hu.MAP: Complex View
Human Protein Complex Map
Search for a protein
Complex: 1786
Proteins| Genename | Complexes | Protein Name | Links |
|---|---|---|---|
| CENPJ | 1786 2611 3349 | Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1) | UniProt NCBI |
| FLAD1 | 1786 2611 3349 | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | UniProt NCBI |
| TACC3 | 1786 2097 | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | UniProt NCBI |
| PLEKHO2 | 1786 2611 3349 | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| OMIM:613676 | 0.00336 | 0.25 | CENPJ | SECKEL SYNDROME 4; SCKL4 |
| OMIM:608393 | 0.00336 | 0.25 | CENPJ | MICROCEPHALY 6, PRIMARY, AUTOSOMAL RECESSIVE; MCPH6 |
| MI:hsa-miR-183* | 0.00444 | 0.5 | FLAD1 CENPJ | MI:hsa-miR-183* |
| MI:mmu-miR-705 | 0.00753 | 0.5 | FLAD1 PLEKHO2 | MI:mmu-miR-705 |
| MI:hsa-miR-620 | 0.00793 | 0.5 | CENPJ TACC3 | MI:hsa-miR-620 |
| GO:0070507 | 0.00899 | 0.5 | CENPJ TACC3 | regulation of microtubule cytoskeleton organization |
| GO:0003919 | 0.01 | 0.25 | FLAD1 | FMN adenylyltransferase activity |
| MI:mmu-miR-878-5p | 0.0103 | 0.5 | CENPJ TACC3 | MI:mmu-miR-878-5p |
| MI:hsa-miR-128a | 0.0112 | 0.5 | FLAD1 CENPJ | MI:hsa-miR-128a |
| HP:0010455 | 0.0119 | 0.25 | CENPJ | Steep acetabular roof |
| HP:0007048 | 0.0119 | 0.25 | CENPJ | Large basal ganglia |
| HP:0006442 | 0.0119 | 0.25 | CENPJ | Hypoplasia of proximal fibula |
| HP:0030148 | 0.0133 | 0.25 | CENPJ | Heart murmur |
| HP:0006434 | 0.0133 | 0.25 | CENPJ | Hypoplasia of proximal radius |
| GO:0032886 | 0.0138 | 0.5 | CENPJ TACC3 | regulation of microtubule-based process |
| HP:0011342 | 0.0148 | 0.25 | CENPJ | Mild global developmental delay |
| HPA:040020 | 0.0172 | 0.75 | FLAD1 PLEKHO2 TACC3 | soft tissue 2; chondrocytes |
| TF:M04045_1 | 0.0177 | 0.25 | CENPJ | Factor: MYBL1; motif: GNCNGTTANWACSGTTR; match class: 1 |
| HP:0007429 | 0.0178 | 0.25 | CENPJ | Few cafe-au-lait spots |
| HP:0003683 | 0.0192 | 0.25 | CENPJ | Large beaked nose |
| HP:0010583 | 0.0207 | 0.25 | CENPJ | Ivory epiphyses |
| HP:0011019 | 0.0207 | 0.25 | CENPJ | Abnormality of chromosome condensation |
| HP:0002472 | 0.0207 | 0.25 | CENPJ | Small cerebral cortex |
| HP:0003451 | 0.0207 | 0.25 | CENPJ | Increased rate of premature chromosome condensation |
| HP:0000237 | 0.0207 | 0.25 | CENPJ | Small anterior fontanelle |
| HP:0000171 | 0.0222 | 0.25 | CENPJ | Microglossia |
| OMIM:210600 | 0.0234 | 0.25 | CENPJ | Seckel Syndrome |
| HP:0010636 | 0.0251 | 0.25 | CENPJ | Schizencephaly |
| HP:0006143 | 0.0251 | 0.25 | CENPJ | Abnormal finger flexion creases |
| TF:M02272_0 | 0.0261 | 0.5 | FLAD1 TACC3 | Factor: RXR:RAR; motif: RGKTCANNNRGAGGTCA; match class: 0 |
| TF:M07308_1 | 0.0276 | 0.5 | FLAD1 CENPJ | Factor: Sox2; motif: NNNANAACAAWGRNN; match class: 1 |
| TF:M05965_0 | 0.0332 | 0.25 | FLAD1 | Factor: ZNF175; motif: NTRTYAAWGAGA; match class: 0 |
| HP:0002176 | 0.0338 | 0.25 | CENPJ | Spinal cord compression |
| HP:0100710 | 0.0338 | 0.25 | CENPJ | Impulsivity |
| HP:0001592 | 0.0338 | 0.25 | CENPJ | Selective tooth agenesis |
| HPA:040020_10 | 0.0383 | 0.5 | FLAD1 TACC3 | soft tissue 2; chondrocytes[Supportive,Not detected] |
| GO:0008275 | 0.04 | 0.25 | CENPJ | gamma-tubulin small complex |
| GO:0006771 | 0.04 | 0.25 | FLAD1 | riboflavin metabolic process |
| GO:0061511 | 0.04 | 0.25 | CENPJ | centriole elongation |
| TF:M01783_0 | 0.0422 | 0.75 | FLAD1 PLEKHO2 TACC3 | Factor: SP2; motif: GGGCGGGAC; match class: 0 |
| HP:0001335 | 0.0439 | 0.25 | CENPJ | Bimanual synkinesia |
| TF:M06783_0 | 0.0442 | 0.25 | TACC3 | Factor: znf443; motif: KGKTTCTGGCGG; match class: 0 |
| HP:0003038 | 0.0454 | 0.25 | CENPJ | Fibular hypoplasia |
| HP:0000878 | 0.0468 | 0.25 | CENPJ | 11 pairs of ribs |
| HP:0003220 | 0.0468 | 0.25 | CENPJ | Abnormality of chromosome stability |
| HP:0009906 | 0.0468 | 0.25 | CENPJ | Aplasia/Hypoplasia of the earlobes |
| HP:0010230 | 0.0483 | 0.25 | CENPJ | Cone-shaped epiphyses of the phalanges of the hand |
| HP:0006492 | 0.0497 | 0.25 | CENPJ | Aplasia/Hypoplasia of the fibula |
| TF:M03868_1 | 0.05 | 1.0 | FLAD1 PLEKHO2 CENPJ TACC3 | Factor: CP2; motif: NTGNCTGGNN; match class: 1 |
| KEGG:00740 | 0.05 | 0.25 | FLAD1 | Riboflavin metabolism |
| OMIM:251200 | 0.05 | 0.25 | CENPJ | Primary Microcephaly |
| REAC:196843 | 0.05 | 0.25 | FLAD1 | Vitamin B2 (riboflavin) metabolism |
| CORUM:5373 | 0.05 | 0.25 | TACC3 | Chromatin remodeling complex (TACC2, TACC3, PCAF) |
| GO:0042726 | 0.05 | 0.25 | FLAD1 | flavin-containing compound metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Evidence |
|---|---|---|---|
| CENPJ | PLEKHO2 | 0.958175 | bioplex (PLEKHO2) bioplex_prey |
| TACC3 | PLEKHO2 | 0.901215 | bioplex (PLEKHO2) bioplex_prey |
| FLAD1 | PLEKHO2 | 0.843721 | bioplex (PLEKHO2) bioplex_prey |
| CENPJ | FLAD1 | 0.140692 | bioplex_prey |
| CENPJ | TACC3 | 0.123789 | bioplex_prey |
| FLAD1 | TACC3 | 0.100649 | bioplex_prey |
Images
Click to enlarge
