 25 4 1 0.250 0.040 REAC:400042 rea 1 Adrenaline,noradrenaline inhibits insulin secretion 1 P63215 367 2.99e-02 25 4 1 0.250 0.040 REAC:456926 rea 1 Thrombin signalling through proteinase activated receptors (PARs) 1 P63215 367 3.01e-02 97 4 1 0.250 0.010 TF:M04386_0 tf 1 Factor: LHX2; motif: YAATTANNCTAATTR; match class: 0 1 Q15649 367 3.04e-02 98 4 1 0.250 0.010 TF:M03947_1 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 1 1 Q9UHK0 367 3.12e-02 5351 4 4 1.000 0.001 TF:M00126_1 tf 1 Factor: GATA-1; motif: NNNNNGATANKGGN; match class: 1 1 Q9UHK0,Q9C040,P63215,Q15649 367 3.22e-02 27 4 1 0.250 0.037 REAC:392518 rea 1 Signal amplification 1 P63215 367 3.22e-02 27 4 1 0.250 0.037 REAC:451326 rea 1 Activation of Kainate Receptors upon glutamate binding 1 P63215 367 3.44e-02 111 4 1 0.250 0.009 TF:M06003_0 tf 1 Factor: ZNF257; motif: NTGGWGGGCAKM; match class: 0 1 Q9UHK0 367 3.46e-02 29 4 1 0.250 0.034 REAC:977444 rea 1 GABA B receptor activation 1 P63215 367 3.46e-02 29 4 1 0.250 0.034 REAC:991365 rea 1 Activation of GABAB receptors 1 P63215 367 3.54e-02 5521 4 4 1.000 0.001 TF:M02220_0 tf 1 Factor: HNF4A; motif: RGGNCAAAGKYCA; match class: 0 1 Q9UHK0,Q9C040,P63215,Q15649 367 3.57e-02 115 4 1 0.250 0.009 TF:M03947_0 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 0 1 Q9UHK0 367 3.58e-02 1040 4 2 0.500 0.002 TF:M05882_0 tf 1 Factor: ZNF709; motif: NGRWCCAYAAGA; match class: 0 1 Q9UHK0,Q15649 367 3.58e-02 2808 4 3 0.750 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 Q9UHK0,Q9C040,P63215 367 3.60e-02 2813 4 3 0.750 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 3.70e-02 31 4 1 0.250 0.032 REAC:163359 rea 1 Glucagon signaling in metabolic regulation 1 P63215 367 3.71e-02 1060 4 2 0.500 0.002 TF:M03921_1 tf 1 Factor: SP3; motif: NCCACGCCCMC; match class: 1 1 Q9C040,Q15649 367 4.05e-02 2935 4 3 0.750 0.001 TF:M01889_1 tf 1 Factor: Smad4; motif: TGTCTGN; match class: 1 1 Q9C040,P63215,Q15649 367 4.05e-02 131 4 1 0.250 0.008 TF:M03931_0 tf 1 Factor: ZIC3; motif: GACCCCCCGCTGYGN; match class: 0 1 Q9C040 367 4.05e-02 34 4 1 0.250 0.029 REAC:381676 rea 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 P63215 367 4.12e-02 2952 4 3 0.750 0.001 TF:M00454_0 tf 1 Factor: MRF2; motif: AWSCACAATACNVA; match class: 0 1 Q9UHK0,Q9C040,Q15649 367 4.17e-02 35 4 1 0.250 0.029 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 P63215 367 4.18e-02 135 4 1 0.250 0.007 TF:M03904_0 tf 1 Factor: GLIS2; motif: GACCCCCCGCRANG; match class: 0 1 Q9C040 367 4.24e-02 2983 4 3 0.750 0.001 TF:M03554_1 tf 1 Factor: NF-1A; motif: NGCCARN; match class: 1 1 Q9C040,P63215,Q15649 367 4.29e-02 36 4 1 0.250 0.028 REAC:432040 rea 1 Vasopressin regulates renal water homeostasis via Aquaporins 1 P63215 367 4.33e-02 140 4 1 0.250 0.007 TF:M00437_0 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 0 1 Q15649 367 4.41e-02 37 4 1 0.250 0.027 REAC:977443 rea 1 GABA receptor activation 1 P63215 367 4.41e-02 37 4 1 0.250 0.027 REAC:6814122 rea 1 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1 P63215 367 4.46e-02 5849 4 4 1.000 0.001 TF:M00644_1 tf 1 Factor: LBP-1; motif: CAGCTGS; match class: 1 1 Q9UHK0,Q9C040,P63215,Q15649 367 4.48e-02 145 4 1 0.250 0.007 TF:M07264_1 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 1 1 Q9UHK0 367 4.53e-02 38 4 1 0.250 0.026 REAC:445717 rea 1 Aquaporin-mediated transport 1 P63215 367 4.53e-02 38 4 1 0.250 0.026 REAC:397795 rea 1 G-protein beta:gamma signalling 1 P63215 367 4.63e-02 150 4 1 0.250 0.007 TF:M01783_1 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 1 1 P63215 367 4.76e-02 3109 4 3 0.750 0.001 TF:M00809_1 tf 1 Factor: FOX; motif: KWTTGTTTRTTTW; match class: 1 1 Q9UHK0,Q9C040,Q15649 367 4.84e-02 157 4 1 0.250 0.006 TF:M04404_0 tf 1 Factor: MSX1; motif: NCAATTAAANNSCAATTA; match class: 0 1 Q15649 367 5.00e-02 25 4 1 0.250 0.040 OMIM:118210 omi 1 Charcot-Marie-Tooth Disease Type 2 1 Q9C040 367 5.00e-02 42 4 1 0.250 0.024 REAC:418597 rea 1 G alpha (z) signalling events 1 P63215 367 5.00e-02 1 4 1 0.250 1.000 GO:0005726 CC 1 perichromatin fibrils 1 Q9UHK0 367 5.00e-02 22 4 1 0.250 0.045 HP:0002136 hp 1 Broad-based gait 1 Q9C040 368 2.70e-04 27 4 2 0.500 0.074 REAC:6803529 rea 1 FGFR2 alternative splicing 1 P31483,Q01085 368 3.55e-04 31 4 2 0.500 0.065 GO:0010494 CC 1 cytoplasmic stress granule 1 P31483,Q01085 368 1.78e-03 69 4 2 0.500 0.029 GO:0008543 BP 1 fibroblast growth factor receptor signaling pathway 1 P31483,Q01085 368 2.28e-03 78 4 2 0.500 0.026 GO:0044344 BP 1 cellular response to fibroblast growth factor stimulus 1 P31483,Q01085 368 2.40e-03 80 4 2 0.500 0.025 GO:0071774 BP 1 response to fibroblast growth factor 1 P31483,Q01085 368 2.95e-03 1 4 1 0.250 1.000 GO:0035730 MF 1 S-nitrosoglutathione binding 1 P09211 368 2.95e-03 1 4 1 0.250 1.000 GO:0035731 MF 1 dinitrosyl-iron complex binding 1 P09211 368 2.95e-03 1 4 1 0.250 1.000 GO:0035732 BP 1 nitric oxide storage 1 P09211 368 2.95e-03 1 4 1 0.250 1.000 GO:0035726 BP 1 common myeloid progenitor cell proliferation 1 P09211 368 4.87e-03 114 4 2 0.500 0.018 GO:0036464 CC 1 cytoplasmic ribonucleoprotein granule 1 P31483,Q01085 368 5.40e-03 120 4 2 0.500 0.017 GO:0035770 CC 1 ribonucleoprotein granule 1 P31483,Q01085 368 5.89e-03 2 4 1 0.250 0.500 GO:0097165 CC 1 nuclear stress granule 1 P31483 368 5.89e-03 2 4 1 0.250 0.500 GO:0070026 MF 1 nitric oxide binding 1 P09211 368 5.89e-03 2 4 1 0.250 0.500 GO:0097057 CC 1 TRAF2-GSTP1 complex 1 P09211 368 5.89e-03 2 4 1 0.250 0.500 GO:0033484 BP 1 nitric oxide homeostasis 1 P09211 368 5.89e-03 2 4 1 0.250 0.500 GO:0051771 BP 1 negative regulation of nitric-oxide synthase biosynthetic process 1 P09211 368 8.84e-03 3 4 1 0.250 0.333 GO:0071638 BP 1 negative regulation of monocyte chemotactic protein-1 production 1 P09211 368 8.84e-03 3 4 1 0.250 0.333 GO:0002674 BP 1 negative regulation of acute inflammatory response 1 P09211 368 1.47e-02 5 4 1 0.250 0.200 GO:0008432 MF 1 JUN kinase binding 1 P09211 368 1.47e-02 5 4 1 0.250 0.200 GO:0071637 BP 1 regulation of monocyte chemotactic protein-1 production 1 P09211 368 1.47e-02 5 4 1 0.250 0.200 GO:0032691 BP 1 negative regulation of interleukin-1 beta production 1 P09211 368 1.47e-02 5 4 1 0.250 0.200 GO:0071605 BP 1 monocyte chemotactic protein-1 production 1 P09211 368 1.47e-02 5 4 1 0.250 0.200 GO:0032930 BP 1 positive regulation of superoxide anion generation 1 P09211 368 1.67e-02 1 4 1 0.250 1.000 OMIM:604454 omi 1 WELANDER DISTAL MYOPATHY; WDM;;MUSCULAR DYSTROPHY, DISTAL, LATE-ONSET, AUTOSOMAL DOMINANT;;MYOPATHY, DISTAL, SWEDISH 1 P31483 368 1.70e-02 936 4 3 0.750 0.003 GO:0006915 BP 1 apoptotic process 1 P09211,P31483,Q01085 368 1.81e-02 956 4 3 0.750 0.003 GO:0012501 BP 1 programmed cell death 1 P09211,P31483,Q01085 368 2.06e-02 7 4 1 0.250 0.143 GO:1903608 BP 1 protein localization to cytoplasmic stress granule 1 P31483 368 2.06e-02 7 4 1 0.250 0.143 GO:0032692 BP 1 negative regulation of interleukin-1 production 1 P09211 368 2.06e-02 7 4 1 0.250 0.143 GO:0032928 BP 1 regulation of superoxide anion generation 1 P09211 368 2.25e-02 1029 4 3 0.750 0.003 GO:0008219 BP 1 cell death 1 P09211,P31483,Q01085 368 2.36e-02 8 4 1 0.250 0.125 GO:0043508 BP 1 negative regulation of JUN kinase activity 1 P09211 368 2.36e-02 8 4 1 0.250 0.125 GO:0033483 BP 1 gas homeostasis 1 P09211 368 2.36e-02 8 4 1 0.250 0.125 GO:0051769 BP 1 regulation of nitric-oxide synthase biosynthetic process 1 P09211 368 2.36e-02 8 4 1 0.250 0.125 GO:0051767 BP 1 nitric-oxide synthase biosynthetic process 1 P09211 368 2.65e-02 9 4 1 0.250 0.111 GO:0010804 BP 1 negative regulation of tumor necrosis factor-mediated signaling pathway 1 P09211 368 2.94e-02 10 4 1 0.250 0.100 GO:0008143 MF 1 poly(A) binding 1 P31483 368 2.94e-02 10 4 1 0.250 0.100 GO:0032682 BP 1 negative regulation of chemokine production 1 P09211 368 3.17e-02 1157 4 3 0.750 0.003 GO:0071310 BP 1 cellular response to organic substance 1 P09211,P31483,Q01085 368 3.24e-02 11 4 1 0.250 0.091 GO:0042554 BP 1 superoxide anion generation 1 P09211 368 3.47e-02 309 4 2 0.500 0.006 REAC:5654738 rea 1 Signaling by FGFR2 1 P31483,Q01085 368 3.52e-02 311 4 2 0.500 0.006 REAC:190236 rea 1 Signaling by FGFR 1 P31483,Q01085 368 3.53e-02 12 4 1 0.250 0.083 GO:0004602 MF 1 glutathione peroxidase activity 1 P09211 368 3.68e-02 316 4 2 0.500 0.006 GO:0071363 BP 1 cellular response to growth factor stimulus 1 P31483,Q01085 368 3.76e-02 2 4 1 0.250 0.500 TF:M06001_1 tf 1 Factor: ZNF316; motif: RTTGAAAAGM; match class: 1 1 P31483 368 3.91e-02 326 4 2 0.500 0.006 GO:0070848 BP 1 response to growth factor 1 P31483,Q01085 368 4.12e-02 14 4 1 0.250 0.071 GO:0090322 BP 1 regulation of superoxide metabolic process 1 P09211 368 4.41e-02 15 4 1 0.250 0.067 GO:0070717 MF 1 poly-purine tract binding 1 P31483 368 4.41e-02 15 4 1 0.250 0.067 GO:0043651 BP 1 linoleic acid metabolic process 1 P09211 368 4.41e-02 15 4 1 0.250 0.067 GO:0048147 BP 1 negative regulation of fibroblast proliferation 1 P09211 368 4.67e-02 28 4 1 0.250 0.036 HP:0003376 hp 1 Steppage gait 1 P31483 368 5.00e-02 27 4 1 0.250 0.037 REAC:3299685 rea 1 Detoxification of Reactive Oxygen Species 1 P09211 368 5.00e-02 45 4 1 0.250 0.022 KEGG:00480 keg 1 Glutathione metabolism 1 P09211 368 5.00e-02 30 4 1 0.250 0.033 HP:0008180 hp 1 Mildly elevated creatine phosphokinase 1 P31483 368 5.00e-02 152 4 2 0.500 0.013 TF:M02263_0 tf 1 Factor: NFE2L2; motif: RTGACWCAGCA; match class: 0 1 P09211,Q01085 368 5.00e-02 17 4 1 0.250 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 P09211 368 5.00e-02 394 4 3 0.750 0.008 MI:mmu-miR-706 mi 1 MI:mmu-miR-706 1 Q96CN7,P31483,Q01085 368 5.00e-02 3 4 1 0.250 0.333 OMIM:254130 omi 1 Miyoshi Muscular Dystrophy 1 P31483 369 1.29e-02 313 3 2 0.667 0.006 MI:hsa-miR-26a-2* mi 1 MI:hsa-miR-26a-2* 1 O14776,Q9ULC4 369 2.62e-02 447 3 2 0.667 0.004 MI:hsa-miR-517a mi 1 MI:hsa-miR-517a 1 O14776,Q9ULC4 369 2.63e-02 215 3 2 0.667 0.009 TF:M03948_1 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 1 Q5VWI1,Q9ULC4 369 2.82e-02 464 3 2 0.667 0.004 MI:hsa-miR-517c mi 1 MI:hsa-miR-517c 1 O14776,Q9ULC4 369 2.88e-02 469 3 2 0.667 0.004 MI:hsa-miR-377 mi 1 MI:hsa-miR-377 1 O14776,Q9ULC4 369 3.10e-02 487 3 2 0.667 0.004 MI:hsa-miR-520h mi 1 MI:hsa-miR-520h 1 O14776,Q9ULC4 369 3.51e-02 519 3 2 0.667 0.004 MI:hsa-miR-520e mi 1 MI:hsa-miR-520e 1 O14776,Q9ULC4 369 4.08e-02 268 3 2 0.667 0.007 TF:M04362_0 tf 1 Factor: HOXD12; motif: RGTCGTAAAAN; match class: 0 1 O14776,Q5VWI1 369 4.38e-02 7 3 1 0.333 0.143 GO:0032790 BP 1 ribosome disassembly 1 Q9ULC4 369 4.80e-02 608 3 2 0.667 0.003 MI:mmu-miR-466b-3-3p mi 1 MI:mmu-miR-466b-3-3p 1 O14776,Q9ULC4 369 4.92e-02 616 3 2 0.667 0.003 MI:mmu-miR-466d-3p mi 1 MI:mmu-miR-466d-3p 1 O14776,Q9ULC4 369 5.00e-02 297 3 2 0.667 0.007 TF:M00999_0 tf 1 Factor: AIRE; motif: WTNNNWNNTGGWWNNNWNGGNNWNWN; match class: 0 1 Q5VWI1,Q9ULC4 369 5.00e-02 8 3 1 0.333 0.125 GO:0001731 BP 1 formation of translation preinitiation complex 1 Q9ULC4 369 5.00e-02 621 3 2 0.667 0.003 MI:mmu-miR-466a-3p mi 1 MI:mmu-miR-466a-3p 1 O14776,Q9ULC4 370 2.74e-11 13 5 4 0.800 0.308 GO:0005868 CC 1 cytoplasmic dynein complex 1 O43237,Q9Y6G9,P63172,Q14204 370 4.06e-10 24 5 4 0.800 0.167 GO:0030286 CC 1 dynein complex 1 O43237,Q9Y6G9,P63172,Q14204 370 2.82e-07 117 5 4 0.800 0.034 GO:0005875 CC 1 microtubule associated complex 1 O43237,Q9Y6G9,P63172,Q14204 370 2.14e-04 23 5 2 0.400 0.087 GO:0045502 MF 1 dynein binding 1 Q9Y6G9,Q14204 370 2.54e-04 25 5 2 0.400 0.080 GO:0051293 BP 1 establishment of spindle localization 1 P63172,Q14204 370 2.75e-04 26 5 2 0.400 0.077 GO:0051653 BP 1 spindle localization 1 P63172,Q14204 370 4.34e-04 29 5 2 0.400 0.069 REAC:6811436 rea 1 COPI-independent Golgi-to-ER retrograde traffic 1 O43237,Q14204 370 5.24e-04 769 5 4 0.800 0.005 GO:0015630 CC 1 microtubule cytoskeleton 1 O43237,Q9Y6G9,P63172,Q14204 370 1.12e-03 933 5 4 0.800 0.004 GO:0044430 CC 1 cytoskeletal part 1 O43237,Q9Y6G9,P63172,Q14204 370 1.40e-03 38 5 3 0.600 0.079 KEGG:04962 keg 1 Vasopressin-regulated water reabsorption 1 O43237,Q9Y6G9,Q14204 370 1.68e-03 1033 5 4 0.800 0.004 GO:1902494 CC 1 catalytic complex 1 O43237,Q9Y6G9,P63172,Q14204 370 2.04e-03 1 5 1 0.200 1.000 OMIM:614228 omi 1 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2O; CMT2O;;CHARCOT-MARIE-TOOTH NEUROPATHY, AXONAL, TYPE 2O;;CHARCOT-MARIE-TOOTH DISEASE, AXONAL, AUTOSOMAL DOMINANT, TYPE 2O 1 Q14204 370 2.04e-03 1 5 1 0.200 1.000 OMIM:614563 omi 1 MENTAL RETARDATION, AUTOSOMAL DOMINANT 13; MRD13;;MENTAL RETARDATION, AUTOSOMAL DOMINANT, 13, WITH NEURONAL MIGRATIONDEFECTS 1 Q14204 370 2.37e-03 409 5 3 0.600 0.007 GO:0005813 CC 1 centrosome 1 O43237,Q9Y6G9,Q14204 370 2.71e-03 81 5 2 0.400 0.025 GO:0019886 BP 1 antigen processing and presentation of exogenous peptide antigen via MHC class II 1 O43237,Q14204 370 2.77e-03 73 5 2 0.400 0.027 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 O43237,Q14204 370 2.78e-03 82 5 2 0.400 0.024 GO:0002495 BP 1 antigen processing and presentation of peptide antigen via MHC class II 1 O43237,Q14204 370 2.85e-03 83 5 2 0.400 0.024 GO:0002504 BP 1 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1 O43237,Q14204 370 3.06e-03 1204 5 4 0.800 0.003 GO:0005856 CC 1 cytoskeleton 1 O43237,Q9Y6G9,P63172,Q14204 370 3.66e-03 474 5 3 0.600 0.006 GO:0005815 CC 1 microtubule organizing center 1 O43237,Q9Y6G9,Q14204 370 4.07e-03 2 5 1 0.200 0.500 OMIM:158600 omi 1 Lower Extremity-Predominant Spinal Muscular Atrophy 1 Q14204 370 4.68e-03 95 5 2 0.400 0.021 REAC:2132295 rea 1 MHC class II antigen presentation 1 O43237,Q14204 370 4.90e-03 2 5 1 0.200 0.500 GO:0045504 MF 1 dynein heavy chain binding 1 Q9Y6G9 370 5.93e-03 107 5 2 0.400 0.019 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 O43237,Q14204 370 7.31e-03 119 5 2 0.400 0.017 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 O43237,Q14204 370 7.34e-03 3 5 1 0.200 0.333 GO:0051959 MF 1 dynein light intermediate chain binding 1 Q14204 370 7.86e-03 67 5 3 0.600 0.045 KEGG:05132 keg 1 Salmonella infection 1 O43237,Q9Y6G9,Q14204 370 8.41e-03 143 5 2 0.400 0.014 GO:0002478 BP 1 antigen processing and presentation of exogenous peptide antigen 1 O43237,Q14204 370 8.53e-03 144 5 2 0.400 0.014 GO:0019884 BP 1 antigen processing and presentation of exogenous antigen 1 O43237,Q14204 370 9.25e-03 150 5 2 0.400 0.013 GO:0048002 BP 1 antigen processing and presentation of peptide antigen 1 O43237,Q14204 370 9.53e-03 657 5 3 0.600 0.005 GO:1903047 BP 1 mitotic cell cycle process 1 Q9Y6G9,P63172,Q14204 370 9.62e-03 153 5 2 0.400 0.013 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 O43237,Q14204 370 1.04e-02 142 5 2 0.400 0.014 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 O43237,Q14204 370 1.05e-02 376 5 2 0.400 0.005 MI:mmu-miR-687 mi 1 MI:mmu-miR-687 1 Q9Y6G9,P63172 370 1.13e-02 166 5 2 0.400 0.012 GO:0005874 CC 1 microtubule 1 P63172,Q14204 370 1.22e-02 5 5 1 0.200 0.200 GO:0030581 BP 1 symbiont intracellular protein transport in host 1 P63172 370 1.22e-02 5 5 1 0.200 0.200 GO:0051708 BP 1 intracellular protein transport in other organism involved in symbiotic interaction 1 P63172 370 1.22e-02 5 5 1 0.200 0.200 GO:0019060 BP 1 intracellular transport of viral protein in host cell 1 P63172 370 1.23e-02 173 5 2 0.400 0.012 GO:0019882 BP 1 antigen processing and presentation 1 O43237,Q14204 370 1.25e-02 721 5 3 0.600 0.004 GO:0000278 BP 1 mitotic cell cycle 1 Q9Y6G9,P63172,Q14204 370 1.45e-02 444 5 2 0.400 0.005 MI:hsa-miR-507 mi 1 MI:hsa-miR-507 1 Q9Y6G9,P63172 370 1.45e-02 445 5 2 0.400 0.004 MI:hsa-miR-871 mi 1 MI:hsa-miR-871 1 Q8IWZ8,P63172 370 1.49e-02 171 5 2 0.400 0.012 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 O43237,Q14204 370 1.57e-02 463 5 2 0.400 0.004 MI:hsa-miR-105 mi 1 MI:hsa-miR-105 1 Q9Y6G9,P63172 370 1.66e-02 477 5 2 0.400 0.004 MI:hsa-miR-106a mi 1 MI:hsa-miR-106a 1 O43237,P63172 370 1.71e-02 7 5 1 0.200 0.143 GO:0090267 BP 1 positive regulation of mitotic cell cycle spindle assembly checkpoint 1 Q9Y6G9 370 1.73e-02 487 5 2 0.400 0.004 MI:hsa-miR-323-3p mi 1 MI:hsa-miR-323-3p 1 Q8IWZ8,P63172 370 1.76e-02 491 5 2 0.400 0.004 MI:hsa-miR-543 mi 1 MI:hsa-miR-543 1 Q8IWZ8,P63172 370 1.77e-02 493 5 2 0.400 0.004 MI:hsa-let-7e* mi 1 MI:hsa-let-7e* 1 Q8IWZ8,P63172 370 1.87e-02 507 5 2 0.400 0.004 MI:mmu-miR-467a mi 1 MI:mmu-miR-467a 1 Q9Y6G9,P63172 370 1.94e-02 1457 5 4 0.800 0.003 REAC:168256 rea 1 Immune System 1 O43237,Q9Y6G9,P63172,Q14204 370 1.95e-02 518 5 2 0.400 0.004 MI:hsa-miR-365 mi 1 MI:hsa-miR-365 1 Q9Y6G9,P63172 370 1.96e-02 8 5 1 0.200 0.125 GO:0090232 BP 1 positive regulation of spindle checkpoint 1 Q9Y6G9 370 1.99e-02 524 5 2 0.400 0.004 MI:mmu-miR-467d mi 1 MI:mmu-miR-467d 1 Q8IWZ8,P63172 370 2.04e-02 531 5 2 0.400 0.004 MI:hsa-miR-34c-5p mi 1 MI:hsa-miR-34c-5p 1 Q9Y6G9,P63172 370 2.20e-02 9 5 1 0.200 0.111 GO:1901978 BP 1 positive regulation of cell cycle checkpoint 1 Q9Y6G9 370 2.20e-02 9 5 1 0.200 0.111 GO:0046719 BP 1 regulation by virus of viral protein levels in host cell 1 P63172 370 2.20e-02 9 5 1 0.200 0.111 GO:0034063 BP 1 stress granule assembly 1 Q14204 370 2.63e-02 2096 5 4 0.800 0.002 GO:0043234 CC 1 protein complex 1 O43237,Q9Y6G9,P63172,Q14204 370 2.69e-02 11 5 1 0.200 0.091 GO:1903504 BP 1 regulation of mitotic spindle checkpoint 1 Q9Y6G9 370 2.69e-02 11 5 1 0.200 0.091 GO:0090266 BP 1 regulation of mitotic cell cycle spindle assembly checkpoint 1 Q9Y6G9 370 2.79e-02 952 5 3 0.600 0.003 GO:0022402 BP 1 cell cycle process 1 Q9Y6G9,P63172,Q14204 370 2.86e-02 266 5 2 0.400 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 P63172,Q14204 370 2.93e-02 12 5 1 0.200 0.083 GO:0000132 BP 1 establishment of mitotic spindle orientation 1 P63172 370 3.03e-02 274 5 2 0.400 0.007 GO:0099081 CC 1 supramolecular polymer 1 P63172,Q14204 370 3.03e-02 274 5 2 0.400 0.007 GO:0099512 CC 1 supramolecular fiber 1 P63172,Q14204 370 3.08e-02 248 5 2 0.400 0.008 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 O43237,Q14204 370 3.12e-02 278 5 2 0.400 0.007 GO:0048193 BP 1 Golgi vesicle transport 1 O43237,Q14204 370 3.36e-02 289 5 2 0.400 0.007 GO:0051656 BP 1 establishment of organelle localization 1 P63172,Q14204 370 3.42e-02 14 5 1 0.200 0.071 GO:0090231 BP 1 regulation of spindle checkpoint 1 Q9Y6G9 370 3.48e-02 294 5 2 0.400 0.007 GO:0099080 CC 1 supramolecular complex 1 P63172,Q14204 370 3.88e-02 1 5 1 0.200 1.000 TF:M06667_1 tf 1 Factor: ZNF599; motif: KGGTTCAGGAGM; match class: 1 1 P63172 370 3.91e-02 16 5 1 0.200 0.062 GO:0033962 BP 1 cytoplasmic mRNA processing body assembly 1 Q14204 370 3.91e-02 16 5 1 0.200 0.062 GO:0040001 BP 1 establishment of mitotic spindle localization 1 P63172 370 4.35e-02 330 5 2 0.400 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 P63172,Q14204 370 4.38e-02 331 5 2 0.400 0.006 GO:0051640 BP 1 organelle localization 1 P63172,Q14204 370 4.39e-02 18 5 1 0.200 0.056 GO:0051294 BP 1 establishment of spindle orientation 1 P63172 370 4.42e-02 1118 5 3 0.600 0.003 GO:0044822 MF 1 poly(A) RNA binding 1 Q8IWZ8,Q9Y6G9,Q14204 370 4.53e-02 1128 5 3 0.600 0.003 GO:0007049 BP 1 cell cycle 1 Q9Y6G9,P63172,Q14204 370 5.00e-02 938 5 3 0.600 0.003 REAC:168249 rea 1 Innate Immune System 1 Q9Y6G9,P63172,Q14204 370 5.00e-02 1 5 1 0.200 1.000 HP:0011808 hp 1 Decreased patellar reflex 1 Q14204 370 5.00e-02 1168 5 3 0.600 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q9Y6G9,P63172,Q14204 370 5.00e-02 25 5 1 0.200 0.040 OMIM:118210 omi 1 Charcot-Marie-Tooth Disease Type 2 1 Q14204 370 5.00e-02 481 5 3 0.600 0.006 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 O43237,Q9Y6G9,Q14204 370 5.00e-02 124 5 3 0.600 0.024 KEGG:04145 keg 1 Phagosome 1 O43237,Q9Y6G9,Q14204 370 5.00e-02 1 5 1 0.200 1.000 HP:0010602 hp 1 Type 2 muscle fiber predominance 1 Q14204 371 1.64e-03 86 4 2 0.500 0.023 GO:0003774 MF 1 motor activity 1 P63167,Q7Z4S6 371 3.04e-03 117 4 2 0.500 0.017 GO:0005875 CC 1 microtubule associated complex 1 P63167,Q7Z4S6 371 3.49e-03 2 4 1 0.250 0.500 GO:2000393 BP 1 negative regulation of lamellipodium morphogenesis 1 Q14678 371 5.24e-03 3 4 1 0.250 0.333 GO:1902744 BP 1 negative regulation of lamellipodium organization 1 Q14678 371 6.99e-03 4 4 1 0.250 0.250 GO:1900028 BP 1 negative regulation of ruffle assembly 1 Q14678 371 8.73e-03 5 4 1 0.250 0.200 GO:0035413 BP 1 positive regulation of catenin import into nucleus 1 Q14678 371 1.06e-02 2187 4 4 1.000 0.002 TF:M00764_0 tf 1 Factor: HNF4; motif: TGAMCTTTGNCCN; match class: 0 1 P63167,Q14678,Q6P1L5,Q7Z4S6 371 1.33e-02 246 4 2 0.500 0.008 GO:1903829 BP 1 positive regulation of cellular protein localization 1 P63167,Q14678 371 1.40e-02 8 4 1 0.250 0.125 GO:0035024 BP 1 negative regulation of Rho protein signal transduction 1 Q14678 371 1.57e-02 9 4 1 0.250 0.111 GO:1900025 BP 1 negative regulation of substrate adhesion-dependent cell spreading 1 Q14678 371 1.57e-02 9 4 1 0.250 0.111 GO:2000392 BP 1 regulation of lamellipodium morphogenesis 1 Q14678 371 1.66e-02 340 4 2 0.500 0.006 MI:mmu-miR-694 mi 1 MI:mmu-miR-694 1 P63167,Q14678 371 1.88e-02 293 4 2 0.500 0.007 GO:1904951 BP 1 positive regulation of establishment of protein localization 1 P63167,Q14678 371 1.92e-02 11 4 1 0.250 0.091 GO:0072673 BP 1 lamellipodium morphogenesis 1 Q14678 371 1.97e-02 107 4 2 0.500 0.019 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 P63167,Q7Z4S6 371 2.09e-02 12 4 1 0.250 0.083 GO:1900027 BP 1 regulation of ruffle assembly 1 Q14678 371 2.21e-02 394 4 2 0.500 0.005 MI:hsa-miR-595 mi 1 MI:hsa-miR-595 1 P63167,Q14678 371 2.27e-02 13 4 1 0.250 0.077 GO:0005868 CC 1 cytoplasmic dynein complex 1 P63167 371 2.44e-02 14 4 1 0.250 0.071 GO:2000114 BP 1 regulation of establishment of cell polarity 1 Q14678 371 2.56e-02 3 4 1 0.250 0.333 REAC:111446 rea 1 Activation of BIM and translocation to mitochondria 1 P63167 371 2.58e-02 427 4 2 0.500 0.005 MI:hsa-miR-208b mi 1 MI:hsa-miR-208b 1 P63167,Q14678 371 2.62e-02 15 4 1 0.250 0.067 GO:0097178 BP 1 ruffle assembly 1 Q14678 371 2.79e-02 358 4 2 0.500 0.006 GO:0030036 BP 1 actin cytoskeleton organization 1 P63167,Q14678 371 2.79e-02 444 4 2 0.500 0.005 MI:hsa-miR-383 mi 1 MI:hsa-miR-383 1 Q14678,Q7Z4S6 371 2.79e-02 16 4 1 0.250 0.062 GO:0032878 BP 1 regulation of establishment or maintenance of cell polarity 1 Q14678 371 2.79e-02 16 4 1 0.250 0.062 GO:0035412 BP 1 regulation of catenin import into nucleus 1 Q14678 371 2.90e-02 453 4 2 0.500 0.004 MI:hsa-miR-300 mi 1 MI:hsa-miR-300 1 P63167,Q7Z4S6 371 2.94e-02 368 4 2 0.500 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 P63167,Q14678 371 2.96e-02 17 4 1 0.250 0.059 GO:0035411 BP 1 catenin import into nucleus 1 Q14678 371 3.05e-02 8 4 1 0.250 0.125 TF:M04467_0 tf 1 Factor: HNF4A; motif: RRGGTCAAAGTCCANN; match class: 0 1 Q7Z4S6 371 3.15e-02 473 4 2 0.500 0.004 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 P63167,Q14678 371 3.21e-02 477 4 2 0.500 0.004 MI:hsa-miR-498 mi 1 MI:hsa-miR-498 1 P63167,Q14678 371 3.49e-02 20 4 1 0.250 0.050 GO:1900077 BP 1 negative regulation of cellular response to insulin stimulus 1 Q14678 371 3.49e-02 20 4 1 0.250 0.050 GO:0046627 BP 1 negative regulation of insulin receptor signaling pathway 1 Q14678 371 3.62e-02 409 4 2 0.500 0.005 GO:0044463 CC 1 cell projection part 1 P63167,Q14678 371 3.79e-02 419 4 2 0.500 0.005 GO:0030029 BP 1 actin filament-based process 1 P63167,Q14678 371 3.83e-02 22 4 1 0.250 0.045 GO:0046580 BP 1 negative regulation of Ras protein signal transduction 1 Q14678 371 3.92e-02 529 4 2 0.500 0.004 MI:hsa-miR-548b-5p mi 1 MI:hsa-miR-548b-5p 1 P63167,Q14678 371 4.01e-02 23 4 1 0.250 0.043 GO:0051058 BP 1 negative regulation of small GTPase mediated signal transduction 1 Q14678 371 4.18e-02 24 4 1 0.250 0.042 GO:0031529 BP 1 ruffle organization 1 Q14678 371 4.18e-02 24 4 1 0.250 0.042 GO:0030286 CC 1 dynein complex 1 P63167 371 4.32e-02 556 4 2 0.500 0.004 MI:hsa-miR-15a mi 1 MI:hsa-miR-15a 1 Q14678,Q7Z4S6 371 4.35e-02 25 4 1 0.250 0.040 GO:0046626 BP 1 regulation of insulin receptor signaling pathway 1 Q14678 371 4.35e-02 25 4 1 0.250 0.040 GO:1900740 BP 1 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P63167 371 4.35e-02 25 4 1 0.250 0.040 GO:1900739 BP 1 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P63167 371 4.57e-02 12 4 1 0.250 0.083 TF:M03933_0 tf 1 Factor: ZNF143; motif: TWCCCAYAATGCAYYG; match class: 0 1 P63167 371 4.68e-02 467 4 2 0.500 0.004 GO:0070201 BP 1 regulation of establishment of protein localization 1 P63167,Q14678 371 4.70e-02 27 4 1 0.250 0.037 GO:0030837 BP 1 negative regulation of actin filament polymerization 1 Q14678 371 4.70e-02 27 4 1 0.250 0.037 GO:0051204 BP 1 protein insertion into mitochondrial membrane 1 P63167 371 4.70e-02 27 4 1 0.250 0.037 GO:1902743 BP 1 regulation of lamellipodium organization 1 Q14678 371 4.70e-02 27 4 1 0.250 0.037 GO:0001844 BP 1 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 P63167 371 4.87e-02 28 4 1 0.250 0.036 GO:0007292 BP 1 female gamete generation 1 P63167 371 4.87e-02 28 4 1 0.250 0.036 GO:0090303 BP 1 positive regulation of wound healing 1 Q14678 371 5.00e-02 38 4 1 0.250 0.026 KEGG:04962 keg 1 Vasopressin-regulated water reabsorption 1 P63167 371 5.00e-02 340 4 2 0.500 0.006 TF:M01856_1 tf 1 Factor: AML3; motif: AACCACAN; match class: 1 1 P63167,Q14678 371 5.00e-02 600 4 2 0.500 0.003 MI:mmu-miR-466d-5p mi 1 MI:mmu-miR-466d-5p 1 P63167,Q14678 371 5.00e-02 1 4 1 0.250 1.000 OMIM:135700 omi 1 FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 1; CFEOM1;;OPHTHALMOPLEGIA, CONGENITAL;;BLEPHAROPTOSIS WITH ABSENT EYE MOVEMENTS;;FEOM1 LOCUSFIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3B, INCLUDED; CFEOM3B,INCLUDED 1 Q7Z4S6 371 5.00e-02 483 4 2 0.500 0.004 GO:0051050 BP 1 positive regulation of transport 1 P63167,Q14678 371 5.00e-02 1 4 1 0.250 1.000 OMIM:612900 omi 1 CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 2; CPSQ2 1 Q14678 371 5.00e-02 2 4 1 0.250 0.500 HP:0012275 hp 1 Autosomal dominant inheritance with maternal imprinting 1 Q14678 371 5.00e-02 171 4 2 0.500 0.012 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 P63167,Q7Z4S6 371 5.00e-02 340 4 2 0.500 0.006 TF:M01759_1 tf 1 Factor: AML2; motif: AACCRCAA; match class: 1 1 P63167,Q14678 372 3.89e-09 56 8 5 0.625 0.089 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 O00443,Q13492,Q14677,O75146,O14976 372 1.42e-08 72 8 5 0.625 0.069 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 O00443,Q13492,Q14677,O75146,O14976 372 1.42e-08 72 8 5 0.625 0.069 REAC:421837 rea 1 Clathrin derived vesicle budding 1 O00443,Q13492,Q14677,O75146,O14976 372 1.76e-07 354 8 6 0.750 0.017 GO:0006897 BP 1 endocytosis 1 O00443,P53675,Q13492,Q8TEH3,O75146,O14976 372 2.25e-07 522 8 7 0.875 0.013 REAC:199991 rea 1 Membrane Trafficking 1 O00443,P53675,Q13492,Q14677,Q8TEH3,O75146,O14976 372 3.20e-07 549 8 7 0.875 0.013 REAC:5653656 rea 1 Vesicle-mediated transport 1 O00443,P53675,Q13492,Q14677,Q8TEH3,O75146,O14976 372 2.88e-06 99 8 4 0.500 0.040 GO:0030136 CC 1 clathrin-coated vesicle 1 P53675,Q13492,Q8TEH3,O75146 372 1.07e-05 34 8 3 0.375 0.088 GO:0030276 MF 1 clathrin binding 1 Q13492,Q14677,O75146 372 1.37e-05 146 8 4 0.500 0.027 GO:0006898 BP 1 receptor-mediated endocytosis 1 P53675,Q13492,O75146,O14976 372 1.39e-05 37 8 3 0.375 0.081 GO:0072583 BP 1 clathrin-dependent endocytosis 1 Q13492,O75146,O14976 372 1.98e-05 160 8 4 0.500 0.025 GO:0030135 CC 1 coated vesicle 1 P53675,Q13492,Q8TEH3,O75146 372 6.48e-05 958 8 6 0.750 0.006 GO:0016192 BP 1 vesicle-mediated transport 1 O00443,P53675,Q13492,Q8TEH3,O75146,O14976 372 7.31e-05 7 8 2 0.250 0.286 GO:0048268 BP 1 clathrin coat assembly 1 O00443,Q13492 372 8.98e-04 147 8 3 0.375 0.020 GO:0035091 MF 1 phosphatidylinositol binding 1 Q13492,Q8TEH3,O75146 372 1.04e-03 25 8 2 0.250 0.080 GO:0048008 BP 1 platelet-derived growth factor receptor signaling pathway 1 O00443,O75146 372 1.50e-03 30 8 2 0.250 0.067 GO:0005905 CC 1 clathrin-coated pit 1 P53675,Q13492 372 2.55e-03 2795 8 7 0.875 0.003 GO:0031982 CC 1 vesicle 1 O00443,P53675,Q13492,Q8TEH3,O95630,O75146,O14976 372 3.04e-03 222 8 3 0.375 0.014 GO:0016197 BP 1 endosomal transport 1 P53675,Q13492,Q8TEH3 372 3.13e-03 1 8 1 0.125 1.000 OMIM:614261 omi 1 MICROCEPHALY-CAPILLARY MALFORMATION SYNDROME; MICCAP 1 O95630 372 3.82e-03 240 8 3 0.375 0.013 GO:0005543 MF 1 phospholipid binding 1 Q13492,Q8TEH3,O75146 372 4.37e-03 51 8 2 0.250 0.039 GO:0048259 BP 1 regulation of receptor-mediated endocytosis 1 Q13492,O75146 372 4.54e-03 52 8 2 0.250 0.038 GO:0097060 CC 1 synaptic membrane 1 Q13492,O75146 372 4.90e-03 54 8 2 0.250 0.037 GO:0030665 CC 1 clathrin-coated vesicle membrane 1 Q13492,Q8TEH3 372 4.96e-03 531 8 3 0.375 0.006 MI:mmu-miR-467c mi 1 MI:mmu-miR-467c 1 O00443,O95630,O14976 372 5.18e-03 539 8 3 0.375 0.006 MI:hsa-let-7g* mi 1 MI:hsa-let-7g* 1 Q8TEH3,O95630,O14976 372 5.28e-03 4600 8 8 1.000 0.002 GO:0016020 CC 1 membrane 1 O00443,P53675,Q13492,Q14677,Q8TEH3,O95630,O75146,O14976 372 5.75e-03 1 8 1 0.125 1.000 GO:1905247 BP 1 positive regulation of aspartic-type peptidase activity 1 Q13492 372 5.75e-03 1 8 1 0.125 1.000 GO:1902961 BP 1 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 372 7.32e-03 2988 8 6 0.750 0.002 HPA:009020_03 hpa 1 colon; glandular cells[Uncertain,High] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 7.71e-03 3017 8 6 0.750 0.002 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 7.76e-03 68 8 2 0.250 0.029 GO:0046578 BP 1 regulation of Ras protein signal transduction 1 Q8TEH3,O95630 372 8.34e-03 3061 8 6 0.750 0.002 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 8.69e-03 625 8 3 0.375 0.005 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 9.19e-03 74 8 2 0.250 0.027 GO:0098794 CC 1 postsynapse 1 Q13492,O75146 372 1.10e-02 345 8 3 0.375 0.009 GO:0008289 MF 1 lipid binding 1 Q13492,Q8TEH3,O75146 372 1.11e-02 3228 8 6 0.750 0.002 HPA:037010_03 hpa 1 small intestine; glandular cells[Uncertain,High] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 1.15e-02 2 8 1 0.125 0.500 GO:1902962 BP 1 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 372 1.15e-02 2 8 1 0.125 0.500 GO:1902959 BP 1 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 372 1.15e-02 2 8 1 0.125 0.500 GO:1905245 BP 1 regulation of aspartic-type peptidase activity 1 Q13492 372 1.15e-02 2 8 1 0.125 0.500 GO:2000588 BP 1 positive regulation of platelet-derived growth factor receptor-beta signaling pathway 1 O75146 372 1.15e-02 2 8 1 0.125 0.500 GO:0072318 BP 1 clathrin coat disassembly 1 O14976 372 1.15e-02 2 8 1 0.125 0.500 GO:1902963 BP 1 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 1 Q13492 372 1.23e-02 3292 8 6 0.750 0.002 HPA:016010_03 hpa 1 gallbladder; glandular cells[Uncertain,High] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 1.23e-02 359 8 3 0.375 0.008 GO:0051129 BP 1 negative regulation of cellular component organization 1 Q13492,O75146,O14976 372 1.30e-02 2274 8 5 0.625 0.002 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q13492,Q14677,O95630,O75146,O14976 372 1.35e-02 258 8 2 0.250 0.008 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 O75146,O14976 372 1.41e-02 92 8 2 0.250 0.022 GO:0043025 CC 1 neuronal cell body 1 Q13492,O75146 372 1.45e-02 93 8 2 0.250 0.022 GO:1901981 MF 1 phosphatidylinositol phosphate binding 1 Q8TEH3,O75146 372 1.48e-02 94 8 2 0.250 0.021 GO:0010952 BP 1 positive regulation of peptidase activity 1 Q13492,O75146 372 1.57e-02 97 8 2 0.250 0.021 GO:0030662 CC 1 coated vesicle membrane 1 Q13492,Q8TEH3 372 1.57e-02 97 8 2 0.250 0.021 GO:0007173 BP 1 epidermal growth factor receptor signaling pathway 1 O00443,O75146 372 1.58e-02 391 8 3 0.375 0.008 GO:0043623 BP 1 cellular protein complex assembly 1 O00443,Q13492,O75146 372 1.70e-02 798 8 3 0.375 0.004 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 Q13492,Q14677,O75146 372 1.70e-02 798 8 3 0.375 0.004 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 Q13492,Q14677,O75146 372 1.72e-02 3 8 1 0.125 0.333 GO:0010641 BP 1 positive regulation of platelet-derived growth factor receptor signaling pathway 1 O75146 372 1.72e-02 3 8 1 0.125 0.333 GO:0072319 BP 1 vesicle uncoating 1 O14976 372 1.72e-02 910 8 4 0.500 0.004 GO:0097708 CC 1 intracellular vesicle 1 P53675,Q13492,Q8TEH3,O75146 372 1.80e-02 104 8 2 0.250 0.019 GO:0044297 CC 1 cell body 1 Q13492,O75146 372 1.88e-02 931 8 4 0.500 0.004 GO:0031410 CC 1 cytoplasmic vesicle 1 P53675,Q13492,Q8TEH3,O75146 372 1.94e-02 1 8 1 0.125 1.000 TF:M05623_1 tf 1 Factor: ZNF73; motif: NGNTGGWACAGA; match class: 1 1 O14976 372 1.94e-02 838 8 3 0.375 0.004 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 2.16e-02 114 8 2 0.250 0.018 GO:0038127 BP 1 ERBB signaling pathway 1 O00443,O75146 372 2.17e-02 2644 8 6 0.750 0.002 GO:0006810 BP 1 transport 1 O00443,P53675,Q13492,Q8TEH3,O75146,O14976 372 2.30e-02 4 8 1 0.125 0.250 GO:0032050 MF 1 clathrin heavy chain binding 1 Q13492 372 2.30e-02 4 8 1 0.125 0.250 GO:0097443 CC 1 sorting endosome 1 P53675 372 2.30e-02 4 8 1 0.125 0.250 GO:0097459 BP 1 iron ion import into cell 1 Q13492 372 2.30e-02 4 8 1 0.125 0.250 GO:0032483 BP 1 regulation of Rab protein signal transduction 1 Q8TEH3 372 2.30e-02 4 8 1 0.125 0.250 GO:1902004 BP 1 positive regulation of beta-amyloid formation 1 Q13492 372 2.30e-02 4 8 1 0.125 0.250 GO:1905049 BP 1 negative regulation of metallopeptidase activity 1 Q13492 372 2.30e-02 4 8 1 0.125 0.250 GO:1902993 BP 1 positive regulation of amyloid precursor protein catabolic process 1 Q13492 372 2.30e-02 4 8 1 0.125 0.250 GO:2000586 BP 1 regulation of platelet-derived growth factor receptor-beta signaling pathway 1 O75146 372 2.30e-02 4 8 1 0.125 0.250 GO:1904684 BP 1 negative regulation of metalloendopeptidase activity 1 Q13492 372 2.37e-02 902 8 3 0.375 0.003 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q13492,Q14677,O75146 372 2.39e-02 120 8 2 0.250 0.017 GO:0016482 BP 1 cytosolic transport 1 P53675,O14976 372 2.41e-02 3743 8 6 0.750 0.002 HPA:006020_02 hpa 1 cerebellum; cells in granular layer[Uncertain,Medium] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 2.51e-02 2 8 1 0.125 0.500 CORUM:1130 cor 1 Hip1R-cortactin complex 1 O75146 372 2.51e-02 2 8 1 0.125 0.500 CORUM:1784 cor 1 RNF11-SMURF2-STAMBP complex 1 O95630 372 2.51e-02 2647 8 5 0.625 0.002 HPA:001010_03 hpa 1 adrenal gland; glandular cells[Uncertain,High] 1 O00443,Q13492,Q14677,Q8TEH3,O95630 372 2.55e-02 124 8 2 0.250 0.016 GO:0030100 BP 1 regulation of endocytosis 1 Q13492,O75146 372 2.55e-02 361 8 2 0.250 0.006 MI:mmu-miR-712 mi 1 MI:mmu-miR-712 1 O95630,O75146 372 2.56e-02 362 8 2 0.250 0.006 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 O95630,O14976 372 2.59e-02 1015 8 4 0.500 0.004 GO:0071822 BP 1 protein complex subunit organization 1 O00443,Q13492,O75146,O14976 372 2.65e-02 9 8 1 0.125 0.111 HP:0010721 hp 1 Abnormal hair whorl 1 O95630 372 2.65e-02 9 8 1 0.125 0.111 HP:0001667 hp 1 Right ventricular hypertrophy 1 O95630 372 2.66e-02 942 8 3 0.375 0.003 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q13492,Q14677,O75146 372 2.68e-02 2748 8 6 0.750 0.002 GO:0051234 BP 1 establishment of localization 1 O00443,P53675,Q13492,Q8TEH3,O75146,O14976 372 2.87e-02 5 8 1 0.125 0.200 GO:0016188 BP 1 synaptic vesicle maturation 1 Q13492 372 2.87e-02 5 8 1 0.125 0.200 GO:0014067 BP 1 negative regulation of phosphatidylinositol 3-kinase signaling 1 O95630 372 2.87e-02 5 8 1 0.125 0.200 GO:0032482 BP 1 Rab protein signal transduction 1 Q8TEH3 372 2.87e-02 5 8 1 0.125 0.200 GO:1904683 BP 1 regulation of metalloendopeptidase activity 1 Q13492 372 2.87e-02 5 8 1 0.125 0.200 GO:0097418 CC 1 neurofibrillary tangle 1 Q13492 372 2.87e-02 5 8 1 0.125 0.200 GO:1905048 BP 1 regulation of metallopeptidase activity 1 Q13492 372 2.87e-02 5 8 1 0.125 0.200 GO:0014829 BP 1 vascular smooth muscle contraction 1 O00443 372 2.89e-02 973 8 3 0.375 0.003 HPA:023010_03 hpa 1 lymph node; germinal center cells[Uncertain,High] 1 O00443,Q13492,O75146 372 2.93e-02 977 8 3 0.375 0.003 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q13492,Q14677,O75146 372 2.98e-02 392 8 2 0.250 0.005 MI:mmu-miR-702 mi 1 MI:mmu-miR-702 1 Q8TEH3,O14976 372 3.01e-02 9 8 1 0.125 0.111 REAC:196025 rea 1 Formation of annular gap junctions 1 P53675 372 3.21e-02 2805 8 5 0.625 0.002 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 O00443,Q13492,Q14677,O95630,O75146 372 3.24e-02 2813 8 5 0.625 0.002 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 O00443,Q14677,O95630,O75146,O14976 372 3.29e-02 399 8 2 0.250 0.005 HPA:002020_13 hpa 1 appendix; lymphoid tissue[Supportive,High] 1 Q13492,O75146 372 3.31e-02 415 8 2 0.250 0.005 MI:hsa-miR-491-5p mi 1 MI:hsa-miR-491-5p 1 O95630,O14976 372 3.34e-02 10 8 1 0.125 0.100 REAC:1660517 rea 1 Synthesis of PIPs at the late endosome membrane 1 O00443 372 3.34e-02 10 8 1 0.125 0.100 REAC:190873 rea 1 Gap junction degradation 1 P53675 372 3.44e-02 6 8 1 0.125 0.167 GO:1902992 BP 1 negative regulation of amyloid precursor protein catabolic process 1 Q13492 372 3.44e-02 6 8 1 0.125 0.167 GO:0097286 BP 1 iron ion import 1 Q13492 372 3.44e-02 6 8 1 0.125 0.167 GO:0090160 BP 1 Golgi to lysosome transport 1 O14976 372 3.55e-02 2875 8 5 0.625 0.002 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 O00443,Q14677,O95630,O75146,O14976 372 3.70e-02 441 8 2 0.250 0.005 MI:hsa-miR-650 mi 1 MI:hsa-miR-650 1 O95630,O14976 372 3.70e-02 441 8 2 0.250 0.005 MI:hsa-miR-147b mi 1 MI:hsa-miR-147b 1 O95630,O14976 372 3.79e-02 1078 8 3 0.375 0.003 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 3.79e-02 1078 8 3 0.375 0.003 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 3.83e-02 449 8 2 0.250 0.004 MI:hsa-miR-591 mi 1 MI:hsa-miR-591 1 O95630,O14976 372 3.95e-02 155 8 2 0.250 0.013 GO:0098589 CC 1 membrane region 1 P53675,Q13492 372 4.02e-02 7 8 1 0.125 0.143 GO:0035005 MF 1 1-phosphatidylinositol-4-phosphate 3-kinase activity 1 O00443 372 4.02e-02 7 8 1 0.125 0.143 GO:0072600 BP 1 establishment of protein localization to Golgi 1 O14976 372 4.02e-02 7 8 1 0.125 0.143 GO:0032839 CC 1 dendrite cytoplasm 1 O75146 372 4.02e-02 7 8 1 0.125 0.143 GO:0035459 BP 1 cargo loading into vesicle 1 Q13492 372 4.14e-02 4163 8 6 0.750 0.001 HPA:023020_02 hpa 1 lymph node; non-germinal center cells[Uncertain,Medium] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 4.19e-02 472 8 2 0.250 0.004 MI:mmu-miR-290-5p mi 1 MI:mmu-miR-290-5p 1 Q8TEH3,O95630 372 4.19e-02 1121 8 3 0.375 0.003 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 4.27e-02 1129 8 3 0.375 0.003 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 4.27e-02 477 8 2 0.250 0.004 MI:hsa-miR-549 mi 1 MI:hsa-miR-549 1 O95630,O14976 372 4.31e-02 1133 8 3 0.375 0.003 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q13492,Q14677,O75146 372 4.33e-02 1135 8 3 0.375 0.003 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q13492,Q14677,O75146 372 4.35e-02 163 8 2 0.250 0.012 GO:0007265 BP 1 Ras protein signal transduction 1 Q8TEH3,O95630 372 4.41e-02 164 8 2 0.250 0.012 GO:0051056 BP 1 regulation of small GTPase mediated signal transduction 1 Q8TEH3,O95630 372 4.49e-02 490 8 2 0.250 0.004 MI:hsa-miR-371-5p mi 1 MI:hsa-miR-371-5p 1 Q8TEH3,O95630 372 4.51e-02 166 8 2 0.250 0.012 GO:0052548 BP 1 regulation of endopeptidase activity 1 Q13492,O75146 372 4.59e-02 8 8 1 0.125 0.125 GO:1902003 BP 1 regulation of beta-amyloid formation 1 Q13492 372 4.59e-02 8 8 1 0.125 0.125 GO:0032838 CC 1 cell projection cytoplasm 1 O75146 372 4.59e-02 8 8 1 0.125 0.125 GO:0034205 BP 1 beta-amyloid formation 1 Q13492 372 4.67e-02 14 8 1 0.125 0.071 REAC:190828 rea 1 Gap junction trafficking 1 P53675 372 4.67e-02 14 8 1 0.125 0.071 REAC:1660516 rea 1 Synthesis of PIPs at the early endosome membrane 1 O00443 372 4.73e-02 170 8 2 0.250 0.012 GO:0044456 CC 1 synapse part 1 Q13492,O75146 372 4.73e-02 486 8 2 0.250 0.004 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q13492,O75146 372 4.77e-02 229 8 2 0.250 0.009 KEGG:04144 keg 1 Endocytosis 1 P53675,O95630 372 4.88e-02 513 8 2 0.250 0.004 MI:mmu-miR-292-5p mi 1 MI:mmu-miR-292-5p 1 Q8TEH3,O95630 372 4.89e-02 173 8 2 0.250 0.012 GO:0036477 CC 1 somatodendritic compartment 1 Q13492,O75146 372 4.92e-02 4308 8 6 0.750 0.001 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 O00443,Q13492,Q14677,O95630,O75146,O14976 372 4.93e-02 497 8 2 0.250 0.004 HPA:007040_03 hpa 1 cerebral cortex; neuropil[Uncertain,High] 1 O00443,O14976 372 5.00e-02 4 8 1 0.125 0.250 CORUM:1185 cor 1 EGFR-containing signaling complex 1 O00443 372 5.00e-02 15 8 1 0.125 0.067 REAC:1660514 rea 1 Synthesis of PIPs at the Golgi membrane 1 O00443 372 5.00e-02 175 8 2 0.250 0.011 GO:0052547 BP 1 regulation of peptidase activity 1 Q13492,O75146 373 3.61e-04 6 2 2 1.000 0.333 GO:0016589 CC 1 NURF complex 1 Q12830,Q8IXM2 373 1.08e-03 10 2 2 1.000 0.200 GO:0031010 CC 1 ISWI-type complex 1 Q12830,Q8IXM2 373 7.73e-03 4 2 1 0.500 0.250 CORUM:919 cor 1 hNURF complex 1 Q12830 373 7.73e-03 4 2 1 0.500 0.250 CORUM:100 cor 1 hNURF complex 1 Q12830 373 1.07e-02 4 2 1 0.500 0.250 TF:M02272_1 tf 1 Factor: RXR:RAR; motif: RGKTCANNNRGAGGTCA; match class: 1 1 Q8IXM2 373 2.96e-02 161 2 1 0.500 0.006 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 Q8IXM2 373 3.22e-02 12 2 1 0.500 0.083 TF:M06534_1 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 1 1 Q12830 373 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q8IXM2 373 4.87e-02 276 2 1 0.500 0.004 MI:hsa-miR-96* mi 1 MI:hsa-miR-96* 1 Q12830 373 4.87e-02 680 2 2 1.000 0.003 TF:M04194_1 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 1 1 Q12830,Q8IXM2 373 4.94e-02 280 2 1 0.500 0.004 MI:hsa-miR-335* mi 1 MI:hsa-miR-335* 1 Q12830 373 5.00e-02 65 2 2 1.000 0.031 GO:0070603 CC 1 SWI/SNF superfamily-type complex 1 Q12830,Q8IXM2 373 5.00e-02 26 2 1 0.500 0.038 CORUM:5386 cor 1 MLL1-WDR5 complex 1 Q8IXM2 373 5.00e-02 689 2 2 1.000 0.003 TF:M00539_0 tf 1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 0 1 Q12830,Q8IXM2 373 5.00e-02 689 2 2 1.000 0.003 TF:M00539_1 tf 1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 1 Q12830,Q8IXM2 374 6.23e-05 54 6 3 0.500 0.056 GO:0035591 MF 1 signaling adaptor activity 1 Q9UQC2,O75791,Q13480 374 4.80e-04 106 6 3 0.500 0.028 GO:0030674 MF 1 protein binding, bridging 1 Q9UQC2,O75791,Q13480 374 6.97e-04 120 6 3 0.500 0.025 GO:0060090 MF 1 binding, bridging 1 Q9UQC2,O75791,Q13480 374 2.14e-03 553 6 3 0.500 0.005 MI:hsa-miR-29c mi 1 MI:hsa-miR-29c 1 O43572,Q13480,Q9H706 374 4.67e-03 32 6 2 0.333 0.062 REAC:5655302 rea 1 Signaling by FGFR1 in disease 1 Q9UQC2,Q13480 374 5.10e-03 38 6 2 0.333 0.053 GO:0005070 MF 1 SH3/SH2 adaptor activity 1 O75791,Q13480 374 1.02e-02 4357 6 6 1.000 0.001 TF:M02028_0 tf 1 Factor: Pbx1; motif: ATCAATCAN; match class: 0 1 Q9UQC2,Q9H3S7,O75791,O43572,Q13480,Q9H706 374 1.09e-02 314 6 2 0.333 0.006 MI:hsa-miR-24-1* mi 1 MI:hsa-miR-24-1* 1 Q9H3S7,Q9H706 374 1.15e-02 322 6 2 0.333 0.006 MI:hsa-miR-24-2* mi 1 MI:hsa-miR-24-2* 1 Q9H3S7,Q9H706 374 1.34e-02 54 6 2 0.333 0.037 REAC:1226099 rea 1 Signaling by FGFR in disease 1 Q9UQC2,Q13480 374 1.50e-02 4643 6 6 1.000 0.001 TF:M03846_0 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 0 1 Q9UQC2,Q9H3S7,O75791,O43572,Q13480,Q9H706 374 1.50e-02 5 6 1 0.167 0.200 TF:M06662_0 tf 1 Factor: znf426; motif: GAAACGASAATG; match class: 0 1 O75791 374 1.59e-02 271 6 3 0.500 0.011 REAC:1433557 rea 1 Signaling by SCF-KIT 1 Q9UQC2,O75791,Q13480 374 1.62e-02 386 6 2 0.333 0.005 MI:hsa-miR-378* mi 1 MI:hsa-miR-378* 1 Q9H3S7,Q13480 374 1.69e-02 1 6 1 0.167 1.000 GO:1903387 BP 1 positive regulation of homophilic cell adhesion 1 Q9H3S7 374 1.70e-02 173 6 2 0.333 0.012 TF:M07374_0 tf 1 Factor: Bach1; motif: GCTGAGTCAYGNT; match class: 0 1 Q9UQC2,Q13480 374 1.89e-02 703 6 3 0.500 0.004 TF:M04048_0 tf 1 Factor: MYBL2; motif: NNAACCGTTAN; match class: 0 1 Q9H3S7,O75791,Q13480 374 1.90e-02 419 6 2 0.333 0.005 MI:hsa-miR-192 mi 1 MI:hsa-miR-192 1 Q9H3S7,O43572 374 1.93e-02 423 6 2 0.333 0.005 MI:hsa-miR-628-3p mi 1 MI:hsa-miR-628-3p 1 O43572,Q9H706 374 1.94e-02 424 6 2 0.333 0.005 MI:mml-miR-189 mi 1 MI:mml-miR-189 1 Q9H3S7,O43572 374 1.94e-02 424 6 2 0.333 0.005 MI:mml-miR-000 mi 1 mml miRBase microRNAs 1 Q9H3S7,O43572 374 1.95e-02 425 6 2 0.333 0.005 MI:hsa-miR-649 mi 1 MI:hsa-miR-649 1 Q9H3S7,Q9H706 374 2.04e-02 435 6 2 0.333 0.005 MI:hsa-miR-10b mi 1 MI:hsa-miR-10b 1 O75791,O43572 374 2.05e-02 437 6 2 0.333 0.005 MI:hsa-miR-217 mi 1 MI:hsa-miR-217 1 O43572,Q13480 374 2.09e-02 441 6 2 0.333 0.005 MI:hsa-miR-10a mi 1 MI:hsa-miR-10a 1 O75791,O43572 374 2.10e-02 7 6 1 0.167 0.143 TF:M06326_0 tf 1 Factor: ZNF841; motif: NKGTCAAGAAAM; match class: 0 1 O75791 374 2.17e-02 450 6 2 0.333 0.004 MI:hsa-miR-215 mi 1 MI:hsa-miR-215 1 Q9H3S7,O43572 374 2.24e-02 305 6 3 0.500 0.010 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 Q9UQC2,O75791,Q13480 374 2.39e-02 474 6 2 0.333 0.004 MI:hsa-miR-369-3p mi 1 MI:hsa-miR-369-3p 1 O43572,Q13480 374 2.46e-02 1707 6 4 0.667 0.002 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q9H3S7,O43572,Q13480,Q9H706 374 2.54e-02 117 6 2 0.333 0.017 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 Q9UQC2,Q13480 374 2.58e-02 493 6 2 0.333 0.004 MI:hsa-miR-574-5p mi 1 MI:hsa-miR-574-5p 1 Q9H3S7,O43572 374 2.58e-02 784 6 3 0.500 0.004 TF:M00426_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 Q9H3S7,Q13480,Q9H706 374 2.65e-02 217 6 2 0.333 0.009 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 O43572,Q13480 374 2.93e-02 528 6 2 0.333 0.004 MI:hsa-miR-29a mi 1 MI:hsa-miR-29a 1 O43572,Q13480 374 3.03e-02 537 6 2 0.333 0.004 MI:hsa-miR-29b mi 1 MI:hsa-miR-29b 1 O43572,Q13480 374 3.30e-02 11 6 1 0.167 0.091 TF:M00079_1 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 1 1 Q9H706 374 3.30e-02 11 6 1 0.167 0.091 TF:M00080_1 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 1 1 Q9H706 374 3.33e-02 97 6 2 0.333 0.021 GO:0007173 BP 1 epidermal growth factor receptor signaling pathway 1 Q13480,Q9H706 374 3.43e-02 866 6 3 0.500 0.003 TF:M00024_0 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 0 1 Q9H3S7,O43572,Q13480 374 3.52e-02 251 6 2 0.333 0.008 TF:M01304_0 tf 1 Factor: SRF; motif: NNCCAWAWAAGGV; match class: 0 1 Q13480,Q9H706 374 3.69e-02 889 6 3 0.500 0.003 TF:M04044_0 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 0 1 Q9H3S7,O75791,Q13480 374 4.20e-02 14 6 1 0.167 0.071 TF:M02094_1 tf 1 Factor: ERR3; motif: NNTCAAGGTCACN; match class: 1 1 O43572 374 4.43e-02 112 6 2 0.333 0.018 GO:0038095 BP 1 Fc-epsilon receptor signaling pathway 1 Q9UQC2,O75791 374 4.50e-02 15 6 1 0.167 0.067 TF:M05973_0 tf 1 Factor: ZNF175; motif: NTGGTTAAAGGA; match class: 0 1 O75791 374 4.59e-02 114 6 2 0.333 0.018 GO:0038127 BP 1 ERBB signaling pathway 1 Q13480,Q9H706 374 4.80e-02 16 6 1 0.167 0.062 TF:M00062_0 tf 1 Factor: IRF-1; motif: SAAAAGYGAAACC; match class: 0 1 Q9H3S7 374 4.92e-02 118 6 2 0.333 0.017 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 Q9UQC2,Q13480 374 5.00e-02 2 6 1 0.167 0.500 CORUM:904 cor 1 SHC3-GAB1 complex 1 Q13480 374 5.00e-02 105 6 2 0.333 0.019 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 Q9UQC2,Q13480 374 5.00e-02 5674 6 6 1.000 0.001 TF:M00175_0 tf 1 Factor: AP-4; motif: VDCAGCTGNN; match class: 0 1 Q9UQC2,Q9H3S7,O75791,O43572,Q13480,Q9H706 374 5.00e-02 119 6 2 0.333 0.017 GO:0048017 BP 1 inositol lipid-mediated signaling 1 Q9UQC2,Q13480 374 5.00e-02 1 6 1 0.167 1.000 OMIM:115080 omi 1 CARDIAC CONDUCTION DEFECTSUDDEN CARDIAC DEATH, INCLUDED; SCD, INCLUDED;;FAMILIAL SUDDEN DEATH, INCLUDED 1 O43572 374 5.00e-02 166 6 2 0.333 0.012 KEGG:04014 keg 1 Ras signaling pathway 1 Q9UQC2,Q13480 375 1.36e-06 9 2 2 1.000 0.222 GO:0048531 MF 1 beta-1,3-galactosyltransferase activity 1 Q9NY97,Q96EU7 375 7.96e-06 21 2 2 1.000 0.095 GO:0008378 MF 1 galactosyltransferase activity 1 Q9NY97,Q96EU7 375 2.39e-05 36 2 2 1.000 0.056 GO:0016266 BP 1 O-glycan processing 1 Q9NY97,Q96EU7 375 5.71e-05 41 2 2 1.000 0.049 REAC:913709 rea 1 O-linked glycosylation of mucins 1 Q9NY97,Q96EU7 375 7.88e-05 65 2 2 1.000 0.031 GO:0006493 BP 1 protein O-linked glycosylation 1 Q9NY97,Q96EU7 375 1.78e-04 72 2 2 1.000 0.028 REAC:5173105 rea 1 O-linked glycosylation 1 Q9NY97,Q96EU7 375 3.58e-04 138 2 2 1.000 0.014 GO:0016758 MF 1 transferase activity, transferring hexosyl groups 1 Q9NY97,Q96EU7 375 5.38e-04 169 2 2 1.000 0.012 GO:0043413 BP 1 macromolecule glycosylation 1 Q9NY97,Q96EU7 375 5.38e-04 169 2 2 1.000 0.012 GO:0006486 BP 1 protein glycosylation 1 Q9NY97,Q96EU7 375 5.51e-04 171 2 2 1.000 0.012 GO:0070085 BP 1 glycosylation 1 Q9NY97,Q96EU7 375 7.02e-04 193 2 2 1.000 0.010 GO:0016757 MF 1 transferase activity, transferring glycosyl groups 1 Q9NY97,Q96EU7 375 8.74e-04 2 2 1 0.500 0.500 GO:0016267 BP 1 O-glycan processing, core 1 1 Q96EU7 375 8.74e-04 2 2 1 0.500 0.500 GO:0016263 MF 1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity 1 Q96EU7 375 9.38e-04 223 2 2 1.000 0.009 GO:0009101 BP 1 glycoprotein biosynthetic process 1 Q9NY97,Q96EU7 375 1.14e-03 246 2 2 1.000 0.008 GO:0009100 BP 1 glycoprotein metabolic process 1 Q9NY97,Q96EU7 375 1.75e-03 4 2 1 0.500 0.250 GO:0008532 MF 1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity 1 Q9NY97 375 1.75e-03 4 2 1 0.500 0.250 GO:0030309 BP 1 poly-N-acetyllactosamine metabolic process 1 Q9NY97 375 1.75e-03 4 2 1 0.500 0.250 GO:0030311 BP 1 poly-N-acetyllactosamine biosynthetic process 1 Q9NY97 375 2.08e-03 332 2 2 1.000 0.006 GO:0000139 CC 1 Golgi membrane 1 Q9NY97,Q96EU7 375 3.06e-03 7 2 1 0.500 0.143 GO:0008499 MF 1 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity 1 Q9NY97 375 3.69e-03 8 2 1 0.500 0.125 KEGG:00533 keg 1 Glycosaminoglycan biosynthesis - keratan sulfate 1 Q9NY97 375 4.10e-03 466 2 2 1.000 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q9NY97,Q96EU7 375 4.39e-03 482 2 2 1.000 0.004 GO:0044431 CC 1 Golgi apparatus part 1 Q9NY97,Q96EU7 375 6.62e-03 879 2 2 1.000 0.002 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 Q9NY97,Q96EU7 375 7.86e-03 18 2 1 0.500 0.056 GO:0035250 MF 1 UDP-galactosyltransferase activity 1 Q9NY97 375 8.30e-03 19 2 1 0.500 0.053 GO:0018146 BP 1 keratan sulfate biosynthetic process 1 Q9NY97 375 8.75e-03 19 2 1 0.500 0.053 KEGG:00512 keg 1 Mucin type O-glycan biosynthesis 1 Q96EU7 375 8.75e-03 19 2 1 0.500 0.053 KEGG:00601 keg 1 Glycosphingolipid biosynthesis - lacto and neolacto series 1 Q9NY97 375 9.55e-03 19 2 1 0.500 0.053 REAC:2022854 rea 1 Keratan sulfate biosynthesis 1 Q9NY97 375 1.05e-02 24 2 1 0.500 0.042 GO:0042339 BP 1 keratan sulfate metabolic process 1 Q9NY97 375 1.05e-02 1108 2 2 1.000 0.002 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 Q9NY97,Q96EU7 375 1.20e-02 798 2 2 1.000 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q9NY97,Q96EU7 375 1.21e-02 24 2 1 0.500 0.042 REAC:1638074 rea 1 Keratan sulfate/keratin metabolism 1 Q9NY97 375 1.35e-02 846 2 2 1.000 0.002 GO:0005794 CC 1 Golgi apparatus 1 Q9NY97,Q96EU7 375 1.40e-02 32 2 1 0.500 0.031 GO:0008375 MF 1 acetylglucosaminyltransferase activity 1 Q9NY97 375 1.69e-02 945 2 2 1.000 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 Q9NY97,Q96EU7 375 1.76e-02 712 2 2 1.000 0.003 REAC:597592 rea 1 Post-translational protein modification 1 Q9NY97,Q96EU7 375 1.83e-02 42 2 1 0.500 0.024 GO:0033692 BP 1 cellular polysaccharide biosynthetic process 1 Q9NY97 375 2.14e-02 49 2 1 0.500 0.020 GO:0034637 BP 1 cellular carbohydrate biosynthetic process 1 Q9NY97 375 2.14e-02 49 2 1 0.500 0.020 GO:0000271 BP 1 polysaccharide biosynthetic process 1 Q9NY97 375 2.44e-02 56 2 1 0.500 0.018 GO:0044264 BP 1 cellular polysaccharide metabolic process 1 Q9NY97 375 2.60e-02 364 2 2 1.000 0.005 MI:hsa-miR-497* mi 1 MI:hsa-miR-497* 1 Q9NY97,Q96EU7 375 2.88e-02 66 2 1 0.500 0.015 GO:0005976 BP 1 polysaccharide metabolic process 1 Q9NY97 375 2.96e-02 68 2 1 0.500 0.015 GO:1903510 BP 1 mucopolysaccharide metabolic process 1 Q9NY97 375 3.38e-02 415 2 2 1.000 0.005 MI:hsa-miR-455-5p mi 1 MI:hsa-miR-455-5p 1 Q9NY97,Q96EU7 375 3.61e-02 83 2 1 0.500 0.012 GO:0006023 BP 1 aminoglycan biosynthetic process 1 Q9NY97 375 3.61e-02 83 2 1 0.500 0.012 GO:0006024 BP 1 glycosaminoglycan biosynthetic process 1 Q9NY97 375 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q9NY97,Q96EU7 375 3.78e-02 1414 2 2 1.000 0.001 GO:0031090 CC 1 organelle membrane 1 Q9NY97,Q96EU7 375 4.13e-02 95 2 1 0.500 0.011 GO:0008194 MF 1 UDP-glycosyltransferase activity 1 Q9NY97 375 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q9NY97,Q96EU7 375 4.57e-02 105 2 1 0.500 0.010 GO:0030203 BP 1 glycosaminoglycan metabolic process 1 Q9NY97 375 4.76e-02 1169 2 2 1.000 0.002 REAC:392499 rea 1 Metabolism of proteins 1 Q9NY97,Q96EU7 375 4.83e-02 111 2 1 0.500 0.009 GO:0006022 BP 1 aminoglycan metabolic process 1 Q9NY97 375 5.00e-02 1 2 1 0.500 1.000 OMIM:300622 omi 1 TN POLYAGGLUTINATION SYNDROME; TNPS;;GALACTOSYLTRANSFERASE DEFICIENCY 1 Q96EU7 375 5.00e-02 100 2 1 0.500 0.010 REAC:1630316 rea 1 Glycosaminoglycan metabolism 1 Q9NY97 375 5.00e-02 505 2 2 1.000 0.004 MI:mmu-miR-878-3p mi 1 MI:mmu-miR-878-3p 1 Q9NY97,Q96EU7 375 5.00e-02 363 2 2 1.000 0.006 TF:M02162_0 tf 1 Factor: HNF1A; motif: GGTTAATNATTAMC; match class: 0 1 Q9NY97,Q96EU7 375 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 Q9NY97,Q96EU7 375 5.00e-02 115 2 1 0.500 0.009 GO:0016051 BP 1 carbohydrate biosynthetic process 1 Q9NY97 376 3.58e-03 1 3 1 0.333 1.000 GO:1904220 BP 1 regulation of serine C-palmitoyltransferase activity 1 Q9NRX5 376 3.58e-03 1 3 1 0.333 1.000 GO:1904222 BP 1 positive regulation of serine C-palmitoyltransferase activity 1 Q9NRX5 376 3.58e-03 1 3 1 0.333 1.000 GO:0004873 MF 1 asialoglycoprotein receptor activity 1 P07307 376 3.58e-03 1 3 1 0.333 1.000 GO:1904217 BP 1 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity 1 Q9NRX5 376 3.58e-03 1 3 1 0.333 1.000 GO:1904219 BP 1 positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity 1 Q9NRX5 376 1.07e-02 3 3 1 0.333 0.333 GO:0015825 BP 1 L-serine transport 1 Q9NRX5 376 1.07e-02 3 3 1 0.333 0.333 GO:0032329 BP 1 serine transport 1 Q9NRX5 376 1.16e-02 6 3 1 0.333 0.167 REAC:977347 rea 1 Serine biosynthesis 1 Q9NRX5 376 1.79e-02 5 3 1 0.333 0.200 GO:1905361 MF 1 L-serine transporter activity 1 Q9NRX5 376 1.79e-02 5 3 1 0.333 0.200 GO:0022889 MF 1 serine transmembrane transporter activity 1 Q9NRX5 376 1.79e-02 5 3 1 0.333 0.200 GO:0015194 MF 1 L-serine transmembrane transporter activity 1 Q9NRX5 376 4.64e-02 13 3 1 0.333 0.077 GO:0006658 BP 1 phosphatidylserine metabolic process 1 Q9NRX5 376 5.00e-02 26 3 1 0.333 0.038 REAC:70614 rea 1 Amino acid synthesis and interconversion (transamination) 1 Q9NRX5 376 5.00e-02 525 3 3 1.000 0.006 TF:M07357_0 tf 1 Factor: HNF-6; motif: RNNWAAATCAATAAN; match class: 0 1 Q9NRX5,Q9HAR2,P07307 376 5.00e-02 63 3 1 0.333 0.016 KEGG:04918 keg 1 Thyroid hormone synthesis 1 P07307 376 5.00e-02 14 3 1 0.333 0.071 GO:0015804 BP 1 neutral amino acid transport 1 Q9NRX5 377 6.50e-03 871 2 2 1.000 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P26599,Q8IX01 377 6.97e-03 902 2 2 1.000 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P26599,Q8IX01 377 7.04e-03 906 2 2 1.000 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P26599,Q8IX01 377 7.41e-03 930 2 2 1.000 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P26599,Q8IX01 377 7.54e-03 938 2 2 1.000 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P26599,Q8IX01 377 8.05e-03 969 2 2 1.000 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P26599,Q8IX01 377 8.18e-03 977 2 2 1.000 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P26599,Q8IX01 377 1.04e-02 1100 2 2 1.000 0.002 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P26599,Q8IX01 377 1.10e-02 1135 2 2 1.000 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P26599,Q8IX01 377 1.25e-02 4 2 1 0.500 0.250 CORUM:1288 cor 1 DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) 1 P26599 377 1.39e-02 1274 2 2 1.000 0.002 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P26599,Q8IX01 377 1.47e-02 1308 2 2 1.000 0.002 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P26599,Q8IX01 377 1.59e-02 1360 2 2 1.000 0.001 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P26599,Q8IX01 377 1.70e-02 1408 2 2 1.000 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P26599,Q8IX01 377 1.76e-02 290 2 2 1.000 0.007 MI:hsa-miR-23b* mi 1 MI:hsa-miR-23b* 1 P26599,Q8IX01 377 1.81e-02 1453 2 2 1.000 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P26599,Q8IX01 377 1.91e-02 1492 2 2 1.000 0.001 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P26599,Q8IX01 377 1.93e-02 303 2 2 1.000 0.007 MI:hsa-miR-593* mi 1 MI:hsa-miR-593* 1 P26599,Q8IX01 377 1.95e-02 7 2 1 0.500 0.143 GO:0075522 BP 1 IRES-dependent viral translational initiation 1 P26599 377 2.17e-02 1589 2 2 1.000 0.001 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P26599,Q8IX01 377 2.26e-02 1623 2 2 1.000 0.001 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P26599,Q8IX01 377 2.49e-02 1704 2 2 1.000 0.001 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P26599,Q8IX01 377 2.50e-02 2 2 1 0.500 0.500 TF:M05743_0 tf 1 Factor: ZNF57; motif: NGYTAGGGCAGA; match class: 0 1 Q8IX01 377 2.68e-02 1769 2 2 1.000 0.001 HPA:030010_12 hpa 1 prostate; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 2.74e-02 1788 2 2 1.000 0.001 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P26599,Q8IX01 377 2.77e-02 1797 2 2 1.000 0.001 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 2.78e-02 10 2 1 0.500 0.100 GO:0019081 BP 1 viral translation 1 P26599 377 2.82e-02 1813 2 2 1.000 0.001 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.03e-02 1880 2 2 1.000 0.001 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P26599,Q8IX01 377 3.04e-02 1883 2 2 1.000 0.001 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P26599,Q8IX01 377 3.06e-02 11 2 1 0.500 0.091 GO:0002192 BP 1 IRES-dependent translational initiation 1 P26599 377 3.11e-02 1904 2 2 1.000 0.001 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P26599,Q8IX01 377 3.13e-02 1909 2 2 1.000 0.001 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P26599,Q8IX01 377 3.20e-02 1932 2 2 1.000 0.001 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P26599,Q8IX01 377 3.21e-02 1933 2 2 1.000 0.001 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P26599,Q8IX01 377 3.26e-02 1950 2 2 1.000 0.001 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P26599,Q8IX01 377 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P26599,Q8IX01 377 3.39e-02 402 2 2 1.000 0.005 MI:hsa-miR-599 mi 1 MI:hsa-miR-599 1 P26599,Q8IX01 377 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.42e-02 1996 2 2 1.000 0.001 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P26599,Q8IX01 377 3.42e-02 1998 2 2 1.000 0.001 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 P26599,Q8IX01 377 3.52e-02 2026 2 2 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P26599,Q8IX01 377 3.57e-02 2039 2 2 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P26599,Q8IX01 377 3.61e-02 2051 2 2 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.61e-02 13 2 1 0.500 0.077 GO:0048025 BP 1 negative regulation of mRNA splicing, via spliceosome 1 P26599 377 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 P26599 377 3.73e-02 2086 2 2 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.75e-02 2092 2 2 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.76e-02 205 2 1 0.500 0.005 HPA:026020_13 hpa 1 ovary; ovarian stroma cells[Supportive,High] 1 P26599 377 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P26599,Q8IX01 377 3.82e-02 2110 2 2 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.83e-02 427 2 2 1.000 0.005 MI:hsa-miR-140-5p mi 1 MI:hsa-miR-140-5p 1 P26599,Q8IX01 377 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P26599,Q8IX01 377 3.89e-02 14 2 1 0.500 0.071 GO:0008187 MF 1 poly-pyrimidine tract binding 1 P26599 377 3.89e-02 14 2 1 0.500 0.071 GO:0002190 BP 1 cap-independent translational initiation 1 P26599 377 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P26599,Q8IX01 377 3.92e-02 2139 2 2 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P26599,Q8IX01 377 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P26599,Q8IX01 377 3.98e-02 2153 2 2 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.00e-02 2159 2 2 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.03e-02 2168 2 2 1.000 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P26599,Q8IX01 377 4.07e-02 2177 2 2 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P26599,Q8IX01 377 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P26599,Q8IX01 377 4.19e-02 2209 2 2 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P26599,Q8IX01 377 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.25e-02 2227 2 2 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P26599,Q8IX01 377 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P26599,Q8IX01 377 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P26599,Q8IX01 377 4.44e-02 2274 2 2 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P26599,Q8IX01 377 4.44e-02 2276 2 2 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.44e-02 16 2 1 0.500 0.062 GO:0002183 BP 1 cytoplasmic translational initiation 1 P26599 377 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.46e-02 2281 2 2 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.61e-02 2318 2 2 1.000 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P26599,Q8IX01 377 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.71e-02 2342 2 2 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P26599,Q8IX01 377 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 P26599,Q8IX01 377 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P26599,Q8IX01 377 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P26599,Q8IX01 377 5.00e-02 16 2 1 0.500 0.062 CORUM:1141 cor 1 CF IIAm complex (Cleavage factor IIAm complex) 1 P26599 377 5.00e-02 488 2 2 1.000 0.004 MI:hsa-miR-27a mi 1 MI:hsa-miR-27a 1 P26599,Q8IX01 377 5.00e-02 27 2 1 0.500 0.037 REAC:6803529 rea 1 FGFR2 alternative splicing 1 P26599 377 5.00e-02 18 2 1 0.500 0.056 GO:0036002 MF 1 pre-mRNA binding 1 P26599 377 5.00e-02 18 2 1 0.500 0.056 GO:0033119 BP 1 negative regulation of RNA splicing 1 P26599 378 3.14e-03 20 2 1 0.500 0.050 TF:M06331_0 tf 1 Factor: ZNF343; motif: KGGTCCGGCCGA; match class: 0 1 Q0VF96 378 8.62e-03 55 2 1 0.500 0.018 TF:M00279_0 tf 1 Factor: MIF-1; motif: NNGTTGCWWGGYAACNGS; match class: 0 1 P60002 378 1.10e-02 1338 2 2 1.000 0.001 TF:M06444_0 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 0 1 Q0VF96,P60002 378 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q0VF96 378 1.80e-02 1707 2 2 1.000 0.001 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q0VF96,P60002 378 1.92e-02 123 2 1 0.500 0.008 TF:M06483_0 tf 1 Factor: ZNF595; motif: NGTGGAGGAWGC; match class: 0 1 Q0VF96 378 2.50e-02 160 2 1 0.500 0.006 TF:M06451_0 tf 1 Factor: ZNF614; motif: NGGTCCWGMCGA; match class: 0 1 Q0VF96 378 2.58e-02 165 2 1 0.500 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 Q0VF96 378 2.61e-02 2057 2 2 1.000 0.001 TF:M00482_0 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 0 1 Q0VF96,P60002 378 3.03e-02 2216 2 2 1.000 0.001 TF:M00740_0 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 0 1 Q0VF96,P60002 378 3.09e-02 2238 2 2 1.000 0.001 TF:M00918_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 Q0VF96,P60002 378 3.23e-02 2288 2 2 1.000 0.001 TF:M00919_0 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 0 1 Q0VF96,P60002 378 3.31e-02 2317 2 2 1.000 0.001 TF:M00920_0 tf 1 Factor: E2F; motif: NKCGCGCSAAAN; match class: 0 1 Q0VF96,P60002 378 3.60e-02 231 2 1 0.500 0.004 TF:M04031_0 tf 1 Factor: MEIS3; motif: TGACAGSTGTCA; match class: 0 1 Q0VF96 378 3.61e-02 232 2 1 0.500 0.004 TF:M06798_0 tf 1 Factor: PRDM15; motif: NYGGGACTTT; match class: 0 1 Q0VF96 378 3.63e-02 233 2 1 0.500 0.004 TF:M05312_0 tf 1 Factor: FKLF; motif: AGGGCGGGTG; match class: 0 1 Q0VF96 378 3.63e-02 233 2 1 0.500 0.004 TF:M05360_0 tf 1 Factor: TIEG-1; motif: WGGGCGGGTG; match class: 0 1 Q0VF96 378 3.63e-02 233 2 1 0.500 0.004 TF:M05552_0 tf 1 Factor: SP5; motif: NGGGCGGGTS; match class: 0 1 Q0VF96 378 3.63e-02 233 2 1 0.500 0.004 TF:M05553_0 tf 1 Factor: SP8; motif: WGGGCGGGTS; match class: 0 1 Q0VF96 378 3.63e-02 233 2 1 0.500 0.004 TF:M05493_0 tf 1 Factor: SP9; motif: NGGGCGGGTS; match class: 0 1 Q0VF96 378 3.70e-02 238 2 1 0.500 0.004 TF:M03793_1 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 1 1 Q0VF96 378 3.73e-02 2459 2 2 1.000 0.001 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q0VF96,P60002 378 3.74e-02 2462 2 2 1.000 0.001 TF:M00939_0 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 0 1 Q0VF96,P60002 378 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 P60002 378 3.79e-02 2478 2 2 1.000 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q0VF96,P60002 378 3.92e-02 2521 2 2 1.000 0.001 TF:M05883_0 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 0 1 Q0VF96,P60002 378 4.35e-02 280 2 1 0.500 0.004 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 Q0VF96 378 4.64e-02 2743 2 2 1.000 0.001 TF:M04084_0 tf 1 Factor: POU3F4; motif: TGCATAAWTTA; match class: 0 1 Q0VF96,P60002 378 4.86e-02 313 2 1 0.500 0.003 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 Q0VF96 378 5.00e-02 7 2 1 0.500 0.143 GO:0048096 BP 1 chromatin-mediated maintenance of transcription 1 P60002 379 1.22e-22 20 11 9 0.818 0.450 REAC:392170 rea 1 ADP signalling through P2Y purinoceptor 12 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.94e-22 23 11 9 0.818 0.391 REAC:202040 rea 1 G-protein activation 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.40e-21 27 11 9 0.818 0.333 REAC:392518 rea 1 Signal amplification 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 9.01e-20 37 11 9 0.818 0.243 REAC:6814122 rea 1 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.23e-19 42 11 9 0.818 0.214 REAC:418597 rea 1 G alpha (z) signalling events 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.89e-18 25 11 8 0.727 0.320 REAC:400042 rea 1 Adrenaline,noradrenaline inhibits insulin secretion 1 P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.07e-17 67 11 9 0.818 0.134 REAC:418555 rea 1 G alpha (s) signalling events 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.61e-17 16 11 7 0.636 0.438 REAC:392851 rea 1 Prostacyclin signalling through prostacyclin receptor 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 6.13e-17 17 11 7 0.636 0.412 REAC:420092 rea 1 Glucagon-type ligand receptors 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 6.97e-17 73 11 9 0.818 0.123 REAC:111885 rea 1 Opioid Signalling 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.00e-16 18 11 7 0.636 0.389 REAC:418217 rea 1 G beta:gamma signalling through PLC beta 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.59e-16 19 11 7 0.636 0.368 REAC:500657 rea 1 Presynaptic function of Kainate receptors 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.59e-16 19 11 7 0.636 0.368 REAC:428930 rea 1 Thromboxane signalling through TP receptor 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.44e-16 20 11 7 0.636 0.350 REAC:418592 rea 1 ADP signalling through P2Y purinoceptor 1 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.29e-16 86 11 9 0.818 0.105 REAC:390466 rea 1 Chaperonin-mediated protein folding 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.60e-16 68 11 9 0.818 0.132 KEGG:04727 keg 1 GABAergic synapse 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.66e-16 31 11 7 0.636 0.226 GO:0071377 BP 1 cellular response to glucagon stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 6.21e-16 92 11 9 0.818 0.098 REAC:391251 rea 1 Protein folding 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 9.19e-16 33 11 7 0.636 0.212 GO:0033762 BP 1 response to glucagon 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 9.65e-16 72 11 9 0.818 0.125 KEGG:05032 keg 1 Morphine addiction 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.02e-15 97 11 9 0.818 0.093 REAC:418594 rea 1 G alpha (i) signalling events 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.51e-15 25 11 7 0.636 0.280 REAC:456926 rea 1 Thrombin signalling through proteinase activated receptors (PARs) 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.62e-15 80 11 9 0.818 0.113 KEGG:04723 keg 1 Retrograde endocannabinoid signaling 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.79e-15 27 11 7 0.636 0.259 REAC:451326 rea 1 Activation of Kainate Receptors upon glutamate binding 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.95e-15 81 11 9 0.818 0.111 KEGG:04713 keg 1 Circadian entrainment 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.71e-15 83 11 9 0.818 0.108 KEGG:04726 keg 1 Serotonergic synapse 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 4.61e-15 114 11 9 0.818 0.079 REAC:112314 rea 1 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 4.89e-15 29 11 7 0.636 0.241 REAC:991365 rea 1 Activation of GABAB receptors 1 P08754,P62873,P04899,P50150,P63218,O60262,P50151 379 4.89e-15 29 11 7 0.636 0.241 REAC:977444 rea 1 GABA B receptor activation 1 P08754,P62873,P04899,P50150,P63218,O60262,P50151 379 6.44e-15 88 11 9 0.818 0.102 KEGG:04725 keg 1 Cholinergic synapse 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 8.23e-15 31 11 7 0.636 0.226 REAC:163359 rea 1 Glucagon signaling in metabolic regulation 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 8.67e-15 65 11 8 0.727 0.123 REAC:422356 rea 1 Regulation of insulin secretion 1 P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.32e-14 95 11 9 0.818 0.095 KEGG:04724 keg 1 Glutamatergic synapse 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.68e-14 34 11 7 0.636 0.206 REAC:381676 rea 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.94e-14 99 11 9 0.818 0.091 KEGG:05034 keg 1 Alcoholism 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.10e-14 35 11 7 0.636 0.200 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.61e-14 36 11 7 0.636 0.194 REAC:432040 rea 1 Vasopressin regulates renal water homeostasis via Aquaporins 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.21e-14 37 11 7 0.636 0.189 REAC:977443 rea 1 GABA receptor activation 1 P08754,P62873,P04899,P50150,P63218,O60262,P50151 379 3.94e-14 38 11 7 0.636 0.184 REAC:397795 rea 1 G-protein beta:gamma signalling 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.94e-14 38 11 7 0.636 0.184 REAC:445717 rea 1 Aquaporin-mediated transport 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.65e-14 111 11 9 0.818 0.081 KEGG:04728 keg 1 Dopaminergic synapse 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.17e-13 120 11 9 0.818 0.075 KEGG:04062 keg 1 Chemokine signaling pathway 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.33e-13 164 11 9 0.818 0.055 REAC:112315 rea 1 Transmission across Chemical Synapses 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.41e-13 45 11 7 0.636 0.156 REAC:373080 rea 1 Class B/2 (Secretin family receptors) 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.89e-13 94 11 8 0.727 0.085 REAC:163685 rea 1 Integration of energy metabolism 1 P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.59e-13 51 11 7 0.636 0.137 REAC:4086398 rea 1 Ca2+ pathway 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.45e-12 213 11 9 0.818 0.042 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 4.52e-12 72 11 7 0.636 0.097 REAC:418346 rea 1 Platelet homeostasis 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.00e-12 73 11 7 0.636 0.096 REAC:416482 rea 1 G alpha (12/13) signalling events 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 6.71e-12 252 11 9 0.818 0.036 REAC:112316 rea 1 Neuronal System 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.64e-11 15 11 5 0.455 0.333 REAC:1296059 rea 1 G protein gated Potassium channels 1 P62873,P50150,P63218,O60262,P50151 379 1.64e-11 15 11 5 0.455 0.333 REAC:997272 rea 1 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 1 P62873,P50150,P63218,O60262,P50151 379 1.64e-11 15 11 5 0.455 0.333 REAC:1296041 rea 1 Activation of G protein gated Potassium channels 1 P62873,P50150,P63218,O60262,P50151 379 1.93e-11 88 11 7 0.636 0.080 REAC:416476 rea 1 G alpha (q) signalling events 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 8.45e-11 20 11 5 0.455 0.250 REAC:1296065 rea 1 Inwardly rectifying K+ channels 1 P62873,P50150,P63218,O60262,P50151 379 8.82e-11 158 11 7 0.636 0.044 GO:0003924 MF 1 GTPase activity 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 1.06e-10 342 11 9 0.818 0.026 REAC:388396 rea 1 GPCR downstream signaling 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.25e-10 166 11 7 0.636 0.042 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.61e-10 172 11 7 0.636 0.041 GO:1901653 BP 1 cellular response to peptide 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.31e-10 181 11 7 0.636 0.039 GO:0043434 BP 1 response to peptide hormone 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.98e-10 129 11 7 0.636 0.054 REAC:3858494 rea 1 Beta-catenin independent WNT signaling 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.25e-10 190 11 7 0.636 0.037 GO:1901652 BP 1 response to peptide 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.33e-10 140 11 7 0.636 0.050 REAC:500792 rea 1 GPCR ligand binding 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.03e-09 325 11 9 0.818 0.028 KEGG:05200 keg 1 Pathways in cancer 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.11e-09 444 11 9 0.818 0.020 REAC:109582 rea 1 Hemostasis 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.15e-09 15 11 4 0.364 0.267 GO:1905360 CC 1 GTPase complex 1 P08754,P62873,P04899,P63218 379 2.15e-09 15 11 4 0.364 0.267 GO:0005834 CC 1 heterotrimeric G-protein complex 1 P08754,P62873,P04899,P63218 379 2.95e-09 260 11 7 0.636 0.027 GO:0071417 BP 1 cellular response to organonitrogen compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 9.41e-09 307 11 7 0.636 0.023 GO:0010243 BP 1 response to organonitrogen compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.03e-08 311 11 7 0.636 0.023 GO:0032870 BP 1 cellular response to hormone stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.13e-08 315 11 7 0.636 0.022 GO:1901699 BP 1 cellular response to nitrogen compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.16e-08 577 11 9 0.818 0.016 REAC:372790 rea 1 Signaling by GPCR 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.34e-08 166 11 7 0.636 0.042 KEGG:04014 keg 1 Ras signaling pathway 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.44e-08 352 11 7 0.636 0.020 GO:0009725 BP 1 response to hormone 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.69e-08 357 11 7 0.636 0.020 GO:0007186 BP 1 G-protein coupled receptor signaling pathway 1 P08754,P62873,P04899,P50150,P63218,O60262,Q9NPQ8 379 2.88e-08 247 11 7 0.636 0.028 REAC:195721 rea 1 Signaling by Wnt 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.15e-08 61 11 5 0.455 0.082 REAC:1296071 rea 1 Potassium Channels 1 P62873,P50150,P63218,O60262,P50151 379 4.00e-08 378 11 7 0.636 0.019 GO:1901698 BP 1 response to nitrogen compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 8.16e-08 287 11 7 0.636 0.024 REAC:881907 rea 1 Gastrin-CREB signalling pathway via PKC and MAPK 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.22e-07 444 11 7 0.636 0.016 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.80e-07 257 11 7 0.636 0.027 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.53e-07 553 11 7 0.636 0.013 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 8.23e-07 586 11 7 0.636 0.012 GO:1901700 BP 1 response to oxygen-containing compound 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 8.62e-07 590 11 7 0.636 0.012 GO:0016462 MF 1 pyrophosphatase activity 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 8.82e-07 592 11 7 0.636 0.012 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 8.82e-07 592 11 7 0.636 0.012 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 1.55e-06 643 11 7 0.636 0.011 GO:0071495 BP 1 cellular response to endogenous stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.57e-06 72 11 4 0.364 0.056 GO:0031234 CC 1 extrinsic component of cytoplasmic side of plasma membrane 1 P08754,P62873,P04899,P63218 379 3.11e-06 712 11 7 0.636 0.010 GO:0009719 BP 1 response to endogenous stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.34e-06 493 11 7 0.636 0.014 REAC:382551 rea 1 Transmembrane transport of small molecules 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 5.13e-06 2420 11 10 0.909 0.004 GO:0005886 CC 1 plasma membrane 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 5.46e-06 98 11 4 0.364 0.041 GO:0019897 CC 1 extrinsic component of plasma membrane 1 P08754,P62873,P04899,P63218 379 5.82e-06 1169 11 9 0.818 0.008 REAC:392499 rea 1 Metabolism of proteins 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 6.24e-06 2469 11 10 0.909 0.004 GO:0071944 CC 1 cell periphery 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.14e-05 1882 11 9 0.818 0.005 GO:0042221 BP 1 response to chemical 1 P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.19e-05 119 11 4 0.364 0.034 GO:0009898 CC 1 cytoplasmic side of plasma membrane 1 P08754,P62873,P04899,P63218 379 1.45e-05 125 11 4 0.364 0.032 GO:0098797 CC 1 plasma membrane protein complex 1 P08754,P62873,P04899,P63218 379 1.52e-05 3755 11 11 1.000 0.003 GO:0051716 BP 1 cellular response to stimulus 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.74e-05 131 11 4 0.364 0.031 GO:0098562 CC 1 cytoplasmic side of membrane 1 P08754,P62873,P04899,P63218 379 3.15e-05 152 11 4 0.364 0.026 GO:0006457 BP 1 protein folding 1 P08754,P62873,P04899,Q9HAV0 379 4.21e-05 3004 11 10 0.909 0.003 GO:0007165 BP 1 signal transduction 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 5.62e-05 176 11 4 0.364 0.023 GO:0019898 CC 1 extrinsic component of membrane 1 P08754,P62873,P04899,P63218 379 7.59e-05 1575 11 9 0.818 0.006 REAC:162582 rea 1 Signal Transduction 1 P08754,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 7.81e-05 4356 11 11 1.000 0.003 GO:0050896 BP 1 response to stimulus 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 8.14e-05 1157 11 7 0.636 0.006 GO:0071310 BP 1 cellular response to organic substance 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 9.36e-05 3262 11 10 0.909 0.003 GO:0007154 BP 1 cell communication 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 9.53e-05 3268 11 10 0.909 0.003 GO:0044700 BP 1 single organism signaling 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 9.70e-05 3274 11 10 0.909 0.003 GO:0023052 BP 1 signaling 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.05e-04 9 11 2 0.182 0.222 GO:0031683 MF 1 G-protein beta/gamma-subunit complex binding 1 P08754,P04899 379 1.24e-04 215 11 4 0.364 0.019 GO:0098552 CC 1 side of membrane 1 P08754,P62873,P04899,P63218 379 1.31e-04 10 11 2 0.182 0.200 GO:0007194 BP 1 negative regulation of adenylate cyclase activity 1 P08754,P04899 379 1.31e-04 10 11 2 0.182 0.200 GO:0031280 BP 1 negative regulation of cyclase activity 1 P08754,P04899 379 1.37e-04 73 11 3 0.273 0.041 GO:0007188 BP 1 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 1 P08754,P62873,P04899 379 1.42e-04 4600 11 11 1.000 0.002 GO:0016020 CC 1 membrane 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.61e-04 77 11 3 0.273 0.039 GO:0007187 BP 1 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1 P08754,P62873,P04899 379 1.92e-04 12 11 2 0.182 0.167 GO:0051350 BP 1 negative regulation of lyase activity 1 P08754,P04899 379 2.01e-04 2627 11 9 0.818 0.003 GO:0044421 CC 1 extracellular region part 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,Q9NPQ8,P50151 379 2.64e-04 14 11 2 0.182 0.143 GO:0030803 BP 1 negative regulation of cyclic nucleotide biosynthetic process 1 P08754,P04899 379 2.64e-04 14 11 2 0.182 0.143 GO:0030818 BP 1 negative regulation of cAMP biosynthetic process 1 P08754,P04899 379 2.78e-04 1394 11 7 0.636 0.005 GO:0010033 BP 1 response to organic substance 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 2.90e-04 2743 11 9 0.818 0.003 GO:0005576 CC 1 extracellular region 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,Q9NPQ8,P50151 379 3.18e-04 1423 11 7 0.636 0.005 GO:0070887 BP 1 cellular response to chemical stimulus 1 P62873,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 3.48e-04 16 11 2 0.182 0.125 GO:0030800 BP 1 negative regulation of cyclic nucleotide metabolic process 1 P08754,P04899 379 3.48e-04 16 11 2 0.182 0.125 GO:0030815 BP 1 negative regulation of cAMP metabolic process 1 P08754,P04899 379 3.71e-04 14 11 2 0.182 0.143 REAC:997269 rea 1 Inhibition of adenylate cyclase pathway 1 P08754,P04899 379 3.71e-04 14 11 2 0.182 0.143 REAC:170670 rea 1 Adenylate cyclase inhibitory pathway 1 P08754,P04899 379 3.94e-04 17 11 2 0.182 0.118 GO:0030809 BP 1 negative regulation of nucleotide biosynthetic process 1 P08754,P04899 379 3.94e-04 17 11 2 0.182 0.118 GO:1900372 BP 1 negative regulation of purine nucleotide biosynthetic process 1 P08754,P04899 379 5.69e-04 2194 11 8 0.727 0.004 GO:0070062 CC 1 extracellular exosome 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,P50151 379 5.91e-04 2205 11 8 0.727 0.004 GO:0043230 CC 1 extracellular organelle 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,P50151 379 5.91e-04 2205 11 8 0.727 0.004 GO:1903561 CC 1 extracellular vesicle 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,P50151 379 7.01e-04 1607 11 7 0.636 0.004 GO:0016787 MF 1 hydrolase activity 1 P08754,P47736,P62873,P04899,P61952,P63218,P50151 379 7.97e-04 24 11 2 0.182 0.083 GO:0007212 BP 1 dopamine receptor signaling pathway 1 P08754,P62873 379 9.38e-04 26 11 2 0.182 0.077 GO:1900543 BP 1 negative regulation of purine nucleotide metabolic process 1 P08754,P04899 379 1.01e-03 27 11 2 0.182 0.074 GO:0045980 BP 1 negative regulation of nucleotide metabolic process 1 P08754,P04899 379 1.08e-03 6 11 2 0.182 0.333 CORUM:117 cor 1 GPR56-CD81-Galphaq/11-Gbeta complex 1 P62873,Q9HAV0 379 1.17e-03 384 11 4 0.364 0.010 GO:0032403 MF 1 protein complex binding 1 P08754,P62873,P04899,Q9HAV0 379 1.43e-03 32 11 2 0.182 0.062 GO:0045761 BP 1 regulation of adenylate cyclase activity 1 P08754,P04899 379 1.60e-03 1718 11 8 0.727 0.005 REAC:1430728 rea 1 Metabolism 1 P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 1.71e-03 35 11 2 0.182 0.057 GO:0007193 BP 1 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 1 P08754,P04899 379 1.84e-03 203 11 3 0.273 0.015 TF:M01233_1 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 1 1 Q9HAV0,P61952,P63218 379 2.02e-03 38 11 2 0.182 0.053 GO:0031279 BP 1 regulation of cyclase activity 1 P08754,P04899 379 2.04e-03 444 11 4 0.364 0.009 GO:0098796 CC 1 membrane protein complex 1 P08754,P62873,P04899,P63218 379 2.24e-03 40 11 2 0.182 0.050 GO:0051339 BP 1 regulation of lyase activity 1 P08754,P04899 379 2.33e-03 190 11 3 0.273 0.016 GO:0005765 CC 1 lysosomal membrane 1 P08754,P62873,Q9HAV0 379 2.33e-03 190 11 3 0.273 0.016 GO:0098852 CC 1 lytic vacuole membrane 1 P08754,P62873,Q9HAV0 379 2.58e-03 43 11 2 0.182 0.047 GO:0030817 BP 1 regulation of cAMP biosynthetic process 1 P08754,P04899 379 2.71e-03 44 11 2 0.182 0.045 GO:0006171 BP 1 cAMP biosynthetic process 1 P08754,P04899 379 3.09e-03 47 11 2 0.182 0.043 GO:0030802 BP 1 regulation of cyclic nucleotide biosynthetic process 1 P08754,P04899 379 3.22e-03 48 11 2 0.182 0.042 GO:0030814 BP 1 regulation of cAMP metabolic process 1 P08754,P04899 379 3.34e-03 2795 11 8 0.727 0.003 GO:0031982 CC 1 vesicle 1 P08754,P62873,P04899,Q9HAV0,P50150,P63218,O60262,P50151 379 3.37e-03 1 11 1 0.091 1.000 GO:1903697 BP 1 negative regulation of microvillus assembly 1 P47736 379 3.38e-03 216 11 3 0.273 0.014 GO:0005774 CC 1 vacuolar membrane 1 P08754,P62873,Q9HAV0 379 3.43e-03 42 11 2 0.182 0.048 REAC:112043 rea 1 PLC beta mediated events 1 P08754,P04899 379 3.59e-03 43 11 2 0.182 0.047 REAC:112040 rea 1 G-protein mediated events 1 P08754,P04899 379 3.63e-03 51 11 2 0.182 0.039 GO:1900371 BP 1 regulation of purine nucleotide biosynthetic process 1 P08754,P04899 379 3.64e-03 38 11 2 0.182 0.053 KEGG:04923 keg 1 Regulation of lipolysis in adipocytes 1 P08754,P04899 379 3.78e-03 52 11 2 0.182 0.038 GO:0030808 BP 1 regulation of nucleotide biosynthetic process 1 P08754,P04899 379 3.83e-03 39 11 2 0.182 0.051 KEGG:05030 keg 1 Cocaine addiction 1 P08754,P04899 379 4.07e-03 54 11 2 0.182 0.037 GO:0052652 BP 1 cyclic purine nucleotide metabolic process 1 P08754,P04899 379 4.22e-03 55 11 2 0.182 0.036 GO:0009190 BP 1 cyclic nucleotide biosynthetic process 1 P08754,P04899 379 4.38e-03 56 11 2 0.182 0.036 GO:0030799 BP 1 regulation of cyclic nucleotide metabolic process 1 P08754,P04899 379 4.38e-03 56 11 2 0.182 0.036 GO:0046058 BP 1 cAMP metabolic process 1 P08754,P04899 379 4.88e-03 155 11 3 0.273 0.019 KEGG:04015 keg 1 Rap1 signaling pathway 1 P08754,P47736,P04899 379 5.53e-03 47 11 2 0.182 0.043 KEGG:04924 keg 1 Renin secretion 1 P08754,P04899 379 6.25e-03 67 11 2 0.182 0.030 GO:0008277 BP 1 regulation of G-protein coupled receptor protein signaling pathway 1 P50150,O60262 379 6.49e-03 51 11 2 0.182 0.039 KEGG:04730 keg 1 Long-term depression 1 P08754,P04899 379 7.00e-03 53 11 2 0.182 0.038 KEGG:05133 keg 1 Pertussis 1 P08754,P04899 379 7.07e-03 279 11 3 0.273 0.011 GO:0044437 CC 1 vacuolar part 1 P08754,P62873,Q9HAV0 379 7.32e-03 429 11 3 0.273 0.007 MI:hsa-miR-218 mi 1 MI:hsa-miR-218 1 P04899,P61952,O60262 379 7.60e-03 74 11 2 0.182 0.027 GO:0031345 BP 1 negative regulation of cell projection organization 1 P47736,Q9NPQ8 379 7.81e-03 75 11 2 0.182 0.027 GO:0009187 BP 1 cyclic nucleotide metabolic process 1 P08754,P04899 379 8.35e-03 58 11 2 0.182 0.034 KEGG:04971 keg 1 Gastric acid secretion 1 P08754,P04899 379 8.62e-03 141 11 2 0.182 0.014 HPA:007040_13 hpa 1 cerebral cortex; neuropil[Supportive,High] 1 P62873,Q9HAV0 379 8.70e-03 348 11 3 0.273 0.009 TF:M01001_1 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 1 1 P62873,P50150,Q9NPQ8 379 9.35e-03 357 11 3 0.273 0.008 TF:M06246_0 tf 1 Factor: ZNF177; motif: NRWTGAAGAGCA; match class: 0 1 P50150,Q9NPQ8,P50151 379 9.90e-03 3668 11 8 0.727 0.002 TF:M00698_0 tf 1 Factor: HEB; motif: RCCWGCTG; match class: 0 1 P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262 379 1.01e-02 3 11 1 0.091 0.333 GO:0001973 BP 1 adenosine receptor signaling pathway 1 P04899 379 1.01e-02 3 11 1 0.091 0.333 GO:0035588 BP 1 G-protein coupled purinergic receptor signaling pathway 1 P04899 379 1.05e-02 87 11 2 0.182 0.023 GO:1900542 BP 1 regulation of purine nucleotide metabolic process 1 P08754,P04899 379 1.06e-02 690 11 4 0.364 0.006 GO:0044877 MF 1 macromolecular complex binding 1 P08754,P62873,P04899,Q9HAV0 379 1.15e-02 2831 11 7 0.636 0.002 TF:M01273_0 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 0 1 P47736,P62873,Q9HAV0,P50150,P63218,O60262,Q9NPQ8 379 1.17e-02 2048 11 6 0.545 0.003 TF:M02011_1 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 1 P47736,P62873,P04899,Q9HAV0,P50150,Q9NPQ8 379 1.19e-02 4 11 1 0.091 0.250 REAC:2485179 rea 1 Activation of the phototransduction cascade 1 P62873 379 1.21e-02 497 11 3 0.273 0.006 HPA:007040_03 hpa 1 cerebral cortex; neuropil[Uncertain,High] 1 P08754,P62873,Q9HAV0 379 1.24e-02 95 11 2 0.182 0.021 GO:0006140 BP 1 regulation of nucleotide metabolic process 1 P08754,P04899 379 1.26e-02 1 11 1 0.091 1.000 OMIM:615185 omi 1 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE F; CMTDIF 1 Q9HAV0 379 1.26e-02 1 11 1 0.091 1.000 OMIM:192605 omi 1 VENTRICULAR TACHYCARDIA, FAMILIAL;;VENTRICULAR TACHYCARDIA, FAMILIAL POLYMORPHIC 1 P04899 379 1.26e-02 1 11 1 0.091 1.000 OMIM:602483 omi 1 Auriculocondylar Syndrome 1 P08754 379 1.26e-02 342 11 3 0.273 0.009 GO:0005764 CC 1 lysosome 1 P08754,P62873,Q9HAV0 379 1.26e-02 342 11 3 0.273 0.009 GO:0000323 CC 1 lytic vacuole 1 P08754,P62873,Q9HAV0 379 1.32e-02 98 11 2 0.182 0.020 GO:0001664 MF 1 G-protein coupled receptor binding 1 P08754,P04899 379 1.32e-02 98 11 2 0.182 0.020 GO:0030496 CC 1 midbody 1 P08754,P04899 379 1.35e-02 4 11 1 0.091 0.250 GO:0097381 CC 1 photoreceptor disc membrane 1 P62873 379 1.37e-02 100 11 2 0.182 0.020 GO:0030308 BP 1 negative regulation of cell growth 1 P50150,Q9NPQ8 379 1.41e-02 5533 11 10 0.909 0.002 GO:0050794 BP 1 regulation of cellular process 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 1.41e-02 76 11 2 0.182 0.026 KEGG:04670 keg 1 Leukocyte transendothelial migration 1 P08754,P04899 379 1.43e-02 102 11 2 0.182 0.020 GO:0005525 MF 1 GTP binding 1 P08754,P04899 379 1.44e-02 3017 11 7 0.636 0.002 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 P08754,P47736,P62873,P04899,Q9HAV0,P63218,O60262 379 1.45e-02 77 11 2 0.182 0.026 KEGG:04916 keg 1 Melanogenesis 1 P08754,P04899 379 1.48e-02 78 11 2 0.182 0.026 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 P08754,P04899 379 1.56e-02 80 11 2 0.182 0.025 KEGG:04915 keg 1 Estrogen signaling pathway 1 P08754,P04899 379 1.59e-02 81 11 2 0.182 0.025 KEGG:04540 keg 1 Gap junction 1 P08754,P04899 379 1.59e-02 81 11 2 0.182 0.025 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 P08754,P04899 379 1.62e-02 3938 11 8 0.727 0.002 TF:M00072_0 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 0 1 P08754,P47736,P04899,Q9HAV0,P50150,P63218,Q9NPQ8,P50151 379 1.68e-02 5 11 1 0.091 0.200 GO:0001965 MF 1 G-protein alpha-subunit binding 1 Q9NPQ8 379 1.68e-02 5 11 1 0.091 0.200 GO:0035587 BP 1 purinergic receptor signaling pathway 1 P04899 379 1.68e-02 5 11 1 0.091 0.200 GO:0032534 BP 1 regulation of microvillus assembly 1 P47736 379 1.68e-02 5 11 1 0.091 0.200 GO:0071380 BP 1 cellular response to prostaglandin E stimulus 1 P62873 379 1.69e-02 111 11 2 0.182 0.018 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 P08754,P04899 379 1.71e-02 904 11 4 0.364 0.004 TF:M01273_1 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 1 P62873,P50150,O60262,Q9NPQ8 379 1.78e-02 114 11 2 0.182 0.018 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 P08754,P04899 379 1.81e-02 115 11 2 0.182 0.017 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 P08754,P04899 379 1.84e-02 116 11 2 0.182 0.017 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 P08754,P04899 379 1.88e-02 394 11 3 0.273 0.008 GO:0005773 CC 1 vacuole 1 P08754,P62873,Q9HAV0 379 1.90e-02 7 11 1 0.091 0.143 KEGG:04744 keg 1 Phototransduction 1 P62873 379 1.93e-02 6418 11 10 0.909 0.002 TF:M03920_0 tf 1 Factor: SP1; motif: RCCMCRCCCMC; match class: 0 1 P08754,P47736,P62873,P04899,Q9HAV0,P50150,P63218,O60262,Q9NPQ8,P50151 379 2.02e-02 6 11 1 0.091 0.167 GO:0034695 BP 1 response to prostaglandin E 1 P62873 379 2.03e-02 122 11 2 0.182 0.016 GO:0045926 BP 1 negative regulation of growth 1 P50150,Q9NPQ8 379 2.06e-02 123 11 2 0.182 0.016 GO:0032561 MF 1 guanyl ribonucleotide binding 1 P08754,P04899 379 2.09e-02 124 11 2 0.182 0.016 GO:0019001 MF 1 guanyl nucleotide binding 1 P08754,P04899 379 2.16e-02 95 11 2 0.182 0.021 KEGG:05145 keg 1 Toxoplasmosis 1 P08754,P04899 379 2.22e-02 128 11 2 0.182 0.016 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 P08754,P04899 379 2.31e-02 5839 11 10 0.909 0.002 GO:0050789 BP 1 regulation of biological process 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 2.35e-02 7 11 1 0.091 0.143 GO:0007214 BP 1 gamma-aminobutyric acid signaling pathway 1 P04899 379 2.43e-02 134 11 2 0.182 0.015 GO:0009165 BP 1 nucleotide biosynthetic process 1 P08754,P04899 379 2.50e-02 1 11 1 0.091 1.000 HP:0004751 hp 1 Paroxysmal ventricular tachycardia 1 P04899 379 2.52e-02 103 11 2 0.182 0.019 KEGG:04611 keg 1 Platelet activation 1 P08754,P04899 379 2.56e-02 104 11 2 0.182 0.019 KEGG:04071 keg 1 Sphingolipid signaling pathway 1 P08754,P04899 379 2.64e-02 10 11 1 0.091 0.100 TF:M06414_0 tf 1 Factor: ZNF573; motif: NGGTAAGGCANT; match class: 0 1 P50151 379 2.67e-02 3262 11 7 0.636 0.002 TF:M07251_1 tf 1 Factor: EHF; motif: BTTCCTGC; match class: 1 1 P08754,P47736,P62873,P61952,P50150,Q9NPQ8,P50151 379 2.69e-02 8 11 1 0.091 0.125 GO:0032530 BP 1 regulation of microvillus organization 1 P47736 379 2.69e-02 8 11 1 0.091 0.125 GO:0071379 BP 1 cellular response to prostaglandin stimulus 1 P62873 379 2.69e-02 8 11 1 0.091 0.125 GO:0007191 BP 1 adenylate cyclase-activating dopamine receptor signaling pathway 1 P62873 379 2.88e-02 5402 11 9 0.818 0.002 TF:M01104_1 tf 1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 1 P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 2.90e-02 111 11 2 0.182 0.018 KEGG:04530 keg 1 Tight junction 1 P08754,P04899 379 2.95e-02 112 11 2 0.182 0.018 KEGG:04740 keg 1 Olfactory transduction 1 P62873,O60262 379 2.95e-02 148 11 2 0.182 0.014 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 P08754,P04899 379 3.00e-02 3327 11 7 0.636 0.002 TF:M00982_1 tf 1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 1 P47736,P62873,P04899,P50150,P63218,O60262,Q9NPQ8 379 3.02e-02 9 11 1 0.091 0.111 GO:0007213 BP 1 G-protein coupled acetylcholine receptor signaling pathway 1 P62873 379 3.02e-02 9 11 1 0.091 0.111 GO:0034694 BP 1 response to prostaglandin 1 P62873 379 3.02e-02 9 11 1 0.091 0.111 GO:1905144 BP 1 response to acetylcholine 1 P62873 379 3.02e-02 9 11 1 0.091 0.111 GO:1905145 BP 1 cellular response to acetylcholine 1 P62873 379 3.02e-02 9 11 1 0.091 0.111 GO:1903831 BP 1 signal transduction involved in cellular response to ammonium ion 1 P62873 379 3.02e-02 9 11 1 0.091 0.111 GO:0095500 BP 1 acetylcholine receptor signaling pathway 1 P62873 379 3.08e-02 8381 11 11 1.000 0.001 TF:M01721_1 tf 1 Factor: PUR1; motif: GGGNCAGNN; match class: 1 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 3.25e-02 118 11 2 0.182 0.017 KEGG:05012 keg 1 Parkinson's disease 1 P08754,P04899 379 3.33e-02 4378 11 8 0.727 0.002 TF:M07285_0 tf 1 Factor: ESE-1; motif: NNYTTCCTG; match class: 0 1 P08754,P47736,P62873,Q9HAV0,P61952,P50150,P63218,Q9NPQ8 379 3.34e-02 2 11 1 0.091 0.500 CORUM:1614 cor 1 G protein complex (MCF2, GNB1, GNG2) 1 P62873 379 3.35e-02 2515 11 6 0.545 0.002 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 Q9HAV0,P50150,P63218,O60262,Q9NPQ8,P50151 379 3.42e-02 13 11 1 0.091 0.077 TF:M05533_0 tf 1 Factor: SZF1; motif: YGKAGCACAGCC; match class: 0 1 Q9NPQ8 379 3.46e-02 122 11 2 0.182 0.016 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 P08754,P04899 379 3.46e-02 305 11 2 0.182 0.007 MI:mmu-miR-718 mi 1 MI:mmu-miR-718 1 P04899,O60262 379 3.65e-02 1784 11 5 0.455 0.003 TF:M07409_1 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 1 P47736,P62873,P50150,O60262,Q9NPQ8 379 3.68e-02 166 11 2 0.182 0.012 GO:0051301 BP 1 cell division 1 P08754,P04899 379 3.69e-02 14 11 1 0.091 0.071 TF:M05642_0 tf 1 Factor: ZNF879; motif: NCGTCGGATANM; match class: 0 1 P08754 379 3.72e-02 167 11 2 0.182 0.012 GO:0005096 MF 1 GTPase activator activity 1 P47736,Q9NPQ8 379 3.83e-02 13 11 1 0.091 0.077 REAC:392517 rea 1 Rap1 signalling 1 P47736 379 3.89e-02 130 11 2 0.182 0.015 KEGG:04921 keg 1 Oxytocin signaling pathway 1 P08754,P04899 379 3.95e-02 15 11 1 0.091 0.067 TF:M05737_0 tf 1 Factor: ZNF699; motif: KGTGGCACGTGM; match class: 0 1 P04899 379 4.01e-02 3498 11 7 0.636 0.002 TF:M07433_0 tf 1 Factor: TCF-1; motif: NNNSWWCAAAGN; match class: 0 1 P08754,P47736,Q9HAV0,P61952,P63218,O60262,P50151 379 4.03e-02 12 11 1 0.091 0.083 GO:0038191 MF 1 neuropilin binding 1 Q9NPQ8 379 4.03e-02 12 11 1 0.091 0.083 GO:0046039 BP 1 GTP metabolic process 1 P08754 379 4.03e-02 6958 11 10 0.909 0.001 TF:M00076_0 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 0 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,P50151 379 4.17e-02 135 11 2 0.182 0.015 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 P08754,P04899 379 4.24e-02 6242 11 10 0.909 0.002 GO:0065007 BP 1 biological regulation 1 P08754,P47736,P62873,P04899,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 4.32e-02 1857 11 5 0.455 0.003 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 P47736,P62873,P50150,P63218,O60262 379 4.36e-02 13 11 1 0.091 0.077 GO:0016056 BP 1 rhodopsin mediated signaling pathway 1 P62873 379 4.47e-02 1033 11 4 0.364 0.004 GO:1902494 CC 1 catalytic complex 1 P08754,P62873,P04899,P63218 379 4.47e-02 7755 11 11 1.000 0.001 GO:0044699 BP 1 single-organism process 1 P08754,P47736,P62873,P04899,Q9HAV0,P61952,P50150,P63218,O60262,Q9NPQ8,P50151 379 4.69e-02 14 11 1 0.091 0.071 GO:0071398 BP 1 cellular response to fatty acid 1 P62873 379 4.78e-02 4622 11 8 0.727 0.002 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 P08754,P47736,P04899,Q9HAV0,P61952,O60262,Q9NPQ8,P50151 379 4.82e-02 146 11 2 0.182 0.014 KEGG:04024 keg 1 cAMP signaling pathway 1 P08754,P04899 379 4.99e-02 653 11 3 0.273 0.005 TF:M04332_1 tf 1 Factor: HMBOX1; motif: MYTAGTTAMN; match class: 1 1 Q9HAV0,P61952,P63218 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1620 cor 1 G protein complex (HDAC4, GNB1, GNG2) 1 P62873 379 5.00e-02 2 11 1 0.091 0.500 HP:0009088 hp 1 Speech articulation difficulties 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0009902 hp 1 Cleft helix 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0003778 hp 1 Short mandibular rami 1 P08754 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1615 cor 1 G protein complex (BTK, GNG1, GNG2) 1 P62873 379 5.00e-02 2 11 1 0.091 0.500 HP:3000003 hp 1 Abnormality of mandibular ramus 1 P08754 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1617 cor 1 G protein complex (CACNA1A, GNB1, GNG2) 1 P62873 379 5.00e-02 3635 11 7 0.636 0.002 TF:M00927_0 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 0 1 P47736,P62873,P04899,Q9HAV0,P50150,P63218,Q9NPQ8 379 5.00e-02 17 11 1 0.091 0.059 REAC:2514856 rea 1 The phototransduction cascade 1 P62873 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1618 cor 1 G protein complex (PTHR1, GNB1, GNG2) 1 P62873 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1619 cor 1 G protein complex (HDAC5, GNB1, GNG2) 1 P62873 379 5.00e-02 2 11 1 0.091 0.500 HP:0030022 hp 1 Question mark ear 1 P08754 379 5.00e-02 3 11 1 0.091 0.333 CORUM:1612 cor 1 Heterotrimeric G protein complex (GNG2, GNB1, GNAS) 1 P62873 379 5.00e-02 2 11 1 0.091 0.500 HP:0008513 hp 1 Bilateral conductive hearing impairment 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0007628 hp 1 Mandibular condyle hypoplasia 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0007627 hp 1 Mandibular condyle aplasia 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:3000077 hp 1 Abnormality of mandible condylar process 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0005790 hp 1 Short mandibular condyles 1 P08754 379 5.00e-02 17 11 1 0.091 0.059 REAC:2514859 rea 1 Inactivation, recovery and regulation of the phototransduction cascade 1 P62873 379 5.00e-02 195 11 2 0.182 0.010 GO:0030695 MF 1 GTPase regulator activity 1 P47736,Q9NPQ8 379 5.00e-02 4 11 1 0.091 0.250 OMIM:606482 omi 1 Autosomal Dominant Intermediate CMT 1 Q9HAV0 379 5.00e-02 2 11 1 0.091 0.500 HP:0004451 hp 1 Postauricular skin tag 1 P08754 379 5.00e-02 2 11 1 0.091 0.500 HP:0008537 hp 1 Cleft at the superior portion of the pinna 1 P08754 380 2.16e-02 233 1 1 1.000 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q01995 380 2.35e-02 219 1 1 1.000 0.005 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 Q01995 380 2.86e-02 124 1 1 1.000 0.008 GO:0007517 BP 1 muscle organ development 1 Q01995 380 2.92e-02 272 1 1 1.000 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 Q01995 380 3.25e-02 351 1 1 1.000 0.003 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 Q01995 380 3.69e-02 343 1 1 1.000 0.003 MI:hsa-miR-485-5p mi 1 MI:hsa-miR-485-5p 1 Q01995 380 3.77e-02 351 1 1 1.000 0.003 MI:hsa-miR-17* mi 1 MI:hsa-miR-17* 1 Q01995 380 3.77e-02 351 1 1 1.000 0.003 MI:gga-miR-456 mi 1 MI:gga-miR-456 1 Q01995 380 3.94e-02 366 1 1 1.000 0.003 MI:hsa-miR-672 mi 1 MI:hsa-miR-672 1 Q01995 380 3.96e-02 368 1 1 1.000 0.003 MI:hsa-miR-101* mi 1 MI:hsa-miR-101* 1 Q01995 380 4.00e-02 372 1 1 1.000 0.003 MI:hsa-miR-22* mi 1 MI:hsa-miR-22* 1 Q01995 380 4.03e-02 375 1 1 1.000 0.003 MI:hsa-miR-361-3p mi 1 MI:hsa-miR-361-3p 1 Q01995 380 4.08e-02 379 1 1 1.000 0.003 MI:mmu-miR-343 mi 1 MI:mmu-miR-343 1 Q01995 380 4.09e-02 380 1 1 1.000 0.003 MI:hsa-miR-188-3p mi 1 MI:hsa-miR-188-3p 1 Q01995 380 4.11e-02 382 1 1 1.000 0.003 MI:hsa-miR-637 mi 1 MI:hsa-miR-637 1 Q01995 380 4.15e-02 386 1 1 1.000 0.003 MI:hsa-miR-765 mi 1 MI:hsa-miR-765 1 Q01995 380 4.18e-02 389 1 1 1.000 0.003 MI:hsa-miR-920 mi 1 MI:hsa-miR-920 1 Q01995 380 4.24e-02 394 1 1 1.000 0.003 MI:hsa-miR-129-5p mi 1 MI:hsa-miR-129-5p 1 Q01995 380 4.39e-02 408 1 1 1.000 0.002 MI:mmu-miR-677 mi 1 MI:mmu-miR-677 1 Q01995 380 4.47e-02 416 1 1 1.000 0.002 MI:hsa-miR-98 mi 1 MI:hsa-miR-98 1 Q01995 380 4.48e-02 417 1 1 1.000 0.002 MI:hsa-miR-328 mi 1 MI:hsa-miR-328 1 Q01995 380 4.49e-02 418 1 1 1.000 0.002 MI:hsa-miR-801 mi 1 MI:hsa-miR-801 1 Q01995 380 4.56e-02 424 1 1 1.000 0.002 MI:hsa-miR-555 mi 1 MI:hsa-miR-555 1 Q01995 380 4.56e-02 424 1 1 1.000 0.002 MI:hsa-miR-151-5p mi 1 MI:hsa-miR-151-5p 1 Q01995 380 4.60e-02 428 1 1 1.000 0.002 MI:mmu-miR-666-3p mi 1 MI:mmu-miR-666-3p 1 Q01995 380 4.60e-02 428 1 1 1.000 0.002 MI:hsa-miR-936 mi 1 MI:hsa-miR-936 1 Q01995 380 4.66e-02 433 1 1 1.000 0.002 MI:hsa-miR-423-3p mi 1 MI:hsa-miR-423-3p 1 Q01995 380 4.67e-02 434 1 1 1.000 0.002 MI:hsa-miR-129-3p mi 1 MI:hsa-miR-129-3p 1 Q01995 380 4.70e-02 437 1 1 1.000 0.002 MI:hsa-miR-188-5p mi 1 MI:hsa-miR-188-5p 1 Q01995 380 4.71e-02 438 1 1 1.000 0.002 MI:hsa-miR-935 mi 1 MI:hsa-miR-935 1 Q01995 380 4.72e-02 439 1 1 1.000 0.002 MI:mmu-miR-699 mi 1 MI:mmu-miR-699 1 Q01995 380 4.74e-02 441 1 1 1.000 0.002 MI:hsa-miR-647 mi 1 MI:hsa-miR-647 1 Q01995 380 4.77e-02 444 1 1 1.000 0.002 MI:hsa-miR-554 mi 1 MI:hsa-miR-554 1 Q01995 380 4.83e-02 449 1 1 1.000 0.002 MI:hsa-miR-602 mi 1 MI:hsa-miR-602 1 Q01995 380 4.90e-02 456 1 1 1.000 0.002 MI:hsa-miR-542-3p mi 1 MI:hsa-miR-542-3p 1 Q01995 380 4.94e-02 459 1 1 1.000 0.002 MI:mmu-miR-762 mi 1 MI:mmu-miR-762 1 Q01995 380 5.00e-02 465 1 1 1.000 0.002 MI:hsa-miR-886-5p mi 1 MI:hsa-miR-886-5p 1 Q01995 380 5.00e-02 217 1 1 1.000 0.005 GO:0061061 BP 1 muscle structure development 1 Q01995 381 2.29e-03 610 2 2 1.000 0.003 TF:M03871_0 tf 1 Factor: GLI; motif: MCVNNGACCACCCAV; match class: 0 1 Q969T9,Q6PCE3 381 3.61e-03 23 2 1 0.500 0.043 TF:M00987_1 tf 1 Factor: FOXP1; motif: TTATTTGTRTTKKYTWKTWT; match class: 1 1 Q969T9 381 5.49e-03 35 2 1 0.500 0.029 TF:M04418_0 tf 1 Factor: OTX1; motif: NNTAATCCGATTANN; match class: 0 1 Q969T9 381 5.56e-03 1 2 1 0.500 1.000 GO:0071442 BP 1 positive regulation of histone H3-K14 acetylation 1 Q969T9 381 5.56e-03 1 2 1 0.500 1.000 GO:0047933 MF 1 glucose-1,6-bisphosphate synthase activity 1 Q6PCE3 381 7.37e-03 1093 2 2 1.000 0.002 TF:M06117_0 tf 1 Factor: ZNF23; motif: KGGKTGRGGAGG; match class: 0 1 Q969T9,Q6PCE3 381 8.62e-03 55 2 1 0.500 0.018 TF:M04420_0 tf 1 Factor: OTX2; motif: NNTAATCCGATTANN; match class: 0 1 Q969T9 381 9.25e-03 59 2 1 0.500 0.017 TF:M01657_1 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 1 1 Q969T9 381 1.07e-02 68 2 1 0.500 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 Q969T9 381 1.22e-02 78 2 1 0.500 0.013 TF:M07339_1 tf 1 Factor: Staf; motif: AMNTCCCAGAATGCCT; match class: 1 1 Q969T9 381 1.33e-02 85 2 1 0.500 0.012 TF:M00236_0 tf 1 Factor: Arnt; motif: NDDNNCACGTGNNNNN; match class: 0 1 Q6PCE3 381 1.52e-02 1572 2 2 1.000 0.001 TF:M03882_0 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 0 1 Q969T9,Q6PCE3 381 1.67e-02 3 2 1 0.500 0.333 GO:0071440 BP 1 regulation of histone H3-K14 acetylation 1 Q969T9 381 1.67e-02 107 2 1 0.500 0.009 TF:M04163_0 tf 1 Factor: BHLHE41; motif: NKCACGTGMC; match class: 0 1 Q6PCE3 381 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q969T9 381 1.68e-02 1648 2 2 1.000 0.001 TF:M00252_1 tf 1 Factor: TATA; motif: STATAAAWRNNNNNN; match class: 1 1 Q969T9,Q6PCE3 381 1.71e-02 1666 2 2 1.000 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q969T9,Q6PCE3 381 1.79e-02 1703 2 2 1.000 0.001 TF:M03835_0 tf 1 Factor: Nrf2; motif: ACNRTGACTCAGCANWA; match class: 0 1 Q969T9,Q6PCE3 381 1.92e-02 1764 2 2 1.000 0.001 TF:M04194_0 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 0 1 Q969T9,Q6PCE3 381 2.13e-02 1859 2 2 1.000 0.001 TF:M03860_1 tf 1 Factor: USF2; motif: NNNCCACGTGACN; match class: 1 1 Q969T9,Q6PCE3 381 2.22e-02 4 2 1 0.500 0.250 GO:0044154 BP 1 histone H3-K14 acetylation 1 Q969T9 381 2.23e-02 1901 2 2 1.000 0.001 TF:M04281_0 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 0 1 Q969T9,Q6PCE3 381 2.27e-02 1920 2 2 1.000 0.001 TF:M07292_1 tf 1 Factor: GLI; motif: NTGGGTGGTN; match class: 1 1 Q969T9,Q6PCE3 381 2.45e-02 1991 2 2 1.000 0.001 TF:M04307_0 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 0 1 Q969T9,Q6PCE3 381 2.48e-02 159 2 1 0.500 0.006 TF:M00940_1 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 1 Q969T9 381 2.59e-02 2050 2 2 1.000 0.001 TF:M04571_0 tf 1 Factor: TFEC; motif: RNCACRTGAY; match class: 0 1 Q969T9,Q6PCE3 381 2.68e-02 172 2 1 0.500 0.006 TF:M00006_1 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 1 1 Q6PCE3 381 2.93e-02 188 2 1 0.500 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q6PCE3 381 2.95e-02 189 2 1 0.500 0.005 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 Q969T9 381 3.13e-02 2251 2 2 1.000 0.001 TF:M06887_0 tf 1 Factor: MIZF; motif: WTGCGTG; match class: 0 1 Q969T9,Q6PCE3 381 3.14e-02 2256 2 2 1.000 0.001 TF:M04287_1 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 1 Q969T9,Q6PCE3 381 3.38e-02 217 2 1 0.500 0.005 TF:M04307_1 tf 1 Factor: DPRX; motif: NRGATAATCCN; match class: 1 1 Q969T9 381 3.55e-02 228 2 1 0.500 0.004 TF:M07084_0 tf 1 Factor: E2F-4; motif: NGGCGGGAARN; match class: 0 1 Q6PCE3 381 3.82e-02 2489 2 2 1.000 0.001 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 Q969T9,Q6PCE3 381 4.11e-02 264 2 1 0.500 0.004 TF:M00482_1 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 1 1 Q969T9 381 4.32e-02 278 2 1 0.500 0.004 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 Q969T9 381 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 Q969T9,Q6PCE3 381 4.43e-02 285 2 1 0.500 0.004 TF:M00257_0 tf 1 Factor: RREB-1; motif: CCCCAAACMMCCCC; match class: 0 1 Q6PCE3 381 4.80e-02 309 2 1 0.500 0.003 TF:M00919_1 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 1 1 Q969T9 381 4.85e-02 2804 2 2 1.000 0.001 TF:M04193_0 tf 1 Factor: TFE3; motif: NNCACGTGAY; match class: 0 1 Q969T9,Q6PCE3 381 4.89e-02 315 2 1 0.500 0.003 TF:M00740_1 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 1 Q969T9 381 5.00e-02 26 2 1 0.500 0.038 KEGG:00500 keg 1 Starch and sucrose metabolism 1 Q6PCE3 382 2.86e-11 123 7 6 0.857 0.049 GO:0032561 MF 1 guanyl ribonucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 3.01e-11 124 7 6 0.857 0.048 GO:0019001 MF 1 guanyl nucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.59e-08 349 7 6 0.857 0.017 GO:0032549 MF 1 ribonucleoside binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.59e-08 349 7 6 0.857 0.017 GO:0032550 MF 1 purine ribonucleoside binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.62e-08 350 7 6 0.857 0.017 GO:0001883 MF 1 purine nucleoside binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.70e-08 353 7 6 0.857 0.017 GO:0001882 MF 1 nucleoside binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.03e-08 44 7 4 0.571 0.091 GO:0019003 MF 1 GDP binding 1 Q15286,Q92930,P20338,Q6IQ22 382 2.12e-08 366 7 6 0.857 0.016 GO:0032555 MF 1 purine ribonucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.34e-08 372 7 6 0.857 0.016 GO:0032553 MF 1 ribonucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.57e-08 378 7 6 0.857 0.016 GO:0017076 MF 1 purine nucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.86e-08 522 7 7 1.000 0.013 REAC:199991 rea 1 Membrane Trafficking 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 2.95e-08 158 7 5 0.714 0.032 GO:0003924 MF 1 GTPase activity 1 Q15286,P51153,Q92930,P20338,P20340 382 4.07e-08 549 7 7 1.000 0.013 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 1.07e-07 479 7 6 0.857 0.013 GO:0000166 MF 1 nucleotide binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.08e-07 480 7 6 0.857 0.013 GO:1901265 MF 1 nucleoside phosphate binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.19e-07 540 7 6 0.857 0.011 GO:0097367 MF 1 carbohydrate derivative binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 4.62e-07 612 7 6 0.857 0.010 GO:0036094 MF 1 small molecule binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 6.27e-07 102 7 4 0.571 0.039 GO:0005525 MF 1 GTP binding 1 Q15286,P51153,P20338,P20340 382 2.76e-06 826 7 6 0.857 0.007 GO:0043168 MF 1 anion binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 4.92e-06 910 7 6 0.857 0.007 GO:0097708 CC 1 intracellular vesicle 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 5.24e-06 173 7 4 0.571 0.023 GO:0019882 BP 1 antigen processing and presentation 1 Q15286,Q92930,P20338,P20340 382 5.63e-06 931 7 6 0.857 0.006 GO:0031410 CC 1 cytoplasmic vesicle 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 1.42e-05 222 7 4 0.571 0.018 GO:0016197 BP 1 endosomal transport 1 Q15286,P51153,P20340,Q6IQ22 382 1.53e-05 553 7 5 0.714 0.009 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 Q15286,P51153,Q92930,P20338,P20340 382 2.10e-05 7 7 2 0.286 0.286 GO:0032593 CC 1 insulin-responsive compartment 1 P51153,P20338 382 2.11e-05 590 7 5 0.714 0.008 GO:0016462 MF 1 pyrophosphatase activity 1 Q15286,P51153,Q92930,P20338,P20340 382 2.14e-05 592 7 5 0.714 0.008 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Q15286,P51153,Q92930,P20338,P20340 382 2.14e-05 592 7 5 0.714 0.008 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 Q15286,P51153,Q92930,P20338,P20340 382 3.91e-05 1291 7 6 0.857 0.005 GO:0043167 MF 1 ion binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 6.58e-05 327 7 4 0.571 0.012 GO:0035639 MF 1 purine ribonucleoside triphosphate binding 1 Q15286,P51153,P20338,P20340 382 1.05e-04 2644 7 7 1.000 0.003 GO:0006810 BP 1 transport 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 1.36e-04 17 7 2 0.286 0.118 GO:0006904 BP 1 vesicle docking involved in exocytosis 1 P51153,Q92930 382 1.37e-04 2748 7 7 1.000 0.003 GO:0051234 BP 1 establishment of localization 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 2.26e-04 958 7 5 0.714 0.005 GO:0016192 BP 1 vesicle-mediated transport 1 Q15286,P51153,Q92930,P20338,P20340 382 2.65e-04 466 7 4 0.571 0.009 GO:0005768 CC 1 endosome 1 Q15286,P51153,P20338,Q6IQ22 382 3.10e-04 1836 7 6 0.857 0.003 GO:0051641 BP 1 cellular localization 1 Q15286,P51153,Q92930,P20340,P31150,Q6IQ22 382 3.23e-04 26 7 2 0.286 0.077 GO:0032456 BP 1 endocytic recycling 1 Q15286,P51153 382 4.03e-04 181 7 3 0.429 0.017 GO:0030139 CC 1 endocytic vesicle 1 Q15286,P51153,Q92930 382 4.64e-04 1111 7 5 0.714 0.005 GO:0034613 BP 1 cellular protein localization 1 Q15286,P51153,Q92930,P20340,P31150 382 4.84e-04 1121 7 5 0.714 0.004 GO:0070727 BP 1 cellular macromolecule localization 1 Q15286,P51153,Q92930,P20340,P31150 382 5.57e-04 34 7 2 0.286 0.059 GO:0048278 BP 1 vesicle docking 1 P51153,Q92930 382 6.12e-04 3401 7 7 1.000 0.002 GO:0051179 BP 1 localization 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 7.57e-04 224 7 3 0.429 0.013 GO:0099503 CC 1 secretory vesicle 1 P51153,P20338,P20340 382 7.79e-04 1237 7 5 0.714 0.004 GO:0046907 BP 1 intracellular transport 1 Q15286,Q92930,P20340,P31150,Q6IQ22 382 1.02e-03 46 7 2 0.286 0.043 GO:0022406 BP 1 membrane docking 1 P51153,Q92930 382 1.38e-03 1393 7 5 0.714 0.004 GO:0008104 BP 1 protein localization 1 Q15286,P51153,Q92930,P20340,P31150 382 1.48e-03 1414 7 5 0.714 0.004 GO:0031090 CC 1 organelle membrane 1 Q15286,P51153,Q92930,P20340,Q6IQ22 382 1.62e-03 290 7 3 0.429 0.010 GO:0090150 BP 1 establishment of protein localization to membrane 1 P51153,Q92930,P31150 382 1.87e-03 771 7 4 0.571 0.005 GO:1902580 BP 1 single-organism cellular localization 1 P51153,Q92930,P20340,P31150 382 1.92e-03 1493 7 5 0.714 0.003 GO:0051649 BP 1 establishment of localization in cell 1 Q15286,Q92930,P20340,P31150,Q6IQ22 382 1.93e-03 1 7 1 0.143 1.000 GO:0060008 BP 1 Sertoli cell differentiation 1 P51153 382 1.93e-03 1 7 1 0.143 1.000 GO:0060009 BP 1 Sertoli cell development 1 P51153 382 1.93e-03 1 7 1 0.143 1.000 GO:0018125 BP 1 peptidyl-cysteine methylation 1 P20340 382 1.93e-03 1 7 1 0.143 1.000 GO:0070381 CC 1 endosome to plasma membrane transport vesicle 1 P20340 382 1.93e-03 1 7 1 0.143 1.000 GO:0044795 BP 1 trans-Golgi network to recycling endosome transport 1 P51153 382 1.93e-03 1 7 1 0.143 1.000 GO:0097368 BP 1 establishment of Sertoli cell barrier 1 P51153 382 2.40e-03 2612 7 6 0.857 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.67e-03 2660 7 6 0.857 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 2.72e-03 1607 7 5 0.714 0.003 GO:0016787 MF 1 hydrolase activity 1 Q15286,P51153,Q92930,P20338,P20340 382 2.81e-03 1618 7 5 0.714 0.003 GO:0033036 BP 1 macromolecule localization 1 Q15286,P51153,Q92930,P20340,P31150 382 3.09e-03 80 7 2 0.286 0.025 GO:0055037 CC 1 recycling endosome 1 P51153,Q6IQ22 382 3.28e-03 369 7 3 0.429 0.008 GO:0072657 BP 1 protein localization to membrane 1 P51153,Q92930,P31150 382 3.55e-03 2795 7 6 0.857 0.002 GO:0031982 CC 1 vesicle 1 Q15286,P51153,Q92930,P20338,P20340,Q6IQ22 382 3.61e-03 57 7 2 0.286 0.035 REAC:1445148 rea 1 Translocation of GLUT4 to the plasma membrane 1 P51153,P20338 382 3.85e-03 2 7 1 0.143 0.500 GO:0005093 MF 1 Rab GDP-dissociation inhibitor activity 1 P31150 382 4.06e-03 945 7 4 0.571 0.004 GO:0098588 CC 1 bounding membrane of organelle 1 Q15286,Q92930,P20340,Q6IQ22 382 4.14e-03 400 7 3 0.429 0.007 GO:0031175 BP 1 neuron projection development 1 Q15286,P51153,P31150 382 4.38e-03 964 7 4 0.571 0.004 GO:0015031 BP 1 protein transport 1 P51153,Q92930,P20340,P31150 382 5.57e-03 443 7 3 0.429 0.007 GO:0048666 BP 1 neuron development 1 Q15286,P51153,P31150 382 5.77e-03 3 7 1 0.143 0.333 GO:0090315 BP 1 negative regulation of protein targeting to membrane 1 P31150 382 5.77e-03 3 7 1 0.143 0.333 GO:0072385 BP 1 minus-end-directed organelle transport along microtubule 1 P20340 382 7.10e-03 482 7 3 0.429 0.006 GO:0044431 CC 1 Golgi apparatus part 1 Q15286,P51153,P20340 382 7.21e-03 1100 7 4 0.571 0.004 GO:0045184 BP 1 establishment of protein localization 1 P51153,Q92930,P20340,P31150 382 7.31e-03 487 7 3 0.429 0.006 GO:0006605 BP 1 protein targeting 1 Q92930,P20340,P31150 382 7.69e-03 4 7 1 0.143 0.250 GO:0000042 BP 1 protein targeting to Golgi 1 P20340 382 7.84e-03 499 7 3 0.429 0.006 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q15286,P51153,Q6IQ22 382 8.34e-03 132 7 2 0.286 0.015 GO:0045216 BP 1 cell-cell junction organization 1 P51153,Q92930 382 8.95e-03 1165 7 4 0.571 0.003 GO:0002376 BP 1 immune system process 1 Q15286,Q92930,P20338,P20340 382 9.62e-03 5 7 1 0.143 0.200 GO:0032482 BP 1 Rab protein signal transduction 1 P31150 382 9.62e-03 5 7 1 0.143 0.200 GO:0045046 BP 1 protein import into peroxisome membrane 1 Q92930 382 9.68e-03 537 7 3 0.429 0.006 GO:0030182 BP 1 neuron differentiation 1 Q15286,P51153,P31150 382 1.03e-02 147 7 2 0.286 0.014 GO:0005802 CC 1 trans-Golgi network 1 P51153,P20340 382 1.14e-02 155 7 2 0.286 0.013 GO:0006612 BP 1 protein targeting to membrane 1 Q92930,P31150 382 1.15e-02 6 7 1 0.143 0.167 GO:0015919 BP 1 peroxisomal membrane transport 1 Q92930 382 1.16e-02 156 7 2 0.286 0.013 GO:0034330 BP 1 cell junction organization 1 P51153,Q92930 382 1.17e-02 574 7 3 0.429 0.005 GO:1902582 BP 1 single-organism intracellular transport 1 Q92930,P20340,P31150 382 1.17e-02 2194 7 5 0.714 0.002 GO:0070062 CC 1 extracellular exosome 1 Q15286,P51153,Q92930,P20338,P20340 382 1.20e-02 2205 7 5 0.714 0.002 GO:1903561 CC 1 extracellular vesicle 1 Q15286,P51153,Q92930,P20338,P20340 382 1.20e-02 2205 7 5 0.714 0.002 GO:0043230 CC 1 extracellular organelle 1 Q15286,P51153,Q92930,P20338,P20340 382 1.24e-02 586 7 3 0.429 0.005 GO:0048699 BP 1 generation of neurons 1 Q15286,P51153,P31150 382 1.26e-02 163 7 2 0.286 0.012 GO:0030141 CC 1 secretory granule 1 P51153,P20338 382 1.34e-02 2260 7 5 0.714 0.002 GO:0012505 CC 1 endomembrane system 1 Q15286,P51153,P20338,P20340,Q6IQ22 382 1.35e-02 7 7 1 0.143 0.143 GO:0072600 BP 1 establishment of protein localization to Golgi 1 P20340 382 1.35e-02 169 7 2 0.286 0.012 GO:0098791 CC 1 Golgi subcompartment 1 P51153,P20340 382 1.44e-02 618 7 3 0.429 0.005 GO:0022008 BP 1 neurogenesis 1 Q15286,P51153,P31150 382 1.53e-02 630 7 3 0.429 0.005 GO:0044802 BP 1 single-organism membrane organization 1 P51153,Q92930,P31150 382 1.54e-02 8 7 1 0.143 0.125 GO:0048227 BP 1 plasma membrane to endosome transport 1 Q15286 382 1.57e-02 182 7 2 0.286 0.011 GO:0031984 CC 1 organelle subcompartment 1 P51153,P20340 382 1.67e-02 1377 7 4 0.571 0.003 GO:0071702 BP 1 organic substance transport 1 P51153,Q92930,P20340,P31150 382 1.67e-02 650 7 3 0.429 0.005 GO:0030030 BP 1 cell projection organization 1 Q15286,P51153,P31150 382 1.72e-02 657 7 3 0.429 0.005 GO:0033365 BP 1 protein localization to organelle 1 Q15286,Q92930,P20340 382 1.73e-02 9 7 1 0.143 0.111 GO:0000301 BP 1 retrograde transport, vesicle recycling within Golgi 1 P20340 382 1.73e-02 9 7 1 0.143 0.111 GO:0005092 MF 1 GDP-dissociation inhibitor activity 1 P31150 382 1.86e-02 199 7 2 0.286 0.010 GO:0010008 CC 1 endosome membrane 1 Q15286,Q6IQ22 382 2.05e-02 209 7 2 0.286 0.010 GO:0009306 BP 1 protein secretion 1 P51153,Q92930 382 2.09e-02 5629 7 7 1.000 0.001 GO:0044444 CC 1 cytoplasmic part 1 Q15286,P51153,Q92930,P20338,P20340,P31150,Q6IQ22 382 2.11e-02 11 7 1 0.143 0.091 GO:1990089 BP 1 response to nerve growth factor 1 Q15286 382 2.11e-02 11 7 1 0.143 0.091 GO:1990090 BP 1 cellular response to nerve growth factor stimulus 1 Q15286 382 2.13e-02 709 7 3 0.429 0.004 GO:0006886 BP 1 intracellular protein transport 1 Q92930,P20340,P31150 382 2.27e-02 1498 7 4 0.571 0.003 GO:0044765 BP 1 single-organism transport 1 P51153,Q92930,P20340,P31150 382 2.30e-02 12 7 1 0.143 0.083 GO:0036010 BP 1 protein localization to endosome 1 Q15286 382 2.30e-02 12 7 1 0.143 0.083 GO:0034498 BP 1 early endosome to Golgi transport 1 P20340 382 2.41e-02 227 7 2 0.286 0.009 GO:0044440 CC 1 endosomal part 1 Q15286,Q6IQ22 382 2.48e-02 749 7 3 0.429 0.004 GO:0061024 BP 1 membrane organization 1 P51153,Q92930,P31150 382 2.50e-02 13 7 1 0.143 0.077 GO:0031489 MF 1 myosin V binding 1 P20340 382 2.58e-02 759 7 3 0.429 0.004 GO:0098805 CC 1 whole membrane 1 Q15286,Q92930,Q6IQ22 382 2.68e-02 2627 7 5 0.714 0.002 GO:0044421 CC 1 extracellular region part 1 Q15286,P51153,Q92930,P20338,P20340 382 2.69e-02 14 7 1 0.143 0.071 GO:0072663 BP 1 establishment of protein localization to peroxisome 1 Q92930 382 2.69e-02 14 7 1 0.143 0.071 GO:0006625 BP 1 protein targeting to peroxisome 1 Q92930 382 2.69e-02 14 7 1 0.143 0.071 GO:0072662 BP 1 protein localization to peroxisome 1 Q92930 382 2.75e-02 433 7 2 0.286 0.005 MI:hsa-miR-325 mi 1 MI:hsa-miR-325 1 P51153,P20338 382 2.77e-02 244 7 2 0.286 0.008 GO:0006887 BP 1 exocytosis 1 P51153,Q92930 382 2.88e-02 15 7 1 0.143 0.067 GO:0043574 BP 1 peroxisomal transport 1 Q92930 382 2.88e-02 15 7 1 0.143 0.067 GO:0090313 BP 1 regulation of protein targeting to membrane 1 P31150 382 2.88e-02 790 7 3 0.429 0.004 GO:0048468 BP 1 cell development 1 Q15286,P51153,P31150 382 3.07e-02 16 7 1 0.143 0.062 GO:0035767 BP 1 endothelial cell chemotaxis 1 P51153 382 3.07e-02 16 7 1 0.143 0.062 GO:0010737 BP 1 protein kinase A signaling 1 P51153 382 3.24e-02 1652 7 4 0.571 0.002 GO:1902578 BP 1 single-organism localization 1 P51153,Q92930,P20340,P31150 382 3.26e-02 2743 7 5 0.714 0.002 GO:0005576 CC 1 extracellular region 1 Q15286,P51153,Q92930,P20338,P20340 382 3.26e-02 17 7 1 0.143 0.059 GO:0030866 BP 1 cortical actin cytoskeleton organization 1 P51153 382 3.49e-02 846 7 3 0.429 0.004 GO:0005794 CC 1 Golgi apparatus 1 Q15286,P51153,P20340 382 3.56e-02 278 7 2 0.286 0.007 GO:0048193 BP 1 Golgi vesicle transport 1 Q15286,P20340 382 3.64e-02 19 7 1 0.143 0.053 GO:0018198 BP 1 peptidyl-cysteine modification 1 P20340 382 3.83e-02 20 7 1 0.143 0.050 GO:0034067 BP 1 protein localization to Golgi apparatus 1 P20340 382 3.83e-02 20 7 1 0.143 0.050 GO:1905476 BP 1 negative regulation of protein localization to membrane 1 P31150 382 3.83e-02 20 7 1 0.143 0.050 GO:0055038 CC 1 recycling endosome membrane 1 Q6IQ22 382 4.02e-02 21 7 1 0.143 0.048 GO:0030865 BP 1 cortical cytoskeleton organization 1 P51153 382 4.25e-02 2318 7 4 0.571 0.002 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 Q15286,P20340,P31150,Q6IQ22 382 4.40e-02 23 7 1 0.143 0.043 GO:0016328 CC 1 lateral plasma membrane 1 P51153 382 4.59e-02 24 7 1 0.143 0.042 GO:0046546 BP 1 development of primary male sexual characteristics 1 P51153 382 4.59e-02 24 7 1 0.143 0.042 GO:0007031 BP 1 peroxisome organization 1 Q92930 382 4.59e-02 24 7 1 0.143 0.042 GO:0008584 BP 1 male gonad development 1 P51153 382 4.71e-02 943 7 3 0.429 0.003 GO:0007399 BP 1 nervous system development 1 Q15286,P51153,P31150 382 4.97e-02 26 7 1 0.143 0.038 GO:0046661 BP 1 male sex differentiation 1 P51153 382 5.00e-02 115 7 2 0.286 0.017 TF:M07079_0 tf 1 Factor: Cdx-2; motif: NNGYMATAAAA; match class: 0 1 P20340,Q6IQ22 382 5.00e-02 229 7 2 0.286 0.009 KEGG:04144 keg 1 Endocytosis 1 Q15286,P20338 382 5.00e-02 18 7 1 0.143 0.056 REAC:1912420 rea 1 Pre-NOTCH Processing in Golgi 1 P20340 382 5.00e-02 332 7 2 0.286 0.006 GO:0000139 CC 1 Golgi membrane 1 Q15286,P20340 382 5.00e-02 1 7 1 0.143 1.000 OMIM:300849 omi 1 MENTAL RETARDATION, X-LINKED 41; MRX41;;MENTAL RETARDATION, X-LINKED 48; MRX48 1 P31150 383 4.61e-06 6 4 2 0.500 0.333 GO:0008179 MF 1 adenylate cyclase binding 1 P40123,Q01518 383 1.28e-05 9 4 2 0.500 0.222 REAC:428890 rea 1 Role of Abl in Robo-Slit signaling 1 P40123,Q01518 383 1.38e-05 117 4 3 0.750 0.026 GO:0008154 BP 1 actin polymerization or depolymerization 1 P40123,Q01518,P23528 383 6.40e-05 195 4 3 0.750 0.015 GO:0003779 MF 1 actin binding 1 P40123,Q01518,P23528 383 7.08e-05 22 4 2 0.500 0.091 GO:0007190 BP 1 activation of adenylate cyclase activity 1 P40123,Q01518 383 7.76e-05 23 4 2 0.500 0.087 GO:0045762 BP 1 positive regulation of adenylate cyclase activity 1 P40123,Q01518 383 8.23e-05 212 4 3 0.750 0.014 GO:0007015 BP 1 actin filament organization 1 P40123,Q01518,P23528 383 1.24e-04 29 4 2 0.500 0.069 GO:0031281 BP 1 positive regulation of cyclase activity 1 P40123,Q01518 383 1.24e-04 29 4 2 0.500 0.069 GO:0051349 BP 1 positive regulation of lyase activity 1 P40123,Q01518 383 1.33e-04 30 4 2 0.500 0.067 GO:0030819 BP 1 positive regulation of cAMP biosynthetic process 1 P40123,Q01518 383 1.42e-04 31 4 2 0.500 0.065 GO:0030816 BP 1 positive regulation of cAMP metabolic process 1 P40123,Q01518 383 1.52e-04 32 4 2 0.500 0.062 GO:0045761 BP 1 regulation of adenylate cyclase activity 1 P40123,Q01518 383 1.65e-04 31 4 2 0.500 0.065 REAC:376176 rea 1 Signaling by Robo receptor 1 P40123,Q01518 383 1.72e-04 34 4 2 0.500 0.059 GO:0030804 BP 1 positive regulation of cyclic nucleotide biosynthetic process 1 P40123,Q01518 383 1.93e-04 36 4 2 0.500 0.056 GO:0030810 BP 1 positive regulation of nucleotide biosynthetic process 1 P40123,Q01518 383 1.93e-04 36 4 2 0.500 0.056 GO:1900373 BP 1 positive regulation of purine nucleotide biosynthetic process 1 P40123,Q01518 383 2.04e-04 37 4 2 0.500 0.054 GO:0030801 BP 1 positive regulation of cyclic nucleotide metabolic process 1 P40123,Q01518 383 2.15e-04 38 4 2 0.500 0.053 GO:0031279 BP 1 regulation of cyclase activity 1 P40123,Q01518 383 2.39e-04 40 4 2 0.500 0.050 GO:0051339 BP 1 regulation of lyase activity 1 P40123,Q01518 383 2.51e-04 41 4 2 0.500 0.049 GO:0030864 CC 1 cortical actin cytoskeleton 1 P40123,Q01518 383 2.76e-04 43 4 2 0.500 0.047 GO:0030817 BP 1 regulation of cAMP biosynthetic process 1 P40123,Q01518 383 2.89e-04 44 4 2 0.500 0.045 GO:0006171 BP 1 cAMP biosynthetic process 1 P40123,Q01518 383 3.30e-04 47 4 2 0.500 0.043 GO:0030802 BP 1 regulation of cyclic nucleotide biosynthetic process 1 P40123,Q01518 383 3.45e-04 48 4 2 0.500 0.042 GO:0030814 BP 1 regulation of cAMP metabolic process 1 P40123,Q01518 383 3.59e-04 49 4 2 0.500 0.041 GO:0045981 BP 1 positive regulation of nucleotide metabolic process 1 P40123,Q01518 383 3.59e-04 49 4 2 0.500 0.041 GO:1900544 BP 1 positive regulation of purine nucleotide metabolic process 1 P40123,Q01518 383 3.74e-04 50 4 2 0.500 0.040 GO:0030863 CC 1 cortical cytoskeleton 1 P40123,Q01518 383 3.90e-04 51 4 2 0.500 0.039 GO:1900371 BP 1 regulation of purine nucleotide biosynthetic process 1 P40123,Q01518 383 3.95e-04 358 4 3 0.750 0.008 GO:0030036 BP 1 actin cytoskeleton organization 1 P40123,Q01518,P23528 383 4.05e-04 52 4 2 0.500 0.038 GO:0030808 BP 1 regulation of nucleotide biosynthetic process 1 P40123,Q01518 383 4.37e-04 54 4 2 0.500 0.037 GO:0052652 BP 1 cyclic purine nucleotide metabolic process 1 P40123,Q01518 383 4.54e-04 55 4 2 0.500 0.036 GO:0009190 BP 1 cyclic nucleotide biosynthetic process 1 P40123,Q01518 383 4.70e-04 56 4 2 0.500 0.036 GO:0030799 BP 1 regulation of cyclic nucleotide metabolic process 1 P40123,Q01518 383 4.70e-04 56 4 2 0.500 0.036 GO:0046058 BP 1 cAMP metabolic process 1 P40123,Q01518 383 6.31e-04 419 4 3 0.750 0.007 GO:0030029 BP 1 actin filament-based process 1 P40123,Q01518,P23528 383 7.36e-04 70 4 2 0.500 0.029 GO:0044448 CC 1 cell cortex part 1 P40123,Q01518 383 8.46e-04 75 4 2 0.500 0.027 GO:0009187 BP 1 cyclic nucleotide metabolic process 1 P40123,Q01518 383 9.17e-04 475 4 3 0.750 0.006 GO:0000902 BP 1 cell morphogenesis 1 P40123,Q01518,P23528 383 9.75e-04 485 4 3 0.750 0.006 GO:0008092 MF 1 cytoskeletal protein binding 1 P40123,Q01518,P23528 383 1.14e-03 87 4 2 0.500 0.023 GO:1900542 BP 1 regulation of purine nucleotide metabolic process 1 P40123,Q01518 383 1.17e-03 515 4 3 0.750 0.006 GO:0032989 BP 1 cellular component morphogenesis 1 P40123,Q01518,P23528 383 1.36e-03 95 4 2 0.500 0.021 GO:0006140 BP 1 regulation of nucleotide metabolic process 1 P40123,Q01518 383 1.50e-03 459 4 3 0.750 0.007 REAC:422475 rea 1 Axon guidance 1 P40123,Q01518,P23528 383 1.56e-03 102 4 2 0.500 0.020 GO:0007163 BP 1 establishment or maintenance of cell polarity 1 P40123,Q01518 383 1.70e-03 99 4 2 0.500 0.020 REAC:114608 rea 1 Platelet degranulation 1 Q01518,P23528 383 1.85e-03 111 4 2 0.500 0.018 GO:0009152 BP 1 purine ribonucleotide biosynthetic process 1 P40123,Q01518 383 1.87e-03 104 4 2 0.500 0.019 REAC:76005 rea 1 Response to elevated platelet cytosolic Ca2+ 1 Q01518,P23528 383 1.95e-03 114 4 2 0.500 0.018 GO:0009260 BP 1 ribonucleotide biosynthetic process 1 P40123,Q01518 383 1.99e-03 115 4 2 0.500 0.017 GO:0005938 CC 1 cell cortex 1 P40123,Q01518 383 1.99e-03 115 4 2 0.500 0.017 GO:0006164 BP 1 purine nucleotide biosynthetic process 1 P40123,Q01518 383 2.02e-03 116 4 2 0.500 0.017 GO:0046390 BP 1 ribose phosphate biosynthetic process 1 P40123,Q01518 383 2.24e-03 122 4 2 0.500 0.016 GO:0099568 CC 1 cytoplasmic region 1 P40123,Q01518 383 2.46e-03 128 4 2 0.500 0.016 GO:0072522 BP 1 purine-containing compound biosynthetic process 1 P40123,Q01518 383 2.70e-03 134 4 2 0.500 0.015 GO:0009165 BP 1 nucleotide biosynthetic process 1 P40123,Q01518 383 3.29e-03 148 4 2 0.500 0.014 GO:1901293 BP 1 nucleoside phosphate biosynthetic process 1 P40123,Q01518 383 3.66e-03 758 4 3 0.750 0.004 GO:0007010 BP 1 cytoskeleton organization 1 P40123,Q01518,P23528 383 5.61e-03 718 4 3 0.750 0.004 REAC:1266738 rea 1 Developmental Biology 1 P40123,Q01518,P23528 383 7.73e-03 213 4 2 0.500 0.009 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 Q01518,P23528 383 8.26e-03 7 4 1 0.250 0.143 GO:0044794 BP 1 positive regulation by host of viral process 1 P23528 383 8.62e-03 2 4 1 0.250 0.500 TF:M05589_0 tf 1 Factor: SALL2; motif: CRGTATACGGCCCC; match class: 0 1 P23528 383 1.12e-02 1107 4 3 0.750 0.003 GO:0009653 BP 1 anatomical structure morphogenesis 1 P40123,Q01518,P23528 383 1.30e-02 1168 4 3 0.750 0.003 GO:1902589 BP 1 single-organism organelle organization 1 P40123,Q01518,P23528 383 1.36e-02 303 4 2 0.500 0.007 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P40123,Q01518 383 1.37e-02 16 4 1 0.250 0.062 REAC:399954 rea 1 Sema3A PAK dependent Axon repulsion 1 P23528 383 1.38e-02 306 4 2 0.500 0.007 GO:0015629 CC 1 actin cytoskeleton 1 P40123,Q01518 383 1.39e-02 307 4 2 0.500 0.007 GO:0009259 BP 1 ribonucleotide metabolic process 1 P40123,Q01518 383 1.50e-02 319 4 2 0.500 0.006 GO:0019693 BP 1 ribose phosphate metabolic process 1 P40123,Q01518 383 1.55e-02 324 4 2 0.500 0.006 GO:0006163 BP 1 purine nucleotide metabolic process 1 P40123,Q01518 383 1.63e-02 333 4 2 0.500 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 Q01518,P23528 383 1.63e-02 333 4 2 0.500 0.006 GO:0005925 CC 1 focal adhesion 1 Q01518,P23528 383 1.64e-02 334 4 2 0.500 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 P40123,Q01518 383 1.65e-02 14 4 1 0.250 0.071 GO:0044788 BP 1 modulation by host of viral process 1 P23528 383 1.67e-02 337 4 2 0.500 0.006 GO:0030055 CC 1 cell-substrate junction 1 Q01518,P23528 383 1.80e-02 350 4 2 0.500 0.006 GO:0072521 BP 1 purine-containing compound metabolic process 1 P40123,Q01518 383 2.00e-02 17 4 1 0.250 0.059 GO:0061001 BP 1 regulation of dendritic spine morphogenesis 1 P23528 383 2.21e-02 388 4 2 0.500 0.005 GO:0009117 BP 1 nucleotide metabolic process 1 P40123,Q01518 383 2.32e-02 398 4 2 0.500 0.005 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P40123,Q01518 383 2.83e-02 24 4 1 0.250 0.042 GO:0060997 BP 1 dendritic spine morphogenesis 1 P23528 383 2.95e-02 450 4 2 0.500 0.004 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P40123,Q01518 383 3.00e-02 803 4 2 0.500 0.002 HPA:041010_03 hpa 1 spleen; cells in red pulp[Uncertain,High] 1 Q01518,P23528 383 3.15e-02 466 4 2 0.500 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 P40123,Q01518 383 3.18e-02 27 4 1 0.250 0.037 GO:0030042 BP 1 actin filament depolymerization 1 P23528 383 3.18e-02 27 4 1 0.250 0.037 GO:0060998 BP 1 regulation of dendritic spine development 1 P23528 383 3.22e-02 444 4 2 0.500 0.005 REAC:109582 rea 1 Hemostasis 1 Q01518,P23528 383 3.26e-02 840 4 2 0.500 0.002 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 Q01518,P23528 383 3.32e-02 39 4 1 0.250 0.026 REAC:3928662 rea 1 EPHB-mediated forward signaling 1 P23528 383 3.41e-02 263 4 2 0.500 0.008 TF:M05883_1 tf 1 Factor: ZNF709; motif: NGRWCCAAACCC; match class: 1 1 P40123,P23528 383 3.41e-02 29 4 1 0.250 0.034 GO:0097061 BP 1 dendritic spine organization 1 P23528 383 3.55e-02 1649 4 3 0.750 0.002 GO:0048869 BP 1 cellular developmental process 1 P40123,Q01518,P23528 383 4.00e-02 34 4 1 0.250 0.029 GO:0003755 MF 1 peptidyl-prolyl cis-trans isomerase activity 1 F5H284 383 4.03e-02 529 4 2 0.500 0.004 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 P40123,Q01518 383 4.03e-02 529 4 2 0.500 0.004 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 P40123,Q01518 383 4.12e-02 35 4 1 0.250 0.029 GO:0051851 BP 1 modification by host of symbiont morphology or physiology 1 P23528 383 4.12e-02 35 4 1 0.250 0.029 GO:0016859 MF 1 cis-trans isomerase activity 1 F5H284 383 4.12e-02 35 4 1 0.250 0.029 GO:0060996 BP 1 dendritic spine development 1 P23528 383 4.12e-02 35 4 1 0.250 0.029 GO:0048814 BP 1 regulation of dendrite morphogenesis 1 P23528 383 4.12e-02 53 4 1 0.250 0.019 KEGG:05133 keg 1 Pertussis 1 P23528 383 4.23e-02 36 4 1 0.250 0.028 GO:0051702 BP 1 interaction with symbiont 1 P23528 383 4.74e-02 11 4 1 0.250 0.091 TF:M06933_0 tf 1 Factor: Smad6; motif: TTGSCCGCCWTA; match class: 0 1 P40123 383 4.85e-02 582 4 2 0.500 0.003 GO:0005912 CC 1 adherens junction 1 Q01518,P23528 383 5.00e-02 1267 4 3 0.750 0.002 TF:M07242_0 tf 1 Factor: AML1; motif: NNACCACAN; match class: 0 1 P40123,Q01518,F5H284 383 5.00e-02 59 4 1 0.250 0.017 REAC:2029482 rea 1 Regulation of actin dynamics for phagocytic cup formation 1 P23528 383 5.00e-02 3 4 2 0.500 0.667 CORUM:2255 cor 1 Cofilin-actin-CAP1 complex 1 Q01518,P23528 383 5.00e-02 591 4 2 0.500 0.003 GO:0070161 CC 1 anchoring junction 1 Q01518,P23528 383 5.00e-02 59 4 1 0.250 0.017 REAC:373755 rea 1 Semaphorin interactions 1 P23528 384 6.65e-07 42 4 3 0.750 0.071 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P09622,P82909,Q9ULD0 384 2.01e-06 4 4 2 0.500 0.500 GO:0045252 CC 1 oxoglutarate dehydrogenase complex 1 P82909,Q9ULD0 384 2.01e-06 4 4 2 0.500 0.500 GO:0004591 MF 1 oxoglutarate dehydrogenase (succinyl-transferring) activity 1 P82909,Q9ULD0 384 4.40e-06 78 4 3 0.750 0.038 GO:1990204 CC 1 oxidoreductase complex 1 P09622,P82909,Q9ULD0 384 9.38e-06 8 4 2 0.500 0.250 GO:0045240 CC 1 dihydrolipoyl dehydrogenase complex 1 P82909,Q9ULD0 384 9.38e-06 8 4 2 0.500 0.250 GO:0016624 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 1 P82909,Q9ULD0 384 9.38e-06 8 4 2 0.500 0.250 GO:0045239 CC 1 tricarboxylic acid cycle enzyme complex 1 P82909,Q9ULD0 384 9.23e-05 24 4 2 0.500 0.083 GO:0006099 BP 1 tricarboxylic acid cycle 1 P09622,Q9ULD0 384 1.26e-04 28 4 2 0.500 0.071 GO:0006101 BP 1 citrate metabolic process 1 P09622,Q9ULD0 384 1.66e-04 32 4 2 0.500 0.062 GO:0072350 BP 1 tricarboxylic acid metabolic process 1 P09622,Q9ULD0 384 2.34e-04 1029 4 4 1.000 0.004 GO:0005739 CC 1 mitochondrion 1 P09622,P82909,Q8N3R3,Q9ULD0 384 3.26e-04 29 4 2 0.500 0.069 KEGG:00020 keg 1 Citrate cycle (TCA cycle) 1 P09622,Q9ULD0 384 3.76e-04 48 4 2 0.500 0.042 GO:0009060 BP 1 aerobic respiration 1 P09622,Q9ULD0 384 1.03e-03 480 4 3 0.750 0.006 GO:0016491 MF 1 oxidoreductase activity 1 P09622,P82909,Q9ULD0 384 1.29e-03 1 4 1 0.250 1.000 GO:0009353 CC 1 mitochondrial oxoglutarate dehydrogenase complex 1 P82909 384 1.29e-03 1 4 1 0.250 1.000 GO:0004148 MF 1 dihydrolipoyl dehydrogenase activity 1 P09622 384 2.23e-03 909 4 3 0.750 0.003 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 P09622,P82909,Q9ULD0 384 2.54e-03 650 4 3 0.750 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 P09622,P82909,Q9ULD0 384 2.77e-03 130 4 2 0.500 0.015 GO:0045333 BP 1 cellular respiration 1 P09622,Q9ULD0 384 3.56e-03 729 4 3 0.750 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 P09622,P82909,Q9ULD0 384 3.71e-03 739 4 3 0.750 0.004 GO:0006082 BP 1 organic acid metabolic process 1 P09622,P82909,Q9ULD0 384 3.75e-03 275 4 2 0.500 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 P09622,P82909 384 3.86e-03 3 4 1 0.250 0.333 GO:0061732 BP 1 mitochondrial acetyl-CoA biosynthetic process from pyruvate 1 P09622 384 4.39e-03 4 4 1 0.250 0.250 REAC:6783984 rea 1 Glycine degradation 1 P09622 384 4.47e-03 107 4 2 0.500 0.019 KEGG:01200 keg 1 Carbon metabolism 1 P09622,Q9ULD0 384 4.53e-03 314 4 2 0.500 0.006 MI:hsa-miR-425* mi 1 MI:hsa-miR-425* 1 P09622,P82909 384 5.15e-03 4 4 1 0.250 0.250 GO:0034604 MF 1 pyruvate dehydrogenase (NAD+) activity 1 P09622 384 5.15e-03 4 4 1 0.250 0.250 GO:0034603 MF 1 pyruvate dehydrogenase [NAD(P)+] activity 1 P09622 384 5.30e-03 340 4 2 0.500 0.006 MI:mmu-miR-694 mi 1 MI:mmu-miR-694 1 P09622,Q8N3R3 384 5.35e-03 181 4 2 0.500 0.011 GO:0015980 BP 1 energy derivation by oxidation of organic compounds 1 P09622,Q9ULD0 384 6.06e-03 351 4 2 0.500 0.006 HPA:004030_13 hpa 1 breast; myoepithelial cells[Supportive,High] 1 P09622,P82909 384 6.44e-03 5 4 1 0.250 0.200 GO:0005947 CC 1 mitochondrial alpha-ketoglutarate dehydrogenase complex 1 P82909 384 6.44e-03 5 4 1 0.250 0.200 GO:0030062 CC 1 mitochondrial tricarboxylic acid cycle enzyme complex 1 P82909 384 6.45e-03 376 4 2 0.500 0.005 MI:mmu-miR-687 mi 1 MI:mmu-miR-687 1 P09622,Q9ULD0 384 7.73e-03 6 4 1 0.250 0.167 GO:0004738 MF 1 pyruvate dehydrogenase activity 1 P09622 384 7.73e-03 6 4 1 0.250 0.167 GO:0045254 CC 1 pyruvate dehydrogenase complex 1 P09622 384 8.13e-03 408 4 2 0.500 0.005 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 P09622,P82909 384 9.20e-03 451 4 2 0.500 0.004 MI:hsa-miR-892b mi 1 MI:hsa-miR-892b 1 P09622,Q9ULD0 384 9.93e-03 1033 4 3 0.750 0.003 GO:1902494 CC 1 catalytic complex 1 P09622,P82909,Q9ULD0 384 1.06e-02 2705 4 4 1.000 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 P09622,P82909,Q8N3R3,Q9ULD0 384 1.07e-02 257 4 2 0.500 0.008 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P09622,Q9ULD0 384 1.10e-02 476 4 2 0.500 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P09622,P82909 384 1.13e-02 484 4 2 0.500 0.004 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P09622,P82909 384 1.16e-02 9 4 1 0.250 0.111 GO:0016668 MF 1 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1 P09622 384 1.31e-02 12 4 1 0.250 0.083 REAC:71064 rea 1 Lysine catabolism 1 P09622 384 1.36e-02 531 4 2 0.500 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 P09622,P82909 384 1.41e-02 541 4 2 0.500 0.004 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 P09622,P82909 384 1.43e-02 1722 4 3 0.750 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P09622,P82909,Q9ULD0 384 1.52e-02 564 4 2 0.500 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 P09622,P82909 384 1.53e-02 14 4 1 0.250 0.071 REAC:204174 rea 1 Regulation of pyruvate dehydrogenase (PDH) complex 1 P09622 384 1.54e-02 12 4 1 0.250 0.083 GO:0006554 BP 1 lysine catabolic process 1 P09622 384 1.54e-02 12 4 1 0.250 0.083 GO:0050812 BP 1 regulation of acyl-CoA biosynthetic process 1 P09622 384 1.54e-02 12 4 1 0.250 0.083 GO:0010510 BP 1 regulation of acetyl-CoA biosynthetic process from pyruvate 1 P09622 384 1.54e-02 12 4 1 0.250 0.083 GO:0006086 BP 1 acetyl-CoA biosynthetic process from pyruvate 1 P09622 384 1.66e-02 589 4 2 0.500 0.003 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 P09622,P82909 384 1.67e-02 13 4 1 0.250 0.077 GO:0006103 BP 1 2-oxoglutarate metabolic process 1 P82909 384 1.67e-02 13 4 1 0.250 0.077 GO:0006553 BP 1 lysine metabolic process 1 P09622 384 1.81e-02 616 4 2 0.500 0.003 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 P09622,P82909 384 1.81e-02 3093 4 4 1.000 0.001 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 P09622,P82909,Q8N3R3,Q9ULD0 384 1.85e-02 624 4 2 0.500 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P09622,P82909 384 1.86e-02 625 4 2 0.500 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 P09622,P82909 384 1.90e-02 344 4 2 0.500 0.006 GO:0005759 CC 1 mitochondrial matrix 1 P09622,P82909 384 1.97e-02 18 4 1 0.250 0.056 REAC:71403 rea 1 Citric acid cycle (TCA cycle) 1 P09622 384 2.02e-02 653 4 2 0.500 0.003 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 P09622,P82909 384 2.02e-02 653 4 2 0.500 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P09622,P82909 384 2.06e-02 16 4 1 0.250 0.062 GO:0006085 BP 1 acetyl-CoA biosynthetic process 1 P09622 384 2.09e-02 1333 4 3 0.750 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P09622,P82909,Q9ULD0 384 2.15e-02 674 4 2 0.500 0.003 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 P09622,P82909 384 2.19e-02 17 4 1 0.250 0.059 GO:0042762 BP 1 regulation of sulfur metabolic process 1 P09622 384 2.25e-02 375 4 2 0.500 0.005 GO:0055114 BP 1 oxidation-reduction process 1 P09622,Q9ULD0 384 2.31e-02 18 4 1 0.250 0.056 GO:0009068 BP 1 aspartate family amino acid catabolic process 1 P09622 384 2.39e-02 713 4 2 0.500 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P09622,P82909 384 2.44e-02 2079 4 3 0.750 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 P09622,P82909,Q9ULD0 384 2.51e-02 23 4 1 0.250 0.043 REAC:70895 rea 1 Branched-chain amino acid catabolism 1 P09622 384 2.57e-02 20 4 1 0.250 0.050 GO:0009083 BP 1 branched-chain amino acid catabolic process 1 P09622 384 2.62e-02 24 4 1 0.250 0.042 REAC:389661 rea 1 Glyoxylate metabolism and glycine degradation 1 P09622 384 2.71e-02 761 4 2 0.500 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P09622,P82909 384 2.83e-02 22 4 1 0.250 0.045 GO:0009081 BP 1 branched-chain amino acid metabolic process 1 P09622 384 2.83e-02 22 4 1 0.250 0.045 GO:0006084 BP 1 acetyl-CoA metabolic process 1 P09622 384 2.84e-02 26 4 1 0.250 0.038 REAC:70268 rea 1 Pyruvate metabolism 1 P09622 384 2.95e-02 23 4 1 0.250 0.043 GO:0005763 CC 1 mitochondrial small ribosomal subunit 1 P82909 384 2.95e-02 23 4 1 0.250 0.043 GO:0000314 CC 1 organellar small ribosomal subunit 1 P82909 384 2.96e-02 798 4 2 0.500 0.003 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P09622,P82909 384 3.10e-02 19 4 1 0.250 0.053 TF:M06862_0 tf 1 Factor: ZNF671; motif: AWGKTCAGACMA; match class: 0 1 Q8N3R3 384 3.21e-02 25 4 1 0.250 0.040 GO:0046487 BP 1 glyoxylate metabolic process 1 P09622 384 3.23e-02 836 4 2 0.500 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P09622,P82909 384 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P09622,P82909 384 3.50e-02 871 4 2 0.500 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P09622,P82909 384 3.59e-02 3668 4 4 1.000 0.001 TF:M00698_0 tf 1 Factor: HEB; motif: RCCWGCTG; match class: 0 1 P09622,P82909,Q8N3R3,Q9ULD0 384 3.60e-02 443 4 2 0.500 0.005 TF:M07406_0 tf 1 Factor: SREBP-2; motif: RTGGGGTGAY; match class: 0 1 P82909,Q9ULD0 384 3.61e-02 1581 4 3 0.750 0.002 TF:M04108_0 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 0 1 P82909,Q8N3R3,Q9ULD0 384 3.66e-02 27 4 1 0.250 0.037 KEGG:00630 keg 1 Glyoxylate and dicarboxylate metabolism 1 P09622 384 3.70e-02 34 4 1 0.250 0.029 REAC:5362517 rea 1 Signaling by Retinoic Acid 1 P09622 384 3.72e-02 29 4 1 0.250 0.034 GO:0016620 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1 P09622 384 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P09622,P82909 384 3.93e-02 927 4 2 0.500 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 P09622,P82909 384 4.03e-02 37 4 1 0.250 0.027 REAC:6788656 rea 1 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 1 P09622 384 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 P09622,P82909 384 4.06e-02 30 4 1 0.250 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 Q9ULD0 384 4.08e-02 945 4 2 0.500 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 P09622,P82909 384 4.20e-02 31 4 1 0.250 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P09622 384 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P09622,P82909 384 4.24e-02 26 4 1 0.250 0.038 TF:M05364_0 tf 1 Factor: OZF; motif: NSGTCAAKAATC; match class: 0 1 Q9ULD0 384 4.24e-02 26 4 1 0.250 0.038 TF:M06260_0 tf 1 Factor: ZNF91; motif: GTKAAGCCRM; match class: 0 1 P09622 384 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P09622,P82909 384 4.34e-02 977 4 2 0.500 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P09622,P82909 384 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P09622,P82909 384 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P09622,P82909 384 4.78e-02 512 4 2 0.500 0.004 TF:M07405_0 tf 1 Factor: SREBP-1; motif: RTCACCCCAY; match class: 0 1 P82909,Q9ULD0 384 5.00e-02 39 4 1 0.250 0.026 GO:0051193 BP 1 regulation of cofactor metabolic process 1 P09622 384 5.00e-02 1 4 1 0.250 1.000 OMIM:246900 omi 1 DIHYDROLIPOAMIDE DEHYDROGENASE DEFICIENCY; DLDD;;DLD DEFICIENCY;;E3 DEFICIENCY;;LIPOAMIDE DEHYDROGENASE DEFICIENCY, LACTIC ACIDOSIS DUE TO;;MAPLE SYRUP URINE DISEASE, TYPE III 1 P09622 384 5.00e-02 37 4 1 0.250 0.027 KEGG:00260 keg 1 Glycine, serine and threonine metabolism 1 P09622 384 5.00e-02 39 4 1 0.250 0.026 GO:0051196 BP 1 regulation of coenzyme metabolic process 1 P09622 384 5.00e-02 524 4 2 0.500 0.004 TF:M00690_1 tf 1 Factor: AP-3; motif: TCYMMATT; match class: 1 1 P82909,Q8N3R3 384 5.00e-02 46 4 1 0.250 0.022 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 P09622 384 5.00e-02 29 4 1 0.250 0.034 CORUM:315 cor 1 28S ribosomal subunit, mitochondrial 1 P82909 385 6.99e-05 30 3 2 0.667 0.067 GO:0007157 BP 1 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 1 Q15223,Q9NQS3 385 9.01e-05 34 3 2 0.667 0.059 GO:0007156 BP 1 homophilic cell adhesion via plasma membrane adhesion molecules 1 Q15223,Q9NQS3 385 1.73e-04 6 3 2 0.667 0.333 REAC:420597 rea 1 Nectin/Necl trans heterodimerization 1 Q15223,Q9NQS3 385 2.74e-04 59 3 2 0.667 0.034 GO:0008037 BP 1 cell recognition 1 Q15223,Q9NQS3 385 4.21e-04 73 3 2 0.667 0.027 GO:0034332 BP 1 adherens junction organization 1 Q15223,Q9NQS3 385 4.56e-04 76 3 2 0.667 0.026 GO:0098742 BP 1 cell-cell adhesion via plasma-membrane adhesion molecules 1 Q15223,Q9NQS3 385 1.12e-03 1 3 1 0.333 1.000 HP:0002296 hp 1 Progressive hypotrichosis 1 Q15223 385 1.38e-03 132 3 2 0.667 0.015 GO:0045216 BP 1 cell-cell junction organization 1 Q15223,Q9NQS3 385 1.57e-03 17 3 2 0.667 0.118 REAC:418990 rea 1 Adherens junctions interactions 1 Q15223,Q9NQS3 385 1.93e-03 156 3 2 0.667 0.013 GO:0034330 BP 1 cell junction organization 1 Q15223,Q9NQS3 385 4.35e-03 28 3 2 0.667 0.071 REAC:421270 rea 1 Cell-cell junction organization 1 Q15223,Q9NQS3 385 5.57e-03 5 3 1 0.333 0.200 HP:0010621 hp 1 Cutaneous syndactyly of toes 1 Q15223 385 6.81e-03 294 3 2 0.667 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 Q15223,Q9NQS3 385 7.42e-03 8 3 1 0.333 0.125 GO:0001917 CC 1 photoreceptor inner segment 1 P20794 385 8.91e-03 8 3 1 0.333 0.125 HP:0000674 hp 1 Anodontia 1 Q15223 385 1.07e-02 369 3 2 0.667 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 Q15223,Q9NQS3 385 1.19e-02 389 3 2 0.667 0.005 GO:0098609 BP 1 cell-cell adhesion 1 Q15223,Q9NQS3 385 1.22e-02 11 3 1 0.333 0.091 HP:0005338 hp 1 Sparse lateral eyebrow 1 Q15223 385 1.38e-02 420 3 2 0.667 0.005 GO:0005911 CC 1 cell-cell junction 1 Q15223,Q9NQS3 385 1.44e-02 13 3 1 0.333 0.077 HP:0003777 hp 1 Pili torti 1 Q15223 385 1.48e-02 16 3 1 0.333 0.062 GO:0001750 CC 1 photoreceptor outer segment 1 P20794 385 1.52e-02 52 3 2 0.667 0.038 REAC:446728 rea 1 Cell junction organization 1 Q15223,Q9NQS3 385 1.55e-02 445 3 2 0.667 0.004 GO:0042803 MF 1 protein homodimerization activity 1 Q15223,Q9NQS3 385 1.57e-02 17 3 1 0.333 0.059 GO:0045494 BP 1 photoreceptor cell maintenance 1 P20794 385 1.76e-02 19 3 1 0.333 0.053 GO:0015026 MF 1 coreceptor activity 1 Q15223 385 2.00e-02 18 3 1 0.333 0.056 HP:0000968 hp 1 Ectodermal dysplasia 1 Q15223 385 2.33e-02 21 3 1 0.333 0.048 HP:0003328 hp 1 Abnormal hair laboratory examination 1 Q15223 385 2.44e-02 560 3 2 0.667 0.004 GO:0046983 MF 1 protein dimerization activity 1 Q15223,Q9NQS3 385 2.47e-02 329 3 2 0.667 0.006 MI:hsa-miR-19b-1* mi 1 MI:hsa-miR-19b-1* 1 Q15223,P20794 385 2.55e-02 23 3 1 0.333 0.043 HP:0001006 hp 1 Hypotrichosis 1 Q15223 385 2.63e-02 582 3 2 0.667 0.003 GO:0005912 CC 1 adherens junction 1 Q15223,Q9NQS3 385 2.68e-02 29 3 1 0.333 0.034 GO:0097733 CC 1 photoreceptor cell cilium 1 P20794 385 2.71e-02 591 3 2 0.667 0.003 GO:0070161 CC 1 anchoring junction 1 Q15223,Q9NQS3 385 2.76e-02 267 3 2 0.667 0.007 HP:0000431 hp 1 Wide nasal bridge 1 Q15223,P20794 385 2.78e-02 30 3 1 0.333 0.033 GO:0097732 CC 1 9+2 non-motile cilium 1 P20794 385 2.87e-02 609 3 2 0.667 0.003 GO:0060089 MF 1 molecular transducer activity 1 Q15223,Q9NQS3 385 2.87e-02 609 3 2 0.667 0.003 GO:0004872 MF 1 receptor activity 1 Q15223,Q9NQS3 385 3.24e-02 647 3 2 0.667 0.003 GO:0042802 MF 1 identical protein binding 1 Q15223,Q9NQS3 385 3.27e-02 650 3 2 0.667 0.003 GO:0051704 BP 1 multi-organism process 1 Q15223,P20794 385 3.33e-02 36 3 1 0.333 0.028 GO:0046718 BP 1 viral entry into host cell 1 Q15223 385 3.53e-02 32 3 1 0.333 0.031 HP:0010554 hp 1 Cutaneous finger syndactyly 1 Q15223 385 3.55e-02 678 3 2 0.667 0.003 GO:0007155 BP 1 cell adhesion 1 Q15223,Q9NQS3 385 3.60e-02 398 3 2 0.667 0.005 MI:hsa-miR-938 mi 1 MI:hsa-miR-938 1 Q15223,P20794 385 3.61e-02 39 3 1 0.333 0.026 GO:0051828 BP 1 entry into other organism involved in symbiotic interaction 1 Q15223 385 3.61e-02 39 3 1 0.333 0.026 GO:0044409 BP 1 entry into host 1 Q15223 385 3.61e-02 39 3 1 0.333 0.026 GO:0051806 BP 1 entry into cell of other organism involved in symbiotic interaction 1 Q15223 385 3.61e-02 39 3 1 0.333 0.026 GO:0030260 BP 1 entry into host cell 1 Q15223 385 3.61e-02 684 3 2 0.667 0.003 GO:0022610 BP 1 biological adhesion 1 Q15223,Q9NQS3 385 3.79e-02 41 3 1 0.333 0.024 GO:0097730 CC 1 non-motile cilium 1 P20794 385 3.86e-02 35 3 1 0.333 0.029 HP:0012725 hp 1 Cutaneous syndactyly 1 Q15223 385 3.96e-02 322 3 2 0.667 0.006 HP:0000050 hp 1 Hypoplastic male external genitalia 1 Q15223,P20794 385 3.97e-02 36 3 1 0.333 0.028 HP:0000972 hp 1 Palmoplantar hyperkeratosis 1 Q15223 385 3.97e-02 43 3 1 0.333 0.023 GO:0072686 CC 1 mitotic spindle 1 P20794 385 3.97e-02 43 3 1 0.333 0.023 GO:0001895 BP 1 retina homeostasis 1 P20794 385 4.08e-02 37 3 1 0.333 0.027 HP:0000046 hp 1 Scrotal hypoplasia 1 Q15223 385 4.11e-02 731 3 2 0.667 0.003 GO:0005102 MF 1 receptor binding 1 Q15223,Q9NQS3 385 4.12e-02 329 3 2 0.667 0.006 HP:0002205 hp 1 Recurrent respiratory infections 1 Q15223,P20794 385 4.18e-02 38 3 1 0.333 0.026 HP:0010765 hp 1 Palmar hyperkeratosis 1 Q15223 385 4.28e-02 746 3 2 0.667 0.003 GO:0030054 CC 1 cell junction 1 Q15223,Q9NQS3 385 4.29e-02 336 3 2 0.667 0.006 HP:0003241 hp 1 External genital hypoplasia 1 Q15223,P20794 385 4.47e-02 70 3 2 0.667 0.029 KEGG:04520 keg 1 Adherens junction 1 Q15223,Q9NQS3 385 4.53e-02 447 3 2 0.667 0.004 MI:hsa-miR-18b mi 1 MI:hsa-miR-18b 1 Q15223,P20794 385 4.62e-02 42 3 1 0.333 0.024 HP:0007556 hp 1 Plantar hyperkeratosis 1 Q15223 385 4.62e-02 42 3 1 0.333 0.024 HP:0000966 hp 1 Hypohidrosis 1 Q15223 385 4.83e-02 44 3 1 0.333 0.023 HP:0000653 hp 1 Sparse eyelashes 1 Q15223 385 4.96e-02 468 3 2 0.667 0.004 MI:hsa-miR-802 mi 1 MI:hsa-miR-802 1 Q15223,P20794 385 5.00e-02 751 3 3 1.000 0.004 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 Q15223,P20794,Q9NQS3 385 5.00e-02 1 3 1 0.333 1.000 OMIM:614181 omi 1 RETINITIS PIGMENTOSA 62; RP62 1 P20794 385 5.00e-02 94 3 2 0.667 0.021 REAC:1500931 rea 1 Cell-Cell communication 1 Q15223,Q9NQS3 385 5.00e-02 1 3 1 0.333 1.000 OMIM:225060 omi 1 CLEFT LIP/PALATE-ECTODERMAL DYSPLASIA SYNDROME; CLPED1;;ZLOTOGORA-OGUR SYNDROME;;ECTODERMAL DYSPLASIA, MARGARITA ISLAND TYPE;;ECTODERMAL DYSPLASIA, TYPE 4; ED4;;ECTODERMAL DYSPLASIA, CLEFT LIP AND PALATE, MENTAL RETARDATION, ANDSYNDACTYLYOROFACIAL CLEFT 7, INCLUDED; OFC7, INCLUDED;;CLEFT LIP WITH OR WITHOUT CLEFT PALATE, NONSYNDROMIC, 7, INCLUDED 1 Q15223 385 5.00e-02 470 3 2 0.667 0.004 MI:hsa-miR-18a mi 1 MI:hsa-miR-18a 1 Q15223,P20794 386 1.76e-10 18 5 4 0.800 0.222 REAC:71403 rea 1 Citric acid cycle (TCA cycle) 1 P51553,O43837,Q9P2R7,P50213 386 3.61e-10 24 5 4 0.800 0.167 GO:0006099 BP 1 tricarboxylic acid cycle 1 P51553,O43837,Q9P2R7,P50213 386 6.96e-10 28 5 4 0.800 0.143 GO:0006101 BP 1 citrate metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 1.22e-09 32 5 4 0.800 0.125 GO:0072350 BP 1 tricarboxylic acid metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 6.60e-09 48 5 4 0.800 0.083 GO:0009060 BP 1 aerobic respiration 1 P51553,O43837,Q9P2R7,P50213 386 7.16e-09 29 5 4 0.800 0.138 KEGG:00020 keg 1 Citrate cycle (TCA cycle) 1 P51553,O43837,Q9P2R7,P50213 386 9.37e-09 46 5 4 0.800 0.087 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 P51553,O43837,Q9P2R7,P50213 386 3.83e-07 130 5 4 0.800 0.031 GO:0045333 BP 1 cellular respiration 1 P51553,O43837,Q9P2R7,P50213 386 5.18e-07 17 5 3 0.600 0.176 KEGG:01210 keg 1 2-Oxocarboxylic acid metabolism 1 P51553,O43837,P50213 386 7.55e-07 2 5 2 0.400 1.000 GO:0004449 MF 1 isocitrate dehydrogenase (NAD+) activity 1 P51553,O43837 386 1.25e-06 153 5 4 0.800 0.026 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P51553,O43837,Q9P2R7,P50213 386 1.45e-06 181 5 4 0.800 0.022 GO:0015980 BP 1 energy derivation by oxidation of organic compounds 1 P51553,O43837,Q9P2R7,P50213 386 1.54e-06 107 5 4 0.800 0.037 KEGG:01200 keg 1 Carbon metabolism 1 P51553,O43837,Q9P2R7,P50213 386 4.53e-06 4 5 2 0.400 0.500 GO:0004448 MF 1 isocitrate dehydrogenase activity 1 P51553,O43837 386 4.53e-06 4 5 2 0.400 0.500 GO:0006102 BP 1 isocitrate metabolic process 1 P51553,O43837 386 5.94e-06 257 5 4 0.800 0.016 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P51553,O43837,Q9P2R7,P50213 386 1.91e-05 344 5 4 0.800 0.012 GO:0005759 CC 1 mitochondrial matrix 1 P51553,O43837,Q9P2R7,P50213 386 2.69e-05 375 5 4 0.800 0.011 GO:0055114 BP 1 oxidation-reduction process 1 P51553,O43837,Q9P2R7,P50213 386 3.93e-05 69 5 3 0.600 0.043 KEGG:01230 keg 1 Biosynthesis of amino acids 1 P51553,O43837,P50213 386 2.40e-04 650 5 4 0.800 0.006 GO:0019752 BP 1 carboxylic acid metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 2.77e-04 674 5 4 0.800 0.006 GO:0044429 CC 1 mitochondrial part 1 P51553,O43837,Q9P2R7,P50213 386 3.77e-04 729 5 4 0.800 0.005 GO:0043436 BP 1 oxoacid metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 3.98e-04 739 5 4 0.800 0.005 GO:0006082 BP 1 organic acid metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 9.19e-04 408 5 4 0.800 0.010 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 1.47e-03 1029 5 4 0.800 0.004 GO:0005739 CC 1 mitochondrion 1 P51553,O43837,Q9P2R7,P50213 386 2.18e-03 1 5 1 0.200 1.000 GO:0006781 BP 1 succinyl-CoA pathway 1 Q9P2R7 386 2.98e-03 90 5 2 0.400 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P51553,O43837 386 3.53e-03 98 5 2 0.400 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P51553,O43837 386 4.05e-03 1333 5 4 0.800 0.003 GO:0044281 BP 1 small molecule metabolic process 1 P51553,O43837,Q9P2R7,P50213 386 4.35e-03 2 5 1 0.200 0.500 GO:0004775 MF 1 succinate-CoA ligase (ADP-forming) activity 1 Q9P2R7 386 4.35e-03 2 5 1 0.200 0.500 GO:0046502 BP 1 uroporphyrinogen III metabolic process 1 Q9P2R7 386 4.35e-03 2 5 1 0.200 0.500 GO:0006780 BP 1 uroporphyrinogen III biosynthetic process 1 Q9P2R7 386 4.58e-03 1 5 1 0.200 1.000 OMIM:612073 omi 1 MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH ORWITHOUT METHYLMALONIC ACIDURIA); MTDPS5;;MITOCHONDRIAL DNA DEPLETION SYNDROME, ENCEPHALOMYOPATHIC FORM, WITHOR WITHOUT METHYLMALONIC ACIDURIA, AUTOSOMAL RECESSIVE, SUCLA2-RELATED 1 Q9P2R7 386 4.58e-03 1 5 1 0.200 1.000 OMIM:612572 omi 1 RETINITIS PIGMENTOSA 46; RP46;;RETINITIS PIGMENTOSA, AUTOSOMAL RECESSIVE, IDH3B-RELATED 1 O43837 386 4.87e-03 2 5 1 0.200 0.500 HP:0008945 hp 1 Loss of ability to walk in early childhood 1 Q9P2R7 386 5.95e-03 653 5 4 0.800 0.006 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 6.53e-03 3 5 1 0.200 0.333 GO:0004774 MF 1 succinate-CoA ligase activity 1 Q9P2R7 386 7.29e-03 3 5 1 0.200 0.333 HP:0006915 hp 1 Inability to walk by childhood/adolescence 1 Q9P2R7 386 8.21e-03 331 5 2 0.400 0.006 MI:hsa-miR-661 mi 1 MI:hsa-miR-661 1 P51553,O43837 386 8.43e-03 713 5 4 0.800 0.006 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 8.70e-03 341 5 2 0.400 0.006 MI:hsa-miR-645 mi 1 MI:hsa-miR-645 1 P51553,O43837 386 8.70e-03 4 5 1 0.200 0.250 GO:0006104 BP 1 succinyl-CoA metabolic process 1 Q9P2R7 386 1.13e-02 391 5 2 0.400 0.005 MI:hsa-miR-758 mi 1 MI:hsa-miR-758 1 P51553,P50213 386 1.17e-02 775 5 4 0.800 0.005 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 1.26e-02 1048 5 4 0.800 0.004 KEGG:01100 keg 1 Metabolic pathways 1 P51553,O43837,Q9P2R7,P50213 386 1.30e-02 6 5 1 0.200 0.167 GO:0016405 MF 1 CoA-ligase activity 1 Q9P2R7 386 1.31e-02 421 5 2 0.400 0.005 MI:hsa-miR-30c-1* mi 1 MI:hsa-miR-30c-1* 1 P51553,Q9P2R7 386 1.40e-02 436 5 2 0.400 0.005 MI:hsa-miR-122 mi 1 MI:hsa-miR-122 1 P51553,Q9P2R7 386 1.62e-02 470 5 2 0.400 0.004 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 O43837,Q9P2R7 386 1.66e-02 477 5 2 0.400 0.004 MI:hsa-miR-549 mi 1 MI:hsa-miR-549 1 O43837,P50213 386 1.67e-02 478 5 2 0.400 0.004 MI:mmu-miR-547 mi 1 MI:mmu-miR-547 1 O43837,Q9P2R7 386 1.69e-02 1718 5 4 0.800 0.002 REAC:1430728 rea 1 Metabolism 1 P51553,O43837,Q9P2R7,P50213 386 1.76e-02 491 5 2 0.400 0.004 MI:mmu-miR-540-3p mi 1 MI:mmu-miR-540-3p 1 P51553,O43837 386 1.77e-02 493 5 2 0.400 0.004 MI:hsa-miR-574-5p mi 1 MI:hsa-miR-574-5p 1 P51553,O43837 386 1.88e-02 509 5 2 0.400 0.004 MI:hsa-miR-885-3p mi 1 MI:hsa-miR-885-3p 1 P51553,O43837 386 1.94e-02 8 5 1 0.200 0.125 HP:0002912 hp 1 Methylmalonic acidemia 1 Q9P2R7 386 2.04e-02 531 5 2 0.400 0.004 MI:hsa-miR-132 mi 1 MI:hsa-miR-132 1 O43837,Q9P2R7 386 2.18e-02 9 5 1 0.200 0.111 HP:0002448 hp 1 Progressive encephalopathy 1 Q9P2R7 386 2.20e-02 909 5 4 0.800 0.004 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 P51553,O43837,Q9P2R7,P50213 386 2.39e-02 11 5 1 0.200 0.091 GO:0016878 MF 1 acid-thiol ligase activity 1 Q9P2R7 386 2.48e-02 938 5 4 0.800 0.004 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 2.66e-02 11 5 1 0.200 0.091 HP:0001349 hp 1 Facial diplegia 1 Q9P2R7 386 2.90e-02 12 5 1 0.200 0.083 HP:0004341 hp 1 Abnormality of vitamin B12 metabolism 1 Q9P2R7 386 2.90e-02 12 5 1 0.200 0.083 HP:0012120 hp 1 Methylmalonic aciduria 1 Q9P2R7 386 3.14e-02 13 5 1 0.200 0.077 HP:0004340 hp 1 Abnormality of vitamin B metabolism 1 Q9P2R7 386 3.47e-02 16 5 1 0.200 0.062 GO:0006779 BP 1 porphyrin-containing compound biosynthetic process 1 Q9P2R7 386 3.61e-02 15 5 1 0.200 0.067 HP:0008972 hp 1 Decreased activity of mitochondrial respiratory chain 1 Q9P2R7 386 3.69e-02 17 5 1 0.200 0.059 GO:0033014 BP 1 tetrapyrrole biosynthetic process 1 Q9P2R7 386 3.73e-02 324 5 2 0.400 0.006 GO:0005975 BP 1 carbohydrate metabolic process 1 P51553,P50213 386 3.85e-02 16 5 1 0.200 0.062 HP:0011922 hp 1 Abnormal activity of mitochondrial respiratory chain 1 Q9P2R7 386 4.29e-02 1078 5 4 0.800 0.004 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 4.77e-02 22 5 1 0.200 0.045 GO:0006778 BP 1 porphyrin-containing compound metabolic process 1 Q9P2R7 386 4.79e-02 174 5 2 0.400 0.011 HP:0000512 hp 1 Abnormal electroretinogram 1 O43837,Q9P2R7 386 5.00e-02 2 5 1 0.200 0.500 CORUM:394 cor 1 Succinyl-CoA synthetase, ADP-forming 1 Q9P2R7 386 5.00e-02 69 5 2 0.400 0.029 TF:M07253_1 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 1 1 Q9P2R7,P50213 386 5.00e-02 69 5 2 0.400 0.029 TF:M01132_1 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 1 1 Q9P2R7,P50213 386 5.00e-02 31 5 1 0.200 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 Q9P2R7 386 5.00e-02 56 5 1 0.200 0.018 REAC:1268020 rea 1 Mitochondrial protein import 1 P51553 386 5.00e-02 1121 5 4 0.800 0.004 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P51553,O43837,Q9P2R7,P50213 386 5.00e-02 178 5 2 0.400 0.011 HP:0000597 hp 1 Ophthalmoparesis 1 O43837,Q9P2R7 386 5.00e-02 11 5 1 0.200 0.091 OMIM:603041 omi 1 Autosomal Recessive Mitochondrial DNA Depletion Syndromes 1 Q9P2R7 387 2.78e-05 32 2 2 1.000 0.062 GO:0032040 CC 1 small-subunit processome 1 O75691,Q9NV06 387 3.34e-05 35 2 2 1.000 0.057 GO:0000462 BP 1 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691,Q9NV06 387 5.80e-05 46 2 2 1.000 0.043 GO:0030490 BP 1 maturation of SSU-rRNA 1 O75691,Q9NV06 387 1.03e-04 61 2 2 1.000 0.033 GO:0042274 BP 1 ribosomal small subunit biogenesis 1 O75691,Q9NV06 387 1.32e-04 69 2 2 1.000 0.029 GO:0030684 CC 1 preribosome 1 O75691,Q9NV06 387 9.03e-04 200 2 2 1.000 0.010 REAC:72312 rea 1 rRNA processing 1 O75691,Q9NV06 387 1.44e-03 425 2 2 1.000 0.005 MI:mmu-miR-344 mi 1 MI:mmu-miR-344 1 O75691,Q9NV06 387 1.46e-03 229 2 2 1.000 0.009 GO:0006364 BP 1 rRNA processing 1 O75691,Q9NV06 387 1.50e-03 232 2 2 1.000 0.009 GO:0016072 BP 1 rRNA metabolic process 1 O75691,Q9NV06 387 1.94e-03 3 2 1 0.500 0.333 GO:0000472 BP 1 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691 387 1.94e-03 3 2 1 0.500 0.333 GO:0000967 BP 1 rRNA 5'-end processing 1 O75691 387 1.94e-03 3 2 1 0.500 0.333 GO:0034471 BP 1 ncRNA 5'-end processing 1 O75691 387 2.16e-03 278 2 2 1.000 0.007 GO:0042254 BP 1 ribosome biogenesis 1 O75691,Q9NV06 387 2.59e-03 4 2 1 0.500 0.250 GO:0000480 BP 1 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691 387 2.65e-03 8 2 1 0.500 0.125 TF:M06542_0 tf 1 Factor: ZNF502; motif: NTGWTGATAATC; match class: 0 1 Q9NV06 387 3.39e-03 348 2 2 1.000 0.006 GO:0034470 BP 1 ncRNA processing 1 O75691,Q9NV06 387 3.88e-03 6 2 1 0.500 0.167 GO:0000447 BP 1 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691 387 3.88e-03 6 2 1 0.500 0.167 GO:0030688 CC 1 preribosome, small subunit precursor 1 O75691 387 3.88e-03 6 2 1 0.500 0.167 GO:0000966 BP 1 RNA 5'-end processing 1 O75691 387 4.34e-03 394 2 2 1.000 0.005 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 O75691,Q9NV06 387 6.46e-03 10 2 1 0.500 0.100 GO:0000479 BP 1 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691 387 6.77e-03 492 2 2 1.000 0.004 GO:0034660 BP 1 ncRNA metabolic process 1 O75691,Q9NV06 387 7.11e-03 11 2 1 0.500 0.091 GO:0000478 BP 1 endonucleolytic cleavage involved in rRNA processing 1 O75691 387 7.36e-03 753 2 2 1.000 0.003 TF:M00796_1 tf 1 Factor: USF; motif: NRCCACGTGASN; match class: 1 1 O75691,Q9NV06 387 8.06e-03 788 2 2 1.000 0.003 TF:M07233_0 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 0 1 O75691,Q9NV06 387 9.26e-03 28 2 1 0.500 0.036 TF:M06120_0 tf 1 Factor: ZNF43; motif: NGTGGCGGAATA; match class: 0 1 Q9NV06 387 1.00e-02 599 2 2 1.000 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 O75691,Q9NV06 387 1.01e-02 600 2 2 1.000 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 O75691,Q9NV06 387 1.03e-02 16 2 1 0.500 0.062 GO:0090502 BP 1 RNA phosphodiester bond hydrolysis, endonucleolytic 1 O75691 387 1.16e-02 18 2 1 0.500 0.056 GO:0000466 BP 1 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 O75691 387 1.16e-02 645 2 2 1.000 0.003 GO:0005730 CC 1 nucleolus 1 O75691,Q9NV06 387 1.36e-02 21 2 1 0.500 0.048 GO:0000469 BP 1 cleavage involved in rRNA processing 1 O75691 387 1.55e-02 47 2 1 0.500 0.021 TF:M05846_0 tf 1 Factor: ZNF689; motif: NRGGTTAAGTGC; match class: 0 1 Q9NV06 387 1.58e-02 752 2 2 1.000 0.003 GO:0006396 BP 1 RNA processing 1 O75691,Q9NV06 387 1.62e-02 25 2 1 0.500 0.040 GO:0080008 CC 1 Cul4-RING E3 ubiquitin ligase complex 1 Q9NV06 387 1.62e-02 49 2 1 0.500 0.020 TF:M03995_0 tf 1 Factor: SPIB; motif: NAAAAGMGGAAGTN; match class: 0 1 Q9NV06 387 1.68e-02 26 2 1 0.500 0.038 GO:0030686 CC 1 90S preribosome 1 O75691 387 1.72e-02 52 2 1 0.500 0.019 TF:M05601_0 tf 1 Factor: FIZ1; motif: GGGSTMGGCCT; match class: 0 1 Q9NV06 387 1.75e-02 53 2 1 0.500 0.019 TF:M05879_0 tf 1 Factor: ZNF713; motif: GTTGATAATC; match class: 0 1 Q9NV06 387 1.94e-02 30 2 1 0.500 0.033 GO:0000460 BP 1 maturation of 5.8S rRNA 1 O75691 387 2.41e-02 73 2 1 0.500 0.014 TF:M03996_1 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 1 1 Q9NV06 387 2.74e-02 1453 2 2 1.000 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 O75691,Q9NV06 387 2.92e-02 1500 2 2 1.000 0.001 TF:M01108_1 tf 1 Factor: HOXA7; motif: YCAATCT; match class: 1 1 O75691,Q9NV06 387 3.03e-02 92 2 1 0.500 0.011 TF:M06359_0 tf 1 Factor: ZNF562; motif: TAGGGGGAGGA; match class: 0 1 Q9NV06 387 3.03e-02 92 2 1 0.500 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 O75691 387 3.10e-02 48 2 1 0.500 0.021 GO:0090501 BP 1 RNA phosphodiester bond hydrolysis 1 O75691 387 3.16e-02 96 2 1 0.500 0.010 TF:M04204_0 tf 1 Factor: CEBPG; motif: ATTRCGCAAY; match class: 0 1 O75691 387 3.23e-02 98 2 1 0.500 0.010 TF:M07233_1 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 1 1 Q9NV06 387 3.50e-02 1118 2 2 1.000 0.002 GO:0044822 MF 1 poly(A) RNA binding 1 O75691,Q9NV06 387 3.69e-02 112 2 1 0.500 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 Q9NV06 387 3.92e-02 1737 2 2 1.000 0.001 TF:M00350_1 tf 1 Factor: GATA-3; motif: NGAGATAANA; match class: 1 1 O75691,Q9NV06 387 4.04e-02 1764 2 2 1.000 0.001 TF:M04194_0 tf 1 Factor: TFEB; motif: RNCACGTGAC; match class: 0 1 O75691,Q9NV06 387 4.10e-02 1776 2 2 1.000 0.001 TF:M01843_1 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 1 1 O75691,Q9NV06 387 4.62e-02 1886 2 2 1.000 0.001 TF:M00217_1 tf 1 Factor: USF; motif: NCACGTGN; match class: 1 1 O75691,Q9NV06 387 4.71e-02 143 2 1 0.500 0.007 TF:M04202_0 tf 1 Factor: CEBPD; motif: RTTRCGCAAY; match class: 0 1 O75691 387 5.00e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q9NV06 387 5.00e-02 1485 2 2 1.000 0.001 REAC:74160 rea 1 Gene Expression 1 O75691,Q9NV06 387 5.00e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q9NV06 387 5.00e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q9NV06 387 5.00e-02 1336 2 2 1.000 0.001 GO:0003723 MF 1 RNA binding 1 O75691,Q9NV06 387 5.00e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q9NV06 389 2.97e-19 11 12 7 0.583 0.636 GO:0042555 CC 1 MCM complex 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 6.28e-15 6 12 6 0.500 1.000 CORUM:387 cor 1 MCM complex 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 6.92e-15 12 12 6 0.500 0.500 REAC:176974 rea 1 Unwinding of DNA 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 5.44e-12 31 12 6 0.500 0.194 REAC:68962 rea 1 Activation of the pre-replicative complex 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 6.69e-12 32 12 6 0.500 0.188 REAC:69190 rea 1 DNA strand elongation 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.43e-11 36 12 6 0.500 0.167 REAC:176187 rea 1 Activation of ATR in response to replication stress 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 5.91e-10 4 12 4 0.333 1.000 CORUM:2792 cor 1 MCM2-MCM4-MCM6-MCM7 complex 1 P49736,Q14566,P33991,P33993 389 7.19e-10 67 12 6 0.500 0.090 REAC:68867 rea 1 Assembly of the pre-replicative complex 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 9.42e-10 70 12 6 0.500 0.086 REAC:68949 rea 1 Orc1 removal from chromatin 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 9.42e-10 70 12 6 0.500 0.086 REAC:69052 rea 1 Switching of origins to a post-replicative state 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.12e-09 72 12 6 0.500 0.083 REAC:69300 rea 1 Removal of licensing factors from origins 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.44e-09 75 12 6 0.500 0.080 REAC:69304 rea 1 Regulation of DNA replication 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.98e-09 100 12 6 0.500 0.060 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 2.69e-09 83 12 6 0.500 0.072 REAC:68874 rea 1 M/G1 Transition 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 2.69e-09 83 12 6 0.500 0.072 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 3.39e-09 217 12 7 0.583 0.032 GO:0006260 BP 1 DNA replication 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 3.96e-09 112 12 6 0.500 0.054 GO:0000781 CC 1 chromosome, telomeric region 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 7.89e-09 99 12 6 0.500 0.061 REAC:69239 rea 1 Synthesis of DNA 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.19e-08 106 12 6 0.500 0.057 REAC:69306 rea 1 DNA Replication 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.96e-08 115 12 6 0.500 0.052 REAC:69206 rea 1 G1/S Transition 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 3.40e-08 126 12 6 0.500 0.048 REAC:69242 rea 1 S Phase 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 5.88e-08 138 12 6 0.500 0.043 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 6.51e-08 178 12 6 0.500 0.034 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 7.28e-08 143 12 6 0.500 0.042 REAC:69481 rea 1 G2/M Checkpoints 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 8.21e-08 185 12 6 0.500 0.032 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.09e-07 357 12 7 0.583 0.020 GO:0044454 CC 1 nuclear chromosome part 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 1.51e-07 3 12 3 0.250 1.000 CORUM:1452 cor 1 MCM2-MCM6-MCM7 complex 1 P49736,Q14566,P33993 389 1.51e-07 3 12 3 0.250 1.000 CORUM:2791 cor 1 MCM4-MCM6-MCM7 complex 1 Q14566,P33991,P33993 389 1.77e-07 383 12 7 0.583 0.018 GO:0000228 CC 1 nuclear chromosome 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 2.21e-07 631 12 8 0.667 0.013 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.36e-07 174 12 6 0.500 0.034 REAC:69620 rea 1 Cell Cycle Checkpoints 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 3.02e-07 230 12 6 0.500 0.026 GO:0098687 CC 1 chromosomal region 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 3.06e-07 670 12 8 0.667 0.012 GO:0006259 BP 1 DNA metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P26358,P33993,Q9BTE3 389 3.69e-07 25 12 4 0.333 0.160 TF:M00516_1 tf 1 Factor: E2F; motif: TTTSGCGCGMNR; match class: 1 1 P49736,Q14566,P33992,P26358 389 9.85e-07 486 12 7 0.583 0.014 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 P49736,Q14566,P33992,P33991,P26358,Q9Y3E5,P33993 389 2.55e-06 565 12 7 0.583 0.012 GO:0044427 CC 1 chromosomal part 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 3.29e-06 580 12 7 0.583 0.012 HPA:046010_13 hpa 1 tonsil; germinal center cells[Supportive,High] 1 Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 4.25e-06 609 12 7 0.583 0.011 GO:0005694 CC 1 chromosome 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 5.96e-06 1703 12 10 0.833 0.006 TF:M00940_0 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 0 1 Q9P219,P49736,Q14566,P33992,P25205,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 5.97e-06 965 12 8 0.667 0.008 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.36e-06 973 12 8 0.667 0.008 HPA:023010_03 hpa 1 lymph node; germinal center cells[Uncertain,High] 1 Q9P219,P49736,Q14566,P33992,P33991,P26358,Q9Y3E5,P33993 389 6.83e-06 1408 12 9 0.750 0.006 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.31e-06 411 12 6 0.500 0.015 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.04e-05 309 12 6 0.500 0.019 TF:M00919_1 tf 1 Factor: E2F; motif: NCSCGCSAAAN; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.13e-05 425 12 6 0.500 0.014 GO:0044770 BP 1 cell cycle phase transition 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.16e-05 315 12 6 0.500 0.019 TF:M00740_1 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.56e-05 1550 12 9 0.750 0.006 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 Q9P219,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.70e-05 28 12 3 0.250 0.107 GO:0004003 MF 1 ATP-dependent DNA helicase activity 1 Q14566,P33991,P33993 389 1.93e-05 1589 12 9 0.750 0.006 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.05e-05 1600 12 9 0.750 0.006 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.28e-05 353 12 6 0.500 0.017 TF:M00920_1 tf 1 Factor: E2F; motif: NKCGCGCSAAAN; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 2.77e-05 365 12 6 0.500 0.016 TF:M00939_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 3.24e-05 189 12 5 0.417 0.026 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358 389 3.38e-05 36 12 6 0.500 0.167 KEGG:03030 keg 1 DNA replication 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 4.19e-05 13 12 3 0.250 0.231 CORUM:5611 cor 1 Emerin complex 24 1 P49736,Q14566,P33991 389 4.97e-05 206 12 5 0.417 0.024 TF:M00736_1 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P33993 389 5.92e-05 448 12 6 0.500 0.013 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 8.11e-05 1360 12 8 0.667 0.006 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 8.33e-05 47 12 3 0.250 0.064 GO:0003678 MF 1 DNA helicase activity 1 Q14566,P33991,P33993 389 8.56e-05 952 12 7 0.583 0.007 GO:0022402 BP 1 cell cycle process 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 1.15e-04 634 12 6 0.500 0.009 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P49736,Q14566,P33991,P53999,Q9Y3E5,P33993 389 1.29e-04 1986 12 9 0.750 0.005 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.35e-04 1998 12 9 0.750 0.005 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.41e-04 657 12 6 0.500 0.009 GO:1903047 BP 1 mitotic cell cycle process 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 1.61e-04 493 12 6 0.500 0.012 TF:M00737_1 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.83e-04 547 12 6 0.500 0.011 REAC:1640170 rea 1 Cell Cycle 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 2.07e-04 2102 12 9 0.750 0.004 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.18e-04 278 12 5 0.417 0.018 TF:M00918_1 tf 1 Factor: E2F; motif: TTTSGCGSG; match class: 1 1 P49736,Q14566,P33992,P26358,P33993 389 2.31e-04 2130 12 9 0.750 0.004 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.39e-04 721 12 6 0.500 0.008 GO:0000278 BP 1 mitotic cell cycle 1 P49736,Q14566,P33992,P33991,P25205,P33993 389 2.51e-04 866 12 7 0.583 0.008 TF:M00024_0 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 0 1 P49736,P33992,P33991,P25205,P26358,Q5T0N5,Q9Y3E5 389 2.51e-04 2151 12 9 0.750 0.004 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.62e-04 1128 12 7 0.583 0.006 GO:0007049 BP 1 cell cycle 1 P49736,Q14566,P33992,P33991,P25205,P33993,Q9BTE3 389 2.77e-04 2176 12 9 0.750 0.004 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.90e-04 71 12 3 0.250 0.042 GO:0008094 MF 1 DNA-dependent ATPase activity 1 Q14566,P33991,P33993 389 2.93e-04 2191 12 9 0.750 0.004 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.96e-04 296 12 5 0.417 0.017 TF:M00516_0 tf 1 Factor: E2F; motif: TTTSGCGCGMNR; match class: 0 1 P49736,Q14566,P33992,P26358,P33993 389 3.00e-04 2197 12 9 0.750 0.004 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 3.21e-04 2215 12 9 0.750 0.004 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 3.68e-04 1920 12 9 0.750 0.005 TF:M00736_0 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 0 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 3.94e-04 2270 12 9 0.750 0.004 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 3.95e-04 2271 12 9 0.750 0.004 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 4.55e-04 2310 12 9 0.750 0.004 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 4.62e-04 1220 12 7 0.583 0.006 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 5.16e-04 3591 12 11 0.917 0.003 TF:M00425_0 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 0 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993 389 5.19e-04 3593 12 11 0.917 0.003 TF:M00431_0 tf 1 Factor: E2F-1; motif: TTTSGCGS; match class: 0 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993 389 5.51e-04 88 12 3 0.250 0.034 GO:0070035 MF 1 purine NTP-dependent helicase activity 1 Q14566,P33991,P33993 389 5.51e-04 88 12 3 0.250 0.034 GO:0008026 MF 1 ATP-dependent helicase activity 1 Q14566,P33991,P33993 389 5.55e-04 2366 12 9 0.750 0.004 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.18e-04 46 12 3 0.250 0.065 TF:M00024_1 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 1 1 P49736,P33991,P26358 389 6.18e-04 2397 12 9 0.750 0.004 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.98e-04 159 12 4 0.333 0.025 TF:M00940_1 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 1 P49736,Q14566,P25205,P26358 389 7.51e-04 2454 12 9 0.750 0.004 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.11e-04 2477 12 9 0.750 0.004 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.61e-04 2495 12 9 0.750 0.004 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.89e-04 2505 12 9 0.750 0.004 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.39e-04 564 12 5 0.417 0.009 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q14566,P33991,P53999,Q9Y3E5,P33993 389 1.09e-03 1960 12 8 0.667 0.004 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P49736,Q14566,P33992,P33991,P25205,P53999,P33993,Q9BTE3 389 1.09e-03 1960 12 8 0.667 0.004 GO:0043228 CC 1 non-membrane-bounded organelle 1 P49736,Q14566,P33992,P33991,P25205,P53999,P33993,Q9BTE3 389 1.13e-03 112 12 3 0.250 0.027 GO:0004386 MF 1 helicase activity 1 Q14566,P33991,P33993 389 1.15e-03 2941 12 10 0.833 0.003 TF:M00737_0 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 0 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,P33993,Q9BTE3 389 1.15e-03 2585 12 9 0.750 0.003 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 Q9P219,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.27e-03 1974 12 8 0.667 0.004 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 1.35e-03 119 12 3 0.250 0.025 GO:0006261 BP 1 DNA-dependent DNA replication 1 P49736,P25205,Q9BTE3 389 1.38e-03 1996 12 8 0.667 0.004 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 1.46e-03 722 12 6 0.500 0.008 TF:M00050_1 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.63e-03 5612 12 12 1.000 0.002 HPA:023010_01 hpa 1 lymph node; germinal center cells[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 1.72e-03 2770 12 9 0.750 0.003 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.77e-03 2096 12 8 0.667 0.004 GO:0043234 CC 1 protein complex 1 P49736,Q14566,P33992,P33991,P25205,P53999,P33993,Q9BTE3 389 1.79e-03 1508 12 7 0.583 0.005 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 Q9P219,P49736,Q14566,P33991,P53999,Q9Y3E5,P33993 389 1.82e-03 650 12 5 0.417 0.008 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q14566,P33991,P53999,Q9Y3E5,P33993 389 1.83e-03 751 12 6 0.500 0.008 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.86e-03 3521 12 10 0.833 0.003 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.90e-03 756 12 6 0.500 0.008 TF:M00425_1 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 1.99e-03 438 12 5 0.417 0.011 TF:M00427_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 P49736,Q14566,P33992,P26358,P33993 389 2.29e-03 2869 12 9 0.750 0.003 GO:0009059 BP 1 macromolecule biosynthetic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 2.34e-03 784 12 6 0.500 0.008 TF:M00426_1 tf 1 Factor: E2F; motif: TTTSGCGS; match class: 1 1 P49736,Q14566,P33992,P25205,P26358,P33993 389 2.50e-03 2168 12 8 0.667 0.004 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 2.60e-03 30 12 2 0.167 0.067 GO:0006270 BP 1 DNA replication initiation 1 P49736,P25205 389 2.72e-03 2931 12 9 0.750 0.003 GO:0031981 CC 1 nuclear lumen 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 2.86e-03 2209 12 8 0.667 0.004 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 3.32e-03 2489 12 9 0.750 0.004 TF:M07380_0 tf 1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 0 1 Q9P219,Q14566,P33992,P33991,P25205,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 3.40e-03 3013 12 9 0.750 0.003 GO:0090304 BP 1 nucleic acid metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 3.52e-03 2274 12 8 0.667 0.004 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 4.34e-03 3045 12 9 0.750 0.003 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 4.49e-03 1339 12 7 0.583 0.005 TF:M03925_1 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 1 Q9P219,P49736,P33992,P33991,P26358,P33993,Q9BTE3 389 4.69e-03 1 12 1 0.083 1.000 OMIM:616263 omi 1 NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET;IMNEPD 1 Q9Y3E5 389 4.69e-03 1 12 1 0.083 1.000 OMIM:223100 omi 1 LACTOSE INTOLERANCE, ADULT TYPE;;HYPOLACTASIA, ADULT TYPE;;ADULT LACTASE DEFICIENCY;;DISACCHARIDE INTOLERANCE IIILACTASE PERSISTENCE, INCLUDED 1 Q14566 389 4.69e-03 1 12 1 0.083 1.000 OMIM:604121 omi 1 CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT; ADCADN 1 P26358 389 4.69e-03 1 12 1 0.083 1.000 OMIM:614116 omi 1 NEUROPATHY, HEREDITARY SENSORY, TYPE IE; HSN1E;;HSN IE;;NEUROPATHY, HEREDITARY SENSORY, WITH HEARING LOSS AND DEMENTIA 1 P26358 389 4.69e-03 1 12 1 0.083 1.000 OMIM:616053 omi 1 SPINOCEREBELLAR ATAXIA 40; SCA40 1 Q9P219 389 4.69e-03 1 12 1 0.083 1.000 OMIM:609981 omi 1 NATURAL KILLER CELL AND GLUCOCORTICOID DEFICIENCY WITH DNA REPAIRDEFECT; NKGCD;;NATURAL KILLER CELL DEFICIENCY, FAMILIAL ISOLATED; NKCD 1 P33991 389 5.10e-03 1782 12 7 0.583 0.004 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P49736,Q14566,P33992,P33991,P53999,Q9Y3E5,P33993 389 5.10e-03 3168 12 9 0.750 0.003 GO:0044428 CC 1 nuclear part 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 5.12e-03 1256 12 6 0.500 0.005 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 Q9P219,Q14566,P33991,P53999,Q9Y3E5,P33993 389 5.41e-03 2417 12 8 0.667 0.003 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 5.70e-03 2435 12 8 0.667 0.003 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 6.09e-03 2458 12 8 0.667 0.003 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P49736,Q14566,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.28e-03 2469 12 8 0.667 0.003 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P49736,Q14566,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.57e-03 3208 12 9 0.750 0.003 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.78e-03 2496 12 8 0.667 0.003 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P49736,Q14566,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 6.79e-03 2529 12 8 0.667 0.003 GO:0005654 CC 1 nucleoplasm 1 P49736,Q14566,P33992,P33991,P25205,P26358,P33993,Q9BTE3 389 7.05e-03 3566 12 10 0.833 0.003 TF:M00050_0 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 0 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,P33993,Q9BTE3 389 7.23e-03 3247 12 9 0.750 0.003 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 7.25e-03 1 12 1 0.083 1.000 CORUM:1028 cor 1 HNF4A-SUB1 complex 1 P53999 389 7.58e-03 6377 12 12 1.000 0.002 HPA:021010 hpa 1 liver; bile duct cells 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 8.40e-03 2574 12 8 0.667 0.003 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P26358,Q9Y3E5,P33993 389 8.47e-03 5319 12 11 0.917 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993,Q9BTE3 389 8.75e-03 3326 12 9 0.750 0.003 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.75e-03 3326 12 9 0.750 0.003 HPA:008010_10 hpa 1 cervix, uterine; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.91e-03 3334 12 9 0.750 0.003 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 8.91e-03 2 12 1 0.083 0.500 HP:0004789 hp 1 Lactose intolerance 1 Q14566 389 9.00e-03 6469 12 12 1.000 0.002 HPA:046010_01 hpa 1 tonsil; germinal center cells[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 9.12e-03 3344 12 9 0.750 0.003 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.12e-03 3344 12 9 0.750 0.003 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.15e-03 3667 12 10 0.833 0.003 TF:M00739_0 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 0 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,P33993,Q9BTE3 389 9.36e-03 3355 12 9 0.750 0.003 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.65e-03 3368 12 9 0.750 0.003 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.70e-03 3370 12 9 0.750 0.003 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.71e-03 4225 12 10 0.833 0.002 HPA:046010_02 hpa 1 tonsil; germinal center cells[Uncertain,Medium] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.73e-03 922 12 5 0.417 0.005 GO:0003677 MF 1 DNA binding 1 P49736,P25205,P53999,P26358,P33993 389 9.76e-03 6513 12 12 1.000 0.002 HPA:046020_01 hpa 1 tonsil; non-germinal center cells[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 9.90e-03 3379 12 9 0.750 0.003 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 9.91e-03 3443 12 9 0.750 0.003 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.01e-02 3386 12 9 0.750 0.003 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.01e-02 3386 12 9 0.750 0.003 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.01e-02 3386 12 9 0.750 0.003 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.02e-02 3390 12 9 0.750 0.003 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.05e-02 3403 12 9 0.750 0.003 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.05e-02 5272 12 11 0.917 0.002 HPA:040040 hpa 1 soft tissue 2; peripheral nerve 1 Q9P219,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 1.05e-02 3405 12 9 0.750 0.003 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.06e-02 3407 12 9 0.750 0.003 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.06e-02 3407 12 9 0.750 0.003 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.06e-02 4 12 1 0.083 0.250 REAC:5368598 rea 1 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1 Q9P219 389 1.07e-02 3412 12 9 0.750 0.003 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.07e-02 3413 12 9 0.750 0.003 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.08e-02 3415 12 9 0.750 0.003 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.08e-02 3416 12 9 0.750 0.003 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.08e-02 3416 12 9 0.750 0.003 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.08e-02 3416 12 9 0.750 0.003 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.08e-02 3418 12 9 0.750 0.003 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.09e-02 3420 12 9 0.750 0.003 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.09e-02 3421 12 9 0.750 0.003 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.09e-02 3422 12 9 0.750 0.003 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.09e-02 3422 12 9 0.750 0.003 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.10e-02 3423 12 9 0.750 0.003 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.10e-02 3423 12 9 0.750 0.003 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.10e-02 564 12 4 0.333 0.007 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q14566,P33991,P53999,Q9Y3E5 389 1.10e-02 3424 12 9 0.750 0.003 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.10e-02 3426 12 9 0.750 0.003 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.10e-02 3426 12 9 0.750 0.003 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.11e-02 3428 12 9 0.750 0.003 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.11e-02 3429 12 9 0.750 0.003 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.11e-02 3429 12 9 0.750 0.003 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.11e-02 3429 12 9 0.750 0.003 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.11e-02 3430 12 9 0.750 0.003 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3431 12 9 0.750 0.003 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3432 12 9 0.750 0.003 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3433 12 9 0.750 0.003 HPA:007030_10 hpa 1 cerebral cortex; neuronal cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3433 12 9 0.750 0.003 HPA:018020_10 hpa 1 hippocampus; neuronal cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3433 12 9 0.750 0.003 HPA:032010_10 hpa 1 salivary gland; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:037010_10 hpa 1 small intestine; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:022010_10 hpa 1 lung; macrophages[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:021020_10 hpa 1 liver; hepatocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:038010_10 hpa 1 smooth muscle; smooth muscle cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:044010_10 hpa 1 testis; Leydig cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:007020_10 hpa 1 cerebral cortex; glial cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:011020_10 hpa 1 endometrium 1; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.12e-02 3434 12 9 0.750 0.003 HPA:030010_10 hpa 1 prostate; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3499 12 9 0.750 0.003 GO:0044249 BP 1 cellular biosynthetic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.13e-02 3435 12 9 0.750 0.003 HPA:027010_10 hpa 1 pancreas; exocrine glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:015010_10 hpa 1 fallopian tube; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:010010_10 hpa 1 duodenum; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:045010_10 hpa 1 thyroid gland; glandular cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:022020_10 hpa 1 lung; pneumocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:017010_10 hpa 1 heart muscle; myocytes[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:044020_10 hpa 1 testis; cells in seminiferous ducts[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:019020_10 hpa 1 kidney; cells in tubules[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:041010_10 hpa 1 spleen; cells in red pulp[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.13e-02 3435 12 9 0.750 0.003 HPA:029020_10 hpa 1 placenta; trophoblastic cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.27e-02 3554 12 9 0.750 0.003 GO:0046483 BP 1 heterocycle metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.28e-02 2072 12 7 0.583 0.003 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q14566,P33992,P33991,P25205,P53999,Q9Y3E5,P33993 389 1.29e-02 3561 12 9 0.750 0.003 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.29e-02 3561 12 9 0.750 0.003 GO:0070013 CC 1 intracellular organelle lumen 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.29e-02 3561 12 9 0.750 0.003 GO:0031974 CC 1 membrane-enclosed lumen 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.29e-02 3561 12 9 0.750 0.003 GO:0043233 CC 1 organelle lumen 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.32e-02 3569 12 9 0.750 0.003 GO:1901576 BP 1 organic substance biosynthetic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.33e-02 3 12 1 0.083 0.333 HP:0006879 hp 1 Pontocerebellar atrophy 1 Q9P219 389 1.37e-02 264 12 3 0.250 0.011 GO:0042623 MF 1 ATPase activity, coupled 1 Q14566,P33991,P33993 389 1.40e-02 3 12 1 0.083 0.333 OMIM:236600 omi 1 Congenital Hydrocephalus 1 Q9P219 389 1.45e-02 2 12 1 0.083 0.500 CORUM:862 cor 1 DNMT1-G9a complex 1 P26358 389 1.47e-02 3620 12 9 0.750 0.002 GO:0009058 BP 1 biosynthetic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.60e-02 1559 12 6 0.500 0.004 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q14566,P33991,P25205,P53999,Q9Y3E5,P33993 389 1.68e-02 3681 12 9 0.750 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 1.75e-02 2183 12 7 0.583 0.003 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P49736,Q14566,P33991,P25205,P53999,Q9Y3E5,P33993 389 1.82e-02 1599 12 6 0.500 0.004 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 Q9P219,Q14566,P33991,P53999,Q9Y3E5,P33993 389 1.83e-02 2200 12 7 0.583 0.003 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P49736,Q14566,P33992,P25205,P53999,P26358,P33993 389 1.86e-02 294 12 3 0.250 0.010 GO:0000785 CC 1 chromatin 1 P49736,P33993,Q9BTE3 389 1.91e-02 3 12 1 0.083 0.333 GO:0003886 MF 1 DNA (cytosine-5-)-methyltransferase activity 1 P26358 389 1.97e-02 2227 12 7 0.583 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P49736,Q14566,P33991,P25205,P53999,Q9Y3E5,P33993 389 1.97e-02 2914 12 8 0.667 0.003 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 1.97e-02 4578 12 10 0.833 0.002 HPA:003010_02 hpa 1 bone marrow; hematopoietic cells[Uncertain,Medium] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q9Y3E5,P33993 389 2.02e-02 1107 12 5 0.417 0.005 HPA:041020_12 hpa 1 spleen; cells in white pulp[Supportive,Medium] 1 Q14566,P33992,P33991,P53999,Q9Y3E5 389 2.14e-02 6952 12 12 1.000 0.002 HPA:023010 hpa 1 lymph node; germinal center cells 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 2.16e-02 3 12 1 0.083 0.333 CORUM:860 cor 1 DNMT1-G9a-PCNA complex 1 P26358 389 2.16e-02 3 12 1 0.083 0.333 CORUM:1491 cor 1 RGS6-DNMT1-DMAP1 complex 1 P26358 389 2.16e-02 3 12 1 0.083 0.333 CORUM:1490 cor 1 DAXX-DNMT1-DMAP1 complex 1 P26358 389 2.20e-02 6969 12 12 1.000 0.002 HPA:035030_01 hpa 1 skin 1; keratinocytes[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 2.20e-02 1659 12 6 0.500 0.004 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P49736,Q14566,P33991,P53999,Q9Y3E5,P33993 389 2.21e-02 5 12 1 0.083 0.200 HP:0030050 hp 1 Narcolepsy 1 P26358 389 2.21e-02 5 12 1 0.083 0.200 HP:0001262 hp 1 Somnolence 1 P26358 389 2.30e-02 2286 12 7 0.583 0.003 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P53999,Q9Y3E5,P33993 389 2.35e-02 2295 12 7 0.583 0.003 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P49736,Q14566,P33991,P25205,P53999,Q9Y3E5,P33993 389 2.55e-02 4 12 1 0.083 0.250 GO:0030050 BP 1 vesicle transport along actin filament 1 Q5T0N5 389 2.55e-02 4 12 1 0.083 0.250 GO:0009008 MF 1 DNA-methyltransferase activity 1 P26358 389 2.55e-02 4 12 1 0.083 0.250 GO:0090309 BP 1 positive regulation of methylation-dependent chromatin silencing 1 P26358 389 2.55e-02 4 12 1 0.083 0.250 GO:0005658 CC 1 alpha DNA polymerase:primase complex 1 P25205 389 2.65e-02 6 12 1 0.083 0.167 HP:0005523 hp 1 Lymphoproliferative disorder 1 P33991 389 2.78e-02 5806 12 11 0.917 0.002 HPA:040010 hpa 1 soft tissue 2; adipocytes 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993 389 2.84e-02 7119 12 12 1.000 0.002 HPA:025010_01 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 2.88e-02 4 12 1 0.083 0.250 CORUM:5695 cor 1 TIP5-DNMT-HDAC1 complex 1 P26358 389 2.88e-02 4 12 1 0.083 0.250 CORUM:1488 cor 1 DNMT1-RB1-HDAC1-E2F1 complex 1 P26358 389 2.89e-02 3948 12 9 0.750 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 3.02e-02 1765 12 6 0.500 0.003 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P53999,Q9Y3E5 389 3.09e-02 7 12 1 0.083 0.143 HP:0002524 hp 1 Cataplexy 1 P26358 389 3.14e-02 354 12 3 0.250 0.008 GO:0016887 MF 1 ATPase activity 1 Q14566,P33991,P33993 389 3.18e-02 5 12 1 0.083 0.200 GO:0051573 BP 1 negative regulation of histone H3-K9 methylation 1 P26358 389 3.18e-02 5 12 1 0.083 0.200 GO:2000210 BP 1 positive regulation of anoikis 1 Q9Y3E5 389 3.18e-02 5 12 1 0.083 0.200 GO:0010216 BP 1 maintenance of DNA methylation 1 P26358 389 3.21e-02 788 12 5 0.417 0.006 TF:M00431_1 tf 1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 1 P49736,Q14566,P33992,P26358,P33993 389 3.27e-02 2429 12 7 0.583 0.003 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P49736,Q14566,P33992,P33991,P53999,Q9Y3E5,P33993 389 3.42e-02 4990 12 10 0.833 0.002 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,P33993,Q9BTE3 389 3.45e-02 1813 12 6 0.500 0.003 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P49736,Q14566,P33991,P53999,Q9Y3E5,P33993 389 3.49e-02 2456 12 7 0.583 0.003 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 3.50e-02 1818 12 6 0.500 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P49736,Q14566,P33991,P53999,Q9Y3E5,P33993 389 3.59e-02 5 12 1 0.083 0.200 CORUM:1470 cor 1 pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) 1 P26358 389 3.59e-02 5 12 1 0.083 0.200 CORUM:5117 cor 1 pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) 1 P26358 389 3.70e-02 7278 12 12 1.000 0.002 HPA:006020 hpa 1 cerebellum; cells in granular layer 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 3.80e-02 7294 12 12 1.000 0.002 HPA:035020 hpa 1 skin 1; fibroblasts 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 3.82e-02 6 12 1 0.083 0.167 GO:0099515 BP 1 actin filament-based transport 1 Q5T0N5 389 3.96e-02 7319 12 12 1.000 0.002 HPA:008020 hpa 1 cervix, uterine; squamous epithelial cells 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 4.17e-02 6046 12 11 0.917 0.002 HPA:008020_01 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Low] 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 4.44e-02 3293 12 8 0.667 0.002 HPA:002020_02 hpa 1 appendix; lymphoid tissue[Uncertain,Medium] 1 P49736,Q14566,P33992,P33991,P53999,P26358,Q9Y3E5,P33993 389 4.45e-02 7 12 1 0.083 0.143 GO:0031937 BP 1 positive regulation of chromatin silencing 1 P26358 389 4.54e-02 838 12 4 0.333 0.005 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 Q14566,P53999,Q9Y3E5,P33993 389 4.65e-02 7682 12 12 1.000 0.002 GO:0005488 MF 1 binding 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 5.00e-02 6336 12 11 0.917 0.002 GO:0005515 MF 1 protein binding 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 5.00e-02 1953 12 7 0.583 0.004 TF:M00428_1 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 1 Q9P219,P49736,Q14566,P33992,P53999,P26358,P33993 389 5.00e-02 7 12 1 0.083 0.143 CORUM:1106 cor 1 TFIIIC containing-TOP1-SUB1 complex 1 P53999 389 5.00e-02 7462 12 12 1.000 0.002 HPA:026000 hpa 1 ovary 1 Q9P219,P49736,Q14566,P33992,P33991,P25205,P53999,P26358,Q5T0N5,Q9Y3E5,P33993,Q9BTE3 389 5.00e-02 19 12 1 0.083 0.053 REAC:5334118 rea 1 DNA methylation 1 P26358 389 5.00e-02 391 12 4 0.333 0.010 MI:mmu-miR-294 mi 1 MI:mmu-miR-294 1 P49736,P33991,P25205,P26358 389 5.00e-02 117 12 6 0.500 0.051 KEGG:04110 keg 1 Cell cycle 1 P49736,Q14566,P33992,P33991,P25205,P33993 390 4.17e-08 11 9 4 0.444 0.364 CORUM:5196 cor 1 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) 1 O75170,Q9UPN7,O00743,O15084 390 5.68e-07 54 9 4 0.444 0.074 GO:0048208 BP 1 COPII vesicle coating 1 Q9UPN7,Q5H9R7,O00743,O15084 390 5.68e-07 54 9 4 0.444 0.074 GO:0048207 BP 1 vesicle targeting, rough ER to cis-Golgi 1 Q9UPN7,Q5H9R7,O00743,O15084 390 6.60e-07 56 9 4 0.444 0.071 GO:0006901 BP 1 vesicle coating 1 Q9UPN7,Q5H9R7,O00743,O15084 390 7.09e-07 57 9 4 0.444 0.070 GO:0090114 BP 1 COPII-coated vesicle budding 1 Q9UPN7,Q5H9R7,O00743,O15084 390 8.16e-07 59 9 4 0.444 0.068 GO:0048199 BP 1 vesicle targeting, to, from or within Golgi 1 Q9UPN7,Q5H9R7,O00743,O15084 390 1.37e-06 67 9 4 0.444 0.060 GO:0006903 BP 1 vesicle targeting 1 Q9UPN7,Q5H9R7,O00743,O15084 390 1.42e-06 60 9 4 0.444 0.067 REAC:204005 rea 1 COPII (Coat Protein 2) Mediated Vesicle Transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 5.88e-06 96 9 4 0.444 0.042 GO:0006900 BP 1 membrane budding 1 Q9UPN7,Q5H9R7,O00743,O15084 390 2.23e-05 119 9 4 0.444 0.034 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 3.81e-05 153 9 4 0.444 0.026 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.50e-05 142 9 4 0.444 0.028 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 Q9UPN7,Q5H9R7,O00743,O15084 390 5.27e-05 166 9 4 0.444 0.024 GO:0051650 BP 1 establishment of vesicle localization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 6.50e-05 175 9 4 0.444 0.023 GO:0051648 BP 1 vesicle localization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.02e-04 248 9 4 0.444 0.016 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.05e-04 278 9 4 0.444 0.014 GO:0048193 BP 1 Golgi vesicle transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.22e-04 281 9 4 0.444 0.014 GO:0016050 BP 1 vesicle organization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.71e-04 289 9 4 0.444 0.014 GO:0051656 BP 1 establishment of organelle localization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 8.01e-04 331 9 4 0.444 0.012 GO:0051640 BP 1 organelle localization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 1.43e-03 138 9 3 0.333 0.022 GO:0006470 BP 1 protein dephosphorylation 1 Q9UPN7,Q5H9R7,O00743 390 1.72e-03 25 9 2 0.222 0.080 GO:0043666 BP 1 regulation of phosphoprotein phosphatase activity 1 Q9UPN7,Q5H9R7 390 1.80e-03 92 9 2 0.222 0.022 TF:M04400_1 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 1 1 Q8N8A2,Q92974 390 3.12e-03 449 9 3 0.333 0.007 TF:M04030_1 tf 1 Factor: MEIS3; motif: NTGACAGN; match class: 1 1 Q8N8A2,Q5H9R7,Q8NB46 390 3.53e-03 5 9 1 0.111 0.200 TF:M06900_0 tf 1 Factor: ZNF658; motif: GTGGTGGGACGAGGTGGG; match class: 0 1 O15091 390 4.24e-03 6 9 1 0.111 0.167 TF:M06180_1 tf 1 Factor: ZNF445; motif: NTGGGGGGAM; match class: 1 1 O75170 390 4.75e-03 458 9 3 0.333 0.007 MI:hsa-miR-223 mi 1 MI:hsa-miR-223 1 Q8N8A2,O75170,O15091 390 4.89e-03 153 9 2 0.222 0.013 TF:M03886_1 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 1 1 Q8N8A2,O15084 390 4.89e-03 526 9 3 0.333 0.006 TF:M03929_1 tf 1 Factor: ZBTB7C; motif: NCGACCACCGNN; match class: 1 1 O15091,Q5H9R7,O15084 390 5.14e-03 43 9 2 0.222 0.047 GO:0035304 BP 1 regulation of protein dephosphorylation 1 Q9UPN7,Q5H9R7 390 5.21e-03 1015 9 5 0.556 0.005 GO:0071822 BP 1 protein complex subunit organization 1 Q9UPN7,Q5H9R7,Q92974,O00743,O15084 390 5.58e-03 219 9 3 0.333 0.014 GO:0016311 BP 1 dephosphorylation 1 Q9UPN7,Q5H9R7,O00743 390 6.35e-03 9 9 1 0.111 0.111 TF:M06449_0 tf 1 Factor: znf567; motif: NAGGCAATCRGA; match class: 0 1 O75170 390 6.35e-03 9 9 1 0.111 0.111 TF:M05327_0 tf 1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 0 1 O15084 390 6.82e-03 522 9 4 0.444 0.008 REAC:199991 rea 1 Membrane Trafficking 1 Q9UPN7,Q5H9R7,O00743,O15084 390 7.30e-03 188 9 2 0.222 0.011 TF:M04400_0 tf 1 Factor: MEOX2; motif: NTAATTANNNTAATTAN; match class: 0 1 Q8N8A2,Q92974 390 7.75e-03 11 9 1 0.111 0.091 TF:M06097_0 tf 1 Factor: ZNF14; motif: KGTTRGAGRACM; match class: 0 1 O15091 390 8.22e-03 549 9 4 0.444 0.007 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 8.46e-03 12 9 1 0.111 0.083 TF:M06118_0 tf 1 Factor: ZNF23; motif: NGGTAAWGGTTN; match class: 0 1 O15084 390 1.13e-02 16 9 1 0.111 0.062 TF:M06016_0 tf 1 Factor: ZNF729; motif: KGGTGTGGAANA; match class: 0 1 O15091 390 1.15e-02 1395 9 4 0.444 0.003 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q92974,O00743,Q8NB46,O15084 390 1.31e-02 1237 9 5 0.556 0.004 GO:0046907 BP 1 intracellular transport 1 Q9UPN7,Q5H9R7,Q92974,O00743,O15084 390 1.36e-02 70 9 2 0.222 0.029 GO:0010921 BP 1 regulation of phosphatase activity 1 Q9UPN7,Q5H9R7 390 1.36e-02 4603 9 7 0.778 0.002 TF:M03924_0 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 0 1 Q8N8A2,O75170,O15091,Q5H9R7,Q92974,O00743,Q8NB46 390 1.40e-02 71 9 2 0.222 0.028 GO:0019903 MF 1 protein phosphatase binding 1 Q9UPN7,Q5H9R7 390 1.47e-02 6121 9 8 0.889 0.001 TF:M00695_1 tf 1 Factor: ETF; motif: GVGGMGG; match class: 1 1 Q8N8A2,O75170,O15091,Q9UPN7,Q5H9R7,O00743,Q8NB46,O15084 390 1.56e-02 3469 9 6 0.667 0.002 TF:M01877_0 tf 1 Factor: GATA-2; motif: GATAANN; match class: 0 1 Q8N8A2,O15091,Q9UPN7,Q92974,O00743,O15084 390 1.57e-02 280 9 2 0.222 0.007 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 Q5H9R7,O00743 390 1.67e-02 2 9 1 0.111 0.500 GO:0008627 BP 1 intrinsic apoptotic signaling pathway in response to osmotic stress 1 Q92974 390 1.67e-02 2 9 1 0.111 0.500 GO:1902219 BP 1 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 1 Q92974 390 1.67e-02 2 9 1 0.111 0.500 GO:0071474 BP 1 cellular hyperosmotic response 1 Q92974 390 1.67e-02 2 9 1 0.111 0.500 GO:1902218 BP 1 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 1 Q92974 390 1.83e-02 749 9 4 0.444 0.005 GO:0061024 BP 1 membrane organization 1 Q9UPN7,Q5H9R7,O00743,O15084 390 2.03e-02 29 9 1 0.111 0.034 TF:M05814_0 tf 1 Factor: ZNF605; motif: TGGGAATGGATN; match class: 0 1 Q8NB46 390 2.10e-02 1657 9 4 0.444 0.002 TF:M07312_0 tf 1 Factor: ATF-2; motif: NNTGACGTCAN; match class: 0 1 O75170,Q5H9R7,O00743,O15084 390 2.10e-02 30 9 1 0.111 0.033 TF:M00993_1 tf 1 Factor: Tal-1; motif: TCCAKCTGNY; match class: 1 1 Q92974 390 2.12e-02 712 9 4 0.444 0.006 REAC:597592 rea 1 Post-translational protein modification 1 Q9UPN7,Q5H9R7,O00743,O15084 390 2.19e-02 334 9 2 0.222 0.006 TF:M06180_0 tf 1 Factor: ZNF445; motif: NTGGGGGGAM; match class: 0 1 O75170,Q9UPN7 390 2.24e-02 338 9 2 0.222 0.006 TF:M03548_1 tf 1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 1 Q8N8A2,O15084 390 2.26e-02 1694 9 4 0.444 0.002 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 Q8N8A2,Q9UPN7,Q92974,O15084 390 2.31e-02 33 9 1 0.111 0.030 TF:M05741_0 tf 1 Factor: ZNF718; motif: NGGGGCWTCAGM; match class: 0 1 Q9UPN7 390 2.33e-02 1709 9 4 0.444 0.002 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q8N8A2,Q92974,O00743,Q8NB46 390 2.34e-02 92 9 2 0.222 0.022 GO:0035303 BP 1 regulation of dephosphorylation 1 Q9UPN7,Q5H9R7 390 2.40e-02 2674 9 5 0.556 0.002 TF:M07308_0 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 0 1 Q8N8A2,Q9UPN7,Q92974,Q8NB46,O15084 390 2.43e-02 311 9 2 0.222 0.006 MI:hsa-miR-431* mi 1 MI:hsa-miR-431* 1 Q92974,Q8NB46 390 2.43e-02 944 9 3 0.333 0.003 TF:M01657_0 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 0 1 O15091,Q5H9R7,Q8NB46 390 2.50e-02 3 9 1 0.111 0.333 GO:0006972 BP 1 hyperosmotic response 1 Q92974 390 2.50e-02 3 9 1 0.111 0.333 GO:0047484 BP 1 regulation of response to osmotic stress 1 Q92974 390 2.55e-02 8469 9 9 1.000 0.001 TF:M01250_0 tf 1 Factor: E2F-1; motif: CGTTTCNN; match class: 0 1 Q8N8A2,O75170,O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46,O15084 390 2.81e-02 101 9 2 0.222 0.020 GO:0019902 MF 1 phosphatase binding 1 Q9UPN7,Q5H9R7 390 2.82e-02 842 9 4 0.444 0.005 GO:0006461 BP 1 protein complex assembly 1 Q9UPN7,Q5H9R7,O00743,O15084 390 2.82e-02 842 9 4 0.444 0.005 GO:0070271 BP 1 protein complex biogenesis 1 Q9UPN7,Q5H9R7,O00743,O15084 390 2.94e-02 2262 9 6 0.667 0.003 GO:0006996 BP 1 organelle organization 1 O15091,Q9UPN7,Q5H9R7,Q92974,O00743,O15084 390 2.95e-02 1015 9 3 0.333 0.003 TF:M00339_1 tf 1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 1 Q8N8A2,Q92974,Q8NB46 390 3.06e-02 352 9 2 0.222 0.006 MI:hsa-miR-18b* mi 1 MI:hsa-miR-18b* 1 O15091,Q8NB46 390 3.07e-02 44 9 1 0.111 0.023 TF:M00139_0 tf 1 Factor: AhR; motif: CCYCNRRSTNGCGTGASA; match class: 0 1 Q8NB46 390 3.07e-02 6782 9 8 0.889 0.001 TF:M01034_0 tf 1 Factor: Ebox; motif: NCACSTGNCN; match class: 0 1 Q8N8A2,O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46,O15084 390 3.10e-02 1493 9 5 0.556 0.003 GO:0051649 BP 1 establishment of localization in cell 1 Q9UPN7,Q5H9R7,Q92974,O00743,O15084 390 3.19e-02 1046 9 3 0.333 0.003 TF:M00262_0 tf 1 Factor: Staf; motif: NTTWCCCANMATGCAYYRCGNY; match class: 0 1 Q8N8A2,O15091,Q8NB46 390 3.23e-02 362 9 2 0.222 0.006 MI:hsa-miR-34b* mi 1 MI:hsa-miR-34b* 1 O75170,O15091 390 3.28e-02 47 9 1 0.111 0.021 TF:M00001_1 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 1 1 O15091 390 3.34e-02 4 9 1 0.111 0.250 GO:0071225 BP 1 cellular response to muramyl dipeptide 1 Q92974 390 3.53e-02 1087 9 3 0.333 0.003 TF:M00178_0 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 0 1 Q5H9R7,O00743,O15084 390 3.66e-02 5433 9 7 0.778 0.001 TF:M00162_0 tf 1 Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 0 1 O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46,O15084 390 3.73e-02 445 9 2 0.222 0.004 TF:M02044_0 tf 1 Factor: YY1; motif: GCCGCCATTTTG; match class: 0 1 O75170,Q5H9R7 390 3.74e-02 392 9 2 0.222 0.005 MI:hsa-miR-551a mi 1 MI:hsa-miR-551a 1 O75170,Q92974 390 3.76e-02 54 9 1 0.111 0.019 TF:M06273_0 tf 1 Factor: ZNF766; motif: KGTGCGGKCCGA; match class: 0 1 Q9UPN7 390 3.93e-02 458 9 2 0.222 0.004 TF:M06222_0 tf 1 Factor: ZNF273; motif: KGKGGCTACYSA; match class: 0 1 O15091,Q92974 390 3.95e-02 3018 9 5 0.556 0.002 TF:M01863_0 tf 1 Factor: ATF-3; motif: RTKRCGTCANN; match class: 0 1 Q8N8A2,O75170,Q92974,O00743,O15084 390 4.00e-02 462 9 2 0.222 0.004 TF:M04424_0 tf 1 Factor: PDX1; motif: NYAATTARNNNTAATTAN; match class: 0 1 O15091,O15084 390 4.03e-02 58 9 1 0.111 0.017 TF:M04424_1 tf 1 Factor: PDX1; motif: NYAATTARNNNTAATTAN; match class: 1 1 O15084 390 4.13e-02 3052 9 5 0.556 0.002 TF:M07284_1 tf 1 Factor: Erg; motif: MCAGGAAA; match class: 1 1 O15091,Q5H9R7,Q92974,Q8NB46,O15084 390 4.17e-02 5 9 1 0.111 0.200 GO:0060546 BP 1 negative regulation of necroptotic process 1 Q92974 390 4.17e-02 5 9 1 0.111 0.200 GO:0060547 BP 1 negative regulation of necrotic cell death 1 Q92974 390 4.29e-02 5583 9 7 0.778 0.001 TF:M00430_0 tf 1 Factor: E2F-1; motif: NTTSGCGG; match class: 0 1 Q8N8A2,O15091,Q9UPN7,Q5H9R7,O00743,Q8NB46,O15084 390 4.31e-02 7114 9 8 0.889 0.001 TF:M07056_1 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 1 1 O75170,O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46,O15084 390 4.31e-02 7114 9 8 0.889 0.001 TF:M02114_1 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 1 1 O75170,O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46,O15084 390 4.37e-02 63 9 1 0.111 0.016 TF:M06611_0 tf 1 Factor: ZNF560; motif: NNGTGGGKCAGC; match class: 0 1 Q92974 390 4.37e-02 63 9 1 0.111 0.016 TF:M06189_0 tf 1 Factor: ZNF91; motif: KGKTAGGRCAKA; match class: 0 1 O15091 390 4.38e-02 1182 9 3 0.333 0.003 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 O75170,Q5H9R7,O00743 390 4.38e-02 486 9 2 0.222 0.004 TF:M00178_1 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 1 1 O00743,O15084 390 4.40e-02 1614 9 5 0.556 0.003 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q9UPN7,Q5H9R7,Q92974,O00743,O15084 390 4.41e-02 5610 9 7 0.778 0.001 TF:M07042_0 tf 1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 0 1 Q8N8A2,O75170,O15091,Q9UPN7,Q5H9R7,Q8NB46,O15084 390 4.54e-02 958 9 4 0.444 0.004 GO:0016192 BP 1 vesicle-mediated transport 1 Q9UPN7,Q5H9R7,O00743,O15084 390 4.64e-02 441 9 2 0.222 0.005 MI:hsa-miR-650 mi 1 MI:hsa-miR-650 1 O75170,O15091 390 4.74e-02 1219 9 3 0.333 0.002 TF:M07435_1 tf 1 Factor: TWIST; motif: MNACACNTGGN; match class: 1 1 O75170,Q9UPN7,Q5H9R7 390 4.75e-02 447 9 2 0.222 0.004 MI:hsa-miR-522 mi 1 MI:hsa-miR-522 1 Q8N8A2,O15091 390 4.81e-02 450 9 2 0.222 0.004 MI:hsa-miR-184 mi 1 MI:hsa-miR-184 1 O15091,Q92974 390 4.93e-02 2140 9 4 0.444 0.002 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 O75170,O15091,Q9UPN7,Q8NB46 390 4.96e-02 5725 9 7 0.778 0.001 TF:M00280_0 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 0 1 Q8N8A2,O15091,Q9UPN7,Q5H9R7,Q92974,O00743,Q8NB46 390 5.00e-02 6 9 1 0.111 0.167 GO:0032495 BP 1 response to muramyl dipeptide 1 Q92974 390 5.00e-02 15 9 1 0.111 0.067 REAC:6785470 rea 1 tRNA processing in the mitochondrion 1 O15091 390 5.00e-02 11 9 1 0.111 0.091 CORUM:3075 cor 1 UTX-MLL2/3 complex 1 Q5H9R7 391 5.51e-04 66 3 2 0.667 0.030 REAC:380284 rea 1 Loss of proteins required for interphase microtubule organization__from the centrosome 1 Q5JTW2,O95684 391 5.51e-04 66 3 2 0.667 0.030 REAC:380259 rea 1 Loss of Nlp from mitotic centrosomes 1 Q5JTW2,O95684 391 5.58e-04 409 3 3 1.000 0.007 GO:0005813 CC 1 centrosome 1 Q5JTW2,Q96LK0,O95684 391 6.02e-04 69 3 2 0.667 0.029 REAC:8854518 rea 1 AURKA Activation by TPX2 1 Q5JTW2,O95684 391 7.12e-04 75 3 2 0.667 0.027 REAC:380287 rea 1 Centrosome maturation 1 Q5JTW2,O95684 391 7.12e-04 75 3 2 0.667 0.027 REAC:380270 rea 1 Recruitment of mitotic centrosome proteins and complexes 1 Q5JTW2,O95684 391 8.70e-04 474 3 3 1.000 0.006 GO:0005815 CC 1 microtubule organizing center 1 Q5JTW2,Q96LK0,O95684 391 8.72e-04 83 3 2 0.667 0.024 REAC:2565942 rea 1 Regulation of PLK1 Activity at G2/M Transition 1 Q5JTW2,O95684 391 1.07e-03 92 3 2 0.667 0.022 REAC:5620912 rea 1 Anchoring of the basal body to the plasma membrane 1 Q5JTW2,O95684 391 2.55e-03 1739 3 3 1.000 0.002 TF:M07042_1 tf 1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 1 Q5JTW2,Q96LK0,O95684 391 3.19e-03 420 3 2 0.667 0.005 TF:M06171_0 tf 1 Factor: ZNF138; motif: NCTGGCAAGANA; match class: 0 1 Q96LK0,O95684 391 3.69e-03 171 3 2 0.667 0.012 REAC:69275 rea 1 G2/M Transition 1 Q5JTW2,O95684 391 3.72e-03 769 3 3 1.000 0.004 GO:0015630 CC 1 microtubule cytoskeleton 1 Q5JTW2,Q96LK0,O95684 391 3.78e-03 173 3 2 0.667 0.012 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 Q5JTW2,O95684 391 3.78e-03 173 3 2 0.667 0.012 REAC:5617833 rea 1 Assembly of the primary cilium 1 Q5JTW2,O95684 391 4.68e-03 510 3 2 0.667 0.004 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 Q5JTW2,Q96LK0 391 5.18e-03 22 3 1 0.333 0.045 TF:M06256_0 tf 1 Factor: ZNF177; motif: NCYGGCGGRYCC; match class: 0 1 O95684 391 6.12e-03 26 3 1 0.333 0.038 TF:M05679_0 tf 1 Factor: ZNF816A; motif: KGGGGGGYCAGA; match class: 0 1 Q96LK0 391 6.64e-03 154 3 2 0.667 0.013 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 Q5JTW2,O95684 391 6.66e-03 933 3 3 1.000 0.003 GO:0044430 CC 1 cytoskeletal part 1 Q5JTW2,Q96LK0,O95684 391 6.83e-03 618 3 2 0.667 0.003 TF:M01798_1 tf 1 Factor: RPC155; motif: TCMNGRGTTCRAGWCC; match class: 1 1 Q5JTW2,Q96LK0 391 7.26e-03 161 3 2 0.667 0.012 GO:0044839 BP 1 cell cycle G2/M phase transition 1 Q5JTW2,O95684 391 9.68e-03 738 3 2 0.667 0.003 TF:M06537_0 tf 1 Factor: CTCFL; motif: NSGTGGGCGG; match class: 0 1 Q96LK0,O95684 391 1.22e-02 52 3 1 0.333 0.019 TF:M07123_1 tf 1 Factor: rfx5; motif: YNSCMTRGCAACAGN; match class: 1 1 Q96LK0 391 1.23e-02 314 3 2 0.667 0.006 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 Q5JTW2,O95684 391 1.31e-02 4 3 1 0.333 0.250 GO:0030292 MF 1 protein tyrosine kinase inhibitor activity 1 O95684 391 1.31e-02 56 3 1 0.333 0.018 TF:M00447_1 tf 1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 1 O95684 391 1.34e-02 57 3 1 0.333 0.018 TF:M05912_0 tf 1 Factor: FLJ20557; motif: NGGKGYTAMASA; match class: 0 1 Q5JTW2 391 1.43e-02 1204 3 3 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 Q5JTW2,Q96LK0,O95684 391 1.50e-02 64 3 1 0.333 0.016 TF:M06002_0 tf 1 Factor: ZNF257; motif: NGGGWGGGCARM; match class: 0 1 Q96LK0 391 1.57e-02 67 3 1 0.333 0.015 TF:M06624_0 tf 1 Factor: ZNF2; motif: NSATCGATCCGA; match class: 0 1 Q5JTW2 391 1.68e-02 18 3 1 0.333 0.056 REAC:1839117 rea 1 Signaling by cytosolic FGFR1 fusion mutants 1 O95684 391 1.71e-02 3282 3 3 1.000 0.001 TF:M07326_0 tf 1 Factor: Mef-2A; motif: YTATWTTTARNNC; match class: 0 1 Q5JTW2,Q96LK0,O95684 391 1.81e-02 1016 3 2 0.667 0.002 TF:M06727_0 tf 1 Factor: PRDM6; motif: GGTACCAM; match class: 0 1 Q96LK0,O95684 391 1.90e-02 1042 3 2 0.667 0.002 TF:M00672_0 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 0 1 Q96LK0,O95684 391 2.03e-02 1078 3 2 0.667 0.002 TF:M00414_1 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 1 1 Q5JTW2,Q96LK0 391 2.04e-02 87 3 1 0.333 0.011 TF:M06079_0 tf 1 Factor: ZNF276; motif: NNGGAAAGACGC; match class: 0 1 Q5JTW2 391 2.08e-02 1091 3 2 0.667 0.002 TF:M00302_1 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 1 1 Q96LK0,O95684 391 2.09e-02 3506 3 3 1.000 0.001 TF:M07249_0 tf 1 Factor: ctcf; motif: CCNCNAGRKGGCRSTN; match class: 0 1 Q5JTW2,Q96LK0,O95684 391 2.22e-02 95 3 1 0.333 0.011 TF:M06111_0 tf 1 Factor: ZNF254; motif: NGKTGCGGACGM; match class: 0 1 Q96LK0 391 2.23e-02 4 3 1 0.333 0.250 HP:0003141 hp 1 Hyperbetalipoproteinemia 1 Q96LK0 391 2.23e-02 4 3 1 0.333 0.250 HP:0000798 hp 1 Oligospermia 1 Q96LK0 391 2.32e-02 25 3 1 0.333 0.040 REAC:1839124 rea 1 FGFR1 mutant receptor activation 1 O95684 391 2.48e-02 1195 3 2 0.667 0.002 TF:M01149_0 tf 1 Factor: DMRT4; motif: AATGTADCAAWTT; match class: 0 1 Q5JTW2,Q96LK0 391 2.48e-02 448 3 2 0.667 0.004 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q5JTW2,O95684 391 2.58e-02 3760 3 3 1.000 0.001 TF:M01072_1 tf 1 Factor: HIC1; motif: NSNNNNTGCCCSSNN; match class: 1 1 Q5JTW2,Q96LK0,O95684 391 2.87e-02 123 3 1 0.333 0.008 TF:M06483_0 tf 1 Factor: ZNF595; motif: NGTGGAGGAWGC; match class: 0 1 O95684 391 2.95e-02 1307 3 2 0.667 0.002 TF:M00793_0 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 0 1 Q96LK0,O95684 391 2.97e-02 32 3 1 0.333 0.031 REAC:5655302 rea 1 Signaling by FGFR1 in disease 1 O95684 391 3.04e-02 3971 3 3 1.000 0.001 TF:M03565_0 tf 1 Factor: slug; motif: KCACCTGN; match class: 0 1 Q5JTW2,Q96LK0,O95684 391 3.08e-02 1338 3 2 0.667 0.001 TF:M07054_1 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 1 Q5JTW2,Q96LK0 391 3.15e-02 135 3 1 0.333 0.007 TF:M01013_1 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 1 1 Q5JTW2 391 3.38e-02 145 3 1 0.333 0.007 TF:M01723_0 tf 1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 0 1 Q96LK0 391 3.61e-02 1453 3 2 0.667 0.001 TF:M04203_0 tf 1 Factor: CEBPE; motif: NTTRCGCAAY; match class: 0 1 Q5JTW2,O95684 391 3.63e-02 156 3 1 0.333 0.006 TF:M01147_0 tf 1 Factor: DMRT2; motif: NAWWTTGWTACATTGW; match class: 0 1 Q96LK0 391 3.66e-02 547 3 2 0.667 0.004 REAC:1640170 rea 1 Cell Cycle 1 Q5JTW2,O95684 391 3.91e-02 168 3 1 0.333 0.006 TF:M06322_0 tf 1 Factor: ZNF181; motif: NCGGAAAGACGC; match class: 0 1 Q5JTW2 391 3.96e-02 1524 3 2 0.667 0.001 TF:M07416_1 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 1 1 Q96LK0,O95684 391 4.02e-02 173 3 1 0.333 0.006 TF:M01305_0 tf 1 Factor: TEF; motif: YACATTCCWSNG; match class: 0 1 Q5JTW2 391 4.51e-02 1633 3 2 0.667 0.001 TF:M04474_0 tf 1 Factor: NR2F1; motif: GRGGTCAN; match class: 0 1 Q96LK0,O95684 391 4.68e-02 411 3 2 0.667 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q5JTW2,O95684 391 4.69e-02 1666 3 2 0.667 0.001 TF:M04281_1 tf 1 Factor: ALX4; motif: NTAATYNAATTAN; match class: 1 1 Q96LK0,O95684 391 5.00e-02 425 3 2 0.667 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q5JTW2,O95684 391 5.00e-02 54 3 1 0.333 0.019 REAC:1226099 rea 1 Signaling by FGFR in disease 1 O95684 391 5.00e-02 1 3 1 0.333 1.000 OMIM:615703 omi 1 MORBID OBESITY AND SPERMATOGENIC FAILURE; MOSPGF 1 Q96LK0 391 5.00e-02 397 3 2 0.667 0.005 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 Q5JTW2,O95684 391 5.00e-02 9 3 1 0.333 0.111 HP:0003233 hp 1 Hypoalphalipoproteinemia 1 Q96LK0 392 3.56e-07 3 3 2 0.667 0.667 GO:0005785 CC 1 signal recognition particle receptor complex 1 Q9Y5M8,P08240 392 1.19e-06 5 3 2 0.667 0.400 GO:0005047 MF 1 signal recognition particle binding 1 Q9Y5M8,P08240 392 4.27e-06 9 3 2 0.667 0.222 GO:0030867 CC 1 rough endoplasmic reticulum membrane 1 Q9Y5M8,P08240 392 4.47e-05 28 3 2 0.667 0.071 GO:0005791 CC 1 rough endoplasmic reticulum 1 Q9Y5M8,P08240 392 2.09e-04 60 3 2 0.667 0.033 GO:0036498 BP 1 IRE1-mediated unfolded protein response 1 Q9Y5M8,P08240 392 2.46e-04 65 3 2 0.667 0.031 GO:0043021 MF 1 ribonucleoprotein complex binding 1 Q9Y5M8,P08240 392 2.51e-04 528 3 3 1.000 0.006 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q9Y5M8,O15320,P08240 392 2.59e-04 534 3 3 1.000 0.006 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q9Y5M8,O15320,P08240 392 4.86e-04 658 3 3 1.000 0.005 GO:0044432 CC 1 endoplasmic reticulum part 1 Q9Y5M8,O15320,P08240 392 5.38e-04 96 3 2 0.667 0.021 GO:0030968 BP 1 endoplasmic reticulum unfolded protein response 1 Q9Y5M8,P08240 392 5.60e-04 98 3 2 0.667 0.020 GO:0006613 BP 1 cotranslational protein targeting to membrane 1 Q9Y5M8,P08240 392 5.72e-04 99 3 2 0.667 0.020 GO:0034620 BP 1 cellular response to unfolded protein 1 Q9Y5M8,P08240 392 6.02e-04 49 3 2 0.667 0.041 REAC:381038 rea 1 XBP1(S) activates chaperone genes 1 Q9Y5M8,P08240 392 6.08e-04 709 3 3 1.000 0.004 GO:0006886 BP 1 intracellular protein transport 1 Q9Y5M8,O15320,P08240 392 6.53e-04 51 3 2 0.667 0.039 REAC:381070 rea 1 IRE1alpha activates chaperones 1 Q9Y5M8,P08240 392 7.45e-04 113 3 2 0.667 0.018 GO:0035967 BP 1 cellular response to topologically incorrect protein 1 Q9Y5M8,P08240 392 8.13e-04 118 3 2 0.667 0.017 GO:0070972 BP 1 protein localization to endoplasmic reticulum 1 Q9Y5M8,O15320 392 8.55e-04 121 3 2 0.667 0.017 GO:0006986 BP 1 response to unfolded protein 1 Q9Y5M8,P08240 392 1.10e-03 137 3 2 0.667 0.015 GO:0035966 BP 1 response to topologically incorrect protein 1 Q9Y5M8,P08240 392 1.37e-03 2 3 1 0.333 0.500 GO:1905097 BP 1 regulation of guanyl-nucleotide exchange factor activity 1 O15320 392 1.39e-03 933 3 3 1.000 0.003 GO:0005783 CC 1 endoplasmic reticulum 1 Q9Y5M8,O15320,P08240 392 1.40e-03 155 3 2 0.667 0.013 GO:0006612 BP 1 protein targeting to membrane 1 Q9Y5M8,P08240 392 1.53e-03 964 3 3 1.000 0.003 GO:0015031 BP 1 protein transport 1 Q9Y5M8,O15320,P08240 392 1.53e-03 78 3 2 0.667 0.026 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 Q9Y5M8,P08240 392 2.27e-03 1100 3 3 1.000 0.003 GO:0045184 BP 1 establishment of protein localization 1 Q9Y5M8,O15320,P08240 392 2.34e-03 1111 3 3 1.000 0.003 GO:0034613 BP 1 cellular protein localization 1 Q9Y5M8,O15320,P08240 392 2.41e-03 1121 3 3 1.000 0.003 GO:0070727 BP 1 cellular macromolecule localization 1 Q9Y5M8,O15320,P08240 392 2.55e-03 209 3 2 0.667 0.010 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 Q9Y5M8,P08240 392 2.73e-03 4 3 1 0.333 0.250 GO:0070973 BP 1 protein localization to endoplasmic reticulum exit site 1 O15320 392 3.11e-03 111 3 2 0.667 0.018 REAC:1799339 rea 1 SRP-dependent cotranslational protein targeting to membrane 1 Q9Y5M8,P08240 392 3.24e-03 1237 3 3 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 Q9Y5M8,O15320,P08240 392 4.46e-03 1377 3 3 1.000 0.002 GO:0071702 BP 1 organic substance transport 1 Q9Y5M8,O15320,P08240 392 4.62e-03 1393 3 3 1.000 0.002 GO:0008104 BP 1 protein localization 1 Q9Y5M8,O15320,P08240 392 4.78e-03 7 3 1 0.333 0.143 GO:0035459 BP 1 cargo loading into vesicle 1 O15320 392 4.89e-03 290 3 2 0.667 0.007 GO:0090150 BP 1 establishment of protein localization to membrane 1 Q9Y5M8,P08240 392 5.69e-03 1493 3 3 1.000 0.002 GO:0051649 BP 1 establishment of localization in cell 1 Q9Y5M8,O15320,P08240 392 5.75e-03 1498 3 3 1.000 0.002 GO:0044765 BP 1 single-organism transport 1 Q9Y5M8,O15320,P08240 392 6.05e-03 155 3 2 0.667 0.013 REAC:72766 rea 1 Translation 1 Q9Y5M8,P08240 392 7.24e-03 1618 3 3 1.000 0.002 GO:0033036 BP 1 macromolecule localization 1 Q9Y5M8,O15320,P08240 392 7.51e-03 11 3 1 0.333 0.091 GO:0070971 CC 1 endoplasmic reticulum exit site 1 O15320 392 7.71e-03 1652 3 3 1.000 0.002 GO:1902578 BP 1 single-organism localization 1 Q9Y5M8,O15320,P08240 392 7.88e-03 369 3 2 0.667 0.005 GO:0072657 BP 1 protein localization to membrane 1 Q9Y5M8,P08240 392 1.06e-02 1836 3 3 1.000 0.002 GO:0051641 BP 1 cellular localization 1 Q9Y5M8,O15320,P08240 392 1.14e-02 444 3 2 0.667 0.005 GO:0098796 CC 1 membrane protein complex 1 Q9Y5M8,P08240 392 1.34e-02 6 3 1 0.333 0.167 TF:M04264_0 tf 1 Factor: FOXO6; motif: GTAAACATGTTTAC; match class: 0 1 P08240 392 1.36e-02 487 3 2 0.667 0.004 GO:0006605 BP 1 protein targeting 1 Q9Y5M8,P08240 392 1.51e-02 296 3 2 0.667 0.007 TF:M00516_0 tf 1 Factor: E2F; motif: TTTSGCGCGMNR; match class: 0 1 O15320,P08240 392 1.89e-02 574 3 2 0.667 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 Q9Y5M8,P08240 392 1.89e-02 1169 3 3 1.000 0.003 REAC:392499 rea 1 Metabolism of proteins 1 Q9Y5M8,O15320,P08240 392 1.98e-02 2260 3 3 1.000 0.001 GO:0012505 CC 1 endomembrane system 1 Q9Y5M8,O15320,P08240 392 2.26e-02 630 3 2 0.667 0.003 GO:0044802 BP 1 single-organism membrane organization 1 Q9Y5M8,P08240 392 2.28e-02 1707 3 3 1.000 0.002 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q9Y5M8,O15320,P08240 392 2.39e-02 35 3 1 0.333 0.029 GO:0005881 CC 1 cytoplasmic microtubule 1 Q9Y5M8 392 2.40e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 Q9Y5M8,O15320,P08240 392 2.46e-02 657 3 2 0.667 0.003 GO:0033365 BP 1 protein localization to organelle 1 Q9Y5M8,O15320 392 2.59e-02 38 3 1 0.333 0.026 GO:0032527 BP 1 protein exit from endoplasmic reticulum 1 O15320 392 2.71e-02 690 3 2 0.667 0.003 GO:0044877 MF 1 macromolecular complex binding 1 Q9Y5M8,P08240 392 3.16e-02 2644 3 3 1.000 0.001 GO:0006810 BP 1 transport 1 Q9Y5M8,O15320,P08240 392 3.18e-02 749 3 2 0.667 0.003 GO:0061024 BP 1 membrane organization 1 Q9Y5M8,P08240 392 3.36e-02 771 3 2 0.667 0.003 GO:1902580 BP 1 single-organism cellular localization 1 Q9Y5M8,P08240 392 3.55e-02 2748 3 3 1.000 0.001 GO:0051234 BP 1 establishment of localization 1 Q9Y5M8,O15320,P08240 392 5.00e-02 27 3 1 0.333 0.037 REAC:5694530 rea 1 Cargo concentration in the ER 1 O15320 392 5.00e-02 945 3 2 0.667 0.002 GO:0098588 CC 1 bounding membrane of organelle 1 Q9Y5M8,P08240 392 5.00e-02 22 3 2 0.667 0.091 KEGG:03060 keg 1 Protein export 1 Q9Y5M8,P08240 392 5.00e-02 2216 3 3 1.000 0.001 TF:M00740_0 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 0 1 Q9Y5M8,O15320,P08240 393 1.96e-03 1 5 1 0.200 1.000 OMIM:613850 omi 1 INOSINE TRIPHOSPHATASE DEFICIENCY;;INOSINE TRIPHOSPHATE PYROPHOSPHOHYDROLASE DEFICIENCY 1 Q9BY32 393 1.96e-03 1 5 1 0.200 1.000 OMIM:615816 omi 1 IMMUNODEFICIENCY 23; IMD23;;IMMUNODEFICIENCY WITH HYPER IgE AND COGNITIVE IMPAIRMENT;;IMMUNODEFICIENCY-VASCULITIS-MYOCLONUS SYNDROME; IVMS 1 O95394 393 1.96e-03 1 5 1 0.200 1.000 OMIM:616647 omi 1 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 35; EIEE35 1 Q9BY32 393 2.04e-03 774 5 3 0.600 0.004 TF:M03914_1 tf 1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 1 O95394,Q6YP21,Q5T013 393 2.75e-03 7 5 1 0.200 0.143 TF:M06531_1 tf 1 Factor: ZNF555; motif: NCRWGTTTGKCC; match class: 1 1 Q5T013 393 2.80e-03 217 5 2 0.400 0.009 TF:M00141_1 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 1 1 O95394,Q53H82 393 3.14e-03 8 5 1 0.200 0.125 TF:M06540_0 tf 1 Factor: znf540; motif: NTGTCCATATTC; match class: 0 1 Q5T013 393 4.55e-03 1 5 1 0.200 1.000 GO:0036222 MF 1 XTP diphosphatase activity 1 Q9BY32 393 4.55e-03 1 5 1 0.200 1.000 GO:0047315 MF 1 kynurenine-glyoxylate transaminase activity 1 Q6YP21 393 4.55e-03 1 5 1 0.200 1.000 GO:0004610 MF 1 phosphoacetylglucosamine mutase activity 1 O95394 393 4.55e-03 1 5 1 0.200 1.000 GO:0036220 MF 1 ITP diphosphatase activity 1 Q9BY32 393 5.28e-03 300 5 2 0.400 0.007 TF:M01182_0 tf 1 Factor: MIZF; motif: CGGACGTT; match class: 0 1 O95394,Q9BY32 393 6.66e-03 17 5 1 0.200 0.059 TF:M04331_0 tf 1 Factor: HESX1; motif: NTAATTGGYAATTAN; match class: 0 1 O95394 393 7.05e-03 18 5 1 0.200 0.056 TF:M06417_0 tf 1 Factor: ZNF771; motif: KGGTAAAAACCA; match class: 0 1 Q9BY32 393 7.14e-03 350 5 2 0.400 0.006 TF:M01770_0 tf 1 Factor: XBP-1; motif: WNNGMCACGTC; match class: 0 1 O95394,Q6YP21 393 9.11e-03 2 5 1 0.200 0.500 GO:0035870 MF 1 dITP diphosphatase activity 1 Q9BY32 393 9.11e-03 2 5 1 0.200 0.500 GO:0006041 BP 1 glucosamine metabolic process 1 O95394 393 1.05e-02 427 5 2 0.400 0.005 TF:M03890_1 tf 1 Factor: TFEA; motif: GYCASVTGACYN; match class: 1 1 Q9BY32,Q53H82 393 1.12e-02 4399 5 5 1.000 0.001 HPA:021020_02 hpa 1 liver; hepatocytes[Uncertain,Medium] 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 1.25e-02 1 5 1 0.200 1.000 HP:0040148 hp 1 Cortical myoclonus 1 O95394 393 1.26e-02 3003 5 4 0.800 0.001 TF:M00432_1 tf 1 Factor: TTF1; motif: ASTCAAGTRK; match class: 1 1 O95394,Q9BY32,Q6YP21,Q53H82 393 1.29e-02 475 5 2 0.400 0.004 TF:M00332_0 tf 1 Factor: Whn; motif: ANNGACGCTNN; match class: 0 1 O95394,Q9BY32 393 1.30e-02 1048 5 4 0.800 0.004 KEGG:01100 keg 1 Metabolic pathways 1 O95394,Q9BY32,Q6YP21,Q5T013 393 1.37e-02 3 5 1 0.200 0.333 GO:0036137 MF 1 kynurenine aminotransferase activity 1 Q6YP21 393 1.37e-02 3 5 1 0.200 0.333 GO:0016212 MF 1 kynurenine-oxoglutarate transaminase activity 1 Q6YP21 393 1.41e-02 36 5 1 0.200 0.028 TF:M05565_0 tf 1 Factor: ZNF772; motif: KGGTATGCCAKA; match class: 0 1 Q5T013 393 1.50e-02 5496 5 5 1.000 0.001 TF:M02110_0 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 1.72e-02 44 5 1 0.200 0.023 TF:M04406_0 tf 1 Factor: MSX2; motif: GCAATTAAAWWSCAATTA; match class: 0 1 O95394 393 1.83e-02 47 5 1 0.200 0.021 TF:M06752_0 tf 1 Factor: ZN337; motif: KGGGTAGGAAGA; match class: 0 1 Q53H82 393 1.87e-02 48 5 1 0.200 0.021 TF:M05921_0 tf 1 Factor: ZFP14; motif: KGGTGAAAAATA; match class: 0 1 O95394 393 1.88e-02 4876 5 5 1.000 0.001 HPA:039040 hpa 1 soft tissue 1; peripheral nerve 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 1.88e-02 578 5 2 0.400 0.003 TF:M04013_1 tf 1 Factor: HSFY1; motif: TTCGAANSRTTCGAA; match class: 1 1 Q6YP21,Q5T013 393 1.91e-02 49 5 1 0.200 0.020 TF:M03789_1 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 1 1 Q53H82 393 2.24e-02 634 5 2 0.400 0.003 TF:M00413_1 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 1 1 Q9BY32,Q5T013 393 2.36e-02 3555 5 4 0.800 0.001 TF:M07059_1 tf 1 Factor: POU2F1; motif: ATGCAAATN; match class: 1 1 O95394,Q6YP21,Q53H82,Q5T013 393 2.41e-02 62 5 1 0.200 0.016 TF:M04055_0 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 0 1 Q6YP21 393 2.41e-02 62 5 1 0.200 0.016 TF:M04055_1 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 1 1 Q6YP21 393 2.49e-02 3608 5 4 0.800 0.001 TF:M00032_1 tf 1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 1 O95394,Q9BY32,Q6YP21,Q5T013 393 2.50e-02 2 5 1 0.200 0.500 HP:0200029 hp 1 Vasculitis in the skin 1 O95394 393 2.57e-02 681 5 2 0.400 0.003 TF:M00927_1 tf 1 Factor: AP-4; motif: RNCAGCTGC; match class: 1 1 O95394,Q5T013 393 2.61e-02 1897 5 3 0.600 0.002 TF:M00733_0 tf 1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 0 1 O95394,Q6YP21,Q5T013 393 2.68e-02 16 5 1 0.200 0.062 KEGG:00450 keg 1 Selenocompound metabolism 1 Q6YP21 393 2.68e-02 1916 5 3 0.600 0.002 TF:M03812_1 tf 1 Factor: arnt; motif: CACGYA; match class: 1 1 O95394,Q6YP21,Q53H82 393 2.73e-02 6 5 1 0.200 0.167 GO:0070189 BP 1 kynurenine metabolic process 1 Q6YP21 393 2.78e-02 6218 5 5 1.000 0.001 TF:M03557_0 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 2.82e-02 6235 5 5 1.000 0.001 TF:M07329_0 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 2.91e-02 75 5 1 0.200 0.013 TF:M06020_0 tf 1 Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 0 1 Q5T013 393 2.99e-02 77 5 1 0.200 0.013 TF:M06650_0 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 0 1 Q53H82 393 2.99e-02 77 5 1 0.200 0.013 TF:M04391_0 tf 1 Factor: LHX9; motif: TAATTGCYAATTA; match class: 0 1 O95394 393 3.14e-02 758 5 2 0.400 0.003 TF:M04318_1 tf 1 Factor: EN2; motif: NNYAATTANN; match class: 1 1 O95394,Q53H82 393 3.26e-02 3879 5 4 0.800 0.001 TF:M03873_0 tf 1 Factor: HOXA10; motif: ANTTTATG; match class: 0 1 O95394,Q6YP21,Q53H82,Q5T013 393 3.30e-02 6433 5 5 1.000 0.001 TF:M00724_0 tf 1 Factor: HNF3alpha; motif: TRTTTGYTYWN; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 3.37e-02 87 5 1 0.200 0.011 TF:M01045_1 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 1 1 Q5T013 393 3.64e-02 8 5 1 0.200 0.125 GO:0047429 MF 1 nucleoside-triphosphate diphosphatase activity 1 Q9BY32 393 3.64e-02 3999 5 4 0.800 0.001 TF:M07255_1 tf 1 Factor: Foxm1; motif: NTGTTTRT; match class: 1 1 Q9BY32,Q6YP21,Q53H82,Q5T013 393 3.65e-02 2144 5 3 0.600 0.001 TF:M00924_1 tf 1 Factor: AP-1; motif: TGACTCANNSKN; match class: 1 1 Q6YP21,Q53H82,Q5T013 393 3.66e-02 2146 5 3 0.600 0.001 TF:M02099_1 tf 1 Factor: MITF; motif: CATGTGM; match class: 1 1 O95394,Q6YP21,Q53H82 393 3.74e-02 6597 5 5 1.000 0.001 TF:M03891_0 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82,Q5T013 393 3.75e-02 3 5 1 0.200 0.333 HP:0003193 hp 1 Allergic rhinitis 1 O95394 393 3.93e-02 2204 5 3 0.600 0.001 TF:M01029_0 tf 1 Factor: TFE; motif: TCATGTGN; match class: 0 1 O95394,Q53H82,Q5T013 393 3.94e-02 102 5 1 0.200 0.010 TF:M04172_0 tf 1 Factor: HEY1; motif: GRCACGTGCC; match class: 0 1 Q9BY32 393 3.94e-02 102 5 1 0.200 0.010 TF:M04173_0 tf 1 Factor: HEY2; motif: GNCACGTGYN; match class: 0 1 Q9BY32 393 3.98e-02 103 5 1 0.200 0.010 TF:M01279_1 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 1 Q6YP21 393 4.10e-02 106 5 1 0.200 0.009 TF:M06254_0 tf 1 Factor: znf267; motif: NGCWACTGGCGC; match class: 0 1 O95394 393 4.13e-02 107 5 1 0.200 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 O95394 393 4.19e-02 3523 5 4 0.800 0.001 HPA:039040_01 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Low] 1 Q9BY32,Q6YP21,Q53H82,Q5T013 393 4.24e-02 2266 5 3 0.600 0.001 TF:M00687_0 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 0 1 O95394,Q9BY32,Q53H82 393 4.41e-02 4212 5 4 0.800 0.001 TF:M04075_0 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 0 1 O95394,Q9BY32,Q6YP21,Q53H82 393 4.41e-02 4214 5 4 0.800 0.001 TF:M07261_0 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 0 1 Q9BY32,Q6YP21,Q53H82,Q5T013 393 4.45e-02 8 5 1 0.200 0.125 REAC:446210 rea 1 Synthesis of UDP-N-acetyl-glucosamine 1 O95394 393 4.47e-02 2310 5 3 0.600 0.001 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 Q9BY32,Q6YP21,Q5T013 393 4.47e-02 916 5 2 0.400 0.002 TF:M00790_1 tf 1 Factor: HNF1; motif: WRGTTAATNATTAACNNN; match class: 1 1 Q9BY32,Q53H82 393 4.51e-02 27 5 1 0.200 0.037 KEGG:00630 keg 1 Glyoxylate and dicarboxylate metabolism 1 Q5T013 393 4.53e-02 2323 5 3 0.600 0.001 TF:M00930_0 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 0 1 O95394,Q53H82,Q5T013 393 4.55e-02 10 5 1 0.200 0.100 GO:0016868 MF 1 intramolecular transferase activity, phosphotransferases 1 O95394 393 4.55e-02 10 5 1 0.200 0.100 GO:0042537 BP 1 benzene-containing compound metabolic process 1 Q6YP21 393 4.55e-02 2326 5 3 0.600 0.001 TF:M04169_0 tf 1 Factor: FIGLA; motif: NMCACCTGKN; match class: 0 1 O95394,Q53H82,Q5T013 393 4.62e-02 1985 5 3 0.600 0.002 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q9BY32,Q6YP21,Q5T013 393 4.92e-02 965 5 2 0.400 0.002 TF:M04631_0 tf 1 Factor: RREB; motif: GCACCCMRACY; match class: 0 1 O95394,Q6YP21 393 4.92e-02 4343 5 4 0.800 0.001 TF:M00807_0 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 0 1 O95394,Q6YP21,Q53H82,Q5T013 393 5.00e-02 4 5 1 0.200 0.250 HP:0012393 hp 1 Allergy 1 O95394 393 5.00e-02 406 5 3 0.600 0.007 MI:mmu-miR-468 mi 1 MI:mmu-miR-468 1 O95394,Q6YP21,Q53H82 393 5.00e-02 11 5 1 0.200 0.091 GO:0006048 BP 1 UDP-N-acetylglucosamine biosynthetic process 1 O95394 393 5.00e-02 9 5 1 0.200 0.111 REAC:71240 rea 1 Tryptophan catabolism 1 Q6YP21 393 5.00e-02 30 5 1 0.200 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 Q6YP21 394 9.34e-11 12 7 4 0.571 0.333 GO:0035518 BP 1 histone H2A monoubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 7.30e-10 19 7 4 0.571 0.211 GO:0033522 BP 1 histone H2A ubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 1.67e-09 23 7 4 0.571 0.174 GO:0010390 BP 1 histone monoubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 6.93e-09 8 7 4 0.571 0.500 CORUM:1178 cor 1 BCOR complex 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 1.24e-08 37 7 4 0.571 0.108 GO:0016574 BP 1 histone ubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 2.31e-08 43 7 4 0.571 0.093 GO:0031519 CC 1 PcG protein complex 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 3.06e-08 46 7 4 0.571 0.087 GO:0006513 BP 1 protein monoubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 4.53e-05 281 7 4 0.571 0.014 GO:0016570 BP 1 histone modification 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 5.14e-05 290 7 4 0.571 0.014 GO:0016569 BP 1 covalent chromatin modification 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 1.42e-04 375 7 4 0.571 0.011 GO:0000122 BP 1 negative regulation of transcription from RNA polymerase II promoter 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 2.87e-04 449 7 4 0.571 0.009 GO:0006325 BP 1 chromatin organization 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 3.21e-04 462 7 4 0.571 0.009 GO:0016567 BP 1 protein ubiquitination 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 4.67e-04 3168 7 7 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 394 7.44e-04 573 7 4 0.571 0.007 GO:0032446 BP 1 protein modification by small protein conjugation 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 1.00e-03 619 7 4 0.571 0.006 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.03e-03 623 7 4 0.571 0.006 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.09e-03 632 7 4 0.571 0.006 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.30e-03 662 7 4 0.571 0.006 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 1.34e-03 667 7 4 0.571 0.006 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 2.14e-03 753 7 4 0.571 0.005 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 2.27e-03 765 7 4 0.571 0.005 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 2.42e-03 1 7 1 0.143 1.000 GO:0021678 BP 1 third ventricle development 1 Q8NHM5 394 2.42e-03 1 7 1 0.143 1.000 GO:0021993 BP 1 initiation of neural tube closure 1 Q8NHM5 394 2.42e-03 1 7 1 0.143 1.000 GO:0021592 BP 1 fourth ventricle development 1 Q8NHM5 394 2.42e-03 1 7 1 0.143 1.000 GO:0000415 BP 1 negative regulation of histone H3-K36 methylation 1 Q6W2J9 394 2.42e-03 1 7 1 0.143 1.000 GO:0021555 BP 1 midbrain-hindbrain boundary morphogenesis 1 Q8NHM5 394 2.42e-03 1 7 1 0.143 1.000 GO:0065001 BP 1 specification of axis polarity 1 Q6W2J9 394 2.62e-03 794 7 4 0.571 0.005 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 3.00e-03 822 7 4 0.571 0.005 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 3.17e-03 834 7 4 0.571 0.005 GO:0009890 BP 1 negative regulation of biosynthetic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 3.44e-03 852 7 4 0.571 0.005 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 3.58e-03 861 7 4 0.571 0.005 GO:0010629 BP 1 negative regulation of gene expression 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 3.94e-03 1656 7 5 0.714 0.003 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 4.01e-03 1663 7 5 0.714 0.003 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 4.22e-03 1681 7 5 0.714 0.003 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 4.83e-03 2 7 1 0.143 0.500 GO:0070171 BP 1 negative regulation of tooth mineralization 1 Q6W2J9 394 4.83e-03 2 7 1 0.143 0.500 GO:0051572 BP 1 negative regulation of histone H3-K4 methylation 1 Q6W2J9 394 4.83e-03 2 7 1 0.143 0.500 GO:0042483 BP 1 negative regulation of odontogenesis 1 Q6W2J9 394 4.83e-03 2 7 1 0.143 0.500 GO:0030917 BP 1 midbrain-hindbrain boundary development 1 Q8NHM5 394 4.89e-03 4430 7 7 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 394 5.46e-03 1775 7 5 0.714 0.003 GO:0051252 BP 1 regulation of RNA metabolic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 5.63e-03 970 7 4 0.571 0.004 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 6.89e-03 1865 7 5 0.714 0.003 GO:0006351 BP 1 transcription, DNA-templated 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 7.02e-03 1872 7 5 0.714 0.003 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 7.24e-03 3 7 1 0.143 0.333 GO:0021903 BP 1 rostrocaudal neural tube patterning 1 Q8NHM5 394 7.96e-03 1923 7 5 0.714 0.003 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 8.25e-03 117 7 2 0.286 0.017 GO:0007389 BP 1 pattern specification process 1 Q8NHM5,Q6W2J9 394 9.04e-03 1976 7 5 0.714 0.003 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 9.12e-03 1980 7 5 0.714 0.003 GO:0032774 BP 1 RNA biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 9.43e-03 1994 7 5 0.714 0.003 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 9.65e-03 4 7 1 0.143 0.250 GO:0000414 BP 1 regulation of histone H3-K36 methylation 1 Q6W2J9 394 9.65e-03 4 7 1 0.143 0.250 GO:0070170 BP 1 regulation of tooth mineralization 1 Q6W2J9 394 9.65e-03 4 7 1 0.143 0.250 GO:0021670 BP 1 lateral ventricle development 1 Q8NHM5 394 9.65e-03 4 7 1 0.143 0.250 GO:0002634 BP 1 regulation of germinal center formation 1 P41182 394 9.65e-03 4 7 1 0.143 0.250 GO:0042481 BP 1 regulation of odontogenesis 1 Q6W2J9 394 1.12e-02 2068 7 5 0.714 0.002 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.17e-02 1177 7 4 0.571 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.17e-02 2090 7 5 0.714 0.002 GO:0009889 BP 1 regulation of biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.21e-02 5 7 1 0.143 0.200 GO:2000178 BP 1 negative regulation of neural precursor cell proliferation 1 Q8NHM5 394 1.21e-02 5 7 1 0.143 0.200 GO:0002467 BP 1 germinal center formation 1 P41182 394 1.24e-02 284 7 2 0.286 0.007 MI:hsa-miR-625* mi 1 MI:hsa-miR-625* 1 Q8TE76,Q6W2J9 394 1.36e-02 298 7 2 0.286 0.007 MI:hsa-miR-559 mi 1 MI:hsa-miR-559 1 Q9BSM1,Q6W2J9 394 1.36e-02 151 7 2 0.286 0.013 GO:0003714 MF 1 transcription corepressor activity 1 Q8N488,Q6W2J9 394 1.41e-02 2173 7 5 0.714 0.002 GO:0010468 BP 1 regulation of gene expression 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.45e-02 6 7 1 0.143 0.167 GO:0021532 BP 1 neural tube patterning 1 Q8NHM5 394 1.45e-02 6 7 1 0.143 0.167 GO:0021591 BP 1 ventricular system development 1 Q8NHM5 394 1.45e-02 6 7 1 0.143 0.167 GO:0048596 BP 1 embryonic camera-type eye morphogenesis 1 Q8NHM5 394 1.46e-02 2192 7 5 0.714 0.002 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.59e-02 324 7 2 0.286 0.006 MI:hsa-miR-379* mi 1 MI:hsa-miR-379* 1 Q8NHM5,Q6W2J9 394 1.66e-02 331 7 2 0.286 0.006 MI:hsa-miR-493* mi 1 MI:hsa-miR-493* 1 Q8TE76,Q6W2J9 394 1.69e-02 7 7 1 0.143 0.143 GO:0030502 BP 1 negative regulation of bone mineralization 1 Q6W2J9 394 1.69e-02 7 7 1 0.143 0.143 GO:0002903 BP 1 negative regulation of B cell apoptotic process 1 P41182 394 1.69e-02 7 7 1 0.143 0.143 GO:0031076 BP 1 embryonic camera-type eye development 1 Q8NHM5 394 1.69e-02 7 7 1 0.143 0.143 GO:0034505 BP 1 tooth mineralization 1 Q6W2J9 394 1.71e-02 2267 7 5 0.714 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.74e-02 1310 7 4 0.571 0.003 GO:0031324 BP 1 negative regulation of cellular metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.77e-02 1317 7 4 0.571 0.003 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 1.85e-02 2305 7 5 0.714 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.87e-02 2310 7 5 0.714 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 1.93e-02 8 7 1 0.143 0.125 GO:0010452 BP 1 histone H3-K36 methylation 1 Q6W2J9 394 1.95e-02 361 7 2 0.286 0.006 MI:hsa-miR-374a mi 1 MI:hsa-miR-374a 1 P41182,Q6W2J9 394 2.01e-02 2 7 1 0.143 0.500 CORUM:1508 cor 1 BCL6-ZBTB17 complex 1 P41182 394 2.01e-02 2 7 1 0.143 0.500 CORUM:3 cor 1 BCL6-HDAC7 complex 1 P41182 394 2.01e-02 2 7 1 0.143 0.500 CORUM:2 cor 1 BCL6-HDAC5 complex 1 P41182 394 2.01e-02 2 7 1 0.143 0.500 CORUM:1 cor 1 BCL6-HDAC4 complex 1 P41182 394 2.07e-02 372 7 2 0.286 0.005 MI:hsa-miR-558 mi 1 MI:hsa-miR-558 1 P41182,Q9BSM1 394 2.12e-02 2374 7 5 0.714 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 2.12e-02 634 7 4 0.571 0.006 TF:M03939_0 tf 1 Factor: ZNF740; motif: CCCCCCCCAC; match class: 0 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1 394 2.17e-02 9 7 1 0.143 0.111 GO:0070168 BP 1 negative regulation of biomineral tissue development 1 Q6W2J9 394 2.31e-02 394 7 2 0.286 0.005 MI:mmu-miR-706 mi 1 MI:mmu-miR-706 1 P41182,Q6W2J9 394 2.37e-02 1424 7 4 0.571 0.003 GO:0009892 BP 1 negative regulation of metabolic process 1 Q8NHM5,P41182,Q8N488,Q6W2J9 394 2.41e-02 10 7 1 0.143 0.100 GO:0048048 BP 1 embryonic eye morphogenesis 1 Q8NHM5 394 2.41e-02 10 7 1 0.143 0.100 GO:0002902 BP 1 regulation of B cell apoptotic process 1 P41182 394 2.65e-02 11 7 1 0.143 0.091 GO:0042092 BP 1 type 2 immune response 1 P41182 394 2.65e-02 11 7 1 0.143 0.091 GO:0001783 BP 1 B cell apoptotic process 1 P41182 394 2.65e-02 11 7 1 0.143 0.091 GO:0031061 BP 1 negative regulation of histone methylation 1 Q6W2J9 394 2.83e-02 2529 7 5 0.714 0.002 GO:0005654 CC 1 nucleoplasm 1 Q5H9F3,Q8NHM5,P41182,Q8TE76,Q8N488 394 2.87e-02 443 7 2 0.286 0.005 MI:rno-miR-333 mi 1 MI:rno-miR-333 1 Q8NHM5,Q8TE76 394 2.89e-02 12 7 1 0.143 0.083 GO:0070229 BP 1 negative regulation of lymphocyte apoptotic process 1 P41182 394 2.92e-02 447 7 2 0.286 0.004 MI:hsa-miR-146b-5p mi 1 MI:hsa-miR-146b-5p 1 Q8NHM5,Q6W2J9 394 3.13e-02 464 7 2 0.286 0.004 MI:hsa-miR-146a mi 1 MI:hsa-miR-146a 1 Q8NHM5,Q6W2J9 394 3.18e-02 5787 7 7 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 394 3.18e-02 468 7 2 0.286 0.004 MI:hsa-miR-220 mi 1 MI:hsa-miR-220 1 Q8TE76,Q6W2J9 394 3.26e-02 474 7 2 0.286 0.004 MI:hsa-miR-369-3p mi 1 MI:hsa-miR-369-3p 1 Q8TE76,Q6W2J9 394 3.27e-02 475 7 2 0.286 0.004 MI:hsa-miR-425 mi 1 MI:hsa-miR-425 1 P41182,Q6W2J9 394 3.36e-02 2627 7 5 0.714 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 3.54e-02 5877 7 7 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 394 3.63e-02 502 7 2 0.286 0.004 MI:mmu-miR-703 mi 1 MI:mmu-miR-703 1 Q8NHM5,P41182 394 3.74e-02 1614 7 4 0.571 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q8NHM5,Q9BSM1,Q8N488,Q6W2J9 394 3.85e-02 2707 7 5 0.714 0.002 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 4.02e-02 531 7 2 0.286 0.004 MI:hsa-miR-34c-5p mi 1 MI:hsa-miR-34c-5p 1 Q8NHM5,Q8TE76 394 4.09e-02 17 7 1 0.143 0.059 GO:2000107 BP 1 negative regulation of leukocyte apoptotic process 1 P41182 394 4.09e-02 17 7 1 0.143 0.059 GO:0051569 BP 1 regulation of histone H3-K4 methylation 1 Q6W2J9 394 4.27e-02 2770 7 5 0.714 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 4.87e-02 4214 7 7 1.000 0.002 TF:M07261_0 tf 1 Factor: LKLF; motif: GGGGTGGKSN; match class: 0 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 394 5.00e-02 1 7 1 0.143 1.000 OMIM:300166 omi 1 MICROPHTHALMIA, SYNDROMIC 2; MCOPS2;;OCULOFACIOCARDIODENTAL SYNDROME;;OFCD SYNDROME;;MICROPHTHALMIA, CATARACTS, RADICULOMEGALY, AND SEPTAL HEART DEFECTS;;ANOP2, FORMERLY;;MAA2, FORMERLY 1 Q6W2J9 394 5.00e-02 2 7 1 0.143 0.500 HP:0020006 hp 1 Ciliary body coloboma 1 Q6W2J9 394 5.00e-02 5 7 1 0.143 0.200 CORUM:41 cor 1 Mi-2/NuRD-MTA2 complex 1 P41182 394 5.00e-02 12 7 1 0.143 0.083 REAC:6803205 rea 1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1 P41182 394 5.00e-02 2 7 1 0.143 0.500 HP:0011090 hp 1 Fused teeth 1 Q6W2J9 394 5.00e-02 2869 7 5 0.714 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q8NHM5,P41182,Q9BSM1,Q8N488,Q6W2J9 394 5.00e-02 5 7 1 0.143 0.200 CORUM:585 cor 1 Mi2/NuRD-BCL6-MTA3 complex 1 P41182 394 5.00e-02 2 7 1 0.143 0.500 HP:0011089 hp 1 Double tooth 1 Q6W2J9 394 5.00e-02 2 7 1 0.143 0.500 HP:0007733 hp 1 Laterally curved eyebrow 1 Q6W2J9 394 5.00e-02 4230 7 7 1.000 0.002 TF:M03867_0 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 0 1 Q5H9F3,Q8NHM5,P41182,Q9BSM1,Q8TE76,Q8N488,Q6W2J9 395 2.05e-04 90 2 2 1.000 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P15121,Q9UBQ7 395 2.43e-04 98 2 2 1.000 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 P15121,Q9UBQ7 395 5.90e-04 1 2 1 0.500 1.000 GO:0016618 MF 1 hydroxypyruvate reductase activity 1 Q9UBQ7 395 5.90e-04 1 2 1 0.500 1.000 GO:0030267 MF 1 glyoxylate reductase (NADP) activity 1 Q9UBQ7 395 5.90e-04 1 2 1 0.500 1.000 GO:0043795 MF 1 glyceraldehyde oxidoreductase activity 1 P15121 395 5.90e-04 1 2 1 0.500 1.000 GO:0008465 MF 1 glycerate dehydrogenase activity 1 Q9UBQ7 395 1.18e-03 2 2 1 0.500 0.500 GO:0046370 BP 1 fructose biosynthetic process 1 P15121 395 3.54e-03 6 2 1 0.500 0.167 GO:0004032 MF 1 alditol:NADP+ 1-oxidoreductase activity 1 P15121 395 3.73e-03 778 2 2 1.000 0.003 TF:M07345_1 tf 1 Factor: ZNF515; motif: SCTGCTGK; match class: 1 1 P15121,Q9UBQ7 395 4.17e-03 2 2 1 0.500 0.500 REAC:5652227 rea 1 Fructose biosynthesis 1 P15121 395 4.72e-03 8 2 1 0.500 0.125 GO:0030647 BP 1 aminoglycoside antibiotic metabolic process 1 P15121 395 4.72e-03 8 2 1 0.500 0.125 GO:0044598 BP 1 doxorubicin metabolic process 1 P15121 395 4.72e-03 8 2 1 0.500 0.125 GO:0044597 BP 1 daunorubicin metabolic process 1 P15121 395 4.72e-03 8 2 1 0.500 0.125 GO:0030638 BP 1 polyketide metabolic process 1 P15121 395 5.88e-03 480 2 2 1.000 0.004 GO:0016491 MF 1 oxidoreductase activity 1 P15121,Q9UBQ7 395 5.90e-03 10 2 1 0.500 0.100 GO:0070402 MF 1 NADPH binding 1 Q9UBQ7 395 6.49e-03 11 2 1 0.500 0.091 GO:0006700 BP 1 C21-steroid hormone biosynthetic process 1 P15121 395 6.49e-03 11 2 1 0.500 0.091 GO:0006000 BP 1 fructose metabolic process 1 P15121 395 7.37e-03 47 2 1 0.500 0.021 TF:M05914_0 tf 1 Factor: ZIM3; motif: TTTTACTKTAAG; match class: 0 1 P15121 395 7.67e-03 13 2 1 0.500 0.077 GO:0016137 BP 1 glycoside metabolic process 1 P15121 395 7.67e-03 13 2 1 0.500 0.077 GO:0008106 MF 1 alcohol dehydrogenase (NADP+) activity 1 P15121 395 8.15e-03 52 2 1 0.500 0.019 TF:M05601_0 tf 1 Factor: FIZ1; motif: GGGSTMGGCCT; match class: 0 1 P15121 395 8.85e-03 15 2 1 0.500 0.067 GO:0051287 MF 1 NAD binding 1 Q9UBQ7 395 1.00e-02 17 2 1 0.500 0.059 GO:0008207 BP 1 C21-steroid hormone metabolic process 1 P15121 395 1.09e-02 1332 2 2 1.000 0.002 TF:M04089_0 tf 1 Factor: POU5F1B; motif: ATGMATATKCAW; match class: 0 1 P15121,Q9UBQ7 395 1.15e-02 25 2 1 0.500 0.040 KEGG:00052 keg 1 Galactose metabolism 1 P15121 395 1.15e-02 25 2 1 0.500 0.040 KEGG:00040 keg 1 Pentose and glucuronate interconversions 1 P15121 395 1.18e-02 20 2 1 0.500 0.050 GO:1901661 BP 1 quinone metabolic process 1 P15121 395 1.19e-02 76 2 1 0.500 0.013 TF:M00071_1 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 1 1 Q9UBQ7 395 1.24e-02 27 2 1 0.500 0.037 KEGG:00630 keg 1 Glyoxylate and dicarboxylate metabolism 1 Q9UBQ7 395 1.25e-02 6 2 1 0.500 0.167 REAC:5652084 rea 1 Fructose metabolism 1 P15121 395 1.30e-02 22 2 1 0.500 0.045 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 P15121 395 1.36e-02 23 2 1 0.500 0.043 GO:0007588 BP 1 excretion 1 Q9UBQ7 395 1.47e-02 32 2 1 0.500 0.031 KEGG:00051 keg 1 Fructose and mannose metabolism 1 P15121 395 1.47e-02 25 2 1 0.500 0.040 GO:0050661 MF 1 NADP binding 1 Q9UBQ7 395 1.47e-02 25 2 1 0.500 0.040 GO:0046487 BP 1 glyoxylate metabolic process 1 Q9UBQ7 395 1.51e-02 1565 2 2 1.000 0.001 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 P15121,Q9UBQ7 395 1.53e-02 1576 2 2 1.000 0.001 TF:M00086_1 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 1 1 P15121,Q9UBQ7 395 1.54e-02 1581 2 2 1.000 0.001 TF:M04108_0 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 0 1 P15121,Q9UBQ7 395 1.59e-02 27 2 1 0.500 0.037 GO:0042446 BP 1 hormone biosynthetic process 1 P15121 395 1.67e-02 8 2 1 0.500 0.125 REAC:196108 rea 1 Pregnenolone biosynthesis 1 P15121 395 1.70e-02 37 2 1 0.500 0.027 KEGG:00260 keg 1 Glycine, serine and threonine metabolism 1 Q9UBQ7 395 1.75e-02 38 2 1 0.500 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 Q9UBQ7 395 1.77e-02 30 2 1 0.500 0.033 GO:0019748 BP 1 secondary metabolic process 1 P15121 395 1.93e-02 1767 2 2 1.000 0.001 TF:M00978_0 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 0 1 P15121,Q9UBQ7 395 1.95e-02 33 2 1 0.500 0.030 GO:0005782 CC 1 peroxisomal matrix 1 Q9UBQ7 395 1.95e-02 33 2 1 0.500 0.030 GO:0031907 CC 1 microbody lumen 1 Q9UBQ7 395 2.20e-02 48 2 1 0.500 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 P15121 395 2.27e-02 145 2 1 0.500 0.007 TF:M07264_1 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 1 1 P15121 395 2.35e-02 1953 2 2 1.000 0.001 TF:M00428_1 tf 1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 1 P15121,Q9UBQ7 395 2.39e-02 153 2 1 0.500 0.007 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 Q9UBQ7 395 2.48e-02 42 2 1 0.500 0.024 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P15121 395 2.72e-02 2099 2 2 1.000 0.001 TF:M07376_0 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 0 1 P15121,Q9UBQ7 395 2.75e-02 2111 2 2 1.000 0.001 TF:M04073_1 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1 P15121,Q9UBQ7 395 2.77e-02 47 2 1 0.500 0.021 GO:0034754 BP 1 cellular hormone metabolic process 1 P15121 395 2.82e-02 181 2 1 0.500 0.006 TF:M00420_0 tf 1 Factor: MEIS1A:HOXA9; motif: TGACAGKTTTAYGA; match class: 0 1 Q9UBQ7 395 3.14e-02 2257 2 2 1.000 0.001 TF:M04075_1 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 1 1 P15121,Q9UBQ7 395 3.18e-02 54 2 1 0.500 0.019 GO:0019319 BP 1 hexose biosynthetic process 1 P15121 395 3.42e-02 58 2 1 0.500 0.017 GO:0046364 BP 1 monosaccharide biosynthetic process 1 P15121 395 3.54e-02 17 2 1 0.500 0.059 REAC:196071 rea 1 Metabolism of steroid hormones 1 P15121 395 3.57e-02 2405 2 2 1.000 0.001 TF:M04071_0 tf 1 Factor: POU2F1; motif: NATGMATATKCAWN; match class: 0 1 P15121,Q9UBQ7 395 3.59e-02 61 2 1 0.500 0.016 GO:0044439 CC 1 peroxisomal part 1 Q9UBQ7 395 3.59e-02 61 2 1 0.500 0.016 GO:0044438 CC 1 microbody part 1 Q9UBQ7 395 3.66e-02 235 2 1 0.500 0.004 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 P15121 395 3.67e-02 236 2 1 0.500 0.004 TF:M04427_1 tf 1 Factor: PHOX2B; motif: TAATYYAATTA; match class: 1 1 P15121 395 3.75e-02 241 2 1 0.500 0.004 TF:M04308_1 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 1 1 P15121 395 3.77e-02 242 2 1 0.500 0.004 TF:M01009_1 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 1 1 Q9UBQ7 395 3.89e-02 2511 2 2 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 P15121,Q9UBQ7 395 3.94e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 P15121,Q9UBQ7 395 4.12e-02 265 2 1 0.500 0.004 TF:M04426_1 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 1 1 P15121 395 4.18e-02 71 2 1 0.500 0.014 GO:0006081 BP 1 cellular aldehyde metabolic process 1 Q9UBQ7 395 4.24e-02 72 2 1 0.500 0.014 GO:0009055 MF 1 electron carrier activity 1 P15121 395 4.39e-02 414 2 2 1.000 0.005 MI:hsa-miR-331-5p mi 1 MI:hsa-miR-331-5p 1 P15121,Q9UBQ7 395 4.41e-02 75 2 1 0.500 0.013 GO:0006694 BP 1 steroid biosynthetic process 1 P15121 395 4.54e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P15121,Q9UBQ7 395 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q9UBQ7 395 4.71e-02 80 2 1 0.500 0.013 GO:0042445 BP 1 hormone metabolic process 1 P15121 395 4.73e-02 430 2 2 1.000 0.005 MI:mmu-miR-686 mi 1 MI:mmu-miR-686 1 P15121,Q9UBQ7 395 4.87e-02 2808 2 2 1.000 0.001 TF:M07270_0 tf 1 Factor: TEF-3; motif: GNTATTTTT; match class: 0 1 P15121,Q9UBQ7 395 4.95e-02 319 2 1 0.500 0.003 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q9UBQ7 395 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 P15121,Q9UBQ7 395 5.00e-02 442 2 2 1.000 0.005 MI:hsa-miR-770-5p mi 1 MI:hsa-miR-770-5p 1 P15121,Q9UBQ7 395 5.00e-02 85 2 1 0.500 0.012 GO:0050662 MF 1 coenzyme binding 1 Q9UBQ7 395 5.00e-02 24 2 1 0.500 0.042 REAC:389661 rea 1 Glyoxylate metabolism and glycine degradation 1 Q9UBQ7 395 5.00e-02 4 2 1 0.500 0.250 HP:0008672 hp 1 Calcium oxalate nephrolithiasis 1 Q9UBQ7 395 5.00e-02 1 2 1 0.500 1.000 OMIM:260000 omi 1 HYPEROXALURIA, PRIMARY, TYPE II; HP2;;OXALOSIS II;;GLYCERIC ACIDURIA;;GLYOXYLATE REDUCTASE/HYDROXYPYRUVATE REDUCTASE DEFICIENCY;;D-GLYCERATE DEHYDROGENASE DEFICIENCY 1 Q9UBQ7 396 1.07e-05 27 2 2 1.000 0.074 GO:0048841 BP 1 regulation of axon extension involved in axon guidance 1 Q7Z7M0,Q9UIW2 396 1.15e-05 28 2 2 1.000 0.071 GO:1902667 BP 1 regulation of axon guidance 1 Q7Z7M0,Q9UIW2 396 1.71e-05 34 2 2 1.000 0.059 GO:0048846 BP 1 axon extension involved in axon guidance 1 Q7Z7M0,Q9UIW2 396 1.71e-05 34 2 2 1.000 0.059 GO:1902284 BP 1 neuron projection extension involved in neuron projection guidance 1 Q7Z7M0,Q9UIW2 396 3.02e-05 45 2 2 1.000 0.044 GO:0030516 BP 1 regulation of axon extension 1 Q7Z7M0,Q9UIW2 396 3.30e-05 47 2 2 1.000 0.043 GO:0061387 BP 1 regulation of extent of cell growth 1 Q7Z7M0,Q9UIW2 396 5.59e-05 61 2 2 1.000 0.033 GO:0048675 BP 1 axon extension 1 Q7Z7M0,Q9UIW2 396 7.59e-05 71 2 2 1.000 0.028 GO:0008361 BP 1 regulation of cell size 1 Q7Z7M0,Q9UIW2 396 8.70e-05 76 2 2 1.000 0.026 GO:0050770 BP 1 regulation of axonogenesis 1 Q7Z7M0,Q9UIW2 396 9.90e-05 81 2 2 1.000 0.025 GO:1990138 BP 1 neuron projection extension 1 Q7Z7M0,Q9UIW2 396 1.28e-04 92 2 2 1.000 0.022 GO:0048588 BP 1 developmental cell growth 1 Q7Z7M0,Q9UIW2 396 1.36e-04 95 2 2 1.000 0.021 GO:0050920 BP 1 regulation of chemotaxis 1 Q7Z7M0,Q9UIW2 396 1.45e-04 98 2 2 1.000 0.020 GO:0060560 BP 1 developmental growth involved in morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.76e-04 108 2 2 1.000 0.019 GO:0097485 BP 1 neuron projection guidance 1 Q7Z7M0,Q9UIW2 396 1.76e-04 108 2 2 1.000 0.019 GO:0007411 BP 1 axon guidance 1 Q7Z7M0,Q9UIW2 396 1.83e-04 110 2 2 1.000 0.018 GO:0048638 BP 1 regulation of developmental growth 1 Q7Z7M0,Q9UIW2 396 2.93e-04 139 2 2 1.000 0.014 GO:0010769 BP 1 regulation of cell morphogenesis involved in differentiation 1 Q7Z7M0,Q9UIW2 396 3.52e-04 1 2 1 0.500 1.000 GO:0055113 BP 1 epiboly involved in gastrulation with mouth forming second 1 Q7Z7M0 396 4.28e-04 168 2 2 1.000 0.012 GO:0048589 BP 1 developmental growth 1 Q7Z7M0,Q9UIW2 396 4.70e-04 176 2 2 1.000 0.011 GO:0032535 BP 1 regulation of cellular component size 1 Q7Z7M0,Q9UIW2 396 5.66e-04 193 2 2 1.000 0.010 GO:0010975 BP 1 regulation of neuron projection development 1 Q7Z7M0,Q9UIW2 396 5.78e-04 195 2 2 1.000 0.010 GO:0007409 BP 1 axonogenesis 1 Q7Z7M0,Q9UIW2 396 6.57e-04 208 2 2 1.000 0.010 GO:0061564 BP 1 axon development 1 Q7Z7M0,Q9UIW2 396 7.03e-04 215 2 2 1.000 0.009 GO:0090066 BP 1 regulation of anatomical structure size 1 Q7Z7M0,Q9UIW2 396 7.04e-04 2 2 1 0.500 0.500 GO:0042074 BP 1 cell migration involved in gastrulation 1 Q7Z7M0 396 7.04e-04 2 2 1 0.500 0.500 GO:0060971 BP 1 embryonic heart tube left/right pattern formation 1 Q7Z7M0 396 7.49e-04 222 2 2 1.000 0.009 GO:0001558 BP 1 regulation of cell growth 1 Q7Z7M0,Q9UIW2 396 8.47e-04 236 2 2 1.000 0.008 GO:0045664 BP 1 regulation of neuron differentiation 1 Q7Z7M0,Q9UIW2 396 8.83e-04 241 2 2 1.000 0.008 GO:0048667 BP 1 cell morphogenesis involved in neuron differentiation 1 Q7Z7M0,Q9UIW2 396 9.20e-04 246 2 2 1.000 0.008 GO:0042330 BP 1 taxis 1 Q7Z7M0,Q9UIW2 396 9.20e-04 246 2 2 1.000 0.008 GO:0006935 BP 1 chemotaxis 1 Q7Z7M0,Q9UIW2 396 9.66e-04 252 2 2 1.000 0.008 GO:0022604 BP 1 regulation of cell morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.06e-03 3 2 1 0.500 0.333 GO:0097155 BP 1 fasciculation of sensory neuron axon 1 Q7Z7M0 396 1.06e-03 3 2 1 0.500 0.333 GO:0001702 BP 1 gastrulation with mouth forming second 1 Q7Z7M0 396 1.18e-03 278 2 2 1.000 0.007 GO:0048812 BP 1 neuron projection morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.19e-03 280 2 2 1.000 0.007 GO:0016049 BP 1 cell growth 1 Q7Z7M0,Q9UIW2 396 1.20e-03 281 2 2 1.000 0.007 GO:0050767 BP 1 regulation of neurogenesis 1 Q7Z7M0,Q9UIW2 396 1.21e-03 282 2 2 1.000 0.007 GO:0040008 BP 1 regulation of growth 1 Q7Z7M0,Q9UIW2 396 1.29e-03 291 2 2 1.000 0.007 GO:0048858 BP 1 cell projection morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.36e-03 299 2 2 1.000 0.007 GO:0032990 BP 1 cell part morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.41e-03 304 2 2 1.000 0.007 GO:0031344 BP 1 regulation of cell projection organization 1 Q7Z7M0,Q9UIW2 396 1.41e-03 4 2 1 0.500 0.250 GO:0060972 BP 1 left/right pattern formation 1 Q7Z7M0 396 1.41e-03 4 2 1 0.500 0.250 GO:0097094 BP 1 craniofacial suture morphogenesis 1 Q7Z7M0 396 1.43e-03 306 2 2 1.000 0.007 GO:0051960 BP 1 regulation of nervous system development 1 Q7Z7M0,Q9UIW2 396 1.50e-03 314 2 2 1.000 0.006 GO:0000904 BP 1 cell morphogenesis involved in differentiation 1 Q7Z7M0,Q9UIW2 396 1.74e-03 338 2 2 1.000 0.006 GO:0060284 BP 1 regulation of cell development 1 Q7Z7M0,Q9UIW2 396 1.76e-03 5 2 1 0.500 0.200 GO:0048842 BP 1 positive regulation of axon extension involved in axon guidance 1 Q7Z7M0 396 1.76e-03 5 2 1 0.500 0.200 GO:1902669 BP 1 positive regulation of axon guidance 1 Q7Z7M0 396 1.76e-03 5 2 1 0.500 0.200 GO:0021785 BP 1 branchiomotor neuron axon guidance 1 Q9UIW2 396 1.83e-03 347 2 2 1.000 0.006 GO:0032101 BP 1 regulation of response to external stimulus 1 Q7Z7M0,Q9UIW2 396 2.06e-03 368 2 2 1.000 0.005 GO:0040007 BP 1 growth 1 Q7Z7M0,Q9UIW2 396 2.11e-03 6 2 1 0.500 0.167 GO:0071907 BP 1 determination of digestive tract left/right asymmetry 1 Q7Z7M0 396 2.44e-03 400 2 2 1.000 0.005 GO:0031175 BP 1 neuron projection development 1 Q7Z7M0,Q9UIW2 396 2.47e-03 7 2 1 0.500 0.143 GO:1902287 BP 1 semaphorin-plexin signaling pathway involved in axon guidance 1 Q9UIW2 396 2.92e-03 438 2 2 1.000 0.005 GO:0051270 BP 1 regulation of cellular component movement 1 Q7Z7M0,Q9UIW2 396 2.98e-03 442 2 2 1.000 0.005 GO:0040012 BP 1 regulation of locomotion 1 Q7Z7M0,Q9UIW2 396 2.99e-03 443 2 2 1.000 0.005 GO:0048666 BP 1 neuron development 1 Q7Z7M0,Q9UIW2 396 3.17e-03 9 2 1 0.500 0.111 GO:0017154 MF 1 semaphorin receptor activity 1 Q9UIW2 396 3.17e-03 9 2 1 0.500 0.111 GO:0002116 CC 1 semaphorin receptor complex 1 Q9UIW2 396 3.44e-03 475 2 2 1.000 0.004 GO:0000902 BP 1 cell morphogenesis 1 Q7Z7M0,Q9UIW2 396 3.52e-03 10 2 1 0.500 0.100 GO:1902285 BP 1 semaphorin-plexin signaling pathway involved in neuron projection guidance 1 Q9UIW2 396 3.87e-03 11 2 1 0.500 0.091 GO:0008045 BP 1 motor neuron axon guidance 1 Q9UIW2 396 4.04e-03 515 2 2 1.000 0.004 GO:0032989 BP 1 cellular component morphogenesis 1 Q7Z7M0,Q9UIW2 396 4.17e-03 523 2 2 1.000 0.004 GO:0022603 BP 1 regulation of anatomical structure morphogenesis 1 Q7Z7M0,Q9UIW2 396 4.23e-03 12 2 1 0.500 0.083 GO:0007413 BP 1 axonal fasciculation 1 Q7Z7M0 396 4.40e-03 537 2 2 1.000 0.004 GO:0030182 BP 1 neuron differentiation 1 Q7Z7M0,Q9UIW2 396 5.23e-03 586 2 2 1.000 0.003 GO:0048699 BP 1 generation of neurons 1 Q7Z7M0,Q9UIW2 396 5.28e-03 15 2 1 0.500 0.067 GO:0045773 BP 1 positive regulation of axon extension 1 Q7Z7M0 396 5.63e-03 16 2 1 0.500 0.062 GO:1904888 BP 1 cranial skeletal system development 1 Q7Z7M0 396 5.82e-03 618 2 2 1.000 0.003 GO:0022008 BP 1 neurogenesis 1 Q7Z7M0,Q9UIW2 396 5.98e-03 17 2 1 0.500 0.059 GO:0060349 BP 1 bone morphogenesis 1 Q7Z7M0 396 6.25e-03 640 2 2 1.000 0.003 GO:0016477 BP 1 cell migration 1 Q7Z7M0,Q9UIW2 396 6.44e-03 650 2 2 1.000 0.003 GO:0030030 BP 1 cell projection organization 1 Q7Z7M0,Q9UIW2 396 7.04e-03 20 2 1 0.500 0.050 GO:0090504 BP 1 epiboly 1 Q7Z7M0 396 7.04e-03 20 2 1 0.500 0.050 GO:0048704 BP 1 embryonic skeletal system morphogenesis 1 Q7Z7M0 396 7.39e-03 21 2 1 0.500 0.048 GO:0008038 BP 1 neuron recognition 1 Q7Z7M0 396 7.47e-03 700 2 2 1.000 0.003 GO:0045595 BP 1 regulation of cell differentiation 1 Q7Z7M0,Q9UIW2 396 7.71e-03 711 2 2 1.000 0.003 GO:0048870 BP 1 cell motility 1 Q7Z7M0,Q9UIW2 396 7.71e-03 711 2 2 1.000 0.003 GO:0051674 BP 1 localization of cell 1 Q7Z7M0,Q9UIW2 396 8.80e-03 25 2 1 0.500 0.040 GO:0035113 BP 1 embryonic appendage morphogenesis 1 Q7Z7M0 396 8.80e-03 25 2 1 0.500 0.040 GO:0030326 BP 1 embryonic limb morphogenesis 1 Q7Z7M0 396 8.80e-03 25 2 1 0.500 0.040 GO:0050772 BP 1 positive regulation of axonogenesis 1 Q7Z7M0 396 9.14e-03 774 2 2 1.000 0.003 GO:2000026 BP 1 regulation of multicellular organismal development 1 Q7Z7M0,Q9UIW2 396 9.15e-03 26 2 1 0.500 0.038 GO:0061371 BP 1 determination of heart left/right asymmetry 1 Q7Z7M0 396 9.50e-03 27 2 1 0.500 0.037 GO:0048706 BP 1 embryonic skeletal system development 1 Q7Z7M0 396 9.52e-03 790 2 2 1.000 0.003 GO:0048468 BP 1 cell development 1 Q7Z7M0,Q9UIW2 396 9.55e-03 1244 2 2 1.000 0.002 TF:M00929_0 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 0 1 Q7Z7M0,Q9UIW2 396 9.85e-03 28 2 1 0.500 0.036 GO:0003143 BP 1 embryonic heart tube morphogenesis 1 Q7Z7M0 396 1.01e-02 814 2 2 1.000 0.002 GO:0040011 BP 1 locomotion 1 Q7Z7M0,Q9UIW2 396 1.02e-02 12 2 1 0.500 0.083 REAC:416700 rea 1 Other semaphorin interactions 1 Q9UIW2 396 1.06e-02 30 2 1 0.500 0.033 GO:0035050 BP 1 embryonic heart tube development 1 Q7Z7M0 396 1.06e-02 30 2 1 0.500 0.033 GO:0002011 BP 1 morphogenesis of an epithelial sheet 1 Q7Z7M0 396 1.06e-02 30 2 1 0.500 0.033 GO:0035107 BP 1 appendage morphogenesis 1 Q7Z7M0 396 1.06e-02 30 2 1 0.500 0.033 GO:0035108 BP 1 limb morphogenesis 1 Q7Z7M0 396 1.06e-02 835 2 2 1.000 0.002 GO:0009605 BP 1 response to external stimulus 1 Q7Z7M0,Q9UIW2 396 1.07e-02 1318 2 2 1.000 0.002 TF:M00693_0 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 0 1 Q7Z7M0,Q9UIW2 396 1.10e-02 1333 2 2 1.000 0.002 TF:M07372_0 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 0 1 Q7Z7M0,Q9UIW2 396 1.11e-02 13 2 1 0.500 0.077 REAC:399955 rea 1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1 Q9UIW2 396 1.13e-02 32 2 1 0.500 0.031 GO:0071526 BP 1 semaphorin-plexin signaling pathway 1 Q9UIW2 396 1.16e-02 33 2 1 0.500 0.030 GO:0048565 BP 1 digestive tract development 1 Q7Z7M0 396 1.16e-02 33 2 1 0.500 0.030 GO:0055123 BP 1 digestive system development 1 Q7Z7M0 396 1.31e-02 1460 2 2 1.000 0.001 TF:M00528_0 tf 1 Factor: PPAR; motif: WASNRGGNCAAAGGTCA; match class: 0 1 Q7Z7M0,Q9UIW2 396 1.36e-02 943 2 2 1.000 0.002 GO:0007399 BP 1 nervous system development 1 Q7Z7M0,Q9UIW2 396 1.36e-02 16 2 1 0.500 0.062 REAC:399956 rea 1 CRMPs in Sema3A signaling 1 Q9UIW2 396 1.36e-02 16 2 1 0.500 0.062 REAC:399954 rea 1 Sema3A PAK dependent Axon repulsion 1 Q9UIW2 396 1.41e-02 40 2 1 0.500 0.025 GO:0060173 BP 1 limb development 1 Q7Z7M0 396 1.41e-02 40 2 1 0.500 0.025 GO:0048736 BP 1 appendage development 1 Q7Z7M0 396 1.48e-02 42 2 1 0.500 0.024 GO:0048705 BP 1 skeletal system morphogenesis 1 Q7Z7M0 396 1.48e-02 42 2 1 0.500 0.024 GO:0060348 BP 1 bone development 1 Q7Z7M0 396 1.50e-02 96 2 1 0.500 0.010 TF:M00929_1 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 1 1 Q7Z7M0 396 1.55e-02 1583 2 2 1.000 0.001 TF:M00002_0 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 0 1 Q7Z7M0,Q9UIW2 396 1.57e-02 1016 2 2 1.000 0.002 GO:0006928 BP 1 movement of cell or subcellular component 1 Q7Z7M0,Q9UIW2 396 1.58e-02 45 2 1 0.500 0.022 GO:0007368 BP 1 determination of left/right symmetry 1 Q7Z7M0 396 1.67e-02 107 2 1 0.500 0.009 TF:M03882_1 tf 1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 1 Q9UIW2 396 1.69e-02 48 2 1 0.500 0.021 GO:0009799 BP 1 specification of symmetry 1 Q7Z7M0 396 1.69e-02 48 2 1 0.500 0.021 GO:0009855 BP 1 determination of bilateral symmetry 1 Q7Z7M0 396 1.72e-02 49 2 1 0.500 0.020 GO:0048639 BP 1 positive regulation of developmental growth 1 Q7Z7M0 396 1.74e-02 1067 2 2 1.000 0.002 GO:0050793 BP 1 regulation of developmental process 1 Q7Z7M0,Q9UIW2 396 1.75e-02 1682 2 2 1.000 0.001 TF:M01778_1 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 1 1 Q7Z7M0,Q9UIW2 396 1.87e-02 1107 2 2 1.000 0.002 GO:0009653 BP 1 anatomical structure morphogenesis 1 Q7Z7M0,Q9UIW2 396 1.90e-02 54 2 1 0.500 0.019 GO:0050921 BP 1 positive regulation of chemotaxis 1 Q7Z7M0 396 2.00e-02 1802 2 2 1.000 0.001 TF:M03839_0 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 0 1 Q7Z7M0,Q9UIW2 396 2.07e-02 59 2 1 0.500 0.017 GO:0008037 BP 1 cell recognition 1 Q7Z7M0 396 2.11e-02 60 2 1 0.500 0.017 GO:0010770 BP 1 positive regulation of cell morphogenesis involved in differentiation 1 Q7Z7M0 396 2.38e-02 1966 2 2 1.000 0.001 TF:M07356_0 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 0 1 Q7Z7M0,Q9UIW2 396 2.39e-02 68 2 1 0.500 0.015 GO:0048562 BP 1 embryonic organ morphogenesis 1 Q7Z7M0 396 2.39e-02 68 2 1 0.500 0.015 GO:0030509 BP 1 BMP signaling pathway 1 Q7Z7M0 396 2.43e-02 1263 2 2 1.000 0.002 GO:0051239 BP 1 regulation of multicellular organismal process 1 Q7Z7M0,Q9UIW2 396 2.48e-02 2006 2 2 1.000 0.001 TF:M00360_1 tf 1 Factor: Pax-3; motif: TCGTCACRCTTHM; match class: 1 1 Q7Z7M0,Q9UIW2 396 2.48e-02 159 2 1 0.500 0.006 TF:M07043_1 tf 1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 1 Q7Z7M0 396 2.49e-02 71 2 1 0.500 0.014 GO:0071772 BP 1 response to BMP 1 Q7Z7M0 396 2.49e-02 71 2 1 0.500 0.014 GO:0007369 BP 1 gastrulation 1 Q7Z7M0 396 2.49e-02 71 2 1 0.500 0.014 GO:0071773 BP 1 cellular response to BMP stimulus 1 Q7Z7M0 396 2.56e-02 73 2 1 0.500 0.014 GO:0003002 BP 1 regionalization 1 Q7Z7M0 396 2.67e-02 171 2 1 0.500 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q7Z7M0 396 2.68e-02 172 2 1 0.500 0.006 TF:M07351_1 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 1 1 Q7Z7M0 396 2.74e-02 78 2 1 0.500 0.013 GO:0030307 BP 1 positive regulation of cell growth 1 Q7Z7M0 396 2.74e-02 1340 2 2 1.000 0.001 GO:0032879 BP 1 regulation of localization 1 Q7Z7M0,Q9UIW2 396 2.75e-02 2111 2 2 1.000 0.001 TF:M01009_0 tf 1 Factor: HES-1; motif: ANSBCKYGTGSCNNG; match class: 0 1 Q7Z7M0,Q9UIW2 396 2.93e-02 188 2 1 0.500 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 Q9UIW2 396 3.06e-02 1416 2 2 1.000 0.001 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q7Z7M0,Q9UIW2 396 3.16e-02 1438 2 2 1.000 0.001 GO:0051128 BP 1 regulation of cellular component organization 1 Q7Z7M0,Q9UIW2 396 3.16e-02 90 2 1 0.500 0.011 GO:0003007 BP 1 heart morphogenesis 1 Q7Z7M0 396 3.33e-02 2 2 1 0.500 0.500 CORUM:5757 cor 1 PLXNA1-RANBPM complex 1 Q9UIW2 396 3.33e-02 2 2 1 0.500 0.500 CORUM:5745 cor 1 PlexinA1-NRP1 complex 1 Q9UIW2 396 3.34e-02 2328 2 2 1.000 0.001 TF:M03834_0 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 0 1 Q7Z7M0,Q9UIW2 396 3.47e-02 99 2 1 0.500 0.010 GO:0010976 BP 1 positive regulation of neuron projection development 1 Q7Z7M0 396 3.47e-02 99 2 1 0.500 0.010 GO:0060562 BP 1 epithelial tube morphogenesis 1 Q7Z7M0 396 3.54e-02 101 2 1 0.500 0.010 GO:0045927 BP 1 positive regulation of growth 1 Q7Z7M0 396 3.54e-02 101 2 1 0.500 0.010 GO:0048568 BP 1 embryonic organ development 1 Q7Z7M0 396 3.54e-02 1524 2 2 1.000 0.001 GO:0030154 BP 1 cell differentiation 1 Q7Z7M0,Q9UIW2 396 3.68e-02 105 2 1 0.500 0.010 GO:0032103 BP 1 positive regulation of response to external stimulus 1 Q7Z7M0 396 3.77e-02 2472 2 2 1.000 0.001 TF:M03557_1 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 1 Q7Z7M0,Q9UIW2 396 3.82e-02 109 2 1 0.500 0.009 GO:0009792 BP 1 embryo development ending in birth or egg hatching 1 Q7Z7M0 396 3.82e-02 109 2 1 0.500 0.009 GO:0035239 BP 1 tube morphogenesis 1 Q7Z7M0 396 3.82e-02 109 2 1 0.500 0.009 GO:0043009 BP 1 chordate embryonic development 1 Q7Z7M0 396 4.10e-02 117 2 1 0.500 0.009 GO:0007389 BP 1 pattern specification process 1 Q7Z7M0 396 4.14e-02 266 2 1 0.500 0.004 TF:M07356_1 tf 1 Factor: HIF2A; motif: ACGTGNNN; match class: 1 1 Q7Z7M0 396 4.15e-02 1649 2 2 1.000 0.001 GO:0048869 BP 1 cellular developmental process 1 Q7Z7M0,Q9UIW2 396 4.24e-02 121 2 1 0.500 0.008 GO:0045666 BP 1 positive regulation of neuron differentiation 1 Q7Z7M0 396 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 Q7Z7M0 396 4.47e-02 288 2 1 0.500 0.003 TF:M01209_1 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 1 1 Q7Z7M0 396 4.67e-02 301 2 1 0.500 0.003 TF:M04134_1 tf 1 Factor: TBX2; motif: NAGGTGTGAAN; match class: 1 1 Q7Z7M0 396 4.98e-02 321 2 1 0.500 0.003 TF:M07117_0 tf 1 Factor: TR4; motif: NGRGGTCARAGGTCA; match class: 0 1 Q7Z7M0 396 5.00e-02 59 2 1 0.500 0.017 REAC:373755 rea 1 Semaphorin interactions 1 Q9UIW2 396 5.00e-02 1810 2 2 1.000 0.001 GO:0048731 BP 1 system development 1 Q7Z7M0,Q9UIW2 396 5.00e-02 2 2 1 0.500 0.500 HP:0010093 hp 1 Duplication of the proximal phalanx of the hallux 1 Q7Z7M0 396 5.00e-02 3 2 1 0.500 0.333 CORUM:5646 cor 1 FARP2-NRP1-PlexinA1 complex 1 Q9UIW2 396 5.00e-02 2 2 1 0.500 0.500 HP:0009613 hp 1 Duplication of the proximal phalanx of the thumb 1 Q7Z7M0 396 5.00e-02 2 2 1 0.500 0.500 HP:0010275 hp 1 Pseudoepiphyses of the proximal phalanges of the hand 1 Q7Z7M0 396 5.00e-02 1 2 1 0.500 1.000 OMIM:614976 omi 1 CARPENTER SYNDROME 2; CRPT2 1 Q7Z7M0 396 5.00e-02 3 2 1 0.500 0.333 CORUM:5746 cor 1 PlexinA1-NRP1-SEMA3A complex 1 Q9UIW2 396 5.00e-02 2 2 1 0.500 0.500 HP:0010202 hp 1 Duplication of middle phalanx of toe 1 Q7Z7M0 396 5.00e-02 2 2 1 0.500 0.500 HP:0006397 hp 1 Lateral displacement of patellae 1 Q7Z7M0 396 5.00e-02 2 2 1 0.500 0.500 HP:0010008 hp 1 Duplication of the middle phalanx of hand 1 Q7Z7M0 396 5.00e-02 3 2 1 0.500 0.333 CORUM:5762 cor 1 CRMP-MICAL-PlexinA1 complex, induced by SEMA3A 1 Q9UIW2 396 5.00e-02 3 2 1 0.500 0.333 CORUM:5689 cor 1 SEMA6D-PlexinA1-NRP1 complex 1 Q9UIW2 396 5.00e-02 2 2 1 0.500 0.500 HP:0009608 hp 1 Complete duplication of proximal phalanx of the thumb 1 Q7Z7M0 396 5.00e-02 2 2 1 0.500 0.500 HP:0010002 hp 1 Complete duplication of the middle phalanges of the hand 1 Q7Z7M0 397 2.53e-14 20 11 6 0.545 0.300 GO:0030904 CC 1 retromer complex 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 7.62e-14 222 11 9 0.818 0.041 GO:0016197 BP 1 endosomal transport 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q9Y4E1 397 8.09e-14 120 11 8 0.727 0.067 GO:0016482 BP 1 cytosolic transport 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 2.71e-13 68 11 7 0.636 0.103 GO:0042147 BP 1 retrograde transport, endosome to Golgi 1 Q96QK1,Q641Q2,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 5.20e-13 466 11 10 0.909 0.021 GO:0005768 CC 1 endosome 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 1.62e-12 13 11 5 0.455 0.385 GO:1990126 BP 1 retrograde transport, endosome to plasma membrane 1 Q96QK1,Q96NW4,Q9UBQ0,O75436,Q9Y4E1 397 2.08e-12 4 11 4 0.364 1.000 GO:0030906 CC 1 retromer, cargo-selective complex 1 Q96QK1,Q9UBQ0,O75436,Q4G0F5 397 1.58e-10 165 11 7 0.636 0.042 GO:0005769 CC 1 early endosome 1 Q96QK1,Q641Q2,Q96NW4,O75436,Q4G0F5,Q12768,Q9Y4E1 397 2.61e-10 9 11 4 0.364 0.444 GO:0071203 CC 1 WASH complex 1 Q641Q2,Q2M389,Q12768,Q9Y4E1 397 4.24e-10 910 11 10 0.909 0.011 GO:0097708 CC 1 intracellular vesicle 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 5.32e-10 931 11 10 0.909 0.011 GO:0031410 CC 1 cytoplasmic vesicle 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 1.10e-08 66 11 5 0.455 0.076 GO:0098876 BP 1 vesicle-mediated transport to the plasma membrane 1 Q96QK1,Q96NW4,Q9UBQ0,O75436,Q9Y4E1 397 2.99e-08 5 11 3 0.273 0.600 GO:0097422 CC 1 tubular endosome 1 Q96QK1,Q96NW4,O75436 397 1.34e-06 958 11 8 0.727 0.008 GO:0016192 BP 1 vesicle-mediated transport 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 1.55e-06 67 11 4 0.364 0.060 GO:0008565 MF 1 protein transporter activity 1 Q96QK1,Q9UBQ0,O75436,Q4G0F5 397 3.45e-06 2260 11 10 0.909 0.004 GO:0012505 CC 1 endomembrane system 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 5.73e-06 444 11 6 0.545 0.014 GO:0098796 CC 1 membrane protein complex 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 9.75e-06 1237 11 8 0.727 0.006 GO:0046907 BP 1 intracellular transport 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 1.99e-05 18 11 3 0.273 0.167 REAC:3238698 rea 1 WNT ligand biogenesis and trafficking 1 Q96QK1,Q9UBQ0,O75436 397 2.30e-05 4 11 2 0.182 0.500 GO:1905394 MF 1 retromer complex binding 1 Q92609,Q9Y4E1 397 2.75e-05 2795 11 10 0.909 0.004 GO:0031982 CC 1 vesicle 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 3.81e-05 2096 11 9 0.818 0.004 GO:0043234 CC 1 protein complex 1 Q96QK1,Q641Q2,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 4.13e-05 1493 11 8 0.727 0.005 GO:0051649 BP 1 establishment of localization in cell 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 1.40e-04 207 11 4 0.364 0.019 GO:0010506 BP 1 regulation of autophagy 1 Q96QK1,O75436,Q92609,Q4G0F5 397 1.98e-04 1836 11 8 0.727 0.004 GO:0051641 BP 1 cellular localization 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q4G0F5,Q9Y4E1 397 2.01e-04 227 11 4 0.364 0.018 GO:0044440 CC 1 endosomal part 1 Q96QK1,Q96NW4,O75436,Q92609 397 2.79e-04 2644 11 9 0.818 0.003 GO:0006810 BP 1 transport 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q9Y4E1 397 3.87e-04 2748 11 9 0.818 0.003 GO:0051234 BP 1 establishment of localization 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q9Y4E1 397 4.47e-04 99 11 3 0.273 0.030 GO:0016241 BP 1 regulation of macroautophagy 1 Q96QK1,O75436,Q4G0F5 397 6.98e-04 115 11 3 0.273 0.026 GO:0005770 CC 1 late endosome 1 Q96QK1,Q96NW4,Q4G0F5 397 7.92e-04 4 11 2 0.182 0.500 TF:M05818_0 tf 1 Factor: ZNF627; motif: GAAWCGAGCACA; match class: 0 1 Q641Q2,Q9Y4E1 397 9.65e-04 340 11 4 0.364 0.012 GO:0006914 BP 1 autophagy 1 Q96QK1,O75436,Q92609,Q4G0F5 397 9.79e-04 41 11 3 0.273 0.073 TF:M05350_0 tf 1 Factor: OZF; motif: KGTTAAAGGARA; match class: 0 1 Q641Q2,Q96NW4,Q9Y4E1 397 1.26e-03 651 11 6 0.545 0.009 TF:M03789_0 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 0 1 Q641Q2,Q96NW4,O75436,Q92609,Q2M389,Q9Y4E1 397 1.36e-03 709 11 5 0.455 0.007 GO:0006886 BP 1 intracellular protein transport 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 2.31e-03 3401 11 9 0.818 0.003 GO:0051179 BP 1 localization 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q9Y4E1 397 2.39e-03 3415 11 9 0.818 0.003 GO:0032991 CC 1 macromolecular complex 1 Q96QK1,Q641Q2,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 2.43e-03 3113 11 10 0.909 0.003 HPA:039030_02 hpa 1 soft tissue 1; fibroblasts[Uncertain,Medium] 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,Q5T1M5,O75436,Q92609,Q2M389,Q12768,Q9Y4E1 397 3.50e-03 199 11 3 0.273 0.015 GO:0010008 CC 1 endosome membrane 1 Q96QK1,O75436,Q92609 397 3.71e-03 203 11 3 0.273 0.015 GO:0016236 BP 1 macroautophagy 1 Q96QK1,O75436,Q4G0F5 397 3.72e-03 45 11 2 0.182 0.044 GO:0031338 BP 1 regulation of vesicle fusion 1 Q96NW4,Q92609 397 4.16e-03 499 11 4 0.364 0.008 GO:0044433 CC 1 cytoplasmic vesicle part 1 Q96QK1,Q96NW4,O75436,Q92609 397 4.43e-03 1 11 1 0.091 1.000 GO:0099639 BP 1 neurotransmitter receptor transport, endosome to plasma membrane 1 Q96QK1 397 4.43e-03 1 11 1 0.091 1.000 GO:2000331 BP 1 regulation of terminal button organization 1 Q96QK1 397 4.43e-03 1 11 1 0.091 1.000 GO:0035544 BP 1 negative regulation of SNARE complex assembly 1 Q96NW4 397 4.43e-03 1 11 1 0.091 1.000 GO:0098877 BP 1 neurotransmitter receptor transport to plasma membrane 1 Q96QK1 397 4.43e-03 1 11 1 0.091 1.000 GO:0031339 BP 1 negative regulation of vesicle fusion 1 Q96NW4 397 4.43e-03 1 11 1 0.091 1.000 GO:0099638 BP 1 endosome to plasma membrane protein transport 1 Q96QK1 397 5.03e-03 3 11 3 0.273 1.000 CORUM:656 cor 1 VPS35-VPS29-VPS26A complex 1 Q96QK1,Q9UBQ0,O75436 397 5.19e-03 1830 11 8 0.727 0.004 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 Q641Q2,Q9UBQ0,Q5T1M5,O75436,Q92609,Q2M389,Q12768,Q9Y4E1 397 5.64e-03 1 11 1 0.091 1.000 OMIM:603563 omi 1 SPASTIC PARAPLEGIA 8, AUTOSOMAL DOMINANT; SPG8 1 Q12768 397 5.64e-03 1 11 1 0.091 1.000 OMIM:614203 omi 1 PARKINSON DISEASE 17; PARK17 1 Q96QK1 397 5.64e-03 1 11 1 0.091 1.000 OMIM:615817 omi 1 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 43; MRT43 1 Q2M389 397 5.65e-03 964 11 5 0.455 0.005 GO:0015031 BP 1 protein transport 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 5.69e-03 392 11 3 0.273 0.008 MI:hsa-miR-652 mi 1 MI:hsa-miR-652 1 Q641Q2,Q2M389,Q9Y4E1 397 6.38e-03 59 11 2 0.182 0.034 GO:0031333 BP 1 negative regulation of protein complex assembly 1 Q96NW4,Q9Y4E1 397 8.05e-03 444 11 3 0.273 0.007 MI:hsa-miR-507 mi 1 MI:hsa-miR-507 1 Q641Q2,Q5T1M5,Q9Y4E1 397 8.86e-03 2 11 1 0.091 0.500 GO:1902950 BP 1 regulation of dendritic spine maintenance 1 Q96QK1 397 8.86e-03 2 11 1 0.091 0.500 GO:0099074 BP 1 mitochondrion to lysosome transport 1 Q96QK1 397 8.86e-03 2 11 1 0.091 0.500 GO:1903336 BP 1 negative regulation of vacuolar transport 1 Q96QK1 397 8.86e-03 2 11 1 0.091 0.500 GO:0099075 BP 1 mitochondrion-derived vesicle mediated transport 1 Q96QK1 397 8.86e-03 2 11 1 0.091 0.500 GO:0099637 BP 1 neurotransmitter receptor transport 1 Q96QK1 397 8.86e-03 2 11 1 0.091 0.500 GO:1902823 BP 1 negative regulation of late endosome to lysosome transport 1 Q96QK1 397 9.48e-03 281 11 3 0.273 0.011 GO:0016050 BP 1 vesicle organization 1 Q96NW4,Q92609,Q2M389 397 9.53e-03 1985 11 8 0.727 0.004 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,Q5T1M5,O75436,Q2M389,Q9Y4E1 397 1.03e-02 1100 11 5 0.455 0.005 GO:0045184 BP 1 establishment of protein localization 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 1.07e-02 1111 11 5 0.455 0.005 GO:0034613 BP 1 cellular protein localization 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 1.11e-02 499 11 3 0.273 0.006 MI:hsa-miR-499-5p mi 1 MI:hsa-miR-499-5p 1 Q641Q2,O75436,Q9Y4E1 397 1.12e-02 1121 11 5 0.455 0.004 GO:0070727 BP 1 cellular macromolecule localization 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 1.13e-02 2 11 1 0.091 0.500 OMIM:220210 omi 1 Ritscher-Schinzel Syndrome 1 Q12768 397 1.15e-02 301 11 3 0.273 0.010 GO:0016055 BP 1 Wnt signaling pathway 1 Q96QK1,Q9UBQ0,O75436 397 1.15e-02 301 11 3 0.273 0.010 GO:0198738 BP 1 cell-cell signaling by wnt 1 Q96QK1,Q9UBQ0,O75436 397 1.17e-02 658 11 4 0.364 0.006 GO:0022892 MF 1 substrate-specific transporter activity 1 Q96QK1,Q9UBQ0,O75436,Q4G0F5 397 1.33e-02 3 11 1 0.091 0.333 GO:0099073 CC 1 mitochondrion-derived vesicle 1 Q96QK1 397 1.33e-02 3 11 1 0.091 0.333 GO:0031748 MF 1 D1 dopamine receptor binding 1 Q96QK1 397 1.33e-02 3 11 1 0.091 0.333 GO:1902822 BP 1 regulation of late endosome to lysosome transport 1 Q96QK1 397 1.33e-02 3 11 1 0.091 0.333 GO:1903335 BP 1 regulation of vacuolar transport 1 Q96QK1 397 1.33e-02 3 11 1 0.091 0.333 GO:2000813 BP 1 negative regulation of barbed-end actin filament capping 1 Q9Y4E1 397 1.33e-02 3 11 1 0.091 0.333 GO:0072553 BP 1 terminal button organization 1 Q96QK1 397 1.41e-02 323 11 3 0.273 0.009 GO:1905114 BP 1 cell surface receptor signaling pathway involved in cell-cell signaling 1 Q96QK1,Q9UBQ0,O75436 397 1.44e-02 4954 11 11 1.000 0.002 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,Q5T1M5,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 1.50e-02 91 11 2 0.182 0.022 GO:0017137 MF 1 Rab GTPase binding 1 Q96NW4,Q92609 397 1.52e-02 707 11 4 0.364 0.006 GO:0033043 BP 1 regulation of organelle organization 1 Q96QK1,Q96NW4,Q92609,Q9Y4E1 397 1.54e-02 563 11 3 0.273 0.005 MI:hsa-miR-520a-5p mi 1 MI:hsa-miR-520a-5p 1 Q96QK1,Q4G0F5,Q9Y4E1 397 1.77e-02 4 11 1 0.091 0.250 GO:0060161 BP 1 positive regulation of dopamine receptor signaling pathway 1 Q96QK1 397 1.77e-02 4 11 1 0.091 0.250 GO:2000812 BP 1 regulation of barbed-end actin filament capping 1 Q9Y4E1 397 1.77e-02 4 11 1 0.091 0.250 GO:0097062 BP 1 dendritic spine maintenance 1 Q96QK1 397 1.88e-02 750 11 4 0.364 0.005 GO:0005215 MF 1 transporter activity 1 Q96QK1,Q9UBQ0,O75436,Q4G0F5 397 2.10e-02 108 11 2 0.182 0.019 GO:0006906 BP 1 vesicle fusion 1 Q96NW4,Q92609 397 2.11e-02 3899 11 10 0.909 0.003 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,Q5T1M5,O75436,Q92609,Q2M389,Q12768,Q9Y4E1 397 2.14e-02 109 11 2 0.182 0.018 GO:0090174 BP 1 organelle membrane fusion 1 Q96NW4,Q92609 397 2.17e-02 5629 11 10 0.909 0.002 GO:0044444 CC 1 cytoplasmic part 1 Q96QK1,Q641Q2,Q96NW4,Q9UBQ0,O75436,Q92609,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 2.21e-02 5 11 1 0.091 0.200 GO:1902774 BP 1 late endosome to lysosome transport 1 Q96QK1 397 2.21e-02 5 11 1 0.091 0.200 GO:0050780 MF 1 dopamine receptor binding 1 Q96QK1 397 2.21e-02 5 11 1 0.091 0.200 GO:0045056 BP 1 transcytosis 1 Q96QK1 397 2.21e-02 5 11 1 0.091 0.200 GO:1990316 CC 1 ATG1/ULK1 kinase complex 1 Q92609 397 2.47e-02 394 11 3 0.273 0.008 GO:0005773 CC 1 vacuole 1 Q96QK1,Q96NW4,Q92609 397 2.78e-02 1377 11 5 0.455 0.004 GO:0071702 BP 1 organic substance transport 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 2.92e-02 1393 11 5 0.455 0.004 GO:0008104 BP 1 protein localization 1 Q96QK1,Q9UBQ0,O75436,Q92609,Q4G0F5 397 3.09e-02 7 11 1 0.091 0.143 GO:0035542 BP 1 regulation of SNARE complex assembly 1 Q96NW4 397 3.09e-02 7 11 1 0.091 0.143 GO:0035612 MF 1 AP-2 adaptor complex binding 1 Q92609 397 3.09e-02 7 11 1 0.091 0.143 GO:0010314 MF 1 phosphatidylinositol-5-phosphate binding 1 Q9Y4E1 397 3.10e-02 132 11 2 0.182 0.015 GO:0044801 BP 1 single-organism membrane fusion 1 Q96NW4,Q92609 397 3.27e-02 296 11 2 0.182 0.007 MI:hsa-miR-194* mi 1 MI:hsa-miR-194* 1 Q641Q2,Q9Y4E1 397 3.39e-02 302 11 2 0.182 0.007 MI:hsa-miR-551b* mi 1 MI:hsa-miR-551b* 1 Q641Q2,Q9Y4E1 397 3.53e-02 8 11 1 0.091 0.125 GO:0060159 BP 1 regulation of dopamine receptor signaling pathway 1 Q96QK1 397 3.53e-02 8 11 1 0.091 0.125 GO:0043653 BP 1 mitochondrial fragmentation involved in apoptotic process 1 Q96QK1 397 3.77e-02 146 11 2 0.182 0.014 GO:0048284 BP 1 organelle fusion 1 Q96NW4,Q92609 397 3.84e-02 323 11 2 0.182 0.006 MI:hsa-miR-143* mi 1 MI:hsa-miR-143* 1 Q2M389,Q9Y4E1 397 3.97e-02 9 11 1 0.091 0.111 GO:0035493 BP 1 SNARE complex assembly 1 Q96NW4 397 3.97e-02 9 11 1 0.091 0.111 GO:0030836 BP 1 positive regulation of actin filament depolymerization 1 Q9Y4E1 397 4.04e-02 332 11 2 0.182 0.006 MI:hsa-miR-545* mi 1 MI:hsa-miR-545* 1 Q641Q2,Q9Y4E1 397 4.34e-02 157 11 2 0.182 0.013 GO:0061025 BP 1 membrane fusion 1 Q96NW4,Q92609 397 4.40e-02 348 11 2 0.182 0.006 MI:hsa-miR-518f* mi 1 MI:hsa-miR-518f* 1 Q641Q2,Q9Y4E1 397 4.41e-02 10 11 1 0.091 0.100 GO:0030122 CC 1 AP-2 adaptor complex 1 Q92609 397 4.41e-02 10 11 1 0.091 0.100 GO:0030128 CC 1 clathrin coat of endocytic vesicle 1 Q92609 397 4.68e-02 360 11 2 0.182 0.006 MI:hsa-miR-302c* mi 1 MI:hsa-miR-302c* 1 Q641Q2,Q9Y4E1 397 4.80e-02 365 11 2 0.182 0.005 MI:hsa-miR-518e* mi 1 MI:hsa-miR-518e* 1 Q641Q2,Q9Y4E1 397 4.85e-02 11 11 1 0.091 0.091 GO:0030132 CC 1 clathrin coat of coated pit 1 Q92609 397 4.89e-02 504 11 3 0.273 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q96NW4,Q92609,Q9Y4E1 397 5.00e-02 247 11 3 0.273 0.012 REAC:195721 rea 1 Signaling by Wnt 1 Q96QK1,Q9UBQ0,O75436 397 5.00e-02 152 11 3 0.273 0.020 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q641Q2,O75436,Q9Y4E1 397 5.00e-02 9 11 1 0.091 0.111 OMIM:182600 omi 1 Autosomal Dominant Spastic Paraplegia 1 Q12768 397 5.00e-02 5 11 3 0.273 0.600 CORUM:657 cor 1 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) 1 Q96QK1,Q9UBQ0,O75436 397 5.00e-02 229 11 8 0.727 0.035 KEGG:04144 keg 1 Endocytosis 1 Q96QK1,Q641Q2,Q9UBQ0,O75436,Q2M389,Q4G0F5,Q12768,Q9Y4E1 397 5.00e-02 152 11 3 0.273 0.020 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q641Q2,O75436,Q9Y4E1 397 5.00e-02 3292 11 9 0.818 0.003 HPA:016010_03 hpa 1 gallbladder; glandular cells[Uncertain,High] 1 Q96QK1,Q641Q2,Q9UBQ0,Q5T1M5,O75436,Q92609,Q2M389,Q4G0F5,Q9Y4E1 397 5.00e-02 152 11 3 0.273 0.020 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q641Q2,O75436,Q9Y4E1 397 5.00e-02 5 11 3 0.273 0.600 CORUM:1060 cor 1 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) 1 Q96QK1,Q9UBQ0,Q4G0F5 397 5.00e-02 14 11 2 0.182 0.143 HP:0011008 hp 1 Temporal pattern 1 Q96QK1,Q12768 397 5.00e-02 14 11 2 0.182 0.143 HP:0003587 hp 1 Insidious onset 1 Q96QK1,Q12768 397 5.00e-02 169 11 2 0.182 0.012 GO:0017016 MF 1 Ras GTPase binding 1 Q96NW4,Q92609 397 5.00e-02 5 11 3 0.273 0.600 CORUM:1059 cor 1 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) 1 Q96QK1,Q9UBQ0,O75436 397 5.00e-02 152 11 3 0.273 0.020 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q641Q2,O75436,Q9Y4E1 398 1.25e-02 6 2 1 0.500 0.167 GO:0036310 MF 1 annealing helicase activity 1 Q9NZC9 398 2.08e-02 10 2 1 0.500 0.100 GO:0097617 MF 1 annealing activity 1 Q9NZC9 398 3.13e-02 15 2 1 0.500 0.067 GO:0005662 CC 1 DNA replication factor A complex 1 Q9NZC9 398 3.54e-02 17 2 1 0.500 0.059 GO:0002244 BP 1 hematopoietic progenitor cell differentiation 1 Q6NXE6 398 5.00e-02 1 2 1 0.500 1.000 OMIM:242900 omi 1 IMMUNOOSSEOUS DYSPLASIA, SCHIMKE TYPE;;SCHIMKE IMMUNOOSSEOUS DYSPLASIA; SIOD 1 Q9NZC9 398 5.00e-02 2 2 1 0.500 0.500 TF:M05743_0 tf 1 Factor: ZNF57; motif: NGYTAGGGCAGA; match class: 0 1 Q6NXE6 398 5.00e-02 24 2 1 0.500 0.042 GO:0031297 BP 1 replication fork processing 1 Q9NZC9 398 5.00e-02 1 2 1 0.500 1.000 HP:0006453 hp 1 Lateral displacement of the femoral head 1 Q9NZC9 399 4.83e-10 22 6 4 0.667 0.182 GO:0046540 CC 1 U4/U6 x U5 tri-snRNP complex 1 Q96NC0,P62312,P62310,Q9Y333 399 4.96e-10 269 6 6 1.000 0.022 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.16e-09 27 6 4 0.667 0.148 GO:0097526 CC 1 spliceosomal tri-snRNP complex 1 Q96NC0,P62312,P62310,Q9Y333 399 1.59e-09 326 6 6 1.000 0.018 GO:0008380 BP 1 RNA splicing 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 8.91e-09 7 6 3 0.500 0.429 GO:0005688 CC 1 U6 snRNP 1 P62312,P62310,Q9Y333 399 2.08e-08 54 6 4 0.667 0.074 GO:0097525 CC 1 spliceosomal snRNP complex 1 Q96NC0,P62312,P62310,Q9Y333 399 3.43e-08 61 6 4 0.667 0.066 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 Q96NC0,P62312,P62310,Q9Y333 399 5.25e-08 173 6 5 0.833 0.029 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P41223,O75940,P62312,P62310,Q9Y333 399 6.41e-08 180 6 5 0.833 0.028 REAC:72172 rea 1 mRNA Splicing 1 P41223,O75940,P62312,P62310,Q9Y333 399 1.18e-07 265 6 5 0.833 0.019 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 1.18e-07 265 6 5 0.833 0.019 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 1.73e-07 15 6 3 0.500 0.200 REAC:430039 rea 1 mRNA decay by 5' to 3' exoribonuclease 1 P62312,P62310,Q9Y333 399 2.10e-07 228 6 5 0.833 0.022 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P41223,O75940,P62312,P62310,Q9Y333 399 2.27e-07 128 6 6 1.000 0.047 KEGG:03040 keg 1 Spliceosome 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 2.45e-07 752 6 6 1.000 0.008 GO:0006396 BP 1 RNA processing 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 4.19e-07 7 6 3 0.500 0.429 CORUM:561 cor 1 LSm1-7 complex 1 P62312,P62310,Q9Y333 399 4.19e-07 7 6 3 0.500 0.429 CORUM:562 cor 1 LSm2-8 complex 1 P62312,P62310,Q9Y333 399 4.25e-07 342 6 5 0.833 0.015 GO:0006397 BP 1 mRNA processing 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 9.26e-07 29 6 3 0.500 0.103 GO:0043928 BP 1 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 1 P62312,P62310,Q9Y333 399 1.14e-06 31 6 3 0.500 0.097 GO:0000291 BP 1 nuclear-transcribed mRNA catabolic process, exonucleolytic 1 P62312,P62310,Q9Y333 399 3.51e-06 522 6 5 0.833 0.010 GO:0016071 BP 1 mRNA metabolic process 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 4.40e-06 4 6 2 0.333 0.500 GO:1990726 CC 1 Lsm1-7-Pat1 complex 1 P62310,Q9Y333 399 5.58e-06 52 6 3 0.500 0.058 GO:0000932 CC 1 P-body 1 P62312,P62310,Q9Y333 399 5.62e-06 141 6 5 0.833 0.035 CORUM:351 cor 1 Spliceosome 1 P41223,O75940,P62312,P62310,Q9Y333 399 6.95e-06 599 6 5 0.833 0.008 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 7.01e-06 600 6 5 0.833 0.008 GO:1990904 CC 1 ribonucleoprotein complex 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 9.06e-06 61 6 3 0.500 0.049 GO:0000288 BP 1 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 P62312,P62310,Q9Y333 399 9.33e-06 54 6 3 0.500 0.056 REAC:429914 rea 1 Deadenylation-dependent mRNA decay 1 P62312,P62310,Q9Y333 399 5.99e-05 114 6 3 0.500 0.026 GO:0036464 CC 1 cytoplasmic ribonucleoprotein granule 1 P62312,P62310,Q9Y333 399 6.99e-05 120 6 3 0.500 0.025 GO:0035770 CC 1 ribonucleoprotein granule 1 P62312,P62310,Q9Y333 399 1.28e-04 147 6 3 0.500 0.020 GO:0005681 CC 1 spliceosomal complex 1 P41223,P62310,Q9Y333 399 2.19e-04 25 6 2 0.333 0.080 GO:0071011 CC 1 precatalytic spliceosome 1 P62310,Q9Y333 399 2.68e-04 188 6 3 0.500 0.016 GO:0000956 BP 1 nuclear-transcribed mRNA catabolic process 1 P62312,P62310,Q9Y333 399 3.17e-04 199 6 3 0.500 0.015 GO:0006402 BP 1 mRNA catabolic process 1 P62312,P62310,Q9Y333 399 3.66e-04 1336 6 5 0.833 0.004 GO:0003723 MF 1 RNA binding 1 O75940,Q96NC0,P62312,P62310,Q9Y333 399 4.10e-04 217 6 3 0.500 0.014 GO:0006401 BP 1 RNA catabolic process 1 P62312,P62310,Q9Y333 399 4.52e-04 2627 6 6 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.03e-03 3013 6 6 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.11e-03 304 6 3 0.500 0.010 GO:0034655 BP 1 nucleobase-containing compound catabolic process 1 P62312,P62310,Q9Y333 399 1.13e-03 3058 6 6 1.000 0.002 GO:0010467 BP 1 gene expression 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.47e-03 334 6 3 0.500 0.009 GO:0046700 BP 1 heterocycle catabolic process 1 P62312,P62310,Q9Y333 399 1.49e-03 336 6 3 0.500 0.009 GO:0044270 BP 1 cellular nitrogen compound catabolic process 1 P62312,P62310,Q9Y333 399 1.55e-03 340 6 3 0.500 0.009 GO:0019439 BP 1 aromatic compound catabolic process 1 P62312,P62310,Q9Y333 399 1.79e-03 357 6 3 0.500 0.008 GO:1901361 BP 1 organic cyclic compound catabolic process 1 P62312,P62310,Q9Y333 399 2.18e-03 1485 6 5 0.833 0.003 REAC:74160 rea 1 Gene Expression 1 P41223,O75940,P62312,P62310,Q9Y333 399 2.30e-03 3443 6 6 1.000 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 2.76e-03 88 6 2 0.333 0.023 GO:0071013 CC 1 catalytic step 2 spliceosome 1 P62310,Q9Y333 399 2.78e-03 3554 6 6 1.000 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 2.81e-03 3561 6 6 1.000 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 3.43e-03 3681 6 6 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 3.59e-03 2136 6 5 0.833 0.002 GO:0003676 MF 1 nucleic acid binding 1 O75940,Q96NC0,P62312,P62310,Q9Y333 399 3.65e-03 1118 6 4 0.667 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 O75940,P62312,P62310,Q9Y333 399 5.08e-03 3 6 1 0.167 0.333 GO:2000825 BP 1 positive regulation of androgen receptor activity 1 P41223 399 5.22e-03 3948 6 6 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 6.77e-03 4 6 1 0.167 0.250 GO:2000823 BP 1 regulation of androgen receptor activity 1 P41223 399 8.29e-03 4264 6 6 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 9.41e-03 2612 6 5 0.833 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.03e-02 2660 6 5 0.833 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.04e-02 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 1.18e-02 7 6 1 0.167 0.143 GO:0033145 BP 1 positive regulation of intracellular steroid hormone receptor signaling pathway 1 P41223 399 1.41e-02 727 6 3 0.500 0.004 GO:0044265 BP 1 cellular macromolecule catabolic process 1 P62312,P62310,Q9Y333 399 1.69e-02 10 6 1 0.167 0.100 GO:0017070 MF 1 U6 snRNA binding 1 Q9Y333 399 1.95e-02 79 6 2 0.333 0.025 CORUM:1181 cor 1 C complex spliceosome 1 P62310,Q9Y333 399 2.03e-02 12 6 1 0.167 0.083 GO:0017160 MF 1 Ral GTPase binding 1 Q9Y333 399 2.13e-02 4990 6 6 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 2.35e-02 3168 6 5 0.833 0.002 GO:0044428 CC 1 nuclear part 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 2.39e-02 876 6 3 0.500 0.003 GO:0009057 BP 1 macromolecule catabolic process 1 P62312,P62310,Q9Y333 399 2.53e-02 15 6 1 0.167 0.067 GO:0005732 CC 1 small nucleolar ribonucleoprotein complex 1 P62312 399 2.70e-02 16 6 1 0.167 0.062 GO:0033962 BP 1 cytoplasmic mRNA processing body assembly 1 P62310 399 2.98e-02 2527 6 4 0.667 0.002 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 P41223,Q96NC0,P62312,Q9Y333 399 3.04e-02 1960 6 4 0.667 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P41223,P62312,P62310,Q9Y333 399 3.04e-02 1960 6 4 0.667 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P41223,P62312,P62310,Q9Y333 399 3.13e-02 5319 6 6 1.000 0.001 GO:0043170 BP 1 macromolecule metabolic process 1 P41223,O75940,Q96NC0,P62312,P62310,Q9Y333 399 3.21e-02 19 6 1 0.167 0.053 GO:2000273 BP 1 positive regulation of receptor activity 1 P41223 399 3.34e-02 3415 6 5 0.833 0.001 GO:0032991 CC 1 macromolecular complex 1 P41223,Q96NC0,P62312,P62310,Q9Y333 399 3.37e-02 20 6 1 0.167 0.050 GO:0060765 BP 1 regulation of androgen receptor signaling pathway 1 P41223 399 4.68e-02 2875 6 4 0.667 0.001 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 P41223,Q96NC0,P62312,Q9Y333 399 5.00e-02 51 6 1 0.167 0.020 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q9Y333 399 5.00e-02 16 6 1 0.167 0.062 CORUM:5613 cor 1 Emerin complex 25 1 Q9Y333 399 5.00e-02 71 6 3 0.500 0.042 KEGG:03018 keg 1 RNA degradation 1 P62312,P62310,Q9Y333 399 5.00e-02 1141 6 3 0.500 0.003 GO:0044248 BP 1 cellular catabolic process 1 P62312,P62310,Q9Y333 399 5.00e-02 82 6 2 0.333 0.024 TF:M03980_0 tf 1 Factor: ETV2; motif: AACCGGAAATR; match class: 0 1 P41223,P62310 399 5.00e-02 403 6 3 0.500 0.007 MI:hsa-miR-583 mi 1 MI:hsa-miR-583 1 Q96NC0,P62312,Q9Y333 400 1.73e-03 505 6 4 0.667 0.008 MI:hsa-miR-548a-5p mi 1 MI:hsa-miR-548a-5p 1 Q9Y2T7,Q96GM8,Q96GA3,Q9BRU9 400 2.08e-03 529 6 4 0.667 0.008 MI:hsa-miR-548b-5p mi 1 MI:hsa-miR-548b-5p 1 Q9Y2T7,Q96GM8,Q96GA3,Q9BRU9 400 6.36e-03 61 6 2 0.333 0.033 GO:0042274 BP 1 ribosomal small subunit biogenesis 1 Q96GA3,Q9BRU9 400 8.13e-03 69 6 2 0.333 0.029 GO:0030684 CC 1 preribosome 1 Q96GA3,Q9BRU9 400 1.62e-02 2 6 1 0.167 0.500 GO:0009386 BP 1 translational attenuation 1 Q9Y2T7 400 3.87e-02 599 6 3 0.500 0.005 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q96GA3,Q9BRU9,Q9UHB9 400 3.89e-02 600 6 3 0.500 0.005 GO:1990904 CC 1 ribonucleoprotein complex 1 Q96GA3,Q9BRU9,Q9UHB9 400 4.05e-02 4308 6 5 0.833 0.001 HPA:046020_02 hpa 1 tonsil; non-germinal center cells[Uncertain,Medium] 1 Q96GM8,Q96GA3,P57071,Q9BRU9,Q9UHB9 400 4.06e-02 5 6 1 0.167 0.200 GO:0000056 BP 1 ribosomal small subunit export from nucleus 1 Q96GA3 400 4.06e-02 5 6 1 0.167 0.200 GO:0034448 CC 1 EGO complex 1 Q96GA3 400 4.06e-02 5 6 1 0.167 0.200 GO:0005047 MF 1 signal recognition particle binding 1 Q9UHB9 400 4.24e-02 477 6 3 0.500 0.006 MI:mmu-miR-878-5p mi 1 MI:mmu-miR-878-5p 1 Q96GM8,Q96GA3,P57071 400 4.25e-02 6377 6 6 1.000 0.001 HPA:021010 hpa 1 liver; bile duct cells 1 Q9Y2T7,Q96GM8,Q96GA3,P57071,Q9BRU9,Q9UHB9 400 4.64e-02 2627 6 5 0.833 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q9Y2T7,Q96GM8,Q96GA3,P57071,Q9BRU9 400 4.79e-02 645 6 3 0.500 0.005 GO:0005730 CC 1 nucleolus 1 Q9Y2T7,Q9BRU9,Q9UHB9 400 4.84e-02 1633 6 3 0.500 0.002 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q96GM8,Q96GA3,P57071 400 4.87e-02 6 6 1 0.167 0.167 GO:0030688 CC 1 preribosome, small subunit precursor 1 Q96GA3 400 4.87e-02 6 6 1 0.167 0.167 GO:0005786 CC 1 signal recognition particle, endoplasmic reticulum targeting 1 Q9UHB9 400 4.87e-02 6 6 1 0.167 0.167 GO:0048500 CC 1 signal recognition particle 1 Q9UHB9 400 5.00e-02 304 6 3 0.500 0.010 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 Q9Y2T7,Q9BRU9,Q9UHB9 400 5.00e-02 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q9Y2T7,Q96GM8,Q96GA3,P57071,Q9BRU9,Q9UHB9 400 5.00e-02 22 6 1 0.167 0.045 KEGG:03060 keg 1 Protein export 1 Q9UHB9 400 5.00e-02 505 6 3 0.500 0.006 MI:mmu-miR-878-3p mi 1 MI:mmu-miR-878-3p 1 Q9Y2T7,Q96GM8,Q9UHB9 400 5.00e-02 14 6 1 0.167 0.071 CORUM:1068 cor 1 12S U11 snRNP 1 Q96GM8 401 2.27e-03 1 2 1 0.500 1.000 GO:1990261 BP 1 pre-mRNA catabolic process 1 O75312 401 2.27e-03 1 2 1 0.500 1.000 GO:2000671 BP 1 regulation of motor neuron apoptotic process 1 O75312 401 2.27e-03 1 2 1 0.500 1.000 GO:2000672 BP 1 negative regulation of motor neuron apoptotic process 1 O75312 401 2.27e-03 1 2 1 0.500 1.000 GO:0001832 BP 1 blastocyst growth 1 O75312 401 2.27e-03 1 2 1 0.500 1.000 GO:0001834 BP 1 trophectodermal cell proliferation 1 O75312 401 2.27e-03 1 2 1 0.500 1.000 GO:0097049 BP 1 motor neuron apoptotic process 1 O75312 401 4.55e-03 2 2 1 0.500 0.500 GO:0030576 BP 1 Cajal body organization 1 O75312 401 4.55e-03 2 2 1 0.500 0.500 GO:0071931 BP 1 positive regulation of transcription involved in G1/S transition of mitotic cell cycle 1 O75312 401 4.55e-03 2 2 1 0.500 0.500 GO:0097504 CC 1 Gemini of coiled bodies 1 O75312 401 1.14e-02 5 2 1 0.500 0.200 GO:0001824 BP 1 blastocyst development 1 O75312 401 1.14e-02 5 2 1 0.500 0.200 GO:0030575 BP 1 nuclear body organization 1 O75312 401 1.70e-02 1408 2 2 1.000 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 Q13442,O75312 401 1.82e-02 8 2 1 0.500 0.125 GO:1902742 BP 1 apoptotic process involved in development 1 O75312 401 1.82e-02 8 2 1 0.500 0.125 GO:0042023 BP 1 DNA endoreduplication 1 O75312 401 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 Q13442,O75312 401 2.27e-02 10 2 1 0.500 0.100 GO:0031641 BP 1 regulation of myelination 1 O75312 401 2.50e-02 11 2 1 0.500 0.091 GO:0032797 CC 1 SMN complex 1 O75312 401 2.96e-02 13 2 1 0.500 0.077 GO:0021510 BP 1 spinal cord development 1 O75312 401 3.41e-02 15 2 1 0.500 0.067 GO:0033120 BP 1 positive regulation of RNA splicing 1 O75312 401 3.64e-02 16 2 1 0.500 0.062 GO:0043204 CC 1 perikaryon 1 O75312 401 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q13442,O75312 401 4.05e-02 2173 2 2 1.000 0.001 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q13442,O75312 401 4.09e-02 18 2 1 0.500 0.056 GO:0071364 BP 1 cellular response to epidermal growth factor stimulus 1 O75312 401 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-377* mi 1 MI:hsa-miR-377* 1 O75312 401 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q13442,O75312 401 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q13442,O75312 401 4.77e-02 21 2 1 0.500 0.048 GO:0070849 BP 1 response to epidermal growth factor 1 O75312 401 4.77e-02 21 2 1 0.500 0.048 GO:0031369 MF 1 translation initiation factor binding 1 O75312 401 5.00e-02 22 2 1 0.500 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 O75312 401 5.00e-02 347 2 2 1.000 0.006 TF:M05640_0 tf 1 Factor: ZNF735; motif: NGGCAGCAGA; match class: 0 1 Q13442,O75312 402 1.17e-04 18 4 2 0.500 0.111 GO:0042026 BP 1 protein refolding 1 O60884,P11142 402 4.32e-04 19 4 2 0.500 0.105 CORUM:2721 cor 1 HCF-1 complex 1 P11142,P51610 402 1.84e-03 70 4 2 0.500 0.029 GO:0051082 MF 1 unfolded protein binding 1 O60884,P11142 402 2.96e-03 1 4 1 0.250 1.000 GO:0061740 BP 1 protein targeting to lysosome involved in chaperone-mediated autophagy 1 P11142 402 2.96e-03 1 4 1 0.250 1.000 GO:0061741 BP 1 chaperone-mediated protein transport involved in chaperone-mediated autophagy 1 P11142 402 2.96e-03 1 4 1 0.250 1.000 GO:0034486 BP 1 vacuolar transmembrane transport 1 P11142 402 2.96e-03 1 4 1 0.250 1.000 GO:1902904 BP 1 negative regulation of fibril organization 1 P11142 402 2.96e-03 1 4 1 0.250 1.000 GO:1904764 BP 1 chaperone-mediated autophagy translocation complex disassembly 1 P11142 402 3.91e-03 2 4 1 0.250 0.500 CORUM:6037 cor 1 CHIP-HSC70 complex 1 P11142 402 4.19e-03 582 4 3 0.750 0.005 GO:0005912 CC 1 adherens junction 1 P11142,P08758,P51610 402 4.39e-03 591 4 3 0.750 0.005 GO:0070161 CC 1 anchoring junction 1 P11142,P08758,P51610 402 5.86e-03 3 4 1 0.250 0.333 CORUM:2129 cor 1 DNAJB2-HSPA8-PSMA3 complex 1 P11142 402 5.91e-03 2 4 1 0.250 0.500 GO:0019046 BP 1 release from viral latency 1 P51610 402 5.91e-03 2 4 1 0.250 0.500 GO:0098575 CC 1 lumenal side of lysosomal membrane 1 P11142 402 5.91e-03 2 4 1 0.250 0.500 GO:0071211 BP 1 protein targeting to vacuole involved in autophagy 1 P11142 402 7.80e-03 4 4 1 0.250 0.250 CORUM:1308 cor 1 PABPC1-HSPA8-HNRPD-EIF4G1 complex 1 P11142 402 7.80e-03 4 4 1 0.250 0.250 CORUM:6052 cor 1 BAG3-HSC70-HSPB8-CHIP complex 1 P11142 402 7.91e-03 8 4 1 0.250 0.125 REAC:447041 rea 1 CHL1 interactions 1 P11142 402 8.67e-03 152 4 2 0.500 0.013 GO:0006457 BP 1 protein folding 1 O60884,P11142 402 8.74e-03 746 4 3 0.750 0.004 GO:0030054 CC 1 cell junction 1 P11142,P08758,P51610 402 8.86e-03 3 4 1 0.250 0.333 GO:1902903 BP 1 regulation of fibril organization 1 P11142 402 8.86e-03 3 4 1 0.250 0.333 GO:0098576 CC 1 lumenal side of membrane 1 P11142 402 9.75e-03 5 4 1 0.250 0.200 CORUM:280 cor 1 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex 1 P11142 402 9.84e-03 162 4 2 0.500 0.012 GO:0031647 BP 1 regulation of protein stability 1 P11142,P51610 402 1.04e-02 7 4 1 0.250 0.143 HP:0010919 hp 1 Abnormality of homocysteine metabolism 1 P51610 402 1.04e-02 7 4 1 0.250 0.143 HP:0002156 hp 1 Homocystinuria 1 P51610 402 1.09e-02 11 4 1 0.250 0.091 REAC:888590 rea 1 GABA synthesis, release, reuptake and degradation 1 P11142 402 1.17e-02 6 4 1 0.250 0.167 CORUM:1256 cor 1 MLL-HCF complex 1 P51610 402 1.17e-02 6 4 1 0.250 0.167 CORUM:1182 cor 1 CDC5L core complex 1 P11142 402 1.17e-02 6 4 1 0.250 0.167 CORUM:2837 cor 1 Profilin 1 complex 1 P11142 402 1.18e-02 4 4 1 0.250 0.250 GO:0055131 MF 1 C3HC4-type RING finger domain binding 1 P11142 402 1.19e-02 8 4 1 0.250 0.125 HP:0002912 hp 1 Methylmalonic acidemia 1 P51610 402 1.48e-02 5 4 1 0.250 0.200 GO:0061635 BP 1 regulation of protein complex stability 1 P11142 402 1.48e-02 5 4 1 0.250 0.200 GO:0061202 CC 1 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 P11142 402 1.48e-02 5 4 1 0.250 0.200 GO:0061200 CC 1 clathrin-sculpted gamma-aminobutyric acid transport vesicle 1 P11142 402 1.54e-02 238 4 2 0.500 0.008 MI:hsa-miR-32* mi 1 MI:hsa-miR-32* 1 O60884,P11142 402 1.56e-02 8 4 1 0.250 0.125 CORUM:1178 cor 1 BCOR complex 1 P11142 402 1.56e-02 8 4 1 0.250 0.125 CORUM:2300 cor 1 Profilin 2 complex 1 P11142 402 1.75e-02 9 4 1 0.250 0.111 CORUM:725 cor 1 P2X7 receptor signalling complex 1 P11142 402 1.77e-02 6 4 1 0.250 0.167 GO:1903054 BP 1 negative regulation of extracellular matrix organization 1 P11142 402 1.78e-02 12 4 1 0.250 0.083 HP:0004341 hp 1 Abnormality of vitamin B12 metabolism 1 P51610 402 1.78e-02 12 4 1 0.250 0.083 HP:0012120 hp 1 Methylmalonic aciduria 1 P51610 402 1.92e-02 13 4 1 0.250 0.077 HP:0004340 hp 1 Abnormality of vitamin B metabolism 1 P51610 402 1.95e-02 229 4 2 0.500 0.009 GO:0043254 BP 1 regulation of protein complex assembly 1 P11142,P51610 402 2.07e-02 7 4 1 0.250 0.143 GO:0060198 CC 1 clathrin-sculpted vesicle 1 P11142 402 2.07e-02 7 4 1 0.250 0.143 GO:0004859 MF 1 phospholipase inhibitor activity 1 P08758 402 2.17e-02 22 4 1 0.250 0.045 REAC:3371568 rea 1 Attenuation phase 1 P11142 402 2.36e-02 8 4 1 0.250 0.125 GO:0072321 BP 1 chaperone-mediated protein transport 1 P11142 402 2.36e-02 8 4 1 0.250 0.125 GO:0070688 CC 1 MLL5-L complex 1 P51610 402 2.66e-02 9 4 1 0.250 0.111 GO:0061684 BP 1 chaperone-mediated autophagy 1 P11142 402 2.73e-02 271 4 2 0.500 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 P11142,P51610 402 2.81e-02 275 4 2 0.500 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 P11142,P51610 402 2.85e-02 277 4 2 0.500 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 P11142,P51610 402 2.95e-02 282 4 2 0.500 0.007 GO:0045296 MF 1 cadherin binding 1 P11142,P51610 402 2.95e-02 10 4 1 0.250 0.100 GO:0043995 MF 1 histone acetyltransferase activity (H4-K5 specific) 1 P51610 402 2.95e-02 10 4 1 0.250 0.100 GO:0043996 MF 1 histone acetyltransferase activity (H4-K8 specific) 1 P51610 402 2.95e-02 10 4 1 0.250 0.100 GO:0046972 MF 1 histone acetyltransferase activity (H4-K16 specific) 1 P51610 402 2.95e-02 10 4 1 0.250 0.100 GO:0019042 BP 1 viral latency 1 P51610 402 2.95e-02 10 4 1 0.250 0.100 GO:0055102 MF 1 lipase inhibitor activity 1 P08758 402 2.95e-02 10 4 1 0.250 0.100 GO:0048188 CC 1 Set1C/COMPASS complex 1 P51610 402 2.95e-02 30 4 1 0.250 0.033 REAC:3371571 rea 1 HSF1-dependent transactivation 1 P11142 402 3.01e-02 334 4 2 0.500 0.006 MI:hsa-miR-192* mi 1 MI:hsa-miR-192* 1 O60884,P11142 402 3.20e-02 294 4 2 0.500 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 P11142,P51610 402 3.25e-02 11 4 1 0.250 0.091 GO:0023026 MF 1 MHC class II protein complex binding 1 P11142 402 3.25e-02 11 4 1 0.250 0.091 GO:0023023 MF 1 MHC protein complex binding 1 P11142 402 3.38e-02 23 4 1 0.250 0.043 HP:0004339 hp 1 Abnormality of sulfur amino acid metabolism 1 P51610 402 3.44e-02 35 4 1 0.250 0.029 REAC:432720 rea 1 Lysosome Vesicle Biogenesis 1 P11142 402 3.44e-02 35 4 1 0.250 0.029 REAC:112310 rea 1 Neurotransmitter Release Cycle 1 P11142 402 3.71e-02 2 4 1 0.250 0.500 TF:M03896_0 tf 1 Factor: EGR1; motif: NACGCCCACGCANW; match class: 0 1 P08758 402 3.76e-02 374 4 2 0.500 0.005 MI:hsa-miR-380 mi 1 MI:hsa-miR-380 1 O60884,P08758 402 3.82e-02 26 4 1 0.250 0.038 HP:0009909 hp 1 Uplifted earlobe 1 P51610 402 3.84e-02 13 4 1 0.250 0.077 GO:0006622 BP 1 protein targeting to lysosome 1 P11142 402 3.84e-02 13 4 1 0.250 0.077 GO:0000974 CC 1 Prp19 complex 1 P11142 402 4.09e-02 333 4 2 0.500 0.006 GO:0005925 CC 1 focal adhesion 1 P11142,P08758 402 4.09e-02 333 4 2 0.500 0.006 GO:0005924 CC 1 cell-substrate adherens junction 1 P11142,P08758 402 4.13e-02 42 4 1 0.250 0.024 REAC:2151201 rea 1 Transcriptional activation of mitochondrial biogenesis 1 P51610 402 4.13e-02 14 4 1 0.250 0.071 GO:0005671 CC 1 Ada2/Gcn5/Ada3 transcription activator complex 1 P51610 402 4.19e-02 337 4 2 0.500 0.006 GO:0030055 CC 1 cell-substrate junction 1 P11142,P08758 402 4.42e-02 15 4 1 0.250 0.067 GO:0043981 BP 1 histone H4-K5 acetylation 1 P51610 402 4.42e-02 15 4 1 0.250 0.067 GO:0043982 BP 1 histone H4-K8 acetylation 1 P51610 402 4.68e-02 32 4 1 0.250 0.031 HP:0010995 hp 1 Abnormality of dicarboxylic acid metabolism 1 P51610 402 4.68e-02 32 4 1 0.250 0.031 HP:0003215 hp 1 Dicarboxylic aciduria 1 P51610 402 4.72e-02 16 4 1 0.250 0.062 GO:0010485 MF 1 H4 histone acetyltransferase activity 1 P51610 402 4.72e-02 16 4 1 0.250 0.062 GO:0061462 BP 1 protein localization to lysosome 1 P11142 402 4.97e-02 34 4 1 0.250 0.029 HP:0000053 hp 1 Macroorchidism 1 P51610 402 5.00e-02 1 4 1 0.250 1.000 OMIM:614391 omi 1 PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 3; RPRGL3 1 P08758 402 5.00e-02 26 4 1 0.250 0.038 CORUM:5386 cor 1 MLL1-WDR5 complex 1 P51610 402 5.00e-02 433 4 2 0.500 0.005 MI:hsa-miR-613 mi 1 MI:hsa-miR-613 1 P11142,P08758 402 5.00e-02 153 4 2 0.500 0.013 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 O60884,P11142 402 5.00e-02 369 4 2 0.500 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 P11142,P51610 402 5.00e-02 152 4 2 0.500 0.013 KEGG:04141 keg 1 Protein processing in endoplasmic reticulum 1 O60884,P11142 402 5.00e-02 51 4 1 0.250 0.020 REAC:1592230 rea 1 Mitochondrial biogenesis 1 P51610 402 5.00e-02 1 4 1 0.250 1.000 OMIM:309541 omi 1 METHYLMALONIC ACIDEMIA AND HOMOCYSTEINEMIA, cblX TYPE;;MENTAL RETARDATION, X-LINKED 3; MRX3 1 P51610 403 6.58e-14 83 9 7 0.778 0.084 GO:0072562 CC 1 blood microparticle 1 P00450,P04217,P02652,P19652,P02763,P00751,P00738 403 2.49e-09 668 9 8 0.889 0.012 GO:0005615 CC 1 extracellular space 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 3.26e-07 68 9 4 0.444 0.059 GO:0060205 CC 1 cytoplasmic vesicle lumen 1 P04217,P19652,P02763,P00738 403 3.46e-07 69 9 4 0.444 0.058 GO:0031983 CC 1 vesicle lumen 1 P04217,P19652,P02763,P00738 403 1.30e-06 2 9 2 0.222 1.000 GO:0060621 BP 1 negative regulation of cholesterol import 1 P02656,P02652 403 1.30e-06 2 9 2 0.222 1.000 GO:2000910 BP 1 negative regulation of sterol import 1 P02656,P02652 403 3.89e-06 3 9 2 0.222 0.667 GO:0070653 MF 1 high-density lipoprotein particle receptor binding 1 P02656,P02652 403 3.89e-06 3 9 2 0.222 0.667 GO:0010901 BP 1 regulation of very-low-density lipoprotein particle remodeling 1 P02656,P02652 403 3.89e-06 3 9 2 0.222 0.667 GO:0060620 BP 1 regulation of cholesterol import 1 P02656,P02652 403 3.89e-06 3 9 2 0.222 0.667 GO:2000909 BP 1 regulation of sterol import 1 P02656,P02652 403 3.89e-06 3 9 2 0.222 0.667 GO:0010903 BP 1 negative regulation of very-low-density lipoprotein particle remodeling 1 P02656,P02652 403 7.77e-06 4 9 2 0.222 0.500 GO:0034372 BP 1 very-low-density lipoprotein particle remodeling 1 P02656,P02652 403 7.77e-06 4 9 2 0.222 0.500 GO:0034370 BP 1 triglyceride-rich lipoprotein particle remodeling 1 P02656,P02652 403 8.89e-06 42 9 3 0.333 0.071 GO:0031093 CC 1 platelet alpha granule lumen 1 P04217,P19652,P02763 403 1.17e-05 46 9 3 0.333 0.065 GO:0002526 BP 1 acute inflammatory response 1 P19652,P02763,P00751 403 1.29e-05 5 9 2 0.222 0.400 GO:0034384 BP 1 high-density lipoprotein particle clearance 1 P02656,P02652 403 1.29e-05 5 9 2 0.222 0.400 GO:0034366 CC 1 spherical high-density lipoprotein particle 1 P02656,P02652 403 1.29e-05 5 9 2 0.222 0.400 GO:0042627 CC 1 chylomicron 1 P02656,P02652 403 1.94e-05 6 9 2 0.222 0.333 GO:0032375 BP 1 negative regulation of cholesterol transport 1 P02656,P02652 403 1.94e-05 6 9 2 0.222 0.333 GO:0032372 BP 1 negative regulation of sterol transport 1 P02656,P02652 403 2.14e-05 56 9 3 0.333 0.054 GO:0031091 CC 1 platelet alpha granule 1 P04217,P19652,P02763 403 2.25e-05 57 9 3 0.333 0.053 GO:0034774 CC 1 secretory granule lumen 1 P04217,P19652,P02763 403 2.72e-05 7 9 2 0.222 0.286 GO:0034364 CC 1 high-density lipoprotein particle 1 P02656,P02652 403 3.04e-05 2194 9 8 0.889 0.004 GO:0070062 CC 1 extracellular exosome 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 3.16e-05 2205 9 8 0.889 0.004 GO:1903561 CC 1 extracellular vesicle 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 3.16e-05 2205 9 8 0.889 0.004 GO:0043230 CC 1 extracellular organelle 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 3.62e-05 8 9 2 0.222 0.250 GO:0060192 BP 1 negative regulation of lipase activity 1 P02656,P02652 403 3.62e-05 8 9 2 0.222 0.250 GO:0034375 BP 1 high-density lipoprotein particle remodeling 1 P02656,P02652 403 3.62e-05 8 9 2 0.222 0.250 GO:0034361 CC 1 very-low-density lipoprotein particle 1 P02656,P02652 403 3.62e-05 8 9 2 0.222 0.250 GO:0035376 BP 1 sterol import 1 P02656,P02652 403 3.62e-05 8 9 2 0.222 0.250 GO:0070508 BP 1 cholesterol import 1 P02656,P02652 403 3.62e-05 8 9 2 0.222 0.250 GO:0034385 CC 1 triglyceride-rich lipoprotein particle 1 P02656,P02652 403 3.88e-05 910 9 6 0.667 0.007 GO:0097708 CC 1 intracellular vesicle 1 P02656,P04217,P02652,P19652,P02763,P00738 403 4.43e-05 931 9 6 0.667 0.006 GO:0031410 CC 1 cytoplasmic vesicle 1 P02656,P04217,P02652,P19652,P02763,P00738 403 4.65e-05 9 9 2 0.222 0.222 GO:0043691 BP 1 reverse cholesterol transport 1 P02656,P02652 403 5.81e-05 78 9 3 0.333 0.038 GO:0002576 BP 1 platelet degranulation 1 P04217,P19652,P02763 403 5.81e-05 10 9 2 0.222 0.200 GO:0033700 BP 1 phospholipid efflux 1 P02656,P02652 403 5.81e-05 10 9 2 0.222 0.200 GO:0055102 MF 1 lipase inhibitor activity 1 P02656,P02652 403 7.10e-05 11 9 2 0.222 0.182 GO:0050995 BP 1 negative regulation of lipid catabolic process 1 P02656,P02652 403 7.10e-05 11 9 2 0.222 0.182 GO:0034358 CC 1 plasma lipoprotein particle 1 P02656,P02652 403 7.10e-05 11 9 2 0.222 0.182 GO:1990777 CC 1 lipoprotein particle 1 P02656,P02652 403 7.79e-05 86 9 3 0.333 0.035 GO:0009895 BP 1 negative regulation of catabolic process 1 P02656,P02652,P00738 403 8.52e-05 12 9 2 0.222 0.167 GO:0034368 BP 1 protein-lipid complex remodeling 1 P02656,P02652 403 8.52e-05 12 9 2 0.222 0.167 GO:0006953 BP 1 acute-phase response 1 P19652,P02763 403 8.52e-05 12 9 2 0.222 0.167 GO:0034369 BP 1 plasma lipoprotein particle remodeling 1 P02656,P02652 403 8.52e-05 12 9 2 0.222 0.167 GO:0034367 BP 1 macromolecular complex remodeling 1 P02656,P02652 403 1.01e-04 13 9 2 0.222 0.154 GO:0032994 CC 1 protein-lipid complex 1 P02656,P02652 403 1.01e-04 13 9 2 0.222 0.154 GO:0034377 BP 1 plasma lipoprotein particle assembly 1 P02656,P02652 403 1.17e-04 14 9 2 0.222 0.143 GO:0032369 BP 1 negative regulation of lipid transport 1 P02656,P02652 403 1.23e-04 2627 9 8 0.889 0.003 GO:0044421 CC 1 extracellular region part 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 1.35e-04 15 9 2 0.222 0.133 GO:0065005 BP 1 protein-lipid complex assembly 1 P02656,P02652 403 1.35e-04 15 9 2 0.222 0.133 GO:0034381 BP 1 plasma lipoprotein particle clearance 1 P02656,P02652 403 1.55e-04 16 9 2 0.222 0.125 GO:0070325 MF 1 lipoprotein particle receptor binding 1 P02656,P02652 403 1.73e-04 2743 9 8 0.889 0.003 GO:0005576 CC 1 extracellular region 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 2.00e-04 2795 9 8 0.889 0.003 GO:0031982 CC 1 vesicle 1 P00450,P02656,P04217,P02652,P19652,P02763,P00751,P00738 403 2.44e-04 20 9 2 0.222 0.100 GO:0071827 BP 1 plasma lipoprotein particle organization 1 P02656,P02652 403 2.76e-04 17 9 2 0.222 0.118 REAC:174800 rea 1 Chylomicron-mediated lipid transport 1 P02656,P02652 403 2.94e-04 99 9 3 0.333 0.030 REAC:114608 rea 1 Platelet degranulation 1 P04217,P19652,P02763 403 2.97e-04 22 9 2 0.222 0.091 GO:0071825 BP 1 protein-lipid complex subunit organization 1 P02656,P02652 403 2.97e-04 22 9 2 0.222 0.091 GO:0046461 BP 1 neutral lipid catabolic process 1 P02656,P02652 403 2.97e-04 22 9 2 0.222 0.091 GO:0046464 BP 1 acylglycerol catabolic process 1 P02656,P02652 403 3.40e-04 104 9 3 0.333 0.029 REAC:76005 rea 1 Response to elevated platelet cytosolic Ca2+ 1 P04217,P19652,P02763 403 3.85e-04 25 9 2 0.222 0.080 GO:0032371 BP 1 regulation of sterol transport 1 P02656,P02652 403 3.85e-04 25 9 2 0.222 0.080 GO:0032374 BP 1 regulation of cholesterol transport 1 P02656,P02652 403 3.85e-04 25 9 2 0.222 0.080 GO:0050994 BP 1 regulation of lipid catabolic process 1 P02656,P02652 403 5.20e-04 29 9 2 0.222 0.069 GO:0097006 BP 1 regulation of plasma lipoprotein particle levels 1 P02656,P02652 403 5.24e-04 163 9 3 0.333 0.018 GO:0030141 CC 1 secretory granule 1 P04217,P19652,P02763 403 5.57e-04 30 9 2 0.222 0.067 GO:0033344 BP 1 cholesterol efflux 1 P02656,P02652 403 6.03e-04 171 9 3 0.333 0.018 GO:0045055 BP 1 regulated exocytosis 1 P04217,P19652,P02763 403 6.64e-04 464 9 4 0.444 0.009 GO:0032940 BP 1 secretion by cell 1 P04217,P02652,P19652,P02763 403 6.76e-04 33 9 2 0.222 0.061 GO:0015485 MF 1 cholesterol binding 1 P02656,P02652 403 7.18e-04 34 9 2 0.222 0.059 GO:0046503 BP 1 glycerolipid catabolic process 1 P02656,P02652 403 7.61e-04 35 9 2 0.222 0.057 GO:0042632 BP 1 cholesterol homeostasis 1 P02656,P02652 403 7.61e-04 35 9 2 0.222 0.057 GO:0055092 BP 1 sterol homeostasis 1 P02656,P02652 403 8.25e-04 491 9 4 0.444 0.008 GO:0046903 BP 1 secretion 1 P04217,P02652,P19652,P02763 403 8.78e-04 499 9 4 0.444 0.008 GO:0044433 CC 1 cytoplasmic vesicle part 1 P04217,P19652,P02763,P00738 403 8.89e-04 958 9 5 0.556 0.005 GO:0016192 BP 1 vesicle-mediated transport 1 P02656,P04217,P19652,P02763,P00738 403 8.98e-04 38 9 2 0.222 0.053 GO:0032934 MF 1 sterol binding 1 P02656,P02652 403 9.96e-04 40 9 2 0.222 0.050 GO:0045833 BP 1 negative regulation of lipid metabolic process 1 P02656,P02652 403 1.06e-03 33 9 2 0.222 0.061 REAC:975634 rea 1 Retinoid metabolism and transport 1 P02656,P02652 403 1.15e-03 43 9 2 0.222 0.047 GO:0015914 BP 1 phospholipid transport 1 P02656,P02652 403 1.15e-03 43 9 2 0.222 0.047 GO:0032368 BP 1 regulation of lipid transport 1 P02656,P02652 403 1.21e-03 44 9 2 0.222 0.045 GO:0060191 BP 1 regulation of lipase activity 1 P02656,P02652 403 1.33e-03 224 9 3 0.333 0.013 GO:0099503 CC 1 secretory vesicle 1 P04217,P19652,P02763 403 1.33e-03 224 9 3 0.333 0.013 GO:0006954 BP 1 inflammatory response 1 P19652,P02763,P00751 403 1.38e-03 47 9 2 0.222 0.043 GO:0001523 BP 1 retinoid metabolic process 1 P02656,P02652 403 1.38e-03 47 9 2 0.222 0.043 GO:0043178 MF 1 alcohol binding 1 P02656,P02652 403 1.50e-03 49 9 2 0.222 0.041 GO:0030301 BP 1 cholesterol transport 1 P02656,P02652 403 1.50e-03 49 9 2 0.222 0.041 GO:0016101 BP 1 diterpenoid metabolic process 1 P02656,P02652 403 1.56e-03 50 9 2 0.222 0.040 GO:0031330 BP 1 negative regulation of cellular catabolic process 1 P02656,P00738 403 1.62e-03 51 9 2 0.222 0.039 GO:0015918 BP 1 sterol transport 1 P02656,P02652 403 1.64e-03 41 9 2 0.222 0.049 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 P02656,P02652 403 1.68e-03 52 9 2 0.222 0.038 GO:0015748 BP 1 organophosphate ester transport 1 P02656,P02652 403 1.71e-03 244 9 3 0.333 0.012 GO:0006887 BP 1 exocytosis 1 P04217,P19652,P02763 403 1.75e-03 53 9 2 0.222 0.038 GO:0005496 MF 1 steroid binding 1 P02656,P02652 403 1.82e-03 54 9 2 0.222 0.037 GO:0006721 BP 1 terpenoid metabolic process 1 P02656,P02652 403 1.87e-03 1 9 1 0.111 1.000 GO:2000296 BP 1 negative regulation of hydrogen peroxide catabolic process 1 P00738 403 1.87e-03 1 9 1 0.111 1.000 GO:0060695 BP 1 negative regulation of cholesterol transporter activity 1 P02652 403 1.87e-03 1 9 1 0.111 1.000 GO:0010982 BP 1 regulation of high-density lipoprotein particle clearance 1 P02656 403 1.87e-03 1 9 1 0.111 1.000 GO:0010987 BP 1 negative regulation of high-density lipoprotein particle clearance 1 P02656 403 1.87e-03 1 9 1 0.111 1.000 GO:0060694 BP 1 regulation of cholesterol transporter activity 1 P02652 403 2.09e-03 58 9 2 0.222 0.034 GO:0006641 BP 1 triglyceride metabolic process 1 P02656,P02652 403 2.34e-03 49 9 2 0.222 0.041 REAC:174824 rea 1 Lipoprotein metabolism 1 P02656,P02652 403 2.63e-03 666 9 4 0.444 0.006 GO:0006952 BP 1 defense response 1 P19652,P02763,P00751,P00738 403 2.77e-03 213 9 3 0.333 0.014 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 P04217,P19652,P02763 403 2.87e-03 68 9 2 0.222 0.029 GO:0006720 BP 1 isoprenoid metabolic process 1 P02656,P02652 403 2.96e-03 69 9 2 0.222 0.029 GO:0055088 BP 1 lipid homeostasis 1 P02656,P02652 403 3.05e-03 70 9 2 0.222 0.029 GO:0006639 BP 1 acylglycerol metabolic process 1 P02656,P02652 403 3.05e-03 70 9 2 0.222 0.029 GO:0006638 BP 1 neutral lipid metabolic process 1 P02656,P02652 403 3.70e-03 2 9 1 0.111 0.500 REAC:173736 rea 1 Alternative complement activation 1 P00751 403 3.73e-03 62 9 2 0.222 0.032 REAC:2187338 rea 1 Visual phototransduction 1 P02656,P02652 403 3.74e-03 2 9 1 0.111 0.500 GO:0046340 BP 1 diacylglycerol catabolic process 1 P02652 403 3.74e-03 2 9 1 0.111 0.500 GO:0031838 CC 1 haptoglobin-hemoglobin complex 1 P00738 403 3.74e-03 2 9 1 0.111 0.500 GO:0010915 BP 1 regulation of very-low-density lipoprotein particle clearance 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:0034382 BP 1 chylomicron remnant clearance 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:0010897 BP 1 negative regulation of triglyceride catabolic process 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:0010989 BP 1 negative regulation of low-density lipoprotein particle clearance 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:2000295 BP 1 regulation of hydrogen peroxide catabolic process 1 P00738 403 3.74e-03 2 9 1 0.111 0.500 GO:0071830 BP 1 triglyceride-rich lipoprotein particle clearance 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:0010916 BP 1 negative regulation of very-low-density lipoprotein particle clearance 1 P02656 403 3.74e-03 2 9 1 0.111 0.500 GO:0008035 MF 1 high-density lipoprotein particle binding 1 P02652 403 4.35e-03 938 9 5 0.556 0.005 REAC:168249 rea 1 Innate Immune System 1 P04217,P19652,P02763,P00751,P00738 403 4.86e-03 350 9 3 0.333 0.009 GO:0009894 BP 1 regulation of catabolic process 1 P02656,P02652,P00738 403 4.90e-03 89 9 2 0.222 0.022 GO:0042157 BP 1 lipoprotein metabolic process 1 P02656,P02652 403 5.15e-03 73 9 2 0.222 0.027 REAC:73923 rea 1 Lipid digestion, mobilization, and transport 1 P02656,P02652 403 5.60e-03 3 9 1 0.111 0.333 GO:0060228 MF 1 phosphatidylcholine-sterol O-acyltransferase activator activity 1 P02652 403 5.60e-03 3 9 1 0.111 0.333 GO:0010727 BP 1 negative regulation of hydrogen peroxide metabolic process 1 P00738 403 5.60e-03 3 9 1 0.111 0.333 GO:0010985 BP 1 negative regulation of lipoprotein particle clearance 1 P02656 403 5.60e-03 3 9 1 0.111 0.333 GO:0004322 MF 1 ferroxidase activity 1 P00450 403 5.60e-03 3 9 1 0.111 0.333 GO:0030492 MF 1 hemoglobin binding 1 P00738 403 5.60e-03 3 9 1 0.111 0.333 GO:0016724 MF 1 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 1 P00450 403 5.60e-03 3 9 1 0.111 0.333 GO:0051005 BP 1 negative regulation of lipoprotein lipase activity 1 P02656 403 5.60e-03 3 9 1 0.111 0.333 GO:0006957 BP 1 complement activation, alternative pathway 1 P00751 403 5.60e-03 3 9 1 0.111 0.333 GO:0002740 BP 1 negative regulation of cytokine secretion involved in immune response 1 P02652 403 5.60e-03 3 9 1 0.111 0.333 GO:0034363 CC 1 intermediate-density lipoprotein particle 1 P02656 403 6.17e-03 100 9 2 0.222 0.020 GO:0015850 BP 1 organic hydroxy compound transport 1 P02656,P02652 403 6.41e-03 102 9 2 0.222 0.020 GO:0001818 BP 1 negative regulation of cytokine production 1 P02652,P02763 403 7.04e-03 1498 9 5 0.556 0.003 GO:0044765 BP 1 single-organism transport 1 P02656,P04217,P02652,P19652,P02763 403 7.21e-03 1 9 1 0.111 1.000 OMIM:614081 omi 1 ANHAPTOGLOBINEMIA; AHP;;AHAPTOGLOBINEMIAHYPOHAPTOGLOBINEMIA, INCLUDED 1 P00738 403 7.21e-03 1 9 1 0.111 1.000 OMIM:614028 omi 1 APOLIPOPROTEIN C-III DEFICIENCY;;HYPERALPHALIPOPROTEINEMIA 2; HALP2 1 P02656 403 7.21e-03 1 9 1 0.111 1.000 OMIM:604290 omi 1 ACERULOPLASMINEMIAHYPOCERULOPLASMINEMIA, INCLUDED;;CERULOPLASMIN DEFICIENCY, INCLUDED;;HEMOSIDEROSIS, SYSTEMIC, DUE TO ACERULOPLASMINEMIA, INCLUDED 1 P00450 403 7.47e-03 4 9 1 0.111 0.250 GO:0010896 BP 1 regulation of triglyceride catabolic process 1 P02656 403 7.47e-03 4 9 1 0.111 0.250 GO:0010988 BP 1 regulation of low-density lipoprotein particle clearance 1 P02656 403 7.47e-03 4 9 1 0.111 0.250 GO:0034447 BP 1 very-low-density lipoprotein particle clearance 1 P02656 403 7.47e-03 4 9 1 0.111 0.250 GO:0045416 BP 1 positive regulation of interleukin-8 biosynthetic process 1 P02652 403 7.47e-03 4 9 1 0.111 0.250 GO:0090209 BP 1 negative regulation of triglyceride metabolic process 1 P02656 403 7.47e-03 4 9 1 0.111 0.250 GO:0018158 BP 1 protein oxidation 1 P02652 403 8.07e-03 418 9 3 0.333 0.007 GO:0051241 BP 1 negative regulation of multicellular organismal process 1 P02656,P02652,P02763 403 8.13e-03 419 9 3 0.333 0.007 GO:0043086 BP 1 negative regulation of catalytic activity 1 P02656,P02652,P00738 403 8.40e-03 1 9 1 0.111 1.000 HP:0012184 hp 1 Hyperalphalipoproteinemia 1 P02656 403 9.33e-03 5 9 1 0.111 0.200 GO:0002739 BP 1 regulation of cytokine secretion involved in immune response 1 P02652 403 9.33e-03 5 9 1 0.111 0.200 GO:0032489 BP 1 regulation of Cdc42 protein signal transduction 1 P02656 403 9.33e-03 5 9 1 0.111 0.200 GO:0010873 BP 1 positive regulation of cholesterol esterification 1 P02652 403 9.33e-03 5 9 1 0.111 0.200 GO:0010984 BP 1 regulation of lipoprotein particle clearance 1 P02656 403 9.33e-03 5 9 1 0.111 0.200 GO:0034380 BP 1 high-density lipoprotein particle assembly 1 P02652 403 9.56e-03 125 9 2 0.222 0.016 GO:0044242 BP 1 cellular lipid catabolic process 1 P02656,P02652 403 1.09e-02 1652 9 5 0.556 0.003 GO:1902578 BP 1 single-organism localization 1 P02656,P04217,P02652,P19652,P02763 403 1.11e-02 6 9 1 0.111 0.167 REAC:174577 rea 1 Activation of C3 and C5 1 P00751 403 1.11e-02 6 9 1 0.111 0.167 REAC:6814848 rea 1 Glycerophospholipid catabolism 1 Q8N9F7 403 1.12e-02 6 9 1 0.111 0.167 GO:0034190 MF 1 apolipoprotein receptor binding 1 P02652 403 1.12e-02 6 9 1 0.111 0.167 GO:0045414 BP 1 regulation of interleukin-8 biosynthetic process 1 P02652 403 1.12e-02 6 9 1 0.111 0.167 GO:0051004 BP 1 regulation of lipoprotein lipase activity 1 P02656 403 1.12e-02 6 9 1 0.111 0.167 GO:0034379 BP 1 very-low-density lipoprotein particle assembly 1 P02656 403 1.12e-02 6 9 1 0.111 0.167 GO:0034374 BP 1 low-density lipoprotein particle remodeling 1 P02652 403 1.23e-02 142 9 2 0.222 0.014 GO:0016042 BP 1 lipid catabolic process 1 P02656,P02652 403 1.24e-02 143 9 2 0.222 0.014 GO:0006869 BP 1 lipid transport 1 P02656,P02652 403 1.29e-02 146 9 2 0.222 0.014 GO:0006898 BP 1 receptor-mediated endocytosis 1 P02656,P00738 403 1.31e-02 7 9 1 0.111 0.143 GO:0010872 BP 1 regulation of cholesterol esterification 1 P02652 403 1.31e-02 7 9 1 0.111 0.143 GO:0032488 BP 1 Cdc42 protein signal transduction 1 P02656 403 1.31e-02 7 9 1 0.111 0.143 GO:0002374 BP 1 cytokine secretion involved in immune response 1 P02652 403 1.31e-02 7 9 1 0.111 0.143 GO:0010310 BP 1 regulation of hydrogen peroxide metabolic process 1 P00738 403 1.31e-02 7 9 1 0.111 0.143 GO:0042228 BP 1 interleukin-8 biosynthetic process 1 P02652 403 1.31e-02 147 9 2 0.222 0.014 GO:0019216 BP 1 regulation of lipid metabolic process 1 P02656,P02652 403 1.43e-02 512 9 3 0.333 0.006 GO:0048878 BP 1 chemical homeostasis 1 P00450,P02656,P02652 403 1.45e-02 155 9 2 0.222 0.013 GO:0002697 BP 1 regulation of immune effector process 1 P02652,P00751 403 1.49e-02 126 9 2 0.222 0.016 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P02656,P02652 403 1.49e-02 8 9 1 0.111 0.125 GO:0002719 BP 1 negative regulation of cytokine production involved in immune response 1 P02652 403 1.51e-02 2644 9 6 0.667 0.002 GO:0006810 BP 1 transport 1 P02656,P04217,P02652,P19652,P02763,P00738 403 1.62e-02 164 9 2 0.222 0.012 GO:0010876 BP 1 lipid localization 1 P02656,P02652 403 1.64e-02 165 9 2 0.222 0.012 GO:0005769 CC 1 early endosome 1 P02656,P02652 403 1.66e-02 9 9 1 0.111 0.111 REAC:2168880 rea 1 Scavenging of heme from plasma 1 P00738 403 1.68e-02 2 9 1 0.111 0.500 HP:0012153 hp 1 Hypotriglyceridemia 1 P02656 403 1.68e-02 9 9 1 0.111 0.111 GO:0002701 BP 1 negative regulation of production of molecular mediator of immune response 1 P02652 403 1.68e-02 9 9 1 0.111 0.111 GO:0034433 BP 1 steroid esterification 1 P02652 403 1.68e-02 9 9 1 0.111 0.111 GO:0046339 BP 1 diacylglycerol metabolic process 1 P02652 403 1.68e-02 9 9 1 0.111 0.111 GO:0045717 BP 1 negative regulation of fatty acid biosynthetic process 1 P02656 403 1.68e-02 9 9 1 0.111 0.111 GO:0034434 BP 1 sterol esterification 1 P02652 403 1.68e-02 9 9 1 0.111 0.111 GO:0001848 MF 1 complement binding 1 P00751 403 1.68e-02 9 9 1 0.111 0.111 GO:0034435 BP 1 cholesterol esterification 1 P02652 403 1.71e-02 258 9 2 0.222 0.008 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 Q8N9F7,P00738 403 1.74e-02 170 9 2 0.222 0.012 GO:0051346 BP 1 negative regulation of hydrolase activity 1 P02656,P02652 403 1.86e-02 2748 9 6 0.667 0.002 GO:0051234 BP 1 establishment of localization 1 P02656,P04217,P02652,P19652,P02763,P00738 403 1.86e-02 10 9 1 0.111 0.100 GO:0034383 BP 1 low-density lipoprotein particle clearance 1 P02656 403 1.86e-02 10 9 1 0.111 0.100 GO:0016722 MF 1 oxidoreductase activity, oxidizing metal ions 1 P00450 403 1.93e-02 570 9 3 0.333 0.005 GO:0044092 BP 1 negative regulation of molecular function 1 P02656,P02652,P00738 403 2.05e-02 11 9 1 0.111 0.091 GO:0048261 BP 1 negative regulation of receptor-mediated endocytosis 1 P02656 403 2.05e-02 11 9 1 0.111 0.091 GO:0051354 BP 1 negative regulation of oxidoreductase activity 1 P00738 403 2.05e-02 11 9 1 0.111 0.091 GO:0017127 MF 1 cholesterol transporter activity 1 P02652 403 2.18e-02 444 9 3 0.333 0.007 REAC:109582 rea 1 Hemostasis 1 P04217,P19652,P02763 403 2.21e-02 12 9 1 0.111 0.083 REAC:166663 rea 1 Initial triggering of complement 1 P00751 403 2.23e-02 12 9 1 0.111 0.083 GO:0050996 BP 1 positive regulation of lipid catabolic process 1 P02652 403 2.23e-02 12 9 1 0.111 0.083 GO:0042744 BP 1 hydrogen peroxide catabolic process 1 P00738 403 2.23e-02 12 9 1 0.111 0.083 GO:0045940 BP 1 positive regulation of steroid metabolic process 1 P02652 403 2.23e-02 12 9 1 0.111 0.083 GO:0071814 MF 1 protein-lipid complex binding 1 P02652 403 2.23e-02 12 9 1 0.111 0.083 GO:0071813 MF 1 lipoprotein particle binding 1 P02652 403 2.23e-02 12 9 1 0.111 0.083 GO:0018206 BP 1 peptidyl-methionine modification 1 P02652 403 2.42e-02 13 9 1 0.111 0.077 GO:0055090 BP 1 acylglycerol homeostasis 1 P02656 403 2.42e-02 13 9 1 0.111 0.077 GO:0071682 CC 1 endocytic vesicle lumen 1 P00738 403 2.42e-02 13 9 1 0.111 0.077 GO:0050997 MF 1 quaternary ammonium group binding 1 P02652 403 2.42e-02 13 9 1 0.111 0.077 GO:0070328 BP 1 triglyceride homeostasis 1 P02656 403 2.42e-02 13 9 1 0.111 0.077 GO:0031210 MF 1 phosphatidylcholine binding 1 P02652 403 2.58e-02 14 9 1 0.111 0.071 REAC:977606 rea 1 Regulation of Complement cascade 1 P00751 403 2.60e-02 14 9 1 0.111 0.071 GO:0045922 BP 1 negative regulation of fatty acid metabolic process 1 P02656 403 2.61e-02 210 9 2 0.222 0.010 GO:0015711 BP 1 organic anion transport 1 P02656,P02652 403 2.78e-02 217 9 2 0.222 0.009 GO:0004857 MF 1 enzyme inhibitor activity 1 P02656,P02652 403 2.79e-02 15 9 1 0.111 0.067 GO:0019433 BP 1 triglyceride catabolic process 1 P02656 403 2.79e-02 15 9 1 0.111 0.067 GO:0090207 BP 1 regulation of triglyceride metabolic process 1 P02656 403 2.88e-02 221 9 2 0.222 0.009 GO:0051051 BP 1 negative regulation of transport 1 P02656,P02652 403 2.94e-02 16 9 1 0.111 0.062 REAC:194223 rea 1 HDL-mediated lipid transport 1 P02656 403 2.97e-02 16 9 1 0.111 0.062 GO:0015248 MF 1 sterol transporter activity 1 P02652 403 2.97e-02 16 9 1 0.111 0.062 GO:0032715 BP 1 negative regulation of interleukin-6 production 1 P02763 403 3.00e-02 1457 9 5 0.556 0.003 REAC:168256 rea 1 Immune System 1 P04217,P19652,P02763,P00751,P00738 403 3.05e-02 351 9 2 0.222 0.006 MI:hsa-miR-135b* mi 1 MI:hsa-miR-135b* 1 P02652,P00738 403 3.16e-02 17 9 1 0.111 0.059 GO:2000378 BP 1 negative regulation of reactive oxygen species metabolic process 1 P00738 403 3.19e-02 360 9 2 0.222 0.006 MI:mmu-miR-692 mi 1 MI:mmu-miR-692 1 P00450,P02656 403 3.34e-02 4 9 1 0.111 0.250 HP:0005381 hp 1 Recurrent meningococcal disease 1 P00751 403 3.34e-02 4 9 1 0.111 0.250 HP:0005430 hp 1 Recurrent Neisserial infections 1 P00751 403 3.34e-02 4 9 1 0.111 0.250 HP:0005416 hp 1 Decreased serum complement factor B 1 P00751 403 3.34e-02 4 9 1 0.111 0.250 HP:0002396 hp 1 Cogwheel rigidity 1 P00450 403 3.35e-02 239 9 2 0.222 0.008 GO:0046486 BP 1 glycerolipid metabolic process 1 P02656,P02652 403 3.38e-02 240 9 2 0.222 0.008 GO:0005543 MF 1 phospholipid binding 1 P02656,P02652 403 3.49e-02 19 9 1 0.111 0.053 REAC:425410 rea 1 Metal ion SLC transporters 1 P00450 403 3.53e-02 19 9 1 0.111 0.053 GO:2000257 BP 1 regulation of protein activation cascade 1 P00751 403 3.53e-02 19 9 1 0.111 0.053 GO:0030449 BP 1 regulation of complement activation 1 P00751 403 3.53e-02 19 9 1 0.111 0.053 GO:0009395 BP 1 phospholipid catabolic process 1 P02652 403 3.53e-02 19 9 1 0.111 0.053 GO:0042304 BP 1 regulation of fatty acid biosynthetic process 1 P02656 403 3.53e-02 19 9 1 0.111 0.053 GO:0032720 BP 1 negative regulation of tumor necrosis factor production 1 P02763 403 3.58e-02 5 9 1 0.111 0.200 OMIM:143890 omi 1 HYPERCHOLESTEROLEMIA, FAMILIAL;;FHC; FH;;HYPERLIPOPROTEINEMIA, TYPE II;;HYPERLIPOPROTEINEMIA, TYPE IIA;;HYPER-LOW-DENSITY-LIPOPROTEINEMIA;;HYPERCHOLESTEROLEMIC XANTHOMATOSIS, FAMILIAL;;LDL RECEPTOR DISORDERLOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS2, INCLUDED; LDLCQ2, INCLUDED 1 P02652 403 3.71e-02 20 9 1 0.111 0.050 GO:0042108 BP 1 positive regulation of cytokine biosynthetic process 1 P02652 403 3.76e-02 393 9 2 0.222 0.005 MI:hsa-miR-578 mi 1 MI:hsa-miR-578 1 P02656,Q8N9F7 403 3.90e-02 21 9 1 0.111 0.048 GO:0002920 BP 1 regulation of humoral immune response 1 P00751 403 3.90e-02 21 9 1 0.111 0.048 GO:0042743 BP 1 hydrogen peroxide metabolic process 1 P00738 403 3.90e-02 21 9 1 0.111 0.048 GO:0006656 BP 1 phosphatidylcholine biosynthetic process 1 P02652 403 3.90e-02 21 9 1 0.111 0.048 GO:1903556 BP 1 negative regulation of tumor necrosis factor superfamily cytokine production 1 P02763 403 4.03e-02 22 9 1 0.111 0.045 REAC:166658 rea 1 Complement cascade 1 P00751 403 4.04e-02 409 9 2 0.222 0.005 MI:hsa-miR-708 mi 1 MI:hsa-miR-708 1 P02656,P02652 403 4.05e-02 264 9 2 0.222 0.008 GO:0006820 BP 1 anion transport 1 P02656,P02652 403 4.17e-02 5 9 1 0.111 0.200 HP:0001937 hp 1 Microangiopathic hemolytic anemia 1 P00751 403 4.19e-02 417 9 2 0.222 0.005 MI:hsa-miR-512-5p mi 1 MI:hsa-miR-512-5p 1 Q8N9F7,P00738 403 4.26e-02 421 9 2 0.222 0.005 MI:hsa-miR-30c-1* mi 1 MI:hsa-miR-30c-1* 1 P02656,P02652 403 4.27e-02 23 9 1 0.111 0.043 GO:0050710 BP 1 negative regulation of cytokine secretion 1 P02652 403 4.28e-02 272 9 2 0.222 0.007 GO:0031329 BP 1 regulation of cellular catabolic process 1 P02656,P00738 403 4.29e-02 2260 9 5 0.556 0.002 GO:0012505 CC 1 endomembrane system 1 P02656,P04217,P02652,P19652,P02763 403 4.52e-02 435 9 2 0.222 0.005 MI:hsa-miR-145 mi 1 MI:hsa-miR-145 1 P00450,P02656 403 4.60e-02 783 9 3 0.333 0.004 GO:0042592 BP 1 homeostatic process 1 P00450,P02656,P02652 403 4.61e-02 283 9 2 0.222 0.007 GO:0001817 BP 1 regulation of cytokine production 1 P02652,P02763 403 4.63e-02 25 9 1 0.111 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 P02656 403 4.63e-02 25 9 1 0.111 0.040 GO:0002718 BP 1 regulation of cytokine production involved in immune response 1 P02652 403 4.82e-02 26 9 1 0.111 0.038 GO:0045806 BP 1 negative regulation of endocytosis 1 P02656 403 4.99e-02 459 9 2 0.222 0.004 MI:hsa-miR-608 mi 1 MI:hsa-miR-608 1 P02656,P02652 403 5.00e-02 6 9 1 0.111 0.167 HP:0100519 hp 1 Anuria 1 P00751 403 5.00e-02 6 9 1 0.111 0.167 HP:0011037 hp 1 Decreased urine output 1 P00751 403 5.00e-02 53 9 2 0.222 0.038 KEGG:03320 keg 1 PPAR signaling pathway 1 P02656,P02652 403 5.00e-02 6 9 1 0.111 0.167 HP:0003138 hp 1 Increased blood urea nitrogen 1 P00751 403 5.00e-02 7 9 1 0.111 0.143 OMIM:234200 omi 1 Neurodegeneration with Brain Iron Accumulation 1 P00450 403 5.00e-02 606 9 3 0.333 0.005 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 P02656,Q8N9F7,P02652 403 5.00e-02 27 9 1 0.111 0.037 GO:0032757 BP 1 positive regulation of interleukin-8 production 1 P02652 404 2.28e-03 1 3 1 0.333 1.000 GO:0047939 MF 1 L-glucuronate reductase activity 1 P14550 404 4.26e-03 428 3 2 0.667 0.005 MI:mmu-miR-666-3p mi 1 MI:mmu-miR-666-3p 1 P14550,Q01995 404 5.84e-03 502 3 2 0.667 0.004 MI:hsa-miR-449b mi 1 MI:hsa-miR-449b 1 P14550,Q01995 404 8.09e-03 5 3 1 0.333 0.200 REAC:5661270 rea 1 Catabolism of glucuronate to xylulose-5-phosphate 1 P14550 404 1.14e-02 5 3 1 0.333 0.200 GO:0019640 BP 1 glucuronate catabolic process to xylulose 5-phosphate 1 P14550 404 1.14e-02 5 3 1 0.333 0.200 GO:0051167 BP 1 xylulose 5-phosphate metabolic process 1 P14550 404 1.14e-02 5 3 1 0.333 0.200 GO:0006064 BP 1 glucuronate catabolic process 1 P14550 404 1.14e-02 5 3 1 0.333 0.200 GO:1901159 BP 1 xylulose 5-phosphate biosynthetic process 1 P14550 404 1.37e-02 6 3 1 0.333 0.167 GO:0004032 MF 1 alditol:NADP+ 1-oxidoreductase activity 1 P14550 404 2.03e-02 25 3 1 0.333 0.040 KEGG:00040 keg 1 Pentose and glucuronate interconversions 1 P14550 404 2.90e-02 1140 3 2 0.667 0.002 MI:gga-miR-000 mi 1 gga miRBase microRNAs 1 P14550,Q01995 404 2.96e-02 13 3 1 0.333 0.077 GO:0008106 MF 1 alcohol dehydrogenase (NADP+) activity 1 P14550 404 3.88e-02 48 3 1 0.333 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 P14550 404 4.55e-02 20 3 1 0.333 0.050 GO:1901687 BP 1 glutathione derivative biosynthetic process 1 P14550 404 4.55e-02 20 3 1 0.333 0.050 GO:1901685 BP 1 glutathione derivative metabolic process 1 P14550 404 5.00e-02 66 3 2 0.667 0.030 TF:M05866_0 tf 1 Factor: ZNF491; motif: KGGGGCAACAGW; match class: 0 1 P14550,Q01995 404 5.00e-02 22 3 1 0.333 0.045 GO:0006063 BP 1 uronic acid metabolic process 1 P14550 404 5.00e-02 31 3 1 0.333 0.032 REAC:156590 rea 1 Glutathione conjugation 1 P14550 404 5.00e-02 22 3 1 0.333 0.045 GO:0019585 BP 1 glucuronate metabolic process 1 P14550 404 5.00e-02 22 3 1 0.333 0.045 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 P14550 404 5.00e-02 62 3 1 0.333 0.016 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P14550 405 2.22e-02 4 2 1 0.500 0.250 HP:0006896 hp 1 Hypnopompic hallucinations 1 Q16653 405 2.22e-02 4 2 1 0.500 0.250 HP:0002519 hp 1 Hypnagogic hallucinations 1 Q16653 405 2.22e-02 4 2 1 0.500 0.250 HP:0002330 hp 1 Paroxysmal drowsiness 1 Q16653 405 2.22e-02 4 2 1 0.500 0.250 HP:0002494 hp 1 Abnormal rapid eye movement sleep 1 Q16653 405 2.78e-02 5 2 1 0.500 0.200 HP:0030050 hp 1 Narcolepsy 1 Q16653 405 3.71e-02 786 2 2 1.000 0.003 TF:M00773_1 tf 1 Factor: c-MYB; motif: NNNGNCAGTTN; match class: 1 1 Q8NFY9,Q16653 405 3.89e-02 7 2 1 0.500 0.143 HP:0002524 hp 1 Cataplexy 1 Q16653 405 3.98e-02 26 2 1 0.500 0.038 TF:M06341_0 tf 1 Factor: ZNF790; motif: NGGTGCAWATGA; match class: 0 1 Q8NFY9 405 3.98e-02 26 2 1 0.500 0.038 TF:M07104_0 tf 1 Factor: JunD; motif: NRTGASTCATN; match class: 0 1 Q8NFY9 405 4.21e-02 238 2 1 0.500 0.004 MI:hsa-miR-32* mi 1 MI:hsa-miR-32* 1 Q16653 405 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-877* mi 1 MI:hsa-miR-877* 1 Q16653 405 4.80e-02 894 2 2 1.000 0.002 TF:M07218_0 tf 1 Factor: MEF-2A; motif: NKCTAAAAATAGMNN; match class: 0 1 Q8NFY9,Q16653 405 4.90e-02 278 2 1 0.500 0.004 MI:hsa-miR-550* mi 1 MI:hsa-miR-550* 1 Q16653 405 5.00e-02 9 2 1 0.500 0.111 HP:0002329 hp 1 Drowsiness 1 Q16653 405 5.00e-02 49 2 1 0.500 0.020 GO:0031463 CC 1 Cul3-RING ubiquitin ligase complex 1 Q8NFY9 406 3.17e-03 419 3 2 0.667 0.005 TF:M05469_0 tf 1 Factor: Sall1; motif: CAWTGCGYA; match class: 0 1 Q8WXF1,A1X283 406 3.53e-03 442 3 2 0.667 0.005 TF:M00616_0 tf 1 Factor: AFP1; motif: ATTAAYTRCAC; match class: 0 1 Q13822,A1X283 406 4.07e-03 475 3 2 0.667 0.004 TF:M00332_0 tf 1 Factor: Whn; motif: ANNGACGCTNN; match class: 0 1 Q13822,A1X283 406 5.41e-03 23 3 1 0.333 0.043 TF:M01202_0 tf 1 Factor: VDR:RXR; motif: GGGTCAWNGRGTTCA; match class: 0 1 Q13822 406 5.88e-03 25 3 1 0.333 0.040 TF:M06036_0 tf 1 Factor: ZNF264; motif: NGKTTCATCAGM; match class: 0 1 A1X283 406 7.19e-03 634 3 2 0.667 0.003 TF:M03939_0 tf 1 Factor: ZNF740; motif: CCCCCCCCAC; match class: 0 1 Q8WXF1,A1X283 406 8.46e-03 36 3 1 0.333 0.028 TF:M06354_0 tf 1 Factor: ZNF449; motif: GTWTAAKASGGC; match class: 0 1 A1X283 406 1.06e-02 45 3 1 0.333 0.022 TF:M00095_1 tf 1 Factor: CDP; motif: CCAATAATCGAT; match class: 1 1 Q8WXF1 406 1.10e-02 47 3 1 0.333 0.021 TF:M06484_0 tf 1 Factor: ZNF683; motif: TTCCYAAATGC; match class: 0 1 A1X283 406 1.53e-02 3160 3 3 1.000 0.001 TF:M00130_1 tf 1 Factor: FOXD3; motif: NAWTGTTTRTTT; match class: 1 1 Q8WXF1,Q13822,A1X283 406 1.57e-02 944 3 2 0.667 0.002 TF:M00188_1 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 1 1 Q8WXF1,A1X283 406 1.57e-02 67 3 1 0.333 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 A1X283 406 1.63e-02 3226 3 3 1.000 0.001 TF:M00765_0 tf 1 Factor: COUP; motif: TGACCTTTGACCC; match class: 0 1 Q8WXF1,Q13822,A1X283 406 1.82e-02 4 3 1 0.333 0.250 GO:0004528 MF 1 phosphodiesterase I activity 1 Q13822 406 1.82e-02 4 3 1 0.333 0.250 GO:0016176 MF 1 superoxide-generating NADPH oxidase activator activity 1 A1X283 406 1.94e-02 83 3 1 0.333 0.012 TF:M05381_1 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 1 1 Q13822 406 2.09e-02 2974 3 3 1.000 0.001 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 Q8WXF1,Q13822,A1X283 406 2.27e-02 1142 3 2 0.667 0.002 TF:M04436_1 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 1 1 Q13822,A1X283 406 2.27e-02 5 3 1 0.333 0.200 GO:0034638 BP 1 phosphatidylcholine catabolic process 1 Q13822 406 2.45e-02 1187 3 2 0.667 0.002 TF:M00410_1 tf 1 Factor: SOX9; motif: NNNNAACAATRGNN; match class: 1 1 Q13822,A1X283 406 2.76e-02 3848 3 3 1.000 0.001 TF:M03888_1 tf 1 Factor: Sox6; motif: NARACAAAARN; match class: 1 1 Q8WXF1,Q13822,A1X283 406 2.85e-02 122 3 1 0.333 0.008 TF:M07092_0 tf 1 Factor: Fra-2; motif: NRRTGASTCAB; match class: 0 1 A1X283 406 2.89e-02 1294 3 2 0.667 0.002 TF:M05464_0 tf 1 Factor: Sall1; motif: NAKKCGKAAAKG; match class: 0 1 Q8WXF1,A1X283 406 3.11e-02 1345 3 2 0.667 0.001 TF:M02064_0 tf 1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 0 1 Q13822,A1X283 406 3.18e-02 7 3 1 0.333 0.143 GO:0010314 MF 1 phosphatidylinositol-5-phosphate binding 1 A1X283 406 3.18e-02 7 3 1 0.333 0.143 GO:2000394 BP 1 positive regulation of lamellipodium morphogenesis 1 Q13822 406 3.24e-02 1374 3 2 0.667 0.001 TF:M00478_0 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 0 1 Q13822,A1X283 406 3.25e-02 4063 3 3 1.000 0.001 TF:M02269_0 tf 1 Factor: FEV; motif: CAGGAART; match class: 0 1 Q8WXF1,Q13822,A1X283 406 3.34e-02 374 3 2 0.667 0.005 MI:hsa-miR-633 mi 1 MI:hsa-miR-633 1 Q8WXF1,Q13822 406 3.40e-02 146 3 1 0.333 0.007 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 Q8WXF1 406 3.49e-02 4160 3 3 1.000 0.001 TF:M04078_0 tf 1 Factor: POU3F2; motif: NWTGCATAAWTTA; match class: 0 1 Q8WXF1,Q13822,A1X283 406 3.57e-02 4190 3 3 1.000 0.001 TF:M04436_0 tf 1 Factor: RHOXF1; motif: GGMTNATCC; match class: 0 1 Q8WXF1,Q13822,A1X283 406 3.57e-02 4190 3 3 1.000 0.001 TF:M00747_1 tf 1 Factor: IRF-1; motif: TTCACTT; match class: 1 1 Q8WXF1,Q13822,A1X283 406 3.57e-02 387 3 2 0.667 0.005 MI:hsa-miR-340 mi 1 MI:hsa-miR-340 1 Q8WXF1,Q13822 406 3.86e-02 166 3 1 0.333 0.006 TF:M04623_1 tf 1 Factor: Otx2; motif: YTAATCCN; match class: 1 1 A1X283 406 3.86e-02 166 3 1 0.333 0.006 TF:M04505_1 tf 1 Factor: PITX1; motif: NTAATCCN; match class: 1 1 A1X283 406 3.87e-02 4305 3 3 1.000 0.001 TF:M04081_0 tf 1 Factor: POU3F3; motif: WTGMATAAWTWA; match class: 0 1 Q8WXF1,Q13822,A1X283 406 3.95e-02 170 3 1 0.333 0.006 TF:M02021_1 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 1 1 Q8WXF1 406 4.03e-02 147 3 1 0.333 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 Q8WXF1 406 4.06e-02 148 3 1 0.333 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 Q8WXF1 406 4.06e-02 1310 3 2 0.667 0.002 HPA:046020_03 hpa 1 tonsil; non-germinal center cells[Uncertain,High] 1 Q8WXF1,Q13822 406 4.07e-02 4378 3 3 1.000 0.001 TF:M07285_0 tf 1 Factor: ESE-1; motif: NNYTTCCTG; match class: 0 1 Q8WXF1,Q13822,A1X283 406 4.09e-02 9 3 1 0.333 0.111 GO:0060612 BP 1 adipose tissue development 1 A1X283 406 4.09e-02 9 3 1 0.333 0.111 GO:2000392 BP 1 regulation of lamellipodium morphogenesis 1 Q13822 406 4.11e-02 1554 3 2 0.667 0.001 TF:M04012_0 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 0 1 Q8WXF1,A1X283 406 4.31e-02 426 3 2 0.667 0.005 MI:hsa-miR-381 mi 1 MI:hsa-miR-381 1 Q8WXF1,Q13822 406 4.71e-02 3899 3 3 1.000 0.001 HPA:035020_02 hpa 1 skin 1; fibroblasts[Uncertain,Medium] 1 Q8WXF1,Q13822,A1X283 406 4.87e-02 453 3 2 0.667 0.004 MI:hsa-miR-300 mi 1 MI:hsa-miR-300 1 Q8WXF1,Q13822 406 4.89e-02 211 3 1 0.333 0.005 TF:M05594_0 tf 1 Factor: Staf; motif: GTTTACAAACG; match class: 0 1 Q13822 406 4.92e-02 4665 3 3 1.000 0.001 TF:M00117_1 tf 1 Factor: C/EBPbeta; motif: NKNTTGCNYAAYNN; match class: 1 1 Q8WXF1,Q13822,A1X283 406 5.00e-02 1 3 1 0.333 1.000 HP:0008519 hp 1 Abnormality of the coccyx 1 A1X283 406 5.00e-02 1 3 1 0.333 1.000 HP:0008473 hp 1 Narrow anterio-posterior vertebral body diameter 1 A1X283 406 5.00e-02 1 3 1 0.333 1.000 HP:0040016 hp 1 Prominent coccyx 1 A1X283 406 5.00e-02 29 3 1 0.333 0.034 KEGG:00565 keg 1 Ether lipid metabolism 1 Q13822 406 5.00e-02 459 3 2 0.667 0.004 MI:hsa-miR-33b mi 1 MI:hsa-miR-33b 1 Q8WXF1,Q13822 406 5.00e-02 11 3 1 0.333 0.091 GO:0072673 BP 1 lamellipodium morphogenesis 1 Q13822 406 5.00e-02 1 3 1 0.333 1.000 OMIM:249420 omi 1 FRANK-TER HAAR SYNDROME; FTHS;;TER HAAR SYNDROME;;BORRONE DERMATOCARDIOSKELETAL SYNDROME;;MELNICK-NEEDLES SYNDROME, AUTOSOMAL RECESSIVE, FORMERLY 1 A1X283 406 5.00e-02 11 3 1 0.333 0.091 GO:0002102 CC 1 podosome 1 A1X283 407 1.12e-10 217 6 6 1.000 0.028 GO:0006260 BP 1 DNA replication 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.70e-10 12 6 4 0.667 0.333 REAC:176974 rea 1 Unwinding of DNA 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 2.12e-10 3 6 3 0.500 1.000 GO:0000811 CC 1 GINS complex 1 Q14691,Q9Y248,Q9BRT9 407 6.97e-10 25 6 4 0.667 0.160 GO:0006271 BP 1 DNA strand elongation involved in DNA replication 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 1.74e-09 119 6 5 0.833 0.042 GO:0006261 BP 1 DNA-dependent DNA replication 1 Q9BVW5,Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 1.98e-09 32 6 4 0.667 0.125 GO:0022616 BP 1 DNA strand elongation 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 2.12e-09 5 6 3 0.500 0.600 GO:0031261 CC 1 DNA replication preinitiation complex 1 Q14691,Q9Y248,Q9BRT9 407 7.43e-09 7 6 3 0.500 0.429 GO:0031298 CC 1 replication fork protection complex 1 Q9BVW5,Q9Y248,Q9BRT9 407 1.23e-08 32 6 4 0.667 0.125 REAC:69190 rea 1 DNA strand elongation 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 3.50e-08 11 6 3 0.500 0.273 GO:0043138 MF 1 3'-5' DNA helicase activity 1 Q14691,Q9Y248,Q9BRT9 407 1.02e-07 670 6 6 1.000 0.009 GO:0006259 BP 1 DNA metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.82e-07 21 6 3 0.500 0.143 GO:0033260 BP 1 nuclear DNA replication 1 Q9BVW5,Q14691,Q9Y248 407 4.39e-07 357 6 5 0.833 0.014 GO:0044454 CC 1 nuclear chromosome part 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 6.24e-07 383 6 5 0.833 0.013 GO:0000228 CC 1 nuclear chromosome 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 7.72e-07 29 6 3 0.500 0.103 GO:0044786 BP 1 cell cycle DNA replication 1 Q9BVW5,Q14691,Q9Y248 407 1.27e-06 99 6 4 0.667 0.040 REAC:69239 rea 1 Synthesis of DNA 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 1.68e-06 106 6 4 0.667 0.038 REAC:69306 rea 1 DNA Replication 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 2.08e-06 40 6 3 0.500 0.075 GO:0043596 CC 1 nuclear replication fork 1 Q9BVW5,Q9Y248,Q9BRT9 407 3.36e-06 126 6 4 0.667 0.032 REAC:69242 rea 1 S Phase 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 3.41e-06 47 6 3 0.500 0.064 GO:0003678 MF 1 DNA helicase activity 1 Q14691,Q9Y248,Q9BRT9 407 3.67e-06 4 6 2 0.333 0.500 GO:0000727 BP 1 double-strand break repair via break-induced replication 1 Q9Y248,Q9BRT9 407 4.33e-06 565 6 5 0.833 0.009 GO:0044427 CC 1 chromosomal part 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 5.83e-06 56 6 3 0.500 0.054 GO:0005657 CC 1 replication fork 1 Q9BVW5,Q9Y248,Q9BRT9 407 6.12e-06 5 6 2 0.333 0.400 GO:1902969 BP 1 mitotic DNA replication 1 Q14691,Q9Y248 407 6.29e-06 609 6 5 0.833 0.008 GO:0005694 CC 1 chromosome 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 1.30e-05 73 6 3 0.500 0.041 GO:0032993 CC 1 protein-DNA complex 1 Q14691,Q9Y248,Q9BRT9 407 4.74e-05 112 6 3 0.500 0.027 GO:0004386 MF 1 helicase activity 1 Q14691,Q9Y248,Q9BRT9 407 1.23e-04 154 6 3 0.500 0.019 GO:0006302 BP 1 double-strand break repair 1 Q9UNS1,Q9Y248,Q9BRT9 407 2.58e-04 592 6 4 0.667 0.007 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q9BVW5,Q9UNS1,Q9Y248,Q9BRT9 407 2.65e-04 30 6 2 0.333 0.067 GO:0006270 BP 1 DNA replication initiation 1 Q9Y248,Q9BRT9 407 3.00e-04 2529 6 6 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 5.17e-04 448 6 4 0.667 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 5.19e-04 2770 6 6 1.000 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 6.40e-04 2869 6 6 1.000 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 7.28e-04 2931 6 6 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 8.59e-04 3013 6 6 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.12e-03 547 6 4 0.667 0.007 REAC:1640170 rea 1 Cell Cycle 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 1.16e-03 3168 6 6 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.41e-03 1 6 1 0.167 1.000 GO:1902315 BP 1 nuclear cell cycle DNA replication initiation 1 Q9Y248 407 1.41e-03 1 6 1 0.167 1.000 GO:1902319 BP 1 DNA strand elongation involved in nuclear cell cycle DNA replication 1 Q14691 407 1.41e-03 1 6 1 0.167 1.000 GO:1902975 BP 1 mitotic DNA replication initiation 1 Q9Y248 407 1.41e-03 1 6 1 0.167 1.000 GO:1902292 BP 1 cell cycle DNA replication initiation 1 Q9Y248 407 1.41e-03 1 6 1 0.167 1.000 GO:1902983 BP 1 DNA strand elongation involved in mitotic DNA replication 1 Q14691 407 1.41e-03 1 6 1 0.167 1.000 GO:1902296 BP 1 DNA strand elongation involved in cell cycle DNA replication 1 Q14691 407 1.41e-03 1 6 1 0.167 1.000 GO:0043111 BP 1 replication fork arrest 1 Q9BVW5 407 1.54e-03 72 6 2 0.333 0.028 GO:0000725 BP 1 recombinational repair 1 Q9Y248,Q9BRT9 407 1.54e-03 72 6 2 0.333 0.028 GO:0000724 BP 1 double-strand break repair via homologous recombination 1 Q9Y248,Q9BRT9 407 1.64e-03 952 6 4 0.667 0.004 GO:0022402 BP 1 cell cycle process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248 407 1.84e-03 384 6 3 0.500 0.008 GO:0006281 BP 1 DNA repair 1 Q9UNS1,Q9Y248,Q9BRT9 407 1.88e-03 4 6 1 0.167 0.250 TF:M06899_0 tf 1 Factor: znf658b; motif: GGGGTGGGACGAGGTGGG; match class: 0 1 Q9BRX5 407 1.88e-03 4 6 1 0.167 0.250 TF:M06198_0 tf 1 Factor: ZNF76; motif: NKNGTKACTCCTGSAAMTG; match class: 0 1 Q14691 407 1.91e-03 3443 6 6 1.000 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.97e-03 1960 6 5 0.833 0.003 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 1.97e-03 1960 6 5 0.833 0.003 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 2.11e-03 3499 6 6 1.000 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.29e-03 4622 6 6 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.32e-03 3554 6 6 1.000 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.34e-03 3561 6 6 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.34e-03 3561 6 6 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.34e-03 3561 6 6 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.34e-03 3561 6 6 1.000 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.38e-03 3569 6 6 1.000 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.59e-03 3620 6 6 1.000 0.002 GO:0009058 BP 1 biosynthetic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.82e-03 2 6 1 0.167 0.500 GO:1904976 BP 1 cellular response to bleomycin 1 Q9UNS1 407 2.82e-03 2 6 1 0.167 0.500 GO:0072719 BP 1 cellular response to cisplatin 1 Q9UNS1 407 2.82e-03 2 6 1 0.167 0.500 GO:1904975 BP 1 response to bleomycin 1 Q9UNS1 407 2.82e-03 2 6 1 0.167 0.500 GO:0072718 BP 1 response to cisplatin 1 Q9UNS1 407 2.86e-03 3681 6 6 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 3.15e-03 1128 6 4 0.667 0.004 GO:0007049 BP 1 cell cycle 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248 407 3.30e-03 7 6 1 0.167 0.143 TF:M05856_0 tf 1 Factor: ZNF565; motif: KGGTGCGTAAGA; match class: 0 1 Q9UNS1 407 3.94e-03 74 6 2 0.333 0.027 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 Q9BVW5,Q9UNS1 407 4.15e-03 1212 6 4 0.667 0.003 GO:0033554 BP 1 cellular response to stress 1 Q9BVW5,Q9UNS1,Q9Y248,Q9BRT9 407 4.24e-03 9 6 1 0.167 0.111 TF:M05423_0 tf 1 Factor: RREB-1; motif: NGTGGCRGGTAAACGC; match class: 0 1 Q9Y248 407 4.36e-03 3948 6 6 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 4.49e-03 521 6 3 0.500 0.006 GO:0044451 CC 1 nucleoplasm part 1 Q14691,Q9Y248,Q9BRT9 407 5.01e-03 239 6 2 0.333 0.008 TF:M06564_0 tf 1 Factor: ZNF578; motif: KGGACGKGAAAA; match class: 0 1 Q9BVW5,Q9BRT9 407 5.34e-03 553 6 3 0.500 0.005 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 Q14691,Q9Y248,Q9BRT9 407 6.44e-03 590 6 3 0.500 0.005 GO:0016462 MF 1 pyrophosphatase activity 1 Q14691,Q9Y248,Q9BRT9 407 6.50e-03 592 6 3 0.500 0.005 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 Q14691,Q9Y248,Q9BRT9 407 6.50e-03 592 6 3 0.500 0.005 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Q14691,Q9Y248,Q9BRT9 407 6.91e-03 4264 6 6 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 7.06e-03 5 6 1 0.167 0.200 GO:0072711 BP 1 cellular response to hydroxyurea 1 Q9UNS1 407 7.06e-03 5 6 1 0.167 0.200 GO:0048478 BP 1 replication fork protection 1 Q9BVW5 407 7.06e-03 5 6 1 0.167 0.200 GO:0072710 BP 1 response to hydroxyurea 1 Q9UNS1 407 7.33e-03 5611 6 6 1.000 0.001 TF:M07286_1 tf 1 Factor: FOXO1A; motif: TTGTTTWN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 7.51e-03 160 6 2 0.333 0.013 GO:0006310 BP 1 DNA recombination 1 Q9Y248,Q9BRT9 407 7.74e-03 104 6 2 0.333 0.019 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q9BVW5,Q9UNS1 407 8.15e-03 3587 6 5 0.833 0.001 TF:M01216_1 tf 1 Factor: FOXO1; motif: NWAAACAAN; match class: 1 1 Q9BVW5,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 8.64e-03 110 6 2 0.333 0.018 REAC:5693538 rea 1 Homology Directed Repair 1 Q9BVW5,Q9UNS1 407 8.70e-03 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 8.78e-03 657 6 3 0.500 0.005 GO:1903047 BP 1 mitotic cell cycle process 1 Q9BVW5,Q14691,Q9Y248 407 8.81e-03 3647 6 5 0.833 0.001 TF:M00380_1 tf 1 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC; match class: 1 1 Q9BVW5,Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 8.93e-03 19 6 1 0.167 0.053 TF:M06749_0 tf 1 Factor: ZNF222; motif: NCGTAWTTCCGA; match class: 0 1 Q9BVW5 407 1.06e-02 5967 6 6 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.13e-02 8 6 1 0.167 0.125 GO:2000781 BP 1 positive regulation of double-strand break repair 1 Q9UNS1 407 1.15e-02 721 6 3 0.500 0.004 GO:0000278 BP 1 mitotic cell cycle 1 Q9BVW5,Q14691,Q9Y248 407 1.15e-02 3864 6 5 0.833 0.001 TF:M03571_1 tf 1 Factor: C/EBPdelta; motif: TTGCNNMAN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 1.16e-02 324 6 2 0.333 0.006 MI:hsa-miR-100* mi 1 MI:hsa-miR-100* 1 Q9BVW5,Q9Y248 407 1.18e-02 201 6 2 0.333 0.010 GO:0000790 CC 1 nuclear chromatin 1 Q9BVW5,Q9UNS1 407 1.22e-02 26 6 1 0.167 0.038 TF:M02268_1 tf 1 Factor: INSM1; motif: TGYCAGGGGGCR; match class: 1 1 Q9BVW5 407 1.22e-02 26 6 1 0.167 0.038 TF:M06300_0 tf 1 Factor: ZNF181; motif: NTGGCMTGTTGM; match class: 0 1 Q9Y248 407 1.27e-02 9 6 1 0.167 0.111 GO:0033262 BP 1 regulation of nuclear cell cycle DNA replication 1 Q9BVW5 407 1.28e-02 388 6 2 0.333 0.005 TF:M00955_1 tf 1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 1 1 Q9UNS1,Q9BRX5 407 1.33e-02 137 6 2 0.333 0.015 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 Q9BVW5,Q9UNS1 407 1.46e-02 4064 6 5 0.833 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRX5 407 1.49e-02 4080 6 5 0.833 0.001 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 Q9BVW5,Q14691,Q9Y248,Q9BRT9,Q9BRX5 407 1.55e-02 11 6 1 0.167 0.091 GO:0031573 BP 1 intra-S DNA damage checkpoint 1 Q9BVW5 407 1.58e-02 381 6 2 0.333 0.005 MI:hsa-miR-384 mi 1 MI:hsa-miR-384 1 Q9UNS1,Q9BRX5 407 1.61e-02 236 6 2 0.333 0.008 GO:0051052 BP 1 regulation of DNA metabolic process 1 Q9BVW5,Q9UNS1 407 1.61e-02 3521 6 5 0.833 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 1.71e-02 4204 6 5 0.833 0.001 TF:M01862_0 tf 1 Factor: ATF-2; motif: NNNTGACGTNAN; match class: 0 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 1.71e-02 1309 6 3 0.500 0.002 TF:M04633_1 tf 1 Factor: TCF-4; motif: NCTTTGAWNN; match class: 1 1 Q14691,Q9UNS1,Q9Y248 407 1.73e-02 37 6 1 0.167 0.027 TF:M04061_0 tf 1 Factor: Pax-2; motif: SGTCACGCWTSANTGMNY; match class: 0 1 Q9BRT9 407 1.73e-02 37 6 1 0.167 0.027 TF:M00056_0 tf 1 Factor: myogenin; motif: CRSCTGTTBNNTTTGGCACGSNGCCARCH; match class: 0 1 Q9BRX5 407 1.78e-02 4990 6 6 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 1.90e-02 1361 6 3 0.500 0.002 TF:M01661_0 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 0 1 Q9BVW5,Q9UNS1,Q9BRX5 407 1.95e-02 1374 6 3 0.500 0.002 TF:M00478_0 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 0 1 Q9BVW5,Q9Y248,Q9BRX5 407 2.00e-02 490 6 2 0.333 0.004 TF:M06081_0 tf 1 Factor: ZNF99; motif: TAGCTGRACA; match class: 0 1 Q14691,Q9BRX5 407 2.02e-02 2674 6 4 0.667 0.001 TF:M07308_0 tf 1 Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 0 1 Q9BVW5,Q9Y248,Q9BRT9,Q9BRX5 407 2.11e-02 2705 6 4 0.667 0.001 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q9BVW5,Q14691,Q9Y248,Q9BRT9 407 2.11e-02 15 6 1 0.167 0.067 GO:2000104 BP 1 negative regulation of DNA-dependent DNA replication 1 Q9BVW5 407 2.25e-02 16 6 1 0.167 0.062 GO:0000076 BP 1 DNA replication checkpoint 1 Q9BVW5 407 2.33e-02 50 6 1 0.167 0.020 TF:M06529_0 tf 1 Factor: ZNF596; motif: NGGTCGGGAAAA; match class: 0 1 Q9BVW5 407 2.46e-02 294 6 2 0.333 0.007 GO:0000785 CC 1 chromatin 1 Q9BVW5,Q9UNS1 407 2.52e-02 54 6 1 0.167 0.019 TF:M05606_0 tf 1 Factor: ZNF691; motif: NAGGCCAGCCGC; match class: 0 1 Q9Y248 407 2.57e-02 559 6 2 0.333 0.004 TF:M05709_0 tf 1 Factor: znf136; motif: NGRWYGWAGAGA; match class: 0 1 Q14691,Q9Y248 407 2.60e-02 4605 6 5 0.833 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 2.61e-02 5319 6 6 1.000 0.001 GO:0043170 BP 1 macromolecule metabolic process 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 2.61e-02 496 6 2 0.333 0.004 MI:hsa-miR-515-5p mi 1 MI:hsa-miR-515-5p 1 Q9UNS1,Q9Y248 407 2.75e-02 59 6 1 0.167 0.017 TF:M00244_0 tf 1 Factor: NGFI-C; motif: WTGCGTGGGYGG; match class: 0 1 Q9Y248 407 2.75e-02 59 6 1 0.167 0.017 TF:M01657_1 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 1 1 Q9UNS1 407 2.75e-02 4665 6 5 0.833 0.001 TF:M00117_1 tf 1 Factor: C/EBPbeta; motif: NKNTTGCNYAAYNN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9BRT9,Q9BRX5 407 2.79e-02 3415 6 5 0.833 0.001 GO:0032991 CC 1 macromolecular complex 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 2.84e-02 2941 6 4 0.667 0.001 TF:M00737_0 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 0 1 Q14691,Q9UNS1,Q9Y248,Q9BRX5 407 2.88e-02 2952 6 4 0.667 0.001 TF:M00454_0 tf 1 Factor: MRF2; motif: AWSCACAATACNVA; match class: 0 1 Q9BVW5,Q9UNS1,Q9BRT9,Q9BRX5 407 2.93e-02 528 6 2 0.333 0.004 MI:hsa-miR-29a mi 1 MI:hsa-miR-29a 1 Q9UNS1,Q9Y248 407 2.98e-02 7087 6 6 1.000 0.001 TF:M07419_1 tf 1 Factor: FOXP3; motif: NNNVAAACANWD; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 3.03e-02 537 6 2 0.333 0.004 MI:hsa-miR-29b mi 1 MI:hsa-miR-29b 1 Q9UNS1,Q9Y248 407 3.05e-02 7114 6 6 1.000 0.001 TF:M07056_1 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 3.05e-02 7114 6 6 1.000 0.001 TF:M02114_1 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 3.10e-02 7134 6 6 1.000 0.001 TF:M01216_0 tf 1 Factor: FOXO1; motif: NWAAACAAN; match class: 0 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 3.10e-02 2071 6 4 0.667 0.002 GO:0006950 BP 1 response to stress 1 Q9BVW5,Q9UNS1,Q9Y248,Q9BRT9 407 3.12e-02 67 6 1 0.167 0.015 TF:M07372_1 tf 1 Factor: AML2; motif: TGTGGTNNN; match class: 1 1 Q9BVW5 407 3.16e-02 68 6 1 0.167 0.015 TF:M06370_0 tf 1 Factor: ZNF585A; motif: ACTWTCKAWAGG; match class: 0 1 Q9BRT9 407 3.16e-02 68 6 1 0.167 0.015 TF:M05727_0 tf 1 Factor: ZNF674; motif: NGTTMAAAAAWA; match class: 0 1 Q9UNS1 407 3.20e-02 553 6 2 0.333 0.004 MI:hsa-miR-29c mi 1 MI:hsa-miR-29c 1 Q9UNS1,Q9Y248 407 3.25e-02 634 6 2 0.333 0.003 TF:M00413_1 tf 1 Factor: AREB6; motif: WNWCACCTGWNN; match class: 1 1 Q9Y248,Q9BRT9 407 3.26e-02 70 6 1 0.167 0.014 TF:M06397_0 tf 1 Factor: ZNF761; motif: NGGTYGGGCAWA; match class: 0 1 Q9BVW5 407 3.31e-02 563 6 2 0.333 0.004 MI:hsa-miR-520a-5p mi 1 MI:hsa-miR-520a-5p 1 Q9UNS1,Q9Y248 407 3.40e-02 4885 6 5 0.833 0.001 TF:M00912_1 tf 1 Factor: C/EBP; motif: NTTRCNNAANNN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9BRT9,Q9BRX5 407 3.40e-02 3093 6 4 0.667 0.001 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 Q9BVW5,Q14691,Q9Y248,Q9BRT9 407 3.49e-02 1703 6 3 0.500 0.002 TF:M00940_0 tf 1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 0 1 Q14691,Q9UNS1,Q9Y248 407 3.77e-02 1753 6 3 0.500 0.002 TF:M03827_1 tf 1 Factor: HNF-3alpha; motif: RYAAACAN; match class: 1 1 Q9BVW5,Q14691,Q9BRX5 407 3.79e-02 27 6 1 0.167 0.037 GO:0008156 BP 1 negative regulation of DNA replication 1 Q9BVW5 407 3.79e-02 27 6 1 0.167 0.037 GO:0045005 BP 1 DNA-dependent DNA replication maintenance of fidelity 1 Q9BVW5 407 3.99e-02 86 6 1 0.167 0.012 TF:M06108_0 tf 1 Factor: ZNF43; motif: NCTKGTTGGTGM; match class: 0 1 Q9UNS1 407 4.03e-02 87 6 1 0.167 0.011 TF:M06603_0 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 0 1 Q9Y248 407 4.06e-02 1802 6 3 0.500 0.002 TF:M03839_0 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 0 1 Q9BVW5,Q9UNS1,Q9Y248 407 4.21e-02 91 6 1 0.167 0.011 TF:M05748_0 tf 1 Factor: ZNF697; motif: NTGGGCRTCGGC; match class: 0 1 Q9BVW5 407 4.30e-02 5147 6 5 0.833 0.001 TF:M00630_0 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 0 1 Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 4.32e-02 5787 6 6 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 4.35e-02 31 6 1 0.167 0.032 GO:2000779 BP 1 regulation of double-strand break repair 1 Q9UNS1 407 4.36e-02 5164 6 5 0.833 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9 407 4.59e-02 3370 6 4 0.667 0.001 TF:M00192_0 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 0 1 Q14691,Q9UNS1,Q9Y248,Q9BRX5 407 4.60e-02 1889 6 3 0.500 0.002 TF:M00775_0 tf 1 Factor: NF-Y; motif: NNNNRRCCAATSR; match class: 0 1 Q14691,Q9BRT9,Q9BRX5 407 4.67e-02 101 6 1 0.167 0.010 TF:M05833_0 tf 1 Factor: ZNF572; motif: NNKGRCTGTAGM; match class: 0 1 Q9BRT9 407 4.74e-02 5877 6 6 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRT9,Q9BRX5 407 4.80e-02 1920 6 3 0.500 0.002 TF:M00736_0 tf 1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 0 1 Q9UNS1,Q9Y248,Q9BRX5 407 4.83e-02 5282 6 5 0.833 0.001 TF:M00913_0 tf 1 Factor: MYB; motif: NAACNGNCN; match class: 0 1 Q9BVW5,Q14691,Q9UNS1,Q9Y248,Q9BRX5 407 4.86e-02 788 6 2 0.333 0.003 TF:M00431_1 tf 1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 1 Q14691,Q9BRX5 407 4.89e-02 106 6 1 0.167 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 Q14691 407 4.91e-02 35 6 1 0.167 0.029 GO:0045739 BP 1 positive regulation of DNA repair 1 Q9UNS1 407 4.91e-02 35 6 1 0.167 0.029 GO:0090329 BP 1 regulation of DNA-dependent DNA replication 1 Q9BVW5 407 4.99e-02 799 6 2 0.333 0.003 TF:M00209_0 tf 1 Factor: NF-Y; motif: NCTGATTGGYTASY; match class: 0 1 Q14691,Q9BRT9 407 5.00e-02 272 6 2 0.333 0.007 REAC:73894 rea 1 DNA Repair 1 Q9BVW5,Q9UNS1 407 5.00e-02 425 6 2 0.333 0.005 GO:0044770 BP 1 cell cycle phase transition 1 Q9BVW5,Q9UNS1 407 5.00e-02 4 6 4 0.667 1.000 CORUM:678 cor 1 GINS complex 1 Q14691,Q9Y248,Q9BRT9,Q9BRX5 408 1.55e-03 292 3 2 0.667 0.007 TF:M05837_0 tf 1 Factor: ZFP2; motif: NCCWCGGGRATA; match class: 0 1 Q9P275,Q7Z2T5 408 2.72e-03 1778 3 3 1.000 0.002 TF:M00513_0 tf 1 Factor: ATF3; motif: CBCTGACGTCANCS; match class: 0 1 Q9H6R0,Q9P275,Q7Z2T5 408 3.06e-03 13 3 1 0.333 0.077 TF:M06811_0 tf 1 Factor: ZNF528; motif: KGTTAMGGCCGM; match class: 0 1 Q9P275 408 3.77e-03 16 3 1 0.333 0.062 TF:M06535_0 tf 1 Factor: ZNF555; motif: KGGGGCTGCCGN; match class: 0 1 Q9P275 408 4.64e-03 447 3 2 0.667 0.004 MI:hsa-miR-587 mi 1 MI:hsa-miR-587 1 Q9P275,Q7Z2T5 408 4.93e-03 461 3 2 0.667 0.004 MI:hsa-miR-589 mi 1 MI:hsa-miR-589 1 Q9P275,Q7Z2T5 408 4.94e-03 21 3 1 0.333 0.048 TF:M00665_1 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 1 Q9P275 408 6.59e-03 28 3 1 0.333 0.036 TF:M05677_0 tf 1 Factor: ZNF816A; motif: KGGGAAAAMGGM; match class: 0 1 Q9H6R0 408 6.59e-03 28 3 1 0.333 0.036 TF:M07367_1 tf 1 Factor: Slug; motif: SSSNNNKCACCTGN; match class: 1 1 Q9P275 408 7.99e-03 34 3 1 0.333 0.029 TF:M03928_1 tf 1 Factor: ZBTB7B; motif: NCGACCACCGAA; match class: 1 1 Q9H6R0 408 8.34e-03 684 3 2 0.667 0.003 TF:M00011_0 tf 1 Factor: Evi-1; motif: ACAAGATAA; match class: 0 1 Q9P275,Q7Z2T5 408 8.37e-03 685 3 2 0.667 0.003 TF:M00665_0 tf 1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 0 1 Q9P275,Q7Z2T5 408 8.37e-03 603 3 2 0.667 0.003 MI:mmu-miR-466f-5p mi 1 MI:mmu-miR-466f-5p 1 Q9H6R0,Q9P275 408 9.16e-03 39 3 1 0.333 0.026 TF:M05799_0 tf 1 Factor: ZNF605; motif: NTTWTAATACGA; match class: 0 1 Q9P275 408 1.29e-02 55 3 1 0.333 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q7Z2T5 408 1.45e-02 62 3 1 0.333 0.016 TF:M05714_0 tf 1 Factor: Evi-1; motif: KGGTCMMAACTN; match class: 0 1 Q9P275 408 1.52e-02 65 3 1 0.333 0.015 TF:M03927_1 tf 1 Factor: ZBTB7A; motif: NGCGACCACCNN; match class: 1 1 Q9H6R0 408 1.55e-02 66 3 1 0.333 0.015 TF:M04251_0 tf 1 Factor: FOXJ3; motif: GTAAACATAAACA; match class: 0 1 Q7Z2T5 408 1.78e-02 76 3 1 0.333 0.013 TF:M04176_0 tf 1 Factor: MAX; motif: NNCACGTGNN; match class: 0 1 Q9P275 408 1.90e-02 1042 3 2 0.667 0.002 TF:M00672_0 tf 1 Factor: TEF; motif: ATGTTWAYATAA; match class: 0 1 Q9H6R0,Q9P275 408 1.91e-02 1046 3 2 0.667 0.002 TF:M00262_0 tf 1 Factor: Staf; motif: NTTWCCCANMATGCAYYRCGNY; match class: 0 1 Q9H6R0,Q7Z2T5 408 2.15e-02 1110 3 2 0.667 0.002 TF:M00916_1 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 1 1 Q9P275,Q7Z2T5 408 2.15e-02 92 3 1 0.333 0.011 TF:M06359_0 tf 1 Factor: ZNF562; motif: TAGGGGGAGGA; match class: 0 1 Q7Z2T5 408 2.31e-02 1153 3 2 0.667 0.002 TF:M01716_0 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 0 1 Q9H6R0,Q7Z2T5 408 2.34e-02 100 3 1 0.333 0.010 TF:M03967_0 tf 1 Factor: ELF3; motif: WACCCGGAAGTAN; match class: 0 1 Q9P275 408 2.43e-02 3685 3 3 1.000 0.001 TF:M03573_0 tf 1 Factor: FKHL5; motif: ATGTTTAT; match class: 0 1 Q9H6R0,Q9P275,Q7Z2T5 408 2.45e-02 105 3 1 0.333 0.010 TF:M00954_0 tf 1 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN; match class: 0 1 Q9H6R0 408 2.49e-02 1197 3 2 0.667 0.002 TF:M07319_1 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 1 1 Q9H6R0,Q7Z2T5 408 2.57e-02 110 3 1 0.333 0.009 TF:M04058_0 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 0 1 Q7Z2T5 408 2.62e-02 112 3 1 0.333 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 Q7Z2T5 408 2.83e-02 3879 3 3 1.000 0.001 TF:M03873_0 tf 1 Factor: HOXA10; motif: ANTTTATG; match class: 0 1 Q9H6R0,Q9P275,Q7Z2T5 408 2.86e-02 2 3 1 0.333 0.500 GO:0002940 BP 1 tRNA N2-guanine methylation 1 Q7Z2T5 408 2.87e-02 123 3 1 0.333 0.008 TF:M05313_1 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 1 1 Q9H6R0 408 2.89e-02 124 3 1 0.333 0.008 TF:M05358_0 tf 1 Factor: RLF; motif: GCATCRWCATT; match class: 0 1 Q9P275 408 2.94e-02 126 3 1 0.333 0.008 TF:M03968_0 tf 1 Factor: ELF4; motif: AACCCGGAAGTR; match class: 0 1 Q9P275 408 3.10e-02 133 3 1 0.333 0.008 TF:M06387_0 tf 1 Factor: ZSCAN2; motif: NGGGWAAAACGC; match class: 0 1 Q9H6R0 408 3.20e-02 1365 3 2 0.667 0.001 TF:M03544_1 tf 1 Factor: CREB1; motif: NNNNACGTCANN; match class: 1 1 Q9P275,Q7Z2T5 408 3.30e-02 1387 3 2 0.667 0.001 TF:M00917_1 tf 1 Factor: CREB; motif: CNNTGACGTMA; match class: 1 1 Q9P275,Q7Z2T5 408 3.43e-02 147 3 1 0.333 0.007 TF:M05303_0 tf 1 Factor: ZNF536; motif: NCWGSTGCTA; match class: 0 1 Q9P275 408 3.60e-02 4204 3 3 1.000 0.001 TF:M01862_0 tf 1 Factor: ATF-2; motif: NNNTGACGTNAN; match class: 0 1 Q9H6R0,Q9P275,Q7Z2T5 408 3.72e-02 1476 3 2 0.667 0.001 TF:M02110_1 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 1 1 Q9P275,Q7Z2T5 408 3.86e-02 166 3 1 0.333 0.006 TF:M06096_0 tf 1 Factor: ZNF682; motif: KGRGGCGGCTGW; match class: 0 1 Q9P275 408 3.98e-02 1529 3 2 0.667 0.001 TF:M07384_0 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 0 1 Q9H6R0,Q9P275 408 4.11e-02 177 3 1 0.333 0.006 TF:M00694_0 tf 1 Factor: E4F1; motif: SYTACGTCAC; match class: 0 1 Q9P275 408 4.17e-02 1567 3 2 0.667 0.001 TF:M07361_0 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 0 1 Q9P275,Q7Z2T5 408 4.21e-02 181 3 1 0.333 0.006 TF:M03966_0 tf 1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 0 1 Q9P275 408 4.23e-02 182 3 1 0.333 0.005 TF:M04192_0 tf 1 Factor: TFAP4; motif: AWCAGCTGWT; match class: 0 1 Q9H6R0 408 4.29e-02 3 3 1 0.333 0.333 GO:0004809 MF 1 tRNA (guanine-N2-)-methyltransferase activity 1 Q7Z2T5 408 4.30e-02 185 3 1 0.333 0.005 TF:M06608_0 tf 1 Factor: ZNF486; motif: NGRGGCTTGGGA; match class: 0 1 Q9H6R0 408 4.37e-02 188 3 1 0.333 0.005 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 Q9P275 408 4.37e-02 188 3 1 0.333 0.005 TF:M03877_1 tf 1 Factor: MASH-1; motif: YMMCACCTGCY; match class: 1 1 Q9P275 408 4.50e-02 194 3 1 0.333 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 Q9H6R0 408 4.53e-02 195 3 1 0.333 0.005 TF:M06390_0 tf 1 Factor: ZNF227; motif: RTTCKGAGATN; match class: 0 1 Q9P275 408 4.81e-02 1688 3 2 0.667 0.001 TF:M07426_0 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 0 1 Q9P275,Q7Z2T5 408 4.82e-02 208 3 1 0.333 0.005 TF:M06154_0 tf 1 Factor: ZNF132; motif: NTTRGAAATGTTYM; match class: 0 1 Q7Z2T5 408 4.84e-02 1694 3 2 0.667 0.001 TF:M03886_0 tf 1 Factor: Sox2; motif: NNCCWTTGTTNTKN; match class: 0 1 Q9H6R0,Q7Z2T5 408 4.91e-02 1706 3 2 0.667 0.001 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 Q9P275,Q7Z2T5 408 5.00e-02 1118 3 3 1.000 0.003 GO:0044822 MF 1 poly(A) RNA binding 1 Q9H6R0,Q9P275,Q7Z2T5 409 6.05e-03 840 2 2 1.000 0.002 HPA:041020_03 hpa 1 spleen; cells in white pulp[Uncertain,High] 1 P13796,Q9UMR2 409 1.28e-02 1220 2 2 1.000 0.002 HPA:046010_03 hpa 1 tonsil; germinal center cells[Uncertain,High] 1 P13796,Q9UMR2 409 1.35e-02 1254 2 2 1.000 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 P13796,Q9UMR2 409 1.47e-02 1310 2 2 1.000 0.002 HPA:046020_03 hpa 1 tonsil; non-germinal center cells[Uncertain,High] 1 P13796,Q9UMR2 409 1.82e-02 4 2 1 0.500 0.250 GO:0071803 BP 1 positive regulation of podosome assembly 1 P13796 409 3.53e-02 12 2 1 0.500 0.083 TF:M06148_0 tf 1 Factor: ZNF41; motif: NAKTAAGAGARA; match class: 0 1 Q9UMR2 409 3.64e-02 8 2 1 0.500 0.125 GO:0051639 BP 1 actin filament network formation 1 P13796 409 4.09e-02 9 2 1 0.500 0.111 GO:0071801 BP 1 regulation of podosome assembly 1 P13796 409 4.09e-02 9 2 1 0.500 0.111 GO:0051764 BP 1 actin crosslink formation 1 P13796 409 4.12e-02 14 2 1 0.500 0.071 TF:M06378_0 tf 1 Factor: ZNF562; motif: NKGGTCATAAGC; match class: 0 1 P13796 409 4.35e-02 246 2 1 0.500 0.004 MI:hsa-miR-454* mi 1 MI:hsa-miR-454* 1 Q9UMR2 409 5.00e-02 17 2 1 0.500 0.059 TF:M04519_0 tf 1 Factor: E2F-4; motif: TTTGGCGCCAAA; match class: 0 1 P13796 409 5.00e-02 11 2 1 0.500 0.091 GO:0002102 CC 1 podosome 1 P13796 410 1.19e-02 9 2 1 0.500 0.111 REAC:418890 rea 1 Role of second messengers in netrin-1 signaling 1 Q00169 410 1.92e-02 5 2 1 0.500 0.200 GO:0008526 MF 1 phosphatidylinositol transporter activity 1 Q00169 410 2.31e-02 6 2 1 0.500 0.167 GO:1901611 MF 1 phosphatidylglycerol binding 1 Q00169 410 2.69e-02 7 2 1 0.500 0.143 GO:0008525 MF 1 phosphatidylcholine transporter activity 1 Q00169 410 5.00e-02 2 2 1 0.500 0.500 TF:M05848_0 tf 1 Factor: ZNF615; motif: NGKTAMAAGCGA; match class: 0 1 Q00169 410 5.00e-02 13 2 1 0.500 0.077 GO:0031210 MF 1 phosphatidylcholine binding 1 Q00169 410 5.00e-02 13 2 1 0.500 0.077 GO:0050997 MF 1 quaternary ammonium group binding 1 Q00169 410 5.00e-02 38 2 1 0.500 0.026 REAC:373752 rea 1 Netrin-1 signaling 1 Q00169 411 1.09e-03 420 2 2 1.000 0.005 TF:M05752_0 tf 1 Factor: ZNF57; motif: NCGGGGTGGKSA; match class: 0 1 Q8TB22,O95299 411 6.56e-03 1031 2 2 1.000 0.002 TF:M00260_0 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 0 1 Q8TB22,O95299 411 1.03e-02 66 2 1 0.500 0.015 TF:M03907_1 tf 1 Factor: HINFP; motif: CNRCGTCCGCNN; match class: 1 1 O95299 411 1.14e-02 73 2 1 0.500 0.014 TF:M05974_0 tf 1 Factor: ZNF701; motif: KGGGAATGCAGM; match class: 0 1 O95299 411 1.16e-02 9 2 1 0.500 0.111 CORUM:2919 cor 1 Respiratory chain complex I (gamma subunit) mitochondrial 1 O95299 411 1.42e-02 11 2 1 0.500 0.091 CORUM:2948 cor 1 Respiratory chain complex I (incomplete intermediate), mitochondrial 1 O95299 411 1.50e-02 96 2 1 0.500 0.010 TF:M00929_1 tf 1 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN; match class: 1 1 Q8TB22 411 1.71e-02 109 2 1 0.500 0.009 TF:M07098_1 tf 1 Factor: HNF-4gamma; motif: NNRGNNCAAAGKYCA; match class: 1 1 Q8TB22 411 1.80e-02 1706 2 2 1.000 0.001 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 Q8TB22,O95299 411 2.15e-02 1868 2 2 1.000 0.001 TF:M01996_1 tf 1 Factor: AR; motif: GNNCNNNNTGTTCTN; match class: 1 1 Q8TB22,O95299 411 2.33e-02 51 2 1 0.500 0.020 REAC:6799198 rea 1 Complex I biogenesis 1 O95299 411 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 Q8TB22 411 2.54e-02 163 2 1 0.500 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 Q8TB22 411 2.59e-02 35 2 1 0.500 0.029 HP:0001404 hp 1 Hepatocellular necrosis 1 O95299 411 2.65e-02 170 2 1 0.500 0.006 TF:M02021_1 tf 1 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG; match class: 1 1 Q8TB22 411 2.78e-02 178 2 1 0.500 0.006 TF:M00411_1 tf 1 Factor: HNF4alpha1; motif: NRGGNCAAAGGTCAN; match class: 1 1 Q8TB22 411 2.87e-02 184 2 1 0.500 0.005 TF:M05438_0 tf 1 Factor: Osx; motif: WGGGCGGGTS; match class: 0 1 Q8TB22 411 2.87e-02 184 2 1 0.500 0.005 TF:M05417_0 tf 1 Factor: ZNF641; motif: NAGGGGKGGGGN; match class: 0 1 O95299 411 2.87e-02 184 2 1 0.500 0.005 TF:M00998_1 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 1 1 O95299 411 2.88e-02 39 2 1 0.500 0.026 HP:0002605 hp 1 Hepatic necrosis 1 O95299 411 3.24e-02 208 2 1 0.500 0.005 TF:M06849_0 tf 1 Factor: ZNF528; motif: NSTCCGGAAGA; match class: 0 1 Q8TB22 411 3.43e-02 220 2 1 0.500 0.005 TF:M00134_1 tf 1 Factor: HNF4; motif: NNNRGGNCAAAGKTCANNN; match class: 1 1 Q8TB22 411 3.46e-02 2367 2 2 1.000 0.001 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q8TB22,O95299 411 3.51e-02 2385 2 2 1.000 0.001 TF:M03828_0 tf 1 Factor: HNF-4; motif: NNNNNNNGNNCAAAGKYCAN; match class: 0 1 Q8TB22,O95299 411 3.60e-02 231 2 1 0.500 0.004 TF:M07310_0 tf 1 Factor: Sp5; motif: ACCSCGCCKCCSS; match class: 0 1 O95299 411 3.77e-02 242 2 1 0.500 0.004 TF:M05961_1 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 1 1 Q8TB22 411 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 Q8TB22,O95299 411 3.80e-02 244 2 1 0.500 0.004 TF:M00514_1 tf 1 Factor: ATF4; motif: CVTGACGYMABG; match class: 1 1 O95299 411 3.86e-02 248 2 1 0.500 0.004 TF:M03828_1 tf 1 Factor: HNF-4; motif: NNNNNNNGNNCAAAGKYCAN; match class: 1 1 Q8TB22 411 4.03e-02 259 2 1 0.500 0.004 TF:M07350_1 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 1 1 Q8TB22 411 4.10e-02 90 2 1 0.500 0.011 REAC:611105 rea 1 Respiratory electron transport 1 O95299 411 4.12e-02 296 2 2 1.000 0.007 MI:hsa-miR-194* mi 1 MI:hsa-miR-194* 1 Q8TB22,O95299 411 4.25e-02 2625 2 2 1.000 0.001 TF:M00706_1 tf 1 Factor: TFII-I; motif: RGAGGKAGG; match class: 1 1 Q8TB22,O95299 411 4.37e-02 281 2 1 0.500 0.004 TF:M03855_0 tf 1 Factor: Tbx5:csx; motif: YMTYCTSWCACYTGN; match class: 0 1 Q8TB22 411 4.42e-02 60 2 1 0.500 0.017 HP:0030085 hp 1 Abnormal CSF lactate level 1 O95299 411 4.42e-02 60 2 1 0.500 0.017 HP:0002490 hp 1 Increased CSF lactate 1 O95299 411 4.43e-02 285 2 1 0.500 0.004 TF:M00257_0 tf 1 Factor: RREB-1; motif: CCCCAAACMMCCCC; match class: 0 1 O95299 411 4.46e-02 2689 2 2 1.000 0.001 TF:M06191_1 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 1 1 Q8TB22,O95299 411 4.46e-02 2689 2 2 1.000 0.001 TF:M06190_1 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 1 1 Q8TB22,O95299 411 4.54e-02 292 2 1 0.500 0.003 TF:M00687_1 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 1 Q8TB22 411 4.78e-02 65 2 1 0.500 0.015 HP:0007305 hp 1 CNS demyelination 1 O95299 411 5.00e-02 322 2 1 0.500 0.003 TF:M02272_0 tf 1 Factor: RXR:RAR; motif: RGKTCANNNRGAGGTCA; match class: 0 1 Q8TB22 411 5.00e-02 68 2 1 0.500 0.015 HP:0001427 hp 1 Mitochondrial inheritance 1 O95299 411 5.00e-02 326 2 2 1.000 0.006 MI:hsa-miR-182* mi 1 MI:hsa-miR-182* 1 Q8TB22,O95299 411 5.00e-02 110 2 1 0.500 0.009 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 O95299 411 5.00e-02 39 2 1 0.500 0.026 CORUM:178 cor 1 Respiratory chain complex I (holoenzyme), mitochondrial 1 O95299 411 5.00e-02 3 2 1 0.500 0.333 GO:0071554 BP 1 cell wall organization or biogenesis 1 Q8TB22 412 1.33e-02 77 2 1 0.500 0.013 GO:0019079 BP 1 viral genome replication 1 Q9NZI7 412 2.60e-02 151 2 1 0.500 0.007 GO:0003714 MF 1 transcription corepressor activity 1 Q9NZI7 412 5.00e-02 297 2 2 1.000 0.007 TF:M00999_0 tf 1 Factor: AIRE; motif: WTNNNWNNTGGWWNNNWNGGNNWNWN; match class: 0 1 Q9NZI7,Q8N6D5 413 1.27e-04 64 2 2 1.000 0.031 GO:0036459 MF 1 thiol-dependent ubiquitinyl hydrolase activity 1 Q15040,O00303 413 1.27e-04 64 2 2 1.000 0.031 GO:0004843 MF 1 thiol-dependent ubiquitin-specific protease activity 1 Q15040,O00303 413 1.39e-04 67 2 2 1.000 0.030 GO:0101005 MF 1 ubiquitinyl hydrolase activity 1 Q15040,O00303 413 1.75e-04 75 2 2 1.000 0.027 GO:0019783 MF 1 ubiquitin-like protein-specific protease activity 1 Q15040,O00303 413 2.30e-04 86 2 2 1.000 0.023 GO:0016579 BP 1 protein deubiquitination 1 Q15040,O00303 413 3.31e-04 103 2 2 1.000 0.019 GO:0070646 BP 1 protein modification by small protein removal 1 Q15040,O00303 413 5.37e-04 131 2 2 1.000 0.015 GO:0008234 MF 1 cysteine-type peptidase activity 1 Q15040,O00303 413 1.45e-03 2 2 1 0.500 0.500 GO:0071541 CC 1 eukaryotic translation initiation factor 3 complex, eIF3m 1 O00303 413 4.00e-03 357 2 2 1.000 0.006 GO:0070011 MF 1 peptidase activity, acting on L-amino acid peptides 1 Q15040,O00303 413 4.21e-03 366 2 2 1.000 0.005 GO:0008233 MF 1 peptidase activity 1 Q15040,O00303 413 5.09e-03 7 2 1 0.500 0.143 GO:0075522 BP 1 IRES-dependent viral translational initiation 1 O00303 413 7.26e-03 10 2 1 0.500 0.100 GO:0019081 BP 1 viral translation 1 O00303 413 7.99e-03 11 2 1 0.500 0.091 GO:0002192 BP 1 IRES-dependent translational initiation 1 O00303 413 1.02e-02 14 2 1 0.500 0.071 GO:0002190 BP 1 cap-independent translational initiation 1 O00303 413 1.16e-02 16 2 1 0.500 0.062 GO:0002183 BP 1 cytoplasmic translational initiation 1 O00303 413 1.23e-02 17 2 1 0.500 0.059 GO:0005852 CC 1 eukaryotic translation initiation factor 3 complex 1 O00303 413 1.38e-02 662 2 2 1.000 0.003 GO:0070647 BP 1 protein modification by small protein conjugation or removal 1 Q15040,O00303 413 1.52e-02 21 2 1 0.500 0.048 GO:0031369 MF 1 translation initiation factor binding 1 O00303 413 1.69e-02 52 2 1 0.500 0.019 REAC:72695 rea 1 Formation of the ternary complex, and subsequently, the 43S complex 1 O00303 413 1.92e-02 59 2 1 0.500 0.017 REAC:72649 rea 1 Translation initiation complex formation 1 O00303 413 1.92e-02 59 2 1 0.500 0.017 REAC:72702 rea 1 Ribosomal scanning and start codon recognition 1 O00303 413 1.95e-02 60 2 1 0.500 0.017 REAC:72662 rea 1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1 O00303 413 2.54e-02 35 2 1 0.500 0.029 GO:0003743 MF 1 translation initiation factor activity 1 O00303 413 2.76e-02 937 2 2 1.000 0.002 GO:0006508 BP 1 proteolysis 1 Q15040,O00303 413 3.08e-02 1169 2 2 1.000 0.002 REAC:392499 rea 1 Metabolism of proteins 1 Q15040,O00303 413 3.24e-02 100 2 1 0.500 0.010 REAC:72689 rea 1 Formation of a pool of free 40S subunits 1 O00303 413 3.55e-02 49 2 1 0.500 0.020 GO:0002181 BP 1 cytoplasmic translation 1 O00303 413 3.56e-02 110 2 1 0.500 0.009 REAC:156827 rea 1 L13a-mediated translational silencing of Ceruloplasmin expression 1 O00303 413 3.59e-02 111 2 1 0.500 0.009 REAC:72706 rea 1 GTP hydrolysis and joining of the 60S ribosomal subunit 1 O00303 413 3.82e-02 118 2 1 0.500 0.008 REAC:72613 rea 1 Eukaryotic Translation Initiation 1 O00303 413 3.82e-02 118 2 1 0.500 0.008 REAC:72737 rea 1 Cap-dependent Translation Initiation 1 O00303 413 4.07e-02 2177 2 2 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q15040,O00303 413 5.00e-02 478 2 2 1.000 0.004 TF:M00017_0 tf 1 Factor: ATF; motif: CNSTGACGTNNNYC; match class: 0 1 Q15040,O00303 413 5.00e-02 69 2 1 0.500 0.014 GO:0008135 MF 1 translation factor activity, RNA binding 1 O00303 413 5.00e-02 155 2 1 0.500 0.006 REAC:72766 rea 1 Translation 1 O00303 413 5.00e-02 12 2 1 0.500 0.083 CORUM:742 cor 1 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) 1 O00303 414 8.88e-12 12 6 5 0.833 0.417 CORUM:1194 cor 1 E2F-6 complex 1 Q969R5,Q9BYE7,O75461,Q8IWI9,Q14186 414 8.92e-04 2256 6 5 0.833 0.002 TF:M04287_1 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 1 Q969R5,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.41e-03 3 6 1 0.167 0.333 TF:M05905_0 tf 1 Factor: ZNF649; motif: NGNTAAAWCGGA; match class: 0 1 Q8IWI9 414 2.36e-03 5 6 1 0.167 0.200 TF:M06234_0 tf 1 Factor: ZNF91; motif: NGKGRATGCCGM; match class: 0 1 Q14186 414 4.41e-03 190 6 2 0.333 0.011 HPA:040020_03 hpa 1 soft tissue 2; chondrocytes[Uncertain,High] 1 Q8IWI9,Q14186 414 7.27e-03 5604 6 6 1.000 0.001 TF:M02011_0 tf 1 Factor: HES-1; motif: GSCACGMGMC; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 7.78e-03 27 6 2 0.333 0.074 GO:0044665 CC 1 MLL1/2 complex 1 O75461,Q8IWI9 414 7.78e-03 27 6 2 0.333 0.074 GO:0071339 CC 1 MLL1 complex 1 O75461,Q8IWI9 414 7.81e-03 3 6 1 0.167 0.333 CORUM:3900 cor 1 GABP(gamma)1-E2F1-DP1 complex 1 Q14186 414 7.81e-03 3 6 1 0.167 0.333 CORUM:1473 cor 1 E2F5-RB2-DP1 complex 1 Q14186 414 1.01e-02 342 6 2 0.333 0.006 TF:M04131_0 tf 1 Factor: TBX21; motif: AAGGTGTGAA; match class: 0 1 Q969R5,Q8IWI9 414 1.10e-02 6003 6 6 1.000 0.001 TF:M04433_0 tf 1 Factor: PRRX2; motif: NYAATTAN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.13e-02 24 6 1 0.167 0.042 TF:M05776_0 tf 1 Factor: ZNF394; motif: KGGTGAAGMAAM; match class: 0 1 Q8IWI9 414 1.19e-02 2310 6 4 0.667 0.002 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 Q6P1R3,O75461,Q8IWI9,Q14186 414 1.29e-02 1182 6 3 0.500 0.003 TF:M03924_1 tf 1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 1 Q969R5,O75461,Q8IWI9 414 1.30e-02 5 6 1 0.167 0.200 CORUM:2975 cor 1 SMAD3-E2F4/5-p107-DP1 complex 1 Q14186 414 1.37e-02 6224 6 6 1.000 0.001 TF:M01107_0 tf 1 Factor: RUSH-1alpha; motif: NNMCWTNKNN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.50e-02 32 6 1 0.167 0.031 TF:M06591_0 tf 1 Factor: ZNF681; motif: NGGGATAGAAGA; match class: 0 1 Q8IWI9 414 1.56e-02 6 6 1 0.167 0.167 CORUM:1474 cor 1 SMAD3/4-E2F4/5-p107-DP1 complex 1 Q14186 414 1.61e-02 6396 6 6 1.000 0.001 TF:M07387_0 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.64e-02 6420 6 6 1.000 0.001 TF:M04324_0 tf 1 Factor: GBX2; motif: NNYAATTANN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.79e-02 6510 6 6 1.000 0.001 TF:M07053_0 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 1.94e-02 6597 6 6 1.000 0.001 TF:M03891_0 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 2.04e-02 6657 6 6 1.000 0.001 TF:M04384_0 tf 1 Factor: LBX2; motif: NNYAATTANN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461,Q8IWI9,Q14186 414 2.10e-02 45 6 1 0.167 0.022 TF:M06639_0 tf 1 Factor: znf559; motif: NGKGCCGACCGC; match class: 0 1 Q8IWI9 414 2.29e-02 49 6 1 0.167 0.020 TF:M05632_0 tf 1 Factor: ZNF286B; motif: NGYTTWGAAARA; match class: 0 1 Q6P1R3 414 2.29e-02 49 6 1 0.167 0.020 TF:M03789_1 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 1 1 Q8IWI9 414 2.38e-02 51 6 1 0.167 0.020 TF:M00416_1 tf 1 Factor: Cart-1; motif: NNNTAATTNNCATTANCN; match class: 1 1 Q9BYE7 414 2.46e-02 547 6 2 0.333 0.004 TF:M01043_0 tf 1 Factor: Nkx2-5; motif: TSYCACTTSM; match class: 0 1 Q9BYE7,O75461 414 2.57e-02 559 6 2 0.333 0.004 TF:M05709_0 tf 1 Factor: znf136; motif: NGRWYGWAGAGA; match class: 0 1 Q9BYE7,O75461 414 2.61e-02 56 6 1 0.167 0.018 TF:M03951_0 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 0 1 Q969R5 414 2.75e-02 59 6 1 0.167 0.017 TF:M01657_1 tf 1 Factor: GLI3; motif: GTGGGTGGT; match class: 1 1 Q14186 414 2.89e-02 2954 6 4 0.667 0.001 TF:M01861_0 tf 1 Factor: ATF-1; motif: TNACGTCAN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,Q14186 414 2.91e-02 53 6 1 0.167 0.019 HPA:040020_13 hpa 1 soft tissue 2; chondrocytes[Supportive,High] 1 Q14186 414 2.96e-02 1601 6 3 0.500 0.002 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 Q6P1R3,Q8IWI9,Q14186 414 2.96e-02 1602 6 3 0.500 0.002 TF:M00938_0 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 0 1 Q9BYE7,O75461,Q14186 414 2.98e-02 64 6 1 0.167 0.016 TF:M05899_0 tf 1 Factor: ZNF454; motif: TTGAAAGCGTCTR; match class: 0 1 Q14186 414 3.09e-02 1380 6 3 0.500 0.002 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 Q6P1R3,Q8IWI9,Q14186 414 3.09e-02 3011 6 4 0.667 0.001 TF:M02102_0 tf 1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 0 1 Q9BYE7,O75461,Q8IWI9,Q14186 414 3.44e-02 3103 6 4 0.667 0.001 TF:M02075_0 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 0 1 Q6P1R3,O75461,Q8IWI9,Q14186 414 3.46e-02 4904 6 5 0.833 0.001 TF:M00272_1 tf 1 Factor: p53; motif: NGRCWTGYCY; match class: 1 1 Q969R5,Q6P1R3,O75461,Q8IWI9,Q14186 414 3.53e-02 76 6 1 0.167 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q9BYE7 414 3.58e-02 77 6 1 0.167 0.013 TF:M05715_0 tf 1 Factor: ZNF133; motif: KGGTAAAAAAAA; match class: 0 1 Q14186 414 3.67e-02 3160 6 4 0.667 0.001 TF:M00130_1 tf 1 Factor: FOXD3; motif: NAWTGTTTRTTT; match class: 1 1 Q969R5,Q6P1R3,Q9BYE7,Q8IWI9 414 3.70e-02 1740 6 3 0.500 0.002 TF:M04412_1 tf 1 Factor: NKX2-8; motif: NCACTTSAN; match class: 1 1 Q9BYE7,O75461,Q8IWI9 414 3.71e-02 3170 6 4 0.667 0.001 TF:M00293_1 tf 1 Factor: Freac-7; motif: WNNANATAAAYANNNN; match class: 1 1 Q6P1R3,Q9BYE7,O75461,Q14186 414 3.80e-02 3193 6 4 0.667 0.001 TF:M00795_0 tf 1 Factor: Octamer; motif: TNATTTGCATN; match class: 0 1 Q969R5,Q6P1R3,Q9BYE7,O75461 414 3.83e-02 692 6 2 0.333 0.003 TF:M01652_1 tf 1 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY; match class: 1 1 Q969R5,Q6P1R3 414 3.91e-02 1776 6 3 0.500 0.002 TF:M01843_1 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 1 1 O75461,Q8IWI9,Q14186 414 3.94e-02 703 6 2 0.333 0.003 TF:M04048_0 tf 1 Factor: MYBL2; motif: NNAACCGTTAN; match class: 0 1 Q969R5,Q8IWI9 414 3.94e-02 703 6 2 0.333 0.003 TF:M03872_1 tf 1 Factor: HNF-1beta; motif: GTTAATYATTAACY; match class: 1 1 Q6P1R3,Q9BYE7 414 4.03e-02 87 6 1 0.167 0.011 TF:M01045_1 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 1 1 Q9BYE7 414 4.16e-02 1818 6 3 0.500 0.002 TF:M07062_0 tf 1 Factor: RREB1; motif: GRSDSGGGKTGGGKGG; match class: 0 1 Q6P1R3,Q8IWI9,Q14186 414 4.21e-02 91 6 1 0.167 0.011 TF:M01716_1 tf 1 Factor: MATH1; motif: NCASCTGGYN; match class: 1 1 Q14186 414 4.36e-02 5164 6 5 0.833 0.001 TF:M01843_0 tf 1 Factor: DEC2; motif: SNTCACGTGS; match class: 0 1 Q969R5,Q9BYE7,O75461,Q8IWI9,Q14186 414 4.36e-02 5164 6 5 0.833 0.001 TF:M04191_1 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 1 1 Q969R5,Q6P1R3,Q9BYE7,Q8IWI9,Q14186 414 4.47e-02 753 6 2 0.333 0.003 TF:M00796_1 tf 1 Factor: USF; motif: NRCCACGTGASN; match class: 1 1 O75461,Q8IWI9 414 4.53e-02 98 6 1 0.167 0.010 TF:M07233_1 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 1 1 Q8IWI9 414 4.58e-02 1886 6 3 0.500 0.002 TF:M00217_1 tf 1 Factor: USF; motif: NCACGTGN; match class: 1 1 O75461,Q8IWI9,Q14186 414 4.65e-02 769 6 2 0.333 0.003 TF:M04571_1 tf 1 Factor: TFEC; motif: RNCACRTGAY; match class: 1 1 O75461,Q8IWI9 414 4.94e-02 107 6 1 0.167 0.009 TF:M04163_0 tf 1 Factor: BHLHE41; motif: NKCACGTGMC; match class: 0 1 Q8IWI9 414 5.00e-02 4 6 1 0.167 0.250 REAC:111448 rea 1 Activation of NOXA and translocation to mitochondria 1 Q14186 414 5.00e-02 68 6 2 0.333 0.029 GO:0035097 CC 1 histone methyltransferase complex 1 O75461,Q8IWI9 414 5.00e-02 4 6 1 0.167 0.250 REAC:4551638 rea 1 SUMOylation of chromatin organization proteins 1 Q969R5 415 3.13e-02 5 2 1 0.500 0.200 GO:0046602 BP 1 regulation of mitotic centrosome separation 1 Q6P2H3 415 5.00e-02 8 2 1 0.500 0.125 GO:0007100 BP 1 mitotic centrosome separation 1 Q6P2H3 415 5.00e-02 35 2 1 0.500 0.029 REAC:3769402 rea 1 Deactivation of the beta-catenin transactivating complex 1 Q9UN79 416 2.05e-03 239 4 2 0.500 0.008 TF:M06564_0 tf 1 Factor: ZNF578; motif: KGGACGKGAAAA; match class: 0 1 Q9GZT3,P42704 416 2.41e-03 1 4 1 0.250 1.000 OMIM:220111 omi 1 LEIGH SYNDROME, FRENCH CANADIAN TYPE; LSFC;;CYTOCHROME c OXIDASE DEFICIENCY, FRENCH CANADIAN TYPE;;COX DEFICIENCY, FRENCH CANADIAN TYPE;;COX DEFICIENCY, SAGUENAY-LAC-SAINT-JEAN TYPE;;LEIGH SYNDROME, SAGUENAY-LAC-SAINT-JEAN TYPE 1 P42704 416 3.45e-03 11 4 1 0.250 0.091 TF:M06519_0 tf 1 Factor: ZNF397; motif: NCGKGGATMAGA; match class: 0 1 P12830 416 3.77e-03 12 4 1 0.250 0.083 TF:M04353_1 tf 1 Factor: HOXC11; motif: NGTCGTAAAAN; match class: 1 1 P12830 416 4.06e-03 2 4 1 0.250 0.500 CORUM:5281 cor 1 Cell-cell junction complex (CDH1-CTNNB1) 1 P12830 416 4.06e-03 2 4 1 0.250 0.500 CORUM:5319 cor 1 CDH1-CKS1B complex 1 P12830 416 4.06e-03 2 4 1 0.250 0.500 CORUM:5320 cor 1 CDH1-SKP2 complex 1 P12830 416 5.65e-03 18 4 1 0.250 0.056 TF:M04164_1 tf 1 Factor: BHLHE22; motif: AAACATATGKTN; match class: 1 1 Q9GZT3 416 5.65e-03 18 4 1 0.250 0.056 TF:M04164_0 tf 1 Factor: BHLHE22; motif: AAACATATGKTN; match class: 0 1 Q9GZT3 416 6.09e-03 3 4 1 0.250 0.333 CORUM:1834 cor 1 ITGAE-ITGB7-CDH1 complex 1 P12830 416 6.09e-03 3 4 1 0.250 0.333 CORUM:521 cor 1 Polycystin-1-E-cadherin-beta-catenin complex 1 P12830 416 7.11e-03 449 4 2 0.500 0.004 TF:M01747_0 tf 1 Factor: BRF-1; motif: GGGTTCGANTCCC; match class: 0 1 P12830,Q9GZT3 416 7.22e-03 3 4 1 0.250 0.333 OMIM:137215 omi 1 GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC;;GASTRIC CANCER, HEREDITARY DIFFUSE; HDGC;;GASTRIC CANCER, FAMILIAL DIFFUSEBREAST CANCER, LOBULAR, INCLUDED; LBC, INCLUDED;;GASTRIC CANCER, FAMILIAL DIFFUSE, AND CLEFT LIP WITH OR WITHOUT CLEFTPALATE, INCLUDED 1 P12830 416 7.22e-03 3 4 1 0.250 0.333 OMIM:119530 omi 1 Orofacial Cleft 1 P12830 416 7.83e-03 25 4 1 0.250 0.040 TF:M04359_1 tf 1 Factor: HOXD11; motif: RTCGTAAAAN; match class: 1 1 P12830 416 8.11e-03 4 4 1 0.250 0.250 CORUM:1826 cor 1 SMAD3-HEF1-APC10-CDH1 complex 1 P12830 416 8.11e-03 4 4 1 0.250 0.250 CORUM:522 cor 1 Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex 1 P12830 416 9.93e-03 469 4 2 0.500 0.004 MI:hsa-miR-377 mi 1 MI:hsa-miR-377 1 O00192,P42704 416 1.03e-02 33 4 1 0.250 0.030 TF:M06429_0 tf 1 Factor: ZSCAN2; motif: NAGGAAARCCKC; match class: 0 1 P12830 416 1.06e-02 2 4 1 0.250 0.500 GO:0010226 BP 1 response to lithium ion 1 P12830 416 1.06e-02 2 4 1 0.250 0.500 GO:0071285 BP 1 cellular response to lithium ion 1 P12830 416 1.14e-02 4156 4 4 1.000 0.001 TF:M02096_0 tf 1 Factor: ipf1; motif: YTAATGN; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 1.20e-02 5 4 1 0.250 0.200 OMIM:608089 omi 1 ENDOMETRIAL CANCER 1 P12830 416 1.22e-02 4233 4 4 1.000 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 P12830,O00192,Q9GZT3,P42704 416 1.23e-02 505 4 2 0.500 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 P12830,P42704 416 1.25e-02 40 4 1 0.250 0.025 TF:M03957_0 tf 1 Factor: ONECUT3; motif: NAAAAATCRATAAN; match class: 0 1 P42704 416 1.43e-02 1722 4 3 0.750 0.002 HPA:028010_03 hpa 1 parathyroid gland; glandular cells[Uncertain,High] 1 P12830,Q9GZT3,P42704 416 1.44e-02 6 4 1 0.250 0.167 OMIM:167000 omi 1 OVARIAN CANCEROVARIAN CANCER, EPITHELIAL, INCLUDED 1 P12830 416 1.49e-02 657 4 2 0.500 0.003 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 P12830,O00192 416 1.50e-02 48 4 1 0.250 0.021 TF:M05920_0 tf 1 Factor: ZNF556; motif: NGATCCGGTMGA; match class: 0 1 O00192 416 1.52e-02 564 4 2 0.500 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 P12830,P42704 416 1.54e-02 567 4 2 0.500 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P12830,P42704 416 1.56e-02 50 4 1 0.250 0.020 TF:M06161_0 tf 1 Factor: ZNF117; motif: NGGGGAGGACGM; match class: 0 1 Q9GZT3 416 1.59e-02 51 4 1 0.250 0.020 TF:M06391_0 tf 1 Factor: ZNF836; motif: NGGGGYTCCAGM; match class: 0 1 O00192 416 1.67e-02 4 4 1 0.250 0.250 HP:0005231 hp 1 Chronic gastritis 1 P12830 416 1.67e-02 4 4 1 0.250 0.250 HP:0002582 hp 1 Chronic atrophic gastritis 1 P12830 416 1.69e-02 596 4 2 0.500 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 P12830,P42704 416 1.70e-02 4594 4 4 1.000 0.001 TF:M02014_1 tf 1 Factor: HNF-3beta; motif: NTRTTTRYT; match class: 1 1 P12830,O00192,Q9GZT3,P42704 416 1.77e-02 2188 4 3 0.750 0.001 TF:M00622_0 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 0 1 P12830,Q9GZT3,P42704 416 1.81e-02 616 4 2 0.500 0.003 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 P12830,P42704 416 1.84e-02 59 4 1 0.250 0.017 TF:M04046_0 tf 1 Factor: MYBL2; motif: AACSGTTAACSGNY; match class: 0 1 Q9GZT3 416 1.85e-02 624 4 2 0.500 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P12830,P42704 416 1.86e-02 625 4 2 0.500 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 P12830,P42704 416 1.91e-02 634 4 2 0.500 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P12830,P42704 416 1.92e-02 8 4 1 0.250 0.125 OMIM:176807 omi 1 PROSTATE CANCER 1 P12830 416 2.00e-02 650 4 2 0.500 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 P12830,P42704 416 2.01e-02 1941 4 3 0.750 0.002 HPA:013010_03 hpa 1 epididymis; glandular cells[Uncertain,High] 1 P12830,O00192,P42704 416 2.02e-02 653 4 2 0.500 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 P12830,P42704 416 2.09e-02 67 4 1 0.250 0.015 TF:M00287_1 tf 1 Factor: NF-Y; motif: NNNRRCCAATSRGNNN; match class: 1 1 P12830 416 2.09e-02 5 4 1 0.250 0.200 HP:0006774 hp 1 Ovarian papillary adenocarcinoma 1 P12830 416 2.10e-02 786 4 2 0.500 0.003 TF:M00773_1 tf 1 Factor: c-MYB; motif: NNNGNCAGTTN; match class: 1 1 Q9GZT3,P42704 416 2.12e-02 27 4 1 0.250 0.037 KEGG:05216 keg 1 Thyroid cancer 1 P12830 416 2.22e-02 808 4 2 0.500 0.002 TF:M01796_0 tf 1 Factor: BDP1; motif: GGWNTYGAACYC; match class: 0 1 P12830,Q9GZT3 416 2.22e-02 11 4 1 0.250 0.091 CORUM:5177 cor 1 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 1 P12830 416 2.28e-02 4949 4 4 1.000 0.001 TF:M00289_0 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 2.37e-02 76 4 1 0.250 0.013 TF:M00639_0 tf 1 Factor: HNF-6; motif: HWAAATCAATAW; match class: 0 1 P42704 416 2.43e-02 78 4 1 0.250 0.013 TF:M03956_0 tf 1 Factor: ONECUT2; motif: NAAAAATCRATANN; match class: 0 1 P42704 416 2.46e-02 79 4 1 0.250 0.013 TF:M01111_1 tf 1 Factor: RBP-Jkappa; motif: TTCCCACK; match class: 1 1 P42704 416 2.47e-02 5047 4 4 1.000 0.001 TF:M05467_0 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 2.51e-02 6 4 1 0.250 0.167 HP:0100541 hp 1 Femoral hernia 1 O00192 416 2.51e-02 6 4 1 0.250 0.167 HP:0008211 hp 1 Parathyroid agenesis 1 O00192 416 2.51e-02 6 4 1 0.250 0.167 HP:0006549 hp 1 Unilateral primary pulmonary dysgenesis 1 O00192 416 2.52e-02 733 4 2 0.500 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 P12830,P42704 416 2.64e-02 85 4 1 0.250 0.012 TF:M05660_0 tf 1 Factor: ZNF286B; motif: NTTGGCGGATGM; match class: 0 1 O00192 416 2.65e-02 5 4 1 0.250 0.200 GO:0071680 BP 1 response to indole-3-methanol 1 P12830 416 2.65e-02 5 4 1 0.250 0.200 GO:0071681 BP 1 cellular response to indole-3-methanol 1 P12830 416 2.65e-02 753 4 2 0.500 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P12830,P42704 416 2.71e-02 761 4 2 0.500 0.003 HPA:045010_13 hpa 1 thyroid gland; glandular cells[Supportive,High] 1 P12830,P42704 416 2.71e-02 87 4 1 0.250 0.011 TF:M02106_1 tf 1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 1 P12830 416 2.74e-02 88 4 1 0.250 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 Q9GZT3 416 2.74e-02 903 4 2 0.500 0.002 TF:M04415_1 tf 1 Factor: NKX6-1; motif: NTMATTAA; match class: 1 1 Q9GZT3,P42704 416 2.77e-02 89 4 1 0.250 0.011 TF:M04229_0 tf 1 Factor: FOXB1; motif: GAATGACACRGCGA; match class: 0 1 P12830 416 2.78e-02 2177 4 3 0.750 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P12830,Q9GZT3,P42704 416 2.82e-02 36 4 1 0.250 0.028 KEGG:05219 keg 1 Bladder cancer 1 P12830 416 2.83e-02 5220 4 4 1.000 0.001 TF:M00422_0 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 2.92e-02 7 4 1 0.250 0.143 HP:0100754 hp 1 Mania 1 O00192 416 2.92e-02 7 4 1 0.250 0.143 HP:0007302 hp 1 Bipolar affective disorder 1 O00192 416 2.93e-02 794 4 2 0.500 0.003 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 Q9GZT3,P42704 416 3.04e-02 98 4 1 0.250 0.010 TF:M04185_1 tf 1 Factor: OLIG1; motif: AMCATATGKT; match class: 1 1 Q9GZT3 416 3.04e-02 98 4 1 0.250 0.010 TF:M04185_0 tf 1 Factor: OLIG1; motif: AMCATATGKT; match class: 0 1 Q9GZT3 416 3.15e-02 2274 4 3 0.750 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 P12830,Q9GZT3,P42704 416 3.23e-02 836 4 2 0.500 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P12830,P42704 416 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P12830,P42704 416 3.26e-02 2714 4 3 0.750 0.001 TF:M04413_0 tf 1 Factor: NKX3-1; motif: NCCACTTAA; match class: 0 1 P12830,Q9GZT3,P42704 416 3.30e-02 2727 4 3 0.750 0.001 TF:M04217_0 tf 1 Factor: MAFK; motif: NAWWNTGCTGAS; match class: 0 1 P12830,Q9GZT3,P42704 416 3.34e-02 8 4 1 0.250 0.125 HP:0011611 hp 1 Interrupted aortic arch 1 O00192 416 3.34e-02 8 4 1 0.250 0.125 HP:0011768 hp 1 Parathyroid dysgenesis 1 O00192 416 3.34e-02 8 4 1 0.250 0.125 HP:0000860 hp 1 Parathyroid hypoplasia 1 O00192 416 3.51e-02 2787 4 3 0.750 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 P12830,O00192,Q9GZT3 416 3.52e-02 874 4 2 0.500 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 P12830,P42704 416 3.69e-02 119 4 1 0.250 0.008 TF:M00693_1 tf 1 Factor: E12; motif: RRCAGGTGNCV; match class: 1 1 O00192 416 3.71e-02 7 4 1 0.250 0.143 GO:0016600 CC 1 flotillin complex 1 P12830 416 3.71e-02 7 4 1 0.250 0.143 GO:0032794 MF 1 GTPase activating protein binding 1 P12830 416 3.71e-02 7 4 1 0.250 0.143 GO:0016342 CC 1 catenin complex 1 P12830 416 3.73e-02 902 4 2 0.500 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P12830,P42704 416 3.76e-02 9 4 1 0.250 0.111 HP:0100753 hp 1 Schizophrenia 1 O00192 416 3.82e-02 49 4 1 0.250 0.020 KEGG:05213 keg 1 Endometrial cancer 1 P12830 416 3.85e-02 2880 4 3 0.750 0.001 TF:M00088_1 tf 1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 1 P12830,Q9GZT3,P42704 416 3.89e-02 50 4 1 0.250 0.020 KEGG:05130 keg 1 Pathogenic Escherichia coli infection 1 P12830 416 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P12830,P42704 416 4.09e-02 5725 4 4 1.000 0.001 TF:M00280_0 tf 1 Factor: RFX1; motif: NNGTNRCNWRGYAACNN; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 4.11e-02 5730 4 4 1.000 0.001 TF:M00086_0 tf 1 Factor: Ik-1; motif: NHNTGGGAATRCC; match class: 0 1 P12830,O00192,Q9GZT3,P42704 416 4.17e-02 10 4 1 0.250 0.100 HP:0100621 hp 1 Dysgerminoma 1 P12830 416 4.17e-02 10 4 1 0.250 0.100 HP:0100620 hp 1 Germinoma 1 P12830 416 4.20e-02 54 4 1 0.250 0.019 KEGG:05218 keg 1 Melanoma 1 P12830 416 4.24e-02 137 4 1 0.250 0.007 TF:M04339_1 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 1 1 P12830 416 4.24e-02 137 4 1 0.250 0.007 TF:M04352_1 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 1 1 P12830 416 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P12830,P42704 416 4.31e-02 973 4 2 0.500 0.002 HPA:023010_03 hpa 1 lymph node; germinal center cells[Uncertain,High] 1 Q9GZT3,P42704 416 4.34e-02 977 4 2 0.500 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P12830,P42704 416 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P12830,P42704 416 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P12830,P42704 416 4.59e-02 11 4 1 0.250 0.091 HP:0005263 hp 1 Gastritis 1 P12830 416 4.59e-02 11 4 1 0.250 0.091 HP:0000220 hp 1 Velopharyngeal insufficiency 1 O00192 416 4.63e-02 150 4 1 0.250 0.007 TF:M00292_1 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 1 1 P42704 416 4.66e-02 3086 4 3 0.750 0.001 TF:M07265_0 tf 1 Factor: Nrf2; motif: NNTGACTCAGCAN; match class: 0 1 P12830,O00192,Q9GZT3 416 4.67e-02 5019 4 4 1.000 0.001 HPA:028010_02 hpa 1 parathyroid gland; glandular cells[Uncertain,Medium] 1 P12830,O00192,Q9GZT3,P42704 416 4.72e-02 153 4 1 0.250 0.007 TF:M05731_0 tf 1 Factor: ZNF660; motif: NGGGGGGAACSM; match class: 0 1 O00192 416 4.73e-02 3101 4 3 0.750 0.001 TF:M03810_0 tf 1 Factor: RXR:PXR; motif: NNNTGAMCTYNNNTGAMCYN; match class: 0 1 P12830,O00192,Q9GZT3 416 4.94e-02 3152 4 3 0.750 0.001 TF:M04379_1 tf 1 Factor: ISL2; motif: GCAMTTAR; match class: 1 1 P12830,Q9GZT3,P42704 416 4.97e-02 161 4 1 0.250 0.006 TF:M07361_1 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 1 1 O00192 416 4.98e-02 3160 4 3 0.750 0.001 TF:M00130_1 tf 1 Factor: FOXD3; motif: NAWTGTTTRTTT; match class: 1 1 P12830,O00192,Q9GZT3 416 5.00e-02 274 4 2 0.500 0.007 GO:0048471 CC 1 perinuclear region of cytoplasm 1 P12830,P42704 416 5.00e-02 12 4 1 0.250 0.083 HP:0000201 hp 1 Pierre-Robin sequence 1 O00192 416 5.00e-02 21 4 1 0.250 0.048 OMIM:114480 omi 1 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED 1 P12830 416 5.00e-02 10 4 1 0.250 0.100 REAC:351906 rea 1 Apoptotic cleavage of cell adhesion proteins 1 P12830 416 5.00e-02 10 4 1 0.250 0.100 REAC:5626467 rea 1 RHO GTPases activate IQGAPs 1 P12830 416 5.00e-02 12 4 1 0.250 0.083 HP:0006565 hp 1 Increased hepatocellular lipid droplets 1 P42704 416 5.00e-02 25 4 1 0.250 0.040 CORUM:5233 cor 1 TNF-alpha/NF-kappa B signaling complex 5 1 P42704 416 5.00e-02 12 4 1 0.250 0.083 HP:0100735 hp 1 Hypertensive crisis 1 O00192 416 5.00e-02 12 4 1 0.250 0.083 HP:0012126 hp 1 Stomach cancer 1 P12830 417 2.36e-08 19 3 3 1.000 0.158 GO:0005686 CC 1 U2 snRNP 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 4.92e-08 24 3 3 1.000 0.125 GO:0005689 CC 1 U12-type spliceosomal complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 5.59e-08 25 3 3 1.000 0.120 GO:0071011 CC 1 precatalytic spliceosome 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 6.03e-07 54 3 3 1.000 0.056 GO:0097525 CC 1 spliceosomal snRNP complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 8.75e-07 61 3 3 1.000 0.049 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 4.85e-06 8 3 3 1.000 0.375 CORUM:1737 cor 1 SF3b complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 1.26e-05 147 3 3 1.000 0.020 GO:0005681 CC 1 spliceosomal complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 7.46e-05 265 3 3 1.000 0.011 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 7.46e-05 265 3 3 1.000 0.011 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 7.78e-05 173 3 3 1.000 0.017 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 7.80e-05 269 3 3 1.000 0.011 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 8.77e-05 180 3 3 1.000 0.017 REAC:72172 rea 1 mRNA Splicing 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 1.39e-04 326 3 3 1.000 0.009 GO:0008380 BP 1 RNA splicing 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 1.61e-04 342 3 3 1.000 0.009 GO:0006397 BP 1 mRNA processing 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 1.79e-04 228 3 3 1.000 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 4.72e-04 33 3 3 1.000 0.091 CORUM:2755 cor 1 17S U2 snRNP 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 5.73e-04 522 3 3 1.000 0.006 GO:0016071 BP 1 mRNA metabolic process 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 8.42e-04 51 3 2 0.667 0.039 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q9Y3B4,Q9BWJ5 417 8.67e-04 599 3 3 1.000 0.005 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 8.71e-04 600 3 3 1.000 0.005 GO:1990904 CC 1 ribonucleoprotein complex 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 1.07e-03 88 3 2 0.667 0.023 GO:0071013 CC 1 catalytic step 2 spliceosome 1 Q7RTV0,Q9Y3B4 417 1.72e-03 752 3 3 1.000 0.004 GO:0006396 BP 1 RNA processing 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 7.01e-03 531 3 2 0.667 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 7.24e-03 540 3 2 0.667 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 8.19e-03 2177 3 3 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 9.15e-03 608 3 2 0.667 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 9.93e-03 634 3 2 0.667 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 1.32e-02 733 3 2 0.667 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 1.39e-02 753 3 2 0.667 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 1.47e-02 775 3 2 0.667 0.003 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 1.98e-02 902 3 2 0.667 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 2.10e-02 930 3 2 0.667 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 2.12e-02 2988 3 3 1.000 0.001 HPA:009020_03 hpa 1 colon; glandular cells[Uncertain,High] 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 2.15e-02 943 3 2 0.667 0.002 HPA:035040_03 hpa 1 skin 1; melanocytes[Uncertain,High] 1 Q7RTV0,Q9BWJ5 417 2.27e-02 969 3 2 0.667 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 2.28e-02 3061 3 3 1.000 0.001 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 2.62e-02 3206 3 3 1.000 0.001 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 2.79e-02 1078 3 2 0.667 0.002 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 3.05e-02 1129 3 2 0.667 0.002 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 3.07e-02 1133 3 2 0.667 0.002 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q7RTV0,Q9Y3B4 417 3.08e-02 1135 3 2 0.667 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 3.55e-02 1221 3 2 0.667 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 Q7RTV0,Q9Y3B4 417 3.78e-02 1263 3 2 0.667 0.002 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 Q7RTV0,Q9Y3B4 417 4.04e-02 1307 3 2 0.667 0.002 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.06e-02 1310 3 2 0.667 0.002 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 Q7RTV0,Q9Y3B4 417 4.17e-02 1329 3 2 0.667 0.002 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.36e-02 1360 3 2 0.667 0.001 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.43e-02 1372 3 2 0.667 0.001 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.58e-02 1396 3 2 0.667 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.63e-02 1403 3 2 0.667 0.001 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q7RTV0,Q9Y3B4 417 4.86e-02 3939 3 3 1.000 0.001 HPA:009030_02 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Medium] 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 5.00e-02 377 3 2 0.667 0.005 MI:hsa-miR-326 mi 1 MI:hsa-miR-326 1 Q7RTV0,Q9BWJ5 417 5.00e-02 1 3 1 0.333 1.000 TF:M06549_1 tf 1 Factor: ZNF721; motif: NGARGTGGGGTG; match class: 1 1 Q9Y3B4 417 5.00e-02 128 3 3 1.000 0.023 KEGG:03040 keg 1 Spliceosome 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 5.00e-02 1485 3 3 1.000 0.002 REAC:74160 rea 1 Gene Expression 1 Q7RTV0,Q9Y3B4,Q9BWJ5 417 5.00e-02 31 3 1 0.333 0.032 GO:0005684 CC 1 U2-type spliceosomal complex 1 Q9Y3B4 417 5.00e-02 1 3 1 0.333 1.000 TF:M05681_0 tf 1 Factor: ZNF200; motif: KGGTAAAACCGA; match class: 0 1 Q9Y3B4 417 5.00e-02 23 3 2 0.667 0.087 CORUM:430 cor 1 18S U11/U12 snRNP 1 Q9Y3B4,Q9BWJ5 418 1.57e-11 20 4 4 1.000 0.200 GO:1901687 BP 1 glutathione derivative biosynthetic process 1 P46439,P21266,Q03013,P28161 418 1.57e-11 20 4 4 1.000 0.200 GO:1901685 BP 1 glutathione derivative metabolic process 1 P46439,P21266,Q03013,P28161 418 7.67e-11 29 4 4 1.000 0.138 GO:0004364 MF 1 glutathione transferase activity 1 P46439,P21266,Q03013,P28161 418 5.27e-10 46 4 4 1.000 0.087 GO:0006749 BP 1 glutathione metabolic process 1 P46439,P21266,Q03013,P28161 418 7.45e-10 6 4 3 0.750 0.500 GO:0042178 BP 1 xenobiotic catabolic process 1 P21266,Q03013,P28161 418 1.19e-09 56 4 4 1.000 0.071 GO:0016765 MF 1 transferase activity, transferring alkyl or aryl (other than methyl) groups 1 P46439,P21266,Q03013,P28161 418 3.13e-09 9 4 3 0.750 0.333 GO:0043295 MF 1 glutathione binding 1 P21266,Q03013,P28161 418 4.35e-09 31 4 4 1.000 0.129 REAC:156590 rea 1 Glutathione conjugation 1 P46439,P21266,Q03013,P28161 418 4.47e-09 10 4 3 0.750 0.300 GO:1900750 MF 1 oligopeptide binding 1 P21266,Q03013,P28161 418 2.31e-08 116 4 4 1.000 0.034 GO:0006575 BP 1 cellular modified amino acid metabolic process 1 P46439,P21266,Q03013,P28161 418 9.16e-08 163 4 4 1.000 0.025 GO:0044272 BP 1 sulfur compound biosynthetic process 1 P46439,P21266,Q03013,P28161 418 1.87e-07 77 4 4 1.000 0.052 REAC:156580 rea 1 Phase II conjugation 1 P46439,P21266,Q03013,P28161 418 2.43e-07 35 4 3 0.750 0.086 GO:0072341 MF 1 modified amino acid binding 1 P21266,Q03013,P28161 418 6.45e-07 3 4 2 0.500 0.667 GO:0070458 BP 1 cellular detoxification of nitrogen compound 1 P21266,P28161 418 6.45e-07 3 4 2 0.500 0.667 GO:0018916 BP 1 nitrobenzene metabolic process 1 P21266,P28161 418 8.94e-07 287 4 4 1.000 0.014 GO:0006790 BP 1 sulfur compound metabolic process 1 P46439,P21266,Q03013,P28161 418 1.34e-06 61 4 3 0.750 0.049 GO:0006805 BP 1 xenobiotic metabolic process 1 P21266,Q03013,P28161 418 1.40e-06 62 4 3 0.750 0.048 GO:0071466 BP 1 cellular response to xenobiotic stimulus 1 P21266,Q03013,P28161 418 1.40e-06 62 4 3 0.750 0.048 GO:0009410 BP 1 response to xenobiotic stimulus 1 P21266,Q03013,P28161 418 1.43e-06 127 4 4 1.000 0.031 REAC:211859 rea 1 Biological oxidations 1 P46439,P21266,Q03013,P28161 418 2.15e-06 5 4 2 0.500 0.400 GO:0051410 BP 1 detoxification of nitrogen compound 1 P21266,P28161 418 7.77e-06 109 4 3 0.750 0.028 GO:1901681 MF 1 sulfur compound binding 1 P21266,Q03013,P28161 418 9.62e-06 117 4 3 0.750 0.026 GO:0042277 MF 1 peptide binding 1 P21266,Q03013,P28161 418 9.66e-06 10 4 2 0.500 0.200 GO:0042537 BP 1 benzene-containing compound metabolic process 1 P21266,P28161 418 1.29e-05 129 4 3 0.750 0.023 GO:0033218 MF 1 amide binding 1 P21266,Q03013,P28161 418 1.64e-05 592 4 4 1.000 0.007 GO:0006518 BP 1 peptide metabolic process 1 P46439,P21266,Q03013,P28161 418 3.28e-05 18 4 2 0.500 0.111 GO:1990748 BP 1 cellular detoxification 1 P21266,P28161 418 3.32e-05 706 4 4 1.000 0.006 GO:0043603 BP 1 cellular amide metabolic process 1 P46439,P21266,Q03013,P28161 418 4.07e-05 20 4 2 0.500 0.100 GO:0098754 BP 1 detoxification 1 P21266,P28161 418 7.01e-05 851 4 4 1.000 0.005 GO:0044711 BP 1 single-organism biosynthetic process 1 P46439,P21266,Q03013,P28161 418 1.16e-04 965 4 4 1.000 0.004 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 P46439,P21266,Q03013,P28161 418 1.50e-04 38 4 2 0.500 0.053 GO:0009636 BP 1 response to toxic substance 1 P21266,P28161 418 5.28e-04 445 4 3 0.750 0.007 GO:0042803 MF 1 protein homodimerization activity 1 P21266,Q03013,P28161 418 7.97e-04 397 4 3 0.750 0.008 MI:hsa-miR-939 mi 1 MI:hsa-miR-939 1 P46439,Q03013,P28161 418 8.05e-04 1565 4 4 1.000 0.003 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P46439,P21266,Q03013,P28161 418 8.26e-04 1 4 1 0.250 1.000 GO:0008065 BP 1 establishment of blood-nerve barrier 1 P21266 418 9.42e-04 420 4 3 0.750 0.007 MI:hsa-miR-483-3p mi 1 MI:hsa-miR-483-3p 1 P46439,Q03013,P28161 418 1.05e-03 560 4 3 0.750 0.005 GO:0046983 MF 1 protein dimerization activity 1 P21266,Q03013,P28161 418 1.16e-03 1715 4 4 1.000 0.002 GO:0016740 MF 1 transferase activity 1 P46439,P21266,Q03013,P28161 418 1.43e-03 483 4 3 0.750 0.006 MI:hsa-miR-95 mi 1 MI:hsa-miR-95 1 P21266,Q03013,P28161 418 1.49e-03 490 4 3 0.750 0.006 MI:hsa-miR-513-5p mi 1 MI:hsa-miR-513-5p 1 P21266,Q03013,P28161 418 1.60e-03 647 4 3 0.750 0.005 GO:0042802 MF 1 identical protein binding 1 P21266,Q03013,P28161 418 2.48e-03 3 4 1 0.250 0.333 GO:0060316 BP 1 positive regulation of ryanodine-sensitive calcium-release channel activity 1 P28161 418 3.30e-03 826 4 3 0.750 0.004 GO:0043168 MF 1 anion binding 1 P21266,Q03013,P28161 418 3.30e-03 4 4 1 0.250 0.250 GO:0014722 BP 1 regulation of skeletal muscle contraction by calcium ion signaling 1 P28161 418 3.30e-03 4 4 1 0.250 0.250 GO:0014809 BP 1 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 1 P28161 418 4.95e-03 6 4 1 0.250 0.167 GO:0031000 BP 1 response to caffeine 1 P28161 418 4.95e-03 6 4 1 0.250 0.167 GO:0071313 BP 1 cellular response to caffeine 1 P28161 418 5.77e-03 2560 4 4 1.000 0.002 GO:0044710 BP 1 single-organism metabolic process 1 P46439,P21266,Q03013,P28161 418 5.78e-03 7 4 1 0.250 0.143 GO:0071415 BP 1 cellular response to purine-containing compound 1 P28161 418 6.60e-03 8 4 1 0.250 0.125 GO:0051280 BP 1 negative regulation of release of sequestered calcium ion into cytosol 1 P28161 418 6.60e-03 8 4 1 0.250 0.125 GO:0060315 BP 1 negative regulation of ryanodine-sensitive calcium-release channel activity 1 P28161 418 6.60e-03 8 4 1 0.250 0.125 GO:0014819 BP 1 regulation of skeletal muscle contraction 1 P28161 418 7.21e-03 2707 4 4 1.000 0.001 GO:0005829 CC 1 cytosol 1 P46439,P21266,Q03013,P28161 418 7.43e-03 9 4 1 0.250 0.111 GO:0010523 BP 1 negative regulation of calcium ion transport into cytosol 1 P28161 418 7.43e-03 9 4 1 0.250 0.111 GO:0051284 BP 1 positive regulation of sequestering of calcium ion 1 P28161 418 7.43e-03 9 4 1 0.250 0.111 GO:0055119 BP 1 relaxation of cardiac muscle 1 P28161 418 7.67e-03 45 4 4 1.000 0.089 KEGG:00480 keg 1 Glutathione metabolism 1 P46439,P21266,Q03013,P28161 418 8.52e-03 1141 4 3 0.750 0.003 GO:0044248 BP 1 cellular catabolic process 1 P21266,Q03013,P28161 418 9.08e-03 11 4 1 0.250 0.091 GO:0090281 BP 1 negative regulation of calcium ion import 1 P28161 418 9.90e-03 12 4 1 0.250 0.083 GO:0050849 BP 1 negative regulation of calcium-mediated signaling 1 P28161 418 9.90e-03 12 4 1 0.250 0.083 GO:0050850 BP 1 positive regulation of calcium-mediated signaling 1 P28161 418 9.90e-03 12 4 1 0.250 0.083 GO:0004602 MF 1 glutathione peroxidase activity 1 P28161 418 9.90e-03 12 4 1 0.250 0.083 GO:0090075 BP 1 relaxation of muscle 1 P28161 418 1.06e-02 1230 4 3 0.750 0.002 GO:0019899 MF 1 enzyme binding 1 P21266,Q03013,P28161 418 1.07e-02 13 4 1 0.250 0.077 GO:0010881 BP 1 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 1 P28161 418 1.07e-02 13 4 1 0.250 0.077 GO:0051281 BP 1 positive regulation of release of sequestered calcium ion into cytosol 1 P28161 418 1.07e-02 13 4 1 0.250 0.077 GO:1901021 BP 1 positive regulation of calcium ion transmembrane transporter activity 1 P28161 418 1.22e-02 1291 4 3 0.750 0.002 GO:0043167 MF 1 ion binding 1 P21266,Q03013,P28161 418 1.24e-02 15 4 1 0.250 0.067 GO:0071312 BP 1 cellular response to alkaloid 1 P28161 418 1.24e-02 15 4 1 0.250 0.067 GO:0043651 BP 1 linoleic acid metabolic process 1 P28161 418 1.24e-02 15 4 1 0.250 0.067 GO:1903170 BP 1 negative regulation of calcium ion transmembrane transport 1 P28161 418 1.24e-02 15 4 1 0.250 0.067 GO:1901020 BP 1 negative regulation of calcium ion transmembrane transporter activity 1 P28161 418 1.24e-02 15 4 1 0.250 0.067 GO:0010882 BP 1 regulation of cardiac muscle contraction by calcium ion signaling 1 P28161 418 1.32e-02 16 4 1 0.250 0.062 GO:2001258 BP 1 negative regulation of cation channel activity 1 P28161 418 1.32e-02 16 4 1 0.250 0.062 GO:2001259 BP 1 positive regulation of cation channel activity 1 P28161 418 1.32e-02 16 4 1 0.250 0.062 GO:0090280 BP 1 positive regulation of calcium ion import 1 P28161 418 1.32e-02 16 4 1 0.250 0.062 GO:0010880 BP 1 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1 P28161 418 1.33e-02 530 4 3 0.750 0.006 TF:M07247_1 tf 1 Factor: CLOCK; motif: CCACSTGW; match class: 1 1 P46439,Q03013,P28161 418 1.39e-02 52 4 4 1.000 0.077 KEGG:00982 keg 1 Drug metabolism - cytochrome P450 1 P46439,P21266,Q03013,P28161 418 1.40e-02 17 4 1 0.250 0.059 GO:0014808 BP 1 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1 P28161 418 1.40e-02 17 4 1 0.250 0.059 GO:2000272 BP 1 negative regulation of receptor activity 1 P28161 418 1.40e-02 17 4 1 0.250 0.059 GO:0010524 BP 1 positive regulation of calcium ion transport into cytosol 1 P28161 418 1.40e-02 17 4 1 0.250 0.059 GO:1903514 BP 1 calcium ion transport from endoplasmic reticulum to cytosol 1 P28161 418 1.43e-02 1362 4 3 0.750 0.002 GO:0009056 BP 1 catabolic process 1 P21266,Q03013,P28161 418 1.43e-02 259 4 2 0.500 0.008 MI:hsa-miR-191* mi 1 MI:hsa-miR-191* 1 Q03013,P28161 418 1.47e-02 378 4 2 0.500 0.005 GO:1901698 BP 1 response to nitrogen compound 1 P21266,P28161 418 1.48e-02 18 4 1 0.250 0.056 GO:0070296 BP 1 sarcoplasmic reticulum calcium ion transport 1 P28161 418 1.48e-02 18 4 1 0.250 0.056 GO:0060314 BP 1 regulation of ryanodine-sensitive calcium-release channel activity 1 P28161 418 1.48e-02 18 4 1 0.250 0.056 GO:0043627 BP 1 response to estrogen 1 P21266 418 1.57e-02 19 4 1 0.250 0.053 GO:2000273 BP 1 positive regulation of receptor activity 1 P28161 418 1.57e-02 19 4 1 0.250 0.053 GO:0003009 BP 1 skeletal muscle contraction 1 P28161 418 1.62e-02 1423 4 3 0.750 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 P21266,Q03013,P28161 418 1.73e-02 21 4 1 0.250 0.048 GO:1904427 BP 1 positive regulation of calcium ion transmembrane transport 1 P28161 418 1.73e-02 21 4 1 0.250 0.048 GO:0050879 BP 1 multicellular organismal movement 1 P28161 418 1.73e-02 21 4 1 0.250 0.048 GO:0051926 BP 1 negative regulation of calcium ion transport 1 P28161 418 1.73e-02 21 4 1 0.250 0.048 GO:0050881 BP 1 musculoskeletal movement 1 P28161 418 1.76e-02 55 4 4 1.000 0.073 KEGG:00980 keg 1 Metabolism of xenobiotics by cytochrome P450 1 P46439,P21266,Q03013,P28161 418 1.98e-02 24 4 1 0.250 0.042 GO:0007422 BP 1 peripheral nervous system development 1 P21266 418 2.01e-02 3499 4 4 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 P46439,P21266,Q03013,P28161 418 2.18e-02 3569 4 4 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 P46439,P21266,Q03013,P28161 418 2.18e-02 58 4 4 1.000 0.069 KEGG:05204 keg 1 Chemical carcinogenesis 1 P46439,P21266,Q03013,P28161 418 2.23e-02 324 4 2 0.500 0.006 MI:hsa-miR-379* mi 1 MI:hsa-miR-379* 1 Q03013,P28161 418 2.30e-02 28 4 1 0.250 0.036 GO:0032413 BP 1 negative regulation of ion transmembrane transporter activity 1 P28161 418 2.30e-02 28 4 1 0.250 0.036 GO:0043279 BP 1 response to alkaloid 1 P28161 418 2.31e-02 3620 4 4 1.000 0.001 GO:0009058 BP 1 biosynthetic process 1 P46439,P21266,Q03013,P28161 418 2.39e-02 29 4 1 0.250 0.034 GO:0004601 MF 1 peroxidase activity 1 P28161 418 2.39e-02 336 4 2 0.500 0.006 MI:hsa-miR-193b* mi 1 MI:hsa-miR-193b* 1 Q03013,P28161 418 2.47e-02 30 4 1 0.250 0.033 GO:0016529 CC 1 sarcoplasmic reticulum 1 P28161 418 2.47e-02 30 4 1 0.250 0.033 GO:1904063 BP 1 negative regulation of cation transmembrane transport 1 P28161 418 2.52e-02 345 4 2 0.500 0.006 MI:hsa-miR-411* mi 1 MI:hsa-miR-411* 1 Q03013,P28161 418 2.55e-02 31 4 1 0.250 0.032 GO:0016684 MF 1 oxidoreductase activity, acting on peroxide as acceptor 1 P28161 418 2.61e-02 351 4 2 0.500 0.006 MI:gga-miR-456 mi 1 MI:gga-miR-456 1 Q03013,P28161 418 2.71e-02 33 4 1 0.250 0.030 GO:0001885 BP 1 endothelial cell development 1 P21266 418 2.71e-02 33 4 1 0.250 0.030 GO:0016528 CC 1 sarcoplasm 1 P28161 418 2.88e-02 369 4 2 0.500 0.005 MI:hsa-miR-532-3p mi 1 MI:hsa-miR-532-3p 1 Q03013,P28161 418 2.88e-02 35 4 1 0.250 0.029 GO:0051279 BP 1 regulation of release of sequestered calcium ion into cytosol 1 P28161 418 2.88e-02 35 4 1 0.250 0.029 GO:0032410 BP 1 negative regulation of transporter activity 1 P28161 418 2.88e-02 35 4 1 0.250 0.029 GO:0032414 BP 1 positive regulation of ion transmembrane transporter activity 1 P28161 418 2.88e-02 35 4 1 0.250 0.029 GO:0055117 BP 1 regulation of cardiac muscle contraction 1 P28161 418 2.96e-02 36 4 1 0.250 0.028 GO:0051928 BP 1 positive regulation of calcium ion transport 1 P28161 418 2.96e-02 36 4 1 0.250 0.028 GO:0034766 BP 1 negative regulation of ion transmembrane transport 1 P28161 418 3.03e-02 379 4 2 0.500 0.005 MI:hsa-miR-30b* mi 1 MI:hsa-miR-30b* 1 Q03013,P28161 418 3.04e-02 37 4 1 0.250 0.027 GO:0050848 BP 1 regulation of calcium-mediated signaling 1 P28161 418 3.08e-02 382 4 2 0.500 0.005 MI:hsa-miR-92b* mi 1 MI:hsa-miR-92b* 1 Q03013,P28161 418 3.12e-02 38 4 1 0.250 0.026 GO:0034763 BP 1 negative regulation of transmembrane transport 1 P28161 418 3.14e-02 386 4 2 0.500 0.005 MI:hsa-miR-940 mi 1 MI:hsa-miR-940 1 Q03013,P28161 418 3.17e-02 388 4 2 0.500 0.005 MI:mmu-miR-698 mi 1 MI:mmu-miR-698 1 Q03013,P28161 418 3.21e-02 39 4 1 0.250 0.026 GO:1901019 BP 1 regulation of calcium ion transmembrane transporter activity 1 P28161 418 3.27e-02 3948 4 4 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P46439,P21266,Q03013,P28161 418 3.29e-02 40 4 1 0.250 0.025 GO:0010522 BP 1 regulation of calcium ion transport into cytosol 1 P28161 418 3.29e-02 40 4 1 0.250 0.025 GO:1904064 BP 1 positive regulation of cation transmembrane transport 1 P28161 418 3.30e-02 396 4 2 0.500 0.005 MI:mmu-miR-688 mi 1 MI:mmu-miR-688 1 P46439,P28161 418 3.32e-02 2318 4 3 0.750 0.001 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P21266,Q03013,P28161 418 3.35e-02 399 4 2 0.500 0.005 MI:hsa-miR-612 mi 1 MI:hsa-miR-612 1 Q03013,P28161 418 3.37e-02 41 4 1 0.250 0.024 GO:0032411 BP 1 positive regulation of transporter activity 1 P28161 418 3.43e-02 404 4 2 0.500 0.005 MI:hsa-miR-611 mi 1 MI:hsa-miR-611 1 Q03013,P28161 418 3.48e-02 733 4 3 0.750 0.004 TF:M04471_0 tf 1 Factor: NR2E1; motif: AAGTCAANAAGTCA; match class: 0 1 P46439,Q03013,P28161 418 3.51e-02 4019 4 4 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 P46439,P21266,Q03013,P28161 418 3.53e-02 43 4 1 0.250 0.023 GO:0090279 BP 1 regulation of calcium ion import 1 P28161 418 3.61e-02 44 4 1 0.250 0.023 GO:0014074 BP 1 response to purine-containing compound 1 P28161 418 3.63e-02 1882 4 3 0.750 0.002 GO:0042221 BP 1 response to chemical 1 P21266,Q03013,P28161 418 3.65e-02 417 4 2 0.500 0.005 MI:hsa-miR-205 mi 1 MI:hsa-miR-205 1 Q03013,P28161 418 3.69e-02 146 4 2 0.500 0.014 TF:M06731_0 tf 1 Factor: znf302; motif: NGGGCATGSTGM; match class: 0 1 P46439,P28161 418 3.78e-02 46 4 1 0.250 0.022 GO:0006942 BP 1 regulation of striated muscle contraction 1 P28161 418 3.78e-02 46 4 1 0.250 0.022 GO:0016209 MF 1 antioxidant activity 1 P28161 418 3.84e-02 428 4 2 0.500 0.005 MI:hsa-miR-193b mi 1 MI:hsa-miR-193b 1 Q03013,P28161 418 3.84e-02 428 4 2 0.500 0.005 MI:mmu-miR-666-3p mi 1 MI:mmu-miR-666-3p 1 Q03013,P28161 418 3.86e-02 47 4 1 0.250 0.021 GO:0034767 BP 1 positive regulation of ion transmembrane transport 1 P28161 418 3.86e-02 429 4 2 0.500 0.005 MI:hsa-miR-542-5p mi 1 MI:hsa-miR-542-5p 1 Q03013,P28161 418 3.90e-02 431 4 2 0.500 0.005 MI:hsa-miR-483-5p mi 1 MI:hsa-miR-483-5p 1 Q03013,P28161 418 3.93e-02 433 4 2 0.500 0.005 MI:mmu-miR-761 mi 1 MI:mmu-miR-761 1 Q03013,P28161 418 3.93e-02 433 4 2 0.500 0.005 MI:hsa-miR-552 mi 1 MI:hsa-miR-552 1 Q03013,P28161 418 3.97e-02 435 4 2 0.500 0.005 MI:hsa-miR-193a-3p mi 1 MI:hsa-miR-193a-3p 1 Q03013,P28161 418 4.10e-02 50 4 1 0.250 0.020 GO:0051283 BP 1 negative regulation of sequestering of calcium ion 1 P28161 418 4.10e-02 50 4 1 0.250 0.020 GO:0051209 BP 1 release of sequestered calcium ion into cytosol 1 P28161 418 4.10e-02 50 4 1 0.250 0.020 GO:0051282 BP 1 regulation of sequestering of calcium ion 1 P28161 418 4.11e-02 443 4 2 0.500 0.005 MI:hsa-miR-629 mi 1 MI:hsa-miR-629 1 Q03013,P28161 418 4.16e-02 446 4 2 0.500 0.004 MI:mmu-miR-670 mi 1 MI:mmu-miR-670 1 Q03013,P28161 418 4.18e-02 447 4 2 0.500 0.004 MI:hsa-miR-587 mi 1 MI:hsa-miR-587 1 Q03013,P28161 418 4.19e-02 51 4 1 0.250 0.020 GO:0097553 BP 1 calcium ion transmembrane import into cytosol 1 P28161 418 4.19e-02 51 4 1 0.250 0.020 GO:1902656 BP 1 calcium ion import into cytosol 1 P28161 418 4.19e-02 51 4 1 0.250 0.020 GO:0045446 BP 1 endothelial cell differentiation 1 P21266 418 4.22e-02 449 4 2 0.500 0.004 MI:hsa-miR-602 mi 1 MI:hsa-miR-602 1 Q03013,P28161 418 4.27e-02 52 4 1 0.250 0.019 GO:0034764 BP 1 positive regulation of transmembrane transport 1 P28161 418 4.27e-02 52 4 1 0.250 0.019 GO:0043271 BP 1 negative regulation of ion transport 1 P28161 418 4.27e-02 52 4 1 0.250 0.019 GO:1903169 BP 1 regulation of calcium ion transmembrane transport 1 P28161 418 4.29e-02 453 4 2 0.500 0.004 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 Q03013,P28161 418 4.35e-02 53 4 1 0.250 0.019 GO:0051208 BP 1 sequestering of calcium ion 1 P28161 418 4.44e-02 461 4 2 0.500 0.004 MI:hsa-miR-589 mi 1 MI:hsa-miR-589 1 Q03013,P28161 418 4.44e-02 4264 4 4 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P46439,P21266,Q03013,P28161 418 4.50e-02 464 4 2 0.500 0.004 MI:hsa-miR-575 mi 1 MI:hsa-miR-575 1 Q03013,P28161 418 4.51e-02 55 4 1 0.250 0.018 GO:2001257 BP 1 regulation of cation channel activity 1 P28161 418 4.59e-02 56 4 1 0.250 0.018 GO:0001676 BP 1 long-chain fatty acid metabolic process 1 P28161 418 4.61e-02 470 4 2 0.500 0.004 MI:mmu-miR-710 mi 1 MI:mmu-miR-710 1 Q03013,P28161 418 4.67e-02 57 4 1 0.250 0.018 GO:0060048 BP 1 cardiac muscle contraction 1 P28161 418 4.78e-02 479 4 2 0.500 0.004 MI:hsa-miR-342-3p mi 1 MI:hsa-miR-342-3p 1 Q03013,P28161 418 4.92e-02 60 4 1 0.250 0.017 GO:0060402 BP 1 calcium ion transport into cytosol 1 P28161 418 4.92e-02 486 4 2 0.500 0.004 MI:hsa-miR-34c-3p mi 1 MI:hsa-miR-34c-3p 1 Q03013,P28161 418 5.00e-02 2290 4 4 1.000 0.002 TF:M07347_0 tf 1 Factor: AhR; motif: NNNKNGCGTGNSNNNNN; match class: 0 1 P46439,P21266,Q03013,P28161 418 5.00e-02 1718 4 4 1.000 0.002 REAC:1430728 rea 1 Metabolism 1 P46439,P21266,Q03013,P28161 418 5.00e-02 61 4 1 0.250 0.016 GO:0003158 BP 1 endothelium development 1 P21266 418 5.00e-02 490 4 2 0.500 0.004 MI:hsa-miR-34b mi 1 MI:hsa-miR-34b 1 Q03013,P28161 418 5.00e-02 71 4 4 1.000 0.056 KEGG:01524 keg 1 Platinum drug resistance 1 P46439,P21266,Q03013,P28161 419 3.18e-03 8 2 1 0.500 0.125 REAC:71384 rea 1 Ethanol oxidation 1 P30837 419 5.09e-03 2 2 1 0.500 0.500 GO:0045041 BP 1 protein import into mitochondrial intermembrane space 1 Q9Y4W6 419 1.00e-02 1 2 1 0.500 1.000 OMIM:614487 omi 1 SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE; SPAX5 1 Q9Y4W6 419 1.00e-02 1 2 1 0.500 1.000 OMIM:610246 omi 1 SPINOCEREBELLAR ATAXIA 28; SCA28 1 Q9Y4W6 419 1.35e-02 1254 2 2 1.000 0.002 HPA:023020_03 hpa 1 lymph node; non-germinal center cells[Uncertain,High] 1 P30837,Q9Y4W6 419 1.46e-02 18 2 1 0.500 0.056 KEGG:00340 keg 1 Histidine metabolism 1 P30837 419 1.53e-02 6 2 1 0.500 0.167 GO:0004176 MF 1 ATP-dependent peptidase activity 1 Q9Y4W6 419 1.58e-02 6 2 1 0.500 0.167 HP:0002497 hp 1 Spastic ataxia 1 Q9Y4W6 419 1.62e-02 20 2 1 0.500 0.050 KEGG:00053 keg 1 Ascorbate and aldarate metabolism 1 P30837 419 1.78e-02 7 2 1 0.500 0.143 GO:0034982 BP 1 mitochondrial protein processing 1 Q9Y4W6 419 1.78e-02 45 2 1 0.500 0.022 REAC:211945 rea 1 Phase 1 - Functionalization of compounds 1 P30837 419 1.90e-02 1488 2 2 1.000 0.001 HPA:022010_03 hpa 1 lung; macrophages[Uncertain,High] 1 P30837,Q9Y4W6 419 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 P30837,Q9Y4W6 419 2.03e-02 8 2 1 0.500 0.125 GO:0006069 BP 1 ethanol oxidation 1 P30837 419 2.03e-02 8 2 1 0.500 0.125 GO:0036444 BP 1 mitochondrial calcium uptake 1 Q9Y4W6 419 2.03e-02 8 2 1 0.500 0.125 GO:0006067 BP 1 ethanol metabolic process 1 P30837 419 2.10e-02 26 2 1 0.500 0.038 KEGG:00410 keg 1 beta-Alanine metabolism 1 P30837 419 2.15e-02 1583 2 2 1.000 0.001 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 P30837,Q9Y4W6 419 2.29e-02 9 2 1 0.500 0.111 GO:0042407 BP 1 cristae formation 1 Q9Y4W6 419 2.43e-02 30 2 1 0.500 0.033 KEGG:00380 keg 1 Tryptophan metabolism 1 P30837 419 2.80e-02 11 2 1 0.500 0.091 GO:0006851 BP 1 mitochondrial calcium ion transport 1 Q9Y4W6 419 3.06e-02 446 2 2 1.000 0.004 TF:M07265_1 tf 1 Factor: Nrf2; motif: NNTGACTCAGCAN; match class: 1 1 P30837,Q9Y4W6 419 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 P30837,Q9Y4W6 419 3.07e-02 38 2 1 0.500 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P30837 419 3.07e-02 38 2 1 0.500 0.026 KEGG:00071 keg 1 Fatty acid degradation 1 P30837 419 3.47e-02 43 2 1 0.500 0.023 KEGG:00330 keg 1 Arginine and proline metabolism 1 P30837 419 3.56e-02 14 2 1 0.500 0.071 GO:0051560 BP 1 mitochondrial calcium ion homeostasis 1 Q9Y4W6 419 3.56e-02 14 2 1 0.500 0.071 GO:0007007 BP 1 inner mitochondrial membrane organization 1 Q9Y4W6 419 3.72e-02 46 2 1 0.500 0.022 KEGG:00280 keg 1 Valine, leucine and isoleucine degradation 1 P30837 419 3.88e-02 48 2 1 0.500 0.021 KEGG:00561 keg 1 Glycerolipid metabolism 1 P30837 419 3.92e-02 10 2 1 0.500 0.100 TF:M05784_0 tf 1 Factor: ZNF699; motif: NTGRGCTTCCGM; match class: 0 1 Q9Y4W6 419 4.07e-02 2177 2 2 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 P30837,Q9Y4W6 419 4.21e-02 16 2 1 0.500 0.062 HP:0012240 hp 1 Increased intramyocellular lipid droplets 1 Q9Y4W6 419 4.32e-02 17 2 1 0.500 0.059 GO:0021675 BP 1 nerve development 1 Q9Y4W6 419 4.32e-02 17 2 1 0.500 0.059 GO:0004029 MF 1 aldehyde dehydrogenase (NAD) activity 1 P30837 419 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 P30837,Q9Y4W6 419 4.44e-02 55 2 1 0.500 0.018 KEGG:00310 keg 1 Lysine degradation 1 P30837 419 4.74e-02 18 2 1 0.500 0.056 HP:0000641 hp 1 Dysmetric saccades 1 Q9Y4W6 419 5.00e-02 127 2 1 0.500 0.008 REAC:211859 rea 1 Biological oxidations 1 P30837 419 5.00e-02 19 2 1 0.500 0.053 HP:0007141 hp 1 Sensorimotor neuropathy 1 Q9Y4W6 419 5.00e-02 570 2 2 1.000 0.004 TF:M02022_0 tf 1 Factor: MafK; motif: TGASTCAGCDN; match class: 0 1 P30837,Q9Y4W6 419 5.00e-02 62 2 1 0.500 0.016 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P30837 419 5.00e-02 674 2 2 1.000 0.003 GO:0044429 CC 1 mitochondrial part 1 P30837,Q9Y4W6 419 5.00e-02 19 2 1 0.500 0.053 HP:0009058 hp 1 Increased muscle lipid content 1 Q9Y4W6 419 5.00e-02 5 2 1 0.500 0.200 OMIM:108600 omi 1 Spastic Ataxia 1 Q9Y4W6 420 8.15e-04 306 3 3 1.000 0.010 GO:0015629 CC 1 actin cytoskeleton 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.03e-03 942 3 3 1.000 0.003 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.60e-03 1091 3 3 1.000 0.003 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.19e-03 1372 3 3 1.000 0.002 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.36e-03 1396 3 3 1.000 0.002 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.77e-03 16 3 1 0.333 0.062 TF:M06535_0 tf 1 Factor: ZNF555; motif: KGGGGCTGCCGN; match class: 0 1 Q6WCQ1 420 4.00e-03 17 3 1 0.333 0.059 TF:M05718_0 tf 1 Factor: ZNF30; motif: NGGTTAAGAYRC; match class: 0 1 Q6WCQ1 420 5.24e-03 1619 3 3 1.000 0.002 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.27e-03 1622 3 3 1.000 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 6.97e-03 1780 3 3 1.000 0.002 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 7.23e-03 1802 3 3 1.000 0.002 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 7.29e-03 31 3 1 0.333 0.032 TF:M05878_0 tf 1 Factor: ZNF100; motif: NTGGWGGGCGGA; match class: 0 1 Q9P0K7 420 8.21e-03 1880 3 3 1.000 0.002 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 8.28e-03 1885 3 3 1.000 0.002 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 8.80e-03 1924 3 3 1.000 0.002 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 8.93e-03 1933 3 3 1.000 0.002 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 9.81e-03 743 3 2 0.667 0.003 TF:M05381_0 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 0 1 Q9P0K7,Q6WCQ1 420 9.86e-03 1998 3 3 1.000 0.002 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.02e-02 2024 3 3 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.03e-02 2026 3 3 1.000 0.001 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.05e-02 2043 3 3 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.09e-02 785 3 2 0.667 0.003 TF:M05319_0 tf 1 Factor: KLF7; motif: NGGGCGGGGG; match class: 0 1 Q9P0K7,Q6WCQ1 420 1.09e-02 785 3 2 0.667 0.003 TF:M05318_0 tf 1 Factor: KLF8; motif: NGGGCGGGGG; match class: 0 1 Q9P0K7,Q6WCQ1 420 1.10e-02 2071 3 3 1.000 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.13e-02 2855 3 3 1.000 0.001 TF:M00955_0 tf 1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 0 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.13e-02 2092 3 3 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.16e-02 2110 3 3 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.18e-02 2119 3 3 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.21e-02 2139 3 3 1.000 0.001 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.21e-02 2139 3 3 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.23e-02 2153 3 3 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.24e-02 2154 3 3 1.000 0.001 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.27e-02 54 3 1 0.333 0.019 TF:M03884_1 tf 1 Factor: Rev-ErbAaLPHA; motif: NYTGACCTANTTA; match class: 1 1 Q6WCQ1 420 1.29e-02 2188 3 3 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.32e-02 2202 3 3 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.33e-02 868 3 2 0.667 0.002 TF:M03838_0 tf 1 Factor: Otx1; motif: WASTAATCC; match class: 0 1 Q9H2D6,Q6WCQ1 420 1.37e-02 2227 3 3 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.38e-02 59 3 1 0.333 0.017 TF:M06072_0 tf 1 Factor: ZNF623; motif: KGGGGAAGMTGM; match class: 0 1 Q6WCQ1 420 1.42e-02 608 3 2 0.667 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q9H2D6,Q6WCQ1 420 1.45e-02 2274 3 3 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.45e-02 2274 3 3 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.45e-02 62 3 1 0.333 0.016 TF:M06179_0 tf 1 Factor: ZNF445; motif: NGGATAAAGGA; match class: 0 1 Q9P0K7 420 1.46e-02 2276 3 3 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.47e-02 2281 3 3 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.48e-02 2286 3 3 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.48e-02 2290 3 3 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.52e-02 2308 3 3 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.52e-02 2310 3 3 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.53e-02 932 3 2 0.667 0.002 TF:M05432_1 tf 1 Factor: ZSCAN18; motif: TRRCGRCGNMCC; match class: 1 1 Q9P0K7,Q6WCQ1 420 1.56e-02 2328 3 3 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.57e-02 639 3 2 0.667 0.003 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 Q9H2D6,Q6WCQ1 420 1.59e-02 2342 3 3 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.64e-02 2366 3 3 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.68e-02 2385 3 3 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.70e-02 2395 3 3 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.75e-02 2417 3 3 1.000 0.001 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.76e-02 2425 3 3 1.000 0.001 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.77e-02 2429 3 3 1.000 0.001 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.79e-02 2435 3 3 1.000 0.001 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.83e-02 2456 3 3 1.000 0.001 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.86e-02 2469 3 3 1.000 0.001 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.87e-02 2472 3 3 1.000 0.001 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 1.94e-02 2505 3 3 1.000 0.001 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 2.02e-02 296 3 2 0.667 0.007 MI:hsa-miR-194* mi 1 MI:hsa-miR-194* 1 Q9H2D6,Q6WCQ1 420 2.04e-02 2547 3 3 1.000 0.001 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 2.06e-02 88 3 1 0.333 0.011 TF:M06440_0 tf 1 Factor: ZNF493; motif: KGGGAAKAAGGA; match class: 0 1 Q6WCQ1 420 2.11e-02 2574 3 3 1.000 0.001 HPA:039040_10 hpa 1 soft tissue 1; peripheral nerve[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 2.29e-02 2 3 1 0.333 0.500 GO:0030047 BP 1 actin modification 1 Q9H2D6 420 2.57e-02 110 3 1 0.333 0.009 TF:M02252_1 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 1 1 Q9P0K7 420 2.59e-02 111 3 1 0.333 0.009 TF:M06003_0 tf 1 Factor: ZNF257; motif: NTGGWGGGCAKM; match class: 0 1 Q6WCQ1 420 2.60e-02 1225 3 2 0.667 0.002 TF:M00807_1 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 1 Q9H2D6,Q6WCQ1 420 2.66e-02 114 3 1 0.333 0.009 TF:M01774_1 tf 1 Factor: TBR2; motif: AGGTGTGAA; match class: 1 1 Q9H2D6 420 2.69e-02 115 3 1 0.333 0.009 TF:M07079_0 tf 1 Factor: Cdx-2; motif: NNGYMATAAAA; match class: 0 1 Q9P0K7 420 2.73e-02 2805 3 3 1.000 0.001 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 2.83e-02 2839 3 3 1.000 0.001 HPA:029010_10 hpa 1 placenta; decidual cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.01e-02 362 3 2 0.667 0.006 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 Q9H2D6,Q6WCQ1 420 3.06e-02 2914 3 3 1.000 0.001 HPA:040040_10 hpa 1 soft tissue 2; peripheral nerve[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.17e-02 136 3 1 0.333 0.007 TF:M00157_1 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 1 1 Q6WCQ1 420 3.29e-02 4080 3 3 1.000 0.001 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.33e-02 2 3 1 0.333 0.500 CORUM:816 cor 1 MRIP-RHOA complex 1 Q6WCQ1 420 3.33e-02 2 3 1 0.333 0.500 CORUM:817 cor 1 MRIP-MBS complex 1 Q6WCQ1 420 3.38e-02 145 3 1 0.333 0.007 TF:M00978_1 tf 1 Factor: LEF-1,; motif: MCTTTGWTSNY; match class: 1 1 Q9P0K7 420 3.49e-02 3045 3 3 1.000 0.001 HPA:009030_10 hpa 1 colon; peripheral nerve/ganglion[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.56e-02 4187 3 3 1.000 0.001 TF:M00712_1 tf 1 Factor: myogenin; motif: RGCAGSTG; match class: 1 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.70e-02 159 3 1 0.333 0.006 TF:M01248_1 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 1 1 Q9H2D6 420 3.71e-02 1473 3 2 0.667 0.001 TF:M01142_0 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 0 1 Q9H2D6,Q6WCQ1 420 3.84e-02 165 3 1 0.333 0.006 TF:M02252_0 tf 1 Factor: EWSR1-FLI1; motif: GGAAGGAAGGAAGGAAGG; match class: 0 1 Q9P0K7 420 3.85e-02 1502 3 2 0.667 0.001 TF:M01783_0 tf 1 Factor: SP2; motif: GGGCGGGAC; match class: 0 1 Q9P0K7,Q6WCQ1 420 3.95e-02 170 3 1 0.333 0.006 TF:M06125_0 tf 1 Factor: ZNF823; motif: NGRGGGAGGAGG; match class: 0 1 Q9P0K7 420 3.97e-02 4343 3 3 1.000 0.001 TF:M00807_0 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 0 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 3.98e-02 171 3 1 0.333 0.006 TF:M00002_1 tf 1 Factor: E47; motif: VSNGCAGGTGKNCNN; match class: 1 1 Q9H2D6 420 4.00e-02 172 3 1 0.333 0.006 TF:M07351_1 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 1 1 Q9H2D6 420 4.08e-02 3208 3 3 1.000 0.001 HPA:039010_10 hpa 1 soft tissue 1; adipocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.11e-02 177 3 1 0.333 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q6WCQ1 420 4.13e-02 425 3 2 0.667 0.005 MI:mmu-miR-344 mi 1 MI:mmu-miR-344 1 Q9P0K7,Q6WCQ1 420 4.17e-02 1567 3 2 0.667 0.001 TF:M07361_0 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 0 1 Q9P0K7,Q6WCQ1 420 4.23e-02 3247 3 3 1.000 0.001 HPA:008020_10 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.33e-02 1598 3 2 0.667 0.001 TF:M07049_0 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 0 1 Q9P0K7,Q6WCQ1 420 4.35e-02 436 3 2 0.667 0.005 MI:hsa-miR-122 mi 1 MI:hsa-miR-122 1 Q9H2D6,Q6WCQ1 420 4.35e-02 4478 3 3 1.000 0.001 TF:M00468_1 tf 1 Factor: AP-2rep; motif: CAGTGGG; match class: 1 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.55e-02 3326 3 3 1.000 0.001 HPA:023010_10 hpa 1 lymph node; germinal center cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.58e-02 4 3 1 0.333 0.250 GO:0045159 MF 1 myosin II binding 1 Q9H2D6 420 4.58e-02 3334 3 3 1.000 0.001 HPA:040010_10 hpa 1 soft tissue 2; adipocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.59e-02 4559 3 3 1.000 0.001 TF:M07409_0 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 0 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.62e-02 42 3 1 0.333 0.024 HP:0008625 hp 1 Severe sensorineural hearing impairment 1 Q9H2D6 420 4.62e-02 42 3 1 0.333 0.024 HP:0000399 hp 1 Prelingual sensorineural hearing impairment 1 Q9H2D6 420 4.62e-02 42 3 1 0.333 0.024 HP:0004463 hp 1 Absent brainstem auditory responses 1 Q9H2D6 420 4.62e-02 42 3 1 0.333 0.024 HP:0012714 hp 1 Severe hearing impairment 1 Q9H2D6 420 4.63e-02 3344 3 3 1.000 0.001 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.63e-02 3344 3 3 1.000 0.001 HPA:027020_10 hpa 1 pancreas; islets of Langerhans[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.64e-02 4573 3 3 1.000 0.001 TF:M00138_0 tf 1 Factor: Oct-1; motif: NNNNNNNWATGCAAATNNNWNNA; match class: 0 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.67e-02 3355 3 3 1.000 0.001 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.69e-02 202 3 1 0.333 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 Q6WCQ1 420 4.70e-02 3361 3 3 1.000 0.001 HPA:039030_10 hpa 1 soft tissue 1; fibroblasts[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.73e-02 3368 3 3 1.000 0.001 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.73e-02 43 3 1 0.333 0.023 HP:0008568 hp 1 Vestibular areflexia 1 Q9H2D6 420 4.73e-02 43 3 1 0.333 0.023 HP:0012715 hp 1 Profound hearing impairment 1 Q9H2D6 420 4.73e-02 43 3 1 0.333 0.023 HP:0011387 hp 1 Enlarged vestibular aqueduct 1 Q9H2D6 420 4.73e-02 43 3 1 0.333 0.023 HP:0011476 hp 1 Profound sensorineural hearing impairment 1 Q9H2D6 420 4.73e-02 3370 3 3 1.000 0.001 HPA:002020_10 hpa 1 appendix; lymphoid tissue[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.75e-02 205 3 1 0.333 0.005 TF:M07376_1 tf 1 Factor: beta-catenin; motif: CTTTGWTN; match class: 1 1 Q9P0K7 420 4.77e-02 3379 3 3 1.000 0.001 HPA:005010_10 hpa 1 bronchus; respiratory epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.79e-02 4622 3 3 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.80e-02 1135 3 2 0.667 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q9H2D6,Q6WCQ1 420 4.80e-02 3386 3 3 1.000 0.001 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.80e-02 3386 3 3 1.000 0.001 HPA:040030_10 hpa 1 soft tissue 2; fibroblasts[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.80e-02 3386 3 3 1.000 0.001 HPA:009010_10 hpa 1 colon; endothelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.81e-02 459 3 2 0.667 0.004 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q9P0K7,Q6WCQ1 420 4.82e-02 3390 3 3 1.000 0.001 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.82e-02 1690 3 2 0.667 0.001 TF:M03802_1 tf 1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 1 Q9H2D6,Q6WCQ1 420 4.83e-02 44 3 1 0.333 0.023 HP:0011376 hp 1 Morphological abnormality of the vestibule of the inner ear 1 Q9H2D6 420 4.83e-02 44 3 1 0.333 0.023 HP:0007670 hp 1 Abnormal vestibulo-ocular reflex 1 Q9H2D6 420 4.87e-02 3403 3 3 1.000 0.001 HPA:035020_10 hpa 1 skin 1; fibroblasts[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.88e-02 3405 3 3 1.000 0.001 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.89e-02 3407 3 3 1.000 0.001 HPA:036010_10 hpa 1 skin 2; epidermal cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.89e-02 3407 3 3 1.000 0.001 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.91e-02 3412 3 3 1.000 0.001 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.92e-02 3413 3 3 1.000 0.001 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.93e-02 3415 3 3 1.000 0.001 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.93e-02 3416 3 3 1.000 0.001 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.93e-02 3416 3 3 1.000 0.001 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.93e-02 3416 3 3 1.000 0.001 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.94e-02 3418 3 3 1.000 0.001 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.94e-02 45 3 1 0.333 0.022 HP:0001756 hp 1 Vestibular hypofunction 1 Q9H2D6 420 4.95e-02 3420 3 3 1.000 0.001 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.95e-02 3421 3 3 1.000 0.001 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.96e-02 3422 3 3 1.000 0.001 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.96e-02 3422 3 3 1.000 0.001 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.96e-02 3423 3 3 1.000 0.001 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.96e-02 3423 3 3 1.000 0.001 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.97e-02 3424 3 3 1.000 0.001 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.97e-02 3426 3 3 1.000 0.001 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.97e-02 3426 3 3 1.000 0.001 HPA:006010_10 hpa 1 cerebellum; Purkinje cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.98e-02 3428 3 3 1.000 0.001 HPA:007010_10 hpa 1 cerebral cortex; endothelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.99e-02 3429 3 3 1.000 0.001 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.99e-02 3429 3 3 1.000 0.001 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.99e-02 3429 3 3 1.000 0.001 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 4.99e-02 3430 3 3 1.000 0.001 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3431 3 3 1.000 0.001 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 1204 3 3 1.000 0.002 GO:0005856 CC 1 cytoskeleton 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3 3 1 0.333 0.333 CORUM:815 cor 1 MRIP-MBS-RHOA complex 1 Q6WCQ1 420 5.00e-02 468 3 2 0.667 0.004 MI:hsa-miR-449a mi 1 MI:hsa-miR-449a 1 Q9P0K7,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 1 3 1 0.333 1.000 OMIM:609823 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 28; DFNB28 1 Q9H2D6 420 5.00e-02 3432 3 3 1.000 0.001 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 420 5.00e-02 3432 3 3 1.000 0.001 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 Q9P0K7,Q9H2D6,Q6WCQ1 421 1.93e-03 1 2 1 0.500 1.000 GO:0006436 BP 1 tryptophanyl-tRNA aminoacylation 1 P23381 421 2.67e-03 17 2 1 0.500 0.059 TF:M05509_1 tf 1 Factor: ZAC; motif: KGGGGAAGAA; match class: 1 1 P23381 421 2.94e-03 188 2 2 1.000 0.011 GO:0001525 BP 1 angiogenesis 1 Q92823,P23381 421 3.30e-03 21 2 1 0.500 0.048 TF:M06139_0 tf 1 Factor: ZNF324; motif: NCTGGMATGGGM; match class: 0 1 P23381 421 3.30e-03 21 2 1 0.500 0.048 TF:M03978_0 tf 1 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN; match class: 0 1 P23381 421 3.79e-03 7 2 1 0.500 0.143 REAC:447038 rea 1 NrCAM interactions 1 Q92823 421 3.79e-03 7 2 1 0.500 0.143 REAC:447043 rea 1 Neurofascin interactions 1 Q92823 421 3.86e-03 2 2 1 0.500 0.500 GO:0004830 MF 1 tryptophan-tRNA ligase activity 1 P23381 421 4.06e-03 221 2 2 1.000 0.009 GO:0048514 BP 1 blood vessel morphogenesis 1 Q92823,P23381 421 4.40e-03 28 2 1 0.500 0.036 TF:M06940_0 tf 1 Factor: ATF-3; motif: TCTATGTAATMW; match class: 0 1 Q92823 421 4.71e-03 238 2 2 1.000 0.008 GO:0001568 BP 1 blood vessel development 1 Q92823,P23381 421 4.96e-03 244 2 2 1.000 0.008 GO:0001944 BP 1 vasculature development 1 Q92823,P23381 421 5.04e-03 246 2 2 1.000 0.008 GO:0072358 BP 1 cardiovascular system development 1 Q92823,P23381 421 5.78e-03 3 2 1 0.500 0.333 GO:0045162 BP 1 clustering of voltage-gated sodium channels 1 Q92823 421 6.75e-03 1046 2 2 1.000 0.002 TF:M00262_0 tf 1 Factor: Staf; motif: NTTWCCCANMATGCAYYRCGNY; match class: 0 1 Q92823,P23381 421 7.69e-03 49 2 1 0.500 0.020 TF:M06070_0 tf 1 Factor: ZNF732; motif: NGTTGCATCATM; match class: 0 1 P23381 421 8.00e-03 51 2 1 0.500 0.020 TF:M06391_0 tf 1 Factor: ZNF836; motif: NGGGGYTCCAGM; match class: 0 1 Q92823 421 8.54e-03 1177 2 2 1.000 0.002 TF:M05546_0 tf 1 Factor: EOS; motif: TGGTTATM; match class: 0 1 Q92823,P23381 421 9.41e-03 60 2 1 0.500 0.017 TF:M07311_1 tf 1 Factor: STAT5A; motif: TTCYYRGAAAN; match class: 1 1 P23381 421 1.15e-02 372 2 2 1.000 0.005 GO:0072359 BP 1 circulatory system development 1 Q92823,P23381 421 1.22e-02 382 2 2 1.000 0.005 GO:0048646 BP 1 anatomical structure formation involved in morphogenesis 1 Q92823,P23381 421 1.30e-02 24 2 1 0.500 0.042 REAC:379716 rea 1 Cytosolic tRNA aminoacylation 1 P23381 421 1.32e-02 84 2 1 0.500 0.012 TF:M07045_1 tf 1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 1 P23381 421 1.35e-02 7 2 1 0.500 0.143 GO:0043194 CC 1 axon initial segment 1 Q92823 421 1.35e-02 25 2 1 0.500 0.040 REAC:445095 rea 1 Interaction between L1 and Ankyrins 1 Q92823 421 1.35e-02 1482 2 2 1.000 0.001 TF:M04002_0 tf 1 Factor: GCMb; motif: NATGCGGGTN; match class: 0 1 Q92823,P23381 421 1.53e-02 98 2 1 0.500 0.010 TF:M03947_1 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 1 1 Q92823 421 1.54e-02 8 2 1 0.500 0.125 GO:0045161 BP 1 neuronal ion channel clustering 1 Q92823 421 1.56e-02 1588 2 2 1.000 0.001 TF:M03796_1 tf 1 Factor: MafA; motif: GGTCAGCAGH; match class: 1 1 Q92823,P23381 421 1.80e-02 115 2 1 0.500 0.009 TF:M03947_0 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 0 1 Q92823 421 2.10e-02 1847 2 2 1.000 0.001 TF:M07290_1 tf 1 Factor: GLI; motif: NGACCMCCCAN; match class: 1 1 Q92823,P23381 421 2.22e-02 1897 2 2 1.000 0.001 TF:M00249_0 tf 1 Factor: CHOP:C/EBPalpha; motif: NNRTGCAATMCCC; match class: 0 1 Q92823,P23381 421 2.27e-02 42 2 1 0.500 0.024 REAC:379724 rea 1 tRNA Aminoacylation 1 P23381 421 2.28e-02 523 2 2 1.000 0.004 GO:0022603 BP 1 regulation of anatomical structure morphogenesis 1 Q92823,P23381 421 2.31e-02 12 2 1 0.500 0.083 GO:0007413 BP 1 axonal fasciculation 1 Q92823 421 2.85e-02 2151 2 2 1.000 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 Q92823,P23381 421 2.89e-02 15 2 1 0.500 0.067 GO:0042551 BP 1 neuron maturation 1 Q92823 421 2.98e-02 191 2 1 0.500 0.005 TF:M07217_0 tf 1 Factor: MAX; motif: RRGCACATGK; match class: 0 1 P23381 421 3.12e-02 200 2 1 0.500 0.005 TF:M01752_1 tf 1 Factor: ERG; motif: ACCGGAART; match class: 1 1 P23381 421 3.16e-02 203 2 1 0.500 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 P23381 421 3.27e-02 17 2 1 0.500 0.059 GO:0030506 MF 1 ankyrin binding 1 Q92823 421 3.35e-02 215 2 1 0.500 0.005 TF:M03948_1 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 1 Q92823 421 3.37e-02 216 2 1 0.500 0.005 TF:M02062_1 tf 1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 1 P23381 421 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 Q92823,P23381 421 3.87e-02 249 2 1 0.500 0.004 TF:M00405_1 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 1 1 P23381 421 3.91e-02 251 2 1 0.500 0.004 TF:M01066_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN; match class: 0 1 P23381 421 3.92e-02 252 2 1 0.500 0.004 TF:M01220_0 tf 1 Factor: STAT3:STAT3; motif: TTKMCGGGAAMTSC; match class: 0 1 P23381 421 3.94e-02 253 2 1 0.500 0.004 TF:M05498_0 tf 1 Factor: DRRS; motif: NGTAGTCAGC; match class: 0 1 P23381 421 3.95e-02 254 2 1 0.500 0.004 TF:M01876_1 tf 1 Factor: GABPbeta; motif: ASMGGAAGKGN; match class: 1 1 P23381 421 4.04e-02 21 2 1 0.500 0.048 GO:0008038 BP 1 neuron recognition 1 Q92823 421 4.06e-02 261 2 1 0.500 0.004 TF:M04187_1 tf 1 Factor: OLIG3; motif: AMCATATGNY; match class: 1 1 P23381 421 4.27e-02 2630 2 2 1.000 0.001 TF:M03574_0 tf 1 Factor: GCMa; motif: CCCGCAT; match class: 0 1 Q92823,P23381 421 4.30e-02 2641 2 2 1.000 0.001 TF:M00947_0 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 0 1 Q92823,P23381 421 4.33e-02 2649 2 2 1.000 0.001 TF:M04632_1 tf 1 Factor: SREBP-1; motif: NNNGTGGGGTGAN; match class: 1 1 Q92823,P23381 421 4.62e-02 24 2 1 0.500 0.042 GO:0044304 CC 1 main axon 1 Q92823 421 4.86e-02 313 2 1 0.500 0.003 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 P23381 421 4.92e-02 317 2 1 0.500 0.003 TF:M03982_1 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 1 P23381 421 5.00e-02 44 2 1 0.500 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 P23381 421 5.00e-02 93 2 1 0.500 0.011 REAC:373760 rea 1 L1CAM interactions 1 Q92823 421 5.00e-02 252 2 2 1.000 0.008 MI:hsa-miR-130b* mi 1 MI:hsa-miR-130b* 1 Q92823,P23381 421 5.00e-02 774 2 2 1.000 0.003 GO:2000026 BP 1 regulation of multicellular organismal development 1 Q92823,P23381 422 2.18e-03 464 7 3 0.429 0.006 MI:hsa-miR-575 mi 1 MI:hsa-miR-575 1 Q12891,P00533,P54289 422 3.90e-03 1 7 1 0.143 1.000 OMIM:616069 omi 1 INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2; NISBD2 1 P00533 422 7.79e-03 2 7 1 0.143 0.500 OMIM:614328 omi 1 Neonatal Inflammatory Skin and Bowel Disease 1 P00533 422 8.40e-03 51 7 2 0.286 0.039 GO:0042307 BP 1 positive regulation of protein import into nucleus 1 Q12891,P00533 422 8.43e-03 2 7 1 0.143 0.500 HP:0100501 hp 1 Recurrent bronchiolitis 1 P00533 422 8.74e-03 52 7 2 0.286 0.038 GO:1904591 BP 1 positive regulation of protein import 1 Q12891,P00533 422 1.16e-02 60 7 2 0.286 0.033 GO:0051896 BP 1 regulation of protein kinase B signaling 1 Q12891,P00533 422 1.17e-02 3 7 1 0.143 0.333 OMIM:191830 omi 1 Renal Hypodysplasia/Aplasia 1 P53708 422 1.29e-02 1 7 1 0.143 1.000 GO:0030294 MF 1 receptor signaling protein tyrosine kinase inhibitor activity 1 Q12891 422 1.29e-02 1 7 1 0.143 1.000 GO:0032431 BP 1 activation of phospholipase A2 activity 1 P00533 422 1.29e-02 1 7 1 0.143 1.000 GO:0070295 BP 1 renal water absorption 1 Q12891 422 1.29e-02 1 7 1 0.143 1.000 GO:0043006 BP 1 activation of phospholipase A2 activity by calcium-mediated signaling 1 P00533 422 1.29e-02 1 7 1 0.143 1.000 GO:1901387 BP 1 positive regulation of voltage-gated calcium channel activity 1 P54289 422 1.29e-02 1 7 1 0.143 1.000 GO:0033906 MF 1 hyaluronoglucuronidase activity 1 Q12891 422 1.29e-02 1 7 1 0.143 1.000 GO:0016232 MF 1 HNK-1 sulfotransferase activity 1 O43529 422 1.29e-02 1 7 1 0.143 1.000 GO:0097489 CC 1 multivesicular body, internal vesicle lumen 1 P00533 422 1.29e-02 1 7 1 0.143 1.000 GO:1901843 BP 1 positive regulation of high voltage-gated calcium channel activity 1 P54289 422 1.29e-02 1 7 1 0.143 1.000 GO:0005006 MF 1 epidermal growth factor-activated receptor activity 1 P00533 422 1.33e-02 311 7 3 0.429 0.010 GO:0009986 CC 1 cell surface 1 Q12891,P53708,P00533 422 1.37e-02 65 7 2 0.286 0.031 GO:0046824 BP 1 positive regulation of nucleocytoplasmic transport 1 Q12891,P00533 422 1.45e-02 67 7 2 0.286 0.030 GO:0043491 BP 1 protein kinase B signaling 1 Q12891,P00533 422 1.62e-02 333 7 3 0.429 0.009 GO:0005924 CC 1 cell-substrate adherens junction 1 P53708,P00533,Q96KR4 422 1.62e-02 333 7 3 0.429 0.009 GO:0005925 CC 1 focal adhesion 1 P53708,P00533,Q96KR4 422 1.67e-02 72 7 2 0.286 0.028 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 Q12891,P00533 422 1.68e-02 337 7 3 0.429 0.009 GO:0030055 CC 1 cell-substrate junction 1 P53708,P00533,Q96KR4 422 1.96e-02 362 7 2 0.286 0.006 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 Q12891,P00533 422 2.38e-02 86 7 2 0.286 0.023 GO:0001822 BP 1 kidney development 1 Q12891,P53708 422 2.47e-02 409 7 2 0.286 0.005 MI:hsa-miR-375 mi 1 MI:hsa-miR-375 1 Q12891,P00533 422 2.51e-02 2 7 1 0.143 0.500 CORUM:2439 cor 1 ITGA8-ITGB1 complex 1 P53708 422 2.52e-02 6 7 1 0.143 0.167 HP:0002009 hp 1 Potter facies 1 P53708 422 2.52e-02 6 7 1 0.143 0.167 HP:0011334 hp 1 Facial shape deformation 1 P53708 422 2.57e-02 2 7 1 0.143 0.500 GO:0070435 CC 1 Shc-EGFR complex 1 P00533 422 2.57e-02 2 7 1 0.143 0.500 GO:0034678 CC 1 integrin alpha8-beta1 complex 1 P53708 422 2.57e-02 2 7 1 0.143 0.500 GO:0010764 BP 1 negative regulation of fibroblast migration 1 Q12891 422 2.57e-02 2 7 1 0.143 0.500 GO:0003097 BP 1 renal water transport 1 Q12891 422 2.57e-02 2 7 1 0.143 0.500 GO:0032430 BP 1 positive regulation of phospholipase A2 activity 1 P00533 422 2.57e-02 2 7 1 0.143 0.500 GO:0019087 BP 1 transformation of host cell by virus 1 Q12891 422 2.68e-02 427 7 2 0.286 0.005 MI:mmu-miR-697 mi 1 MI:mmu-miR-697 1 O43529,P54289 422 2.69e-02 428 7 2 0.286 0.005 MI:hsa-miR-936 mi 1 MI:hsa-miR-936 1 P00533,P54289 422 2.79e-02 93 7 2 0.286 0.022 GO:0009411 BP 1 response to UV 1 Q12891,P00533 422 2.79e-02 93 7 2 0.286 0.022 GO:0072001 BP 1 renal system development 1 Q12891,P53708 422 2.85e-02 94 7 2 0.286 0.021 GO:0042306 BP 1 regulation of protein import into nucleus 1 Q12891,P00533 422 2.93e-02 7 7 1 0.143 0.143 HP:0010497 hp 1 Sirenomelia 1 P53708 422 2.97e-02 96 7 2 0.286 0.021 GO:1904589 BP 1 regulation of protein import 1 Q12891,P00533 422 3.03e-02 97 7 2 0.286 0.021 GO:0050730 BP 1 regulation of peptidyl-tyrosine phosphorylation 1 Q12891,P00533 422 3.07e-02 459 7 2 0.286 0.004 MI:hsa-miR-33b mi 1 MI:hsa-miR-33b 1 P54289,Q6UWY0 422 3.22e-02 100 7 2 0.286 0.020 GO:0001655 BP 1 urogenital system development 1 Q12891,P53708 422 3.30e-02 477 7 2 0.286 0.004 MI:hsa-miR-498 mi 1 MI:hsa-miR-498 1 Q12891,P00533 422 3.36e-02 482 7 2 0.286 0.004 MI:hsa-miR-491-3p mi 1 MI:hsa-miR-491-3p 1 P00533,P54289 422 3.48e-02 491 7 2 0.286 0.004 MI:hsa-miR-525-3p mi 1 MI:hsa-miR-525-3p 1 Q12891,O43529 422 3.68e-02 506 7 2 0.286 0.004 MI:hsa-miR-524-3p mi 1 MI:hsa-miR-524-3p 1 Q12891,O43529 422 3.75e-02 3 7 1 0.143 0.333 CORUM:6036 cor 1 PARK2-EPS15-EGFR 1 P00533 422 3.75e-02 3 7 1 0.143 0.333 CORUM:3678 cor 1 RIN1-STAM2-EGFR complex, EGF stimulated 1 P00533 422 3.75e-02 3 7 1 0.143 0.333 CORUM:2454 cor 1 CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated 1 P00533 422 3.75e-02 3 7 1 0.143 0.333 CORUM:5171 cor 1 SH3KBP1-CBLB-EGFR complex 1 P00533 422 3.75e-02 3 7 1 0.143 0.333 CORUM:2369 cor 1 ITGAV-ITGB3-EGFR complex 1 P00533 422 3.75e-02 3 7 1 0.143 0.333 CORUM:2542 cor 1 EGFR-CBL-GRB2 complex 1 P00533 422 3.76e-02 9 7 1 0.143 0.111 HP:0012272 hp 1 J wave 1 P54289 422 3.85e-02 3 7 1 0.143 0.333 GO:0097487 CC 1 multivesicular body, internal vesicle 1 P00533 422 3.85e-02 3 7 1 0.143 0.333 GO:0004415 MF 1 hyalurononglucosaminidase activity 1 Q12891 422 4.18e-02 10 7 1 0.143 0.100 HP:0012232 hp 1 Shortened QT interval 1 P54289 422 4.18e-02 10 7 1 0.143 0.100 HP:0011705 hp 1 First degree atrioventricular block 1 P54289 422 4.18e-02 10 7 1 0.143 0.100 HP:0200034 hp 1 Papule 1 P00533 422 4.18e-02 10 7 1 0.143 0.100 HP:0001818 hp 1 Paronychia 1 P00533 422 4.54e-02 119 7 2 0.286 0.017 GO:1900180 BP 1 regulation of protein localization to nucleus 1 Q12891,P00533 422 4.56e-02 63 7 2 0.286 0.032 KEGG:05412 keg 1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1 P53708,P54289 422 4.59e-02 11 7 1 0.143 0.091 HP:0200039 hp 1 Pustule 1 P00533 422 4.77e-02 122 7 2 0.286 0.016 GO:0046822 BP 1 regulation of nucleocytoplasmic transport 1 Q12891,P00533 422 4.77e-02 483 7 3 0.429 0.006 GO:0051050 BP 1 positive regulation of transport 1 Q12891,P00533,P54289 422 4.84e-02 123 7 2 0.286 0.016 GO:0045121 CC 1 membrane raft 1 Q12891,P00533 422 4.92e-02 124 7 2 0.286 0.016 GO:0098857 CC 1 membrane microdomain 1 Q12891,P00533 422 5.00e-02 4 7 1 0.143 0.250 CORUM:1185 cor 1 EGFR-containing signaling complex 1 P00533 422 5.00e-02 13 7 1 0.143 0.077 OMIM:211980 omi 1 LUNG CANCERALVEOLAR CELL CARCINOMA, INCLUDED;;ADENOCARCINOMA OF LUNG, INCLUDED;;NONSMALL CELL LUNG CANCER, INCLUDED;;LUNG CANCER, PROTECTION AGAINST, INCLUDED 1 P00533 422 5.00e-02 1 7 1 0.143 1.000 REAC:5638302 rea 1 Signaling by Overexpressed Wild-Type EGFR in Cancer 1 P00533 422 5.00e-02 28 7 2 0.286 0.071 TF:M06553_0 tf 1 Factor: Apak; motif: NGGGAARTAGGA; match class: 0 1 P54289,Q6UWY0 422 5.00e-02 125 7 2 0.286 0.016 GO:0098797 CC 1 plasma membrane protein complex 1 P53708,P00533 422 5.00e-02 4 7 1 0.143 0.250 CORUM:1095 cor 1 SNX complex (SNX1a, SNX2, SNX4, EGFR) 1 P00533 422 5.00e-02 12 7 1 0.143 0.083 HP:0001805 hp 1 Thick nail 1 P00533 422 5.00e-02 12 7 1 0.143 0.083 HP:0002573 hp 1 Hematochezia 1 P00533 422 5.00e-02 12 7 1 0.143 0.083 HP:0100803 hp 1 Abnormality of the periungual region 1 P00533 422 5.00e-02 1 7 1 0.143 1.000 REAC:5638303 rea 1 Inhibition of Signaling by Overexpressed EGFR 1 P00533 422 5.00e-02 66 7 2 0.286 0.030 KEGG:05410 keg 1 Hypertrophic cardiomyopathy (HCM) 1 P53708,P54289 422 5.00e-02 4 7 1 0.143 0.250 CORUM:2453 cor 1 Multiprotein complex (monoubiquitination) 1 P00533 423 7.60e-04 1 2 1 0.500 1.000 GO:0003956 MF 1 NAD(P)+-protein-arginine ADP-ribosyltransferase activity 1 Q8N6T7 423 1.52e-03 2 2 1 0.500 0.500 GO:0032129 MF 1 histone deacetylase activity (H3-K9 specific) 1 Q8N6T7 423 1.52e-03 2 2 1 0.500 0.500 GO:0005724 CC 1 nuclear telomeric heterochromatin 1 Q8N6T7 423 1.52e-03 2 2 1 0.500 0.500 GO:0046969 MF 1 NAD-dependent histone deacetylase activity (H3-K9 specific) 1 Q8N6T7 423 1.52e-03 2 2 1 0.500 0.500 GO:0004360 MF 1 glutamine-fructose-6-phosphate transaminase (isomerizing) activity 1 O94808 423 1.65e-03 455 2 2 1.000 0.004 MI:hsa-miR-198 mi 1 MI:hsa-miR-198 1 Q8N6T7,O94808 423 2.28e-03 3 2 1 0.500 0.333 GO:0070548 MF 1 L-glutamine aminotransferase activity 1 O94808 423 3.04e-03 4 2 1 0.500 0.250 GO:0031933 CC 1 telomeric heterochromatin 1 Q8N6T7 423 3.04e-03 4 2 1 0.500 0.250 GO:0017136 MF 1 NAD-dependent histone deacetylase activity 1 Q8N6T7 423 3.66e-03 8 2 1 0.500 0.125 REAC:446210 rea 1 Synthesis of UDP-N-acetyl-glucosamine 1 O94808 423 3.80e-03 5 2 1 0.500 0.200 GO:0034979 MF 1 NAD-dependent protein deacetylase activity 1 Q8N6T7 423 4.56e-03 6 2 1 0.500 0.167 GO:0070403 MF 1 NAD+ binding 1 Q8N6T7 423 4.56e-03 6 2 1 0.500 0.167 GO:0006002 BP 1 fructose 6-phosphate metabolic process 1 O94808 423 7.14e-03 466 2 2 1.000 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q8N6T7,O94808 423 7.77e-03 9 2 1 0.500 0.111 TF:M03971_1 tf 1 Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1 1 Q8N6T7 423 8.35e-03 11 2 1 0.500 0.091 GO:0006048 BP 1 UDP-N-acetylglucosamine biosynthetic process 1 O94808 423 9.11e-03 12 2 1 0.500 0.083 GO:0006047 BP 1 UDP-N-acetylglucosamine metabolic process 1 O94808 423 9.11e-03 12 2 1 0.500 0.083 GO:0046349 BP 1 amino sugar biosynthetic process 1 O94808 423 1.14e-02 15 2 1 0.500 0.067 GO:0010569 BP 1 regulation of double-strand break repair via homologous recombination 1 Q8N6T7 423 1.14e-02 15 2 1 0.500 0.067 GO:0051287 MF 1 NAD binding 1 Q8N6T7 423 1.21e-02 16 2 1 0.500 0.062 GO:0003950 MF 1 NAD+ ADP-ribosyltransferase activity 1 Q8N6T7 423 1.29e-02 17 2 1 0.500 0.059 GO:0008483 MF 1 transaminase activity 1 O94808 423 1.35e-02 1256 2 2 1.000 0.002 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 Q8N6T7,O94808 423 1.37e-02 18 2 1 0.500 0.056 GO:0005720 CC 1 nuclear heterochromatin 1 Q8N6T7 423 1.38e-02 16 2 1 0.500 0.062 TF:M06258_0 tf 1 Factor: ZNF345; motif: KGGGGCAAACGC; match class: 0 1 O94808 423 1.44e-02 19 2 1 0.500 0.053 GO:0009226 BP 1 nucleotide-sugar biosynthetic process 1 O94808 423 1.44e-02 19 2 1 0.500 0.053 GO:0016769 MF 1 transferase activity, transferring nitrogenous groups 1 O94808 423 1.52e-02 20 2 1 0.500 0.050 GO:0006471 BP 1 protein ADP-ribosylation 1 Q8N6T7 423 1.81e-02 21 2 1 0.500 0.048 TF:M03971_0 tf 1 Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 0 1 Q8N6T7 423 1.90e-02 25 2 1 0.500 0.040 GO:0009225 BP 1 nucleotide-sugar metabolic process 1 O94808 423 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 Q8N6T7,O94808 423 2.09e-02 798 2 2 1.000 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q8N6T7,O94808 423 2.10e-02 114 2 1 0.500 0.009 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q8N6T7 423 2.28e-02 30 2 1 0.500 0.033 GO:0006040 BP 1 amino sugar metabolic process 1 O94808 423 2.35e-02 31 2 1 0.500 0.032 GO:2000779 BP 1 regulation of double-strand break repair 1 Q8N6T7 423 2.37e-02 52 2 1 0.500 0.019 REAC:446219 rea 1 Synthesis of substrates in N-glycan biosythesis 1 O94808 423 2.42e-02 28 2 1 0.500 0.036 TF:M06101_0 tf 1 Factor: ZNF17; motif: KGGWTYTGCCGC; match class: 0 1 O94808 423 2.50e-02 33 2 1 0.500 0.030 GO:0000018 BP 1 regulation of DNA recombination 1 Q8N6T7 423 2.68e-02 889 2 2 1.000 0.002 TF:M00051_1 tf 1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 1 Q8N6T7,O94808 423 2.81e-02 37 2 1 0.500 0.027 GO:0004407 MF 1 histone deacetylase activity 1 Q8N6T7 423 2.88e-02 38 2 1 0.500 0.026 GO:0033558 MF 1 protein deacetylase activity 1 Q8N6T7 423 2.93e-02 34 2 1 0.500 0.029 TF:M06704_0 tf 1 Factor: ZNF226; motif: NGGGTAATAASA; match class: 0 1 Q8N6T7 423 2.96e-02 39 2 1 0.500 0.026 GO:0000792 CC 1 heterochromatin 1 Q8N6T7 423 2.96e-02 65 2 1 0.500 0.015 REAC:446193 rea 1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 1 O94808 423 3.19e-02 42 2 1 0.500 0.024 GO:0016763 MF 1 transferase activity, transferring pentosyl groups 1 Q8N6T7 423 3.36e-02 39 2 1 0.500 0.026 TF:M02009_1 tf 1 Factor: GCNF; motif: NRAGGTCAAN; match class: 1 1 Q8N6T7 423 3.37e-02 74 2 1 0.500 0.014 REAC:5693607 rea 1 Processing of DNA double-strand break ends 1 Q8N6T7 423 3.41e-02 45 2 1 0.500 0.022 GO:0019213 MF 1 deacetylase activity 1 Q8N6T7 423 3.67e-02 200 2 1 0.500 0.005 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 Q8N6T7 423 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q8N6T7 423 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q8N6T7,O94808 423 3.79e-02 50 2 1 0.500 0.020 GO:0006112 BP 1 energy reserve metabolic process 1 O94808 423 3.98e-02 217 2 1 0.500 0.005 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 Q8N6T7 423 4.02e-02 2165 2 2 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q8N6T7,O94808 423 4.05e-02 221 2 1 0.500 0.005 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 Q8N6T7 423 4.07e-02 2177 2 2 1.000 0.001 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q8N6T7,O94808 423 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q8N6T7 423 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q8N6T7,O94808 423 4.70e-02 62 2 1 0.500 0.016 GO:0016811 MF 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1 Q8N6T7 423 4.71e-02 2342 2 2 1.000 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q8N6T7,O94808 423 4.73e-02 104 2 1 0.500 0.010 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 Q8N6T7 423 4.85e-02 265 2 1 0.500 0.004 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 Q8N6T7 423 5.00e-02 29 2 1 0.500 0.034 KEGG:00250 keg 1 Alanine, aspartate and glutamate metabolism 1 O94808 423 5.00e-02 110 2 1 0.500 0.009 REAC:5693538 rea 1 Homology Directed Repair 1 Q8N6T7 423 5.00e-02 66 2 1 0.500 0.015 GO:0006282 BP 1 regulation of DNA repair 1 Q8N6T7 423 5.00e-02 58 2 1 0.500 0.017 TF:M07085_1 tf 1 Factor: E2F-6; motif: RGGCGGGARRN; match class: 1 1 Q8N6T7 424 3.17e-02 342 1 1 1.000 0.003 HPA:039020_03 hpa 1 soft tissue 1; chondrocytes[Uncertain,High] 1 P49184 424 3.40e-02 284 1 1 1.000 0.004 MI:hsa-miR-625* mi 1 MI:hsa-miR-625* 1 P49184 424 4.23e-02 354 1 1 1.000 0.003 MI:hsa-miR-93* mi 1 MI:hsa-miR-93* 1 P49184 424 4.38e-02 366 1 1 1.000 0.003 MI:hsa-miR-138-2* mi 1 MI:hsa-miR-138-2* 1 P49184 424 4.53e-02 379 1 1 1.000 0.003 MI:mmu-miR-343 mi 1 MI:mmu-miR-343 1 P49184 424 4.55e-02 380 1 1 1.000 0.003 MI:hsa-miR-29b-2* mi 1 MI:hsa-miR-29b-2* 1 P49184 424 4.88e-02 408 1 1 1.000 0.002 MI:hsa-miR-331-3p mi 1 MI:hsa-miR-331-3p 1 P49184 424 4.93e-02 412 1 1 1.000 0.002 MI:hsa-miR-216a mi 1 MI:hsa-miR-216a 1 P49184 424 4.98e-02 416 1 1 1.000 0.002 MI:hsa-miR-644 mi 1 MI:hsa-miR-644 1 P49184 424 5.00e-02 2 1 1 1.000 0.500 TF:M00639_1 tf 1 Factor: HNF-6; motif: HWAAATCAATAW; match class: 1 1 P49184 424 5.00e-02 2 1 1 1.000 0.500 TF:M03957_1 tf 1 Factor: ONECUT3; motif: NAAAAATCRATAAN; match class: 1 1 P49184 424 5.00e-02 56 1 1 1.000 0.018 GO:0004536 MF 1 deoxyribonuclease activity 1 P49184 424 5.00e-02 418 1 1 1.000 0.002 MI:gga-miR-460 mi 1 MI:gga-miR-460 1 P49184 424 5.00e-02 2 1 1 1.000 0.500 TF:M03956_1 tf 1 Factor: ONECUT2; motif: NAAAAATCRATANN; match class: 1 1 P49184 425 1.35e-14 5 4 4 1.000 0.800 GO:0008622 CC 1 epsilon DNA polymerase complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.70e-12 14 4 4 1.000 0.286 GO:0000109 CC 1 nucleotide-excision repair complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.70e-12 14 4 4 1.000 0.286 GO:0042575 CC 1 DNA polymerase complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.04e-11 19 4 4 1.000 0.211 GO:0003887 MF 1 DNA-directed DNA polymerase activity 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.03e-11 26 4 4 1.000 0.154 GO:0034061 MF 1 DNA polymerase activity 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.03e-11 26 4 4 1.000 0.154 GO:0043601 CC 1 nuclear replisome 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.73e-11 27 4 4 1.000 0.148 GO:0030894 CC 1 replisome 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.78e-10 37 4 4 1.000 0.108 GO:1990391 CC 1 DNA repair complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.46e-10 40 4 4 1.000 0.100 GO:0043596 CC 1 nuclear replication fork 1 P56282,Q9NR33,Q9NRF9,Q07864 425 9.49e-10 8 4 4 1.000 0.500 REAC:174430 rea 1 Telomere C-strand synthesis initiation 1 P56282,Q9NR33,Q9NRF9,Q07864 425 9.49e-10 8 4 4 1.000 0.500 REAC:68952 rea 1 DNA replication initiation 1 P56282,Q9NR33,Q9NRF9,Q07864 425 9.89e-10 56 4 4 1.000 0.071 GO:0005657 CC 1 replication fork 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.62e-09 15 4 4 1.000 0.267 CORUM:1108 cor 1 DNA synthesome complex (15 subunits) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.93e-09 73 4 4 1.000 0.055 GO:0032993 CC 1 protein-DNA complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.86e-09 18 4 4 1.000 0.222 CORUM:1111 cor 1 DNA synthesome complex (17 subunits) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.86e-09 18 4 4 1.000 0.222 CORUM:1099 cor 1 DNA synthesome complex (17 subunits) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.29e-08 105 4 4 1.000 0.038 GO:0016779 MF 1 nucleotidyltransferase activity 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.15e-08 31 4 4 1.000 0.129 KEGG:03410 keg 1 Base excision repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.89e-08 36 4 4 1.000 0.111 KEGG:03030 keg 1 DNA replication 1 P56282,Q9NR33,Q9NRF9,Q07864 425 8.11e-08 21 4 4 1.000 0.190 REAC:5651801 rea 1 PCNA-Dependent Long Patch Base Excision Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.44e-07 24 4 4 1.000 0.167 REAC:110373 rea 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.44e-07 24 4 4 1.000 0.167 REAC:174417 rea 1 Telomere C-strand (Lagging Strand) Synthesis 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.44e-07 24 4 4 1.000 0.167 REAC:5696397 rea 1 Gap-filling DNA repair synthesis and ligation in GG-NER 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.49e-07 45 4 4 1.000 0.089 KEGG:03420 keg 1 Nucleotide excision repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.38e-07 216 4 4 1.000 0.019 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.77e-07 28 4 4 1.000 0.143 REAC:110314 rea 1 Recognition of DNA damage by PCNA-containing replication complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.22e-07 29 4 4 1.000 0.138 REAC:5656169 rea 1 Termination of translesion DNA synthesis 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.71e-07 30 4 4 1.000 0.133 REAC:180786 rea 1 Extension of Telomeres 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.26e-07 31 4 4 1.000 0.129 REAC:68962 rea 1 Activation of the pre-replicative complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.10e-07 35 4 4 1.000 0.114 REAC:73933 rea 1 Resolution of Abasic Sites (AP sites) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.10e-07 35 4 4 1.000 0.114 REAC:73884 rea 1 Base Excision Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.98e-07 36 4 4 1.000 0.111 REAC:110313 rea 1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.24e-06 40 4 4 1.000 0.100 REAC:5696400 rea 1 Dual Incision in GG-NER 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.79e-06 357 4 4 1.000 0.011 GO:0044454 CC 1 nuclear chromosome part 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.84e-06 44 4 4 1.000 0.091 REAC:73893 rea 1 DNA Damage Bypass 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.38e-06 383 4 4 1.000 0.010 GO:0000228 CC 1 nuclear chromosome 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.19e-06 95 4 4 1.000 0.042 KEGG:00240 keg 1 Pyrimidine metabolism 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.39e-06 51 4 4 1.000 0.078 REAC:157579 rea 1 Telomere Maintenance 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.07e-06 61 4 4 1.000 0.066 REAC:5685942 rea 1 HDR through Homologous Recombination (HRR) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 8.07e-06 63 4 4 1.000 0.063 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 P56282,Q9NR33,Q9NRF9,Q07864 425 8.61e-06 64 4 4 1.000 0.062 REAC:6782135 rea 1 Dual incision in TC-NER 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.13e-05 565 4 4 1.000 0.007 GO:0044427 CC 1 chromosomal part 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.53e-05 609 4 4 1.000 0.007 GO:0005694 CC 1 chromosome 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.63e-05 14 4 2 0.500 0.143 GO:0005671 CC 1 Ada2/Gcn5/Ada3 transcription activator complex 1 Q9NR33,Q9NRF9 425 1.68e-05 624 4 4 1.000 0.006 GO:1990234 CC 1 transferase complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.83e-05 77 4 4 1.000 0.052 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.93e-05 78 4 4 1.000 0.051 REAC:73886 rea 1 Chromosome Maintenance 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.08e-05 151 4 4 1.000 0.026 KEGG:00230 keg 1 Purine metabolism 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.49e-05 83 4 4 1.000 0.048 REAC:68874 rea 1 M/G1 Transition 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.49e-05 83 4 4 1.000 0.048 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.49e-05 83 4 4 1.000 0.048 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.62e-05 755 4 4 1.000 0.005 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.10e-05 99 4 4 1.000 0.040 REAC:69239 rea 1 Synthesis of DNA 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.14e-05 217 4 3 0.750 0.014 GO:0006260 BP 1 DNA replication 1 P56282,Q9NRF9,Q07864 425 6.23e-05 104 4 4 1.000 0.038 REAC:5693567 rea 1 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 1 P56282,Q9NR33,Q9NRF9,Q07864 425 6.73e-05 106 4 4 1.000 0.038 REAC:69306 rea 1 DNA Replication 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.54e-05 109 4 4 1.000 0.037 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 7.76e-05 30 4 2 0.500 0.067 GO:0006270 BP 1 DNA replication initiation 1 P56282,Q07864 425 7.82e-05 110 4 4 1.000 0.036 REAC:5693538 rea 1 Homology Directed Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 8.30e-05 31 4 2 0.500 0.065 GO:0000722 BP 1 telomere maintenance via recombination 1 P56282,Q07864 425 9.16e-05 218 4 4 1.000 0.018 KEGG:05166 keg 1 HTLV-I infection 1 P56282,Q9NR33,Q9NRF9,Q07864 425 9.37e-05 115 4 4 1.000 0.035 REAC:69206 rea 1 G1/S Transition 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.25e-04 38 4 2 0.500 0.053 GO:1902562 CC 1 H4 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 425 1.27e-04 1033 4 4 1.000 0.004 GO:1902494 CC 1 catalytic complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.36e-04 126 4 4 1.000 0.032 REAC:69242 rea 1 S Phase 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.61e-04 43 4 2 0.500 0.047 GO:0006312 BP 1 mitotic recombination 1 P56282,Q07864 425 1.90e-04 137 4 4 1.000 0.029 REAC:5693532 rea 1 DNA Double-Strand Break Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.96e-04 138 4 4 1.000 0.029 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.27e-04 51 4 2 0.500 0.039 GO:0043966 BP 1 histone H3 acetylation 1 Q9NR33,Q9NRF9 425 3.93e-04 67 4 2 0.500 0.030 GO:0000731 BP 1 DNA synthesis involved in DNA repair 1 P56282,Q07864 425 5.75e-04 81 4 2 0.500 0.025 GO:0000123 CC 1 histone acetyltransferase complex 1 Q9NR33,Q9NRF9 425 7.26e-04 91 4 2 0.500 0.022 GO:0031248 CC 1 protein acetyltransferase complex 1 Q9NR33,Q9NRF9 425 7.26e-04 91 4 2 0.500 0.022 GO:1902493 CC 1 acetyltransferase complex 1 Q9NR33,Q9NRF9 425 9.30e-04 103 4 2 0.500 0.019 GO:0016573 BP 1 histone acetylation 1 Q9NR33,Q9NRF9 425 9.66e-04 105 4 2 0.500 0.019 GO:0018393 BP 1 internal peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 425 9.67e-04 1715 4 4 1.000 0.002 GO:0016740 MF 1 transferase activity 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.00e-03 107 4 2 0.500 0.019 GO:0018394 BP 1 peptidyl-lysine acetylation 1 Q9NR33,Q9NRF9 425 1.04e-03 109 4 2 0.500 0.018 GO:0000723 BP 1 telomere maintenance 1 P56282,Q07864 425 1.06e-03 110 4 2 0.500 0.018 GO:0032200 BP 1 telomere organization 1 P56282,Q07864 425 1.06e-03 110 4 2 0.500 0.018 GO:0006475 BP 1 internal protein amino acid acetylation 1 Q9NR33,Q9NRF9 425 1.24e-03 119 4 2 0.500 0.017 GO:0006261 BP 1 DNA-dependent DNA replication 1 P56282,Q07864 425 1.41e-03 127 4 2 0.500 0.016 GO:0006473 BP 1 protein acetylation 1 Q9NR33,Q9NRF9 425 1.48e-03 670 4 3 0.750 0.004 GO:0006259 BP 1 DNA metabolic process 1 P56282,Q9NRF9,Q07864 425 1.65e-03 1960 4 4 1.000 0.002 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.65e-03 1960 4 4 1.000 0.002 GO:0043228 CC 1 non-membrane-bounded organelle 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.71e-03 140 4 2 0.500 0.014 GO:0071897 BP 1 DNA biosynthetic process 1 P56282,Q07864 425 1.75e-03 1 4 1 0.250 1.000 OMIM:615139 omi 1 FACIAL DYSMORPHISM, IMMUNODEFICIENCY, LIVEDO, AND SHORT STATURE; FILS 1 Q07864 425 1.75e-03 1 4 1 0.250 1.000 OMIM:615083 omi 1 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12; CRCS12;;COLORECTAL CANCER, SUSCEPTIBILITY TO, ON CHROMOSOME 12q24 1 Q07864 425 1.92e-03 148 4 2 0.500 0.014 GO:0043543 BP 1 protein acylation 1 Q9NR33,Q9NRF9 425 2.06e-03 3 4 1 0.250 0.333 GO:0006287 BP 1 base-excision repair, gap-filling 1 Q07864 425 2.16e-03 2096 4 4 1.000 0.002 GO:0043234 CC 1 protein complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.24e-03 160 4 2 0.500 0.013 GO:0006310 BP 1 DNA recombination 1 P56282,Q07864 425 2.76e-03 178 4 2 0.500 0.011 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P56282,Q07864 425 2.98e-03 185 4 2 0.500 0.011 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P56282,Q07864 425 3.02e-03 272 4 4 1.000 0.015 REAC:73894 rea 1 DNA Repair 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.45e-03 199 4 2 0.500 0.010 GO:0060249 BP 1 anatomical structure homeostasis 1 P56282,Q07864 425 3.54e-03 315 4 2 0.500 0.006 TF:M00740_1 tf 1 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC; match class: 1 1 P56282,Q07864 425 3.70e-03 322 4 2 0.500 0.006 TF:M04129_0 tf 1 Factor: TBX20; motif: WAGGTGTGAAR; match class: 0 1 Q9NR33,Q9NRF9 425 4.17e-03 342 4 2 0.500 0.006 TF:M04131_0 tf 1 Factor: TBX21; motif: AAGGTGTGAA; match class: 0 1 Q9NR33,Q9NRF9 425 4.39e-03 14 4 1 0.250 0.071 TF:M06771_0 tf 1 Factor: ZNF228; motif: NGGACTGTGTCC; match class: 0 1 Q07864 425 4.39e-03 14 4 1 0.250 0.071 TF:M01043_1 tf 1 Factor: Nkx2-5; motif: TSYCACTTSM; match class: 1 1 Q9NRF9 425 4.58e-03 2529 4 4 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 P56282,Q9NR33,Q9NRF9,Q07864 425 6.82e-03 281 4 2 0.500 0.007 GO:0016570 BP 1 histone modification 1 Q9NR33,Q9NRF9 425 7.26e-03 290 4 2 0.500 0.007 GO:0016569 BP 1 covalent chromatin modification 1 Q9NR33,Q9NRF9 425 7.36e-03 457 4 2 0.500 0.004 TF:M04240_1 tf 1 Factor: FOXD3; motif: NRNWAATATTKACN; match class: 1 1 Q9NR33,Q9NRF9 425 7.56e-03 296 4 2 0.500 0.007 GO:0018205 BP 1 peptidyl-lysine modification 1 Q9NR33,Q9NRF9 425 7.83e-03 25 4 1 0.250 0.040 TF:M05808_0 tf 1 Factor: ZNF574; motif: NAGTCGTWAAWC; match class: 0 1 Q9NR33 425 8.26e-03 2931 4 4 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.04e-02 4064 4 4 1.000 0.001 TF:M01814_0 tf 1 Factor: AML2; motif: CCRCACCA; match class: 0 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.07e-02 554 4 2 0.500 0.004 TF:M04323_0 tf 1 Factor: GBX2; motif: TAATTGNNCAATTA; match class: 0 1 P56282,Q9NRF9 425 1.13e-02 3168 4 4 1.000 0.001 GO:0044428 CC 1 nuclear part 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.24e-02 18 4 1 0.250 0.056 GO:0042276 BP 1 error-prone translesion synthesis 1 P56282 425 1.26e-02 384 4 2 0.500 0.005 GO:0006281 BP 1 DNA repair 1 P56282,Q07864 425 1.44e-02 411 4 2 0.500 0.005 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P56282,Q07864 425 1.52e-02 3415 4 4 1.000 0.001 GO:0032991 CC 1 macromolecular complex 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.54e-02 425 4 2 0.500 0.005 GO:0044770 BP 1 cell cycle phase transition 1 P56282,Q07864 425 1.55e-02 4 4 1 0.250 0.250 CORUM:234 cor 1 HuCHRAC complex 1 Q9NRF9 425 1.58e-02 23 4 1 0.250 0.043 GO:0006297 BP 1 nucleotide-excision repair, DNA gap filling 1 Q07864 425 1.69e-02 446 4 2 0.500 0.004 GO:0051276 BP 1 chromosome organization 1 P56282,Q07864 425 1.71e-02 449 4 2 0.500 0.004 GO:0006325 BP 1 chromatin organization 1 Q9NR33,Q9NRF9 425 1.77e-02 2189 4 3 0.750 0.001 TF:M00322_0 tf 1 Factor: c-Myc:Max; motif: GCCAYGYGSN; match class: 0 1 P56282,Q9NR33,Q9NRF9 425 1.80e-02 3561 4 4 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.80e-02 3561 4 4 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.80e-02 3561 4 4 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 P56282,Q9NR33,Q9NRF9,Q07864 425 1.84e-02 59 4 1 0.250 0.017 TF:M01728_1 tf 1 Factor: EAR2; motif: YGNNCTTTGNCCTK; match class: 1 1 Q9NRF9 425 1.87e-02 60 4 1 0.250 0.017 TF:M06446_0 tf 1 Factor: ZNF525; motif: NSTTAAAYCAGA; match class: 0 1 P56282 425 2.03e-02 65 4 1 0.250 0.015 TF:M06433_0 tf 1 Factor: ZNF571; motif: NTGTCAASATSM; match class: 0 1 Q07864 425 2.09e-02 67 4 1 0.250 0.015 TF:M06141_0 tf 1 Factor: ZNF708; motif: NGKGGAAAAGGW; match class: 0 1 Q9NRF9 425 2.19e-02 32 4 1 0.250 0.031 GO:0006284 BP 1 base-excision repair 1 Q07864 425 2.24e-02 448 4 4 1.000 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.28e-02 521 4 2 0.500 0.004 GO:0044451 CC 1 nucleoplasm part 1 Q9NR33,Q9NRF9 425 2.48e-02 5054 4 4 1.000 0.001 TF:M01659_0 tf 1 Factor: Cdx-2; motif: BNNATAAANRN; match class: 0 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.54e-02 867 4 2 0.500 0.002 TF:M01834_0 tf 1 Factor: Hoxd9; motif: AVNCATWAAA; match class: 0 1 P56282,Q9NR33 425 2.54e-02 37 4 1 0.250 0.027 GO:0019985 BP 1 translesion synthesis 1 P56282 425 2.54e-02 3882 4 4 1.000 0.001 GO:0016043 BP 1 cellular component organization 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.55e-02 870 4 2 0.500 0.002 TF:M06686_0 tf 1 Factor: PRDM9; motif: TTTGTGGAGA; match class: 0 1 Q9NR33,Q9NRF9 425 2.74e-02 88 4 1 0.250 0.011 TF:M04120_0 tf 1 Factor: TBR1; motif: AAGGTGTGAAA; match class: 0 1 Q9NR33 425 2.89e-02 93 4 1 0.250 0.011 TF:M01235_0 tf 1 Factor: ipf1; motif: NVSTAATTAC; match class: 0 1 Q9NRF9 425 2.91e-02 4013 4 4 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.92e-02 4019 4 4 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 P56282,Q9NR33,Q9NRF9,Q07864 425 2.92e-02 592 4 2 0.500 0.003 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P56282,Q07864 425 2.95e-02 95 4 1 0.250 0.011 TF:M04356_0 tf 1 Factor: HOXC12; motif: RGTCGTAAAAN; match class: 0 1 Q9NR33 425 2.97e-02 5285 4 4 1.000 0.001 TF:M02052_1 tf 1 Factor: EHF; motif: CSCGGAARTN; match class: 1 1 P56282,Q9NR33,Q9NRF9,Q07864 425 3.11e-02 100 4 1 0.250 0.010 TF:M05668_0 tf 1 Factor: ZNF154; motif: NGTGAAATCAGA; match class: 0 1 P56282 425 3.17e-02 102 4 1 0.250 0.010 TF:M04172_0 tf 1 Factor: HEY1; motif: GRCACGTGCC; match class: 0 1 Q9NR33 425 3.17e-02 102 4 1 0.250 0.010 TF:M04173_0 tf 1 Factor: HEY2; motif: GNCACGTGYN; match class: 0 1 Q9NR33 425 3.28e-02 48 4 1 0.250 0.021 GO:0006301 BP 1 postreplication repair 1 P56282 425 3.29e-02 106 4 1 0.250 0.009 TF:M06254_0 tf 1 Factor: znf267; motif: NGCWACTGGCGC; match class: 0 1 Q07864 425 3.35e-02 108 4 1 0.250 0.009 TF:M07049_1 tf 1 Factor: MECP-2; motif: RSTTAYARAGCW; match class: 1 1 Q9NR33 425 3.50e-02 113 4 1 0.250 0.009 TF:M04022_0 tf 1 Factor: MEF-2A; motif: KCTAWAAATAGM; match class: 0 1 P56282 425 3.57e-02 657 4 2 0.500 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 P56282,Q07864 425 4.00e-02 2922 4 3 0.750 0.001 TF:M00974_1 tf 1 Factor: SMAD; motif: TNGNCAGACWN; match class: 1 1 P56282,Q9NR33,Q07864 425 4.08e-02 2941 4 3 0.750 0.001 TF:M00737_0 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 0 1 P56282,Q9NR33,Q07864 425 4.17e-02 1128 4 2 0.500 0.002 TF:M04115_0 tf 1 Factor: EOMES; motif: NAGGTGTGAANNN; match class: 0 1 Q9NR33,Q9NRF9 425 4.24e-02 137 4 1 0.250 0.007 TF:M04339_1 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 1 1 Q9NR33 425 4.24e-02 137 4 1 0.250 0.007 TF:M04352_1 tf 1 Factor: HOXC10; motif: GTCRTAAAAN; match class: 1 1 Q9NR33 425 4.26e-02 720 4 2 0.500 0.003 GO:0018193 BP 1 peptidyl-amino acid modification 1 Q9NR33,Q9NRF9 425 4.27e-02 721 4 2 0.500 0.003 GO:0000278 BP 1 mitotic cell cycle 1 P56282,Q07864 425 4.30e-02 139 4 1 0.250 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 P56282 425 4.32e-02 4430 4 4 1.000 0.001 GO:0005634 CC 1 nucleus 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.37e-02 5821 4 4 1.000 0.001 TF:M05548_0 tf 1 Factor: PLAGL2; motif: AAGGACC; match class: 0 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.39e-02 142 4 1 0.250 0.007 TF:M00938_1 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 1 P56282 425 4.42e-02 143 4 1 0.250 0.007 TF:M06082_0 tf 1 Factor: ZNF716; motif: NCAGGCAGCGGA; match class: 0 1 P56282 425 4.51e-02 1176 4 2 0.500 0.002 TF:M01261_0 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 0 1 P56282,Q9NRF9 425 4.60e-02 5895 4 4 1.000 0.001 TF:M04354_0 tf 1 Factor: HOXC11; motif: NGYMATAAAAN; match class: 0 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.60e-02 5896 4 4 1.000 0.001 TF:M00626_0 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 0 1 P56282,Q9NR33,Q9NRF9,Q07864 425 4.81e-02 156 4 1 0.250 0.006 TF:M04515_0 tf 1 Factor: E2F1; motif: WWTGGCGCCAAA; match class: 0 1 P56282 425 4.96e-02 3155 4 3 0.750 0.001 TF:M01253_0 tf 1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 0 1 Q9NR33,Q9NRF9,Q07864 425 5.00e-02 1 4 1 0.250 1.000 HP:0007421 hp 1 Telangiectases of the cheeks 1 Q07864 425 5.00e-02 29 4 1 0.250 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 Q07864 425 5.00e-02 547 4 4 1.000 0.007 REAC:1640170 rea 1 Cell Cycle 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.00e-02 1048 4 4 1.000 0.004 KEGG:01100 keg 1 Metabolic pathways 1 P56282,Q9NR33,Q9NRF9,Q07864 425 5.00e-02 470 4 3 0.750 0.006 MI:hsa-let-7c* mi 1 MI:hsa-let-7c* 1 P56282,Q9NR33,Q9NRF9 425 5.00e-02 783 4 2 0.500 0.003 GO:0042592 BP 1 homeostatic process 1 P56282,Q07864 425 5.00e-02 13 4 1 0.250 0.077 CORUM:1004 cor 1 RC complex during S-phase of cell cycle 1 Q07864 425 5.00e-02 13 4 1 0.250 0.077 CORUM:1005 cor 1 RC complex during G2/M-phase of cell cycle 1 Q07864 426 3.28e-06 4 5 2 0.400 0.500 GO:1902857 BP 1 positive regulation of non-motile cilium assembly 1 Q16181,Q9UHD8 426 3.28e-06 4 5 2 0.400 0.500 GO:0032156 CC 1 septin cytoskeleton 1 Q16181,Q9UHD8 426 3.28e-06 4 5 2 0.400 0.500 GO:0031105 CC 1 septin complex 1 Q16181,Q9UHD8 426 5.47e-06 5 5 2 0.400 0.400 GO:1902855 BP 1 regulation of non-motile cilium assembly 1 Q16181,Q9UHD8 426 2.87e-05 108 5 3 0.600 0.028 GO:0060491 BP 1 regulation of cell projection assembly 1 Q16181,Q9H3Q1,Q9UHD8 426 4.26e-05 13 5 2 0.400 0.154 GO:0045724 BP 1 positive regulation of cilium assembly 1 Q16181,Q9UHD8 426 7.39e-05 148 5 3 0.600 0.020 GO:0031346 BP 1 positive regulation of cell projection organization 1 Q16181,Q9H3Q1,Q9UHD8 426 1.14e-04 21 5 2 0.400 0.095 GO:1905515 BP 1 non-motile cilium assembly 1 Q16181,Q9UHD8 426 2.53e-04 31 5 2 0.400 0.065 GO:0001725 CC 1 stress fiber 1 Q16181,Q9UHD8 426 2.53e-04 31 5 2 0.400 0.065 GO:0097517 CC 1 contractile actin filament bundle 1 Q16181,Q9UHD8 426 2.87e-04 33 5 2 0.400 0.061 GO:0051291 BP 1 protein heterooligomerization 1 Q16181,Q9UHD8 426 3.05e-04 34 5 2 0.400 0.059 GO:0032432 CC 1 actin filament bundle 1 Q16181,Q9UHD8 426 3.06e-04 238 5 3 0.600 0.013 GO:0030031 BP 1 cell projection assembly 1 Q16181,Q9H3Q1,Q9UHD8 426 3.62e-04 37 5 2 0.400 0.054 GO:0042641 CC 1 actomyosin 1 Q16181,Q9UHD8 426 3.82e-04 38 5 2 0.400 0.053 GO:1902117 BP 1 positive regulation of organelle assembly 1 Q16181,Q9UHD8 426 4.17e-04 264 5 3 0.600 0.011 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 Q16181,Q9H3Q1,Q9UHD8 426 4.45e-04 41 5 2 0.400 0.049 GO:0097730 CC 1 non-motile cilium 1 Q16181,Q9UHD8 426 6.12e-04 48 5 2 0.400 0.042 GO:1902017 BP 1 regulation of cilium assembly 1 Q16181,Q9UHD8 426 6.34e-04 304 5 3 0.600 0.010 GO:0031344 BP 1 regulation of cell projection organization 1 Q16181,Q9H3Q1,Q9UHD8 426 6.47e-04 306 5 3 0.600 0.010 GO:0015629 CC 1 actin cytoskeleton 1 Q16181,Q9H3Q1,Q9UHD8 426 9.91e-04 61 5 2 0.400 0.033 GO:0097014 CC 1 ciliary plasm 1 Q16181,Q9UHD8 426 9.91e-04 61 5 2 0.400 0.033 GO:0005930 CC 1 axoneme 1 Q16181,Q9UHD8 426 1.05e-03 360 5 3 0.600 0.008 GO:0010638 BP 1 positive regulation of organelle organization 1 Q16181,Q9H3Q1,Q9UHD8 426 1.31e-03 70 5 2 0.400 0.029 GO:0044448 CC 1 cell cortex part 1 Q16181,Q9UHD8 426 1.65e-03 420 5 3 0.600 0.007 GO:0005911 CC 1 cell-cell junction 1 Q16181,Q9H3Q1,Q9UHD8 426 1.92e-03 85 5 2 0.400 0.024 GO:0008360 BP 1 regulation of cell shape 1 Q16181,Q9H3Q1 426 2.82e-03 504 5 3 0.600 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 Q16181,Q9H3Q1,Q9UHD8 426 3.52e-03 115 5 2 0.400 0.017 GO:0005938 CC 1 cell cortex 1 Q16181,Q9UHD8 426 3.95e-03 122 5 2 0.400 0.016 GO:0099568 CC 1 cytoplasmic region 1 Q16181,Q9UHD8 426 4.49e-03 130 5 2 0.400 0.015 GO:1902115 BP 1 regulation of organelle assembly 1 Q16181,Q9UHD8 426 4.73e-03 3 5 1 0.200 0.333 GO:0016476 BP 1 regulation of embryonic cell shape 1 Q16181 426 5.34e-03 142 5 2 0.400 0.014 GO:0044782 BP 1 cilium organization 1 Q16181,Q9UHD8 426 5.95e-03 650 5 3 0.600 0.005 GO:0030030 BP 1 cell projection organization 1 Q16181,Q9H3Q1,Q9UHD8 426 7.60e-03 707 5 3 0.600 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 Q16181,Q9H3Q1,Q9UHD8 426 7.60e-03 707 5 3 0.600 0.004 GO:0033043 BP 1 regulation of organelle organization 1 Q16181,Q9H3Q1,Q9UHD8 426 8.88e-03 746 5 3 0.600 0.004 GO:0030054 CC 1 cell junction 1 Q16181,Q9H3Q1,Q9UHD8 426 9.45e-03 6 5 1 0.200 0.167 GO:0031272 BP 1 regulation of pseudopodium assembly 1 Q9H3Q1 426 9.45e-03 6 5 1 0.200 0.167 GO:0031269 BP 1 pseudopodium assembly 1 Q9H3Q1 426 9.45e-03 6 5 1 0.200 0.167 GO:0031274 BP 1 positive regulation of pseudopodium assembly 1 Q9H3Q1 426 9.70e-03 769 5 3 0.600 0.004 GO:0015630 CC 1 microtubule cytoskeleton 1 Q16181,Q9H3Q1,Q9UHD8 426 1.10e-02 7 5 1 0.200 0.143 GO:0031268 BP 1 pseudopodium organization 1 Q9H3Q1 426 1.11e-02 206 5 2 0.400 0.010 GO:0060271 BP 1 cilium assembly 1 Q16181,Q9UHD8 426 1.25e-02 218 5 2 0.400 0.009 GO:0051259 BP 1 protein oligomerization 1 Q16181,Q9UHD8 426 1.26e-02 842 5 3 0.600 0.004 GO:0070271 BP 1 protein complex biogenesis 1 Q16181,Q9H3Q1,Q9UHD8 426 1.26e-02 842 5 3 0.600 0.004 GO:0006461 BP 1 protein complex assembly 1 Q16181,Q9H3Q1,Q9UHD8 426 1.27e-02 220 5 2 0.400 0.009 GO:0044441 CC 1 ciliary part 1 Q16181,Q9UHD8 426 1.49e-02 451 5 2 0.400 0.004 MI:hsa-miR-502-3p mi 1 MI:hsa-miR-502-3p 1 Q92599,Q9UHD8 426 1.53e-02 457 5 2 0.400 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 Q16181,Q9P0V9 426 1.66e-02 252 5 2 0.400 0.008 GO:0022604 BP 1 regulation of cell morphogenesis 1 Q16181,Q9H3Q1 426 1.73e-02 11 5 1 0.200 0.091 GO:0017049 MF 1 GTP-Rho binding 1 Q9H3Q1 426 1.80e-02 2805 5 4 0.800 0.001 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 Q16181,Q9H3Q1,Q9UHD8,Q9P0V9 426 1.85e-02 267 5 2 0.400 0.007 GO:0005929 CC 1 cilium 1 Q16181,Q9UHD8 426 1.91e-02 271 5 2 0.400 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q16181,Q9UHD8 426 1.92e-02 1440 5 3 0.600 0.002 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9H3Q1,Q9UHD8,Q9P0V9 426 1.96e-02 275 5 2 0.400 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q16181,Q9UHD8 426 1.99e-02 277 5 2 0.400 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q16181,Q9UHD8 426 2.06e-02 282 5 2 0.400 0.007 GO:0045296 MF 1 cadherin binding 1 Q16181,Q9UHD8 426 2.16e-02 1015 5 3 0.600 0.003 GO:0071822 BP 1 protein complex subunit organization 1 Q16181,Q9H3Q1,Q9UHD8 426 2.24e-02 294 5 2 0.400 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 Q16181,Q9UHD8 426 2.24e-02 2974 5 4 0.800 0.001 HPA:040030_02 hpa 1 soft tissue 2; fibroblasts[Uncertain,Medium] 1 Q16181,Q9H3Q1,Q9UHD8,Q9P0V9 426 2.57e-02 1599 5 3 0.600 0.002 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 Q9H3Q1,Q9UHD8,Q9P0V9 426 2.81e-02 1113 5 3 0.600 0.003 GO:0065003 BP 1 macromolecular complex assembly 1 Q16181,Q9H3Q1,Q9UHD8 426 2.82e-02 3268 5 5 1.000 0.002 TF:M07344_1 tf 1 Factor: ZIC1; motif: VGGGGAGS; match class: 1 1 Q16181,Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 2.96e-02 3206 5 4 0.800 0.001 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 Q16181,Q9H3Q1,Q9UHD8,Q9P0V9 426 3.20e-02 5424 5 5 1.000 0.001 HPA:030010_02 hpa 1 prostate; glandular cells[Uncertain,Medium] 1 Q16181,Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 3.22e-02 1168 5 3 0.600 0.003 GO:1902589 BP 1 single-organism organelle organization 1 Q16181,Q9H3Q1,Q9UHD8 426 3.27e-02 3292 5 4 0.800 0.001 HPA:016010_03 hpa 1 gallbladder; glandular cells[Uncertain,High] 1 Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 3.48e-02 369 5 2 0.400 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 Q16181,Q9UHD8 426 3.51e-02 1204 5 3 0.600 0.002 GO:0005856 CC 1 cytoskeleton 1 Q16181,Q9H3Q1,Q9UHD8 426 3.57e-02 1804 5 3 0.600 0.002 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q9H3Q1,Q9UHD8,Q9P0V9 426 3.71e-02 1830 5 3 0.600 0.002 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 Q9H3Q1,Q9UHD8,Q9P0V9 426 3.79e-02 5612 5 5 1.000 0.001 HPA:023010_01 hpa 1 lymph node; germinal center cells[Uncertain,Low] 1 Q16181,Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 4.01e-02 3506 5 5 1.000 0.001 TF:M07249_0 tf 1 Factor: ctcf; motif: CCNCNAGRKGGCRSTN; match class: 0 1 Q16181,Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 4.18e-02 3521 5 4 0.800 0.001 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 Q16181,Q92599,Q9H3Q1,Q9UHD8 426 4.19e-02 3523 5 4 0.800 0.001 HPA:039040_01 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Low] 1 Q16181,Q9H3Q1,Q9UHD8,Q9P0V9 426 4.25e-02 409 5 2 0.400 0.005 GO:0044463 CC 1 cell projection part 1 Q16181,Q9UHD8 426 4.40e-02 5782 5 5 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 Q16181,Q92599,Q9H3Q1,Q9UHD8,Q9P0V9 426 4.85e-02 179 5 2 0.400 0.011 TF:M06744_0 tf 1 Factor: ZNF228; motif: NACTAAAKCAGR; match class: 0 1 Q92599,Q9H3Q1 426 4.88e-02 3675 5 4 0.800 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 Q16181,Q9H3Q1,Q9UHD8,Q9P0V9 426 5.00e-02 765 5 3 0.600 0.004 TF:M07249_1 tf 1 Factor: ctcf; motif: CCNCNAGRKGGCRSTN; match class: 1 1 Q92599,Q9H3Q1,Q9P0V9 426 5.00e-02 1 5 1 0.200 1.000 HP:0410009 hp 1 Abnormality of the somatic nervous system 1 Q9UHD8 426 5.00e-02 1 5 1 0.200 1.000 HP:0045052 hp 1 Abnormality of the brachial nerve plexus 1 Q9UHD8 426 5.00e-02 5 5 3 0.600 0.600 CORUM:1345 cor 1 Septin complex 1 Q16181,Q92599,Q9UHD8 426 5.00e-02 445 5 2 0.400 0.004 GO:0070925 BP 1 organelle assembly 1 Q16181,Q9UHD8 426 5.00e-02 73 5 2 0.400 0.027 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 Q92599,Q9UHD8 426 5.00e-02 1 5 1 0.200 1.000 HP:0045054 hp 1 Brachial plexus neuropathy 1 Q9UHD8 426 5.00e-02 1 5 1 0.200 1.000 HP:0410010 hp 1 Abnormality of somatic nerve plexus 1 Q9UHD8 427 4.01e-12 22 7 5 0.714 0.227 REAC:167242 rea 1 Abortive elongation of HIV-1 transcript in the absence of Tat 1 P30876,P19388,P13984,O00267,P63272 427 9.71e-12 37 7 5 0.714 0.135 GO:0050434 BP 1 positive regulation of viral transcription 1 P30876,P19388,P13984,O00267,P63272 427 2.58e-11 31 7 5 0.714 0.161 REAC:167238 rea 1 Pausing and recovery of Tat-mediated HIV elongation 1 P30876,P19388,P13984,O00267,P63272 427 2.58e-11 31 7 5 0.714 0.161 REAC:167243 rea 1 Tat-mediated HIV elongation arrest and recovery 1 P30876,P19388,P13984,O00267,P63272 427 3.06e-11 32 7 5 0.714 0.156 REAC:113418 rea 1 Formation of the Early Elongation Complex 1 P30876,P19388,P13984,O00267,P63272 427 3.06e-11 32 7 5 0.714 0.156 REAC:167290 rea 1 Pausing and recovery of HIV elongation 1 P30876,P19388,P13984,O00267,P63272 427 3.06e-11 32 7 5 0.714 0.156 REAC:167158 rea 1 Formation of the HIV-1 Early Elongation Complex 1 P30876,P19388,P13984,O00267,P63272 427 3.06e-11 32 7 5 0.714 0.156 REAC:167287 rea 1 HIV elongation arrest and recovery 1 P30876,P19388,P13984,O00267,P63272 427 5.22e-11 51 7 5 0.714 0.098 GO:0046782 BP 1 regulation of viral transcription 1 P30876,P19388,P13984,O00267,P63272 427 1.46e-10 43 7 5 0.714 0.116 REAC:167246 rea 1 Tat-mediated elongation of the HIV-1 transcript 1 P30876,P19388,P13984,O00267,P63272 427 1.46e-10 43 7 5 0.714 0.116 REAC:167200 rea 1 Formation of HIV-1 elongation complex containing HIV-1 Tat 1 P30876,P19388,P13984,O00267,P63272 427 1.46e-10 43 7 5 0.714 0.116 REAC:167169 rea 1 HIV Transcription Elongation 1 P30876,P19388,P13984,O00267,P63272 427 1.65e-10 44 7 5 0.714 0.114 REAC:167152 rea 1 Formation of HIV elongation complex in the absence of HIV Tat 1 P30876,P19388,P13984,O00267,P63272 427 4.68e-10 78 7 5 0.714 0.064 GO:1903902 BP 1 positive regulation of viral life cycle 1 P30876,P19388,P13984,O00267,P63272 427 6.33e-10 57 7 5 0.714 0.088 REAC:112382 rea 1 Formation of RNA Pol II elongation complex 1 P30876,P19388,P13984,O00267,P63272 427 6.33e-10 57 7 5 0.714 0.088 REAC:75955 rea 1 RNA Polymerase II Transcription Elongation 1 P30876,P19388,P13984,O00267,P63272 427 6.43e-10 83 7 5 0.714 0.060 GO:0048524 BP 1 positive regulation of viral process 1 P30876,P19388,P13984,O00267,P63272 427 8.25e-10 60 7 5 0.714 0.083 REAC:6796648 rea 1 TP53 Regulates Transcription of DNA Repair Genes 1 P30876,P19388,P13984,O00267,P63272 427 9.18e-10 89 7 5 0.714 0.056 GO:0006368 BP 1 transcription elongation from RNA polymerase II promoter 1 P30876,P19388,P13984,O00267,P63272 427 1.28e-09 95 7 5 0.714 0.053 GO:0043902 BP 1 positive regulation of multi-organism process 1 P30876,P19388,P13984,O00267,P63272 427 1.69e-09 69 7 5 0.714 0.072 REAC:167172 rea 1 Transcription of the HIV genome 1 P30876,P19388,P13984,O00267,P63272 427 3.08e-09 32 7 4 0.571 0.125 GO:0006370 BP 1 7-methylguanosine mRNA capping 1 P30876,P19388,P13984,O00267 427 3.38e-09 115 7 5 0.714 0.043 GO:0006354 BP 1 DNA-templated transcription, elongation 1 P30876,P19388,P13984,O00267,P63272 427 3.39e-09 79 7 5 0.714 0.063 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 P30876,P19388,P13984,O00267,P63272 427 3.96e-09 34 7 4 0.571 0.118 GO:0009452 BP 1 7-methylguanosine RNA capping 1 P30876,P19388,P13984,O00267 427 4.48e-09 35 7 4 0.571 0.114 GO:0036260 BP 1 RNA capping 1 P30876,P19388,P13984,O00267 427 6.41e-09 27 7 4 0.571 0.148 REAC:77075 rea 1 RNA Pol II CTD phosphorylation and interaction with CE 1 P30876,P19388,P13984,O00267 427 7.33e-09 134 7 5 0.714 0.037 GO:1903900 BP 1 regulation of viral life cycle 1 P30876,P19388,P13984,O00267,P63272 427 8.67e-09 29 7 4 0.571 0.138 REAC:72086 rea 1 mRNA Capping 1 P30876,P19388,P13984,O00267 427 1.06e-08 144 7 5 0.714 0.035 GO:0050792 BP 1 regulation of viral process 1 P30876,P19388,P13984,O00267,P63272 427 1.43e-08 153 7 5 0.714 0.033 GO:0043903 BP 1 regulation of symbiosis, encompassing mutualism through parasitism 1 P30876,P19388,P13984,O00267,P63272 427 2.03e-08 164 7 5 0.714 0.030 GO:0019083 BP 1 viral transcription 1 P30876,P19388,P13984,O00267,P63272 427 2.37e-08 169 7 5 0.714 0.030 GO:0043900 BP 1 regulation of multi-organism process 1 P30876,P19388,P13984,O00267,P63272 427 2.82e-08 175 7 5 0.714 0.029 GO:0019080 BP 1 viral gene expression 1 P30876,P19388,P13984,O00267,P63272 427 4.09e-08 129 7 5 0.714 0.039 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 P30876,P19388,P13984,O00267,P63272 427 4.61e-08 193 7 5 0.714 0.026 GO:0044033 BP 1 multi-organism metabolic process 1 P30876,P19388,P13984,O00267,P63272 427 6.18e-08 140 7 5 0.714 0.036 REAC:162587 rea 1 HIV Life Cycle 1 P30876,P19388,P13984,O00267,P63272 427 6.18e-08 140 7 5 0.714 0.036 REAC:73857 rea 1 RNA Polymerase II Transcription 1 P30876,P19388,P13984,O00267,P63272 427 2.36e-07 92 7 4 0.571 0.043 GO:0098781 BP 1 ncRNA transcription 1 P30876,P19388,P19338,P13984 427 3.80e-07 22 7 3 0.429 0.136 GO:0032786 BP 1 positive regulation of DNA-templated transcription, elongation 1 P13984,O00267,P63272 427 5.72e-07 2 7 2 0.286 1.000 GO:0032044 CC 1 DSIF complex 1 O00267,P63272 427 5.83e-07 219 7 5 0.714 0.023 REAC:162906 rea 1 HIV Infection 1 P30876,P19388,P13984,O00267,P63272 427 6.40e-07 19 7 3 0.429 0.158 REAC:8851708 rea 1 Signaling by FGFR2 IIIa TM 1 P30876,P19388,P13984 427 7.95e-07 341 7 5 0.714 0.015 GO:0019058 BP 1 viral life cycle 1 P30876,P19388,P13984,O00267,P63272 427 9.77e-07 762 7 6 0.857 0.008 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.22e-06 791 7 6 0.857 0.008 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.24e-06 373 7 5 0.714 0.013 GO:0016032 BP 1 viral process 1 P30876,P19388,P13984,O00267,P63272 427 1.28e-06 375 7 5 0.714 0.013 GO:0044764 BP 1 multi-organism cellular process 1 P30876,P19388,P13984,O00267,P63272 427 1.33e-06 24 7 3 0.429 0.125 REAC:1839126 rea 1 FGFR2 mutant receptor activation 1 P30876,P19388,P13984 427 1.47e-06 386 7 5 0.714 0.013 GO:0044403 BP 1 symbiosis, encompassing mutualism through parasitism 1 P30876,P19388,P13984,O00267,P63272 427 1.47e-06 386 7 5 0.714 0.013 GO:0044419 BP 1 interspecies interaction between organisms 1 P30876,P19388,P13984,O00267,P63272 427 1.76e-06 36 7 3 0.429 0.083 GO:0032784 BP 1 regulation of DNA-templated transcription, elongation 1 P13984,O00267,P63272 427 1.93e-06 27 7 3 0.429 0.111 REAC:6803529 rea 1 FGFR2 alternative splicing 1 P30876,P19388,P13984 427 2.56e-06 896 7 6 0.857 0.007 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.04e-06 922 7 6 0.857 0.007 GO:0010628 BP 1 positive regulation of gene expression 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.26e-06 933 7 6 0.857 0.006 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.77e-06 956 7 6 0.857 0.006 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.93e-06 34 7 3 0.429 0.088 REAC:5655253 rea 1 Signaling by FGFR2 in disease 1 P30876,P19388,P13984 427 4.13e-06 971 7 6 0.857 0.006 GO:0009891 BP 1 positive regulation of biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 4.55e-06 331 7 5 0.714 0.015 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 P30876,P19388,P13984,O00267,P63272 427 4.72e-06 993 7 6 0.857 0.006 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 5.67e-06 346 7 5 0.714 0.014 REAC:5663205 rea 1 Infectious disease 1 P30876,P19388,P13984,O00267,P63272 427 6.51e-06 521 7 5 0.714 0.010 GO:0044451 CC 1 nucleoplasm part 1 P30876,P19388,P13984,O00267,P63272 427 7.51e-06 42 7 3 0.429 0.071 REAC:168325 rea 1 Viral Messenger RNA Synthesis 1 P30876,P19388,P13984 427 9.48e-06 2 7 2 0.286 1.000 CORUM:2861 cor 1 DSIF complex (DRB sensitivity-inducing factor complex) 1 O00267,P63272 427 9.48e-06 2 7 2 0.286 1.000 CORUM:2860 cor 1 DSIF complex (DRB sensitivity-inducing factor complex) 1 O00267,P63272 427 9.91e-06 46 7 3 0.429 0.065 REAC:75953 rea 1 RNA Polymerase II Transcription Initiation 1 P30876,P19388,P13984 427 9.91e-06 46 7 3 0.429 0.065 REAC:73779 rea 1 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1 P30876,P19388,P13984 427 9.91e-06 46 7 3 0.429 0.065 REAC:167162 rea 1 RNA Polymerase II HIV Promoter Escape 1 P30876,P19388,P13984 427 9.91e-06 46 7 3 0.429 0.065 REAC:73776 rea 1 RNA Polymerase II Promoter Escape 1 P30876,P19388,P13984 427 9.91e-06 46 7 3 0.429 0.065 REAC:167161 rea 1 HIV Transcription Initiation 1 P30876,P19388,P13984 427 9.91e-06 46 7 3 0.429 0.065 REAC:76042 rea 1 RNA Polymerase II Transcription Initiation And Promoter Clearance 1 P30876,P19388,P13984 427 1.28e-05 69 7 3 0.429 0.043 GO:0008543 BP 1 fibroblast growth factor receptor signaling pathway 1 P30876,P19388,P13984 427 1.33e-05 70 7 3 0.429 0.043 GO:0009301 BP 1 snRNA transcription 1 P30876,P19388,P13984 427 1.33e-05 70 7 3 0.429 0.043 GO:0042795 BP 1 snRNA transcription from RNA polymerase II promoter 1 P30876,P19388,P13984 427 1.36e-05 51 7 3 0.429 0.059 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 P30876,P19388,P13984 427 1.38e-05 17 7 3 0.429 0.176 CORUM:2685 cor 1 RNA polymerase II (RNAPII) 1 P30876,P19388,P13984 427 1.60e-05 8 7 2 0.286 0.250 GO:0032785 BP 1 negative regulation of DNA-templated transcription, elongation 1 O00267,P63272 427 1.61e-05 54 7 3 0.429 0.056 REAC:1226099 rea 1 Signaling by FGFR in disease 1 P30876,P19388,P13984 427 1.85e-05 78 7 3 0.429 0.038 GO:0044344 BP 1 cellular response to fibroblast growth factor stimulus 1 P30876,P19388,P13984 427 1.94e-05 650 7 5 0.714 0.008 GO:0051704 BP 1 multi-organism process 1 P30876,P19388,P13984,O00267,P63272 427 2.00e-05 80 7 3 0.429 0.037 GO:0071774 BP 1 response to fibroblast growth factor 1 P30876,P19388,P13984 427 2.31e-05 84 7 3 0.429 0.036 GO:0016073 BP 1 snRNA metabolic process 1 P30876,P19388,P13984 427 2.57e-05 10 7 2 0.286 0.200 GO:0001055 MF 1 RNA polymerase II activity 1 P30876,P19388 427 3.04e-05 92 7 3 0.429 0.033 GO:0016591 CC 1 DNA-directed RNA polymerase II, holoenzyme 1 P30876,P19388,P13984 427 3.54e-05 70 7 3 0.429 0.043 REAC:6807505 rea 1 RNA polymerase II transcribes snRNA genes 1 P30876,P19388,P13984 427 4.06e-05 24 7 3 0.429 0.125 CORUM:103 cor 1 RNA polymerase II holoenzyme complex 1 P30876,P19388,P13984 427 4.49e-05 342 7 4 0.571 0.012 GO:0006397 BP 1 mRNA processing 1 P30876,P19388,P13984,O00267 427 5.20e-05 26 7 3 0.429 0.115 CORUM:2825 cor 1 BRCA1-RNA polymerase II complex 1 P30876,P19388,P13984 427 5.79e-05 114 7 3 0.429 0.026 GO:0000428 CC 1 DNA-directed RNA polymerase complex 1 P30876,P19388,P13984 427 5.79e-05 114 7 3 0.429 0.026 GO:0055029 CC 1 nuclear DNA-directed RNA polymerase complex 1 P30876,P19388,P13984 427 5.98e-05 15 7 2 0.286 0.133 GO:0005665 CC 1 DNA-directed RNA polymerase II, core complex 1 P30876,P19388 427 6.10e-05 116 7 3 0.429 0.026 GO:0030880 CC 1 RNA polymerase complex 1 P30876,P19388,P13984 427 8.97e-05 1635 7 6 0.857 0.004 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 9.26e-05 1644 7 6 0.857 0.004 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 9.44e-05 5 7 2 0.286 0.400 CORUM:1191 cor 1 RNA pol II containing coactivator complex Tat-SF 1 P19338,O00267 427 9.82e-05 136 7 3 0.429 0.022 GO:0006367 BP 1 transcription initiation from RNA polymerase II promoter 1 P30876,P19388,P13984 427 1.06e-04 628 7 5 0.714 0.008 REAC:212436 rea 1 Generic Transcription Pathway 1 P30876,P19388,P13984,O00267,P63272 427 1.06e-04 1681 7 6 0.857 0.004 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.31e-04 1745 7 6 0.857 0.003 GO:0009893 BP 1 positive regulation of metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.45e-04 1775 7 6 0.857 0.003 GO:0051252 BP 1 regulation of RNA metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.87e-04 492 7 4 0.571 0.008 GO:0034660 BP 1 ncRNA metabolic process 1 P30876,P19388,P19338,P13984 427 1.94e-04 1865 7 6 0.857 0.003 GO:0006351 BP 1 transcription, DNA-templated 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.94e-04 171 7 3 0.429 0.018 GO:0006352 BP 1 DNA-templated transcription, initiation 1 P30876,P19388,P13984 427 1.98e-04 1872 7 6 0.857 0.003 GO:0097659 BP 1 nucleic acid-templated transcription 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.05e-04 720 7 5 0.714 0.007 REAC:1643685 rea 1 Disease 1 P30876,P19388,P13984,O00267,P63272 427 2.36e-04 522 7 4 0.571 0.008 GO:0016071 BP 1 mRNA metabolic process 1 P30876,P19388,P13984,O00267 427 2.36e-04 132 7 3 0.429 0.023 REAC:168273 rea 1 Influenza Viral RNA Transcription and Replication 1 P30876,P19388,P13984 427 2.41e-04 23 7 2 0.286 0.087 REAC:203927 rea 1 MicroRNA (miRNA) biogenesis 1 P30876,P19388 427 2.72e-04 1976 7 6 0.857 0.003 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.75e-04 1980 7 6 0.857 0.003 GO:0032774 BP 1 RNA biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.81e-04 140 7 3 0.429 0.021 REAC:168255 rea 1 Influenza Life Cycle 1 P30876,P19388,P13984 427 2.87e-04 1994 7 6 0.857 0.003 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.99e-04 33 7 2 0.286 0.061 GO:0035019 BP 1 somatic stem cell population maintenance 1 P30876,P19388 427 3.33e-04 27 7 2 0.286 0.074 REAC:5601884 rea 1 PIWI-interacting RNA (piRNA) biogenesis 1 P30876,P19388 427 3.50e-04 1177 7 5 0.714 0.004 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 P30876,P19388,P13984,O00267,P63272 427 3.52e-04 151 7 3 0.429 0.020 REAC:168254 rea 1 Influenza Infection 1 P30876,P19388,P13984 427 3.55e-04 2068 7 6 0.857 0.003 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.77e-04 2090 7 6 0.857 0.003 GO:0009889 BP 1 regulation of biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.89e-04 216 7 3 0.429 0.014 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 P30876,P19388,P13984 427 3.98e-04 38 7 2 0.286 0.053 GO:0003899 MF 1 DNA-directed 5'-3' RNA polymerase activity 1 P30876,P19388 427 4.41e-04 40 7 2 0.286 0.050 GO:0097747 MF 1 RNA polymerase activity 1 P30876,P19388 427 4.41e-04 40 7 2 0.286 0.050 GO:0034062 MF 1 5'-3' RNA polymerase activity 1 P30876,P19388 427 4.73e-04 2173 7 6 0.857 0.003 GO:0010468 BP 1 regulation of gene expression 1 P30876,P19388,P19338,P13984,O00267,P63272 427 4.98e-04 2192 7 6 0.857 0.003 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 5.00e-04 33 7 2 0.286 0.061 REAC:452723 rea 1 Transcriptional regulation of pluripotent stem cells 1 P30876,P19388 427 5.25e-04 173 7 3 0.429 0.017 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P30876,P19388,P13984 427 5.90e-04 180 7 3 0.429 0.017 REAC:72172 rea 1 mRNA Splicing 1 P30876,P19388,P13984 427 6.05e-04 2267 7 6 0.857 0.003 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 6.17e-04 12 7 2 0.286 0.167 CORUM:104 cor 1 RNA polymerase II core complex 1 P30876,P19388 427 6.37e-04 48 7 2 0.286 0.042 GO:0008023 CC 1 transcription elongation factor complex 1 O00267,P63272 427 6.66e-04 2305 7 6 0.857 0.003 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 6.75e-04 2310 7 6 0.857 0.003 GO:0018130 BP 1 heterocycle biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 7.10e-04 265 7 3 0.429 0.011 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P30876,P19388,P13984 427 7.10e-04 265 7 3 0.429 0.011 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P30876,P19388,P13984 427 7.19e-04 51 7 2 0.286 0.039 GO:0006360 BP 1 transcription from RNA polymerase I promoter 1 P19388,P19338 427 7.28e-04 13 7 2 0.286 0.154 CORUM:2686 cor 1 BRCA1-core RNA polymerase II complex 1 P30876,P19388 427 7.42e-04 269 7 3 0.429 0.011 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P30876,P19388,P13984 427 7.90e-04 2374 7 6 0.857 0.003 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 9.16e-04 741 7 4 0.571 0.005 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 P19338,P13984,O00267,P63272 427 9.16e-04 741 7 4 0.571 0.005 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 P19338,P13984,O00267,P63272 427 9.63e-04 59 7 2 0.286 0.034 GO:0098727 BP 1 maintenance of cell number 1 P30876,P19388 427 9.63e-04 59 7 2 0.286 0.034 GO:0019827 BP 1 stem cell population maintenance 1 P30876,P19388 427 9.70e-04 752 7 4 0.571 0.005 GO:0006396 BP 1 RNA processing 1 P30876,P19388,P13984,O00267 427 1.14e-03 2529 7 6 0.857 0.002 GO:0005654 CC 1 nucleoplasm 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.18e-03 228 7 3 0.429 0.013 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P30876,P19388,P13984 427 1.19e-03 316 7 3 0.429 0.009 GO:0071363 BP 1 cellular response to growth factor stimulus 1 P30876,P19388,P13984 427 1.24e-03 52 7 2 0.286 0.038 REAC:6781823 rea 1 Formation of TC-NER Pre-Incision Complex 1 P30876,P19388 427 1.30e-03 326 7 3 0.429 0.009 GO:0070848 BP 1 response to growth factor 1 P30876,P19388,P13984 427 1.30e-03 326 7 3 0.429 0.009 GO:0008380 BP 1 RNA splicing 1 P30876,P19388,P13984 427 1.40e-03 1179 7 5 0.714 0.004 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.42e-03 2627 7 6 0.857 0.002 GO:0016070 BP 1 RNA metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.43e-03 72 7 2 0.286 0.028 GO:0006283 BP 1 transcription-coupled nucleotide-excision repair 1 P30876,P19388 427 1.60e-03 59 7 2 0.286 0.034 REAC:5578749 rea 1 Transcriptional regulation by small RNAs 1 P30876,P19388 427 1.63e-03 861 7 4 0.571 0.005 GO:0010629 BP 1 negative regulation of gene expression 1 P30876,P19388,O00267,P63272 427 1.69e-03 2707 7 6 0.857 0.002 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.82e-03 63 7 2 0.286 0.032 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 P30876,P19388 427 1.83e-03 1247 7 5 0.714 0.004 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.84e-03 631 7 4 0.571 0.006 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 P30876,P19388,P19338,P13984 427 1.88e-03 64 7 2 0.286 0.031 REAC:6782135 rea 1 Dual incision in TC-NER 1 P30876,P19388 427 1.89e-03 2761 7 6 0.857 0.002 GO:0048522 BP 1 positive regulation of cellular process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.92e-03 2770 7 6 0.857 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.08e-03 30 7 2 0.286 0.067 KEGG:03020 keg 1 RNA polymerase 1 P30876,P19388 427 2.12e-03 68 7 2 0.286 0.029 REAC:5619507 rea 1 Activation of HOX genes during differentiation 1 P30876,P19388 427 2.12e-03 68 7 2 0.286 0.029 REAC:5617472 rea 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis 1 P30876,P19388 427 2.20e-03 2 7 1 0.143 0.500 GO:0000990 MF 1 transcription factor activity, core RNA polymerase binding 1 P13984 427 2.20e-03 2 7 1 0.143 0.500 GO:0000991 MF 1 transcription factor activity, core RNA polymerase II binding 1 P13984 427 2.20e-03 2 7 1 0.143 0.500 GO:0005674 CC 1 transcription factor TFIIF complex 1 P13984 427 2.30e-03 1307 7 5 0.714 0.004 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.35e-03 2869 7 6 0.857 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.38e-03 1317 7 5 0.714 0.004 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.66e-03 2931 7 6 0.857 0.002 GO:0031981 CC 1 nuclear lumen 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.72e-03 77 7 2 0.286 0.026 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 P30876,P19388 427 2.85e-03 309 7 3 0.429 0.010 REAC:5663202 rea 1 Diseases of signal transduction 1 P30876,P19388,P13984 427 2.85e-03 309 7 3 0.429 0.010 REAC:5654738 rea 1 Signaling by FGFR2 1 P30876,P19388,P13984 427 2.90e-03 311 7 3 0.429 0.010 REAC:190236 rea 1 Signaling by FGFR 1 P30876,P19388,P13984 427 2.96e-03 432 7 3 0.429 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 P30876,P19388,P13984 427 3.02e-03 2997 7 6 0.857 0.002 GO:0080090 BP 1 regulation of primary metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.03e-03 105 7 2 0.286 0.019 GO:0016779 MF 1 nucleotidyltransferase activity 1 P30876,P19388 427 3.12e-03 3013 7 6 0.857 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.14e-03 1396 7 5 0.714 0.004 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 3.15e-03 107 7 2 0.286 0.019 GO:0006289 BP 1 nucleotide-excision repair 1 P30876,P19388 427 3.17e-03 3022 7 6 0.857 0.002 GO:0031323 BP 1 regulation of cellular metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.22e-03 730 7 4 0.571 0.005 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 P19388,P19338,P13984,O00267 427 3.24e-03 3033 7 6 0.857 0.002 GO:0048518 BP 1 positive regulation of biological process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.32e-03 110 7 2 0.286 0.018 GO:0031047 BP 1 gene silencing by RNA 1 P30876,P19388 427 3.38e-03 86 7 2 0.286 0.023 REAC:211000 rea 1 Gene Silencing by RNA 1 P30876,P19388 427 3.39e-03 3058 7 6 0.857 0.002 GO:0010467 BP 1 gene expression 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.42e-03 3063 7 6 0.857 0.002 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 3.63e-03 115 7 2 0.286 0.017 GO:0006338 BP 1 chromatin remodeling 1 O00267,P63272 427 3.63e-03 1 7 1 0.143 1.000 CORUM:92 cor 1 CD28-transactivation complex 1 P19338 427 4.02e-03 1470 7 5 0.714 0.003 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 4.15e-03 3168 7 6 0.857 0.002 GO:0044428 CC 1 nuclear part 1 P30876,P19388,P19338,P13984,O00267,P63272 427 4.20e-03 317 7 3 0.429 0.009 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 P30876,P19338,P13984 427 4.31e-03 1492 7 5 0.714 0.003 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.41e-03 1499 7 5 0.714 0.003 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 4.61e-03 1513 7 5 0.714 0.003 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 4.91e-03 3263 7 6 0.857 0.002 GO:0019222 BP 1 regulation of metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 4.93e-03 516 7 3 0.429 0.006 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 P13984,O00267,P63272 427 4.94e-03 1535 7 5 0.714 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 5.38e-03 109 7 2 0.286 0.018 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P30876,P19388 427 5.49e-03 5 7 1 0.143 0.200 GO:0039692 BP 1 single stranded viral RNA replication via double stranded DNA intermediate 1 O00267 427 5.56e-03 1574 7 5 0.714 0.003 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 5.71e-03 1583 7 5 0.714 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 5.82e-03 1589 7 5 0.714 0.003 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 6.01e-03 1600 7 5 0.714 0.003 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 6.29e-03 1485 7 5 0.714 0.003 REAC:74160 rea 1 Gene Expression 1 P30876,P19388,P13984,O00267,P63272 427 6.35e-03 1619 7 5 0.714 0.003 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 6.36e-03 3415 7 6 0.857 0.002 GO:0032991 CC 1 macromolecular complex 1 P30876,P19388,P19338,P13984,O00267,P63272 427 6.39e-03 1621 7 5 0.714 0.003 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 6.41e-03 1622 7 5 0.714 0.003 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 6.66e-03 3443 7 6 0.857 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 7.13e-03 1659 7 5 0.714 0.003 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 7.21e-03 902 7 4 0.571 0.004 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P30876,P19388,P19338,P13984 427 7.26e-03 2 7 1 0.143 0.500 CORUM:153 cor 1 TFIIF complex (transcription factor IIF) 1 P13984 427 7.26e-03 2 7 1 0.143 0.500 CORUM:3078 cor 1 DGCR8-NCL complex 1 P19338 427 7.29e-03 3499 7 6 0.857 0.002 GO:0044249 BP 1 cellular biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 7.34e-03 906 7 4 0.571 0.004 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P30876,P19388,P19338,P13984 427 7.34e-03 593 7 3 0.429 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 P30876,P19388,P13984 427 7.38e-03 165 7 2 0.286 0.012 GO:0016458 BP 1 gene silencing 1 P30876,P19388 427 7.69e-03 7 7 1 0.143 0.143 GO:1901838 BP 1 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter 1 P19338 427 7.97e-03 3554 7 6 0.857 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.06e-03 3561 7 6 0.857 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.06e-03 3561 7 6 0.857 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.06e-03 3561 7 6 0.857 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.06e-03 3561 7 6 0.857 0.002 GO:0043233 CC 1 organelle lumen 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.07e-03 1317 7 4 0.571 0.003 GO:0010605 BP 1 negative regulation of macromolecule metabolic process 1 P30876,P19388,O00267,P63272 427 8.10e-03 930 7 4 0.571 0.004 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P19388,P19338,P13984,O00267 427 8.15e-03 1707 7 5 0.714 0.003 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 8.16e-03 3569 7 6 0.857 0.002 GO:1901576 BP 1 organic substance biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 8.48e-03 624 7 3 0.429 0.005 GO:1990234 CC 1 transferase complex 1 P30876,P19388,P13984 427 8.66e-03 179 7 2 0.286 0.011 GO:0046982 MF 1 protein heterodimerization activity 1 O00267,P63272 427 8.78e-03 8 7 1 0.143 0.125 GO:1900364 BP 1 negative regulation of mRNA polyadenylation 1 O00267 427 8.84e-03 3620 7 6 0.857 0.002 GO:0009058 BP 1 biosynthetic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 9.06e-03 958 7 4 0.571 0.004 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 9.23e-03 643 7 3 0.429 0.005 GO:0071495 BP 1 cellular response to endogenous stimulus 1 P30876,P19388,P13984 427 9.31e-03 965 7 4 0.571 0.004 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P30876,P19338,P13984,O00267 427 9.54e-03 1765 7 5 0.714 0.003 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 9.71e-03 3681 7 6 0.857 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 9.88e-03 9 7 1 0.143 0.111 GO:0031441 BP 1 negative regulation of mRNA 3'-end processing 1 O00267 427 9.88e-03 9 7 1 0.143 0.111 GO:1901836 BP 1 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter 1 P19338 427 9.96e-03 1394 7 4 0.571 0.003 GO:0010033 BP 1 response to organic substance 1 P30876,P19388,P13984,O00267 427 9.98e-03 1782 7 5 0.714 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.01e-02 1787 7 5 0.714 0.003 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.01e-02 1788 7 5 0.714 0.003 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.04e-02 670 7 3 0.429 0.004 GO:0006259 BP 1 DNA metabolic process 1 P30876,P19388,O00267 427 1.04e-02 994 7 4 0.571 0.004 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P30876,P19388,P19338,P13984 427 1.05e-02 1803 7 5 0.714 0.003 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.07e-02 1002 7 4 0.571 0.004 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 1.08e-02 1424 7 4 0.571 0.003 GO:0009892 BP 1 negative regulation of metabolic process 1 P30876,P19388,O00267,P63272 427 1.08e-02 1813 7 5 0.714 0.003 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.09e-02 3 7 1 0.143 0.333 CORUM:2812 cor 1 RPAP1-RPB2-RPB3 complex 1 P30876 427 1.09e-02 3 7 1 0.143 0.333 CORUM:2603 cor 1 Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) 1 O00267 427 1.10e-02 1818 7 5 0.714 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.10e-02 10 7 1 0.143 0.100 GO:0042790 BP 1 transcription of nuclear large rRNA transcript from RNA polymerase I promoter 1 P19338 427 1.10e-02 10 7 1 0.143 0.100 GO:0060261 BP 1 positive regulation of transcription initiation from RNA polymerase II promoter 1 P13984 427 1.10e-02 1820 7 5 0.714 0.003 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.12e-02 1825 7 5 0.714 0.003 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.19e-02 454 7 3 0.429 0.007 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 P30876,P19338,P13984 427 1.21e-02 11 7 1 0.143 0.091 GO:1900363 BP 1 regulation of mRNA polyadenylation 1 O00267 427 1.21e-02 1857 7 5 0.714 0.003 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.23e-02 712 7 3 0.429 0.004 GO:0009719 BP 1 response to endogenous stimulus 1 P30876,P19388,P13984 427 1.28e-02 1880 7 5 0.714 0.003 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.29e-02 1883 7 5 0.714 0.003 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.30e-02 1885 7 5 0.714 0.003 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.32e-02 12 7 1 0.143 0.083 GO:0005736 CC 1 DNA-directed RNA polymerase I complex 1 P19388 427 1.32e-02 12 7 1 0.143 0.083 GO:0001054 MF 1 RNA polymerase I activity 1 P19388 427 1.36e-02 1904 7 5 0.714 0.003 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.38e-02 1909 7 5 0.714 0.003 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.43e-02 13 7 1 0.143 0.077 GO:0032968 BP 1 positive regulation of transcription elongation from RNA polymerase II promoter 1 P13984 427 1.43e-02 1924 7 5 0.714 0.003 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.44e-02 3948 7 6 0.857 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 1.46e-02 1933 7 5 0.714 0.003 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.48e-02 1091 7 4 0.571 0.004 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 1.52e-02 1950 7 5 0.714 0.003 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.53e-02 14 7 1 0.143 0.071 GO:0060260 BP 1 regulation of transcription initiation from RNA polymerase II promoter 1 P13984 427 1.53e-02 14 7 1 0.143 0.071 GO:0045943 BP 1 positive regulation of transcription from RNA polymerase I promoter 1 P19338 427 1.61e-02 1974 7 5 0.714 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.64e-02 15 7 1 0.143 0.067 GO:2000144 BP 1 positive regulation of DNA-templated transcription, initiation 1 P13984 427 1.67e-02 1989 7 5 0.714 0.003 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.67e-02 1990 7 5 0.714 0.003 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.68e-02 1129 7 4 0.571 0.004 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P30876,P19388,P19338,P13984 427 1.69e-02 1996 7 5 0.714 0.003 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.70e-02 1998 7 5 0.714 0.003 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.71e-02 1135 7 4 0.571 0.004 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 1.75e-02 16 7 1 0.143 0.062 GO:0039703 BP 1 RNA replication 1 O00267 427 1.75e-02 16 7 1 0.143 0.062 GO:0039694 BP 1 viral RNA genome replication 1 O00267 427 1.81e-02 2024 7 5 0.714 0.002 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.81e-02 5 7 1 0.143 0.200 CORUM:2599 cor 1 POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex 1 P19338 427 1.81e-02 2026 7 5 0.714 0.002 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.87e-02 1656 7 4 0.571 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 P19338,P13984,O00267,P63272 427 1.87e-02 2039 7 5 0.714 0.002 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.89e-02 2043 7 5 0.714 0.002 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.90e-02 1663 7 4 0.571 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 P19338,P13984,O00267,P63272 427 1.91e-02 2049 7 5 0.714 0.002 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.92e-02 2051 7 5 0.714 0.002 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 1.94e-02 2055 7 5 0.714 0.002 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.96e-02 2060 7 5 0.714 0.002 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 1.97e-02 541 7 3 0.429 0.006 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 P30876,P19388,P19338 427 1.97e-02 18 7 1 0.143 0.056 GO:0031440 BP 1 regulation of mRNA 3'-end processing 1 O00267 427 1.97e-02 18 7 1 0.143 0.056 GO:0001056 MF 1 RNA polymerase III activity 1 P19388 427 1.97e-02 18 7 1 0.143 0.056 GO:0005666 CC 1 DNA-directed RNA polymerase III complex 1 P19388 427 2.01e-02 2071 7 5 0.714 0.002 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.01e-02 2072 7 5 0.714 0.002 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.05e-02 95 7 2 0.286 0.021 KEGG:00240 keg 1 Pyrimidine metabolism 1 P30876,P19388 427 2.07e-02 18 7 1 0.143 0.056 REAC:73780 rea 1 RNA Polymerase III Chain Elongation 1 P19388 427 2.08e-02 2086 7 5 0.714 0.002 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.08e-02 19 7 1 0.143 0.053 GO:0034243 BP 1 regulation of transcription elongation from RNA polymerase II promoter 1 P13984 427 2.08e-02 19 7 1 0.143 0.053 GO:2000142 BP 1 regulation of DNA-templated transcription, initiation 1 P13984 427 2.11e-02 2092 7 5 0.714 0.002 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.15e-02 2102 7 5 0.714 0.002 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.19e-02 2110 7 5 0.714 0.002 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.21e-02 4264 7 6 0.857 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.23e-02 2119 7 5 0.714 0.002 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.25e-02 1221 7 4 0.571 0.003 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 P30876,P19388,P19338,O00267 427 2.29e-02 2130 7 5 0.714 0.002 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.39e-02 2151 7 5 0.714 0.002 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.39e-02 1242 7 4 0.571 0.003 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 2.40e-02 2153 7 5 0.714 0.002 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.41e-02 22 7 1 0.143 0.045 GO:0009303 BP 1 rRNA transcription 1 P19338 427 2.41e-02 22 7 1 0.143 0.045 GO:0006356 BP 1 regulation of transcription from RNA polymerase I promoter 1 P19338 427 2.41e-02 21 7 1 0.143 0.048 REAC:73980 rea 1 RNA Polymerase III Transcription Termination 1 P19388 427 2.43e-02 2159 7 5 0.714 0.002 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.48e-02 2168 7 5 0.714 0.002 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.51e-02 23 7 1 0.143 0.043 GO:0050686 BP 1 negative regulation of mRNA processing 1 O00267 427 2.52e-02 7 7 1 0.143 0.143 CORUM:811 cor 1 FCP1-associated protein complex 1 P30876 427 2.52e-02 7 7 1 0.143 0.143 CORUM:1254 cor 1 Menin-associated histone methyltransferase complex 1 P30876 427 2.52e-02 7 7 1 0.143 0.143 CORUM:810 cor 1 FCP1-associated protein complex 1 P30876 427 2.52e-02 2176 7 5 0.714 0.002 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.56e-02 2183 7 5 0.714 0.002 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.59e-02 2188 7 5 0.714 0.002 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.61e-02 2191 7 5 0.714 0.002 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.63e-02 1274 7 4 0.571 0.003 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P30876,P19388,P19338,P13984 427 2.64e-02 2197 7 5 0.714 0.002 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.67e-02 2202 7 5 0.714 0.002 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.71e-02 2209 7 5 0.714 0.002 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.73e-02 4430 7 6 0.857 0.001 GO:0005634 CC 1 nucleus 1 P30876,P19388,P19338,P13984,O00267,P63272 427 2.74e-02 2215 7 5 0.714 0.002 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 2.74e-02 608 7 3 0.429 0.005 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 P30876,P19388,P19338 427 2.81e-02 2227 7 5 0.714 0.002 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.81e-02 2227 7 5 0.714 0.002 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P30876,P19388,P19338,P13984,O00267 427 2.85e-02 616 7 3 0.429 0.005 HPA:032010_13 hpa 1 salivary gland; glandular cells[Supportive,High] 1 P30876,P19388,P19338 427 2.88e-02 8 7 1 0.143 0.125 CORUM:3135 cor 1 TLE1 corepressor complex (MASH1 promoter-corepressor complex) 1 P19338 427 2.91e-02 970 7 3 0.429 0.003 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 P13984,O00267,P63272 427 2.95e-02 27 7 1 0.143 0.037 GO:1903312 BP 1 negative regulation of mRNA metabolic process 1 O00267 427 2.96e-02 1882 7 4 0.571 0.002 GO:0042221 BP 1 response to chemical 1 P30876,P19388,P13984,O00267 427 2.98e-02 26 7 1 0.143 0.038 REAC:76066 rea 1 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1 P19388 427 3.07e-02 2270 7 5 0.714 0.002 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.07e-02 2271 7 5 0.714 0.002 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.09e-02 634 7 3 0.429 0.005 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 P30876,P19338,P13984 427 3.09e-02 27 7 1 0.143 0.037 REAC:76061 rea 1 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1 P19388 427 3.09e-02 27 7 1 0.143 0.037 REAC:76071 rea 1 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1 P19388 427 3.09e-02 2274 7 5 0.714 0.002 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.09e-02 2274 7 5 0.714 0.002 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.10e-02 2276 7 5 0.714 0.002 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.12e-02 2279 7 5 0.714 0.002 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.12e-02 272 7 2 0.286 0.007 REAC:73894 rea 1 DNA Repair 1 P30876,P19388 427 3.13e-02 2281 7 5 0.714 0.002 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.14e-02 1337 7 4 0.571 0.003 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P19388,P19338,P13984,O00267 427 3.17e-02 2286 7 5 0.714 0.002 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.17e-02 29 7 1 0.143 0.034 GO:0006362 BP 1 transcription elongation from RNA polymerase I promoter 1 P19388 427 3.19e-02 2290 7 5 0.714 0.002 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.19e-02 1923 7 4 0.571 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 P19338,P13984,O00267,P63272 427 3.22e-02 2295 7 5 0.714 0.002 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.24e-02 9 7 1 0.143 0.111 CORUM:781 cor 1 URI complex (Unconventional prefoldin RPB5 Interactor) 1 P19388 427 3.27e-02 30 7 1 0.143 0.033 GO:0016239 BP 1 positive regulation of macroautophagy 1 O00267 427 3.27e-02 30 7 1 0.143 0.033 GO:0042162 MF 1 telomeric DNA binding 1 P19338 427 3.31e-02 2308 7 5 0.714 0.002 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.32e-02 2310 7 5 0.714 0.002 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.35e-02 1360 7 4 0.571 0.003 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P30876,P19388,P19338,O00267 427 3.37e-02 2318 7 5 0.714 0.002 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 P19388,P19338,P13984,O00267,P63272 427 3.38e-02 31 7 1 0.143 0.032 GO:0006363 BP 1 termination of RNA polymerase I transcription 1 P19388 427 3.43e-02 658 7 3 0.429 0.005 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P19388,P19338,P13984 427 3.43e-02 30 7 1 0.143 0.033 REAC:73772 rea 1 RNA Polymerase I Promoter Escape 1 P19388 427 3.44e-02 2328 7 5 0.714 0.002 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.45e-02 1033 7 3 0.429 0.003 GO:1902494 CC 1 catalytic complex 1 P30876,P19388,P13984 427 3.46e-02 1372 7 4 0.571 0.003 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 P19388,P19338,P13984,O00267 427 3.54e-02 2342 7 5 0.714 0.002 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.54e-02 31 7 1 0.143 0.032 REAC:73863 rea 1 RNA Polymerase I Transcription Termination 1 P19388 427 3.59e-02 10 7 1 0.143 0.100 CORUM:1729 cor 1 TLE1 corepressor complex (MASH1 promoter-corepressor complex) 1 P19338 427 3.60e-02 33 7 1 0.143 0.030 GO:0006361 BP 1 transcription initiation from RNA polymerase I promoter 1 P19388 427 3.60e-02 375 7 2 0.286 0.005 GO:0000122 BP 1 negative regulation of transcription from RNA polymerase II promoter 1 O00267,P63272 427 3.68e-02 1396 7 4 0.571 0.003 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 P19388,P19338,P13984,O00267 427 3.70e-02 2366 7 5 0.714 0.002 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.76e-02 384 7 2 0.286 0.005 GO:0006281 BP 1 DNA repair 1 P30876,P19388 427 3.80e-02 1408 7 4 0.571 0.003 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P19388,P19338,P13984,O00267 427 3.84e-02 2385 7 5 0.714 0.002 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.88e-02 34 7 1 0.143 0.029 REAC:76046 rea 1 RNA Polymerase III Transcription Initiation 1 P19388 427 3.91e-02 1419 7 4 0.571 0.003 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P19388,P19338,P13984,O00267 427 3.93e-02 2397 7 5 0.714 0.002 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 3.94e-02 11 7 1 0.143 0.091 CORUM:3082 cor 1 DGCR8 multiprotein complex 1 P19338 427 4.08e-02 2417 7 5 0.714 0.002 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.14e-02 38 7 1 0.143 0.026 GO:0006378 BP 1 mRNA polyadenylation 1 O00267 427 4.14e-02 2425 7 5 0.714 0.002 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.18e-02 2429 7 5 0.714 0.002 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.22e-02 37 7 1 0.143 0.027 REAC:74158 rea 1 RNA Polymerase III Transcription 1 P19388 427 4.22e-02 37 7 1 0.143 0.027 REAC:749476 rea 1 RNA Polymerase III Abortive And Retractive Initiation 1 P19388 427 4.22e-02 2435 7 5 0.714 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.25e-02 39 7 1 0.143 0.026 GO:0043631 BP 1 RNA polyadenylation 1 O00267 427 4.26e-02 1453 7 4 0.571 0.003 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P30876,P19388,P19338,O00267 427 4.27e-02 1118 7 3 0.429 0.003 GO:0044822 MF 1 poly(A) RNA binding 1 P30876,P19338,O00267 427 4.29e-02 713 7 3 0.429 0.004 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P19388,P19338,P13984 427 4.33e-02 1459 7 4 0.571 0.003 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P19388,P19338,P13984,O00267 427 4.37e-02 2454 7 5 0.714 0.002 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.39e-02 2456 7 5 0.714 0.002 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.41e-02 2458 7 5 0.714 0.002 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.50e-02 2469 7 5 0.714 0.002 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.52e-02 2472 7 5 0.714 0.002 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.56e-02 1480 7 4 0.571 0.003 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P19388,P19338,P13984,O00267 427 4.56e-02 2477 7 5 0.714 0.002 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.69e-02 1157 7 3 0.429 0.003 GO:0071310 BP 1 cellular response to organic substance 1 P30876,P19388,P13984 427 4.72e-02 2495 7 5 0.714 0.002 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.72e-02 2496 7 5 0.714 0.002 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 4.80e-02 2505 7 5 0.714 0.002 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 P30876,P19388,P19338,P13984,O00267 427 5.00e-02 397 7 3 0.429 0.008 MI:hsa-miR-203 mi 1 MI:hsa-miR-203 1 P30876,P19338,Q8TBY0 427 5.00e-02 46 7 1 0.143 0.022 GO:0045815 BP 1 positive regulation of gene expression, epigenetic 1 P19388 427 5.00e-02 189 7 3 0.429 0.016 TF:M00738_1 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 1 1 P19338,Q8TBY0,P13984 427 5.00e-02 753 7 3 0.429 0.004 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P30876,P19338,P13984 427 5.00e-02 151 7 2 0.286 0.013 KEGG:00230 keg 1 Purine metabolism 1 P30876,P19388 427 5.00e-02 14 7 1 0.143 0.071 CORUM:1155 cor 1 Integrator-RNAPII complex 1 P30876 427 5.00e-02 44 7 1 0.143 0.023 REAC:73777 rea 1 RNA Polymerase I Chain Elongation 1 P19388 428 9.53e-06 21 2 2 1.000 0.095 REAC:379726 rea 1 Mitochondrial tRNA aminoacylation 1 Q9NP81,P49590 428 3.91e-05 42 2 2 1.000 0.048 REAC:379724 rea 1 tRNA Aminoacylation 1 Q9NP81,P49590 428 4.85e-05 42 2 2 1.000 0.048 GO:0016875 MF 1 ligase activity, forming carbon-oxygen bonds 1 Q9NP81,P49590 428 4.85e-05 42 2 2 1.000 0.048 GO:0016876 MF 1 ligase activity, forming aminoacyl-tRNA and related compounds 1 Q9NP81,P49590 428 4.85e-05 42 2 2 1.000 0.048 GO:0004812 MF 1 aminoacyl-tRNA ligase activity 1 Q9NP81,P49590 428 6.09e-05 47 2 2 1.000 0.043 GO:0006418 BP 1 tRNA aminoacylation for protein translation 1 Q9NP81,P49590 428 6.90e-05 50 2 2 1.000 0.040 GO:0043038 BP 1 amino acid activation 1 Q9NP81,P49590 428 6.90e-05 50 2 2 1.000 0.040 GO:0043039 BP 1 tRNA aminoacylation 1 Q9NP81,P49590 428 4.94e-04 133 2 2 1.000 0.015 GO:0016874 MF 1 ligase activity 1 Q9NP81,P49590 428 6.21e-04 149 2 2 1.000 0.013 GO:0006399 BP 1 tRNA metabolic process 1 Q9NP81,P49590 428 1.30e-03 2 2 1 0.500 0.500 GO:0004828 MF 1 serine-tRNA ligase activity 1 Q9NP81 428 1.30e-03 2 2 1 0.500 0.500 GO:0006434 BP 1 seryl-tRNA aminoacylation 1 Q9NP81 428 1.30e-03 2 2 1 0.500 0.500 GO:0004821 MF 1 histidine-tRNA ligase activity 1 P49590 428 1.30e-03 2 2 1 0.500 0.500 GO:0006427 BP 1 histidyl-tRNA aminoacylation 1 P49590 428 1.73e-03 11 2 1 0.500 0.091 TF:M06335_0 tf 1 Factor: ZNF343; motif: NGGGTAGGCAAA; match class: 0 1 P49590 428 2.25e-03 283 2 2 1.000 0.007 GO:0006520 BP 1 cellular amino acid metabolic process 1 Q9NP81,P49590 428 3.32e-03 344 2 2 1.000 0.006 GO:0005759 CC 1 mitochondrial matrix 1 Q9NP81,P49590 428 4.55e-03 1 2 1 0.500 1.000 HP:0005977 hp 1 Hypochloremic metabolic alkalosis 1 Q9NP81 428 6.26e-03 1 2 1 0.500 1.000 OMIM:613845 omi 1 HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSISSYNDROME; HUPRAS;;HUPRA SYNDROME 1 Q9NP81 428 6.26e-03 1 2 1 0.500 1.000 OMIM:614926 omi 1 PERRAULT SYNDROME 2; PRLTS2 1 P49590 428 6.56e-03 483 2 2 1.000 0.004 GO:0006412 BP 1 translation 1 Q9NP81,P49590 428 6.80e-03 492 2 2 1.000 0.004 GO:0034660 BP 1 ncRNA metabolic process 1 Q9NP81,P49590 428 6.97e-03 498 2 2 1.000 0.004 GO:0043043 BP 1 peptide biosynthetic process 1 Q9NP81,P49590 428 8.47e-03 549 2 2 1.000 0.004 GO:0043604 BP 1 amide biosynthetic process 1 Q9NP81,P49590 428 9.56e-03 61 2 1 0.500 0.016 TF:M06332_0 tf 1 Factor: ZNF585A; motif: CACCTGGCTAAC; match class: 0 1 Q9NP81 428 9.85e-03 592 2 2 1.000 0.003 GO:0006518 BP 1 peptide metabolic process 1 Q9NP81,P49590 428 1.03e-02 66 2 1 0.500 0.015 TF:M05546_1 tf 1 Factor: EOS; motif: TGGTTATM; match class: 1 1 P49590 428 1.19e-02 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q9NP81,P49590 428 1.21e-02 77 2 1 0.500 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 P49590 428 1.28e-02 674 2 2 1.000 0.003 GO:0044429 CC 1 mitochondrial part 1 Q9NP81,P49590 428 1.30e-02 83 2 1 0.500 0.012 TF:M01105_0 tf 1 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT; match class: 0 1 Q9NP81 428 1.40e-02 706 2 2 1.000 0.003 GO:0043603 BP 1 cellular amide metabolic process 1 Q9NP81,P49590 428 1.49e-02 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 Q9NP81,P49590 428 1.53e-02 98 2 1 0.500 0.010 TF:M03947_1 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 1 1 Q9NP81 428 1.54e-02 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 Q9NP81,P49590 428 1.80e-02 115 2 1 0.500 0.009 TF:M03947_0 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 0 1 Q9NP81 428 2.00e-02 1802 2 2 1.000 0.001 TF:M03839_0 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 0 1 Q9NP81,P49590 428 2.03e-02 130 2 1 0.500 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 P49590 428 2.03e-02 130 2 1 0.500 0.008 TF:M07328_0 tf 1 Factor: NF-AT5; motif: KGKRWTTTTCCAN; match class: 0 1 Q9NP81 428 2.09e-02 1840 2 2 1.000 0.001 TF:M00351_1 tf 1 Factor: GATA-3; motif: ANAGATMWWA; match class: 1 1 Q9NP81,P49590 428 2.17e-02 139 2 1 0.500 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 Q9NP81 428 2.31e-02 148 2 1 0.500 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 P49590 428 2.34e-02 150 2 1 0.500 0.007 TF:M01725_1 tf 1 Factor: TR4; motif: CSTGACCTYTS; match class: 1 1 P49590 428 2.37e-02 152 2 1 0.500 0.007 TF:M05756_0 tf 1 Factor: ZNF470; motif: NTGTTTAWKAWA; match class: 0 1 Q9NP81 428 2.39e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 Q9NP81 428 2.56e-02 164 2 1 0.500 0.006 TF:M07439_0 tf 1 Factor: TEF; motif: GTTACGTAAT; match class: 0 1 P49590 428 2.62e-02 965 2 2 1.000 0.002 GO:1901566 BP 1 organonitrogen compound biosynthetic process 1 Q9NP81,P49590 428 2.75e-02 2110 2 2 1.000 0.001 TF:M00997_0 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 0 1 Q9NP81,P49590 428 2.93e-02 188 2 1 0.500 0.005 TF:M04212_1 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 1 1 P49590 428 2.98e-02 1029 2 2 1.000 0.002 GO:0005739 CC 1 mitochondrion 1 Q9NP81,P49590 428 3.02e-02 2213 2 2 1.000 0.001 TF:M00191_0 tf 1 Factor: ER; motif: NNARGNCANNNTGACCYNN; match class: 0 1 Q9NP81,P49590 428 3.06e-02 1890 2 2 1.000 0.001 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 Q9NP81,P49590 428 3.12e-02 200 2 1 0.500 0.005 TF:M00997_1 tf 1 Factor: DEC; motif: SCCCAMGTGAAGN; match class: 1 1 Q9NP81 428 3.13e-02 5 2 1 0.500 0.200 OMIM:233400 omi 1 Perrault Syndrome 1 P49590 428 3.14e-02 2256 2 2 1.000 0.001 TF:M04287_1 tf 1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 1 Q9NP81,P49590 428 3.32e-02 213 2 1 0.500 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 P49590 428 3.35e-02 215 2 1 0.500 0.005 TF:M03948_1 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 1 Q9NP81 428 3.50e-02 225 2 1 0.500 0.004 TF:M00191_1 tf 1 Factor: ER; motif: NNARGNCANNNTGACCYNN; match class: 1 1 Q9NP81 428 3.52e-02 1118 2 2 1.000 0.002 GO:0044822 MF 1 poly(A) RNA binding 1 Q9NP81,P49590 428 3.70e-02 238 2 1 0.500 0.004 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 P49590 428 3.71e-02 2451 2 2 1.000 0.001 TF:M00076_1 tf 1 Factor: GATA-2; motif: NNNGATRNNN; match class: 1 1 Q9NP81,P49590 428 3.74e-02 2461 2 2 1.000 0.001 TF:M00436_0 tf 1 Factor: ipf1; motif: GHNNTAATGACM; match class: 0 1 Q9NP81,P49590 428 4.09e-02 9 2 1 0.500 0.111 HP:0000127 hp 1 Renal salt wasting 1 Q9NP81 428 4.09e-02 9 2 1 0.500 0.111 HP:0002149 hp 1 Hyperuricemia 1 Q9NP81 428 4.09e-02 9 2 1 0.500 0.111 HP:0002917 hp 1 Hypomagnesemia 1 Q9NP81 428 4.12e-02 265 2 1 0.500 0.004 TF:M00775_1 tf 1 Factor: NF-Y; motif: NNNNRRCCAATSR; match class: 1 1 Q9NP81 428 4.40e-02 362 2 2 1.000 0.006 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 Q9NP81,P49590 428 4.51e-02 290 2 1 0.500 0.003 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 Q9NP81 428 4.55e-02 10 2 1 0.500 0.100 HP:0004921 hp 1 Abnormality of magnesium homeostasis 1 Q9NP81 428 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q9NP81 428 4.78e-02 308 2 1 0.500 0.003 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 P49590 428 4.79e-02 2787 2 2 1.000 0.001 TF:M02015_1 tf 1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 1 Q9NP81,P49590 428 4.88e-02 2813 2 2 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 Q9NP81,P49590 428 4.89e-02 2816 2 2 1.000 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 Q9NP81,P49590 428 4.92e-02 317 2 1 0.500 0.003 TF:M03982_1 tf 1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 1 P49590 428 5.00e-02 8 2 1 0.500 0.125 OMIM:233300 omi 1 Ovarian Dysgenesis 1 P49590 428 5.00e-02 1485 2 2 1.000 0.001 REAC:74160 rea 1 Gene Expression 1 Q9NP81,P49590 428 5.00e-02 11 2 1 0.500 0.091 HP:0007941 hp 1 Limited extraocular movements 1 P49590 428 5.00e-02 44 2 2 1.000 0.045 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 Q9NP81,P49590 428 5.00e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 Q9NP81,P49590 428 5.00e-02 386 2 2 1.000 0.005 MI:hsa-miR-765 mi 1 MI:hsa-miR-765 1 Q9NP81,P49590 429 1.78e-03 473 2 2 1.000 0.004 MI:mmu-miR-669a mi 1 MI:mmu-miR-669a 1 O14976,Q09019 429 2.52e-03 563 2 2 1.000 0.004 MI:hsa-miR-520a-5p mi 1 MI:hsa-miR-520a-5p 1 O14976,Q09019 429 1.00e-02 2 2 1 0.500 0.500 GO:0072318 BP 1 clathrin coat disassembly 1 O14976 429 1.50e-02 3 2 1 0.500 0.333 GO:0072319 BP 1 vesicle uncoating 1 O14976 429 3.00e-02 6 2 1 0.500 0.167 GO:0090160 BP 1 Golgi to lysosome transport 1 O14976 429 3.50e-02 7 2 1 0.500 0.143 GO:0072600 BP 1 establishment of protein localization to Golgi 1 O14976 429 3.89e-02 56 2 1 0.500 0.018 REAC:432722 rea 1 Golgi Associated Vesicle Biogenesis 1 O14976 429 4.55e-02 258 2 1 0.500 0.004 MI:hsa-miR-214* mi 1 MI:hsa-miR-214* 1 O14976 429 5.00e-02 1 2 1 0.500 1.000 TF:M05623_1 tf 1 Factor: ZNF73; motif: NGNTGGWACAGA; match class: 1 1 O14976 429 5.00e-02 10 2 1 0.500 0.100 GO:0006896 BP 1 Golgi to vacuole transport 1 O14976 429 5.00e-02 72 2 1 0.500 0.014 REAC:421837 rea 1 Clathrin derived vesicle budding 1 O14976 429 5.00e-02 72 2 1 0.500 0.014 REAC:199992 rea 1 trans-Golgi Network Vesicle Budding 1 O14976 430 1.34e-16 265 10 10 1.000 0.038 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.34e-16 265 10 10 1.000 0.038 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.56e-16 269 10 10 1.000 0.037 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.10e-15 326 10 10 1.000 0.031 GO:0008380 BP 1 RNA splicing 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.78e-15 342 10 10 1.000 0.029 GO:0006397 BP 1 mRNA processing 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.51e-14 54 10 7 0.700 0.130 GO:0097525 CC 1 spliceosomal snRNP complex 1 Q96DI7,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 3.71e-14 61 10 7 0.700 0.115 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 Q96DI7,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 6.22e-14 173 10 10 1.000 0.058 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 9.35e-14 180 10 10 1.000 0.056 REAC:72172 rea 1 mRNA Splicing 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 9.78e-14 147 10 8 0.800 0.054 GO:0005681 CC 1 spliceosomal complex 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 1.28e-13 522 10 10 1.000 0.019 GO:0016071 BP 1 mRNA metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.05e-12 228 10 10 1.000 0.044 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 5.07e-12 752 10 10 1.000 0.013 GO:0006396 BP 1 RNA processing 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.50e-11 22 10 5 0.500 0.227 GO:0046540 CC 1 U4/U6 x U5 tri-snRNP complex 1 O94906,Q8WWY3,O43395,O43172,O43290 430 4.59e-11 27 10 5 0.500 0.185 GO:0097526 CC 1 spliceosomal tri-snRNP complex 1 O94906,Q8WWY3,O43395,O43172,O43290 430 6.75e-11 173 10 7 0.700 0.040 GO:0022618 BP 1 ribonucleoprotein complex assembly 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 9.67e-11 182 10 7 0.700 0.038 GO:0071826 BP 1 ribonucleoprotein complex subunit organization 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 8.02e-09 599 10 8 0.800 0.013 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 8.12e-09 600 10 8 0.800 0.013 GO:1990904 CC 1 ribonucleoprotein complex 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 1.96e-08 141 10 9 0.900 0.064 CORUM:351 cor 1 Spliceosome 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.19e-08 394 10 7 0.700 0.018 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 5.04e-08 34 10 4 0.400 0.118 GO:0015030 CC 1 Cajal body 1 Q8WWY3,O43395,O43172,O43290 430 6.40e-08 36 10 4 0.400 0.111 GO:0000387 BP 1 spliceosomal snRNP assembly 1 O94906,Q8WWY3,O43395,O43290 430 3.97e-07 12 10 3 0.300 0.250 GO:0000244 BP 1 spliceosomal tri-snRNP complex assembly 1 O94906,Q8WWY3,O43395 430 7.79e-07 179 10 5 0.500 0.028 GO:0016604 CC 1 nuclear body 1 O60828,Q8WWY3,O43395,O43172,O43290 430 9.78e-07 2529 10 10 1.000 0.004 GO:0005654 CC 1 nucleoplasm 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.01e-06 16 10 3 0.300 0.188 GO:0005682 CC 1 U5 snRNP 1 Q96DI7,O94906,Q9BUQ8 430 1.01e-06 16 10 3 0.300 0.188 GO:0045292 BP 1 mRNA cis splicing, via spliceosome 1 Q9Y2W2,Q9BUQ8,O43290 430 1.04e-06 689 10 7 0.700 0.010 GO:0034622 BP 1 cellular macromolecular complex assembly 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 1.43e-06 2627 10 10 1.000 0.004 GO:0016070 BP 1 RNA metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.48e-06 88 10 4 0.400 0.045 GO:0071013 CC 1 catalytic step 2 spliceosome 1 Q96DI7,O94906,Q9BUQ8,O43290 430 4.29e-06 2931 10 10 1.000 0.003 GO:0031981 CC 1 nuclear lumen 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.46e-06 1336 10 8 0.800 0.006 GO:0003723 MF 1 RNA binding 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 5.65e-06 3013 10 10 1.000 0.003 GO:0090304 BP 1 nucleic acid metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 6.56e-06 3058 10 10 1.000 0.003 GO:0010467 BP 1 gene expression 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 8.14e-06 2136 10 9 0.900 0.004 GO:0003676 MF 1 nucleic acid binding 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 9.34e-06 3168 10 10 1.000 0.003 GO:0044428 CC 1 nuclear part 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.64e-05 564 10 6 0.600 0.011 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.15e-05 3443 10 10 1.000 0.003 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.61e-05 5 10 2 0.200 0.400 GO:0030621 MF 1 U4 snRNA binding 1 Q8WWY3,O43172 430 2.70e-05 46 10 3 0.300 0.065 GO:0000245 BP 1 spliceosomal complex assembly 1 O94906,Q53GS9,Q9BUQ8 430 2.73e-05 1113 10 7 0.700 0.006 GO:0065003 BP 1 macromolecular complex assembly 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 2.81e-05 1118 10 7 0.700 0.006 GO:0044822 MF 1 poly(A) RNA binding 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,Q9BUQ8,O43290 430 2.95e-05 3554 10 10 1.000 0.003 GO:0046483 BP 1 heterocycle metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.01e-05 3561 10 10 1.000 0.003 GO:0070013 CC 1 intracellular organelle lumen 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.01e-05 3561 10 10 1.000 0.003 GO:0043233 CC 1 organelle lumen 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.01e-05 3561 10 10 1.000 0.003 GO:0031974 CC 1 membrane-enclosed lumen 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.01e-05 3561 10 10 1.000 0.003 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.20e-05 3681 10 10 1.000 0.003 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.77e-05 2612 10 9 0.900 0.003 GO:1901363 MF 1 heterocyclic compound binding 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 5.59e-05 2660 10 9 0.900 0.003 GO:0097159 MF 1 organic cyclic compound binding 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 5.88e-05 48 10 4 0.400 0.083 HP:0007987 hp 1 Progressive visual field defects 1 O94906,Q8WWY3,O43395,O43172 430 5.88e-05 48 10 4 0.400 0.083 HP:0008028 hp 1 Cystoid macular degeneration 1 O94906,Q8WWY3,O43395,O43172 430 5.88e-05 48 10 4 0.400 0.083 HP:0200070 hp 1 Peripheral retinal atrophy 1 O94906,Q8WWY3,O43395,O43172 430 5.88e-05 48 10 4 0.400 0.083 HP:0007830 hp 1 Adult-onset night blindness 1 O94906,Q8WWY3,O43395,O43172 430 6.39e-05 49 10 4 0.400 0.082 HP:0007950 hp 1 Peripapillary chorioretinal atrophy 1 O94906,Q8WWY3,O43395,O43172 430 6.93e-05 50 10 4 0.400 0.080 HP:0011519 hp 1 Anomalous trichromacy 1 O94906,Q8WWY3,O43395,O43172 430 6.93e-05 50 10 4 0.400 0.080 HP:0000552 hp 1 Tritanomaly 1 O94906,Q8WWY3,O43395,O43172 430 6.93e-05 50 10 4 0.400 0.080 HP:0011505 hp 1 Cystoid macular edema 1 O94906,Q8WWY3,O43395,O43172 430 7.51e-05 51 10 4 0.400 0.078 HP:0000642 hp 1 Red-green dyschromatopsia 1 O94906,Q8WWY3,O43395,O43172 430 7.51e-05 51 10 4 0.400 0.078 HP:0007722 hp 1 Retinal pigment epithelial atrophy 1 O94906,Q8WWY3,O43395,O43172 430 7.51e-05 51 10 4 0.400 0.078 HP:0040049 hp 1 Macular edema 1 O94906,Q8WWY3,O43395,O43172 430 7.52e-05 733 10 6 0.600 0.008 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 7.70e-05 65 10 3 0.300 0.046 GO:0043021 MF 1 ribonucleoprotein complex binding 1 O94906,O60828,Q8WWY3 430 8.12e-05 52 10 4 0.400 0.077 HP:0008020 hp 1 Progressive cone degeneration 1 O94906,Q8WWY3,O43395,O43172 430 8.12e-05 52 10 4 0.400 0.077 HP:0030498 hp 1 Macular thickening 1 O94906,Q8WWY3,O43395,O43172 430 8.46e-05 3948 10 10 1.000 0.003 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 8.77e-05 53 10 4 0.400 0.075 HP:0001146 hp 1 Pigmentary retinal degeneration 1 O94906,Q8WWY3,O43395,O43172 430 9.27e-05 1804 10 8 0.800 0.004 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8,O43290 430 9.45e-05 54 10 4 0.400 0.074 HP:0007737 hp 1 Bone spicule pigmentation of the retina 1 O94906,Q8WWY3,O43395,O43172 430 1.09e-04 56 10 4 0.400 0.071 HP:0001099 hp 1 Fundus atrophy 1 O94906,Q8WWY3,O43395,O43172 430 1.26e-04 58 10 4 0.400 0.069 HP:0002527 hp 1 Falls 1 O94906,Q8WWY3,O43395,O43172 430 1.26e-04 58 10 4 0.400 0.069 HP:0007787 hp 1 Posterior subcapsular cataract 1 O94906,Q8WWY3,O43395,O43172 430 1.35e-04 59 10 4 0.400 0.068 HP:0000622 hp 1 Blurred vision 1 O94906,Q8WWY3,O43395,O43172 430 1.35e-04 59 10 4 0.400 0.068 HP:0007641 hp 1 Dyschromatopsia 1 O94906,Q8WWY3,O43395,O43172 430 1.44e-04 80 10 3 0.300 0.037 GO:0016607 CC 1 nuclear speck 1 O60828,Q8WWY3,O43172 430 1.44e-04 60 10 4 0.400 0.067 HP:0007994 hp 1 Peripheral visual field loss 1 O94906,Q8WWY3,O43395,O43172 430 1.44e-04 60 10 4 0.400 0.067 HP:0007894 hp 1 Hypopigmentation of the fundus 1 O94906,Q8WWY3,O43395,O43172 430 1.44e-04 60 10 4 0.400 0.067 HP:0008043 hp 1 Retinal arteriolar constriction 1 O94906,Q8WWY3,O43395,O43172 430 1.44e-04 60 10 4 0.400 0.067 HP:0001115 hp 1 Posterior polar cataract 1 O94906,Q8WWY3,O43395,O43172 430 1.49e-04 521 10 5 0.500 0.010 GO:0044451 CC 1 nucleoplasm part 1 O60828,Q8WWY3,O43395,O43172,O43290 430 1.65e-04 129 10 5 0.500 0.039 HP:0001696 hp 1 Situs inversus totalis 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.65e-04 129 10 5 0.500 0.039 HP:0011534 hp 1 Abnormal spatial orientation of the cardiac segments 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.71e-04 1485 10 10 1.000 0.007 REAC:74160 rea 1 Gene Expression 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.75e-04 63 10 4 0.400 0.063 HP:0012045 hp 1 Retinal flecks 1 O94906,Q8WWY3,O43395,O43172 430 1.83e-04 4264 10 10 1.000 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.87e-04 64 10 4 0.400 0.062 HP:0001105 hp 1 Retinal atrophy 1 O94906,Q8WWY3,O43395,O43172 430 1.98e-04 65 10 4 0.400 0.062 HP:0000523 hp 1 Subcapsular cataract 1 O94906,Q8WWY3,O43395,O43172 430 2.06e-04 135 10 5 0.500 0.037 HP:0001651 hp 1 Dextrocardia 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.11e-04 66 10 4 0.400 0.061 HP:0000603 hp 1 Central scotoma 1 O94906,Q8WWY3,O43395,O43172 430 2.11e-04 66 10 4 0.400 0.061 HP:0007688 hp 1 Undetectable light- and dark-adapted electroretinogram 1 O94906,Q8WWY3,O43395,O43172 430 2.11e-04 66 10 4 0.400 0.061 HP:0007843 hp 1 Attenuation of retinal blood vessels 1 O94906,Q8WWY3,O43395,O43172 430 2.14e-04 136 10 5 0.500 0.037 HP:0004307 hp 1 Abnormal anatomic location of the heart 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.24e-04 67 10 4 0.400 0.060 HP:0000842 hp 1 Hyperinsulinemia 1 O94906,Q8WWY3,O43395,O43172 430 2.24e-04 67 10 4 0.400 0.060 HP:0040214 hp 1 Abnormal insulin level 1 O94906,Q8WWY3,O43395,O43172 430 2.24e-04 67 10 4 0.400 0.060 HP:0040215 hp 1 Abnormal circulating insulin level 1 O94906,Q8WWY3,O43395,O43172 430 2.54e-04 906 10 6 0.600 0.007 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.66e-04 70 10 4 0.400 0.057 HP:0007875 hp 1 Congenital blindness 1 O94906,Q8WWY3,O43395,O43172 430 2.66e-04 70 10 4 0.400 0.057 HP:0000533 hp 1 Chorioretinal atrophy 1 O94906,Q8WWY3,O43395,O43172 430 2.68e-04 4430 10 10 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.82e-04 71 10 4 0.400 0.056 HP:0200065 hp 1 Chorioretinal degeneration 1 O94906,Q8WWY3,O43395,O43172 430 2.98e-04 72 10 4 0.400 0.056 HP:0001133 hp 1 Constriction of peripheral visual field 1 O94906,Q8WWY3,O43395,O43172 430 3.10e-04 938 10 6 0.600 0.006 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.14e-04 73 10 4 0.400 0.055 HP:0012263 hp 1 Immotile cilia 1 O94906,Q8WWY3,O43395,O43172 430 3.14e-04 73 10 4 0.400 0.055 HP:0030506 hp 1 Yellow/white lesions of the retina 1 O94906,Q8WWY3,O43395,O43172 430 3.19e-04 943 10 6 0.600 0.006 HPA:035040_03 hpa 1 skin 1; melanocytes[Uncertain,High] 1 Q9Y2W2,O94906,O60828,Q8WWY3,Q9BUQ8,O43290 430 3.26e-04 1614 10 7 0.700 0.004 GO:0043933 BP 1 macromolecular complex subunit organization 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 3.32e-04 74 10 4 0.400 0.054 HP:0012261 hp 1 Abnormal respiratory motile cilium physiology 1 O94906,Q8WWY3,O43395,O43172 430 3.32e-04 74 10 4 0.400 0.054 HP:0012043 hp 1 Pendular nystagmus 1 O94906,Q8WWY3,O43395,O43172 430 3.32e-04 74 10 4 0.400 0.054 HP:0012262 hp 1 Abnormal ciliary motility 1 O94906,Q8WWY3,O43395,O43172 430 3.44e-04 150 10 5 0.500 0.033 HP:0000540 hp 1 Hypermetropia 1 O94906,O60828,Q8WWY3,O43395,O43172 430 3.50e-04 75 10 4 0.400 0.053 HP:0100692 hp 1 Increased corneal curvature 1 O94906,Q8WWY3,O43395,O43172 430 3.50e-04 75 10 4 0.400 0.053 HP:0000563 hp 1 Keratoconus 1 O94906,Q8WWY3,O43395,O43172 430 3.50e-04 75 10 4 0.400 0.053 HP:0001141 hp 1 Severe visual impairment 1 O94906,Q8WWY3,O43395,O43172 430 3.88e-04 77 10 4 0.400 0.052 HP:0000575 hp 1 Scotoma 1 O94906,Q8WWY3,O43395,O43172 430 3.88e-04 77 10 4 0.400 0.052 HP:0007401 hp 1 Macular atrophy 1 O94906,Q8WWY3,O43395,O43172 430 3.88e-04 77 10 4 0.400 0.052 HP:0100689 hp 1 Decreased corneal thickness 1 O94906,Q8WWY3,O43395,O43172 430 3.94e-04 1508 10 7 0.700 0.005 HPA:036010_03 hpa 1 skin 2; epidermal cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 4.29e-04 79 10 4 0.400 0.051 HP:0011486 hp 1 Abnormality of corneal thickness 1 O94906,Q8WWY3,O43395,O43172 430 4.70e-04 1706 10 7 0.700 0.004 GO:0022607 BP 1 cellular component assembly 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 4.74e-04 81 10 4 0.400 0.049 HP:0000654 hp 1 Decreased light- and dark-adapted electroretinogram amplitude 1 O94906,Q8WWY3,O43395,O43172 430 4.76e-04 596 10 5 0.500 0.008 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 5.12e-04 1025 10 6 0.600 0.006 HPA:008020_03 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 5.21e-04 83 10 4 0.400 0.048 HP:0000630 hp 1 Abnormality of retinal arteries 1 O94906,Q8WWY3,O43395,O43172 430 5.21e-04 83 10 4 0.400 0.048 HP:0010696 hp 1 Polar cataract 1 O94906,Q8WWY3,O43395,O43172 430 5.72e-04 85 10 4 0.400 0.047 HP:3000036 hp 1 Abnormality of head blood vessel 1 O94906,Q8WWY3,O43395,O43172 430 5.99e-04 86 10 4 0.400 0.047 HP:0000548 hp 1 Cone/cone-rod dystrophy 1 O94906,Q8WWY3,O43395,O43172 430 6.39e-04 634 10 5 0.500 0.008 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 6.55e-04 88 10 4 0.400 0.045 HP:0005978 hp 1 Type II diabetes mellitus 1 O94906,Q8WWY3,O43395,O43172 430 7.15e-04 90 10 4 0.400 0.044 HP:0008323 hp 1 Abnormal light- and dark-adapted electroretinogram 1 O94906,Q8WWY3,O43395,O43172 430 7.47e-04 91 10 4 0.400 0.044 HP:0000987 hp 1 Atypical scarring of skin 1 O94906,Q8WWY3,O43395,O43172 430 7.76e-04 25 10 2 0.200 0.080 GO:0071011 CC 1 precatalytic spliceosome 1 Q96DI7,Q8WWY3 430 7.79e-04 92 10 4 0.400 0.043 HP:0000529 hp 1 Progressive visual loss 1 O94906,Q8WWY3,O43395,O43172 430 7.79e-04 92 10 4 0.400 0.043 HP:0030466 hp 1 Abnormal full-field electroretinogram 1 O94906,Q8WWY3,O43395,O43172 430 8.13e-04 93 10 4 0.400 0.043 HP:0000551 hp 1 Abnormality of color vision 1 O94906,Q8WWY3,O43395,O43172 430 8.13e-04 93 10 4 0.400 0.043 HP:0030637 hp 1 Cone dysfunction 1 O94906,Q8WWY3,O43395,O43172 430 8.36e-04 56 10 2 0.200 0.036 TF:M03951_0 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 0 1 Q96DI7,Q8WWY3 430 8.73e-04 345 10 4 0.400 0.012 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 O94906,O60828,Q8WWY3,O43172 430 8.83e-04 4990 10 10 1.000 0.002 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 9.30e-04 131 10 3 0.300 0.023 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 O94906,O60828,Q8WWY3 430 9.39e-04 185 10 5 0.500 0.027 HP:0000618 hp 1 Blindness 1 O94906,O60828,Q8WWY3,O43395,O43172 430 9.58e-04 97 10 4 0.400 0.041 HP:0000550 hp 1 Undetectable electroretinogram 1 O94906,Q8WWY3,O43395,O43172 430 9.59e-04 2454 10 8 0.800 0.003 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8,O43290 430 9.97e-04 98 10 4 0.400 0.041 HP:0000608 hp 1 Macular degeneration 1 O94906,Q8WWY3,O43395,O43172 430 1.06e-03 1932 10 7 0.700 0.004 GO:0044085 BP 1 cellular component biogenesis 1 O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 1.19e-03 2527 10 8 0.800 0.003 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8,O43290 430 1.20e-03 31 10 2 0.200 0.065 GO:0017069 MF 1 snRNA binding 1 Q8WWY3,O43172 430 1.25e-03 730 10 5 0.500 0.007 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 1.36e-03 200 10 5 0.500 0.025 HP:0000819 hp 1 Diabetes mellitus 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.41e-03 391 10 4 0.400 0.010 HPA:035040_13 hpa 1 skin 1; melanocytes[Supportive,High] 1 O94906,O60828,Q8WWY3,O43290 430 1.45e-03 108 10 4 0.400 0.037 HP:0100699 hp 1 Scarring 1 O94906,Q8WWY3,O43395,O43172 430 1.50e-03 1241 10 6 0.600 0.005 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 1.60e-03 1256 10 6 0.600 0.005 HPA:025010_03 hpa 1 oral mucosa; squamous epithelial cells[Uncertain,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.67e-03 5319 10 10 1.000 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.68e-03 160 10 3 0.300 0.019 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 O60828,Q8WWY3,O43172 430 1.85e-03 115 10 4 0.400 0.035 HP:0001123 hp 1 Visual field defect 1 O94906,Q8WWY3,O43395,O43172 430 1.94e-03 802 10 5 0.500 0.006 HPA:035010_03 hpa 1 skin 1; Langerhans[Uncertain,High] 1 O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 1.98e-03 117 10 4 0.400 0.034 HP:0000980 hp 1 Pallor 1 O94906,Q8WWY3,O43395,O43172 430 2.36e-03 225 10 5 0.500 0.022 HP:0001419 hp 1 X-linked recessive inheritance 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.39e-03 123 10 4 0.400 0.033 HP:0000541 hp 1 Retinal detachment 1 O94906,Q8WWY3,O43395,O43172 430 2.50e-03 454 10 4 0.400 0.009 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 2.62e-03 126 10 4 0.400 0.032 HP:0000613 hp 1 Photophobia 1 O94906,Q8WWY3,O43395,O43172 430 2.88e-03 1396 10 6 0.600 0.004 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.90e-03 874 10 5 0.500 0.006 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 2.96e-03 130 10 4 0.400 0.031 HP:0000483 hp 1 Astigmatism 1 O94906,Q8WWY3,O43395,O43172 430 2.96e-03 130 10 4 0.400 0.031 HP:0008046 hp 1 Abnormality of the retinal vasculature 1 O94906,Q8WWY3,O43395,O43172 430 3.04e-03 131 10 4 0.400 0.031 HP:0000543 hp 1 Optic disc pallor 1 O94906,Q8WWY3,O43395,O43172 430 3.24e-03 486 10 4 0.400 0.008 HPA:023010_13 hpa 1 lymph node; germinal center cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 3.32e-03 489 10 4 0.400 0.008 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 3.35e-03 1 10 1 0.100 1.000 GO:0070990 MF 1 snRNP binding 1 Q8WWY3 430 3.35e-03 1 10 1 0.100 1.000 GO:0000481 BP 1 maturation of 5S rRNA 1 O43290 430 3.35e-03 1 10 1 0.100 1.000 GO:0005690 CC 1 U4atac snRNP 1 Q8WWY3 430 3.36e-03 902 10 5 0.500 0.006 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 3.42e-03 1440 10 6 0.600 0.004 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 3.60e-03 5578 10 9 0.900 0.002 TF:M00801_0 tf 1 Factor: CREB; motif: CGTCAN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.75e-03 505 10 4 0.400 0.008 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 3.79e-03 1033 10 5 0.500 0.005 GO:1902494 CC 1 catalytic complex 1 Q96DI7,O94906,Q8WWY3,Q9BUQ8,O43290 430 3.81e-03 139 10 4 0.400 0.029 HP:0008047 hp 1 Abnormality of the vasculature of the eye 1 O94906,Q8WWY3,O43395,O43172 430 3.83e-03 1470 10 6 0.600 0.004 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.87e-03 930 10 5 0.500 0.005 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 3.89e-03 5787 10 10 1.000 0.002 GO:0044446 CC 1 intracellular organelle part 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.26e-03 1499 10 6 0.600 0.004 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.31e-03 221 10 3 0.300 0.014 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 O60828,Q8WWY3,O43172 430 4.44e-03 958 10 5 0.500 0.005 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.49e-03 1513 10 6 0.600 0.004 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.54e-03 5877 10 10 1.000 0.002 GO:0044422 CC 1 organelle part 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.59e-03 965 10 5 0.500 0.005 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172,O43290 430 4.62e-03 1521 10 6 0.600 0.004 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.71e-03 147 10 4 0.400 0.027 HP:0003829 hp 1 Incomplete penetrance 1 O94906,Q8WWY3,O43395,O43172 430 4.72e-03 537 10 4 0.400 0.007 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 4.86e-03 541 10 4 0.400 0.007 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 5.13e-03 549 10 4 0.400 0.007 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 O60828,Q8WWY3,O43172,Q9BUQ8 430 5.22e-03 267 10 5 0.500 0.019 HP:0000431 hp 1 Wide nasal bridge 1 O94906,O60828,Q8WWY3,O43395,O43172 430 5.28e-03 995 10 5 0.500 0.005 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 O94906,O60828,Q8WWY3,O43172,O43290 430 5.45e-03 1002 10 5 0.500 0.005 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 5.49e-03 7 10 1 0.100 0.143 TF:M05874_1 tf 1 Factor: ZNF564; motif: KGGWHGTGAACM; match class: 1 1 O43290 430 5.56e-03 3415 10 8 0.800 0.002 GO:0032991 CC 1 macromolecular complex 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 5.60e-03 1576 10 6 0.600 0.004 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 5.68e-03 564 10 4 0.400 0.007 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 6.03e-03 157 10 4 0.400 0.025 HP:0001103 hp 1 Abnormality of the macula 1 O94906,Q8WWY3,O43395,O43172 430 6.06e-03 1599 10 6 0.600 0.004 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 6.08e-03 4605 10 8 0.800 0.002 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 6.27e-03 8 10 1 0.100 0.125 TF:M06067_0 tf 1 Factor: ZNF195; motif: NAWTCCWAAAGM; match class: 0 1 Q9BUQ8 430 6.47e-03 160 10 4 0.400 0.025 HP:0100691 hp 1 Abnormality of the curvature of the cornea 1 O94906,Q8WWY3,O43395,O43172 430 6.70e-03 2 10 1 0.100 0.500 GO:0045583 BP 1 regulation of cytotoxic T cell differentiation 1 O43290 430 6.70e-03 2 10 1 0.100 0.500 GO:0045585 BP 1 positive regulation of cytotoxic T cell differentiation 1 O43290 430 6.70e-03 2 10 1 0.100 0.500 GO:0045065 BP 1 cytotoxic T cell differentiation 1 O43290 430 6.70e-03 2 10 1 0.100 0.500 GO:0030622 MF 1 U4atac snRNA binding 1 Q8WWY3 430 6.70e-03 2 10 1 0.100 0.500 GO:0000354 BP 1 cis assembly of pre-catalytic spliceosome 1 Q9BUQ8 430 6.72e-03 4237 10 9 0.900 0.002 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 6.90e-03 6128 10 10 1.000 0.002 GO:0044238 BP 1 primary metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 6.91e-03 1055 10 5 0.500 0.005 HPA:006030_03 hpa 1 cerebellum; cells in molecular layer[Uncertain,High] 1 Q96DI7,O60828,Q8WWY3,O43172,Q9BUQ8 430 7.27e-03 168 10 2 0.200 0.012 TF:M00804_1 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 1 1 O94906,Q9BUQ8 430 7.40e-03 1659 10 6 0.600 0.004 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 7.62e-03 1078 10 5 0.500 0.005 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 7.67e-03 1670 10 6 0.600 0.004 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 7.70e-03 270 10 3 0.300 0.011 HPA:040040_03 hpa 1 soft tissue 2; peripheral nerve[Uncertain,High] 1 O94906,O60828,Q8WWY3 430 7.76e-03 168 10 4 0.400 0.024 HP:0000662 hp 1 Nyctalopia 1 O94906,Q8WWY3,O43395,O43172 430 7.76e-03 168 10 4 0.400 0.024 HP:0003117 hp 1 Abnormality of circulating hormone level 1 O94906,Q8WWY3,O43395,O43172 430 7.76e-03 168 10 4 0.400 0.024 HP:0000532 hp 1 Chorioretinal abnormality 1 O94906,Q8WWY3,O43395,O43172 430 7.83e-03 10 10 1 0.100 0.100 TF:M06049_1 tf 1 Factor: ZNF208; motif: NGNGGGAGTTCM; match class: 1 1 O94906 430 7.94e-03 169 10 4 0.400 0.024 HP:0100259 hp 1 Postaxial polydactyly 1 O94906,Q8WWY3,O43395,O43172 430 8.05e-03 1091 10 5 0.500 0.005 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 8.11e-03 170 10 4 0.400 0.024 HP:0000546 hp 1 Retinal degeneration 1 O94906,Q8WWY3,O43395,O43172 430 8.29e-03 171 10 4 0.400 0.023 HP:0000572 hp 1 Visual loss 1 O94906,Q8WWY3,O43395,O43172 430 8.64e-03 631 10 4 0.400 0.006 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 8.66e-03 173 10 4 0.400 0.023 HP:0007663 hp 1 Reduced visual acuity 1 O94906,Q8WWY3,O43395,O43172 430 8.67e-03 184 10 2 0.200 0.011 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 Q53GS9,Q9BUQ8 430 8.67e-03 184 10 2 0.200 0.011 TF:M00998_1 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 1 1 Q96DI7,Q8WWY3 430 8.85e-03 174 10 4 0.400 0.023 HP:0000512 hp 1 Abnormal electroretinogram 1 O94906,Q8WWY3,O43395,O43172 430 9.05e-03 639 10 4 0.400 0.006 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3 430 9.09e-03 6299 10 10 1.000 0.002 GO:0044237 BP 1 cellular metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 9.10e-03 585 10 3 0.300 0.005 TF:M02085_1 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 1 1 Q9Y2W2,O43395,Q9BUQ8 430 9.39e-03 12 10 1 0.100 0.083 TF:M06228_0 tf 1 Factor: ZNF543; motif: KGGWATRTGGGA; match class: 0 1 O43290 430 9.41e-03 1129 10 5 0.500 0.004 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 9.56e-03 1133 10 5 0.500 0.004 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 9.62e-03 178 10 4 0.400 0.022 HP:0000597 hp 1 Ophthalmoparesis 1 O94906,Q8WWY3,O43395,O43172 430 9.64e-03 1135 10 5 0.500 0.004 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 9.64e-03 650 10 4 0.400 0.006 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 9.82e-03 179 10 4 0.400 0.022 HP:0000610 hp 1 Abnormality of the choroid 1 O94906,Q8WWY3,O43395,O43172 430 9.88e-03 197 10 2 0.200 0.010 TF:M05408_0 tf 1 Factor: ZNF438; motif: NAMGAKCGKATTGK; match class: 0 1 O60828,O43290 430 1.00e-02 1188 10 4 0.400 0.003 TF:M01968_1 tf 1 Factor: FOXO1; motif: TGTTKAC; match class: 1 1 Q9Y2W2,O60828,O43172,Q53GS9 430 1.00e-02 3 10 1 0.100 0.333 GO:0071001 CC 1 U4/U6 snRNP 1 O43172 430 1.04e-02 8065 10 10 1.000 0.001 TF:M00032_0 tf 1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.10e-02 674 10 4 0.400 0.006 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 Q96DI7,O94906,Q8WWY3,O43172 430 1.10e-02 1787 10 6 0.600 0.003 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.13e-02 1175 10 5 0.500 0.004 HPA:048010_03 hpa 1 vagina; squamous epithelial cells[Uncertain,High] 1 Q96DI7,O60828,Q8WWY3,O43172,Q9BUQ8 430 1.15e-02 682 10 4 0.400 0.006 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 O60828,Q8WWY3,O43172,Q9BUQ8 430 1.15e-02 187 10 4 0.400 0.021 HP:0000510 hp 1 Rod-cone dystrophy 1 O94906,Q8WWY3,O43395,O43172 430 1.21e-02 1818 10 6 0.600 0.003 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.21e-02 6484 10 10 1.000 0.002 GO:0071704 BP 1 organic substance metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.22e-02 317 10 3 0.300 0.009 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 O94906,O60828,Q8WWY3 430 1.22e-02 322 10 5 0.500 0.016 HP:0000050 hp 1 Hypoplastic male external genitalia 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.24e-02 1825 10 6 0.600 0.003 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.25e-02 16 10 1 0.100 0.062 TF:M06270_0 tf 1 Factor: ZNF468; motif: KGGGGGWGCGGA; match class: 0 1 O43395 430 1.25e-02 1830 10 6 0.600 0.003 HPA:012010_02 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 1.33e-02 17 10 1 0.100 0.059 TF:M06386_0 tf 1 Factor: ZNF836; motif: NGGTGAAGCCAG; match class: 0 1 O94906 430 1.36e-02 329 10 3 0.300 0.009 HPA:012010_03 hpa 1 endometrium 2; cells in endometrial stroma[Uncertain,High] 1 O60828,Q8WWY3,Q9BUQ8 430 1.36e-02 1857 10 6 0.600 0.003 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.38e-02 1230 10 5 0.500 0.004 HPA:041010_12 hpa 1 spleen; cells in red pulp[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 1.40e-02 3882 10 8 0.800 0.002 GO:0016043 BP 1 cellular component organization 1 Q9Y2W2,O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 1.47e-02 1885 10 6 0.600 0.003 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.47e-02 1247 10 5 0.500 0.004 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 1.48e-02 336 10 5 0.500 0.015 HP:0003241 hp 1 External genital hypoplasia 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.50e-02 4659 10 9 0.900 0.002 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 1.50e-02 341 10 3 0.300 0.009 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 O60828,Q8WWY3,O43172 430 1.51e-02 3018 10 6 0.600 0.002 TF:M01863_0 tf 1 Factor: ATF-3; motif: RTKRCGTCANN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O43395,O43172,Q9BUQ8 430 1.54e-02 6642 10 10 1.000 0.002 GO:0008152 BP 1 metabolic process 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.59e-02 204 10 4 0.400 0.020 HP:0030453 hp 1 Abnormal visual electrophysiology 1 O94906,Q8WWY3,O43395,O43172 430 1.61e-02 6671 10 10 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 1.62e-02 1274 10 5 0.500 0.004 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 1.64e-02 1924 10 6 0.600 0.003 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.67e-02 5 10 1 0.100 0.200 GO:0048254 BP 1 snoRNA localization 1 Q8WWY3 430 1.67e-02 755 10 4 0.400 0.005 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 1.68e-02 346 10 5 0.500 0.014 HP:0011014 hp 1 Abnormal glucose homeostasis 1 O94906,O60828,Q8WWY3,O43395,O43172 430 1.71e-02 2174 10 5 0.500 0.002 TF:M04303_0 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 0 1 Q96DI7,Q8WWY3,O43395,O43172,Q9BUQ8 430 1.71e-02 3093 10 6 0.600 0.002 TF:M00916_0 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 0 1 Q96DI7,Q9Y2W2,O94906,Q8WWY3,O43395,O43172 430 1.78e-02 4013 10 8 0.800 0.002 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q9Y2W2,O94906,O60828,Q8WWY3,O43395,Q53GS9,Q9BUQ8,O43290 430 1.79e-02 5379 10 8 0.800 0.001 TF:M02071_1 tf 1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 1 Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 1.83e-02 212 10 4 0.400 0.019 HP:0000501 hp 1 Glaucoma 1 O94906,Q8WWY3,O43395,O43172 430 1.86e-02 213 10 4 0.400 0.019 HP:0000405 hp 1 Conductive hearing impairment 1 O94906,Q8WWY3,O43395,O43172 430 1.87e-02 5415 10 8 0.800 0.001 TF:M07313_0 tf 1 Factor: ATF-3; motif: SNTGACGYNATN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9 430 1.88e-02 1974 10 6 0.600 0.003 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.89e-02 781 10 4 0.400 0.005 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 1.92e-02 215 10 4 0.400 0.019 HP:0001513 hp 1 Obesity 1 O94906,Q8WWY3,O43395,O43172 430 1.94e-02 786 10 4 0.400 0.005 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 Q9Y2W2,O60828,Q8WWY3,Q9BUQ8 430 1.96e-02 1990 10 6 0.600 0.003 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 1.98e-02 359 10 5 0.500 0.014 HP:0000553 hp 1 Abnormality of the uvea 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.00e-02 1998 10 6 0.600 0.003 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.08e-02 291 10 2 0.200 0.007 TF:M01801_1 tf 1 Factor: ER-alpha; motif: AGGTCACNGTGACCT; match class: 1 1 Q96DI7,O94906 430 2.08e-02 291 10 2 0.200 0.007 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 O43172,Q9BUQ8 430 2.10e-02 384 10 3 0.300 0.008 HPA:040010_03 hpa 1 soft tissue 2; adipocytes[Uncertain,High] 1 O60828,Q8WWY3,O43172 430 2.11e-02 804 10 4 0.400 0.005 HPA:019010_03 hpa 1 kidney; cells in glomeruli[Uncertain,High] 1 Q9Y2W2,O60828,Q8WWY3,Q9BUQ8 430 2.18e-02 28 10 1 0.100 0.036 TF:M06299_0 tf 1 Factor: ZNF672; motif: KGKTGCYGGGGW; match class: 0 1 Q53GS9 430 2.19e-02 223 10 4 0.400 0.018 HP:0004324 hp 1 Increased body weight 1 O94906,Q8WWY3,O43395,O43172 430 2.21e-02 301 10 2 0.200 0.007 TF:M06188_0 tf 1 Factor: ZNF135; motif: NGTGGCTAMCGC; match class: 0 1 O60828,O43395 430 2.28e-02 2049 10 6 0.600 0.003 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.29e-02 2051 10 6 0.600 0.003 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.42e-02 2072 10 6 0.600 0.003 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.42e-02 404 10 3 0.300 0.007 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 O60828,Q8WWY3,O43172 430 2.43e-02 836 10 4 0.400 0.005 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 2.43e-02 1396 10 5 0.500 0.004 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 2.43e-02 2367 10 5 0.500 0.002 TF:M00981_1 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 1 1 Q96DI7,Q9Y2W2,O94906,O43395,O43172 430 2.49e-02 408 10 3 0.300 0.007 HPA:006020_13 hpa 1 cerebellum; cells in granular layer[Supportive,High] 1 O60828,Q8WWY3,O43172 430 2.51e-02 2086 10 6 0.600 0.003 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.53e-02 1408 10 5 0.500 0.004 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 Q96DI7,O60828,Q8WWY3,O43172,Q9BUQ8 430 2.53e-02 1408 10 5 0.500 0.004 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 2.57e-02 381 10 5 0.500 0.013 HP:0000539 hp 1 Abnormality of refraction 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.61e-02 2102 10 6 0.600 0.003 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.62e-02 1419 10 5 0.500 0.004 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 2.63e-02 416 10 3 0.300 0.007 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 Q96DI7,O60828,Q8WWY3 430 2.64e-02 7114 10 9 0.900 0.001 TF:M02114_1 tf 1 Factor: pitx2; motif: NNTAAWCCCA; match class: 1 1 Q96DI7,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.64e-02 7114 10 9 0.900 0.001 TF:M07056_1 tf 1 Factor: Pitx2; motif: WNTAAWCCCA; match class: 1 1 Q96DI7,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.66e-02 384 10 5 0.500 0.013 HP:0001417 hp 1 X-linked inheritance 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.72e-02 2119 10 6 0.600 0.003 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.77e-02 867 10 4 0.400 0.005 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 O94906,O60828,Q8WWY3,Q9BUQ8 430 2.79e-02 388 10 5 0.500 0.013 HP:0010985 hp 1 Gonosomal inheritance 1 O94906,O60828,Q8WWY3,O43395,O43172 430 2.79e-02 2130 10 6 0.600 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.81e-02 871 10 4 0.400 0.005 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 2.81e-02 239 10 4 0.400 0.017 HP:0010442 hp 1 Polydactyly 1 O94906,Q8WWY3,O43395,O43172 430 2.85e-02 2459 10 5 0.500 0.002 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 Q96DI7,O94906,Q8WWY3,O43395,Q9BUQ8 430 2.86e-02 2139 10 6 0.600 0.003 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.88e-02 877 10 4 0.400 0.005 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 2.89e-02 347 10 2 0.200 0.006 TF:M06902_0 tf 1 Factor: ZNF611; motif: NTTAKAAAAANC; match class: 0 1 Q9Y2W2,Q9BUQ8 430 2.90e-02 1453 10 5 0.500 0.003 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 2.91e-02 879 10 4 0.400 0.005 HPA:035030_03 hpa 1 skin 1; keratinocytes[Uncertain,High] 1 O60828,Q8WWY3,O43172,Q9BUQ8 430 2.94e-02 8946 10 10 1.000 0.001 TF:M07061_1 tf 1 Factor: POU4F3; motif: CTAATYW; match class: 1 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 2.95e-02 2153 10 6 0.600 0.003 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 2.96e-02 2154 10 6 0.600 0.003 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.00e-02 2159 10 6 0.600 0.003 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.01e-02 9 10 1 0.100 0.111 GO:0034063 BP 1 stress granule assembly 1 O60828 430 3.02e-02 158 10 2 0.200 0.013 GO:0006403 BP 1 RNA localization 1 O94906,Q8WWY3 430 3.03e-02 244 10 4 0.400 0.016 HP:0000556 hp 1 Retinal dystrophy 1 O94906,Q8WWY3,O43395,O43172 430 3.04e-02 2165 10 6 0.600 0.003 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 3.10e-02 2173 10 6 0.600 0.003 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 3.11e-02 398 10 5 0.500 0.013 HP:0011013 hp 1 Abnormality of carbohydrate metabolism/homeostasis 1 O94906,O60828,Q8WWY3,O43395,O43172 430 3.13e-02 2177 10 6 0.600 0.003 HPA:047010_03 hpa 1 urinary bladder; urothelial cells[Uncertain,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 3.15e-02 364 10 2 0.200 0.005 TF:M04330_0 tf 1 Factor: HESX1; motif: NNTAATTRNN; match class: 0 1 O94906,Q53GS9 430 3.21e-02 248 10 4 0.400 0.016 HP:0011452 hp 1 Functional abnormality of the middle ear 1 O94906,Q8WWY3,O43395,O43172 430 3.21e-02 2188 10 6 0.600 0.003 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.22e-02 368 10 2 0.200 0.005 TF:M05704_0 tf 1 Factor: ZNF133; motif: NGGTTAAACNSM; match class: 0 1 O43395,Q53GS9 430 3.26e-02 1492 10 5 0.500 0.003 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 3.28e-02 909 10 4 0.400 0.004 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 O60828,Q8WWY3,O43172,Q9BUQ8 430 3.28e-02 2197 10 6 0.600 0.003 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.30e-02 9050 10 10 1.000 0.001 TF:M04191_0 tf 1 Factor: TCF4; motif: NNCACCTGNN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.32e-02 2202 10 6 0.600 0.003 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.33e-02 913 10 4 0.400 0.004 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 Q96DI7,O94906,Q8WWY3,O43172 430 3.34e-02 10 10 1 0.100 0.100 GO:0017070 MF 1 U6 snRNA binding 1 O43172 430 3.34e-02 10 10 1 0.100 0.100 GO:0005687 CC 1 U4 snRNP 1 Q8WWY3 430 3.37e-02 2209 10 6 0.600 0.003 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.41e-02 919 10 4 0.400 0.004 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 3.42e-02 2215 10 6 0.600 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.44e-02 921 10 4 0.400 0.004 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 3.46e-02 1706 10 4 0.400 0.002 TF:M07034_1 tf 1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 1 Q96DI7,O94906,O43395,O43172 430 3.48e-02 1709 10 4 0.400 0.002 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q96DI7,O94906,O43395,Q9BUQ8 430 3.51e-02 4019 10 8 0.800 0.002 HPA:008020_02 hpa 1 cervix, uterine; squamous epithelial cells[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8,O43290 430 3.52e-02 2227 10 6 0.600 0.003 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.52e-02 2227 10 6 0.600 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.56e-02 3061 10 7 0.700 0.002 HPA:031010_03 hpa 1 rectum; glandular cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 3.59e-02 9128 10 10 1.000 0.001 TF:M03541_1 tf 1 Factor: C-Jun; motif: TGACTC; match class: 1 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 3.62e-02 392 10 2 0.200 0.005 TF:M05874_0 tf 1 Factor: ZNF564; motif: KGGWHGTGAACM; match class: 0 1 Q96DI7,O43290 430 3.65e-02 413 10 5 0.500 0.012 HP:0000036 hp 1 Abnormality of the penis 1 O94906,O60828,Q8WWY3,O43395,O43172 430 3.69e-02 1535 10 5 0.500 0.003 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 3.79e-02 49 10 1 0.100 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 O43395 430 3.79e-02 997 10 3 0.300 0.003 TF:M01112_0 tf 1 Factor: RBP-Jkappa; motif: ANCGTGGGAAM; match class: 0 1 O94906,Q9BUQ8,O43290 430 3.89e-02 2271 10 6 0.600 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.92e-02 2274 10 6 0.600 0.003 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.92e-02 2274 10 6 0.600 0.003 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 3.95e-02 1559 10 5 0.500 0.003 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.00e-02 264 10 4 0.400 0.015 HP:0000580 hp 1 Pigmentary retinopathy 1 O94906,Q8WWY3,O43395,O43172 430 4.01e-02 484 10 3 0.300 0.006 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 O60828,Q8WWY3,O43172 430 4.03e-02 416 10 2 0.200 0.005 TF:M00222_1 tf 1 Factor: Hand1:E47; motif: NNNNGNRTCTGGMWTT; match class: 1 1 Q8WWY3,O43172 430 4.08e-02 419 10 2 0.200 0.005 TF:M01801_0 tf 1 Factor: ER-alpha; motif: AGGTCACNGTGACCT; match class: 0 1 Q96DI7,O94906 430 4.11e-02 2295 10 6 0.600 0.003 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.12e-02 969 10 4 0.400 0.004 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q96DI7,O60828,Q8WWY3,O43172 430 4.15e-02 6101 10 8 0.800 0.001 TF:M00981_0 tf 1 Factor: CREB,; motif: NTGACGTNA; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8 430 4.16e-02 1578 10 5 0.500 0.003 HPA:032010_03 hpa 1 salivary gland; glandular cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,Q9BUQ8 430 4.16e-02 54 10 1 0.100 0.019 TF:M05980_0 tf 1 Factor: zfp64; motif: NATACGGMTC; match class: 0 1 O43290 430 4.17e-02 2705 10 5 0.500 0.002 TF:M01864_0 tf 1 Factor: ATF-4; motif: KACGTCAKS; match class: 0 1 Q96DI7,Q8WWY3,O43395,O43172,Q9BUQ8 430 4.17e-02 424 10 2 0.200 0.005 TF:M07398_0 tf 1 Factor: Brn-3b; motif: RCTCATTAAN; match class: 0 1 Q9Y2W2,O43395 430 4.18e-02 973 10 4 0.400 0.004 HPA:023010_03 hpa 1 lymph node; germinal center cells[Uncertain,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 4.21e-02 1583 10 5 0.500 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.24e-02 977 10 4 0.400 0.004 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 Q96DI7,O60828,Q8WWY3,O43172 430 4.25e-02 2310 10 6 0.600 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.28e-02 1589 10 5 0.500 0.003 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.28e-02 1589 10 5 0.500 0.003 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.32e-02 56 10 1 0.100 0.018 TF:M00447_1 tf 1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 1 Q53GS9 430 4.32e-02 2318 10 6 0.600 0.003 HPA:044020_03 hpa 1 testis; cells in seminiferous ducts[Uncertain,High] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 4.33e-02 270 10 4 0.400 0.015 HP:0008736 hp 1 Hypoplasia of penis 1 O94906,Q8WWY3,O43395,O43172 430 4.42e-02 2328 10 6 0.600 0.003 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.51e-02 7612 10 9 0.900 0.001 TF:M05386_0 tf 1 Factor: KLF17; motif: NGGGCGG; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8 430 4.51e-02 7612 10 9 0.900 0.001 TF:M05499_0 tf 1 Factor: LKLF; motif: NGGGCGG; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8 430 4.54e-02 59 10 1 0.100 0.017 TF:M05523_0 tf 1 Factor: ZBTB46; motif: NGGGGGATAGN; match class: 0 1 Q53GS9 430 4.54e-02 59 10 1 0.100 0.017 TF:M06133_0 tf 1 Factor: ZNF17; motif: NGCTCCTGGARC; match class: 0 1 Q53GS9 430 4.56e-02 2342 10 6 0.600 0.003 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q96DI7,Q9Y2W2,O60828,Q8WWY3,O43172,Q9BUQ8 430 4.61e-02 509 10 3 0.300 0.006 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 O60828,Q8WWY3,Q9BUQ8 430 4.61e-02 7633 10 9 0.900 0.001 TF:M02012_0 tf 1 Factor: HIF-1alpha; motif: NCACGT; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 4.63e-02 1078 10 3 0.300 0.003 TF:M00414_1 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 1 1 Q96DI7,O43395,O43290 430 4.65e-02 9366 10 10 1.000 0.001 TF:M00456_1 tf 1 Factor: FAC1; motif: NNNCAMAACACRNA; match class: 1 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 4.67e-02 1621 10 5 0.500 0.003 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.68e-02 1622 10 5 0.500 0.003 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.69e-02 6216 10 8 0.800 0.001 TF:M04325_0 tf 1 Factor: GSC2; motif: NNTAATCCNN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,O43290 430 4.69e-02 1623 10 5 0.500 0.003 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172 430 4.70e-02 3206 10 7 0.700 0.002 HPA:019010_02 hpa 1 kidney; cells in glomeruli[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 4.70e-02 6218 10 8 0.800 0.001 TF:M03557_0 tf 1 Factor: P50; motif: GGRRANTCCCNN; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,O43395,O43172,Q53GS9,Q9BUQ8 430 4.73e-02 1087 10 3 0.300 0.003 TF:M00178_0 tf 1 Factor: CREB; motif: NSTGACGTMANN; match class: 0 1 Q96DI7,O43395,O43172 430 4.74e-02 5354 10 9 0.900 0.002 HPA:006010_02 hpa 1 cerebellum; Purkinje cells[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 4.75e-02 7661 10 9 0.900 0.001 TF:M00380_0 tf 1 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC; match class: 0 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 4.78e-02 6233 10 8 0.800 0.001 TF:M01660_1 tf 1 Factor: GABPalpha; motif: CTTCCK; match class: 1 1 Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q9BUQ8,O43290 430 4.80e-02 2366 10 6 0.600 0.003 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 4.94e-02 3233 10 7 0.700 0.002 HPA:041010_02 hpa 1 spleen; cells in red pulp[Uncertain,Medium] 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43172,Q9BUQ8 430 4.99e-02 65 10 1 0.100 0.015 TF:M06787_0 tf 1 Factor: ZNF780B; motif: KGTGGAAAAAGM; match class: 0 1 O60828 430 5.00e-02 1 10 1 0.100 1.000 OMIM:601414 omi 1 RETINITIS PIGMENTOSA 18; RP18 1 O43395 430 5.00e-02 1 10 1 0.100 1.000 OMIM:613983 omi 1 RETINITIS PIGMENTOSA 60; RP60 1 O94906 430 5.00e-02 1 10 1 0.100 1.000 OMIM:309500 omi 1 RENPENNING SYNDROME 1; RENS1;;MENTAL RETARDATION, X-LINKED, RENPENNING TYPE;;SUTHERLAND-HAAN X-LINKED MENTAL RETARDATION SYNDROME; SHS;;GOLABI-ITO-HALL SYNDROME;;MENTAL RETARDATION, X-LINKED, WITH SPASTIC DIPLEGIA;;MENTAL RETARDATION, X-LINKED, SYNDROMIC 3; MRXS3;;MENTAL RETARDATION, X-LINKED, SYNDROMIC 8; MRXS8;;MENTAL RETARDATION, X-LINKED 55; MRX55 1 O60828 430 5.00e-02 15 10 1 0.100 0.067 GO:0005732 CC 1 small nucleolar ribonucleoprotein complex 1 Q96DI7 430 5.00e-02 2385 10 6 0.600 0.003 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q96DI7,O94906,O60828,Q8WWY3,O43172,O43290 430 5.00e-02 382 10 4 0.400 0.010 MI:mmu-miR-764-3p mi 1 MI:mmu-miR-764-3p 1 Q96DI7,O94906,O60828,Q8WWY3 430 5.00e-02 128 10 10 1.000 0.078 KEGG:03040 keg 1 Spliceosome 1 Q96DI7,Q9Y2W2,O94906,O60828,Q8WWY3,O43395,O43172,Q53GS9,Q9BUQ8,O43290 430 5.00e-02 4 10 1 0.100 0.250 HP:0001786 hp 1 Narrow foot 1 O60828 430 5.00e-02 79 10 4 0.400 0.051 CORUM:1181 cor 1 C complex spliceosome 1 Q96DI7,O94906,Q9BUQ8,O43290 430 5.00e-02 51 10 3 0.300 0.059 REAC:72165 rea 1 mRNA Splicing - Minor Pathway 1 Q96DI7,O94906,Q9BUQ8 430 5.00e-02 1 10 1 0.100 1.000 OMIM:615922 omi 1 RETINITIS PIGMENTOSA 70; RP70 1 O43172 431 3.86e-03 1 6 1 0.167 1.000 GO:0006062 BP 1 sorbitol catabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0006060 BP 1 sorbitol metabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0019527 BP 1 pentitol catabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0006059 BP 1 hexitol metabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0034545 MF 1 fumarylpyruvate hydrolase activity 1 Q6P587 431 3.86e-03 1 6 1 0.167 1.000 GO:0046526 MF 1 D-xylulose reductase activity 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0051164 BP 1 L-xylitol metabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0018773 MF 1 acetylpyruvate hydrolase activity 1 Q6P587 431 3.86e-03 1 6 1 0.167 1.000 GO:0008948 MF 1 oxaloacetate decarboxylase activity 1 Q6P587 431 3.86e-03 1 6 1 0.167 1.000 GO:0003939 MF 1 L-iditol 2-dehydrogenase activity 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0019407 BP 1 hexitol catabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0051160 BP 1 L-xylitol catabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0019519 BP 1 pentitol metabolic process 1 Q00796 431 3.86e-03 1 6 1 0.167 1.000 GO:0031320 MF 1 hexitol dehydrogenase activity 1 Q00796 431 3.93e-03 353 6 3 0.500 0.008 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 Q00796,Q16798,Q2TB90 431 4.68e-03 76 6 2 0.333 0.026 GO:0006090 BP 1 pyruvate metabolic process 1 Q16798,Q2TB90 431 4.83e-03 32 6 2 0.333 0.062 KEGG:00051 keg 1 Fructose and mannose metabolism 1 Q00796,Q2TB90 431 6.56e-03 90 6 2 0.333 0.022 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Q00796,Q16798 431 7.61e-03 97 6 2 0.333 0.021 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 Q00796,Q2TB90 431 7.71e-03 2 6 1 0.167 0.500 GO:0019405 BP 1 alditol catabolic process 1 Q00796 431 7.71e-03 2 6 1 0.167 0.500 GO:0035370 CC 1 UBC13-UEV1A complex 1 Q13404 431 7.71e-03 2 6 1 0.167 0.500 GO:0072592 BP 1 oxygen metabolic process 1 Q16798 431 7.71e-03 2 6 1 0.167 0.500 GO:0046370 BP 1 fructose biosynthetic process 1 Q00796 431 7.71e-03 2 6 1 0.167 0.500 GO:0004473 MF 1 malate dehydrogenase (decarboxylating) (NADP+) activity 1 Q16798 431 7.77e-03 98 6 2 0.333 0.020 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 Q00796,Q16798 431 8.33e-03 1229 6 4 0.667 0.003 TF:M01116_0 tf 1 Factor: CLOCK:BMAL; motif: MCACGTGR; match class: 0 1 Q16798,Q2TB90,Q8TF09,Q6P587 431 8.41e-03 102 6 2 0.333 0.020 GO:0016052 BP 1 carbohydrate catabolic process 1 Q00796,Q2TB90 431 9.48e-03 4184 6 6 1.000 0.001 TF:M00476_0 tf 1 Factor: FOXO4; motif: NNGTTGTTTACNTN; match class: 0 1 Q00796,Q16798,Q2TB90,Q8TF09,Q6P587,Q13404 431 1.02e-02 4233 6 6 1.000 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 Q00796,Q16798,Q2TB90,Q8TF09,Q6P587,Q13404 431 1.12e-02 118 6 2 0.333 0.017 GO:0048037 MF 1 cofactor binding 1 Q00796,Q16798 431 1.16e-02 3 6 1 0.167 0.333 GO:0016822 MF 1 hydrolase activity, acting on acid carbon-carbon bonds 1 Q6P587 431 1.16e-02 3 6 1 0.167 0.333 GO:0016823 MF 1 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances 1 Q6P587 431 1.32e-02 4019 6 6 1.000 0.001 GO:0003824 MF 1 catalytic activity 1 Q00796,Q16798,Q2TB90,Q8TF09,Q6P587,Q13404 431 1.50e-02 370 6 2 0.333 0.005 MI:hsa-miR-510 mi 1 MI:hsa-miR-510 1 Q8TF09,Q6P587 431 1.54e-02 4 6 1 0.167 0.250 GO:0004470 MF 1 malic enzyme activity 1 Q16798 431 1.62e-02 386 6 2 0.333 0.005 MI:hsa-miR-624 mi 1 MI:hsa-miR-624 1 Q00796,Q2TB90 431 1.66e-02 4594 6 6 1.000 0.001 TF:M02014_1 tf 1 Factor: HNF-3beta; motif: NTRTTTRYT; match class: 1 1 Q00796,Q16798,Q2TB90,Q8TF09,Q6P587,Q13404 431 1.67e-02 2 6 1 0.167 0.500 REAC:5652227 rea 1 Fructose biosynthesis 1 Q00796 431 1.92e-02 1529 6 4 0.667 0.003 TF:M07384_0 tf 1 Factor: HIF-1alpha; motif: NCACGTNN; match class: 0 1 Q00796,Q16798,Q2TB90,Q6P587 431 1.93e-02 5 6 1 0.167 0.200 GO:0051167 BP 1 xylulose 5-phosphate metabolic process 1 Q00796 431 1.93e-02 5 6 1 0.167 0.200 GO:0045505 MF 1 dynein intermediate chain binding 1 Q8TF09 431 1.93e-02 5 6 1 0.167 0.200 GO:0019158 MF 1 mannokinase activity 1 Q2TB90 431 1.93e-02 5 6 1 0.167 0.200 GO:0006064 BP 1 glucuronate catabolic process 1 Q00796 431 1.93e-02 5 6 1 0.167 0.200 GO:1901159 BP 1 xylulose 5-phosphate biosynthetic process 1 Q00796 431 1.93e-02 5 6 1 0.167 0.200 GO:0008865 MF 1 fructokinase activity 1 Q2TB90 431 1.93e-02 5 6 1 0.167 0.200 GO:0004340 MF 1 glucokinase activity 1 Q2TB90 431 1.93e-02 5 6 1 0.167 0.200 GO:0019640 BP 1 glucuronate catabolic process to xylulose 5-phosphate 1 Q00796 431 1.93e-02 5 6 1 0.167 0.200 GO:0004396 MF 1 hexokinase activity 1 Q2TB90 431 2.01e-02 2 6 1 0.167 0.500 CORUM:2748 cor 1 Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2) 1 Q13404 431 2.01e-02 2 6 1 0.167 0.500 CORUM:6025 cor 1 UBC13-UEV1a complex 1 Q13404 431 2.10e-02 442 6 2 0.333 0.005 MI:hsa-miR-182 mi 1 MI:hsa-miR-182 1 Q00796,Q6P587 431 2.23e-02 457 6 2 0.333 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 Q16798,Q6P587 431 2.31e-02 6 6 1 0.167 0.167 GO:0016615 MF 1 malate dehydrogenase activity 1 Q16798 431 2.31e-02 6 6 1 0.167 0.167 GO:0006108 BP 1 malate metabolic process 1 Q16798 431 2.32e-02 650 6 3 0.500 0.005 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q00796,Q16798,Q2TB90 431 2.33e-02 467 6 2 0.333 0.004 MI:hsa-miR-135b mi 1 MI:hsa-miR-135b 1 Q2TB90,Q8TF09 431 2.56e-02 491 6 2 0.333 0.004 MI:hsa-miR-135a mi 1 MI:hsa-miR-135a 1 Q2TB90,Q8TF09 431 2.79e-02 514 6 2 0.333 0.004 MI:hsa-miR-199a-5p mi 1 MI:hsa-miR-199a-5p 1 Q2TB90,Q8TF09 431 2.96e-02 531 6 2 0.333 0.004 MI:hsa-miR-132 mi 1 MI:hsa-miR-132 1 Q2TB90,Q8TF09 431 3.23e-02 729 6 3 0.500 0.004 GO:0043436 BP 1 oxoacid metabolic process 1 Q00796,Q16798,Q2TB90 431 3.35e-02 739 6 3 0.500 0.004 GO:0006082 BP 1 organic acid metabolic process 1 Q00796,Q16798,Q2TB90 431 3.46e-02 9 6 1 0.167 0.111 GO:0031371 CC 1 ubiquitin conjugating enzyme complex 1 Q13404 431 3.46e-02 9 6 1 0.167 0.111 GO:0019400 BP 1 alditol metabolic process 1 Q00796 431 4.17e-02 5 6 1 0.167 0.200 REAC:5661270 rea 1 Catabolism of glucuronate to xylulose-5-phosphate 1 Q00796 431 4.23e-02 11 6 1 0.167 0.091 GO:0046174 BP 1 polyol catabolic process 1 Q00796 431 4.23e-02 11 6 1 0.167 0.091 GO:0006000 BP 1 fructose metabolic process 1 Q00796 431 4.90e-02 3420 6 5 0.833 0.001 TF:M04237_0 tf 1 Factor: FOXC2; motif: WAWGTAAACAWW; match class: 0 1 Q00796,Q16798,Q2TB90,Q8TF09,Q6P587 431 5.00e-02 933 6 3 0.500 0.003 TF:M00095_0 tf 1 Factor: CDP; motif: CCAATAATCGAT; match class: 0 1 Q16798,Q2TB90,Q8TF09 431 5.00e-02 6 6 1 0.167 0.167 REAC:5652084 rea 1 Fructose metabolism 1 Q00796 431 5.00e-02 5 6 1 0.167 0.200 KEGG:00524 keg 1 Neomycin, kanamycin and gentamicin biosynthesis 1 Q2TB90 431 5.00e-02 13 6 1 0.167 0.077 GO:0005868 CC 1 cytoplasmic dynein complex 1 Q8TF09 431 5.00e-02 5 6 1 0.167 0.200 CORUM:2745 cor 1 Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) 1 Q13404 432 1.75e-25 12 8 8 1.000 0.667 GO:0017119 CC 1 Golgi transport complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 6.27e-20 44 8 8 1.000 0.182 GO:0099023 CC 1 tethering complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.46e-19 8 8 8 1.000 1.000 CORUM:3522 cor 1 COG complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.46e-19 8 8 8 1.000 1.000 CORUM:162 cor 1 Conserved oligomeric Golgi (COG) complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.46e-19 8 8 8 1.000 1.000 CORUM:3556 cor 1 COG complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 3.77e-18 71 8 8 1.000 0.113 GO:0032588 CC 1 trans-Golgi network membrane 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.07e-17 31 8 7 0.875 0.226 GO:0006891 BP 1 intra-Golgi vesicle-mediated transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,Q96MW5 432 1.58e-15 147 8 8 1.000 0.054 GO:0005802 CC 1 trans-Golgi network 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.19e-15 153 8 8 1.000 0.052 GO:0006888 BP 1 ER to Golgi vesicle-mediated transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.94e-15 169 8 8 1.000 0.047 GO:0098791 CC 1 Golgi subcompartment 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 9.04e-15 182 8 8 1.000 0.044 GO:0031984 CC 1 organelle subcompartment 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 5.66e-14 41 8 8 1.000 0.195 REAC:6811438 rea 1 Intra-Golgi traffic 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.86e-13 47 8 8 1.000 0.170 REAC:6811440 rea 1 Retrograde transport at the Trans-Golgi-Network 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.83e-13 278 8 8 1.000 0.029 GO:0048193 BP 1 Golgi vesicle transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.19e-12 332 8 8 1.000 0.024 GO:0000139 CC 1 Golgi membrane 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 7.96e-12 73 8 8 1.000 0.110 REAC:6807878 rea 1 COPI-mediated anterograde transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.41e-11 482 8 8 1.000 0.017 GO:0044431 CC 1 Golgi apparatus part 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.64e-10 119 8 8 1.000 0.067 REAC:199977 rea 1 ER to Golgi Anterograde Transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.95e-10 5 8 5 0.625 1.000 CORUM:3552 cor 1 COG1-COG8-COG5-COG6-COG7 subcomplex 1 Q9Y2V7,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.95e-10 5 8 5 0.625 1.000 CORUM:3551 cor 1 COG1-COG8-COG2-COG3-COG4 subcomplex 1 Q9H9E3,Q14746,Q96JB2,Q8WTW3,Q96MW5 432 1.99e-09 142 8 8 1.000 0.056 REAC:948021 rea 1 Transport to the Golgi and subsequent modification 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.23e-09 846 8 8 1.000 0.009 GO:0005794 CC 1 Golgi apparatus 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 3.28e-09 87 8 5 0.625 0.057 GO:0007030 BP 1 Golgi organization 1 Q9H9E3,Q14746,Q96JB2,Q8WTW3,P83436 432 5.42e-09 945 8 8 1.000 0.008 GO:0098588 CC 1 bounding membrane of organelle 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 6.05e-09 958 8 8 1.000 0.008 GO:0016192 BP 1 vesicle-mediated transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 9.09e-09 171 8 8 1.000 0.047 REAC:6811442 rea 1 Intra-Golgi and retrograde Golgi-to-ER traffic 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.70e-08 1237 8 8 1.000 0.006 GO:0046907 BP 1 intracellular transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 5.04e-08 9 8 3 0.375 0.333 GO:0000301 BP 1 retrograde transport, vesicle recycling within Golgi 1 Q9H9E3,Q96JB2,Q8WTW3 432 1.38e-07 1414 8 8 1.000 0.006 GO:0031090 CC 1 organelle membrane 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.87e-07 248 8 8 1.000 0.032 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.13e-07 1493 8 8 1.000 0.005 GO:0051649 BP 1 establishment of localization in cell 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.84e-07 4 8 4 0.500 1.000 CORUM:3525 cor 1 Tetrameric COG subcomplex 1 Q9Y2V7,Q9UP83,P83436,Q96MW5 432 1.12e-06 1836 8 8 1.000 0.004 GO:0051641 BP 1 cellular localization 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 3.23e-06 2096 8 8 1.000 0.004 GO:0043234 CC 1 protein complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 5.90e-06 2260 8 8 1.000 0.004 GO:0012505 CC 1 endomembrane system 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 7.24e-06 404 8 5 0.625 0.012 GO:0010256 BP 1 endomembrane system organization 1 Q9H9E3,Q14746,Q96JB2,Q8WTW3,P83436 432 2.07e-05 2644 8 8 1.000 0.003 GO:0006810 BP 1 transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.83e-05 2748 8 8 1.000 0.003 GO:0051234 BP 1 establishment of localization 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 3.96e-05 75 8 3 0.375 0.040 GO:0006890 BP 1 retrograde vesicle-mediated transport, Golgi to ER 1 Q9H9E3,Q96JB2,P83436 432 7.67e-05 522 8 8 1.000 0.015 REAC:199991 rea 1 Membrane Trafficking 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.15e-04 549 8 8 1.000 0.015 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.31e-04 3 8 3 0.375 1.000 CORUM:3544 cor 1 COG2-COG3-COG4 subcomplex 1 Q9H9E3,Q14746,Q96JB2 432 1.31e-04 3 8 3 0.375 1.000 CORUM:3545 cor 1 COG5-COG6-COG7 subcomplex 1 Q9Y2V7,Q9UP83,P83436 432 1.31e-04 3 8 3 0.375 1.000 CORUM:3529 cor 1 Ternary COG subcomplex 1 Q9Y2V7,Q9UP83,P83436 432 1.56e-04 3401 8 8 1.000 0.002 GO:0051179 BP 1 localization 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.61e-04 3415 8 8 1.000 0.002 GO:0032991 CC 1 macromolecular complex 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 4.66e-04 171 8 3 0.375 0.018 GO:0070085 BP 1 glycosylation 1 Q9Y2V7,Q96JB2,P83436 432 9.32e-04 712 8 8 1.000 0.011 REAC:597592 rea 1 Post-translational protein modification 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.66e-03 362 8 3 0.375 0.008 MI:mmu-miR-683 mi 1 MI:mmu-miR-683 1 Q9H9E3,P83436,Q96MW5 432 1.75e-03 4600 8 8 1.000 0.002 GO:0016020 CC 1 membrane 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 2.50e-03 67 8 2 0.250 0.030 GO:0008565 MF 1 protein transporter activity 1 Q14746,Q96JB2 432 3.81e-03 2 8 1 0.125 0.500 GO:0048213 BP 1 Golgi vesicle prefusion complex stabilization 1 Q9H9E3 432 5.06e-03 2791 8 6 0.750 0.002 HPA:007020_02 hpa 1 cerebral cortex; glial cells[Uncertain,Medium] 1 Q9H9E3,Q9Y2V7,Q96JB2,Q9UP83,Q8WTW3,P83436 432 5.97e-03 104 8 2 0.250 0.019 GO:0050821 BP 1 protein stabilization 1 Q96JB2,P83436 432 6.05e-03 549 8 3 0.375 0.005 HPA:039030_03 hpa 1 soft tissue 1; fibroblasts[Uncertain,High] 1 Q9H9E3,Q9UP83,P83436 432 8.80e-03 5629 8 8 1.000 0.001 GO:0044444 CC 1 cytoplasmic part 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 9.81e-03 653 8 3 0.375 0.005 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 Q96JB2,Q9UP83,Q8WTW3 432 1.10e-02 5787 8 8 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.24e-02 5877 8 8 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 1.43e-02 162 8 2 0.250 0.012 GO:0031647 BP 1 regulation of protein stability 1 Q96JB2,P83436 432 1.49e-02 272 8 2 0.250 0.007 MI:hsa-miR-744* mi 1 MI:hsa-miR-744* 1 Q9H9E3,Q8WTW3 432 1.55e-02 169 8 2 0.250 0.012 GO:0043413 BP 1 macromolecule glycosylation 1 Q96JB2,P83436 432 1.55e-02 169 8 2 0.250 0.012 GO:0006486 BP 1 protein glycosylation 1 Q96JB2,P83436 432 1.87e-02 306 8 2 0.250 0.007 MI:mmu-miR-681 mi 1 MI:mmu-miR-681 1 Q9H9E3,Q96MW5 432 2.13e-02 867 8 3 0.375 0.003 HPA:027020_03 hpa 1 pancreas; islets of Langerhans[Uncertain,High] 1 Q9H9E3,Q96JB2,P83436 432 2.19e-02 333 8 2 0.250 0.006 MI:hsa-miR-141* mi 1 MI:hsa-miR-141* 1 Q14746,Q96MW5 432 2.20e-02 334 8 2 0.250 0.006 MI:hsa-miR-942 mi 1 MI:hsa-miR-942 1 Q9H9E3,Q14746 432 2.25e-02 2343 8 6 0.750 0.003 TF:M03981_0 tf 1 Factor: ETV3; motif: ACCGGAAGTN; match class: 0 1 Q9H9E3,Q9Y2V7,Q96JB2,Q9UP83,Q8WTW3,P83436 432 2.25e-02 338 8 2 0.250 0.006 MI:hsa-miR-346 mi 1 MI:hsa-miR-346 1 Q9H9E3,Q96MW5 432 2.27e-02 339 8 2 0.250 0.006 MI:hsa-miR-26b* mi 1 MI:hsa-miR-26b* 1 P83436,Q96MW5 432 2.61e-02 2262 8 5 0.625 0.002 GO:0006996 BP 1 organelle organization 1 Q9H9E3,Q14746,Q96JB2,Q8WTW3,P83436 432 2.65e-02 223 8 2 0.250 0.009 GO:0009101 BP 1 glycoprotein biosynthetic process 1 Q96JB2,P83436 432 2.93e-02 389 8 2 0.250 0.005 MI:hsa-miR-92a-2* mi 1 MI:hsa-miR-92a-2* 1 Q9H9E3,P83436 432 3.09e-02 400 8 2 0.250 0.005 MI:hsa-miR-601 mi 1 MI:hsa-miR-601 1 Q9H9E3,P83436 432 3.13e-02 403 8 2 0.250 0.005 MI:rno-miR-349 mi 1 MI:rno-miR-349 1 P83436,Q96MW5 432 3.20e-02 246 8 2 0.250 0.008 GO:0009100 BP 1 glycoprotein metabolic process 1 Q96JB2,P83436 432 3.21e-02 2805 8 5 0.625 0.002 HPA:007010_02 hpa 1 cerebral cortex; endothelial cells[Uncertain,Medium] 1 Q9H9E3,Q96JB2,Q9UP83,Q8WTW3,P83436 432 3.41e-02 422 8 2 0.250 0.005 MI:hsa-miR-885-5p mi 1 MI:hsa-miR-885-5p 1 Q14746,Q96MW5 432 3.43e-02 6671 8 8 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 3.53e-02 430 8 2 0.250 0.005 MI:hsa-miR-450b-3p mi 1 MI:hsa-miR-450b-3p 1 Q14746,Q9UP83 432 3.59e-02 434 8 2 0.250 0.005 MI:hsa-miR-139-3p mi 1 MI:hsa-miR-139-3p 1 Q9H9E3,Q14746 432 3.62e-02 1890 8 4 0.500 0.002 HPA:044010_03 hpa 1 testis; Leydig cells[Uncertain,High] 1 Q9H9E3,Q96JB2,Q9UP83,P83436 432 3.67e-02 2 8 1 0.125 0.500 TF:M06229_1 tf 1 Factor: ZNF91; motif: NGGGGCGGMWGC; match class: 1 1 Q8WTW3 432 3.76e-02 445 8 2 0.250 0.004 MI:hsa-miR-509-3-5p mi 1 MI:hsa-miR-509-3-5p 1 P83436,Q96MW5 432 3.76e-02 88 8 2 0.250 0.023 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 Q9UP83,Q8WTW3 432 3.79e-02 20 8 1 0.125 0.050 GO:0034067 BP 1 protein localization to Golgi apparatus 1 P83436 432 4.03e-02 462 8 2 0.250 0.004 MI:hsa-miR-323-5p mi 1 MI:hsa-miR-323-5p 1 P83436,Q96MW5 432 4.11e-02 467 8 2 0.250 0.004 MI:hsa-miR-135b mi 1 MI:hsa-miR-135b 1 Q14746,P83436 432 4.51e-02 491 8 2 0.250 0.004 MI:hsa-miR-135a mi 1 MI:hsa-miR-135a 1 Q14746,P83436 432 4.68e-02 501 8 2 0.250 0.004 MI:hsa-miR-142-3p mi 1 MI:hsa-miR-142-3p 1 Q9H9E3,Q8WTW3 432 4.89e-02 495 8 2 0.250 0.004 HPA:040030_03 hpa 1 soft tissue 2; fibroblasts[Uncertain,High] 1 Q9UP83,P83436 432 5.00e-02 1 8 1 0.125 1.000 OMIM:608779 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIe; CDG2E;;CDG IIe; CDGIIe 1 P83436 432 5.00e-02 2 8 2 0.250 1.000 CORUM:3530 cor 1 Binary COG subcomplex 1 Q9UP83,P83436 432 5.00e-02 1 8 1 0.125 1.000 OMIM:615328 omi 1 SHAHEEN SYNDROME; SHNS 1 Q9Y2V7 432 5.00e-02 19 8 3 0.375 0.158 HP:0012345 hp 1 Abnormal glycosylation 1 Q9Y2V7,Q9UP83,Q8WTW3 432 5.00e-02 2 8 2 0.250 1.000 CORUM:3532 cor 1 COG1-COG8 subcomplex 1 Q8WTW3,Q96MW5 432 5.00e-02 1 8 1 0.125 1.000 OMIM:613612 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIi; CDG2I;;CDG IIi; CDGIIi 1 Q9UP83 432 5.00e-02 19 8 3 0.375 0.158 HP:0003160 hp 1 Abnormal isoelectric focusing of serum transferrin 1 Q9Y2V7,Q9UP83,Q8WTW3 432 5.00e-02 19 8 3 0.375 0.158 HP:0012347 hp 1 Abnormal protein N-linked glycosylation 1 Q9Y2V7,Q9UP83,Q8WTW3 432 5.00e-02 1 8 1 0.125 1.000 OMIM:614576 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl; CDG2L;;CDG IIl; CDGIIl 1 Q9Y2V7 432 5.00e-02 1 8 1 0.125 1.000 OMIM:613489 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj; CDG2J;;CDG IIj; CDGIIj 1 Q9H9E3 432 5.00e-02 1169 8 8 1.000 0.007 REAC:392499 rea 1 Metabolism of proteins 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 5.00e-02 1 8 1 0.125 1.000 OMIM:611209 omi 1 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIg; CDG2G;;CDG IIg; CDGIIg;;CDGII/COG1 CEREBROCOSTOMANDIBULAR-LIKE SYNDROME 1 Q8WTW3 432 5.00e-02 6993 8 8 1.000 0.001 GO:0005737 CC 1 cytoplasm 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q9UP83,Q8WTW3,P83436,Q96MW5 432 5.00e-02 19 8 3 0.375 0.158 HP:0012346 hp 1 Abnormal protein glycosylation 1 Q9Y2V7,Q9UP83,Q8WTW3 432 5.00e-02 2702 8 6 0.750 0.002 TF:M01078_0 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 0 1 Q9H9E3,Q9Y2V7,Q14746,Q96JB2,Q8WTW3,P83436 433 5.65e-03 24 3 1 0.333 0.042 TF:M04471_1 tf 1 Factor: NR2E1; motif: AAGTCAANAAGTCA; match class: 1 1 Q8IUC8 433 5.73e-03 565 3 2 0.667 0.004 TF:M02261_1 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 1 1 P51805,Q96JA1 433 5.88e-03 25 3 1 0.333 0.040 TF:M06257_0 tf 1 Factor: ZNF616; motif: RTGGTGGRGATGCCM; match class: 0 1 P51805 433 7.99e-03 669 3 2 0.667 0.003 TF:M06008_0 tf 1 Factor: ZBTB40; motif: KTCSTATTY; match class: 0 1 P51805,Q8IUC8 433 8.23e-03 35 3 1 0.333 0.029 TF:M05525_0 tf 1 Factor: ZBTB41; motif: TGGGCCCCCGA; match class: 0 1 P51805 433 8.37e-03 685 3 2 0.667 0.003 TF:M04080_0 tf 1 Factor: POU3F3; motif: WWTATGCWAATTW; match class: 0 1 Q8IUC8,Q96JA1 433 8.70e-03 37 3 1 0.333 0.027 TF:M06703_0 tf 1 Factor: ZNF160; motif: NGGKAAAAATGA; match class: 0 1 Q8IUC8 433 1.48e-02 63 3 1 0.333 0.016 TF:M06647_0 tf 1 Factor: ZNF665; motif: NGGKCTTKATGA; match class: 0 1 Q96JA1 433 1.59e-02 13 3 1 0.333 0.077 REAC:399955 rea 1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1 P51805 433 1.69e-02 72 3 1 0.333 0.014 TF:M00058_1 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 1 1 P51805 433 1.73e-02 993 3 2 0.667 0.002 TF:M00001_0 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 0 1 Q8IUC8,Q96JA1 433 1.96e-02 1058 3 2 0.667 0.002 TF:M04083_0 tf 1 Factor: POU3F4; motif: TATGCWAAT; match class: 0 1 Q8IUC8,Q96JA1 433 1.96e-02 16 3 1 0.333 0.062 REAC:399956 rea 1 CRMPs in Sema3A signaling 1 P51805 433 1.96e-02 16 3 1 0.333 0.062 REAC:399954 rea 1 Sema3A PAK dependent Axon repulsion 1 P51805 433 2.06e-02 88 3 1 0.333 0.011 TF:M06440_0 tf 1 Factor: ZNF493; motif: KGGGAAKAAGGA; match class: 0 1 Q96JA1 433 2.11e-02 1099 3 2 0.667 0.002 TF:M04070_0 tf 1 Factor: POU2F1; motif: NWTATGCWAATN; match class: 0 1 Q8IUC8,Q96JA1 433 2.39e-02 102 3 1 0.333 0.010 TF:M00793_1 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 1 1 Q8IUC8 433 2.59e-02 111 3 1 0.333 0.009 TF:M05462_0 tf 1 Factor: znf581; motif: NTGTGGGCAC; match class: 0 1 P51805 433 2.60e-02 1225 3 2 0.667 0.002 TF:M00807_1 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 1 P51805,Q96JA1 433 2.62e-02 112 3 1 0.333 0.009 TF:M06841_0 tf 1 Factor: ZNF507; motif: GTTATCCTCA; match class: 0 1 Q96JA1 433 2.73e-02 1256 3 2 0.667 0.002 TF:M02261_0 tf 1 Factor: ESR1; motif: NNNNMAGGTCACCCTGACCY; match class: 0 1 P51805,Q96JA1 433 2.76e-02 1264 3 2 0.667 0.002 TF:M00069_0 tf 1 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW; match class: 0 1 Q8IUC8,Q96JA1 433 2.80e-02 1273 3 2 0.667 0.002 TF:M00138_1 tf 1 Factor: Oct-1; motif: NNNNNNNWATGCAAATNNNWNNA; match class: 1 1 Q8IUC8,Q96JA1 433 2.80e-02 120 3 1 0.333 0.008 TF:M06463_0 tf 1 Factor: ZNF595; motif: NGKGGCGGCMGM; match class: 0 1 P51805 433 2.84e-02 1282 3 2 0.667 0.002 TF:M00135_1 tf 1 Factor: Oct-1; motif: NNNNWTATGCAAATNTNNN; match class: 1 1 Q8IUC8,Q96JA1 433 2.95e-02 1307 3 2 0.667 0.002 TF:M00793_0 tf 1 Factor: YY1; motif: GCCATNTTN; match class: 0 1 Q8IUC8,Q96JA1 433 3.10e-02 133 3 1 0.333 0.008 TF:M06387_0 tf 1 Factor: ZSCAN2; motif: NGGGWAAAACGC; match class: 0 1 Q96JA1 433 3.13e-02 5 3 1 0.333 0.200 GO:0021785 BP 1 branchiomotor neuron axon guidance 1 P51805 433 3.19e-02 137 3 1 0.333 0.007 TF:M06482_0 tf 1 Factor: ZNF547; motif: KGTTCCTGGMGA; match class: 0 1 Q96JA1 433 3.33e-02 2 3 1 0.333 0.500 CORUM:5759 cor 1 PLXNA3-RANBPM complex 1 P51805 433 3.44e-02 4142 3 3 1.000 0.001 TF:M01665_1 tf 1 Factor: IRF-8; motif: AGTTTCW; match class: 1 1 P51805,Q8IUC8,Q96JA1 433 3.52e-02 151 3 1 0.333 0.007 TF:M06047_0 tf 1 Factor: ZNF276; motif: NGYTRGGGACGC; match class: 0 1 P51805 433 3.66e-02 1464 3 2 0.667 0.001 TF:M00327_0 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 0 1 P51805,Q8IUC8 433 3.71e-02 1473 3 2 0.667 0.001 TF:M04076_0 tf 1 Factor: POU3F1; motif: WTATGCWAATNN; match class: 0 1 Q8IUC8,Q96JA1 433 4.05e-02 1543 3 2 0.667 0.001 TF:M04074_0 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 0 1 Q8IUC8,Q96JA1 433 4.11e-02 177 3 1 0.333 0.006 TF:M00058_0 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 0 1 P51805 433 4.38e-02 7 3 1 0.333 0.143 GO:1902287 BP 1 semaphorin-plexin signaling pathway involved in axon guidance 1 P51805 433 4.44e-02 191 3 1 0.333 0.005 TF:M07217_0 tf 1 Factor: MAX; motif: RRGCACATGK; match class: 0 1 Q8IUC8 433 4.71e-02 203 3 1 0.333 0.005 TF:M05821_0 tf 1 Factor: ZNF880; motif: GGAGGGCTYK; match class: 0 1 Q96JA1 433 5.00e-02 3 3 1 0.333 0.333 CORUM:5648 cor 1 FARP2-NRP1-PlexinA3 complex 1 P51805 433 5.00e-02 8 3 1 0.333 0.125 GO:0004653 MF 1 polypeptide N-acetylgalactosaminyltransferase activity 1 Q8IUC8 433 5.00e-02 41 3 1 0.333 0.024 REAC:913709 rea 1 O-linked glycosylation of mucins 1 Q8IUC8 433 5.00e-02 308 3 2 0.667 0.006 MI:hsa-miR-432* mi 1 MI:hsa-miR-432* 1 P51805,Q96JA1 433 5.00e-02 19 3 1 0.333 0.053 KEGG:00512 keg 1 Mucin type O-glycan biosynthesis 1 Q8IUC8 434 1.88e-02 3 2 1 0.500 0.333 GO:0030158 MF 1 protein xylosyltransferase activity 1 Q4G148 434 2.85e-02 41 2 1 0.500 0.024 REAC:913709 rea 1 O-linked glycosylation of mucins 1 Q6P9A2 434 3.31e-02 340 2 2 1.000 0.006 MI:mmu-miR-694 mi 1 MI:mmu-miR-694 1 Q6P9A2,Q4G148 434 5.00e-02 72 2 1 0.500 0.014 REAC:5173105 rea 1 O-linked glycosylation 1 Q6P9A2 434 5.00e-02 418 2 2 1.000 0.005 MI:hsa-miR-620 mi 1 MI:hsa-miR-620 1 Q6P9A2,Q4G148 434 5.00e-02 8 2 1 0.500 0.125 GO:0035252 MF 1 UDP-xylosyltransferase activity 1 Q4G148 434 5.00e-02 8 2 1 0.500 0.125 GO:0042285 MF 1 xylosyltransferase activity 1 Q4G148 434 5.00e-02 19 2 1 0.500 0.053 KEGG:00512 keg 1 Mucin type O-glycan biosynthesis 1 Q6P9A2 434 5.00e-02 5 2 1 0.500 0.200 TF:M06563_0 tf 1 Factor: ZNF483; motif: NGGWTCGGCCTY; match class: 0 1 Q6P9A2 435 2.58e-03 332 3 2 0.667 0.006 MI:hsa-miR-23a* mi 1 MI:hsa-miR-23a* 1 Q9HCJ0,Q9UJY5 435 3.93e-03 411 3 2 0.667 0.005 MI:hsa-miR-29c* mi 1 MI:hsa-miR-29c* 1 Q9UJY5,Q9ULC3 435 1.17e-02 7 3 1 0.333 0.143 REAC:426496 rea 1 Post-transcriptional silencing by small RNAs 1 Q9HCJ0 435 1.32e-02 733 3 2 0.667 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q9UJY5,Q9ULC3 435 2.03e-02 914 3 2 0.667 0.002 HPA:040020_10 hpa 1 soft tissue 2; chondrocytes[Supportive,Not detected] 1 Q9UJY5,Q9ULC3 435 2.25e-02 965 3 2 0.667 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q9UJY5,Q9ULC3 435 2.42e-02 1002 3 2 0.667 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 2.86e-02 1091 3 2 0.667 0.002 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 3.08e-02 1135 3 2 0.667 0.002 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 3.69e-02 1247 3 2 0.667 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 4.34e-02 26 3 1 0.333 0.038 REAC:1912408 rea 1 Pre-NOTCH Transcription and Translation 1 Q9HCJ0 435 4.58e-02 1396 3 2 0.667 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 4.58e-02 1396 3 2 0.667 0.001 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 4.63e-02 1403 3 2 0.667 0.001 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 4.95e-02 1453 3 2 0.667 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9UJY5,Q9ULC3 435 5.00e-02 199 3 2 0.667 0.010 GO:0010008 CC 1 endosome membrane 1 Q9UJY5,Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0006397 hp 1 Lateral displacement of patellae 1 Q9ULC3 435 5.00e-02 1 3 1 0.333 1.000 OMIM:201000 omi 1 Carpenter Syndrome 1 Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0010008 hp 1 Duplication of the middle phalanx of hand 1 Q9ULC3 435 5.00e-02 30 3 1 0.333 0.033 REAC:2559585 rea 1 Oncogene Induced Senescence 1 Q9HCJ0 435 5.00e-02 2 3 1 0.333 0.500 HP:0010002 hp 1 Complete duplication of the middle phalanges of the hand 1 Q9ULC3 435 5.00e-02 1 3 1 0.333 1.000 TF:M05895_1 tf 1 Factor: ZNF454; motif: KGGTAYAKAATC; match class: 1 1 Q9HCJ0 435 5.00e-02 2 3 1 0.333 0.500 HP:0010202 hp 1 Duplication of middle phalanx of toe 1 Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0009608 hp 1 Complete duplication of proximal phalanx of the thumb 1 Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0009613 hp 1 Duplication of the proximal phalanx of the thumb 1 Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0010093 hp 1 Duplication of the proximal phalanx of the hallux 1 Q9ULC3 435 5.00e-02 2 3 1 0.333 0.500 HP:0010275 hp 1 Pseudoepiphyses of the proximal phalanges of the hand 1 Q9ULC3 436 5.54e-05 49 2 2 1.000 0.041 REAC:198933 rea 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1 Q8NHL6,O75019 436 2.11e-03 585 2 2 1.000 0.003 TF:M02085_1 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 1 1 Q8NHL6,O75019 436 3.11e-03 710 2 2 1.000 0.003 TF:M01203_0 tf 1 Factor: SPI1; motif: NNAAWGNGGAASTNNNN; match class: 0 1 Q8NHL6,O75019 436 3.77e-03 24 2 1 0.500 0.042 TF:M05753_0 tf 1 Factor: ZNF630; motif: NGTGTCAAGAAA; match class: 0 1 O75019 436 4.24e-03 27 2 1 0.500 0.037 TF:M06169_0 tf 1 Factor: ZNF83; motif: NTGTGAGAAGGA; match class: 0 1 O75019 436 5.18e-03 33 2 1 0.500 0.030 TF:M05741_0 tf 1 Factor: ZNF718; motif: NGGGGCWTCAGM; match class: 0 1 O75019 436 8.78e-03 1193 2 2 1.000 0.002 TF:M00998_0 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 0 1 Q8NHL6,O75019 436 8.87e-03 614 2 2 1.000 0.003 REAC:1280218 rea 1 Adaptive Immune System 1 Q8NHL6,O75019 436 9.09e-03 58 2 1 0.500 0.017 TF:M06719_1 tf 1 Factor: ZNF430; motif: NCGTAMAAAAGA; match class: 1 1 Q8NHL6 436 1.00e-02 64 2 1 0.500 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 Q8NHL6 436 1.00e-02 64 2 1 0.500 0.016 TF:M04594_1 tf 1 Factor: Zic3; motif: CCCGCTGGG; match class: 1 1 O75019 436 1.07e-02 68 2 1 0.500 0.015 TF:M06636_0 tf 1 Factor: ZNF599; motif: NRGAGTGTGGGC; match class: 0 1 O75019 436 1.39e-02 89 2 1 0.500 0.011 TF:M04229_0 tf 1 Factor: FOXB1; motif: GAATGACACRGCGA; match class: 0 1 Q8NHL6 436 1.42e-02 91 2 1 0.500 0.011 TF:M05431_0 tf 1 Factor: ZNF342; motif: AGGGAAACGM; match class: 0 1 Q8NHL6 436 1.74e-02 111 2 1 0.500 0.009 TF:M05462_0 tf 1 Factor: znf581; motif: NTGTGGGCAC; match class: 0 1 Q8NHL6 436 1.92e-02 123 2 1 0.500 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 O75019 436 2.28e-02 1921 2 2 1.000 0.001 TF:M01117_0 tf 1 Factor: OTX; motif: GATTANNT; match class: 0 1 Q8NHL6,O75019 436 2.30e-02 147 2 1 0.500 0.007 TF:M07091_0 tf 1 Factor: Fra-1; motif: RRTGASTCAKN; match class: 0 1 Q8NHL6 436 2.32e-02 1939 2 2 1.000 0.001 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 Q8NHL6,O75019 436 2.45e-02 157 2 1 0.500 0.006 TF:M04404_0 tf 1 Factor: MSX1; motif: NCAATTAAANNSCAATTA; match class: 0 1 Q8NHL6 436 2.68e-02 172 2 1 0.500 0.006 TF:M07351_1 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 1 1 O75019 436 2.68e-02 172 2 1 0.500 0.006 TF:M01204_0 tf 1 Factor: Spi-B; motif: AAAAWGMGGAAGTWNSN; match class: 0 1 O75019 436 2.72e-02 174 2 1 0.500 0.006 TF:M06320_0 tf 1 Factor: ZNF791; motif: NGGTTATGAMGA; match class: 0 1 Q8NHL6 436 2.76e-02 177 2 1 0.500 0.006 TF:M04407_1 tf 1 Factor: MSX2; motif: NCAATTAN; match class: 1 1 Q8NHL6 436 2.84e-02 2144 2 2 1.000 0.001 TF:M00971_1 tf 1 Factor: Ets; motif: ACTTCCTS; match class: 1 1 Q8NHL6,O75019 436 2.87e-02 184 2 1 0.500 0.005 TF:M00998_1 tf 1 Factor: Pbx; motif: GATTGATKGNNS; match class: 1 1 Q8NHL6 436 2.93e-02 188 2 1 0.500 0.005 TF:M05588_0 tf 1 Factor: ZNF18; motif: YKGGCWRAAGM; match class: 0 1 Q8NHL6 436 3.00e-02 2204 2 2 1.000 0.001 TF:M01029_0 tf 1 Factor: TFE; motif: TCATGTGN; match class: 0 1 Q8NHL6,O75019 436 3.16e-02 2264 2 2 1.000 0.001 TF:M02076_1 tf 1 Factor: Spi-B; motif: NGNGGAAGYN; match class: 1 1 Q8NHL6,O75019 436 3.16e-02 203 2 1 0.500 0.005 TF:M00699_1 tf 1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1 Q8NHL6 436 3.66e-02 235 2 1 0.500 0.004 TF:M04280_1 tf 1 Factor: ALX3; motif: NTAATYNAATTAN; match class: 1 1 Q8NHL6 436 3.70e-02 352 2 2 1.000 0.006 MI:hsa-miR-18b* mi 1 MI:hsa-miR-18b* 1 Q8NHL6,O75019 436 3.75e-02 241 2 1 0.500 0.004 TF:M04308_1 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 1 1 Q8NHL6 436 3.79e-02 2477 2 2 1.000 0.001 TF:M00073_0 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 0 1 Q8NHL6,O75019 436 3.81e-02 245 2 1 0.500 0.004 TF:M07235_1 tf 1 Factor: ZEB1; motif: NCWCACCTG; match class: 1 1 O75019 436 3.85e-02 2498 2 2 1.000 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 Q8NHL6,O75019 436 3.85e-02 2498 2 2 1.000 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 Q8NHL6,O75019 436 3.92e-02 252 2 1 0.500 0.004 TF:M01871_1 tf 1 Factor: COE1; motif: NCYCWRGGGANYNN; match class: 1 1 O75019 436 3.92e-02 252 2 1 0.500 0.004 TF:M03883_1 tf 1 Factor: REST; motif: CCNNGGTGCTGAA; match class: 1 1 O75019 436 3.94e-02 2527 2 2 1.000 0.001 TF:M02085_0 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 0 1 Q8NHL6,O75019 436 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 O75019 436 4.12e-02 265 2 1 0.500 0.004 TF:M04426_1 tf 1 Factor: PHOX2A; motif: TAATYYAATTA; match class: 1 1 Q8NHL6 436 4.20e-02 270 2 1 0.500 0.004 TF:M07076_0 tf 1 Factor: c-Jun:B-ATF; motif: RNWATGASTCA; match class: 0 1 Q8NHL6 436 4.31e-02 277 2 1 0.500 0.004 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 O75019 436 4.36e-02 2657 2 2 1.000 0.001 TF:M00132_0 tf 1 Factor: HNF1; motif: GGTTAATNWTTAMCN; match class: 0 1 Q8NHL6,O75019 436 4.46e-02 287 2 1 0.500 0.003 TF:M04381_1 tf 1 Factor: ISX; motif: NYAATTAN; match class: 1 1 Q8NHL6 436 4.46e-02 287 2 1 0.500 0.003 TF:M04416_1 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 1 1 Q8NHL6 436 4.51e-02 290 2 1 0.500 0.003 TF:M03556_0 tf 1 Factor: NF-AT5; motif: GGAAARYWCYAN; match class: 0 1 O75019 436 4.52e-02 2707 2 2 1.000 0.001 TF:M03837_0 tf 1 Factor: Oct3; motif: TKWNATGCAWATN; match class: 0 1 Q8NHL6,O75019 436 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q8NHL6,O75019 436 4.66e-02 2749 2 2 1.000 0.001 TF:M04347_1 tf 1 Factor: HOXB2; motif: NNTMATTANN; match class: 1 1 Q8NHL6,O75019 436 4.67e-02 301 2 1 0.500 0.003 TF:M07102_0 tf 1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 0 1 Q8NHL6 436 5.00e-02 90 2 2 1.000 0.022 KEGG:04380 keg 1 Osteoclast differentiation 1 Q8NHL6,O75019 436 5.00e-02 1457 2 2 1.000 0.001 REAC:168256 rea 1 Immune System 1 Q8NHL6,O75019 436 5.00e-02 42 2 1 0.500 0.024 GO:0003823 MF 1 antigen binding 1 O75019 437 1.11e-02 4 2 1 0.500 0.250 HP:0000798 hp 1 Oligospermia 1 Q8NBT0 437 1.95e-02 7 2 1 0.500 0.143 HP:0040255 hp 1 Aplasia/Hypoplasia of the clitoris 1 Q8NBT0 437 1.95e-02 7 2 1 0.500 0.143 HP:0000060 hp 1 Clitoral hypoplasia 1 Q8NBT0 437 2.78e-02 10 2 1 0.500 0.100 HP:0003187 hp 1 Breast hypoplasia 1 Q8NBT0 437 4.17e-02 15 2 1 0.500 0.067 HP:0000056 hp 1 Abnormality of the clitoris 1 Q8NBT0 437 4.38e-02 63 2 1 0.500 0.016 GO:0036064 CC 1 ciliary basal body 1 Q8NBT0 437 4.72e-02 17 2 1 0.500 0.059 HP:0100864 hp 1 Short femoral neck 1 Q8NBT0 437 5.00e-02 447 2 2 1.000 0.004 MI:hsa-miR-216b mi 1 MI:hsa-miR-216b 1 Q8NBT0,Q9NQ31 437 5.00e-02 1 2 1 0.500 1.000 OMIM:614813 omi 1 SHORT STATURE, ONYCHODYSPLASIA, FACIAL DYSMORPHISM, AND HYPOTRICHOSIS;SOFT;;SOFT SYNDROME 1 Q8NBT0 437 5.00e-02 72 2 1 0.500 0.014 GO:0005814 CC 1 centriole 1 Q8NBT0 437 5.00e-02 2 2 1 0.500 0.500 TF:M05619_1 tf 1 Factor: ZSCAN5C; motif: NMGTTWAACATG; match class: 1 1 Q9NQ31 437 5.00e-02 18 2 1 0.500 0.056 HP:0004590 hp 1 Hypoplastic sacrum 1 Q8NBT0 438 7.37e-04 153 2 2 1.000 0.013 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P38117,P00338 438 3.53e-03 1 2 1 0.500 1.000 GO:0017133 CC 1 mitochondrial electron transfer flavoprotein complex 1 P38117 438 3.53e-03 1 2 1 0.500 1.000 GO:0045251 CC 1 electron transfer flavoprotein complex 1 P38117 438 7.15e-03 1 2 1 0.500 1.000 OMIM:612933 omi 1 GLYCOGEN STORAGE DISEASE XI; GSD11;;GSD XI;;LACTATE DEHYDROGENASE A DEFICIENCY 1 P00338 438 1.01e-02 257 2 2 1.000 0.008 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P38117,P00338 438 1.19e-02 26 2 1 0.500 0.038 REAC:70268 rea 1 Pyruvate metabolism 1 P00338 438 1.41e-02 4 2 1 0.500 0.250 GO:0004457 MF 1 lactate dehydrogenase activity 1 P00338 438 1.41e-02 4 2 1 0.500 0.250 GO:0004459 MF 1 L-lactate dehydrogenase activity 1 P00338 438 1.90e-02 353 2 2 1.000 0.006 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P38117,P00338 438 2.06e-02 1550 2 2 1.000 0.001 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 P38117,P00338 438 2.10e-02 46 2 1 0.500 0.022 REAC:71406 rea 1 Pyruvate metabolism and Citric Acid (TCA) cycle 1 P00338 438 2.14e-02 3 2 1 0.500 0.333 OMIM:231680 omi 1 MULTIPLE ACYL-CoA DEHYDROGENASE DEFICIENCY; MADD;;GLUTARIC ACIDEMIA II;;GLUTARIC ACIDURIA II;;GA II;;ETHYLMALONIC-ADIPICACIDURIA; EMAGLUTARIC ACIDEMIA IIA, INCLUDED;;ETFA DEFICIENCY, INCLUDED;;GLUTARIC ACIDEMIA IIB, INCLUDED;;ETFB DEFICIENCY, INCLUDED;;GLUTARIC ACIDEMIA IIC, INCLUDED;;ETFDH DEFICIENCY, INCLUDED 1 P38117 438 2.51e-02 31 2 1 0.500 0.032 KEGG:00640 keg 1 Propanoate metabolism 1 P00338 438 3.07e-02 38 2 1 0.500 0.026 KEGG:00620 keg 1 Pyruvate metabolism 1 P00338 438 3.09e-02 405 2 2 1.000 0.005 MI:hsa-miR-943 mi 1 MI:hsa-miR-943 1 P38117,P00338 438 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 P38117,P00338 438 3.47e-02 43 2 1 0.500 0.023 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 P00338 438 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 P38117,P00338 438 4.10e-02 90 2 1 0.500 0.011 REAC:611105 rea 1 Respiratory electron transport 1 P38117 438 5.00e-02 110 2 1 0.500 0.009 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P38117 438 5.00e-02 3 2 1 0.500 0.333 HP:0003647 hp 1 Electron transfer flavoprotein-ubiquinone oxidoreductase defect 1 P38117 438 5.00e-02 3 2 1 0.500 0.333 HP:0003490 hp 1 Defective dehydrogenation of isovaleryl CoA and butyryl CoA 1 P38117 438 5.00e-02 7 2 1 0.500 0.143 OMIM:607426 omi 1 Primary Coenzyme Q10 Deficiency 1 P38117 438 5.00e-02 3 2 1 0.500 0.333 HP:0002614 hp 1 Hepatic periportal necrosis 1 P38117 438 5.00e-02 515 2 2 1.000 0.004 MI:hsa-miR-30a mi 1 MI:hsa-miR-30a 1 P38117,P00338 438 5.00e-02 3 2 1 0.500 0.333 HP:0004357 hp 1 Abnormality of leucine metabolism 1 P38117 438 5.00e-02 3 2 1 0.500 0.333 TF:M06775_1 tf 1 Factor: ZNF391; motif: NGGGTGAGGGTC; match class: 1 1 P38117 438 5.00e-02 572 2 2 1.000 0.003 GO:0044712 BP 1 single-organism catabolic process 1 P38117,P00338 438 5.00e-02 62 2 1 0.500 0.016 KEGG:00010 keg 1 Glycolysis / Gluconeogenesis 1 P00338 439 1.55e-02 68 1 1 1.000 0.015 GO:1903955 BP 1 positive regulation of protein targeting to mitochondrion 1 Q9H094 439 1.71e-02 75 1 1 1.000 0.013 GO:1903214 BP 1 regulation of protein targeting to mitochondrion 1 Q9H094 439 2.12e-02 93 1 1 1.000 0.011 GO:1903749 BP 1 positive regulation of establishment of protein localization to mitochondrion 1 Q9H094 439 2.31e-02 101 1 1 1.000 0.010 GO:1903747 BP 1 regulation of establishment of protein localization to mitochondrion 1 Q9H094 439 2.67e-02 117 1 1 1.000 0.009 GO:0006626 BP 1 protein targeting to mitochondrion 1 Q9H094 439 3.04e-02 133 1 1 1.000 0.008 GO:0010822 BP 1 positive regulation of mitochondrion organization 1 Q9H094 439 3.38e-02 148 1 1 1.000 0.007 GO:0072655 BP 1 establishment of protein localization to mitochondrion 1 Q9H094 439 3.42e-02 150 1 1 1.000 0.007 GO:0070585 BP 1 protein localization to mitochondrion 1 Q9H094 439 3.79e-02 166 1 1 1.000 0.006 GO:0090316 BP 1 positive regulation of intracellular protein transport 1 Q9H094 439 3.90e-02 171 1 1 1.000 0.006 GO:0010821 BP 1 regulation of mitochondrion organization 1 Q9H094 439 3.92e-02 416 1 1 1.000 0.002 MI:hsa-miR-134 mi 1 MI:hsa-miR-134 1 Q9H094 439 4.18e-02 183 1 1 1.000 0.005 GO:1903533 BP 1 regulation of protein targeting 1 Q9H094 439 4.32e-02 189 1 1 1.000 0.005 GO:0032388 BP 1 positive regulation of intracellular transport 1 Q9H094 439 4.76e-02 506 1 1 1.000 0.002 MI:hsa-miR-221 mi 1 MI:hsa-miR-221 1 Q9H094 439 5.00e-02 219 1 1 1.000 0.005 GO:0006839 BP 1 mitochondrial transport 1 Q9H094 439 5.00e-02 531 1 1 1.000 0.002 MI:hsa-miR-132 mi 1 MI:hsa-miR-132 1 Q9H094 439 5.00e-02 4 1 1 1.000 0.250 TF:M04175_0 tf 1 Factor: MAX; motif: CACGTGNNNNNCACGTG; match class: 0 1 Q9H094 439 5.00e-02 4 1 1 1.000 0.250 TF:M04175_1 tf 1 Factor: MAX; motif: CACGTGNNNNNCACGTG; match class: 1 1 Q9H094 440 6.71e-04 1 3 1 0.333 1.000 GO:0035607 BP 1 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060442 BP 1 branching involved in prostate gland morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060687 BP 1 regulation of branching involved in prostate gland morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060523 BP 1 prostate epithelial cord elongation 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060462 BP 1 lung lobe development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060449 BP 1 bud elongation involved in lung branching 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0021869 BP 1 forebrain ventricular zone progenitor cell division 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060463 BP 1 lung lobe morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0021847 BP 1 ventricular zone neuroblast division 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060664 BP 1 epithelial cell proliferation involved in salivary gland morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060648 BP 1 mammary gland bud morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0035604 BP 1 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060615 BP 1 mammary gland bud formation 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0035602 BP 1 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060527 BP 1 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060670 BP 1 branching involved in labyrinthine layer morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060526 BP 1 prostate glandular acinus morphogenesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060529 BP 1 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0035603 BP 1 fibroblast growth factor receptor signaling pathway involved in hemopoiesis 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0021769 BP 1 orbitofrontal cortex development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060484 BP 1 lung-associated mesenchyme development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060737 BP 1 prostate gland morphogenetic growth 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060915 BP 1 mesenchymal cell differentiation involved in lung development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060525 BP 1 prostate glandular acinus development 1 P21802 440 6.71e-04 1 3 1 0.333 1.000 GO:0060667 BP 1 branch elongation involved in salivary gland morphogenesis 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060740 BP 1 prostate gland epithelium morphogenesis 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060174 BP 1 limb bud formation 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071866 BP 1 negative regulation of apoptotic process in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0030916 BP 1 otic vesicle formation 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071838 BP 1 cell proliferation in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071863 BP 1 regulation of cell proliferation in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071600 BP 1 otic vesicle morphogenesis 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060572 BP 1 morphogenesis of an epithelial bud 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060601 BP 1 lateral sprouting from an epithelium 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0021860 BP 1 pyramidal neuron development 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071864 BP 1 positive regulation of cell proliferation in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060592 BP 1 mammary gland formation 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0021859 BP 1 pyramidal neuron differentiation 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060595 BP 1 fibroblast growth factor receptor signaling pathway involved in mammary gland specification 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060594 BP 1 mammary gland specification 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071839 BP 1 apoptotic process in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0071865 BP 1 regulation of apoptotic process in bone marrow 1 P21802 440 1.34e-03 2 3 1 0.333 0.500 GO:0060916 BP 1 mesenchymal cell proliferation involved in lung development 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0003149 BP 1 membranous septum morphogenesis 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060445 BP 1 branching involved in salivary gland morphogenesis 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060736 BP 1 prostate gland growth 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060603 BP 1 mammary gland duct morphogenesis 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060742 BP 1 epithelial cell differentiation involved in prostate gland development 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060501 BP 1 positive regulation of epithelial cell proliferation involved in lung morphogenesis 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0071599 BP 1 otic vesicle development 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060571 BP 1 morphogenesis of an epithelial fold 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0060512 BP 1 prostate gland morphogenesis 1 P21802 440 2.01e-03 3 3 1 0.333 0.333 GO:0032808 BP 1 lacrimal gland development 1 P21802 440 2.36e-03 10 3 1 0.333 0.100 TF:M06338_0 tf 1 Factor: ZNF813; motif: NGGTTGGGCAGA; match class: 0 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:2000794 BP 1 regulation of epithelial cell proliferation involved in lung morphogenesis 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:0007435 BP 1 salivary gland morphogenesis 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:0060713 BP 1 labyrinthine layer morphogenesis 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:0021873 BP 1 forebrain neuroblast division 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:0060669 BP 1 embryonic placenta morphogenesis 1 P21802 440 2.68e-03 4 3 1 0.333 0.250 GO:0060502 BP 1 epithelial cell proliferation involved in lung morphogenesis 1 P21802 440 3.25e-03 424 3 2 0.667 0.005 TF:M07398_0 tf 1 Factor: Brn-3b; motif: RCTCATTAAN; match class: 0 1 P21802,Q502X0 440 3.35e-03 5 3 1 0.333 0.200 GO:0060602 BP 1 branch elongation of an epithelium 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0031069 BP 1 hair follicle morphogenesis 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0007431 BP 1 salivary gland development 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0005007 MF 1 fibroblast growth factor-activated receptor activity 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0048730 BP 1 epidermis morphogenesis 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0060441 BP 1 epithelial tube branching involved in lung morphogenesis 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0060443 BP 1 mammary gland morphogenesis 1 P21802 440 3.35e-03 5 3 1 0.333 0.200 GO:0048755 BP 1 branching morphogenesis of a nerve 1 P21802 440 4.02e-03 6 3 1 0.333 0.167 GO:0048557 BP 1 embryonic digestive tract morphogenesis 1 P21802 440 4.69e-03 7 3 1 0.333 0.143 GO:0035272 BP 1 exocrine system development 1 P21802 440 4.69e-03 7 3 1 0.333 0.143 GO:0048286 BP 1 lung alveolus development 1 P21802 440 4.69e-03 7 3 1 0.333 0.143 GO:0030850 BP 1 prostate gland development 1 P21802 440 5.36e-03 8 3 1 0.333 0.125 GO:0021846 BP 1 cell proliferation in forebrain 1 P21802 440 5.36e-03 8 3 1 0.333 0.125 GO:0060711 BP 1 labyrinthine layer development 1 P21802 440 5.36e-03 8 3 1 0.333 0.125 GO:0010092 BP 1 specification of animal organ identity 1 P21802 440 5.36e-03 8 3 1 0.333 0.125 GO:0033688 BP 1 regulation of osteoblast proliferation 1 P21802 440 5.36e-03 8 3 1 0.333 0.125 GO:0003401 BP 1 axis elongation 1 P21802 440 5.88e-03 25 3 1 0.333 0.040 TF:M06029_0 tf 1 Factor: ZNF197; motif: NATACCAYCATA; match class: 0 1 Q502X0 440 6.03e-03 9 3 1 0.333 0.111 GO:0009791 BP 1 post-embryonic development 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0060076 CC 1 excitatory synapse 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0060428 BP 1 lung epithelium development 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0048546 BP 1 digestive tract morphogenesis 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0036445 BP 1 neuronal stem cell division 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0055057 BP 1 neuroblast division 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0010453 BP 1 regulation of cell fate commitment 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0002053 BP 1 positive regulation of mesenchymal cell proliferation 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0033687 BP 1 osteoblast proliferation 1 P21802 440 6.03e-03 9 3 1 0.333 0.111 GO:0060425 BP 1 lung morphogenesis 1 P21802 440 6.26e-03 1 3 1 0.333 1.000 REAC:8853333 rea 1 Signaling by FGFR2 fusions 1 P21802 440 6.26e-03 1 3 1 0.333 1.000 REAC:2023837 rea 1 Signaling by FGFR2 amplification mutants 1 P21802 440 6.70e-03 10 3 1 0.333 0.100 GO:0055023 BP 1 positive regulation of cardiac muscle tissue growth 1 P21802 440 6.70e-03 10 3 1 0.333 0.100 GO:0060045 BP 1 positive regulation of cardiac muscle cell proliferation 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0048103 BP 1 somatic stem cell division 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0040014 BP 1 regulation of multicellular organism growth 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0046622 BP 1 positive regulation of organ growth 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0040036 BP 1 regulation of fibroblast growth factor receptor signaling pathway 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0051150 BP 1 regulation of smooth muscle cell differentiation 1 P21802 440 7.37e-03 11 3 1 0.333 0.091 GO:0060421 BP 1 positive regulation of heart growth 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0035264 BP 1 multicellular organism growth 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0048566 BP 1 embryonic digestive tract development 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0021884 BP 1 forebrain neuron development 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0048701 BP 1 embryonic cranial skeleton morphogenesis 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0010464 BP 1 regulation of mesenchymal cell proliferation 1 P21802 440 8.04e-03 12 3 1 0.333 0.083 GO:0048645 BP 1 animal organ formation 1 P21802 440 8.71e-03 13 3 1 0.333 0.077 GO:0042472 BP 1 inner ear morphogenesis 1 P21802 440 8.71e-03 13 3 1 0.333 0.077 GO:0002067 BP 1 glandular epithelial cell differentiation 1 P21802 440 9.38e-03 14 3 1 0.333 0.071 GO:0055025 BP 1 positive regulation of cardiac muscle tissue development 1 P21802 440 9.38e-03 14 3 1 0.333 0.071 GO:0060043 BP 1 regulation of cardiac muscle cell proliferation 1 P21802 440 9.38e-03 14 3 1 0.333 0.071 GO:0010463 BP 1 mesenchymal cell proliferation 1 P21802 440 9.38e-03 14 3 1 0.333 0.071 GO:0003148 BP 1 outflow tract septum morphogenesis 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:609579 omi 1 SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:101200 omi 1 APERT SYNDROME;;ACROCEPHALOSYNDACTYLY, TYPE I; ACS1;;ACS IAPERT-CROUZON DISEASE, INCLUDED;;ACROCEPHALOSYNDACTYLY, TYPE II, INCLUDED;;ACS II, INCLUDED;;VOGT CEPHALODACTYLY, INCLUDED 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:614592 omi 1 BENT BONE DYSPLASIA SYNDROME; BBDS 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:101400 omi 1 SAETHRE-CHOTZEN SYNDROME; SCS;;ACROCEPHALOSYNDACTYLY, TYPE III; ACS3;;ACS III;;CHOTZEN SYNDROME;;ACROCEPHALY, SKULL ASYMMETRY, AND MILD SYNDACTYLYSAETHRE-CHOTZEN SYNDROME WITH EYELID ANOMALIES, INCLUDED;;BLEPHAROPHIMOSIS, EPICANTHUS INVERSUS, AND PTOSIS 3, FORMERLY, INCLUDED;BPES3, FORMERLY, INCLUDED 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:123790 omi 1 BEARE-STEVENSON CUTIS GYRATA SYNDROME; BSTVS;;BEARE-STEVENSON SYNDROME;;CUTIS GYRATA SYNDROME OF BEARE AND STEVENSON 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:123500 omi 1 CROUZON SYNDROME;;CRANIOFACIAL DYSOSTOSIS, TYPE I; CFD1;;CROUZON CRANIOFACIAL DYSOSTOSIS 1 P21802 440 1.00e-02 1 3 1 0.333 1.000 OMIM:207410 omi 1 ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESIS;ABS2;;TRAPEZOIDOCEPHALY-SYNOSTOSIS SYNDROME;;MULTISYNOSTOTIC OSTEODYSGENESIS WITH LONG BONE FRACTURES;;OSTEODYSGENESIS, MULTISYNOSTOTIC, WITH FRACTURES 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0060688 BP 1 regulation of morphogenesis of a branching structure 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0022405 BP 1 hair cycle process 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0022612 BP 1 gland morphogenesis 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0022404 BP 1 molting cycle process 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0001942 BP 1 hair follicle development 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0017145 BP 1 stem cell division 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0098773 BP 1 skin epidermis development 1 P21802 440 1.01e-02 15 3 1 0.333 0.067 GO:0055021 BP 1 regulation of cardiac muscle tissue growth 1 P21802 440 1.07e-02 16 3 1 0.333 0.062 GO:1904888 BP 1 cranial skeletal system development 1 P21802 440 1.07e-02 16 3 1 0.333 0.062 GO:0042471 BP 1 ear morphogenesis 1 P21802 440 1.07e-02 16 3 1 0.333 0.062 GO:0060412 BP 1 ventricular septum morphogenesis 1 P21802 440 1.07e-02 16 3 1 0.333 0.062 GO:0060038 BP 1 cardiac muscle cell proliferation 1 P21802 440 1.14e-02 17 3 1 0.333 0.059 GO:0060420 BP 1 regulation of heart growth 1 P21802 440 1.14e-02 17 3 1 0.333 0.059 GO:0001892 BP 1 embryonic placenta development 1 P21802 440 1.14e-02 17 3 1 0.333 0.059 GO:0060349 BP 1 bone morphogenesis 1 P21802 440 1.14e-02 17 3 1 0.333 0.059 GO:0009880 BP 1 embryonic pattern specification 1 P21802 440 1.14e-02 17 3 1 0.333 0.059 GO:0017134 MF 1 fibroblast growth factor binding 1 P21802 440 1.15e-02 49 3 1 0.333 0.020 TF:M03789_1 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 1 1 Q6P047 440 1.21e-02 18 3 1 0.333 0.056 GO:0003281 BP 1 ventricular septum development 1 P21802 440 1.21e-02 18 3 1 0.333 0.056 GO:0021761 BP 1 limbic system development 1 P21802 440 1.21e-02 18 3 1 0.333 0.056 GO:0061180 BP 1 mammary gland epithelium development 1 P21802 440 1.22e-02 52 3 1 0.333 0.019 TF:M06656_0 tf 1 Factor: ZNF436; motif: NTGGTGGGCGGA; match class: 0 1 Q6P047 440 1.27e-02 54 3 1 0.333 0.019 TF:M01023_0 tf 1 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 0 1 Q6P047 440 1.27e-02 19 3 1 0.333 0.053 GO:0055017 BP 1 cardiac muscle tissue growth 1 P21802 440 1.27e-02 19 3 1 0.333 0.053 GO:0008589 BP 1 regulation of smoothened signaling pathway 1 P21802 440 1.27e-02 19 3 1 0.333 0.053 GO:0021879 BP 1 forebrain neuron differentiation 1 P21802 440 1.27e-02 19 3 1 0.333 0.053 GO:0051145 BP 1 smooth muscle cell differentiation 1 P21802 440 1.31e-02 56 3 1 0.333 0.018 TF:M00447_1 tf 1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 1 Q502X0 440 1.34e-02 20 3 1 0.333 0.050 GO:0048704 BP 1 embryonic skeletal system morphogenesis 1 P21802 440 1.38e-02 59 3 1 0.333 0.017 TF:M05523_0 tf 1 Factor: ZBTB46; motif: NGGGGGATAGN; match class: 0 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0021872 BP 1 forebrain generation of neurons 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0060419 BP 1 heart growth 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0048839 BP 1 inner ear development 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0001657 BP 1 ureteric bud development 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0014855 BP 1 striated muscle cell proliferation 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0042303 BP 1 molting cycle 1 P21802 440 1.41e-02 21 3 1 0.333 0.048 GO:0042633 BP 1 hair cycle 1 P21802 440 1.45e-02 62 3 1 0.333 0.016 TF:M06525_0 tf 1 Factor: ZNF431; motif: NGKTWGGGCAGA; match class: 0 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:0048636 BP 1 positive regulation of muscle organ development 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:0072164 BP 1 mesonephric tubule development 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:1901863 BP 1 positive regulation of muscle tissue development 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:0045844 BP 1 positive regulation of striated muscle tissue development 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:0072163 BP 1 mesonephric epithelium development 1 P21802 440 1.47e-02 22 3 1 0.333 0.045 GO:0007405 BP 1 neuroblast proliferation 1 P21802 440 1.50e-02 64 3 1 0.333 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 Q502X0 440 1.54e-02 23 3 1 0.333 0.043 GO:0055024 BP 1 regulation of cardiac muscle tissue development 1 P21802 440 1.54e-02 23 3 1 0.333 0.043 GO:0021954 BP 1 central nervous system neuron development 1 P21802 440 1.61e-02 24 3 1 0.333 0.042 GO:0002065 BP 1 columnar/cuboidal epithelial cell differentiation 1 P21802 440 1.61e-02 24 3 1 0.333 0.042 GO:0001823 BP 1 mesonephros development 1 P21802 440 1.67e-02 25 3 1 0.333 0.040 GO:0055010 BP 1 ventricular cardiac muscle tissue morphogenesis 1 P21802 440 1.67e-02 25 3 1 0.333 0.040 GO:0046620 BP 1 regulation of organ growth 1 P21802 440 1.68e-02 3258 3 3 1.000 0.001 TF:M03568_0 tf 1 Factor: TR4; motif: STGACCTTT; match class: 0 1 P21802,Q6P047,Q502X0 440 1.74e-02 26 3 1 0.333 0.038 GO:0001890 BP 1 placenta development 1 P21802 440 1.74e-02 26 3 1 0.333 0.038 GO:0003229 BP 1 ventricular cardiac muscle tissue development 1 P21802 440 1.74e-02 26 3 1 0.333 0.038 GO:2000241 BP 1 regulation of reproductive process 1 P21802 440 1.74e-02 26 3 1 0.333 0.038 GO:0060411 BP 1 cardiac septum morphogenesis 1 P21802 440 1.74e-02 26 3 1 0.333 0.038 GO:0043583 BP 1 ear development 1 P21802 440 1.75e-02 1000 3 2 0.667 0.002 TF:M01241_0 tf 1 Factor: BEN; motif: CWGCGAYA; match class: 0 1 P21802,Q6P047 440 1.81e-02 27 3 1 0.333 0.037 GO:0048706 BP 1 embryonic skeletal system development 1 P21802 440 1.85e-02 79 3 1 0.333 0.013 TF:M00105_0 tf 1 Factor: CDP; motif: CACCRATANNTATBG; match class: 0 1 Q502X0 440 1.87e-02 28 3 1 0.333 0.036 GO:0030879 BP 1 mammary gland development 1 P21802 440 1.87e-02 28 3 1 0.333 0.036 GO:0030324 BP 1 lung development 1 P21802 440 1.87e-02 28 3 1 0.333 0.036 GO:0010518 BP 1 positive regulation of phospholipase activity 1 P21802 440 1.94e-02 29 3 1 0.333 0.034 GO:0051781 BP 1 positive regulation of cell division 1 P21802 440 1.94e-02 29 3 1 0.333 0.034 GO:0042476 BP 1 odontogenesis 1 P21802 440 1.99e-02 1066 3 2 0.667 0.002 TF:M02106_0 tf 1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 0 1 P21802,Q502X0 440 1.99e-02 85 3 1 0.333 0.012 TF:M05660_0 tf 1 Factor: ZNF286B; motif: NTTGGCGGATGM; match class: 0 1 Q6P047 440 2.00e-02 2 3 1 0.333 0.500 OMIM:123150 omi 1 JACKSON-WEISS SYNDROME; JWS;;CRANIOSYNOSTOSIS, MIDFACIAL HYPOPLASIA, AND FOOT ABNORMALITIES 1 P21802 440 2.00e-02 2 3 1 0.333 0.500 OMIM:101600 omi 1 PFEIFFER SYNDROME;;ACROCEPHALOSYNDACTYLY, TYPE V; ACS5;;ACS V;;NOACK SYNDROMECRANIOFACIAL-SKELETAL-DERMATOLOGIC DYSPLASIA, INCLUDED 1 P21802 440 2.01e-02 30 3 1 0.333 0.033 GO:0035107 BP 1 appendage morphogenesis 1 P21802 440 2.01e-02 30 3 1 0.333 0.033 GO:0030323 BP 1 respiratory tube development 1 P21802 440 2.01e-02 30 3 1 0.333 0.033 GO:0016303 MF 1 1-phosphatidylinositol-3-kinase activity 1 P21802 440 2.01e-02 30 3 1 0.333 0.033 GO:0055008 BP 1 cardiac muscle tissue morphogenesis 1 P21802 440 2.01e-02 30 3 1 0.333 0.033 GO:0035108 BP 1 limb morphogenesis 1 P21802 440 2.14e-02 32 3 1 0.333 0.031 GO:0003151 BP 1 outflow tract morphogenesis 1 P21802 440 2.14e-02 32 3 1 0.333 0.031 GO:0003279 BP 1 cardiac septum development 1 P21802 440 2.15e-02 92 3 1 0.333 0.011 TF:M05620_0 tf 1 Factor: HKR1; motif: NRTGAAAAAAGA; match class: 0 1 P21802 440 2.21e-02 33 3 1 0.333 0.030 GO:0048644 BP 1 muscle organ morphogenesis 1 P21802 440 2.21e-02 33 3 1 0.333 0.030 GO:0048565 BP 1 digestive tract development 1 P21802 440 2.21e-02 33 3 1 0.333 0.030 GO:0060415 BP 1 muscle tissue morphogenesis 1 P21802 440 2.21e-02 33 3 1 0.333 0.030 GO:0055123 BP 1 digestive system development 1 P21802 440 2.27e-02 34 3 1 0.333 0.029 GO:0060193 BP 1 positive regulation of lipase activity 1 P21802 440 2.29e-02 98 3 1 0.333 0.010 TF:M07233_1 tf 1 Factor: USF1; motif: NNCAYGTGACC; match class: 1 1 Q6P047 440 2.32e-02 99 3 1 0.333 0.010 TF:M01236_0 tf 1 Factor: ipf1; motif: CATTAATMGG; match class: 0 1 P21802 440 2.34e-02 35 3 1 0.333 0.029 GO:0052742 MF 1 phosphatidylinositol kinase activity 1 P21802 440 2.34e-02 35 3 1 0.333 0.029 GO:0010517 BP 1 regulation of phospholipase activity 1 P21802 440 2.41e-02 36 3 1 0.333 0.028 GO:0048754 BP 1 branching morphogenesis of an epithelial tube 1 P21802 440 2.47e-02 37 3 1 0.333 0.027 GO:0035265 BP 1 organ growth 1 P21802 440 2.47e-02 37 3 1 0.333 0.027 GO:0060541 BP 1 respiratory system development 1 P21802 440 2.47e-02 37 3 1 0.333 0.027 GO:0003208 BP 1 cardiac ventricle morphogenesis 1 P21802 440 2.50e-02 1 3 1 0.333 1.000 HP:0007343 hp 1 Limbic malformations 1 P21802 440 2.50e-02 1 3 1 0.333 1.000 HP:0004450 hp 1 Preauricular skin furrow 1 P21802 440 2.50e-02 1 3 1 0.333 1.000 HP:0003246 hp 1 Prominent scrotal raphe 1 P21802 440 2.50e-02 1 3 1 0.333 1.000 HP:0004487 hp 1 Acrobrachycephaly 1 P21802 440 2.54e-02 38 3 1 0.333 0.026 GO:0001701 BP 1 in utero embryonic development 1 P21802 440 2.54e-02 38 3 1 0.333 0.026 GO:0016331 BP 1 morphogenesis of embryonic epithelium 1 P21802 440 2.59e-02 111 3 1 0.333 0.009 TF:M06003_0 tf 1 Factor: ZNF257; motif: NTGGWGGGCAKM; match class: 0 1 Q6P047 440 2.60e-02 1225 3 2 0.667 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 P21802,Q502X0 440 2.61e-02 39 3 1 0.333 0.026 GO:0061138 BP 1 morphogenesis of a branching epithelium 1 P21802 440 2.61e-02 39 3 1 0.333 0.026 GO:0007224 BP 1 smoothened signaling pathway 1 P21802 440 2.61e-02 39 3 1 0.333 0.026 GO:0046934 MF 1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1 P21802 440 2.64e-02 113 3 1 0.333 0.009 TF:M06444_1 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 1 1 P21802 440 2.67e-02 40 3 1 0.333 0.025 GO:0060173 BP 1 limb development 1 P21802 440 2.67e-02 40 3 1 0.333 0.025 GO:0048736 BP 1 appendage development 1 P21802 440 2.67e-02 40 3 1 0.333 0.025 GO:0072073 BP 1 kidney epithelium development 1 P21802 440 2.71e-02 116 3 1 0.333 0.009 TF:M05781_0 tf 1 Factor: ZNF699; motif: NTGTCGGGCAGM; match class: 0 1 Q6P047 440 2.81e-02 42 3 1 0.333 0.024 GO:0048705 BP 1 skeletal system morphogenesis 1 P21802 440 2.81e-02 42 3 1 0.333 0.024 GO:0060348 BP 1 bone development 1 P21802 440 2.81e-02 42 3 1 0.333 0.024 GO:0052813 MF 1 phosphatidylinositol bisphosphate kinase activity 1 P21802 440 2.94e-02 44 3 1 0.333 0.023 GO:0060191 BP 1 regulation of lipase activity 1 P21802 440 2.94e-02 44 3 1 0.333 0.023 GO:0061351 BP 1 neural precursor cell proliferation 1 P21802 440 2.99e-02 1317 3 2 0.667 0.002 TF:M01208_0 tf 1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 0 1 Q6P047,Q502X0 440 3.00e-02 3 3 1 0.333 0.333 OMIM:149730 omi 1 LACRIMOAURICULODENTODIGITAL SYNDROME; LADD;;LEVY-HOLLISTER SYNDROME 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:0001763 BP 1 morphogenesis of a branching structure 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:1901861 BP 1 regulation of muscle tissue development 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:0016202 BP 1 regulation of striated muscle tissue development 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:0072089 BP 1 stem cell proliferation 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:0003231 BP 1 cardiac ventricle development 1 P21802 440 3.01e-02 45 3 1 0.333 0.022 GO:0045667 BP 1 regulation of osteoblast differentiation 1 P21802 440 3.07e-02 46 3 1 0.333 0.022 GO:0004714 MF 1 transmembrane receptor protein tyrosine kinase activity 1 P21802 440 3.07e-02 46 3 1 0.333 0.022 GO:0030282 BP 1 bone mineralization 1 P21802 440 3.07e-02 46 3 1 0.333 0.022 GO:0035004 MF 1 phosphatidylinositol 3-kinase activity 1 P21802 440 3.07e-02 46 3 1 0.333 0.022 GO:0048634 BP 1 regulation of muscle organ development 1 P21802 440 3.08e-02 1338 3 2 0.667 0.001 TF:M06444_0 tf 1 Factor: ZNF557; motif: NCCGCKTCCTGC; match class: 0 1 P21802,Q502X0 440 3.13e-02 5 3 1 0.333 0.200 REAC:190375 rea 1 FGFR2c ligand binding and activation 1 P21802 440 3.15e-02 135 3 1 0.333 0.007 TF:M01224_1 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 1 P21802 440 3.18e-02 1361 3 2 0.667 0.001 TF:M01661_0 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 0 1 Q6P047,Q502X0 440 3.21e-02 48 3 1 0.333 0.021 GO:0003206 BP 1 cardiac chamber morphogenesis 1 P21802 440 3.27e-02 4069 3 3 1.000 0.001 TF:M00773_0 tf 1 Factor: c-MYB; motif: NNNGNCAGTTN; match class: 0 1 P21802,Q6P047,Q502X0 440 3.27e-02 49 3 1 0.333 0.020 GO:0048639 BP 1 positive regulation of developmental growth 1 P21802 440 3.29e-02 4080 3 3 1.000 0.001 TF:M01173_1 tf 1 Factor: SREBP-1; motif: NSNNTCACNCCANNN; match class: 1 1 P21802,Q6P047,Q502X0 440 3.41e-02 51 3 1 0.333 0.020 GO:0031214 BP 1 biomineral tissue development 1 P21802 440 3.41e-02 51 3 1 0.333 0.020 GO:0021953 BP 1 central nervous system neuron differentiation 1 P21802 440 3.41e-02 51 3 1 0.333 0.020 GO:0030901 BP 1 midbrain development 1 P21802 440 3.52e-02 151 3 1 0.333 0.007 TF:M04619_1 tf 1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 1 P21802 440 3.61e-02 4206 3 3 1.000 0.001 TF:M01243_1 tf 1 Factor: MTF-1; motif: TGCGCAC; match class: 1 1 P21802,Q6P047,Q502X0 440 3.67e-02 55 3 1 0.333 0.018 GO:0003205 BP 1 cardiac chamber development 1 P21802 440 3.71e-02 1473 3 2 0.667 0.001 TF:M01142_0 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 0 1 P21802,Q502X0 440 3.74e-02 56 3 1 0.333 0.018 GO:0033002 BP 1 muscle cell proliferation 1 P21802 440 3.75e-02 6 3 1 0.333 0.167 REAC:190377 rea 1 FGFR2b ligand binding and activation 1 P21802 440 3.76e-02 4263 3 3 1.000 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 P21802,Q6P047,Q502X0 440 3.87e-02 58 3 1 0.333 0.017 GO:0090596 BP 1 sensory organ morphogenesis 1 P21802 440 3.94e-02 59 3 1 0.333 0.017 GO:0050679 BP 1 positive regulation of epithelial cell proliferation 1 P21802 440 4.01e-02 60 3 1 0.333 0.017 GO:0019199 MF 1 transmembrane receptor protein kinase activity 1 P21802 440 4.14e-02 178 3 1 0.333 0.006 TF:M07100_0 tf 1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 0 1 Q6P047 440 4.14e-02 62 3 1 0.333 0.016 GO:0051302 BP 1 regulation of cell division 1 P21802 440 4.39e-02 64 3 1 0.333 0.016 KEGG:05230 keg 1 Central carbon metabolism in cancer 1 P21802 440 4.46e-02 192 3 1 0.333 0.005 TF:M04012_1 tf 1 Factor: HSFY1; motif: TTTCGAACG; match class: 1 1 Q502X0 440 4.54e-02 68 3 1 0.333 0.015 GO:0048562 BP 1 embryonic organ morphogenesis 1 P21802 440 4.60e-02 69 3 1 0.333 0.014 GO:0008543 BP 1 fibroblast growth factor receptor signaling pathway 1 P21802 440 4.60e-02 69 3 1 0.333 0.014 GO:0030278 BP 1 regulation of ossification 1 P21802 440 4.65e-02 445 3 3 1.000 0.007 MI:hsa-miR-556-5p mi 1 MI:hsa-miR-556-5p 1 P21802,Q6P047,Q502X0 440 4.65e-02 1658 3 2 0.667 0.001 TF:M03867_1 tf 1 Factor: c-Myc; motif: CACGTGGC; match class: 1 1 Q6P047,Q502X0 440 4.67e-02 70 3 1 0.333 0.014 GO:0048863 BP 1 stem cell differentiation 1 P21802 440 4.71e-02 203 3 1 0.333 0.005 TF:M01233_1 tf 1 Factor: ipf1; motif: MVCTAATTAS; match class: 1 1 Q502X0 440 4.73e-02 71 3 1 0.333 0.014 GO:0048738 BP 1 cardiac muscle tissue development 1 P21802 440 4.79e-02 4622 3 3 1.000 0.001 TF:M01168_1 tf 1 Factor: SREBP; motif: NNNNYCACNCCANNN; match class: 1 1 P21802,Q6P047,Q502X0 440 4.81e-02 1688 3 2 0.667 0.001 TF:M07426_0 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 0 1 P21802,Q6P047 440 4.82e-02 208 3 1 0.333 0.005 TF:M06849_0 tf 1 Factor: ZNF528; motif: NSTCCGGAAGA; match class: 0 1 Q502X0 440 4.87e-02 73 3 1 0.333 0.014 GO:0051147 BP 1 regulation of muscle cell differentiation 1 P21802 440 4.87e-02 73 3 1 0.333 0.014 GO:0045165 BP 1 cell fate commitment 1 P21802 440 4.87e-02 73 3 1 0.333 0.014 GO:0003002 BP 1 regionalization 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009968 hp 1 Partial duplication of the distal phalanx of the 3rd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0004468 hp 1 Anomalous tracheal cartilage 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0010104 hp 1 Absent first metatarsal 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009951 hp 1 Partial duplication of the distal phalanx of the 2nd finger 1 P21802 440 5.00e-02 75 3 1 0.333 0.013 GO:0019838 MF 1 growth factor binding 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009958 hp 1 Polydactyly affecting the 3rd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009895 hp 1 Abnormality of the crus of the helix 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009946 hp 1 Polydactyly affecting the 2nd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009961 hp 1 Partial duplication of the phalanges of the 3rd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009948 hp 1 Duplication of the distal phalanx of the 2nd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0008111 hp 1 Broad distal hallux 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0008122 hp 1 Calcaneonavicular fusion 1 P21802 440 5.00e-02 456 3 3 1.000 0.007 MI:hsa-miR-886-3p mi 1 MI:hsa-miR-886-3p 1 P21802,Q6P047,Q502X0 440 5.00e-02 2 3 1 0.333 0.500 HP:0009959 hp 1 Duplication of phalanx of 3rd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009962 hp 1 Duplication of the distal phalanx of the 3rd finger 1 P21802 440 5.00e-02 4 3 1 0.333 0.250 CORUM:2563 cor 1 FGFR2-c-Cbl-Lyn-Fyn complex 1 P21802 440 5.00e-02 8 3 1 0.333 0.125 REAC:190241 rea 1 FGFR2 ligand binding and activation 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009956 hp 1 Partial duplication of the phalanges of the 2nd finger 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0005347 hp 1 Cartilaginous trachea 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009945 hp 1 Duplication of phalanx of 2nd finger 1 P21802 440 5.00e-02 8 3 1 0.333 0.125 REAC:2033519 rea 1 Activated point mutants of FGFR2 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0009899 hp 1 Prominent crus of helix 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0010067 hp 1 Aplasia/hypoplasia of the 1st metatarsal 1 P21802 440 5.00e-02 2 3 1 0.333 0.500 HP:0011323 hp 1 Cleft of chin 1 P21802 441 2.12e-03 9 3 1 0.333 0.111 TF:M05597_0 tf 1 Factor: ZNF174; motif: KGTAAAGCGGA; match class: 0 1 Q9Y4P1 441 2.64e-03 336 3 2 0.667 0.006 MI:hsa-miR-508-5p mi 1 MI:hsa-miR-508-5p 1 Q9UNA3,Q8TC84 441 3.77e-03 16 3 1 0.333 0.062 TF:M00185_1 tf 1 Factor: NF-Y; motif: TRRCCAATSRN; match class: 1 1 Q9UNA3 441 4.47e-03 19 3 1 0.333 0.053 TF:M06749_0 tf 1 Factor: ZNF222; motif: NCGTAWTTCCGA; match class: 0 1 Q9Y4P1 441 5.08e-03 468 3 2 0.667 0.004 MI:hsa-miR-339-3p mi 1 MI:hsa-miR-339-3p 1 Q9Y4P1,Q8TC84 441 6.45e-03 2370 3 3 1.000 0.001 TF:M04624_0 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 0 1 Q9UNA3,Q9Y4P1,Q8TC84 441 7.52e-03 32 3 1 0.333 0.031 TF:M06679_0 tf 1 Factor: ZNF251; motif: KATAAGACGA; match class: 0 1 Q8TC84 441 7.67e-03 2511 3 3 1.000 0.001 TF:M00104_0 tf 1 Factor: CDP; motif: NATCGATCGS; match class: 0 1 Q9UNA3,Q9Y4P1,Q8TC84 441 7.99e-03 34 3 1 0.333 0.029 TF:M06214_0 tf 1 Factor: ZNF33b; motif: GTWAAGCGGA; match class: 0 1 Q9Y4P1 441 8.23e-03 35 3 1 0.333 0.029 TF:M05525_0 tf 1 Factor: ZBTB41; motif: TGGGCCCCCGA; match class: 0 1 Q9Y4P1 441 8.71e-03 2620 3 3 1.000 0.001 TF:M04430_0 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 0 1 Q9UNA3,Q9Y4P1,Q8TC84 441 1.06e-02 45 3 1 0.333 0.022 TF:M07234_1 tf 1 Factor: YY1; motif: CAARATGGCNGC; match class: 1 1 Q9Y4P1 441 1.15e-02 2875 3 3 1.000 0.001 TF:M03788_0 tf 1 Factor: CAR_RXR; motif: CYNNNNTGAMCTYW; match class: 0 1 Q9UNA3,Q9Y4P1,Q8TC84 441 1.64e-02 70 3 1 0.333 0.014 TF:M06184_0 tf 1 Factor: ZNF85; motif: NGGGATGGAAGM; match class: 0 1 Q9Y4P1 441 1.78e-02 76 3 1 0.333 0.013 TF:M01149_1 tf 1 Factor: DMRT4; motif: AATGTADCAAWTT; match class: 1 1 Q8TC84 441 1.83e-02 78 3 1 0.333 0.013 TF:M01261_1 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 1 1 Q8TC84 441 2.41e-02 103 3 1 0.333 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 Q8TC84 441 3.12e-02 41 3 1 0.333 0.024 REAC:913709 rea 1 O-linked glycosylation of mucins 1 Q9UNA3 441 3.13e-02 134 3 1 0.333 0.007 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q8TC84 441 3.25e-02 4062 3 3 1.000 0.001 TF:M04288_0 tf 1 Factor: BARHL2; motif: NNTAATTGNN; match class: 0 1 Q9UNA3,Q9Y4P1,Q8TC84 441 3.32e-02 1392 3 2 0.667 0.001 TF:M04315_1 tf 1 Factor: EMX2; motif: TAATTARNTAATKA; match class: 1 1 Q9UNA3,Q9Y4P1 441 3.49e-02 150 3 1 0.333 0.007 TF:M00292_1 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 1 1 Q8TC84 441 3.63e-02 156 3 1 0.333 0.006 TF:M01147_0 tf 1 Factor: DMRT2; motif: NAWWTTGWTACATTGW; match class: 0 1 Q8TC84 441 3.70e-02 159 3 1 0.333 0.006 TF:M06705_0 tf 1 Factor: PRDM9; motif: NRGGCAGTRGGA; match class: 0 1 Q8TC84 441 3.79e-02 163 3 1 0.333 0.006 TF:M06513_0 tf 1 Factor: ZFP90; motif: NSGTTKGGCMGM; match class: 0 1 Q8TC84 441 3.87e-02 1507 3 2 0.667 0.001 TF:M07325_1 tf 1 Factor: MaFA; motif: TCTGCTGASCNN; match class: 1 1 Q9Y4P1,Q8TC84 441 3.95e-02 170 3 1 0.333 0.006 TF:M06871_0 tf 1 Factor: ZNF224; motif: NAATGCYAATCY; match class: 0 1 Q8TC84 441 4.07e-02 175 3 1 0.333 0.006 TF:M01058_1 tf 1 Factor: Gfi1b; motif: TAAATCACTGCW; match class: 1 1 Q9UNA3 441 4.48e-02 1626 3 2 0.667 0.001 TF:M06119_0 tf 1 Factor: ZNF254; motif: NAGGAAARTATM; match class: 0 1 Q9UNA3,Q8TC84 441 4.84e-02 1693 3 2 0.667 0.001 TF:M01826_0 tf 1 Factor: PITX1; motif: GMMACTAATCY; match class: 0 1 Q9UNA3,Q8TC84 441 4.91e-02 212 3 1 0.333 0.005 TF:M05770_0 tf 1 Factor: ZNFpT1; motif: GTWTTTTCGA; match class: 0 1 Q8TC84 441 4.98e-02 215 3 1 0.333 0.005 TF:M07082_0 tf 1 Factor: DUX4; motif: TAAYYYAATCA; match class: 0 1 Q8TC84 441 5.00e-02 4 3 1 0.333 0.250 GO:0051697 BP 1 protein delipidation 1 Q9Y4P1 441 5.00e-02 66 3 1 0.333 0.015 REAC:1632852 rea 1 Macroautophagy 1 Q9Y4P1 441 5.00e-02 31 3 1 0.333 0.032 KEGG:04140 keg 1 Autophagy 1 Q9Y4P1 442 2.26e-03 1076 4 3 0.750 0.003 TF:M00623_1 tf 1 Factor: Crx; motif: YNNNTAATCYSMN; match class: 1 1 Q13107,Q8N1I0,Q8TD17 442 2.75e-03 277 4 2 0.500 0.007 TF:M06777_0 tf 1 Factor: ZNF214; motif: NGKTCATAGAGA; match class: 0 1 Q8N1I0,Q8TD17 442 2.83e-03 9 4 1 0.250 0.111 TF:M06401_0 tf 1 Factor: ZNF551; motif: KGGTCCTAAATM; match class: 0 1 Q13107 442 3.53e-03 3103 4 4 1.000 0.001 TF:M02075_0 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 4.29e-03 3258 4 4 1.000 0.001 TF:M03568_0 tf 1 Factor: TR4; motif: STGACCTTT; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 6.27e-03 20 4 1 0.250 0.050 TF:M06488_0 tf 1 Factor: ZNF595; motif: NGGGAGGGMWTC; match class: 0 1 Q92556 442 8.77e-03 28 4 1 0.250 0.036 TF:M05869_0 tf 1 Factor: ZNF454; motif: NTGGYTKAAATC; match class: 0 1 Q8TD17 442 1.12e-02 568 4 2 0.500 0.004 TF:M03948_0 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 0 1 Q8N1I0,Q92556 442 1.35e-02 624 4 2 0.500 0.003 TF:M04343_1 tf 1 Factor: HOXA1; motif: NNYAATTANN; match class: 1 1 Q8N1I0,Q92556 442 1.41e-02 45 4 1 0.250 0.022 TF:M00228_1 tf 1 Factor: VBP; motif: GTTACRTMAT; match class: 1 1 Q92556 442 1.50e-02 48 4 1 0.250 0.021 TF:M05920_0 tf 1 Factor: ZNF556; motif: NGATCCGGTMGA; match class: 0 1 Q8TD17 442 1.50e-02 48 4 1 0.250 0.021 TF:M05921_0 tf 1 Factor: ZFP14; motif: KGGTGAAAAATA; match class: 0 1 Q8N1I0 442 1.56e-02 672 4 2 0.500 0.003 TF:M07207_0 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 0 1 Q92556,Q8TD17 442 1.61e-02 8 4 1 0.250 0.125 REAC:164944 rea 1 Nef and signal transduction 1 Q92556 442 1.62e-02 52 4 1 0.250 0.019 TF:M06656_0 tf 1 Factor: ZNF436; motif: NTGGTGGGCGGA; match class: 0 1 Q8TD17 442 1.78e-02 57 4 1 0.250 0.018 TF:M04225_1 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 1 1 Q92556 442 2.00e-02 2 4 1 0.250 0.500 GO:0031685 MF 1 adenosine receptor binding 1 Q13107 442 2.00e-02 2 4 1 0.250 0.500 GO:1904694 BP 1 negative regulation of vascular smooth muscle contraction 1 Q8N1I0 442 2.00e-02 2 4 1 0.250 0.500 GO:0003056 BP 1 regulation of vascular smooth muscle contraction 1 Q8N1I0 442 2.01e-02 10 4 1 0.250 0.100 REAC:5357786 rea 1 TNFR1-induced proapoptotic signaling 1 Q13107 442 2.08e-02 4836 4 4 1.000 0.001 TF:M07416_0 tf 1 Factor: Cdx-2; motif: NNNNNWTTTATNNN; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 2.09e-02 67 4 1 0.250 0.015 TF:M06624_0 tf 1 Factor: ZNF2; motif: NSATCGATCCGA; match class: 0 1 Q8N1I0 442 2.28e-02 4949 4 4 1.000 0.001 TF:M00289_0 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 2.40e-02 77 4 1 0.250 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 Q92556 442 2.40e-02 77 4 1 0.250 0.013 TF:M06650_0 tf 1 Factor: znf670; motif: NNTGTRACCCGN; match class: 0 1 Q8N1I0 442 2.47e-02 5047 4 4 1.000 0.001 TF:M05467_0 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 2.48e-02 5054 4 4 1.000 0.001 TF:M01659_0 tf 1 Factor: Cdx-2; motif: BNNATAAANRN; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 2.62e-02 5123 4 4 1.000 0.001 TF:M03925_0 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 2.89e-02 93 4 1 0.250 0.011 TF:M00260_1 tf 1 Factor: HLF; motif: GTTACRYAAT; match class: 1 1 Q92556 442 2.90e-02 2605 4 3 0.750 0.001 TF:M03932_0 tf 1 Factor: ZIC4; motif: GRCCCCCCGCNGNGN; match class: 0 1 Q8N1I0,Q92556,Q8TD17 442 2.94e-02 2617 4 3 0.750 0.001 TF:M03547_1 tf 1 Factor: ER-alpha; motif: TGACCYN; match class: 1 1 Q8N1I0,Q92556,Q8TD17 442 2.99e-02 946 4 2 0.500 0.002 TF:M00729_1 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 1 1 Q13107,Q8TD17 442 3.00e-02 3 4 1 0.250 0.333 GO:0045986 BP 1 negative regulation of smooth muscle contraction 1 Q8N1I0 442 3.04e-02 98 4 1 0.250 0.010 TF:M07050_1 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 1 1 Q92556 442 3.26e-02 105 4 1 0.250 0.010 TF:M07415_0 tf 1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 0 1 Q8N1I0 442 3.26e-02 105 4 1 0.250 0.010 TF:M03984_0 tf 1 Factor: ETV6; motif: CCGGAASCGGAAGTR; match class: 0 1 Q8TD17 442 3.29e-02 106 4 1 0.250 0.009 TF:M05958_0 tf 1 Factor: ZNF286; motif: NTTGGCGGATGM; match class: 0 1 Q8N1I0 442 3.38e-02 109 4 1 0.250 0.009 TF:M03934_0 tf 1 Factor: ZBTB18; motif: NATCCAGATGTKN; match class: 0 1 Q8N1I0 442 3.44e-02 111 4 1 0.250 0.009 TF:M04000_0 tf 1 Factor: GCM1; motif: ATRCKGGTRCCMGCAN; match class: 0 1 Q92556 442 3.47e-02 5496 4 4 1.000 0.001 TF:M02110_0 tf 1 Factor: NR1B1; motif: ANAGGTCANN; match class: 0 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 3.63e-02 117 4 1 0.250 0.009 TF:M06285_0 tf 1 Factor: ZNF124; motif: NGGTACTTGGGA; match class: 0 1 Q13107 442 3.69e-02 119 4 1 0.250 0.008 TF:M04470_1 tf 1 Factor: NR2E1; motif: AAAAGTCAA; match class: 1 1 Q92556 442 3.84e-02 124 4 1 0.250 0.008 TF:M05358_0 tf 1 Factor: RLF; motif: GCATCRWCATT; match class: 0 1 Q8TD17 442 4.00e-02 4 4 1 0.250 0.250 GO:1904754 BP 1 positive regulation of vascular associated smooth muscle cell migration 1 Q8N1I0 442 4.00e-02 4 4 1 0.250 0.250 GO:0045906 BP 1 negative regulation of vasoconstriction 1 Q8N1I0 442 4.12e-02 133 4 1 0.250 0.008 TF:M06033_0 tf 1 Factor: ZNF878; motif: NGGTTTTANTCM; match class: 0 1 Q13107 442 4.18e-02 135 4 1 0.250 0.007 TF:M06508_0 tf 1 Factor: ZNF114; motif: GGCCGGSTAA; match class: 0 1 Q13107 442 4.35e-02 3009 4 3 0.750 0.001 TF:M04348_0 tf 1 Factor: HOXB3; motif: NNYMATTANN; match class: 0 1 Q13107,Q8N1I0,Q92556 442 4.42e-02 3027 4 3 0.750 0.001 TF:M07428_1 tf 1 Factor: Six-3; motif: NWBTAATNYYWN; match class: 1 1 Q13107,Q8N1I0,Q92556 442 4.42e-02 5838 4 4 1.000 0.001 TF:M00791_1 tf 1 Factor: HNF3; motif: NWRARYAAAYANN; match class: 1 1 Q13107,Q8N1I0,Q92556,Q8TD17 442 4.53e-02 3054 4 3 0.750 0.001 TF:M01073_1 tf 1 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN; match class: 1 1 Q8N1I0,Q92556,Q8TD17 442 4.57e-02 148 4 1 0.250 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 Q92556 442 4.60e-02 23 4 1 0.250 0.043 REAC:5357956 rea 1 TNFR1-induced NFkappaB signaling pathway 1 Q13107 442 4.80e-02 24 4 1 0.250 0.042 REAC:8849471 rea 1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 Q92556 442 4.81e-02 62 4 1 0.250 0.016 KEGG:05131 keg 1 Shigellosis 1 Q92556 442 4.87e-02 1225 4 2 0.500 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 Q8N1I0,Q92556 442 4.87e-02 158 4 1 0.250 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 Q92556 442 5.00e-02 5 4 1 0.250 0.200 GO:0014829 BP 1 vascular smooth muscle contraction 1 Q8N1I0 442 5.00e-02 2 4 1 0.250 0.500 CORUM:5337 cor 1 ELMO1-DOCK1 complex 1 Q92556 442 5.00e-02 5 4 1 0.250 0.200 GO:1904752 BP 1 regulation of vascular associated smooth muscle cell migration 1 Q8N1I0 442 5.00e-02 25 4 1 0.250 0.040 REAC:164952 rea 1 The role of Nef in HIV-1 replication and disease pathogenesis 1 Q92556 442 5.00e-02 5 4 1 0.250 0.200 GO:1904738 BP 1 vascular associated smooth muscle cell migration 1 Q8N1I0 442 5.00e-02 5 4 1 0.250 0.200 GO:0032045 CC 1 guanyl-nucleotide exchange factor complex 1 Q92556 442 5.00e-02 2 4 1 0.250 0.500 CORUM:5341 cor 1 ELMO1-DOCK2 complex 1 Q92556 443 3.74e-03 1118 4 4 1.000 0.004 GO:0044822 MF 1 poly(A) RNA binding 1 Q9NZB2,P14866,Q12905,Q96SI9 443 7.64e-03 1336 4 4 1.000 0.003 GO:0003723 MF 1 RNA binding 1 Q9NZB2,P14866,Q12905,Q96SI9 443 1.40e-02 8 4 1 0.250 0.125 CORUM:5183 cor 1 DNA-PK-Ku-eIF2-NF90-NF45 complex 1 Q12905 443 2.18e-02 114 4 2 0.500 0.018 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 P14866,Q12905 443 2.80e-02 652 4 3 0.750 0.005 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 Q9NZB2,P14866,Q12905 443 2.88e-02 131 4 2 0.500 0.015 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 P14866,Q12905 443 3.47e-02 20 4 1 0.250 0.050 CORUM:1332 cor 1 Large Drosha complex 1 Q12905 443 3.58e-02 249 4 2 0.500 0.008 TF:M04110_0 tf 1 Factor: RUNX3; motif: NRACCGCANWAACCRCAN; match class: 0 1 Q12905,Q96SI9 443 3.62e-02 147 4 2 0.500 0.014 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 P14866,Q12905 443 3.64e-02 362 4 2 0.500 0.006 MI:hsa-miR-20a* mi 1 MI:hsa-miR-20a* 1 Q12905,Q96SI9 443 3.67e-02 148 4 2 0.500 0.014 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 P14866,Q12905 443 3.81e-02 22 4 1 0.250 0.045 CORUM:5615 cor 1 Emerin complex 52 1 P14866 443 4.10e-02 385 4 2 0.500 0.005 MI:mmu-miR-881 mi 1 MI:mmu-miR-881 1 P14866,Q96SI9 443 4.34e-02 161 4 2 0.500 0.012 HPA:021010_13 hpa 1 liver; bile duct cells[Supportive,High] 1 P14866,Q12905 443 4.89e-02 421 4 2 0.500 0.005 MI:hsa-miR-30c-1* mi 1 MI:hsa-miR-30c-1* 1 P14866,Q12905 443 4.91e-02 422 4 2 0.500 0.005 MI:hsa-miR-1 mi 1 MI:hsa-miR-1 1 P14866,Q12905 443 5.00e-02 2136 4 4 1.000 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q9NZB2,P14866,Q12905,Q96SI9 443 5.00e-02 295 4 2 0.500 0.007 TF:M04504_0 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 0 1 Q9NZB2,Q96SI9 443 5.00e-02 295 4 2 0.500 0.007 TF:M04211_0 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 0 1 Q9NZB2,Q96SI9 443 5.00e-02 794 4 3 0.750 0.004 HPA:002020_03 hpa 1 appendix; lymphoid tissue[Uncertain,High] 1 Q9NZB2,P14866,Q12905 443 5.00e-02 426 4 2 0.500 0.005 MI:hsa-miR-381 mi 1 MI:hsa-miR-381 1 P14866,Q12905 443 5.00e-02 295 4 2 0.500 0.007 TF:M04504_1 tf 1 Factor: GMEB2; motif: TTACGTAA; match class: 1 1 Q9NZB2,Q96SI9 443 5.00e-02 295 4 2 0.500 0.007 TF:M04211_1 tf 1 Factor: DBP; motif: NRTTACGTAAYN; match class: 1 1 Q9NZB2,Q96SI9 443 5.00e-02 29 4 1 0.250 0.034 CORUM:1183 cor 1 CDC5L complex 1 Q12905 444 1.93e-03 3 2 1 0.500 0.333 GO:0047023 MF 1 androsterone dehydrogenase activity 1 P17516 444 2.57e-03 4 2 1 0.500 0.250 GO:0071395 BP 1 cellular response to jasmonic acid stimulus 1 P17516 444 2.57e-03 4 2 1 0.500 0.250 GO:0009753 BP 1 response to jasmonic acid 1 P17516 444 3.22e-03 5 2 1 0.500 0.200 GO:0001758 MF 1 retinal dehydrogenase activity 1 P17516 444 3.22e-03 5 2 1 0.500 0.200 GO:0015125 MF 1 bile acid transmembrane transporter activity 1 P17516 444 4.00e-03 10 2 1 0.500 0.100 REAC:193775 rea 1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 1 P17516 444 4.00e-03 10 2 1 0.500 0.100 REAC:193807 rea 1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1 P17516 444 5.14e-03 8 2 1 0.500 0.125 GO:0044597 BP 1 daunorubicin metabolic process 1 P17516 444 5.14e-03 8 2 1 0.500 0.125 GO:0030638 BP 1 polyketide metabolic process 1 P17516 444 5.14e-03 8 2 1 0.500 0.125 GO:0030647 BP 1 aminoglycoside antibiotic metabolic process 1 P17516 444 5.14e-03 8 2 1 0.500 0.125 GO:0044598 BP 1 doxorubicin metabolic process 1 P17516 444 6.80e-03 17 2 1 0.500 0.059 REAC:193368 rea 1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1 P17516 444 7.71e-03 12 2 1 0.500 0.083 GO:0008209 BP 1 androgen metabolic process 1 P17516 444 8.36e-03 13 2 1 0.500 0.077 GO:0016137 BP 1 glycoside metabolic process 1 P17516 444 8.36e-03 13 2 1 0.500 0.077 GO:0015721 BP 1 bile acid and bile salt transport 1 P17516 444 8.80e-03 13 2 1 0.500 0.077 TF:M06281_0 tf 1 Factor: ZNF805; motif: NGKWTCATCAGM; match class: 0 1 Q6UX71 444 9.59e-03 24 2 1 0.500 0.042 REAC:192105 rea 1 Synthesis of bile acids and bile salts 1 P17516 444 1.03e-02 16 2 1 0.500 0.062 GO:0006699 BP 1 bile acid biosynthetic process 1 P17516 444 1.09e-02 17 2 1 0.500 0.059 GO:0008028 MF 1 monocarboxylic acid transmembrane transporter activity 1 P17516 444 1.09e-02 17 2 1 0.500 0.059 GO:0033764 MF 1 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 P17516 444 1.12e-02 28 2 1 0.500 0.036 REAC:194068 rea 1 Bile acid and bile salt metabolism 1 P17516 444 1.16e-02 18 2 1 0.500 0.056 GO:0016229 MF 1 steroid dehydrogenase activity 1 P17516 444 1.29e-02 20 2 1 0.500 0.050 GO:1901661 BP 1 quinone metabolic process 1 P17516 444 1.32e-02 33 2 1 0.500 0.030 REAC:975634 rea 1 Retinoid metabolism and transport 1 P17516 444 1.35e-02 21 2 1 0.500 0.048 GO:0008206 BP 1 bile acid metabolic process 1 P17516 444 1.35e-02 20 2 1 0.500 0.050 TF:M06147_0 tf 1 Factor: ZNF41; motif: NRATAAATGGGA; match class: 0 1 P17516 444 1.41e-02 22 2 1 0.500 0.045 GO:0004033 MF 1 aldo-keto reductase (NADP) activity 1 P17516 444 1.47e-02 10 2 1 0.500 0.100 KEGG:00120 keg 1 Primary bile acid biosynthesis 1 P17516 444 1.48e-02 23 2 1 0.500 0.043 GO:1901618 MF 1 organic hydroxy compound transmembrane transporter activity 1 P17516 444 1.64e-02 41 2 1 0.500 0.024 REAC:6806667 rea 1 Metabolism of fat-soluble vitamins 1 P17516 444 1.79e-02 821 2 2 1.000 0.002 TF:M02013_1 tf 1 Factor: HNF-1alpha; motif: RGTTAATNWTT; match class: 1 1 Q6UX71,P17516 444 1.86e-02 29 2 1 0.500 0.034 GO:0016620 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1 P17516 444 1.93e-02 30 2 1 0.500 0.033 GO:0019748 BP 1 secondary metabolic process 1 P17516 444 2.00e-02 2 2 1 0.500 0.500 OMIM:614279 omi 1 46,XY SEX REVERSAL 8; SRXY8;;MALE PSEUDOHERMAPHRODITISM DUE TO DEFICIENCY OF TESTICULAR 17,20-DESMOLASE;TDD 1 P17516 444 2.18e-02 905 2 2 1.000 0.002 TF:M04087_0 tf 1 Factor: POU4F3; motif: NTGMATWATTAATGNN; match class: 0 1 Q6UX71,P17516 444 2.23e-02 916 2 2 1.000 0.002 TF:M00790_1 tf 1 Factor: HNF1; motif: WRGTTAATNATTAACNNN; match class: 1 1 Q6UX71,P17516 444 2.47e-02 62 2 1 0.500 0.016 REAC:2187338 rea 1 Visual phototransduction 1 P17516 444 2.70e-02 42 2 1 0.500 0.024 GO:0016903 MF 1 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 P17516 444 2.84e-02 42 2 1 0.500 0.024 TF:M04338_0 tf 1 Factor: HNF1B; motif: NRTTAATNATTAACN; match class: 0 1 P17516 444 2.98e-02 44 2 1 0.500 0.023 TF:M03825_1 tf 1 Factor: Gfi1b; motif: YYCAATCWSD; match class: 1 1 Q6UX71 444 3.02e-02 47 2 1 0.500 0.021 GO:0001523 BP 1 retinoid metabolic process 1 P17516 444 3.02e-02 47 2 1 0.500 0.021 GO:0034754 BP 1 cellular hormone metabolic process 1 P17516 444 3.14e-02 49 2 1 0.500 0.020 GO:0016101 BP 1 diterpenoid metabolic process 1 P17516 444 3.27e-02 51 2 1 0.500 0.020 GO:0016655 MF 1 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1 P17516 444 3.47e-02 54 2 1 0.500 0.019 GO:0006721 BP 1 terpenoid metabolic process 1 P17516 444 4.04e-02 63 2 1 0.500 0.016 GO:0015718 BP 1 monocarboxylic acid transport 1 P17516 444 4.33e-02 64 2 1 0.500 0.016 TF:M05591_0 tf 1 Factor: ZNF215; motif: GAGWATGCGGM; match class: 0 1 Q6UX71 444 4.36e-02 68 2 1 0.500 0.015 GO:0006720 BP 1 isoprenoid metabolic process 1 P17516 444 4.62e-02 72 2 1 0.500 0.014 GO:0005319 MF 1 lipid transporter activity 1 P17516 444 4.62e-02 72 2 1 0.500 0.014 GO:0009055 MF 1 electron carrier activity 1 P17516 444 4.66e-02 69 2 1 0.500 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 P17516 444 4.69e-02 1328 2 2 1.000 0.002 TF:M04085_0 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 0 1 Q6UX71,P17516 444 4.74e-02 74 2 1 0.500 0.014 GO:0046943 MF 1 carboxylic acid transmembrane transporter activity 1 P17516 444 4.74e-02 74 2 1 0.500 0.014 GO:0071229 BP 1 cellular response to acid chemical 1 P17516 444 4.80e-02 71 2 1 0.500 0.014 TF:M04337_0 tf 1 Factor: HNF1B; motif: GTTAATNATTAAY; match class: 0 1 P17516 444 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-149* mi 1 MI:hsa-miR-149* 1 P17516 444 4.81e-02 75 2 1 0.500 0.013 GO:0005342 MF 1 organic acid transmembrane transporter activity 1 P17516 444 4.81e-02 75 2 1 0.500 0.013 GO:0006694 BP 1 steroid biosynthetic process 1 P17516 444 4.93e-02 73 2 1 0.500 0.014 TF:M03996_1 tf 1 Factor: SPIC; motif: NAAAAGMGGAAGTA; match class: 1 1 Q6UX71 444 5.00e-02 10 2 1 0.500 0.100 HP:0012245 hp 1 Sex reversal 1 P17516 444 5.00e-02 34 2 1 0.500 0.029 KEGG:00140 keg 1 Steroid hormone biosynthesis 1 P17516 444 5.00e-02 74 2 1 0.500 0.014 TF:M03979_1 tf 1 Factor: ETV1; motif: ACCGGAAGTN; match class: 1 1 P17516 444 5.00e-02 126 2 1 0.500 0.008 REAC:196854 rea 1 Metabolism of vitamins and cofactors 1 P17516 444 5.00e-02 78 2 1 0.500 0.013 GO:0016651 MF 1 oxidoreductase activity, acting on NAD(P)H 1 P17516 444 5.00e-02 10 2 1 0.500 0.100 HP:0012244 hp 1 Abnormal sex determination 1 P17516 444 5.00e-02 5 2 1 0.500 0.200 OMIM:400044 omi 1 46,XY Sex Reversal 1 P17516 445 7.00e-08 3 2 2 1.000 0.667 GO:0019814 CC 1 immunoglobulin complex 1 P15814,B9A064 445 7.00e-08 3 2 2 1.000 0.667 GO:0042571 CC 1 immunoglobulin complex, circulating 1 P15814,B9A064 445 3.50e-07 6 2 2 1.000 0.333 GO:0034987 MF 1 immunoglobulin receptor binding 1 P15814,B9A064 445 3.50e-07 6 2 2 1.000 0.333 GO:0006958 BP 1 complement activation, classical pathway 1 P15814,B9A064 445 4.90e-07 7 2 2 1.000 0.286 GO:0006910 BP 1 phagocytosis, recognition 1 P15814,B9A064 445 4.90e-07 7 2 2 1.000 0.286 GO:0002455 BP 1 humoral immune response mediated by circulating immunoglobulin 1 P15814,B9A064 445 3.17e-06 17 2 2 1.000 0.118 GO:0006911 BP 1 phagocytosis, engulfment 1 P15814,B9A064 445 5.90e-06 23 2 2 1.000 0.087 GO:0016064 BP 1 immunoglobulin mediated immune response 1 P15814,B9A064 445 6.44e-06 24 2 2 1.000 0.083 GO:0050871 BP 1 positive regulation of B cell activation 1 P15814,B9A064 445 6.44e-06 24 2 2 1.000 0.083 GO:0050853 BP 1 B cell receptor signaling pathway 1 P15814,B9A064 445 6.44e-06 24 2 2 1.000 0.083 GO:0019724 BP 1 B cell mediated immunity 1 P15814,B9A064 445 7.00e-06 25 2 2 1.000 0.080 GO:0099024 BP 1 plasma membrane invagination 1 P15814,B9A064 445 1.16e-05 32 2 2 1.000 0.062 GO:0006956 BP 1 complement activation 1 P15814,B9A064 445 1.16e-05 32 2 2 1.000 0.062 GO:0010324 BP 1 membrane invagination 1 P15814,B9A064 445 1.64e-05 38 2 2 1.000 0.053 GO:0050864 BP 1 regulation of B cell activation 1 P15814,B9A064 445 2.01e-05 42 2 2 1.000 0.048 GO:0003823 MF 1 antigen binding 1 P15814,B9A064 445 2.63e-05 48 2 2 1.000 0.042 GO:0072376 BP 1 protein activation cascade 1 P15814,B9A064 445 3.99e-05 59 2 2 1.000 0.034 GO:0008037 BP 1 cell recognition 1 P15814,B9A064 445 5.00e-05 66 2 2 1.000 0.030 GO:0009897 CC 1 external side of plasma membrane 1 P15814,B9A064 445 5.96e-05 72 2 2 1.000 0.028 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 P15814,B9A064 445 6.47e-05 75 2 2 1.000 0.027 GO:0042742 BP 1 defense response to bacterium 1 P15814,B9A064 445 6.65e-05 76 2 2 1.000 0.026 GO:0006959 BP 1 humoral immune response 1 P15814,B9A064 445 6.83e-05 77 2 2 1.000 0.026 GO:0002449 BP 1 lymphocyte mediated immunity 1 P15814,B9A064 445 7.94e-05 83 2 2 1.000 0.024 GO:0072562 CC 1 blood microparticle 1 P15814,B9A064 445 8.53e-05 86 2 2 1.000 0.023 GO:0042113 BP 1 B cell activation 1 P15814,B9A064 445 1.04e-04 95 2 2 1.000 0.021 GO:0002250 BP 1 adaptive immune response 1 P15814,B9A064 445 1.32e-04 107 2 2 1.000 0.019 GO:0002443 BP 1 leukocyte mediated immunity 1 P15814,B9A064 445 1.53e-04 115 2 2 1.000 0.017 GO:0051251 BP 1 positive regulation of lymphocyte activation 1 P15814,B9A064 445 1.87e-04 127 2 2 1.000 0.016 GO:0002696 BP 1 positive regulation of leukocyte activation 1 P15814,B9A064 445 2.02e-04 132 2 2 1.000 0.015 GO:0050867 BP 1 positive regulation of cell activation 1 P15814,B9A064 445 2.34e-04 142 2 2 1.000 0.014 GO:0006909 BP 1 phagocytosis 1 P15814,B9A064 445 2.37e-04 143 2 2 1.000 0.014 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 P15814,B9A064 445 2.71e-04 153 2 2 1.000 0.013 GO:0051249 BP 1 regulation of lymphocyte activation 1 P15814,B9A064 445 3.12e-04 164 2 2 1.000 0.012 GO:0009617 BP 1 response to bacterium 1 P15814,B9A064 445 3.27e-04 168 2 2 1.000 0.012 GO:0098542 BP 1 defense response to other organism 1 P15814,B9A064 445 3.72e-04 179 2 2 1.000 0.011 GO:0002694 BP 1 regulation of leukocyte activation 1 P15814,B9A064 445 4.55e-04 198 2 2 1.000 0.010 GO:0050865 BP 1 regulation of cell activation 1 P15814,B9A064 445 5.37e-04 215 2 2 1.000 0.009 GO:0098552 CC 1 side of membrane 1 P15814,B9A064 445 5.42e-04 216 2 2 1.000 0.009 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 P15814,B9A064 445 6.41e-04 235 2 2 1.000 0.009 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 P15814,B9A064 445 6.58e-04 238 2 2 1.000 0.008 GO:0046649 BP 1 lymphocyte activation 1 P15814,B9A064 445 9.44e-04 285 2 2 1.000 0.007 GO:0045321 BP 1 leukocyte activation 1 P15814,B9A064 445 1.07e-03 303 2 2 1.000 0.007 GO:0002757 BP 1 immune response-activating signal transduction 1 P15814,B9A064 445 1.08e-03 305 2 2 1.000 0.007 GO:0043207 BP 1 response to external biotic stimulus 1 P15814,B9A064 445 1.08e-03 305 2 2 1.000 0.007 GO:0051707 BP 1 response to other organism 1 P15814,B9A064 445 1.12e-03 311 2 2 1.000 0.006 GO:0009986 CC 1 cell surface 1 P15814,B9A064 445 1.17e-03 317 2 2 1.000 0.006 GO:0002252 BP 1 immune effector process 1 P15814,B9A064 445 1.21e-03 322 2 2 1.000 0.006 GO:0002764 BP 1 immune response-regulating signaling pathway 1 P15814,B9A064 445 1.22e-03 324 2 2 1.000 0.006 GO:0009607 BP 1 response to biotic stimulus 1 P15814,B9A064 445 1.32e-03 337 2 2 1.000 0.006 GO:0002253 BP 1 activation of immune response 1 P15814,B9A064 445 1.46e-03 354 2 2 1.000 0.006 GO:0006897 BP 1 endocytosis 1 P15814,B9A064 445 1.72e-03 385 2 2 1.000 0.005 GO:0001775 BP 1 cell activation 1 P15814,B9A064 445 1.74e-03 387 2 2 1.000 0.005 GO:0050778 BP 1 positive regulation of immune response 1 P15814,B9A064 445 1.99e-03 414 2 2 1.000 0.005 GO:0045087 BP 1 innate immune response 1 P15814,B9A064 445 2.90e-03 499 2 2 1.000 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 P15814,B9A064 445 2.92e-03 501 2 2 1.000 0.004 GO:0050776 BP 1 regulation of immune response 1 P15814,B9A064 445 2.98e-03 4 2 1 0.500 0.250 HP:0100280 hp 1 Crohn's disease 1 P15814 445 3.72e-03 5 2 1 0.500 0.200 HP:0002743 hp 1 Recurrent enteroviral infections 1 P15814 445 5.17e-03 666 2 2 1.000 0.003 GO:0006952 BP 1 defense response 1 P15814,B9A064 445 5.20e-03 668 2 2 1.000 0.003 GO:0005615 CC 1 extracellular space 1 P15814,B9A064 445 5.54e-03 690 2 2 1.000 0.003 GO:0002682 BP 1 regulation of immune system process 1 P15814,B9A064 445 6.22e-03 731 2 2 1.000 0.003 GO:0005102 MF 1 receptor binding 1 P15814,B9A064 445 6.36e-03 739 2 2 1.000 0.003 GO:0006955 BP 1 immune response 1 P15814,B9A064 445 6.53e-03 749 2 2 1.000 0.003 GO:0061024 BP 1 membrane organization 1 P15814,B9A064 445 6.69e-03 9 2 1 0.500 0.111 HP:0004432 hp 1 Agammaglobulinemia 1 P15814 445 8.12e-03 835 2 2 1.000 0.002 GO:0009605 BP 1 response to external stimulus 1 P15814,B9A064 445 8.62e-03 55 2 1 0.500 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 P15814 445 1.07e-02 958 2 2 1.000 0.002 GO:0016192 BP 1 vesicle-mediated transport 1 P15814,B9A064 445 1.19e-02 16 2 1 0.500 0.062 HP:0100658 hp 1 Cellulitis 1 P15814 445 1.37e-02 1086 2 2 1.000 0.002 GO:0048584 BP 1 positive regulation of response to stimulus 1 P15814,B9A064 445 1.41e-02 19 2 1 0.500 0.053 HP:0200043 hp 1 Verrucae 1 P15814 445 1.41e-02 19 2 1 0.500 0.053 HP:0010976 hp 1 B lymphocytopenia 1 P15814 445 1.56e-02 21 2 1 0.500 0.048 HP:0012740 hp 1 Papilloma 1 P15814 445 1.58e-02 1165 2 2 1.000 0.002 GO:0002376 BP 1 immune system process 1 P15814,B9A064 445 1.63e-02 22 2 1 0.500 0.045 HP:0010975 hp 1 Abnormality of B cell number 1 P15814 445 1.67e-02 1 2 1 0.500 1.000 OMIM:613500 omi 1 AGAMMAGLOBULINEMIA 2, AUTOSOMAL RECESSIVE; AGM2;;AGAMMAGLOBULINEMIA, AUTOSOMAL RECESSIVE, DUE TO IGLL1 DEFECT 1 P15814 445 1.89e-02 1272 2 2 1.000 0.002 GO:0044459 CC 1 plasma membrane part 1 P15814,B9A064 445 2.34e-02 1416 2 2 1.000 0.001 GO:0007166 BP 1 cell surface receptor signaling pathway 1 P15814,B9A064 445 2.37e-02 32 2 1 0.500 0.031 HP:0004429 hp 1 Recurrent viral infections 1 P15814 445 2.37e-02 32 2 1 0.500 0.031 HP:0002754 hp 1 Osteomyelitis 1 P15814 445 2.52e-02 34 2 1 0.500 0.029 HP:0040088 hp 1 Abnormal lymphocyte count 1 P15814 445 2.59e-02 35 2 1 0.500 0.029 HP:0011109 hp 1 Chronic sinusitis 1 P15814 445 2.62e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 P15814,B9A064 445 2.81e-02 38 2 1 0.500 0.026 HP:0100806 hp 1 Sepsis 1 P15814 445 2.85e-02 183 2 1 0.500 0.005 TF:M06623_0 tf 1 Factor: ZNF778; motif: NTMAGWTTGCGC; match class: 0 1 P15814 445 3.18e-02 43 2 1 0.500 0.023 HP:0011108 hp 1 Recurrent sinusitis 1 P15814 445 3.18e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 P15814,B9A064 445 3.29e-02 211 2 1 0.500 0.005 TF:M03938_0 tf 1 Factor: ZNF524; motif: CTCGAACCCKTGNN; match class: 0 1 P15814 445 3.32e-02 45 2 1 0.500 0.022 HP:0000988 hp 1 Skin rash 1 P15814 445 3.40e-02 46 2 1 0.500 0.022 HP:0004386 hp 1 Gastrointestinal inflammation 1 P15814 445 3.47e-02 47 2 1 0.500 0.021 HP:0001287 hp 1 Meningitis 1 P15814 445 3.76e-02 51 2 1 0.500 0.020 HP:0001944 hp 1 Dehydration 1 P15814 445 3.83e-02 52 2 1 0.500 0.019 HP:0002837 hp 1 Recurrent bronchitis 1 P15814 445 3.94e-02 253 2 1 0.500 0.004 TF:M01044_0 tf 1 Factor: Tbx5; motif: CTCACACCTT; match class: 0 1 P15814 445 4.17e-02 268 2 1 0.500 0.004 TF:M01288_1 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 1 1 P15814 445 4.27e-02 58 2 1 0.500 0.017 HP:0008572 hp 1 External ear malformation 1 P15814 445 4.27e-02 58 2 1 0.500 0.017 HP:0000509 hp 1 Conjunctivitis 1 P15814 445 4.34e-02 59 2 1 0.500 0.017 HP:0002110 hp 1 Bronchiectasis 1 P15814 445 4.35e-02 280 2 1 0.500 0.004 TF:M06160_0 tf 1 Factor: ZNF92; motif: NGWTGMGGWWGM; match class: 0 1 P15814 445 4.42e-02 60 2 1 0.500 0.017 HP:0012387 hp 1 Bronchitis 1 P15814 445 4.49e-02 61 2 1 0.500 0.016 HP:0011450 hp 1 CNS infection 1 P15814 445 4.64e-02 63 2 1 0.500 0.016 HP:0002718 hp 1 Recurrent bacterial infections 1 P15814 445 4.71e-02 64 2 1 0.500 0.016 HP:0006532 hp 1 Recurrent pneumonia 1 P15814 445 4.77e-02 307 2 1 0.500 0.003 TF:M04622_0 tf 1 Factor: Nur77; motif: RAAGGTCANN; match class: 0 1 P15814 445 4.81e-02 310 2 1 0.500 0.003 TF:M04148_1 tf 1 Factor: TFAP2A; motif: NGCCCYNNGGGCN; match class: 1 1 P15814 445 5.00e-02 19 2 1 0.500 0.053 KEGG:05340 keg 1 Primary immunodeficiency 1 P15814 445 5.00e-02 2071 2 2 1.000 0.001 GO:0006950 BP 1 response to stress 1 P15814,B9A064 445 5.00e-02 3 2 1 0.500 0.333 OMIM:601495 omi 1 Autosomal Agammaglobulinemia 1 P15814 445 5.00e-02 1 2 1 0.500 1.000 CORUM:1703 cor 1 IGHM-VPREB1-IGLL1 complex 1 P15814 446 5.50e-07 6 2 2 1.000 0.333 GO:0048500 CC 1 signal recognition particle 1 P37108,P49458 446 5.50e-07 6 2 2 1.000 0.333 GO:0005786 CC 1 signal recognition particle, endoplasmic reticulum targeting 1 P37108,P49458 446 1.50e-04 91 2 2 1.000 0.022 GO:0006614 BP 1 SRP-dependent cotranslational protein targeting to membrane 1 P37108,P49458 446 1.74e-04 98 2 2 1.000 0.020 GO:0006613 BP 1 cotranslational protein targeting to membrane 1 P37108,P49458 446 1.78e-04 99 2 2 1.000 0.020 GO:0045047 BP 1 protein targeting to ER 1 P37108,P49458 446 1.93e-04 103 2 2 1.000 0.019 GO:0072599 BP 1 establishment of protein localization to endoplasmic reticulum 1 P37108,P49458 446 2.53e-04 118 2 2 1.000 0.017 GO:0070972 BP 1 protein localization to endoplasmic reticulum 1 P37108,P49458 446 4.38e-04 155 2 2 1.000 0.013 GO:0006612 BP 1 protein targeting to membrane 1 P37108,P49458 446 4.47e-04 111 2 2 1.000 0.018 REAC:1799339 rea 1 SRP-dependent cotranslational protein targeting to membrane 1 P37108,P49458 446 8.74e-04 155 2 2 1.000 0.013 REAC:72766 rea 1 Translation 1 P37108,P49458 446 1.27e-03 3 2 1 0.500 0.333 GO:0006616 BP 1 SRP-dependent cotranslational protein targeting to membrane, translocation 1 P49458 446 1.27e-03 3 2 1 0.500 0.333 GO:0005785 CC 1 signal recognition particle receptor complex 1 P49458 446 1.54e-03 290 2 2 1.000 0.007 GO:0090150 BP 1 establishment of protein localization to membrane 1 P37108,P49458 446 1.69e-03 4 2 1 0.500 0.250 GO:0008312 MF 1 7S RNA binding 1 P37108 446 2.11e-03 5 2 1 0.500 0.200 GO:0005047 MF 1 signal recognition particle binding 1 P49458 446 2.49e-03 369 2 2 1.000 0.005 GO:0072657 BP 1 protein localization to membrane 1 P37108,P49458 446 3.80e-03 9 2 1 0.500 0.111 GO:0030867 CC 1 rough endoplasmic reticulum membrane 1 P49458 446 4.30e-03 485 2 2 1.000 0.004 GO:0072594 BP 1 establishment of protein localization to organelle 1 P37108,P49458 446 4.34e-03 487 2 2 1.000 0.004 GO:0006605 BP 1 protein targeting 1 P37108,P49458 446 6.03e-03 574 2 2 1.000 0.003 GO:1902582 BP 1 single-organism intracellular transport 1 P37108,P49458 446 6.57e-03 599 2 2 1.000 0.003 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P37108,P49458 446 6.59e-03 600 2 2 1.000 0.003 GO:1990904 CC 1 ribonucleoprotein complex 1 P37108,P49458 446 7.26e-03 630 2 2 1.000 0.003 GO:0044802 BP 1 single-organism membrane organization 1 P37108,P49458 446 7.90e-03 657 2 2 1.000 0.003 GO:0033365 BP 1 protein localization to organelle 1 P37108,P49458 446 9.20e-03 709 2 2 1.000 0.003 GO:0006886 BP 1 intracellular protein transport 1 P37108,P49458 446 1.03e-02 749 2 2 1.000 0.003 GO:0061024 BP 1 membrane organization 1 P37108,P49458 446 1.09e-02 771 2 2 1.000 0.003 GO:1902580 BP 1 single-organism cellular localization 1 P37108,P49458 446 1.18e-02 28 2 1 0.500 0.036 GO:0005791 CC 1 rough endoplasmic reticulum 1 P49458 446 1.70e-02 964 2 2 1.000 0.002 GO:0015031 BP 1 protein transport 1 P37108,P49458 446 1.73e-02 41 2 1 0.500 0.024 GO:0065002 BP 1 intracellular protein transmembrane transport 1 P49458 446 1.77e-02 42 2 1 0.500 0.024 GO:0071806 BP 1 protein transmembrane transport 1 P49458 446 1.93e-02 314 2 2 1.000 0.006 MI:hsa-miR-24-1* mi 1 MI:hsa-miR-24-1* 1 P37108,P49458 446 2.03e-02 322 2 2 1.000 0.006 MI:hsa-miR-24-2* mi 1 MI:hsa-miR-24-2* 1 P37108,P49458 446 2.22e-02 1100 2 2 1.000 0.002 GO:0045184 BP 1 establishment of protein localization 1 P37108,P49458 446 2.26e-02 1111 2 2 1.000 0.002 GO:0034613 BP 1 cellular protein localization 1 P37108,P49458 446 2.30e-02 1121 2 2 1.000 0.002 GO:0070727 BP 1 cellular macromolecule localization 1 P37108,P49458 446 2.74e-02 65 2 1 0.500 0.015 GO:0043021 MF 1 ribonucleoprotein complex binding 1 P49458 446 2.80e-02 1237 2 2 1.000 0.002 GO:0046907 BP 1 intracellular transport 1 P37108,P49458 446 2.95e-02 388 2 2 1.000 0.005 MI:mmu-miR-679 mi 1 MI:mmu-miR-679 1 P37108,P49458 446 3.21e-02 405 2 2 1.000 0.005 MI:hsa-miR-943 mi 1 MI:hsa-miR-943 1 P37108,P49458 446 3.27e-02 1336 2 2 1.000 0.001 GO:0003723 MF 1 RNA binding 1 P37108,P49458 446 3.42e-02 418 2 2 1.000 0.005 MI:hsa-miR-801 mi 1 MI:hsa-miR-801 1 P37108,P49458 446 3.47e-02 1377 2 2 1.000 0.001 GO:0071702 BP 1 organic substance transport 1 P37108,P49458 446 3.47e-02 421 2 2 1.000 0.005 MI:hsa-miR-603 mi 1 MI:hsa-miR-603 1 P37108,P49458 446 3.55e-02 1393 2 2 1.000 0.001 GO:0008104 BP 1 protein localization 1 P37108,P49458 446 3.61e-02 429 2 2 1.000 0.005 MI:rno-miR-664 mi 1 MI:rno-miR-664 1 P37108,P49458 446 3.79e-02 90 2 1 0.500 0.011 GO:0042493 BP 1 response to drug 1 P37108 446 3.85e-02 10 2 1 0.500 0.100 TF:M06009_0 tf 1 Factor: ZNF175; motif: NGDTCAAGAATG; match class: 0 1 P49458 446 4.08e-02 1493 2 2 1.000 0.001 GO:0051649 BP 1 establishment of localization in cell 1 P37108,P49458 446 4.11e-02 1498 2 2 1.000 0.001 GO:0044765 BP 1 single-organism transport 1 P37108,P49458 446 4.80e-02 1618 2 2 1.000 0.001 GO:0033036 BP 1 macromolecule localization 1 P37108,P49458 446 5.00e-02 1652 2 2 1.000 0.001 GO:1902578 BP 1 single-organism localization 1 P37108,P49458 446 5.00e-02 13 2 1 0.500 0.077 TF:M04389_0 tf 1 Factor: LHX6; motif: TGATTGCAATYA; match class: 0 1 P37108 446 5.00e-02 505 2 2 1.000 0.004 MI:hsa-miR-548a-5p mi 1 MI:hsa-miR-548a-5p 1 P37108,P49458 446 5.00e-02 13 2 1 0.500 0.077 TF:M04389_1 tf 1 Factor: LHX6; motif: TGATTGCAATYA; match class: 1 1 P37108 446 5.00e-02 22 2 2 1.000 0.091 KEGG:03060 keg 1 Protein export 1 P37108,P49458 446 5.00e-02 1169 2 2 1.000 0.002 REAC:392499 rea 1 Metabolism of proteins 1 P37108,P49458 447 3.88e-23 38 9 9 1.000 0.237 GO:0003954 MF 1 NADH dehydrogenase activity 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.88e-23 38 9 9 1.000 0.237 GO:0008137 MF 1 NADH dehydrogenase (ubiquinone) activity 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.88e-23 38 9 9 1.000 0.237 GO:0050136 MF 1 NADH dehydrogenase (quinone) activity 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.34e-22 43 9 9 1.000 0.209 GO:0006120 BP 1 mitochondrial electron transport, NADH to ubiquinone 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.69e-22 44 9 9 1.000 0.205 GO:0005747 CC 1 mitochondrial respiratory chain complex I 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.69e-22 44 9 9 1.000 0.205 GO:0045271 CC 1 respiratory chain complex I 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.69e-22 44 9 9 1.000 0.205 GO:0030964 CC 1 NADH dehydrogenase complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.24e-22 51 9 9 1.000 0.176 GO:0016655 MF 1 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.14e-21 57 9 9 1.000 0.158 GO:0097031 BP 1 mitochondrial respiratory chain complex I biogenesis 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.14e-21 57 9 9 1.000 0.158 GO:0010257 BP 1 NADH dehydrogenase complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.14e-21 57 9 9 1.000 0.158 GO:0032981 BP 1 mitochondrial respiratory chain complex I assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.83e-21 62 9 9 1.000 0.145 GO:0098803 CC 1 respiratory chain complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 6.55e-21 64 9 9 1.000 0.141 GO:0005746 CC 1 mitochondrial respiratory chain 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.02e-20 67 9 9 1.000 0.134 GO:0070469 CC 1 respiratory chain 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.77e-20 71 9 9 1.000 0.127 GO:0042775 BP 1 mitochondrial ATP synthesis coupled electron transport 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.02e-20 72 9 9 1.000 0.125 GO:0042773 BP 1 ATP synthesis coupled electron transport 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.63e-20 74 9 9 1.000 0.122 GO:0033108 BP 1 mitochondrial respiratory chain complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.34e-20 78 9 9 1.000 0.115 GO:0016651 MF 1 oxidoreductase activity, acting on NAD(P)H 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.34e-20 78 9 9 1.000 0.115 GO:1990204 CC 1 oxidoreductase complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.52e-20 80 9 9 1.000 0.113 GO:0022900 BP 1 electron transport chain 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.52e-20 80 9 9 1.000 0.113 GO:0022904 BP 1 respiratory electron transport chain 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 9.80e-20 85 9 9 1.000 0.106 GO:0006119 BP 1 oxidative phosphorylation 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.53e-19 94 9 9 1.000 0.096 GO:0098800 CC 1 inner mitochondrial membrane protein complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.20e-18 111 9 9 1.000 0.081 GO:0098798 CC 1 mitochondrial protein complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.24e-18 130 9 9 1.000 0.069 GO:0045333 BP 1 cellular respiration 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.27e-17 143 9 9 1.000 0.063 GO:0044455 CC 1 mitochondrial membrane part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 6.24e-17 39 9 9 1.000 0.231 CORUM:178 cor 1 Respiratory chain complex I (holoenzyme), mitochondrial 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 9.58e-17 178 9 9 1.000 0.051 GO:0046034 BP 1 ATP metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.12e-16 181 9 9 1.000 0.050 GO:0015980 BP 1 energy derivation by oxidation of organic compounds 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.66e-16 189 9 9 1.000 0.048 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.75e-16 190 9 9 1.000 0.047 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.02e-16 193 9 9 1.000 0.047 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.93e-16 201 9 9 1.000 0.045 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.93e-16 201 9 9 1.000 0.045 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.21e-16 203 9 9 1.000 0.044 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.67e-16 206 9 9 1.000 0.044 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.32e-16 51 9 9 1.000 0.176 REAC:6799198 rea 1 Complex I biogenesis 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.38e-16 210 9 9 1.000 0.043 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.49e-15 240 9 9 1.000 0.037 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.67e-15 243 9 9 1.000 0.037 GO:0042278 BP 1 purine nucleoside metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.24e-15 251 9 9 1.000 0.036 GO:0009119 BP 1 ribonucleoside metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.78e-15 257 9 9 1.000 0.035 GO:0006091 BP 1 generation of precursor metabolites and energy 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 6.29e-15 281 9 9 1.000 0.032 GO:0009116 BP 1 nucleoside metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.80e-15 16 9 7 0.778 0.438 CORUM:2920 cor 1 Respiratory chain complex I (lambda subunit) mitochondrial 1 Q16718,O75306,O43181,P49821,Q9UI09,O75489,O95182 447 1.11e-14 299 9 9 1.000 0.030 GO:1901657 BP 1 glycosyl compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.21e-14 302 9 9 1.000 0.030 GO:0005743 CC 1 mitochondrial inner membrane 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.25e-14 303 9 9 1.000 0.030 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.41e-14 307 9 9 1.000 0.029 GO:0009259 BP 1 ribonucleotide metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.00e-14 319 9 9 1.000 0.028 GO:0019693 BP 1 ribose phosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.31e-14 324 9 9 1.000 0.028 GO:0006163 BP 1 purine nucleotide metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.37e-14 325 9 9 1.000 0.028 GO:0019866 CC 1 organelle inner membrane 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.66e-14 350 9 9 1.000 0.026 GO:0072521 BP 1 purine-containing compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.73e-14 375 9 9 1.000 0.024 GO:0055114 BP 1 oxidation-reduction process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.00e-13 90 9 9 1.000 0.100 REAC:611105 rea 1 Respiratory electron transport 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.19e-13 388 9 9 1.000 0.023 GO:0009117 BP 1 nucleotide metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.28e-13 391 9 9 1.000 0.023 GO:0043623 BP 1 cellular protein complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.50e-13 398 9 9 1.000 0.023 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.53e-13 399 9 9 1.000 0.023 GO:0031966 CC 1 mitochondrial membrane 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.29e-13 434 9 9 1.000 0.021 GO:0005740 CC 1 mitochondrial envelope 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.05e-13 444 9 9 1.000 0.020 GO:0098796 CC 1 membrane protein complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.58e-13 450 9 9 1.000 0.020 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 6.60e-13 110 9 9 1.000 0.082 REAC:163200 rea 1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.22e-13 480 9 9 1.000 0.019 GO:0016491 MF 1 oxidoreductase activity 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.43e-12 510 9 9 1.000 0.018 GO:0007005 BP 1 mitochondrion organization 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.42e-11 153 9 9 1.000 0.059 REAC:1428517 rea 1 The citric acid (TCA) cycle and respiratory electron transport 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.58e-11 665 9 9 1.000 0.014 GO:0031967 CC 1 organelle envelope 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.64e-11 668 9 9 1.000 0.013 GO:0031975 CC 1 envelope 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.78e-11 674 9 9 1.000 0.013 GO:0019637 BP 1 organophosphate metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.78e-11 674 9 9 1.000 0.013 GO:0044429 CC 1 mitochondrial part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.18e-11 689 9 9 1.000 0.013 GO:0034622 BP 1 cellular macromolecular complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.25e-11 109 9 9 1.000 0.083 KEGG:00190 keg 1 Oxidative phosphorylation 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.22e-11 798 9 9 1.000 0.011 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.10e-10 118 9 9 1.000 0.076 KEGG:05012 keg 1 Parkinson's disease 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.34e-10 842 9 9 1.000 0.011 GO:0070271 BP 1 protein complex biogenesis 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.34e-10 842 9 9 1.000 0.011 GO:0006461 BP 1 protein complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.88e-10 125 9 9 1.000 0.072 KEGG:04932 keg 1 Non-alcoholic fatty liver disease (NAFLD) 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.00e-10 144 9 9 1.000 0.062 KEGG:05010 keg 1 Alzheimer's disease 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.23e-10 1015 9 9 1.000 0.009 GO:0071822 BP 1 protein complex subunit organization 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.19e-10 1029 9 9 1.000 0.009 GO:0005739 CC 1 mitochondrion 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.48e-10 1033 9 9 1.000 0.009 GO:1902494 CC 1 catalytic complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.66e-09 1113 9 9 1.000 0.008 GO:0065003 BP 1 macromolecular complex assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.61e-09 166 9 9 1.000 0.054 KEGG:05016 keg 1 Huntington's disease 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.32e-09 1266 9 9 1.000 0.007 GO:0016310 BP 1 phosphorylation 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.48e-09 1333 9 9 1.000 0.007 GO:0044281 BP 1 small molecule metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.44e-08 1414 9 9 1.000 0.006 GO:0031090 CC 1 organelle membrane 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.61e-08 1565 9 9 1.000 0.006 GO:1901564 BP 1 organonitrogen compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.77e-08 1614 9 9 1.000 0.006 GO:0043933 BP 1 macromolecular complex subunit organization 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.02e-08 1369 9 9 1.000 0.007 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.08e-08 11 9 4 0.444 0.364 CORUM:2948 cor 1 Respiratory chain complex I (incomplete intermediate), mitochondrial 1 O75306,O43181,O95169,P49821 447 6.25e-08 35 9 5 0.556 0.143 HP:0001404 hp 1 Hepatocellular necrosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 7.86e-08 1706 9 9 1.000 0.005 GO:0022607 BP 1 cellular component assembly 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.10e-07 39 9 5 0.556 0.128 HP:0002605 hp 1 Hepatic necrosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.64e-07 1851 9 9 1.000 0.005 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.31e-07 1923 9 9 1.000 0.005 GO:0006793 BP 1 phosphorus metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.41e-07 1932 9 9 1.000 0.005 GO:0044085 BP 1 cellular component biogenesis 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.03e-07 2096 9 9 1.000 0.004 GO:0043234 CC 1 protein complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.64e-07 22 9 4 0.444 0.182 HP:0006965 hp 1 Acute necrotizing encephalopathy 1 O75306,O43181,P49821,O75489 447 1.00e-06 2262 9 9 1.000 0.004 GO:0006996 BP 1 organelle organization 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.02e-06 60 9 5 0.556 0.083 HP:0030085 hp 1 Abnormal CSF lactate level 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.02e-06 60 9 5 0.556 0.083 HP:0002490 hp 1 Increased CSF lactate 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.11e-06 24 9 4 0.444 0.167 HP:0008316 hp 1 Abnormal mitochondria in muscle tissue 1 O75306,O43181,P49821,O75489 447 1.53e-06 65 9 5 0.556 0.077 HP:0007305 hp 1 CNS demyelination 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.55e-06 26 9 4 0.444 0.154 HP:0006846 hp 1 Acute encephalopathy 1 O75306,O43181,P49821,O75489 447 1.78e-06 2412 9 9 1.000 0.004 GO:0044425 CC 1 membrane part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.93e-06 68 9 5 0.556 0.074 HP:0001427 hp 1 Mitochondrial inheritance 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.12e-06 28 9 4 0.444 0.143 HP:0004481 hp 1 Progressive macrocephaly 1 O75306,O43181,P49821,O75489 447 3.05e-06 2560 9 9 1.000 0.004 GO:0044710 BP 1 single-organism metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.24e-06 476 9 6 0.667 0.013 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 4.76e-06 34 9 4 0.444 0.118 HP:0002181 hp 1 Cerebral edema 1 O75306,O43181,P49821,O75489 447 7.07e-06 10 9 3 0.333 0.300 CORUM:2904 cor 1 Respiratory chain complex I (intermediate VII/650kD), mitochondrial 1 O75306,O43181,O75489 447 9.70e-06 11 9 3 0.333 0.273 CORUM:2905 cor 1 Respiratory chain complex I (holoenzyme), mitochondrial 1 O75306,O43181,O75489 447 1.03e-05 95 9 5 0.556 0.053 HP:0000712 hp 1 Emotional lability 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.09e-05 96 9 5 0.556 0.052 HP:0002878 hp 1 Respiratory failure 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.55e-05 103 9 5 0.556 0.049 HP:0000602 hp 1 Ophthalmoplegia 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.55e-05 103 9 5 0.556 0.049 HP:0002171 hp 1 Gliosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.96e-05 108 9 5 0.556 0.046 HP:0002151 hp 1 Increased serum lactate 1 O75306,O43181,P49821,Q9UI09,O75489 447 3.64e-05 56 9 4 0.444 0.071 HP:0002415 hp 1 Leukodystrophy 1 O75306,O43181,P49821,O75489 447 4.04e-05 2875 9 9 1.000 0.003 HPA:042010_03 hpa 1 stomach 1; glandular cells[Uncertain,High] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.10e-05 3415 9 9 1.000 0.003 GO:0032991 CC 1 macromolecular complex 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.19e-05 126 9 5 0.556 0.040 HP:0100705 hp 1 Abnormality of the glial cells 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.41e-05 3443 9 9 1.000 0.003 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.85e-05 2995 9 9 1.000 0.003 HPA:019020_03 hpa 1 kidney; cells in tubules[Uncertain,High] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.87e-05 3 9 2 0.222 0.667 CORUM:2898 cor 1 Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial 1 O75306,O75489 447 5.87e-05 3554 9 9 1.000 0.003 GO:0046483 BP 1 heterocycle metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.94e-05 29 9 5 0.556 0.172 OMIM:252010 omi 1 Complex I Deficiency 1 O75306,O43181,P49821,Q9UI09,O75489 447 5.98e-05 3561 9 9 1.000 0.003 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.79e-05 143 9 5 0.556 0.035 HP:0003128 hp 1 Lactic acidosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 8.06e-05 3681 9 9 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 9.96e-05 72 9 4 0.444 0.056 HP:0001259 hp 1 Coma 1 O75306,O43181,P49821,O75489 447 1.08e-04 153 9 5 0.556 0.033 HP:0011400 hp 1 Abnormal CNS myelination 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.17e-04 4 9 2 0.222 0.500 CORUM:2901 cor 1 Respiratory chain complex I (intermediate IV/310kD), mitochondrial 1 O75306,O75489 447 1.30e-04 3882 9 9 1.000 0.002 GO:0016043 BP 1 cellular component organization 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.51e-04 3948 9 9 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.67e-04 82 9 4 0.444 0.049 HP:0003287 hp 1 Abnormality of mitochondrial metabolism 1 O75306,O43181,P49821,O75489 447 1.75e-04 4013 9 9 1.000 0.002 GO:0071840 BP 1 cellular component organization or biogenesis 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.78e-04 4019 9 9 1.000 0.002 GO:0003824 MF 1 catalytic activity 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.95e-04 5 9 2 0.222 0.400 CORUM:2903 cor 1 Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial 1 O75306,O75489 447 2.17e-04 977 9 6 0.667 0.006 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.26e-04 178 9 5 0.556 0.028 HP:0000597 hp 1 Ophthalmoparesis 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.41e-04 995 9 6 0.667 0.006 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.72e-04 185 9 5 0.556 0.027 HP:0002104 hp 1 Apnea 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.74e-04 93 9 4 0.444 0.043 HP:0012103 hp 1 Abnormality of the mitochondrion 1 O75306,O43181,P49821,O75489 447 3.03e-04 4264 9 9 1.000 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.23e-04 97 9 4 0.444 0.041 HP:0001254 hp 1 Lethargy 1 O75306,O43181,P49821,O75489 447 3.93e-04 102 9 4 0.444 0.039 HP:0003546 hp 1 Exercise intolerance 1 O75306,O43181,P49821,O75489 447 3.99e-04 624 9 5 0.556 0.008 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 4.36e-04 3743 9 9 1.000 0.002 HPA:006020_02 hpa 1 cerebellum; cells in granular layer[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.99e-04 210 9 5 0.556 0.024 HP:0003676 hp 1 Progressive 1 O75306,O43181,P49821,Q9UI09,O75489 447 6.00e-04 4600 9 9 1.000 0.002 GO:0016020 CC 1 membrane 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.56e-04 713 9 5 0.556 0.007 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 7.88e-04 122 9 4 0.444 0.033 HP:0001423 hp 1 X-linked dominant inheritance 1 O75306,O43181,P49821,O75489 447 8.34e-04 234 9 5 0.556 0.021 HP:0000998 hp 1 Hypertrichosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 8.68e-04 236 9 5 0.556 0.021 HP:0012447 hp 1 Abnormal myelination 1 O75306,O43181,P49821,Q9UI09,O75489 447 8.84e-04 2813 9 8 0.889 0.003 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 P51970,Q16718,O75306,O43181,P49821,Q9UI09,O75489,O95182 447 8.86e-04 237 9 5 0.556 0.021 HP:0002793 hp 1 Abnormal pattern of respiration 1 O75306,O43181,P49821,Q9UI09,O75489 447 9.04e-04 238 9 5 0.556 0.021 HP:0001941 hp 1 Acidosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 9.77e-04 129 9 4 0.444 0.031 HP:0002013 hp 1 Vomiting 1 O75306,O43181,P49821,O75489 447 9.77e-04 129 9 4 0.444 0.031 HP:0001943 hp 1 Hypoglycemia 1 O75306,O43181,P49821,O75489 447 1.04e-03 131 9 4 0.444 0.031 HP:0000543 hp 1 Optic disc pallor 1 O75306,O43181,P49821,O75489 447 1.12e-03 249 9 5 0.556 0.020 HP:0004360 hp 1 Abnormality of acid-base homeostasis 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.15e-03 1308 9 6 0.667 0.005 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.26e-03 1329 9 6 0.667 0.005 HPA:021020_12 hpa 1 liver; hepatocytes[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.30e-03 139 9 4 0.444 0.029 HP:0011015 hp 1 Abnormality of blood glucose concentration 1 O75306,O43181,P49821,O75489 447 1.47e-03 2079 9 7 0.778 0.003 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 P51970,Q16718,O75306,O43181,P49821,Q9UI09,O75489 447 1.47e-03 264 9 5 0.556 0.019 HP:0000580 hp 1 Pigmentary retinopathy 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.63e-03 838 9 5 0.556 0.006 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 1.74e-03 150 9 4 0.444 0.027 HP:0001399 hp 1 Hepatic failure 1 O75306,O43181,P49821,O75489 447 1.79e-03 151 9 4 0.444 0.026 HP:0001298 hp 1 Encephalopathy 1 O75306,O43181,P49821,O75489 447 2.04e-03 283 9 5 0.556 0.018 HP:0001332 hp 1 Dystonia 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.25e-03 352 9 3 0.333 0.009 MI:hsa-miR-127-3p mi 1 MI:hsa-miR-127-3p 1 P51970,O95169,O75489 447 2.28e-03 1477 9 6 0.667 0.004 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.28e-03 290 9 5 0.556 0.017 HP:0001629 hp 1 Ventricular septal defect 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.31e-03 1480 9 6 0.667 0.004 HPA:017010_12 hpa 1 heart muscle; myocytes[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.51e-03 296 9 5 0.556 0.017 HP:0010438 hp 1 Abnormality of the ventricular septum 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.54e-03 484 9 4 0.444 0.008 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P51970,Q16718,O43181,Q9UI09 447 2.65e-03 2274 9 7 0.778 0.003 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 P51970,Q16718,O75306,O43181,Q9UI09,O75489,O95182 447 2.69e-03 1521 9 6 0.667 0.004 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.71e-03 301 9 5 0.556 0.017 HP:0002311 hp 1 Incoordination 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.80e-03 170 9 4 0.444 0.024 HP:0004372 hp 1 Reduced consciousness/confusion 1 O75306,O43181,P49821,O75489 447 2.99e-03 173 9 4 0.444 0.023 HP:0001410 hp 1 Decreased liver function 1 O75306,O43181,P49821,O75489 447 3.18e-03 72 9 2 0.222 0.028 GO:0009055 MF 1 electron carrier activity 1 O75306,O75489 447 3.28e-03 1576 9 6 0.667 0.004 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.43e-03 1589 9 6 0.667 0.004 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.47e-03 180 9 4 0.444 0.022 HP:0002376 hp 1 Developmental regression 1 O75306,O43181,P49821,O75489 447 3.64e-03 994 9 5 0.556 0.005 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 3.70e-03 5629 9 9 1.000 0.002 GO:0044444 CC 1 cytoplasmic part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 3.70e-03 322 9 5 0.556 0.016 HP:0001260 hp 1 Dysarthria 1 O75306,O43181,P49821,Q9UI09,O75489 447 3.81e-03 1619 9 6 0.667 0.004 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.84e-03 185 9 4 0.444 0.022 HP:0000618 hp 1 Blindness 1 O75306,O43181,P49821,O75489 447 3.86e-03 325 9 5 0.556 0.015 HP:0007703 hp 1 Abnormality of retinal pigmentation 1 O75306,O43181,P49821,Q9UI09,O75489 447 3.86e-03 540 9 4 0.444 0.007 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 P51970,Q16718,O43181,Q9UI09 447 4.20e-03 331 9 5 0.556 0.015 HP:0002921 hp 1 Abnormality of the cerebrospinal fluid 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.57e-03 344 9 3 0.333 0.009 GO:0005759 CC 1 mitochondrial matrix 1 O75306,O75489,O95182 447 4.59e-03 194 9 4 0.444 0.021 HP:0002017 hp 1 Nausea and vomiting 1 O75306,O43181,P49821,O75489 447 4.74e-03 5787 9 9 1.000 0.002 GO:0044446 CC 1 intracellular organelle part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 4.81e-03 341 9 5 0.556 0.015 HP:0001425 hp 1 Heterogeneous 1 O75306,O43181,P49821,Q9UI09,O75489 447 5.06e-03 1704 9 6 0.667 0.004 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 5.32e-03 1078 9 5 0.556 0.005 HPA:037010_13 hpa 1 small intestine; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 5.45e-03 5877 9 9 1.000 0.002 GO:0044422 CC 1 organelle part 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.98e-03 1756 9 6 0.667 0.003 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 6.23e-03 361 9 5 0.556 0.014 HP:0000508 hp 1 Ptosis 1 O75306,O43181,P49821,Q9UI09,O75489 447 6.48e-03 1782 9 6 0.667 0.003 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 6.49e-03 213 9 4 0.444 0.019 HP:0003487 hp 1 Babinski sign 1 O75306,O43181,P49821,O75489 447 6.59e-03 1787 9 6 0.667 0.003 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 6.70e-03 1133 9 5 0.556 0.004 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 7.07e-03 218 9 4 0.444 0.018 HP:0004302 hp 1 Functional motor problems 1 O75306,O43181,P49821,O75489 447 7.88e-03 5162 9 9 1.000 0.002 HPA:017010_02 hpa 1 heart muscle; myocytes[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 7.94e-03 6128 9 9 1.000 0.001 GO:0044238 BP 1 primary metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 8.28e-03 1863 9 6 0.667 0.003 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 8.34e-03 228 9 4 0.444 0.018 HP:0001639 hp 1 Hypertrophic cardiomyopathy 1 O75306,O43181,P49821,O75489 447 8.48e-03 229 9 4 0.444 0.017 HP:0001272 hp 1 Cerebellar atrophy 1 O75306,O43181,P49821,O75489 447 8.52e-03 387 9 5 0.556 0.013 HP:0001713 hp 1 Abnormality of cardiac ventricle 1 O75306,O43181,P49821,Q9UI09,O75489 447 8.82e-03 390 9 5 0.556 0.013 HP:0001671 hp 1 Abnormality of the cardiac septa 1 O75306,O43181,P49821,Q9UI09,O75489 447 8.85e-03 121 9 2 0.222 0.017 GO:0072593 BP 1 reactive oxygen species metabolic process 1 O43181,O75489 447 9.03e-03 392 9 5 0.556 0.013 HP:0003679 hp 1 Pace of progression 1 O75306,O43181,P49821,Q9UI09,O75489 447 9.61e-03 237 9 4 0.444 0.017 HP:0001265 hp 1 Hyporeflexia 1 O75306,O43181,P49821,O75489 447 9.71e-03 6266 9 9 1.000 0.001 GO:0044763 BP 1 single-organism cellular process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.01e-02 1932 9 6 0.667 0.003 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.01e-02 1932 9 6 0.667 0.003 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.02e-02 6299 9 9 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.08e-02 408 9 5 0.556 0.012 HP:0000648 hp 1 Optic atrophy 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.10e-02 6 9 1 0.111 0.167 GO:0010181 MF 1 FMN binding 1 P49821 447 1.16e-02 5386 9 9 1.000 0.002 HPA:032010_02 hpa 1 salivary gland; glandular cells[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.17e-02 5392 9 9 1.000 0.002 HPA:036010_02 hpa 1 skin 2; epidermal cells[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.18e-02 1986 9 6 0.667 0.003 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.23e-02 420 9 5 0.556 0.012 HP:0100851 hp 1 Abnormal emotion/affect behavior 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.31e-02 1310 9 5 0.556 0.004 HPA:018020_03 hpa 1 hippocampus; neuronal cells[Uncertain,High] 1 P51970,Q16718,O43181,Q9UI09,O75489 447 1.32e-02 6484 9 9 1.000 0.001 GO:0071704 BP 1 organic substance metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.35e-02 260 9 4 0.444 0.015 HP:0007256 hp 1 Abnormal pyramidal signs 1 O75306,O43181,P49821,O75489 447 1.38e-02 431 9 5 0.556 0.012 HP:0001257 hp 1 Spasticity 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.40e-02 2051 9 6 0.667 0.003 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.43e-02 2060 9 6 0.667 0.003 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.45e-02 436 9 5 0.556 0.011 HP:0011362 hp 1 Abnormal hair quantity 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.48e-02 438 9 5 0.556 0.011 HP:0012795 hp 1 Abnormality of the optic disc 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.50e-02 775 9 4 0.444 0.005 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P51970,Q16718,O75306,Q9UI09 447 1.56e-02 2092 9 6 0.667 0.003 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.63e-02 2110 9 6 0.667 0.003 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.64e-02 6642 9 9 1.000 0.001 GO:0008152 BP 1 metabolic process 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.65e-02 3017 9 7 0.778 0.002 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 P51970,Q16718,O75306,P49821,Q9UI09,O75489,O95182 447 1.67e-02 2119 9 6 0.667 0.003 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.67e-02 798 9 4 0.444 0.005 HPA:021010_12 hpa 1 liver; bile duct cells[Supportive,Medium] 1 P51970,O43181,O95169,Q9UI09 447 1.67e-02 798 9 4 0.444 0.005 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P51970,Q16718,O75306,Q9UI09 447 1.67e-02 5612 9 9 1.000 0.002 HPA:023010_01 hpa 1 lymph node; germinal center cells[Uncertain,Low] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.68e-02 3 9 1 0.111 0.333 CORUM:2942 cor 1 Ecsit complex (ECSIT, NDUFS3, NDUFAF1) 1 O75489 447 1.68e-02 3 9 1 0.111 0.333 CORUM:2906 cor 1 Respiratory chain complex I (intermediate II/230kD), mitochondrial 1 O43181 447 1.68e-02 3 9 1 0.111 0.333 CORUM:2938 cor 1 Ecsit complex (ECSIT, NDUFS3, TOM20) 1 O75489 447 1.71e-02 6671 9 9 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 1.72e-02 2130 9 6 0.667 0.003 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.76e-02 2139 9 6 0.667 0.003 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.76e-02 2139 9 6 0.667 0.003 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.80e-02 458 9 5 0.556 0.011 HP:0001251 hp 1 Ataxia 1 O75306,O43181,P49821,Q9UI09,O75489 447 1.81e-02 2151 9 6 0.667 0.003 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.82e-02 2153 9 6 0.667 0.003 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.83e-02 2154 9 6 0.667 0.003 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.85e-02 2159 9 6 0.667 0.003 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.89e-02 2168 9 6 0.667 0.003 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.96e-02 2183 9 6 0.667 0.003 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 1.97e-02 289 9 4 0.444 0.014 HP:0000969 hp 1 Edema 1 O75306,O43181,P49821,O75489 447 1.99e-02 836 9 4 0.444 0.005 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 P51970,Q16718,O43181,Q9UI09 447 1.99e-02 2188 9 6 0.667 0.003 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.06e-02 2202 9 6 0.667 0.003 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.09e-02 2209 9 6 0.667 0.003 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.12e-02 2215 9 6 0.667 0.003 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.18e-02 2227 9 6 0.667 0.003 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.19e-02 479 9 5 0.556 0.010 HP:0001508 hp 1 Failure to thrive 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.19e-02 5781 9 9 1.000 0.002 HPA:006020_01 hpa 1 cerebellum; cells in granular layer[Uncertain,Low] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.19e-02 5782 9 9 1.000 0.002 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.21e-02 480 9 5 0.556 0.010 HP:0001347 hp 1 Hyperreflexia 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.23e-02 481 9 5 0.556 0.010 HP:0000587 hp 1 Abnormality of the optic nerve 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.24e-02 195 9 2 0.222 0.010 GO:0006979 BP 1 response to oxidative stress 1 O75306,Q9UI09 447 2.27e-02 483 9 5 0.556 0.010 HP:0003593 hp 1 Infantile onset 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.31e-02 485 9 5 0.556 0.010 HP:0002093 hp 1 Respiratory insufficiency 1 O75306,O43181,P49821,Q9UI09,O75489 447 2.31e-02 871 9 4 0.444 0.005 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 O75306,O43181,O95169,Q9UI09 447 2.39e-02 13 9 1 0.111 0.077 GO:0051539 MF 1 4 iron, 4 sulfur cluster binding 1 P49821 447 2.40e-02 1499 9 5 0.556 0.003 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 2.43e-02 2271 9 6 0.667 0.003 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.44e-02 2274 9 6 0.667 0.003 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.45e-02 2276 9 6 0.667 0.003 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.47e-02 2279 9 6 0.667 0.003 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.51e-02 2286 9 6 0.667 0.003 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.52e-02 310 9 4 0.444 0.013 HP:0000256 hp 1 Macrocephaly 1 O75306,O43181,P49821,O75489 447 2.52e-02 310 9 4 0.444 0.013 HP:0040194 hp 1 Increased head circumference 1 O75306,O43181,P49821,O75489 447 2.54e-02 3228 9 7 0.778 0.002 HPA:037010_03 hpa 1 small intestine; glandular cells[Uncertain,High] 1 P51970,Q16718,O75306,O43181,Q9UI09,O75489,O95182 447 2.54e-02 2290 9 6 0.667 0.003 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.58e-02 210 9 2 0.222 0.010 GO:0007420 BP 1 brain development 1 O43181,O75489 447 2.61e-02 6993 9 9 1.000 0.001 GO:0005737 CC 1 cytoplasm 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 2.66e-02 2310 9 6 0.667 0.003 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.70e-02 909 9 4 0.444 0.004 HPA:006020_03 hpa 1 cerebellum; cells in granular layer[Uncertain,High] 1 P51970,Q16718,O75489,O95182 447 2.73e-02 331 9 2 0.222 0.006 MI:hsa-miR-493* mi 1 MI:hsa-miR-493* 1 O75306,O95169 447 2.75e-02 15 9 1 0.111 0.067 GO:0051287 MF 1 NAD binding 1 P49821 447 2.75e-02 318 9 4 0.444 0.013 HP:0011017 hp 1 Abnormality of cell physiology 1 O75306,O43181,P49821,O75489 447 2.77e-02 2328 9 6 0.667 0.003 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 2.78e-02 334 9 2 0.222 0.006 MI:hsa-miR-192* mi 1 MI:hsa-miR-192* 1 P51970,O75306 447 2.80e-02 219 9 2 0.222 0.009 GO:0060322 BP 1 head development 1 O43181,O75489 447 2.81e-02 919 9 4 0.444 0.004 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 P51970,Q16718,O75306,O43181 447 2.93e-02 16 9 1 0.111 0.062 GO:0007585 BP 1 respiratory gaseous exchange 1 Q9UI09 447 2.99e-02 1574 9 5 0.556 0.003 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.02e-02 2366 9 6 0.667 0.003 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.07e-02 1583 9 5 0.556 0.003 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.07e-02 1583 9 5 0.556 0.003 HPA:033010_03 hpa 1 seminal vesicle; glandular cells[Uncertain,High] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.17e-02 331 9 4 0.444 0.012 HP:0008872 hp 1 Feeding difficulties in infancy 1 O75306,O43181,P49821,O75489 447 3.20e-02 332 9 4 0.444 0.012 HP:0001315 hp 1 Reduced tendon reflexes 1 O75306,O43181,P49821,O75489 447 3.22e-02 2395 9 6 0.667 0.003 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.23e-02 2397 9 6 0.667 0.003 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.24e-02 333 9 4 0.444 0.012 HP:0001638 hp 1 Cardiomyopathy 1 O75306,O43181,P49821,O75489 447 3.34e-02 336 9 4 0.444 0.012 HP:0011032 hp 1 Abnormality of fluid regulation 1 O75306,O43181,P49821,O75489 447 3.41e-02 1621 9 5 0.556 0.003 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.42e-02 1622 9 5 0.556 0.003 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169 447 3.43e-02 1623 9 5 0.556 0.003 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.44e-02 2425 9 6 0.667 0.002 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.46e-02 376 9 2 0.222 0.005 MI:mmu-miR-341 mi 1 MI:mmu-miR-341 1 P51970,O95169 447 3.47e-02 2429 9 6 0.667 0.002 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.48e-02 19 9 1 0.111 0.053 GO:0051540 MF 1 metal cluster binding 1 P49821 447 3.48e-02 19 9 1 0.111 0.053 GO:0051536 MF 1 iron-sulfur cluster binding 1 P49821 447 3.52e-02 2435 9 6 0.667 0.002 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.66e-02 2454 9 6 0.667 0.002 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.68e-02 2456 9 6 0.667 0.002 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.68e-02 541 9 5 0.556 0.009 HP:0001276 hp 1 Hypertonia 1 O75306,O43181,P49821,Q9UI09,O75489 447 3.70e-02 346 9 4 0.444 0.012 HP:0011014 hp 1 Abnormal glucose homeostasis 1 O75306,O43181,P49821,O75489 447 3.70e-02 2458 9 6 0.667 0.002 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.76e-02 393 9 2 0.222 0.005 MI:rno-miR-352 mi 1 MI:rno-miR-352 1 Q9UI09,O95182 447 3.77e-02 394 9 2 0.222 0.005 MI:hsa-miR-523 mi 1 MI:hsa-miR-523 1 Q16718,O75306 447 3.78e-02 1659 9 5 0.556 0.003 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 3.78e-02 2469 9 6 0.667 0.002 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.84e-02 1002 9 4 0.444 0.004 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q16718,O43181,O95169,Q9UI09 447 3.84e-02 350 9 4 0.444 0.011 HP:0001637 hp 1 Abnormality of the myocardium 1 O75306,O43181,P49821,O75489 447 3.85e-02 2477 9 6 0.667 0.002 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 3.89e-02 1670 9 5 0.556 0.003 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 P51970,Q16718,O75306,O43181,Q9UI09 447 3.90e-02 7 9 1 0.111 0.143 CORUM:2884 cor 1 Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial 1 O75489 447 4.00e-02 2495 9 6 0.667 0.002 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 4.01e-02 2496 9 6 0.667 0.002 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 4.03e-02 22 9 1 0.111 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 O43181 447 4.03e-02 4659 9 8 0.889 0.002 HPA:020020_02 hpa 1 lateral ventricle; neuronal cells[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O95182 447 4.07e-02 554 9 5 0.556 0.009 HP:0011443 hp 1 Abnormality of coordination 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.08e-02 411 9 2 0.222 0.005 MI:hsa-miR-379 mi 1 MI:hsa-miR-379 1 P49821,Q9UI09 447 4.16e-02 557 9 5 0.556 0.009 HP:0000407 hp 1 Sensorineural hearing impairment 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.18e-02 4682 9 8 0.889 0.002 HPA:018020_02 hpa 1 hippocampus; neuronal cells[Uncertain,Medium] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09,O75489,O95182 447 4.29e-02 561 9 5 0.556 0.009 HP:0000479 hp 1 Abnormality of the retina 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.43e-02 430 9 2 0.222 0.005 MI:hsa-miR-450b-3p mi 1 MI:hsa-miR-450b-3p 1 O75306,O75489 447 4.45e-02 431 9 2 0.222 0.005 MI:hsa-miR-29a* mi 1 MI:hsa-miR-29a* 1 O75306,O43181 447 4.46e-02 2547 9 6 0.667 0.002 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 P51970,Q16718,O75306,O43181,O95169,Q9UI09 447 4.58e-02 570 9 5 0.556 0.009 HP:0003812 hp 1 Phenotypic variability 1 O75306,O43181,P49821,Q9UI09,O75489 447 4.73e-02 446 9 2 0.222 0.004 MI:hsa-miR-654-5p mi 1 MI:hsa-miR-654-5p 1 P51970,P49821 447 4.75e-02 26 9 1 0.111 0.038 GO:0051591 BP 1 response to cAMP 1 O43181 447 4.87e-02 453 9 2 0.222 0.004 MI:hsa-miR-873 mi 1 MI:hsa-miR-873 1 Q16718,O95169 447 4.87e-02 453 9 2 0.222 0.004 MI:mmu-miR-700 mi 1 MI:mmu-miR-700 1 P49821,O75489 447 4.89e-02 454 9 2 0.222 0.004 MI:hsa-miR-30d* mi 1 MI:hsa-miR-30d* 1 O75306,O95169 447 4.95e-02 457 9 2 0.222 0.004 MI:mmu-miR-713 mi 1 MI:mmu-miR-713 1 O75306,O95169 447 4.97e-02 1765 9 5 0.556 0.003 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P51970,Q16718,O43181,O95169,Q9UI09 447 5.00e-02 15 9 3 0.333 0.200 OMIM:256000 omi 1 LEIGH SYNDROME; LS;;NECROTIZING ENCEPHALOPATHY, INFANTILE SUBACUTE, OF LEIGH; SNELEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX II DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX III DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX IV DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX V DEFICIENCY, INCLUDED 1 O43181,Q9UI09,O75489 447 5.00e-02 1078 9 4 0.444 0.004 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 P51970,Q16718,O75306,Q9UI09 447 5.00e-02 7517 9 9 1.000 0.001 GO:0043229 CC 1 intracellular organelle 1 P51970,Q16718,O75306,O43181,O95169,P49821,Q9UI09,O75489,O95182 447 5.00e-02 9 9 1 0.111 0.111 CORUM:2919 cor 1 Respiratory chain complex I (gamma subunit) mitochondrial 1 P51970 447 5.00e-02 21 9 2 0.222 0.095 TF:M07087_1 tf 1 Factor: Elf-1; motif: NRANCMGGAAGTG; match class: 1 1 O75306,Q9UI09 448 3.01e-16 8 6 5 0.833 0.625 GO:0031588 CC 1 nucleotide-activated protein kinase complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 7.75e-15 27 6 6 1.000 0.222 REAC:380972 rea 1 Energy dependent regulation of mTOR by LKB1-AMPK 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.47e-14 26 6 6 1.000 0.231 KEGG:04710 keg 1 Circadian rhythm 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.38e-14 9 6 5 0.833 0.556 REAC:2151209 rea 1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 7.23e-14 38 6 6 1.000 0.158 REAC:165159 rea 1 mTOR signalling 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 8.54e-14 39 6 6 1.000 0.154 REAC:109703 rea 1 PKB-mediated events 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.55e-13 5 6 4 0.667 0.800 GO:0004679 MF 1 AMP-activated protein kinase activity 1 O43741,Q13131,P54646,P54619 448 2.16e-12 65 6 6 1.000 0.092 REAC:109704 rea 1 PI3K Cascade 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.32e-12 57 6 6 1.000 0.105 KEGG:04213 keg 1 Longevity regulating pathway - multiple species 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.38e-12 66 6 6 1.000 0.091 REAC:1632852 rea 1 Macroautophagy 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.59e-12 58 6 6 1.000 0.103 KEGG:04920 keg 1 Adipocytokine signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.18e-12 139 6 6 1.000 0.043 GO:1901796 BP 1 regulation of signal transduction by p53 class mediator 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.80e-12 66 6 6 1.000 0.091 KEGG:05410 keg 1 Hypertrophic cardiomyopathy (HCM) 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.28e-12 79 6 6 1.000 0.076 REAC:5628897 rea 1 TP53 Regulates Metabolic Genes 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.23e-11 86 6 6 1.000 0.070 REAC:6804756 rea 1 Regulation of TP53 Activity through Phosphorylation 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.02e-11 180 6 6 1.000 0.033 GO:0007050 BP 1 cell cycle arrest 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.41e-11 83 6 6 1.000 0.072 KEGG:04211 keg 1 Longevity regulating pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.71e-11 89 6 6 1.000 0.067 KEGG:04922 keg 1 Glucagon signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.20e-11 203 6 6 1.000 0.030 GO:0016236 BP 1 macroautophagy 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.60e-11 206 6 6 1.000 0.029 GO:0072331 BP 1 signal transduction by p53 class mediator 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.92e-11 96 6 6 1.000 0.062 KEGG:04931 keg 1 Insulin resistance 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.15e-10 107 6 6 1.000 0.056 KEGG:04152 keg 1 AMPK signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.37e-10 81 6 5 0.833 0.062 GO:1902911 CC 1 protein kinase complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 1.45e-10 111 6 6 1.000 0.054 KEGG:04068 keg 1 FoxO signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.50e-10 20 6 4 0.667 0.200 GO:0006110 BP 1 regulation of glycolytic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.45e-10 121 6 6 1.000 0.050 KEGG:04910 keg 1 Insulin signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.00e-10 125 6 6 1.000 0.048 KEGG:04932 keg 1 Non-alcoholic fatty liver disease (NAFLD) 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.74e-10 150 6 6 1.000 0.040 REAC:5633007 rea 1 Regulation of TP53 Activity 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.81e-10 130 6 6 1.000 0.046 KEGG:04921 keg 1 Oxytocin signaling pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.42e-10 51 6 5 0.833 0.098 REAC:1592230 rea 1 Mitochondrial biogenesis 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 5.42e-10 27 6 4 0.667 0.148 GO:0043470 BP 1 regulation of carbohydrate catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 7.87e-10 57 6 5 0.833 0.088 REAC:1445148 rea 1 Translocation of GLUT4 to the plasma membrane 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 9.56e-10 340 6 6 1.000 0.018 GO:0006914 BP 1 autophagy 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 9.71e-10 31 6 4 0.667 0.129 GO:1903578 BP 1 regulation of ATP metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.71e-10 31 6 4 0.667 0.129 GO:0009118 BP 1 regulation of nucleoside metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.76e-09 376 6 6 1.000 0.016 GO:0045786 BP 1 negative regulation of cell cycle 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.54e-09 39 6 4 0.667 0.103 GO:0051193 BP 1 regulation of cofactor metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.54e-09 39 6 4 0.667 0.103 GO:0051196 BP 1 regulation of coenzyme metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 5.99e-09 48 6 4 0.667 0.083 GO:0043467 BP 1 regulation of generation of precursor metabolites and energy 1 Q9UGJ0,Q13131,P54646,P54619 448 6.52e-09 49 6 4 0.667 0.082 GO:0006096 BP 1 glycolytic process 1 Q9UGJ0,Q13131,P54646,P54619 448 6.52e-09 240 6 6 1.000 0.025 REAC:112399 rea 1 IRS-mediated signalling 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.69e-09 241 6 6 1.000 0.025 REAC:2428928 rea 1 IRS-related events triggered by IGF1R 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.69e-09 241 6 6 1.000 0.025 REAC:2428924 rea 1 IGF1R signaling cascade 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.86e-09 242 6 6 1.000 0.025 REAC:74751 rea 1 Insulin receptor signalling cascade 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.86e-09 242 6 6 1.000 0.025 REAC:2404192 rea 1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.09e-09 50 6 4 0.667 0.080 GO:0006757 BP 1 ATP generation from ADP 1 Q9UGJ0,Q13131,P54646,P54619 448 8.33e-09 52 6 4 0.667 0.077 GO:0046031 BP 1 ADP metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.73e-09 54 6 4 0.667 0.074 GO:0009179 BP 1 purine ribonucleoside diphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.73e-09 54 6 4 0.667 0.074 GO:0009135 BP 1 purine nucleoside diphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.99e-09 9 6 3 0.500 0.333 GO:0006853 BP 1 carnitine shuttle 1 Q9UGJ0,O43741,P54646 448 1.13e-08 56 6 4 0.667 0.071 GO:0006165 BP 1 nucleoside diphosphate phosphorylation 1 Q9UGJ0,Q13131,P54646,P54619 448 1.13e-08 56 6 4 0.667 0.071 GO:0009185 BP 1 ribonucleoside diphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.14e-08 263 6 6 1.000 0.023 REAC:74752 rea 1 Signaling by Insulin receptor 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.21e-08 57 6 4 0.667 0.070 GO:0046939 BP 1 nucleotide phosphorylation 1 Q9UGJ0,Q13131,P54646,P54619 448 1.71e-08 62 6 4 0.667 0.065 GO:0009132 BP 1 nucleoside diphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.98e-08 216 6 5 0.833 0.023 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 2.50e-08 68 6 4 0.667 0.059 GO:0046890 BP 1 regulation of lipid biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 3.40e-08 13 6 3 0.500 0.231 GO:1902001 BP 1 fatty acid transmembrane transport 1 Q9UGJ0,O43741,P54646 448 3.93e-08 76 6 4 0.667 0.053 GO:0006090 BP 1 pyruvate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.15e-08 77 6 4 0.667 0.052 GO:0006109 BP 1 regulation of carbohydrate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.57e-08 331 6 6 1.000 0.018 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.20e-08 679 6 6 1.000 0.009 GO:0051726 BP 1 regulation of cell cycle 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.50e-08 86 6 4 0.667 0.047 GO:0019362 BP 1 pyridine nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 6.50e-08 86 6 4 0.667 0.047 GO:0046496 BP 1 nicotinamide nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 6.82e-08 87 6 4 0.667 0.046 GO:1900542 BP 1 regulation of purine nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.19e-08 8 6 3 0.500 0.375 REAC:163680 rea 1 AMPK inhibits chREBP transcriptional activation activity 1 Q9UGJ0,O43741,P54646 448 9.33e-08 94 6 4 0.667 0.043 GO:0006733 BP 1 oxidoreduction coenzyme metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.74e-08 95 6 4 0.667 0.042 GO:0006140 BP 1 regulation of nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.02e-07 378 6 6 1.000 0.016 REAC:2262752 rea 1 Cellular responses to stress 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.06e-07 97 6 4 0.667 0.041 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.06e-07 97 6 4 0.667 0.041 GO:0072524 BP 1 pyridine-containing compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.15e-07 19 6 3 0.500 0.158 GO:0042304 BP 1 regulation of fatty acid biosynthetic process 1 Q9UGJ0,O43741,P54646 448 1.30e-07 102 6 4 0.667 0.039 GO:0016052 BP 1 carbohydrate catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.83e-07 22 6 3 0.500 0.136 GO:0032365 BP 1 intracellular lipid transport 1 Q9UGJ0,O43741,P54646 448 1.97e-07 10 6 3 0.500 0.300 REAC:200425 rea 1 Import of palmitoyl-CoA into the mitochondrial matrix 1 Q9UGJ0,O43741,P54646 448 2.33e-07 353 6 5 0.833 0.014 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 3.88e-07 28 6 3 0.500 0.107 GO:0015909 BP 1 long-chain fatty acid transport 1 Q9UGJ0,O43741,P54646 448 4.74e-07 952 6 6 1.000 0.006 GO:0022402 BP 1 cell cycle process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.67e-07 147 6 4 0.667 0.027 GO:0019216 BP 1 regulation of lipid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646 448 5.87e-07 32 6 3 0.500 0.094 GO:1903825 BP 1 organic acid transmembrane transport 1 Q9UGJ0,O43741,P54646 448 5.87e-07 32 6 3 0.500 0.094 GO:1905039 BP 1 carboxylic acid transmembrane transport 1 Q9UGJ0,O43741,P54646 448 7.48e-07 1027 6 6 1.000 0.006 GO:1902531 BP 1 regulation of intracellular signal transduction 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 9.19e-07 37 6 3 0.500 0.081 GO:0015908 BP 1 fatty acid transport 1 Q9UGJ0,O43741,P54646 448 9.92e-07 472 6 5 0.833 0.011 GO:0004672 MF 1 protein kinase activity 1 Q9Y478,O43741,Q13131,P54646,P54619 448 1.22e-06 178 6 4 0.667 0.022 GO:0046034 BP 1 ATP metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.32e-06 1128 6 6 1.000 0.005 GO:0007049 BP 1 cell cycle 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.55e-06 189 6 4 0.667 0.021 GO:0009205 BP 1 purine ribonucleoside triphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.59e-06 190 6 4 0.667 0.021 GO:0009199 BP 1 ribonucleoside triphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.68e-06 45 6 3 0.500 0.067 GO:0019217 BP 1 regulation of fatty acid metabolic process 1 Q9UGJ0,O43741,P54646 448 1.69e-06 193 6 4 0.667 0.021 GO:0009144 BP 1 purine nucleoside triphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.99e-06 201 6 4 0.667 0.020 GO:0009126 BP 1 purine nucleoside monophosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.99e-06 201 6 4 0.667 0.020 GO:0009167 BP 1 purine ribonucleoside monophosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.07e-06 203 6 4 0.667 0.020 GO:0009161 BP 1 ribonucleoside monophosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.18e-06 628 6 6 1.000 0.010 REAC:212436 rea 1 Generic Transcription Pathway 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.19e-06 206 6 4 0.667 0.019 GO:0009123 BP 1 nucleoside monophosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.37e-06 210 6 4 0.667 0.019 GO:0009141 BP 1 nucleoside triphosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.56e-06 214 6 4 0.667 0.019 GO:0006732 BP 1 coenzyme metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.72e-06 578 6 5 0.833 0.009 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 Q9Y478,O43741,Q13131,P54646,P54619 448 3.98e-06 624 6 5 0.833 0.008 GO:1990234 CC 1 transferase complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 4.04e-06 240 6 4 0.667 0.017 GO:0046128 BP 1 purine ribonucleoside metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.18e-06 630 6 5 0.833 0.008 GO:0016301 MF 1 kinase activity 1 Q9Y478,O43741,Q13131,P54646,P54619 448 4.24e-06 61 6 3 0.500 0.049 GO:1990542 BP 1 mitochondrial transmembrane transport 1 Q9UGJ0,O43741,P54646 448 4.25e-06 243 6 4 0.667 0.016 GO:0042278 BP 1 purine nucleoside metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.49e-06 314 6 5 0.833 0.016 REAC:1852241 rea 1 Organelle biogenesis and maintenance 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 4.67e-06 63 6 3 0.500 0.048 GO:0015718 BP 1 monocarboxylic acid transport 1 Q9UGJ0,O43741,P54646 448 4.83e-06 251 6 4 0.667 0.016 GO:0009119 BP 1 ribonucleoside metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.88e-06 650 6 5 0.833 0.008 GO:0019752 BP 1 carboxylic acid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 5.14e-06 65 6 3 0.500 0.046 GO:0006633 BP 1 fatty acid biosynthetic process 1 Q9UGJ0,O43741,P54646 448 5.15e-06 6 6 2 0.333 0.333 GO:0004691 MF 1 cAMP-dependent protein kinase activity 1 Q13131,P54619 448 5.15e-06 6 6 2 0.333 0.333 GO:0055089 BP 1 fatty acid homeostasis 1 Q13131,P54646 448 5.15e-06 6 6 2 0.333 0.333 GO:0008603 MF 1 cAMP-dependent protein kinase regulator activity 1 Q9UGJ0,P54619 448 5.31e-06 257 6 4 0.667 0.016 GO:0006091 BP 1 generation of precursor metabolites and energy 1 Q9UGJ0,Q13131,P54646,P54619 448 6.18e-06 267 6 4 0.667 0.015 GO:0051186 BP 1 cofactor metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 6.72e-06 71 6 3 0.500 0.042 GO:0098656 BP 1 anion transmembrane transport 1 Q9UGJ0,O43741,P54646 448 7.16e-06 277 6 4 0.667 0.014 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 7.58e-06 281 6 4 0.667 0.014 GO:0009116 BP 1 nucleoside metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 8.32e-06 1533 6 6 1.000 0.004 GO:0035556 BP 1 intracellular signal transduction 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 8.62e-06 729 6 5 0.833 0.007 GO:0043436 BP 1 oxoacid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 9.22e-06 739 6 5 0.833 0.007 GO:0006082 BP 1 organic acid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 9.60e-06 8 6 2 0.333 0.250 GO:0045821 BP 1 positive regulation of glycolytic process 1 Q13131,P54646 448 9.60e-06 8 6 2 0.333 0.250 GO:0035174 MF 1 histone serine kinase activity 1 Q13131,P54646 448 9.60e-06 8 6 2 0.333 0.250 GO:0004690 MF 1 cyclic nucleotide-dependent protein kinase activity 1 Q13131,P54619 448 9.60e-06 8 6 2 0.333 0.250 GO:2000505 BP 1 regulation of energy homeostasis 1 Q13131,P54646 448 9.70e-06 299 6 4 0.667 0.013 GO:1901657 BP 1 glycosyl compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.71e-06 1573 6 6 1.000 0.004 GO:0009966 BP 1 regulation of signal transduction 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.02e-05 303 6 4 0.667 0.013 GO:0009150 BP 1 purine ribonucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.03e-05 755 6 5 0.833 0.007 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 Q9Y478,O43741,Q13131,P54646,P54619 448 1.04e-05 304 6 4 0.667 0.013 GO:0044283 BP 1 small molecule biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 1.08e-05 307 6 4 0.667 0.013 GO:0009259 BP 1 ribonucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.23e-05 9 6 2 0.333 0.222 GO:0051197 BP 1 positive regulation of coenzyme metabolic process 1 Q13131,P54646 448 1.23e-05 9 6 2 0.333 0.222 GO:0051194 BP 1 positive regulation of cofactor metabolic process 1 Q13131,P54646 448 1.25e-05 319 6 4 0.667 0.013 GO:0019693 BP 1 ribose phosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.33e-05 324 6 4 0.667 0.012 GO:0006163 BP 1 purine nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.33e-05 324 6 4 0.667 0.012 GO:0005975 BP 1 carbohydrate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.42e-05 329 6 4 0.667 0.012 GO:0004674 MF 1 protein serine/threonine kinase activity 1 O43741,Q13131,P54646,P54619 448 1.50e-05 1691 6 6 1.000 0.004 GO:0010646 BP 1 regulation of cell communication 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.71e-05 1728 6 6 1.000 0.003 GO:0023051 BP 1 regulation of signaling 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.81e-05 350 6 4 0.667 0.011 GO:0009894 BP 1 regulation of catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.81e-05 350 6 4 0.667 0.011 GO:0072521 BP 1 purine-containing compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.88e-05 11 6 2 0.333 0.182 GO:0097009 BP 1 energy homeostasis 1 Q13131,P54646 448 1.89e-05 100 6 3 0.500 0.030 GO:0072330 BP 1 monocarboxylic acid biosynthetic process 1 Q9UGJ0,O43741,P54646 448 2.19e-05 367 6 4 0.667 0.011 GO:0008610 BP 1 lipid biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 2.26e-05 12 6 2 0.333 0.167 GO:0045979 BP 1 positive regulation of nucleoside metabolic process 1 Q13131,P54646 448 2.26e-05 12 6 2 0.333 0.167 GO:1903580 BP 1 positive regulation of ATP metabolic process 1 Q13131,P54646 448 2.38e-05 108 6 3 0.500 0.028 GO:0010565 BP 1 regulation of cellular ketone metabolic process 1 Q9UGJ0,O43741,P54646 448 2.73e-05 388 6 4 0.667 0.010 GO:0009117 BP 1 nucleotide metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 3.02e-05 398 6 4 0.667 0.010 GO:0006753 BP 1 nucleoside phosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.45e-05 133 6 3 0.500 0.023 GO:0015849 BP 1 organic acid transport 1 Q9UGJ0,O43741,P54646 448 4.45e-05 133 6 3 0.500 0.023 GO:0046942 BP 1 carboxylic acid transport 1 Q9UGJ0,O43741,P54646 448 4.83e-05 1033 6 5 0.833 0.005 GO:1902494 CC 1 catalytic complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 4.90e-05 450 6 4 0.667 0.009 GO:0055086 BP 1 nucleobase-containing small molecule metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 5.23e-05 18 6 2 0.333 0.111 GO:0035173 MF 1 histone kinase activity 1 Q13131,P54646 448 5.41e-05 142 6 3 0.500 0.021 GO:0042180 BP 1 cellular ketone metabolic process 1 Q9UGJ0,O43741,P54646 448 5.53e-05 2101 6 6 1.000 0.003 GO:0048583 BP 1 regulation of response to stimulus 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.53e-05 143 6 3 0.500 0.021 GO:0006869 BP 1 lipid transport 1 Q9UGJ0,O43741,P54646 448 5.63e-05 522 6 5 0.833 0.010 REAC:199991 rea 1 Membrane Trafficking 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 5.69e-05 1068 6 5 0.833 0.005 GO:0006468 BP 1 protein phosphorylation 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 6.50e-05 20 6 2 0.333 0.100 GO:0055081 BP 1 anion homeostasis 1 Q13131,P54646 448 6.54e-05 484 6 4 0.667 0.008 GO:0042327 BP 1 positive regulation of phosphorylation 1 Q9UGJ0,Q13131,P54646,P54619 448 7.18e-05 21 6 2 0.333 0.095 GO:0042149 BP 1 cellular response to glucose starvation 1 Q13131,P54646 448 7.23e-05 549 6 5 0.833 0.009 REAC:5653656 rea 1 Vesicle-mediated transport 1 Q9UGJ0,Q9Y478,O43741,P54646,P54619 448 8.33e-05 164 6 3 0.500 0.018 GO:0010876 BP 1 lipid localization 1 Q9UGJ0,O43741,P54646 448 8.64e-05 23 6 2 0.333 0.087 GO:0043531 MF 1 ADP binding 1 Q9UGJ0,P54619 448 9.11e-05 169 6 3 0.500 0.018 GO:0016053 BP 1 organic acid biosynthetic process 1 Q9UGJ0,O43741,P54646 448 9.11e-05 169 6 3 0.500 0.018 GO:0046394 BP 1 carboxylic acid biosynthetic process 1 Q9UGJ0,O43741,P54646 448 9.28e-05 529 6 4 0.667 0.008 GO:0045937 BP 1 positive regulation of phosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 9.28e-05 529 6 4 0.667 0.008 GO:0010562 BP 1 positive regulation of phosphorus metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.20e-04 27 6 2 0.333 0.074 GO:0032007 BP 1 negative regulation of TOR signaling 1 Q13131,P54646 448 1.26e-04 572 6 4 0.667 0.007 GO:0044712 BP 1 single-organism catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.31e-04 1266 6 5 0.833 0.004 GO:0016310 BP 1 phosphorylation 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 1.33e-04 2432 6 6 1.000 0.002 GO:0048523 BP 1 negative regulation of cellular process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.48e-04 30 6 2 0.333 0.067 GO:0045913 BP 1 positive regulation of carbohydrate metabolic process 1 Q13131,P54646 448 1.57e-04 203 6 3 0.500 0.015 GO:0006631 BP 1 fatty acid metabolic process 1 Q9UGJ0,O43741,P54646 448 1.68e-04 2529 6 6 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.69e-04 1333 6 5 0.833 0.004 GO:0044281 BP 1 small molecule metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 1.74e-04 210 6 3 0.500 0.014 GO:0015711 BP 1 organic anion transport 1 Q9UGJ0,O43741,P54646 448 1.88e-04 633 6 4 0.667 0.006 GO:0044255 BP 1 cellular lipid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646 448 1.97e-04 219 6 3 0.500 0.014 GO:0006839 BP 1 mitochondrial transport 1 Q9UGJ0,O43741,P54646 448 2.07e-04 2618 6 6 1.000 0.002 GO:0048519 BP 1 negative regulation of biological process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.14e-04 94 6 3 0.500 0.032 REAC:163685 rea 1 Integration of energy metabolism 1 Q9UGJ0,O43741,P54646 448 2.40e-04 674 6 4 0.667 0.006 GO:0019637 BP 1 organophosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.52e-04 39 6 2 0.333 0.051 GO:0016126 BP 1 sterol biosynthetic process 1 Q9UGJ0,Q13131 448 2.53e-04 2707 6 6 1.000 0.002 GO:0005829 CC 1 cytosol 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.99e-04 252 6 3 0.500 0.012 GO:0045860 BP 1 positive regulation of protein kinase activity 1 Q9UGJ0,Q13131,P54619 448 3.43e-04 264 6 3 0.500 0.011 GO:0006820 BP 1 anion transport 1 Q9UGJ0,O43741,P54646 448 3.79e-04 273 6 3 0.500 0.011 GO:0033674 BP 1 positive regulation of kinase activity 1 Q9UGJ0,Q13131,P54619 448 3.84e-04 760 6 4 0.667 0.005 GO:0042325 BP 1 regulation of phosphorylation 1 Q9UGJ0,Q13131,P54646,P54619 448 3.86e-04 1485 6 6 1.000 0.004 REAC:74160 rea 1 Gene Expression 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.94e-04 765 6 4 0.667 0.005 GO:0006629 BP 1 lipid metabolic process 1 Q9UGJ0,O43741,Q13131,P54646 448 3.99e-04 49 6 2 0.333 0.041 GO:1900544 BP 1 positive regulation of purine nucleotide metabolic process 1 Q13131,P54646 448 3.99e-04 49 6 2 0.333 0.041 GO:0045981 BP 1 positive regulation of nucleotide metabolic process 1 Q13131,P54646 448 4.08e-04 2931 6 6 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.64e-04 798 6 4 0.667 0.005 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.73e-04 3004 6 6 1.000 0.002 GO:0007165 BP 1 signal transduction 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.41e-04 57 6 2 0.333 0.035 GO:0042752 BP 1 regulation of circadian rhythm 1 Q13131,P54646 448 5.50e-04 1575 6 6 1.000 0.004 REAC:162582 rea 1 Signal Transduction 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.79e-04 1715 6 5 0.833 0.003 GO:0016740 MF 1 transferase activity 1 Q9Y478,O43741,Q13131,P54646,P54619 448 5.80e-04 59 6 2 0.333 0.034 GO:0032006 BP 1 regulation of TOR signaling 1 Q13131,P54646 448 5.96e-04 851 6 4 0.667 0.005 GO:0044711 BP 1 single-organism biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 6.00e-04 60 6 2 0.333 0.033 GO:0010508 BP 1 positive regulation of autophagy 1 Q13131,P54646 448 6.30e-04 1745 6 5 0.833 0.003 GO:0009893 BP 1 positive regulation of metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 6.51e-04 3168 6 6 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 6.93e-04 885 6 4 0.667 0.005 GO:0019220 BP 1 regulation of phosphate metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 7.26e-04 66 6 2 0.333 0.030 GO:0009267 BP 1 cellular response to starvation 1 Q13131,P54646 448 7.30e-04 897 6 4 0.667 0.004 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 7.48e-04 67 6 2 0.333 0.030 GO:0031929 BP 1 TOR signaling 1 Q13131,P54646 448 7.76e-04 3262 6 6 1.000 0.002 GO:0007154 BP 1 cell communication 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.78e-04 3263 6 6 1.000 0.002 GO:0019222 BP 1 regulation of metabolic process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.85e-04 3268 6 6 1.000 0.002 GO:0044700 BP 1 single organism signaling 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.92e-04 1 6 1 0.167 1.000 GO:0046317 BP 1 regulation of glucosylceramide biosynthetic process 1 Q13131 448 7.92e-04 1 6 1 0.167 1.000 GO:0046318 BP 1 negative regulation of glucosylceramide biosynthetic process 1 Q13131 448 7.93e-04 69 6 2 0.333 0.029 GO:0055088 BP 1 lipid homeostasis 1 Q13131,P54646 448 7.93e-04 3274 6 6 1.000 0.002 GO:0023052 BP 1 signaling 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 7.97e-04 31 6 2 0.333 0.065 KEGG:04140 keg 1 Autophagy 1 Q13131,P54646 448 8.39e-04 1851 6 5 0.833 0.003 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 8.40e-04 71 6 2 0.333 0.028 GO:0016125 BP 1 sterol metabolic process 1 Q9UGJ0,Q13131 448 8.63e-04 72 6 2 0.333 0.028 GO:0042594 BP 1 response to starvation 1 Q13131,P54646 448 9.37e-04 75 6 2 0.333 0.027 GO:0006694 BP 1 steroid biosynthetic process 1 Q9UGJ0,Q13131 448 1.01e-03 1923 6 5 0.833 0.003 GO:0006793 BP 1 phosphorus metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 1.07e-03 80 6 2 0.333 0.025 GO:0033500 BP 1 carbohydrate homeostasis 1 Q13131,P54646 448 1.07e-03 80 6 2 0.333 0.025 GO:0042593 BP 1 glucose homeostasis 1 Q13131,P54646 448 1.08e-03 390 6 3 0.500 0.008 GO:0051347 BP 1 positive regulation of transferase activity 1 Q9UGJ0,Q13131,P54619 448 1.15e-03 83 6 2 0.333 0.024 GO:0031669 BP 1 cellular response to nutrient levels 1 Q13131,P54646 448 1.18e-03 402 6 3 0.500 0.007 GO:0045859 BP 1 regulation of protein kinase activity 1 Q9UGJ0,Q13131,P54619 448 1.31e-03 416 6 3 0.500 0.007 GO:0034220 BP 1 ion transmembrane transport 1 Q9UGJ0,O43741,P54646 448 1.31e-03 3561 6 6 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.31e-03 3561 6 6 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.31e-03 3561 6 6 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.38e-03 91 6 2 0.333 0.022 GO:0031668 BP 1 cellular response to extracellular stimulus 1 Q13131,P54646 448 1.53e-03 439 6 3 0.500 0.007 GO:0043549 BP 1 regulation of kinase activity 1 Q9UGJ0,Q13131,P54619 448 1.53e-03 2096 6 5 0.833 0.002 GO:0043234 CC 1 protein complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 1.56e-03 97 6 2 0.333 0.021 GO:0007623 BP 1 circadian rhythm 1 Q13131,P54646 448 1.58e-03 2 6 1 0.167 0.500 GO:0099004 BP 1 calmodulin dependent kinase signaling pathway 1 Q13131 448 1.58e-03 2 6 1 0.167 0.500 GO:0006679 BP 1 glucosylceramide biosynthetic process 1 Q13131 448 1.58e-03 2 6 1 0.167 0.500 GO:0046476 BP 1 glycosylceramide biosynthetic process 1 Q13131 448 1.58e-03 2 6 1 0.167 0.500 GO:0061762 BP 1 CAMKK-AMPK signaling cascade 1 Q13131 448 1.73e-03 102 6 2 0.333 0.020 GO:1901617 BP 1 organic hydroxy compound biosynthetic process 1 Q9UGJ0,Q13131 448 1.74e-03 459 6 3 0.500 0.007 GO:0001934 BP 1 positive regulation of protein phosphorylation 1 Q9UGJ0,Q13131,P54619 448 1.81e-03 3755 6 6 1.000 0.002 GO:0051716 BP 1 cellular response to stimulus 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.94e-03 108 6 2 0.333 0.019 GO:0031667 BP 1 response to nutrient levels 1 Q13131,P54646 448 2.06e-03 201 6 3 0.500 0.015 REAC:535734 rea 1 Fatty acid, triacylglycerol, and ketone body metabolism 1 Q9UGJ0,O43741,P54646 448 2.08e-03 112 6 2 0.333 0.018 GO:0019887 MF 1 protein kinase regulator activity 1 Q9UGJ0,P54619 448 2.27e-03 2275 6 5 0.833 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 2.27e-03 2275 6 5 0.833 0.002 GO:0036211 BP 1 protein modification process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 2.31e-03 118 6 2 0.333 0.017 GO:0048511 BP 1 rhythmic process 1 Q13131,P54646 448 2.35e-03 119 6 2 0.333 0.017 GO:0009991 BP 1 response to extracellular stimulus 1 Q13131,P54646 448 2.35e-03 119 6 2 0.333 0.017 GO:0071496 BP 1 cellular response to external stimulus 1 Q13131,P54646 448 2.37e-03 3 6 1 0.167 0.333 GO:0090155 BP 1 negative regulation of sphingolipid biosynthetic process 1 Q13131 448 2.37e-03 3 6 1 0.167 0.333 GO:0045542 BP 1 positive regulation of cholesterol biosynthetic process 1 Q13131 448 2.37e-03 3 6 1 0.167 0.333 GO:1900060 BP 1 negative regulation of ceramide biosynthetic process 1 Q13131 448 2.55e-03 124 6 2 0.333 0.016 GO:0019207 MF 1 kinase regulator activity 1 Q9UGJ0,P54619 448 2.63e-03 529 6 3 0.500 0.006 GO:0055085 BP 1 transmembrane transport 1 Q9UGJ0,O43741,P54646 448 2.82e-03 1 6 1 0.167 1.000 OMIM:600858 omi 1 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6; CMH6 1 Q9UGJ0 448 2.82e-03 1 6 1 0.167 1.000 OMIM:194200 omi 1 WOLFF-PARKINSON-WHITE SYNDROME;;WPW SYNDROMEPREEXCITATION SYNDROME, INCLUDED;;ACCESSORY ATRIOVENTRICULAR PATHWAYS, INCLUDED 1 Q9UGJ0 448 2.82e-03 1 6 1 0.167 1.000 OMIM:261740 omi 1 GLYCOGEN STORAGE DISEASE OF HEART, LETHAL CONGENITAL;;PHOSPHORYLASE KINASE DEFICIENCY OF HEART;;GLYCOGEN STORAGE DISEASE OF HEART 1 Q9UGJ0 448 2.95e-03 1290 6 4 0.667 0.003 GO:1901575 BP 1 organic substance catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.97e-03 134 6 2 0.333 0.015 GO:0048871 BP 1 multicellular organismal homeostasis 1 Q13131,P54646 448 3.04e-03 2417 6 5 0.833 0.002 GO:0043412 BP 1 macromolecule modification 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 3.17e-03 4 6 1 0.167 0.250 GO:0008607 MF 1 phosphorylase kinase regulator activity 1 Q9UGJ0 448 3.17e-03 4 6 1 0.167 0.250 GO:0090205 BP 1 positive regulation of cholesterol metabolic process 1 Q13131 448 3.24e-03 140 6 2 0.333 0.014 GO:0008202 BP 1 steroid metabolic process 1 Q9UGJ0,Q13131 448 3.33e-03 574 6 3 0.500 0.005 GO:1902582 BP 1 single-organism intracellular transport 1 Q9UGJ0,O43741,P54646 448 3.38e-03 577 6 3 0.500 0.005 GO:0051338 BP 1 regulation of transferase activity 1 Q9UGJ0,Q13131,P54619 448 3.63e-03 1362 6 4 0.667 0.003 GO:0009056 BP 1 catabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 3.96e-03 5 6 1 0.167 0.200 GO:0006678 BP 1 glucosylceramide metabolic process 1 Q13131 448 3.96e-03 5 6 1 0.167 0.200 GO:0016208 MF 1 AMP binding 1 P54619 448 3.96e-03 5 6 1 0.167 0.200 GO:0035404 BP 1 histone-serine phosphorylation 1 P54646 448 4.00e-03 2560 6 5 0.833 0.002 GO:0044710 BP 1 single-organism metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 4.41e-03 4356 6 6 1.000 0.001 GO:0050896 BP 1 response to stimulus 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.75e-03 6 6 1 0.167 0.167 GO:0004862 MF 1 cAMP-dependent protein kinase inhibitor activity 1 Q9UGJ0 448 4.77e-03 650 6 3 0.500 0.005 GO:0031401 BP 1 positive regulation of protein modification process 1 Q9UGJ0,Q13131,P54619 448 4.88e-03 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 5.23e-03 671 6 3 0.500 0.004 GO:0043085 BP 1 positive regulation of catalytic activity 1 Q9UGJ0,Q13131,P54619 448 5.54e-03 7 6 1 0.167 0.143 GO:0010893 BP 1 positive regulation of steroid biosynthetic process 1 Q13131 448 5.90e-03 700 6 3 0.500 0.004 GO:0001932 BP 1 regulation of protein phosphorylation 1 Q9UGJ0,Q13131,P54619 448 6.14e-03 1565 6 4 0.667 0.003 GO:1901564 BP 1 organonitrogen compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 6.53e-03 200 6 2 0.333 0.010 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 Q13131,P54646 448 6.73e-03 733 6 3 0.500 0.004 GO:0006811 BP 1 ion transport 1 Q9UGJ0,O43741,P54646 448 6.98e-03 207 6 2 0.333 0.010 GO:0010506 BP 1 regulation of autophagy 1 Q13131,P54646 448 7.12e-03 9 6 1 0.167 0.111 GO:1902932 BP 1 positive regulation of alcohol biosynthetic process 1 Q13131 448 7.12e-03 9 6 1 0.167 0.111 GO:0045540 BP 1 regulation of cholesterol biosynthetic process 1 Q13131 448 7.23e-03 1635 6 4 0.667 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 7.38e-03 1644 6 4 0.667 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54619 448 7.77e-03 771 6 3 0.500 0.004 GO:1902580 BP 1 single-organism cellular localization 1 Q9UGJ0,O43741,P54646 448 7.90e-03 10 6 1 0.167 0.100 GO:0006677 BP 1 glycosylceramide metabolic process 1 Q13131 448 8.07e-03 223 6 2 0.333 0.009 GO:0032844 BP 1 regulation of homeostatic process 1 Q13131,P54646 448 8.36e-03 2990 6 5 0.833 0.002 GO:0044267 BP 1 cellular protein metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 8.46e-03 2997 6 5 0.833 0.002 GO:0080090 BP 1 regulation of primary metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 8.65e-03 231 6 2 0.333 0.009 GO:0005524 MF 1 ATP binding 1 Q9UGJ0,P54619 448 8.65e-03 231 6 2 0.333 0.009 GO:1901615 BP 1 organic hydroxy compound metabolic process 1 Q9UGJ0,Q13131 448 8.69e-03 11 6 1 0.167 0.091 GO:2000303 BP 1 regulation of ceramide biosynthetic process 1 Q13131 448 8.69e-03 11 6 1 0.167 0.091 GO:1905038 BP 1 regulation of membrane lipid metabolic process 1 Q13131 448 8.69e-03 11 6 1 0.167 0.091 GO:0090153 BP 1 regulation of sphingolipid biosynthetic process 1 Q13131 448 8.69e-03 11 6 1 0.167 0.091 GO:0050995 BP 1 negative regulation of lipid catabolic process 1 Q13131 448 8.79e-03 3022 6 5 0.833 0.002 GO:0031323 BP 1 regulation of cellular metabolic process 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 8.95e-03 3033 6 5 0.833 0.002 GO:0048518 BP 1 positive regulation of biological process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 9.09e-03 237 6 2 0.333 0.008 GO:0009896 BP 1 positive regulation of catabolic process 1 Q13131,P54646 448 9.32e-03 240 6 2 0.333 0.008 GO:0003682 MF 1 chromatin binding 1 Q13131,P54646 448 9.48e-03 12 6 1 0.167 0.083 GO:0045940 BP 1 positive regulation of steroid metabolic process 1 Q13131 448 9.65e-03 832 6 3 0.500 0.004 GO:0032270 BP 1 positive regulation of cellular protein metabolic process 1 Q9UGJ0,Q13131,P54619 448 1.03e-02 850 6 3 0.500 0.004 GO:0044093 BP 1 positive regulation of molecular function 1 Q9UGJ0,Q13131,P54619 448 1.03e-02 13 6 1 0.167 0.077 GO:0090181 BP 1 regulation of cholesterol metabolic process 1 Q13131 448 1.05e-02 255 6 2 0.333 0.008 GO:0032559 MF 1 adenyl ribonucleotide binding 1 Q9UGJ0,P54619 448 1.11e-02 14 6 1 0.167 0.071 GO:0010800 BP 1 positive regulation of peptidyl-threonine phosphorylation 1 Q9UGJ0 448 1.13e-02 3185 6 5 0.833 0.002 GO:0019538 BP 1 protein metabolic process 1 Q9UGJ0,Q9Y478,Q13131,P54646,P54619 448 1.13e-02 265 6 2 0.333 0.008 GO:0030554 MF 1 adenyl nucleotide binding 1 Q9UGJ0,P54619 448 1.13e-02 880 6 3 0.500 0.003 GO:0051247 BP 1 positive regulation of protein metabolic process 1 Q9UGJ0,Q13131,P54619 448 1.16e-02 324 6 2 0.333 0.006 MI:hsa-miR-100* mi 1 MI:hsa-miR-100* 1 Q9UGJ0,Q13131 448 1.18e-02 15 6 1 0.167 0.067 GO:0006688 BP 1 glycosphingolipid biosynthetic process 1 Q13131 448 1.18e-02 15 6 1 0.167 0.067 GO:0046320 BP 1 regulation of fatty acid oxidation 1 Q9UGJ0 448 1.19e-02 272 6 2 0.333 0.007 GO:0031329 BP 1 regulation of cellular catabolic process 1 Q13131,P54646 448 1.21e-02 331 6 2 0.333 0.006 MI:hsa-miR-16-1* mi 1 MI:hsa-miR-16-1* 1 Q9UGJ0,Q13131 448 1.29e-02 922 6 3 0.500 0.003 GO:0010628 BP 1 positive regulation of gene expression 1 Q9Y478,Q13131,P54619 448 1.34e-02 17 6 1 0.167 0.059 GO:0010332 BP 1 response to gamma radiation 1 Q13131 448 1.36e-02 292 6 2 0.333 0.007 GO:1902532 BP 1 negative regulation of intracellular signal transduction 1 Q13131,P54646 448 1.42e-02 18 6 1 0.167 0.056 GO:1902930 BP 1 regulation of alcohol biosynthetic process 1 Q13131 448 1.43e-02 361 6 2 0.333 0.006 MI:mmu-miR-712 mi 1 MI:mmu-miR-712 1 Q9UGJ0,P54619 448 1.45e-02 134 6 2 0.333 0.015 KEGG:04150 keg 1 mTOR signaling pathway 1 Q13131,P54646 448 1.47e-02 967 6 3 0.500 0.003 GO:0031399 BP 1 regulation of protein modification process 1 Q9UGJ0,Q13131,P54619 448 1.51e-02 1994 6 4 0.667 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 1.56e-02 3415 6 5 0.833 0.001 GO:0032991 CC 1 macromolecular complex 1 Q9UGJ0,O43741,Q13131,P54646,P54619 448 1.58e-02 20 6 1 0.167 0.050 GO:0016572 BP 1 histone phosphorylation 1 P54646 448 1.66e-02 21 6 1 0.167 0.048 GO:0050810 BP 1 regulation of steroid biosynthetic process 1 Q13131 448 1.70e-02 327 6 2 0.333 0.006 GO:0035639 MF 1 purine ribonucleoside triphosphate binding 1 Q9UGJ0,P54619 448 1.73e-02 2068 6 4 0.667 0.002 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 1.73e-02 22 6 1 0.167 0.045 GO:0030291 MF 1 protein serine/threonine kinase inhibitor activity 1 Q9UGJ0 448 1.80e-02 2090 6 4 0.667 0.002 GO:0009889 BP 1 regulation of biosynthetic process 1 Q9UGJ0,O43741,Q13131,P54646 448 1.81e-02 23 6 1 0.167 0.043 GO:0010799 BP 1 regulation of peptidyl-threonine phosphorylation 1 Q9UGJ0 448 1.81e-02 23 6 1 0.167 0.043 GO:0004712 MF 1 protein serine/threonine/tyrosine kinase activity 1 P54646 448 1.81e-02 23 6 1 0.167 0.043 GO:0046324 BP 1 regulation of glucose import 1 Q9UGJ0 448 1.82e-02 339 6 2 0.333 0.006 GO:0019901 MF 1 protein kinase binding 1 Q9UGJ0,P54619 448 1.83e-02 411 6 2 0.333 0.005 MI:hsa-miR-584 mi 1 MI:hsa-miR-584 1 Q13131,P54619 448 1.85e-02 5533 6 6 1.000 0.001 GO:0050794 BP 1 regulation of cellular process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 1.90e-02 347 6 2 0.333 0.006 GO:0050801 BP 1 ion homeostasis 1 Q13131,P54646 448 1.92e-02 349 6 2 0.333 0.006 GO:0032549 MF 1 ribonucleoside binding 1 Q9UGJ0,P54619 448 1.92e-02 349 6 2 0.333 0.006 GO:0032550 MF 1 purine ribonucleoside binding 1 Q9UGJ0,P54619 448 1.93e-02 350 6 2 0.333 0.006 GO:0001883 MF 1 purine nucleoside binding 1 Q9UGJ0,P54619 448 1.96e-02 1071 6 3 0.500 0.003 GO:0050790 BP 1 regulation of catalytic activity 1 Q9UGJ0,Q13131,P54619 448 1.97e-02 353 6 2 0.333 0.006 GO:0001882 MF 1 nucleoside binding 1 Q9UGJ0,P54619 448 1.97e-02 25 6 1 0.167 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 Q13131 448 1.97e-02 25 6 1 0.167 0.040 GO:0050994 BP 1 regulation of lipid catabolic process 1 Q13131 448 2.03e-02 434 6 2 0.333 0.005 MI:mmu-miR-463 mi 1 MI:mmu-miR-463 1 Q9UGJ0,Q13131 448 2.05e-02 5629 6 6 1.000 0.001 GO:0044444 CC 1 cytoplasmic part 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.11e-02 366 6 2 0.333 0.005 GO:0032555 MF 1 purine ribonucleotide binding 1 Q9UGJ0,P54619 448 2.14e-02 2192 6 4 0.667 0.002 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 Q9UGJ0,Q13131,P54646,P54619 448 2.17e-02 372 6 2 0.333 0.005 GO:0032553 MF 1 ribonucleotide binding 1 Q9UGJ0,P54619 448 2.24e-02 378 6 2 0.333 0.005 GO:0017076 MF 1 purine nucleotide binding 1 Q9UGJ0,P54619 448 2.28e-02 29 6 1 0.167 0.034 GO:0046323 BP 1 glucose import 1 Q9UGJ0 448 2.33e-02 386 6 2 0.333 0.005 GO:0019900 MF 1 kinase binding 1 Q9UGJ0,P54619 448 2.36e-02 30 6 1 0.167 0.033 GO:0016239 BP 1 positive regulation of macroautophagy 1 P54646 448 2.42e-02 5787 6 6 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.50e-02 1 6 1 0.167 1.000 HP:0100598 hp 1 Pulmonary edema 1 Q9UGJ0 448 2.50e-02 1 6 1 0.167 1.000 HP:0006684 hp 1 Ventricular preexcitation with multiple accessory pathways 1 Q9UGJ0 448 2.56e-02 5839 6 6 1.000 0.001 GO:0050789 BP 1 regulation of biological process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.56e-02 491 6 2 0.333 0.004 MI:hsa-miR-543 mi 1 MI:hsa-miR-543 1 Q9UGJ0,Q13131 448 2.59e-02 408 6 2 0.333 0.005 GO:0043066 BP 1 negative regulation of apoptotic process 1 Q13131,P54646 448 2.66e-02 5877 6 6 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 2.67e-02 34 6 1 0.167 0.029 GO:0019218 BP 1 regulation of steroid metabolic process 1 Q13131 448 2.67e-02 34 6 1 0.167 0.029 GO:0046513 BP 1 ceramide biosynthetic process 1 Q13131 448 2.67e-02 34 6 1 0.167 0.029 GO:0046889 BP 1 positive regulation of lipid biosynthetic process 1 Q13131 448 2.69e-02 416 6 2 0.333 0.005 GO:0043069 BP 1 negative regulation of programmed cell death 1 Q13131,P54646 448 2.75e-02 35 6 1 0.167 0.029 GO:0006754 BP 1 ATP biosynthetic process 1 Q9UGJ0 448 2.83e-02 36 6 1 0.167 0.028 GO:0030295 MF 1 protein kinase activator activity 1 Q9UGJ0 448 2.90e-02 525 6 2 0.333 0.004 MI:hsa-miR-212 mi 1 MI:hsa-miR-212 1 Q9UGJ0,Q13131 448 2.91e-02 37 6 1 0.167 0.027 GO:0009206 BP 1 purine ribonucleoside triphosphate biosynthetic process 1 Q9UGJ0 448 2.91e-02 37 6 1 0.167 0.027 GO:0009145 BP 1 purine nucleoside triphosphate biosynthetic process 1 Q9UGJ0 448 2.92e-02 1237 6 3 0.500 0.002 GO:0046907 BP 1 intracellular transport 1 Q9UGJ0,O43741,P54646 448 2.99e-02 38 6 1 0.167 0.026 GO:0009201 BP 1 ribonucleoside triphosphate biosynthetic process 1 Q9UGJ0 448 2.99e-02 38 6 1 0.167 0.026 GO:0006695 BP 1 cholesterol biosynthetic process 1 Q13131 448 2.99e-02 38 6 1 0.167 0.026 GO:1902653 BP 1 secondary alcohol biosynthetic process 1 Q13131 448 3.05e-02 539 6 2 0.333 0.004 MI:hsa-let-7g* mi 1 MI:hsa-let-7g* 1 Q9Y478,Q13131 448 3.06e-02 39 6 1 0.167 0.026 GO:0009247 BP 1 glycolipid biosynthetic process 1 Q13131 448 3.10e-02 448 6 2 0.333 0.004 GO:0060548 BP 1 negative regulation of cell death 1 Q13131,P54646 448 3.14e-02 40 6 1 0.167 0.025 GO:0019209 MF 1 kinase activator activity 1 Q9UGJ0 448 3.14e-02 40 6 1 0.167 0.025 GO:0045833 BP 1 negative regulation of lipid metabolic process 1 Q13131 448 3.15e-02 549 6 2 0.333 0.004 MI:hsa-miR-181b mi 1 MI:hsa-miR-181b 1 Q9UGJ0,Q13131 448 3.19e-02 552 6 2 0.333 0.004 MI:hsa-miR-181c mi 1 MI:hsa-miR-181c 1 Q9UGJ0,Q13131 448 3.31e-02 563 6 2 0.333 0.004 MI:hsa-miR-181d mi 1 MI:hsa-miR-181d 1 Q9UGJ0,Q13131 448 3.32e-02 4019 6 5 0.833 0.001 GO:0003824 MF 1 catalytic activity 1 Q9Y478,O43741,Q13131,P54646,P54619 448 3.34e-02 466 6 2 0.333 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q9UGJ0,Q13131 448 3.42e-02 6128 6 6 1.000 0.001 GO:0044238 BP 1 primary metabolic process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.52e-02 479 6 2 0.333 0.004 GO:0000166 MF 1 nucleotide binding 1 Q9UGJ0,P54619 448 3.53e-02 45 6 1 0.167 0.022 GO:0005977 BP 1 glycogen metabolic process 1 Q9UGJ0 448 3.53e-02 45 6 1 0.167 0.022 GO:0006073 BP 1 cellular glucan metabolic process 1 Q9UGJ0 448 3.53e-02 45 6 1 0.167 0.022 GO:0044042 BP 1 glucan metabolic process 1 Q9UGJ0 448 3.53e-02 480 6 2 0.333 0.004 GO:1901265 MF 1 nucleoside phosphate binding 1 Q9UGJ0,P54619 448 3.65e-02 1342 6 3 0.500 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 Q9UGJ0,Q13131,P54619 448 3.74e-02 580 6 2 0.333 0.003 HPA:046010_13 hpa 1 tonsil; germinal center cells[Supportive,High] 1 Q9UGJ0,Q9Y478 448 3.76e-02 48 6 1 0.167 0.021 GO:0006672 BP 1 ceramide metabolic process 1 Q13131 448 3.82e-02 6242 6 6 1.000 0.001 GO:0065007 BP 1 biological regulation 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.91e-02 6266 6 6 1.000 0.001 GO:0044763 BP 1 single-organism cellular process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 3.91e-02 1377 6 3 0.500 0.002 GO:0071702 BP 1 organic substance transport 1 Q9UGJ0,O43741,P54646 448 3.92e-02 50 6 1 0.167 0.020 GO:0009142 BP 1 nucleoside triphosphate biosynthetic process 1 Q9UGJ0 448 3.92e-02 50 6 1 0.167 0.020 GO:0006112 BP 1 energy reserve metabolic process 1 Q9UGJ0 448 3.99e-02 512 6 2 0.333 0.004 GO:0048878 BP 1 chemical homeostasis 1 Q13131,P54646 448 4.00e-02 51 6 1 0.167 0.020 GO:0009168 BP 1 purine ribonucleoside monophosphate biosynthetic process 1 Q9UGJ0 448 4.00e-02 51 6 1 0.167 0.020 GO:0009127 BP 1 purine nucleoside monophosphate biosynthetic process 1 Q9UGJ0 448 4.00e-02 1388 6 3 0.500 0.002 GO:0065009 BP 1 regulation of molecular function 1 Q9UGJ0,Q13131,P54619 448 4.03e-02 6299 6 6 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.07e-02 52 6 1 0.167 0.019 GO:0006687 BP 1 glycosphingolipid metabolic process 1 Q13131 448 4.13e-02 1122 6 4 0.667 0.004 TF:M03985_0 tf 1 Factor: ETV6; motif: NSCGGAAGTR; match class: 0 1 Q9UGJ0,Q9Y478,Q13131,P54619 448 4.15e-02 53 6 1 0.167 0.019 GO:0009156 BP 1 ribonucleoside monophosphate biosynthetic process 1 Q9UGJ0 448 4.18e-02 6336 6 6 1.000 0.001 GO:0005515 MF 1 protein binding 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.31e-02 55 6 1 0.167 0.018 GO:0009124 BP 1 nucleoside monophosphate biosynthetic process 1 Q9UGJ0 448 4.34e-02 2813 6 4 0.667 0.001 HPA:043010_03 hpa 1 stomach 2; glandular cells[Uncertain,High] 1 Q9UGJ0,Q9Y478,O43741,P54646 448 4.37e-02 631 6 2 0.333 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q9UGJ0,Q9Y478 448 4.38e-02 56 6 1 0.167 0.018 GO:0044264 BP 1 cellular polysaccharide metabolic process 1 Q9UGJ0 448 4.41e-02 540 6 2 0.333 0.004 GO:0097367 MF 1 carbohydrate derivative binding 1 Q9UGJ0,P54619 448 4.43e-02 1442 6 3 0.500 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 Q9UGJ0,Q13131,P54619 448 4.54e-02 58 6 1 0.167 0.017 GO:0018107 BP 1 peptidyl-threonine phosphorylation 1 Q9UGJ0 448 4.54e-02 58 6 1 0.167 0.017 GO:0042451 BP 1 purine nucleoside biosynthetic process 1 Q9UGJ0 448 4.54e-02 58 6 1 0.167 0.017 GO:0010827 BP 1 regulation of glucose transport 1 Q9UGJ0 448 4.54e-02 58 6 1 0.167 0.017 GO:0046129 BP 1 purine ribonucleoside biosynthetic process 1 Q9UGJ0 448 4.77e-02 61 6 1 0.167 0.016 GO:0018210 BP 1 peptidyl-threonine modification 1 Q9UGJ0 448 4.77e-02 61 6 1 0.167 0.016 GO:0004860 MF 1 protein kinase inhibitor activity 1 Q9UGJ0 448 4.80e-02 6484 6 6 1.000 0.001 GO:0071704 BP 1 organic substance metabolic process 1 Q9UGJ0,Q9Y478,O43741,Q13131,P54646,P54619 448 4.85e-02 62 6 1 0.167 0.016 GO:0046165 BP 1 alcohol biosynthetic process 1 Q13131 448 4.87e-02 1493 6 3 0.500 0.002 GO:0051649 BP 1 establishment of localization in cell 1 Q9UGJ0,O43741,P54646 448 4.91e-02 2761 6 4 0.667 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 Q9UGJ0,Q13131,P54646,P54619 448 4.91e-02 1498 6 3 0.500 0.002 GO:0044765 BP 1 single-organism transport 1 Q9UGJ0,O43741,P54646 448 4.92e-02 63 6 1 0.167 0.016 GO:0019210 MF 1 kinase inhibitor activity 1 Q9UGJ0 448 5.00e-02 257 6 2 0.333 0.008 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 Q13131,P54646 448 5.00e-02 64 6 1 0.167 0.016 GO:0030148 BP 1 sphingolipid biosynthetic process 1 Q13131 448 5.00e-02 2 6 1 0.167 0.500 HP:0006677 hp 1 Prolonged QRS complex 1 Q9UGJ0 448 5.00e-02 606 6 3 0.500 0.005 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 Q9UGJ0,O43741,P54646 448 5.00e-02 2 6 1 0.167 0.500 TF:M06432_0 tf 1 Factor: ZNF571; motif: NGATWAGGCGGA; match class: 0 1 Q13131 448 5.00e-02 18 6 1 0.167 0.056 OMIM:192600 omi 1 Hypertrophic Cardiomyopathy 1 Q9UGJ0 448 5.00e-02 2 6 1 0.167 0.500 TF:M03984_1 tf 1 Factor: ETV6; motif: CCGGAASCGGAAGTR; match class: 1 1 Q9Y478 448 5.00e-02 2 6 1 0.167 0.500 CORUM:771 cor 1 NDPKA-AMPKalpha1 complex 1 Q13131 448 5.00e-02 2 6 1 0.167 0.500 HP:0200128 hp 1 Biventricular hypertrophy 1 Q9UGJ0 449 5.18e-04 1 2 1 0.500 1.000 GO:2000451 BP 1 positive regulation of CD8-positive, alpha-beta T cell extravasation 1 Q13158 449 5.18e-04 1 2 1 0.500 1.000 GO:2000409 BP 1 positive regulation of T cell extravasation 1 Q13158 449 5.18e-04 1 2 1 0.500 1.000 GO:2000454 BP 1 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation 1 Q13158 449 5.18e-04 1 2 1 0.500 1.000 GO:0089720 MF 1 caspase binding 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:0035697 BP 1 CD8-positive, alpha-beta T cell extravasation 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:0035698 BP 1 CD8-positive, alpha-beta cytotoxic T cell extravasation 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:2000449 BP 1 regulation of CD8-positive, alpha-beta T cell extravasation 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:0072683 BP 1 T cell extravasation 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:0070236 BP 1 negative regulation of activation-induced cell death of T cells 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:2000452 BP 1 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation 1 Q13158 449 1.04e-03 2 2 1 0.500 0.500 GO:0047179 MF 1 platelet-activating factor acetyltransferase activity 1 P68402 449 1.04e-03 2 2 1 0.500 0.500 GO:2000407 BP 1 regulation of T cell extravasation 1 Q13158 449 1.55e-03 3 2 1 0.500 0.333 GO:0035877 MF 1 death effector domain binding 1 Q13158 449 1.55e-03 3 2 1 0.500 0.333 GO:0070235 BP 1 regulation of activation-induced cell death of T cells 1 Q13158 449 1.55e-03 3 2 1 0.500 0.333 GO:0048535 BP 1 lymph node development 1 Q13158 449 1.68e-03 459 2 2 1.000 0.004 MI:hsa-miR-605 mi 1 MI:hsa-miR-605 1 Q13158,P68402 449 1.70e-03 5 2 1 0.500 0.200 REAC:75157 rea 1 FasL/ CD95L signaling 1 Q13158 449 1.70e-03 5 2 1 0.500 0.200 REAC:75158 rea 1 TRAIL signaling 1 Q13158 449 2.07e-03 4 2 1 0.500 0.250 GO:0006924 BP 1 activation-induced cell death of T cells 1 Q13158 449 2.07e-03 4 2 1 0.500 0.250 GO:0045651 BP 1 positive regulation of macrophage differentiation 1 Q13158 449 2.07e-03 4 2 1 0.500 0.250 GO:0002693 BP 1 positive regulation of cellular extravasation 1 Q13158 449 2.59e-03 5 2 1 0.500 0.200 GO:0031265 CC 1 CD95 death-inducing signaling complex 1 Q13158 449 2.59e-03 5 2 1 0.500 0.200 GO:0070233 BP 1 negative regulation of T cell apoptotic process 1 Q13158 449 2.59e-03 5 2 1 0.500 0.200 GO:0060340 BP 1 positive regulation of type I interferon-mediated signaling pathway 1 Q13158 449 3.06e-03 9 2 1 0.500 0.111 REAC:3371378 rea 1 Regulation by c-FLIP 1 Q13158 449 3.06e-03 9 2 1 0.500 0.111 REAC:2562578 rea 1 TRIF-mediated programmed cell death 1 Q13158 449 3.06e-03 9 2 1 0.500 0.111 REAC:69416 rea 1 Dimerization of procaspase-8 1 Q13158 449 3.06e-03 9 2 1 0.500 0.111 REAC:5218900 rea 1 CASP8 activity is inhibited 1 Q13158 449 3.11e-03 6 2 1 0.500 0.167 GO:0097342 CC 1 ripoptosome 1 Q13158 449 3.11e-03 6 2 1 0.500 0.167 GO:0097527 BP 1 necroptotic signaling pathway 1 Q13158 449 3.11e-03 6 2 1 0.500 0.167 GO:0048536 BP 1 spleen development 1 Q13158 449 3.11e-03 6 2 1 0.500 0.167 GO:0001916 BP 1 positive regulation of T cell mediated cytotoxicity 1 Q13158 449 3.11e-03 6 2 1 0.500 0.167 GO:0036462 BP 1 TRAIL-activated apoptotic signaling pathway 1 Q13158 449 3.40e-03 10 2 1 0.500 0.100 REAC:5357786 rea 1 TNFR1-induced proapoptotic signaling 1 Q13158 449 3.62e-03 7 2 1 0.500 0.143 GO:0002691 BP 1 regulation of cellular extravasation 1 Q13158 449 4.08e-03 12 2 1 0.500 0.083 REAC:5675482 rea 1 Regulation of necroptotic cell death 1 Q13158 449 4.08e-03 12 2 1 0.500 0.083 REAC:933543 rea 1 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1 Q13158 449 4.14e-03 8 2 1 0.500 0.125 GO:0045649 BP 1 regulation of macrophage differentiation 1 Q13158 449 4.14e-03 8 2 1 0.500 0.125 GO:0031264 CC 1 death-inducing signaling complex 1 Q13158 449 4.14e-03 8 2 1 0.500 0.125 GO:0005123 MF 1 death receptor binding 1 Q13158 449 4.14e-03 8 2 1 0.500 0.125 GO:0001914 BP 1 regulation of T cell mediated cytotoxicity 1 Q13158 449 4.14e-03 8 2 1 0.500 0.125 GO:0071550 BP 1 death-inducing signaling complex assembly 1 Q13158 449 4.66e-03 9 2 1 0.500 0.111 GO:0097202 BP 1 activation of cysteine-type endopeptidase activity 1 Q13158 449 4.66e-03 9 2 1 0.500 0.111 GO:0043029 BP 1 T cell homeostasis 1 Q13158 449 4.66e-03 9 2 1 0.500 0.111 GO:2000406 BP 1 positive regulation of T cell migration 1 Q13158 449 4.66e-03 9 2 1 0.500 0.111 GO:0097296 BP 1 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1 Q13158 449 4.76e-03 14 2 1 0.500 0.071 REAC:5218859 rea 1 Regulated Necrosis 1 Q13158 449 4.76e-03 14 2 1 0.500 0.071 REAC:5213460 rea 1 RIPK1-mediated regulated necrosis 1 Q13158 449 4.76e-03 14 2 1 0.500 0.071 REAC:140534 rea 1 Ligand-dependent caspase activation 1 Q13158 449 5.17e-03 10 2 1 0.500 0.100 GO:0048538 BP 1 thymus development 1 Q13158 449 5.17e-03 10 2 1 0.500 0.100 GO:0042104 BP 1 positive regulation of activated T cell proliferation 1 Q13158 449 5.17e-03 10 2 1 0.500 0.100 GO:2000403 BP 1 positive regulation of lymphocyte migration 1 Q13158 449 5.69e-03 11 2 1 0.500 0.091 GO:2000404 BP 1 regulation of T cell migration 1 Q13158 449 5.69e-03 11 2 1 0.500 0.091 GO:0001913 BP 1 T cell mediated cytotoxicity 1 Q13158 449 6.21e-03 12 2 1 0.500 0.083 GO:0070229 BP 1 negative regulation of lymphocyte apoptotic process 1 Q13158 449 6.21e-03 12 2 1 0.500 0.083 GO:2001269 BP 1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1 Q13158 449 6.73e-03 13 2 1 0.500 0.077 GO:0030225 BP 1 macrophage differentiation 1 Q13158 449 6.73e-03 13 2 1 0.500 0.077 GO:0002260 BP 1 lymphocyte homeostasis 1 Q13158 449 7.24e-03 14 2 1 0.500 0.071 GO:0070232 BP 1 regulation of T cell apoptotic process 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:2001267 BP 1 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:0001961 BP 1 positive regulation of cytokine-mediated signaling pathway 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:0031343 BP 1 positive regulation of cell killing 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:0001912 BP 1 positive regulation of leukocyte mediated cytotoxicity 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:2000401 BP 1 regulation of lymphocyte migration 1 Q13158 449 7.76e-03 15 2 1 0.500 0.067 GO:0004623 MF 1 phospholipase A2 activity 1 P68402 449 7.82e-03 23 2 1 0.500 0.043 REAC:5357769 rea 1 Caspase activation via extrinsic apoptotic signalig pathway 1 Q13158 449 8.28e-03 16 2 1 0.500 0.062 GO:0072678 BP 1 T cell migration 1 Q13158 449 8.28e-03 16 2 1 0.500 0.062 GO:0046006 BP 1 regulation of activated T cell proliferation 1 Q13158 449 8.28e-03 16 2 1 0.500 0.062 GO:0060760 BP 1 positive regulation of response to cytokine stimulus 1 Q13158 449 8.79e-03 17 2 1 0.500 0.059 GO:2000107 BP 1 negative regulation of leukocyte apoptotic process 1 Q13158 449 9.31e-03 18 2 1 0.500 0.056 GO:0070231 BP 1 T cell apoptotic process 1 Q13158 449 9.31e-03 18 2 1 0.500 0.056 GO:0002711 BP 1 positive regulation of T cell mediated immunity 1 Q13158 449 9.40e-03 3 2 1 0.500 0.333 HP:0003771 hp 1 Pulp stones 1 Q13158 449 9.83e-03 19 2 1 0.500 0.053 GO:0001776 BP 1 leukocyte homeostasis 1 Q13158 449 9.83e-03 19 2 1 0.500 0.053 GO:0050798 BP 1 activated T cell proliferation 1 Q13158 449 9.86e-03 29 2 1 0.500 0.034 REAC:6811436 rea 1 COPI-independent Golgi-to-ER retrograde traffic 1 P68402 449 1.03e-02 20 2 1 0.500 0.050 GO:0033077 BP 1 T cell differentiation in thymus 1 Q13158 449 1.03e-02 20 2 1 0.500 0.050 GO:0071594 BP 1 thymocyte aggregation 1 Q13158 449 1.03e-02 20 2 1 0.500 0.050 GO:0002763 BP 1 positive regulation of myeloid leukocyte differentiation 1 Q13158 449 1.09e-02 21 2 1 0.500 0.048 GO:0032813 MF 1 tumor necrosis factor receptor superfamily binding 1 Q13158 449 1.09e-02 21 2 1 0.500 0.048 GO:0045123 BP 1 cellular extravasation 1 Q13158 449 1.14e-02 22 2 1 0.500 0.045 GO:0035666 BP 1 TRIF-dependent toll-like receptor signaling pathway 1 Q13158 449 1.14e-02 22 2 1 0.500 0.045 GO:2001238 BP 1 positive regulation of extrinsic apoptotic signaling pathway 1 Q13158 449 1.19e-02 23 2 1 0.500 0.043 GO:0070266 BP 1 necroptotic process 1 Q13158 449 1.19e-02 23 2 1 0.500 0.043 GO:0032729 BP 1 positive regulation of interferon-gamma production 1 Q13158 449 1.24e-02 24 2 1 0.500 0.042 GO:0031341 BP 1 regulation of cell killing 1 Q13158 449 1.24e-02 24 2 1 0.500 0.042 GO:0001910 BP 1 regulation of leukocyte mediated cytotoxicity 1 Q13158 449 1.24e-02 24 2 1 0.500 0.042 GO:1902042 BP 1 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 1 Q13158 449 1.24e-02 24 2 1 0.500 0.042 GO:0002709 BP 1 regulation of T cell mediated immunity 1 Q13158 449 1.24e-02 24 2 1 0.500 0.042 GO:0002824 BP 1 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q13158 449 1.25e-02 4 2 1 0.500 0.250 HP:0100719 hp 1 Lens coloboma 1 Q13158 449 1.29e-02 38 2 1 0.500 0.026 REAC:75893 rea 1 TNF signaling 1 Q13158 449 1.29e-02 25 2 1 0.500 0.040 GO:0002756 BP 1 MyD88-independent toll-like receptor signaling pathway 1 Q13158 449 1.29e-02 25 2 1 0.500 0.040 GO:0072676 BP 1 lymphocyte migration 1 Q13158 449 1.29e-02 25 2 1 0.500 0.040 GO:0097300 BP 1 programmed necrotic cell death 1 Q13158 449 1.29e-02 25 2 1 0.500 0.040 GO:0032760 BP 1 positive regulation of tumor necrosis factor production 1 Q13158 449 1.34e-02 26 2 1 0.500 0.038 GO:0070228 BP 1 regulation of lymphocyte apoptotic process 1 Q13158 449 1.34e-02 26 2 1 0.500 0.038 GO:1903557 BP 1 positive regulation of tumor necrosis factor superfamily cytokine production 1 Q13158 449 1.34e-02 26 2 1 0.500 0.038 GO:0031638 BP 1 zymogen activation 1 Q13158 449 1.34e-02 26 2 1 0.500 0.038 GO:0060338 BP 1 regulation of type I interferon-mediated signaling pathway 1 Q13158 449 1.40e-02 27 2 1 0.500 0.037 GO:0032757 BP 1 positive regulation of interleukin-8 production 1 Q13158 449 1.40e-02 27 2 1 0.500 0.037 GO:0002708 BP 1 positive regulation of lymphocyte mediated immunity 1 Q13158 449 1.45e-02 28 2 1 0.500 0.036 GO:0071260 BP 1 cellular response to mechanical stimulus 1 Q13158 449 1.45e-02 28 2 1 0.500 0.036 GO:0002821 BP 1 positive regulation of adaptive immune response 1 Q13158 449 1.46e-02 43 2 1 0.500 0.023 REAC:73887 rea 1 Death Receptor Signalling 1 Q13158 449 1.55e-02 30 2 1 0.500 0.033 GO:0016239 BP 1 positive regulation of macroautophagy 1 P68402 449 1.60e-02 31 2 1 0.500 0.032 GO:0070227 BP 1 lymphocyte apoptotic process 1 Q13158 449 1.71e-02 33 2 1 0.500 0.030 GO:0042102 BP 1 positive regulation of T cell proliferation 1 Q13158 449 1.76e-02 34 2 1 0.500 0.029 GO:0070265 BP 1 necrotic cell death 1 Q13158 449 1.76e-02 34 2 1 0.500 0.029 GO:0032677 BP 1 regulation of interleukin-8 production 1 Q13158 449 1.76e-02 34 2 1 0.500 0.029 GO:1902041 BP 1 regulation of extrinsic apoptotic signaling pathway via death domain receptors 1 Q13158 449 1.76e-02 34 2 1 0.500 0.029 GO:0002456 BP 1 T cell mediated immunity 1 Q13158 449 1.81e-02 35 2 1 0.500 0.029 GO:0032649 BP 1 regulation of interferon-gamma production 1 Q13158 449 1.86e-02 36 2 1 0.500 0.028 GO:2000106 BP 1 regulation of leukocyte apoptotic process 1 Q13158 449 1.86e-02 36 2 1 0.500 0.028 GO:0002705 BP 1 positive regulation of leukocyte mediated immunity 1 Q13158 449 1.96e-02 38 2 1 0.500 0.026 GO:0001909 BP 1 leukocyte mediated cytotoxicity 1 Q13158 449 1.96e-02 38 2 1 0.500 0.026 GO:0045639 BP 1 positive regulation of myeloid cell differentiation 1 Q13158 449 1.96e-02 38 2 1 0.500 0.026 GO:0032637 BP 1 interleukin-8 production 1 Q13158 449 2.02e-02 39 2 1 0.500 0.026 GO:0002687 BP 1 positive regulation of leukocyte migration 1 Q13158 449 2.02e-02 39 2 1 0.500 0.026 GO:0032609 BP 1 interferon-gamma production 1 Q13158 449 2.02e-02 39 2 1 0.500 0.026 GO:0002761 BP 1 regulation of myeloid leukocyte differentiation 1 Q13158 449 2.07e-02 40 2 1 0.500 0.025 GO:0002822 BP 1 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q13158 449 2.07e-02 938 2 2 1.000 0.002 REAC:168249 rea 1 Innate Immune System 1 Q13158,P68402 449 2.10e-02 62 2 1 0.500 0.016 REAC:168928 rea 1 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 1 Q13158 449 2.12e-02 41 2 1 0.500 0.024 GO:0001906 BP 1 cell killing 1 Q13158 449 2.22e-02 43 2 1 0.500 0.023 GO:0071887 BP 1 leukocyte apoptotic process 1 Q13158 449 2.27e-02 44 2 1 0.500 0.023 GO:0050671 BP 1 positive regulation of lymphocyte proliferation 1 Q13158 449 2.27e-02 44 2 1 0.500 0.023 GO:0032946 BP 1 positive regulation of mononuclear cell proliferation 1 Q13158 449 2.27e-02 44 2 1 0.500 0.023 GO:0002706 BP 1 regulation of lymphocyte mediated immunity 1 Q13158 449 2.32e-02 45 2 1 0.500 0.022 GO:0070665 BP 1 positive regulation of leukocyte proliferation 1 Q13158 449 2.32e-02 45 2 1 0.500 0.022 GO:0032680 BP 1 regulation of tumor necrosis factor production 1 Q13158 449 2.38e-02 46 2 1 0.500 0.022 GO:0032640 BP 1 tumor necrosis factor production 1 Q13158 449 2.38e-02 46 2 1 0.500 0.022 GO:0002819 BP 1 regulation of adaptive immune response 1 Q13158 449 2.43e-02 47 2 1 0.500 0.021 GO:1903555 BP 1 regulation of tumor necrosis factor superfamily cytokine production 1 Q13158 449 2.43e-02 47 2 1 0.500 0.021 GO:0042129 BP 1 regulation of T cell proliferation 1 Q13158 449 2.50e-02 8 2 1 0.500 0.125 HP:0004935 hp 1 Pulmonary artery atresia 1 Q13158 449 2.53e-02 49 2 1 0.500 0.020 GO:0060337 BP 1 type I interferon signaling pathway 1 Q13158 449 2.53e-02 49 2 1 0.500 0.020 GO:0071357 BP 1 cellular response to type I interferon 1 Q13158 449 2.53e-02 49 2 1 0.500 0.020 GO:0071706 BP 1 tumor necrosis factor superfamily cytokine production 1 Q13158 449 2.63e-02 51 2 1 0.500 0.020 GO:1902107 BP 1 positive regulation of leukocyte differentiation 1 Q13158 449 2.69e-02 52 2 1 0.500 0.019 GO:0034340 BP 1 response to type I interferon 1 Q13158 449 2.74e-02 53 2 1 0.500 0.019 GO:0009612 BP 1 response to mechanical stimulus 1 Q13158 449 2.78e-02 1113 2 2 1.000 0.002 GO:0048513 BP 1 animal organ development 1 Q13158,P68402 449 2.79e-02 54 2 1 0.500 0.019 GO:0042098 BP 1 T cell proliferation 1 Q13158 449 2.79e-02 54 2 1 0.500 0.019 GO:0006919 BP 1 activation of cysteine-type endopeptidase activity involved in apoptotic process 1 Q13158 449 2.84e-02 55 2 1 0.500 0.018 GO:0008625 BP 1 extrinsic apoptotic signaling pathway via death domain receptors 1 Q13158 449 2.89e-02 56 2 1 0.500 0.018 GO:0002685 BP 1 regulation of leukocyte migration 1 Q13158 449 2.98e-02 88 2 1 0.500 0.011 REAC:168164 rea 1 Toll Like Receptor 3 (TLR3) Cascade 1 Q13158 449 2.98e-02 88 2 1 0.500 0.011 REAC:937061 rea 1 TRIF-mediated TLR3/TLR4 signaling 1 Q13158 449 2.98e-02 88 2 1 0.500 0.011 REAC:166166 rea 1 MyD88-independent TLR3/TLR4 cascade 1 Q13158 449 2.99e-02 58 2 1 0.500 0.017 GO:0004620 MF 1 phospholipase activity 1 P68402 449 3.10e-02 60 2 1 0.500 0.017 GO:0010508 BP 1 positive regulation of autophagy 1 P68402 449 3.10e-02 60 2 1 0.500 0.017 GO:2001237 BP 1 negative regulation of extrinsic apoptotic signaling pathway 1 Q13158 449 3.20e-02 62 2 1 0.500 0.016 GO:0032944 BP 1 regulation of mononuclear cell proliferation 1 Q13158 449 3.20e-02 62 2 1 0.500 0.016 GO:0050670 BP 1 regulation of lymphocyte proliferation 1 Q13158 449 3.30e-02 64 2 1 0.500 0.016 GO:0070663 BP 1 regulation of leukocyte proliferation 1 Q13158 449 3.36e-02 65 2 1 0.500 0.015 GO:0002703 BP 1 regulation of leukocyte mediated immunity 1 Q13158 449 3.36e-02 65 2 1 0.500 0.015 GO:0052689 MF 1 carboxylic ester hydrolase activity 1 P68402 449 3.38e-02 100 2 1 0.500 0.010 REAC:166054 rea 1 Activated TLR4 signalling 1 Q13158 449 3.41e-02 66 2 1 0.500 0.015 GO:0048872 BP 1 homeostasis of number of cells 1 Q13158 449 3.41e-02 66 2 1 0.500 0.015 GO:0002699 BP 1 positive regulation of immune effector process 1 Q13158 449 3.41e-02 66 2 1 0.500 0.015 GO:0030217 BP 1 T cell differentiation 1 Q13158 449 3.56e-02 69 2 1 0.500 0.014 GO:0002573 BP 1 myeloid leukocyte differentiation 1 Q13158 449 3.62e-02 107 2 1 0.500 0.009 REAC:8856688 rea 1 Golgi-to-ER retrograde transport 1 P68402 449 3.65e-02 108 2 1 0.500 0.009 REAC:166016 rea 1 Toll Like Receptor 4 (TLR4) Cascade 1 Q13158 449 3.66e-02 71 2 1 0.500 0.014 GO:1903708 BP 1 positive regulation of hemopoiesis 1 Q13158 449 3.72e-02 72 2 1 0.500 0.014 GO:0016298 MF 1 lipase activity 1 P68402 449 3.72e-02 72 2 1 0.500 0.014 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5798 cor 1 Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5541 cor 1 Ternary complex (TRAF2, FADD, TRADD) 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5856 cor 1 AK2-FADD-caspase-10 (AFAC10) complex 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5473 cor 1 FAS-FADD-CASP8 complex 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5800 cor 1 Death-inducing signaling complex DISC (type I cells associated), stimulated 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5861 cor 1 FAS-FADD-CASP10 complex 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5860 cor 1 FAS-FADD-CASP8 complex 1 Q13158 449 3.75e-02 3 2 1 0.500 0.333 CORUM:5991 cor 1 LRRK2-FADD-CASP8 1 Q13158 449 3.82e-02 74 2 1 0.500 0.014 GO:0045637 BP 1 regulation of myeloid cell differentiation 1 Q13158 449 3.87e-02 75 2 1 0.500 0.013 GO:0043280 BP 1 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1 Q13158 449 3.97e-02 77 2 1 0.500 0.013 GO:0002020 MF 1 protease binding 1 Q13158 449 3.97e-02 77 2 1 0.500 0.013 GO:0002449 BP 1 lymphocyte mediated immunity 1 Q13158 449 4.13e-02 80 2 1 0.500 0.013 GO:0046651 BP 1 lymphocyte proliferation 1 Q13158 449 4.13e-02 80 2 1 0.500 0.013 GO:0032943 BP 1 mononuclear cell proliferation 1 Q13158 449 4.23e-02 82 2 1 0.500 0.012 GO:0016407 MF 1 acetyltransferase activity 1 P68402 449 4.28e-02 83 2 1 0.500 0.012 GO:2001236 BP 1 regulation of extrinsic apoptotic signaling pathway 1 Q13158 449 4.28e-02 83 2 1 0.500 0.012 GO:0002224 BP 1 toll-like receptor signaling pathway 1 Q13158 449 4.28e-02 83 2 1 0.500 0.012 GO:2001056 BP 1 positive regulation of cysteine-type endopeptidase activity 1 Q13158 449 4.29e-02 127 2 1 0.500 0.008 REAC:168898 rea 1 Toll-Like Receptors Cascades 1 Q13158 449 4.33e-02 84 2 1 0.500 0.012 GO:1902105 BP 1 regulation of leukocyte differentiation 1 Q13158 449 4.33e-02 84 2 1 0.500 0.012 GO:0070661 BP 1 leukocyte proliferation 1 Q13158 449 4.33e-02 84 2 1 0.500 0.012 GO:0048732 BP 1 gland development 1 Q13158 449 4.54e-02 88 2 1 0.500 0.011 GO:0001959 BP 1 regulation of cytokine-mediated signaling pathway 1 Q13158 449 4.59e-02 89 2 1 0.500 0.011 GO:0032845 BP 1 negative regulation of homeostatic process 1 Q13158 449 4.64e-02 90 2 1 0.500 0.011 GO:0010950 BP 1 positive regulation of endopeptidase activity 1 Q13158 449 4.79e-02 93 2 1 0.500 0.011 GO:0050870 BP 1 positive regulation of T cell activation 1 Q13158 449 4.85e-02 94 2 1 0.500 0.011 GO:0060759 BP 1 regulation of response to cytokine stimulus 1 Q13158 449 4.85e-02 94 2 1 0.500 0.011 GO:0010952 BP 1 positive regulation of peptidase activity 1 Q13158 449 4.89e-02 277 2 1 0.500 0.004 MI:hsa-miR-541* mi 1 MI:hsa-miR-541* 1 P68402 449 4.90e-02 95 2 1 0.500 0.011 GO:1903039 BP 1 positive regulation of leukocyte cell-cell adhesion 1 Q13158 449 4.90e-02 95 2 1 0.500 0.011 GO:0002250 BP 1 adaptive immune response 1 Q13158 449 5.00e-02 97 2 1 0.500 0.010 GO:2001235 BP 1 positive regulation of apoptotic signaling pathway 1 Q13158 449 5.00e-02 307 2 2 1.000 0.007 TF:M01816_1 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 1 Q13158,P68402 449 5.00e-02 1 2 1 0.500 1.000 OMIM:613759 omi 1 INFECTIONS, RECURRENT, WITH ENCEPHALOPATHY, HEPATIC DYSFUNCTION, ANDCARDIOVASCULAR MALFORMATIONS;;FADD DEFICIENCY 1 Q13158 449 5.00e-02 29 2 1 0.500 0.034 KEGG:00565 keg 1 Ether lipid metabolism 1 P68402 449 5.00e-02 4 2 1 0.500 0.250 CORUM:2054 cor 1 CASP8-FADD-MALT1-BCL10 complex 1 Q13158 449 5.00e-02 16 2 1 0.500 0.062 HP:0001100 hp 1 Heterochromia iridis 1 Q13158 449 5.00e-02 4 2 1 0.500 0.250 CORUM:5859 cor 1 FAS-FADD-CASP8-CASP10 complex 1 Q13158 449 5.00e-02 4 2 1 0.500 0.250 CORUM:5799 cor 1 Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced 1 Q13158 449 5.00e-02 1457 2 2 1.000 0.001 REAC:168256 rea 1 Immune System 1 Q13158,P68402 450 3.70e-05 133 3 3 1.000 0.023 TF:M06033_0 tf 1 Factor: ZNF878; motif: NGGTTTTANTCM; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 3.78e-05 134 3 3 1.000 0.022 TF:M04480_0 tf 1 Factor: NR4A2; motif: TTTAAAGGTCA; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 8.92e-05 178 3 3 1.000 0.017 TF:M03839_1 tf 1 Factor: Pax-2; motif: CAYSCCTSAGT; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 2.25e-04 242 3 3 1.000 0.012 TF:M00079_0 tf 1 Factor: Evi-1; motif: AGAYAAGATAA; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 4.31e-04 27 3 2 0.667 0.074 TF:M05686_0 tf 1 Factor: ZNF141; motif: NGGGAAAMCTTC; match class: 0 1 Q5VWM5,O60810 450 5.17e-04 319 3 3 1.000 0.009 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 7.38e-04 359 3 3 1.000 0.008 TF:M04421_1 tf 1 Factor: OTX2; motif: NTAATCCN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 1.08e-03 408 3 3 1.000 0.007 TF:M02002_0 tf 1 Factor: Evi-1; motif: TATCTTGTC; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 1.45e-03 449 3 3 1.000 0.007 TF:M03866_1 tf 1 Factor: c-Fos:c-Jun; motif: NTGACTCAN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 4.46e-03 653 3 3 1.000 0.005 TF:M00173_1 tf 1 Factor: AP-1; motif: RSTGACTNANW; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 4.54e-03 657 3 3 1.000 0.005 TF:M07430_1 tf 1 Factor: SNA; motif: NCACCTGCNN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 5.13e-03 684 3 3 1.000 0.004 TF:M00011_0 tf 1 Factor: Evi-1; motif: ACAAGATAA; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 6.71e-03 219 3 2 0.667 0.009 MI:hsa-miR-629* mi 1 MI:hsa-miR-629* 1 Q5VWM5,O60810 450 7.99e-03 793 3 3 1.000 0.004 TF:M00072_1 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 9.50e-03 840 3 3 1.000 0.004 TF:M00172_1 tf 1 Factor: AP-1; motif: RSTGACTNMNW; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 1.22e-02 912 3 3 1.000 0.003 TF:M07392_0 tf 1 Factor: Pitx3; motif: GGATTANNNNY; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 1.23e-02 916 3 3 1.000 0.003 TF:M03889_1 tf 1 Factor: TBX2; motif: AGGTGTGARM; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 1.23e-02 916 3 3 1.000 0.003 TF:M00790_1 tf 1 Factor: HNF1; motif: WRGTTAATNATTAACNNN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 1.30e-02 306 3 2 0.667 0.007 MI:hsa-miR-223* mi 1 MI:hsa-miR-223* 1 Q5VWM5,O60810 450 1.35e-02 944 3 3 1.000 0.003 TF:M00188_1 tf 1 Factor: AP-1; motif: RGTGACTMANN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 1.46e-02 324 3 2 0.667 0.006 MI:hsa-miR-100* mi 1 MI:hsa-miR-100* 1 Q5VWM5,O60810 450 1.55e-02 334 3 2 0.667 0.006 MI:hsa-miR-517* mi 1 MI:hsa-miR-517* 1 Q5VWM5,O60810 450 1.56e-02 335 3 2 0.667 0.006 MI:hsa-miR-376a* mi 1 MI:hsa-miR-376a* 1 Q5VWM5,O60810 450 1.57e-02 993 3 3 1.000 0.003 TF:M00001_0 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 0 1 Q5VWM5,O60810,Q5TYX0 450 1.60e-02 339 3 2 0.667 0.006 MI:hsa-miR-27b* mi 1 MI:hsa-miR-27b* 1 Q5VWM5,O60810 450 1.68e-02 348 3 2 0.667 0.006 MI:hsa-miR-518f* mi 1 MI:hsa-miR-518f* 1 Q5VWM5,O60810 450 1.71e-02 351 3 2 0.667 0.006 MI:hsa-miR-124* mi 1 MI:hsa-miR-124* 1 Q5VWM5,O60810 450 1.72e-02 352 3 2 0.667 0.006 MI:hsa-miR-127-3p mi 1 MI:hsa-miR-127-3p 1 Q5VWM5,O60810 450 1.72e-02 352 3 2 0.667 0.006 MI:hsa-miR-125b-2* mi 1 MI:hsa-miR-125b-2* 1 Q5VWM5,O60810 450 1.79e-02 359 3 2 0.667 0.006 MI:hsa-miR-150 mi 1 MI:hsa-miR-150 1 Q5VWM5,O60810 450 1.85e-02 365 3 2 0.667 0.005 MI:hsa-miR-518e* mi 1 MI:hsa-miR-518e* 1 Q5VWM5,O60810 450 1.95e-02 375 3 2 0.667 0.005 MI:hsa-miR-361-3p mi 1 MI:hsa-miR-361-3p 1 Q5VWM5,O60810 450 1.99e-02 379 3 2 0.667 0.005 MI:mmu-miR-343 mi 1 MI:mmu-miR-343 1 Q5VWM5,O60810 450 2.00e-02 380 3 2 0.667 0.005 MI:hsa-miR-204 mi 1 MI:hsa-miR-204 1 Q5VWM5,O60810 450 2.08e-02 1091 3 3 1.000 0.003 TF:M00302_1 tf 1 Factor: NF-AT; motif: NANWGGAAAANN; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 2.19e-02 397 3 2 0.667 0.005 MI:mmu-miR-684 mi 1 MI:mmu-miR-684 1 Q5VWM5,O60810 450 2.22e-02 400 3 2 0.667 0.005 MI:hsa-miR-10b* mi 1 MI:hsa-miR-10b* 1 Q5VWM5,O60810 450 2.25e-02 403 3 2 0.667 0.005 MI:hsa-miR-181c* mi 1 MI:hsa-miR-181c* 1 Q5VWM5,O60810 450 2.28e-02 406 3 2 0.667 0.005 MI:hsa-miR-573 mi 1 MI:hsa-miR-573 1 Q5VWM5,O60810 450 2.34e-02 411 3 2 0.667 0.005 MI:hsa-miR-181a* mi 1 MI:hsa-miR-181a* 1 Q5VWM5,O60810 450 2.39e-02 415 3 2 0.667 0.005 MI:hsa-miR-455-5p mi 1 MI:hsa-miR-455-5p 1 Q5VWM5,O60810 450 2.41e-02 417 3 2 0.667 0.005 MI:hsa-miR-660 mi 1 MI:hsa-miR-660 1 Q5VWM5,O60810 450 2.41e-02 417 3 2 0.667 0.005 MI:hsa-miR-205 mi 1 MI:hsa-miR-205 1 Q5VWM5,O60810 450 2.42e-02 418 3 2 0.667 0.005 MI:hsa-miR-563 mi 1 MI:hsa-miR-563 1 Q5VWM5,O60810 450 2.44e-02 420 3 2 0.667 0.005 MI:hsa-miR-651 mi 1 MI:hsa-miR-651 1 Q5VWM5,O60810 450 2.49e-02 424 3 2 0.667 0.005 MI:mmu-miR-715 mi 1 MI:mmu-miR-715 1 Q5VWM5,O60810 450 2.50e-02 425 3 2 0.667 0.005 MI:hsa-miR-615-3p mi 1 MI:hsa-miR-615-3p 1 Q5VWM5,O60810 450 2.52e-02 427 3 2 0.667 0.005 MI:hsa-miR-630 mi 1 MI:hsa-miR-630 1 Q5VWM5,O60810 450 2.58e-02 1171 3 3 1.000 0.003 TF:M07057_1 tf 1 Factor: Pitx3; motif: GATTANA; match class: 1 1 Q5VWM5,O60810,Q5TYX0 450 2.64e-02 437 3 2 0.667 0.005 MI:hsa-miR-147 mi 1 MI:hsa-miR-147 1 Q5VWM5,O60810 450 2.74e-02 445 3 2 0.667 0.004 MI:hsa-miR-871 mi 1 MI:hsa-miR-871 1 Q5VWM5,O60810 450 2.84e-02 453 3 2 0.667 0.004 MI:hsa-miR-300 mi 1 MI:hsa-miR-300 1 Q5VWM5,O60810 450 2.85e-02 454 3 2 0.667 0.004 MI:hsa-miR-516a-3p mi 1 MI:hsa-miR-516a-3p 1 Q5VWM5,O60810 450 2.86e-02 455 3 2 0.667 0.004 MI:hsa-miR-198 mi 1 MI:hsa-miR-198 1 Q5VWM5,O60810 450 2.91e-02 459 3 2 0.667 0.004 MI:hsa-miR-21 mi 1 MI:hsa-miR-21 1 Q5VWM5,O60810 450 3.08e-02 472 3 2 0.667 0.004 MI:hsa-miR-525-5p mi 1 MI:hsa-miR-525-5p 1 Q5VWM5,O60810 450 3.14e-02 477 3 2 0.667 0.004 MI:hsa-miR-498 mi 1 MI:hsa-miR-498 1 Q5VWM5,O60810 450 3.17e-02 479 3 2 0.667 0.004 MI:hsa-miR-516a-5p mi 1 MI:hsa-miR-516a-5p 1 Q5VWM5,O60810 450 3.21e-02 482 3 2 0.667 0.004 MI:hsa-miR-491-3p mi 1 MI:hsa-miR-491-3p 1 Q5VWM5,O60810 450 3.26e-02 486 3 2 0.667 0.004 MI:hsa-miR-362-3p mi 1 MI:hsa-miR-362-3p 1 Q5VWM5,O60810 450 3.37e-02 494 3 2 0.667 0.004 MI:hsa-miR-139-5p mi 1 MI:hsa-miR-139-5p 1 Q5VWM5,O60810 450 3.43e-02 499 3 2 0.667 0.004 MI:hsa-miR-499-5p mi 1 MI:hsa-miR-499-5p 1 Q5VWM5,O60810 450 3.49e-02 503 3 2 0.667 0.004 MI:mmu-miR-693-3p mi 1 MI:mmu-miR-693-3p 1 Q5VWM5,O60810 450 4.04e-02 542 3 2 0.667 0.004 MI:hsa-miR-518d-5p mi 1 MI:hsa-miR-518d-5p 1 Q5VWM5,O60810 450 4.07e-02 544 3 2 0.667 0.004 MI:hsa-miR-590-5p mi 1 MI:hsa-miR-590-5p 1 Q5VWM5,O60810 450 4.14e-02 549 3 2 0.667 0.004 MI:hsa-miR-181b mi 1 MI:hsa-miR-181b 1 Q5VWM5,O60810 450 4.19e-02 552 3 2 0.667 0.004 MI:hsa-miR-181c mi 1 MI:hsa-miR-181c 1 Q5VWM5,O60810 450 4.35e-02 563 3 2 0.667 0.004 MI:hsa-miR-520a-5p mi 1 MI:hsa-miR-520a-5p 1 Q5VWM5,O60810 450 5.00e-02 288 3 2 0.667 0.007 TF:M01209_1 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 1 1 Q5VWM5,O60810 450 5.00e-02 604 3 2 0.667 0.003 MI:hsa-miR-520f mi 1 MI:hsa-miR-520f 1 Q5VWM5,O60810 450 5.00e-02 604 3 2 0.667 0.003 MI:mmu-miR-466a-5p mi 1 MI:mmu-miR-466a-5p 1 Q5VWM5,O60810 451 1.21e-04 8 4 2 0.500 0.250 GO:0042288 MF 1 MHC class I protein binding 1 Q9UKJ1,Q9UKJ0 451 2.86e-04 12 4 2 0.500 0.167 GO:0042287 MF 1 MHC protein binding 1 Q9UKJ1,Q9UKJ0 451 2.58e-03 268 4 2 0.500 0.007 TF:M01288_1 tf 1 Factor: NeuroD; motif: NNSCWGCTGNSY; match class: 1 1 Q9UKJ0,Q76KP1 451 3.64e-03 1267 4 3 0.750 0.002 TF:M07242_0 tf 1 Factor: AML1; motif: NNACCACAN; match class: 0 1 Q9UKJ1,Q9UKJ0,Q76KP1 451 3.77e-03 325 4 2 0.500 0.006 TF:M07422_0 tf 1 Factor: MASH-1; motif: CCWBMCACCTGCC; match class: 0 1 Q9UKJ0,Q76KP1 451 6.58e-03 21 4 1 0.250 0.048 TF:M06547_0 tf 1 Factor: ZNF675; motif: NGGTGGGGCAGM; match class: 0 1 Q76KP1 451 6.58e-03 21 4 1 0.250 0.048 TF:M07205_1 tf 1 Factor: CEBPA; motif: ATTGCAYAAYN; match class: 1 1 Q86VH4 451 7.61e-03 3760 4 4 1.000 0.001 TF:M00075_1 tf 1 Factor: GATA-1; motif: SNNGATNNNN; match class: 1 1 Q9UKJ1,Q9UKJ0,Q86VH4,Q76KP1 451 8.23e-03 484 4 2 0.500 0.004 TF:M00418_0 tf 1 Factor: TGIF; motif: AGCTGTCANNA; match class: 0 1 Q9UKJ0,Q86VH4 451 9.71e-03 31 4 1 0.250 0.032 TF:M06910_0 tf 1 Factor: ZNF224; motif: ARAGTSAGTCC; match class: 0 1 Q9UKJ0 451 1.23e-02 595 4 2 0.500 0.003 TF:M00483_1 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 1 1 Q9UKJ1,Q76KP1 451 1.53e-02 49 4 1 0.250 0.020 TF:M00210_1 tf 1 Factor: OCT-x; motif: CTNATTTGCATAY; match class: 1 1 Q86VH4 451 1.66e-02 53 4 1 0.250 0.019 TF:M06549_0 tf 1 Factor: ZNF721; motif: NGARGTGGGGTG; match class: 0 1 Q76KP1 451 1.70e-02 703 4 2 0.500 0.003 TF:M00176_1 tf 1 Factor: AP-4; motif: CWCAGCTGGN; match class: 1 1 Q9UKJ1,Q76KP1 451 1.80e-02 4666 4 4 1.000 0.001 TF:M00794_1 tf 1 Factor: TTF-1; motif: NNNNCAAGNRNN; match class: 1 1 Q9UKJ1,Q9UKJ0,Q86VH4,Q76KP1 451 1.84e-02 59 4 1 0.250 0.017 TF:M04291_1 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 1 1 Q9UKJ0 451 1.87e-02 60 4 1 0.250 0.017 TF:M04123_0 tf 1 Factor: TBX19; motif: NTTMRCACNTANGTGTGAAN; match class: 0 1 Q9UKJ0 451 1.93e-02 62 4 1 0.250 0.016 TF:M06179_0 tf 1 Factor: ZNF445; motif: NGGATAAAGGA; match class: 0 1 Q9UKJ0 451 2.22e-02 808 4 2 0.500 0.002 TF:M00915_1 tf 1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 1 Q9UKJ0,Q76KP1 451 2.48e-02 857 4 2 0.500 0.002 TF:M00698_1 tf 1 Factor: HEB; motif: RCCWGCTG; match class: 1 1 Q9UKJ1,Q76KP1 451 2.49e-02 5056 4 4 1.000 0.001 TF:M02077_1 tf 1 Factor: Spic; motif: NGNGGAASTN; match class: 1 1 Q9UKJ1,Q9UKJ0,Q86VH4,Q76KP1 451 2.49e-02 80 4 1 0.250 0.013 TF:M01125_1 tf 1 Factor: Oct-4; motif: YWTTSTNATGCAAAT; match class: 1 1 Q86VH4 451 2.58e-02 83 4 1 0.250 0.012 TF:M05381_1 tf 1 Factor: ZNF826; motif: GKGCWGCAGM; match class: 1 1 Q76KP1 451 2.58e-02 83 4 1 0.250 0.012 TF:M06720_0 tf 1 Factor: ZNF430; motif: NTGGAGGGCAGA; match class: 0 1 Q9UKJ1 451 2.77e-02 908 4 2 0.500 0.002 TF:M03844_1 tf 1 Factor: SAP-1a; motif: CWTCCKGT; match class: 1 1 Q9UKJ1,Q76KP1 451 2.77e-02 908 4 2 0.500 0.002 TF:M07282_1 tf 1 Factor: ER71; motif: CWTCCTGT; match class: 1 1 Q9UKJ1,Q76KP1 451 2.86e-02 5233 4 4 1.000 0.001 TF:M07379_0 tf 1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 0 1 Q9UKJ1,Q9UKJ0,Q86VH4,Q76KP1 451 3.02e-02 2641 4 3 0.750 0.001 TF:M00947_0 tf 1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 0 1 Q9UKJ0,Q86VH4,Q76KP1 451 3.19e-02 978 4 2 0.500 0.002 TF:M01239_0 tf 1 Factor: RelB:p52; motif: GGGGNTTTCC; match class: 0 1 Q9UKJ0,Q86VH4 451 3.27e-02 5412 4 4 1.000 0.001 TF:M03796_0 tf 1 Factor: MafA; motif: GGTCAGCAGH; match class: 0 1 Q9UKJ1,Q9UKJ0,Q86VH4,Q76KP1 451 3.32e-02 999 4 2 0.500 0.002 TF:M00772_0 tf 1 Factor: IRF; motif: BNCRSTTTCANTTYY; match class: 0 1 Q9UKJ1,Q86VH4 451 3.34e-02 2740 4 3 0.750 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q9UKJ1,Q9UKJ0,Q86VH4 451 3.47e-02 112 4 1 0.250 0.009 TF:M00327_1 tf 1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 1 Q76KP1 451 3.67e-02 1054 4 2 0.500 0.002 TF:M00769_0 tf 1 Factor: AML; motif: NNGKNTGTGGTTWNC; match class: 0 1 Q9UKJ1,Q76KP1 451 3.69e-02 119 4 1 0.250 0.008 TF:M02024_1 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 1 1 Q86VH4 451 3.83e-02 1078 4 2 0.500 0.002 TF:M00414_1 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 1 1 Q9UKJ1,Q76KP1 451 3.90e-02 126 4 1 0.250 0.008 TF:M01303_1 tf 1 Factor: SP1; motif: GGGGYGGGGNS; match class: 1 1 Q76KP1 451 3.98e-02 2917 4 3 0.750 0.001 TF:M02078_1 tf 1 Factor: SPI1; motif: NGRGGAAGTN; match class: 1 1 Q9UKJ1,Q9UKJ0,Q86VH4 451 4.02e-02 130 4 1 0.250 0.008 TF:M00285_1 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 1 1 Q9UKJ0 451 4.05e-02 1110 4 2 0.500 0.002 TF:M00916_1 tf 1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 1 1 Q9UKJ1,Q76KP1 451 4.13e-02 2954 4 3 0.750 0.001 TF:M01861_0 tf 1 Factor: ATF-1; motif: TNACGTCAN; match class: 0 1 Q9UKJ1,Q86VH4,Q76KP1 451 4.87e-02 158 4 1 0.250 0.006 TF:M06398_0 tf 1 Factor: ZNF761; motif: GGKWAATCAGA; match class: 0 1 Q9UKJ1 451 4.93e-02 160 4 1 0.250 0.006 TF:M06001_0 tf 1 Factor: ZNF316; motif: RTTGAAAAGM; match class: 0 1 Q86VH4 451 5.00e-02 3 4 1 0.250 0.333 GO:0007171 BP 1 activation of transmembrane receptor protein tyrosine kinase activity 1 Q9UKJ0 451 5.00e-02 414 4 2 0.500 0.005 MI:hsa-miR-631 mi 1 MI:hsa-miR-631 1 Q9UKJ1,Q76KP1 452 2.86e-03 350 3 2 0.667 0.006 MI:hsa-miR-26a-1* mi 1 MI:hsa-miR-26a-1* 1 Q8TDN4,O43427 452 3.56e-03 117 3 2 0.667 0.017 REAC:983231 rea 1 Factors involved in megakaryocyte development and platelet production 1 Q8TDN4,Q9BTV7 452 4.77e-03 453 3 2 0.667 0.004 MI:hsa-miR-521 mi 1 MI:hsa-miR-521 1 Q8TDN4,Q9BTV7 452 5.48e-03 486 3 2 0.667 0.004 MI:hsa-miR-362-3p mi 1 MI:hsa-miR-362-3p 1 Q8TDN4,O43427 452 6.00e-03 509 3 2 0.667 0.004 MI:mmu-miR-883a-5p mi 1 MI:mmu-miR-883a-5p 1 Q8TDN4,O43427 452 1.17e-02 206 3 2 0.667 0.010 TF:M04257_0 tf 1 Factor: FOXO1; motif: TTTCCCCACACG; match class: 0 1 Q8TDN4,O43427 452 1.24e-02 17 3 1 0.333 0.059 GO:0017134 MF 1 fibroblast growth factor binding 1 O43427 452 3.05e-02 42 3 1 0.333 0.024 GO:0070527 BP 1 platelet aggregation 1 O43427 452 3.92e-02 54 3 1 0.333 0.019 GO:0034109 BP 1 homotypic cell-cell adhesion 1 O43427 452 4.54e-02 407 3 2 0.667 0.005 TF:M03834_1 tf 1 Factor: N-Myc; motif: GSSCACGYGS; match class: 1 1 Q8TDN4,Q9BTV7 452 4.74e-02 416 3 2 0.667 0.005 TF:M00222_1 tf 1 Factor: Hand1:E47; motif: NNNNGNRTCTGGMWTT; match class: 1 1 Q9BTV7,O43427 452 5.00e-02 444 3 2 0.667 0.005 REAC:109582 rea 1 Hemostasis 1 Q8TDN4,Q9BTV7 452 5.00e-02 14 3 1 0.333 0.071 TF:M06378_0 tf 1 Factor: ZNF562; motif: NKGGTCATAAGC; match class: 0 1 O43427 452 5.00e-02 69 3 1 0.333 0.014 GO:0008543 BP 1 fibroblast growth factor receptor signaling pathway 1 O43427 452 5.00e-02 14 3 1 0.333 0.071 TF:M02094_1 tf 1 Factor: ERR3; motif: NNTCAAGGTCACN; match class: 1 1 Q9BTV7 453 2.97e-03 1 4 1 0.250 1.000 OMIM:604286 omi 1 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2E; LGMD2E 1 Q16585 453 2.97e-03 1 4 1 0.250 1.000 OMIM:615802 omi 1 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 42; MRT42 1 Q75T13 453 5.01e-03 1 4 1 0.250 1.000 GO:0015798 BP 1 myo-inositol transport 1 Q75T13 453 1.00e-02 2 4 1 0.250 0.500 GO:0033087 BP 1 negative regulation of immature T cell proliferation 1 A2VDJ0 453 1.00e-02 2 4 1 0.250 0.500 GO:0033083 BP 1 regulation of immature T cell proliferation 1 A2VDJ0 453 1.00e-02 2 4 1 0.250 0.500 GO:0033088 BP 1 negative regulation of immature T cell proliferation in thymus 1 A2VDJ0 453 1.00e-02 2 4 1 0.250 0.500 GO:0033079 BP 1 immature T cell proliferation 1 A2VDJ0 453 1.00e-02 2 4 1 0.250 0.500 GO:0033084 BP 1 regulation of immature T cell proliferation in thymus 1 A2VDJ0 453 1.00e-02 2 4 1 0.250 0.500 GO:0033080 BP 1 immature T cell proliferation in thymus 1 A2VDJ0 453 1.50e-02 3 4 1 0.250 0.333 GO:0015791 BP 1 polyol transport 1 Q75T13 453 1.75e-02 7 4 1 0.250 0.143 REAC:162791 rea 1 Attachment of GPI anchor to uPAR 1 Q75T13 453 2.00e-02 4 4 1 0.250 0.250 GO:0006855 BP 1 drug transmembrane transport 1 Q9NV96 453 2.00e-02 4 4 1 0.250 0.250 GO:0033085 BP 1 negative regulation of T cell differentiation in thymus 1 A2VDJ0 453 2.00e-02 4 4 1 0.250 0.250 GO:2000399 BP 1 negative regulation of thymocyte aggregation 1 A2VDJ0 453 2.50e-02 5 4 1 0.250 0.200 GO:0016012 CC 1 sarcoglycan complex 1 Q16585 453 2.50e-02 5 4 1 0.250 0.200 GO:0016011 CC 1 dystroglycan complex 1 Q16585 453 3.50e-02 7 4 1 0.250 0.143 GO:0016255 BP 1 attachment of GPI anchor to protein 1 Q75T13 453 4.00e-02 8 4 1 0.250 0.125 GO:0070863 BP 1 positive regulation of protein exit from endoplasmic reticulum 1 Q9NV96 453 4.00e-02 8 4 1 0.250 0.125 GO:0015893 BP 1 drug transport 1 Q9NV96 453 5.00e-02 20 4 1 0.250 0.050 REAC:163125 rea 1 Post-translational modification: synthesis of GPI-anchored proteins 1 Q75T13 453 5.00e-02 5 4 1 0.250 0.200 HP:0001471 hp 1 Aplasia/Hypoplasia of the musculature of the pelvis 1 Q16585 453 5.00e-02 10 4 1 0.250 0.100 GO:0033081 BP 1 regulation of T cell differentiation in thymus 1 A2VDJ0 453 5.00e-02 10 4 1 0.250 0.100 GO:2000398 BP 1 regulation of thymocyte aggregation 1 A2VDJ0 453 5.00e-02 1674 4 4 1.000 0.002 TF:M00157_0 tf 1 Factor: RORalpha2; motif: NWAWNTAGGTCAN; match class: 0 1 Q9NV96,A2VDJ0,Q16585,Q75T13 453 5.00e-02 5 4 1 0.250 0.200 HP:0003707 hp 1 Calf muscle pseudohypertrophy 1 Q16585 453 5.00e-02 17 4 1 0.250 0.059 KEGG:00563 keg 1 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1 Q75T13 453 5.00e-02 5 4 1 0.250 0.200 HP:0008988 hp 1 Pelvic girdle muscle atrophy 1 Q16585 453 5.00e-02 3 4 1 0.250 0.333 CORUM:343 cor 1 Sarcoglycan-sarcospan complex SG-SPN 1 Q16585 453 5.00e-02 17 4 1 0.250 0.059 OMIM:253600 omi 1 Autosomal Recessive Limb-Girdle Muscular Dystrophy 1 Q16585 453 5.00e-02 10 4 1 0.250 0.100 GO:0045581 BP 1 negative regulation of T cell differentiation 1 A2VDJ0 454 1.61e-02 1369 2 2 1.000 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 Q9H8H0,Q13439 454 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 Q9H8H0,Q13439 454 2.14e-02 3 2 1 0.500 0.333 GO:0034455 CC 1 t-UTP complex 1 Q9H8H0 454 2.19e-02 1599 2 2 1.000 0.001 HPA:046030_03 hpa 1 tonsil; squamous epithelial cells[Uncertain,High] 1 Q9H8H0,Q13439 454 2.29e-02 1633 2 2 1.000 0.001 HPA:039040_02 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Medium] 1 Q9H8H0,Q13439 454 2.79e-02 1804 2 2 1.000 0.001 HPA:014010_03 hpa 1 esophagus; squamous epithelial cells[Uncertain,High] 1 Q9H8H0,Q13439 454 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 Q9H8H0,Q13439 454 3.71e-02 2079 2 2 1.000 0.001 HPA:006010_03 hpa 1 cerebellum; Purkinje cells[Uncertain,High] 1 Q9H8H0,Q13439 454 4.44e-02 2274 2 2 1.000 0.001 HPA:002010_03 hpa 1 appendix; glandular cells[Uncertain,High] 1 Q9H8H0,Q13439 454 4.48e-02 2286 2 2 1.000 0.001 HPA:011010_02 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,Medium] 1 Q9H8H0,Q13439 454 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q9H8H0,Q13439 454 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q13439 454 5.00e-02 47 2 1 0.500 0.021 REAC:6811440 rea 1 Retrograde transport at the Trans-Golgi-Network 1 Q13439 454 5.00e-02 475 2 2 1.000 0.004 MI:hsa-miR-425 mi 1 MI:hsa-miR-425 1 Q9H8H0,Q13439 454 5.00e-02 7 2 1 0.500 0.143 GO:1901838 BP 1 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter 1 Q9H8H0 454 5.00e-02 188 2 2 1.000 0.011 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 Q9H8H0,Q13439 455 1.10e-03 7 2 1 0.500 0.143 TF:M01138_1 tf 1 Factor: RORalpha; motif: WAANTRGGTCA; match class: 1 1 Q8NET4 455 3.14e-03 20 2 1 0.500 0.050 TF:M06147_0 tf 1 Factor: ZNF41; motif: NRATAAATGGGA; match class: 0 1 O43247 455 4.24e-03 27 2 1 0.500 0.037 TF:M07402_1 tf 1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 1 1 Q8NET4 455 4.87e-03 31 2 1 0.500 0.032 TF:M07095_1 tf 1 Factor: FOXP1; motif: NNNANGTAAACAAAN; match class: 1 1 Q8NET4 455 6.12e-03 39 2 1 0.500 0.026 TF:M04246_0 tf 1 Factor: FOXJ2; motif: GTAAACARTAAACA; match class: 0 1 Q8NET4 455 6.90e-03 44 2 1 0.500 0.023 TF:M06635_0 tf 1 Factor: znf607; motif: NCCTTGAAGGGM; match class: 0 1 Q8NET4 455 7.53e-03 48 2 1 0.500 0.021 TF:M06308_1 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 1 1 Q8NET4 455 8.31e-03 53 2 1 0.500 0.019 TF:M04003_0 tf 1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 0 1 O43247 455 1.07e-02 68 2 1 0.500 0.015 TF:M06425_0 tf 1 Factor: ZNF227; motif: NSAAGGGTGARA; match class: 0 1 Q8NET4 455 1.28e-02 82 2 1 0.500 0.012 TF:M05487_0 tf 1 Factor: ZNF542; motif: NRKGAGGGTAKT; match class: 0 1 O43247 455 1.52e-02 97 2 1 0.500 0.010 TF:M04005_0 tf 1 Factor: TCF7L1; motif: AAAGATCAAAGG; match class: 0 1 O43247 455 1.58e-02 1601 2 2 1.000 0.001 TF:M07362_0 tf 1 Factor: nanog; motif: CCATTAAAWNGTK; match class: 0 1 O43247,Q8NET4 455 1.61e-02 1616 2 2 1.000 0.001 TF:M03833_1 tf 1 Factor: NKX3A; motif: NCACTTANTYN; match class: 1 1 O43247,Q8NET4 455 1.61e-02 103 2 1 0.500 0.010 TF:M00264_1 tf 1 Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 1 1 Q8NET4 455 1.95e-02 1778 2 2 1.000 0.001 TF:M01821_1 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 1 1 O43247,Q8NET4 455 2.11e-02 1849 2 2 1.000 0.001 TF:M00193_1 tf 1 Factor: NF-1; motif: NNTTGGCNNNNNNCCNNN; match class: 1 1 O43247,Q8NET4 455 2.31e-02 1933 2 2 1.000 0.001 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 O43247,Q8NET4 455 2.72e-02 174 2 1 0.500 0.006 TF:M06320_0 tf 1 Factor: ZNF791; motif: NGGTTATGAMGA; match class: 0 1 Q8NET4 455 2.76e-02 177 2 1 0.500 0.006 TF:M00058_0 tf 1 Factor: HEN1; motif: NNGGGNCGCAGCTGCGNCCCNN; match class: 0 1 Q8NET4 455 3.10e-02 199 2 1 0.500 0.005 TF:M06027_0 tf 1 Factor: ZNF891; motif: NNMACAAGGCAA; match class: 0 1 Q8NET4 455 3.12e-02 200 2 1 0.500 0.005 TF:M07403_0 tf 1 Factor: FOXP2; motif: NWGTAAACARN; match class: 0 1 Q8NET4 455 3.47e-02 2372 2 2 1.000 0.001 TF:M04627_0 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 0 1 O43247,Q8NET4 455 3.55e-02 228 2 1 0.500 0.004 TF:M07084_0 tf 1 Factor: E2F-4; motif: NGGCGGGAARN; match class: 0 1 O43247 455 3.90e-02 2515 2 2 1.000 0.001 TF:M00624_1 tf 1 Factor: DBP; motif: AGCAHAC; match class: 1 1 O43247,Q8NET4 455 3.92e-02 252 2 1 0.500 0.004 TF:M04613_0 tf 1 Factor: HLTF; motif: AGSCARAAAGYRGSTGS; match class: 0 1 O43247 455 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 Q8NET4 455 4.11e-02 264 2 1 0.500 0.004 TF:M00415_1 tf 1 Factor: AREB6; motif: CBGTTTSNN; match class: 1 1 O43247 455 4.46e-02 2689 2 2 1.000 0.001 TF:M04144_0 tf 1 Factor: TEAD3; motif: RCATTCCW; match class: 0 1 O43247,Q8NET4 455 4.54e-02 292 2 1 0.500 0.003 TF:M04255_1 tf 1 Factor: FOXO1; motif: GTAAACAW; match class: 1 1 Q8NET4 455 4.54e-02 292 2 1 0.500 0.003 TF:M04247_1 tf 1 Factor: FOXJ2; motif: RTAAACAA; match class: 1 1 Q8NET4 455 4.54e-02 292 2 1 0.500 0.003 TF:M04259_1 tf 1 Factor: FOXO3; motif: GTAAACAW; match class: 1 1 Q8NET4 455 4.81e-02 2793 2 2 1.000 0.001 TF:M03847_0 tf 1 Factor: Sox15; motif: ACAAWGGG; match class: 0 1 O43247,Q8NET4 455 4.86e-02 313 2 1 0.500 0.003 TF:M04627_1 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 1 1 Q8NET4 455 4.88e-02 2813 2 2 1.000 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 O43247,Q8NET4 456 4.44e-05 45 2 2 1.000 0.044 GO:0006073 BP 1 cellular glucan metabolic process 1 O95278,O95210 456 4.44e-05 45 2 2 1.000 0.044 GO:0005977 BP 1 glycogen metabolic process 1 O95278,O95210 456 4.44e-05 45 2 2 1.000 0.044 GO:0044042 BP 1 glucan metabolic process 1 O95278,O95210 456 5.50e-05 50 2 2 1.000 0.040 GO:0006112 BP 1 energy reserve metabolic process 1 O95278,O95210 456 6.91e-05 56 2 2 1.000 0.036 GO:0044264 BP 1 cellular polysaccharide metabolic process 1 O95278,O95210 456 9.63e-05 66 2 2 1.000 0.030 GO:0005976 BP 1 polysaccharide metabolic process 1 O95278,O95210 456 3.53e-04 126 2 2 1.000 0.016 GO:0044262 BP 1 cellular carbohydrate metabolic process 1 O95278,O95210 456 7.31e-04 181 2 2 1.000 0.011 GO:0015980 BP 1 energy derivation by oxidation of organic compounds 1 O95278,O95210 456 1.04e-03 2 2 1 0.500 0.500 GO:2001069 MF 1 glycogen binding 1 O95210 456 1.04e-03 2 2 1 0.500 0.500 GO:0061723 BP 1 glycophagy 1 O95210 456 1.48e-03 257 2 2 1.000 0.008 GO:0006091 BP 1 generation of precursor metabolites and energy 1 O95278,O95210 456 1.72e-03 277 2 2 1.000 0.007 GO:0044723 BP 1 single-organism carbohydrate metabolic process 1 O95278,O95210 456 2.35e-03 324 2 2 1.000 0.006 GO:0005975 BP 1 carbohydrate metabolic process 1 O95278,O95210 456 3.11e-03 6 2 1 0.500 0.167 GO:0030247 MF 1 polysaccharide binding 1 O95210 456 3.11e-03 6 2 1 0.500 0.167 GO:0001871 MF 1 pattern binding 1 O95210 456 3.15e-03 375 2 2 1.000 0.005 GO:0055114 BP 1 oxidation-reduction process 1 O95278,O95210 456 3.62e-03 7 2 1 0.500 0.143 GO:0019203 MF 1 carbohydrate phosphatase activity 1 O95278 456 5.87e-03 9 2 1 0.500 0.111 REAC:5663084 rea 1 Diseases of carbohydrate metabolism 1 O95278 456 5.87e-03 9 2 1 0.500 0.111 REAC:3785653 rea 1 Myoclonic epilepsy of Lafora 1 O95278 456 5.87e-03 9 2 1 0.500 0.111 REAC:3229121 rea 1 Glycogen storage diseases 1 O95278 456 8.79e-03 17 2 1 0.500 0.059 GO:0005980 BP 1 glycogen catabolic process 1 O95210 456 8.79e-03 17 2 1 0.500 0.059 GO:0044247 BP 1 cellular polysaccharide catabolic process 1 O95210 456 8.79e-03 17 2 1 0.500 0.059 GO:0000272 BP 1 polysaccharide catabolic process 1 O95210 456 8.79e-03 17 2 1 0.500 0.059 GO:0009251 BP 1 glucan catabolic process 1 O95210 456 9.13e-03 14 2 1 0.500 0.071 REAC:3322077 rea 1 Glycogen synthesis 1 O95278 456 1.40e-02 27 2 1 0.500 0.037 GO:0044275 BP 1 cellular carbohydrate catabolic process 1 O95210 456 1.55e-02 30 2 1 0.500 0.033 GO:0005844 CC 1 polysome 1 O95278 456 1.60e-02 31 2 1 0.500 0.032 GO:0005978 BP 1 glycogen biosynthetic process 1 O95278 456 1.60e-02 31 2 1 0.500 0.032 GO:0009250 BP 1 glucan biosynthetic process 1 O95278 456 2.17e-02 42 2 1 0.500 0.024 GO:0033692 BP 1 cellular polysaccharide biosynthetic process 1 O95278 456 2.21e-02 34 2 1 0.500 0.029 REAC:5668914 rea 1 Diseases of metabolism 1 O95278 456 2.53e-02 49 2 1 0.500 0.020 GO:0000271 BP 1 polysaccharide biosynthetic process 1 O95278 456 2.53e-02 49 2 1 0.500 0.020 GO:0034637 BP 1 cellular carbohydrate biosynthetic process 1 O95278 456 2.69e-02 52 2 1 0.500 0.019 GO:0030246 MF 1 carbohydrate binding 1 O95210 456 2.79e-02 54 2 1 0.500 0.019 GO:0004722 MF 1 protein serine/threonine phosphatase activity 1 O95278 456 3.10e-02 60 2 1 0.500 0.017 GO:0004725 MF 1 protein tyrosine phosphatase activity 1 O95278 456 3.33e-02 2 2 1 0.500 0.500 HP:0011165 hp 1 Visual auras 1 O95278 456 4.45e-02 252 2 1 0.500 0.004 MI:hsa-miR-130b* mi 1 MI:hsa-miR-130b* 1 O95210 456 5.00e-02 2 2 1 0.500 0.500 TF:M06717_0 tf 1 Factor: ZFP; motif: NAGGGCCGGATM; match class: 0 1 O95210 456 5.00e-02 97 2 1 0.500 0.010 GO:0044724 BP 1 single-organism carbohydrate catabolic process 1 O95210 456 5.00e-02 3 2 1 0.500 0.333 HP:0011157 hp 1 Auras 1 O95278 456 5.00e-02 2 2 1 0.500 0.500 OMIM:254780 omi 1 MYOCLONIC EPILEPSY OF LAFORA;;MELF;;LAFORA DISEASE;;LAFORA BODY DISEASE; LBD;;EPILEPSY, PROGRESSIVE MYOCLONIC, 2A; EPM2A;;EPM2EPILEPSY, PROGRESSIVE MYOCLONIC, 2B, INCLUDED; EPM2B, INCLUDED 1 O95278 457 2.47e-03 537 2 2 1.000 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 3.04e-03 596 2 2 1.000 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 3.35e-03 625 2 2 1.000 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 3.41e-03 631 2 2 1.000 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 3.58e-03 1 2 1 0.500 1.000 OMIM:607832 omi 1 FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO; FSGS3;;GLOMERULOSCLEROSIS, FOCAL SEGMENTAL, 3, SUSCEPTIBILITY TO 1 Q9Y5K6 457 4.18e-03 271 2 2 1.000 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q9Y266,Q9Y5K6 457 4.30e-03 275 2 2 1.000 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q9Y266,Q9Y5K6 457 4.37e-03 277 2 2 1.000 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q9Y266,Q9Y5K6 457 4.53e-03 282 2 2 1.000 0.007 GO:0045296 MF 1 cadherin binding 1 Q9Y266,Q9Y5K6 457 4.92e-03 294 2 2 1.000 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 Q9Y266,Q9Y5K6 457 5.18e-03 33 2 1 0.500 0.030 TF:M05895_0 tf 1 Factor: ZNF454; motif: KGGTAYAKAATC; match class: 0 1 Q9Y266 457 6.55e-03 874 2 2 1.000 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 6.90e-03 44 2 1 0.500 0.023 TF:M04043_0 tf 1 Factor: MYBL1; motif: ACCGTTAACSGY; match class: 0 1 Q9Y266 457 7.76e-03 369 2 2 1.000 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 Q9Y266,Q9Y5K6 457 7.91e-03 6 2 1 0.500 0.167 GO:0006930 BP 1 substrate-dependent cell migration, cell extension 1 Q9Y5K6 457 9.56e-03 61 2 1 0.500 0.016 TF:M00766_0 tf 1 Factor: LXR; motif: TGACCGNNAGTRACCC; match class: 0 1 Q9Y266 457 9.96e-03 1078 2 2 1.000 0.002 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 Q9Y266,Q9Y5K6 457 1.01e-02 420 2 2 1.000 0.005 GO:0005911 CC 1 cell-cell junction 1 Q9Y266,Q9Y5K6 457 1.08e-02 69 2 1 0.500 0.014 TF:M06263_0 tf 1 Factor: ZNF211; motif: NGTGACWAAGSM; match class: 0 1 Q9Y266 457 1.19e-02 76 2 1 0.500 0.013 TF:M04176_0 tf 1 Factor: MAX; motif: NNCACGTGNN; match class: 0 1 Q9Y266 457 1.19e-02 76 2 1 0.500 0.013 TF:M04087_1 tf 1 Factor: POU4F3; motif: NTGMATWATTAATGNN; match class: 1 1 Q9Y5K6 457 1.22e-02 78 2 1 0.500 0.013 TF:M05949_0 tf 1 Factor: ZNF714; motif: NGGGAAGGAAGM; match class: 0 1 Q9Y266 457 1.25e-02 1422 2 2 1.000 0.001 TF:M01882_0 tf 1 Factor: IRF-2; motif: NNRAAAGTGAAASNNA; match class: 0 1 Q9Y266,Q9Y5K6 457 1.32e-02 1241 2 2 1.000 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q9Y266,Q9Y5K6 457 1.33e-02 85 2 1 0.500 0.012 TF:M00236_0 tf 1 Factor: Arnt; motif: NDDNNCACGTGNNNNN; match class: 0 1 Q9Y266 457 1.33e-02 1247 2 2 1.000 0.002 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.55e-02 1584 2 2 1.000 0.001 TF:M00284_0 tf 1 Factor: TCF11:MafG; motif: NNNNNATGACTCAGCANTTNNG; match class: 0 1 Q9Y266,Q9Y5K6 457 1.59e-02 1360 2 2 1.000 0.001 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.70e-02 1408 2 2 1.000 0.001 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.78e-02 1440 2 2 1.000 0.001 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9Y266,Q9Y5K6 457 1.81e-02 1453 2 2 1.000 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.84e-02 14 2 1 0.500 0.071 GO:0006929 BP 1 substrate-dependent cell migration 1 Q9Y5K6 457 1.85e-02 1470 2 2 1.000 0.001 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.87e-02 1740 2 2 1.000 0.001 TF:M04412_1 tf 1 Factor: NKX2-8; motif: NCACTTSAN; match class: 1 1 Q9Y266,Q9Y5K6 457 1.89e-02 1748 2 2 1.000 0.001 TF:M07313_1 tf 1 Factor: ATF-3; motif: SNTGACGYNATN; match class: 1 1 Q9Y266,Q9Y5K6 457 1.93e-02 1499 2 2 1.000 0.001 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.93e-02 582 2 2 1.000 0.003 GO:0005912 CC 1 adherens junction 1 Q9Y266,Q9Y5K6 457 1.94e-02 124 2 1 0.500 0.008 TF:M06124_0 tf 1 Factor: ZNF806; motif: GGTWRAAACSM; match class: 0 1 Q9Y266 457 1.96e-02 1513 2 2 1.000 0.001 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 1.97e-02 1516 2 2 1.000 0.001 HPA:011020_03 hpa 1 endometrium 1; glandular cells[Uncertain,High] 1 Q9Y266,Q9Y5K6 457 1.99e-02 591 2 2 1.000 0.003 GO:0070161 CC 1 anchoring junction 1 Q9Y266,Q9Y5K6 457 2.02e-02 1535 2 2 1.000 0.001 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.06e-02 1550 2 2 1.000 0.001 HPA:003010_03 hpa 1 bone marrow; hematopoietic cells[Uncertain,High] 1 Q9Y266,Q9Y5K6 457 2.08e-02 1559 2 2 1.000 0.001 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.12e-02 1574 2 2 1.000 0.001 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.14e-02 137 2 1 0.500 0.007 TF:M06701_0 tf 1 Factor: ZNF319; motif: NGGTWAAACCGA; match class: 0 1 Q9Y5K6 457 2.17e-02 1589 2 2 1.000 0.001 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.17e-02 1589 2 2 1.000 0.001 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.20e-02 1600 2 2 1.000 0.001 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.25e-02 1619 2 2 1.000 0.001 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.26e-02 1622 2 2 1.000 0.001 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.36e-02 1659 2 2 1.000 0.001 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.39e-02 153 2 1 0.500 0.007 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 Q9Y266 457 2.39e-02 153 2 1 0.500 0.007 TF:M03809_0 tf 1 Factor: LXR-beta:RXR-alpha; motif: NNTGACCKNCAGTGACCYCN; match class: 0 1 Q9Y266 457 2.48e-02 159 2 1 0.500 0.006 TF:M06290_0 tf 1 Factor: Cos52; motif: NGGTCCDCCWGW; match class: 0 1 Q9Y5K6 457 2.49e-02 1704 2 2 1.000 0.001 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.58e-02 2044 2 2 1.000 0.001 TF:M04326_0 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 0 1 Q9Y266,Q9Y5K6 457 2.62e-02 168 2 1 0.500 0.006 TF:M00804_1 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 1 1 Q9Y266 457 2.64e-02 169 2 1 0.500 0.006 TF:M04085_1 tf 1 Factor: POU4F1; motif: NTGMATAATTAATG; match class: 1 1 Q9Y5K6 457 2.67e-02 1765 2 2 1.000 0.001 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.72e-02 1780 2 2 1.000 0.001 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.72e-02 1782 2 2 1.000 0.001 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.74e-02 1788 2 2 1.000 0.001 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.75e-02 176 2 1 0.500 0.006 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 Q9Y5K6 457 2.77e-02 21 2 1 0.500 0.048 GO:0031941 CC 1 filamentous actin 1 Q9Y5K6 457 2.77e-02 1797 2 2 1.000 0.001 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.79e-02 1802 2 2 1.000 0.001 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.82e-02 1813 2 2 1.000 0.001 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.83e-02 1818 2 2 1.000 0.001 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.84e-02 1820 2 2 1.000 0.001 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.86e-02 1825 2 2 1.000 0.001 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 2.89e-02 2166 2 2 1.000 0.001 TF:M03891_1 tf 1 Factor: TTF-1; motif: CTTGASN; match class: 1 1 Q9Y266,Q9Y5K6 457 2.96e-02 1857 2 2 1.000 0.001 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 2.98e-02 1863 2 2 1.000 0.001 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.03e-02 1880 2 2 1.000 0.001 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.04e-02 1883 2 2 1.000 0.001 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.11e-02 1904 2 2 1.000 0.001 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.13e-02 1909 2 2 1.000 0.001 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.18e-02 746 2 2 1.000 0.003 GO:0030054 CC 1 cell junction 1 Q9Y266,Q9Y5K6 457 3.18e-02 1924 2 2 1.000 0.001 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.18e-02 14 2 1 0.500 0.071 REAC:68884 rea 1 Mitotic Telophase/Cytokinesis 1 Q9Y266 457 3.26e-02 1950 2 2 1.000 0.001 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.34e-02 1974 2 2 1.000 0.001 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.38e-02 1986 2 2 1.000 0.001 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.42e-02 1996 2 2 1.000 0.001 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.42e-02 1998 2 2 1.000 0.001 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.51e-02 2024 2 2 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.52e-02 226 2 1 0.500 0.004 TF:M06689_0 tf 1 Factor: ZNF319; motif: NTMTWAAGGCTC; match class: 0 1 Q9Y266 457 3.57e-02 2039 2 2 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.60e-02 2049 2 2 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.61e-02 2051 2 2 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.62e-02 2055 2 2 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.68e-02 2071 2 2 1.000 0.001 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.68e-02 2072 2 2 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.73e-02 2086 2 2 1.000 0.001 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.75e-02 2092 2 2 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.78e-02 243 2 1 0.500 0.004 TF:M05454_0 tf 1 Factor: ZBTB3; motif: KGGTKYCAAC; match class: 0 1 Q9Y266 457 3.79e-02 2478 2 2 1.000 0.001 TF:M07387_1 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 1 1 Q9Y266,Q9Y5K6 457 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.82e-02 2110 2 2 1.000 0.001 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 3.89e-02 2130 2 2 1.000 0.001 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.94e-02 2526 2 2 1.000 0.001 TF:M01797_0 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 0 1 Q9Y266,Q9Y5K6 457 3.94e-02 2527 2 2 1.000 0.001 TF:M02085_0 tf 1 Factor: Bcl-6; motif: NTTYCTAGRA; match class: 0 1 Q9Y266,Q9Y5K6 457 3.97e-02 2151 2 2 1.000 0.001 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 3.98e-02 2153 2 2 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.00e-02 2159 2 2 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.03e-02 2168 2 2 1.000 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.05e-02 2173 2 2 1.000 0.001 HPA:015010_03 hpa 1 fallopian tube; glandular cells[Uncertain,High] 1 Q9Y266,Q9Y5K6 457 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.09e-02 2183 2 2 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.12e-02 2191 2 2 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.14e-02 266 2 1 0.500 0.004 TF:M03795_0 tf 1 Factor: LXR;; motif: NTGACCKNNAGTRACCYNN; match class: 0 1 Q9Y266 457 4.14e-02 2197 2 2 1.000 0.001 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.19e-02 2209 2 2 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.25e-02 2227 2 2 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 Q9Y266,Q9Y5K6 457 4.26e-02 274 2 1 0.500 0.004 TF:M00622_1 tf 1 Factor: C/EBPgamma; motif: YTBATTTCARAAW; match class: 1 1 Q9Y5K6 457 4.40e-02 283 2 1 0.500 0.004 TF:M00073_1 tf 1 Factor: deltaEF1; motif: NNNCACCTNAN; match class: 1 1 Q9Y5K6 457 4.42e-02 2270 2 2 1.000 0.001 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.42e-02 2271 2 2 1.000 0.001 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.44e-02 2274 2 2 1.000 0.001 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.44e-02 2276 2 2 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.46e-02 2281 2 2 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.48e-02 2286 2 2 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.54e-02 292 2 1 0.500 0.003 TF:M04106_0 tf 1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 0 1 Q9Y266 457 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.69e-02 302 2 1 0.500 0.003 TF:M00965_1 tf 1 Factor: LXR,; motif: YGAMCTNNASTRACCYN; match class: 1 1 Q9Y266 457 4.71e-02 2342 2 2 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.78e-02 308 2 1 0.500 0.003 TF:M07305_1 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 1 1 Q9Y266 457 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.83e-02 2797 2 2 1.000 0.001 TF:M00731_0 tf 1 Factor: Osf2; motif: ACCACANM; match class: 0 1 Q9Y266,Q9Y5K6 457 4.86e-02 313 2 1 0.500 0.003 TF:M03865_0 tf 1 Factor: Blimp-1; motif: NRGRAAGKGAAAGK; match class: 0 1 Q9Y266 457 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 Q9Y266,Q9Y5K6 457 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q9Y5K6 457 5.00e-02 73 2 1 0.500 0.014 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 Q9Y5K6 457 5.00e-02 15 2 1 0.500 0.067 HP:0000097 hp 1 Focal segmental glomerulosclerosis 1 Q9Y5K6 457 5.00e-02 9 2 1 0.500 0.111 CORUM:846 cor 1 RICH1/AMOT polarity complex, Flag-Rich1 precipitated 1 Q9Y5K6 457 5.00e-02 38 2 1 0.500 0.026 GO:0017124 MF 1 SH3 domain binding 1 Q9Y5K6 457 5.00e-02 22 2 1 0.500 0.045 REAC:373753 rea 1 Nephrin interactions 1 Q9Y5K6 457 5.00e-02 14 2 1 0.500 0.071 OMIM:603278 omi 1 Focal Segmental Glomerulosclerosis and Nephrotic Syndrome 1 Q9Y5K6 458 2.50e-04 19 5 2 0.400 0.105 GO:0019054 BP 1 modulation by virus of host process 1 O00505,O00629 458 3.07e-04 21 5 2 0.400 0.095 GO:0006607 BP 1 NLS-bearing protein import into nucleus 1 O00505,O00629 458 3.38e-04 22 5 2 0.400 0.091 GO:0008139 MF 1 nuclear localization sequence binding 1 O00505,O00629 458 3.38e-04 22 5 2 0.400 0.091 GO:0044068 BP 1 modulation by symbiont of host cellular process 1 O00505,O00629 458 6.36e-04 30 5 2 0.400 0.067 GO:0019048 BP 1 modulation by virus of host morphology or physiology 1 O00505,O00629 458 6.77e-04 39 5 2 0.400 0.051 REAC:168276 rea 1 NS1 Mediated Effects on Host Pathways 1 O00505,O00629 458 7.48e-04 41 5 2 0.400 0.049 REAC:168253 rea 1 Host Interactions with Influenza Factors 1 O00505,O00629 458 8.19e-04 34 5 2 0.400 0.059 GO:0005048 MF 1 signal sequence binding 1 O00505,O00629 458 9.20e-04 36 5 2 0.400 0.056 GO:0044003 BP 1 modification by symbiont of host morphology or physiology 1 O00505,O00629 458 1.94e-03 66 5 2 0.400 0.030 REAC:1169408 rea 1 ISG15 antiviral mechanism 1 O00505,O00629 458 1.94e-03 66 5 2 0.400 0.030 REAC:1169410 rea 1 Antiviral mechanism by IFN-stimulated genes 1 O00505,O00629 458 2.66e-03 61 5 2 0.400 0.033 GO:0005643 CC 1 nuclear pore 1 O00505,O00629 458 2.84e-03 63 5 2 0.400 0.032 GO:0051817 BP 1 modification of morphology or physiology of other organism involved in symbiotic interaction 1 O00505,O00629 458 3.02e-03 65 5 2 0.400 0.031 GO:0075733 BP 1 intracellular transport of virus 1 O00505,O00629 458 3.12e-03 66 5 2 0.400 0.030 GO:0035821 BP 1 modification of morphology or physiology of other organism 1 O00505,O00629 458 3.12e-03 66 5 2 0.400 0.030 GO:1902583 BP 1 multi-organism intracellular transport 1 O00505,O00629 458 3.12e-03 66 5 2 0.400 0.030 GO:1902581 BP 1 multi-organism cellular localization 1 O00505,O00629 458 3.21e-03 67 5 2 0.400 0.030 GO:0008565 MF 1 protein transporter activity 1 O00505,O00629 458 3.21e-03 67 5 2 0.400 0.030 GO:0046794 BP 1 transport of virus 1 O00505,O00629 458 3.51e-03 70 5 2 0.400 0.029 GO:0044766 BP 1 multi-organism transport 1 O00505,O00629 458 3.51e-03 70 5 2 0.400 0.029 GO:1902579 BP 1 multi-organism localization 1 O00505,O00629 458 6.78e-03 485 5 3 0.600 0.006 GO:0072594 BP 1 establishment of protein localization to organelle 1 Q7Z6Z7,O00505,O00629 458 6.86e-03 487 5 3 0.600 0.006 GO:0006605 BP 1 protein targeting 1 Q7Z6Z7,O00505,O00629 458 6.87e-03 98 5 2 0.400 0.020 GO:0051701 BP 1 interaction with host 1 O00505,O00629 458 8.47e-03 2 5 1 0.200 0.500 GO:0048408 MF 1 epidermal growth factor binding 1 O43847 458 9.64e-03 148 5 2 0.400 0.014 REAC:913531 rea 1 Interferon Signaling 1 O00505,O00629 458 9.77e-03 117 5 2 0.400 0.017 GO:0042277 MF 1 peptide binding 1 O00505,O00629 458 1.00e-02 151 5 2 0.400 0.013 REAC:168254 rea 1 Influenza Infection 1 O00505,O00629 458 1.19e-02 129 5 2 0.400 0.016 GO:0033218 MF 1 amide binding 1 O00505,O00629 458 1.65e-02 657 5 3 0.600 0.005 GO:0033365 BP 1 protein localization to organelle 1 Q7Z6Z7,O00505,O00629 458 1.88e-02 3 5 1 0.200 0.333 CORUM:220 cor 1 ARF-Mule complex 1 Q7Z6Z7 458 1.98e-02 167 5 2 0.400 0.012 GO:1902593 BP 1 single-organism nuclear import 1 O00505,O00629 458 1.98e-02 167 5 2 0.400 0.012 GO:0006606 BP 1 protein import into nucleus 1 O00505,O00629 458 1.98e-02 167 5 2 0.400 0.012 GO:0044744 BP 1 protein targeting to nucleus 1 O00505,O00629 458 2.02e-02 509 5 2 0.400 0.004 HPA:018010_03 hpa 1 hippocampus; glial cells[Uncertain,High] 1 O00505,O00629 458 2.06e-02 709 5 3 0.600 0.004 GO:0006886 BP 1 intracellular protein transport 1 Q7Z6Z7,O00505,O00629 458 2.40e-02 184 5 2 0.400 0.011 GO:0051170 BP 1 nuclear import 1 O00505,O00629 458 3.05e-02 208 5 2 0.400 0.010 GO:0017038 BP 1 protein import 1 O00505,O00629 458 3.37e-02 5480 5 5 1.000 0.001 HPA:035010_01 hpa 1 skin 1; Langerhans[Uncertain,Low] 1 O43847,Q7Z6Z7,O00505,Q9H165,O00629 458 3.44e-02 221 5 2 0.400 0.009 GO:0034504 BP 1 protein localization to nucleus 1 O00505,O00629 458 3.70e-02 14 5 1 0.200 0.071 HP:0010472 hp 1 Abnormality of the heme biosynthetic pathway 1 Q9H165 458 4.17e-02 244 5 2 0.400 0.008 GO:0005635 CC 1 nuclear envelope 1 O00505,O00629 458 4.19e-02 3523 5 4 0.800 0.001 HPA:039040_01 hpa 1 soft tissue 1; peripheral nerve[Uncertain,Low] 1 O43847,Q7Z6Z7,O00505,O00629 458 4.65e-02 11 5 1 0.200 0.091 GO:0051044 BP 1 positive regulation of membrane protein ectodomain proteolysis 1 O43847 458 4.80e-02 2013 5 3 0.600 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 O43847,O00505,O00629 458 4.88e-02 3675 5 4 0.800 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 O43847,Q7Z6Z7,O00505,O00629 458 5.00e-02 964 5 3 0.600 0.003 GO:0015031 BP 1 protein transport 1 Q7Z6Z7,O00505,O00629 458 5.00e-02 19 5 1 0.200 0.053 HP:0011904 hp 1 Persistence of hemoglobin F 1 Q9H165 458 5.00e-02 346 5 2 0.400 0.006 REAC:5663205 rea 1 Infectious disease 1 O00505,O00629 458 5.00e-02 8 5 1 0.200 0.125 CORUM:1728 cor 1 CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex 1 O00505 458 5.00e-02 482 5 3 0.600 0.006 MI:hsa-miR-191 mi 1 MI:hsa-miR-191 1 O43847,Q9H165,O00629 458 5.00e-02 1 5 1 0.200 1.000 OMIM:300706 omi 1 MENTAL RETARDATION, X-LINKED, SYNDROMIC, TURNER TYPE; MRXST;;MENTAL RETARDATION AND MACROCEPHALY SYNDROME 1 Q7Z6Z7 458 5.00e-02 385 5 3 0.600 0.008 TF:M06040_0 tf 1 Factor: ZNF705F; motif: NCCAAAAAAAYY; match class: 0 1 O43847,Q7Z6Z7,O00505 459 3.13e-03 1 4 1 0.250 1.000 GO:0031849 MF 1 olfactory receptor binding 1 Q9H902 459 5.58e-03 1 4 1 0.250 1.000 OMIM:614751 omi 1 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE VB; HMN5B;;HMN VB;;NEUROPATHY, DISTAL HEREDITARY MOTOR, TYPE VB; DHMN5B;;DHMN VB;;SPINAL MUSCULAR ATROPHY, DISTAL, TYPE VB; DSMAVB 1 Q9H902 459 5.58e-03 1 4 1 0.250 1.000 OMIM:610250 omi 1 SPASTIC PARAPLEGIA 31, AUTOSOMAL DOMINANT; SPG31 1 Q9H902 459 6.55e-03 379 4 2 0.500 0.005 MI:hsa-miR-654-3p mi 1 MI:hsa-miR-654-3p 1 Q9H902,Q9UMS5 459 8.12e-03 423 4 2 0.500 0.005 MI:hsa-miR-628-3p mi 1 MI:hsa-miR-628-3p 1 Q9UMS5,O95274 459 8.73e-03 439 4 2 0.500 0.005 MI:mmu-miR-699 mi 1 MI:mmu-miR-699 1 Q9UMS5,O95274 459 1.07e-02 488 4 2 0.500 0.004 MI:hsa-miR-27a mi 1 MI:hsa-miR-27a 1 Q9UMS5,O95274 459 1.12e-02 499 4 2 0.500 0.004 MI:hsa-miR-582-5p mi 1 MI:hsa-miR-582-5p 1 Q8N3S3,Q9UMS5 459 1.19e-02 515 4 2 0.500 0.004 MI:hsa-miR-30a mi 1 MI:hsa-miR-30a 1 Q9H902,Q9UMS5 459 1.23e-02 524 4 2 0.500 0.004 MI:hsa-miR-30e mi 1 MI:hsa-miR-30e 1 Q9H902,Q9UMS5 459 1.28e-02 534 4 2 0.500 0.004 MI:hsa-miR-455-3p mi 1 MI:hsa-miR-455-3p 1 Q9UMS5,O95274 459 1.29e-02 537 4 2 0.500 0.004 MI:hsa-miR-30c mi 1 MI:hsa-miR-30c 1 Q8N3S3,Q9UMS5 459 1.78e-02 635 4 2 0.500 0.003 MI:hsa-miR-519a mi 1 MI:hsa-miR-519a 1 Q8N3S3,Q9UMS5 459 1.80e-02 638 4 2 0.500 0.003 MI:hsa-miR-519c-3p mi 1 MI:hsa-miR-519c-3p 1 Q8N3S3,Q9UMS5 459 3.21e-02 832 4 2 0.500 0.002 HPA:009030_03 hpa 1 colon; peripheral nerve/ganglion[Uncertain,High] 1 Q8N3S3,Q9H902 459 3.44e-02 11 4 1 0.250 0.091 GO:0071786 BP 1 endoplasmic reticulum tubular network organization 1 Q9H902 459 4.06e-02 13 4 1 0.250 0.077 GO:0071782 CC 1 endoplasmic reticulum tubular network 1 Q9H902 459 4.38e-02 14 4 1 0.250 0.071 GO:0046658 CC 1 anchored component of plasma membrane 1 O95274 459 4.69e-02 15 4 1 0.250 0.067 GO:0043236 MF 1 laminin binding 1 O95274 459 4.69e-02 15 4 1 0.250 0.067 GO:0098827 CC 1 endoplasmic reticulum subcompartment 1 Q9H902 459 5.00e-02 3 4 1 0.250 0.333 HP:0003426 hp 1 First dorsal interossei muscle atrophy 1 Q9H902 459 5.00e-02 3 4 1 0.250 0.333 HP:0003392 hp 1 First dorsal interossei muscle weakness 1 Q9H902 459 5.00e-02 3 4 1 0.250 0.333 HP:0003435 hp 1 Cold-induced hand cramps 1 Q9H902 459 5.00e-02 16 4 1 0.250 0.062 GO:0031225 CC 1 anchored component of membrane 1 O95274 459 5.00e-02 98 4 2 0.500 0.020 TF:M07050_1 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 1 1 Q8N3S3,Q9H902 459 5.00e-02 3 4 1 0.250 0.333 HP:0003449 hp 1 Cold-induced muscle cramps 1 Q9H902 459 5.00e-02 3 4 1 0.250 0.333 HP:0003427 hp 1 Thenar muscle weakness 1 Q9H902 460 2.07e-03 580 2 2 1.000 0.003 TF:M04232_0 tf 1 Factor: FOXC1; motif: AARTAAAYAAACA; match class: 0 1 O75391,P36543 460 3.68e-03 773 2 2 1.000 0.003 TF:M07204_0 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 0 1 O75391,P36543 460 5.02e-03 32 2 1 0.500 0.031 TF:M05757_0 tf 1 Factor: ZNF648; motif: NGKGGCAGAATS; match class: 0 1 P36543 460 1.07e-02 68 2 1 0.500 0.015 TF:M07223_1 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 1 1 P36543 460 1.12e-02 1345 2 2 1.000 0.001 TF:M07050_0 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 0 1 O75391,P36543 460 1.36e-02 87 2 1 0.500 0.011 TF:M07204_1 tf 1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 1 P36543 460 1.42e-02 1519 2 2 1.000 0.001 TF:M04236_0 tf 1 Factor: FOXC2; motif: RTAAAYAAACA; match class: 0 1 O75391,P36543 460 1.61e-02 1614 2 2 1.000 0.001 TF:M04254_0 tf 1 Factor: FOXL1; motif: NRTAAAYAAACAN; match class: 0 1 O75391,P36543 460 1.75e-02 112 2 1 0.500 0.009 TF:M04363_1 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 1 1 P36543 460 1.75e-02 112 2 1 0.500 0.009 TF:M04357_1 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 1 1 P36543 460 1.98e-02 1793 2 2 1.000 0.001 TF:M04122_1 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 1 1 O75391,P36543 460 1.98e-02 1793 2 2 1.000 0.001 TF:M04135_1 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 1 1 O75391,P36543 460 1.98e-02 1793 2 2 1.000 0.001 TF:M04137_1 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 1 1 O75391,P36543 460 1.98e-02 1793 2 2 1.000 0.001 TF:M04117_1 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 1 1 O75391,P36543 460 1.98e-02 1793 2 2 1.000 0.001 TF:M04126_1 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 1 1 O75391,P36543 460 2.11e-02 135 2 1 0.500 0.007 TF:M06508_0 tf 1 Factor: ZNF114; motif: GGCCGGSTAA; match class: 0 1 O75391 460 2.11e-02 135 2 1 0.500 0.007 TF:M05362_0 tf 1 Factor: NKX1-1; motif: WTAATAWGGA; match class: 0 1 P36543 460 2.22e-02 23 2 1 0.500 0.043 KEGG:04966 keg 1 Collecting duct acid secretion 1 P36543 460 2.27e-02 24 2 1 0.500 0.042 GO:0090383 BP 1 phagosome acidification 1 P36543 460 2.31e-02 1933 2 2 1.000 0.001 TF:M07294_0 tf 1 Factor: KLF8; motif: HMNDGGGTGT; match class: 0 1 O75391,P36543 460 2.47e-02 158 2 1 0.500 0.006 TF:M05893_0 tf 1 Factor: ZNF676; motif: NSAGGGGGCGGT; match class: 0 1 O75391 460 2.61e-02 2057 2 2 1.000 0.001 TF:M00482_0 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 0 1 O75391,P36543 460 2.64e-02 2070 2 2 1.000 0.001 TF:M05961_0 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 0 1 O75391,P36543 460 2.72e-02 174 2 1 0.500 0.006 TF:M07137_1 tf 1 Factor: AP-2gamma; motif: NNNNSCCYCAGGSCN; match class: 1 1 O75391 460 2.83e-02 2140 2 2 1.000 0.001 TF:M03572_1 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 1 1 O75391,P36543 460 2.83e-02 30 2 1 0.500 0.033 GO:0051452 BP 1 intracellular pH reduction 1 P36543 460 2.83e-02 30 2 1 0.500 0.033 GO:0015682 BP 1 ferric iron transport 1 P36543 460 2.83e-02 30 2 1 0.500 0.033 GO:0033572 BP 1 transferrin transport 1 P36543 460 2.83e-02 30 2 1 0.500 0.033 GO:0072512 BP 1 trivalent inorganic cation transport 1 P36543 460 2.93e-02 31 2 1 0.500 0.032 GO:0090382 BP 1 phagosome maturation 1 P36543 460 2.93e-02 31 2 1 0.500 0.032 GO:0045851 BP 1 pH reduction 1 P36543 460 2.94e-02 2181 2 2 1.000 0.001 TF:M03890_0 tf 1 Factor: TFEA; motif: GYCASVTGACYN; match class: 0 1 O75391,P36543 460 2.98e-02 22 2 1 0.500 0.045 REAC:77387 rea 1 Insulin receptor recycling 1 P36543 460 3.21e-02 34 2 1 0.500 0.029 GO:0016469 CC 1 proton-transporting two-sector ATPase complex 1 P36543 460 3.28e-02 2305 2 2 1.000 0.001 TF:M00289_1 tf 1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 1 O75391,P36543 460 3.38e-02 25 2 1 0.500 0.040 REAC:917977 rea 1 Transferrin endocytosis and recycling 1 P36543 460 3.40e-02 36 2 1 0.500 0.028 GO:0006826 BP 1 iron ion transport 1 P36543 460 3.52e-02 26 2 1 0.500 0.038 REAC:1222556 rea 1 ROS, RNS production in response to bacteria 1 P36543 460 3.54e-02 227 2 1 0.500 0.004 TF:M00465_0 tf 1 Factor: POU6F1; motif: GCATAAWTTAT; match class: 0 1 P36543 460 3.58e-02 230 2 1 0.500 0.004 TF:M07302_1 tf 1 Factor: NF-Y; motif: RGCCAATCRGN; match class: 1 1 O75391 460 3.77e-02 242 2 1 0.500 0.004 TF:M05961_1 tf 1 Factor: ZNF407; motif: CAACATGGA; match class: 1 1 O75391 460 3.77e-02 2471 2 2 1.000 0.001 TF:M04224_1 tf 1 Factor: NRL; motif: NNNNTGCTGAC; match class: 1 1 O75391,P36543 460 3.94e-02 253 2 1 0.500 0.004 TF:M01044_0 tf 1 Factor: Tbx5; motif: CTCACACCTT; match class: 0 1 O75391 460 4.04e-02 260 2 1 0.500 0.004 TF:M00251_0 tf 1 Factor: XBP-1; motif: NNGNTGACGTGKNNNWT; match class: 0 1 P36543 460 4.11e-02 264 2 1 0.500 0.004 TF:M00482_1 tf 1 Factor: Pitx2; motif: WNTAATCCCAR; match class: 1 1 O75391 460 4.15e-02 267 2 1 0.500 0.004 TF:M03988_0 tf 1 Factor: FLI1; motif: ACCGGAARTN; match class: 0 1 O75391 460 4.15e-02 267 2 1 0.500 0.004 TF:M03970_0 tf 1 Factor: ELK1; motif: ACCGGAAGTN; match class: 0 1 O75391 460 4.24e-02 240 2 1 0.500 0.004 MI:hsa-miR-25* mi 1 MI:hsa-miR-25* 1 P36543 460 4.33e-02 45 2 1 0.500 0.022 KEGG:05110 keg 1 Vibrio cholerae infection 1 P36543 460 4.46e-02 287 2 1 0.500 0.003 TF:M01797_1 tf 1 Factor: SIRT6; motif: AGATAARN; match class: 1 1 P36543 460 4.46e-02 2689 2 2 1.000 0.001 TF:M06190_1 tf 1 Factor: ZXDA; motif: NGGGGTC; match class: 1 1 O75391,P36543 460 4.46e-02 2689 2 2 1.000 0.001 TF:M06191_1 tf 1 Factor: ZXDB; motif: NGGGGTC; match class: 1 1 O75391,P36543 460 4.47e-02 288 2 1 0.500 0.003 TF:M01209_1 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 1 1 O75391 460 4.90e-02 51 2 1 0.500 0.020 KEGG:05323 keg 1 Rheumatoid arthritis 1 P36543 460 4.97e-02 320 2 1 0.500 0.003 TF:M06344_0 tf 1 Factor: ZNF530; motif: NGGGCAATWAYA; match class: 0 1 P36543 460 5.00e-02 53 2 1 0.500 0.019 GO:0015992 BP 1 proton transport 1 P36543 460 5.00e-02 52 2 1 0.500 0.019 KEGG:04721 keg 1 Synaptic vesicle cycle 1 P36543 461 5.12e-06 1272 8 7 0.875 0.006 GO:0044459 CC 1 plasma membrane part 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 8.73e-06 28 8 3 0.375 0.107 REAC:3928663 rea 1 EPHA-mediated growth cone collapse 1 P29317,P07947,P07948 461 1.35e-05 2420 8 8 1.000 0.003 GO:0005886 CC 1 plasma membrane 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 1.58e-05 2469 8 8 1.000 0.003 GO:0071944 CC 1 cell periphery 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 2.42e-05 39 8 3 0.375 0.077 REAC:3928665 rea 1 EPH-ephrin mediated repulsion of cells 1 P29317,P07947,P07948 461 4.62e-05 72 8 3 0.375 0.042 GO:0048013 BP 1 ephrin receptor signaling pathway 1 P29317,P07947,P07948 461 4.62e-05 72 8 3 0.375 0.042 GO:0031234 CC 1 extrinsic component of cytoplasmic side of plasma membrane 1 P19086,P07947,P07948 461 8.35e-05 11 8 2 0.250 0.182 GO:0031527 CC 1 filopodium membrane 1 O75781,P17677 461 1.03e-04 299 8 4 0.500 0.013 GO:0030155 BP 1 regulation of cell adhesion 1 Q9NWQ8,P29317,P07947,P07948 461 1.10e-04 304 8 4 0.500 0.013 GO:0031344 BP 1 regulation of cell projection organization 1 O75781,P29317,P17677,P07948 461 1.17e-04 98 8 3 0.375 0.031 GO:0019897 CC 1 extrinsic component of plasma membrane 1 P19086,P07947,P07948 461 1.56e-04 108 8 3 0.375 0.028 GO:0060491 BP 1 regulation of cell projection assembly 1 O75781,P29317,P17677 461 1.78e-04 11 8 2 0.250 0.182 REAC:210990 rea 1 PECAM1 interactions 1 P07947,P07948 461 1.78e-04 11 8 2 0.250 0.182 REAC:2029481 rea 1 FCGR activation 1 P07947,P07948 461 1.89e-04 115 8 3 0.375 0.026 GO:0004713 MF 1 protein tyrosine kinase activity 1 P29317,P07947,P07948 461 2.09e-04 119 8 3 0.375 0.025 GO:0009898 CC 1 cytoplasmic side of plasma membrane 1 P19086,P07947,P07948 461 2.09e-04 119 8 3 0.375 0.025 GO:0050863 BP 1 regulation of T cell activation 1 Q9NWQ8,P07947,P07948 461 2.29e-04 4 8 2 0.250 0.500 CORUM:2564 cor 1 p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated 1 P07947,P07948 461 2.31e-04 123 8 3 0.375 0.024 GO:1903037 BP 1 regulation of leukocyte cell-cell adhesion 1 Q9NWQ8,P07947,P07948 461 2.38e-04 83 8 3 0.375 0.036 REAC:2682334 rea 1 EPH-Ephrin signaling 1 P29317,P07947,P07948 461 2.52e-04 13 8 2 0.250 0.154 REAC:1433559 rea 1 Regulation of KIT signaling 1 P07947,P07948 461 2.78e-04 131 8 3 0.375 0.023 GO:0098562 CC 1 cytoplasmic side of membrane 1 P19086,P07947,P07948 461 3.83e-04 23 8 2 0.250 0.087 GO:0033628 BP 1 regulation of cell adhesion mediated by integrin 1 P29317,P07948 461 4.11e-04 2412 8 7 0.875 0.003 GO:0044425 CC 1 membrane part 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 4.36e-04 432 8 4 0.500 0.009 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 Q9NWQ8,P29317,P07947,P07948 461 4.39e-04 17 8 2 0.250 0.118 REAC:912631 rea 1 Regulation of signaling by CBL 1 P07947,P07948 461 4.42e-04 153 8 3 0.375 0.020 GO:0051249 BP 1 regulation of lymphocyte activation 1 Q9NWQ8,P07947,P07948 461 5.30e-04 27 8 2 0.250 0.074 GO:0051489 BP 1 regulation of filopodium assembly 1 O75781,P17677 461 5.51e-04 19 8 2 0.250 0.105 REAC:389513 rea 1 CTLA4 inhibitory signaling 1 P07947,P07948 461 5.73e-04 167 8 3 0.375 0.018 GO:0022407 BP 1 regulation of cell-cell adhesion 1 Q9NWQ8,P07947,P07948 461 6.25e-04 172 8 3 0.375 0.017 GO:0042110 BP 1 T cell activation 1 Q9NWQ8,P07947,P07948 461 6.25e-04 172 8 3 0.375 0.017 GO:0070489 BP 1 T cell aggregation 1 Q9NWQ8,P07947,P07948 461 6.36e-04 173 8 3 0.375 0.017 GO:0071593 BP 1 lymphocyte aggregation 1 Q9NWQ8,P07947,P07948 461 6.69e-04 176 8 3 0.375 0.017 GO:0019898 CC 1 extrinsic component of membrane 1 P19086,P07947,P07948 461 6.92e-04 178 8 3 0.375 0.017 GO:0070486 BP 1 leukocyte aggregation 1 Q9NWQ8,P07947,P07948 461 7.01e-04 31 8 2 0.250 0.065 GO:0033627 BP 1 cell adhesion mediated by integrin 1 P29317,P07948 461 7.04e-04 179 8 3 0.375 0.017 GO:0002694 BP 1 regulation of leukocyte activation 1 Q9NWQ8,P07947,P07948 461 7.96e-04 33 8 2 0.250 0.061 GO:0051250 BP 1 negative regulation of lymphocyte activation 1 Q9NWQ8,P07948 461 9.48e-04 198 8 3 0.375 0.015 GO:0007159 BP 1 leukocyte cell-cell adhesion 1 Q9NWQ8,P07947,P07948 461 9.48e-04 198 8 3 0.375 0.015 GO:0050865 BP 1 regulation of cell activation 1 Q9NWQ8,P07947,P07948 461 9.49e-04 36 8 2 0.250 0.056 GO:0004715 MF 1 non-membrane spanning protein tyrosine kinase activity 1 P07947,P07948 461 1.00e-03 37 8 2 0.250 0.054 GO:0038083 BP 1 peptidyl-tyrosine autophosphorylation 1 P07947,P07948 461 1.00e-03 37 8 2 0.250 0.054 GO:0046847 BP 1 filopodium assembly 1 O75781,P17677 461 1.00e-03 37 8 2 0.250 0.054 GO:0002695 BP 1 negative regulation of leukocyte activation 1 Q9NWQ8,P07948 461 1.11e-03 39 8 2 0.250 0.051 GO:0031295 BP 1 T cell costimulation 1 P07947,P07948 461 1.11e-03 39 8 2 0.250 0.051 GO:0031294 BP 1 lymphocyte costimulation 1 P07947,P07948 461 1.21e-03 215 8 3 0.375 0.014 GO:0098552 CC 1 side of membrane 1 P19086,P07947,P07948 461 1.21e-03 28 8 2 0.250 0.071 REAC:389356 rea 1 CD28 co-stimulation 1 P07947,P07948 461 1.22e-03 216 8 3 0.375 0.014 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 Q9NWQ8,P07947,P07948 461 1.48e-03 593 8 4 0.500 0.007 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 Q9NWQ8,P29317,P07947,P07948 461 1.49e-03 45 8 2 0.250 0.044 GO:0030175 CC 1 filopodium 1 O75781,P17677 461 1.57e-03 235 8 3 0.375 0.013 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 Q9NWQ8,P07947,P07948 461 1.63e-03 238 8 3 0.375 0.013 GO:0046649 BP 1 lymphocyte activation 1 Q9NWQ8,P07947,P07948 461 1.63e-03 238 8 3 0.375 0.013 GO:0030031 BP 1 cell projection assembly 1 O75781,P29317,P17677 461 1.69e-03 48 8 2 0.250 0.042 GO:0050866 BP 1 negative regulation of cell activation 1 Q9NWQ8,P07948 461 1.81e-03 3004 8 7 0.875 0.002 GO:0007165 BP 1 signal transduction 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 2.11e-03 650 8 4 0.500 0.006 GO:0030030 BP 1 cell projection organization 1 O75781,P29317,P17677,P07948 461 2.30e-03 56 8 2 0.250 0.036 GO:0046058 BP 1 cAMP metabolic process 1 O75781,P29317 461 2.31e-03 4600 8 8 1.000 0.002 GO:0016020 CC 1 membrane 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 2.36e-03 39 8 2 0.250 0.051 REAC:3928662 rea 1 EPHB-mediated forward signaling 1 P07947,P07948 461 2.48e-03 678 8 4 0.500 0.006 GO:0007155 BP 1 cell adhesion 1 Q9NWQ8,P29317,P07947,P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0002774 BP 1 Fc receptor mediated inhibitory signaling pathway 1 P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0070662 BP 1 mast cell proliferation 1 P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0070668 BP 1 positive regulation of mast cell proliferation 1 P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0070309 BP 1 lens fiber cell morphogenesis 1 P29317 461 2.51e-03 1 8 1 0.125 1.000 GO:0070667 BP 1 negative regulation of mast cell proliferation 1 P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0070666 BP 1 regulation of mast cell proliferation 1 P07948 461 2.51e-03 1 8 1 0.125 1.000 GO:0060444 BP 1 branching involved in mammary gland duct morphogenesis 1 P29317 461 2.56e-03 684 8 4 0.500 0.006 GO:0022610 BP 1 biological adhesion 1 Q9NWQ8,P29317,P07947,P07948 461 2.76e-03 285 8 3 0.375 0.011 GO:0045321 BP 1 leukocyte activation 1 Q9NWQ8,P07947,P07948 461 2.78e-03 459 8 4 0.500 0.009 REAC:422475 rea 1 Axon guidance 1 P29317,P17677,P07947,P07948 461 3.13e-03 721 8 4 0.500 0.006 GO:0004871 MF 1 signal transducer activity 1 Q9NWQ8,P19086,P29317,P07948 461 3.14e-03 3262 8 7 0.875 0.002 GO:0007154 BP 1 cell communication 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 3.18e-03 3268 8 7 0.875 0.002 GO:0044700 BP 1 single organism signaling 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 3.22e-03 3274 8 7 0.875 0.002 GO:0023052 BP 1 signaling 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 3.29e-03 67 8 2 0.250 0.030 GO:0044325 MF 1 ion channel binding 1 P07947,P07948 461 3.30e-03 303 8 3 0.375 0.010 GO:0002757 BP 1 immune response-activating signal transduction 1 Q9NWQ8,P07947,P07948 461 3.30e-03 731 8 4 0.500 0.005 GO:0005102 MF 1 receptor binding 1 Q9NWQ8,P19086,P07947,P07948 461 3.39e-03 68 8 2 0.250 0.029 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 P07947,P07948 461 3.39e-03 68 8 2 0.250 0.029 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 P07947,P07948 461 3.39e-03 68 8 2 0.250 0.029 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 P07947,P07948 461 3.59e-03 70 8 2 0.250 0.029 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 P07947,P07948 461 3.94e-03 322 8 3 0.375 0.009 GO:0002764 BP 1 immune response-regulating signaling pathway 1 Q9NWQ8,P07947,P07948 461 4.12e-03 75 8 2 0.250 0.027 GO:0098858 CC 1 actin-based cell projection 1 O75781,P17677 461 4.12e-03 75 8 2 0.250 0.027 GO:0009187 BP 1 cyclic nucleotide metabolic process 1 O75781,P29317 461 4.34e-03 333 8 3 0.375 0.009 GO:0005924 CC 1 cell-substrate adherens junction 1 P62070,P29317,P07947 461 4.34e-03 333 8 3 0.375 0.009 GO:0005925 CC 1 focal adhesion 1 P62070,P29317,P07947 461 4.36e-03 53 8 2 0.250 0.038 REAC:388841 rea 1 Costimulation by the CD28 family 1 P07947,P07948 461 4.38e-03 334 8 3 0.375 0.009 GO:0016337 BP 1 single organismal cell-cell adhesion 1 Q9NWQ8,P07947,P07948 461 4.49e-03 337 8 3 0.375 0.009 GO:0030055 CC 1 cell-substrate junction 1 P62070,P29317,P07947 461 4.49e-03 337 8 3 0.375 0.009 GO:0002253 BP 1 activation of immune response 1 Q9NWQ8,P07947,P07948 461 5.02e-03 2 8 1 0.125 0.500 GO:0002513 BP 1 tolerance induction to self antigen 1 P07948 461 5.02e-03 2 8 1 0.125 0.500 GO:0060160 BP 1 negative regulation of dopamine receptor signaling pathway 1 O75781 461 5.02e-03 2 8 1 0.125 0.500 GO:0034136 BP 1 negative regulation of toll-like receptor 2 signaling pathway 1 P07948 461 5.02e-03 2 8 1 0.125 0.500 GO:0002765 BP 1 immune response-inhibiting signal transduction 1 P07948 461 5.02e-03 2 8 1 0.125 0.500 GO:0002767 BP 1 immune response-inhibiting cell surface receptor signaling pathway 1 P07948 461 5.31e-03 357 8 3 0.375 0.008 GO:0007186 BP 1 G-protein coupled receptor signaling pathway 1 O75781,P19086,P17677 461 5.73e-03 1524 8 5 0.625 0.003 GO:0030154 BP 1 cell differentiation 1 P62070,P29317,P17677,P07947,P07948 461 5.89e-03 370 8 3 0.375 0.008 GO:0098602 BP 1 single organism cell adhesion 1 Q9NWQ8,P07947,P07948 461 6.32e-03 93 8 2 0.250 0.022 GO:0050870 BP 1 positive regulation of T cell activation 1 P07947,P07948 461 6.59e-03 95 8 2 0.250 0.021 GO:1903039 BP 1 positive regulation of leukocyte cell-cell adhesion 1 P07947,P07948 461 6.60e-03 385 8 3 0.375 0.008 GO:0001775 BP 1 cell activation 1 Q9NWQ8,P07947,P07948 461 6.70e-03 387 8 3 0.375 0.008 GO:0050778 BP 1 positive regulation of immune response 1 Q9NWQ8,P07947,P07948 461 6.71e-03 2 8 1 0.125 0.500 REAC:5690714 rea 1 CD22 mediated BCR regulation 1 P07948 461 6.73e-03 96 8 2 0.250 0.021 GO:0005057 MF 1 signal transducer activity, downstream of receptor 1 P19086,P07948 461 6.80e-03 389 8 3 0.375 0.008 GO:0098609 BP 1 cell-cell adhesion 1 Q9NWQ8,P07947,P07948 461 6.99e-03 5806 8 8 1.000 0.001 HPA:040010 hpa 1 soft tissue 2; adipocytes 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 7.01e-03 98 8 2 0.250 0.020 GO:0001649 BP 1 osteoblast differentiation 1 P62070,P29317 461 7.44e-03 101 8 2 0.250 0.020 GO:0060326 BP 1 cell chemotaxis 1 P29317,P07948 461 7.53e-03 3 8 1 0.125 0.333 GO:0070307 BP 1 lens fiber cell development 1 P29317 461 7.53e-03 3 8 1 0.125 0.333 GO:2000670 BP 1 positive regulation of dendritic cell apoptotic process 1 P07948 461 7.53e-03 3 8 1 0.125 0.333 GO:0060603 BP 1 mammary gland duct morphogenesis 1 P29317 461 7.56e-03 70 8 2 0.250 0.029 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 P07947,P07948 461 8.00e-03 3755 8 7 0.875 0.002 GO:0051716 BP 1 cellular response to stimulus 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 8.25e-03 1649 8 5 0.625 0.003 GO:0048869 BP 1 cellular developmental process 1 P62070,P29317,P17677,P07947,P07948 461 8.33e-03 107 8 2 0.250 0.019 GO:0031253 CC 1 cell projection membrane 1 O75781,P17677 461 8.64e-03 109 8 2 0.250 0.018 GO:0022409 BP 1 positive regulation of cell-cell adhesion 1 P07947,P07948 461 9.60e-03 115 8 2 0.250 0.017 GO:0051251 BP 1 positive regulation of lymphocyte activation 1 P07947,P07948 461 1.00e-02 4 8 1 0.125 0.250 GO:0002089 BP 1 lens morphogenesis in camera-type eye 1 P29317 461 1.00e-02 4 8 1 0.125 0.250 GO:0030889 BP 1 negative regulation of B cell proliferation 1 P07948 461 1.00e-02 4 8 1 0.125 0.250 GO:0070306 BP 1 lens fiber cell differentiation 1 P29317 461 1.00e-02 4 8 1 0.125 0.250 GO:2000668 BP 1 regulation of dendritic cell apoptotic process 1 P07948 461 1.00e-02 4 8 1 0.125 0.250 GO:0034144 BP 1 negative regulation of toll-like receptor 4 signaling pathway 1 P07948 461 1.00e-02 4 8 1 0.125 0.250 GO:0097048 BP 1 dendritic cell apoptotic process 1 P07948 461 1.01e-02 81 8 2 0.250 0.025 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 P07947,P07948 461 1.01e-02 5533 8 8 1.000 0.001 GO:0050794 BP 1 regulation of cellular process 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 1.08e-02 122 8 2 0.250 0.016 GO:0070372 BP 1 regulation of ERK1 and ERK2 cascade 1 P29317,P07948 461 1.10e-02 123 8 2 0.250 0.016 GO:0045121 CC 1 membrane raft 1 Q9NWQ8,P07948 461 1.11e-02 124 8 2 0.250 0.016 GO:0098857 CC 1 membrane microdomain 1 Q9NWQ8,P07948 461 1.14e-02 1016 8 4 0.500 0.004 GO:0006928 BP 1 movement of cell or subcellular component 1 O75781,P29317,P07947,P07948 461 1.17e-02 127 8 2 0.250 0.016 GO:0002696 BP 1 positive regulation of leukocyte activation 1 P07947,P07948 461 1.18e-02 472 8 3 0.375 0.006 GO:0004672 MF 1 protein kinase activity 1 P29317,P07947,P07948 461 1.20e-02 129 8 2 0.250 0.016 GO:0070371 BP 1 ERK1 and ERK2 cascade 1 P29317,P07948 461 1.25e-02 5 8 1 0.125 0.200 GO:0004716 MF 1 signal transducer, downstream of receptor, with protein tyrosine kinase activity 1 P07948 461 1.25e-02 5 8 1 0.125 0.200 GO:0050855 BP 1 regulation of B cell receptor signaling pathway 1 P07948 461 1.25e-02 5 8 1 0.125 0.200 GO:0031821 MF 1 G-protein coupled serotonin receptor binding 1 P19086 461 1.25e-02 5 8 1 0.125 0.200 GO:0060443 BP 1 mammary gland morphogenesis 1 P29317 461 1.25e-02 5 8 1 0.125 0.200 GO:0034135 BP 1 regulation of toll-like receptor 2 signaling pathway 1 P07948 461 1.26e-02 132 8 2 0.250 0.015 GO:0050867 BP 1 positive regulation of cell activation 1 P07947,P07948 461 1.26e-02 132 8 2 0.250 0.015 GO:0030099 BP 1 myeloid cell differentiation 1 P29317,P07948 461 1.28e-02 133 8 2 0.250 0.015 GO:0002683 BP 1 negative regulation of immune system process 1 Q9NWQ8,P07948 461 1.39e-02 499 8 3 0.375 0.006 GO:0002684 BP 1 positive regulation of immune system process 1 Q9NWQ8,P07947,P07948 461 1.40e-02 501 8 3 0.375 0.006 GO:0050776 BP 1 regulation of immune response 1 Q9NWQ8,P07947,P07948 461 1.43e-02 504 8 3 0.375 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 O75781,P29317,P17677 461 1.43e-02 141 8 2 0.250 0.014 GO:0018108 BP 1 peptidyl-tyrosine phosphorylation 1 P07947,P07948 461 1.45e-02 142 8 2 0.250 0.014 GO:0006909 BP 1 phagocytosis 1 P07947,P07948 461 1.47e-02 143 8 2 0.250 0.014 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 Q9NWQ8,P07948 461 1.47e-02 143 8 2 0.250 0.014 GO:0018212 BP 1 peptidyl-tyrosine modification 1 P07947,P07948 461 1.48e-02 718 8 4 0.500 0.006 REAC:1266738 rea 1 Developmental Biology 1 P29317,P17677,P07947,P07948 461 1.50e-02 6 8 1 0.125 0.167 GO:0001782 BP 1 B cell homeostasis 1 P07948 461 1.50e-02 6 8 1 0.125 0.167 GO:0005068 MF 1 transmembrane receptor protein tyrosine kinase adaptor activity 1 Q9NWQ8 461 1.56e-02 5839 8 8 1.000 0.001 GO:0050789 BP 1 regulation of biological process 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 1.58e-02 148 8 2 0.250 0.014 GO:0031346 BP 1 positive regulation of cell projection organization 1 O75781,P07948 461 1.62e-02 150 8 2 0.250 0.013 GO:0001503 BP 1 ossification 1 P62070,P29317 461 1.72e-02 155 8 2 0.250 0.013 GO:0098589 CC 1 membrane region 1 Q9NWQ8,P07948 461 1.75e-02 7 8 1 0.125 0.143 GO:0002507 BP 1 tolerance induction 1 P07948 461 1.79e-02 158 8 2 0.250 0.013 GO:0003924 MF 1 GTPase activity 1 P19086,P62070 461 1.88e-02 1165 8 4 0.500 0.003 GO:0002376 BP 1 immune system process 1 Q9NWQ8,P29317,P07947,P07948 461 1.93e-02 164 8 2 0.250 0.012 GO:0002521 BP 1 leukocyte differentiation 1 P29317,P07948 461 1.95e-02 165 8 2 0.250 0.012 GO:0038093 BP 1 Fc receptor signaling pathway 1 P07947,P07948 461 1.97e-02 166 8 2 0.250 0.012 GO:0050900 BP 1 leukocyte migration 1 P07947,P07948 461 2.00e-02 8 8 1 0.125 0.125 GO:0033598 BP 1 mammary gland epithelial cell proliferation 1 P29317 461 2.00e-02 8 8 1 0.125 0.125 GO:0060159 BP 1 regulation of dopamine receptor signaling pathway 1 O75781 461 2.02e-02 168 8 2 0.250 0.012 GO:0045785 BP 1 positive regulation of cell adhesion 1 P07947,P07948 461 2.10e-02 578 8 3 0.375 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P29317,P07947,P07948 461 2.12e-02 4356 8 7 0.875 0.002 GO:0050896 BP 1 response to stimulus 1 Q9NWQ8,O75781,P19086,P29317,P17677,P07947,P07948 461 2.14e-02 582 8 3 0.375 0.005 GO:0005912 CC 1 adherens junction 1 P62070,P29317,P07947 461 2.19e-02 3675 8 6 0.750 0.002 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 Q9NWQ8,O75781,P19086,P62070,P17677,P07947 461 2.24e-02 591 8 3 0.375 0.005 GO:0070161 CC 1 anchoring junction 1 P62070,P29317,P07947 461 2.25e-02 9 8 1 0.125 0.111 GO:0050869 BP 1 negative regulation of B cell activation 1 P07948 461 2.25e-02 9 8 1 0.125 0.111 GO:0034134 BP 1 toll-like receptor 2 signaling pathway 1 P07948 461 2.25e-02 9 8 1 0.125 0.111 GO:0031683 MF 1 G-protein beta/gamma-subunit complex binding 1 P19086 461 2.28e-02 179 8 2 0.250 0.011 GO:0046777 BP 1 protein autophosphorylation 1 P07947,P07948 461 2.34e-02 7 8 1 0.125 0.143 REAC:5621480 rea 1 Dectin-2 family 1 P07948 461 2.34e-02 7 8 1 0.125 0.143 REAC:75892 rea 1 Platelet Adhesion to exposed collagen 1 P07948 461 2.48e-02 2101 8 5 0.625 0.002 GO:0048583 BP 1 regulation of response to stimulus 1 Q9NWQ8,O75781,P29317,P07947,P07948 461 2.50e-02 10 8 1 0.125 0.100 GO:0007194 BP 1 negative regulation of adenylate cyclase activity 1 O75781 461 2.50e-02 10 8 1 0.125 0.100 GO:0002902 BP 1 regulation of B cell apoptotic process 1 P07948 461 2.50e-02 10 8 1 0.125 0.100 GO:0031280 BP 1 negative regulation of cyclase activity 1 O75781 461 2.51e-02 2 8 1 0.125 0.500 CORUM:2910 cor 1 PLC-gamma-2-Lyn-FcR-gamma complex 1 P07948 461 2.66e-02 6242 8 8 1.000 0.001 GO:0065007 BP 1 biological regulation 1 Q9NWQ8,O75781,P19086,P62070,P29317,P17677,P07947,P07948 461 2.67e-02 630 8 3 0.375 0.005 GO:0016301 MF 1 kinase activity 1 P29317,P07947,P07948 461 2.75e-02 11 8 1 0.125 0.091 GO:0090330 BP 1 regulation of platelet aggregation 1 P07948 461 2.75e-02 11 8 1 0.125 0.091 GO:0002088 BP 1 lens development in camera-type eye 1 P29317 461 2.75e-02 11 8 1 0.125 0.091 GO:0001783 BP 1 B cell apoptotic process 1 P07948 461 2.75e-02 11 8 1 0.125 0.091 GO:0060397 BP 1 JAK-STAT cascade involved in growth hormone signaling pathway 1 P07948 461 2.76e-02 637 8 3 0.375 0.005 GO:0009968 BP 1 negative regulation of signal transduction 1 O75781,P29317,P07948 461 2.79e-02 640 8 3 0.375 0.005 GO:0016477 BP 1 cell migration 1 P29317,P07947,P07948 461 2.81e-02 380 8 2 0.250 0.005 MI:hsa-miR-185 mi 1 MI:hsa-miR-185 1 P62070,P17677 461 3.00e-02 12 8 1 0.125 0.083 GO:0007205 BP 1 protein kinase C-activating G-protein coupled receptor signaling pathway 1 P17677 461 3.00e-02 12 8 1 0.125 0.083 GO:0034143 BP 1 regulation of toll-like receptor 4 signaling pathway 1 P07948 461 3.00e-02 12 8 1 0.125 0.083 GO:0090025 BP 1 regulation of monocyte chemotaxis 1 P07948 461 3.00e-02 12 8 1 0.125 0.083 GO:0051350 BP 1 negative regulation of lyase activity 1 O75781 461 3.02e-02 6 8 1 0.125 0.167 HP:0010922 hp 1 Membranous cataract 1 P29317 461 3.03e-02 5272 8 7 0.875 0.001 HPA:040040 hpa 1 soft tissue 2; peripheral nerve 1 Q9NWQ8,O75781,P19086,P62070,P17677,P07947,P07948 461 3.06e-02 661 8 3 0.375 0.005 GO:0010648 BP 1 negative regulation of cell communication 1 O75781,P29317,P07948 461 3.10e-02 3931 8 6 0.750 0.002 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 Q9NWQ8,O75781,P19086,P62070,P29317,P07947 461 3.11e-02 665 8 3 0.375 0.005 GO:0023057 BP 1 negative regulation of signaling 1 O75781,P29317,P07948 461 3.20e-02 408 8 2 0.250 0.005 MI:hsa-miR-570 mi 1 MI:hsa-miR-570 1 P62070,P17677 461 3.25e-02 13 8 1 0.125 0.077 GO:0043114 BP 1 regulation of vascular permeability 1 P07947 461 3.25e-02 13 8 1 0.125 0.077 GO:2000108 BP 1 positive regulation of leukocyte apoptotic process 1 P07948 461 3.25e-02 13 8 1 0.125 0.077 GO:0002260 BP 1 lymphocyte homeostasis 1 P07948 461 3.44e-02 690 8 3 0.375 0.004 GO:0002682 BP 1 regulation of immune system process 1 Q9NWQ8,P07947,P07948 461 3.50e-02 14 8 1 0.125 0.071 GO:0030818 BP 1 negative regulation of cAMP biosynthetic process 1 O75781 461 3.50e-02 14 8 1 0.125 0.071 GO:0030803 BP 1 negative regulation of cyclic nucleotide biosynthetic process 1 O75781 461 3.68e-02 707 8 3 0.375 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 O75781,P29317,P07948 461 3.74e-02 711 8 3 0.375 0.004 GO:0051674 BP 1 localization of cell 1 P29317,P07947,P07948 461 3.74e-02 711 8 3 0.375 0.004 GO:0048870 BP 1 cell motility 1 P29317,P07947,P07948 461 3.75e-02 15 8 1 0.125 0.067 GO:0005834 CC 1 heterotrimeric G-protein complex 1 P19086 461 3.75e-02 15 8 1 0.125 0.067 GO:0022612 BP 1 gland morphogenesis 1 P29317 461 3.75e-02 15 8 1 0.125 0.067 GO:0032945 BP 1 negative regulation of mononuclear cell proliferation 1 P07948 461 3.75e-02 15 8 1 0.125 0.067 GO:0051491 BP 1 positive regulation of filopodium assembly 1 O75781 461 3.75e-02 15 8 1 0.125 0.067 GO:0050672 BP 1 negative regulation of lymphocyte proliferation 1 P07948 461 3.75e-02 15 8 1 0.125 0.067 GO:0034110 BP 1 regulation of homotypic cell-cell adhesion 1 P07948 461 3.75e-02 15 8 1 0.125 0.067 GO:1905360 CC 1 GTPase complex 1 P19086 461 3.75e-02 15 8 1 0.125 0.067 GO:0097028 BP 1 dendritic cell differentiation 1 P07948 461 3.76e-02 3 8 1 0.125 0.333 CORUM:2565 cor 1 CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line) 1 P07948 461 3.76e-02 3 8 1 0.125 0.333 CORUM:5190 cor 1 TIAM1-EFNB1-EPHA2 complex 1 P29317 461 3.81e-02 1416 8 4 0.500 0.003 GO:0007166 BP 1 cell surface receptor signaling pathway 1 Q9NWQ8,P29317,P07947,P07948 461 3.99e-02 728 8 3 0.375 0.004 GO:0042995 CC 1 cell projection 1 O75781,P29317,P17677 461 4.00e-02 16 8 1 0.125 0.062 GO:0034122 BP 1 negative regulation of toll-like receptor signaling pathway 1 P07948 461 4.00e-02 16 8 1 0.125 0.062 GO:0071378 BP 1 cellular response to growth hormone stimulus 1 P07948 461 4.00e-02 16 8 1 0.125 0.062 GO:0060396 BP 1 growth hormone receptor signaling pathway 1 P07948 461 4.00e-02 16 8 1 0.125 0.062 GO:0030800 BP 1 negative regulation of cyclic nucleotide metabolic process 1 O75781 461 4.00e-02 16 8 1 0.125 0.062 GO:0030815 BP 1 negative regulation of cAMP metabolic process 1 O75781 461 4.00e-02 16 8 1 0.125 0.062 GO:0071675 BP 1 regulation of mononuclear cell migration 1 P07948 461 4.01e-02 8 8 1 0.125 0.125 HP:0010700 hp 1 Total cataract 1 P29317 461 4.02e-02 1438 8 4 0.500 0.003 GO:0051128 BP 1 regulation of cellular component organization 1 O75781,P29317,P17677,P07948 461 4.16e-02 739 8 3 0.375 0.004 GO:0006955 BP 1 immune response 1 Q9NWQ8,P07947,P07948 461 4.22e-02 246 8 2 0.250 0.008 GO:0006935 BP 1 chemotaxis 1 P29317,P07948 461 4.22e-02 246 8 2 0.250 0.008 GO:0042330 BP 1 taxis 1 P29317,P07948 461 4.25e-02 17 8 1 0.125 0.059 GO:0033006 BP 1 regulation of mast cell activation involved in immune response 1 P07948 461 4.25e-02 17 8 1 0.125 0.059 GO:0043304 BP 1 regulation of mast cell degranulation 1 P07948 461 4.25e-02 17 8 1 0.125 0.059 GO:1900372 BP 1 negative regulation of purine nucleotide biosynthetic process 1 O75781 461 4.25e-02 17 8 1 0.125 0.059 GO:0010591 BP 1 regulation of lamellipodium assembly 1 P29317 461 4.25e-02 17 8 1 0.125 0.059 GO:0030809 BP 1 negative regulation of nucleotide biosynthetic process 1 O75781 461 4.25e-02 17 8 1 0.125 0.059 GO:0042169 MF 1 SH2 domain binding 1 Q9NWQ8 461 4.25e-02 17 8 1 0.125 0.059 GO:0070664 BP 1 negative regulation of leukocyte proliferation 1 P07948 461 4.27e-02 746 8 3 0.375 0.004 GO:0030054 CC 1 cell junction 1 P62070,P29317,P07947 461 4.42e-02 755 8 3 0.375 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P29317,P07947,P07948 461 4.50e-02 18 8 1 0.125 0.056 GO:0060416 BP 1 response to growth hormone 1 P07948 461 4.50e-02 18 8 1 0.125 0.056 GO:0050854 BP 1 regulation of antigen receptor-mediated signaling pathway 1 P07948 461 4.50e-02 18 8 1 0.125 0.056 GO:0030888 BP 1 regulation of B cell proliferation 1 P07948 461 4.50e-02 18 8 1 0.125 0.056 GO:0061180 BP 1 mammary gland epithelium development 1 P29317 461 4.74e-02 775 8 3 0.375 0.004 GO:0048585 BP 1 negative regulation of response to stimulus 1 O75781,P29317,P07948 461 4.74e-02 19 8 1 0.125 0.053 GO:0001776 BP 1 leukocyte homeostasis 1 P07948 461 4.74e-02 19 8 1 0.125 0.053 GO:0045744 BP 1 negative regulation of G-protein coupled receptor protein signaling pathway 1 O75781 461 4.74e-02 19 8 1 0.125 0.053 GO:0033003 BP 1 regulation of mast cell activation 1 P07948 461 4.74e-02 19 8 1 0.125 0.053 GO:0042531 BP 1 positive regulation of tyrosine phosphorylation of STAT protein 1 P07948 461 4.79e-02 263 8 2 0.250 0.008 GO:0030097 BP 1 hemopoiesis 1 P29317,P07948 461 4.93e-02 497 8 2 0.250 0.004 HPA:007040_03 hpa 1 cerebral cortex; neuropil[Uncertain,High] 1 P19086,P17677 461 4.99e-02 20 8 1 0.125 0.050 GO:0002548 BP 1 monocyte chemotaxis 1 P07948 461 4.99e-02 20 8 1 0.125 0.050 GO:0010543 BP 1 regulation of platelet activation 1 P07948 461 4.99e-02 20 8 1 0.125 0.050 GO:0002886 BP 1 regulation of myeloid leukocyte mediated immunity 1 P07948 461 4.99e-02 20 8 1 0.125 0.050 GO:0034142 BP 1 toll-like receptor 4 signaling pathway 1 P07948 461 4.99e-02 20 8 1 0.125 0.050 GO:0031663 BP 1 lipopolysaccharide-mediated signaling pathway 1 P07948 461 4.99e-02 20 8 1 0.125 0.050 GO:0046849 BP 1 bone remodeling 1 P29317 461 5.00e-02 15 8 1 0.125 0.067 REAC:202427 rea 1 Phosphorylation of CD3 and TCR zeta chains 1 Q9NWQ8 461 5.00e-02 51 8 2 0.250 0.039 KEGG:04730 keg 1 Long-term depression 1 P19086,P07948 461 5.00e-02 4 8 1 0.125 0.250 CORUM:2536 cor 1 PLC-gamma-2-SLP-76-Lyn-Grb2 complex 1 P07948 461 5.00e-02 790 8 3 0.375 0.004 GO:0048468 BP 1 cell development 1 P29317,P17677,P07948 461 5.00e-02 1338 8 5 0.625 0.004 TF:M07054_1 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 1 O75781,P19086,P62070,P29317,P07948 461 5.00e-02 1 8 1 0.125 1.000 OMIM:116600 omi 1 CATARACT 6, MULTIPLE TYPES; CTRCT6;;CATARACT, POSTERIOR POLAR, 1; CTPP1;;CATARACT, AGE-RELATED CORTICAL, 2; ARCC2 1 P29317 461 5.00e-02 10 8 1 0.125 0.100 HP:0001134 hp 1 Anterior polar cataract 1 P29317 461 5.00e-02 4 8 1 0.125 0.250 CORUM:2563 cor 1 FGFR2-c-Cbl-Lyn-Fyn complex 1 P07948 462 3.56e-04 44 3 2 0.667 0.045 GO:0010501 BP 1 RNA secondary structure unwinding 1 Q9UHL0,Q9NUU7 462 7.83e-04 65 3 2 0.667 0.031 GO:0004004 MF 1 ATP-dependent RNA helicase activity 1 Q9UHL0,Q9NUU7 462 8.07e-04 66 3 2 0.667 0.030 GO:0008186 MF 1 RNA-dependent ATPase activity 1 Q9UHL0,Q9NUU7 462 8.07e-04 66 3 2 0.667 0.030 GO:0003724 MF 1 RNA helicase activity 1 Q9UHL0,Q9NUU7 462 1.01e-03 1276 3 3 1.000 0.002 TF:M00136_0 tf 1 Factor: Oct-1; motif: NNGAATATKCANNNN; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 1.44e-03 88 3 2 0.667 0.023 GO:0008026 MF 1 ATP-dependent helicase activity 1 Q9UHL0,Q9NUU7 462 1.44e-03 88 3 2 0.667 0.023 GO:0070035 MF 1 purine NTP-dependent helicase activity 1 Q9UHL0,Q9NUU7 462 1.65e-03 7 3 1 0.333 0.143 TF:M03964_1 tf 1 Factor: EBF1; motif: ANTCCCNWGGGAMT; match class: 1 1 Q9UHL0 462 1.86e-03 100 3 2 0.667 0.020 GO:0006406 BP 1 mRNA export from nucleus 1 Q9UHL0,Q9NUU7 462 1.86e-03 100 3 2 0.667 0.020 GO:0071427 BP 1 mRNA-containing ribonucleoprotein complex export from nucleus 1 Q9UHL0,Q9NUU7 462 2.01e-03 104 3 2 0.667 0.019 GO:0051028 BP 1 mRNA transport 1 Q9UHL0,Q9NUU7 462 2.29e-03 111 3 2 0.667 0.018 GO:0006405 BP 1 RNA export from nucleus 1 Q9UHL0,Q9NUU7 462 2.33e-03 112 3 2 0.667 0.018 GO:0071426 BP 1 ribonucleoprotein complex export from nucleus 1 Q9UHL0,Q9NUU7 462 2.33e-03 112 3 2 0.667 0.018 GO:0004386 MF 1 helicase activity 1 Q9UHL0,Q9NUU7 462 2.46e-03 115 3 2 0.667 0.017 GO:0071166 BP 1 ribonucleoprotein complex localization 1 Q9UHL0,Q9NUU7 462 2.83e-03 12 3 1 0.333 0.083 TF:M05406_0 tf 1 Factor: ZNF781; motif: TGGGATWTGGTT; match class: 0 1 Q15121 462 2.91e-03 125 3 2 0.667 0.016 GO:0050657 BP 1 nucleic acid transport 1 Q9UHL0,Q9NUU7 462 2.91e-03 125 3 2 0.667 0.016 GO:0050658 BP 1 RNA transport 1 Q9UHL0,Q9NUU7 462 3.05e-03 128 3 2 0.667 0.016 GO:0051236 BP 1 establishment of RNA localization 1 Q9UHL0,Q9NUU7 462 3.75e-03 142 3 2 0.667 0.014 GO:0015931 BP 1 nucleobase-containing compound transport 1 Q9UHL0,Q9NUU7 462 3.77e-03 16 3 1 0.333 0.062 TF:M07427_1 tf 1 Factor: NURR1; motif: AAAGGTCANN; match class: 1 1 Q15121 462 4.35e-03 153 3 2 0.667 0.013 GO:0051168 BP 1 nuclear export 1 Q9UHL0,Q9NUU7 462 4.64e-03 158 3 2 0.667 0.013 GO:0006403 BP 1 RNA localization 1 Q9UHL0,Q9NUU7 462 7.29e-03 31 3 1 0.333 0.032 TF:M03964_0 tf 1 Factor: EBF1; motif: ANTCCCNWGGGAMT; match class: 0 1 Q9UHL0 462 7.29e-03 31 3 1 0.333 0.032 TF:M00767_0 tf 1 Factor: FXR; motif: GGGTBAATRACCY; match class: 0 1 Q9UHL0 462 7.46e-03 18 3 1 0.333 0.056 REAC:112409 rea 1 RAF-independent MAPK1/3 activation 1 Q15121 462 7.52e-03 32 3 1 0.333 0.031 TF:M05971_0 tf 1 Factor: ZNF860; motif: NTGGMCGAAAGA; match class: 0 1 Q9UHL0 462 1.01e-02 43 3 1 0.333 0.023 TF:M05637_0 tf 1 Factor: ZNF189; motif: KGTTGSGGGATY; match class: 0 1 Q15121 462 1.01e-02 43 3 1 0.333 0.023 TF:M05847_1 tf 1 Factor: ZNF837; motif: NCCWMAWAAARM; match class: 1 1 Q9UHL0 462 1.06e-02 45 3 1 0.333 0.022 TF:M05672_0 tf 1 Factor: ZNF133; motif: NARTGAAAAAGA; match class: 0 1 Q9NUU7 462 1.29e-02 264 3 2 0.667 0.008 GO:0042623 MF 1 ATPase activity, coupled 1 Q9UHL0,Q9NUU7 462 1.31e-02 6 3 1 0.333 0.167 GO:0046325 BP 1 negative regulation of glucose import 1 Q15121 462 1.34e-02 57 3 1 0.333 0.018 TF:M00631_0 tf 1 Factor: FXR:RXR-alpha; motif: CAAGGTSAWTAACC; match class: 0 1 Q9UHL0 462 1.39e-02 889 3 2 0.667 0.002 TF:M04044_0 tf 1 Factor: MYBL1; motif: NNAACCGTTAA; match class: 0 1 Q9UHL0,Q9NUU7 462 1.42e-02 1377 3 3 1.000 0.002 GO:0071702 BP 1 organic substance transport 1 Q9UHL0,Q15121,Q9NUU7 462 1.45e-02 62 3 1 0.333 0.016 TF:M04055_1 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 1 1 Q15121 462 1.45e-02 62 3 1 0.333 0.016 TF:M04055_0 tf 1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 0 1 Q15121 462 1.48e-02 63 3 1 0.333 0.016 TF:M06647_0 tf 1 Factor: ZNF665; motif: NGGKCTTKATGA; match class: 0 1 Q15121 462 1.62e-02 959 3 2 0.667 0.002 TF:M01817_1 tf 1 Factor: TEF-1; motif: GWGGAATGT; match class: 1 1 Q9UHL0,Q15121 462 1.74e-02 8 3 1 0.333 0.125 GO:0010829 BP 1 negative regulation of glucose transport 1 Q15121 462 1.74e-02 8 3 1 0.333 0.125 GO:0033391 CC 1 chromatoid body 1 Q9UHL0 462 1.76e-02 75 3 1 0.333 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 Q15121 462 1.82e-02 3348 3 3 1.000 0.001 TF:M01252_0 tf 1 Factor: E2F-6; motif: CNTTTCNT; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 1.83e-02 78 3 1 0.333 0.013 TF:M02073_1 tf 1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 1 Q9NUU7 462 1.87e-02 318 3 2 0.667 0.006 GO:0006913 BP 1 nucleocytoplasmic transport 1 Q9UHL0,Q9NUU7 462 1.94e-02 324 3 2 0.667 0.006 GO:0051169 BP 1 nuclear transport 1 Q9UHL0,Q9NUU7 462 1.99e-02 1067 3 2 0.667 0.002 TF:M01303_0 tf 1 Factor: SP1; motif: GGGGYGGGGNS; match class: 0 1 Q9UHL0,Q15121 462 2.04e-02 1082 3 2 0.667 0.002 TF:M07278_1 tf 1 Factor: Dlx3; motif: NTAATTNVN; match class: 1 1 Q9UHL0,Q15121 462 2.16e-02 3548 3 3 1.000 0.001 TF:M00174_0 tf 1 Factor: AP-1; motif: NNTGACTCANN; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 2.31e-02 354 3 2 0.667 0.006 GO:0016887 MF 1 ATPase activity 1 Q9UHL0,Q9NUU7 462 2.57e-02 110 3 1 0.333 0.009 TF:M06215_0 tf 1 Factor: ZNF33b; motif: NTGTCCAANGGA; match class: 0 1 Q9UHL0 462 2.58e-02 374 3 2 0.667 0.005 GO:0071705 BP 1 nitrogen compound transport 1 Q9UHL0,Q9NUU7 462 2.80e-02 120 3 1 0.333 0.008 TF:M05297_0 tf 1 Factor: Sox-1; motif: TRAATATTWAA; match class: 0 1 Q9UHL0 462 2.89e-02 124 3 1 0.333 0.008 TF:M05825_0 tf 1 Factor: ZNF572; motif: NGGTAGDGAAGC; match class: 0 1 Q9UHL0 462 2.94e-02 126 3 1 0.333 0.008 TF:M01303_1 tf 1 Factor: SP1; motif: GGGGYGGGGNS; match class: 1 1 Q9UHL0 462 3.06e-02 131 3 1 0.333 0.008 TF:M05419_0 tf 1 Factor: ZNF499; motif: NGTTCCGGASGC; match class: 0 1 Q15121 462 3.26e-02 140 3 1 0.333 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 Q15121 462 3.62e-02 4212 3 3 1.000 0.001 TF:M04075_0 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 3.88e-02 4310 3 3 1.000 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 Q9UHL0,Q15121,Q9NUU7 462 3.94e-02 4332 3 3 1.000 0.001 TF:M04073_0 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 4.18e-02 180 3 1 0.333 0.006 TF:M04143_0 tf 1 Factor: TEAD3; motif: RCATTCCNNRCATWCCN; match class: 0 1 Q15121 462 4.27e-02 184 3 1 0.333 0.005 TF:M03875_0 tf 1 Factor: IRF-5; motif: KTTTCGCTTTCMT; match class: 0 1 Q9UHL0 462 4.28e-02 1588 3 2 0.667 0.001 TF:M03796_1 tf 1 Factor: MafA; motif: GGTCAGCAGH; match class: 1 1 Q9UHL0,Q9NUU7 462 4.35e-02 1602 3 2 0.667 0.001 TF:M00938_0 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 0 1 Q9UHL0,Q9NUU7 462 4.41e-02 1614 3 2 0.667 0.001 TF:M00285_0 tf 1 Factor: TCF11; motif: GTCATNNWNNNNN; match class: 0 1 Q9UHL0,Q15121 462 4.44e-02 191 3 1 0.333 0.005 TF:M04142_0 tf 1 Factor: TEAD1; motif: RCATTCCWNRCATTCCN; match class: 0 1 Q15121 462 4.50e-02 4529 3 3 1.000 0.001 TF:M01817_0 tf 1 Factor: TEF-1; motif: GWGGAATGT; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 4.61e-02 4563 3 3 1.000 0.001 TF:M00414_0 tf 1 Factor: AREB6; motif: VNRCACCTGKNC; match class: 0 1 Q9UHL0,Q15121,Q9NUU7 462 4.78e-02 1682 3 2 0.667 0.001 TF:M01778_1 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 1 1 Q9UHL0,Q15121 462 4.87e-02 210 3 1 0.333 0.005 TF:M04326_1 tf 1 Factor: GSC; motif: NYTAATCCNN; match class: 1 1 Q15121 462 4.98e-02 1719 3 2 0.667 0.001 TF:M05548_1 tf 1 Factor: PLAGL2; motif: AAGGACC; match class: 1 1 Q15121,Q9NUU7 462 5.00e-02 394 3 2 0.667 0.005 MI:hsa-miR-129-5p mi 1 MI:hsa-miR-129-5p 1 Q9UHL0,Q15121 462 5.00e-02 23 3 1 0.333 0.043 GO:0046324 BP 1 regulation of glucose import 1 Q15121 463 3.13e-06 4 4 2 0.500 0.500 GO:1990130 CC 1 Iml1 complex 1 O75140,Q8WTW4 463 4.74e-05 14 4 2 0.500 0.143 GO:0035859 CC 1 Seh1-associated complex 1 O75140,Q8WTW4 463 7.97e-05 18 4 2 0.500 0.111 GO:0034198 BP 1 cellular response to amino acid starvation 1 O75140,Q8WTW4 463 1.83e-04 27 4 2 0.500 0.074 GO:0032007 BP 1 negative regulation of TOR signaling 1 O75140,Q8WTW4 463 8.87e-04 59 4 2 0.500 0.034 GO:0032006 BP 1 regulation of TOR signaling 1 O75140,Q8WTW4 463 1.11e-03 66 4 2 0.500 0.030 GO:0009267 BP 1 cellular response to starvation 1 O75140,Q8WTW4 463 1.15e-03 67 4 2 0.500 0.030 GO:0031929 BP 1 TOR signaling 1 O75140,Q8WTW4 463 1.32e-03 72 4 2 0.500 0.028 GO:0042594 BP 1 response to starvation 1 O75140,Q8WTW4 463 1.76e-03 83 4 2 0.500 0.024 GO:0031669 BP 1 cellular response to nutrient levels 1 O75140,Q8WTW4 463 2.11e-03 91 4 2 0.500 0.022 GO:0031668 BP 1 cellular response to extracellular stimulus 1 O75140,Q8WTW4 463 2.98e-03 108 4 2 0.500 0.019 GO:0031667 BP 1 response to nutrient levels 1 O75140,Q8WTW4 463 3.61e-03 119 4 2 0.500 0.017 GO:0071496 BP 1 cellular response to external stimulus 1 O75140,Q8WTW4 463 3.61e-03 119 4 2 0.500 0.017 GO:0009991 BP 1 response to extracellular stimulus 1 O75140,Q8WTW4 463 4.28e-03 305 4 2 0.500 0.007 MI:mmu-miR-718 mi 1 MI:mmu-miR-718 1 O75140,Q96IQ9 463 4.39e-03 351 4 2 0.500 0.006 TF:M05629_0 tf 1 Factor: ZNF44; motif: KGATSGRGCCSC; match class: 0 1 O75140,Q8WTW4 463 6.59e-03 432 4 2 0.500 0.005 TF:M02094_0 tf 1 Factor: ERR3; motif: NNTCAAGGTCACN; match class: 0 1 O75140,O94953 463 7.10e-03 167 4 2 0.500 0.012 GO:0005096 MF 1 GTPase activator activity 1 O75140,Q8WTW4 463 7.21e-03 23 4 1 0.250 0.043 TF:M03993_0 tf 1 Factor: SPDEF; motif: GCAGNAAGAMGTAAMM; match class: 0 1 Q8WTW4 463 7.98e-03 1659 4 3 0.750 0.002 TF:M01013_0 tf 1 Factor: ipf1; motif: TSNGYCATTANNNNC; match class: 0 1 O75140,Q8WTW4,O94953 463 8.03e-03 478 4 2 0.500 0.004 TF:M01589_0 tf 1 Factor: ERR2; motif: YCAAGGTCANNN; match class: 0 1 O75140,O94953 463 8.15e-03 26 4 1 0.250 0.038 TF:M06506_0 tf 1 Factor: ZFP62; motif: TSGAGMTTATTY; match class: 0 1 Q8WTW4 463 8.54e-03 434 4 2 0.500 0.005 MI:hsa-miR-298 mi 1 MI:hsa-miR-298 1 O75140,O94953 463 8.73e-03 439 4 2 0.500 0.005 MI:mmu-miR-699 mi 1 MI:mmu-miR-699 1 O75140,Q8WTW4 463 8.80e-03 501 4 2 0.500 0.004 TF:M01078_1 tf 1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 1 Q8WTW4,Q96IQ9 463 9.65e-03 195 4 2 0.500 0.010 GO:0030695 MF 1 GTPase regulator activity 1 O75140,Q8WTW4 463 1.05e-02 482 4 2 0.500 0.004 MI:hsa-miR-769-3p mi 1 MI:hsa-miR-769-3p 1 O75140,Q96IQ9 463 1.09e-02 207 4 2 0.500 0.010 GO:0010506 BP 1 regulation of autophagy 1 O75140,Q8WTW4 463 1.11e-02 564 4 2 0.500 0.004 TF:M07360_1 tf 1 Factor: LRH-1; motif: NNNYCAAGGYCAN; match class: 1 1 O75140,Q8WTW4 463 1.25e-02 222 4 2 0.500 0.009 GO:0060589 MF 1 nucleoside-triphosphatase regulator activity 1 O75140,Q8WTW4 463 1.25e-02 1 4 1 0.250 1.000 OMIM:604364 omi 1 EPILEPSY, FAMILIAL FOCAL, WITH VARIABLE FOCI; FFEVF;;EPILEPSY, PARTIAL, WITH VARIABLE FOCI; FPEVF 1 O75140 463 1.26e-02 531 4 2 0.500 0.004 MI:hsa-miR-34c-5p mi 1 MI:hsa-miR-34c-5p 1 O75140,Q8WTW4 463 1.28e-02 41 4 1 0.250 0.024 TF:M06276_0 tf 1 Factor: ZNF642; motif: KGTAGYGAGATG; match class: 0 1 O75140 463 1.29e-02 610 4 2 0.500 0.003 TF:M03871_0 tf 1 Factor: GLI; motif: MCVNNGACCACCCAV; match class: 0 1 O75140,O94953 463 1.34e-02 43 4 1 0.250 0.023 TF:M06948_0 tf 1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 0 1 O94953 463 1.38e-02 556 4 2 0.500 0.004 MI:hsa-miR-34a mi 1 MI:hsa-miR-34a 1 O75140,Q8WTW4 463 1.43e-02 644 4 2 0.500 0.003 TF:M05962_0 tf 1 Factor: PRDM16; motif: NGKGCCSGCMT; match class: 0 1 O75140,Q8WTW4 463 1.60e-02 4525 4 4 1.000 0.001 TF:M01778_0 tf 1 Factor: PLAG1; motif: GRGGCNNHNNNRRGGG; match class: 0 1 O75140,Q8WTW4,O94953,Q96IQ9 463 1.60e-02 8 4 1 0.250 0.125 GO:1904262 BP 1 negative regulation of TORC1 signaling 1 O75140 463 1.67e-02 1 4 1 0.250 1.000 HP:0011158 hp 1 Auditory auras 1 O75140 463 1.67e-02 1 4 1 0.250 1.000 HP:0002349 hp 1 Focal seizures without impairment of consciousness or awareness 1 O75140 463 1.96e-02 21 4 1 0.250 0.048 REAC:3214842 rea 1 HDMs demethylate histones 1 O94953 463 2.06e-02 2310 4 3 0.750 0.001 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 Q8WTW4,O94953,Q96IQ9 463 2.14e-02 793 4 2 0.500 0.003 TF:M00072_1 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 1 1 Q8WTW4,Q96IQ9 463 2.14e-02 292 4 2 0.500 0.007 GO:1902532 BP 1 negative regulation of intracellular signal transduction 1 O75140,Q8WTW4 463 2.20e-02 11 4 1 0.250 0.091 GO:0006995 BP 1 cellular response to nitrogen starvation 1 Q8WTW4 463 2.20e-02 11 4 1 0.250 0.091 GO:0043562 BP 1 cellular response to nitrogen levels 1 Q8WTW4 463 2.22e-02 297 4 2 0.500 0.007 GO:0008047 MF 1 enzyme activator activity 1 O75140,Q8WTW4 463 2.24e-02 2378 4 3 0.750 0.001 TF:M07305_0 tf 1 Factor: RFX; motif: SNGTTGCYANGGA; match class: 0 1 O75140,O94953,Q96IQ9 463 2.34e-02 75 4 1 0.250 0.013 TF:M05310_1 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 1 1 Q96IQ9 463 2.38e-02 2428 4 3 0.750 0.001 TF:M02093_0 tf 1 Factor: ERR1; motif: CAAGGTCAMNN; match class: 0 1 O75140,Q8WTW4,O94953 463 2.55e-02 82 4 1 0.250 0.012 TF:M06210_0 tf 1 Factor: ZNF33a; motif: NGGGHTTAMCGA; match class: 0 1 Q8WTW4 463 2.58e-02 2500 4 3 0.750 0.001 TF:M01209_0 tf 1 Factor: GAF; motif: CRNATTCCYNK; match class: 0 1 O75140,Q8WTW4,Q96IQ9 463 2.60e-02 13 4 1 0.250 0.077 GO:1903432 BP 1 regulation of TORC1 signaling 1 O75140 463 2.72e-02 900 4 2 0.500 0.002 TF:M03565_1 tf 1 Factor: slug; motif: KCACCTGN; match class: 1 1 Q8WTW4,Q96IQ9 463 2.79e-02 911 4 2 0.500 0.002 TF:M01037_0 tf 1 Factor: GLI; motif: NBTGGGTGGTCN; match class: 0 1 O94953,Q96IQ9 463 2.80e-02 5209 4 4 1.000 0.001 TF:M07054_0 tf 1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 0 1 O75140,Q8WTW4,O94953,Q96IQ9 463 2.80e-02 14 4 1 0.250 0.071 GO:0038202 BP 1 TORC1 signaling 1 O75140 463 2.89e-02 340 4 2 0.500 0.006 GO:0006914 BP 1 autophagy 1 O75140,Q8WTW4 463 2.95e-02 5275 4 4 1.000 0.001 TF:M01100_1 tf 1 Factor: LRF; motif: VNNRMCCCC; match class: 1 1 O75140,Q8WTW4,O94953,Q96IQ9 463 3.04e-02 98 4 1 0.250 0.010 TF:M07050_1 tf 1 Factor: MITF; motif: NNCACATGNNN; match class: 1 1 Q8WTW4 463 3.11e-02 100 4 1 0.250 0.010 TF:M03967_0 tf 1 Factor: ELF3; motif: WACCCGGAAGTAN; match class: 0 1 Q8WTW4 463 3.14e-02 101 4 1 0.250 0.010 TF:M06317_0 tf 1 Factor: ZNF829; motif: KGGGSCARACGC; match class: 0 1 O94953 463 3.20e-02 103 4 1 0.250 0.010 TF:M01279_1 tf 1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 1 O75140 463 3.39e-02 1010 4 2 0.500 0.002 TF:M00727_1 tf 1 Factor: SF-1; motif: TGACCTTG; match class: 1 1 O75140,Q8WTW4 463 3.39e-02 1010 4 2 0.500 0.002 TF:M02000_1 tf 1 Factor: ERR3; motif: CAAGGTCA; match class: 1 1 O75140,Q8WTW4 463 3.39e-02 5462 4 4 1.000 0.001 TF:M00240_1 tf 1 Factor: Nkx2-5; motif: TYAAGTG; match class: 1 1 O75140,Q8WTW4,O94953,Q96IQ9 463 3.44e-02 111 4 1 0.250 0.009 TF:M04147_1 tf 1 Factor: TFAP2A; motif: NGCCYSAGGCN; match class: 1 1 Q8WTW4 463 3.49e-02 2781 4 3 0.750 0.001 TF:M04146_0 tf 1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 0 1 O75140,O94953,Q96IQ9 463 3.50e-02 113 4 1 0.250 0.009 TF:M07231_1 tf 1 Factor: TFAP2A; motif: NNNNGCCYSAGGGCA; match class: 1 1 O94953 463 3.53e-02 1032 4 2 0.500 0.002 TF:M07085_0 tf 1 Factor: E2F-6; motif: RGGCGGGARRN; match class: 0 1 O75140,Q8WTW4 463 3.54e-02 114 4 1 0.250 0.009 TF:M06155_0 tf 1 Factor: ZNF135; motif: NGTKGTGWAATC; match class: 0 1 O94953 463 3.54e-02 114 4 1 0.250 0.009 TF:M05650_0 tf 1 Factor: ZNF44; motif: NWTTTCTAACCC; match class: 0 1 O94953 463 3.55e-02 1036 4 2 0.500 0.002 TF:M07253_0 tf 1 Factor: ERR2; motif: NTGACCTTGA; match class: 0 1 O75140,O94953 463 3.55e-02 1036 4 2 0.500 0.002 TF:M01132_0 tf 1 Factor: SF1; motif: TGACCTTGN; match class: 0 1 O75140,O94953 463 3.57e-02 115 4 1 0.250 0.009 TF:M01588_1 tf 1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 1 Q96IQ9 463 3.61e-02 5547 4 4 1.000 0.001 TF:M04152_1 tf 1 Factor: TFAP2C; motif: NGCCCNNRGGCA; match class: 1 1 O75140,Q8WTW4,O94953,Q96IQ9 463 3.68e-02 1055 4 2 0.500 0.002 TF:M00201_1 tf 1 Factor: C/EBP; motif: NGWVTKNKGYAAKNSAYA; match class: 1 1 O75140,O94953 463 3.75e-02 2855 4 3 0.750 0.001 TF:M00955_0 tf 1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 0 1 O75140,O94953,Q96IQ9 463 3.81e-02 123 4 1 0.250 0.008 TF:M03901_1 tf 1 Factor: GLI2; motif: GACCACCCACNNNG; match class: 1 1 O94953 463 3.81e-02 123 4 1 0.250 0.008 TF:M00261_0 tf 1 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN; match class: 0 1 O75140 463 3.86e-02 394 4 2 0.500 0.005 GO:0005773 CC 1 vacuole 1 O75140,Q8WTW4 463 4.24e-02 137 4 1 0.250 0.007 TF:M06701_0 tf 1 Factor: ZNF319; motif: NGGTWAAACCGA; match class: 0 1 Q96IQ9 463 4.24e-02 1138 4 2 0.500 0.002 TF:M01593_1 tf 1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 1 1 O94953,Q96IQ9 463 4.24e-02 2983 4 3 0.750 0.001 TF:M03554_1 tf 1 Factor: NF-1A; motif: NGCCARN; match class: 1 1 O75140,Q8WTW4,O94953 463 4.39e-02 142 4 1 0.250 0.007 TF:M00938_1 tf 1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 1 Q96IQ9 463 4.45e-02 3035 4 3 0.750 0.001 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 O75140,O94953,Q96IQ9 463 4.58e-02 3066 4 3 0.750 0.001 TF:M02273_0 tf 1 Factor: NURR1; motif: AAGGTCAC; match class: 0 1 O75140,Q8WTW4,O94953 463 4.66e-02 5915 4 4 1.000 0.001 TF:M03572_0 tf 1 Factor: DEC1; motif: CNCACRTGASC; match class: 0 1 O75140,Q8WTW4,O94953,Q96IQ9 463 4.66e-02 3086 4 3 0.750 0.001 TF:M07265_0 tf 1 Factor: Nrf2; motif: NNTGACTCAGCAN; match class: 0 1 O75140,Q8WTW4,O94953 463 4.81e-02 1217 4 2 0.500 0.002 TF:M07226_1 tf 1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 1 O75140,Q96IQ9 463 4.87e-02 1225 4 2 0.500 0.002 TF:M00807_1 tf 1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 1 O94953,Q96IQ9 463 4.90e-02 5990 4 4 1.000 0.001 TF:M02111_1 tf 1 Factor: NR1B2; motif: NTGACCY; match class: 1 1 O75140,Q8WTW4,O94953,Q96IQ9 463 4.91e-02 53 4 1 0.250 0.019 REAC:5693565 rea 1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 1 O94953 463 4.94e-02 6001 4 4 1.000 0.001 TF:M03582_1 tf 1 Factor: TWIST; motif: CACCTGG; match class: 1 1 O75140,Q8WTW4,O94953,Q96IQ9 463 5.00e-02 54 4 1 0.250 0.019 REAC:5693606 rea 1 DNA Double Strand Break Response 1 O94953 463 5.00e-02 3 4 1 0.250 0.333 HP:0011157 hp 1 Auras 1 O75140 463 5.00e-02 4 4 1 0.250 0.250 OMIM:600513 omi 1 Nocturnal Frontal Lobe Epilepsy 1 O75140 463 5.00e-02 25 4 1 0.250 0.040 GO:0032452 MF 1 histone demethylase activity 1 O94953 463 5.00e-02 134 4 2 0.500 0.015 KEGG:04150 keg 1 mTOR signaling pathway 1 O75140,Q8WTW4 464 1.02e-06 9 2 2 1.000 0.222 GO:0008392 MF 1 arachidonic acid epoxygenase activity 1 P33260,P11712 464 1.02e-06 9 2 2 1.000 0.222 GO:0008391 MF 1 arachidonic acid monooxygenase activity 1 P33260,P11712 464 1.27e-06 10 2 2 1.000 0.200 GO:0019373 BP 1 epoxygenase P450 pathway 1 P33260,P11712 464 2.99e-06 13 2 2 1.000 0.154 REAC:211981 rea 1 Xenobiotics 1 P33260,P11712 464 3.39e-06 16 2 2 1.000 0.125 GO:0019825 MF 1 oxygen binding 1 P33260,P11712 464 4.32e-06 18 2 2 1.000 0.111 GO:0008395 MF 1 steroid hydroxylase activity 1 P33260,P11712 464 1.23e-05 30 2 2 1.000 0.067 GO:0019369 BP 1 arachidonic acid metabolic process 1 P33260,P11712 464 1.45e-05 28 2 2 1.000 0.071 REAC:211897 rea 1 Cytochrome P450 - arranged by substrate type 1 P33260,P11712 464 3.05e-05 47 2 2 1.000 0.043 GO:0004497 MF 1 monooxygenase activity 1 P33260,P11712 464 3.46e-05 50 2 2 1.000 0.040 GO:0006690 BP 1 icosanoid metabolic process 1 P33260,P11712 464 3.46e-05 50 2 2 1.000 0.040 GO:1901568 BP 1 fatty acid derivative metabolic process 1 P33260,P11712 464 3.79e-05 45 2 2 1.000 0.044 REAC:211945 rea 1 Phase 1 - Functionalization of compounds 1 P33260,P11712 464 4.35e-05 56 2 2 1.000 0.036 GO:0001676 BP 1 long-chain fatty acid metabolic process 1 P33260,P11712 464 5.17e-05 61 2 2 1.000 0.033 GO:0006805 BP 1 xenobiotic metabolic process 1 P33260,P11712 464 5.34e-05 62 2 2 1.000 0.032 GO:0071466 BP 1 cellular response to xenobiotic stimulus 1 P33260,P11712 464 5.34e-05 62 2 2 1.000 0.032 GO:0009410 BP 1 response to xenobiotic stimulus 1 P33260,P11712 464 6.06e-05 66 2 2 1.000 0.030 GO:0033559 BP 1 unsaturated fatty acid metabolic process 1 P33260,P11712 464 7.11e-05 40 2 2 1.000 0.050 KEGG:00830 keg 1 Retinol metabolism 1 P33260,P11712 464 1.06e-04 87 2 2 1.000 0.023 GO:0016705 MF 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1 P33260,P11712 464 1.51e-04 58 2 2 1.000 0.034 KEGG:05204 keg 1 Chemical carcinogenesis 1 P33260,P11712 464 3.07e-04 127 2 2 1.000 0.016 REAC:211859 rea 1 Biological oxidations 1 P33260,P11712 464 3.10e-04 83 2 2 1.000 0.024 KEGG:04726 keg 1 Serotonergic synapse 1 P33260,P11712 464 5.79e-04 203 2 2 1.000 0.010 GO:0006631 BP 1 fatty acid metabolic process 1 P33260,P11712 464 6.52e-04 2 2 1 0.500 0.500 GO:0034875 MF 1 caffeine oxidase activity 1 P11712 464 6.52e-04 2 2 1 0.500 0.500 GO:0033695 MF 1 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor 1 P11712 464 1.30e-03 4 2 1 0.500 0.250 GO:0016098 BP 1 monoterpenoid metabolic process 1 P11712 464 1.38e-03 5 2 1 0.500 0.200 REAC:2142816 rea 1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 1 P11712 464 1.41e-03 9 2 1 0.500 0.111 TF:M06572_0 tf 1 Factor: ZNF597; motif: KGGTAATTGAGA; match class: 0 1 P33260 464 1.63e-03 5 2 1 0.500 0.200 GO:0097267 BP 1 omega-hydroxylase P450 pathway 1 P11712 464 1.66e-03 6 2 1 0.500 0.167 REAC:2142670 rea 1 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 1 P11712 464 1.76e-03 353 2 2 1.000 0.006 GO:0032787 BP 1 monocarboxylic acid metabolic process 1 P33260,P11712 464 2.21e-03 8 2 1 0.500 0.125 REAC:211999 rea 1 CYP2E1 reactions 1 P11712 464 2.28e-03 7 2 1 0.500 0.143 GO:0042738 BP 1 exogenous drug catabolic process 1 P11712 464 2.28e-03 7 2 1 0.500 0.143 GO:0016725 MF 1 oxidoreductase activity, acting on CH or CH2 groups 1 P11712 464 2.36e-03 15 2 1 0.500 0.067 TF:M04079_1 tf 1 Factor: POU3F2; motif: WTATGCWAATKA; match class: 1 1 P33260 464 2.93e-03 9 2 1 0.500 0.111 GO:0042737 BP 1 drug catabolic process 1 P11712 464 3.25e-03 480 2 2 1.000 0.004 GO:0016491 MF 1 oxidoreductase activity 1 P33260,P11712 464 3.58e-03 11 2 1 0.500 0.091 GO:0019627 BP 1 urea metabolic process 1 P11712 464 3.68e-03 773 2 2 1.000 0.003 TF:M00294_1 tf 1 Factor: HFH8; motif: NNNTGTTTATNTR; match class: 1 1 P33260,P11712 464 3.91e-03 12 2 1 0.500 0.083 GO:0070989 BP 1 oxidative demethylation 1 P11712 464 3.91e-03 12 2 1 0.500 0.083 GO:0071941 BP 1 nitrogen cycle metabolic process 1 P11712 464 3.93e-03 528 2 2 1.000 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 P33260,P11712 464 4.02e-03 534 2 2 1.000 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 P33260,P11712 464 5.52e-03 946 2 2 1.000 0.002 TF:M00729_1 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 1 1 P33260,P11712 464 5.65e-03 633 2 2 1.000 0.003 GO:0044255 BP 1 cellular lipid metabolic process 1 P33260,P11712 464 5.96e-03 650 2 2 1.000 0.003 GO:0019752 BP 1 carboxylic acid metabolic process 1 P33260,P11712 464 5.99e-03 13 2 1 0.500 0.077 KEGG:00591 keg 1 Linoleic acid metabolism 1 P11712 464 6.11e-03 658 2 2 1.000 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 P33260,P11712 464 7.13e-03 1075 2 2 1.000 0.002 TF:M04291_0 tf 1 Factor: BARX1; motif: NCMATTAN; match class: 0 1 P33260,P11712 464 7.49e-03 23 2 1 0.500 0.043 GO:0017144 BP 1 drug metabolic process 1 P11712 464 7.50e-03 729 2 2 1.000 0.003 GO:0043436 BP 1 oxoacid metabolic process 1 P33260,P11712 464 7.70e-03 739 2 2 1.000 0.003 GO:0006082 BP 1 organic acid metabolic process 1 P33260,P11712 464 8.25e-03 765 2 2 1.000 0.003 GO:0006629 BP 1 lipid metabolic process 1 P33260,P11712 464 8.62e-03 55 2 1 0.500 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 P33260 464 8.84e-03 32 2 1 0.500 0.031 REAC:2142753 rea 1 Arachidonic acid metabolism 1 P11712 464 9.41e-03 60 2 1 0.500 0.017 TF:M06446_0 tf 1 Factor: ZNF525; motif: NSTTAAAYCAGA; match class: 0 1 P33260 464 1.00e-02 1276 2 2 1.000 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 P33260,P11712 464 1.03e-02 66 2 1 0.500 0.015 TF:M04251_0 tf 1 Factor: FOXJ3; motif: GTAAACATAAACA; match class: 0 1 P33260 464 1.23e-02 933 2 2 1.000 0.002 GO:0005783 CC 1 endoplasmic reticulum 1 P33260,P11712 464 1.24e-02 38 2 1 0.500 0.026 GO:0070988 BP 1 demethylation 1 P11712 464 1.50e-02 96 2 1 0.500 0.010 TF:M05944_0 tf 1 Factor: ZNF552; motif: NWTTGCTGRMGA; match class: 0 1 P33260 464 1.53e-02 98 2 1 0.500 0.010 TF:M06739_0 tf 1 Factor: ZNF358; motif: NTRTGAAGAATM; match class: 0 1 P33260 464 1.53e-02 98 2 1 0.500 0.010 TF:M03947_1 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 1 1 P33260 464 1.65e-02 36 2 1 0.500 0.028 KEGG:00590 keg 1 Arachidonic acid metabolism 1 P11712 464 1.69e-02 52 2 1 0.500 0.019 GO:0008144 MF 1 drug binding 1 P11712 464 1.75e-02 1686 2 2 1.000 0.001 TF:M00162_1 tf 1 Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 1 1 P33260,P11712 464 1.76e-02 54 2 1 0.500 0.019 GO:0006721 BP 1 terpenoid metabolic process 1 P11712 464 1.80e-02 115 2 1 0.500 0.009 TF:M03947_0 tf 1 Factor: GRHL1; motif: AAAACCGGTTTN; match class: 0 1 P33260 464 1.86e-02 119 2 1 0.500 0.008 TF:M04076_1 tf 1 Factor: POU3F1; motif: WTATGCWAATNN; match class: 1 1 P33260 464 1.86e-02 1737 2 2 1.000 0.001 TF:M01011_1 tf 1 Factor: HNF1; motif: NNNNGNTAAWNATTAACYNNN; match class: 1 1 P33260,P11712 464 1.86e-02 1737 2 2 1.000 0.001 TF:M00350_1 tf 1 Factor: GATA-3; motif: NGAGATAANA; match class: 1 1 P33260,P11712 464 1.92e-02 123 2 1 0.500 0.008 TF:M05313_1 tf 1 Factor: ZNF536; motif: AATAYGCC; match class: 1 1 P33260 464 2.08e-02 1835 2 2 1.000 0.001 TF:M00406_0 tf 1 Factor: MEF-2A; motif: SKYTAAAAATAACYCH; match class: 0 1 P33260,P11712 464 2.09e-02 134 2 1 0.500 0.007 TF:M00186_0 tf 1 Factor: SRF; motif: GNCCAWATAWGGMN; match class: 0 1 P33260 464 2.09e-02 134 2 1 0.500 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 P33260 464 2.09e-02 134 2 1 0.500 0.007 TF:M04074_1 tf 1 Factor: POU2F3; motif: TATGCWAAT; match class: 1 1 P33260 464 2.19e-02 140 2 1 0.500 0.007 TF:M00437_0 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 0 1 P33260 464 2.21e-02 68 2 1 0.500 0.015 GO:0006720 BP 1 isoprenoid metabolic process 1 P11712 464 2.27e-02 1918 2 2 1.000 0.001 TF:M04299_1 tf 1 Factor: DLX1; motif: NNTAATTANN; match class: 1 1 P33260,P11712 464 2.37e-02 1959 2 2 1.000 0.001 TF:M04626_0 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 0 1 P33260,P11712 464 2.39e-02 52 2 1 0.500 0.019 KEGG:00982 keg 1 Drug metabolism - cytochrome P450 1 P11712 464 2.45e-02 1994 2 2 1.000 0.001 TF:M00980_1 tf 1 Factor: TBP; motif: TTTATAN; match class: 1 1 P33260,P11712 464 2.51e-02 1333 2 2 1.000 0.002 GO:0044281 BP 1 small molecule metabolic process 1 P33260,P11712 464 2.52e-02 55 2 1 0.500 0.018 KEGG:00980 keg 1 Metabolism of xenobiotics by cytochrome P450 1 P11712 464 2.75e-02 2111 2 2 1.000 0.001 TF:M04073_1 tf 1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1 P33260,P11712 464 2.82e-02 2137 2 2 1.000 0.001 TF:M00789_1 tf 1 Factor: GATA; motif: WGATARN; match class: 1 1 P33260,P11712 464 2.82e-02 2137 2 2 1.000 0.001 TF:M03216_1 tf 1 Factor: GATA-6; motif: AGATAAN; match class: 1 1 P33260,P11712 464 2.86e-02 1423 2 2 1.000 0.001 GO:0070887 BP 1 cellular response to chemical stimulus 1 P33260,P11712 464 2.92e-02 90 2 1 0.500 0.011 GO:0042493 BP 1 response to drug 1 P11712 464 2.93e-02 188 2 1 0.500 0.005 TF:M04626_1 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 1 1 P11712 464 3.09e-02 2236 2 2 1.000 0.001 TF:M04344_1 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 1 1 P33260,P11712 464 3.09e-02 198 2 1 0.500 0.005 TF:M01067_1 tf 1 Factor: Gfi1; motif: NNAAATCANNGSN; match class: 1 1 P33260 464 3.14e-02 2255 2 2 1.000 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 P33260,P11712 464 3.14e-02 2257 2 2 1.000 0.001 TF:M04075_1 tf 1 Factor: POU2F3; motif: ATGMATATKCAW; match class: 1 1 P33260,P11712 464 3.15e-02 202 2 1 0.500 0.005 TF:M00510_1 tf 1 Factor: Lhx3a; motif: AWTTAATTAA; match class: 1 1 P33260 464 3.35e-02 215 2 1 0.500 0.005 TF:M03948_1 tf 1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 1 P33260 464 3.38e-02 217 2 1 0.500 0.005 TF:M00810_0 tf 1 Factor: SRF; motif: SCCAWATAWGGMNMNNNN; match class: 0 1 P33260 464 3.59e-02 2412 2 2 1.000 0.001 TF:M03561_1 tf 1 Factor: POU2F1; motif: NNATTTGCATNN; match class: 1 1 P33260,P11712 464 3.60e-02 231 2 1 0.500 0.004 TF:M06279_0 tf 1 Factor: ZNF124; motif: WGGCGTCAGA; match class: 0 1 P33260 464 3.70e-02 238 2 1 0.500 0.004 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 P33260 464 3.85e-02 2498 2 2 1.000 0.001 TF:M03999_0 tf 1 Factor: GATA5; motif: WGATAANN; match class: 0 1 P33260,P11712 464 3.85e-02 2498 2 2 1.000 0.001 TF:M07214_0 tf 1 Factor: GATA3; motif: AGATAAGA; match class: 0 1 P33260,P11712 464 3.87e-02 249 2 1 0.500 0.004 TF:M00405_1 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 1 1 P11712 464 3.90e-02 433 2 2 1.000 0.005 MI:hsa-miR-299-3p mi 1 MI:hsa-miR-299-3p 1 P33260,P11712 464 3.92e-02 2519 2 2 1.000 0.001 TF:M00744_1 tf 1 Factor: POU1F1; motif: ATGAATAAWT; match class: 1 1 P33260,P11712 464 4.00e-02 2546 2 2 1.000 0.001 TF:M00941_0 tf 1 Factor: MEF-2; motif: RGCTATWTTTAR; match class: 0 1 P33260,P11712 464 4.04e-02 260 2 1 0.500 0.004 TF:M00080_0 tf 1 Factor: Evi-1; motif: AGATAAGATAA; match class: 0 1 P33260 464 4.14e-02 266 2 1 0.500 0.004 TF:M04355_1 tf 1 Factor: HOXC12; motif: GYAATAAAA; match class: 1 1 P11712 464 4.14e-02 266 2 1 0.500 0.004 TF:M07377_1 tf 1 Factor: cdx-1; motif: NTTTATKNN; match class: 1 1 P11712 464 4.24e-02 2622 2 2 1.000 0.001 TF:M00077_1 tf 1 Factor: GATA-3; motif: NNGATARNG; match class: 1 1 P33260,P11712 464 4.26e-02 274 2 1 0.500 0.004 TF:M04313_1 tf 1 Factor: EMX1; motif: YAATTARYTAATKA; match class: 1 1 P33260 464 4.32e-02 2646 2 2 1.000 0.001 TF:M00632_0 tf 1 Factor: GATA-4; motif: AGATADMAGGGA; match class: 0 1 P33260,P11712 464 4.37e-02 281 2 1 0.500 0.004 TF:M03919_1 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 1 1 P11712 464 4.52e-02 291 2 1 0.500 0.003 TF:M04303_1 tf 1 Factor: DLX5; motif: NYAATTAN; match class: 1 1 P11712 464 4.53e-02 140 2 1 0.500 0.007 GO:0008202 BP 1 steroid metabolic process 1 P11712 464 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 P33260,P11712 464 4.71e-02 2762 2 2 1.000 0.001 TF:M04317_1 tf 1 Factor: EN1; motif: TAATTRSNYAATTA; match class: 1 1 P33260,P11712 464 4.74e-02 305 2 1 0.500 0.003 TF:M00930_1 tf 1 Factor: Oct-1; motif: TNATTTGCATW; match class: 1 1 P33260 464 4.77e-02 2781 2 2 1.000 0.001 TF:M07421_1 tf 1 Factor: HOXC-8; motif: GAATWAYARN; match class: 1 1 P33260,P11712 464 4.89e-02 2816 2 2 1.000 0.001 TF:M00206_0 tf 1 Factor: HNF-1; motif: DGTTAATKAWTNACCAM; match class: 0 1 P33260,P11712 464 4.98e-02 321 2 1 0.500 0.003 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 P33260 464 5.00e-02 2 2 1 0.500 0.500 OMIM:122700 omi 1 COUMARIN RESISTANCE;;COUMARIN, POOR METABOLISM OF;;WARFARIN RESISTANCECOUMARIN SENSITIVITY, INCLUDED;;WARFARIN SENSITIVITY, INCLUDED 1 P11712 464 5.00e-02 490 2 2 1.000 0.004 MI:mmu-miR-465b-5p mi 1 MI:mmu-miR-465b-5p 1 P33260,P11712 464 5.00e-02 1048 2 2 1.000 0.002 KEGG:01100 keg 1 Metabolic pathways 1 P33260,P11712 464 5.00e-02 1882 2 2 1.000 0.001 GO:0042221 BP 1 response to chemical 1 P33260,P11712 465 7.12e-03 5 2 1 0.500 0.200 TF:M04613_1 tf 1 Factor: HLTF; motif: AGSCARAAAGYRGSTGS; match class: 1 1 Q56A73 465 1.62e-02 538 2 2 1.000 0.004 TF:M01595_1 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 1 1 Q9Y657,Q56A73 465 1.71e-02 12 2 1 0.500 0.083 TF:M06534_1 tf 1 Factor: ZNF563; motif: KGGKGCCGGMGG; match class: 1 1 Q9Y657 465 2.48e-02 667 2 2 1.000 0.003 TF:M07108_0 tf 1 Factor: MafF; motif: NCTNASTCAGCANWWTNN; match class: 0 1 Q9Y657,Q56A73 465 3.70e-02 26 2 1 0.500 0.038 TF:M00437_1 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 1 1 Q9Y657 465 3.70e-02 26 2 1 0.500 0.038 TF:M06015_0 tf 1 Factor: ZNF729; motif: NTKGGGAGAYCA; match class: 0 1 Q56A73 465 3.98e-02 28 2 1 0.500 0.036 TF:M07367_1 tf 1 Factor: Slug; motif: SSSNNNKCACCTGN; match class: 1 1 Q9Y657 465 5.00e-02 946 2 2 1.000 0.002 TF:M00729_1 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 1 1 Q9Y657,Q56A73 465 5.00e-02 22 2 1 0.500 0.045 GO:0009303 BP 1 rRNA transcription 1 Q9Y657 466 2.36e-03 15 2 1 0.500 0.067 TF:M06652_0 tf 1 Factor: ZNF696; motif: KGGTCMGAAAGM; match class: 0 1 A2RTX5 466 2.67e-03 17 2 1 0.500 0.059 TF:M06774_0 tf 1 Factor: ZNF629; motif: NWAATAAGMATA; match class: 0 1 O00560 466 2.94e-03 1 2 1 0.500 1.000 GO:0005895 CC 1 interleukin-5 receptor complex 1 O00560 466 2.94e-03 1 2 1 0.500 1.000 GO:0005137 MF 1 interleukin-5 receptor binding 1 O00560 466 3.79e-03 7 2 1 0.500 0.143 REAC:447043 rea 1 Neurofascin interactions 1 O00560 466 6.43e-03 41 2 1 0.500 0.024 TF:M06919_0 tf 1 Factor: ZNF652; motif: KKTTGAGGCTTA; match class: 0 1 O00560 466 6.90e-03 44 2 1 0.500 0.023 TF:M06392_0 tf 1 Factor: ZNF765; motif: NGGGCAARCATA; match class: 0 1 O00560 466 8.47e-03 54 2 1 0.500 0.019 TF:M04345_1 tf 1 Factor: HOXB13; motif: CCAATAAAAN; match class: 1 1 A2RTX5 466 8.83e-03 3 2 1 0.500 0.333 GO:0006435 BP 1 threonyl-tRNA aminoacylation 1 A2RTX5 466 8.83e-03 3 2 1 0.500 0.333 GO:0004829 MF 1 threonine-tRNA ligase activity 1 A2RTX5 466 8.83e-03 3 2 1 0.500 0.333 GO:1903553 BP 1 positive regulation of extracellular exosome assembly 1 O00560 466 9.19e-03 17 2 1 0.500 0.059 REAC:3928664 rea 1 Ephrin signaling 1 O00560 466 1.00e-02 64 2 1 0.500 0.016 TF:M07385_1 tf 1 Factor: Lhx2; motif: NYTAATTASNK; match class: 1 1 A2RTX5 466 1.38e-02 88 2 1 0.500 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 O00560 466 1.44e-02 1530 2 2 1.000 0.001 TF:M04363_0 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 0 1 O00560,A2RTX5 466 1.44e-02 1530 2 2 1.000 0.001 TF:M04357_0 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 0 1 O00560,A2RTX5 466 1.47e-02 5 2 1 0.500 0.200 GO:1903551 BP 1 regulation of extracellular exosome assembly 1 O00560 466 1.47e-02 5 2 1 0.500 0.200 GO:0045545 MF 1 syndecan binding 1 O00560 466 1.47e-02 5 2 1 0.500 0.200 GO:0071971 BP 1 extracellular exosome assembly 1 O00560 466 1.75e-02 112 2 1 0.500 0.009 TF:M04363_1 tf 1 Factor: HOXD13; motif: CYMATAAAAN; match class: 1 1 A2RTX5 466 1.75e-02 112 2 1 0.500 0.009 TF:M04357_1 tf 1 Factor: HOXC13; motif: CYAATAAAAN; match class: 1 1 A2RTX5 466 1.77e-02 6 2 1 0.500 0.167 GO:0002091 BP 1 negative regulation of receptor internalization 1 O00560 466 1.77e-02 6 2 1 0.500 0.167 GO:0006930 BP 1 substrate-dependent cell migration, cell extension 1 O00560 466 1.94e-02 124 2 1 0.500 0.008 TF:M05358_0 tf 1 Factor: RLF; motif: GCATCRWCATT; match class: 0 1 A2RTX5 466 1.94e-02 124 2 1 0.500 0.008 TF:M06124_0 tf 1 Factor: ZNF806; motif: GGTWRAAACSM; match class: 0 1 A2RTX5 466 2.08e-02 133 2 1 0.500 0.008 TF:M06159_0 tf 1 Factor: ZNF83; motif: NTGGCAAARARM; match class: 0 1 O00560 466 2.14e-02 1864 2 2 1.000 0.001 TF:M03899_0 tf 1 Factor: EGR4; motif: NNMCGCCCACGCANNN; match class: 0 1 O00560,A2RTX5 466 2.19e-02 140 2 1 0.500 0.007 TF:M00437_0 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 0 1 O00560 466 2.27e-02 1916 2 2 1.000 0.001 TF:M04319_1 tf 1 Factor: ESX1; motif: NNYAATTANN; match class: 1 1 O00560,A2RTX5 466 2.27e-02 145 2 1 0.500 0.007 TF:M07264_1 tf 1 Factor: NF-AT2; motif: TGGAAANWN; match class: 1 1 O00560 466 2.32e-02 1939 2 2 1.000 0.001 TF:M00096_1 tf 1 Factor: Pbx-1; motif: ATCAATCAW; match class: 1 1 O00560,A2RTX5 466 2.35e-02 1951 2 2 1.000 0.001 TF:M01267_0 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 0 1 O00560,A2RTX5 466 2.35e-02 1951 2 2 1.000 0.001 TF:M00926_0 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 0 1 O00560,A2RTX5 466 2.37e-02 152 2 1 0.500 0.007 TF:M05756_0 tf 1 Factor: ZNF470; motif: NTGTTTAWKAWA; match class: 0 1 A2RTX5 466 2.67e-02 171 2 1 0.500 0.006 TF:M01267_1 tf 1 Factor: Fra-1; motif: TGAGTCAN; match class: 1 1 O00560 466 2.67e-02 171 2 1 0.500 0.006 TF:M00926_1 tf 1 Factor: AP-1; motif: TGAGTCAN; match class: 1 1 O00560 466 2.72e-02 174 2 1 0.500 0.006 TF:M06320_0 tf 1 Factor: ZNF791; motif: NGGTTATGAMGA; match class: 0 1 A2RTX5 466 2.86e-02 2153 2 2 1.000 0.001 TF:M04341_0 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 0 1 O00560,A2RTX5 466 3.09e-02 2236 2 2 1.000 0.001 TF:M04344_1 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 1 1 O00560,A2RTX5 466 3.17e-02 2266 2 2 1.000 0.001 TF:M00687_0 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 0 1 O00560,A2RTX5 466 3.24e-02 11 2 1 0.500 0.091 GO:0048261 BP 1 negative regulation of receptor-mediated endocytosis 1 O00560 466 3.35e-02 215 2 1 0.500 0.005 TF:M07082_0 tf 1 Factor: DUX4; motif: TAAYYYAATCA; match class: 0 1 A2RTX5 466 3.36e-02 2334 2 2 1.000 0.001 TF:M04403_1 tf 1 Factor: MNX1; motif: NNYAATTAAN; match class: 1 1 O00560,A2RTX5 466 3.37e-02 216 2 1 0.500 0.005 TF:M00145_1 tf 1 Factor: Brn-2; motif: NNCATNSRWAATNMRN; match class: 1 1 A2RTX5 466 3.45e-02 2365 2 2 1.000 0.001 TF:M00925_0 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 0 1 O00560,A2RTX5 466 3.52e-02 226 2 1 0.500 0.004 TF:M00925_1 tf 1 Factor: AP-1; motif: NTGACTCAN; match class: 1 1 O00560 466 3.55e-02 228 2 1 0.500 0.004 TF:M04341_1 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 1 1 A2RTX5 466 3.78e-02 243 2 1 0.500 0.004 TF:M00641_0 tf 1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 0 1 A2RTX5 466 3.82e-02 13 2 1 0.500 0.077 GO:1903543 BP 1 positive regulation of exosomal secretion 1 O00560 466 4.12e-02 14 2 1 0.500 0.071 GO:0006929 BP 1 substrate-dependent cell migration 1 O00560 466 4.12e-02 14 2 1 0.500 0.071 GO:0008093 MF 1 cytoskeletal adaptor activity 1 O00560 466 4.13e-02 2588 2 2 1.000 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 O00560,A2RTX5 466 4.17e-02 2601 2 2 1.000 0.001 TF:M02280_1 tf 1 Factor: AP1; motif: TGACTCA; match class: 1 1 O00560,A2RTX5 466 4.24e-02 2620 2 2 1.000 0.001 TF:M07309_0 tf 1 Factor: Sox7; motif: NACAATDGA; match class: 0 1 O00560,A2RTX5 466 4.26e-02 2628 2 2 1.000 0.001 TF:M04393_1 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 1 1 O00560,A2RTX5 466 4.42e-02 250 2 1 0.500 0.004 MI:hsa-miR-195* mi 1 MI:hsa-miR-195* 1 A2RTX5 466 4.42e-02 2675 2 2 1.000 0.001 TF:M04312_1 tf 1 Factor: EMX1; motif: NNTAATTANN; match class: 1 1 O00560,A2RTX5 466 4.46e-02 287 2 1 0.500 0.003 TF:M04381_1 tf 1 Factor: ISX; motif: NYAATTAN; match class: 1 1 A2RTX5 466 4.46e-02 287 2 1 0.500 0.003 TF:M04416_1 tf 1 Factor: NKX6-2; motif: NYMATTAA; match class: 1 1 A2RTX5 466 4.47e-02 2690 2 2 1.000 0.001 TF:M01137_1 tf 1 Factor: FOXO3A; motif: TRTAAACAANWN; match class: 1 1 O00560,A2RTX5 466 4.47e-02 83 2 1 0.500 0.012 REAC:2682334 rea 1 EPH-Ephrin signaling 1 O00560 466 4.71e-02 16 2 1 0.500 0.062 GO:1903541 BP 1 regulation of exosomal secretion 1 O00560 466 4.71e-02 16 2 1 0.500 0.062 GO:0032435 BP 1 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 1 O00560 466 4.78e-02 308 2 1 0.500 0.003 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 A2RTX5 466 4.81e-02 310 2 1 0.500 0.003 TF:M00808_1 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 1 1 A2RTX5 466 4.95e-02 319 2 1 0.500 0.003 TF:M03551_1 tf 1 Factor: JunB; motif: TGACTCAN; match class: 1 1 A2RTX5 466 5.00e-02 2846 2 2 1.000 0.001 TF:M04392_1 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 1 1 O00560,A2RTX5 466 5.00e-02 44 2 1 0.500 0.023 KEGG:00970 keg 1 Aminoacyl-tRNA biosynthesis 1 A2RTX5 466 5.00e-02 93 2 1 0.500 0.011 REAC:373760 rea 1 L1CAM interactions 1 O00560 466 5.00e-02 17 2 1 0.500 0.059 GO:1903846 BP 1 positive regulation of cellular response to transforming growth factor beta stimulus 1 O00560 466 5.00e-02 17 2 1 0.500 0.059 GO:0030511 BP 1 positive regulation of transforming growth factor beta receptor signaling pathway 1 O00560 467 9.28e-04 1 2 1 0.500 1.000 GO:0051424 MF 1 corticotropin-releasing hormone binding 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0051460 BP 1 negative regulation of corticotropin secretion 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0043196 CC 1 varicosity 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:1900010 BP 1 regulation of corticotropin-releasing hormone receptor activity 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0051458 BP 1 corticotropin secretion 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0052250 BP 1 modulation of signal transduction in other organism involved in symbiotic interaction 1 Q15025 467 9.28e-04 1 2 1 0.500 1.000 GO:0051459 BP 1 regulation of corticotropin secretion 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0071314 BP 1 cellular response to cocaine 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0052027 BP 1 modulation by symbiont of host signal transduction pathway 1 Q15025 467 9.28e-04 1 2 1 0.500 1.000 GO:1900011 BP 1 negative regulation of corticotropin-releasing hormone receptor activity 1 P24387 467 9.28e-04 1 2 1 0.500 1.000 GO:0044501 BP 1 modulation of signal transduction in other organism 1 Q15025 467 9.28e-04 1 2 1 0.500 1.000 GO:0085032 BP 1 modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade 1 Q15025 467 1.86e-03 2 2 1 0.500 0.500 GO:0097211 BP 1 cellular response to gonadotropin-releasing hormone 1 P24387 467 1.86e-03 2 2 1 0.500 0.500 GO:0048149 BP 1 behavioral response to ethanol 1 P24387 467 1.86e-03 2 2 1 0.500 0.500 GO:0097210 BP 1 response to gonadotropin-releasing hormone 1 P24387 467 1.86e-03 2 2 1 0.500 0.500 GO:0035864 BP 1 response to potassium ion 1 P24387 467 1.86e-03 2 2 1 0.500 0.500 GO:0035865 BP 1 cellular response to potassium ion 1 P24387 467 2.01e-03 224 2 2 1.000 0.009 GO:0006954 BP 1 inflammatory response 1 P24387,Q15025 467 2.78e-03 3 2 1 0.500 0.333 GO:0031045 CC 1 dense core granule 1 P24387 467 3.71e-03 4 2 1 0.500 0.250 GO:0042220 BP 1 response to cocaine 1 P24387 467 7.42e-03 8 2 1 0.500 0.125 GO:2000310 BP 1 regulation of N-methyl-D-aspartate selective glutamate receptor activity 1 P24387 467 8.35e-03 9 2 1 0.500 0.111 GO:0071391 BP 1 cellular response to estrogen stimulus 1 P24387 467 1.02e-02 11 2 1 0.500 0.091 GO:0017046 MF 1 peptide hormone binding 1 P24387 467 1.02e-02 11 2 1 0.500 0.091 GO:0005767 CC 1 secondary lysosome 1 P24387 467 1.02e-02 11 2 1 0.500 0.091 GO:0071392 BP 1 cellular response to estradiol stimulus 1 P24387 467 1.02e-02 11 2 1 0.500 0.091 GO:0060986 BP 1 endocrine hormone secretion 1 P24387 467 1.11e-02 12 2 1 0.500 0.083 GO:0044060 BP 1 regulation of endocrine process 1 P24387 467 1.11e-02 12 2 1 0.500 0.083 GO:0090278 BP 1 negative regulation of peptide hormone secretion 1 P24387 467 1.21e-02 13 2 1 0.500 0.077 GO:0002792 BP 1 negative regulation of peptide secretion 1 P24387 467 1.21e-02 13 2 1 0.500 0.077 GO:0045471 BP 1 response to ethanol 1 P24387 467 1.30e-02 14 2 1 0.500 0.071 GO:0051019 MF 1 mitogen-activated protein kinase binding 1 Q15025 467 1.39e-02 15 2 1 0.500 0.067 GO:0001963 BP 1 synaptic transmission, dopaminergic 1 P24387 467 1.39e-02 15 2 1 0.500 0.067 GO:0071312 BP 1 cellular response to alkaloid 1 P24387 467 1.48e-02 16 2 1 0.500 0.062 GO:0043204 CC 1 perikaryon 1 P24387 467 1.58e-02 17 2 1 0.500 0.059 GO:0005771 CC 1 multivesicular body 1 P24387 467 1.58e-02 17 2 1 0.500 0.059 GO:0032355 BP 1 response to estradiol 1 P24387 467 1.58e-02 17 2 1 0.500 0.059 GO:2000272 BP 1 negative regulation of receptor activity 1 P24387 467 1.58e-02 17 2 1 0.500 0.059 GO:1900449 BP 1 regulation of glutamate receptor signaling pathway 1 P24387 467 1.58e-02 17 2 1 0.500 0.059 GO:0099601 BP 1 regulation of neurotransmitter receptor activity 1 P24387 467 1.61e-02 1369 2 2 1.000 0.001 HPA:017010_03 hpa 1 heart muscle; myocytes[Uncertain,High] 1 P24387,Q15025 467 1.63e-02 637 2 2 1.000 0.003 GO:0009968 BP 1 negative regulation of signal transduction 1 P24387,Q15025 467 1.63e-02 1380 2 2 1.000 0.001 HPA:040020_01 hpa 1 soft tissue 2; chondrocytes[Uncertain,Low] 1 P24387,Q15025 467 1.67e-02 18 2 1 0.500 0.056 GO:0043627 BP 1 response to estrogen 1 P24387 467 1.70e-02 650 2 2 1.000 0.003 GO:0051704 BP 1 multi-organism process 1 P24387,Q15025 467 1.76e-02 661 2 2 1.000 0.003 GO:0010648 BP 1 negative regulation of cell communication 1 P24387,Q15025 467 1.76e-02 19 2 1 0.500 0.053 GO:0071320 BP 1 cellular response to cAMP 1 P24387 467 1.76e-02 19 2 1 0.500 0.053 GO:0046888 BP 1 negative regulation of hormone secretion 1 P24387 467 1.76e-02 19 2 1 0.500 0.053 GO:0071242 BP 1 cellular response to ammonium ion 1 P24387 467 1.78e-02 665 2 2 1.000 0.003 GO:0023057 BP 1 negative regulation of signaling 1 P24387,Q15025 467 1.78e-02 666 2 2 1.000 0.003 GO:0006952 BP 1 defense response 1 P24387,Q15025 467 2.04e-02 22 2 1 0.500 0.045 GO:0043679 CC 1 axon terminus 1 P24387 467 2.04e-02 22 2 1 0.500 0.045 GO:0044068 BP 1 modulation by symbiont of host cellular process 1 Q15025 467 2.13e-02 23 2 1 0.500 0.043 GO:0060359 BP 1 response to ammonium ion 1 P24387 467 2.23e-02 24 2 1 0.500 0.042 GO:0035690 BP 1 cellular response to drug 1 P24387 467 2.23e-02 24 2 1 0.500 0.042 GO:0044304 CC 1 main axon 1 P24387 467 2.23e-02 24 2 1 0.500 0.042 GO:0002755 BP 1 MyD88-dependent toll-like receptor signaling pathway 1 Q15025 467 2.41e-02 26 2 1 0.500 0.038 GO:0050886 BP 1 endocrine process 1 P24387 467 2.41e-02 26 2 1 0.500 0.038 GO:0071277 BP 1 cellular response to calcium ion 1 P24387 467 2.41e-02 26 2 1 0.500 0.038 GO:0051591 BP 1 response to cAMP 1 P24387 467 2.41e-02 775 2 2 1.000 0.003 GO:0048585 BP 1 negative regulation of response to stimulus 1 P24387,Q15025 467 2.50e-02 27 2 1 0.500 0.037 GO:0042562 MF 1 hormone binding 1 P24387 467 2.50e-02 27 2 1 0.500 0.037 GO:0030534 BP 1 adult behavior 1 P24387 467 2.60e-02 28 2 1 0.500 0.036 GO:0044306 CC 1 neuron projection terminus 1 P24387 467 2.60e-02 28 2 1 0.500 0.036 GO:0043279 BP 1 response to alkaloid 1 P24387 467 2.69e-02 29 2 1 0.500 0.034 GO:0097305 BP 1 response to alcohol 1 P24387 467 2.87e-02 31 2 1 0.500 0.032 GO:0045071 BP 1 negative regulation of viral genome replication 1 Q15025 467 2.90e-02 1838 2 2 1.000 0.001 HPA:040020 hpa 1 soft tissue 2; chondrocytes 1 P24387,Q15025 467 2.97e-02 32 2 1 0.500 0.031 GO:0070373 BP 1 negative regulation of ERK1 and ERK2 cascade 1 Q15025 467 3.34e-02 36 2 1 0.500 0.028 GO:0044003 BP 1 modification by symbiont of host morphology or physiology 1 Q15025 467 3.43e-02 37 2 1 0.500 0.027 GO:0043124 BP 1 negative regulation of I-kappaB kinase/NF-kappaB signaling 1 Q15025 467 3.43e-02 37 2 1 0.500 0.027 GO:0007565 BP 1 female pregnancy 1 P24387 467 3.52e-02 38 2 1 0.500 0.026 GO:0050729 BP 1 positive regulation of inflammatory response 1 Q15025 467 3.63e-02 205 2 1 0.500 0.005 MI:hsa-miR-340* mi 1 MI:hsa-miR-340* 1 Q15025 467 3.75e-02 6 2 1 0.500 0.167 TF:M05931_0 tf 1 Factor: ZNF556; motif: NGATCGGTCCGC; match class: 0 1 P24387 467 3.80e-02 41 2 1 0.500 0.024 GO:0044706 BP 1 multi-multicellular organism process 1 P24387 467 3.89e-02 42 2 1 0.500 0.024 GO:0046683 BP 1 response to organophosphorus 1 P24387 467 4.08e-02 44 2 1 0.500 0.023 GO:0007215 BP 1 glutamate receptor signaling pathway 1 P24387 467 4.08e-02 44 2 1 0.500 0.023 GO:0014074 BP 1 response to purine-containing compound 1 P24387 467 4.17e-02 45 2 1 0.500 0.022 GO:0071248 BP 1 cellular response to metal ion 1 P24387 467 4.35e-02 47 2 1 0.500 0.021 GO:0007270 BP 1 neuron-neuron synaptic transmission 1 P24387 467 4.45e-02 48 2 1 0.500 0.021 GO:0033267 CC 1 axon part 1 P24387 467 4.87e-02 276 2 1 0.500 0.004 MI:hsa-miR-96* mi 1 MI:hsa-miR-96* 1 P24387 467 4.90e-02 278 2 1 0.500 0.004 MI:hsa-miR-550* mi 1 MI:hsa-miR-550* 1 P24387 467 5.00e-02 11 2 1 0.500 0.091 CORUM:5230 cor 1 CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex 1 Q15025 467 5.00e-02 54 2 1 0.500 0.019 GO:0045069 BP 1 regulation of viral genome replication 1 Q15025 467 5.00e-02 54 2 1 0.500 0.019 GO:0051592 BP 1 response to calcium ion 1 P24387 468 5.52e-25 14 8 8 1.000 0.571 GO:0000176 CC 1 nuclear exosome (RNase complex) 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.01e-23 23 8 8 1.000 0.348 GO:0000178 CC 1 exosome (RNase complex) 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.01e-23 23 8 8 1.000 0.348 GO:1905354 CC 1 exoribonuclease complex 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.10e-14 32 8 6 0.750 0.188 GO:0004532 MF 1 exoribonuclease activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.04e-14 229 8 8 1.000 0.035 GO:0006364 BP 1 rRNA processing 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.38e-14 232 8 8 1.000 0.034 GO:0016072 BP 1 rRNA metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.37e-14 14 8 5 0.625 0.357 GO:0016075 BP 1 rRNA catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q5RKV6 468 1.41e-13 15 8 5 0.625 0.333 GO:0000177 CC 1 cytoplasmic exosome (RNase complex) 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q5RKV6 468 1.47e-13 278 8 8 1.000 0.029 GO:0042254 BP 1 ribosome biogenesis 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.03e-13 348 8 8 1.000 0.023 GO:0034470 BP 1 ncRNA processing 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.51e-13 21 8 5 0.625 0.238 GO:0034661 BP 1 ncRNA catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q5RKV6 468 9.99e-13 65 8 6 0.750 0.092 GO:0004527 MF 1 exonuclease activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.46e-12 394 8 8 1.000 0.020 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 2.64e-12 76 8 6 0.750 0.079 GO:0004540 MF 1 ribonuclease activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 5.54e-12 29 8 5 0.625 0.172 GO:0043928 BP 1 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 7.93e-12 31 8 5 0.625 0.161 GO:0000291 BP 1 nuclear-transcribed mRNA catabolic process, exonucleolytic 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 9.45e-12 8 8 4 0.500 0.500 GO:0034427 BP 1 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 9.45e-12 8 8 4 0.500 0.500 GO:0034475 BP 1 U4 snRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 1.48e-11 492 8 8 1.000 0.016 GO:0034660 BP 1 ncRNA metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.86e-11 16 8 5 0.625 0.312 REAC:429958 rea 1 mRNA decay by 3' to 5' exoribonuclease 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 1.86e-11 16 8 5 0.625 0.312 REAC:450513 rea 1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.63e-11 17 8 5 0.625 0.294 REAC:450604 rea 1 KSRP (KHSRP) binds and destabilizes mRNA 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.63e-11 17 8 5 0.625 0.294 REAC:450385 rea 1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 4.45e-11 11 8 4 0.500 0.364 GO:0034472 BP 1 snRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 6.68e-11 12 8 4 0.500 0.333 GO:0071028 BP 1 nuclear mRNA surveillance 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 6.68e-11 12 8 4 0.500 0.333 GO:0071027 BP 1 nuclear RNA surveillance 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 8.63e-11 21 8 5 0.625 0.238 REAC:380994 rea 1 ATF4 activates genes 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 9.64e-11 13 8 4 0.500 0.308 GO:0031125 BP 1 rRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 9.64e-11 13 8 4 0.500 0.308 GO:0071025 BP 1 RNA surveillance 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 1.78e-10 151 8 6 0.750 0.040 GO:0004518 MF 1 nuclease activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 1.80e-10 24 8 5 0.625 0.208 REAC:381042 rea 1 PERK regulates gene expression 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.76e-10 61 8 5 0.625 0.082 GO:0000288 BP 1 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 3.78e-10 10 8 5 0.625 0.500 CORUM:788 cor 1 Exosome 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 4.49e-10 752 8 8 1.000 0.011 GO:0006396 BP 1 RNA processing 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 6.92e-10 11 8 5 0.625 0.455 CORUM:789 cor 1 Exosome 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 8.05e-10 21 8 4 0.500 0.190 GO:0043628 BP 1 ncRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 9.48e-10 199 8 6 0.750 0.030 GO:0006402 BP 1 mRNA catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 9.84e-10 22 8 4 0.500 0.182 GO:0016180 BP 1 snRNA processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 1.09e-09 200 8 7 0.875 0.035 REAC:72312 rea 1 rRNA processing 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q9Y3B2,Q13901,Q5RKV6 468 1.60e-09 217 8 6 0.750 0.028 GO:0006401 BP 1 RNA catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.12e-09 5 8 3 0.375 0.600 GO:0071051 BP 1 polyadenylation-dependent snoRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q5RKV6 468 3.68e-09 30 8 4 0.500 0.133 GO:0000460 BP 1 maturation of 5.8S rRNA 1 Q9NQT5,Q96B26,Q99547,Q13901 468 5.75e-09 1033 8 8 1.000 0.008 GO:1902494 CC 1 catalytic complex 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 6.23e-09 6 8 3 0.375 0.500 GO:0045006 BP 1 DNA deamination 1 Q9NQT4,Q9NQT5,Q5RKV6 468 9.88e-09 123 8 5 0.625 0.041 GO:0043488 BP 1 regulation of mRNA stability 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 1.09e-08 7 8 3 0.375 0.429 GO:0031126 BP 1 snoRNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q5RKV6 468 1.21e-08 128 8 5 0.625 0.039 GO:0043487 BP 1 regulation of RNA stability 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 1.22e-08 304 8 6 0.750 0.020 GO:0034655 BP 1 nucleobase-containing compound catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 1.33e-08 54 8 5 0.625 0.093 REAC:429914 rea 1 Deadenylation-dependent mRNA decay 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.14e-08 334 8 6 0.750 0.018 GO:0046700 BP 1 heterocycle catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.22e-08 336 8 6 0.750 0.018 GO:0044270 BP 1 cellular nitrogen compound catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.38e-08 340 8 6 0.750 0.018 GO:0019439 BP 1 aromatic compound catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.61e-08 9 8 3 0.375 0.333 GO:0043144 BP 1 snoRNA processing 1 Q9NQT4,Q9NQT5,Q5RKV6 468 3.19e-08 357 8 6 0.750 0.017 GO:1901361 BP 1 organic cyclic compound catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.73e-08 10 8 3 0.375 0.300 GO:0016074 BP 1 snoRNA metabolic process 1 Q9NQT4,Q9NQT5,Q5RKV6 468 8.36e-08 188 8 5 0.625 0.027 GO:0000956 BP 1 nuclear-transcribed mRNA catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 8.78e-08 78 8 5 0.625 0.064 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 1.21e-07 83 8 5 0.625 0.060 REAC:450531 rea 1 Regulation of mRNA stability by proteins that bind AU-rich elements 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.50e-07 504 8 6 0.750 0.012 GO:0016788 MF 1 hydrolase activity, acting on ester bonds 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.55e-07 84 8 4 0.500 0.048 GO:0016073 BP 1 snRNA metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 3.08e-07 522 8 6 0.750 0.011 GO:0016071 BP 1 mRNA metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 7.31e-07 109 8 4 0.500 0.037 GO:0031123 BP 1 RNA 3'-end processing 1 Q9NQT4,Q9NQT5,Q96B26,Q5RKV6 468 8.05e-07 26 8 3 0.375 0.115 GO:0000175 MF 1 3'-5'-exoribonuclease activity 1 Q9NQT4,Q9NQT5,Q8TF46 468 8.71e-07 1932 8 8 1.000 0.004 GO:0044085 BP 1 cellular component biogenesis 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.05e-07 27 8 3 0.375 0.111 GO:0016896 MF 1 exoribonuclease activity, producing 5'-phosphomonoesters 1 Q9NQT4,Q9NQT5,Q8TF46 468 1.08e-06 645 8 6 0.750 0.009 GO:0005730 CC 1 nucleolus 1 Q9NQT4,Q9NQT5,Q99547,Q9Y3B2,Q13901,Q5RKV6 468 1.15e-06 318 8 5 0.625 0.016 GO:0010608 BP 1 posttranscriptional regulation of gene expression 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 2.20e-06 727 8 6 0.750 0.008 GO:0044265 BP 1 cellular macromolecule catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.28e-06 41 8 3 0.375 0.073 GO:0016796 MF 1 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1 Q9NQT4,Q9NQT5,Q8TF46 468 4.08e-06 44 8 3 0.375 0.068 GO:0008408 MF 1 3'-5' exonuclease activity 1 Q9NQT4,Q9NQT5,Q8TF46 468 5.99e-06 5 8 2 0.250 0.400 GO:0071038 BP 1 nuclear polyadenylation-dependent tRNA catabolic process 1 Q9NQT5,Q96B26 468 6.59e-06 876 8 6 0.750 0.007 GO:0009057 BP 1 macromolecule catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 8.98e-06 6 8 2 0.250 0.333 GO:0016078 BP 1 tRNA catabolic process 1 Q9NQT5,Q96B26 468 8.98e-06 6 8 2 0.250 0.333 GO:0071035 BP 1 nuclear polyadenylation-dependent rRNA catabolic process 1 Q9NQT5,Q96B26 468 8.98e-06 6 8 2 0.250 0.333 GO:0071029 BP 1 nuclear ncRNA surveillance 1 Q9NQT5,Q96B26 468 8.98e-06 6 8 2 0.250 0.333 GO:0071046 BP 1 nuclear polyadenylation-dependent ncRNA catabolic process 1 Q9NQT5,Q96B26 468 8.98e-06 6 8 2 0.250 0.333 GO:0043634 BP 1 polyadenylation-dependent ncRNA catabolic process 1 Q9NQT5,Q96B26 468 1.02e-05 2627 8 8 1.000 0.003 GO:0016070 BP 1 RNA metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.16e-05 62 8 3 0.375 0.048 GO:0006304 BP 1 DNA modification 1 Q9NQT4,Q9NQT5,Q5RKV6 468 1.26e-05 7 8 2 0.250 0.286 GO:0043633 BP 1 polyadenylation-dependent RNA catabolic process 1 Q9NQT5,Q96B26 468 1.68e-05 8 8 2 0.250 0.250 GO:0000467 BP 1 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q9NQT5,Q96B26 468 1.68e-05 8 8 2 0.250 0.250 GO:0000459 BP 1 exonucleolytic trimming involved in rRNA processing 1 Q9NQT5,Q96B26 468 2.15e-05 9 8 2 0.250 0.222 GO:0090503 BP 1 RNA phosphodiester bond hydrolysis, exonucleolytic 1 Q9NQT5,Q96B26 468 2.46e-05 2931 8 8 1.000 0.003 GO:0031981 CC 1 nuclear lumen 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.07e-05 3013 8 8 1.000 0.003 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.10e-05 1141 8 6 0.750 0.005 GO:0044248 BP 1 cellular catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.45e-05 3058 8 8 1.000 0.003 GO:0010467 BP 1 gene expression 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.93e-05 1960 8 7 0.875 0.004 GO:0043228 CC 1 non-membrane-bounded organelle 1 Q9NQT4,Q9NQT5,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.93e-05 1960 8 7 0.875 0.004 GO:0043232 CC 1 intracellular non-membrane-bounded organelle 1 Q9NQT4,Q9NQT5,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 4.58e-05 3168 8 8 1.000 0.003 GO:0044428 CC 1 nuclear part 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 4.66e-05 13 8 2 0.250 0.154 GO:0045190 BP 1 isotype switching 1 Q9NQT5,Q5RKV6 468 4.66e-05 13 8 2 0.250 0.154 GO:0002204 BP 1 somatic recombination of immunoglobulin genes involved in immune response 1 Q9NQT5,Q5RKV6 468 4.66e-05 13 8 2 0.250 0.154 GO:0002208 BP 1 somatic diversification of immunoglobulins involved in immune response 1 Q9NQT5,Q5RKV6 468 5.43e-05 14 8 2 0.250 0.143 GO:0016447 BP 1 somatic recombination of immunoglobulin gene segments 1 Q9NQT5,Q5RKV6 468 5.43e-05 14 8 2 0.250 0.143 GO:0002381 BP 1 immunoglobulin production involved in immunoglobulin mediated immune response 1 Q9NQT5,Q5RKV6 468 6.32e-05 1290 8 6 0.750 0.005 GO:1901575 BP 1 organic substance catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 7.16e-05 16 8 2 0.250 0.125 GO:0035327 CC 1 transcriptionally active chromatin 1 Q9NQT4,Q9NQT5 468 8.36e-05 3415 8 8 1.000 0.002 GO:0032991 CC 1 macromolecular complex 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 8.66e-05 1362 8 6 0.750 0.004 GO:0009056 BP 1 catabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 8.92e-05 3443 8 8 1.000 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.12e-05 18 8 2 0.250 0.111 GO:0000466 BP 1 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q9NQT5,Q96B26 468 9.12e-05 18 8 2 0.250 0.111 GO:0002312 BP 1 B cell activation involved in immune response 1 Q9NQT5,Q5RKV6 468 1.13e-04 20 8 2 0.250 0.100 GO:0016445 BP 1 somatic diversification of immunoglobulins 1 Q9NQT5,Q5RKV6 468 1.13e-04 20 8 2 0.250 0.100 GO:0002562 BP 1 somatic diversification of immune receptors via germline recombination within a single locus 1 Q9NQT5,Q5RKV6 468 1.13e-04 20 8 2 0.250 0.100 GO:0016444 BP 1 somatic cell DNA recombination 1 Q9NQT5,Q5RKV6 468 1.15e-04 3554 8 8 1.000 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.17e-04 3561 8 8 1.000 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.17e-04 3561 8 8 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.17e-04 3561 8 8 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.17e-04 3561 8 8 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.25e-04 21 8 2 0.250 0.095 GO:0000469 BP 1 cleavage involved in rRNA processing 1 Q9NQT5,Q96B26 468 1.51e-04 23 8 2 0.250 0.087 GO:0016064 BP 1 immunoglobulin mediated immune response 1 Q9NQT5,Q5RKV6 468 1.52e-04 3681 8 8 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.64e-04 24 8 2 0.250 0.083 GO:0019724 BP 1 B cell mediated immunity 1 Q9NQT5,Q5RKV6 468 1.78e-04 25 8 2 0.250 0.080 GO:0002377 BP 1 immunoglobulin production 1 Q9NQT5,Q5RKV6 468 1.93e-04 26 8 2 0.250 0.077 GO:0002200 BP 1 somatic diversification of immune receptors 1 Q9NQT5,Q5RKV6 468 2.23e-04 2529 8 7 0.875 0.003 GO:0005654 CC 1 nucleoplasm 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q9Y3B2,Q13901,Q5RKV6 468 2.25e-04 1607 8 6 0.750 0.004 GO:0016787 MF 1 hydrolase activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 2.67e-04 3948 8 8 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 3.04e-04 4013 8 8 1.000 0.002 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 4.95e-04 4264 8 8 1.000 0.002 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 6.65e-04 48 8 2 0.250 0.042 GO:0090501 BP 1 RNA phosphodiester bond hydrolysis 1 Q9NQT5,Q96B26 468 6.71e-04 4430 8 8 1.000 0.002 GO:0005634 CC 1 nucleus 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.39e-04 57 8 2 0.250 0.035 GO:0002285 BP 1 lymphocyte activation involved in immune response 1 Q9NQT5,Q5RKV6 468 9.72e-04 58 8 2 0.250 0.034 GO:0002440 BP 1 production of molecular mediator of immune response 1 Q9NQT5,Q5RKV6 468 1.22e-03 1336 8 5 0.625 0.004 GO:0003723 MF 1 RNA binding 1 Q9NQT5,Q96B26,Q9Y3B2,Q13901,Q5RKV6 468 1.26e-03 1485 8 7 0.875 0.005 REAC:74160 rea 1 Gene Expression 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q9Y3B2,Q13901,Q5RKV6 468 1.48e-03 317 8 3 0.375 0.009 GO:0002252 BP 1 immune effector process 1 Q9NQT4,Q9NQT5,Q5RKV6 468 1.50e-03 72 8 2 0.250 0.028 GO:0002460 BP 1 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1 Q9NQT5,Q5RKV6 468 1.71e-03 77 8 2 0.250 0.026 GO:0002449 BP 1 lymphocyte mediated immunity 1 Q9NQT5,Q5RKV6 468 1.74e-03 4990 8 8 1.000 0.002 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.97e-03 2 8 1 0.125 0.500 GO:0071049 BP 1 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription 1 Q9NQT5 468 1.97e-03 2 8 1 0.125 0.500 GO:0071031 BP 1 nuclear mRNA surveillance of mRNA 3'-end processing 1 Q9NQT5 468 2.03e-03 84 8 2 0.250 0.024 GO:0002366 BP 1 leukocyte activation involved in immune response 1 Q9NQT5,Q5RKV6 468 2.08e-03 85 8 2 0.250 0.024 GO:0002263 BP 1 cell activation involved in immune response 1 Q9NQT5,Q5RKV6 468 2.13e-03 86 8 2 0.250 0.023 GO:0042113 BP 1 B cell activation 1 Q9NQT5,Q5RKV6 468 2.59e-03 95 8 2 0.250 0.021 GO:0002250 BP 1 adaptive immune response 1 Q9NQT5,Q5RKV6 468 2.69e-03 5 8 2 0.250 0.400 HP:0006850 hp 1 Hypoplasia of the ventral pons 1 Q9NQT5,Q96B26 468 2.69e-03 5 8 2 0.250 0.400 HP:0200147 hp 1 Neuronal loss in basal ganglia 1 Q9NQT5,Q96B26 468 2.90e-03 5319 8 8 1.000 0.002 GO:0043170 BP 1 macromolecule metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 2.96e-03 3 8 1 0.125 0.333 GO:0034473 BP 1 U1 snRNA 3'-end processing 1 Q96B26 468 2.96e-03 3 8 1 0.125 0.333 GO:0034476 BP 1 U5 snRNA 3'-end processing 1 Q96B26 468 3.08e-03 510 8 3 0.375 0.006 TF:M01146_0 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 0 1 Q9NQT5,Q8TF46,Q9Y3B2 468 3.28e-03 107 8 2 0.250 0.019 GO:0002443 BP 1 leukocyte mediated immunity 1 Q9NQT5,Q5RKV6 468 3.84e-03 116 8 2 0.250 0.017 GO:0090305 BP 1 nucleic acid phosphodiester bond hydrolysis 1 Q9NQT5,Q96B26 468 3.95e-03 4 8 1 0.125 0.250 GO:0071042 BP 1 nuclear polyadenylation-dependent mRNA catabolic process 1 Q96B26 468 3.95e-03 4 8 1 0.125 0.250 GO:0071043 BP 1 CUT metabolic process 1 Q9NQT5 468 3.95e-03 4 8 1 0.125 0.250 GO:0071034 BP 1 CUT catabolic process 1 Q9NQT5 468 3.95e-03 4 8 1 0.125 0.250 GO:0071033 BP 1 nuclear retention of pre-mRNA at the site of transcription 1 Q9NQT5 468 3.95e-03 4 8 1 0.125 0.250 GO:0071047 BP 1 polyadenylation-dependent mRNA catabolic process 1 Q96B26 468 5.61e-03 186 8 2 0.250 0.011 TF:M00457_0 tf 1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 0 1 Q99547,Q8TF46 468 5.70e-03 5787 8 8 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 6.28e-03 149 8 2 0.250 0.013 GO:0006399 BP 1 tRNA metabolic process 1 Q9NQT5,Q96B26 468 6.45e-03 5877 8 8 1.000 0.001 GO:0044422 CC 1 organelle part 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 6.57e-03 1924 8 5 0.625 0.003 GO:0065008 BP 1 regulation of biological quality 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 7.22e-03 160 8 2 0.250 0.013 GO:0006310 BP 1 DNA recombination 1 Q9NQT5,Q5RKV6 468 8.08e-03 1452 8 4 0.500 0.003 TF:M01841_0 tf 1 Factor: ERR1; motif: MCNTGACCTTKRRNN; match class: 0 1 Q9NQT5,Q96B26,Q99547,Q5RKV6 468 9.02e-03 6128 8 8 1.000 0.001 GO:0044238 BP 1 primary metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 9.39e-03 15 8 1 0.125 0.067 TF:M06246_1 tf 1 Factor: ZNF177; motif: NRWTGAAGAGCA; match class: 1 1 Q9Y3B2 468 9.63e-03 9 8 2 0.250 0.222 HP:0012473 hp 1 Tongue atrophy 1 Q9NQT5,Q96B26 468 9.85e-03 10 8 1 0.125 0.100 GO:0008298 BP 1 intracellular mRNA localization 1 Q9NQT5 468 1.03e-02 7188 8 8 1.000 0.001 TF:M01307_0 tf 1 Factor: Oct3; motif: NATGCAANNN; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.05e-02 13 8 2 0.250 0.154 OMIM:607596 omi 1 Pontocerebellar Hypoplasia 1 Q9NQT5,Q96B26 468 1.05e-02 2136 8 5 0.625 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q9NQT5,Q96B26,Q9Y3B2,Q13901,Q5RKV6 468 1.12e-02 6299 8 8 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.13e-02 2173 8 5 0.625 0.002 GO:0010468 BP 1 regulation of gene expression 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 1.20e-02 10 8 2 0.250 0.200 HP:0006999 hp 1 Basal ganglia gliosis 1 Q9NQT5,Q96B26 468 1.25e-02 670 8 3 0.375 0.004 GO:0006259 BP 1 DNA metabolic process 1 Q9NQT4,Q9NQT5,Q5RKV6 468 1.25e-02 20 8 1 0.125 0.050 TF:M03951_1 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 1 1 Q96B26 468 1.25e-02 20 8 1 0.125 0.050 TF:M05783_0 tf 1 Factor: ZNF667; motif: KGGGSCATTATC; match class: 0 1 Q8TF46 468 1.33e-02 3938 8 6 0.750 0.002 TF:M00072_0 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q13901 468 1.36e-02 2706 8 5 0.625 0.002 TF:M01759_0 tf 1 Factor: AML2; motif: AACCRCAA; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q13901 468 1.36e-02 2706 8 5 0.625 0.002 TF:M01856_0 tf 1 Factor: AML3; motif: AACCACAN; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q13901 468 1.42e-02 6484 8 8 1.000 0.001 GO:0071704 BP 1 organic substance metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.48e-02 308 8 2 0.250 0.006 TF:M04168_1 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 1 Q96B26,Q9Y3B2 468 1.50e-02 24 8 1 0.125 0.042 TF:M06632_1 tf 1 Factor: ZNF717; motif: GGGAAAAAGA; match class: 1 1 Q9NQT4 468 1.56e-02 238 8 2 0.250 0.008 GO:0046649 BP 1 lymphocyte activation 1 Q9NQT5,Q5RKV6 468 1.56e-02 1746 8 4 0.500 0.002 TF:M00006_0 tf 1 Factor: MEF-2A; motif: CTCTAAAAATAACYCY; match class: 0 1 Q9NQT5,Q99547,Q8TF46,Q13901 468 1.62e-02 1765 8 4 0.500 0.002 TF:M02024_0 tf 1 Factor: mef-2A; motif: TATTTWWANM; match class: 0 1 Q96B26,Q8TF46,Q13901,Q5RKV6 468 1.68e-02 27 8 1 0.125 0.037 TF:M01146_1 tf 1 Factor: DMRT1; motif: TTGMTACAWTGTTKC; match class: 1 1 Q8TF46 468 1.72e-02 6642 8 8 1.000 0.001 GO:0008152 BP 1 metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.78e-02 6671 8 8 1.000 0.001 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.87e-02 19 8 1 0.125 0.053 GO:0017091 MF 1 AU-rich element binding 1 Q96B26 468 1.92e-02 7767 8 8 1.000 0.001 TF:M07386_1 tf 1 Factor: Lmx1; motif: RDNTAATT; match class: 1 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 1.93e-02 31 8 1 0.125 0.032 TF:M06248_0 tf 1 Factor: ZNF91; motif: NKGTGARAAAGM; match class: 0 1 Q9NQT5 468 1.99e-02 32 8 1 0.125 0.031 TF:M05757_0 tf 1 Factor: ZNF648; motif: NGKGGCAGAATS; match class: 0 1 Q99547 468 2.12e-02 34 8 1 0.125 0.029 TF:M06214_0 tf 1 Factor: ZNF33b; motif: GTWAAGCGGA; match class: 0 1 Q9NQT4 468 2.16e-02 375 8 2 0.250 0.005 TF:M04168_0 tf 1 Factor: CLOCK; motif: AACACGTGTN; match class: 0 1 Q96B26,Q9Y3B2 468 2.20e-02 285 8 2 0.250 0.007 GO:0045321 BP 1 leukocyte activation 1 Q9NQT5,Q5RKV6 468 2.32e-02 293 8 2 0.250 0.007 GO:0002520 BP 1 immune system development 1 Q9NQT5,Q5RKV6 468 2.33e-02 391 8 2 0.250 0.005 TF:M01234_0 tf 1 Factor: ipf1; motif: AVCTAATGAG; match class: 0 1 Q8TF46,Q13901 468 2.33e-02 294 8 2 0.250 0.007 GO:0000785 CC 1 chromatin 1 Q9NQT4,Q9NQT5 468 2.37e-02 394 8 2 0.250 0.005 TF:M00416_0 tf 1 Factor: Cart-1; motif: NNNTAATTNNCATTANCN; match class: 0 1 Q9NQT5,Q96B26 468 2.53e-02 408 8 2 0.250 0.005 TF:M02002_0 tf 1 Factor: Evi-1; motif: TATCTTGTC; match class: 0 1 Q9NQT5,Q99547 468 2.54e-02 409 8 2 0.250 0.005 TF:M00731_1 tf 1 Factor: Osf2; motif: ACCACANM; match class: 1 1 Q9NQT5,Q13901 468 2.54e-02 2612 8 5 0.625 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q9NQT5,Q96B26,Q9Y3B2,Q13901,Q5RKV6 468 2.75e-02 2660 8 5 0.625 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 Q9NQT5,Q96B26,Q9Y3B2,Q13901,Q5RKV6 468 2.79e-02 45 8 1 0.125 0.022 TF:M07090_0 tf 1 Factor: c-Fos; motif: NNTGASTCATN; match class: 0 1 Q8TF46 468 2.81e-02 432 8 2 0.250 0.005 TF:M04184_1 tf 1 Factor: NHLH1; motif: CGCAGCTGCK; match class: 1 1 Q99547,Q5RKV6 468 2.92e-02 47 8 1 0.125 0.021 TF:M00001_1 tf 1 Factor: MyoD; motif: SRACAGGTGKYG; match class: 1 1 Q9NQT5 468 2.96e-02 2707 8 5 0.625 0.002 GO:0005829 CC 1 cytosol 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 3.02e-02 449 8 2 0.250 0.004 TF:M03866_1 tf 1 Factor: c-Fos:c-Jun; motif: NTGACTCAN; match class: 1 1 Q96B26,Q99547 468 3.11e-02 3282 8 5 0.625 0.002 TF:M07326_0 tf 1 Factor: Mef-2A; motif: YTATWTTTARNNC; match class: 0 1 Q96B26,Q99547,Q8TF46,Q13901,Q5RKV6 468 3.20e-02 1191 8 3 0.375 0.003 TF:M00155_1 tf 1 Factor: ARP-1; motif: TGARCCYTTGAMCCCW; match class: 1 1 Q9NQT4,Q9Y3B2,Q5RKV6 468 3.22e-02 52 8 1 0.125 0.019 TF:M05601_0 tf 1 Factor: FIZ1; motif: GGGSTMGGCCT; match class: 0 1 Q96B26 468 3.25e-02 418 8 3 0.375 0.007 MI:hsa-miR-568 mi 1 MI:hsa-miR-568 1 Q96B26,Q99547,Q13901 468 3.28e-02 419 8 3 0.375 0.007 MI:hsa-miR-192 mi 1 MI:hsa-miR-192 1 Q96B26,Q8TF46,Q13901 468 3.43e-02 481 8 2 0.250 0.004 TF:M01272_0 tf 1 Factor: SOX2; motif: NNNNCCWTTGTTWTKN; match class: 0 1 Q99547,Q13901 468 3.47e-02 56 8 1 0.125 0.018 TF:M05881_0 tf 1 Factor: ZNF676; motif: NGATTTGGGTGA; match class: 0 1 Q9Y3B2 468 3.47e-02 56 8 1 0.125 0.018 TF:M03951_0 tf 1 Factor: CDP; motif: ATCGATNNNNNNATCRAT; match class: 0 1 Q96B26 468 3.52e-02 4019 8 6 0.750 0.001 GO:0003824 MF 1 catalytic activity 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q9Y3B2,Q5RKV6 468 3.68e-02 3418 8 5 0.625 0.001 TF:M00341_1 tf 1 Factor: GABP; motif: VCCGGAAGNGCR; match class: 1 1 Q9NQT5,Q99547,Q9Y3B2,Q13901,Q5RKV6 468 3.69e-02 2242 8 4 0.500 0.002 TF:M07350_0 tf 1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 0 1 Q9NQT4,Q9Y3B2,Q13901,Q5RKV6 468 3.88e-02 3461 8 5 0.625 0.001 TF:M00342_0 tf 1 Factor: Oct-1; motif: TATGCAAATN; match class: 0 1 Q9NQT4,Q9NQT5,Q8TF46,Q13901,Q5RKV6 468 3.88e-02 385 8 2 0.250 0.005 GO:0001775 BP 1 cell activation 1 Q9NQT5,Q5RKV6 468 3.90e-02 516 8 2 0.250 0.004 TF:M07035_1 tf 1 Factor: Beta-catenin; motif: GNNNNCTTTGWTGNY; match class: 1 1 Q9Y3B2,Q13901 468 3.94e-02 447 8 3 0.375 0.007 MI:hsa-miR-587 mi 1 MI:hsa-miR-587 1 Q9NQT4,Q8TF46,Q9Y3B2 468 3.97e-02 1294 8 3 0.375 0.002 TF:M05464_0 tf 1 Factor: Sall1; motif: NAKKCGKAAAKG; match class: 0 1 Q9NQT5,Q9Y3B2,Q5RKV6 468 4.02e-02 450 8 3 0.375 0.007 MI:hsa-miR-215 mi 1 MI:hsa-miR-215 1 Q96B26,Q8TF46,Q13901 468 4.03e-02 525 8 2 0.250 0.004 TF:M07357_0 tf 1 Factor: HNF-6; motif: RNNWAAATCAATAAN; match class: 0 1 Q96B26,Q5RKV6 468 4.14e-02 67 8 1 0.125 0.015 TF:M05694_0 tf 1 Factor: ZNF80; motif: KGGGGCGACYGA; match class: 0 1 Q99547 468 4.21e-02 456 8 2 0.250 0.004 HPA:040020_11 hpa 1 soft tissue 2; chondrocytes[Supportive,Low] 1 Q9NQT5,Q99547 468 4.22e-02 6555 8 7 0.875 0.001 TF:M07390_0 tf 1 Factor: Nfe2l1; motif: TGYNNAGTCATT; match class: 0 1 Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 4.46e-02 3580 8 5 0.625 0.001 TF:M01151_0 tf 1 Factor: DMRT7; motif: TTGTTACAWTKTKG; match class: 0 1 Q9NQT4,Q9NQT5,Q96B26,Q8TF46,Q13901 468 4.48e-02 416 8 2 0.250 0.005 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 Q9NQT5,Q96B26 468 4.53e-02 4237 8 6 0.750 0.001 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901 468 4.63e-02 7517 8 8 1.000 0.001 GO:0043229 CC 1 intracellular organelle 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 4.68e-02 76 8 1 0.125 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q9NQT4 468 4.80e-02 78 8 1 0.125 0.013 TF:M05949_0 tf 1 Factor: ZNF714; motif: NGGGAAGGAAGM; match class: 0 1 Q99547 468 4.82e-02 1395 8 3 0.375 0.002 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q99547,Q8TF46,Q5RKV6 468 4.88e-02 5071 8 6 0.750 0.001 TF:M07391_0 tf 1 Factor: NKX2B; motif: ANNCACTTNA; match class: 0 1 Q9NQT4,Q96B26,Q99547,Q8TF46,Q13901,Q5RKV6 468 5.00e-02 1 8 1 0.125 1.000 OMIM:616081 omi 1 PONTOCEREBELLAR HYPOPLASIA, TYPE 1C; PCH1C;;HYPOMYELINATION WITH SPINAL MUSCULAR ATROPHY AND CEREBELLAR HYPOPLASIA 1 Q96B26 468 5.00e-02 1 8 1 0.125 1.000 CORUM:2004 cor 1 C1D homodimer protein 1 Q13901 468 5.00e-02 71 8 8 1.000 0.113 KEGG:03018 keg 1 RNA degradation 1 Q9NQT4,Q9NQT5,Q96B26,Q99547,Q8TF46,Q9Y3B2,Q13901,Q5RKV6 468 5.00e-02 1169 8 5 0.625 0.004 REAC:392499 rea 1 Metabolism of proteins 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 5.00e-02 486 8 3 0.375 0.006 MI:mmu-miR-465c-5p mi 1 MI:mmu-miR-465c-5p 1 Q9NQT5,Q96B26,Q13901 468 5.00e-02 3063 8 5 0.625 0.002 GO:0060255 BP 1 regulation of macromolecule metabolic process 1 Q9NQT4,Q9NQT5,Q96B26,Q9Y3B2,Q5RKV6 468 5.00e-02 1 8 1 0.125 1.000 OMIM:614678 omi 1 PONTOCEREBELLAR HYPOPLASIA, TYPE 1B; PCH1B 1 Q9NQT5 469 6.47e-04 275 2 2 1.000 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 P50395,Q9H0U4 469 3.65e-03 653 2 2 1.000 0.003 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 P50395,Q9H0U4 469 5.46e-03 798 2 2 1.000 0.003 HPA:007040_12 hpa 1 cerebral cortex; neuropil[Supportive,Medium] 1 P50395,Q9H0U4 469 7.37e-03 927 2 2 1.000 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 P50395,Q9H0U4 469 1.32e-02 1242 2 2 1.000 0.002 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 P50395,Q9H0U4 469 1.43e-02 1291 2 2 1.000 0.002 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 P50395,Q9H0U4 469 1.53e-02 1337 2 2 1.000 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P50395,Q9H0U4 469 1.81e-02 1453 2 2 1.000 0.001 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P50395,Q9H0U4 469 1.87e-02 1477 2 2 1.000 0.001 HPA:007040_11 hpa 1 cerebral cortex; neuropil[Supportive,Low] 1 P50395,Q9H0U4 469 2.17e-02 1589 2 2 1.000 0.001 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P50395,Q9H0U4 469 2.25e-02 1619 2 2 1.000 0.001 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P50395,Q9H0U4 469 2.25e-02 1621 2 2 1.000 0.001 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P50395,Q9H0U4 469 2.79e-02 1802 2 2 1.000 0.001 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 P50395,Q9H0U4 469 2.79e-02 1803 2 2 1.000 0.001 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P50395,Q9H0U4 469 2.96e-02 1857 2 2 1.000 0.001 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 2.98e-02 1863 2 2 1.000 0.001 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.05e-02 1885 2 2 1.000 0.001 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 P50395,Q9H0U4 469 3.18e-02 1924 2 2 1.000 0.001 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.20e-02 1932 2 2 1.000 0.001 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P50395,Q9H0U4 469 3.20e-02 1932 2 2 1.000 0.001 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.36e-02 14 2 1 0.500 0.071 REAC:162658 rea 1 Golgi Cisternae Pericentriolar Stack Reorganization 1 Q9H0U4 469 3.39e-02 1989 2 2 1.000 0.001 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P50395,Q9H0U4 469 3.40e-02 1990 2 2 1.000 0.001 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.51e-02 2024 2 2 1.000 0.001 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P50395,Q9H0U4 469 3.57e-02 2039 2 2 1.000 0.001 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P50395,Q9H0U4 469 3.58e-02 2043 2 2 1.000 0.001 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.60e-02 2049 2 2 1.000 0.001 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P50395,Q9H0U4 469 3.61e-02 2051 2 2 1.000 0.001 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.62e-02 2055 2 2 1.000 0.001 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 3.68e-02 2072 2 2 1.000 0.001 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P50395,Q9H0U4 469 3.75e-02 2092 2 2 1.000 0.001 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P50395,Q9H0U4 469 3.85e-02 2119 2 2 1.000 0.001 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P50395,Q9H0U4 469 3.92e-02 2139 2 2 1.000 0.001 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P50395,Q9H0U4 469 3.98e-02 2153 2 2 1.000 0.001 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.00e-02 2159 2 2 1.000 0.001 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.03e-02 2168 2 2 1.000 0.001 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.06e-02 2176 2 2 1.000 0.001 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.09e-02 2183 2 2 1.000 0.001 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.11e-02 2188 2 2 1.000 0.001 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.12e-02 2191 2 2 1.000 0.001 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.15e-02 2200 2 2 1.000 0.001 HPA:026010_10 hpa 1 ovary; follicle cells[Supportive,Not detected] 1 P50395,Q9H0U4 469 4.16e-02 2202 2 2 1.000 0.001 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P50395,Q9H0U4 469 4.19e-02 2209 2 2 1.000 0.001 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.21e-02 2215 2 2 1.000 0.001 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.25e-02 2227 2 2 1.000 0.001 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.25e-02 2227 2 2 1.000 0.001 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P50395,Q9H0U4 469 4.44e-02 2274 2 2 1.000 0.001 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.44e-02 2276 2 2 1.000 0.001 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.46e-02 2279 2 2 1.000 0.001 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.46e-02 2281 2 2 1.000 0.001 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.48e-02 2286 2 2 1.000 0.001 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.50e-02 2290 2 2 1.000 0.001 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.52e-02 2295 2 2 1.000 0.001 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.52e-02 522 2 2 1.000 0.004 REAC:199991 rea 1 Membrane Trafficking 1 P50395,Q9H0U4 469 4.57e-02 2308 2 2 1.000 0.001 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P50395,Q9H0U4 469 4.58e-02 2310 2 2 1.000 0.001 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.65e-02 2328 2 2 1.000 0.001 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.71e-02 2342 2 2 1.000 0.001 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.80e-02 2366 2 2 1.000 0.001 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.88e-02 2385 2 2 1.000 0.001 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.92e-02 2395 2 2 1.000 0.001 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P50395,Q9H0U4 469 4.93e-02 2397 2 2 1.000 0.001 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P50395,Q9H0U4 469 5.00e-02 1 2 1 0.500 1.000 TF:M03991_1 tf 1 Factor: SPDEF; motif: AMCCGGATGTN; match class: 1 1 Q9H0U4 469 5.00e-02 549 2 2 1.000 0.004 REAC:5653656 rea 1 Vesicle-mediated transport 1 P50395,Q9H0U4 469 5.00e-02 308 2 2 1.000 0.006 MI:hsa-miR-432* mi 1 MI:hsa-miR-432* 1 P50395,Q9H0U4 469 5.00e-02 2 2 1 0.500 0.500 GO:0005093 MF 1 Rab GDP-dissociation inhibitor activity 1 P50395 469 5.00e-02 42 2 1 0.500 0.024 KEGG:05134 keg 1 Legionellosis 1 Q9H0U4 470 1.98e-16 28 6 6 1.000 0.214 GO:0006294 BP 1 nucleotide-excision repair, preincision complex assembly 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.80e-15 11 6 5 0.833 0.455 GO:0005675 CC 1 holo TFIIH complex 1 P51948,P18074,P50613,P51946,P28715 470 2.66e-14 42 6 6 1.000 0.143 REAC:5696395 rea 1 Formation of Incision Complex in GG-NER 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 8.21e-14 72 6 6 1.000 0.083 GO:0006283 BP 1 transcription-coupled nucleotide-excision repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 9.39e-14 20 6 5 0.833 0.250 GO:0032806 CC 1 carboxy-terminal domain protein kinase complex 1 P51948,P18074,P50613,P51946,P28715 470 3.06e-13 89 6 6 1.000 0.067 GO:0090575 CC 1 RNA polymerase II transcription factor complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.75e-13 92 6 6 1.000 0.065 GO:0016591 CC 1 DNA-directed RNA polymerase II, holoenzyme 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.80e-13 64 6 6 1.000 0.094 REAC:6782135 rea 1 Dual incision in TC-NER 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.66e-13 101 6 6 1.000 0.059 GO:0044798 CC 1 nuclear transcription factor complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 7.19e-13 29 6 5 0.833 0.172 GO:0006362 BP 1 transcription elongation from RNA polymerase I promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 9.50e-13 107 6 6 1.000 0.056 GO:0006289 BP 1 nucleotide-excision repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.03e-12 31 6 5 0.833 0.161 GO:0006363 BP 1 termination of RNA polymerase I transcription 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.20e-12 77 6 6 1.000 0.078 REAC:6781827 rea 1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.22e-12 32 6 5 0.833 0.156 GO:0006370 BP 1 7-methylguanosine mRNA capping 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.40e-12 114 6 6 1.000 0.053 GO:0000428 CC 1 DNA-directed RNA polymerase complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.40e-12 114 6 6 1.000 0.053 GO:0055029 CC 1 nuclear DNA-directed RNA polymerase complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.44e-12 33 6 5 0.833 0.152 GO:0006361 BP 1 transcription initiation from RNA polymerase I promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.56e-12 116 6 6 1.000 0.052 GO:0030880 CC 1 RNA polymerase complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.68e-12 34 6 5 0.833 0.147 GO:0009452 BP 1 7-methylguanosine RNA capping 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.91e-12 83 6 6 1.000 0.072 REAC:5696399 rea 1 Global Genome Nucleotide Excision Repair (GG-NER) 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.96e-12 35 6 5 0.833 0.143 GO:0036260 BP 1 RNA capping 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.34e-12 45 6 6 1.000 0.133 KEGG:03420 keg 1 Nucleotide excision repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.95e-12 27 6 5 0.833 0.185 REAC:77075 rea 1 RNA Pol II CTD phosphorylation and interaction with CE 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.77e-12 134 6 6 1.000 0.045 GO:0065004 BP 1 protein-DNA complex assembly 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.22e-12 10 6 5 0.833 0.500 CORUM:1029 cor 1 TFIIH transcription factor complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.22e-12 10 6 5 0.833 0.500 CORUM:1009 cor 1 TFIIH transcription factor complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.33e-12 29 6 5 0.833 0.172 REAC:72086 rea 1 mRNA Capping 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 5.20e-12 30 6 5 0.833 0.167 REAC:73772 rea 1 RNA Polymerase I Promoter Escape 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 6.20e-12 31 6 5 0.833 0.161 REAC:73863 rea 1 RNA Polymerase I Transcription Termination 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 7.35e-12 32 6 5 0.833 0.156 REAC:167158 rea 1 Formation of the HIV-1 Early Elongation Complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 7.35e-12 32 6 5 0.833 0.156 REAC:113418 rea 1 Formation of the Early Elongation Complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 9.93e-12 157 6 6 1.000 0.038 GO:0071824 BP 1 protein-DNA complex subunit organization 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.03e-11 109 6 6 1.000 0.055 REAC:5696398 rea 1 Nucleotide Excision Repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.42e-11 51 6 5 0.833 0.098 GO:0006360 BP 1 transcription from RNA polymerase I promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.50e-11 168 6 6 1.000 0.036 GO:0005667 CC 1 transcription factor complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.93e-11 4 6 4 0.667 1.000 CORUM:1030 cor 1 CAK-ERCC2 complex 1 P51948,P18074,P50613,P51946 470 1.93e-11 4 6 4 0.667 1.000 CORUM:2660 cor 1 ERCC2/CAK complex 1 P51948,P18074,P50613,P51946 470 3.51e-11 43 6 5 0.833 0.116 REAC:167169 rea 1 HIV Transcription Elongation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.51e-11 43 6 5 0.833 0.116 REAC:167200 rea 1 Formation of HIV-1 elongation complex containing HIV-1 Tat 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.51e-11 43 6 5 0.833 0.116 REAC:167246 rea 1 Tat-mediated elongation of the HIV-1 transcript 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.96e-11 44 6 5 0.833 0.114 REAC:73777 rea 1 RNA Polymerase I Chain Elongation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.96e-11 44 6 5 0.833 0.114 REAC:167152 rea 1 Formation of HIV elongation complex in the absence of HIV Tat 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.76e-11 15 6 4 0.667 0.267 GO:0008353 MF 1 RNA polymerase II carboxy-terminal domain kinase activity 1 P51948,P18074,P50613,P51946 470 4.99e-11 46 6 5 0.833 0.109 REAC:76042 rea 1 RNA Polymerase II Transcription Initiation And Promoter Clearance 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.99e-11 46 6 5 0.833 0.109 REAC:167162 rea 1 RNA Polymerase II HIV Promoter Escape 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.99e-11 46 6 5 0.833 0.109 REAC:73776 rea 1 RNA Polymerase II Promoter Escape 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.99e-11 46 6 5 0.833 0.109 REAC:73779 rea 1 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.99e-11 46 6 5 0.833 0.109 REAC:75953 rea 1 RNA Polymerase II Transcription Initiation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.99e-11 46 6 5 0.833 0.109 REAC:167161 rea 1 HIV Transcription Initiation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 5.59e-11 47 6 5 0.833 0.106 REAC:73762 rea 1 RNA Polymerase I Transcription Initiation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 6.91e-11 216 6 6 1.000 0.028 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 7.30e-11 70 6 5 0.833 0.071 GO:1902554 CC 1 serine/threonine protein kinase complex 1 P51948,P18074,P50613,P51946,P28715 470 9.46e-11 52 6 5 0.833 0.096 REAC:6781823 rea 1 Formation of TC-NER Pre-Incision Complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.52e-10 57 6 5 0.833 0.088 REAC:112382 rea 1 Formation of RNA Pol II elongation complex 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.52e-10 57 6 5 0.833 0.088 REAC:75955 rea 1 RNA Polymerase II Transcription Elongation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.54e-10 81 6 5 0.833 0.062 GO:1902911 CC 1 protein kinase complex 1 P51948,P18074,P50613,P51946,P28715 470 1.99e-10 60 6 5 0.833 0.083 REAC:427413 rea 1 NoRC negatively regulates rRNA expression 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.99e-10 60 6 5 0.833 0.083 REAC:6796648 rea 1 TP53 Regulates Transcription of DNA Repair Genes 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.50e-10 89 6 5 0.833 0.056 GO:0006368 BP 1 transcription elongation from RNA polymerase II promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.56e-10 63 6 5 0.833 0.079 REAC:6782210 rea 1 Gap-filling DNA repair synthesis and ligation in TC-NER 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.56e-10 63 6 5 0.833 0.079 REAC:73854 rea 1 RNA Polymerase I Promoter Clearance 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.56e-10 63 6 5 0.833 0.079 REAC:5250941 rea 1 Negative epigenetic regulation of rRNA expression 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.00e-10 65 6 5 0.833 0.077 REAC:73864 rea 1 RNA Polymerase I Transcription 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.08e-10 69 6 5 0.833 0.072 REAC:167172 rea 1 Transcription of the HIV genome 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.31e-10 99 6 5 0.833 0.051 GO:0006353 BP 1 DNA-templated transcription, termination 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 8.18e-10 79 6 5 0.833 0.063 REAC:674695 rea 1 RNA Polymerase II Pre-transcription Events 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 9.23e-10 115 6 5 0.833 0.043 GO:0006354 BP 1 DNA-templated transcription, elongation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.39e-09 43 6 5 0.833 0.116 KEGG:03022 keg 1 Basal transcription factors 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.16e-09 136 6 5 0.833 0.037 GO:0006367 BP 1 transcription initiation from RNA polymerase II promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.25e-09 384 6 6 1.000 0.016 GO:0006281 BP 1 DNA repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.42e-09 9 6 4 0.667 0.444 CORUM:1036 cor 1 TFIIH transcription factor complex 1 P51948,P18074,P50613,P51946 470 2.42e-09 9 6 4 0.667 0.444 CORUM:107 cor 1 TFIIH transcription factor complex 1 P51948,P18074,P50613,P51946 470 2.46e-09 98 6 5 0.833 0.051 REAC:504046 rea 1 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.70e-09 272 6 6 1.000 0.022 REAC:73894 rea 1 DNA Repair 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.87e-09 101 6 5 0.833 0.050 REAC:212165 rea 1 Epigenetic regulation of gene expression 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 6.88e-09 171 6 5 0.833 0.029 GO:0006352 BP 1 DNA-templated transcription, initiation 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 9.93e-09 129 6 5 0.833 0.039 REAC:162599 rea 1 Late Phase of HIV Life Cycle 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.42e-08 521 6 6 1.000 0.012 GO:0044451 CC 1 nucleoplasm part 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.48e-08 3 6 3 0.500 1.000 CORUM:1010 cor 1 CAK complex (Cdk-activating kinase complex) 1 P51948,P50613,P51946 470 1.48e-08 3 6 3 0.500 1.000 CORUM:1008 cor 1 CAK complex (Cdk-activating kinase complex) 1 P51948,P50613,P51946 470 1.50e-08 140 6 5 0.833 0.036 REAC:162587 rea 1 HIV Life Cycle 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.50e-08 140 6 5 0.833 0.036 REAC:73857 rea 1 RNA Polymerase II Transcription 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.06e-08 592 6 6 1.000 0.010 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.36e-08 71 6 4 0.667 0.056 GO:0008094 MF 1 DNA-dependent ATPase activity 1 P51948,P18074,P50613,P51946 470 4.21e-08 624 6 6 1.000 0.010 GO:1990234 CC 1 transferase complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.46e-08 670 6 6 1.000 0.009 GO:0006259 BP 1 DNA metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 7.64e-08 689 6 6 1.000 0.009 GO:0034622 BP 1 cellular macromolecular complex assembly 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.43e-07 219 6 5 0.833 0.023 REAC:162906 rea 1 HIV Infection 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.47e-07 5 6 3 0.500 0.600 CORUM:2657 cor 1 ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex 1 P51948,P50613,P51946 470 1.78e-07 21 6 3 0.500 0.143 GO:0006293 BP 1 nucleotide-excision repair, preincision complex stabilization 1 P18074,P28715,Q6ZYL4 470 1.78e-07 21 6 3 0.500 0.143 GO:0006295 BP 1 nucleotide-excision repair, DNA incision, 3'-to lesion 1 P18074,P28715,Q6ZYL4 470 2.24e-07 342 6 5 0.833 0.015 GO:0006397 BP 1 mRNA processing 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.94e-07 6 6 3 0.500 0.500 CORUM:5495 cor 1 TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2) 1 P18074,P50613,P51946 470 4.87e-07 22 6 3 0.500 0.136 REAC:69273 rea 1 Cyclin A/B1 associated events during G2/M transition 1 P51948,P50613,P51946 470 8.74e-07 1033 6 6 1.000 0.006 GO:1902494 CC 1 catalytic complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 9.53e-07 36 6 3 0.500 0.083 GO:0006296 BP 1 nucleotide-excision repair, DNA incision, 5'-to lesion 1 P18074,P28715,Q6ZYL4 470 1.13e-06 38 6 3 0.500 0.079 GO:0033683 BP 1 nucleotide-excision repair, DNA incision 1 P18074,P28715,Q6ZYL4 470 1.13e-06 331 6 5 0.833 0.015 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.37e-06 1113 6 6 1.000 0.005 GO:0065003 BP 1 macromolecular complex assembly 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.41e-06 346 6 5 0.833 0.014 REAC:5663205 rea 1 Infectious disease 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.85e-06 522 6 5 0.833 0.010 GO:0016071 BP 1 mRNA metabolic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.29e-06 1212 6 6 1.000 0.005 GO:0033554 BP 1 cellular response to stress 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.45e-06 37 6 3 0.500 0.081 REAC:69236 rea 1 G1 Phase 1 P51948,P50613,P51946 470 2.45e-06 37 6 3 0.500 0.081 REAC:69231 rea 1 Cyclin D associated events in G1 1 P51948,P50613,P51946 470 3.11e-06 40 6 3 0.500 0.075 REAC:5696400 rea 1 Dual Incision in GG-NER 1 P18074,P28715,Q6ZYL4 470 3.87e-06 5 6 2 0.333 0.400 GO:0019907 CC 1 cyclin-dependent protein kinase activating kinase holoenzyme complex 1 P18074,P51946 470 5.02e-06 62 6 3 0.500 0.048 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 P51948,P50613,P51946 470 5.02e-06 62 6 3 0.500 0.048 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 P51948,P50613,P51946 470 6.36e-06 67 6 3 0.500 0.045 GO:0047485 MF 1 protein N-terminus binding 1 P51948,P18074,P28715 470 6.67e-06 264 6 4 0.667 0.015 GO:0042623 MF 1 ATPase activity, coupled 1 P51948,P18074,P50613,P51946 470 8.47e-06 2 6 2 0.333 1.000 CORUM:1007 cor 1 CAK core complex (Cdk-activating kinase core complex) 1 P50613,P51946 470 1.08e-05 8 6 2 0.333 0.250 GO:0009650 BP 1 UV protection 1 P18074,P28715 470 1.13e-05 752 6 5 0.833 0.007 GO:0006396 BP 1 RNA processing 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.28e-05 1614 6 6 1.000 0.004 GO:0043933 BP 1 macromolecular complex subunit organization 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.56e-05 68 6 3 0.500 0.044 REAC:69656 rea 1 Cyclin A:Cdk2-associated events at S phase entry 1 P51948,P50613,P51946 470 1.60e-05 329 6 4 0.667 0.012 GO:0004674 MF 1 protein serine/threonine kinase activity 1 P51948,P18074,P50613,P51946 470 1.63e-05 69 6 3 0.500 0.043 REAC:69202 rea 1 Cyclin E associated events during G1/S transition 1 P51948,P50613,P51946 470 1.78e-05 1706 6 6 1.000 0.004 GO:0022607 BP 1 cellular component assembly 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.14e-05 354 6 4 0.667 0.011 GO:0016887 MF 1 ATPase activity 1 P51948,P18074,P50613,P51946 470 2.72e-05 628 6 5 0.833 0.008 REAC:212436 rea 1 Generic Transcription Pathway 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.33e-05 116 6 3 0.500 0.026 GO:0090305 BP 1 nucleic acid phosphodiester bond hydrolysis 1 P18074,P28715,Q6ZYL4 470 3.52e-05 14 6 2 0.333 0.143 GO:0019908 CC 1 nuclear cyclin-dependent protein kinase holoenzyme complex 1 P18074,P51946 470 3.77e-05 1932 6 6 1.000 0.003 GO:0044085 BP 1 cellular component biogenesis 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.87e-05 411 6 4 0.667 0.010 GO:0044772 BP 1 mitotic cell cycle phase transition 1 P51948,P18074,P50613,P51946 470 4.41e-05 425 6 4 0.667 0.009 GO:0044770 BP 1 cell cycle phase transition 1 P51948,P18074,P50613,P51946 470 5.34e-05 720 6 5 0.833 0.007 REAC:1643685 rea 1 Disease 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 5.72e-05 2071 6 6 1.000 0.003 GO:0006950 BP 1 response to stress 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.15e-05 2096 6 6 1.000 0.003 GO:0043234 CC 1 protein complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.24e-05 143 6 3 0.500 0.021 GO:0031334 BP 1 positive regulation of protein complex assembly 1 P18074,P28715,Q6ZYL4 470 6.68e-05 472 6 4 0.667 0.008 GO:0004672 MF 1 protein kinase activity 1 P51948,P18074,P50613,P51946 470 7.59e-05 115 6 3 0.500 0.026 REAC:69206 rea 1 G1/S Transition 1 P51948,P50613,P51946 470 7.79e-05 154 6 3 0.500 0.019 GO:0000086 BP 1 G2/M transition of mitotic cell cycle 1 P51948,P50613,P51946 470 8.10e-05 21 6 2 0.333 0.095 GO:0000717 BP 1 nucleotide-excision repair, DNA duplex unwinding 1 P18074,Q6ZYL4 470 8.89e-05 161 6 3 0.500 0.019 GO:0044839 BP 1 cell cycle G2/M phase transition 1 P51948,P50613,P51946 470 9.49e-05 516 6 4 0.667 0.008 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 P51948,P18074,P50613,P51946 470 9.97e-05 126 6 3 0.500 0.024 REAC:69242 rea 1 S Phase 1 P51948,P50613,P51946 470 1.04e-04 1177 6 5 0.833 0.004 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.18e-04 4 6 2 0.333 0.500 OMIM:214150 omi 1 Cerebrooculofacioskeletal Syndrome 1 P18074,P28715 470 1.20e-04 178 6 3 0.500 0.017 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 P51948,P50613,P51946 470 1.25e-04 553 6 4 0.667 0.007 GO:0017111 MF 1 nucleoside-triphosphatase activity 1 P51948,P18074,P50613,P51946 470 1.31e-04 138 6 3 0.500 0.022 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 P51948,P50613,P51946 470 1.35e-04 185 6 3 0.500 0.016 GO:0044843 BP 1 cell cycle G1/S phase transition 1 P51948,P50613,P51946 470 1.48e-04 578 6 4 0.667 0.007 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 P51948,P18074,P50613,P51946 470 1.61e-04 590 6 4 0.667 0.007 GO:0016462 MF 1 pyrophosphatase activity 1 P51948,P18074,P50613,P51946 470 1.63e-04 592 6 4 0.667 0.007 GO:0016818 MF 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 P51948,P18074,P50613,P51946 470 1.63e-04 592 6 4 0.667 0.007 GO:0016817 MF 1 hydrolase activity, acting on acid anhydrides 1 P51948,P18074,P50613,P51946 470 1.67e-04 30 6 2 0.333 0.067 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 P18074,P51946 470 1.79e-04 31 6 2 0.333 0.065 GO:0070911 BP 1 global genome nucleotide-excision repair 1 P18074,Q6ZYL4 470 1.90e-04 2529 6 6 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.95e-04 4 6 2 0.333 0.500 HP:0004681 hp 1 Deep longitudinal plantar crease 1 P18074,P28715 470 1.95e-04 4 6 2 0.333 0.500 HP:0008125 hp 1 Second metatarsal posteriorly placed 1 P18074,P28715 470 1.96e-04 5 6 2 0.333 0.400 OMIM:601675 omi 1 Trichothiodystrophy 1 P18074,Q6ZYL4 470 2.08e-04 630 6 4 0.667 0.006 GO:0016301 MF 1 kinase activity 1 P51948,P18074,P50613,P51946 470 2.16e-04 34 6 2 0.333 0.059 GO:0005669 CC 1 transcription factor TFIID complex 1 P18074,Q6ZYL4 470 2.29e-04 35 6 2 0.333 0.057 GO:0032508 BP 1 DNA duplex unwinding 1 P18074,Q6ZYL4 470 2.45e-04 657 6 4 0.667 0.006 GO:1903047 BP 1 mitotic cell cycle process 1 P51948,P18074,P50613,P51946 470 2.47e-04 171 6 3 0.500 0.018 REAC:69275 rea 1 G2/M Transition 1 P51948,P50613,P51946 470 2.54e-04 229 6 3 0.500 0.013 GO:0043254 BP 1 regulation of protein complex assembly 1 P18074,P28715,Q6ZYL4 470 2.56e-04 173 6 3 0.500 0.017 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 P51948,P50613,P51946 470 2.79e-04 679 6 4 0.667 0.006 GO:0051726 BP 1 regulation of cell cycle 1 P51948,P18074,P50613,P51946 470 3.22e-04 2761 6 6 1.000 0.002 GO:0048522 BP 1 positive regulation of cellular process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.24e-04 5 6 2 0.333 0.400 HP:0045055 hp 1 Tiger tail banding 1 P18074,Q6ZYL4 470 3.24e-04 5 6 2 0.333 0.400 HP:0006313 hp 1 Widely spaced primary teeth 1 P18074,Q6ZYL4 470 3.24e-04 5 6 2 0.333 0.400 HP:0005458 hp 1 Premature closure of fontanelles 1 P18074,P28715 470 3.46e-04 43 6 2 0.333 0.047 GO:0032392 BP 1 DNA geometric change 1 P18074,Q6ZYL4 470 3.52e-04 721 6 4 0.667 0.006 GO:0000278 BP 1 mitotic cell cycle 1 P51948,P18074,P50613,P51946 470 3.87e-04 264 6 3 0.500 0.011 GO:0044089 BP 1 positive regulation of cellular component biogenesis 1 P18074,P28715,Q6ZYL4 470 3.92e-04 741 6 4 0.667 0.005 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 P51948,P18074,P50613,P51946 470 3.92e-04 741 6 4 0.667 0.005 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 P51948,P18074,P50613,P51946 470 4.22e-04 755 6 4 0.667 0.005 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 P51948,P18074,P50613,P51946 470 4.37e-04 762 6 4 0.667 0.005 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 P51948,P18074,P50613,P51946 470 4.41e-04 276 6 3 0.500 0.011 GO:0071900 BP 1 regulation of protein serine/threonine kinase activity 1 P51948,P50613,P51946 470 4.61e-04 2931 6 6 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.76e-04 1607 6 5 0.833 0.003 GO:0016787 MF 1 hydrolase activity 1 P51948,P18074,P50613,P51946,P28715 470 4.86e-04 6 6 2 0.333 0.333 HP:0007519 hp 1 Lack of subcutaneous fatty tissue 1 P18074,Q6ZYL4 470 5.06e-04 791 6 4 0.667 0.005 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 P51948,P18074,P50613,P51946 470 5.44e-04 3013 6 6 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 5.66e-04 3033 6 6 1.000 0.002 GO:0048518 BP 1 positive regulation of biological process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.45e-04 842 6 4 0.667 0.005 GO:0006461 BP 1 protein complex assembly 1 P51948,P18074,P28715,Q6ZYL4 470 6.45e-04 842 6 4 0.667 0.005 GO:0070271 BP 1 protein complex biogenesis 1 P51948,P18074,P28715,Q6ZYL4 470 7.35e-04 3168 6 6 1.000 0.002 GO:0044428 CC 1 nuclear part 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 8.21e-04 896 6 4 0.667 0.004 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 P51948,P18074,P50613,P51946 470 9.05e-04 8 6 2 0.333 0.250 HP:0009886 hp 1 Trichorrhexis nodosa 1 P18074,Q6ZYL4 470 9.05e-04 8 6 2 0.333 0.250 HP:0003079 hp 1 Defective DNA repair after ultraviolet radiation damage 1 P18074,P28715 470 9.17e-04 922 6 4 0.667 0.004 GO:0010628 BP 1 positive regulation of gene expression 1 P51948,P18074,P50613,P51946 470 9.60e-04 933 6 4 0.667 0.004 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 P51948,P18074,P50613,P51946 470 9.81e-04 1865 6 5 0.833 0.003 GO:0006351 BP 1 transcription, DNA-templated 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 9.99e-04 1872 6 5 0.833 0.003 GO:0097659 BP 1 nucleic acid-templated transcription 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.04e-03 952 6 4 0.667 0.004 GO:0022402 BP 1 cell cycle process 1 P51948,P18074,P50613,P51946 470 1.05e-03 2334 6 5 0.833 0.002 TF:M04403_1 tf 1 Factor: MNX1; motif: NNYAATTAAN; match class: 1 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.05e-03 956 6 4 0.667 0.004 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 P51948,P18074,P50613,P51946 470 1.12e-03 970 6 4 0.667 0.004 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 P51948,P18074,P50613,P51946 470 1.12e-03 971 6 4 0.667 0.004 GO:0009891 BP 1 positive regulation of biosynthetic process 1 P51948,P18074,P50613,P51946 470 1.15e-03 3415 6 6 1.000 0.002 GO:0032991 CC 1 macromolecular complex 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.21e-03 3443 6 6 1.000 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.22e-03 993 6 4 0.667 0.004 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 P51948,P18074,P50613,P51946 470 1.31e-03 1980 6 5 0.833 0.003 GO:0032774 BP 1 RNA biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.33e-03 1015 6 4 0.667 0.004 GO:0071822 BP 1 protein complex subunit organization 1 P51948,P18074,P28715,Q6ZYL4 470 1.33e-03 402 6 3 0.500 0.007 GO:0045859 BP 1 regulation of protein kinase activity 1 P51948,P50613,P51946 470 1.45e-03 10 6 2 0.333 0.200 HP:0005328 hp 1 Progeroid facial appearance 1 P18074,Q6ZYL4 470 1.47e-03 3554 6 6 1.000 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.48e-03 3561 6 6 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.48e-03 3561 6 6 1.000 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.48e-03 3561 6 6 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.48e-03 3561 6 6 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.50e-03 59 6 3 0.500 0.051 HP:0000992 hp 1 Cutaneous photosensitivity 1 P18074,P28715,Q6ZYL4 470 1.62e-03 93 6 2 0.333 0.022 GO:0009411 BP 1 response to UV 1 P18074,P28715 470 1.73e-03 439 6 3 0.500 0.007 GO:0043549 BP 1 regulation of kinase activity 1 P51948,P50613,P51946 470 1.81e-03 3681 6 6 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.81e-03 1485 6 5 0.833 0.003 REAC:74160 rea 1 Gene Expression 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.83e-03 2620 6 5 0.833 0.002 TF:M04430_0 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 0 1 P51948,P18074,P50613,P28715,Q6ZYL4 470 1.99e-03 1128 6 4 0.667 0.004 GO:0007049 BP 1 cell cycle 1 P51948,P18074,P50613,P51946 470 2.04e-03 3755 6 6 1.000 0.002 GO:0051716 BP 1 cellular response to stimulus 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.13e-03 12 6 2 0.333 0.167 HP:0001598 hp 1 Concave nail 1 P18074,Q6ZYL4 470 2.13e-03 12 6 2 0.333 0.167 HP:0001869 hp 1 Deep plantar creases 1 P18074,P28715 470 2.18e-03 108 6 2 0.333 0.019 GO:0008022 MF 1 protein C-terminus binding 1 P18074,P50613 470 2.49e-03 3882 6 6 1.000 0.002 GO:0016043 BP 1 cellular component organization 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.51e-03 13 6 2 0.333 0.154 HP:0003683 hp 1 Large beaked nose 1 P18074,P28715 470 2.52e-03 2267 6 5 0.833 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.58e-03 504 6 3 0.500 0.006 GO:0044087 BP 1 regulation of cellular component biogenesis 1 P18074,P28715,Q6ZYL4 470 2.67e-03 4742 6 6 1.000 0.001 TF:M00137_1 tf 1 Factor: Oct-1; motif: NNNRTAATNANNN; match class: 1 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.73e-03 2305 6 5 0.833 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.75e-03 3948 6 6 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.76e-03 2310 6 5 0.833 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.04e-03 4013 6 6 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.14e-03 2374 6 5 0.833 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.37e-03 15 6 2 0.333 0.133 HP:0008887 hp 1 Adipose tissue loss 1 P18074,Q6ZYL4 470 3.37e-03 15 6 2 0.333 0.133 HP:0007479 hp 1 Congenital nonbullous ichthyosiform erythroderma 1 P18074,Q6ZYL4 470 3.82e-03 577 6 3 0.500 0.005 GO:0051338 BP 1 regulation of transferase activity 1 P51948,P50613,P51946 470 4.11e-03 448 6 3 0.500 0.007 REAC:69278 rea 1 Cell Cycle, Mitotic 1 P51948,P50613,P51946 470 4.19e-03 218 6 2 0.333 0.009 TF:M02266_0 tf 1 Factor: HNF1B; motif: TTAATRWTTAAC; match class: 0 1 P28715,Q6ZYL4 470 4.24e-03 9 6 1 0.167 0.111 TF:M05506_0 tf 1 Factor: ZNF392; motif: KGGTACAAGAAM; match class: 0 1 P50613 470 4.35e-03 153 6 2 0.333 0.013 GO:0071103 BP 1 DNA conformation change 1 P18074,Q6ZYL4 470 4.37e-03 4264 6 6 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.46e-03 5 6 1 0.167 0.200 GO:0071817 CC 1 MMXD complex 1 P18074 470 4.52e-03 156 6 2 0.333 0.013 GO:0009416 BP 1 response to light stimulus 1 P18074,P28715 470 4.90e-03 18 6 2 0.333 0.111 HP:0007633 hp 1 Bilateral microphthalmos 1 P18074,P28715 470 4.90e-03 18 6 2 0.333 0.111 HP:0001808 hp 1 Fragile nails 1 P18074,Q6ZYL4 470 4.97e-03 4356 6 6 1.000 0.001 GO:0050896 BP 1 response to stimulus 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 5.10e-03 2627 6 5 0.833 0.002 GO:0016070 BP 1 RNA metabolic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 5.36e-03 6 6 1 0.167 0.167 GO:0043139 MF 1 5'-3' DNA helicase activity 1 P18074 470 5.36e-03 6 6 1 0.167 0.167 GO:0010225 BP 1 response to UV-C 1 P28715 470 5.36e-03 6 6 1 0.167 0.167 GO:0000405 MF 1 bubble DNA binding 1 P28715 470 5.47e-03 19 6 2 0.333 0.105 HP:0002283 hp 1 Global brain atrophy 1 P18074,Q6ZYL4 470 5.50e-03 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 5.64e-03 12 6 1 0.167 0.083 TF:M06118_0 tf 1 Factor: ZNF23; motif: NGGTAAWGGTTN; match class: 0 1 P28715 470 5.85e-03 1907 6 4 0.667 0.002 TF:M03892_0 tf 1 Factor: VDR:RXR-alpha; motif: RRGGTCAN; match class: 0 1 P51948,P18074,P50613,P28715 470 5.89e-03 2707 6 5 0.833 0.002 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 6.04e-03 5433 6 6 1.000 0.001 TF:M00162_0 tf 1 Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 0 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 6.30e-03 916 6 3 0.500 0.003 TF:M03889_1 tf 1 Factor: TBX2; motif: AGGTGTGARM; match class: 1 1 P18074,P50613,Q6ZYL4 470 6.57e-03 2770 6 5 0.833 0.002 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 6.66e-03 700 6 3 0.500 0.004 GO:0001932 BP 1 regulation of protein phosphorylation 1 P51948,P50613,P51946 470 6.70e-03 21 6 2 0.333 0.095 HP:0003328 hp 1 Abnormal hair laboratory examination 1 P18074,Q6ZYL4 470 6.70e-03 21 6 2 0.333 0.095 HP:0003254 hp 1 Abnormality of DNA repair 1 P18074,P28715 470 6.70e-03 21 6 2 0.333 0.095 HP:0040063 hp 1 Decreased adipose tissue 1 P18074,Q6ZYL4 470 6.85e-03 707 6 3 0.500 0.004 GO:0051130 BP 1 positive regulation of cellular component organization 1 P18074,P28715,Q6ZYL4 470 7.14e-03 8 6 1 0.167 0.125 GO:1901409 BP 1 positive regulation of phosphorylation of RNA polymerase II C-terminal domain 1 P51946 470 7.26e-03 547 6 3 0.500 0.005 REAC:1640170 rea 1 Cell Cycle 1 P51948,P50613,P51946 470 7.36e-03 22 6 2 0.333 0.091 HP:0007431 hp 1 Congenital ichthyosiform erythroderma 1 P18074,Q6ZYL4 470 7.68e-03 5655 6 6 1.000 0.001 TF:M00980_0 tf 1 Factor: TBP; motif: TTTATAN; match class: 0 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 7.76e-03 2869 6 5 0.833 0.002 GO:0009059 BP 1 macromolecule biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 8.03e-03 9 6 1 0.167 0.111 GO:1901407 BP 1 regulation of phosphorylation of RNA polymerase II C-terminal domain 1 P51946 470 8.16e-03 1635 6 4 0.667 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 P51948,P18074,P50613,P51946 470 8.33e-03 1644 6 4 0.667 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 P51948,P18074,P50613,P51946 470 8.42e-03 760 6 3 0.500 0.004 GO:0042325 BP 1 regulation of phosphorylation 1 P51948,P50613,P51946 470 8.56e-03 1656 6 4 0.667 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 P51948,P18074,P50613,P51946 470 8.70e-03 1663 6 4 0.667 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 P51948,P18074,P50613,P51946 470 8.89e-03 321 6 2 0.333 0.006 TF:M01971_1 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 1 P18074,P50613 470 9.05e-03 1681 6 4 0.667 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 P51948,P18074,P50613,P51946 470 9.54e-03 25 6 2 0.333 0.080 HP:0005487 hp 1 Prominent metopic ridge 1 P18074,P28715 470 9.54e-03 25 6 2 0.333 0.080 HP:0002217 hp 1 Slow-growing hair 1 P18074,Q6ZYL4 470 9.54e-03 25 6 2 0.333 0.080 HP:0011363 hp 1 Abnormality of hair growth rate 1 P18074,Q6ZYL4 470 9.63e-03 1065 6 3 0.500 0.003 TF:M01971_0 tf 1 Factor: LHX3b; motif: AATTAATTWN; match class: 0 1 P18074,P50613,P51946 470 9.76e-03 1715 6 4 0.667 0.002 GO:0016740 MF 1 transferase activity 1 P51948,P18074,P50613,P51946 470 9.81e-03 11 6 1 0.167 0.091 GO:0035315 BP 1 hair cell differentiation 1 P18074 470 9.92e-03 233 6 2 0.333 0.009 GO:0009314 BP 1 response to radiation 1 P18074,P28715 470 9.93e-03 12 6 1 0.167 0.083 REAC:2564830 rea 1 Cytosolic iron-sulfur cluster assembly 1 P18074 470 1.00e-02 1 6 1 0.167 1.000 OMIM:278780 omi 1 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G; XPG;;XP, GROUP G; XPGC;;XERODERMA PIGMENTOSUM VII; XP7XERODERMA PIGMENTOSUM, TYPE G/COCKAYNE SYNDROME, INCLUDED; XPG/CS,INCLUDED 1 P28715 470 1.00e-02 1 6 1 0.167 1.000 OMIM:616570 omi 1 CEREBROOCULOFACIOSKELETAL SYNDROME 3; COFS3 1 P28715 470 1.00e-02 1 6 1 0.167 1.000 OMIM:610756 omi 1 CEREBROOCULOFACIOSKELETAL SYNDROME 2; COFS2 1 P18074 470 1.00e-02 1 6 1 0.167 1.000 OMIM:616395 omi 1 TRICHOTHIODYSTROPHY 3, PHOTOSENSITIVE; TTD3;;TRICHOTHIODYSTROPHY, COMPLEMENTATION GROUP A; TTDA 1 Q6ZYL4 470 1.00e-02 1 6 1 0.167 1.000 OMIM:278730 omi 1 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP D; XPD;;XP, GROUP D; XPDC;;XERODERMA PIGMENTOSUM IV;;XP4 XERODERMA PIGMENTOSUM VIII, FORMERLY; XP8, FORMERLY;;XP, GROUP H, FORMERLY; XPH, FORMERLY 1 P18074 470 1.01e-02 5019 6 6 1.000 0.001 HPA:028010_02 hpa 1 parathyroid gland; glandular cells[Uncertain,Medium] 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.03e-02 26 6 2 0.333 0.077 HP:0040170 hp 1 Abnormality of hair growth 1 P18074,Q6ZYL4 470 1.04e-02 1745 6 4 0.667 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 P51948,P18074,P50613,P51946 470 1.05e-02 3058 6 5 0.833 0.002 GO:0010467 BP 1 gene expression 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.07e-02 311 6 2 0.333 0.006 MI:hsa-miR-183* mi 1 MI:hsa-miR-183* 1 P51948,P28715 470 1.08e-02 23 6 1 0.167 0.043 TF:M06321_0 tf 1 Factor: ZNF79; motif: KGTTAAAAAATM; match class: 0 1 Q6ZYL4 470 1.11e-02 1775 6 4 0.667 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 P51948,P18074,P50613,P51946 470 1.12e-02 4990 6 6 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.13e-02 3848 6 5 0.833 0.001 TF:M03888_1 tf 1 Factor: Sox6; motif: NARACAAAARN; match class: 1 1 P51948,P18074,P51946,P28715,Q6ZYL4 470 1.15e-02 2288 6 4 0.667 0.002 TF:M00233_0 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 0 1 P51948,P18074,P28715,Q6ZYL4 470 1.19e-02 329 6 2 0.333 0.006 MI:hsa-miR-33a* mi 1 MI:hsa-miR-33a* 1 P50613,P51946 470 1.20e-02 28 6 2 0.333 0.071 HP:0001019 hp 1 Erythroderma 1 P18074,Q6ZYL4 470 1.25e-02 14 6 1 0.167 0.071 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 P50613 470 1.25e-02 14 6 1 0.167 0.071 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 P50613 470 1.25e-02 14 6 1 0.167 0.071 GO:0070816 BP 1 phosphorylation of RNA polymerase II C-terminal domain 1 P51946 470 1.26e-02 6143 6 6 1.000 0.001 TF:M01894_1 tf 1 Factor: YY1; motif: CCATNTT; match class: 1 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.29e-02 29 6 2 0.333 0.069 HP:0005556 hp 1 Abnormality of the metopic suture 1 P18074,P28715 470 1.29e-02 1002 6 3 0.500 0.003 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P18074,P50613,P28715 470 1.30e-02 885 6 3 0.500 0.003 GO:0019220 BP 1 regulation of phosphate metabolic process 1 P51948,P50613,P51946 470 1.34e-02 15 6 1 0.167 0.067 GO:0005662 CC 1 DNA replication factor A complex 1 P28715 470 1.35e-02 897 6 3 0.500 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 P51948,P50613,P51946 470 1.38e-02 30 6 2 0.333 0.067 HP:0100492 hp 1 Joint contractures involving the joints of the feet 1 P18074,P28715 470 1.38e-02 30 6 2 0.333 0.067 HP:0005830 hp 1 Flexion contracture of toe 1 P18074,P28715 470 1.39e-02 356 6 2 0.333 0.006 MI:hsa-miR-10a* mi 1 MI:hsa-miR-10a* 1 P50613,P28715 470 1.44e-02 412 6 2 0.333 0.005 TF:M05870_0 tf 1 Factor: ZNF625; motif: NARWTGKATMGA; match class: 0 1 P51946,P28715 470 1.47e-02 31 6 2 0.333 0.065 HP:0002299 hp 1 Brittle hair 1 P18074,Q6ZYL4 470 1.49e-02 1923 6 4 0.667 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 P51948,P18074,P50613,P51946 470 1.49e-02 2459 6 4 0.667 0.002 TF:M03919_0 tf 1 Factor: slug; motif: NRCAGGTGN; match class: 0 1 P18074,P50613,P28715,Q6ZYL4 470 1.50e-02 32 6 1 0.167 0.031 TF:M05971_0 tf 1 Factor: ZNF860; motif: NTGGMCGAAAGA; match class: 0 1 P18074 470 1.57e-02 32 6 2 0.333 0.062 HP:0006380 hp 1 Knee flexion contracture 1 P18074,P28715 470 1.64e-02 442 6 2 0.333 0.005 TF:M00023_0 tf 1 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN; match class: 0 1 P51948,P51946 470 1.65e-02 5319 6 6 1.000 0.001 GO:0043170 BP 1 macromolecule metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.65e-02 1976 6 4 0.667 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 P51948,P18074,P50613,P51946 470 1.66e-02 967 6 3 0.500 0.003 GO:0031399 BP 1 regulation of protein modification process 1 P51948,P50613,P51946 470 1.67e-02 33 6 2 0.333 0.061 HP:0003015 hp 1 Flared metaphysis 1 P18074,P28715 470 1.67e-02 392 6 2 0.333 0.005 MI:hsa-miR-190 mi 1 MI:hsa-miR-190 1 P51948,P51946 470 1.71e-02 1994 6 4 0.667 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 P51948,P18074,P50613,P51946 470 1.72e-02 398 6 2 0.333 0.005 MI:hsa-miR-302a* mi 1 MI:hsa-miR-302a* 1 P51948,P51946 470 1.74e-02 400 6 2 0.333 0.005 MI:hsa-miR-10b* mi 1 MI:hsa-miR-10b* 1 P50613,P28715 470 1.76e-02 458 6 2 0.333 0.004 TF:M04625_1 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 1 1 P51948,Q6ZYL4 470 1.76e-02 4233 6 5 0.833 0.001 TF:M01012_1 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 1 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 1.77e-02 34 6 2 0.333 0.059 HP:0004315 hp 1 IgG deficiency 1 P18074,Q6ZYL4 470 1.78e-02 5517 6 6 1.000 0.001 HPA:006030_01 hpa 1 cerebellum; cells in molecular layer[Uncertain,Low] 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 1.78e-02 20 6 1 0.167 0.050 GO:0000217 MF 1 DNA secondary structure binding 1 P28715 470 1.87e-02 21 6 1 0.167 0.048 GO:0016538 MF 1 cyclin-dependent protein serine/threonine kinase regulator activity 1 P51946 470 1.87e-02 35 6 2 0.333 0.057 HP:0001338 hp 1 Partial agenesis of the corpus callosum 1 P18074,Q6ZYL4 470 1.90e-02 1359 6 3 0.500 0.002 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 P51948,P51946,P28715 470 1.90e-02 4302 6 5 0.833 0.001 TF:M04402_1 tf 1 Factor: MIXL1; motif: NNYAATTANN; match class: 1 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.90e-02 4305 6 5 0.833 0.001 TF:M04081_0 tf 1 Factor: POU3F3; motif: WTGMATAAWTWA; match class: 0 1 P51948,P18074,P50613,P51946,P28715 470 1.95e-02 2068 6 4 0.667 0.002 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 P51948,P18074,P50613,P51946 470 1.97e-02 3499 6 5 0.833 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 1.98e-02 36 6 2 0.333 0.056 HP:0002673 hp 1 Coxa valga 1 P18074,P28715 470 2.03e-02 2090 6 4 0.667 0.002 GO:0009889 BP 1 regulation of biosynthetic process 1 P51948,P18074,P50613,P51946 470 2.09e-02 5533 6 6 1.000 0.001 GO:0050794 BP 1 regulation of cellular process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.09e-02 37 6 2 0.333 0.054 HP:0000046 hp 1 Scrotal hypoplasia 1 P18074,P28715 470 2.09e-02 37 6 2 0.333 0.054 HP:0003100 hp 1 Slender long bone 1 P18074,P28715 470 2.09e-02 37 6 2 0.333 0.054 HP:0000965 hp 1 Cutis marmorata 1 P18074,Q6ZYL4 470 2.17e-02 3569 6 5 0.833 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.20e-02 1068 6 3 0.500 0.003 GO:0006468 BP 1 protein phosphorylation 1 P51948,P50613,P51946 470 2.21e-02 38 6 2 0.333 0.053 HP:0006829 hp 1 Severe muscular hypotonia 1 P18074,Q6ZYL4 470 2.21e-02 1071 6 3 0.500 0.003 GO:0050790 BP 1 regulation of catalytic activity 1 P51948,P50613,P51946 470 2.22e-02 1221 6 3 0.500 0.002 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 P18074,P50613,P28715 470 2.22e-02 25 6 1 0.167 0.040 GO:1904031 BP 1 positive regulation of cyclin-dependent protein kinase activity 1 P51946 470 2.22e-02 25 6 1 0.167 0.040 GO:0045737 BP 1 positive regulation of cyclin-dependent protein serine/threonine kinase activity 1 P51946 470 2.24e-02 48 6 1 0.167 0.021 TF:M06103_0 tf 1 Factor: ZNF325; motif: NKGGCAAGAARM; match class: 0 1 P51948 470 2.31e-02 26 6 1 0.167 0.038 GO:0043601 CC 1 nuclear replisome 1 P28715 470 2.31e-02 3620 6 5 0.833 0.001 GO:0009058 BP 1 biosynthetic process 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.32e-02 39 6 2 0.333 0.051 HP:0001531 hp 1 Failure to thrive in infancy 1 P18074,P28715 470 2.33e-02 6 6 1 0.167 0.167 CORUM:2638 cor 1 HES1 promoter corepressor complex 1 P50613 470 2.34e-02 2173 6 4 0.667 0.002 GO:0010468 BP 1 regulation of gene expression 1 P51948,P18074,P50613,P51946 470 2.40e-02 27 6 1 0.167 0.037 GO:0030894 CC 1 replisome 1 P28715 470 2.42e-02 2192 6 4 0.667 0.002 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 P51948,P18074,P50613,P51946 470 2.43e-02 2813 6 4 0.667 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 P51948,P50613,P28715,Q6ZYL4 470 2.43e-02 52 6 1 0.167 0.019 TF:M06656_0 tf 1 Factor: ZNF436; motif: NTGGTGGGCGGA; match class: 0 1 P50613 470 2.44e-02 40 6 2 0.333 0.050 HP:0006481 hp 1 Abnormality of primary teeth 1 P18074,Q6ZYL4 470 2.44e-02 40 6 2 0.333 0.050 HP:0006610 hp 1 Wide intermamillary distance 1 P18074,P28715 470 2.44e-02 40 6 2 0.333 0.050 HP:0040157 hp 1 Abnormal intermamillary distance 1 P18074,P28715 470 2.45e-02 480 6 2 0.333 0.004 MI:hsa-miR-450a mi 1 MI:hsa-miR-450a 1 P51948,P28715 470 2.47e-02 53 6 1 0.167 0.019 TF:M04003_0 tf 1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 0 1 P51946 470 2.47e-02 53 6 1 0.167 0.019 TF:M05879_0 tf 1 Factor: ZNF713; motif: GTTGATAATC; match class: 0 1 P50613 470 2.52e-02 4575 6 5 0.833 0.001 TF:M04443_1 tf 1 Factor: UNCX; motif: NYAATTAN; match class: 1 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 2.52e-02 54 6 1 0.167 0.019 TF:M04459_0 tf 1 Factor: ESRRB; motif: TCAAGGTCAWN; match class: 0 1 P51948 470 2.72e-02 489 6 2 0.333 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P18074,P50613 470 2.72e-02 1317 6 3 0.500 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 P18074,P50613,P28715 470 2.74e-02 5787 6 6 1.000 0.001 GO:0044446 CC 1 intracellular organelle part 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.84e-02 160 6 3 0.500 0.019 HP:0001321 hp 1 Cerebellar hypoplasia 1 P18074,P28715,Q6ZYL4 470 2.89e-02 5839 6 6 1.000 0.001 GO:0050789 BP 1 regulation of biological process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 2.89e-02 161 6 3 0.500 0.019 HP:0009473 hp 1 Joint contracture of the hand 1 P18074,P28715,Q6ZYL4 470 2.90e-02 4719 6 5 0.833 0.001 TF:M04082_1 tf 1 Factor: POU3F3; motif: WTNAATAWKNAW; match class: 1 1 P51948,P18074,P51946,P28715,Q6ZYL4 470 2.91e-02 4006 6 5 0.833 0.001 HPA:029010_02 hpa 1 placenta; decidual cells[Uncertain,Medium] 1 P51948,P18074,P50613,P28715,Q6ZYL4 470 2.93e-02 63 6 1 0.167 0.016 TF:M06073_0 tf 1 Factor: ZNF749; motif: KTGGCTGGTTT; match class: 0 1 P28715 470 2.95e-02 4737 6 5 0.833 0.001 TF:M04393_0 tf 1 Factor: LMX1B; motif: NYAATTAN; match class: 0 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.00e-02 607 6 2 0.333 0.003 TF:M04430_1 tf 1 Factor: Prop-1; motif: TAATYNAATTA; match class: 1 1 P18074,P50613 470 3.00e-02 5877 6 6 1.000 0.001 GO:0044422 CC 1 organelle part 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.03e-02 65 6 1 0.167 0.015 TF:M06433_0 tf 1 Factor: ZNF571; motif: NTGTCAASATSM; match class: 0 1 P50613 470 3.07e-02 4778 6 5 0.833 0.001 TF:M00160_1 tf 1 Factor: SRY; motif: NWWAACAAWANN; match class: 1 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 3.08e-02 3008 6 4 0.667 0.001 TF:M00232_0 tf 1 Factor: MEF-2A; motif: NNNNNWKCTAWAAATAGMNNNN; match class: 0 1 P51948,P18074,P28715,Q6ZYL4 470 3.09e-02 617 6 2 0.333 0.003 TF:M04089_1 tf 1 Factor: POU5F1B; motif: ATGMATATKCAW; match class: 1 1 P51948,P18074 470 3.09e-02 8 6 1 0.167 0.125 CORUM:3067 cor 1 RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying 1 P51946 470 3.10e-02 35 6 1 0.167 0.029 GO:0050681 MF 1 androgen receptor binding 1 P50613 470 3.22e-02 46 6 2 0.333 0.043 HP:0000687 hp 1 Widely spaced teeth 1 P18074,Q6ZYL4 470 3.23e-02 1403 6 3 0.500 0.002 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 P18074,P50613,P28715 470 3.31e-02 4859 6 5 0.833 0.001 TF:M04360_1 tf 1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 3.33e-02 1419 6 3 0.500 0.002 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P18074,P50613,P28715 470 3.36e-02 47 6 2 0.333 0.043 HP:0003083 hp 1 Dislocated radial head 1 P18074,P28715 470 3.46e-02 3109 6 4 0.667 0.001 TF:M00809_1 tf 1 Factor: FOX; motif: KWTTGTTTRTTTW; match class: 1 1 P51948,P18074,P50613,P28715 470 3.47e-02 446 6 2 0.333 0.004 GO:0051276 BP 1 chromosome organization 1 P18074,Q6ZYL4 470 3.49e-02 172 6 3 0.500 0.017 HP:0000054 hp 1 Micropenis 1 P18074,P28715,Q6ZYL4 470 3.50e-02 4919 6 5 0.833 0.001 TF:M04402_0 tf 1 Factor: MIXL1; motif: NNYAATTANN; match class: 0 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 3.50e-02 48 6 2 0.333 0.042 HP:0008365 hp 1 Abnormality of the talus 1 P18074,P28715 470 3.50e-02 48 6 2 0.333 0.042 HP:0003995 hp 1 Abnormality of the radial head 1 P18074,P28715 470 3.50e-02 48 6 2 0.333 0.042 HP:0001838 hp 1 Rocker bottom foot 1 P18074,P28715 470 3.51e-02 1266 6 3 0.500 0.002 GO:0016310 BP 1 phosphorylation 1 P51948,P50613,P51946 470 3.54e-02 40 6 1 0.167 0.025 GO:0004520 MF 1 endodeoxyribonuclease activity 1 P28715 470 3.54e-02 40 6 1 0.167 0.025 GO:0043596 CC 1 nuclear replication fork 1 P28715 470 3.59e-02 1459 6 3 0.500 0.002 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P18074,P50613,P28715 470 3.71e-02 7353 6 6 1.000 0.001 TF:M07038_0 tf 1 Factor: DBP; motif: TTRCATAANN; match class: 0 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.73e-02 176 6 3 0.500 0.017 HP:0001274 hp 1 Agenesis of corpus callosum 1 P18074,P28715,Q6ZYL4 470 3.75e-02 4019 6 5 0.833 0.001 GO:0003824 MF 1 catalytic activity 1 P51948,P18074,P50613,P51946,P28715 470 3.86e-02 6128 6 6 1.000 0.001 GO:0044238 BP 1 primary metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 3.95e-02 51 6 2 0.333 0.039 HP:0100744 hp 1 Abnormality of the humeroradial joint 1 P18074,P28715 470 3.96e-02 1785 6 3 0.500 0.002 TF:M00626_1 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 1 1 P51948,P28715,Q6ZYL4 470 4.01e-02 1793 6 3 0.500 0.002 TF:M04126_1 tf 1 Factor: TBX1; motif: AGGTGTGA; match class: 1 1 P18074,P50613,Q6ZYL4 470 4.01e-02 1793 6 3 0.500 0.002 TF:M04117_1 tf 1 Factor: MGA; motif: AGGTGTGA; match class: 1 1 P18074,P50613,Q6ZYL4 470 4.01e-02 1793 6 3 0.500 0.002 TF:M04137_1 tf 1 Factor: Tbx5; motif: AGGTGTKA; match class: 1 1 P18074,P50613,Q6ZYL4 470 4.01e-02 1793 6 3 0.500 0.002 TF:M04122_1 tf 1 Factor: TBX15; motif: AGGTGTGA; match class: 1 1 P18074,P50613,Q6ZYL4 470 4.01e-02 1793 6 3 0.500 0.002 TF:M04135_1 tf 1 Factor: TBX4; motif: AGGTGTGA; match class: 1 1 P18074,P50613,Q6ZYL4 470 4.03e-02 5073 6 5 0.833 0.001 TF:M04335_1 tf 1 Factor: HMX3; motif: NNCAMTTAANN; match class: 1 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 4.08e-02 608 6 2 0.333 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 P18074,P50613 470 4.09e-02 3261 6 4 0.667 0.001 TF:M04030_0 tf 1 Factor: MEIS3; motif: NTGACAGN; match class: 0 1 P51948,P18074,P50613,P28715 470 4.11e-02 1535 6 3 0.500 0.002 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P18074,P50613,P28715 470 4.12e-02 1342 6 3 0.500 0.002 GO:0032268 BP 1 regulation of cellular protein metabolic process 1 P51948,P50613,P51946 470 4.16e-02 47 6 1 0.167 0.021 GO:0003678 MF 1 DNA helicase activity 1 P18074 470 4.23e-02 731 6 2 0.333 0.003 TF:M04309_0 tf 1 Factor: DUXA; motif: NTRAYYTAATCAN; match class: 0 1 P51948,P51946 470 4.26e-02 92 6 1 0.167 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 P51948 470 4.31e-02 6242 6 6 1.000 0.001 GO:0065007 BP 1 biological regulation 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.31e-02 5151 6 5 0.833 0.001 TF:M04392_0 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 0 1 P51948,P18074,P50613,P51946,Q6ZYL4 470 4.37e-02 631 6 2 0.333 0.003 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 P18074,P50613 470 4.42e-02 54 6 2 0.333 0.037 HP:0001181 hp 1 Adducted thumb 1 P18074,P28715 470 4.46e-02 1583 6 3 0.500 0.002 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P18074,P50613,P28715 470 4.49e-02 97 6 1 0.167 0.010 TF:M04005_0 tf 1 Factor: TCF7L1; motif: AAAGATCAAAGG; match class: 0 1 P51946 470 4.51e-02 5202 6 5 0.833 0.001 TF:M04514_1 tf 1 Factor: CPEB1; motif: AATAAAAA; match class: 1 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 4.51e-02 1388 6 3 0.500 0.002 GO:0065009 BP 1 regulation of molecular function 1 P51948,P50613,P51946 470 4.55e-02 6299 6 6 1.000 0.001 GO:0044237 BP 1 cellular metabolic process 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.58e-02 55 6 2 0.333 0.036 HP:0002987 hp 1 Elbow flexion contracture 1 P18074,P28715 470 4.61e-02 5229 6 5 0.833 0.001 TF:M07327_0 tf 1 Factor: Nanog; motif: NTNTAATGSN; match class: 0 1 P51948,P50613,P51946,P28715,Q6ZYL4 470 4.62e-02 519 6 2 0.333 0.004 GO:0009628 BP 1 response to abiotic stimulus 1 P18074,P28715 470 4.62e-02 100 6 1 0.167 0.010 TF:M05668_0 tf 1 Factor: ZNF154; motif: NGTGAAATCAGA; match class: 0 1 P51948 470 4.68e-02 53 6 1 0.167 0.019 GO:0035258 MF 1 steroid hormone receptor binding 1 P50613 470 4.68e-02 53 6 1 0.167 0.019 GO:0030521 BP 1 androgen receptor signaling pathway 1 P50613 470 4.74e-02 1621 6 3 0.500 0.002 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P18074,P50613,P28715 470 4.75e-02 1622 6 3 0.500 0.002 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P18074,P50613,P28715 470 4.75e-02 1622 6 3 0.500 0.002 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P18074,P50613,P28715 470 4.76e-02 1623 6 3 0.500 0.002 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P18074,P50613,P28715 470 4.77e-02 1916 6 3 0.500 0.002 TF:M04319_1 tf 1 Factor: ESX1; motif: NNYAATTANN; match class: 1 1 P51948,P50613,Q6ZYL4 470 4.88e-02 6526 6 6 1.000 0.001 HPA:044020_02 hpa 1 testis; cells in seminiferous ducts[Uncertain,Medium] 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.94e-02 107 6 1 0.167 0.009 TF:M01661_1 tf 1 Factor: hbp1; motif: BTCAATSAR; match class: 1 1 P51946 470 4.94e-02 56 6 1 0.167 0.018 GO:0004536 MF 1 deoxyribonuclease activity 1 P28715 470 4.94e-02 56 6 1 0.167 0.018 GO:0005657 CC 1 replication fork 1 P28715 470 4.96e-02 1438 6 3 0.500 0.002 GO:0051128 BP 1 regulation of cellular component organization 1 P18074,P28715,Q6ZYL4 470 4.97e-02 7718 6 6 1.000 0.001 TF:M01012_0 tf 1 Factor: HNF3; motif: NNNNNTRTTTRYTYWNKN; match class: 0 1 P51948,P18074,P50613,P51946,P28715,Q6ZYL4 470 4.99e-02 108 6 1 0.167 0.009 TF:M04165_0 tf 1 Factor: BHLHE23; motif: AMCATATGYT; match class: 0 1 P28715 470 5.00e-02 5 6 1 0.167 0.200 OMIM:216400 omi 1 Cockayne Syndrome 1 P28715 470 5.00e-02 195 6 3 0.500 0.015 HP:0100360 hp 1 Contractures of the joints of the upper limbs 1 P18074,P28715,Q6ZYL4 470 5.00e-02 117 6 2 0.333 0.017 KEGG:04110 keg 1 Cell cycle 1 P50613,P51946 470 5.00e-02 13 6 1 0.167 0.077 CORUM:2639 cor 1 HES1 promoter-Notch enhancer complex 1 P50613 470 5.00e-02 1442 6 3 0.500 0.002 GO:0051246 BP 1 regulation of protein metabolic process 1 P51948,P50613,P51946 471 9.20e-03 1108 5 3 0.600 0.003 HPA:021020_03 hpa 1 liver; hepatocytes[Uncertain,High] 1 Q96AN5,Q9H228,A0PK00 471 9.51e-03 357 5 2 0.400 0.006 MI:hsa-miR-27a* mi 1 MI:hsa-miR-27a* 1 Q96AN5,Q9H228 471 1.05e-02 376 5 2 0.400 0.005 MI:hsa-miR-92a-1* mi 1 MI:hsa-miR-92a-1* 1 Q6P5W5,Q96AN5 471 1.36e-02 430 5 2 0.400 0.005 MI:hsa-miR-450b-3p mi 1 MI:hsa-miR-450b-3p 1 Q6P5W5,Q9H228 471 1.57e-02 463 5 2 0.400 0.004 MI:hsa-miR-338-3p mi 1 MI:hsa-miR-338-3p 1 Q9H228,A0PK00 471 1.70e-02 482 5 2 0.400 0.004 MI:hsa-miR-769-3p mi 1 MI:hsa-miR-769-3p 1 Q6P5W5,Q9H228 471 1.74e-02 489 5 2 0.400 0.004 MI:hsa-miR-23b mi 1 MI:hsa-miR-23b 1 Q9H228,A0PK00 471 1.85e-02 7 5 1 0.200 0.143 REAC:442380 rea 1 Zinc influx into cells by the SLC39 gene family 1 Q6P5W5 471 1.85e-02 7 5 1 0.200 0.143 REAC:419408 rea 1 Lysosphingolipid and LPA receptors 1 Q9H228 471 2.00e-02 1462 5 3 0.600 0.002 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 Q8NBJ4,Q96AN5,A0PK00 471 2.05e-02 533 5 2 0.400 0.004 MI:hsa-miR-124 mi 1 MI:hsa-miR-124 1 Q6P5W5,Q9H228 471 3.41e-02 35 5 1 0.200 0.029 KEGG:04978 keg 1 Mineral absorption 1 Q6P5W5 471 3.43e-02 13 5 1 0.200 0.077 REAC:435354 rea 1 Zinc transporters 1 Q6P5W5 471 4.19e-02 2 5 1 0.200 0.500 TF:M00467_0 tf 1 Factor: Roaz; motif: GCACCCAWGGGTGM; match class: 0 1 Q96AN5 471 5.00e-02 2 5 1 0.200 0.500 HP:0003282 hp 1 Low alkaline phosphatase 1 Q6P5W5 471 5.00e-02 2 5 1 0.200 0.500 HP:0008230 hp 1 Decreased testosterone in males 1 Q6P5W5 471 5.00e-02 5 5 1 0.200 0.200 GO:0071578 BP 1 zinc II ion transmembrane import 1 Q6P5W5 471 5.00e-02 2 5 1 0.200 0.500 HP:0005401 hp 1 Recurrent candida infections 1 Q6P5W5 471 5.00e-02 1 5 1 0.200 1.000 OMIM:201100 omi 1 ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE; AEZ 1 Q6P5W5 471 5.00e-02 2 5 1 0.200 0.500 HP:0000206 hp 1 Glossitis 1 Q6P5W5 471 5.00e-02 3157 5 5 1.000 0.002 TF:M00051_0 tf 1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 0 1 Q8NBJ4,Q6P5W5,Q96AN5,Q9H228,A0PK00 471 5.00e-02 19 5 1 0.200 0.053 REAC:425410 rea 1 Metal ion SLC transporters 1 Q6P5W5 472 3.80e-08 16 4 3 0.750 0.188 REAC:156711 rea 1 Polo-like kinase mediated events 1 Q5TKA1,Q52LA3,Q96GY3 472 1.56e-07 25 4 3 0.750 0.120 REAC:1538133 rea 1 G0 and Early G1 1 Q5TKA1,Q52LA3,Q96GY3 472 2.84e-07 5 4 3 0.750 0.600 CORUM:5593 cor 1 LINC core complex 1 Q5TKA1,Q52LA3,Q96GY3 472 9.93e-07 7 4 3 0.750 0.429 CORUM:5596 cor 1 LINC complex, quiescent cells 1 Q5TKA1,Q52LA3,Q96GY3 472 9.93e-07 7 4 3 0.750 0.429 CORUM:5589 cor 1 LINC complex, S-phase 1 Q5TKA1,Q52LA3,Q96GY3 472 2.87e-05 138 4 3 0.750 0.022 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 Q5TKA1,Q52LA3,Q96GY3 472 5.47e-05 171 4 3 0.750 0.018 REAC:69275 rea 1 G2/M Transition 1 Q5TKA1,Q52LA3,Q96GY3 472 5.67e-05 173 4 3 0.750 0.017 REAC:453274 rea 1 Mitotic G2-G2/M phases 1 Q5TKA1,Q52LA3,Q96GY3 472 9.66e-04 448 4 3 0.750 0.007 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q5TKA1,Q52LA3,Q96GY3 472 1.57e-03 5 4 1 0.250 0.200 TF:M06078_1 tf 1 Factor: ZNF878; motif: NGGGARATTT; match class: 1 1 Q96GY3 472 1.74e-03 547 4 3 0.750 0.005 REAC:1640170 rea 1 Cell Cycle 1 Q5TKA1,Q52LA3,Q96GY3 472 1.86e-03 227 4 2 0.500 0.009 TF:M00465_0 tf 1 Factor: POU6F1; motif: GCATAAWTTAT; match class: 0 1 Q5TKA1,P10243 472 2.12e-03 243 4 2 0.500 0.008 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 Q52LA3,Q96GY3 472 4.08e-03 13 4 1 0.250 0.077 TF:M00097_1 tf 1 Factor: Pax-6; motif: NNNNTTCACGCWTGANTKNNN; match class: 1 1 P10243 472 4.47e-03 1359 4 3 0.750 0.002 TF:M00131_1 tf 1 Factor: HNF3beta; motif: KGNANTRTTTRYTTW; match class: 1 1 Q5TKA1,P10243,Q52LA3 472 6.04e-03 1507 4 3 0.750 0.002 TF:M00403_0 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 0 1 Q5TKA1,P10243,Q52LA3 472 6.24e-03 420 4 2 0.500 0.005 TF:M06171_0 tf 1 Factor: ZNF138; motif: NCTGGCAAGANA; match class: 0 1 P10243,Q52LA3 472 8.70e-03 1709 4 3 0.750 0.002 TF:M00804_0 tf 1 Factor: E2A; motif: NCACCTGYYNCNKN; match class: 0 1 Q5TKA1,Q52LA3,Q96GY3 472 8.80e-03 501 4 2 0.500 0.004 TF:M02075_1 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 1 1 Q52LA3,Q96GY3 472 9.82e-03 530 4 2 0.500 0.004 TF:M00419_0 tf 1 Factor: MEIS1; motif: NNNTGACAGNNN; match class: 0 1 Q5TKA1,Q52LA3 472 1.04e-02 4064 4 4 1.000 0.001 TF:M01594_1 tf 1 Factor: TCF-3; motif: NCTTTGWTNTKYW; match class: 1 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 1.22e-02 39 4 1 0.250 0.026 TF:M05799_0 tf 1 Factor: ZNF605; motif: NTTWTAATACGA; match class: 0 1 Q5TKA1 472 1.23e-02 595 4 2 0.500 0.003 TF:M00483_1 tf 1 Factor: ATF6; motif: TGACGTGG; match class: 1 1 Q52LA3,Q96GY3 472 1.29e-02 1959 4 3 0.750 0.002 TF:M04626_0 tf 1 Factor: Prop-1; motif: WNCTWATT; match class: 0 1 Q5TKA1,P10243,Q52LA3 472 1.34e-02 43 4 1 0.250 0.023 TF:M05418_0 tf 1 Factor: ZNF521; motif: NKGGGGGCCGGA; match class: 0 1 Q5TKA1 472 1.34e-02 43 4 1 0.250 0.023 TF:M05648_0 tf 1 Factor: ZNF883; motif: KGTGGCTGCCTC; match class: 0 1 Q96GY3 472 1.41e-02 4387 4 4 1.000 0.001 TF:M07432_0 tf 1 Factor: Sox2; motif: NNNNNAACAAWGN; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 1.50e-02 48 4 1 0.250 0.021 TF:M06103_0 tf 1 Factor: ZNF325; motif: NKGGCAAGAARM; match class: 0 1 P10243 472 1.59e-02 27 4 1 0.250 0.037 REAC:5601884 rea 1 PIWI-interacting RNA (piRNA) biogenesis 1 P10243 472 1.66e-02 53 4 1 0.250 0.019 TF:M03922_0 tf 1 Factor: SP4; motif: NWRGCCACGCCCMCTYN; match class: 0 1 Q52LA3 472 1.78e-02 57 4 1 0.250 0.018 TF:M06694_0 tf 1 Factor: ZNF160; motif: NGGTCAGCCAGC; match class: 0 1 Q52LA3 472 1.84e-02 59 4 1 0.250 0.017 TF:M03955_0 tf 1 Factor: ONECUT1; motif: NAAAAATCRATANN; match class: 0 1 Q52LA3 472 1.93e-02 2255 4 3 0.750 0.001 TF:M00405_0 tf 1 Factor: MEF-2A; motif: CKSTYTAAAAAWRMCY; match class: 0 1 Q5TKA1,P10243,Q52LA3 472 2.04e-02 773 4 2 0.500 0.003 TF:M00294_1 tf 1 Factor: HFH8; motif: NNNTGTTTATNTR; match class: 1 1 Q5TKA1,Q52LA3 472 2.12e-02 68 4 1 0.250 0.015 TF:M06581_0 tf 1 Factor: ZNF778; motif: NGGWKMAACCGM; match class: 0 1 Q5TKA1 472 2.16e-02 4879 4 4 1.000 0.001 TF:M07319_0 tf 1 Factor: HFH2; motif: AAACAAAN; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 2.23e-02 2372 4 3 0.750 0.001 TF:M04627_0 tf 1 Factor: Rfx1; motif: GTTGCYNNGGARMS; match class: 0 1 Q5TKA1,P10243,Q96GY3 472 2.23e-02 4919 4 4 1.000 0.001 TF:M04402_0 tf 1 Factor: MIXL1; motif: NNYAATTANN; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 2.24e-02 72 4 1 0.250 0.014 TF:M06561_0 tf 1 Factor: ZNF502; motif: NGGGWAAGACT; match class: 0 1 Q52LA3 472 2.24e-02 72 4 1 0.250 0.014 TF:M07343_1 tf 1 Factor: zbtb2; motif: AANAGCYCAGB; match class: 1 1 Q52LA3 472 2.43e-02 78 4 1 0.250 0.013 TF:M03956_0 tf 1 Factor: ONECUT2; motif: NAAAAATCRATANN; match class: 0 1 Q52LA3 472 2.53e-02 866 4 2 0.500 0.002 TF:M00024_0 tf 1 Factor: E2F; motif: TWSGCGCGAAAAYKR; match class: 0 1 Q5TKA1,Q52LA3 472 2.60e-02 879 4 2 0.500 0.002 TF:M02066_1 tf 1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 1 P10243,Q96GY3 472 2.68e-02 5151 4 4 1.000 0.001 TF:M04392_0 tf 1 Factor: LMX1A; motif: NTAATTAA; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 2.69e-02 894 4 2 0.500 0.002 TF:M07218_0 tf 1 Factor: MEF-2A; motif: NKCTAAAAATAGMNN; match class: 0 1 Q52LA3,Q96GY3 472 2.76e-02 906 4 2 0.500 0.002 TF:M00195_1 tf 1 Factor: Oct-1; motif: NNNNATGCAAATNAN; match class: 1 1 Q5TKA1,P10243 472 2.83e-02 5220 4 4 1.000 0.001 TF:M00422_0 tf 1 Factor: FOXJ2; motif: NNNWAAAYAAAYANNNNN; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 2.86e-02 92 4 1 0.250 0.011 TF:M05535_0 tf 1 Factor: ZNF513; motif: GKGGTAAATW; match class: 0 1 P10243 472 2.93e-02 936 4 2 0.500 0.002 TF:M04184_0 tf 1 Factor: NHLH1; motif: CGCAGCTGCK; match class: 0 1 Q5TKA1,P10243 472 3.02e-02 2644 4 3 0.750 0.001 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 Q5TKA1,P10243,Q96GY3 472 3.15e-02 5365 4 4 1.000 0.001 TF:M04403_0 tf 1 Factor: MNX1; motif: NNYAATTAAN; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 3.15e-02 5365 4 4 1.000 0.001 TF:M00349_0 tf 1 Factor: GATA-2; motif: ASAGATAANA; match class: 0 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 3.17e-02 102 4 1 0.250 0.010 TF:M06622_0 tf 1 Factor: ZNF681; motif: NKGGGAAAACSA; match class: 0 1 Q52LA3 472 3.35e-02 108 4 1 0.250 0.009 TF:M00403_1 tf 1 Factor: aMEF-2; motif: CKGDYTAAAAATAACYMM; match class: 1 1 Q5TKA1 472 3.52e-02 1031 4 2 0.500 0.002 TF:M03998_1 tf 1 Factor: GATA4; motif: WGATAANN; match class: 1 1 Q5TKA1,Q52LA3 472 3.90e-02 126 4 1 0.250 0.008 TF:M04029_1 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 1 1 P10243 472 3.90e-02 126 4 1 0.250 0.008 TF:M00045_0 tf 1 Factor: E4BP4; motif: NRTTAYGTAAYN; match class: 0 1 Q5TKA1 472 4.12e-02 2953 4 3 0.750 0.001 TF:M00231_0 tf 1 Factor: MEF-2A; motif: NNNNNNKCTAWAAATAGMNNNN; match class: 0 1 P10243,Q52LA3,Q96GY3 472 4.27e-02 138 4 1 0.250 0.007 TF:M02091_0 tf 1 Factor: E4F1; motif: RTGACGTAAC; match class: 0 1 Q96GY3 472 4.31e-02 3000 4 3 0.750 0.001 TF:M04238_0 tf 1 Factor: FOXD2; motif: NRNWAATATTTAYN; match class: 0 1 P10243,Q52LA3,Q96GY3 472 4.50e-02 5864 4 4 1.000 0.001 TF:M02070_1 tf 1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 4.66e-02 5915 4 4 1.000 0.001 TF:M00348_1 tf 1 Factor: GATA-2; motif: NNWGATAASA; match class: 1 1 Q5TKA1,P10243,Q52LA3,Q96GY3 472 4.69e-02 152 4 1 0.250 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q52LA3 472 4.69e-02 152 4 1 0.250 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q52LA3 472 4.69e-02 152 4 1 0.250 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q52LA3 472 4.69e-02 152 4 1 0.250 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q52LA3 472 4.72e-02 153 4 1 0.250 0.007 TF:M05731_0 tf 1 Factor: ZNF660; motif: NGGGGGGAACSM; match class: 0 1 P10243 472 4.73e-02 3103 4 3 0.750 0.001 TF:M02075_0 tf 1 Factor: PDEF; motif: MCCGGATNTN; match class: 0 1 Q5TKA1,Q52LA3,Q96GY3 472 4.76e-02 3109 4 3 0.750 0.001 TF:M00809_1 tf 1 Factor: FOX; motif: KWTTGTTTRTTTW; match class: 1 1 Q5TKA1,P10243,Q96GY3 472 4.90e-02 3143 4 3 0.750 0.001 TF:M01744_0 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 0 1 Q5TKA1,P10243,Q96GY3 472 4.97e-02 161 4 1 0.250 0.006 TF:M03892_1 tf 1 Factor: VDR:RXR-alpha; motif: RRGGTCAN; match class: 1 1 Q5TKA1 472 5.00e-02 2 4 1 0.250 0.500 CORUM:839 cor 1 LIN9-BMYB complex 1 Q5TKA1 472 5.00e-02 86 4 1 0.250 0.012 REAC:211000 rea 1 Gene Silencing by RNA 1 P10243 472 5.00e-02 679 4 3 0.750 0.004 GO:0051726 BP 1 regulation of cell cycle 1 Q5TKA1,Q52LA3,Q96GY3 473 1.85e-10 229 6 6 1.000 0.026 GO:0006364 BP 1 rRNA processing 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.00e-10 232 6 6 1.000 0.026 GO:0016072 BP 1 rRNA metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 4.58e-10 200 6 6 1.000 0.030 REAC:72312 rea 1 rRNA processing 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 5.99e-10 278 6 6 1.000 0.022 GO:0042254 BP 1 ribosome biogenesis 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.15e-09 27 6 4 0.667 0.148 GO:0071339 CC 1 MLL1 complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 1.15e-09 27 6 4 0.667 0.148 GO:0044665 CC 1 MLL1/2 complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 2.33e-09 348 6 6 1.000 0.017 GO:0034470 BP 1 ncRNA processing 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 4.93e-09 394 6 6 1.000 0.015 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.89e-08 492 6 6 1.000 0.012 GO:0034660 BP 1 ncRNA metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 5.30e-08 68 6 4 0.667 0.059 GO:0035097 CC 1 histone methyltransferase complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 1.44e-07 87 6 4 0.667 0.046 GO:0034708 CC 1 methyltransferase complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 2.43e-07 752 6 6 1.000 0.008 GO:0006396 BP 1 RNA processing 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 5.08e-07 24 6 3 0.500 0.125 GO:0000470 BP 1 maturation of LSU-rRNA 1 Q9Y4W2,Q9NXF1,Q5SY16 473 8.53e-06 60 6 3 0.500 0.050 GO:0042273 BP 1 ribosomal large subunit biogenesis 1 Q9Y4W2,Q9NXF1,Q5SY16 473 3.99e-05 11 6 2 0.333 0.182 GO:0000478 BP 1 endonucleolytic cleavage involved in rRNA processing 1 Q9Y4W2,Q5SY16 473 7.07e-05 1932 6 6 1.000 0.003 GO:0044085 BP 1 cellular component biogenesis 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 8.19e-05 1485 6 6 1.000 0.004 REAC:74160 rea 1 Gene Expression 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 8.70e-05 16 6 2 0.333 0.125 GO:0090502 BP 1 RNA phosphodiester bond hydrolysis, endonucleolytic 1 Q9Y4W2,Q5SY16 473 1.52e-04 21 6 2 0.333 0.095 GO:0000469 BP 1 cleavage involved in rRNA processing 1 Q9Y4W2,Q5SY16 473 1.85e-04 521 6 4 0.667 0.008 GO:0044451 CC 1 nucleoplasm part 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 2.73e-04 28 6 2 0.333 0.071 GO:0030687 CC 1 preribosome, large subunit precursor 1 Q9Y4W2,Q9NXF1 473 3.14e-04 30 6 2 0.333 0.067 GO:0000460 BP 1 maturation of 5.8S rRNA 1 Q9Y4W2,Q5SY16 473 3.56e-04 2529 6 6 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.76e-04 624 6 4 0.667 0.006 GO:1990234 CC 1 transferase complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 4.48e-04 2627 6 6 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 7.71e-04 2189 6 5 0.833 0.002 TF:M01306_0 tf 1 Factor: ZABC1; motif: ATTCCNAC; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q9H4L4,Q5SY16 473 8.11e-04 48 6 2 0.333 0.042 GO:0090501 BP 1 RNA phosphodiester bond hydrolysis 1 Q9Y4W2,Q5SY16 473 8.65e-04 2931 6 6 1.000 0.002 GO:0031981 CC 1 nuclear lumen 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.02e-03 3013 6 6 1.000 0.002 GO:0090304 BP 1 nucleic acid metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.12e-03 3058 6 6 1.000 0.002 GO:0010467 BP 1 gene expression 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.38e-03 3168 6 6 1.000 0.002 GO:0044428 CC 1 nuclear part 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.41e-03 3 6 1 0.167 0.333 TF:M05944_1 tf 1 Factor: ZNF552; motif: NWTTGCTGRMGA; match class: 1 1 Q5SY16 473 1.68e-03 1 6 1 0.167 1.000 GO:0097344 CC 1 Rix1 complex 1 Q9NXF1 473 1.68e-03 1 6 1 0.167 1.000 GO:0000448 BP 1 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q5SY16 473 1.68e-03 69 6 2 0.333 0.029 GO:0030684 CC 1 preribosome 1 Q9Y4W2,Q9NXF1 473 2.27e-03 3443 6 6 1.000 0.002 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.67e-03 1033 6 4 0.667 0.004 GO:1902494 CC 1 catalytic complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 473 2.73e-03 3 6 1 0.167 0.333 REAC:8849473 rea 1 PTK6 Expression 1 Q8IZL8 473 2.75e-03 3554 6 6 1.000 0.002 GO:0046483 BP 1 heterocycle metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.78e-03 3561 6 6 1.000 0.002 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.78e-03 3561 6 6 1.000 0.002 GO:0031974 CC 1 membrane-enclosed lumen 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.78e-03 3561 6 6 1.000 0.002 GO:0043233 CC 1 organelle lumen 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.78e-03 3561 6 6 1.000 0.002 GO:0070013 CC 1 intracellular organelle lumen 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.40e-03 3681 6 6 1.000 0.002 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.60e-03 202 6 2 0.333 0.010 TF:M06128_0 tf 1 Factor: ZNF3; motif: NGGGCCAACCGM; match class: 0 1 Q9NXF1,Q5SY16 473 3.84e-03 653 6 3 0.500 0.005 HPA:026010_03 hpa 1 ovary; follicle cells[Uncertain,High] 1 Q9Y4W2,Q9BV38,Q8IZL8 473 4.72e-03 116 6 2 0.333 0.017 GO:0090305 BP 1 nucleic acid phosphodiester bond hydrolysis 1 Q9Y4W2,Q5SY16 473 5.17e-03 3948 6 6 1.000 0.002 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 5.59e-03 1884 6 4 0.667 0.002 TF:M01248_0 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 0 1 Q9BV38,Q9NXF1,Q8IZL8,Q5SY16 473 5.70e-03 4013 6 6 1.000 0.001 GO:0071840 BP 1 cellular component organization or biogenesis 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 5.72e-03 217 6 2 0.333 0.009 HPA:011010_13 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 6.07e-03 3370 6 5 0.833 0.001 TF:M00192_0 tf 1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q9H4L4,Q5SY16 473 6.57e-03 233 6 2 0.333 0.009 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 6.70e-03 4 6 1 0.167 0.250 GO:0051731 MF 1 polynucleotide 5'-hydroxyl-kinase activity 1 Q5SY16 473 8.21e-03 4264 6 6 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 8.38e-03 5 6 1 0.167 0.200 GO:0030174 BP 1 regulation of DNA-dependent DNA replication initiation 1 Q9NXF1 473 9.06e-03 3669 6 5 0.833 0.001 TF:M05432_0 tf 1 Factor: ZSCAN18; motif: TRRCGRCGNMCC; match class: 0 1 Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 9.06e-03 275 6 2 0.333 0.007 HPA:026010_13 hpa 1 ovary; follicle cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 9.86e-03 21 6 1 0.167 0.048 TF:M05723_0 tf 1 Factor: ZNF19; motif: NTGGGAAACTGC; match class: 0 1 Q9H4L4 473 9.88e-03 645 6 3 0.500 0.005 GO:0005730 CC 1 nucleolus 1 Q8IZL8,Q9H4L4,Q5SY16 473 1.03e-02 4430 6 6 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.13e-02 24 6 1 0.167 0.042 TF:M05972_0 tf 1 Factor: ZNF701; motif: NTGGGGTGAARA; match class: 0 1 Q9H4L4 473 1.17e-02 25 6 1 0.167 0.040 TF:M06485_0 tf 1 Factor: ZNF808; motif: NGGKGAAATAGA; match class: 0 1 Q9Y4W2 473 1.34e-02 8 6 1 0.167 0.125 GO:0016929 MF 1 SUMO-specific protease activity 1 Q9H4L4 473 1.34e-02 8 6 1 0.167 0.125 GO:0016926 BP 1 protein desumoylation 1 Q9H4L4 473 1.40e-02 345 6 2 0.333 0.006 HPA:035010_13 hpa 1 skin 1; Langerhans[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 1.43e-02 349 6 2 0.333 0.006 HPA:019010_13 hpa 1 kidney; cells in glomeruli[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 1.45e-02 31 6 1 0.167 0.032 TF:M00767_0 tf 1 Factor: FXR; motif: GGGTBAATRACCY; match class: 0 1 Q8IZL8 473 1.50e-02 357 6 2 0.333 0.006 HPA:034010_13 hpa 1 skeletal muscle; myocytes[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 1.51e-02 9 6 1 0.167 0.111 GO:0000463 BP 1 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q5SY16 473 1.51e-02 9 6 1 0.167 0.111 GO:0071391 BP 1 cellular response to estrogen stimulus 1 Q8IZL8 473 1.59e-02 434 6 2 0.333 0.005 TF:M04298_1 tf 1 Factor: Cdx-2; motif: GYMATAAAA; match class: 1 1 Q9NXF1,Q5SY16 473 1.59e-02 1275 6 3 0.500 0.002 TF:M04351_1 tf 1 Factor: HOXC10; motif: GYMATWAAAN; match class: 1 1 Q9Y4W2,Q9NXF1,Q5SY16 473 1.61e-02 6396 6 6 1.000 0.001 TF:M07387_0 tf 1 Factor: LRF; motif: NGNSACCCMCN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.67e-02 10 6 1 0.167 0.100 GO:0000479 BP 1 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q5SY16 473 1.73e-02 37 6 1 0.167 0.027 TF:M06762_0 tf 1 Factor: ZNF222; motif: NGGTCRAAACGA; match class: 0 1 Q9H4L4 473 1.77e-02 2576 6 4 0.667 0.002 TF:M04616_0 tf 1 Factor: islet1; motif: NGNTAATG; match class: 0 1 Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 1.81e-02 394 6 2 0.333 0.005 HPA:011010_03 hpa 1 endometrium 1; cells in endometrial stroma[Uncertain,High] 1 Q9Y4W2,Q8IZL8 473 1.90e-02 404 6 2 0.333 0.005 HPA:035030_13 hpa 1 skin 1; keratinocytes[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 1.97e-02 240 6 2 0.333 0.008 GO:0003682 MF 1 chromatin binding 1 Q9NXF1,Q8IZL8 473 2.00e-02 416 6 2 0.333 0.005 HPA:027020_13 hpa 1 pancreas; islets of Langerhans[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 2.02e-02 493 6 2 0.333 0.004 TF:M00737_1 tf 1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 1 Q9BV38,Q8IZL8 473 2.05e-02 496 6 2 0.333 0.004 TF:M02033_0 tf 1 Factor: TCF-4; motif: ATCAAAGNNN; match class: 0 1 Q9NXF1,Q8IZL8 473 2.11e-02 4990 6 6 1.000 0.001 GO:0044260 BP 1 cellular macromolecule metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.24e-02 48 6 1 0.167 0.021 TF:M06308_1 tf 1 Factor: ZNF468; motif: GSATAAWAAGA; match class: 1 1 Q9NXF1 473 2.37e-02 454 6 2 0.333 0.004 HPA:008020_13 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 2.47e-02 53 6 1 0.167 0.019 TF:M01241_1 tf 1 Factor: BEN; motif: CWGCGAYA; match class: 1 1 Q9BV38 473 2.59e-02 476 6 2 0.333 0.004 HPA:017010_13 hpa 1 heart muscle; myocytes[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 2.60e-02 4605 6 5 0.833 0.001 TF:M02034_1 tf 1 Factor: TTF-1; motif: NNNCNCTTGASNNN; match class: 1 1 Q9Y4W2,Q9BV38,Q8IZL8,Q9H4L4,Q5SY16 473 2.67e-02 16 6 1 0.167 0.062 GO:0035327 CC 1 transcriptionally active chromatin 1 Q8IZL8 473 2.76e-02 6998 6 6 1.000 0.001 TF:M07301_0 tf 1 Factor: NF-AT3; motif: NGGAAAAN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 2.89e-02 505 6 2 0.333 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 2.93e-02 600 6 2 0.333 0.003 TF:M00177_0 tf 1 Factor: CREB; motif: NSTGACGTAANN; match class: 0 1 Q9Y4W2,Q9H4L4 473 3.01e-02 18 6 1 0.167 0.056 GO:0043627 BP 1 response to estrogen 1 Q8IZL8 473 3.01e-02 18 6 1 0.167 0.056 GO:0000466 BP 1 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 Q5SY16 473 3.02e-02 609 6 2 0.333 0.003 TF:M04297_1 tf 1 Factor: CDX1; motif: GYMATAAAA; match class: 1 1 Q9NXF1,Q5SY16 473 3.02e-02 4759 6 5 0.833 0.001 TF:M07370_1 tf 1 Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q5SY16 473 3.09e-02 5319 6 6 1.000 0.001 GO:0043170 BP 1 macromolecule metabolic process 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.16e-02 68 6 1 0.167 0.015 TF:M06464_0 tf 1 Factor: znf679; motif: GGGCATGGCGKC; match class: 0 1 Q9BV38 473 3.17e-02 531 6 2 0.333 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.18e-02 1645 6 3 0.500 0.002 TF:M07420_0 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 0 1 Q9BV38,Q8IZL8,Q9H4L4 473 3.21e-02 69 6 1 0.167 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 Q9NXF1 473 3.24e-02 7188 6 6 1.000 0.001 TF:M01307_0 tf 1 Factor: Oct3; motif: NATGCAANNN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.24e-02 537 6 2 0.333 0.004 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.26e-02 635 6 2 0.333 0.003 TF:M04141_1 tf 1 Factor: TEAD1; motif: NRCATTCCWN; match class: 1 1 Q9Y4W2,Q9NXF1 473 3.45e-02 555 6 2 0.333 0.004 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 Q9Y4W2,Q8IZL8 473 3.46e-02 1440 6 3 0.500 0.002 HPA:012020_03 hpa 1 endometrium 2; glandular cells[Uncertain,High] 1 Q9Y4W2,Q9BV38,Q8IZL8 473 3.48e-02 75 6 1 0.167 0.013 TF:M06914_0 tf 1 Factor: ZNF236; motif: NGWWTTTGCGMA; match class: 0 1 Q5SY16 473 3.52e-02 1707 6 3 0.500 0.002 TF:M00738_0 tf 1 Factor: E2F-4:DP-1; motif: TTTSGCGC; match class: 0 1 Q9BV38,Q8IZL8,Q9H4L4 473 3.55e-02 564 6 2 0.333 0.004 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.55e-02 564 6 2 0.333 0.004 HPA:004020_13 hpa 1 breast; glandular cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.60e-02 3143 6 4 0.667 0.001 TF:M01744_0 tf 1 Factor: REX1; motif: AANATGGCKGCN; match class: 0 1 Q9Y4W2,Q9BV38,Q8IZL8,Q5SY16 473 3.74e-02 580 6 2 0.333 0.003 HPA:046010_13 hpa 1 tonsil; germinal center cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.80e-02 82 6 1 0.167 0.012 TF:M03980_0 tf 1 Factor: ETV2; motif: AACCGGAAATR; match class: 0 1 Q9NXF1 473 3.82e-02 7386 6 6 1.000 0.001 TF:M02078_0 tf 1 Factor: SPI1; motif: NGRGGAAGTN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 3.85e-02 694 6 2 0.333 0.003 TF:M03973_0 tf 1 Factor: ELK4; motif: ACCGGAARTN; match class: 0 1 Q9Y4W2,Q9NXF1 473 3.85e-02 589 6 2 0.333 0.003 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 3.94e-02 596 6 2 0.333 0.003 HPA:012020_13 hpa 1 endometrium 2; glandular cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.03e-02 87 6 1 0.167 0.011 TF:M01724_0 tf 1 Factor: T3RALPHA; motif: NNTSRGGTCAN; match class: 0 1 Q8IZL8 473 4.08e-02 88 6 1 0.167 0.011 TF:M06440_0 tf 1 Factor: ZNF493; motif: KGGGAAKAAGGA; match class: 0 1 Q9NXF1 473 4.08e-02 88 6 1 0.167 0.011 TF:M00742_0 tf 1 Factor: HFH4; motif: AWKTGTTTGTTTA; match class: 0 1 Q5SY16 473 4.08e-02 608 6 2 0.333 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q9Y4W2,Q8IZL8 473 4.14e-02 722 6 2 0.333 0.003 TF:M00050_1 tf 1 Factor: E2F; motif: TTTSGCGC; match class: 1 1 Q9BV38,Q8IZL8 473 4.17e-02 3279 6 4 0.667 0.001 TF:M04297_0 tf 1 Factor: CDX1; motif: GYMATAAAA; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q5SY16 473 4.25e-02 7520 6 6 1.000 0.001 TF:M01072_0 tf 1 Factor: HIC1; motif: NSNNNNTGCCCSSNN; match class: 0 1 Q9Y4W2,Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 4.28e-02 624 6 2 0.333 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.30e-02 625 6 2 0.333 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.30e-02 5147 6 5 0.833 0.001 TF:M00630_0 tf 1 Factor: FOXM1; motif: ARATKGAST; match class: 0 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4,Q5SY16 473 4.41e-02 634 6 2 0.333 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.44e-02 96 6 1 0.167 0.010 TF:M05944_0 tf 1 Factor: ZNF552; motif: NWTTGCTGRMGA; match class: 0 1 Q5SY16 473 4.44e-02 96 6 1 0.167 0.010 TF:M06176_1 tf 1 Factor: ZNF45; motif: NRGGAAKRAAGA; match class: 1 1 Q9H4L4 473 4.45e-02 751 6 2 0.333 0.003 TF:M00739_1 tf 1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 1 Q9BV38,Q8IZL8 473 4.49e-02 97 6 1 0.167 0.010 TF:M07420_1 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 1 1 Q9H4L4 473 4.62e-02 650 6 2 0.333 0.003 HPA:046030_13 hpa 1 tonsil; squamous epithelial cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.67e-02 101 6 1 0.167 0.010 TF:M06317_0 tf 1 Factor: ZNF829; motif: KGGGSCARACGC; match class: 0 1 Q9Y4W2 473 4.76e-02 661 6 2 0.333 0.003 HPA:038010_03 hpa 1 smooth muscle; smooth muscle cells[Uncertain,High] 1 Q9Y4W2,Q8IZL8 473 4.80e-02 3414 6 4 0.667 0.001 TF:M01175_1 tf 1 Factor: CKROX; motif: SCCCTCCCC; match class: 1 1 Q9BV38,Q9NXF1,Q8IZL8,Q9H4L4 473 4.84e-02 5285 6 5 0.833 0.001 TF:M02052_1 tf 1 Factor: EHF; motif: CSCGGAARTN; match class: 1 1 Q9Y4W2,Q9BV38,Q9NXF1,Q9H4L4,Q5SY16 473 4.85e-02 1635 6 3 0.500 0.002 HPA:039020_02 hpa 1 soft tissue 1; chondrocytes[Uncertain,Medium] 1 Q9Y4W2,Q8IZL8,Q9H4L4 473 4.94e-02 674 6 2 0.333 0.003 HPA:044010_13 hpa 1 testis; Leydig cells[Supportive,High] 1 Q9Y4W2,Q8IZL8 473 4.99e-02 799 6 2 0.333 0.003 TF:M07371_0 tf 1 Factor: ZEB; motif: NNNCAGGTGNSN; match class: 0 1 Q8IZL8,Q9H4L4 473 5.00e-02 30 6 1 0.167 0.033 GO:0006270 BP 1 DNA replication initiation 1 Q9NXF1 473 5.00e-02 422 6 3 0.500 0.007 MI:hsa-miR-566 mi 1 MI:hsa-miR-566 1 Q9BV38,Q8IZL8,Q5SY16 473 5.00e-02 56 6 1 0.167 0.018 REAC:8848021 rea 1 Signaling by PTK6 1 Q8IZL8 473 5.00e-02 26 6 4 0.667 0.154 CORUM:5386 cor 1 MLL1-WDR5 complex 1 Q9Y4W2,Q9NXF1,Q8IZL8,Q9H4L4 474 7.43e-04 36 4 2 0.500 0.056 GO:0018024 MF 1 histone-lysine N-methyltransferase activity 1 Q03112,Q9HAZ2 474 1.11e-03 44 4 2 0.500 0.045 GO:0016279 MF 1 protein-lysine N-methyltransferase activity 1 Q03112,Q9HAZ2 474 1.17e-03 45 4 2 0.500 0.044 GO:0016278 MF 1 lysine N-methyltransferase activity 1 Q03112,Q9HAZ2 474 1.33e-03 48 4 2 0.500 0.042 GO:0042054 MF 1 histone methyltransferase activity 1 Q03112,Q9HAZ2 474 2.01e-03 42 4 2 0.500 0.048 REAC:3214841 rea 1 PKMTs methylate histone lysines 1 Q03112,Q9HAZ2 474 2.68e-03 68 4 2 0.500 0.029 GO:0008276 MF 1 protein methyltransferase activity 1 Q03112,Q9HAZ2 474 3.00e-03 72 4 2 0.500 0.028 GO:0008170 MF 1 N-methyltransferase activity 1 Q03112,Q9HAZ2 474 5.58e-03 1 4 1 0.250 1.000 OMIM:615373 omi 1 LEFT VENTRICULAR NONCOMPACTION 8; LVNC8CARDIOMYOPATHY, DILATED, 1LL, INCLUDED; CMD1LL, INCLUDED 1 Q9HAZ2 474 6.89e-03 3 4 1 0.250 0.333 HP:0006897 hp 1 Cranial nerve VI palsy 1 Q9HAZ2 474 7.75e-03 619 4 3 0.750 0.005 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 Q03112,O95238,Q9HAZ2 474 7.90e-03 623 4 3 0.750 0.005 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 Q03112,O95238,Q9HAZ2 474 8.24e-03 632 4 3 0.750 0.005 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 Q03112,O95238,Q9HAZ2 474 8.48e-03 121 4 2 0.500 0.017 GO:0008757 MF 1 S-adenosylmethionine-dependent methyltransferase activity 1 Q03112,Q9HAZ2 474 9.18e-03 4 4 1 0.250 0.250 HP:0010316 hp 1 Ebstein's anomaly of the tricuspid valve 1 Q9HAZ2 474 9.67e-03 667 4 3 0.750 0.004 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 Q03112,O95238,Q9HAZ2 474 1.15e-02 5 4 1 0.250 0.200 HP:0010865 hp 1 Oppositional defiant disorder 1 Q9HAZ2 474 1.22e-02 145 4 2 0.500 0.014 GO:0008168 MF 1 methyltransferase activity 1 Q03112,Q9HAZ2 474 1.35e-02 153 4 2 0.500 0.013 GO:0016741 MF 1 transferase activity, transferring one-carbon groups 1 Q03112,Q9HAZ2 474 1.38e-02 6 4 1 0.250 0.167 HP:0001734 hp 1 Annular pancreas 1 Q9HAZ2 474 1.38e-02 753 4 3 0.750 0.004 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 Q03112,O95238,Q9HAZ2 474 1.44e-02 4 4 1 0.250 0.250 TF:M03945_1 tf 1 Factor: CENPB; motif: CCCGCNTNNNRCGAA; match class: 1 1 Q9HAZ2 474 1.45e-02 765 4 3 0.750 0.004 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 Q03112,O95238,Q9HAZ2 474 1.60e-02 7 4 1 0.250 0.143 HP:0000892 hp 1 Bifid ribs 1 Q9HAZ2 474 1.62e-02 794 4 3 0.750 0.004 GO:0010558 BP 1 negative regulation of macromolecule biosynthetic process 1 Q03112,O95238,Q9HAZ2 474 1.79e-02 822 4 3 0.750 0.004 GO:0031327 BP 1 negative regulation of cellular biosynthetic process 1 Q03112,O95238,Q9HAZ2 474 1.83e-02 8 4 1 0.250 0.125 HP:0010722 hp 1 Asymmetry of the ears 1 Q9HAZ2 474 1.87e-02 834 4 3 0.750 0.004 GO:0009890 BP 1 negative regulation of biosynthetic process 1 Q03112,O95238,Q9HAZ2 474 1.99e-02 852 4 3 0.750 0.004 GO:0051172 BP 1 negative regulation of nitrogen compound metabolic process 1 Q03112,O95238,Q9HAZ2 474 2.05e-02 861 4 3 0.750 0.003 GO:0010629 BP 1 negative regulation of gene expression 1 Q03112,O95238,Q9HAZ2 474 2.52e-02 11 4 1 0.250 0.091 HP:0002188 hp 1 Delayed CNS myelination 1 Q9HAZ2 474 2.52e-02 11 4 1 0.250 0.091 HP:0002616 hp 1 Aortic root dilatation 1 Q9HAZ2 474 2.74e-02 12 4 1 0.250 0.083 HP:0011664 hp 1 Left ventricular noncompaction cardiomyopathy 1 Q9HAZ2 474 3.18e-02 7 4 1 0.250 0.143 GO:0050873 BP 1 brown fat cell differentiation 1 Q9HAZ2 474 3.42e-02 15 4 1 0.250 0.067 HP:0011228 hp 1 Horizontal eyebrow 1 Q9HAZ2 474 3.42e-02 15 4 1 0.250 0.067 HP:0012817 hp 1 Noncompaction cardiomyopathy 1 Q9HAZ2 474 3.42e-02 15 4 1 0.250 0.067 HP:0000176 hp 1 Submucous cleft hard palate 1 Q9HAZ2 474 3.42e-02 15 4 1 0.250 0.067 HP:0410005 hp 1 Cleft hard palate 1 Q9HAZ2 474 3.60e-02 10 4 1 0.250 0.100 TF:M00721_1 tf 1 Factor: CACCC-binding; motif: CANCCNNWGGGTGDGG; match class: 1 1 Q9HAZ2 474 3.65e-02 16 4 1 0.250 0.062 HP:0000902 hp 1 Rib fusion 1 Q9HAZ2 474 3.65e-02 16 4 1 0.250 0.062 HP:0000851 hp 1 Congenital hypothyroidism 1 Q9HAZ2 474 3.87e-02 17 4 1 0.250 0.059 HP:0100559 hp 1 Lower limb asymmetry 1 Q9HAZ2 474 4.01e-02 313 4 2 0.500 0.006 TF:M03553_1 tf 1 Factor: KLF3; motif: CCMCACCCNG; match class: 1 1 Q03112,Q96GV9 474 4.10e-02 18 4 1 0.250 0.056 HP:0006956 hp 1 Dilation of lateral ventricles 1 Q9HAZ2 474 4.10e-02 18 4 1 0.250 0.056 HP:0001655 hp 1 Patent foramen ovale 1 Q9HAZ2 474 4.16e-02 114 4 1 0.250 0.009 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q03112 474 4.33e-02 19 4 1 0.250 0.053 HP:0002101 hp 1 Abnormal lung lobation 1 Q9HAZ2 474 4.41e-02 121 4 1 0.250 0.008 HPA:039020_13 hpa 1 soft tissue 1; chondrocytes[Supportive,High] 1 Q03112 474 4.55e-02 20 4 1 0.250 0.050 HP:0001107 hp 1 Ocular albinism 1 Q9HAZ2 474 4.55e-02 20 4 1 0.250 0.050 HP:0410004 hp 1 Cleft secondary palate 1 Q9HAZ2 474 4.77e-02 131 4 1 0.250 0.008 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 Q03112 474 4.78e-02 21 4 1 0.250 0.048 HP:0003416 hp 1 Spinal canal stenosis 1 Q9HAZ2 474 5.00e-02 211 4 2 0.500 0.009 REAC:4839726 rea 1 Chromatin organization 1 Q03112,Q9HAZ2 474 5.00e-02 211 4 2 0.500 0.009 REAC:3247509 rea 1 Chromatin modifying enzymes 1 Q03112,Q9HAZ2 474 5.00e-02 22 4 1 0.250 0.045 HP:0004383 hp 1 Hypoplastic left heart 1 Q9HAZ2 474 5.00e-02 22 4 1 0.250 0.045 HP:0045017 hp 1 Congenital malformation of the left heart 1 Q9HAZ2 474 5.00e-02 350 4 2 0.500 0.006 TF:M00721_0 tf 1 Factor: CACCC-binding; motif: CANCCNNWGGGTGDGG; match class: 0 1 Q03112,Q9HAZ2 474 5.00e-02 11 4 1 0.250 0.091 GO:0043457 BP 1 regulation of cellular respiration 1 Q9HAZ2 474 5.00e-02 11 4 1 0.250 0.091 GO:0071425 BP 1 hematopoietic stem cell proliferation 1 Q03112 475 1.45e-03 786 4 3 0.750 0.004 HPA:022020_03 hpa 1 lung; pneumocytes[Uncertain,High] 1 P28288,Q86UP2,Q9BTV4 475 5.46e-03 333 4 2 0.500 0.006 HPA:020010_13 hpa 1 lateral ventricle; glial cells[Supportive,High] 1 P28288,Q86UP2 475 5.72e-03 341 4 2 0.500 0.006 HPA:007020_13 hpa 1 cerebral cortex; glial cells[Supportive,High] 1 P28288,Q86UP2 475 6.28e-03 1 4 1 0.250 1.000 OMIM:616278 omi 1 BILE ACID SYNTHESIS DEFECT, CONGENITAL, 5; CBAS5 1 P28288 475 6.28e-03 1 4 1 0.250 1.000 OMIM:151050 omi 1 LENZ-MAJEWSKI HYPEROSTOTIC DWARFISM; LMHD;;LENZ-MAJEWSKI SYNDROME 1 P48651 475 6.28e-03 1 4 1 0.250 1.000 OMIM:614302 omi 1 EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7 1 Q9BTV4 475 6.28e-03 1 4 1 0.250 1.000 OMIM:604400 omi 1 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 5; ARVD5;;ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY 5; ARVC5 1 Q9BTV4 475 6.64e-03 368 4 2 0.500 0.005 HPA:022020_13 hpa 1 lung; pneumocytes[Supportive,High] 1 P28288,Q86UP2 475 7.93e-03 403 4 2 0.500 0.005 HPA:007010_03 hpa 1 cerebral cortex; endothelial cells[Uncertain,High] 1 Q86UP2,Q9BTV4 475 8.84e-03 442 4 2 0.500 0.005 MI:hsa-miR-770-5p mi 1 MI:hsa-miR-770-5p 1 P28288,P48651 475 9.11e-03 2 4 1 0.250 0.500 REAC:1483101 rea 1 Synthesis of PS 1 P48651 475 9.43e-03 12 4 1 0.250 0.083 TF:M04353_1 tf 1 Factor: HOXC11; motif: NGTCGTAAAAN; match class: 1 1 Q9BTV4 475 9.92e-03 166 4 3 0.750 0.018 HP:0009811 hp 1 Abnormality of the elbow 1 P28288,P48651,Q9BTV4 475 1.01e-02 474 4 2 0.500 0.004 MI:hsa-miR-369-3p mi 1 MI:hsa-miR-369-3p 1 P28288,Q86UP2 475 1.16e-02 489 4 2 0.500 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P28288,Q86UP2 475 1.38e-02 556 4 2 0.500 0.004 MI:hsa-miR-15a mi 1 MI:hsa-miR-15a 1 Q86UP2,P48651 475 1.41e-02 18 4 1 0.250 0.056 TF:M05735_0 tf 1 Factor: ZNF390; motif: NCGTSTAACAWC; match class: 0 1 Q86UP2 475 1.54e-02 567 4 2 0.500 0.004 HPA:030010_13 hpa 1 prostate; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 1.60e-02 195 4 3 0.750 0.015 HP:0100360 hp 1 Contractures of the joints of the upper limbs 1 P28288,P48651,Q9BTV4 475 1.60e-02 601 4 2 0.500 0.003 MI:hsa-miR-200c mi 1 MI:hsa-miR-200c 1 P28288,Q9BTV4 475 1.63e-02 1547 4 3 0.750 0.002 TF:M00040_0 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 0 1 P28288,P48651,Q9BTV4 475 1.63e-02 1547 4 3 0.750 0.002 TF:M00040_1 tf 1 Factor: ATF-2; motif: TTACGTAA; match class: 1 1 P28288,P48651,Q9BTV4 475 1.67e-02 1 4 1 0.250 1.000 HP:0005477 hp 1 Progressive sclerosis of skull base 1 P48651 475 1.70e-02 438 4 2 0.500 0.005 TF:M00466_0 tf 1 Factor: HIF1; motif: NGTACGTGCNGB; match class: 0 1 Q86UP2,P48651 475 1.85e-02 624 4 2 0.500 0.003 HPA:033010_13 hpa 1 seminal vesicle; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 1.86e-02 625 4 2 0.500 0.003 HPA:011020_13 hpa 1 endometrium 1; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 1.93e-02 1638 4 3 0.750 0.002 TF:M04339_0 tf 1 Factor: HOXA10; motif: NRTCRTAAAANN; match class: 0 1 Q86UP2,P48651,Q9BTV4 475 1.94e-02 639 4 2 0.500 0.003 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 P28288,Q86UP2 475 1.96e-02 25 4 1 0.250 0.040 TF:M04359_1 tf 1 Factor: HOXD11; motif: RTCGTAAAAN; match class: 1 1 Q9BTV4 475 2.01e-02 652 4 2 0.500 0.003 HPA:020010_03 hpa 1 lateral ventricle; glial cells[Uncertain,High] 1 P28288,Q86UP2 475 2.04e-02 26 4 1 0.250 0.038 TF:M00437_1 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 1 1 P48651 475 2.20e-02 682 4 2 0.500 0.003 HPA:007020_03 hpa 1 cerebral cortex; glial cells[Uncertain,High] 1 P28288,Q86UP2 475 2.20e-02 28 4 1 0.250 0.036 TF:M07218_1 tf 1 Factor: MEF-2A; motif: NKCTAAAAATAGMNN; match class: 1 1 Q86UP2 475 2.22e-02 3905 4 4 1.000 0.001 TF:M01593_0 tf 1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 0 1 P28288,Q86UP2,P48651,Q9BTV4 475 2.35e-02 2051 4 3 0.750 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 P28288,Q86UP2,Q9BTV4 475 2.37e-02 4237 4 4 1.000 0.001 HPA:035040_02 hpa 1 skin 1; melanocytes[Uncertain,Medium] 1 P28288,Q86UP2,P48651,Q9BTV4 475 2.51e-02 4 4 1 0.250 0.250 OMIM:607765 omi 1 Congenital Defects in Bile Acid Synthesis 1 P28288 475 2.65e-02 753 4 2 0.500 0.003 HPA:013010_13 hpa 1 epididymis; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 2.70e-02 55 4 2 0.500 0.036 HP:0002987 hp 1 Elbow flexion contracture 1 P48651,Q9BTV4 475 2.84e-02 781 4 2 0.500 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P28288,Q86UP2 475 3.13e-02 40 4 1 0.250 0.025 KEGG:02010 keg 1 ABC transporters 1 P28288 475 3.13e-02 5 4 1 0.250 0.200 OMIM:310300 omi 1 Emery-Dreifuss Muscular Dystrophy 1 Q9BTV4 475 3.15e-02 4263 4 4 1.000 0.001 TF:M04320_1 tf 1 Factor: EVX1; motif: NNTNATTANN; match class: 1 1 P28288,Q86UP2,P48651,Q9BTV4 475 3.21e-02 41 4 1 0.250 0.024 TF:M05663_0 tf 1 Factor: ZNF450; motif: NAGGGCCNGCKC; match class: 0 1 Q86UP2 475 3.25e-02 838 4 2 0.500 0.002 HPA:002010_13 hpa 1 appendix; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 3.34e-02 2 4 1 0.250 0.500 HP:0001043 hp 1 Prominent scalp veins 1 P48651 475 3.34e-02 2 4 1 0.250 0.500 HP:0006677 hp 1 Prolonged QRS complex 1 Q9BTV4 475 3.40e-02 858 4 2 0.500 0.002 HPA:009010_03 hpa 1 colon; endothelial cells[Uncertain,High] 1 Q86UP2,Q9BTV4 475 3.47e-02 633 4 2 0.500 0.003 TF:M04451_0 tf 1 Factor: VSX2; motif: CTAATTAN; match class: 0 1 P28288,P48651 475 3.47e-02 633 4 2 0.500 0.003 TF:M04451_1 tf 1 Factor: VSX2; motif: CTAATTAN; match class: 1 1 P28288,P48651 475 3.50e-02 871 4 2 0.500 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 P28288,Q86UP2 475 3.52e-02 874 4 2 0.500 0.002 HPA:015010_13 hpa 1 fallopian tube; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 3.52e-02 45 4 1 0.250 0.022 TF:M06639_0 tf 1 Factor: znf559; motif: NGKGCCGACCGC; match class: 0 1 P28288 475 3.73e-02 902 4 2 0.500 0.002 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P28288,Q86UP2 475 3.75e-02 3 4 1 0.250 0.333 GO:0005324 MF 1 long-chain fatty acid transporter activity 1 P28288 475 3.75e-02 3 4 1 0.250 0.333 GO:0071763 BP 1 nuclear membrane organization 1 Q9BTV4 475 3.77e-02 906 4 2 0.500 0.002 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P28288,Q86UP2 475 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 3.96e-02 930 4 2 0.500 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P28288,Q86UP2 475 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P28288,Q86UP2 475 4.03e-02 267 4 3 0.750 0.011 HP:0003121 hp 1 Limb joint contracture 1 P28288,P48651,Q9BTV4 475 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 P28288,Q86UP2 475 4.18e-02 958 4 2 0.500 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P28288,Q86UP2 475 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P28288,Q86UP2 475 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P28288,Q86UP2 475 4.34e-02 977 4 2 0.500 0.002 HPA:019020_13 hpa 1 kidney; cells in tubules[Supportive,High] 1 P28288,Q86UP2 475 4.35e-02 712 4 2 0.500 0.003 TF:M04316_1 tf 1 Factor: EN1; motif: NYAATTAN; match class: 1 1 P28288,P48651 475 4.35e-02 712 4 2 0.500 0.003 TF:M04425_1 tf 1 Factor: PDX1; motif: NYAATTAN; match class: 1 1 P28288,P48651 475 4.38e-02 7 4 1 0.250 0.143 OMIM:211600 omi 1 Progressive Familial Intrahepatic Cholestasis 1 P28288 475 4.48e-02 994 4 2 0.500 0.002 HPA:043010_13 hpa 1 stomach 2; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 4.49e-02 995 4 2 0.500 0.002 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P28288,Q86UP2 475 4.52e-02 726 4 2 0.500 0.003 TF:M04212_0 tf 1 Factor: HLF; motif: NNTTACRTAAYN; match class: 0 1 P28288,P48651 475 4.55e-02 1002 4 2 0.500 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P28288,Q86UP2 475 4.58e-02 731 4 2 0.500 0.003 TF:M04309_0 tf 1 Factor: DUXA; motif: NTRAYYTAATCAN; match class: 0 1 Q86UP2,P48651 475 4.71e-02 2236 4 3 0.750 0.001 TF:M04344_1 tf 1 Factor: HOXA2; motif: NNTMATTANN; match class: 1 1 P28288,Q86UP2,P48651 475 4.77e-02 131 4 1 0.250 0.008 HPA:040040_13 hpa 1 soft tissue 2; peripheral nerve[Supportive,High] 1 P28288 475 4.84e-02 2257 4 3 0.750 0.001 TF:M05725_1 tf 1 Factor: GATA-2; motif: KTAMCAR; match class: 1 1 P28288,Q86UP2,P48651 475 4.84e-02 2257 4 3 0.750 0.001 TF:M05445_1 tf 1 Factor: GATA-5; motif: TTAMCAR; match class: 1 1 P28288,Q86UP2,P48651 475 4.99e-02 764 4 2 0.500 0.003 TF:M04308_0 tf 1 Factor: DRGX; motif: NTAATYNAATTAN; match class: 0 1 Q86UP2,P48651 475 5.00e-02 5 4 1 0.250 0.200 CORUM:5269 cor 1 TNF-alpha/NF-kappa B signaling complex 8 1 Q86UP2 475 5.00e-02 3 4 1 0.250 0.333 HP:0005019 hp 1 Diaphyseal thickening 1 P48651 475 5.00e-02 11 4 1 0.250 0.091 REAC:5625970 rea 1 RHO GTPases activate KTN1 1 Q86UP2 475 5.00e-02 64 4 1 0.250 0.016 TF:M00237_0 tf 1 Factor: AhR:Arnt; motif: GRGKATYGCGTGMCWNSCC; match class: 0 1 P48651 475 5.00e-02 3 4 1 0.250 0.333 HP:0006152 hp 1 Proximal symphalangism of hands 1 P48651 475 5.00e-02 3 4 1 0.250 0.333 HP:0100264 hp 1 Proximal symphalangism 1 P48651 475 5.00e-02 8 4 1 0.250 0.125 OMIM:107970 omi 1 Familial Arrhythmogenic Right Ventricular Dysplasia 1 Q9BTV4 475 5.00e-02 3 4 1 0.250 0.333 HP:0001015 hp 1 Prominent superficial veins 1 P48651 475 5.00e-02 4 4 1 0.250 0.250 GO:0006659 BP 1 phosphatidylserine biosynthetic process 1 P48651 475 5.00e-02 4 4 1 0.250 0.250 GO:0042760 BP 1 very long-chain fatty acid catabolic process 1 P28288 476 6.58e-03 271 2 2 1.000 0.007 GO:0098641 MF 1 cadherin binding involved in cell-cell adhesion 1 Q7L1Q6,Q9Y6E2 476 6.78e-03 275 2 2 1.000 0.007 GO:0098632 MF 1 protein binding involved in cell-cell adhesion 1 Q7L1Q6,Q9Y6E2 476 6.88e-03 277 2 2 1.000 0.007 GO:0098631 MF 1 protein binding involved in cell adhesion 1 Q7L1Q6,Q9Y6E2 476 7.13e-03 282 2 2 1.000 0.007 GO:0045296 MF 1 cadherin binding 1 Q7L1Q6,Q9Y6E2 476 7.75e-03 294 2 2 1.000 0.007 GO:0005913 CC 1 cell-cell adherens junction 1 Q7L1Q6,Q9Y6E2 476 1.22e-02 369 2 2 1.000 0.005 GO:0050839 MF 1 cell adhesion molecule binding 1 Q7L1Q6,Q9Y6E2 476 1.42e-02 7 2 1 0.500 0.143 TF:M05874_1 tf 1 Factor: ZNF564; motif: KGGWHGTGAACM; match class: 1 1 Q7L1Q6 476 1.58e-02 420 2 2 1.000 0.005 GO:0005911 CC 1 cell-cell junction 1 Q7L1Q6,Q9Y6E2 476 1.62e-02 8 2 1 0.500 0.125 TF:M00078_0 tf 1 Factor: Evi-1; motif: WGAYAAGATAAGATAA; match class: 0 1 Q9Y6E2 476 3.04e-02 582 2 2 1.000 0.003 GO:0005912 CC 1 adherens junction 1 Q7L1Q6,Q9Y6E2 476 3.14e-02 591 2 2 1.000 0.003 GO:0070161 CC 1 anchoring junction 1 Q7L1Q6,Q9Y6E2 476 3.44e-02 17 2 1 0.500 0.059 TF:M06386_0 tf 1 Factor: ZNF836; motif: NGGTGAAGCCAG; match class: 0 1 Q7L1Q6 476 4.25e-02 21 2 1 0.500 0.048 TF:M06875_0 tf 1 Factor: ZNF224; motif: NTTGGAAAATGM; match class: 0 1 Q7L1Q6 476 4.36e-02 469 2 2 1.000 0.004 MI:hsa-let-7f mi 1 MI:hsa-let-7f 1 Q7L1Q6,Q9Y6E2 476 4.53e-02 478 2 2 1.000 0.004 MI:hsa-let-7c mi 1 MI:hsa-let-7c 1 Q7L1Q6,Q9Y6E2 476 4.55e-02 479 2 2 1.000 0.004 MI:hsa-let-7e mi 1 MI:hsa-let-7e 1 Q7L1Q6,Q9Y6E2 476 4.61e-02 482 2 2 1.000 0.004 MI:mmu-miR-464 mi 1 MI:mmu-miR-464 1 Q7L1Q6,Q9Y6E2 476 4.65e-02 484 2 2 1.000 0.004 MI:hsa-let-7d mi 1 MI:hsa-let-7d 1 Q7L1Q6,Q9Y6E2 476 5.00e-02 746 2 2 1.000 0.003 GO:0030054 CC 1 cell junction 1 Q7L1Q6,Q9Y6E2 476 5.00e-02 502 2 2 1.000 0.004 MI:hsa-let-7g mi 1 MI:hsa-let-7g 1 Q7L1Q6,Q9Y6E2 476 5.00e-02 793 2 2 1.000 0.003 TF:M00072_1 tf 1 Factor: CP2; motif: GCHCDAMCCAG; match class: 1 1 Q7L1Q6,Q9Y6E2 476 5.00e-02 29 2 1 0.500 0.034 CORUM:1183 cor 1 CDC5L complex 1 Q7L1Q6 477 4.13e-04 127 6 3 0.500 0.024 GO:0005788 CC 1 endoplasmic reticulum lumen 1 Q8IWF2,Q9NYU1,P39060 477 1.84e-03 525 6 3 0.500 0.006 MI:hsa-miR-219-5p mi 1 MI:hsa-miR-219-5p 1 Q8IWF2,Q9NYU1,Q7Z7M0 477 7.74e-03 66 6 2 0.333 0.030 GO:0006487 BP 1 protein N-linked glycosylation 1 Q9NYU1,Q495W5 477 7.97e-03 67 6 2 0.333 0.030 GO:0030433 BP 1 ER-associated ubiquitin-dependent protein catabolic process 1 Q8IWF2,Q9NYU1 477 8.45e-03 1 6 1 0.167 1.000 GO:0055113 BP 1 epiboly involved in gastrulation with mouth forming second 1 Q7Z7M0 477 9.05e-03 285 6 2 0.333 0.007 MI:hsa-miR-18a* mi 1 MI:hsa-miR-18a* 1 Q24JP5,Q7Z7M0 477 9.07e-03 933 6 4 0.667 0.004 GO:0005783 CC 1 endoplasmic reticulum 1 Q24JP5,Q8IWF2,Q9NYU1,P39060 477 1.12e-02 319 6 2 0.333 0.006 MI:hsa-miR-218-1* mi 1 MI:hsa-miR-218-1* 1 Q24JP5,Q7Z7M0 477 1.19e-02 82 6 2 0.333 0.024 GO:0036503 BP 1 ERAD pathway 1 Q8IWF2,Q9NYU1 477 1.40e-02 358 6 2 0.333 0.006 MI:mmu-miR-880 mi 1 MI:mmu-miR-880 1 Q7Z7M0,Q495W5 477 1.49e-02 369 6 2 0.333 0.005 MI:hsa-miR-532-3p mi 1 MI:hsa-miR-532-3p 1 Q7Z7M0,Q495W5 477 1.52e-02 373 6 2 0.333 0.005 MI:hsa-miR-412 mi 1 MI:hsa-miR-412 1 Q24JP5,Q7Z7M0 477 1.64e-02 388 6 2 0.333 0.005 MI:hsa-miR-616 mi 1 MI:hsa-miR-616 1 Q9NYU1,Q495W5 477 1.66e-02 391 6 2 0.333 0.005 MI:mmu-miR-678 mi 1 MI:mmu-miR-678 1 Q24JP5,Q9NYU1 477 1.69e-02 2 6 1 0.167 0.500 GO:0003980 MF 1 UDP-glucose:glycoprotein glucosyltransferase activity 1 Q9NYU1 477 1.69e-02 2 6 1 0.167 0.500 GO:0060971 BP 1 embryonic heart tube left/right pattern formation 1 Q7Z7M0 477 1.69e-02 2 6 1 0.167 0.500 GO:0042074 BP 1 cell migration involved in gastrulation 1 Q7Z7M0 477 1.71e-02 397 6 2 0.333 0.005 MI:mmu-miR-201 mi 1 MI:mmu-miR-201 1 Q24JP5,Q9NYU1 477 1.75e-02 402 6 2 0.333 0.005 MI:mmu-miR-546 mi 1 MI:mmu-miR-546 1 Q24JP5,Q7Z7M0 477 1.79e-02 406 6 2 0.333 0.005 MI:mmu-miR-468 mi 1 MI:mmu-miR-468 1 Q9NYU1,P39060 477 1.79e-02 407 6 2 0.333 0.005 MI:mmu-miR-705 mi 1 MI:mmu-miR-705 1 Q24JP5,P39060 477 1.86e-02 415 6 2 0.333 0.005 MI:hsa-miR-200b* mi 1 MI:hsa-miR-200b* 1 Q7Z7M0,Q495W5 477 1.92e-02 422 6 2 0.333 0.005 MI:hsa-miR-29b-1* mi 1 MI:hsa-miR-29b-1* 1 Q24JP5,Q9NYU1 477 1.98e-02 429 6 2 0.333 0.005 MI:hsa-miR-218 mi 1 MI:hsa-miR-218 1 Q9NYU1,Q7Z7M0 477 1.99e-02 430 6 2 0.333 0.005 MI:mmu-miR-686 mi 1 MI:mmu-miR-686 1 Q7Z7M0,Q495W5 477 2.02e-02 433 6 2 0.333 0.005 MI:hsa-miR-181a-2* mi 1 MI:hsa-miR-181a-2* 1 Q9NYU1,Q495W5 477 2.16e-02 449 6 2 0.333 0.004 MI:hsa-miR-591 mi 1 MI:hsa-miR-591 1 Q24JP5,Q495W5 477 2.35e-02 2260 6 5 0.833 0.002 GO:0012505 CC 1 endomembrane system 1 Q24JP5,Q8IWF2,Q9NYU1,P39060,Q495W5 477 2.36e-02 5782 6 6 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 Q24JP5,Q8IWF2,Q9NYU1,Q7Z7M0,P39060,Q495W5 477 2.43e-02 478 6 2 0.333 0.004 MI:hsa-miR-421 mi 1 MI:hsa-miR-421 1 Q24JP5,Q9NYU1 477 2.44e-02 479 6 2 0.333 0.004 MI:hsa-miR-369-5p mi 1 MI:hsa-miR-369-5p 1 Q24JP5,Q9NYU1 477 2.48e-02 483 6 2 0.333 0.004 MI:hsa-miR-95 mi 1 MI:hsa-miR-95 1 Q24JP5,Q9NYU1 477 2.53e-02 3 6 1 0.167 0.333 GO:0001702 BP 1 gastrulation with mouth forming second 1 Q7Z7M0 477 2.53e-02 3 6 1 0.167 0.333 GO:0097155 BP 1 fasciculation of sensory neuron axon 1 Q7Z7M0 477 2.67e-02 502 6 2 0.333 0.004 MI:hsa-miR-449b mi 1 MI:hsa-miR-449b 1 Q8IWF2,Q495W5 477 2.70e-02 505 6 2 0.333 0.004 MI:hsa-miR-214 mi 1 MI:hsa-miR-214 1 Q24JP5,Q9NYU1 477 2.81e-02 516 6 2 0.333 0.004 MI:mmu-miR-673-5p mi 1 MI:mmu-miR-673-5p 1 Q24JP5,Q9NYU1 477 2.96e-02 531 6 2 0.333 0.004 MI:hsa-miR-34c-5p mi 1 MI:hsa-miR-34c-5p 1 Q9NYU1,Q495W5 477 3.35e-02 138 6 2 0.333 0.014 GO:0016758 MF 1 transferase activity, transferring hexosyl groups 1 Q9NYU1,Q495W5 477 3.38e-02 4 6 1 0.167 0.250 GO:0060972 BP 1 left/right pattern formation 1 Q7Z7M0 477 3.38e-02 4 6 1 0.167 0.250 GO:0097094 BP 1 craniofacial suture morphogenesis 1 Q7Z7M0 477 3.52e-02 572 6 3 0.500 0.005 GO:0044712 BP 1 single-organism catabolic process 1 Q8IWF2,Q9NYU1,P39060 477 3.63e-02 592 6 2 0.333 0.003 MI:hsa-miR-518a-3p mi 1 MI:hsa-miR-518a-3p 1 Q8IWF2,Q7Z7M0 477 4.14e-02 19 6 1 0.167 0.053 REAC:901032 rea 1 ER Quality Control Compartment (ERQC) 1 Q9NYU1 477 4.22e-02 5 6 1 0.167 0.200 GO:1902669 BP 1 positive regulation of axon guidance 1 Q7Z7M0 477 4.22e-02 5 6 1 0.167 0.200 GO:0048842 BP 1 positive regulation of axon extension involved in axon guidance 1 Q7Z7M0 477 5.00e-02 23 6 1 0.167 0.043 REAC:3000157 rea 1 Laminin interactions 1 P39060 477 5.00e-02 2 6 1 0.167 0.500 HP:0009613 hp 1 Duplication of the proximal phalanx of the thumb 1 Q7Z7M0 477 5.00e-02 169 6 2 0.333 0.012 GO:0006486 BP 1 protein glycosylation 1 Q9NYU1,Q495W5 477 5.00e-02 2 6 1 0.167 0.500 HP:0006397 hp 1 Lateral displacement of patellae 1 Q7Z7M0 477 5.00e-02 3 6 1 0.167 0.333 CORUM:2853 cor 1 ITGA5-ITGB1-CAL4A3 complex 1 P39060 477 5.00e-02 169 6 2 0.333 0.012 GO:0043413 BP 1 macromolecule glycosylation 1 Q9NYU1,Q495W5 477 5.00e-02 2 6 1 0.167 0.500 HP:0010008 hp 1 Duplication of the middle phalanx of hand 1 Q7Z7M0 477 5.00e-02 2 6 1 0.167 0.500 HP:0009608 hp 1 Complete duplication of proximal phalanx of the thumb 1 Q7Z7M0 477 5.00e-02 2 6 1 0.167 0.500 HP:0010093 hp 1 Duplication of the proximal phalanx of the hallux 1 Q7Z7M0 477 5.00e-02 2 6 1 0.167 0.500 HP:0011493 hp 1 Central opacification of the cornea 1 P39060 477 5.00e-02 2 6 1 0.167 0.500 HP:0000585 hp 1 Band keratopathy 1 P39060 477 5.00e-02 1 6 1 0.167 1.000 OMIM:614976 omi 1 CARPENTER SYNDROME 2; CRPT2 1 Q7Z7M0 477 5.00e-02 2 6 1 0.167 0.500 HP:0010002 hp 1 Complete duplication of the middle phalanges of the hand 1 Q7Z7M0 477 5.00e-02 1 6 1 0.167 1.000 OMIM:267750 omi 1 KNOBLOCH SYNDROME 1; KNO1;;KNO;;RETINAL DETACHMENT AND OCCIPITAL ENCEPHALOCELE 1 P39060 477 5.00e-02 2 6 1 0.167 0.500 HP:0010275 hp 1 Pseudoepiphyses of the proximal phalanges of the hand 1 Q7Z7M0 477 5.00e-02 2 6 1 0.167 0.500 HP:0010202 hp 1 Duplication of middle phalanx of toe 1 Q7Z7M0 477 5.00e-02 1395 6 5 0.833 0.004 TF:M05467_1 tf 1 Factor: Sall1; motif: NGGTCCKRGKRA; match class: 1 1 Q24JP5,Q9NYU1,Q7Z7M0,P39060,Q495W5 478 1.07e-02 940 2 2 1.000 0.002 TF:M06080_0 tf 1 Factor: ZNF99; motif: KGGKGTGAGA; match class: 0 1 Q13451,Q96Q40 478 1.51e-02 49 2 1 0.500 0.020 TF:M03789_1 tf 1 Factor: ChREBP; motif: CACGTGMCHNCB; match class: 1 1 Q13451 478 1.51e-02 49 2 1 0.500 0.020 TF:M05632_0 tf 1 Factor: ZNF286B; motif: NGYTTWGAAARA; match class: 0 1 Q96Q40 478 1.83e-02 1462 2 2 1.000 0.001 HPA:030010_03 hpa 1 prostate; glandular cells[Uncertain,High] 1 Q13451,Q96Q40 478 2.13e-02 69 2 1 0.500 0.014 TF:M06014_0 tf 1 Factor: ZNF643; motif: KGGKACTAGATG; match class: 0 1 Q96Q40 478 2.22e-02 72 2 1 0.500 0.014 TF:M00481_1 tf 1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 1 Q13451 478 2.34e-02 76 2 1 0.500 0.013 TF:M06461_0 tf 1 Factor: ZNF557; motif: NMAGGCTGMCGC; match class: 0 1 Q13451 478 2.35e-02 16 2 1 0.500 0.062 GO:0005527 MF 1 macrolide binding 1 Q13451 478 2.35e-02 16 2 1 0.500 0.062 GO:0005528 MF 1 FK506 binding 1 Q13451 478 2.40e-02 78 2 1 0.500 0.013 TF:M01261_1 tf 1 Factor: HNF3A; motif: RWGTAAACAN; match class: 1 1 Q96Q40 478 2.62e-02 85 2 1 0.500 0.012 TF:M00236_0 tf 1 Factor: Arnt; motif: NDDNNCACGTGNNNNN; match class: 0 1 Q13451 478 2.94e-02 160 2 1 0.500 0.006 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 Q13451 478 3.13e-02 5 2 1 0.500 0.200 CORUM:5285 cor 1 TNF-alpha/NF-kappa B signaling complex 9 1 Q13451 478 3.13e-02 5 2 1 0.500 0.200 CORUM:5269 cor 1 TNF-alpha/NF-kappa B signaling complex 8 1 Q13451 478 3.26e-02 106 2 1 0.500 0.009 TF:M02104_1 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 1 1 Q13451 478 3.38e-02 1985 2 2 1.000 0.001 HPA:039010_02 hpa 1 soft tissue 1; adipocytes[Uncertain,Medium] 1 Q13451,Q96Q40 478 3.48e-02 2013 2 2 1.000 0.001 HPA:018010_02 hpa 1 hippocampus; glial cells[Uncertain,Medium] 1 Q13451,Q96Q40 478 3.61e-02 2051 2 2 1.000 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q13451,Q96Q40 478 3.67e-02 200 2 1 0.500 0.005 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 Q13451 478 3.69e-02 201 2 1 0.500 0.005 HPA:012010_13 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,High] 1 Q13451 478 3.78e-02 123 2 1 0.500 0.008 TF:M06092_0 tf 1 Factor: ZNF28; motif: NGGGAATWCCRW; match class: 0 1 Q96Q40 478 3.84e-02 1778 2 2 1.000 0.001 TF:M01821_1 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 1 1 Q13451,Q96Q40 478 4.02e-02 2165 2 2 1.000 0.001 HPA:026020_02 hpa 1 ovary; ovarian stroma cells[Uncertain,Medium] 1 Q13451,Q96Q40 478 4.15e-02 135 2 1 0.500 0.007 TF:M01224_1 tf 1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 1 Q13451 478 4.23e-02 1868 2 2 1.000 0.001 TF:M01996_1 tf 1 Factor: AR; motif: GNNCNNNNTGTTCTN; match class: 1 1 Q13451,Q96Q40 478 4.27e-02 233 2 1 0.500 0.004 HPA:038010_13 hpa 1 smooth muscle; smooth muscle cells[Supportive,High] 1 Q13451 478 4.61e-02 150 2 1 0.500 0.007 TF:M00292_1 tf 1 Factor: Freac-4; motif: CTWAWGTAAACANWGN; match class: 1 1 Q96Q40 478 4.67e-02 152 2 1 0.500 0.007 TF:M04166_0 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 0 1 Q13451 478 4.67e-02 152 2 1 0.500 0.007 TF:M04158_0 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 0 1 Q13451 478 4.67e-02 152 2 1 0.500 0.007 TF:M04166_1 tf 1 Factor: BHLHE41; motif: RTCACGTGAC; match class: 1 1 Q13451 478 4.67e-02 152 2 1 0.500 0.007 TF:M04158_1 tf 1 Factor: ARNTL; motif: GTCACGTGAC; match class: 1 1 Q13451 478 4.80e-02 272 2 1 0.500 0.004 MI:hsa-miR-744* mi 1 MI:hsa-miR-744* 1 Q96Q40 478 4.88e-02 159 2 1 0.500 0.006 TF:M01248_1 tf 1 Factor: DAX1; motif: NNRNNNNAAGGTCANNNNNN; match class: 1 1 Q96Q40 478 4.91e-02 2392 2 2 1.000 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q13451,Q96Q40 478 4.91e-02 160 2 1 0.500 0.006 TF:M06001_0 tf 1 Factor: ZNF316; motif: RTTGAAAAGM; match class: 0 1 Q13451 478 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q13451 478 5.00e-02 8 2 1 0.500 0.125 CORUM:5268 cor 1 TNF-alpha/NF-kappa B signaling complex 7 1 Q13451 478 5.00e-02 34 2 1 0.500 0.029 GO:0003755 MF 1 peptidyl-prolyl cis-trans isomerase activity 1 Q13451 478 5.00e-02 2030 2 2 1.000 0.001 TF:M03869_0 tf 1 Factor: Fra-1; motif: TGACTCAN; match class: 0 1 Q13451,Q96Q40 478 5.00e-02 2030 2 2 1.000 0.001 TF:M03552_0 tf 1 Factor: JunD; motif: TGACTCAN; match class: 0 1 Q13451,Q96Q40 478 5.00e-02 2030 2 2 1.000 0.001 TF:M03538_0 tf 1 Factor: AP-1; motif: TGACTCAN; match class: 0 1 Q13451,Q96Q40 478 5.00e-02 80 2 1 0.500 0.013 KEGG:04915 keg 1 Estrogen signaling pathway 1 Q13451 478 5.00e-02 2 2 1 0.500 0.500 OMIM:608516 omi 1 MAJOR DEPRESSIVE DISORDER; MDD;;UNIPOLAR DEPRESSIONSEASONAL AFFECTIVE DISORDER, INCLUDED; SAD, INCLUDED 1 Q13451 479 3.82e-09 102 7 5 0.714 0.049 GO:0007163 BP 1 establishment or maintenance of cell polarity 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0 479 1.05e-07 63 7 4 0.571 0.063 GO:0030010 BP 1 establishment of cell polarity 1 Q05513,Q8IX03,Q15334,Q8TEW0 479 8.92e-07 128 7 5 0.714 0.039 KEGG:04390 keg 1 Hippo signaling pathway 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0 479 3.37e-05 111 7 4 0.571 0.036 KEGG:04530 keg 1 Tight junction 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 1.15e-04 11 7 2 0.286 0.182 REAC:420029 rea 1 Tight junction interactions 1 Q9BYG5,Q8TEW0 479 1.96e-04 3 7 2 0.286 0.667 CORUM:959 cor 1 LLGL1-PAR-6B-PRKCI complex 1 Q9BYG5,Q15334 479 1.96e-04 3 7 2 0.286 0.667 CORUM:956 cor 1 PAR-3-PAR-6B-PRKCI complex 1 Q9BYG5,Q8TEW0 479 2.18e-04 15 7 2 0.286 0.133 REAC:2173791 rea 1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 1 Q05513,Q8TEW0 479 5.13e-04 30 7 2 0.286 0.067 GO:0070830 BP 1 bicellular tight junction assembly 1 Q9BYG5,Q8TEW0 479 5.96e-04 195 7 3 0.429 0.015 GO:0007409 BP 1 axonogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 7.22e-04 208 7 3 0.429 0.014 GO:0061564 BP 1 axon development 1 Q9BYG5,Q15334,Q8TEW0 479 7.82e-04 28 7 2 0.286 0.071 REAC:421270 rea 1 Cell-cell junction organization 1 Q9BYG5,Q8TEW0 479 7.84e-04 37 7 2 0.286 0.054 GO:0043297 BP 1 apical junction assembly 1 Q9BYG5,Q8TEW0 479 9.17e-04 40 7 2 0.286 0.050 GO:0005923 CC 1 bicellular tight junction 1 Q9BYG5,Q8TEW0 479 9.64e-04 41 7 2 0.286 0.049 GO:0070160 CC 1 occluding junction 1 Q9BYG5,Q8TEW0 479 1.12e-03 241 7 3 0.429 0.012 GO:0048667 BP 1 cell morphogenesis involved in neuron differentiation 1 Q9BYG5,Q15334,Q8TEW0 479 1.36e-03 1340 7 5 0.714 0.004 GO:0032879 BP 1 regulation of localization 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q15678 479 1.61e-03 53 7 2 0.286 0.038 GO:0043296 CC 1 apical junction complex 1 Q9BYG5,Q8TEW0 479 1.70e-03 278 7 3 0.429 0.011 GO:0048812 BP 1 neuron projection morphogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 1.74e-03 55 7 2 0.286 0.036 GO:0007043 BP 1 cell-cell junction assembly 1 Q9BYG5,Q8TEW0 479 1.94e-03 291 7 3 0.429 0.010 GO:0048858 BP 1 cell projection morphogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 2.07e-03 60 7 2 0.286 0.033 GO:0004725 MF 1 protein tyrosine phosphatase activity 1 Q16825,Q15678 479 2.10e-03 299 7 3 0.429 0.010 GO:0032990 BP 1 cell part morphogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 2.14e-03 2485 7 6 0.857 0.002 GO:0044767 BP 1 single-organism developmental process 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 2.29e-03 1 7 1 0.143 1.000 GO:2000664 BP 1 positive regulation of interleukin-5 secretion 1 Q05513 479 2.43e-03 314 7 3 0.429 0.010 GO:0000904 BP 1 cell morphogenesis involved in differentiation 1 Q9BYG5,Q15334,Q8TEW0 479 2.53e-03 3017 7 6 0.857 0.002 HPA:007040_02 hpa 1 cerebral cortex; neuropil[Uncertain,Medium] 1 Q05513,Q16825,Q8IX03,Q15334,Q8TEW0,Q15678 479 2.66e-03 2580 7 6 0.857 0.002 GO:0032502 BP 1 developmental process 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 2.71e-03 52 7 2 0.286 0.038 REAC:446728 rea 1 Cell junction organization 1 Q9BYG5,Q8TEW0 479 3.11e-03 842 7 4 0.571 0.005 GO:0070271 BP 1 protein complex biogenesis 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 3.11e-03 842 7 4 0.571 0.005 GO:0006461 BP 1 protein complex assembly 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 3.50e-03 2706 7 6 0.857 0.002 GO:0044707 BP 1 single-multicellular organism process 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 3.70e-03 149 7 3 0.429 0.020 KEGG:04360 keg 1 Axon guidance 1 Q05513,Q9BYG5,Q8TEW0 479 4.16e-03 155 7 3 0.429 0.019 KEGG:04015 keg 1 Rap1 signaling pathway 1 Q05513,Q9BYG5,Q8TEW0 479 4.43e-03 386 7 3 0.429 0.008 GO:0019900 MF 1 kinase binding 1 Q8IX03,Q15334,Q15678 479 4.49e-03 67 7 2 0.286 0.030 REAC:170834 rea 1 Signaling by TGF-beta Receptor Complex 1 Q05513,Q8TEW0 479 4.57e-03 2 7 1 0.143 0.500 GO:2000662 BP 1 regulation of interleukin-5 secretion 1 Q05513 479 4.57e-03 2 7 1 0.143 0.500 GO:0072603 BP 1 interleukin-5 secretion 1 Q05513 479 4.57e-03 2 7 1 0.143 0.500 GO:0046628 BP 1 positive regulation of insulin receptor signaling pathway 1 Q05513 479 4.65e-03 936 7 4 0.571 0.004 GO:0051049 BP 1 regulation of transport 1 Q05513,Q8IX03,Q15334,Q15678 479 4.92e-03 400 7 3 0.429 0.007 GO:0031175 BP 1 neuron projection development 1 Q9BYG5,Q15334,Q8TEW0 479 5.17e-03 407 7 3 0.429 0.007 GO:0051223 BP 1 regulation of protein transport 1 Q05513,Q15334,Q15678 479 5.20e-03 964 7 4 0.571 0.004 GO:0015031 BP 1 protein transport 1 Q05513,Q15334,Q8TEW0,Q15678 479 5.66e-03 420 7 3 0.429 0.007 GO:0005911 CC 1 cell-cell junction 1 Q05513,Q9BYG5,Q8TEW0 479 5.66e-03 1810 7 5 0.714 0.003 GO:0048731 BP 1 system development 1 Q05513,Q9BYG5,Q15334,Q8TEW0,Q15678 479 6.29e-03 1851 7 5 0.714 0.003 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 Q05513,Q16825,Q8IX03,Q8TEW0,Q15678 479 6.32e-03 1015 7 4 0.571 0.004 GO:0071822 BP 1 protein complex subunit organization 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 6.61e-03 443 7 3 0.429 0.007 GO:0048666 BP 1 neuron development 1 Q9BYG5,Q15334,Q8TEW0 479 6.66e-03 108 7 2 0.286 0.019 GO:0007179 BP 1 transforming growth factor beta receptor signaling pathway 1 Q05513,Q8TEW0 479 6.85e-03 3 7 1 0.143 0.333 GO:0033269 CC 1 internode region of axon 1 Q8TEW0 479 6.85e-03 3 7 1 0.143 0.333 GO:0032754 BP 1 positive regulation of interleukin-5 production 1 Q05513 479 6.85e-03 3 7 1 0.143 0.333 GO:2000667 BP 1 positive regulation of interleukin-13 secretion 1 Q05513 479 6.91e-03 110 7 2 0.286 0.018 GO:0030424 CC 1 axon 1 Q15334,Q8TEW0 479 7.25e-03 3073 7 6 0.857 0.002 GO:0032501 BP 1 multicellular organismal process 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 7.53e-03 1923 7 5 0.714 0.003 GO:0006793 BP 1 phosphorus metabolic process 1 Q05513,Q16825,Q8IX03,Q8TEW0,Q15678 479 7.69e-03 467 7 3 0.429 0.006 GO:0070201 BP 1 regulation of establishment of protein localization 1 Q05513,Q15334,Q15678 479 8.08e-03 475 7 3 0.429 0.006 GO:0000902 BP 1 cell morphogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 8.56e-03 1100 7 4 0.571 0.004 GO:0045184 BP 1 establishment of protein localization 1 Q05513,Q15334,Q8TEW0,Q15678 479 8.61e-03 123 7 2 0.286 0.016 GO:0004721 MF 1 phosphoprotein phosphatase activity 1 Q16825,Q15678 479 8.77e-03 94 7 2 0.286 0.021 REAC:1500931 rea 1 Cell-Cell communication 1 Q9BYG5,Q8TEW0 479 8.77e-03 1107 7 4 0.571 0.004 GO:0009653 BP 1 anatomical structure morphogenesis 1 Q9BYG5,Q15334,Q8TEW0,Q15678 479 8.95e-03 1113 7 4 0.571 0.004 GO:0065003 BP 1 macromolecular complex assembly 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 9.13e-03 4 7 1 0.143 0.250 GO:2000665 BP 1 regulation of interleukin-13 secretion 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:2001181 BP 1 positive regulation of interleukin-10 secretion 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:2000553 BP 1 positive regulation of T-helper 2 cell cytokine production 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:0032736 BP 1 positive regulation of interleukin-13 production 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:0045630 BP 1 positive regulation of T-helper 2 cell differentiation 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:0072611 BP 1 interleukin-13 secretion 1 Q05513 479 9.13e-03 4 7 1 0.143 0.250 GO:0000137 CC 1 Golgi cis cisterna 1 Q15334 479 9.17e-03 127 7 2 0.286 0.016 GO:0034329 BP 1 cell junction assembly 1 Q9BYG5,Q8TEW0 479 9.19e-03 2007 7 5 0.714 0.002 GO:0007275 BP 1 multicellular organism development 1 Q05513,Q9BYG5,Q15334,Q8TEW0,Q15678 479 9.32e-03 128 7 2 0.286 0.016 GO:0071560 BP 1 cellular response to transforming growth factor beta stimulus 1 Q05513,Q8TEW0 479 9.46e-03 129 7 2 0.286 0.016 GO:0071559 BP 1 response to transforming growth factor beta 1 Q05513,Q8TEW0 479 9.90e-03 132 7 2 0.286 0.015 GO:0045216 BP 1 cell-cell junction organization 1 Q9BYG5,Q8TEW0 479 1.02e-02 515 7 3 0.429 0.006 GO:0032989 BP 1 cellular component morphogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 1.08e-02 138 7 2 0.286 0.014 GO:0006470 BP 1 protein dephosphorylation 1 Q16825,Q15678 479 1.14e-02 5 7 1 0.143 0.200 GO:2000551 BP 1 regulation of T-helper 2 cell cytokine production 1 Q05513 479 1.14e-02 5 7 1 0.143 0.200 GO:2001179 BP 1 regulation of interleukin-10 secretion 1 Q05513 479 1.14e-02 5 7 1 0.143 0.200 GO:0032753 BP 1 positive regulation of interleukin-4 production 1 Q05513 479 1.14e-02 5 7 1 0.143 0.200 GO:0031643 BP 1 positive regulation of myelination 1 Q8TEW0 479 1.14e-02 5 7 1 0.143 0.200 GO:0045064 BP 1 T-helper 2 cell differentiation 1 Q05513 479 1.14e-02 5 7 1 0.143 0.200 GO:0045628 BP 1 regulation of T-helper 2 cell differentiation 1 Q05513 479 1.15e-02 537 7 3 0.429 0.006 GO:0030182 BP 1 neuron differentiation 1 Q9BYG5,Q15334,Q8TEW0 479 1.19e-02 544 7 3 0.429 0.006 GO:0032880 BP 1 regulation of protein localization 1 Q05513,Q15334,Q15678 479 1.26e-02 5782 7 7 1.000 0.001 HPA:007040_01 hpa 1 cerebral cortex; neuropil[Uncertain,Low] 1 Q05513,Q16825,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 1.29e-02 229 7 3 0.429 0.013 KEGG:04144 keg 1 Endocytosis 1 Q05513,Q9BYG5,Q8TEW0 479 1.29e-02 3401 7 6 0.857 0.002 GO:0051179 BP 1 localization 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 1.37e-02 6 7 1 0.143 0.167 GO:0032656 BP 1 regulation of interleukin-13 production 1 Q05513 479 1.37e-02 6 7 1 0.143 0.167 GO:0043560 MF 1 insulin receptor substrate binding 1 Q05513 479 1.37e-02 6 7 1 0.143 0.167 GO:0035745 BP 1 T-helper 2 cell cytokine production 1 Q05513 479 1.37e-02 6 7 1 0.143 0.167 GO:0035331 BP 1 negative regulation of hippo signaling 1 Q8IX03 479 1.37e-02 6 7 1 0.143 0.167 GO:0031646 BP 1 positive regulation of neurological system process 1 Q8TEW0 479 1.37e-02 6 7 1 0.143 0.167 GO:0032674 BP 1 regulation of interleukin-5 production 1 Q05513 479 1.37e-02 6 7 1 0.143 0.167 GO:0072608 BP 1 interleukin-10 secretion 1 Q05513 479 1.37e-02 6 7 1 0.143 0.167 GO:0032634 BP 1 interleukin-5 production 1 Q05513 479 1.37e-02 156 7 2 0.286 0.013 GO:0034330 BP 1 cell junction organization 1 Q9BYG5,Q8TEW0 479 1.47e-02 586 7 3 0.429 0.005 GO:0048699 BP 1 generation of neurons 1 Q9BYG5,Q15334,Q8TEW0 479 1.60e-02 7 7 1 0.143 0.143 GO:0022011 BP 1 myelination in peripheral nervous system 1 Q8TEW0 479 1.60e-02 7 7 1 0.143 0.143 GO:1900078 BP 1 positive regulation of cellular response to insulin stimulus 1 Q05513 479 1.60e-02 7 7 1 0.143 0.143 GO:0032292 BP 1 peripheral nervous system axon ensheathment 1 Q8TEW0 479 1.60e-02 7 7 1 0.143 0.143 GO:0014044 BP 1 Schwann cell development 1 Q8TEW0 479 1.60e-02 7 7 1 0.143 0.143 GO:0035743 BP 1 CD4-positive, alpha-beta T cell cytokine production 1 Q05513 479 1.60e-02 7 7 1 0.143 0.143 GO:0032616 BP 1 interleukin-13 production 1 Q05513 479 1.60e-02 7 7 1 0.143 0.143 GO:0002830 BP 1 positive regulation of type 2 immune response 1 Q05513 479 1.63e-02 170 7 2 0.286 0.012 GO:0050708 BP 1 regulation of protein secretion 1 Q05513,Q15334 479 1.64e-02 2275 7 5 0.714 0.002 GO:0036211 BP 1 protein modification process 1 Q05513,Q16825,Q8IX03,Q8TEW0,Q15678 479 1.64e-02 2275 7 5 0.714 0.002 GO:0006464 BP 1 cellular protein modification process 1 Q05513,Q16825,Q8IX03,Q8TEW0,Q15678 479 1.70e-02 174 7 2 0.286 0.011 GO:0007178 BP 1 transmembrane receptor protein serine/threonine kinase signaling pathway 1 Q05513,Q8TEW0 479 1.71e-02 618 7 3 0.429 0.005 GO:0022008 BP 1 neurogenesis 1 Q9BYG5,Q15334,Q8TEW0 479 1.74e-02 6052 7 7 1.000 0.001 HPA:009030_01 hpa 1 colon; peripheral nerve/ganglion[Uncertain,Low] 1 Q05513,Q16825,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 1.82e-02 8 7 1 0.143 0.125 GO:0032673 BP 1 regulation of interleukin-4 production 1 Q05513 479 1.82e-02 8 7 1 0.143 0.125 GO:0032633 BP 1 interleukin-4 production 1 Q05513 479 1.82e-02 8 7 1 0.143 0.125 GO:0001946 BP 1 lymphangiogenesis 1 Q15678 479 1.82e-02 8 7 1 0.143 0.125 GO:0035330 BP 1 regulation of hippo signaling 1 Q8IX03 479 1.82e-02 8 7 1 0.143 0.125 GO:0045624 BP 1 positive regulation of T-helper cell differentiation 1 Q05513 479 1.92e-02 2353 7 5 0.714 0.002 GO:0048856 BP 1 anatomical structure development 1 Q05513,Q9BYG5,Q15334,Q8TEW0,Q15678 479 1.98e-02 1377 7 4 0.571 0.003 GO:0071702 BP 1 organic substance transport 1 Q05513,Q15334,Q8TEW0,Q15678 479 1.98e-02 650 7 3 0.429 0.005 GO:0030030 BP 1 cell projection organization 1 Q9BYG5,Q15334,Q8TEW0 479 2.05e-02 9 7 1 0.143 0.111 GO:0036303 BP 1 lymph vessel morphogenesis 1 Q15678 479 2.05e-02 9 7 1 0.143 0.111 GO:0010801 BP 1 negative regulation of peptidyl-threonine phosphorylation 1 Q8TEW0 479 2.05e-02 9 7 1 0.143 0.111 GO:0002828 BP 1 regulation of type 2 immune response 1 Q05513 479 2.05e-02 9 7 1 0.143 0.111 GO:0004697 MF 1 protein kinase C activity 1 Q05513 479 2.05e-02 9 7 1 0.143 0.111 GO:0046621 BP 1 negative regulation of organ growth 1 Q8IX03 479 2.06e-02 1393 7 4 0.571 0.003 GO:0008104 BP 1 protein localization 1 Q05513,Q15334,Q8TEW0,Q15678 479 2.17e-02 2417 7 5 0.714 0.002 GO:0043412 BP 1 macromolecule modification 1 Q05513,Q16825,Q8IX03,Q8TEW0,Q15678 479 2.19e-02 2420 7 5 0.714 0.002 GO:0005886 CC 1 plasma membrane 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0 479 2.26e-02 201 7 2 0.286 0.010 GO:0016791 MF 1 phosphatase activity 1 Q16825,Q15678 479 2.28e-02 10 7 1 0.143 0.100 GO:0008356 BP 1 asymmetric cell division 1 Q8TEW0 479 2.28e-02 10 7 1 0.143 0.100 GO:0032733 BP 1 positive regulation of interleukin-10 production 1 Q05513 479 2.28e-02 10 7 1 0.143 0.100 GO:0045622 BP 1 regulation of T-helper cell differentiation 1 Q05513 479 2.28e-02 10 7 1 0.143 0.100 GO:0031641 BP 1 regulation of myelination 1 Q8TEW0 479 2.28e-02 10 7 1 0.143 0.100 GO:0043372 BP 1 positive regulation of CD4-positive, alpha-beta T cell differentiation 1 Q05513 479 2.28e-02 10 7 1 0.143 0.100 GO:0002726 BP 1 positive regulation of T cell cytokine production 1 Q05513 479 2.40e-02 2469 7 5 0.714 0.002 GO:0071944 CC 1 cell periphery 1 Q05513,Q8IX03,Q9BYG5,Q15334,Q8TEW0 479 2.43e-02 209 7 2 0.286 0.010 GO:0009306 BP 1 protein secretion 1 Q05513,Q15334 479 2.44e-02 700 7 3 0.429 0.004 GO:0001932 BP 1 regulation of protein phosphorylation 1 Q05513,Q8IX03,Q8TEW0 479 2.51e-02 11 7 1 0.143 0.091 GO:0014037 BP 1 Schwann cell differentiation 1 Q8TEW0 479 2.51e-02 11 7 1 0.143 0.091 GO:0042092 BP 1 type 2 immune response 1 Q05513 479 2.51e-02 11 7 1 0.143 0.091 GO:0060291 BP 1 long-term synaptic potentiation 1 Q05513 479 2.66e-02 1493 7 4 0.571 0.003 GO:0051649 BP 1 establishment of localization in cell 1 Q8IX03,Q15334,Q8TEW0,Q15678 479 2.66e-02 219 7 2 0.286 0.009 GO:0016311 BP 1 dephosphorylation 1 Q16825,Q15678 479 2.72e-02 728 7 3 0.429 0.004 GO:0042995 CC 1 cell projection 1 Q8IX03,Q15334,Q8TEW0 479 2.73e-02 12 7 1 0.143 0.083 GO:0002724 BP 1 regulation of T cell cytokine production 1 Q05513 479 2.73e-02 12 7 1 0.143 0.083 GO:2000516 BP 1 positive regulation of CD4-positive, alpha-beta T cell activation 1 Q05513 479 2.73e-02 12 7 1 0.143 0.083 GO:0090162 BP 1 establishment of epithelial cell polarity 1 Q8TEW0 479 2.73e-02 12 7 1 0.143 0.083 GO:0001945 BP 1 lymph vessel development 1 Q15678 479 2.73e-02 12 7 1 0.143 0.083 GO:0007205 BP 1 protein kinase C-activating G-protein coupled receptor signaling pathway 1 Q8TEW0 479 2.74e-02 222 7 2 0.286 0.009 GO:0001933 BP 1 negative regulation of protein phosphorylation 1 Q05513,Q8TEW0 479 2.79e-02 6474 7 7 1.000 0.001 HPA:027020_01 hpa 1 pancreas; islets of Langerhans[Uncertain,Low] 1 Q05513,Q16825,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 2.87e-02 1524 7 4 0.571 0.003 GO:0030154 BP 1 cell differentiation 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 2.92e-02 746 7 3 0.429 0.004 GO:0030054 CC 1 cell junction 1 Q05513,Q9BYG5,Q8TEW0 479 2.96e-02 13 7 1 0.143 0.077 GO:0031644 BP 1 regulation of neurological system process 1 Q8TEW0 479 2.96e-02 13 7 1 0.143 0.077 GO:0043370 BP 1 regulation of CD4-positive, alpha-beta T cell differentiation 1 Q05513 479 3.03e-02 234 7 2 0.286 0.009 GO:0043410 BP 1 positive regulation of MAPK cascade 1 Q05513,Q8IX03 479 3.07e-02 760 7 3 0.429 0.004 GO:0042325 BP 1 regulation of phosphorylation 1 Q05513,Q8IX03,Q8TEW0 479 3.19e-02 14 7 1 0.143 0.071 GO:0032653 BP 1 regulation of interleukin-10 production 1 Q05513 479 3.19e-02 14 7 1 0.143 0.071 GO:0002369 BP 1 T cell cytokine production 1 Q05513 479 3.19e-02 14 7 1 0.143 0.071 GO:2000463 BP 1 positive regulation of excitatory postsynaptic potential 1 Q05513 479 3.19e-02 14 7 1 0.143 0.071 GO:0046638 BP 1 positive regulation of alpha-beta T cell differentiation 1 Q05513 479 3.27e-02 2644 7 5 0.714 0.002 GO:0006810 BP 1 transport 1 Q05513,Q8IX03,Q15334,Q8TEW0,Q15678 479 3.34e-02 246 7 2 0.286 0.008 GO:0042326 BP 1 negative regulation of phosphorylation 1 Q05513,Q8TEW0 479 3.42e-02 15 7 1 0.143 0.067 GO:0002720 BP 1 positive regulation of cytokine production involved in immune response 1 Q05513 479 3.42e-02 790 7 3 0.429 0.004 GO:0048468 BP 1 cell development 1 Q9BYG5,Q15334,Q8TEW0 479 3.54e-02 1614 7 4 0.571 0.002 GO:0043933 BP 1 macromolecular complex subunit organization 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 3.57e-02 1618 7 4 0.571 0.002 GO:0033036 BP 1 macromolecule localization 1 Q05513,Q15334,Q8TEW0,Q15678 479 3.64e-02 16 7 1 0.143 0.062 GO:0098815 BP 1 modulation of excitatory postsynaptic potential 1 Q05513 479 3.64e-02 16 7 1 0.143 0.062 GO:0032613 BP 1 interleukin-10 production 1 Q05513 479 3.64e-02 16 7 1 0.143 0.062 GO:2000514 BP 1 regulation of CD4-positive, alpha-beta T cell activation 1 Q05513 479 3.64e-02 16 7 1 0.143 0.062 GO:0032878 BP 1 regulation of establishment or maintenance of cell polarity 1 Q15334 479 3.71e-02 260 7 2 0.286 0.008 GO:0042578 MF 1 phosphoric ester hydrolase activity 1 Q16825,Q15678 479 3.81e-02 435 7 3 0.429 0.007 MI:hsa-miR-193a-3p mi 1 MI:hsa-miR-193a-3p 1 Q05513,Q16825,Q15334 479 3.82e-02 1649 7 4 0.571 0.002 GO:0048869 BP 1 cellular developmental process 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 3.87e-02 17 7 1 0.143 0.059 GO:0031985 CC 1 Golgi cisterna 1 Q15334 479 3.87e-02 17 7 1 0.143 0.059 GO:0030866 BP 1 cortical actin cytoskeleton organization 1 Q15334 479 3.90e-02 2748 7 5 0.714 0.002 GO:0051234 BP 1 establishment of localization 1 Q05513,Q8IX03,Q15334,Q8TEW0,Q15678 479 3.99e-02 270 7 2 0.286 0.007 GO:1903530 BP 1 regulation of secretion by cell 1 Q05513,Q15334 479 4.10e-02 18 7 1 0.143 0.056 GO:0046637 BP 1 regulation of alpha-beta T cell differentiation 1 Q05513 479 4.10e-02 18 7 1 0.143 0.056 GO:0002711 BP 1 positive regulation of T cell mediated immunity 1 Q05513 479 4.10e-02 18 7 1 0.143 0.056 GO:0021782 BP 1 glial cell development 1 Q8TEW0 479 4.10e-02 18 7 1 0.143 0.056 GO:0051294 BP 1 establishment of spindle orientation 1 Q15334 479 4.26e-02 452 7 3 0.429 0.007 MI:hsa-miR-576-3p mi 1 MI:hsa-miR-576-3p 1 Q05513,Q16825,Q15678 479 4.32e-02 1706 7 4 0.571 0.002 GO:0022607 BP 1 cellular component assembly 1 Q05513,Q9BYG5,Q15334,Q8TEW0 479 4.43e-02 285 7 2 0.286 0.007 GO:0051046 BP 1 regulation of secretion 1 Q05513,Q15334 479 4.46e-02 286 7 2 0.286 0.007 GO:0043005 CC 1 neuron projection 1 Q15334,Q8TEW0 479 4.55e-02 20 7 1 0.143 0.050 GO:0060079 BP 1 excitatory postsynaptic potential 1 Q05513 479 4.55e-02 20 7 1 0.143 0.050 GO:0046635 BP 1 positive regulation of alpha-beta T cell activation 1 Q05513 479 4.55e-02 20 7 1 0.143 0.050 GO:0046825 BP 1 regulation of protein export from nucleus 1 Q15678 479 4.55e-02 20 7 1 0.143 0.050 GO:1900077 BP 1 negative regulation of cellular response to insulin stimulus 1 Q05513 479 4.55e-02 20 7 1 0.143 0.050 GO:0042093 BP 1 T-helper cell differentiation 1 Q05513 479 4.55e-02 20 7 1 0.143 0.050 GO:0046627 BP 1 negative regulation of insulin receptor signaling pathway 1 Q05513 479 4.69e-02 885 7 3 0.429 0.003 GO:0019220 BP 1 regulation of phosphate metabolic process 1 Q05513,Q8IX03,Q8TEW0 479 4.77e-02 21 7 1 0.143 0.048 GO:0030865 BP 1 cortical cytoskeleton organization 1 Q15334 479 4.77e-02 21 7 1 0.143 0.048 GO:0002292 BP 1 T cell differentiation involved in immune response 1 Q05513 479 4.77e-02 21 7 1 0.143 0.048 GO:0002294 BP 1 CD4-positive, alpha-beta T cell differentiation involved in immune response 1 Q05513 479 4.77e-02 21 7 1 0.143 0.048 GO:0002287 BP 1 alpha-beta T cell activation involved in immune response 1 Q05513 479 4.77e-02 21 7 1 0.143 0.048 GO:0002293 BP 1 alpha-beta T cell differentiation involved in immune response 1 Q05513 479 4.87e-02 897 7 3 0.429 0.003 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 Q05513,Q8IX03,Q8TEW0 479 4.94e-02 3675 7 5 0.714 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 Q16825,Q8IX03,Q15334,Q8TEW0,Q15678 479 5.00e-02 478 7 3 0.429 0.006 MI:hsa-miR-486-3p mi 1 MI:hsa-miR-486-3p 1 Q05513,Q16825,Q8TEW0 479 5.00e-02 1 7 1 0.143 1.000 OMIM:615602 omi 1 MEMORY QUANTITATIVE TRAIT LOCUS; MEMRYQTL 1 Q8IX03 479 5.00e-02 2 7 1 0.143 0.500 CORUM:5558 cor 1 PAR6-CDC42 complex 1 Q9BYG5 479 5.00e-02 22 7 1 0.143 0.045 GO:0045582 BP 1 positive regulation of T cell differentiation 1 Q05513 479 5.00e-02 1 7 1 0.143 1.000 OMIM:613611 omi 1 CHOANAL ATRESIA AND LYMPHEDEMA 1 Q15678 479 5.00e-02 120 7 2 0.286 0.017 KEGG:04062 keg 1 Chemokine signaling pathway 1 Q05513,Q8TEW0 479 5.00e-02 7 7 1 0.143 0.143 HP:0001698 hp 1 Pericardial effusion 1 Q15678 479 5.00e-02 2 7 1 0.143 0.500 CORUM:826 cor 1 PAR-3-VE-cadherin-beta-catenin complex 1 Q8TEW0 479 5.00e-02 22 7 1 0.143 0.045 GO:0060078 BP 1 regulation of postsynaptic membrane potential 1 Q05513 479 5.00e-02 3268 7 7 1.000 0.002 TF:M07344_1 tf 1 Factor: ZIC1; motif: VGGGGAGS; match class: 1 1 Q05513,Q16825,Q8IX03,Q9BYG5,Q15334,Q8TEW0,Q15678 479 5.00e-02 20 7 1 0.143 0.050 REAC:2028269 rea 1 Signaling by Hippo 1 Q8IX03 480 4.19e-05 142 4 3 0.750 0.021 GO:0072659 BP 1 protein localization to plasma membrane 1 P49757,Q9H1H9,Q96CW1 480 5.14e-05 152 4 3 0.750 0.020 GO:1990778 BP 1 protein localization to cell periphery 1 P49757,Q9H1H9,Q96CW1 480 5.47e-05 15 4 2 0.500 0.133 GO:1903077 BP 1 negative regulation of protein localization to plasma membrane 1 P49757,Q96CW1 480 6.25e-05 16 4 2 0.500 0.125 GO:1904376 BP 1 negative regulation of protein localization to cell periphery 1 P49757,Q96CW1 480 7.46e-05 172 4 3 0.750 0.017 GO:0007009 BP 1 plasma membrane organization 1 P49757,Q9H1H9,Q96CW1 480 9.89e-05 20 4 2 0.500 0.100 GO:1905476 BP 1 negative regulation of protein localization to membrane 1 P49757,Q96CW1 480 2.71e-04 28 4 2 0.500 0.071 REAC:437239 rea 1 Recycling pathway of L1 1 P49757,Q96CW1 480 5.85e-04 48 4 2 0.500 0.042 GO:1903076 BP 1 regulation of protein localization to plasma membrane 1 P49757,Q96CW1 480 6.10e-04 49 4 2 0.500 0.041 GO:1904375 BP 1 regulation of protein localization to cell periphery 1 P49757,Q96CW1 480 7.15e-04 53 4 2 0.500 0.038 GO:1903729 BP 1 regulation of plasma membrane organization 1 P49757,Q96CW1 480 7.34e-04 369 4 3 0.750 0.008 GO:0072657 BP 1 protein localization to membrane 1 P49757,Q9H1H9,Q96CW1 480 9.61e-04 404 4 3 0.750 0.007 GO:0010256 BP 1 endomembrane system organization 1 P49757,Q9H1H9,Q96CW1 480 1.32e-03 191 4 2 0.500 0.010 TF:M06069_1 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 1 1 Q9H1H9,Q96CW1 480 1.73e-03 1 4 1 0.250 1.000 REAC:164939 rea 1 Nef mediated downregulation of CD28 cell surface expression 1 Q96CW1 480 1.89e-03 86 4 2 0.500 0.023 GO:1903828 BP 1 negative regulation of cellular protein localization 1 P49757,Q96CW1 480 2.04e-03 238 4 2 0.500 0.008 TF:M00082_0 tf 1 Factor: Evi-1; motif: AGATAAGATAN; match class: 0 1 P49757,Q96CW1 480 2.20e-03 7 4 1 0.250 0.143 TF:M05514_0 tf 1 Factor: ZER6; motif: NRTTTGGGCGGR; match class: 0 1 Q96JQ2 480 2.26e-03 94 4 2 0.500 0.021 GO:1905475 BP 1 regulation of protein localization to membrane 1 P49757,Q96CW1 480 2.35e-03 256 4 2 0.500 0.008 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 P49757,Q96CW1 480 2.50e-03 99 4 2 0.500 0.020 GO:0030136 CC 1 clathrin-coated vesicle 1 P49757,Q96CW1 480 3.03e-03 93 4 2 0.500 0.022 REAC:373760 rea 1 L1CAM interactions 1 P49757,Q96CW1 480 3.14e-03 10 4 1 0.250 0.100 TF:M06338_0 tf 1 Factor: ZNF813; motif: NGGTTGGGCAGA; match class: 0 1 Q96CW1 480 3.60e-03 630 4 3 0.750 0.005 GO:0044802 BP 1 single-organism membrane organization 1 P49757,Q9H1H9,Q96CW1 480 3.77e-03 12 4 1 0.250 0.083 TF:M04226_0 tf 1 Factor: TEF; motif: NRTTACRTAANN; match class: 0 1 P49757 480 4.01e-03 2 4 1 0.250 0.500 GO:0021849 BP 1 neuroblast division in subventricular zone 1 P49757 480 5.05e-03 332 4 2 0.500 0.006 MI:hsa-miR-373* mi 1 MI:hsa-miR-373* 1 P49757,Q9H1H9 480 6.01e-03 749 4 3 0.750 0.004 GO:0061024 BP 1 membrane organization 1 P49757,Q9H1H9,Q96CW1 480 6.33e-03 3591 4 4 1.000 0.001 TF:M00425_0 tf 1 Factor: E2F; motif: TTTCGCGC; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 6.52e-03 160 4 2 0.500 0.013 GO:0030135 CC 1 coated vesicle 1 P49757,Q96CW1 480 6.54e-03 771 4 3 0.750 0.004 GO:1902580 BP 1 single-organism cellular localization 1 P49757,Q9H1H9,Q96CW1 480 6.74e-03 1565 4 3 0.750 0.002 TF:M02104_0 tf 1 Factor: NF-E2; motif: CATGACTCAGCANNCN; match class: 0 1 P49757,Q9H1H9,Q96CW1 480 7.01e-03 166 4 2 0.500 0.012 GO:0051301 BP 1 cell division 1 P49757,Q9H1H9 480 7.20e-03 452 4 2 0.500 0.004 TF:M01869_1 tf 1 Factor: C/EBPgamma; motif: NRTKRSRMAAKN; match class: 1 1 P49757,Q96CW1 480 7.31e-03 401 4 2 0.500 0.005 MI:hsa-miR-190b mi 1 MI:hsa-miR-190b 1 P49757,Q9H1H9 480 7.44e-03 171 4 2 0.500 0.012 GO:0007018 BP 1 microtubule-based movement 1 Q9H1H9,Q96CW1 480 8.02e-03 4 4 1 0.250 0.250 GO:0021873 BP 1 forebrain neuroblast division 1 P49757 480 8.02e-03 4 4 1 0.250 0.250 GO:0021670 BP 1 lateral ventricle development 1 P49757 480 8.15e-03 26 4 1 0.250 0.038 TF:M06421_0 tf 1 Factor: ZNF534; motif: KGGGAGAAAACM; match class: 0 1 P49757 480 8.15e-03 26 4 1 0.250 0.038 TF:M06989_0 tf 1 Factor: ZNF236; motif: MGTAATATTRA; match class: 0 1 Q96JQ2 480 8.81e-03 441 4 2 0.500 0.005 MI:hsa-miR-147b mi 1 MI:hsa-miR-147b 1 Q9H1H9,Q96CW1 480 8.98e-03 1728 4 3 0.750 0.002 TF:M07351_0 tf 1 Factor: COE1; motif: NNTCCCYTGRGNN; match class: 0 1 P49757,Q9H1H9,Q96CW1 480 9.04e-03 447 4 2 0.500 0.004 MI:hsa-miR-146b-5p mi 1 MI:hsa-miR-146b-5p 1 Q9H1H9,Q96JQ2 480 9.14e-03 1739 4 3 0.750 0.002 TF:M07042_1 tf 1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 1 P49757,Q9H1H9,Q96JQ2 480 9.60e-03 524 4 2 0.500 0.004 TF:M00690_1 tf 1 Factor: AP-3; motif: TCYMMATT; match class: 1 1 P49757,Q96CW1 480 9.71e-03 31 4 1 0.250 0.032 TF:M03964_0 tf 1 Factor: EBF1; motif: ANTCCCNWGGGAMT; match class: 0 1 Q96CW1 480 1.00e-02 5 4 1 0.250 0.200 GO:0072386 BP 1 plus-end-directed organelle transport along microtubule 1 Q9H1H9 480 1.00e-02 5 4 1 0.250 0.200 GO:0072383 BP 1 plus-end-directed vesicle transport along microtubule 1 Q9H1H9 480 1.00e-02 199 4 2 0.500 0.010 GO:0010008 CC 1 endosome membrane 1 Q9H1H9,Q96CW1 480 1.04e-02 6 4 1 0.250 0.167 REAC:182218 rea 1 Nef Mediated CD8 Down-regulation 1 Q96CW1 480 1.07e-02 910 4 3 0.750 0.003 GO:0097708 CC 1 intracellular vesicle 1 P49757,Q9H1H9,Q96CW1 480 1.10e-02 1857 4 3 0.750 0.002 TF:M02036_1 tf 1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 1.13e-02 36 4 1 0.250 0.028 TF:M06115_0 tf 1 Factor: ZNF28; motif: NGGGGCGGCAGC; match class: 0 1 P49757 480 1.13e-02 570 4 2 0.500 0.004 TF:M02022_0 tf 1 Factor: MafK; motif: TGASTCAGCDN; match class: 0 1 P49757,Q96CW1 480 1.14e-02 931 4 3 0.750 0.003 GO:0031410 CC 1 cytoplasmic vesicle 1 P49757,Q9H1H9,Q96CW1 480 1.20e-02 6 4 1 0.250 0.167 GO:0021591 BP 1 ventricular system development 1 P49757 480 1.22e-02 592 4 2 0.500 0.003 TF:M00174_1 tf 1 Factor: AP-1; motif: NNTGACTCANN; match class: 1 1 P49757,Q96CW1 480 1.29e-02 1962 4 3 0.750 0.002 TF:M01595_0 tf 1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 0 1 P49757,Q9H1H9,Q96CW1 480 1.30e-02 227 4 2 0.500 0.009 GO:0044440 CC 1 endosomal part 1 Q9H1H9,Q96CW1 480 1.32e-02 1976 4 3 0.750 0.002 TF:M06069_0 tf 1 Factor: ZNF253; motif: KKGCARMMGM; match class: 0 1 P49757,Q9H1H9,Q96CW1 480 1.39e-02 8 4 1 0.250 0.125 REAC:167590 rea 1 Nef Mediated CD4 Down-regulation 1 Q96CW1 480 1.40e-02 7 4 1 0.250 0.143 GO:0035459 BP 1 cargo loading into vesicle 1 Q9H1H9 480 1.45e-02 570 4 2 0.500 0.004 MI:hsa-miR-520d-5p mi 1 MI:hsa-miR-520d-5p 1 Q96CW1,Q96JQ2 480 1.47e-02 1016 4 3 0.750 0.003 GO:0006928 BP 1 movement of cell or subcellular component 1 P49757,Q9H1H9,Q96CW1 480 1.56e-02 9 4 1 0.250 0.111 REAC:196025 rea 1 Formation of annular gap junctions 1 Q96CW1 480 1.60e-02 8 4 1 0.250 0.125 GO:0036020 CC 1 endolysosome membrane 1 Q96CW1 480 1.60e-02 8 4 1 0.250 0.125 GO:0021846 BP 1 cell proliferation in forebrain 1 P49757 480 1.62e-02 52 4 1 0.250 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 Q96CW1 480 1.64e-02 4559 4 4 1.000 0.001 TF:M07409_0 tf 1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 1.68e-02 2151 4 3 0.750 0.001 TF:M07316_1 tf 1 Factor: C/EBPdelta; motif: TKNNGCAATN; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 1.72e-02 55 4 1 0.250 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 Q96CW1 480 1.73e-02 10 4 1 0.250 0.100 REAC:190873 rea 1 Gap junction degradation 1 Q96CW1 480 1.78e-02 57 4 1 0.250 0.018 TF:M05702_0 tf 1 Factor: ZNF-20; motif: KGGTACAAATCA; match class: 0 1 P49757 480 1.80e-02 9 4 1 0.250 0.111 GO:0055057 BP 1 neuroblast division 1 P49757 480 1.80e-02 9 4 1 0.250 0.111 GO:0036445 BP 1 neuronal stem cell division 1 P49757 480 1.80e-02 9 4 1 0.250 0.111 GO:0098748 MF 1 endocytic adaptor activity 1 Q96CW1 480 1.80e-02 9 4 1 0.250 0.111 GO:0035615 MF 1 clathrin adaptor activity 1 Q96CW1 480 1.83e-02 2213 4 3 0.750 0.001 TF:M07065_1 tf 1 Factor: STAT3; motif: TTCYGGGAAN; match class: 1 1 P49757,Q9H1H9,Q96JQ2 480 1.87e-02 4706 4 4 1.000 0.001 TF:M00059_1 tf 1 Factor: YY1; motif: NNNNNCCATNTWNNNWN; match class: 1 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 1.87e-02 60 4 1 0.250 0.017 TF:M05573_0 tf 1 Factor: ZNF213; motif: NATGCCTRCMGM; match class: 0 1 Q96CW1 480 1.90e-02 61 4 1 0.250 0.016 TF:M05443_0 tf 1 Factor: TBX15; motif: AGGTGTGAAAN; match class: 0 1 P49757 480 1.91e-02 1111 4 3 0.750 0.003 GO:0034613 BP 1 cellular protein localization 1 P49757,Q9H1H9,Q96CW1 480 1.93e-02 62 4 1 0.250 0.016 TF:M06525_0 tf 1 Factor: ZNF431; motif: NGKTWGGGCAGA; match class: 0 1 Q96CW1 480 1.96e-02 1121 4 3 0.750 0.003 GO:0070727 BP 1 cellular macromolecule localization 1 P49757,Q9H1H9,Q96CW1 480 2.00e-02 10 4 1 0.250 0.100 GO:0030128 CC 1 clathrin coat of endocytic vesicle 1 Q96CW1 480 2.00e-02 10 4 1 0.250 0.100 GO:0030122 CC 1 AP-2 adaptor complex 1 Q96CW1 480 2.03e-02 2296 4 3 0.750 0.001 TF:M07037_1 tf 1 Factor: C/EBPalpha; motif: NNNNNTTKCNNAAN; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 2.07e-02 2314 4 3 0.750 0.001 TF:M01735_0 tf 1 Factor: PITX3; motif: NGGATTANM; match class: 0 1 P49757,Q96CW1,Q96JQ2 480 2.08e-02 12 4 1 0.250 0.083 REAC:5140745 rea 1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 1 Q96CW1 480 2.12e-02 68 4 1 0.250 0.015 TF:M06370_0 tf 1 Factor: ZNF585A; motif: ACTWTCKAWAGG; match class: 0 1 Q96CW1 480 2.12e-02 68 4 1 0.250 0.015 TF:M06636_0 tf 1 Factor: ZNF599; motif: NRGAGTGTGGGC; match class: 0 1 P49757 480 2.12e-02 68 4 1 0.250 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 Q96CW1 480 2.15e-02 4876 4 4 1.000 0.001 TF:M07064_0 tf 1 Factor: STAT1; motif: TTCNRGGAAN; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 2.20e-02 11 4 1 0.250 0.091 GO:0048103 BP 1 somatic stem cell division 1 P49757 480 2.20e-02 11 4 1 0.250 0.091 GO:0036019 CC 1 endolysosome 1 Q96CW1 480 2.20e-02 11 4 1 0.250 0.091 GO:0030132 CC 1 clathrin coat of coated pit 1 Q96CW1 480 2.25e-02 13 4 1 0.250 0.077 REAC:177504 rea 1 Retrograde neurotrophin signalling 1 Q96CW1 480 2.34e-02 75 4 1 0.250 0.013 TF:M06020_0 tf 1 Factor: ZBTB40; motif: NGGTCCTRRTCC; match class: 0 1 Q96JQ2 480 2.40e-02 77 4 1 0.250 0.013 TF:M04223_1 tf 1 Factor: NFIL3; motif: NRTTACRTAAYN; match class: 1 1 P49757 480 2.40e-02 12 4 1 0.250 0.083 GO:0050750 MF 1 low-density lipoprotein particle receptor binding 1 Q96CW1 480 2.42e-02 5021 4 4 1.000 0.001 TF:M07208_0 tf 1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 2.42e-02 14 4 1 0.250 0.071 REAC:5099900 rea 1 WNT5A-dependent internalization of FZD4 1 Q96CW1 480 2.42e-02 14 4 1 0.250 0.071 REAC:190828 rea 1 Gap junction trafficking 1 Q96CW1 480 2.42e-02 5023 4 4 1.000 0.001 TF:M07060_1 tf 1 Factor: POU4F1; motif: TRTTAAYTNN; match class: 1 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 2.50e-02 3 4 1 0.250 0.333 CORUM:3172 cor 1 NUMB-TP53-MDM2 complex 1 P49757 480 2.59e-02 15 4 1 0.250 0.067 REAC:171052 rea 1 LDL-mediated lipid transport 1 Q96CW1 480 2.59e-02 15 4 1 0.250 0.067 REAC:416993 rea 1 Trafficking of GluR2-containing AMPA receptors 1 Q96CW1 480 2.77e-02 16 4 1 0.250 0.062 REAC:157858 rea 1 Gap junction trafficking and regulation 1 Q96CW1 480 2.80e-02 14 4 1 0.250 0.071 GO:0030131 CC 1 clathrin adaptor complex 1 Q96CW1 480 2.85e-02 2588 4 3 0.750 0.001 TF:M03870_1 tf 1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 2.95e-02 5275 4 4 1.000 0.001 TF:M01100_1 tf 1 Factor: LRF; motif: VNNRMCCCC; match class: 1 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 3.00e-02 15 4 1 0.250 0.067 GO:0017145 BP 1 stem cell division 1 P49757 480 3.04e-02 2649 4 3 0.750 0.001 TF:M04632_1 tf 1 Factor: SREBP-1; motif: NNNGTGGGGTGAN; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 3.09e-02 962 4 2 0.500 0.002 TF:M03825_0 tf 1 Factor: Gfi1b; motif: YYCAATCWSD; match class: 0 1 Q9H1H9,Q96JQ2 480 3.11e-02 18 4 1 0.250 0.056 REAC:164938 rea 1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1 Q96CW1 480 3.20e-02 16 4 1 0.250 0.062 GO:0070325 MF 1 lipoprotein particle receptor binding 1 Q96CW1 480 3.22e-02 359 4 2 0.500 0.006 GO:0051129 BP 1 negative regulation of cellular component organization 1 P49757,Q96CW1 480 3.23e-02 104 4 1 0.250 0.010 TF:M06750_0 tf 1 Factor: ZNF510; motif: NTKGGAAAAARA; match class: 0 1 Q96JQ2 480 3.24e-02 5402 4 4 1.000 0.001 TF:M01104_1 tf 1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 3.38e-02 368 4 2 0.500 0.005 GO:1903827 BP 1 regulation of cellular protein localization 1 P49757,Q96CW1 480 3.40e-02 5466 4 4 1.000 0.001 TF:M00470_1 tf 1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 3.41e-02 110 4 1 0.250 0.009 TF:M04058_0 tf 1 Factor: NFIX; motif: YTGGCNNNNTGCCAA; match class: 0 1 P49757 480 3.41e-02 110 4 1 0.250 0.009 TF:M06215_0 tf 1 Factor: ZNF33b; motif: NTGTCCAANGGA; match class: 0 1 P49757 480 3.41e-02 110 4 1 0.250 0.009 TF:M01142_1 tf 1 Factor: LRH1; motif: NNRRCCTTGVAN; match class: 1 1 Q96JQ2 480 3.51e-02 1029 4 2 0.500 0.002 TF:M02059_0 tf 1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 0 1 Q96CW1,Q96JQ2 480 3.52e-02 5512 4 4 1.000 0.001 TF:M00806_0 tf 1 Factor: NF-1; motif: NTGGNNNNNNGCCAANN; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 3.60e-02 2813 4 3 0.750 0.001 TF:M04625_0 tf 1 Factor: PLZF; motif: ACTKTANNTN; match class: 0 1 P49757,Q9H1H9,Q96JQ2 480 3.60e-02 18 4 1 0.250 0.056 GO:0030125 CC 1 clathrin vesicle coat 1 Q96CW1 480 3.63e-02 117 4 1 0.250 0.009 TF:M00528_1 tf 1 Factor: PPAR; motif: WASNRGGNCAAAGGTCA; match class: 1 1 Q9H1H9 480 3.66e-02 2831 4 3 0.750 0.001 TF:M01273_0 tf 1 Factor: SP4; motif: SCCCCGCCCCS; match class: 0 1 Q9H1H9,Q96CW1,Q96JQ2 480 3.70e-02 2840 4 3 0.750 0.001 TF:M07329_1 tf 1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 1 Q9H1H9,Q96CW1,Q96JQ2 480 3.70e-02 1393 4 3 0.750 0.002 GO:0008104 BP 1 protein localization 1 P49757,Q9H1H9,Q96CW1 480 3.71e-02 1060 4 2 0.500 0.002 TF:M05427_0 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 0 1 Q96CW1,Q96JQ2 480 3.78e-02 122 4 1 0.250 0.008 TF:M07092_0 tf 1 Factor: Fra-2; motif: NRRTGASTCAB; match class: 0 1 P49757 480 3.81e-02 123 4 1 0.250 0.008 TF:M00261_0 tf 1 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN; match class: 0 1 Q96CW1 480 3.86e-02 1082 4 2 0.500 0.002 TF:M07278_1 tf 1 Factor: Dlx3; motif: NTAATTNVN; match class: 1 1 P49757,Q96CW1 480 3.90e-02 2454 4 3 0.750 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 P49757,Q9H1H9,Q96JQ2 480 3.93e-02 127 4 1 0.250 0.008 TF:M06283_0 tf 1 Factor: ZNF678; motif: NKGGAMGGCAGC; match class: 0 1 Q9H1H9 480 3.97e-02 23 4 1 0.250 0.043 REAC:2122948 rea 1 Activated NOTCH1 Transmits Signal to the Nucleus 1 P49757 480 4.02e-02 130 4 1 0.250 0.008 TF:M07210_1 tf 1 Factor: ESR2; motif: AGGTCASNNTGNCCY; match class: 1 1 Q96CW1 480 4.15e-02 134 4 1 0.250 0.007 TF:M06928_0 tf 1 Factor: Smad7; motif: GTTTNGYCAAAT; match class: 0 1 Q9H1H9 480 4.20e-02 21 4 1 0.250 0.048 GO:0032438 BP 1 melanosome organization 1 Q9H1H9 480 4.20e-02 21 4 1 0.250 0.048 GO:0021872 BP 1 forebrain generation of neurons 1 P49757 480 4.20e-02 21 4 1 0.250 0.048 GO:0048753 BP 1 pigment granule organization 1 Q9H1H9 480 4.23e-02 2527 4 3 0.750 0.001 HPA:005010_03 hpa 1 bronchus; respiratory epithelial cells[Uncertain,High] 1 P49757,Q9H1H9,Q96JQ2 480 4.27e-02 2990 4 3 0.750 0.001 TF:M00042_1 tf 1 Factor: SOX5; motif: NNAACAATNN; match class: 1 1 P49757,Q9H1H9,Q96CW1 480 4.30e-02 139 4 1 0.250 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q96CW1 480 4.31e-02 25 4 1 0.250 0.040 REAC:164952 rea 1 The role of Nef in HIV-1 replication and disease pathogenesis 1 Q96CW1 480 4.33e-02 140 4 1 0.250 0.007 TF:M00437_0 tf 1 Factor: CHX10; motif: NNNTAATTAGCNNN; match class: 0 1 P49757 480 4.40e-02 22 4 1 0.250 0.045 GO:0007405 BP 1 neuroblast proliferation 1 P49757 480 4.45e-02 3035 4 3 0.750 0.001 TF:M01873_1 tf 1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 1 P49757,Q96CW1,Q96JQ2 480 4.46e-02 1169 4 2 0.500 0.002 TF:M03972_0 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 0 1 Q96CW1,Q96JQ2 480 4.48e-02 145 4 1 0.250 0.007 TF:M02377_1 tf 1 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN; match class: 1 1 Q96CW1 480 4.51e-02 3049 4 3 0.750 0.001 TF:M01219_0 tf 1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 0 1 P49757,Q96CW1,Q96JQ2 480 4.52e-02 3052 4 3 0.750 0.001 TF:M00469_1 tf 1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 1 Q9H1H9,Q96CW1,Q96JQ2 480 4.52e-02 3052 4 3 0.750 0.001 TF:M07284_1 tf 1 Factor: Erg; motif: MCAGGAAA; match class: 1 1 P49757,Q9H1H9,Q96CW1 480 4.54e-02 147 4 1 0.250 0.007 TF:M05303_0 tf 1 Factor: ZNF536; motif: NCWGSTGCTA; match class: 0 1 Q9H1H9 480 4.57e-02 148 4 1 0.250 0.007 TF:M04225_0 tf 1 Factor: TEF; motif: NRTTACRTAAYN; match class: 0 1 P49757 480 4.57e-02 148 4 1 0.250 0.007 TF:M06633_0 tf 1 Factor: ZNF717; motif: NGGTGARRAAGA; match class: 0 1 P49757 480 4.59e-02 1187 4 2 0.500 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 P49757,Q9H1H9 480 4.60e-02 5896 4 4 1.000 0.001 TF:M00626_0 tf 1 Factor: RFX1; motif: MRWYRCYAKGSAAM; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 4.72e-02 153 4 1 0.250 0.007 TF:M01145_1 tf 1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 1 Q96JQ2 480 4.74e-02 1207 4 2 0.500 0.002 TF:M01728_0 tf 1 Factor: EAR2; motif: YGNNCTTTGNCCTK; match class: 0 1 P49757,Q9H1H9 480 4.82e-02 1219 4 2 0.500 0.002 TF:M00074_1 tf 1 Factor: c-Ets-1(p54); motif: NNACMGGAWRTNN; match class: 1 1 Q96CW1,Q96JQ2 480 4.83e-02 5967 4 4 1.000 0.001 TF:M01821_0 tf 1 Factor: c-Myb; motif: NNNAACKGNNN; match class: 0 1 P49757,Q9H1H9,Q96CW1,Q96JQ2 480 4.87e-02 1225 4 2 0.500 0.002 TF:M04398_0 tf 1 Factor: MEOX1; motif: NSTAATTANN; match class: 0 1 P49757,Q96JQ2 480 5.00e-02 29 4 1 0.250 0.034 REAC:399719 rea 1 Trafficking of AMPA receptors 1 Q96CW1 480 5.00e-02 39 4 1 0.250 0.026 KEGG:04330 keg 1 Notch signaling pathway 1 P49757 480 5.00e-02 6 4 1 0.250 0.167 CORUM:247 cor 1 RalBP1-CCNB1-AP2A-NUMB-EPN1 complex 1 P49757 480 5.00e-02 29 4 1 0.250 0.034 REAC:399721 rea 1 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 1 Q96CW1 480 5.00e-02 25 4 1 0.250 0.040 GO:0030118 CC 1 clathrin coat 1 Q96CW1 480 5.00e-02 25 4 1 0.250 0.040 GO:0050690 BP 1 regulation of defense response to virus by virus 1 Q96CW1 481 2.40e-03 320 3 2 0.667 0.006 MI:hsa-miR-593 mi 1 MI:hsa-miR-593 1 Q9BSE2,O14983 481 3.13e-03 1 3 1 0.333 1.000 GO:0031448 BP 1 positive regulation of fast-twitch skeletal muscle fiber contraction 1 O14983 481 3.13e-03 1 3 1 0.333 1.000 GO:0031446 BP 1 regulation of fast-twitch skeletal muscle fiber contraction 1 O14983 481 3.13e-03 1 3 1 0.333 1.000 GO:0090076 BP 1 relaxation of skeletal muscle 1 O14983 481 3.13e-03 1 3 1 0.333 1.000 GO:0031443 BP 1 fast-twitch skeletal muscle fiber contraction 1 O14983 481 3.13e-03 1 3 1 0.333 1.000 GO:0002070 BP 1 epithelial cell maturation 1 Q9BSE2 481 3.47e-03 386 3 2 0.667 0.005 MI:hsa-miR-624 mi 1 MI:hsa-miR-624 1 Q9BSE2,O14983 481 3.75e-03 783 3 3 1.000 0.004 GO:0042592 BP 1 homeostatic process 1 Q8N0V5,Q9BSE2,O14983 481 4.80e-03 134 3 2 0.667 0.015 GO:0048871 BP 1 multicellular organismal homeostasis 1 Q8N0V5,Q9BSE2 481 5.10e-03 469 3 2 0.667 0.004 MI:hsa-miR-562 mi 1 MI:hsa-miR-562 1 Q9BSE2,O14983 481 6.26e-03 2 3 1 0.333 0.500 GO:0051659 BP 1 maintenance of mitochondrion location 1 O14983 481 6.26e-03 2 3 1 0.333 0.500 GO:0014721 BP 1 twitch skeletal muscle contraction 1 O14983 481 6.26e-03 2 3 1 0.333 0.500 GO:0003010 BP 1 voluntary skeletal muscle contraction 1 O14983 481 6.26e-03 2 3 1 0.333 0.500 GO:0014724 BP 1 regulation of twitch skeletal muscle contraction 1 O14983 481 6.26e-03 2 3 1 0.333 0.500 GO:0032470 BP 1 positive regulation of endoplasmic reticulum calcium ion concentration 1 O14983 481 8.13e-03 594 3 2 0.667 0.003 MI:mmu-miR-466b-5p mi 1 MI:mmu-miR-466b-5p 1 Q9BSE2,O14983 481 9.39e-03 3 3 1 0.333 0.333 GO:0008109 MF 1 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity 1 Q8N0V5 481 1.25e-02 4 3 1 0.333 0.250 GO:0036438 BP 1 maintenance of lens transparency 1 Q8N0V5 481 1.45e-02 11 3 1 0.333 0.091 REAC:418359 rea 1 Reduction of cytosolic Ca++ levels 1 O14983 481 1.56e-02 5 3 1 0.333 0.200 GO:0032471 BP 1 negative regulation of endoplasmic reticulum calcium ion concentration 1 O14983 481 1.56e-02 5 3 1 0.333 0.200 GO:0045989 BP 1 positive regulation of striated muscle contraction 1 O14983 481 1.88e-02 6 3 1 0.333 0.167 GO:0051657 BP 1 maintenance of organelle location 1 O14983 481 2.19e-02 7 3 1 0.333 0.143 GO:0051561 BP 1 positive regulation of mitochondrial calcium ion concentration 1 O14983 481 2.37e-02 18 3 1 0.333 0.056 REAC:1912420 rea 1 Pre-NOTCH Processing in Golgi 1 O14983 481 2.50e-02 8 3 1 0.333 0.125 GO:0034116 BP 1 positive regulation of heterotypic cell-cell adhesion 1 Q8N0V5 481 2.50e-02 8 3 1 0.333 0.125 GO:0014819 BP 1 regulation of skeletal muscle contraction 1 O14983 481 2.50e-02 2 3 1 0.333 0.500 HP:0010970 hp 1 Blood group antigen abnormality 1 Q8N0V5 481 2.77e-02 21 3 1 0.333 0.048 REAC:418360 rea 1 Platelet calcium homeostasis 1 O14983 481 2.81e-02 9 3 1 0.333 0.111 GO:0031094 CC 1 platelet dense tubular network 1 O14983 481 2.81e-02 9 3 1 0.333 0.111 GO:0005388 MF 1 calcium-transporting ATPase activity 1 O14983 481 2.81e-02 9 3 1 0.333 0.111 GO:0033561 BP 1 regulation of water loss via skin 1 Q9BSE2 481 2.81e-02 9 3 1 0.333 0.111 GO:0061436 BP 1 establishment of skin barrier 1 Q9BSE2 481 2.81e-02 9 3 1 0.333 0.111 GO:0031095 CC 1 platelet dense tubular network membrane 1 O14983 481 3.44e-02 11 3 1 0.333 0.091 GO:0045684 BP 1 positive regulation of epidermis development 1 Q9BSE2 481 3.63e-02 137 3 2 0.667 0.015 TF:M06701_0 tf 1 Factor: ZNF319; motif: NGGTWAAACCGA; match class: 0 1 Q9BSE2,O14983 481 3.75e-02 12 3 1 0.333 0.083 GO:0090075 BP 1 relaxation of muscle 1 O14983 481 3.75e-02 12 3 1 0.333 0.083 GO:0045933 BP 1 positive regulation of muscle contraction 1 O14983 481 3.75e-02 3 3 1 0.333 0.333 HP:0100019 hp 1 Cortical cataract 1 Q8N0V5 481 3.75e-02 3 3 1 0.333 0.333 HP:0001118 hp 1 Juvenile cataract 1 Q8N0V5 481 4.38e-02 14 3 1 0.333 0.071 GO:0051560 BP 1 mitochondrial calcium ion homeostasis 1 O14983 481 5.00e-02 16 3 1 0.333 0.062 GO:0032469 BP 1 endoplasmic reticulum calcium ion homeostasis 1 O14983 481 5.00e-02 1 3 1 0.333 1.000 OMIM:601003 omi 1 BRODY MYOPATHY 1 O14983 481 5.00e-02 1 3 1 0.333 1.000 OMIM:110800 omi 1 BLOOD GROUP, I SYSTEM; Ii;;I BLOOD GROUP SYSTEM;;Ii BLOOD GROUP SYSTEMADULT i PHENOTYPE, INCLUDED 1 Q8N0V5 481 5.00e-02 38 3 1 0.333 0.026 REAC:5578775 rea 1 Ion homeostasis 1 O14983 481 5.00e-02 2 3 1 0.333 0.500 TF:M03904_1 tf 1 Factor: GLIS2; motif: GACCCCCCGCRANG; match class: 1 1 O14983 481 5.00e-02 4 3 1 0.333 0.250 HP:0007834 hp 1 Progressive cataract 1 Q8N0V5 481 5.00e-02 19 3 1 0.333 0.053 KEGG:00601 keg 1 Glycosphingolipid biosynthesis - lacto and neolacto series 1 Q8N0V5 481 5.00e-02 1 3 1 0.333 1.000 OMIM:116700 omi 1 CATARACT 13 WITH ADULT i PHENOTYPE; CTRCT13 1 Q8N0V5 481 5.00e-02 16 3 1 0.333 0.062 GO:0034114 BP 1 regulation of heterotypic cell-cell adhesion 1 Q8N0V5 482 5.61e-09 16 3 3 1.000 0.188 GO:0005942 CC 1 phosphatidylinositol 3-kinase complex 1 O00459,Q92569,P42336 482 1.15e-08 17 3 3 1.000 0.176 REAC:389357 rea 1 CD28 dependent PI3K/Akt signaling 1 O00459,Q92569,P42336 482 1.15e-08 17 3 3 1.000 0.176 REAC:912631 rea 1 Regulation of signaling by CBL 1 O00459,Q92569,P42336 482 4.06e-08 30 3 3 1.000 0.100 GO:0016303 MF 1 1-phosphatidylinositol-3-kinase activity 1 O00459,Q92569,P42336 482 5.54e-08 28 3 3 1.000 0.107 REAC:389356 rea 1 CD28 co-stimulation 1 O00459,Q92569,P42336 482 6.55e-08 35 3 3 1.000 0.086 GO:0052742 MF 1 phosphatidylinositol kinase activity 1 O00459,Q92569,P42336 482 1.11e-07 35 3 3 1.000 0.086 REAC:392451 rea 1 G beta:gamma signalling through PI3Kgamma 1 O00459,Q92569,P42336 482 1.32e-07 37 3 3 1.000 0.081 REAC:114604 rea 1 GPVI-mediated activation cascade 1 O00459,Q92569,P42336 482 1.43e-07 38 3 3 1.000 0.079 REAC:397795 rea 1 G-protein beta:gamma signalling 1 O00459,Q92569,P42336 482 1.52e-07 46 3 3 1.000 0.065 GO:0035004 MF 1 phosphatidylinositol 3-kinase activity 1 O00459,Q92569,P42336 482 2.24e-07 44 3 3 1.000 0.068 REAC:1660499 rea 1 Synthesis of PIPs at the plasma membrane 1 O00459,Q92569,P42336 482 2.24e-07 44 3 3 1.000 0.068 REAC:2219530 rea 1 Constitutive Signaling by Aberrant PI3K in Cancer 1 O00459,Q92569,P42336 482 2.70e-07 31 3 3 1.000 0.097 KEGG:04960 keg 1 Aldosterone-regulated sodium reabsorption 1 O00459,Q92569,P42336 482 3.27e-07 33 3 3 1.000 0.091 KEGG:04973 keg 1 Carbohydrate digestion and absorption 1 O00459,Q92569,P42336 482 3.97e-07 53 3 3 1.000 0.057 REAC:388841 rea 1 Costimulation by the CD28 family 1 O00459,Q92569,P42336 482 5.06e-07 38 3 3 1.000 0.079 KEGG:04923 keg 1 Regulation of lipolysis in adipocytes 1 O00459,Q92569,P42336 482 6.88e-07 42 3 3 1.000 0.071 KEGG:04930 keg 1 Type II diabetes mellitus 1 O00459,Q92569,P42336 482 6.93e-07 4 3 2 0.667 0.500 GO:0035014 MF 1 phosphatidylinositol 3-kinase regulator activity 1 O00459,Q92569 482 6.93e-07 4 3 2 0.667 0.500 GO:0046935 MF 1 1-phosphatidylinositol-3-kinase regulator activity 1 O00459,Q92569 482 7.05e-07 64 3 3 1.000 0.047 REAC:6811558 rea 1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1 O00459,Q92569,P42336 482 7.92e-07 79 3 3 1.000 0.038 GO:0008286 BP 1 insulin receptor signaling pathway 1 O00459,Q92569,P42336 482 8.11e-07 67 3 3 1.000 0.045 REAC:2219528 rea 1 PI3K/AKT Signaling in Cancer 1 O00459,Q92569,P42336 482 8.22e-07 80 3 3 1.000 0.037 GO:0006661 BP 1 phosphatidylinositol biosynthetic process 1 O00459,Q92569,P42336 482 8.48e-07 68 3 3 1.000 0.044 REAC:1483255 rea 1 PI Metabolism 1 O00459,Q92569,P42336 482 9.67e-07 71 3 3 1.000 0.042 REAC:199418 rea 1 Negative regulation of the PI3K/AKT network 1 O00459,Q92569,P42336 482 1.05e-06 73 3 3 1.000 0.041 REAC:416482 rea 1 G alpha (12/13) signalling events 1 O00459,Q92569,P42336 482 1.10e-06 49 3 3 1.000 0.061 KEGG:05213 keg 1 Endometrial cancer 1 O00459,Q92569,P42336 482 1.15e-06 5 3 2 0.667 0.400 GO:2001275 BP 1 positive regulation of glucose import in response to insulin stimulus 1 O00459,Q92569 482 1.33e-06 52 3 3 1.000 0.058 KEGG:05221 keg 1 Acute myeloid leukemia 1 O00459,Q92569,P42336 482 1.33e-06 52 3 3 1.000 0.058 KEGG:05223 keg 1 Non-small cell lung cancer 1 O00459,Q92569,P42336 482 1.49e-06 54 3 3 1.000 0.056 KEGG:05218 keg 1 Melanoma 1 O00459,Q92569,P42336 482 1.49e-06 54 3 3 1.000 0.056 KEGG:04664 keg 1 Fc epsilon RI signaling pathway 1 O00459,Q92569,P42336 482 1.49e-06 54 3 3 1.000 0.056 KEGG:04370 keg 1 VEGF signaling pathway 1 O00459,Q92569,P42336 482 1.66e-06 56 3 3 1.000 0.054 KEGG:04917 keg 1 Prolactin signaling pathway 1 O00459,Q92569,P42336 482 1.72e-06 102 3 3 1.000 0.029 GO:0046488 BP 1 phosphatidylinositol metabolic process 1 O00459,Q92569,P42336 482 1.73e-06 6 3 2 0.667 0.333 GO:0044381 BP 1 glucose import in response to insulin stimulus 1 O00459,Q92569 482 1.73e-06 6 3 2 0.667 0.333 GO:2001273 BP 1 regulation of glucose import in response to insulin stimulus 1 O00459,Q92569 482 1.75e-06 57 3 3 1.000 0.053 KEGG:05214 keg 1 Glioma 1 O00459,Q92569,P42336 482 1.75e-06 57 3 3 1.000 0.053 KEGG:04213 keg 1 Longevity regulating pathway - multiple species 1 O00459,Q92569,P42336 482 1.85e-06 58 3 3 1.000 0.052 KEGG:05210 keg 1 Colorectal cancer 1 O00459,Q92569,P42336 482 1.86e-06 88 3 3 1.000 0.034 REAC:416476 rea 1 G alpha (q) signalling events 1 O00459,Q92569,P42336 482 1.95e-06 59 3 3 1.000 0.051 KEGG:05211 keg 1 Renal cell carcinoma 1 O00459,Q92569,P42336 482 1.95e-06 59 3 3 1.000 0.051 KEGG:04662 keg 1 B cell receptor signaling pathway 1 O00459,Q92569,P42336 482 2.10e-06 109 3 3 1.000 0.028 GO:0032869 BP 1 cellular response to insulin stimulus 1 O00459,Q92569,P42336 482 2.16e-06 61 3 3 1.000 0.049 KEGG:05212 keg 1 Pancreatic cancer 1 O00459,Q92569,P42336 482 2.41e-06 114 3 3 1.000 0.026 GO:0032868 BP 1 response to insulin 1 O00459,Q92569,P42336 482 2.42e-06 7 3 2 0.667 0.286 GO:1900078 BP 1 positive regulation of cellular response to insulin stimulus 1 O00459,Q92569 482 2.50e-06 64 3 3 1.000 0.047 KEGG:05230 keg 1 Central carbon metabolism in cancer 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:5654710 rea 1 PI-3K cascade:FGFR3 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:1257604 rea 1 PIP3 activates AKT signaling 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:5654689 rea 1 PI-3K cascade:FGFR1 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:5654720 rea 1 PI-3K cascade:FGFR4 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:5654695 rea 1 PI-3K cascade:FGFR2 1 O00459,Q92569,P42336 482 2.74e-06 100 3 3 1.000 0.030 REAC:1250342 rea 1 PI3K events in ERBB4 signaling 1 O00459,Q92569,P42336 482 2.91e-06 102 3 3 1.000 0.029 REAC:198203 rea 1 PI3K/AKT activation 1 O00459,Q92569,P42336 482 2.99e-06 103 3 3 1.000 0.029 REAC:180292 rea 1 GAB1 signalosome 1 O00459,Q92569,P42336 482 3.14e-06 69 3 3 1.000 0.043 KEGG:05220 keg 1 Chronic myeloid leukemia 1 O00459,Q92569,P42336 482 3.17e-06 105 3 3 1.000 0.029 REAC:2730905 rea 1 Role of LAT2/NTAL/LAB on calcium mobilization 1 O00459,Q92569,P42336 482 3.28e-06 70 3 3 1.000 0.043 KEGG:04620 keg 1 Toll-like receptor signaling pathway 1 O00459,Q92569,P42336 482 3.43e-06 71 3 3 1.000 0.042 KEGG:01524 keg 1 Platinum drug resistance 1 O00459,Q92569,P42336 482 3.58e-06 72 3 3 1.000 0.042 KEGG:04750 keg 1 Inflammatory mediator regulation of TRP channels 1 O00459,Q92569,P42336 482 3.73e-06 73 3 3 1.000 0.041 KEGG:05100 keg 1 Bacterial invasion of epithelial cells 1 O00459,Q92569,P42336 482 3.73e-06 73 3 3 1.000 0.041 KEGG:01521 keg 1 EGFR tyrosine kinase inhibitor resistance 1 O00459,Q92569,P42336 482 4.21e-06 76 3 3 1.000 0.039 KEGG:05146 keg 1 Amoebiasis 1 O00459,Q92569,P42336 482 4.21e-06 76 3 3 1.000 0.039 KEGG:04670 keg 1 Leukocyte transendothelial migration 1 O00459,Q92569,P42336 482 4.39e-06 77 3 3 1.000 0.039 KEGG:05215 keg 1 Prostate cancer 1 O00459,Q92569,P42336 482 4.56e-06 78 3 3 1.000 0.038 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 O00459,Q92569,P42336 482 4.74e-06 79 3 3 1.000 0.038 KEGG:04668 keg 1 TNF signaling pathway 1 O00459,Q92569,P42336 482 4.88e-06 144 3 3 1.000 0.021 GO:0046474 BP 1 glycerophospholipid biosynthetic process 1 O00459,Q92569,P42336 482 4.93e-06 80 3 3 1.000 0.037 KEGG:04012 keg 1 ErbB signaling pathway 1 O00459,Q92569,P42336 482 4.93e-06 80 3 3 1.000 0.037 KEGG:04915 keg 1 Estrogen signaling pathway 1 O00459,Q92569,P42336 482 5.12e-06 81 3 3 1.000 0.037 KEGG:05142 keg 1 Chagas disease (American trypanosomiasis) 1 O00459,Q92569,P42336 482 5.31e-06 82 3 3 1.000 0.037 KEGG:04630 keg 1 Jak-STAT signaling pathway 1 O00459,Q92569,P42336 482 5.51e-06 83 3 3 1.000 0.036 KEGG:04211 keg 1 Longevity regulating pathway 1 O00459,Q92569,P42336 482 5.71e-06 84 3 3 1.000 0.036 KEGG:04650 keg 1 Natural killer cell mediated cytotoxicity 1 O00459,Q92569,P42336 482 5.71e-06 84 3 3 1.000 0.036 KEGG:05222 keg 1 Small cell lung cancer 1 O00459,Q92569,P42336 482 5.71e-06 84 3 3 1.000 0.036 KEGG:04660 keg 1 T cell receptor signaling pathway 1 O00459,Q92569,P42336 482 5.92e-06 85 3 3 1.000 0.035 KEGG:04666 keg 1 Fc gamma R-mediated phagocytosis 1 O00459,Q92569,P42336 482 6.14e-06 86 3 3 1.000 0.035 KEGG:05231 keg 1 Choline metabolism in cancer 1 O00459,Q92569,P42336 482 6.14e-06 86 3 3 1.000 0.035 KEGG:04933 keg 1 AGE-RAGE signaling pathway in diabetic complications 1 O00459,Q92569,P42336 482 6.14e-06 86 3 3 1.000 0.035 KEGG:04066 keg 1 HIF-1 signaling pathway 1 O00459,Q92569,P42336 482 6.36e-06 87 3 3 1.000 0.034 KEGG:01522 keg 1 Endocrine resistance 1 O00459,Q92569,P42336 482 6.46e-06 158 3 3 1.000 0.019 GO:0008654 BP 1 phospholipid biosynthetic process 1 O00459,Q92569,P42336 482 6.58e-06 88 3 3 1.000 0.034 KEGG:04725 keg 1 Cholinergic synapse 1 O00459,Q92569,P42336 482 6.81e-06 89 3 3 1.000 0.034 KEGG:04070 keg 1 Phosphatidylinositol signaling system 1 O00459,Q92569,P42336 482 7.04e-06 90 3 3 1.000 0.033 KEGG:04380 keg 1 Osteoclast differentiation 1 O00459,Q92569,P42336 482 7.09e-06 163 3 3 1.000 0.018 GO:0045017 BP 1 glycerolipid biosynthetic process 1 O00459,Q92569,P42336 482 7.49e-06 166 3 3 1.000 0.018 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 O00459,Q92569,P42336 482 7.53e-06 92 3 3 1.000 0.033 KEGG:05160 keg 1 Hepatitis C 1 O00459,Q92569,P42336 482 7.62e-06 12 3 2 0.667 0.167 GO:0046854 BP 1 phosphatidylinositol phosphorylation 1 O00459,P42336 482 8.06e-06 12 3 2 0.667 0.167 REAC:1266695 rea 1 Interleukin-7 signaling 1 O00459,Q92569 482 8.30e-06 95 3 3 1.000 0.032 KEGG:05145 keg 1 Toxoplasmosis 1 O00459,Q92569,P42336 482 8.34e-06 172 3 3 1.000 0.017 GO:1901653 BP 1 cellular response to peptide 1 O00459,Q92569,P42336 482 8.57e-06 96 3 3 1.000 0.031 KEGG:04931 keg 1 Insulin resistance 1 O00459,Q92569,P42336 482 8.94e-06 176 3 3 1.000 0.017 GO:0019898 CC 1 extrinsic component of membrane 1 O00459,Q92569,P42336 482 9.12e-06 98 3 3 1.000 0.031 KEGG:05162 keg 1 Measles 1 O00459,Q92569,P42336 482 9.73e-06 181 3 3 1.000 0.017 GO:0043434 BP 1 response to peptide hormone 1 O00459,Q92569,P42336 482 1.06e-05 103 3 3 1.000 0.029 KEGG:04611 keg 1 Platelet activation 1 O00459,Q92569,P42336 482 1.09e-05 104 3 3 1.000 0.029 KEGG:04722 keg 1 Neurotrophin signaling pathway 1 O00459,Q92569,P42336 482 1.09e-05 104 3 3 1.000 0.029 KEGG:04071 keg 1 Sphingolipid signaling pathway 1 O00459,Q92569,P42336 482 1.12e-05 105 3 3 1.000 0.029 KEGG:04919 keg 1 Thyroid hormone signaling pathway 1 O00459,Q92569,P42336 482 1.13e-05 190 3 3 1.000 0.016 GO:1901652 BP 1 response to peptide 1 O00459,Q92569,P42336 482 1.14e-05 191 3 3 1.000 0.016 GO:0006650 BP 1 glycerophospholipid metabolic process 1 O00459,Q92569,P42336 482 1.19e-05 107 3 3 1.000 0.028 KEGG:04152 keg 1 AMPK signaling pathway 1 O00459,Q92569,P42336 482 1.21e-05 15 3 2 0.667 0.133 GO:0046326 BP 1 positive regulation of glucose import 1 O00459,Q92569 482 1.22e-05 108 3 3 1.000 0.028 KEGG:04550 keg 1 Signaling pathways regulating pluripotency of stem cells 1 O00459,Q92569,P42336 482 1.24e-05 165 3 3 1.000 0.018 REAC:1483257 rea 1 Phospholipid metabolism 1 O00459,Q92569,P42336 482 1.31e-05 168 3 3 1.000 0.018 REAC:1168372 rea 1 Downstream signaling events of B Cell Receptor (BCR) 1 O00459,Q92569,P42336 482 1.33e-05 111 3 3 1.000 0.027 KEGG:04068 keg 1 FoxO signaling pathway 1 O00459,Q92569,P42336 482 1.37e-05 112 3 3 1.000 0.027 KEGG:05224 keg 1 Breast cancer 1 O00459,Q92569,P42336 482 1.47e-05 16 3 2 0.667 0.125 REAC:210993 rea 1 Tie2 Signaling 1 O00459,P42336 482 1.56e-05 117 3 3 1.000 0.026 KEGG:04072 keg 1 Phospholipase D signaling pathway 1 O00459,Q92569,P42336 482 1.57e-05 17 3 2 0.667 0.118 GO:0010828 BP 1 positive regulation of glucose transport 1 O00459,Q92569 482 1.60e-05 118 3 3 1.000 0.025 KEGG:04210 keg 1 Apoptosis 1 O00459,Q92569,P42336 482 1.66e-05 216 3 3 1.000 0.014 GO:0061695 CC 1 transferase complex, transferring phosphorus-containing groups 1 O00459,Q92569,P42336 482 1.68e-05 120 3 3 1.000 0.025 KEGG:04062 keg 1 Chemokine signaling pathway 1 O00459,Q92569,P42336 482 1.73e-05 121 3 3 1.000 0.025 KEGG:04910 keg 1 Insulin signaling pathway 1 O00459,Q92569,P42336 482 1.77e-05 122 3 3 1.000 0.025 KEGG:04261 keg 1 Adrenergic signaling in cardiomyocytes 1 O00459,Q92569,P42336 482 1.82e-05 187 3 3 1.000 0.016 REAC:983705 rea 1 Signaling by the B Cell Receptor (BCR) 1 O00459,Q92569,P42336 482 1.86e-05 124 3 3 1.000 0.024 KEGG:05161 keg 1 Hepatitis B 1 O00459,Q92569,P42336 482 1.91e-05 125 3 3 1.000 0.024 KEGG:04932 keg 1 Non-alcoholic fatty liver disease (NAFLD) 1 O00459,Q92569,P42336 482 2.10e-05 129 3 3 1.000 0.023 KEGG:05164 keg 1 Influenza A 1 O00459,Q92569,P42336 482 2.14e-05 130 3 3 1.000 0.023 KEGG:04921 keg 1 Oxytocin signaling pathway 1 O00459,Q92569,P42336 482 2.19e-05 20 3 2 0.667 0.100 GO:0046834 BP 1 lipid phosphorylation 1 O00459,P42336 482 2.25e-05 239 3 3 1.000 0.013 GO:0046486 BP 1 glycerolipid metabolic process 1 O00459,Q92569,P42336 482 2.28e-05 240 3 3 1.000 0.013 GO:0006644 BP 1 phospholipid metabolic process 1 O00459,Q92569,P42336 482 2.33e-05 203 3 3 1.000 0.015 REAC:912526 rea 1 Interleukin receptor SHC signaling 1 O00459,Q92569,P42336 482 2.35e-05 134 3 3 1.000 0.022 KEGG:04150 keg 1 mTOR signaling pathway 1 O00459,Q92569,P42336 482 2.40e-05 135 3 3 1.000 0.022 KEGG:04022 keg 1 cGMP-PKG signaling pathway 1 O00459,Q92569,P42336 482 2.42e-05 21 3 2 0.667 0.095 GO:0043551 BP 1 regulation of phosphatidylinositol 3-kinase activity 1 O00459,Q92569 482 2.54e-05 209 3 3 1.000 0.014 REAC:451927 rea 1 Interleukin-2 signaling 1 O00459,Q92569,P42336 482 2.56e-05 21 3 2 0.667 0.095 REAC:2029485 rea 1 Role of phospholipids in phagocytosis 1 O00459,P42336 482 2.69e-05 213 3 3 1.000 0.014 REAC:76002 rea 1 Platelet activation, signaling and aggregation 1 O00459,Q92569,P42336 482 2.82e-05 22 3 2 0.667 0.091 REAC:373753 rea 1 Nephrin interactions 1 O00459,P42336 482 2.88e-05 218 3 3 1.000 0.014 REAC:512988 rea 1 Interleukin-3, 5 and GM-CSF signaling 1 O00459,Q92569,P42336 482 2.90e-05 260 3 3 1.000 0.012 GO:0071417 BP 1 cellular response to organonitrogen compound 1 O00459,Q92569,P42336 482 2.92e-05 23 3 2 0.667 0.087 GO:0046324 BP 1 regulation of glucose import 1 O00459,Q92569 482 3.05e-05 146 3 3 1.000 0.021 KEGG:04024 keg 1 cAMP signaling pathway 1 O00459,Q92569,P42336 482 3.24e-05 149 3 3 1.000 0.020 KEGG:04360 keg 1 Axon guidance 1 O00459,Q92569,P42336 482 3.65e-05 155 3 3 1.000 0.019 KEGG:04015 keg 1 Rap1 signaling pathway 1 O00459,Q92569,P42336 482 4.05e-05 27 3 2 0.667 0.074 GO:0043550 BP 1 regulation of lipid kinase activity 1 O00459,Q92569 482 4.17e-05 162 3 3 1.000 0.019 KEGG:05203 keg 1 Viral carcinogenesis 1 O00459,Q92569,P42336 482 4.49e-05 166 3 3 1.000 0.018 KEGG:04014 keg 1 Ras signaling pathway 1 O00459,Q92569,P42336 482 4.68e-05 29 3 2 0.667 0.069 GO:0046323 BP 1 glucose import 1 O00459,Q92569 482 4.78e-05 307 3 3 1.000 0.010 GO:0010243 BP 1 response to organonitrogen compound 1 O00459,Q92569,P42336 482 4.97e-05 311 3 3 1.000 0.010 GO:0032870 BP 1 cellular response to hormone stimulus 1 O00459,Q92569,P42336 482 5.01e-05 30 3 2 0.667 0.067 GO:1900076 BP 1 regulation of cellular response to insulin stimulus 1 O00459,Q92569 482 5.08e-05 173 3 3 1.000 0.017 KEGG:05205 keg 1 Proteoglycans in cancer 1 O00459,Q92569,P42336 482 5.17e-05 315 3 3 1.000 0.010 GO:1901699 BP 1 cellular response to nitrogen compound 1 O00459,Q92569,P42336 482 5.26e-05 175 3 3 1.000 0.017 KEGG:04810 keg 1 Regulation of actin cytoskeleton 1 O00459,Q92569,P42336 482 5.36e-05 31 3 2 0.667 0.065 GO:1903725 BP 1 regulation of phospholipid metabolic process 1 O00459,Q92569 482 5.55e-05 271 3 3 1.000 0.011 REAC:1433557 rea 1 Signaling by SCF-KIT 1 O00459,Q92569,P42336 482 5.61e-05 272 3 3 1.000 0.011 REAC:1236394 rea 1 Signaling by ERBB4 1 O00459,Q92569,P42336 482 5.64e-05 179 3 3 1.000 0.017 KEGG:04510 keg 1 Focal adhesion 1 O00459,Q92569,P42336 482 5.73e-05 180 3 3 1.000 0.017 KEGG:05169 keg 1 Epstein-Barr virus infection 1 O00459,Q92569,P42336 482 6.13e-05 280 3 3 1.000 0.011 REAC:5654716 rea 1 Downstream signaling of activated FGFR4 1 O00459,Q92569,P42336 482 6.13e-05 280 3 3 1.000 0.011 REAC:5654696 rea 1 Downstream signaling of activated FGFR2 1 O00459,Q92569,P42336 482 6.13e-05 280 3 3 1.000 0.011 REAC:5654708 rea 1 Downstream signaling of activated FGFR3 1 O00459,Q92569,P42336 482 6.16e-05 334 3 3 1.000 0.009 GO:0090407 BP 1 organophosphate biosynthetic process 1 O00459,Q92569,P42336 482 6.19e-05 281 3 3 1.000 0.011 REAC:5654687 rea 1 Downstream signaling of activated FGFR1 1 O00459,Q92569,P42336 482 6.33e-05 283 3 3 1.000 0.011 REAC:5654743 rea 1 Signaling by FGFR4 1 O00459,Q92569,P42336 482 6.33e-05 283 3 3 1.000 0.011 REAC:5654741 rea 1 Signaling by FGFR3 1 O00459,Q92569,P42336 482 6.46e-05 285 3 3 1.000 0.011 REAC:5654736 rea 1 Signaling by FGFR1 1 O00459,Q92569,P42336 482 6.60e-05 287 3 3 1.000 0.010 REAC:881907 rea 1 Gastrin-CREB signalling pathway via PKC and MAPK 1 O00459,Q92569,P42336 482 6.60e-05 287 3 3 1.000 0.010 REAC:449147 rea 1 Signaling by Interleukins 1 O00459,Q92569,P42336 482 6.81e-05 290 3 3 1.000 0.010 REAC:2424491 rea 1 DAP12 signaling 1 O00459,Q92569,P42336 482 6.95e-05 292 3 3 1.000 0.010 REAC:186763 rea 1 Downstream signal transduction 1 O00459,Q92569,P42336 482 7.10e-05 294 3 3 1.000 0.010 REAC:2172127 rea 1 DAP12 interactions 1 O00459,Q92569,P42336 482 7.21e-05 352 3 3 1.000 0.009 GO:0009725 BP 1 response to hormone 1 O00459,Q92569,P42336 482 7.85e-05 304 3 3 1.000 0.010 REAC:177929 rea 1 Signaling by EGFR 1 O00459,Q92569,P42336 482 7.93e-05 305 3 3 1.000 0.010 REAC:2454202 rea 1 Fc epsilon receptor (FCERI) signaling 1 O00459,Q92569,P42336 482 8.18e-05 367 3 3 1.000 0.008 GO:0008610 BP 1 lipid biosynthetic process 1 O00459,Q92569,P42336 482 8.24e-05 309 3 3 1.000 0.010 REAC:5654738 rea 1 Signaling by FGFR2 1 O00459,Q92569,P42336 482 8.24e-05 309 3 3 1.000 0.010 REAC:5663202 rea 1 Diseases of signal transduction 1 O00459,Q92569,P42336 482 8.40e-05 311 3 3 1.000 0.010 REAC:190236 rea 1 Signaling by FGFR 1 O00459,Q92569,P42336 482 8.49e-05 312 3 3 1.000 0.010 REAC:186797 rea 1 Signaling by PDGF 1 O00459,Q92569,P42336 482 8.54e-05 39 3 2 0.667 0.051 GO:0046934 MF 1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1 O00459,P42336 482 8.94e-05 378 3 3 1.000 0.008 GO:1901698 BP 1 response to nitrogen compound 1 O00459,Q92569,P42336 482 9.33e-05 322 3 3 1.000 0.009 REAC:187037 rea 1 NGF signalling via TRKA from the plasma membrane 1 O00459,Q92569,P42336 482 9.92e-05 42 3 2 0.667 0.048 GO:0052813 MF 1 phosphatidylinositol bisphosphate kinase activity 1 O00459,P42336 482 1.02e-04 218 3 3 1.000 0.014 KEGG:05166 keg 1 HTLV-I infection 1 O00459,Q92569,P42336 482 1.12e-04 342 3 3 1.000 0.009 REAC:388396 rea 1 GPCR downstream signaling 1 O00459,Q92569,P42336 482 1.34e-04 432 3 3 1.000 0.007 GO:0007169 BP 1 transmembrane receptor protein tyrosine kinase signaling pathway 1 O00459,Q92569,P42336 482 1.45e-04 444 3 3 1.000 0.007 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 O00459,Q92569,P42336 482 1.68e-04 257 3 3 1.000 0.012 KEGG:04151 keg 1 PI3K-Akt signaling pathway 1 O00459,Q92569,P42336 482 1.71e-04 394 3 3 1.000 0.008 REAC:166520 rea 1 Signalling by NGF 1 O00459,Q92569,P42336 482 1.90e-04 58 3 2 0.667 0.034 GO:0010827 BP 1 regulation of glucose transport 1 O00459,Q92569 482 2.45e-04 444 3 3 1.000 0.007 REAC:109582 rea 1 Hemostasis 1 O00459,Q92569,P42336 482 2.49e-04 446 3 3 1.000 0.007 REAC:1280215 rea 1 Cytokine Signaling in Immune system 1 O00459,Q92569,P42336 482 2.53e-04 65 3 2 0.667 0.031 REAC:109704 rea 1 PI3K Cascade 1 O00459,P42336 482 2.62e-04 68 3 2 0.667 0.029 GO:0038094 BP 1 Fc-gamma receptor signaling pathway 1 O00459,P42336 482 2.62e-04 68 3 2 0.667 0.029 GO:0038096 BP 1 Fc-gamma receptor signaling pathway involved in phagocytosis 1 O00459,P42336 482 2.62e-04 68 3 2 0.667 0.029 GO:0002433 BP 1 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 1 O00459,P42336 482 2.71e-04 459 3 3 1.000 0.007 REAC:422475 rea 1 Axon guidance 1 O00459,Q92569,P42336 482 2.78e-04 70 3 2 0.667 0.029 GO:0002431 BP 1 Fc receptor mediated stimulatory signaling pathway 1 O00459,P42336 482 2.86e-04 71 3 2 0.667 0.028 GO:0048010 BP 1 vascular endothelial growth factor receptor signaling pathway 1 O00459,P42336 482 2.93e-04 70 3 2 0.667 0.029 REAC:202733 rea 1 Cell surface interactions at the vascular wall 1 O00459,P42336 482 3.21e-04 578 3 3 1.000 0.005 GO:0016773 MF 1 phosphotransferase activity, alcohol group as acceptor 1 O00459,Q92569,P42336 482 3.34e-04 586 3 3 1.000 0.005 GO:1901700 BP 1 response to oxygen-containing compound 1 O00459,Q92569,P42336 482 3.40e-04 325 3 3 1.000 0.009 KEGG:05200 keg 1 Pathways in cancer 1 O00459,Q92569,P42336 482 3.45e-04 78 3 2 0.667 0.026 GO:0015758 BP 1 glucose transport 1 O00459,Q92569 482 3.45e-04 78 3 2 0.667 0.026 GO:0008645 BP 1 hexose transport 1 O00459,Q92569 482 3.46e-04 593 3 3 1.000 0.005 GO:0007167 BP 1 enzyme linked receptor protein signaling pathway 1 O00459,Q92569,P42336 482 3.54e-04 79 3 2 0.667 0.025 GO:0015749 BP 1 monosaccharide transport 1 O00459,Q92569 482 3.72e-04 81 3 2 0.667 0.025 GO:0014066 BP 1 regulation of phosphatidylinositol 3-kinase signaling 1 O00459,P42336 482 3.91e-04 83 3 2 0.667 0.024 GO:0008643 BP 1 carbohydrate transport 1 O00459,Q92569 482 3.93e-04 81 3 2 0.667 0.025 REAC:2029480 rea 1 Fcgamma receptor (FCGR) dependent phagocytosis 1 O00459,P42336 482 4.03e-04 624 3 3 1.000 0.005 GO:1990234 CC 1 transferase complex 1 O00459,Q92569,P42336 482 4.15e-04 630 3 3 1.000 0.005 GO:0016301 MF 1 kinase activity 1 O00459,Q92569,P42336 482 4.21e-04 633 3 3 1.000 0.005 GO:0044255 BP 1 cellular lipid metabolic process 1 O00459,Q92569,P42336 482 4.41e-04 643 3 3 1.000 0.005 GO:0071495 BP 1 cellular response to endogenous stimulus 1 O00459,Q92569,P42336 482 4.75e-04 89 3 2 0.667 0.022 REAC:202424 rea 1 Downstream TCR signaling 1 O00459,P42336 482 5.02e-04 94 3 2 0.667 0.021 GO:0014065 BP 1 phosphatidylinositol 3-kinase signaling 1 O00459,P42336 482 5.09e-04 674 3 3 1.000 0.004 GO:0019637 BP 1 organophosphate metabolic process 1 O00459,Q92569,P42336 482 5.30e-04 94 3 2 0.667 0.021 REAC:1500931 rea 1 Cell-Cell communication 1 O00459,P42336 482 5.39e-04 577 3 3 1.000 0.005 REAC:372790 rea 1 Signaling by GPCR 1 O00459,Q92569,P42336 482 6.00e-04 712 3 3 1.000 0.004 GO:0009719 BP 1 response to endogenous stimulus 1 O00459,Q92569,P42336 482 6.25e-04 606 3 3 1.000 0.005 REAC:556833 rea 1 Metabolism of lipids and lipoproteins 1 O00459,Q92569,P42336 482 6.50e-04 614 3 3 1.000 0.005 REAC:1280218 rea 1 Adaptive Immune System 1 O00459,Q92569,P42336 482 6.74e-04 106 3 2 0.667 0.019 REAC:202403 rea 1 TCR signaling 1 O00459,P42336 482 7.13e-04 112 3 2 0.667 0.018 GO:0038095 BP 1 Fc-epsilon receptor signaling pathway 1 O00459,P42336 482 7.15e-04 755 3 3 1.000 0.004 GO:0016772 MF 1 transferase activity, transferring phosphorus-containing groups 1 O00459,Q92569,P42336 482 7.44e-04 765 3 3 1.000 0.004 GO:0006629 BP 1 lipid metabolic process 1 O00459,Q92569,P42336 482 7.92e-04 118 3 2 0.667 0.017 GO:0048015 BP 1 phosphatidylinositol-mediated signaling 1 O00459,P42336 482 8.05e-04 119 3 2 0.667 0.017 GO:0048017 BP 1 inositol lipid-mediated signaling 1 O00459,P42336 482 8.32e-04 121 3 2 0.667 0.017 GO:0030258 BP 1 lipid modification 1 O00459,P42336 482 8.74e-04 124 3 2 0.667 0.016 GO:0019207 MF 1 kinase regulator activity 1 O00459,Q92569 482 8.74e-04 124 3 2 0.667 0.016 GO:0050852 BP 1 T cell receptor signaling pathway 1 O00459,P42336 482 1.02e-03 851 3 3 1.000 0.004 GO:0044711 BP 1 single-organism biosynthetic process 1 O00459,Q92569,P42336 482 1.04e-03 718 3 3 1.000 0.004 REAC:1266738 rea 1 Developmental Biology 1 O00459,Q92569,P42336 482 1.04e-03 1291 3 3 1.000 0.002 TF:M00071_0 tf 1 Factor: E47; motif: NNNMRCAGGTGTTMNN; match class: 0 1 O00459,Q92569,P42336 482 1.05e-03 720 3 3 1.000 0.004 REAC:1643685 rea 1 Disease 1 O00459,Q92569,P42336 482 1.15e-03 142 3 2 0.667 0.014 GO:0006909 BP 1 phagocytosis 1 O00459,P42336 482 1.16e-03 143 3 2 0.667 0.014 GO:0050851 BP 1 antigen receptor-mediated signaling pathway 1 O00459,P42336 482 1.23e-03 147 3 2 0.667 0.014 GO:0019216 BP 1 regulation of lipid metabolic process 1 O00459,Q92569 482 1.33e-03 2 3 1 0.333 0.500 GO:0005943 CC 1 phosphatidylinositol 3-kinase complex, class IA 1 P42336 482 1.55e-03 165 3 2 0.667 0.012 GO:0038093 BP 1 Fc receptor signaling pathway 1 O00459,P42336 482 1.57e-03 166 3 2 0.667 0.012 GO:0050900 BP 1 leukocyte migration 1 O00459,P42336 482 1.74e-03 1 3 1 0.333 1.000 OMIM:182000 omi 1 KERATOSIS, SEBORRHEIC 1 P42336 482 1.74e-03 1 3 1 0.333 1.000 OMIM:615108 omi 1 COWDEN SYNDROME 5; CWS5 1 P42336 482 1.74e-03 1 3 1 0.333 1.000 OMIM:602501 omi 1 MEGALENCEPHALY-CAPILLARY MALFORMATION-POLYMICROGYRIA SYNDROME; MCAP;;MACROCEPHALY-CAPILLARY MALFORMATION; MCM;;MEGALENCEPHALY-CAPILLARY MALFORMATION SYNDROME;;MACROCEPHALY-CUTIS MARMORATA TELANGIECTATICA CONGENITA; MCMTC;;MEGALENCEPHALY-CUTIS MARMORATA TELANGIECTATICA CONGENITA 1 P42336 482 1.74e-03 1 3 1 0.333 1.000 OMIM:603387 omi 1 MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 1;MPPH1;;MEGALENCEPHALY, POLYMICROGYRIA, MEGA CORPUS CALLOSUM SYNDROME; MPPH;;MEG-PMG-MEGACC SYNDROME;;MEGALENCEPHALY, MEGA CORPUS CALLOSUM, AND COMPLETE LACK OF MOTOR DEVELOPMENT 1 O00459 482 1.74e-03 1 3 1 0.333 1.000 OMIM:612918 omi 1 CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, AND EPIDERMALNEVI;;CLOVE SYNDROME;;CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, EPIDERMALNEVI, AND SKELETAL/SPINAL ABNORMALITIES;;CLOVES SYNDROME 1 P42336 482 1.83e-03 1033 3 3 1.000 0.003 GO:1902494 CC 1 catalytic complex 1 O00459,Q92569,P42336 482 2.00e-03 3 3 1 0.333 0.333 GO:0038028 BP 1 insulin receptor signaling pathway via phosphatidylinositol 3-kinase 1 P42336 482 2.00e-03 3 3 1 0.333 0.333 GO:0097651 CC 1 phosphatidylinositol 3-kinase complex, class I 1 P42336 482 2.13e-03 1086 3 3 1.000 0.003 GO:0048584 BP 1 positive regulation of response to stimulus 1 O00459,Q92569,P42336 482 2.32e-03 938 3 3 1.000 0.003 REAC:168249 rea 1 Innate Immune System 1 O00459,Q92569,P42336 482 2.44e-03 323 3 2 0.667 0.006 MI:hsa-miR-143* mi 1 MI:hsa-miR-143* 1 O00459,P42336 482 2.58e-03 1157 3 3 1.000 0.003 GO:0071310 BP 1 cellular response to organic substance 1 O00459,Q92569,P42336 482 2.65e-03 216 3 2 0.667 0.009 GO:0002429 BP 1 immune response-activating cell surface receptor signaling pathway 1 O00459,P42336 482 2.86e-03 139 3 2 0.667 0.014 KEGG:05206 keg 1 MicroRNAs in cancer 1 O00459,P42336 482 3.13e-03 235 3 2 0.667 0.009 GO:0002768 BP 1 immune response-regulating cell surface receptor signaling pathway 1 O00459,P42336 482 3.38e-03 1266 3 3 1.000 0.002 GO:0016310 BP 1 phosphorylation 1 O00459,Q92569,P42336 482 3.43e-03 240 3 2 0.667 0.008 REAC:112399 rea 1 IRS-mediated signalling 1 O00459,P42336 482 3.46e-03 241 3 2 0.667 0.008 REAC:2428924 rea 1 IGF1R signaling cascade 1 O00459,P42336 482 3.46e-03 241 3 2 0.667 0.008 REAC:2428928 rea 1 IRS-related events triggered by IGF1R 1 O00459,P42336 482 3.49e-03 242 3 2 0.667 0.008 REAC:74751 rea 1 Insulin receptor signalling cascade 1 O00459,P42336 482 3.49e-03 242 3 2 0.667 0.008 REAC:2404192 rea 1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1 O00459,P42336 482 3.77e-03 16 3 1 0.333 0.062 TF:M06012_0 tf 1 Factor: ZNF586; motif: ATGGCGTGMTG; match class: 0 1 Q92569 482 4.11e-03 263 3 2 0.667 0.008 REAC:74752 rea 1 Signaling by Insulin receptor 1 O00459,P42336 482 4.39e-03 272 3 2 0.667 0.007 REAC:4420097 rea 1 VEGFA-VEGFR2 Pathway 1 O00459,P42336 482 4.41e-03 10 3 1 0.333 0.100 REAC:8853334 rea 1 Signaling by FGFR3 fusions in cancer 1 P42336 482 4.51e-03 1394 3 3 1.000 0.002 GO:0010033 BP 1 response to organic substance 1 O00459,Q92569,P42336 482 4.59e-03 278 3 2 0.667 0.007 REAC:194138 rea 1 Signaling by VEGF 1 O00459,P42336 482 4.66e-03 7 3 1 0.333 0.143 GO:0035005 MF 1 1-phosphatidylinositol-4-phosphate 3-kinase activity 1 P42336 482 4.73e-03 1416 3 3 1.000 0.002 GO:0007166 BP 1 cell surface receptor signaling pathway 1 O00459,Q92569,P42336 482 4.80e-03 1423 3 3 1.000 0.002 GO:0070887 BP 1 cellular response to chemical stimulus 1 O00459,Q92569,P42336 482 4.85e-03 11 3 1 0.333 0.091 REAC:5655291 rea 1 Signaling by FGFR4 in disease 1 P42336 482 5.19e-03 303 3 2 0.667 0.007 GO:0002757 BP 1 immune response-activating signal transduction 1 O00459,P42336 482 5.29e-03 12 3 1 0.333 0.083 REAC:1963642 rea 1 PI3K events in ERBB2 signaling 1 P42336 482 5.60e-03 1498 3 3 1.000 0.002 GO:0044765 BP 1 single-organism transport 1 O00459,Q92569,P42336 482 5.68e-03 317 3 2 0.667 0.006 GO:0002252 BP 1 immune effector process 1 O00459,P42336 482 5.86e-03 322 3 2 0.667 0.006 GO:0002764 BP 1 immune response-regulating signaling pathway 1 O00459,P42336 482 6.10e-03 2326 3 3 1.000 0.001 TF:M04169_0 tf 1 Factor: FIGLA; motif: NMCACCTGKN; match class: 0 1 O00459,Q92569,P42336 482 6.17e-03 14 3 1 0.333 0.071 REAC:8853338 rea 1 Signaling by FGFR3 point mutants in cancer 1 P42336 482 6.17e-03 14 3 1 0.333 0.071 REAC:5637810 rea 1 Constitutive Signaling by EGFRvIII 1 P42336 482 6.17e-03 14 3 1 0.333 0.071 REAC:5655332 rea 1 Signaling by FGFR3 in disease 1 P42336 482 6.17e-03 14 3 1 0.333 0.071 REAC:5637812 rea 1 Signaling by EGFRvIII in Cancer 1 P42336 482 6.41e-03 337 3 2 0.667 0.006 GO:0002253 BP 1 activation of immune response 1 O00459,P42336 482 6.96e-03 4 3 1 0.333 0.250 OMIM:162900 omi 1 NEVUS, EPIDERMAL;;NEVUS, KERATINOCYTIC, NONEPIDERMOLYTICNEVUS SEBACEOUS, INCLUDED;;NEVUS, WOOLLY HAIR, INCLUDED 1 P42336 482 7.00e-03 2436 3 3 1.000 0.001 TF:M01001_0 tf 1 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN; match class: 0 1 O00459,Q92569,P42336 482 7.07e-03 354 3 2 0.667 0.006 GO:0006897 BP 1 endocytosis 1 O00459,P42336 482 7.49e-03 17 3 1 0.333 0.059 REAC:1236382 rea 1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1 P42336 482 7.49e-03 17 3 1 0.333 0.059 REAC:1643713 rea 1 Signaling by EGFR in Cancer 1 P42336 482 7.49e-03 17 3 1 0.333 0.059 REAC:5637815 rea 1 Signaling by Ligand-Responsive EGFR Variants in Cancer 1 P42336 482 7.51e-03 1652 3 3 1.000 0.002 GO:1902578 BP 1 single-organism localization 1 O00459,Q92569,P42336 482 7.76e-03 33 3 1 0.333 0.030 TF:M03940_0 tf 1 Factor: ZNF75A; motif: GCTTTTCCCACA; match class: 0 1 Q92569 482 7.93e-03 18 3 1 0.333 0.056 REAC:1839117 rea 1 Signaling by cytosolic FGFR1 fusion mutants 1 P42336 482 8.40e-03 1715 3 3 1.000 0.002 GO:0016740 MF 1 transferase activity 1 O00459,Q92569,P42336 482 8.43e-03 387 3 2 0.667 0.005 GO:0050778 BP 1 positive regulation of immune response 1 O00459,P42336 482 8.65e-03 13 3 1 0.333 0.077 GO:2000811 BP 1 negative regulation of anoikis 1 P42336 482 8.70e-03 5 3 1 0.333 0.200 OMIM:613659 omi 1 GASTRIC CANCERGASTRIC CANCER, INTESTINAL, INCLUDED 1 P42336 482 8.71e-03 1457 3 3 1.000 0.002 REAC:168256 rea 1 Immune System 1 O00459,Q92569,P42336 482 8.96e-03 2644 3 3 1.000 0.001 TF:M00808_0 tf 1 Factor: Pax; motif: CTGGAACTMAC; match class: 0 1 O00459,Q92569,P42336 482 9.31e-03 14 3 1 0.333 0.071 GO:0016307 MF 1 phosphatidylinositol phosphate kinase activity 1 P42336 482 1.04e-02 6 3 1 0.333 0.167 OMIM:167000 omi 1 OVARIAN CANCEROVARIAN CANCER, EPITHELIAL, INCLUDED 1 P42336 482 1.06e-02 1851 3 3 1.000 0.002 GO:0006796 BP 1 phosphate-containing compound metabolic process 1 O00459,Q92569,P42336 482 1.08e-02 439 3 2 0.667 0.005 GO:0043549 BP 1 regulation of kinase activity 1 O00459,Q92569 482 1.10e-02 1575 3 3 1.000 0.002 REAC:162582 rea 1 Signal Transduction 1 O00459,Q92569,P42336 482 1.10e-02 25 3 1 0.333 0.040 REAC:1839124 rea 1 FGFR1 mutant receptor activation 1 P42336 482 1.11e-02 1882 3 3 1.000 0.002 GO:0042221 BP 1 response to chemical 1 O00459,Q92569,P42336 482 1.13e-02 48 3 1 0.333 0.021 TF:M06545_0 tf 1 Factor: ZNF485; motif: NGGGAKGGGGGW; match class: 0 1 Q92569 482 1.18e-02 1923 3 3 1.000 0.002 GO:0006793 BP 1 phosphorus metabolic process 1 O00459,Q92569,P42336 482 1.20e-02 18 3 1 0.333 0.056 GO:2000209 BP 1 regulation of anoikis 1 P42336 482 1.31e-02 483 3 2 0.667 0.004 GO:0051050 BP 1 positive regulation of transport 1 O00459,Q92569 482 1.31e-02 3005 3 3 1.000 0.001 TF:M04177_0 tf 1 Factor: MESP1; motif: NRCACCTGNN; match class: 0 1 O00459,Q92569,P42336 482 1.33e-02 20 3 1 0.333 0.050 GO:0043276 BP 1 anoikis 1 P42336 482 1.36e-02 879 3 2 0.667 0.002 TF:M02066_1 tf 1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 1 O00459,P42336 482 1.39e-02 8 3 1 0.333 0.125 OMIM:114550 omi 1 HEPATOCELLULAR CARCINOMA;;HCC;;CANCER, HEPATOCELLULAR;;LIVER CANCER;;LIVER CELL CARCINOMA; LCC;;HEPATOMAHEPATOBLASTOMA, INCLUDED;;HEPATOBLASTOMA CAUSED BY SOMATIC MUTATION, INCLUDED 1 P42336 482 1.39e-02 499 3 2 0.667 0.004 GO:0002684 BP 1 positive regulation of immune system process 1 O00459,P42336 482 1.40e-02 501 3 2 0.667 0.004 GO:0050776 BP 1 regulation of immune response 1 O00459,P42336 482 1.41e-02 32 3 1 0.333 0.031 REAC:5655302 rea 1 Signaling by FGFR1 in disease 1 P42336 482 1.43e-02 1718 3 3 1.000 0.002 REAC:1430728 rea 1 Metabolism 1 O00459,Q92569,P42336 482 1.49e-02 34 3 1 0.333 0.029 REAC:5655253 rea 1 Signaling by FGFR2 in disease 1 P42336 482 1.55e-02 2101 3 3 1.000 0.001 GO:0048583 BP 1 regulation of response to stimulus 1 O00459,Q92569,P42336 482 1.55e-02 940 3 2 0.667 0.002 TF:M06080_0 tf 1 Factor: ZNF99; motif: KGGKGTGAGA; match class: 0 1 O00459,P42336 482 1.59e-02 68 3 1 0.333 0.015 TF:M06579_0 tf 1 Factor: ZNF354B; motif: NGKGGAATAAKM; match class: 0 1 O00459 482 1.60e-02 954 3 2 0.667 0.002 TF:M02378_0 tf 1 Factor: HIF1A:ARNT; motif: VNACGTGN; match class: 0 1 O00459,P42336 482 1.78e-02 1007 3 2 0.667 0.002 TF:M03974_0 tf 1 Factor: ERF; motif: ACCGGAAGTR; match class: 0 1 O00459,P42336 482 1.85e-02 577 3 2 0.667 0.003 GO:0051338 BP 1 regulation of transferase activity 1 O00459,Q92569 482 1.86e-02 28 3 1 0.333 0.036 GO:0042993 BP 1 positive regulation of transcription factor import into nucleus 1 O00459 482 1.89e-02 582 3 2 0.667 0.003 GO:0030234 MF 1 enzyme regulator activity 1 O00459,Q92569 482 1.89e-02 43 3 1 0.333 0.023 REAC:1227986 rea 1 Signaling by ERBB2 1 P42336 482 1.92e-02 82 3 1 0.333 0.012 TF:M07410_1 tf 1 Factor: RFX2; motif: GTYNCCATGGCAACNGNNN; match class: 1 1 O00459 482 2.01e-02 86 3 1 0.333 0.012 TF:M07215_1 tf 1 Factor: HNF4A; motif: NTGRACTTTGNNCYN; match class: 1 1 O00459 482 2.04e-02 87 3 1 0.333 0.011 TF:M02106_1 tf 1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 1 Q92569 482 2.06e-02 31 3 1 0.333 0.032 GO:0038128 BP 1 ERBB2 signaling pathway 1 P42336 482 2.16e-02 945 3 2 0.667 0.002 HPA:004030_03 hpa 1 breast; myoepithelial cells[Uncertain,High] 1 Q92569,P42336 482 2.20e-02 94 3 1 0.333 0.011 TF:M03972_1 tf 1 Factor: ELK3; motif: ACCGGAAGTN; match class: 1 1 O00459 482 2.26e-02 13 3 1 0.333 0.077 OMIM:211980 omi 1 LUNG CANCERALVEOLAR CELL CARCINOMA, INCLUDED;;ADENOCARCINOMA OF LUNG, INCLUDED;;NONSMALL CELL LUNG CANCER, INCLUDED;;LUNG CANCER, PROTECTION AGAINST, INCLUDED 1 P42336 482 2.27e-02 640 3 2 0.667 0.003 GO:0016477 BP 1 cell migration 1 O00459,P42336 482 2.32e-02 3632 3 3 1.000 0.001 TF:M02012_1 tf 1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 1 O00459,Q92569,P42336 482 2.34e-02 2412 3 3 1.000 0.001 GO:0044425 CC 1 membrane part 1 O00459,Q92569,P42336 482 2.37e-02 54 3 1 0.333 0.019 REAC:1226099 rea 1 Signaling by FGFR in disease 1 P42336 482 2.39e-02 36 3 1 0.333 0.028 GO:1990782 MF 1 protein tyrosine kinase binding 1 O00459 482 2.39e-02 36 3 1 0.333 0.028 GO:0030971 MF 1 receptor tyrosine kinase binding 1 O00459 482 2.41e-02 103 3 1 0.333 0.010 TF:M00648_0 tf 1 Factor: MAF; motif: TRGRRGGAAGTKKSST; match class: 0 1 O00459 482 2.48e-02 1196 3 2 0.667 0.002 TF:M03846_1 tf 1 Factor: SMAD5; motif: GSGGCAGM; match class: 1 1 O00459,P42336 482 2.50e-02 107 3 1 0.333 0.009 TF:M03946_0 tf 1 Factor: GRHL1; motif: AACCGGTNNAACCGGTT; match class: 0 1 O00459 482 2.57e-02 110 3 1 0.333 0.009 TF:M04097_1 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 1 1 O00459 482 2.59e-02 39 3 1 0.333 0.026 GO:0031294 BP 1 lymphocyte costimulation 1 P42336 482 2.59e-02 39 3 1 0.333 0.026 GO:0031295 BP 1 T cell costimulation 1 P42336 482 2.64e-02 690 3 2 0.667 0.003 GO:0002682 BP 1 regulation of immune system process 1 O00459,P42336 482 2.69e-02 115 3 1 0.333 0.009 TF:M03987_1 tf 1 Factor: FEV; motif: ACCGGAAGTN; match class: 1 1 O00459 482 2.73e-02 117 3 1 0.333 0.009 TF:M06285_0 tf 1 Factor: ZNF124; motif: NGGTACTTGGGA; match class: 0 1 Q92569 482 2.79e-02 711 3 2 0.667 0.003 GO:0051674 BP 1 localization of cell 1 O00459,P42336 482 2.79e-02 711 3 2 0.667 0.003 GO:0048870 BP 1 cell motility 1 O00459,P42336 482 2.80e-02 2560 3 3 1.000 0.001 GO:0044710 BP 1 single-organism metabolic process 1 O00459,Q92569,P42336 482 2.85e-02 43 3 1 0.333 0.023 GO:0001678 BP 1 cellular glucose homeostasis 1 O00459 482 2.87e-02 123 3 1 0.333 0.008 TF:M06092_0 tf 1 Factor: ZNF28; motif: NGGGAATWCCRW; match class: 0 1 O00459 482 2.89e-02 124 3 1 0.333 0.008 TF:M06124_0 tf 1 Factor: ZNF806; motif: GGTWRAAACSM; match class: 0 1 Q92569 482 2.94e-02 126 3 1 0.333 0.008 TF:M00478_1 tf 1 Factor: Cdc5; motif: GATTTAACATAA; match class: 1 1 Q92569 482 3.01e-02 739 3 2 0.667 0.003 GO:0006955 BP 1 immune response 1 O00459,P42336 482 3.08e-02 2644 3 3 1.000 0.001 GO:0006810 BP 1 transport 1 O00459,Q92569,P42336 482 3.11e-02 1345 3 2 0.667 0.001 TF:M02064_0 tf 1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 0 1 O00459,P42336 482 3.17e-02 136 3 1 0.333 0.007 TF:M01002_1 tf 1 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN; match class: 1 1 O00459 482 3.17e-02 136 3 1 0.333 0.007 TF:M06262_0 tf 1 Factor: ZNF415; motif: NGGGGAAWCAGA; match class: 0 1 O00459 482 3.18e-02 760 3 2 0.667 0.003 GO:0042325 BP 1 regulation of phosphorylation 1 O00459,Q92569 482 3.24e-02 139 3 1 0.333 0.007 TF:M06915_0 tf 1 Factor: ZNF236; motif: NGWTTGTGCGNA; match class: 0 1 P42336 482 3.31e-02 2707 3 3 1.000 0.001 GO:0005829 CC 1 cytosol 1 O00459,Q92569,P42336 482 3.36e-02 4107 3 3 1.000 0.001 TF:M00729_0 tf 1 Factor: Cdx-2; motif: ANANTTTTATKRCC; match class: 0 1 O00459,Q92569,P42336 482 3.38e-02 51 3 1 0.333 0.020 GO:0042307 BP 1 positive regulation of protein import into nucleus 1 O00459 482 3.45e-02 52 3 1 0.333 0.019 GO:1904591 BP 1 positive regulation of protein import 1 O00459 482 3.45e-02 52 3 1 0.333 0.019 GO:0042990 BP 1 regulation of transcription factor import into nucleus 1 O00459 482 3.46e-02 2748 3 3 1.000 0.001 GO:0051234 BP 1 establishment of localization 1 O00459,Q92569,P42336 482 3.51e-02 2761 3 3 1.000 0.001 GO:0048522 BP 1 positive regulation of cellular process 1 O00459,Q92569,P42336 482 3.63e-02 21 3 1 0.333 0.048 OMIM:114480 omi 1 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED 1 P42336 482 3.64e-02 814 3 2 0.667 0.002 GO:0040011 BP 1 locomotion 1 O00459,P42336 482 3.64e-02 55 3 1 0.333 0.018 GO:0042991 BP 1 transcription factor import into nucleus 1 O00459 482 3.75e-02 161 3 1 0.333 0.006 TF:M07361_1 tf 1 Factor: MZF-1; motif: GKGGGGARNR; match class: 1 1 O00459 482 3.76e-02 828 3 2 0.667 0.002 GO:0098772 MF 1 molecular function regulator 1 O00459,Q92569 482 3.78e-02 57 3 1 0.333 0.018 GO:0060048 BP 1 cardiac muscle contraction 1 P42336 482 3.79e-02 163 3 1 0.333 0.006 TF:M05697_0 tf 1 Factor: ZNF235; motif: NCCGCWAAAYGC; match class: 0 1 O00459 482 3.88e-02 4310 3 3 1.000 0.001 TF:M03876_1 tf 1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 1 O00459,Q92569,P42336 482 4.18e-02 180 3 1 0.333 0.006 TF:M04097_0 tf 1 Factor: RFX3; motif: NGTTRCCATGGYAACN; match class: 0 1 O00459 482 4.23e-02 182 3 1 0.333 0.005 TF:M06151_0 tf 1 Factor: ZNF84; motif: NCCTMCGGMAGA; match class: 0 1 P42336 482 4.27e-02 184 3 1 0.333 0.005 TF:M05417_0 tf 1 Factor: ZNF641; motif: NAGGGGKGGGGN; match class: 0 1 P42336 482 4.29e-02 885 3 2 0.667 0.002 GO:0019220 BP 1 regulation of phosphate metabolic process 1 O00459,Q92569 482 4.30e-02 65 3 1 0.333 0.015 GO:0046824 BP 1 positive regulation of nucleocytoplasmic transport 1 O00459 482 4.40e-02 897 3 2 0.667 0.002 GO:0051174 BP 1 regulation of phosphorus metabolic process 1 O00459,Q92569 482 4.50e-02 194 3 1 0.333 0.005 TF:M00957_0 tf 1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 0 1 O00459 482 4.52e-02 3004 3 3 1.000 0.001 GO:0007165 BP 1 signal transduction 1 O00459,Q92569,P42336 482 4.64e-02 200 3 1 0.333 0.005 TF:M01752_1 tf 1 Factor: ERG; motif: ACCGGAART; match class: 1 1 O00459 482 4.65e-02 3033 3 3 1.000 0.001 GO:0048518 BP 1 positive regulation of biological process 1 O00459,Q92569,P42336 482 4.66e-02 1408 3 2 0.667 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 Q92569,P42336 482 4.70e-02 71 3 1 0.333 0.014 GO:0019903 MF 1 protein phosphatase binding 1 O00459 482 4.72e-02 1672 3 2 0.667 0.001 TF:M04029_0 tf 1 Factor: MEIS2; motif: TTGACAGS; match class: 0 1 Q92569,P42336 482 4.76e-02 72 3 1 0.333 0.014 GO:1900182 BP 1 positive regulation of protein localization to nucleus 1 O00459 482 4.78e-02 936 3 2 0.667 0.002 GO:0051049 BP 1 regulation of transport 1 O00459,Q92569 482 4.89e-02 211 3 1 0.333 0.005 TF:M05845_0 tf 1 Factor: ZNF690; motif: GGGGGACGGN; match class: 0 1 Q92569 482 4.94e-02 213 3 1 0.333 0.005 TF:M02069_1 tf 1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 1 O00459 482 4.96e-02 75 3 1 0.333 0.013 GO:0006941 BP 1 striated muscle contraction 1 P42336 482 5.00e-02 29 3 1 0.333 0.034 OMIM:114500 omi 1 Colorectal Cancer 1 P42336 482 5.00e-02 958 3 2 0.667 0.002 GO:0016192 BP 1 vesicle-mediated transport 1 O00459,P42336 482 5.00e-02 66 3 1 0.333 0.015 KEGG:00562 keg 1 Inositol phosphate metabolism 1 P42336 482 5.00e-02 12 3 2 0.667 0.167 HP:0001355 hp 1 Megalencephaly 1 O00459,P42336 482 5.00e-02 115 3 1 0.333 0.009 REAC:194840 rea 1 Rho GTPase cycle 1 O00459 482 5.00e-02 2 3 1 0.333 0.500 CORUM:3133 cor 1 Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) 1 P42336 483 4.17e-03 2 2 1 0.500 0.500 GO:0032487 BP 1 regulation of Rap protein signal transduction 1 P35241 483 6.26e-03 3 2 1 0.500 0.333 GO:0045792 BP 1 negative regulation of cell size 1 P35241 483 8.34e-03 4 2 1 0.500 0.250 GO:1905666 BP 1 regulation of protein localization to endosome 1 P35241 483 8.34e-03 4 2 1 0.500 0.250 GO:1905668 BP 1 positive regulation of protein localization to endosome 1 P35241 483 8.34e-03 4 2 1 0.500 0.250 GO:1902965 BP 1 regulation of protein localization to early endosome 1 P35241 483 8.34e-03 4 2 1 0.500 0.250 GO:1902966 BP 1 positive regulation of protein localization to early endosome 1 P35241 483 1.04e-02 5 2 1 0.500 0.200 GO:1902946 BP 1 protein localization to early endosome 1 P35241 483 1.46e-02 7 2 1 0.500 0.143 GO:0034111 BP 1 negative regulation of homotypic cell-cell adhesion 1 P35241 483 1.67e-02 8 2 1 0.500 0.125 GO:0097066 BP 1 response to thyroid hormone 1 P35241 483 1.67e-02 8 2 1 0.500 0.125 GO:2000643 BP 1 positive regulation of early endosome to late endosome transport 1 P35241 483 1.67e-02 8 2 1 0.500 0.125 GO:0097067 BP 1 cellular response to thyroid hormone stimulus 1 P35241 483 2.08e-02 10 2 1 0.500 0.100 GO:1903651 BP 1 positive regulation of cytoplasmic transport 1 P35241 483 2.29e-02 11 2 1 0.500 0.091 GO:0032486 BP 1 Rap protein signal transduction 1 P35241 483 2.50e-02 12 2 1 0.500 0.083 GO:1900087 BP 1 positive regulation of G1/S transition of mitotic cell cycle 1 P35241 483 2.50e-02 12 2 1 0.500 0.083 GO:1900027 BP 1 regulation of ruffle assembly 1 P35241 483 2.50e-02 12 2 1 0.500 0.083 GO:0036010 BP 1 protein localization to endosome 1 P35241 483 2.92e-02 14 2 1 0.500 0.071 GO:1903392 BP 1 negative regulation of adherens junction organization 1 P35241 483 3.10e-02 42 2 1 0.500 0.024 HP:0000399 hp 1 Prelingual sensorineural hearing impairment 1 P35241 483 3.10e-02 42 2 1 0.500 0.024 HP:0012714 hp 1 Severe hearing impairment 1 P35241 483 3.10e-02 42 2 1 0.500 0.024 HP:0008625 hp 1 Severe sensorineural hearing impairment 1 P35241 483 3.10e-02 42 2 1 0.500 0.024 HP:0004463 hp 1 Absent brainstem auditory responses 1 P35241 483 3.13e-02 15 2 1 0.500 0.067 GO:0034260 BP 1 negative regulation of GTPase activity 1 P35241 483 3.13e-02 15 2 1 0.500 0.067 GO:0034110 BP 1 regulation of homotypic cell-cell adhesion 1 P35241 483 3.13e-02 15 2 1 0.500 0.067 GO:1902808 BP 1 positive regulation of cell cycle G1/S phase transition 1 P35241 483 3.13e-02 15 2 1 0.500 0.067 GO:0097178 BP 1 ruffle assembly 1 P35241 483 3.18e-02 43 2 1 0.500 0.023 HP:0011476 hp 1 Profound sensorineural hearing impairment 1 P35241 483 3.18e-02 43 2 1 0.500 0.023 HP:0012715 hp 1 Profound hearing impairment 1 P35241 483 3.18e-02 43 2 1 0.500 0.023 HP:0008568 hp 1 Vestibular areflexia 1 P35241 483 3.18e-02 43 2 1 0.500 0.023 HP:0011387 hp 1 Enlarged vestibular aqueduct 1 P35241 483 3.25e-02 44 2 1 0.500 0.023 HP:0007670 hp 1 Abnormal vestibulo-ocular reflex 1 P35241 483 3.25e-02 44 2 1 0.500 0.023 HP:0011376 hp 1 Morphological abnormality of the vestibule of the inner ear 1 P35241 483 3.32e-02 45 2 1 0.500 0.022 HP:0001756 hp 1 Vestibular hypofunction 1 P35241 483 3.33e-02 16 2 1 0.500 0.062 GO:0010737 BP 1 protein kinase A signaling 1 P35241 483 3.47e-02 47 2 1 0.500 0.021 HP:0007642 hp 1 Congenital stationary night blindness 1 P35241 483 3.54e-02 17 2 1 0.500 0.059 GO:2000641 BP 1 regulation of early endosome to late endosome transport 1 P35241 483 3.69e-02 50 2 1 0.500 0.020 HP:0011373 hp 1 Incomplete partition of the cochlea 1 P35241 483 3.69e-02 50 2 1 0.500 0.020 HP:0000376 hp 1 Incomplete partition of the cochlea type II 1 P35241 483 3.83e-02 52 2 1 0.500 0.019 HP:0008554 hp 1 Cochlear malformation 1 P35241 483 4.17e-02 20 2 1 0.500 0.050 GO:1903649 BP 1 regulation of cytoplasmic transport 1 P35241 483 4.42e-02 60 2 1 0.500 0.017 HP:0010984 hp 1 Digenic inheritance 1 P35241 483 4.71e-02 64 2 1 0.500 0.016 HP:0003680 hp 1 Nonprogressive 1 P35241 483 4.78e-02 65 2 1 0.500 0.015 HP:0040121 hp 1 Abnormality of the acoustic reflex 1 P35241 483 4.78e-02 65 2 1 0.500 0.015 HP:0008529 hp 1 Absence of acoustic reflex 1 P35241 483 4.85e-02 66 2 1 0.500 0.015 HP:0011474 hp 1 Childhood onset sensorineural hearing impairment 1 P35241 483 4.85e-02 66 2 1 0.500 0.015 HP:0004454 hp 1 Abnormal middle ear reflexes 1 P35241 483 5.00e-02 5 2 1 0.500 0.200 TF:M04572_0 tf 1 Factor: CREB3L1; motif: NTGCCACGTCAYCA; match class: 0 1 Q9H0I9 483 5.00e-02 28 2 1 0.500 0.036 REAC:437239 rea 1 Recycling pathway of L1 1 P35241 483 5.00e-02 1 2 1 0.500 1.000 OMIM:611022 omi 1 DEAFNESS, AUTOSOMAL RECESSIVE 24; DFNB24 1 P35241 483 5.00e-02 24 2 1 0.500 0.042 GO:0031529 BP 1 ruffle organization 1 P35241 483 5.00e-02 26 2 1 0.500 0.038 KEGG:00030 keg 1 Pentose phosphate pathway 1 Q9H0I9 484 1.22e-07 2 3 2 0.667 1.000 GO:0016094 BP 1 polyprenol biosynthetic process 1 Q86SQ9,Q96E22 484 1.22e-06 5 3 2 0.667 0.400 GO:0006489 BP 1 dolichyl diphosphate biosynthetic process 1 Q86SQ9,Q96E22 484 1.22e-06 5 3 2 0.667 0.400 GO:0046465 BP 1 dolichyl diphosphate metabolic process 1 Q86SQ9,Q96E22 484 1.82e-06 6 3 2 0.667 0.333 GO:0016093 BP 1 polyprenol metabolic process 1 Q86SQ9,Q96E22 484 2.11e-06 5 3 2 0.667 0.400 REAC:446199 rea 1 Synthesis of Dolichyl-phosphate 1 Q86SQ9,Q96E22 484 9.47e-06 13 3 2 0.667 0.154 GO:0008299 BP 1 isoprenoid biosynthetic process 1 Q86SQ9,Q96E22 484 9.47e-06 13 3 2 0.667 0.154 GO:0004659 MF 1 prenyltransferase activity 1 Q86SQ9,Q96E22 484 1.28e-05 15 3 2 0.667 0.133 GO:0006490 BP 1 oligosaccharide-lipid intermediate biosynthetic process 1 Q86SQ9,Q96E22 484 1.28e-05 15 3 2 0.667 0.133 GO:0006488 BP 1 dolichol-linked oligosaccharide biosynthetic process 1 Q86SQ9,Q96E22 484 1.87e-04 56 3 2 0.667 0.036 GO:0016765 MF 1 transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Q86SQ9,Q96E22 484 2.29e-04 62 3 2 0.667 0.032 GO:0046165 BP 1 alcohol biosynthetic process 1 Q86SQ9,Q96E22 484 2.76e-04 68 3 2 0.667 0.029 GO:0006720 BP 1 isoprenoid metabolic process 1 Q86SQ9,Q96E22 484 2.79e-04 52 3 2 0.667 0.038 REAC:446219 rea 1 Synthesis of substrates in N-glycan biosythesis 1 Q86SQ9,Q96E22 484 4.37e-04 65 3 2 0.667 0.031 REAC:446193 rea 1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 1 Q86SQ9,Q96E22 484 6.22e-04 102 3 2 0.667 0.020 GO:1901617 BP 1 organic hydroxy compound biosynthetic process 1 Q86SQ9,Q96E22 484 7.01e-04 1 3 1 0.333 1.000 GO:0019408 BP 1 dolichol biosynthetic process 1 Q96E22 484 7.01e-04 1 3 1 0.333 1.000 GO:0002094 MF 1 polyprenyltransferase activity 1 Q86SQ9 484 1.49e-03 158 3 2 0.667 0.013 GO:0006066 BP 1 alcohol metabolic process 1 Q86SQ9,Q96E22 484 1.49e-03 158 3 2 0.667 0.013 GO:0008654 BP 1 phospholipid biosynthetic process 1 Q86SQ9,Q96E22 484 2.10e-03 3 3 1 0.333 0.333 GO:0032380 BP 1 regulation of intracellular sterol transport 1 Q96E22 484 2.10e-03 3 3 1 0.333 0.333 GO:0019348 BP 1 dolichol metabolic process 1 Q96E22 484 2.10e-03 3 3 1 0.333 0.333 GO:0032383 BP 1 regulation of intracellular cholesterol transport 1 Q96E22 484 2.10e-03 3 3 1 0.333 0.333 GO:0032377 BP 1 regulation of intracellular lipid transport 1 Q96E22 484 3.01e-03 359 3 2 0.667 0.006 MI:hsa-miR-125b-1* mi 1 MI:hsa-miR-125b-1* 1 Q86SQ9,Q8IVH2 484 3.19e-03 231 3 2 0.667 0.009 GO:1901615 BP 1 organic hydroxy compound metabolic process 1 Q86SQ9,Q96E22 484 3.44e-03 240 3 2 0.667 0.008 GO:0006644 BP 1 phospholipid metabolic process 1 Q86SQ9,Q96E22 484 5.50e-03 304 3 2 0.667 0.007 GO:0044283 BP 1 small molecule biosynthetic process 1 Q86SQ9,Q96E22 484 6.33e-03 248 3 2 0.667 0.008 REAC:446203 rea 1 Asparagine N-linked glycosylation 1 Q86SQ9,Q96E22 484 6.63e-03 334 3 2 0.667 0.006 GO:0090407 BP 1 organophosphate biosynthetic process 1 Q86SQ9,Q96E22 484 7.00e-03 10 3 1 0.333 0.100 GO:0032367 BP 1 intracellular cholesterol transport 1 Q96E22 484 7.70e-03 11 3 1 0.333 0.091 GO:0032366 BP 1 intracellular sterol transport 1 Q96E22 484 7.99e-03 367 3 2 0.667 0.005 GO:0008610 BP 1 lipid biosynthetic process 1 Q86SQ9,Q96E22 484 1.28e-02 466 3 2 0.667 0.004 GO:1901137 BP 1 carbohydrate derivative biosynthetic process 1 Q86SQ9,Q96E22 484 1.54e-02 22 3 1 0.333 0.045 GO:0032365 BP 1 intracellular lipid transport 1 Q96E22 484 1.64e-02 528 3 2 0.667 0.004 GO:0005789 CC 1 endoplasmic reticulum membrane 1 Q86SQ9,Q96E22 484 1.68e-02 534 3 2 0.667 0.004 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 Q86SQ9,Q96E22 484 1.75e-02 25 3 1 0.333 0.040 GO:0032371 BP 1 regulation of sterol transport 1 Q96E22 484 1.75e-02 25 3 1 0.333 0.040 GO:0032374 BP 1 regulation of cholesterol transport 1 Q96E22 484 2.34e-02 633 3 2 0.667 0.003 GO:0044255 BP 1 cellular lipid metabolic process 1 Q86SQ9,Q96E22 484 2.53e-02 658 3 2 0.667 0.003 GO:0044432 CC 1 endoplasmic reticulum part 1 Q86SQ9,Q96E22 484 2.65e-02 674 3 2 0.667 0.003 GO:0019637 BP 1 organophosphate metabolic process 1 Q86SQ9,Q96E22 484 3.00e-02 43 3 1 0.333 0.023 GO:0032368 BP 1 regulation of lipid transport 1 Q96E22 484 3.40e-02 765 3 2 0.667 0.003 GO:0006629 BP 1 lipid metabolic process 1 Q86SQ9,Q96E22 484 3.42e-02 49 3 1 0.333 0.020 GO:0030301 BP 1 cholesterol transport 1 Q96E22 484 3.56e-02 51 3 1 0.333 0.020 GO:0015918 BP 1 sterol transport 1 Q96E22 484 3.66e-02 1241 3 2 0.667 0.002 HPA:008010_03 hpa 1 cervix, uterine; glandular cells[Uncertain,High] 1 Q86SQ9,Q8IVH2 484 3.69e-02 798 3 2 0.667 0.003 GO:1901135 BP 1 carbohydrate derivative metabolic process 1 Q86SQ9,Q96E22 484 3.94e-02 3675 3 3 1.000 0.001 HPA:040040_01 hpa 1 soft tissue 2; peripheral nerve[Uncertain,Low] 1 Q86SQ9,Q8IVH2,Q96E22 484 4.10e-02 1317 3 2 0.667 0.002 HPA:040040_11 hpa 1 soft tissue 2; peripheral nerve[Supportive,Low] 1 Q86SQ9,Q96E22 484 4.18e-02 851 3 2 0.667 0.002 GO:0044711 BP 1 single-organism biosynthetic process 1 Q86SQ9,Q96E22 484 4.22e-02 1337 3 2 0.667 0.001 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 Q86SQ9,Q96E22 484 4.58e-02 1396 3 2 0.667 0.001 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 Q86SQ9,Q96E22 484 4.66e-02 1408 3 2 0.667 0.001 HPA:004020_03 hpa 1 breast; glandular cells[Uncertain,High] 1 Q86SQ9,Q8IVH2 484 4.73e-02 1419 3 2 0.667 0.001 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 Q86SQ9,Q96E22 484 4.83e-02 3931 3 3 1.000 0.001 HPA:040010_01 hpa 1 soft tissue 2; adipocytes[Uncertain,Low] 1 Q86SQ9,Q8IVH2,Q96E22 484 4.98e-02 1459 3 2 0.667 0.001 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 Q86SQ9,Q96E22 484 5.00e-02 1 3 1 0.333 1.000 OMIM:613861 omi 1 RETINITIS PIGMENTOSA 59; RP59 1 Q86SQ9 484 5.00e-02 6 3 1 0.333 0.167 TF:M05496_0 tf 1 Factor: Tbx22; motif: ATTTMACACCTA; match class: 0 1 Q8IVH2 484 5.00e-02 712 3 2 0.667 0.003 REAC:597592 rea 1 Post-translational protein modification 1 Q86SQ9,Q96E22 484 5.00e-02 6 3 1 0.333 0.167 TF:M06607_0 tf 1 Factor: ZNF560; motif: NGRTATTGCCGA; match class: 0 1 Q96E22 484 5.00e-02 22 3 2 0.667 0.091 KEGG:00900 keg 1 Terpenoid backbone biosynthesis 1 Q86SQ9,Q96E22 484 5.00e-02 933 3 2 0.667 0.002 GO:0005783 CC 1 endoplasmic reticulum 1 Q86SQ9,Q96E22 485 7.71e-06 12 3 2 0.667 0.167 GO:0000940 CC 1 condensed chromosome outer kinetochore 1 Q8IX90,Q8WVK7 485 2.95e-05 23 3 2 0.667 0.087 GO:0000777 CC 1 condensed chromosome kinetochore 1 Q8IX90,Q8WVK7 485 5.08e-05 30 3 2 0.667 0.067 GO:0031110 BP 1 regulation of microtubule polymerization or depolymerization 1 Q8IX90,Q8WVK7 485 5.43e-05 31 3 2 0.667 0.065 GO:0000779 CC 1 condensed chromosome, centromeric region 1 Q8IX90,Q8WVK7 485 1.31e-04 48 3 2 0.667 0.042 GO:0005876 CC 1 spindle microtubule 1 Q8IX90,Q8WVK7 485 1.93e-04 58 3 2 0.667 0.034 GO:0031109 BP 1 microtubule polymerization or depolymerization 1 Q8IX90,Q8WVK7 485 4.05e-04 84 3 2 0.667 0.024 GO:0070507 BP 1 regulation of microtubule cytoskeleton organization 1 Q8IX90,Q8WVK7 485 4.76e-04 91 3 2 0.667 0.022 GO:0000776 CC 1 kinetochore 1 Q8IX90,Q8WVK7 485 5.52e-04 98 3 2 0.667 0.020 GO:0000793 CC 1 condensed chromosome 1 Q8IX90,Q8WVK7 485 6.22e-04 104 3 2 0.667 0.019 GO:0032886 BP 1 regulation of microtubule-based process 1 Q8IX90,Q8WVK7 485 8.43e-04 121 3 2 0.667 0.017 GO:0000775 CC 1 chromosome, centromeric region 1 Q8IX90,Q8WVK7 485 1.59e-03 166 3 2 0.667 0.012 GO:0005874 CC 1 microtubule 1 Q8IX90,Q8WVK7 485 1.74e-03 174 3 2 0.667 0.011 GO:0005819 CC 1 spindle 1 Q8IX90,Q8WVK7 485 3.04e-03 230 3 2 0.667 0.009 GO:0098687 CC 1 chromosomal region 1 Q8IX90,Q8WVK7 485 3.20e-03 236 3 2 0.667 0.008 GO:0007067 BP 1 mitotic nuclear division 1 Q8IX90,Q8WVK7 485 3.97e-03 263 3 2 0.667 0.008 GO:0007059 BP 1 chromosome segregation 1 Q8IX90,Q8WVK7 485 4.03e-03 265 3 2 0.667 0.008 GO:0051493 BP 1 regulation of cytoskeleton organization 1 Q8IX90,Q8WVK7 485 4.06e-03 266 3 2 0.667 0.008 GO:0099513 CC 1 polymeric cytoskeletal fiber 1 Q8IX90,Q8WVK7 485 4.30e-03 274 3 2 0.667 0.007 GO:0099512 CC 1 supramolecular fiber 1 Q8IX90,Q8WVK7 485 4.30e-03 274 3 2 0.667 0.007 GO:0099081 CC 1 supramolecular polymer 1 Q8IX90,Q8WVK7 485 4.95e-03 294 3 2 0.667 0.007 GO:0099080 CC 1 supramolecular complex 1 Q8IX90,Q8WVK7 485 5.46e-03 309 3 2 0.667 0.006 GO:0000280 BP 1 nuclear division 1 Q8IX90,Q8WVK7 485 6.22e-03 330 3 2 0.667 0.006 GO:0000226 BP 1 microtubule cytoskeleton organization 1 Q8IX90,Q8WVK7 485 6.60e-03 340 3 2 0.667 0.006 GO:0048285 BP 1 organelle fission 1 Q8IX90,Q8WVK7 485 1.20e-02 459 3 2 0.667 0.004 GO:0007017 BP 1 microtubule-based process 1 Q8IX90,Q8WVK7 485 1.80e-02 565 3 2 0.667 0.004 GO:0044427 CC 1 chromosomal part 1 Q8IX90,Q8WVK7 485 2.09e-02 609 3 2 0.667 0.003 GO:0005694 CC 1 chromosome 1 Q8IX90,Q8WVK7 485 2.42e-02 657 3 2 0.667 0.003 GO:1903047 BP 1 mitotic cell cycle process 1 Q8IX90,Q8WVK7 485 2.80e-02 707 3 2 0.667 0.003 GO:0033043 BP 1 regulation of organelle organization 1 Q8IX90,Q8WVK7 485 2.91e-02 721 3 2 0.667 0.003 GO:0000278 BP 1 mitotic cell cycle 1 Q8IX90,Q8WVK7 485 3.21e-02 758 3 2 0.667 0.003 GO:0007010 BP 1 cytoskeleton organization 1 Q8IX90,Q8WVK7 485 3.30e-02 769 3 2 0.667 0.003 GO:0015630 CC 1 microtubule cytoskeleton 1 Q8IX90,Q8WVK7 485 4.17e-02 3743 3 3 1.000 0.001 HPA:006020_02 hpa 1 cerebellum; cells in granular layer[Uncertain,Medium] 1 Q8IX90,Q8WVK7,Q86SE5 485 4.39e-02 99 3 1 0.333 0.010 REAC:2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 Q8WVK7 485 4.74e-02 107 3 1 0.333 0.009 REAC:68877 rea 1 Mitotic Prometaphase 1 Q8WVK7 485 4.81e-02 933 3 2 0.667 0.002 GO:0044430 CC 1 cytoskeletal part 1 Q8IX90,Q8WVK7 485 5.00e-02 2 3 1 0.333 0.500 TF:M04242_0 tf 1 Factor: FOXG1; motif: RTAAACAATNGTAAACA; match class: 0 1 Q86SE5 485 5.00e-02 952 3 2 0.667 0.002 GO:0022402 BP 1 cell cycle process 1 Q8IX90,Q8WVK7 485 5.00e-02 113 3 1 0.333 0.009 REAC:5663220 rea 1 RHO GTPases Activate Formins 1 Q8WVK7 486 1.93e-03 3 2 1 0.500 0.333 REAC:77305 rea 1 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1 P49748 486 2.00e-03 1 2 1 0.500 1.000 GO:0030372 MF 1 high molecular weight B cell growth factor receptor binding 1 P40222 486 5.15e-03 8 2 1 0.500 0.125 REAC:77286 rea 1 mitochondrial fatty acid beta-oxidation of saturated fatty acids 1 P49748 486 6.01e-03 3 2 1 0.500 0.333 GO:0017099 MF 1 very-long-chain-acyl-CoA dehydrogenase activity 1 P49748 486 8.01e-03 4 2 1 0.500 0.250 GO:0004466 MF 1 long-chain-acyl-CoA dehydrogenase activity 1 P49748 486 8.01e-03 4 2 1 0.500 0.250 GO:0042760 BP 1 very long-chain fatty acid catabolic process 1 P49748 486 8.02e-03 8 2 1 0.500 0.125 TF:M04102_0 tf 1 Factor: RFX5; motif: NGTTRCCATRGCAACN; match class: 0 1 P49748 486 1.03e-02 511 2 2 1.000 0.004 TF:M04428_0 tf 1 Factor: PITX1; motif: NTTAATCCN; match class: 0 1 P49748,P40222 486 1.20e-02 6 2 1 0.500 0.167 GO:0046322 BP 1 negative regulation of fatty acid oxidation 1 P49748 486 1.20e-02 12 2 1 0.500 0.083 TF:M06118_0 tf 1 Factor: ZNF23; motif: NGGTAAWGGTTN; match class: 0 1 P49748 486 1.25e-02 2 2 1 0.500 0.500 HP:0001958 hp 1 Nonketotic hypoglycemia 1 P49748 486 1.29e-02 20 2 1 0.500 0.050 REAC:77289 rea 1 Mitochondrial Fatty Acid Beta-Oxidation 1 P49748 486 1.80e-02 9 2 1 0.500 0.111 GO:0045717 BP 1 negative regulation of fatty acid biosynthetic process 1 P49748 486 1.88e-02 3 2 1 0.500 0.333 HP:0009045 hp 1 Exercise-induced rhabdomyolysis 1 P49748 486 2.00e-02 10 2 1 0.500 0.100 GO:0001659 BP 1 temperature homeostasis 1 P49748 486 2.60e-02 13 2 1 0.500 0.077 GO:0090181 BP 1 regulation of cholesterol metabolic process 1 P49748 486 2.80e-02 14 2 1 0.500 0.071 GO:0045922 BP 1 negative regulation of fatty acid metabolic process 1 P49748 486 2.80e-02 14 2 1 0.500 0.071 GO:0052890 MF 1 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1 P49748 486 3.00e-02 15 2 1 0.500 0.067 GO:0003995 MF 1 acyl-CoA dehydrogenase activity 1 P49748 486 3.00e-02 15 2 1 0.500 0.067 GO:0046320 BP 1 regulation of fatty acid oxidation 1 P49748 486 3.15e-02 49 2 1 0.500 0.020 REAC:381038 rea 1 XBP1(S) activates chaperone genes 1 P49748 486 3.24e-02 908 2 2 1.000 0.002 TF:M03844_1 tf 1 Factor: SAP-1a; motif: CWTCCKGT; match class: 1 1 P49748,P40222 486 3.24e-02 908 2 2 1.000 0.002 TF:M07282_1 tf 1 Factor: ER71; motif: CWTCCTGT; match class: 1 1 P49748,P40222 486 3.28e-02 51 2 1 0.500 0.020 REAC:381070 rea 1 IRE1alpha activates chaperones 1 P49748 486 3.40e-02 17 2 1 0.500 0.059 GO:0033539 BP 1 fatty acid beta-oxidation using acyl-CoA dehydrogenase 1 P49748 486 3.60e-02 18 2 1 0.500 0.056 GO:0000038 BP 1 very long-chain fatty acid metabolic process 1 P49748 486 3.61e-02 36 2 1 0.500 0.028 TF:M06115_0 tf 1 Factor: ZNF28; motif: NGGGGCGGCAGC; match class: 0 1 P49748 486 3.80e-02 19 2 1 0.500 0.053 GO:0042304 BP 1 regulation of fatty acid biosynthetic process 1 P49748 486 3.81e-02 38 2 1 0.500 0.026 TF:M06080_1 tf 1 Factor: ZNF99; motif: KGGKGTGAGA; match class: 1 1 P49748 486 4.00e-02 20 2 1 0.500 0.050 GO:0000062 MF 1 fatty-acyl-CoA binding 1 P49748 486 4.42e-02 1060 2 2 1.000 0.002 TF:M05427_0 tf 1 Factor: ZNF516; motif: YGTAAAGCCT; match class: 0 1 P49748,P40222 486 4.71e-02 47 2 1 0.500 0.021 TF:M07207_1 tf 1 Factor: EBF1; motif: NTCCCCWGGGA; match class: 1 1 P49748 486 4.71e-02 47 2 1 0.500 0.021 TF:M01973_1 tf 1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 1 P49748 486 5.00e-02 25 2 1 0.500 0.040 GO:0051055 BP 1 negative regulation of lipid biosynthetic process 1 P49748 486 5.00e-02 8 2 1 0.500 0.125 HP:0010966 hp 1 Abnormality of fatty-acid anion metabolism 1 P49748 486 5.00e-02 8 2 1 0.500 0.125 HP:0010967 hp 1 Abnormality of carnitine metabolism 1 P49748 486 5.00e-02 8 2 1 0.500 0.125 HP:0003234 hp 1 Decreased plasma carnitine 1 P49748 486 5.00e-02 1 2 1 0.500 1.000 OMIM:201475 omi 1 ACYL-CoA DEHYDROGENASE, VERY LONG-CHAIN, DEFICIENCY OF; ACADVLD;;VLCAD DEFICIENCY 1 P49748 486 5.00e-02 78 2 1 0.500 0.013 REAC:381119 rea 1 Unfolded Protein Response (UPR) 1 P49748 486 5.00e-02 38 2 1 0.500 0.026 KEGG:00071 keg 1 Fatty acid degradation 1 P49748 486 5.00e-02 8 2 1 0.500 0.125 HP:0003738 hp 1 Exercise-induced myalgia 1 P49748 486 5.00e-02 10 2 1 0.500 0.100 CORUM:5286 cor 1 TNF-alpha/NF-kappa B signaling complex 10 1 P40222 486 5.00e-02 1127 2 2 1.000 0.002 TF:M01045_0 tf 1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 0 1 P49748,P40222 487 3.25e-03 2 4 1 0.250 0.500 REAC:5627083 rea 1 RHO GTPases regulate CFTR trafficking 1 Q9HD26 487 8.34e-03 1 4 1 0.250 1.000 GO:0043002 BP 1 negative regulation of Golgi to plasma membrane CFTR protein transport 1 Q9HD26 487 8.34e-03 1 4 1 0.250 1.000 GO:0043004 BP 1 cytoplasmic sequestering of CFTR protein 1 Q9HD26 487 8.34e-03 1 4 1 0.250 1.000 GO:0042999 BP 1 regulation of Golgi to plasma membrane CFTR protein transport 1 Q9HD26 487 9.52e-03 459 4 2 0.500 0.004 MI:hsa-miR-299-5p mi 1 MI:hsa-miR-299-5p 1 Q8IZU1,Q99457 487 9.76e-03 465 4 2 0.500 0.004 MI:hsa-let-7i* mi 1 MI:hsa-let-7i* 1 Q6NZI2,Q8IZU1 487 1.15e-02 507 4 2 0.500 0.004 MI:hsa-miR-141 mi 1 MI:hsa-miR-141 1 Q8IZU1,Q99457 487 1.19e-02 516 4 2 0.500 0.004 MI:hsa-miR-429 mi 1 MI:hsa-miR-429 1 Q8IZU1,Q99457 487 1.25e-02 1 4 1 0.250 1.000 OMIM:613327 omi 1 LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 4; CGL4;;BERARDINELLI-SEIP CONGENITAL LIPODYSTROPHY, TYPE 4, WITH MUSCULARDYSTROPHY;;LIPODYSTROPHY, BERARDINELLI-SEIP CONGENITAL, TYPE 4, WITH MUSCULARDYSTROPHY 1 Q6NZI2 487 1.42e-02 565 4 2 0.500 0.004 MI:hsa-miR-200a mi 1 MI:hsa-miR-200a 1 Q8IZU1,Q99457 487 1.67e-02 2 4 1 0.250 0.500 GO:0043000 BP 1 Golgi to plasma membrane CFTR protein transport 1 Q9HD26 487 2.50e-02 3 4 1 0.250 0.333 GO:0042134 MF 1 rRNA primary transcript binding 1 Q6NZI2 487 2.50e-02 3 4 1 0.250 0.333 GO:0042997 BP 1 negative regulation of Golgi to plasma membrane protein transport 1 Q9HD26 487 3.33e-02 4 4 1 0.250 0.250 GO:0045176 BP 1 apical protein localization 1 Q9HD26 487 4.95e-02 136 4 1 0.250 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 Q6NZI2 487 5.00e-02 1 4 1 0.250 1.000 TF:M00647_1 tf 1 Factor: LXR; motif: TGGGGTYACTNGCGGTCA; match class: 1 1 Q8IZU1 487 5.00e-02 4 4 1 0.250 0.250 OMIM:608594 omi 1 Congenital Generalized Lipodystrophy 1 Q6NZI2 487 5.00e-02 1 4 1 0.250 1.000 HP:0003719 hp 1 Muscle mounding 1 Q6NZI2 487 5.00e-02 31 4 1 0.250 0.032 REAC:73863 rea 1 RNA Polymerase I Transcription Termination 1 Q6NZI2 487 5.00e-02 6 4 1 0.250 0.167 GO:0008105 BP 1 asymmetric protein localization 1 Q9HD26 487 5.00e-02 6 4 1 0.250 0.167 GO:0042996 BP 1 regulation of Golgi to plasma membrane protein transport 1 Q9HD26 488 8.41e-10 37 4 4 1.000 0.108 REAC:69236 rea 1 G1 Phase 1 Q14209,Q01094,Q14188,Q16254 488 8.41e-10 37 4 4 1.000 0.108 REAC:69231 rea 1 Cyclin D associated events in G1 1 Q14209,Q01094,Q14188,Q16254 488 1.84e-07 138 4 4 1.000 0.029 REAC:453279 rea 1 Mitotic G1-G1/S phases 1 Q14209,Q01094,Q14188,Q16254 488 2.11e-07 25 4 3 0.750 0.120 REAC:1538133 rea 1 G0 and Early G1 1 Q01094,Q14188,Q16254 488 2.91e-07 117 4 4 1.000 0.034 KEGG:04110 keg 1 Cell cycle 1 Q14209,Q01094,Q14188,Q16254 488 3.72e-07 30 4 3 0.750 0.100 REAC:2559585 rea 1 Oncogene Induced Senescence 1 Q14209,Q01094,Q14188 488 7.38e-07 53 4 3 0.750 0.057 GO:0006977 BP 1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1 Q01094,Q14188,Q16254 488 7.82e-07 54 4 3 0.750 0.056 GO:1902400 BP 1 intracellular signal transduction involved in G1 DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 7.82e-07 54 4 3 0.750 0.056 GO:0072431 BP 1 signal transduction involved in mitotic G1 DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 8.27e-07 55 4 3 0.750 0.055 GO:1902403 BP 1 signal transduction involved in mitotic DNA integrity checkpoint 1 Q01094,Q14188,Q16254 488 8.27e-07 55 4 3 0.750 0.055 GO:1902402 BP 1 signal transduction involved in mitotic DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 8.27e-07 55 4 3 0.750 0.055 GO:0072413 BP 1 signal transduction involved in mitotic cell cycle checkpoint 1 Q01094,Q14188,Q16254 488 9.22e-07 57 4 3 0.750 0.053 GO:0072395 BP 1 signal transduction involved in cell cycle checkpoint 1 Q01094,Q14188,Q16254 488 9.22e-07 57 4 3 0.750 0.053 GO:0072401 BP 1 signal transduction involved in DNA integrity checkpoint 1 Q01094,Q14188,Q16254 488 9.22e-07 57 4 3 0.750 0.053 GO:0072422 BP 1 signal transduction involved in DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 1.08e-06 60 4 3 0.750 0.050 GO:0044819 BP 1 mitotic G1/S transition checkpoint 1 Q01094,Q14188,Q16254 488 1.08e-06 60 4 3 0.750 0.050 GO:0031571 BP 1 mitotic G1 DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 1.13e-06 61 4 3 0.750 0.049 GO:0044783 BP 1 G1 DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 1.30e-06 45 4 3 0.750 0.067 REAC:6791312 rea 1 TP53 Regulates Transcription of Cell Cycle Genes 1 Q01094,Q14188,Q16254 488 1.41e-06 335 4 4 1.000 0.012 GO:0008134 MF 1 transcription factor binding 1 Q14209,Q01094,Q14188,Q16254 488 1.65e-06 69 4 3 0.750 0.043 GO:0071158 BP 1 positive regulation of cell cycle arrest 1 Q01094,Q14188,Q16254 488 1.99e-06 4 4 2 0.500 0.500 REAC:111448 rea 1 Activation of NOXA and translocation to mitochondria 1 Q01094,Q14188 488 2.12e-06 75 4 3 0.750 0.040 GO:2000134 BP 1 negative regulation of G1/S transition of mitotic cell cycle 1 Q01094,Q14188,Q16254 488 2.21e-06 76 4 3 0.750 0.039 GO:1902807 BP 1 negative regulation of cell cycle G1/S phase transition 1 Q01094,Q14188,Q16254 488 2.58e-06 80 4 3 0.750 0.037 GO:0044773 BP 1 mitotic DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 3.33e-06 87 4 3 0.750 0.034 GO:0030330 BP 1 DNA damage response, signal transduction by p53 class mediator 1 Q01094,Q14188,Q16254 488 3.33e-06 87 4 3 0.750 0.034 GO:0071156 BP 1 regulation of cell cycle arrest 1 Q01094,Q14188,Q16254 488 3.33e-06 87 4 3 0.750 0.034 GO:0044774 BP 1 mitotic DNA integrity checkpoint 1 Q01094,Q14188,Q16254 488 4.93e-06 99 4 3 0.750 0.030 GO:0042770 BP 1 signal transduction in response to DNA damage 1 Q01094,Q14188,Q16254 488 5.08e-06 100 4 3 0.750 0.030 GO:2000045 BP 1 regulation of G1/S transition of mitotic cell cycle 1 Q01094,Q14188,Q16254 488 6.16e-06 75 4 3 0.750 0.040 REAC:2559580 rea 1 Oxidative Stress Induced Senescence 1 Q14209,Q01094,Q14188 488 6.23e-06 107 4 3 0.750 0.028 GO:1902806 BP 1 regulation of cell cycle G1/S phase transition 1 Q01094,Q14188,Q16254 488 8.16e-06 117 4 3 0.750 0.026 GO:1901991 BP 1 negative regulation of mitotic cell cycle phase transition 1 Q01094,Q14188,Q16254 488 8.81e-06 120 4 3 0.750 0.025 GO:1901988 BP 1 negative regulation of cell cycle phase transition 1 Q01094,Q14188,Q16254 488 9.29e-06 8 4 2 0.500 0.250 REAC:139915 rea 1 Activation of PUMA and translocation to mitochondria 1 Q01094,Q14188 488 9.97e-06 125 4 3 0.750 0.024 GO:0000077 BP 1 DNA damage checkpoint 1 Q01094,Q14188,Q16254 488 1.07e-05 128 4 3 0.750 0.023 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 Q01094,Q14188,Q16254 488 1.26e-05 135 4 3 0.750 0.022 GO:0031570 BP 1 DNA integrity checkpoint 1 Q01094,Q14188,Q16254 488 1.82e-05 11 4 2 0.500 0.182 REAC:68689 rea 1 CDC6 association with the ORC:origin complex 1 Q14209,Q01094 488 2.10e-05 160 4 3 0.750 0.019 GO:0090068 BP 1 positive regulation of cell cycle process 1 Q01094,Q14188,Q16254 488 2.11e-05 448 4 4 1.000 0.009 REAC:69278 rea 1 Cell Cycle, Mitotic 1 Q14209,Q01094,Q14188,Q16254 488 2.26e-05 164 4 3 0.750 0.018 GO:0010948 BP 1 negative regulation of cell cycle process 1 Q01094,Q14188,Q16254 488 2.29e-05 671 4 4 1.000 0.006 GO:0003700 MF 1 transcription factor activity, sequence-specific DNA binding 1 Q14209,Q01094,Q14188,Q16254 488 2.29e-05 671 4 4 1.000 0.006 GO:0001071 MF 1 nucleic acid binding transcription factor activity 1 Q14209,Q01094,Q14188,Q16254 488 2.52e-05 170 4 3 0.750 0.018 GO:0045930 BP 1 negative regulation of mitotic cell cycle 1 Q01094,Q14188,Q16254 488 2.59e-05 13 4 2 0.500 0.154 REAC:113501 rea 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1 Q01094,Q14188 488 2.89e-05 178 4 3 0.750 0.017 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 Q01094,Q14188,Q16254 488 2.99e-05 180 4 3 0.750 0.017 GO:0007050 BP 1 cell cycle arrest 1 Q01094,Q14188,Q16254 488 3.02e-05 14 4 2 0.500 0.143 REAC:69298 rea 1 Association of licensing factors with the pre-replicative complex 1 Q14209,Q01094 488 3.14e-05 183 4 3 0.750 0.016 GO:0000075 BP 1 cell cycle checkpoint 1 Q01094,Q14188,Q16254 488 3.24e-05 185 4 3 0.750 0.016 GO:0044843 BP 1 cell cycle G1/S phase transition 1 Q01094,Q14188,Q16254 488 3.88e-05 138 4 3 0.750 0.022 REAC:2559583 rea 1 Cellular Senescence 1 Q14209,Q01094,Q14188 488 4.48e-05 206 4 3 0.750 0.015 GO:0072331 BP 1 signal transduction by p53 class mediator 1 Q01094,Q14188,Q16254 488 4.50e-05 17 4 2 0.500 0.118 REAC:6804114 rea 1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1 Q14188,Q16254 488 4.70e-05 547 4 4 1.000 0.007 REAC:1640170 rea 1 Cell Cycle 1 Q14209,Q01094,Q14188,Q16254 488 5.07e-05 18 4 2 0.500 0.111 REAC:69205 rea 1 G1/S-Specific Transcription 1 Q01094,Q14188 488 5.09e-05 215 4 3 0.750 0.014 GO:0045787 BP 1 positive regulation of cell cycle 1 Q01094,Q14188,Q16254 488 6.56e-05 234 4 3 0.750 0.013 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 Q01094,Q14188,Q16254 488 7.35e-05 243 4 3 0.750 0.012 GO:1901987 BP 1 regulation of cell cycle phase transition 1 Q01094,Q14188,Q16254 488 8.20e-05 922 4 4 1.000 0.004 GO:0003677 MF 1 DNA binding 1 Q14209,Q01094,Q14188,Q16254 488 1.07e-04 26 4 2 0.500 0.077 REAC:1912408 rea 1 Pre-NOTCH Transcription and Translation 1 Q01094,Q14188 488 1.16e-04 27 4 2 0.500 0.074 REAC:114452 rea 1 Activation of BH3-only proteins 1 Q01094,Q14188 488 1.34e-04 29 4 2 0.500 0.069 REAC:2173796 rea 1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1 Q14188,Q16254 488 1.85e-04 34 4 2 0.500 0.059 REAC:113510 rea 1 E2F mediated regulation of DNA replication 1 Q01094,Q14188 488 2.18e-04 1177 4 4 1.000 0.003 GO:0006366 BP 1 transcription from RNA polymerase II promoter 1 Q14209,Q01094,Q14188,Q16254 488 2.44e-04 363 4 3 0.750 0.008 GO:0007346 BP 1 regulation of mitotic cell cycle 1 Q01094,Q14188,Q16254 488 2.44e-04 39 4 2 0.500 0.051 REAC:109606 rea 1 Intrinsic Pathway for Apoptosis 1 Q01094,Q14188 488 2.70e-04 41 4 2 0.500 0.049 REAC:2173793 rea 1 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1 Q14188,Q16254 488 2.71e-04 376 4 3 0.750 0.008 GO:0045786 BP 1 negative regulation of cell cycle 1 Q01094,Q14188,Q16254 488 2.84e-04 42 4 2 0.500 0.048 REAC:1912422 rea 1 Pre-NOTCH Expression and Processing 1 Q01094,Q14188 488 3.14e-04 36 4 2 0.500 0.056 KEGG:05219 keg 1 Bladder cancer 1 Q14209,Q01094 488 3.31e-04 402 4 3 0.750 0.007 GO:0010564 BP 1 regulation of cell cycle process 1 Q01094,Q14188,Q16254 488 3.54e-04 411 4 3 0.750 0.007 GO:0044772 BP 1 mitotic cell cycle phase transition 1 Q01094,Q14188,Q16254 488 3.91e-04 425 4 3 0.750 0.007 GO:0044770 BP 1 cell cycle phase transition 1 Q01094,Q14188,Q16254 488 4.10e-04 432 4 3 0.750 0.007 GO:0044212 MF 1 transcription regulatory region DNA binding 1 Q14209,Q01094,Q16254 488 4.10e-04 432 4 3 0.750 0.007 GO:0001067 MF 1 regulatory region nucleic acid binding 1 Q14209,Q01094,Q16254 488 4.10e-04 432 4 3 0.750 0.007 GO:0000975 MF 1 regulatory region DNA binding 1 Q14209,Q01094,Q16254 488 5.32e-04 331 4 3 0.750 0.009 REAC:3700989 rea 1 Transcriptional Regulation by TP53 1 Q01094,Q14188,Q16254 488 6.29e-04 84 4 2 0.500 0.024 GO:0001047 MF 1 core promoter binding 1 Q14209,Q01094 488 6.58e-04 52 4 2 0.500 0.038 KEGG:05223 keg 1 Non-small cell lung cancer 1 Q14209,Q01094 488 6.96e-04 516 4 3 0.750 0.006 GO:0045944 BP 1 positive regulation of transcription from RNA polymerase II promoter 1 Q01094,Q14188,Q16254 488 7.10e-04 54 4 2 0.500 0.037 KEGG:05218 keg 1 Melanoma 1 Q14209,Q01094 488 7.25e-04 67 4 2 0.500 0.030 REAC:68867 rea 1 Assembly of the pre-replicative complex 1 Q14209,Q01094 488 7.25e-04 67 4 2 0.500 0.030 REAC:170834 rea 1 Signaling by TGF-beta Receptor Complex 1 Q14188,Q16254 488 7.89e-04 378 4 3 0.750 0.008 REAC:2262752 rea 1 Cellular responses to stress 1 Q14209,Q01094,Q14188 488 7.91e-04 57 4 2 0.500 0.035 KEGG:05214 keg 1 Glioma 1 Q14209,Q01094 488 9.06e-04 61 4 2 0.500 0.033 KEGG:05212 keg 1 Pancreatic cancer 1 Q14209,Q01094 488 9.09e-04 75 4 2 0.500 0.027 REAC:69304 rea 1 Regulation of DNA replication 1 Q14209,Q01094 488 1.05e-03 592 4 3 0.750 0.005 GO:0006974 BP 1 cellular response to DNA damage stimulus 1 Q01094,Q14188,Q16254 488 1.11e-03 83 4 2 0.500 0.024 REAC:68874 rea 1 M/G1 Transition 1 Q14209,Q01094 488 1.11e-03 83 4 2 0.500 0.024 REAC:69002 rea 1 DNA Replication Pre-Initiation 1 Q14209,Q01094 488 1.16e-03 69 4 2 0.500 0.029 KEGG:05220 keg 1 Chronic myeloid leukemia 1 Q14209,Q01094 488 1.38e-03 1865 4 4 1.000 0.002 GO:0006351 BP 1 transcription, DNA-templated 1 Q14209,Q01094,Q14188,Q16254 488 1.40e-03 1872 4 4 1.000 0.002 GO:0097659 BP 1 nucleic acid-templated transcription 1 Q14209,Q01094,Q14188,Q16254 488 1.40e-03 2 4 1 0.250 0.500 GO:0071930 BP 1 negative regulation of transcription involved in G1/S transition of mitotic cell cycle 1 Q01094 488 1.42e-03 657 4 3 0.750 0.005 GO:1903047 BP 1 mitotic cell cycle process 1 Q01094,Q14188,Q16254 488 1.44e-03 77 4 2 0.500 0.026 KEGG:05215 keg 1 Prostate cancer 1 Q14209,Q01094 488 1.46e-03 95 4 2 0.500 0.021 REAC:157118 rea 1 Signaling by NOTCH 1 Q01094,Q14188 488 1.57e-03 679 4 3 0.750 0.004 GO:0051726 BP 1 regulation of cell cycle 1 Q01094,Q14188,Q16254 488 1.72e-03 84 4 2 0.500 0.024 KEGG:05222 keg 1 Small cell lung cancer 1 Q14209,Q01094 488 1.75e-03 1980 4 4 1.000 0.002 GO:0032774 BP 1 RNA biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 1.81e-03 106 4 2 0.500 0.019 REAC:69306 rea 1 DNA Replication 1 Q14209,Q01094 488 1.84e-03 87 4 2 0.500 0.023 KEGG:01522 keg 1 Endocrine resistance 1 Q14209,Q01094 488 1.87e-03 721 4 3 0.750 0.004 GO:0000278 BP 1 mitotic cell cycle 1 Q01094,Q14188,Q16254 488 2.03e-03 741 4 3 0.750 0.004 GO:0045893 BP 1 positive regulation of transcription, DNA-templated 1 Q01094,Q14188,Q16254 488 2.03e-03 741 4 3 0.750 0.004 GO:1903508 BP 1 positive regulation of nucleic acid-templated transcription 1 Q01094,Q14188,Q16254 488 2.10e-03 3 4 1 0.250 0.333 GO:0035189 CC 1 Rb-E2F complex 1 Q01094 488 2.13e-03 115 4 2 0.500 0.017 REAC:69206 rea 1 G1/S Transition 1 Q01094,Q14188 488 2.21e-03 762 4 3 0.750 0.004 GO:1902680 BP 1 positive regulation of RNA biosynthetic process 1 Q01094,Q14188,Q16254 488 2.37e-03 2136 4 4 1.000 0.002 GO:0003676 MF 1 nucleic acid binding 1 Q14209,Q01094,Q14188,Q16254 488 2.46e-03 791 4 3 0.750 0.004 GO:0051254 BP 1 positive regulation of RNA metabolic process 1 Q01094,Q14188,Q16254 488 2.80e-03 4 4 1 0.250 0.250 GO:0070345 BP 1 negative regulation of fat cell proliferation 1 Q01094 488 3.01e-03 2267 4 4 1.000 0.002 GO:0034654 BP 1 nucleobase-containing compound biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 3.04e-03 112 4 2 0.500 0.018 KEGG:05224 keg 1 Breast cancer 1 Q14209,Q01094 488 3.22e-03 2305 4 4 1.000 0.002 GO:0019438 BP 1 aromatic compound biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 3.24e-03 2310 4 4 1.000 0.002 GO:0018130 BP 1 heterocycle biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 3.50e-03 5 4 1 0.250 0.200 GO:0070341 BP 1 fat cell proliferation 1 Q01094 488 3.50e-03 5 4 1 0.250 0.200 GO:1903251 BP 1 multi-ciliated epithelial cell differentiation 1 Q16254 488 3.50e-03 5 4 1 0.250 0.200 GO:0070344 BP 1 regulation of fat cell proliferation 1 Q01094 488 3.53e-03 628 4 3 0.750 0.005 REAC:212436 rea 1 Generic Transcription Pathway 1 Q01094,Q14188,Q16254 488 3.56e-03 896 4 3 0.750 0.003 GO:0010557 BP 1 positive regulation of macromolecule biosynthetic process 1 Q01094,Q14188,Q16254 488 3.58e-03 201 4 2 0.500 0.010 GO:0000790 CC 1 nuclear chromatin 1 Q01094,Q16254 488 3.62e-03 2374 4 4 1.000 0.002 GO:1901362 BP 1 organic cyclic compound biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 3.71e-03 124 4 2 0.500 0.016 KEGG:05161 keg 1 Hepatitis B 1 Q14209,Q01094 488 3.87e-03 922 4 3 0.750 0.003 GO:0010628 BP 1 positive regulation of gene expression 1 Q01094,Q14188,Q16254 488 4.00e-03 5 4 1 0.250 0.200 REAC:68911 rea 1 G2 Phase 1 Q01094 488 4.01e-03 933 4 3 0.750 0.003 GO:0045935 BP 1 positive regulation of nucleobase-containing compound metabolic process 1 Q01094,Q14188,Q16254 488 4.05e-03 159 4 2 0.500 0.013 REAC:109581 rea 1 Apoptosis 1 Q01094,Q14188 488 4.20e-03 162 4 2 0.500 0.012 REAC:5357801 rea 1 Programmed Cell Death 1 Q01094,Q14188 488 4.25e-03 952 4 3 0.750 0.003 GO:0022402 BP 1 cell cycle process 1 Q01094,Q14188,Q16254 488 4.30e-03 956 4 3 0.750 0.003 GO:0031328 BP 1 positive regulation of cellular biosynthetic process 1 Q01094,Q14188,Q16254 488 4.49e-03 970 4 3 0.750 0.003 GO:0006357 BP 1 regulation of transcription from RNA polymerase II promoter 1 Q01094,Q14188,Q16254 488 4.51e-03 971 4 3 0.750 0.003 GO:0009891 BP 1 positive regulation of biosynthetic process 1 Q01094,Q14188,Q16254 488 4.65e-03 139 4 2 0.500 0.014 KEGG:05206 keg 1 MicroRNAs in cancer 1 Q14209,Q01094 488 4.66e-03 2529 4 4 1.000 0.002 GO:0005654 CC 1 nucleoplasm 1 Q14209,Q01094,Q14188,Q16254 488 4.81e-03 993 4 3 0.750 0.003 GO:0051173 BP 1 positive regulation of nitrogen compound metabolic process 1 Q01094,Q14188,Q16254 488 4.96e-03 317 4 2 0.500 0.006 HPA:035020_13 hpa 1 skin 1; fibroblasts[Supportive,High] 1 Q01094,Q14188 488 5.30e-03 2612 4 4 1.000 0.002 GO:1901363 MF 1 heterocyclic compound binding 1 Q14209,Q01094,Q14188,Q16254 488 5.43e-03 2627 4 4 1.000 0.002 GO:0016070 BP 1 RNA metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 5.71e-03 2660 4 4 1.000 0.002 GO:0097159 MF 1 organic cyclic compound binding 1 Q14209,Q01094,Q14188,Q16254 488 5.83e-03 1263 4 3 0.750 0.002 HPA:029010_03 hpa 1 placenta; decidual cells[Uncertain,High] 1 Q01094,Q14188,Q16254 488 6.12e-03 2707 4 4 1.000 0.001 GO:0044271 BP 1 cellular nitrogen compound biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 6.30e-03 9 4 1 0.250 0.111 GO:0044458 BP 1 motile cilium assembly 1 Q16254 488 6.71e-03 2770 4 4 1.000 0.001 GO:0034645 BP 1 cellular macromolecule biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 6.99e-03 1128 4 3 0.750 0.003 GO:0007049 BP 1 cell cycle 1 Q01094,Q14188,Q16254 488 7.59e-03 294 4 2 0.500 0.007 GO:0000785 CC 1 chromatin 1 Q01094,Q16254 488 7.72e-03 2869 4 4 1.000 0.001 GO:0009059 BP 1 macromolecule biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 7.79e-03 298 4 2 0.500 0.007 GO:0019904 MF 1 protein domain specific binding 1 Q14188,Q16254 488 8.37e-03 309 4 2 0.500 0.006 GO:0000981 MF 1 RNA polymerase II transcription factor activity, sequence-specific DNA binding 1 Q14188,Q16254 488 8.40e-03 12 4 1 0.250 0.083 GO:1990841 MF 1 promoter-specific chromatin binding 1 Q16254 488 8.41e-03 2931 4 4 1.000 0.001 GO:0031981 CC 1 nuclear lumen 1 Q14209,Q01094,Q14188,Q16254 488 8.62e-03 1212 4 3 0.750 0.002 GO:0033554 BP 1 cellular response to stress 1 Q01094,Q14188,Q16254 488 9.39e-03 3013 4 4 1.000 0.001 GO:0090304 BP 1 nucleic acid metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 9.97e-03 3058 4 4 1.000 0.001 GO:0010467 BP 1 gene expression 1 Q14209,Q01094,Q14188,Q16254 488 1.04e-02 13 4 1 0.250 0.077 REAC:6804116 rea 1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1 Q01094 488 1.11e-02 357 4 2 0.500 0.006 GO:0044454 CC 1 nuclear chromosome part 1 Q01094,Q16254 488 1.12e-02 218 4 2 0.500 0.009 KEGG:05166 keg 1 HTLV-I infection 1 Q14209,Q01094 488 1.15e-02 3168 4 4 1.000 0.001 GO:0044428 CC 1 nuclear part 1 Q14209,Q01094,Q14188,Q16254 488 1.16e-02 489 4 2 0.500 0.004 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 Q01094,Q14188 488 1.23e-02 505 4 2 0.500 0.004 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 Q01094,Q14188 488 1.28e-02 383 4 2 0.500 0.005 GO:0000228 CC 1 nuclear chromosome 1 Q01094,Q16254 488 1.36e-02 531 4 2 0.500 0.004 HPA:029010_13 hpa 1 placenta; decidual cells[Supportive,High] 1 Q01094,Q14188 488 1.40e-02 540 4 2 0.500 0.004 HPA:018020_13 hpa 1 hippocampus; neuronal cells[Supportive,High] 1 Q01094,Q14188 488 1.41e-02 541 4 2 0.500 0.004 HPA:023020_13 hpa 1 lymph node; non-germinal center cells[Supportive,High] 1 Q01094,Q14188 488 1.43e-02 2 4 1 0.250 0.500 CORUM:5160 cor 1 E2F4-p130 complex 1 Q16254 488 1.43e-02 2 4 1 0.250 0.500 CORUM:5099 cor 1 RB1(hypophosphorylated)-E2F4 complex 1 Q16254 488 1.43e-02 2 4 1 0.250 0.500 CORUM:5143 cor 1 E2F1-Rb complex 1 Q01094 488 1.43e-02 2 4 1 0.250 0.500 CORUM:1250 cor 1 pRB-E2F-1 complex 1 Q01094 488 1.54e-02 22 4 1 0.250 0.045 GO:0048146 BP 1 positive regulation of fibroblast proliferation 1 Q01094 488 1.54e-02 22 4 1 0.250 0.045 GO:0000083 BP 1 regulation of transcription involved in G1/S transition of mitotic cell cycle 1 Q01094 488 1.60e-02 3443 4 4 1.000 0.001 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 1.61e-02 23 4 1 0.250 0.043 GO:0045599 BP 1 negative regulation of fat cell differentiation 1 Q01094 488 1.66e-02 589 4 2 0.500 0.003 HPA:046020_13 hpa 1 tonsil; non-germinal center cells[Supportive,High] 1 Q01094,Q14188 488 1.68e-02 24 4 1 0.250 0.042 GO:0043392 BP 1 negative regulation of DNA binding 1 Q01094 488 1.71e-02 1533 4 3 0.750 0.002 GO:0035556 BP 1 intracellular signal transduction 1 Q01094,Q14188,Q16254 488 1.71e-02 3499 4 4 1.000 0.001 GO:0044249 BP 1 cellular biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 1.75e-02 25 4 1 0.250 0.040 GO:0048255 BP 1 mRNA stabilization 1 Q01094 488 1.75e-02 25 4 1 0.250 0.040 GO:1900740 BP 1 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 Q01094 488 1.75e-02 25 4 1 0.250 0.040 GO:1900739 BP 1 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 Q01094 488 1.76e-02 608 4 2 0.500 0.003 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 Q01094,Q14188 488 1.82e-02 26 4 1 0.250 0.038 GO:0043489 BP 1 RNA stabilization 1 Q01094 488 1.82e-02 3554 4 4 1.000 0.001 GO:0046483 BP 1 heterocycle metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 1.83e-02 3561 4 4 1.000 0.001 GO:0070013 CC 1 intracellular organelle lumen 1 Q14209,Q01094,Q14188,Q16254 488 1.83e-02 3561 4 4 1.000 0.001 GO:0031974 CC 1 membrane-enclosed lumen 1 Q14209,Q01094,Q14188,Q16254 488 1.83e-02 3561 4 4 1.000 0.001 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 1.83e-02 3561 4 4 1.000 0.001 GO:0043233 CC 1 organelle lumen 1 Q14209,Q01094,Q14188,Q16254 488 1.85e-02 3569 4 4 1.000 0.001 GO:1901576 BP 1 organic substance biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 1.89e-02 27 4 1 0.250 0.037 GO:0001844 BP 1 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1 Q01094 488 1.89e-02 27 4 1 0.250 0.037 GO:0051204 BP 1 protein insertion into mitochondrial membrane 1 Q01094 488 1.91e-02 634 4 2 0.500 0.003 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q01094,Q14188 488 1.93e-02 473 4 2 0.500 0.004 GO:0043565 MF 1 sequence-specific DNA binding 1 Q01094,Q16254 488 1.96e-02 28 4 1 0.250 0.036 GO:0098534 BP 1 centriole assembly 1 Q16254 488 1.96e-02 3620 4 4 1.000 0.001 GO:0009058 BP 1 biosynthetic process 1 Q14209,Q01094,Q14188,Q16254 488 2.02e-02 653 4 2 0.500 0.003 HPA:028010_13 hpa 1 parathyroid gland; glandular cells[Supportive,High] 1 Q01094,Q14188 488 2.05e-02 1635 4 3 0.750 0.002 GO:0031325 BP 1 positive regulation of cellular metabolic process 1 Q01094,Q14188,Q16254 488 2.09e-02 1644 4 3 0.750 0.002 GO:0010604 BP 1 positive regulation of macromolecule metabolic process 1 Q01094,Q14188,Q16254 488 2.09e-02 3681 4 4 1.000 0.001 GO:1901360 BP 1 organic cyclic compound metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 2.13e-02 1656 4 3 0.750 0.002 GO:0006355 BP 1 regulation of transcription, DNA-templated 1 Q01094,Q14188,Q16254 488 2.15e-02 3 4 1 0.250 0.333 CORUM:5656 cor 1 CEBPE-E2F1-RB1 complex 1 Q01094 488 2.15e-02 3 4 1 0.250 0.333 CORUM:5144 cor 1 E2F1-p107-cyclinA complex 1 Q01094 488 2.15e-02 3 4 1 0.250 0.333 CORUM:1661 cor 1 E2F4-p107-cyclinA complex 1 Q16254 488 2.15e-02 3 4 1 0.250 0.333 CORUM:3900 cor 1 GABP(gamma)1-E2F1-DP1 complex 1 Q01094 488 2.15e-02 3 4 1 0.250 0.333 CORUM:5159 cor 1 E2F4-p107-cyclinE complex 1 Q16254 488 2.16e-02 1663 4 3 0.750 0.002 GO:1903506 BP 1 regulation of nucleic acid-templated transcription 1 Q01094,Q14188,Q16254 488 2.23e-02 1681 4 3 0.750 0.002 GO:2001141 BP 1 regulation of RNA biosynthetic process 1 Q01094,Q14188,Q16254 488 2.23e-02 32 4 1 0.250 0.031 GO:1901030 BP 1 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 Q01094 488 2.30e-02 33 4 1 0.250 0.030 GO:0051205 BP 1 protein insertion into membrane 1 Q01094 488 2.35e-02 2051 4 3 0.750 0.001 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 Q14209,Q01094,Q14188 488 2.39e-02 713 4 2 0.500 0.003 HPA:006010_13 hpa 1 cerebellum; Purkinje cells[Supportive,High] 1 Q01094,Q14188 488 2.43e-02 325 4 2 0.500 0.006 KEGG:05200 keg 1 Pathways in cancer 1 Q14209,Q01094 488 2.48e-02 1745 4 3 0.750 0.002 GO:0009893 BP 1 positive regulation of metabolic process 1 Q01094,Q14188,Q16254 488 2.52e-02 733 4 2 0.500 0.003 HPA:014010_13 hpa 1 esophagus; squamous epithelial cells[Supportive,High] 1 Q01094,Q14188 488 2.58e-02 37 4 1 0.250 0.027 GO:0048145 BP 1 regulation of fibroblast proliferation 1 Q01094 488 2.60e-02 1775 4 3 0.750 0.002 GO:0051252 BP 1 regulation of RNA metabolic process 1 Q01094,Q14188,Q16254 488 2.65e-02 38 4 1 0.250 0.026 GO:0048144 BP 1 fibroblast proliferation 1 Q01094 488 2.65e-02 38 4 1 0.250 0.026 GO:1901028 BP 1 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 Q01094 488 2.67e-02 755 4 2 0.500 0.003 HPA:012010_12 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Medium] 1 Q01094,Q14188 488 2.72e-02 565 4 2 0.500 0.004 GO:0044427 CC 1 chromosomal part 1 Q01094,Q16254 488 2.77e-02 3948 4 4 1.000 0.001 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 2.80e-02 775 4 2 0.500 0.003 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 Q01094,Q14188 488 2.84e-02 781 4 2 0.500 0.003 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 Q01094,Q14188 488 2.86e-02 4 4 1 0.250 0.250 CORUM:1488 cor 1 DNMT1-RB1-HDAC1-E2F1 complex 1 Q01094 488 3.07e-02 44 4 1 0.250 0.023 GO:0097345 BP 1 mitochondrial outer membrane permeabilization 1 Q01094 488 3.14e-02 45 4 1 0.250 0.022 GO:1902110 BP 1 positive regulation of mitochondrial membrane permeability involved in apoptotic process 1 Q01094 488 3.14e-02 45 4 1 0.250 0.022 GO:1902686 BP 1 mitochondrial outer membrane permeabilization involved in programmed cell death 1 Q01094 488 3.14e-02 609 4 2 0.500 0.003 GO:0005694 CC 1 chromosome 1 Q01094,Q16254 488 3.21e-02 46 4 1 0.250 0.022 GO:0045598 BP 1 regulation of fat cell differentiation 1 Q01094 488 3.21e-02 46 4 1 0.250 0.022 GO:1905710 BP 1 positive regulation of membrane permeability 1 Q01094 488 3.21e-02 46 4 1 0.250 0.022 GO:0035794 BP 1 positive regulation of mitochondrial membrane permeability 1 Q01094 488 3.23e-02 836 4 2 0.500 0.002 HPA:027010_13 hpa 1 pancreas; exocrine glandular cells[Supportive,High] 1 Q01094,Q14188 488 3.24e-02 619 4 2 0.500 0.003 GO:0045892 BP 1 negative regulation of transcription, DNA-templated 1 Q01094,Q14188 488 3.27e-02 1923 4 3 0.750 0.002 GO:2000112 BP 1 regulation of cellular macromolecule biosynthetic process 1 Q01094,Q14188,Q16254 488 3.27e-02 47 4 1 0.250 0.021 GO:1902108 BP 1 regulation of mitochondrial membrane permeability involved in apoptotic process 1 Q01094 488 3.28e-02 623 4 2 0.500 0.003 GO:1903507 BP 1 negative regulation of nucleic acid-templated transcription 1 Q01094,Q14188 488 3.34e-02 48 4 1 0.250 0.021 GO:0051101 BP 1 regulation of DNA binding 1 Q01094 488 3.38e-02 632 4 2 0.500 0.003 GO:1902679 BP 1 negative regulation of RNA biosynthetic process 1 Q01094,Q14188 488 3.42e-02 2342 4 3 0.750 0.001 HPA:027010_03 hpa 1 pancreas; exocrine glandular cells[Uncertain,High] 1 Q01094,Q14188,Q16254 488 3.47e-02 867 4 2 0.500 0.002 HPA:035020_03 hpa 1 skin 1; fibroblasts[Uncertain,High] 1 Q01094,Q14188 488 3.50e-02 871 4 2 0.500 0.002 HPA:018010_12 hpa 1 hippocampus; glial cells[Supportive,Medium] 1 Q01094,Q14188 488 3.54e-02 1976 4 3 0.750 0.002 GO:0010556 BP 1 regulation of macromolecule biosynthetic process 1 Q01094,Q14188,Q16254 488 3.54e-02 877 4 2 0.500 0.002 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 Q01094,Q14188 488 3.55e-02 51 4 1 0.250 0.020 GO:0046902 BP 1 regulation of mitochondrial membrane permeability 1 Q01094 488 3.58e-02 5 4 1 0.250 0.200 CORUM:2975 cor 1 SMAD3-E2F4/5-p107-DP1 complex 1 Q16254 488 3.58e-02 5 4 1 0.250 0.200 CORUM:5118 cor 1 pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) 1 Q16254 488 3.58e-02 5 4 1 0.250 0.200 CORUM:5117 cor 1 pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) 1 Q16254 488 3.63e-02 2392 4 3 0.750 0.001 HPA:020010_02 hpa 1 lateral ventricle; glial cells[Uncertain,Medium] 1 Q14209,Q01094,Q14188 488 3.63e-02 1994 4 3 0.750 0.002 GO:0019219 BP 1 regulation of nucleobase-containing compound metabolic process 1 Q01094,Q14188,Q16254 488 3.69e-02 53 4 1 0.250 0.019 GO:0090559 BP 1 regulation of membrane permeability 1 Q01094 488 3.74e-02 667 4 2 0.500 0.003 GO:0051253 BP 1 negative regulation of RNA metabolic process 1 Q01094,Q14188 488 3.77e-02 4264 4 4 1.000 0.001 GO:0006807 BP 1 nitrogen compound metabolic process 1 Q14209,Q01094,Q14188,Q16254 488 3.87e-02 919 4 2 0.500 0.002 HPA:011010_12 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Medium] 1 Q01094,Q14188 488 3.88e-02 921 4 2 0.500 0.002 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 Q01094,Q14188 488 3.90e-02 2454 4 3 0.750 0.001 HPA:024010_03 hpa 1 nasopharynx; respiratory epithelial cells[Uncertain,High] 1 Q01094,Q14188,Q16254 488 3.93e-02 927 4 2 0.500 0.002 HPA:026010_12 hpa 1 ovary; follicle cells[Supportive,Medium] 1 Q01094,Q14188 488 3.96e-02 930 4 2 0.500 0.002 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 Q01094,Q14188 488 4.02e-02 938 4 2 0.500 0.002 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 Q01094,Q14188 488 4.03e-02 2068 4 3 0.750 0.001 GO:0031326 BP 1 regulation of cellular biosynthetic process 1 Q01094,Q14188,Q16254 488 4.04e-02 2071 4 3 0.750 0.001 GO:0006950 BP 1 response to stress 1 Q01094,Q14188,Q16254 488 4.05e-02 942 4 2 0.500 0.002 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 Q01094,Q14188 488 4.10e-02 4858 4 4 1.000 0.001 HPA:040030_01 hpa 1 soft tissue 2; fibroblasts[Uncertain,Low] 1 Q14209,Q01094,Q14188,Q16254 488 4.15e-02 2090 4 3 0.750 0.001 GO:0009889 BP 1 regulation of biosynthetic process 1 Q01094,Q14188,Q16254 488 4.16e-02 114 4 1 0.250 0.009 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 Q14188 488 4.18e-02 958 4 2 0.500 0.002 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 Q01094,Q14188 488 4.24e-02 1485 4 3 0.750 0.002 REAC:74160 rea 1 Gene Expression 1 Q01094,Q14188,Q16254 488 4.24e-02 965 4 2 0.500 0.002 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 Q01094,Q14188 488 4.24e-02 61 4 1 0.250 0.016 GO:0008630 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage 1 Q01094 488 4.27e-02 969 4 2 0.500 0.002 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 Q01094,Q14188 488 4.29e-02 6 4 1 0.250 0.167 CORUM:1474 cor 1 SMAD3/4-E2F4/5-p107-DP1 complex 1 Q16254 488 4.39e-02 4430 4 4 1.000 0.001 GO:0005634 CC 1 nucleus 1 Q14209,Q01094,Q14188,Q16254 488 4.43e-02 4954 4 4 1.000 0.001 HPA:039030_01 hpa 1 soft tissue 1; fibroblasts[Uncertain,Low] 1 Q14209,Q01094,Q14188,Q16254 488 4.45e-02 64 4 1 0.250 0.016 GO:1905477 BP 1 positive regulation of protein localization to membrane 1 Q01094 488 4.50e-02 2585 4 3 0.750 0.001 HPA:029020_03 hpa 1 placenta; trophoblastic cells[Uncertain,High] 1 Q01094,Q14188,Q16254 488 4.55e-02 1002 4 2 0.500 0.002 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 Q01094,Q14188 488 4.64e-02 2173 4 3 0.750 0.001 GO:0010468 BP 1 regulation of gene expression 1 Q01094,Q14188,Q16254 488 4.72e-02 753 4 2 0.500 0.003 GO:0045934 BP 1 negative regulation of nucleobase-containing compound metabolic process 1 Q01094,Q14188 488 4.75e-02 2192 4 3 0.750 0.001 GO:0051171 BP 1 regulation of nitrogen compound metabolic process 1 Q01094,Q14188,Q16254 488 4.87e-02 765 4 2 0.500 0.003 GO:2000113 BP 1 negative regulation of cellular macromolecule biosynthetic process 1 Q01094,Q14188 488 5.00e-02 2 4 1 0.250 0.500 TF:M04495_1 tf 1 Factor: THRB; motif: NTGACCTNATRAGGTCAN; match class: 1 1 Q14188 488 5.00e-02 60 4 1 0.250 0.017 KEGG:04350 keg 1 TGF-beta signaling pathway 1 Q16254 488 5.00e-02 72 4 1 0.250 0.014 GO:0007006 BP 1 mitochondrial membrane organization 1 Q01094 488 5.00e-02 2 4 1 0.250 0.500 TF:M03984_1 tf 1 Factor: ETV6; motif: CCGGAASCGGAAGTR; match class: 1 1 Q16254 488 5.00e-02 7 4 1 0.250 0.143 CORUM:5596 cor 1 LINC complex, quiescent cells 1 Q16254 488 5.00e-02 1575 4 3 0.750 0.002 REAC:162582 rea 1 Signal Transduction 1 Q01094,Q14188,Q16254 489 1.39e-03 1 2 1 0.500 1.000 GO:0043874 MF 1 acireductone synthase activity 1 Q9UHY7 489 1.96e-03 564 2 2 1.000 0.004 TF:M05509_0 tf 1 Factor: ZAC; motif: KGGGGAAGAA; match class: 0 1 Q9UHY7,Q9P2R3 489 2.05e-03 577 2 2 1.000 0.003 TF:M04064_0 tf 1 Factor: PAX5; motif: NGTCACGCWTSANTGMNY; match class: 0 1 Q9UHY7,Q9P2R3 489 2.78e-03 2 2 1 0.500 0.500 GO:0048549 BP 1 positive regulation of pinocytosis 1 Q9P2R3 489 3.87e-03 6 2 1 0.500 0.167 REAC:1237112 rea 1 Methionine salvage pathway 1 Q9UHY7 489 4.17e-03 3 2 1 0.500 0.333 GO:0032439 BP 1 endosome localization 1 Q9P2R3 489 6.75e-03 43 2 1 0.500 0.023 TF:M05648_0 tf 1 Factor: ZNF883; motif: KGTGGCTGCCTC; match class: 0 1 Q9UHY7 489 6.95e-03 5 2 1 0.500 0.200 GO:0044354 CC 1 macropinosome 1 Q9P2R3 489 6.95e-03 5 2 1 0.500 0.200 GO:0044352 CC 1 pinosome 1 Q9P2R3 489 7.84e-03 50 2 1 0.500 0.020 TF:M06764_0 tf 1 Factor: ZNF228; motif: NCCGCCGAACCC; match class: 0 1 Q9UHY7 489 8.15e-03 52 2 1 0.500 0.019 TF:M04216_1 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 1 1 Q9P2R3 489 8.34e-03 6 2 1 0.500 0.167 GO:0090160 BP 1 Golgi to lysosome transport 1 Q9P2R3 489 8.69e-03 1187 2 2 1.000 0.002 TF:M07223_0 tf 1 Factor: PAX5; motif: NNRNKCAGYSRAGCRTGAC; match class: 0 1 Q9UHY7,Q9P2R3 489 9.25e-03 59 2 1 0.500 0.017 TF:M04228_0 tf 1 Factor: XBP1; motif: WNNGMCACGTCATC; match class: 0 1 Q9UHY7 489 9.56e-03 61 2 1 0.500 0.016 TF:M06332_0 tf 1 Factor: ZNF585A; motif: CACCTGGCTAAC; match class: 0 1 Q9P2R3 489 9.73e-03 7 2 1 0.500 0.143 GO:0048548 BP 1 regulation of pinocytosis 1 Q9P2R3 489 1.00e-02 1276 2 2 1.000 0.002 TF:M05310_0 tf 1 Factor: ZNF688; motif: MTCAKAAGACC; match class: 0 1 Q9UHY7,Q9P2R3 489 1.11e-02 1339 2 2 1.000 0.001 TF:M03925_1 tf 1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 1 Q9UHY7,Q9P2R3 489 1.11e-02 8 2 1 0.500 0.125 GO:0019509 BP 1 L-methionine biosynthetic process from methylthioadenosine 1 Q9UHY7 489 1.25e-02 9 2 1 0.500 0.111 GO:0034058 BP 1 endosomal vesicle fusion 1 Q9P2R3 489 1.36e-02 87 2 1 0.500 0.011 TF:M06603_0 tf 1 Factor: ZNF560; motif: NCSWAKTGCTAC; match class: 0 1 Q9P2R3 489 1.39e-02 10 2 1 0.500 0.100 GO:0071267 BP 1 L-methionine salvage 1 Q9UHY7 489 1.39e-02 10 2 1 0.500 0.100 GO:0043102 BP 1 amino acid salvage 1 Q9UHY7 489 1.39e-02 10 2 1 0.500 0.100 GO:0006896 BP 1 Golgi to vacuole transport 1 Q9P2R3 489 1.53e-02 11 2 1 0.500 0.091 GO:0071265 BP 1 L-methionine biosynthetic process 1 Q9UHY7 489 1.60e-02 102 2 1 0.500 0.010 TF:M04172_0 tf 1 Factor: HEY1; motif: GRCACGTGCC; match class: 0 1 Q9P2R3 489 1.60e-02 102 2 1 0.500 0.010 TF:M04173_0 tf 1 Factor: HEY2; motif: GNCACGTGYN; match class: 0 1 Q9P2R3 489 1.61e-02 25 2 1 0.500 0.040 REAC:1614635 rea 1 Sulfur amino acid metabolism 1 Q9UHY7 489 1.67e-02 1645 2 2 1.000 0.001 TF:M07420_0 tf 1 Factor: HES-1; motif: NCTNGTGN; match class: 0 1 Q9UHY7,Q9P2R3 489 1.87e-02 1739 2 2 1.000 0.001 TF:M07042_1 tf 1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 1 Q9UHY7,Q9P2R3 489 1.95e-02 14 2 1 0.500 0.071 GO:0009086 BP 1 methionine biosynthetic process 1 Q9UHY7 489 2.17e-02 139 2 1 0.500 0.007 TF:M04216_0 tf 1 Factor: MAFG; motif: NWWNTGCTGASTCAGCANWWN; match class: 0 1 Q9P2R3 489 2.22e-02 16 2 1 0.500 0.062 GO:0006907 BP 1 pinocytosis 1 Q9P2R3 489 2.36e-02 17 2 1 0.500 0.059 GO:0000097 BP 1 sulfur amino acid biosynthetic process 1 Q9UHY7 489 2.44e-02 156 2 1 0.500 0.006 TF:M00113_1 tf 1 Factor: CREB; motif: NNGNTGACGTNN; match class: 1 1 Q9UHY7 489 2.70e-02 173 2 1 0.500 0.006 TF:M07374_0 tf 1 Factor: Bach1; motif: GCTGAGTCAYGNT; match class: 0 1 Q9P2R3 489 2.75e-02 176 2 1 0.500 0.006 TF:M07140_1 tf 1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 1 Q9P2R3 489 2.78e-02 20 2 1 0.500 0.050 GO:0030904 CC 1 retromer complex 1 Q9P2R3 489 2.92e-02 21 2 1 0.500 0.048 GO:0006555 BP 1 methionine metabolic process 1 Q9UHY7 489 3.20e-02 23 2 1 0.500 0.043 GO:0009067 BP 1 aspartate family amino acid biosynthetic process 1 Q9UHY7 489 3.24e-02 2290 2 2 1.000 0.001 TF:M01217_0 tf 1 Factor: NUR77; motif: NTGACCTTBN; match class: 0 1 Q9UHY7,Q9P2R3 489 3.24e-02 2290 2 2 1.000 0.001 TF:M07347_0 tf 1 Factor: AhR; motif: NNNKNGCGTGNSNNNNN; match class: 0 1 Q9UHY7,Q9P2R3 489 3.47e-02 223 2 1 0.500 0.004 TF:M06677_0 tf 1 Factor: ZNF285; motif: NGTTCMKAAAGM; match class: 0 1 Q9P2R3 489 3.55e-02 228 2 1 0.500 0.004 TF:M04341_1 tf 1 Factor: HOXA13; motif: CYAATAAAAN; match class: 1 1 Q9UHY7 489 3.78e-02 243 2 1 0.500 0.004 TF:M00233_1 tf 1 Factor: MEF-2A; motif: NNTGTTACTAAAAATAGAAMNN; match class: 1 1 Q9UHY7 489 4.06e-02 261 2 1 0.500 0.004 TF:M00538_0 tf 1 Factor: HTF; motif: NNWWWWNGMCACGTCATYNYWNNN; match class: 0 1 Q9UHY7 489 4.21e-02 271 2 1 0.500 0.004 TF:M05344_0 tf 1 Factor: Egr-2; motif: GCGTGGGCGG; match class: 0 1 Q9UHY7 489 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 Q9UHY7,Q9P2R3 489 4.64e-02 299 2 1 0.500 0.003 TF:M05619_0 tf 1 Factor: ZSCAN5C; motif: NMGTTWAACATG; match class: 0 1 Q9UHY7 489 4.67e-02 301 2 1 0.500 0.003 TF:M03897_0 tf 1 Factor: EGR2; motif: NNMCGCCCACGCANN; match class: 0 1 Q9UHY7 489 4.77e-02 307 2 1 0.500 0.003 TF:M01816_1 tf 1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 1 Q9UHY7 489 4.81e-02 310 2 1 0.500 0.003 TF:M04148_1 tf 1 Factor: TFAP2A; motif: NGCCCYNNGGGCN; match class: 1 1 Q9P2R3 489 4.87e-02 314 2 1 0.500 0.003 TF:M07397_1 tf 1 Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 1 Q9UHY7 489 4.98e-02 272 2 1 0.500 0.004 HPA:040020_12 hpa 1 soft tissue 2; chondrocytes[Supportive,Medium] 1 Q9UHY7 489 5.00e-02 36 2 1 0.500 0.028 GO:0000096 BP 1 sulfur amino acid metabolic process 1 Q9UHY7 489 5.00e-02 43 2 1 0.500 0.023 KEGG:00270 keg 1 Cysteine and methionine metabolism 1 Q9UHY7 489 5.00e-02 78 2 1 0.500 0.013 REAC:351202 rea 1 Metabolism of polyamines 1 Q9UHY7 489 5.00e-02 36 2 1 0.500 0.028 GO:0043094 BP 1 cellular metabolic compound salvage 1 Q9UHY7 490 2.20e-03 14 2 1 0.500 0.071 TF:M06773_0 tf 1 Factor: ZNF490; motif: KGGTGCTARCGC; match class: 0 1 P29590 490 2.50e-03 2 2 1 0.500 0.500 GO:0030578 BP 1 PML body organization 1 P29590 490 5.01e-03 4 2 1 0.500 0.250 GO:0042406 CC 1 extrinsic component of endoplasmic reticulum membrane 1 P29590 490 5.01e-03 4 2 1 0.500 0.250 GO:2000059 BP 1 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 1 P29590 490 6.26e-03 5 2 1 0.500 0.200 GO:0030575 BP 1 nuclear body organization 1 P29590 490 7.69e-03 49 2 1 0.500 0.020 TF:M06768_0 tf 1 Factor: znf443; motif: KGWWGGGGCAGC; match class: 0 1 A6NDN3 490 8.62e-03 55 2 1 0.500 0.018 TF:M06134_0 tf 1 Factor: ZNF812; motif: NGCTMATAAATR; match class: 0 1 P29590 490 9.72e-03 62 2 1 0.500 0.016 TF:M06525_0 tf 1 Factor: ZNF431; motif: NGKTWGGGCAGA; match class: 0 1 P29590 490 1.13e-02 9 2 1 0.500 0.111 GO:0032183 MF 1 SUMO binding 1 P29590 490 1.38e-02 11 2 1 0.500 0.091 GO:1902187 BP 1 negative regulation of viral release from host cell 1 P29590 490 1.53e-02 98 2 1 0.500 0.010 TF:M02219_1 tf 1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 1 A6NDN3 490 1.55e-02 99 2 1 0.500 0.010 TF:M01236_0 tf 1 Factor: ipf1; motif: CATTAATMGG; match class: 0 1 A6NDN3 490 1.63e-02 13 2 1 0.500 0.077 GO:0051457 BP 1 maintenance of protein location in nucleus 1 P29590 490 1.74e-02 111 2 1 0.500 0.009 TF:M06003_0 tf 1 Factor: ZNF257; motif: NTGGWGGGCAKM; match class: 0 1 P29590 490 1.88e-02 120 2 1 0.500 0.008 TF:M04108_1 tf 1 Factor: RUNX2; motif: WAACCGCAA; match class: 1 1 P29590 490 1.88e-02 15 2 1 0.500 0.067 GO:0043153 BP 1 entrainment of circadian clock by photoperiod 1 P29590 490 2.00e-02 16 2 1 0.500 0.062 GO:0009648 BP 1 photoperiodism 1 P29590 490 2.00e-02 16 2 1 0.500 0.062 GO:0032469 BP 1 endoplasmic reticulum calcium ion homeostasis 1 P29590 490 2.10e-02 114 2 1 0.500 0.009 HPA:039040_13 hpa 1 soft tissue 1; peripheral nerve[Supportive,High] 1 P29590 490 2.11e-02 52 2 1 0.500 0.019 KEGG:05221 keg 1 Acute myeloid leukemia 1 P29590 490 2.19e-02 140 2 1 0.500 0.007 TF:M07426_1 tf 1 Factor: Nur77; motif: NNNTGACCTTT; match class: 1 1 P29590 490 2.25e-02 18 2 1 0.500 0.056 GO:0031312 CC 1 extrinsic component of organelle membrane 1 P29590 490 2.25e-02 18 2 1 0.500 0.056 GO:0009649 BP 1 entrainment of circadian clock 1 P29590 490 2.28e-02 30 2 1 0.500 0.033 REAC:6804758 rea 1 Regulation of TP53 Activity through Acetylation 1 P29590 490 2.50e-02 2012 2 2 1.000 0.001 TF:M01014_1 tf 1 Factor: SOX; motif: CTCTTTGTTANGA; match class: 1 1 P29590,A6NDN3 490 2.50e-02 136 2 1 0.500 0.007 HPA:039010_13 hpa 1 soft tissue 1; adipocytes[Supportive,High] 1 P29590 490 2.52e-02 2022 2 2 1.000 0.001 TF:M00141_0 tf 1 Factor: Lyf-1; motif: TTTGGGAGR; match class: 0 1 P29590,A6NDN3 490 2.71e-02 147 2 1 0.500 0.007 HPA:007010_13 hpa 1 cerebral cortex; endothelial cells[Supportive,High] 1 P29590 490 2.72e-02 148 2 1 0.500 0.007 HPA:004010_13 hpa 1 breast; adipocytes[Supportive,High] 1 P29590 490 2.72e-02 2101 2 2 1.000 0.001 TF:M03793_0 tf 1 Factor: IRF-7; motif: TTCNNTTTCCYTT; match class: 0 1 P29590,A6NDN3 490 2.75e-02 22 2 1 0.500 0.045 GO:0072595 BP 1 maintenance of protein localization in organelle 1 P29590 490 2.75e-02 22 2 1 0.500 0.045 GO:2001238 BP 1 positive regulation of extrinsic apoptotic signaling pathway 1 P29590 490 2.88e-02 23 2 1 0.500 0.043 GO:1903051 BP 1 negative regulation of proteolysis involved in cellular protein catabolic process 1 P29590 490 2.94e-02 160 2 1 0.500 0.006 HPA:040010_13 hpa 1 soft tissue 2; adipocytes[Supportive,High] 1 P29590 490 3.13e-02 25 2 1 0.500 0.040 GO:1902186 BP 1 regulation of viral release from host cell 1 P29590 490 3.25e-02 26 2 1 0.500 0.038 GO:0042771 BP 1 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 P29590 490 3.29e-02 2310 2 2 1.000 0.001 TF:M07053_1 tf 1 Factor: P53; motif: NNACAWGCCYN; match class: 1 1 P29590,A6NDN3 490 3.35e-02 2330 2 2 1.000 0.001 TF:M07141_0 tf 1 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR; match class: 0 1 P29590,A6NDN3 490 3.63e-02 29 2 1 0.500 0.034 GO:0035891 BP 1 exit from host cell 1 P29590 490 3.63e-02 29 2 1 0.500 0.034 GO:0035890 BP 1 exit from host 1 P29590 490 3.63e-02 29 2 1 0.500 0.034 GO:0052126 BP 1 movement in host environment 1 P29590 490 3.63e-02 29 2 1 0.500 0.034 GO:0019076 BP 1 viral release from host cell 1 P29590 490 3.63e-02 29 2 1 0.500 0.034 GO:0052192 BP 1 movement in environment of other organism involved in symbiotic interaction 1 P29590 490 3.67e-02 200 2 1 0.500 0.005 HPA:040030_13 hpa 1 soft tissue 2; fibroblasts[Supportive,High] 1 P29590 490 3.75e-02 30 2 1 0.500 0.033 GO:1903363 BP 1 negative regulation of cellular protein catabolic process 1 P29590 490 3.79e-02 2102 2 2 1.000 0.001 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P29590,A6NDN3 490 3.88e-02 31 2 1 0.500 0.032 GO:2000779 BP 1 regulation of double-strand break repair 1 P29590 490 3.98e-02 256 2 1 0.500 0.004 TF:M04624_1 tf 1 Factor: Pax-4; motif: DTTTTCCACCN; match class: 1 1 A6NDN3 490 4.01e-02 258 2 1 0.500 0.004 TF:M06377_0 tf 1 Factor: ZNF773; motif: GGGTGGCCGC; match class: 0 1 P29590 490 4.01e-02 258 2 1 0.500 0.004 TF:M06576_0 tf 1 Factor: ZNF419; motif: GGGTGGCCGC; match class: 0 1 P29590 490 4.05e-02 221 2 1 0.500 0.005 HPA:039030_13 hpa 1 soft tissue 1; fibroblasts[Supportive,High] 1 P29590 490 4.10e-02 2578 2 2 1.000 0.001 TF:M02088_0 tf 1 Factor: E2A; motif: NRMCASCTGCNNN; match class: 0 1 P29590,A6NDN3 490 4.11e-02 264 2 1 0.500 0.004 TF:M00415_1 tf 1 Factor: AREB6; motif: CBGTTTSNN; match class: 1 1 A6NDN3 490 4.13e-02 33 2 1 0.500 0.030 GO:0090398 BP 1 cellular senescence 1 P29590 490 4.54e-02 292 2 1 0.500 0.003 TF:M00687_1 tf 1 Factor: alpha-CP1; motif: CAGCCAATGAG; match class: 1 1 A6NDN3 490 4.55e-02 10 2 1 0.500 0.100 HP:0004836 hp 1 Acute promyelocytic leukemia 1 P29590 490 4.63e-02 2740 2 2 1.000 0.001 TF:M00124_1 tf 1 Factor: Pbx-1b; motif: NNCATCAATCAANNW; match class: 1 1 P29590,A6NDN3 490 4.64e-02 115 2 1 0.500 0.009 KEGG:05202 keg 1 Transcriptional misregulation in cancer 1 P29590 490 4.72e-02 304 2 1 0.500 0.003 TF:M03562_1 tf 1 Factor: RAR-gamma; motif: TGACCTBYNKN; match class: 1 1 P29590 490 4.78e-02 308 2 1 0.500 0.003 TF:M06288_0 tf 1 Factor: ZNF829; motif: NTGKACAYCAGM; match class: 0 1 A6NDN3 490 4.85e-02 265 2 1 0.500 0.004 HPA:039040_03 hpa 1 soft tissue 1; peripheral nerve[Uncertain,High] 1 P29590 490 4.88e-02 39 2 1 0.500 0.026 GO:0016525 BP 1 negative regulation of angiogenesis 1 P29590 490 5.00e-02 124 2 1 0.500 0.008 KEGG:04120 keg 1 Ubiquitin mediated proteolysis 1 P29590 490 5.00e-02 11 2 1 0.500 0.091 HP:0012135 hp 1 Abnormality of cells of the granulocytic lineage 1 P29590 490 5.00e-02 40 2 1 0.500 0.025 GO:0010522 BP 1 regulation of calcium ion transport into cytosol 1 P29590 490 5.00e-02 2 2 1 0.500 0.500 CORUM:1055 cor 1 ZNF198-PML complex 1 P29590 490 5.00e-02 66 2 1 0.500 0.015 REAC:877300 rea 1 Interferon gamma signaling 1 P29590 491 2.02e-26 342 45 25 0.556 0.073 GO:0006397 BP 1 mRNA processing 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q16630,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,O75475,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 5.64e-25 141 45 29 0.644 0.206 CORUM:351 cor 1 Spliceosome 1 P09012,Q9BXP5,P55769,Q92841,Q13243,O94906,P17844,O43143,Q16630,Q13123,O14776,Q05519,P49756,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O15042,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9UHX1,P62304,O75400,O00571 491 2.73e-24 228 45 24 0.533 0.105 REAC:72203 rea 1 Processing of Capped Intron-Containing Pre-mRNA 1 P12270,P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,P49792,O15042,Q53GS9,O95400,Q9BUQ8,Q9UHX1,P62304,O75400 491 3.91e-24 265 45 22 0.489 0.083 GO:0000377 BP 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O75475,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 3.91e-24 265 45 22 0.489 0.083 GO:0000398 BP 1 mRNA splicing, via spliceosome 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O75475,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 5.47e-24 269 45 22 0.489 0.082 GO:0000375 BP 1 RNA splicing, via transesterification reactions 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O75475,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 6.67e-24 173 45 22 0.489 0.127 REAC:72163 rea 1 mRNA Splicing - Major Pathway 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O15042,Q53GS9,O95400,Q9BUQ8,Q9UHX1,P62304,O75400 491 1.07e-23 326 45 23 0.511 0.071 GO:0008380 BP 1 RNA splicing 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 1.65e-23 180 45 22 0.489 0.122 REAC:72172 rea 1 mRNA Splicing 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q05519,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O15042,Q53GS9,O95400,Q9BUQ8,Q9UHX1,P62304,O75400 491 7.89e-22 522 45 25 0.556 0.048 GO:0016071 BP 1 mRNA metabolic process 1 P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q16630,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,O75475,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 1.42e-20 752 45 27 0.600 0.036 GO:0006396 BP 1 RNA processing 1 P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,P17844,O43143,Q16630,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,P62304,O75400 491 5.10e-20 3168 45 42 0.933 0.013 GO:0044428 CC 1 nuclear part 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 9.26e-20 1118 45 30 0.667 0.027 GO:0044822 MF 1 poly(A) RNA binding 1 P12270,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,O14776,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q08211,Q09161,Q08945,O15042,O75475,Q9BUQ8,Q9P258,Q9UHX1,O75400,O00571 491 1.27e-19 2529 45 39 0.867 0.015 GO:0005654 CC 1 nucleoplasm 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 9.39e-19 1336 45 31 0.689 0.023 GO:0003723 MF 1 RNA binding 1 P12270,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,O14776,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9BUQ8,Q9P258,Q9UHX1,O75400,O00571 491 1.60e-18 2931 45 40 0.889 0.014 GO:0031981 CC 1 nuclear lumen 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 3.97e-18 128 45 19 0.422 0.148 KEGG:03040 keg 1 Spliceosome 1 P09012,P52272,P55769,Q13243,O94906,P17844,O43143,O14776,P49756,P09234,P62316,Q09161,P62306,O15042,Q53GS9,Q9BUQ8,Q9UHX1,P62304,O75400 491 3.47e-16 781 45 24 0.533 0.031 HPA:040010_12 hpa 1 soft tissue 2; adipocytes[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 4.93e-16 2136 45 34 0.756 0.016 GO:0003676 MF 1 nucleic acid binding 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9BUQ8,Q9P258,Q9UHX1,O75400,O00571 491 7.80e-16 147 45 14 0.311 0.095 GO:0005681 CC 1 spliceosomal complex 1 P09012,P52272,P55769,O94906,P17844,O43143,P49756,P09234,P62316,Q8IYB3,P62306,Q9BUQ8,P62304,O75400 491 1.44e-15 3013 45 38 0.844 0.013 GO:0090304 BP 1 nucleic acid metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 1.90e-15 4430 45 43 0.956 0.010 GO:0005634 CC 1 nucleus 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373,O00571 491 2.42e-15 2627 45 36 0.800 0.014 GO:0016070 BP 1 RNA metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,P17844,O43143,Q16630,Q14839,O14776,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 2.80e-15 3561 45 40 0.889 0.011 GO:0043233 CC 1 organelle lumen 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 2.80e-15 3561 45 40 0.889 0.011 GO:0031974 CC 1 membrane-enclosed lumen 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 2.80e-15 3561 45 40 0.889 0.011 GO:0070013 CC 1 intracellular organelle lumen 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373 491 7.29e-15 1623 45 30 0.667 0.018 HPA:026020_11 hpa 1 ovary; ovarian stroma cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 9.68e-15 1787 45 31 0.689 0.017 HPA:007030_12 hpa 1 cerebral cortex; neuronal cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 2.44e-14 54 45 10 0.222 0.185 GO:0097525 CC 1 spliceosomal snRNP complex 1 P09012,P55769,O94906,P09234,P62316,P62306,O95400,Q9BUQ8,P62304,O75400 491 9.00e-14 61 45 10 0.222 0.164 GO:0030532 CC 1 small nuclear ribonucleoprotein complex 1 P09012,P55769,O94906,P09234,P62316,P62306,O95400,Q9BUQ8,P62304,O75400 491 9.88e-14 2102 45 32 0.711 0.015 HPA:044020_12 hpa 1 testis; cells in seminiferous ducts[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.10e-13 2110 45 32 0.711 0.015 HPA:047010_12 hpa 1 urinary bladder; urothelial cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.50e-13 1521 45 28 0.622 0.018 HPA:020020_12 hpa 1 lateral ventricle; neuronal cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.67e-13 3443 45 38 0.844 0.011 GO:0006139 BP 1 nucleobase-containing compound metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 2.00e-13 1274 45 26 0.578 0.020 HPA:006030_12 hpa 1 cerebellum; cells in molecular layer[Supportive,Medium] 1 P12270,O95983,P09012,P52272,O94906,Q14974,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 2.03e-13 1989 45 31 0.689 0.016 HPA:041010_11 hpa 1 spleen; cells in red pulp[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 2.06e-13 1990 45 31 0.689 0.016 HPA:013010_12 hpa 1 epididymis; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 2.20e-13 1408 45 27 0.600 0.019 HPA:023010_12 hpa 1 lymph node; germinal center cells[Supportive,Medium] 1 P12270,P09012,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.79e-13 2612 45 34 0.756 0.013 GO:1901363 MF 1 heterocyclic compound binding 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9BUQ8,Q9P258,Q9UHX1,O75400,O00571 491 3.18e-13 2188 45 32 0.711 0.015 HPA:018020_11 hpa 1 hippocampus; neuronal cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.31e-13 2191 45 32 0.711 0.015 HPA:046020_11 hpa 1 tonsil; non-germinal center cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.71e-13 1576 45 28 0.622 0.018 HPA:018020_12 hpa 1 hippocampus; neuronal cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1 491 3.86e-13 3058 45 36 0.800 0.012 GO:0010467 BP 1 gene expression 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,P17844,O43143,Q16630,Q14839,O14776,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 4.20e-13 2209 45 32 0.711 0.014 HPA:031010_12 hpa 1 rectum; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.54e-13 2215 45 32 0.711 0.014 HPA:025010_11 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.68e-13 2049 45 31 0.689 0.015 HPA:004030_11 hpa 1 breast; myoepithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 4.91e-13 2660 45 34 0.756 0.013 GO:0097159 MF 1 organic cyclic compound binding 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q08211,Q09161,P62306,Q08945,O15042,O75475,Q9BUQ8,Q9P258,Q9UHX1,O75400,O00571 491 5.11e-13 3554 45 38 0.844 0.011 GO:0046483 BP 1 heterocycle metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 5.48e-13 3561 45 38 0.844 0.011 GO:0006725 BP 1 cellular aromatic compound metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 6.26e-13 1909 45 30 0.667 0.016 HPA:006030_11 hpa 1 cerebellum; cells in molecular layer[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 6.34e-13 1470 45 27 0.600 0.018 HPA:004030_12 hpa 1 breast; myoepithelial cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 6.95e-13 775 45 21 0.467 0.027 HPA:007030_13 hpa 1 cerebral cortex; neuronal cells[Supportive,High] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4 491 8.38e-13 599 45 19 0.422 0.032 GO:0030529 CC 1 intracellular ribonucleoprotein complex 1 P09012,P52272,P55769,O94906,P17844,O43143,Q16630,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O95400,Q9BUQ8,P62304,O75400,O00571 491 8.63e-13 600 45 19 0.422 0.032 GO:1990904 CC 1 ribonucleoprotein complex 1 P09012,P52272,P55769,O94906,P17844,O43143,Q16630,P49756,P09234,P62316,Q8IYB3,Q08211,Q09161,P62306,O95400,Q9BUQ8,P62304,O75400,O00571 491 8.67e-13 1932 45 30 0.667 0.016 HPA:006020_11 hpa 1 cerebellum; cells in granular layer[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 8.79e-13 1933 45 30 0.667 0.016 HPA:038010_11 hpa 1 smooth muscle; smooth muscle cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 9.72e-13 2274 45 32 0.711 0.014 HPA:007030_11 hpa 1 cerebral cortex; neuronal cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.11e-12 1950 45 30 0.667 0.015 HPA:045010_12 hpa 1 thyroid gland; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.16e-12 1797 45 29 0.644 0.016 HPA:012020_12 hpa 1 endometrium 2; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.23e-12 1247 45 25 0.556 0.020 HPA:035010_12 hpa 1 skin 1; Langerhans[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 1.27e-12 2295 45 32 0.711 0.014 HPA:004020_11 hpa 1 breast; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.46e-12 1813 45 29 0.644 0.016 HPA:046030_12 hpa 1 tonsil; squamous epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.49e-12 2308 45 32 0.711 0.014 HPA:022010_11 hpa 1 lung; macrophages[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.56e-12 2139 45 31 0.689 0.014 HPA:020020_11 hpa 1 lateral ventricle; neuronal cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.57e-12 1818 45 29 0.644 0.016 HPA:014010_12 hpa 1 esophagus; squamous epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.75e-12 3681 45 38 0.844 0.010 GO:1901360 BP 1 organic cyclic compound metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 1.83e-12 1986 45 30 0.667 0.015 HPA:023010_11 hpa 1 lymph node; germinal center cells[Supportive,Low] 1 P12270,O95983,P09012,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.87e-12 2153 45 31 0.689 0.014 HPA:043010_12 hpa 1 stomach 2; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.15e-12 1998 45 30 0.667 0.015 HPA:029020_12 hpa 1 placenta; trophoblastic cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 2.27e-12 2342 45 32 0.711 0.014 HPA:045010_11 hpa 1 thyroid gland; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.34e-12 930 45 22 0.489 0.024 HPA:044020_13 hpa 1 testis; cells in seminiferous ducts[Supportive,High] 1 P12270,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 2.51e-12 2176 45 31 0.689 0.014 HPA:023020_11 hpa 1 lymph node; non-germinal center cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.74e-12 1857 45 29 0.644 0.016 HPA:004020_12 hpa 1 breast; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.79e-12 938 45 22 0.489 0.023 HPA:024010_13 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 3.05e-12 2366 45 32 0.711 0.014 HPA:029020_11 hpa 1 placenta; trophoblastic cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.83e-12 2385 45 32 0.711 0.013 HPA:013010_11 hpa 1 epididymis; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.91e-12 2043 45 30 0.667 0.015 HPA:001010_12 hpa 1 adrenal gland; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 3.93e-12 1883 45 29 0.644 0.015 HPA:007020_11 hpa 1 cerebral cortex; glial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 4.23e-12 1589 45 27 0.600 0.017 HPA:046010_12 hpa 1 tonsil; germinal center cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.32e-12 2395 45 32 0.711 0.013 HPA:044010_11 hpa 1 testis; Leydig cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.42e-12 2397 45 32 0.711 0.013 HPA:002010_11 hpa 1 appendix; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 5.61e-12 2417 45 32 0.711 0.013 HPA:024010_11 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 5.77e-12 5787 45 44 0.978 0.008 GO:0044446 CC 1 intracellular organelle part 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9P258,Q9UHX1,P62304,O75400,O95373,O00571 491 6.17e-12 2425 45 32 0.711 0.013 HPA:001010_11 hpa 1 adrenal gland; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.22e-12 1091 45 23 0.511 0.021 HPA:038010_12 hpa 1 smooth muscle; smooth muscle cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 6.47e-12 2429 45 32 0.711 0.013 HPA:015010_11 hpa 1 fallopian tube; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.82e-12 173 45 12 0.267 0.069 GO:0022618 BP 1 ribonucleoprotein complex assembly 1 Q13243,O94906,P09234,P62316,P62306,O75475,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O00571 491 6.84e-12 2086 45 30 0.667 0.014 HPA:024010_12 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1 491 6.94e-12 2435 45 32 0.711 0.013 HPA:047010_11 hpa 1 urinary bladder; urothelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.96e-12 1622 45 27 0.600 0.017 HPA:011010_11 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 7.65e-12 1932 45 29 0.644 0.015 HPA:044010_12 hpa 1 testis; Leydig cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 8.02e-12 1780 45 28 0.622 0.016 HPA:007010_11 hpa 1 cerebral cortex; endothelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 8.13e-12 2270 45 31 0.689 0.014 HPA:003010_11 hpa 1 bone marrow; hematopoietic cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.23e-12 2271 45 31 0.689 0.014 HPA:014010_11 hpa 1 esophagus; squamous epithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.25e-12 1782 45 28 0.622 0.016 HPA:036010_12 hpa 1 skin 2; epidermal cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 8.30e-12 1492 45 26 0.578 0.017 HPA:012010_11 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,O75400 491 8.53e-12 2274 45 31 0.689 0.014 HPA:046030_11 hpa 1 tonsil; squamous epithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 9.07e-12 2458 45 32 0.711 0.013 HPA:042010_11 hpa 1 stomach 1; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.03e-11 2469 45 32 0.711 0.013 HPA:043010_11 hpa 1 stomach 2; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.04e-11 2290 45 31 0.689 0.014 HPA:033010_11 hpa 1 seminal vesicle; glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.04e-11 2119 45 30 0.667 0.014 HPA:005010_12 hpa 1 bronchus; respiratory epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.05e-11 1002 45 22 0.489 0.022 HPA:039030_12 hpa 1 soft tissue 1; fibroblasts[Supportive,Medium] 1 P12270,P09012,P52272,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 1.07e-11 2472 45 32 0.711 0.013 HPA:016010_11 hpa 1 gallbladder; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.12e-11 5877 45 44 0.978 0.007 GO:0044422 CC 1 organelle part 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9P258,Q9UHX1,P62304,O75400,O95373,O00571 491 1.13e-11 2477 45 32 0.711 0.013 HPA:031010_11 hpa 1 rectum; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.20e-11 1659 45 27 0.600 0.016 HPA:025010_12 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.25e-11 182 45 12 0.267 0.066 GO:0071826 BP 1 ribonucleoprotein complex subunit organization 1 Q13243,O94906,P09234,P62316,P62306,O75475,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O00571 491 1.34e-11 2139 45 30 0.667 0.014 HPA:017010_11 hpa 1 heart muscle; myocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.39e-11 2495 45 32 0.711 0.013 HPA:037010_11 hpa 1 small intestine; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.40e-11 1820 45 28 0.622 0.015 HPA:011020_12 hpa 1 endometrium 1; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 1.41e-11 2496 45 32 0.711 0.013 HPA:010010_11 hpa 1 duodenum; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.50e-11 1825 45 28 0.622 0.015 HPA:035010_11 hpa 1 skin 1; Langerhans[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.55e-11 2151 45 30 0.667 0.014 HPA:046010_11 hpa 1 tonsil; germinal center cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.56e-11 2505 45 32 0.711 0.013 HPA:044020_11 hpa 1 testis; cells in seminiferous ducts[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.57e-11 1396 45 25 0.556 0.018 HPA:008020_12 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,Q07666,P09234,P62316,Q6P1J9,Q08211,Q09161,P49792,O75475,O95400,Q9UHX1,O75400 491 1.61e-11 1535 45 26 0.578 0.017 HPA:035030_12 hpa 1 skin 1; keratinocytes[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1 491 1.63e-11 2328 45 31 0.689 0.013 HPA:027010_11 hpa 1 pancreas; exocrine glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.71e-11 2159 45 30 0.667 0.014 HPA:042010_12 hpa 1 stomach 1; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.02e-11 3948 45 38 0.844 0.010 GO:0034641 BP 1 cellular nitrogen compound metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 2.30e-11 1559 45 26 0.578 0.017 HPA:023020_12 hpa 1 lymph node; non-germinal center cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O75400 491 2.50e-11 2547 45 32 0.711 0.013 HPA:019020_11 hpa 1 kidney; cells in tubules[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.68e-11 46 45 8 0.178 0.174 GO:0000245 BP 1 spliceosomal complex assembly 1 Q13243,O94906,P09234,P62316,O75475,Q53GS9,Q9BUQ8,P62304 491 2.72e-11 2197 45 30 0.667 0.014 HPA:035030_11 hpa 1 skin 1; keratinocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.82e-11 730 45 19 0.422 0.026 HPA:039010_12 hpa 1 soft tissue 1; adipocytes[Supportive,Medium] 1 O95983,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q13123,P20700,Q05519,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 2.89e-11 2202 45 30 0.667 0.014 HPA:019020_12 hpa 1 kidney; cells in tubules[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.13e-11 1880 45 28 0.622 0.015 HPA:019010_11 hpa 1 kidney; cells in glomeruli[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 3.22e-11 1308 45 24 0.533 0.018 HPA:006020_12 hpa 1 cerebellum; cells in granular layer[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,P17844,Q16630,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 3.90e-11 2227 45 30 0.667 0.013 HPA:010010_12 hpa 1 duodenum; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 3.90e-11 2227 45 30 0.667 0.013 HPA:016010_12 hpa 1 gallbladder; glandular cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.19e-11 1600 45 26 0.578 0.016 HPA:003010_12 hpa 1 bone marrow; hematopoietic cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400 491 4.20e-11 1459 45 25 0.556 0.017 HPA:040010_11 hpa 1 soft tissue 2; adipocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 4.28e-11 1904 45 28 0.622 0.015 HPA:022020_11 hpa 1 lung; pneumocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 4.52e-11 324 45 14 0.311 0.043 GO:0051169 BP 1 nuclear transport 1 P12270,Q13243,Q14974,Q05519,Q07666,P62316,P62826,Q8IYB3,Q09161,P62306,P49792,O75475,P62304,O95373 491 4.57e-11 2071 45 29 0.644 0.014 HPA:028010_11 hpa 1 parathyroid gland; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 4.62e-11 2072 45 29 0.644 0.014 HPA:035040_11 hpa 1 skin 1; melanocytes[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 5.30e-11 1765 45 27 0.600 0.015 HPA:041020_11 hpa 1 spleen; cells in white pulp[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 5.31e-11 484 45 16 0.356 0.033 HPA:020020_13 hpa 1 lateral ventricle; neuronal cells[Supportive,High] 1 P12270,P09012,P52272,Q14974,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,Q2TAY7,P62316,Q8IYB3,Q08211,O75475,O75400 491 5.91e-11 2092 45 29 0.644 0.014 HPA:015010_12 hpa 1 fallopian tube; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.70e-11 1100 45 22 0.489 0.020 HPA:007020_12 hpa 1 cerebral cortex; glial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,P17844,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 6.93e-11 2276 45 30 0.667 0.013 HPA:012020_11 hpa 1 endometrium 2; glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.06e-11 2456 45 31 0.689 0.013 HPA:005010_11 hpa 1 bronchus; respiratory epithelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.18e-11 2279 45 30 0.667 0.013 HPA:032010_11 hpa 1 salivary gland; glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 7.21e-11 1788 45 27 0.600 0.015 HPA:020010_11 hpa 1 lateral ventricle; glial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 7.35e-11 2281 45 30 0.667 0.013 HPA:030010_11 hpa 1 prostate; glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.47e-11 877 45 20 0.444 0.023 HPA:026020_12 hpa 1 ovary; ovarian stroma cells[Supportive,Medium] 1 P09012,Q9BXP5,P52272,Q92841,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4 491 8.94e-11 1372 45 24 0.533 0.017 HPA:009030_12 hpa 1 colon; peripheral nerve/ganglion[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q14839,Q13123,Q05519,P49756,Q07666,Q2TAY7,P09234,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,O75400 491 9.35e-11 2130 45 29 0.644 0.014 HPA:048010_11 hpa 1 vagina; squamous epithelial cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.02e-10 2310 45 30 0.667 0.013 HPA:036010_11 hpa 1 skin 2; epidermal cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.12e-10 1670 45 26 0.578 0.016 HPA:006010_12 hpa 1 cerebellum; Purkinje cells[Supportive,Medium] 1 P12270,P09012,P52272,O94906,Q14974,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 1.16e-10 1485 45 30 0.667 0.020 REAC:74160 rea 1 Gene Expression 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q13243,O94906,P17844,O43143,Q14839,Q05519,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9UHX1,P62304,O75400 491 1.23e-10 17 45 6 0.133 0.353 GO:0005685 CC 1 U1 snRNP 1 P09012,P09234,P62316,P62306,P62304,O75400 491 1.24e-10 902 45 20 0.444 0.022 HPA:047010_13 hpa 1 urinary bladder; urothelial cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q92841,O94906,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,Q9NYV4,O75400 491 1.24e-10 2154 45 29 0.644 0.013 HPA:006010_11 hpa 1 cerebellum; Purkinje cells[Supportive,Low] 1 P12270,O95983,P09012,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.29e-10 1396 45 24 0.533 0.017 HPA:009010_12 hpa 1 colon; endothelial cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P09234,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 1.46e-10 2168 45 29 0.644 0.013 HPA:009020_12 hpa 1 colon; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.74e-10 2183 45 29 0.644 0.013 HPA:037010_12 hpa 1 small intestine; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.78e-10 1704 45 26 0.578 0.015 HPA:018010_11 hpa 1 hippocampus; glial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 1.83e-10 1419 45 24 0.533 0.017 HPA:039010_11 hpa 1 soft tissue 1; adipocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 1.91e-10 1863 45 27 0.600 0.014 HPA:033010_12 hpa 1 seminal vesicle; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 1.92e-10 2024 45 28 0.622 0.014 HPA:009010_11 hpa 1 colon; endothelial cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 1.97e-10 2026 45 28 0.622 0.014 HPA:034010_11 hpa 1 skeletal muscle; myocytes[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 2.25e-10 1574 45 25 0.556 0.016 HPA:008010_12 hpa 1 cervix, uterine; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 2.30e-10 2039 45 28 0.622 0.014 HPA:027020_11 hpa 1 pancreas; islets of Langerhans[Supportive,Low] 1 P12270,P09012,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 2.52e-10 1885 45 27 0.600 0.014 HPA:009030_11 hpa 1 colon; peripheral nerve/ganglion[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 2.61e-10 1179 45 22 0.489 0.019 HPA:022020_12 hpa 1 lung; pneumocytes[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,O75475,Q9NYV4,Q9UHX1 491 2.66e-10 2051 45 28 0.622 0.014 HPA:040010_02 hpa 1 soft tissue 2; adipocytes[Uncertain,Medium] 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q14974,P17844,Q16630,Q14839,Q13123,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O15042,O75475,Q9NYV4,Q9BUQ8,Q9UHX1,O00571 491 2.79e-10 2055 45 28 0.622 0.014 HPA:008010_11 hpa 1 cervix, uterine; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 2.86e-10 4264 45 38 0.844 0.009 GO:0006807 BP 1 nitrogen compound metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 3.02e-10 1453 45 24 0.533 0.017 HPA:027020_12 hpa 1 pancreas; islets of Langerhans[Supportive,Medium] 1 P12270,P09012,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 3.52e-10 1756 45 26 0.578 0.015 HPA:032010_12 hpa 1 salivary gland; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 3.67e-10 958 45 20 0.444 0.021 HPA:040030_12 hpa 1 soft tissue 2; fibroblasts[Supportive,Medium] 1 P12270,P09012,P52272,O94906,P17844,Q16630,Q13123,P20700,O14776,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 4.28e-10 1621 45 25 0.556 0.015 HPA:039030_11 hpa 1 soft tissue 1; fibroblasts[Supportive,Low] 1 P12270,P09012,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 4.98e-10 2454 45 30 0.667 0.012 HPA:009020_11 hpa 1 colon; glandular cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 5.15e-10 564 45 16 0.356 0.028 HPA:025010_13 hpa 1 oral mucosa; squamous epithelial cells[Supportive,High] 1 P12270,P09012,Q9BXP5,P52272,O94906,P17844,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P62316,Q8IYB3,Q6P1J9,Q9NYV4 491 5.57e-10 2286 45 29 0.644 0.013 HPA:011020_11 hpa 1 endometrium 1; glandular cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1,O75400 491 5.67e-10 318 45 13 0.289 0.041 GO:0006913 BP 1 nucleocytoplasmic transport 1 P12270,Q13243,Q14974,Q05519,Q07666,P62316,P62826,Q8IYB3,Q09161,P62306,P49792,P62304,O95373 491 5.81e-10 1499 45 24 0.533 0.016 HPA:035040_12 hpa 1 skin 1; melanocytes[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,O75475,Q9NYV4,O95400,Q9UHX1 491 6.14e-10 394 45 14 0.311 0.036 GO:0022613 BP 1 ribonucleoprotein complex biogenesis 1 P55769,Q13243,O94906,P09234,P62316,P62826,P62306,O75475,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O00571 491 6.40e-10 1803 45 26 0.578 0.014 HPA:035020_11 hpa 1 skin 1; fibroblasts[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 7.06e-10 1513 45 24 0.533 0.016 HPA:048010_12 hpa 1 vagina; squamous epithelial cells[Supportive,Medium] 1 P12270,Q9BXP5,P52272,O94906,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 9.63e-10 1996 45 27 0.600 0.014 HPA:002020_11 hpa 1 appendix; lymphoid tissue[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.13e-09 505 45 15 0.333 0.030 HPA:048010_13 hpa 1 vagina; squamous epithelial cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,Q8IYB3,Q08211,Q09161,Q9NYV4,O75400 491 1.31e-09 1707 45 25 0.556 0.015 HPA:022010_12 hpa 1 lung; macrophages[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,O75475,Q9NYV4,Q9UHX1,O75400 491 1.52e-09 158 45 10 0.222 0.063 GO:0006403 BP 1 RNA localization 1 P12270,Q13243,O94906,Q05519,Q07666,P62826,Q8IYB3,Q09161,P49792,Q9Y265 491 1.55e-09 608 45 16 0.356 0.026 HPA:039040_12 hpa 1 soft tissue 1; peripheral nerve[Supportive,Medium] 1 P09012,P52272,Q14974,P17844,Q16630,Q14839,P20700,Q05519,Q07666,P09234,P62316,Q6P1J9,Q08211,Q09161,O75475,Q9NYV4 491 1.96e-09 1589 45 24 0.533 0.015 HPA:046020_12 hpa 1 tonsil; non-germinal center cells[Supportive,Medium] 1 P12270,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O75400 491 2.00e-09 2060 45 27 0.600 0.013 HPA:021020_11 hpa 1 liver; hepatocytes[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 2.50e-09 369 45 13 0.289 0.035 HPA:009030_13 hpa 1 colon; peripheral nerve/ganglion[Supportive,High] 1 P12270,O95983,Q9BXP5,P52272,O94906,Q14839,Q13123,Q07666,P09234,Q08211,Q09161,O75475,Q9NYV4 491 2.64e-09 537 45 15 0.333 0.028 HPA:008010_13 hpa 1 cervix, uterine; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,P17844,Q16630,Q14839,P20700,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,Q9NYV4 491 2.66e-09 631 45 16 0.356 0.025 HPA:003010_13 hpa 1 bone marrow; hematopoietic cells[Supportive,High] 1 P12270,O95983,Q9BXP5,P52272,P17844,Q16630,Q14839,P20700,P52701,Q05519,P49756,P62316,Q6P1J9,Q08211,Q09161,Q9NYV4 491 2.74e-09 1924 45 26 0.578 0.014 HPA:027010_12 hpa 1 pancreas; exocrine glandular cells[Supportive,Medium] 1 P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9UHX1,O75400 491 2.97e-09 1337 45 22 0.489 0.016 HPA:004010_11 hpa 1 breast; adipocytes[Supportive,Low] 1 P12270,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 3.37e-09 965 45 19 0.422 0.020 HPA:029020_13 hpa 1 placenta; trophoblastic cells[Supportive,High] 1 P12270,O95983,Q9BXP5,P52272,P17844,Q16630,Q14839,P20700,Q05519,P49756,Q07666,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4 491 3.61e-09 969 45 19 0.422 0.020 HPA:020010_12 hpa 1 lateral ventricle; glial cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,P17844,Q16630,Q14839,P20700,Q05519,P49756,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4 491 4.11e-09 1360 45 22 0.489 0.016 HPA:002020_12 hpa 1 appendix; lymphoid tissue[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,Q07666,P09234,P62316,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265 491 4.21e-09 1802 45 25 0.556 0.014 HPA:029010_11 hpa 1 placenta; decidual cells[Supportive,Low] 1 P12270,O95983,P09012,Q9BXP5,Q92841,Q14974,P17844,Q16630,Q14839,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,Q8IYB3,Q6P1J9,Q09161,P49792,O75475,O95400,Q9Y265,Q9UHX1 491 4.85e-09 1974 45 26 0.578 0.013 HPA:008020_11 hpa 1 cervix, uterine; squamous epithelial cells[Supportive,Low] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,Q07666,P09234,P62316,Q6P1J9,Q08211,Q09161,P49792,O75475,O95400,Q9UHX1,O75400 491 4.88e-09 658 45 16 0.356 0.024 HPA:004010_12 hpa 1 breast; adipocytes[Supportive,Medium] 1 P12270,Q9BXP5,P52272,Q14974,Q16630,Q14839,Q13123,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,P49792,O75475,Q9NYV4,Q9UHX1 491 5.22e-09 1242 45 21 0.467 0.017 HPA:035020_12 hpa 1 skin 1; fibroblasts[Supportive,Medium] 1 P09012,Q9BXP5,P52272,Q92841,O94906,P17844,Q16630,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,P49792,O75475,Q9NYV4,O95400,Q9UHX1 491 5.86e-09 88 45 8 0.178 0.091 GO:0071013 CC 1 catalytic step 2 spliceosome 1 P52272,O94906,P17844,P62316,Q8IYB3,P62306,Q9BUQ8,P62304 491 7.10e-09 1133 45 20 0.444 0.018 HPA:031010_13 hpa 1 rectum; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q92841,O94906,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,Q9NYV4,O75400 491 7.33e-09 1135 45 20 0.444 0.018 HPA:019010_12 hpa 1 kidney; cells in glomeruli[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,O94906,Q16630,Q14839,Q13123,P20700,O14776,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q09161,O75475,Q9NYV4 491 7.42e-09 1403 45 22 0.489 0.016 HPA:029010_12 hpa 1 placenta; decidual cells[Supportive,Medium] 1 P12270,O95983,P09012,Q9BXP5,Q92841,Q14974,P17844,Q16630,Q14839,P20700,O14776,Q05519,P49756,Q07666,Q2TAY7,P09234,Q8IYB3,Q6P1J9,Q09161,P49792,O75475,Q9UHX1 491 9.20e-09 906 45 18 0.400 0.020 HPA:005010_13 hpa 1 bronchus; respiratory epithelial cells[Supportive,High] 1 P12270,Q9BXP5,P52272,O94906,P17844,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P62316,Q8IYB3,Q6P1J9,Q09161,P49792,Q9NYV4,Q9Y265 491 1.13e-08 2051 45 26 0.578 0.013 HPA:002010_12 hpa 1 appendix; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q92841,O94906,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 1.25e-08 16 45 5 0.111 0.312 GO:0005682 CC 1 U5 snRNP 1 O94906,P62316,O95400,Q9BUQ8,P62304 491 1.32e-08 1307 45 21 0.467 0.016 HPA:034010_12 hpa 1 skeletal muscle; myocytes[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,P17844,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O75400 491 1.70e-08 942 45 18 0.400 0.019 HPA:007010_12 hpa 1 cerebral cortex; endothelial cells[Supportive,Medium] 1 O95983,P09012,Q9BXP5,P52272,Q14974,P17844,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P09234,P62316,Q09161,O75475,Q9UHX1 491 1.83e-08 1619 45 23 0.511 0.014 HPA:021010_11 hpa 1 liver; bile duct cells[Supportive,Low] 1 P12270,P09012,P52272,Q14974,P17844,Q16630,Q13123,P20700,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,Q9UHX1 491 1.84e-08 36 45 6 0.133 0.167 GO:0000387 BP 1 spliceosomal snRNP assembly 1 O94906,P09234,P62316,P62306,O95400,P62304 491 1.90e-08 1622 45 23 0.511 0.014 HPA:028010_12 hpa 1 parathyroid gland; glandular cells[Supportive,Medium] 1 P12270,P09012,Q9BXP5,P52272,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,P49792,O75475,Q9NYV4,Q9UHX1,O75400 491 2.12e-08 1078 45 19 0.422 0.018 HPA:009020_13 hpa 1 colon; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,O94906,Q16630,Q14839,Q13123,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,Q9NYV4,O75400 491 2.52e-08 634 45 15 0.333 0.024 HPA:036010_13 hpa 1 skin 2; epidermal cells[Supportive,High] 1 Q9BXP5,P52272,O94906,Q16630,Q14839,P20700,Q05519,Q07666,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,Q9NYV4,O75400 491 2.59e-08 1221 45 20 0.444 0.016 HPA:039040_11 hpa 1 soft tissue 1; peripheral nerve[Supportive,Low] 1 P12270,P09012,P52272,Q14974,P17844,Q16630,Q14839,P20700,Q05519,Q07666,P09234,P62316,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9Y265,O75400 491 2.80e-08 639 45 15 0.333 0.023 HPA:040040_12 hpa 1 soft tissue 2; peripheral nerve[Supportive,Medium] 1 P12270,P09012,P52272,O94906,Q14974,Q16630,Q13123,P20700,P49756,Q07666,P09234,P62316,Q08211,O75475,Q9UHX1 491 3.25e-08 3521 45 33 0.733 0.009 HPA:023010_02 hpa 1 lymph node; germinal center cells[Uncertain,Medium] 1 P12270,P09012,P52272,Q13243,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,P52701,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,Q08945,P49792,O15042,O75475,Q9NYV4,O95400,Q9BUQ8,Q9Y265,Q9P258,Q9UHX1,O75400,O00571 491 3.77e-08 111 45 8 0.178 0.072 GO:0006405 BP 1 RNA export from nucleus 1 P12270,Q13243,Q05519,Q07666,P62826,Q8IYB3,Q09161,P49792 491 3.82e-08 555 45 14 0.311 0.025 HPA:039020_12 hpa 1 soft tissue 1; chondrocytes[Supportive,Medium] 1 P12270,O94906,Q14974,P17844,Q16630,Q13123,P20700,P52701,Q07666,P09234,P62316,Q08211,Q09161,P49792 491 4.02e-08 995 45 18 0.400 0.018 HPA:042010_13 hpa 1 stomach 1; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q92841,O94906,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P09234,P62316,Q8IYB3,Q08211,Q9NYV4,O75400 491 4.03e-08 1121 45 19 0.422 0.017 HPA:010010_13 hpa 1 duodenum; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,Q16630,Q14839,Q13123,P20700,Q05519,P49756,Q07666,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O75400 491 4.05e-08 112 45 8 0.178 0.071 GO:0004386 MF 1 helicase activity 1 Q92841,P17844,O43143,Q14839,Q08211,Q9BUQ8,Q9Y265,O00571 491 4.24e-08 3415 45 32 0.711 0.009 GO:0032991 CC 1 macromolecular complex 1 P12270,O95983,P09012,P52272,P55769,O94906,Q14974,P17844,O43143,Q16630,Q14839,P52701,P49756,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,P49792,O75475,Q9NYV4,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373,O00571 491 4.36e-08 6671 45 43 0.956 0.006 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O15042,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,Q9UHX1,P62304,O75400,O95373,O00571 491 4.51e-08 3344 45 32 0.711 0.010 HPA:028010_10 hpa 1 parathyroid gland; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 4.53e-08 1129 45 19 0.422 0.017 HPA:016010_13 hpa 1 gallbladder; glandular cells[Supportive,High] 1 P12270,O95983,Q9BXP5,P52272,O94906,P17844,Q16630,Q14839,Q13123,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,O75475,Q9NYV4 491 4.92e-08 3355 45 32 0.711 0.010 HPA:024010_10 hpa 1 nasopharynx; respiratory epithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 5.45e-08 3368 45 32 0.711 0.010 HPA:046030_10 hpa 1 tonsil; squamous epithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 5.72e-08 4990 45 38 0.844 0.008 GO:0044260 BP 1 cellular macromolecule metabolic process 1 P12270,O95983,P09012,Q9BXP5,P52272,P55769,Q92841,Q13243,O94906,Q14974,P17844,O43143,Q16630,Q14839,O14776,P52701,Q05519,P49756,Q07666,P09234,P62316,P62826,Q8IYB3,Q6P1J9,Q08211,Q09161,P62306,Q08945,P49792,O75475,Q9NYV4,Q53GS9,O95400,Q9BUQ8,Q9Y265,P62304,O75400,O00571 491 6.28e-08 3386 45 32 0.711 0.009 HPA:020020_10 hpa 1 lateral ventricle; neuronal cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.48e-08 3390 45 32 0.711 0.009 HPA:004010_10 hpa 1 breast; adipocytes[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 6.70e-08 1291 45 20 0.444 0.015 HPA:026010_11 hpa 1 ovary; follicle cells[Supportive,Low] 1 P12270,P52272,Q92841,O94906,P17844,Q14839,P20700,P52701,P49756,Q07666,Q2TAY7,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,O95400,Q9Y265,Q9UHX1 491 7.07e-08 1583 45 22 0.489 0.014 HPA:040030_11 hpa 1 soft tissue 2; fibroblasts[Supportive,Low] 1 P12270,P09012,P52272,O94906,Q14974,P17844,Q16630,Q13123,P20700,O14776,Q05519,Q07666,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,Q9UHX1 491 7.28e-08 3405 45 32 0.711 0.009 HPA:033010_10 hpa 1 seminal vesicle; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.30e-08 489 45 13 0.289 0.027 HPA:006030_13 hpa 1 cerebellum; cells in molecular layer[Supportive,High] 1 P09012,P52272,Q16630,Q14839,P20700,Q05519,Q07666,P09234,P62316,Q8IYB3,Q08211,O75475,Q9NYV4 491 7.40e-08 3407 45 32 0.711 0.009 HPA:046010_10 hpa 1 tonsil; germinal center cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.43e-08 22 45 5 0.111 0.227 GO:0046540 CC 1 U4/U6 x U5 tri-snRNP complex 1 P55769,O94906,P62316,O95400,P62304 491 7.45e-08 913 45 17 0.378 0.019 HPA:039020_11 hpa 1 soft tissue 1; chondrocytes[Supportive,Low] 1 P12270,P09012,O94906,Q14974,P17844,Q16630,Q13123,P20700,P52701,Q07666,P09234,P62316,Q08211,Q09161,P49792,Q9Y265,Q9UHX1 491 7.69e-08 3412 45 32 0.711 0.009 HPA:035040_10 hpa 1 skin 1; melanocytes[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.75e-08 3413 45 32 0.711 0.009 HPA:004030_10 hpa 1 breast; myoepithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.87e-08 3415 45 32 0.711 0.009 HPA:035030_10 hpa 1 skin 1; keratinocytes[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.93e-08 3416 45 32 0.711 0.009 HPA:004020_10 hpa 1 breast; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.93e-08 3416 45 32 0.711 0.009 HPA:003010_10 hpa 1 bone marrow; hematopoietic cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 7.93e-08 3416 45 32 0.711 0.009 HPA:035010_10 hpa 1 skin 1; Langerhans[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.05e-08 3418 45 32 0.711 0.009 HPA:025010_10 hpa 1 oral mucosa; squamous epithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.18e-08 3420 45 32 0.711 0.009 HPA:041020_10 hpa 1 spleen; cells in white pulp[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.24e-08 3421 45 32 0.711 0.009 HPA:009020_10 hpa 1 colon; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.31e-08 3422 45 32 0.711 0.009 HPA:016010_10 hpa 1 gallbladder; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.31e-08 3422 45 32 0.711 0.009 HPA:021010_10 hpa 1 liver; bile duct cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.37e-08 3423 45 32 0.711 0.009 HPA:048010_10 hpa 1 vagina; squamous epithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.37e-08 3423 45 32 0.711 0.009 HPA:013010_10 hpa 1 epididymis; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.44e-08 3424 45 32 0.711 0.009 HPA:023020_10 hpa 1 lymph node; non-germinal center cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.48e-08 921 45 17 0.378 0.018 HPA:001010_13 hpa 1 adrenal gland; glandular cells[Supportive,High] 1 P12270,Q9BXP5,P52272,P17844,Q16630,Q14839,Q13123,P52701,Q05519,Q07666,P09234,P62316,Q6P1J9,Q08211,Q09161,P49792,Q9NYV4 491 8.57e-08 3426 45 32 0.711 0.009 HPA:020010_10 hpa 1 lateral ventricle; glial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.77e-08 3429 45 32 0.711 0.009 HPA:042010_10 hpa 1 stomach 1; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.77e-08 3429 45 32 0.711 0.009 HPA:006020_10 hpa 1 cerebellum; cells in granular layer[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.77e-08 3429 45 32 0.711 0.009 HPA:012010_10 hpa 1 endometrium 2; cells in endometrial stroma[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.83e-08 3430 45 32 0.711 0.009 HPA:012020_10 hpa 1 endometrium 2; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:006030_10 hpa 1 cerebellum; cells in molecular layer[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:007040_10 hpa 1 cerebral cortex; neuropil[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:043010_10 hpa 1 stomach 2; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:031010_10 hpa 1 rectum; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:019010_10 hpa 1 kidney; cells in glomeruli[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:046020_10 hpa 1 tonsil; non-germinal center cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.90e-08 3431 45 32 0.711 0.009 HPA:002010_10 hpa 1 appendix; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:034010_10 hpa 1 skeletal muscle; myocytes[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:047010_10 hpa 1 urinary bladder; urothelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:018010_10 hpa 1 hippocampus; glial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:026020_10 hpa 1 ovary; ovarian stroma cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:014010_10 hpa 1 esophagus; squamous epithelial cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:001010_10 hpa 1 adrenal gland; glandular cells[Supportive,Not detected] 1 P12270,O95983,P09012,Q9BXP5,P52272,Q92841,O94906,Q14974,P17844,Q16630,Q14839,Q13123,P20700,O14776,P52701,Q05519,P49756,Q07666,Q2TAY7,P09234,P62316,Q8IYB3,Q6P1J9,Q08211,Q09161,P49792,O75475,Q9NYV4,O95400,Q9Y265,Q9UHX1,O75400 491 8.97e-08 3432 45 32 0.711 0.009 HPA:011010_10 hpa 1 endometrium 1; cells in endometrial stroma[Supportive,Not detected] 1 P12270,O95983,P09012,