hu.MAP: Complex View

Human Protein Complex Map

Complex: 3724

Genename	Complexes	Protein Name	Links
FAM160B1	3724 4130	Protein FAM160B1	UniProt NCBI
MAP3K6	2611 3349 3724	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)	UniProt NCBI
TNFSF13B	2401 3724 4130	Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]	UniProt NCBI
MAP3K5	2401 3724 4130	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)	UniProt NCBI
PDSS1	1632 3724	Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1)	UniProt NCBI
MAP3K15	2401 3724 4130	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)	UniProt NCBI
FAM118A	2401 3724	Protein FAM118A	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0004709	2.23e-07	0.429	MAP3K6 MAP3K15 MAP3K5	MAP kinase kinase kinase activity
GO:0004702	2.64e-05	0.429	MAP3K6 MAP3K15 MAP3K5	signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0005057	8.56e-05	0.429	MAP3K6 MAP3K15 MAP3K5	signal transducer activity, downstream of receptor
GO:0000186	0.000325	0.286	MAP3K15 MAP3K5	activation of MAPKK activity
GO:0007257	0.000356	0.286	MAP3K6 MAP3K5	activation of JUN kinase activity
GO:0032147	0.000359	0.429	MAP3K6 MAP3K15 MAP3K5	activation of protein kinase activity
GO:0043405	0.000589	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of MAP kinase activity
GO:0043507	0.000934	0.286	MAP3K6 MAP3K5	positive regulation of JUN kinase activity
GO:0043410	0.00122	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of MAPK cascade
GO:0043506	0.00145	0.286	MAP3K6 MAP3K5	regulation of JUN kinase activity
GO:0045860	0.00152	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of protein kinase activity
GO:0033674	0.00192	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of kinase activity
GO:0071900	0.00198	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of protein serine/threonine kinase activity
GO:0046330	0.00298	0.286	MAP3K6 MAP3K5	positive regulation of JNK cascade
GO:0004674	0.00332	0.429	MAP3K6 MAP3K15 MAP3K5	protein serine/threonine kinase activity
HPA:040010_02	0.00367	0.714	MAP3K6 PDSS1 MAP3K15 FAM118A TNFSF13B	soft tissue 2; adipocytes[Uncertain,Medium]
GO:0032874	0.00406	0.286	MAP3K6 MAP3K5	positive regulation of stress-activated MAPK cascade
GO:0043408	0.00411	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of MAPK cascade
GO:0070304	0.00416	0.286	MAP3K6 MAP3K5	positive regulation of stress-activated protein kinase signaling cascade
MI:rno-miR-333	0.00434	0.571	MAP3K6 PDSS1 FAM160B1 MAP3K15	MI:rno-miR-333
GO:0000187	0.0046	0.286	MAP3K6 MAP3K5	activation of MAPK activity
GO:0051347	0.00544	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of transferase activity
GO:0000010	0.00544	0.143	PDSS1	trans-hexaprenyltranstransferase activity
GO:0045859	0.00594	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of protein kinase activity
GO:0046328	0.00616	0.286	MAP3K6 MAP3K5	regulation of JNK cascade
OMIM:614651	0.00719	0.143	PDSS1	COENZYME Q10 DEFICIENCY, PRIMARY, 2; COQ10D2
GO:0043549	0.00767	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of kinase activity
GO:0000287	0.00853	0.286	MAP3K6 MAP3K5	magnesium ion binding
GO:0001934	0.00872	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of protein phosphorylation
GO:0043406	0.00914	0.286	MAP3K6 MAP3K5	positive regulation of MAP kinase activity
GO:0004672	0.00945	0.429	MAP3K6 MAP3K15 MAP3K5	protein kinase activity
GO:0007254	0.00946	0.286	MAP3K6 MAP3K5	JNK cascade
GO:0032872	0.00946	0.286	MAP3K6 MAP3K5	regulation of stress-activated MAPK cascade
GO:0070302	0.00961	0.286	MAP3K6 MAP3K5	regulation of stress-activated protein kinase signaling cascade
GO:1902533	0.0101	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of intracellular signal transduction
GO:0042327	0.0102	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of phosphorylation
TF:M03880_0	0.0108	0.429	PDSS1 MAP3K5 TNFSF13B	Factor: Myf-5; motif: WGRCAGCTGSWGB; match class: 0
GO:1990604	0.0109	0.143	MAP3K5	IRE1-TRAF2-ASK1 complex
GO:0000165	0.0111	0.429	MAP3K6 MAP3K15 MAP3K5	MAPK cascade
GO:0023014	0.0113	0.429	MAP3K6 MAP3K15 MAP3K5	signal transduction by protein phosphorylation
HPA:039040_03	0.0116	0.286	MAP3K6 FAM118A	soft tissue 1; peripheral nerve[Uncertain,High]
GO:0045937	0.0131	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of phosphate metabolic process
GO:0010562	0.0131	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of phosphorus metabolic process
GO:0051403	0.0156	0.286	MAP3K6 MAP3K5	stress-activated MAPK cascade
GO:0031098	0.0162	0.286	MAP3K6 MAP3K5	stress-activated protein kinase signaling cascade
CORUM:5691	0.0167	0.143	TNFSF13B	TALL1 homo-oligomer complex
GO:0051338	0.0168	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of transferase activity
GO:0016773	0.0169	0.429	MAP3K6 MAP3K15 MAP3K5	phosphotransferase activity, alcohol group as acceptor
GO:0071902	0.0183	0.286	MAP3K6 MAP3K5	positive regulation of protein serine/threonine kinase activity
HPA:012010_02	0.0187	0.571	MAP3K6 MAP3K15 FAM118A TNFSF13B	endometrium 2; cells in endometrial stroma[Uncertain,Medium]
GO:0016301	0.0216	0.429	MAP3K6 MAP3K15 MAP3K5	kinase activity
GO:1901663	0.0217	0.143	PDSS1	quinone biosynthetic process
GO:0006743	0.0217	0.143	PDSS1	ubiquinone metabolic process
GO:0006744	0.0217	0.143	PDSS1	ubiquinone biosynthetic process
HPA:026020_01	0.0221	0.857	MAP3K6 FAM160B1 MAP3K15 MAP3K5 FAM118A TNFSF13B	ovary; ovarian stroma cells[Uncertain,Low]
GO:0031401	0.0236	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of protein modification process
HPA:013010_02	0.0238	1.0	MAP3K6 PDSS1 FAM160B1 MAP3K15 MAP3K5 FAM118A TNFSF13B	epididymis; glandular cells[Uncertain,Medium]
TF:M00264_1	0.0241	0.286	MAP3K15 FAM118A	Factor: Staf; motif: MNTTCCCAKMATKCMWNGCRA; match class: 1
GO:0043085	0.0258	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of catalytic activity
GO:0001932	0.0291	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of protein phosphorylation
HPA:044020_02	0.0295	1.0	MAP3K6 PDSS1 FAM160B1 MAP3K15 MAP3K5 FAM118A TNFSF13B	testis; cells in seminiferous ducts[Uncertain,Medium]
GO:0004871	0.0316	0.429	MAP3K6 MAP3K15 MAP3K5	signal transducer activity
GO:0030890	0.0326	0.143	TNFSF13B	positive regulation of B cell proliferation
GO:0005524	0.0352	0.286	MAP3K6 MAP3K5	ATP binding
GO:0008299	0.0353	0.143	PDSS1	isoprenoid biosynthetic process
GO:0016772	0.0359	0.429	MAP3K6 MAP3K15 MAP3K5	transferase activity, transferring phosphorus-containing groups
GO:0042325	0.0366	0.429	MAP3K6 MAP3K15 MAP3K5	regulation of phosphorylation
GO:0009967	0.037	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of signal transduction
GO:0042181	0.0407	0.143	PDSS1	ketone biosynthetic process
GO:0010647	0.042	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of cell communication
GO:0032559	0.0426	0.286	MAP3K6 MAP3K5	adenyl ribonucleotide binding
GO:0023056	0.0428	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of signaling
HPA:005010_02	0.0448	1.0	MAP3K6 PDSS1 FAM160B1 MAP3K15 MAP3K5 FAM118A TNFSF13B	bronchus; respiratory epithelial cells[Uncertain,Medium]
GO:0030554	0.0459	0.286	MAP3K6 MAP3K5	adenyl nucleotide binding
GO:0032270	0.0471	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of cellular protein metabolic process
KEGG:04672	0.0478	0.143	TNFSF13B	Intestinal immune network for IgA production
GO:0030888	0.0488	0.143	TNFSF13B	regulation of B cell proliferation
TF:M07080_1	0.05	0.143	MAP3K6	Factor: C/EBPbeta; motif: KATTGCAYMAY; match class: 1
CORUM:1297	0.05	0.143	MAP3K5	MKK4-ARRB2-ASK1 complex
KEGG:00900	0.05	0.143	PDSS1	Terpenoid backbone biosynthesis
OMIM:607426	0.05	0.143	PDSS1	Primary Coenzyme Q10 Deficiency
HP:0002582	0.05	0.143	MAP3K6	Chronic atrophic gastritis
TF:M04475_1	0.05	0.143	MAP3K6	Factor: NR2F6; motif: NRGGTCAAAGGTCA; match class: 1
MI:hsa-miR-148b*	0.05	0.429	MAP3K6 FAM160B1 MAP3K15	MI:hsa-miR-148b*
GO:0044093	0.05	0.429	MAP3K6 MAP3K15 MAP3K5	positive regulation of molecular function
HP:0005231	0.05	0.143	MAP3K6	Chronic gastritis
REAC:2142789	0.05	0.143	PDSS1	Ubiquinol biosynthesis

Edges

Protein 1	Protein 2	Score	Evidence
TNFSF13B	MAP3K15	0.980426	bioplex (TNFSF13B) bioplex_prey
TNFSF13B	MAP3K5	0.977277	bioplex (TNFSF13B) bioplex_prey
TNFSF13B	FAM160B1	0.970701	bioplex (TNFSF13B) bioplex_prey
TNFSF13B	FAM118A	0.961271	bioplex (TNFSF13B) bioplex_prey
PDSS1	TNFSF13B	0.81985	bioplex (TNFSF13B) bioplex_prey
TNFSF13B	MAP3K6	0.778175	bioplex (TNFSF13B) bioplex_prey
FAM118A	MAP3K5	0.171414	bioplex_prey
FAM118A	MAP3K15	0.171414	bioplex_prey
MAP3K5	MAP3K15	0.171414	bioplex_prey
PDSS1	MAP3K15	0.151455	bioplex_prey
FAM118A	MAP3K6	0.151455	bioplex_prey
MAP3K15	MAP3K6	0.151455	bioplex_prey
FAM118A	FAM160B1	0.151455	bioplex_prey
MAP3K5	FAM160B1	0.151455	bioplex_prey
MAP3K15	FAM160B1	0.151455	bioplex_prey
MAP3K5	MAP3K6	0.151455	bioplex_prey
PDSS1	MAP3K5	0.151455	bioplex_prey
PDSS1	FAM118A	0.151455	bioplex_prey
MAP3K6	FAM160B1	0.133456	bioplex_prey
PDSS1	MAP3K6	0.133456	bioplex_prey
PDSS1	FAM160B1	0.133456	bioplex_prey

Images

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hu.MAP: Complex View

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Complex: 3724