hu.MAP: Complex View
Human Protein Complex Map
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Complex: 3349
Proteins| Genename | Complexes | Protein Name | Links |
|---|---|---|---|
| CENPJ | 1786 2611 3349 | Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1) | UniProt NCBI |
| MAP3K6 | 2611 3349 3724 | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | UniProt NCBI |
| FLAD1 | 1786 2611 3349 | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | UniProt NCBI |
| PLEKHO2 | 1786 2611 3349 | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| OMIM:613676 | 0.00336 | 0.25 | CENPJ | SECKEL SYNDROME 4; SCKL4 |
| OMIM:608393 | 0.00336 | 0.25 | CENPJ | MICROCEPHALY 6, PRIMARY, AUTOSOMAL RECESSIVE; MCPH6 |
| MI:hsa-miR-183* | 0.00444 | 0.5 | FLAD1 CENPJ | MI:hsa-miR-183* |
| MI:hsa-miR-511 | 0.00662 | 0.5 | MAP3K6 FLAD1 | MI:hsa-miR-511 |
| MI:mmu-miR-705 | 0.00753 | 0.5 | FLAD1 PLEKHO2 | MI:mmu-miR-705 |
| MI:hsa-miR-450b-3p | 0.00838 | 0.5 | MAP3K6 CENPJ | MI:hsa-miR-450b-3p |
| MI:hsa-miR-133a | 0.0101 | 0.5 | MAP3K6 FLAD1 | MI:hsa-miR-133a |
| MI:hsa-miR-133b | 0.0101 | 0.5 | MAP3K6 FLAD1 | MI:hsa-miR-133b |
| MI:hsa-miR-128a | 0.0112 | 0.5 | FLAD1 CENPJ | MI:hsa-miR-128a |
| GO:0003919 | 0.0125 | 0.25 | FLAD1 | FMN adenylyltransferase activity |
| HP:0002582 | 0.0167 | 0.25 | MAP3K6 | Chronic atrophic gastritis |
| HP:0005231 | 0.0167 | 0.25 | MAP3K6 | Chronic gastritis |
| OMIM:210600 | 0.0234 | 0.25 | CENPJ | Seckel Syndrome |
| HP:0010455 | 0.0334 | 0.25 | CENPJ | Steep acetabular roof |
| HP:0007048 | 0.0334 | 0.25 | CENPJ | Large basal ganglia |
| HP:0006442 | 0.0334 | 0.25 | CENPJ | Hypoplasia of proximal fibula |
| HP:0030148 | 0.0376 | 0.25 | CENPJ | Heart murmur |
| HP:0006434 | 0.0376 | 0.25 | CENPJ | Hypoplasia of proximal radius |
| HP:0011342 | 0.0417 | 0.25 | CENPJ | Mild global developmental delay |
| HP:0005263 | 0.0459 | 0.25 | MAP3K6 | Gastritis |
| TF:M04475_1 | 0.05 | 0.25 | MAP3K6 | Factor: NR2F6; motif: NRGGTCAAAGGTCA; match class: 1 |
| GO:0008275 | 0.05 | 0.25 | CENPJ | gamma-tubulin small complex |
| TF:M07080_1 | 0.05 | 0.25 | MAP3K6 | Factor: C/EBPbeta; motif: KATTGCAYMAY; match class: 1 |
| GO:0061511 | 0.05 | 0.25 | CENPJ | centriole elongation |
| GO:0006771 | 0.05 | 0.25 | FLAD1 | riboflavin metabolic process |
| HP:0007429 | 0.05 | 0.25 | CENPJ | Few cafe-au-lait spots |
| HP:0012126 | 0.05 | 0.25 | MAP3K6 | Stomach cancer |
| KEGG:00740 | 0.05 | 0.25 | FLAD1 | Riboflavin metabolism |
| OMIM:251200 | 0.05 | 0.25 | CENPJ | Primary Microcephaly |
| REAC:196843 | 0.05 | 0.25 | FLAD1 | Vitamin B2 (riboflavin) metabolism |
Edges
| Protein 1 | Protein 2 | Score | Evidence |
|---|---|---|---|
| CENPJ | PLEKHO2 | 0.958175 | bioplex (PLEKHO2) bioplex_prey |
| FLAD1 | PLEKHO2 | 0.843721 | bioplex (PLEKHO2) bioplex_prey |
| PLEKHO2 | MAP3K6 | 0.743196 | bioplex (PLEKHO2) bioplex_prey |
| CENPJ | MAP3K6 | 0.151455 | bioplex_prey |
| CENPJ | FLAD1 | 0.140692 | bioplex_prey |
| FLAD1 | MAP3K6 | 0.123797 | bioplex_prey |
Images
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