hu.MAP: Complex View

Human Protein Complex Map

Complex: 2097

Genename	Complexes	Protein Name	Links
ARX	2097	Homeobox protein ARX (Aristaless-related homeobox)	UniProt NCBI
TACC3	1786 2097	Transforming acidic coiled-coil-containing protein 3 (ERIC-1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
OMIM:300215	0.00133	0.5	ARX	LISSENCEPHALY, X-LINKED, 2; LISX2;;LISSENCEPHALY, X-LINKED, WITH AMBIGUOUS GENITALIA; XLAG;;XLISGHYDRANENCEPHALY AND ABNORMAL GENITALIA, INCLUDED
OMIM:300004	0.00133	0.5	ARX	CORPUS CALLOSUM, AGENESIS OF, WITH ABNORMAL GENITALIA;;ACC WITH ABNORMAL GENITALIA;;PROUD SYNDROME
OMIM:309510	0.00133	0.5	ARX	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME; PRTS;;PARTINGTON SYNDROME;;MENTAL RETARDATION, X-LINKED, SYNDROMIC 1; MRXS1;;MENTAL RETARDATION, X-LINKED, WITH DYSTONIC MOVEMENTS, ATAXIA, ANDSEIZURES;;MENTAL RETARDATION, X-LINKED 36; MRX36
OMIM:300419	0.00133	0.5	ARX	MENTAL RETARDATION, X-LINKED, WITH OR WITHOUT SEIZURES, ARX-RELATED;MRXARX;;MENTAL RETARDATION, X-LINKED 29; MRX29;;MENTAL RETARDATION, X-LINKED 32; MRX32;;MENTAL RETARDATION, X-LINKED 33; MRX33;;MENTAL RETARDATION, X-LINKED 38; MRX38;;MENTAL RETARDATION, X-LINKED 43; MRX43;;MENTAL RETARDATION, X-LINKED 54; MRX54;;MENTAL RETARDATION, X-LINKED 76; MRX76;;MENTAL RETARDATION, X-LINKED 87; MRX87
HP:0011341	0.00298	0.5	ARX	Long upper lip
HP:0009921	0.00446	0.5	ARX	Duane anomaly
HP:0000187	0.00817	0.5	ARX	Broad alveolar ridges
HP:0002451	0.00891	0.5	ARX	Limb dystonia
HP:0002476	0.00965	0.5	ARX	Primitive reflex
HP:0001845	0.00965	0.5	ARX	Overlapping toe
HP:0001795	0.0104	0.5	ARX	Hyperconvex nail
OMIM:607432	0.0106	0.5	ARX	Lissencephaly
HP:0006477	0.0119	0.5	ARX	Abnormality of the alveolar ridges
HP:0010851	0.0141	0.5	ARX	EEG with burst suppression
TF:M02107_0	0.0148	1.0	ARX TACC3	Factor: NF-YC; motif: NRGCCAATYAGMGC; match class: 0
HP:0010818	0.0156	0.5	ARX	Generalized tonic seizures
HP:0007105	0.017	0.5	ARX	Infantile encephalopathy
HP:0001738	0.0178	0.5	ARX	Exocrine pancreatic insufficiency
HP:0011398	0.0185	0.5	ARX	Central hypotonia
HP:0001151	0.0193	0.5	ARX	Impaired horizontal smooth pursuit
HP:0009909	0.0193	0.5	ARX	Uplifted earlobe
HP:0012092	0.0222	0.5	ARX	Abnormality of exocrine pancreas physiology
HP:0012469	0.0222	0.5	ARX	Infantile spasms
HP:0002445	0.0237	0.5	ARX	Tetraplegia
HP:0006808	0.0244	0.5	ARX	Cerebral hypomyelination
HP:0011097	0.0244	0.5	ARX	Epileptic spasms
HP:0000053	0.0252	0.5	ARX	Macroorchidism
HP:0001090	0.0259	0.5	ARX	Large eyes
HP:0003623	0.0259	0.5	ARX	Neonatal onset
GO:0060236	0.027	0.5	TACC3	regulation of mitotic spindle organization
HP:0002883	0.0296	0.5	ARX	Hyperventilation
HP:0000294	0.0296	0.5	ARX	Low anterior hairline
HP:0002375	0.0296	0.5	ARX	Hypokinesia
HP:0001833	0.0296	0.5	ARX	Long foot
GO:0090224	0.0297	0.5	TACC3	regulation of spindle organization
HP:0000966	0.031	0.5	ARX	Hypohidrosis
HP:0002373	0.0325	0.5	ARX	Febrile seizures
HP:0000805	0.0325	0.5	ARX	Enuresis
HP:0000260	0.0325	0.5	ARX	Wide anterior fontanel
HP:0002374	0.0332	0.5	ARX	Diminished movement
HP:0030182	0.0354	0.5	ARX	Tetraplegia/tetraparesis
HP:0000253	0.0361	0.5	ARX	Progressive microcephaly
HP:0002133	0.0369	0.5	ARX	Status epilepticus
HP:0004373	0.0376	0.5	ARX	Focal dystonia
HP:0200134	0.0376	0.5	ARX	Epileptic encephalopathy
HP:0000817	0.0383	0.5	ARX	Poor eye contact
HP:0000336	0.0391	0.5	ARX	Prominent supraorbital ridges
HP:0011304	0.0398	0.5	ARX	Broad thumb
HP:0002307	0.0405	0.5	ARX	Drooling
GO:0021987	0.0406	0.5	TACC3	cerebral cortex development
MI:hsa-miR-32*	0.0421	0.5	TACC3	MI:hsa-miR-32*
HP:0002880	0.0427	0.5	ARX	Respiratory difficulties
TF:M05574_0	0.0428	0.5	ARX	Factor: ZFP92; motif: NGGGAMGGCGTC; match class: 0
HP:0003429	0.0434	0.5	ARX	CNS hypomyelination
HP:0003781	0.0434	0.5	ARX	Excessive salivation
HP:0001339	0.0434	0.5	ARX	Lissencephaly
HP:0002521	0.0434	0.5	ARX	Hypsarrhythmia
MI:hsa-miR-377*	0.0435	0.5	ARX	MI:hsa-miR-377*
HP:0000735	0.0456	0.5	ARX	Impaired social interactions
HP:0002194	0.0456	0.5	ARX	Delayed gross motor development
HP:0009879	0.0471	0.5	ARX	Cortical gyral simplification
HP:0000649	0.0471	0.5	ARX	Abnormality of visual evoked potentials
HP:0012433	0.0471	0.5	ARX	Abnormal social behavior
HP:0001182	0.0471	0.5	ARX	Tapered finger
TF:M06783_0	0.0475	0.5	TACC3	Factor: znf443; motif: KGKTTCTGGCGG; match class: 0
HP:0001266	0.0478	0.5	ARX	Choreoathetosis
HP:0009768	0.0478	0.5	ARX	Broad phalanges of the hand
HP:0000713	0.0485	0.5	ARX	Agitation
HP:0011198	0.0493	0.5	ARX	EEG with generalized epileptiform discharges
HP:0000110	0.0493	0.5	ARX	Renal dysplasia
TF:M06139_0	0.0499	0.5	ARX	Factor: ZNF324; motif: NCTGGMATGGGM; match class: 0
HP:0011003	0.05	0.5	ARX	Severe Myopia
HP:0011182	0.05	0.5	ARX	Epileptiform EEG discharges
HP:0001500	0.05	0.5	ARX	Broad finger
HP:0007359	0.05	0.5	ARX	Focal seizures
GO:0010965	0.05	0.5	TACC3	regulation of mitotic sister chromatid separation
GO:0007091	0.05	0.5	TACC3	metaphase/anaphase transition of mitotic cell cycle
CORUM:5373	0.05	0.5	TACC3	Chromatin remodeling complex (TACC2, TACC3, PCAF)
OMIM:308350	0.05	0.5	ARX	Early Infantile Epileptic Encephalopathy
TF:M00205_1	0.05	1.0	ARX TACC3	Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1
GO:0021543	0.05	0.5	TACC3	pallium development

Edges

Protein 1	Protein 2	Score	Evidence
TACC3	ARX	0.894532	hein (ARX) hein_prey

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hu.MAP: Complex View

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Complex: 2097